Unicorn Papers - Top cited papers from PUBMED

No.	Citations	EC_cit	RCR	EC_RCR	Title	Authors	Journal	Year	PMID	Article(?)
1	165917	165917.0	0.0	0.0	Cleavage of structural proteins during the assembly of the head of bacteriophage T4.	U K Laemmli	Nature	1970	5432063	Yes
2	130540	130540.0	0.0	0.0	A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.	M M Bradford	Anal Biochem	1976	942051	Yes
3	193778	48444.5	0.0	0.0	Protein measurement with the Folin phenol reagent.	O H LOWRY, N J ROSEBROUGH, A L FARR, R J RANDALL	J Biol Chem	1951	14907713	Yes
4	87352	43676.0	2435.99	1218.0	Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.	K J Livak, T D Schmittgen	Methods	2001	11846609	Yes
5	40904	40904.0	1517.68	1517.7	A short history of SHELX.	George M Sheldrick	Acta Crystallogr A	2008	18156677	Yes
6	27681	27681.0	1131.79	1131.8	Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.	T Mosmann	J Immunol Methods	1983	6606682	Yes
7	23326	23326.0	0.0	0.0	Detection of specific sequences among DNA fragments separated by gel electrophoresis.	E M Southern	J Mol Biol	1975	1195397	Yes
8	22801	22801.0	543.66	543.7	MicroRNAs: genomics, biogenesis, mechanism, and function.	David P Bartel	Cell	2004	14744438	No
9	45369	22684.5	1806.6	903.3	Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.	P Chomczynski, N Sacchi	Anal Biochem	1987	2440339	Yes
10	22469	22469.0	0.0	0.0	The assessment and analysis of handedness: the Edinburgh inventory.	R C Oldfield	Neuropsychologia	1971	5146491	Yes
11	19884	19884.0	505.95	505.9	A new mathematical model for relative quantification in real-time RT-PCR.	M W Pfaffl	Nucleic Acids Res	2001	11328886	Yes
12	19824	19824.0	515.12	515.1	MUSCLE: multiple sequence alignment with high accuracy and high throughput.	Robert C Edgar	Nucleic Acids Res	2004	15034147	Yes
13	17969	17969.0	0.0	0.0	A rating scale for depression.	M HAMILTON	J Neurol Neurosurg Psychiatry	1960	14399272	Yes
14	49153	16384.3	0.0	0.0	"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician.	M F Folstein, S E Folstein, P R McHugh	J Psychiatr Res	1975	1202204	Yes
15	31916	15958.0	1173.2	586.6	The neighbor-joining method: a new method for reconstructing phylogenetic trees.	N Saitou, M Nei	Mol Biol Evol	1987	3447015	Yes
16	45200	15066.7	0.0	0.0	DNA sequencing with chain-terminating inhibitors.	F Sanger, S Nicklen, A R Coulson	Proc Natl Acad Sci U S A	1977	271968	Yes
17	29378	14689.0	1106.13	553.1	Hallmarks of cancer: the next generation.	Douglas Hanahan, Robert A Weinberg	Cell	2011	21376230	No
18	14511	14511.0	534.35	534.4	CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP.	Joseph Felsenstein	Evolution	1985	28561359	Yes
19	14414	14414.0	610.55	610.5	Density-functional exchange-energy approximation with correct asymptotic behavior.	Becke	Phys Rev A Gen Phys	1988	9900728	Yes
20	14320	14320.0	0.0	0.0	The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.	E S REYNOLDS	J Cell Biol	1963	13986422	Yes
21	13854	13854.0	408.33	408.3	Atherosclerosis--an inflammatory disease.	R Ross	N Engl J Med	1999	9887164	No
22	13793	13793.0	0.0	0.0	Tissue sulfhydryl groups.	G L ELLMAN	Arch Biochem Biophys	1959	13650640	Yes
23	27391	13695.5	1621.81	810.9	Statistical methods for assessing agreement between two methods of clinical measurement.	J M Bland, D G Altman	Lancet	1986	2868172	Yes
24	13367	13367.0	585.92	585.9	A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences.	M Kimura	J Mol Evol	1980	7463489	Yes
25	38324	12774.7	1275.72	425.2	CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.	J D Thompson, D G Higgins, T J Gibson	Nucleic Acids Res	1994	7984417	Yes
26	25518	12759.0	0.0	0.0	The measurement of observer agreement for categorical data.	J R Landis, G G Koch	Biometrics	1977	843571	Yes
27	12443	12443.0	352.79	352.8	MicroRNAs: target recognition and regulatory functions.	David P Bartel	Cell	2009	19167326	No
28	35625	11875.0	0.0	0.0	Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.	H Towbin, T Staehelin, J Gordon	Proc Natl Acad Sci U S A	1979	388439	Yes
29	11687	11687.0	0.0	0.0	High resolution two-dimensional electrophoresis of proteins.	P H O'Farrell	J Biol Chem	1975	236308	Yes
30	11544	11544.0	361.98	362.0	Projector augmented-wave method.	Blöchl	Phys Rev B Condens Matter	1994	9976227	Yes
31	22994	11497.0	0.0	0.0	A rapid method of total lipid extraction and purification.	E G BLIGH, W J DYER	Can J Biochem Physiol	1959	13671378	Yes
32	22704	11352.0	1019.17	509.6	Meta-analysis in clinical trials.	R DerSimonian, N Laird	Control Clin Trials	1986	3802833	Yes
33	21853	10926.5	1089.88	544.9	The hospital anxiety and depression scale.	A S Zigmond, R P Snaith	Acta Psychiatr Scand	1983	6880820	Yes
34	10926	10926.0	564.14	564.1	A power primer.	J Cohen	Psychol Bull	1992	19565683	Yes
35	10627	10627.0	0.0	0.0	DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.	B J DAVIS	Ann N Y Acad Sci	1964	14240539	Yes
36	10309	10309.0	493.48	493.5	Catalase in vitro.	H Aebi	Methods Enzymol	1984	6727660	Yes
37	30116	10038.7	0.0	0.0	A simple method for the isolation and purification of total lipides from animal tissues.	J FOLCH, M LEES, G H SLOANE STANLEY	J Biol Chem	1957	13428781	Yes
38	9993	9993.0	0.0	0.0	A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.	K BURTON	Biochem J	1956	13293190	Yes
39	9978	9978.0	567.24	567.2	RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies.	Alexandros Stamatakis	Bioinformatics	2014	24451623	Yes
40	19827	9913.5	457.86	228.9	Coot: model-building tools for molecular graphics.	Paul Emsley, Kevin Cowtan	Acta Crystallogr D Biol Crystallogr	2004	15572765	Yes
41	29596	9865.3	1003.06	334.4	Generalized Gradient Approximation Made Simple.	Perdew, Burke, Ernzerhof	Phys Rev Lett	1996	10062328	Yes
42	9583	9583.0	414.24	414.2	Structure validation in chemical crystallography.	Anthony L Spek	Acta Crystallogr D Biol Crystallogr	2009	19171970	Yes
43	18942	9471.0	1010.69	505.3	The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection.	J E Ware, C D Sherbourne	Med Care	1992	1593914	Yes
44	47247	9449.4	1572.59	314.5	Basic local alignment search tool.	S F Altschul, W Gish, W Miller, E W Myers, D J Lipman	J Mol Biol	1990	2231712	Yes
45	18863	9431.5	453.64	226.8	[20] Processing of X-ray diffraction data collected in oscillation mode.	Zbyszek Otwinowski, Wladek Minor	Methods Enzymol	1997	27799103	Yes
46	18605	9302.5	526.59	263.3	Fast and accurate short read alignment with Burrows-Wheeler transform.	Heng Li, Richard Durbin	Bioinformatics	2009	19451168	Yes
47	9106	9106.0	0.0	0.0	The genetics of Caenorhabditis elegans.	S Brenner	Genetics	1974	4366476	Yes
48	9069	9069.0	348.07	348.1	Search and clustering orders of magnitude faster than BLAST.	Robert C Edgar	Bioinformatics	2010	20709691	Yes
49	8882	8882.0	270.47	270.5	XDS.	Wolfgang Kabsch	Acta Crystallogr D Biol Crystallogr	2010	20124692	Yes
50	26398	8799.3	1154.46	384.8	Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density.	Lee, Yang, Parr	Phys Rev B Condens Matter	1988	9944570	Yes
51	8477	8477.0	282.48	282.5	The Psychophysics Toolbox.	D H Brainard	Spat Vis	1997	9176952	Yes
52	8475	8475.0	348.13	348.1	Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS).	J F Kurtzke	Neurology	1983	6685237	Yes
53	8446	8446.0	0.0	0.0	Phosphorus assay in column chromatography.	G R BARTLETT	J Biol Chem	1959	13641241	Yes
54	16475	8237.5	632.87	316.4	Fast gapped-read alignment with Bowtie 2.	Ben Langmead, Steven L Salzberg	Nat Methods	2012	22388286	Yes
55	8011	8011.0	184.67	184.7	Mfold web server for nucleic acid folding and hybridization prediction.	Michael Zuker	Nucleic Acids Res	2003	12824337	Yes
56	7913	7913.0	173.17	173.2	Linear models and empirical bayes methods for assessing differential expression in microarray experiments.	Gordon K Smyth	Stat Appl Genet Mol Biol	2004	16646809	Yes
57	7906	7906.0	228.31	228.3	RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models.	Alexandros Stamatakis	Bioinformatics	2006	16928733	Yes
58	7886	7886.0	366.53	366.5	A new method for measuring daytime sleepiness: the Epworth sleepiness scale.	M W Johns	Sleep	1991	1798888	Yes
59	15710	7855.0	574.86	287.4	A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.	A P Feinberg, B Vogelstein	Anal Biochem	1983	6312838	Yes
60	15639	7819.5	364.52	182.3	The hallmarks of cancer.	D Hanahan, R A Weinberg	Cell	2000	10647931	No
61	15480	7740.0	496.61	248.3	Quantifying heterogeneity in a meta-analysis.	Julian P T Higgins, Simon G Thompson	Stat Med	2002	12111919	Yes
62	7734	7734.0	265.32	265.3	Studies on transformation of Escherichia coli with plasmids.	D Hanahan	J Mol Biol	1983	6345791	Yes
63	7675	7675.0	590.36	590.4	Crystal structure refinement with SHELXL.	George M Sheldrick	Acta Crystallogr C Struct Chem	2015	25567568	Yes
64	7658	7658.0	0.0	0.0	Self-efficacy: toward a unifying theory of behavioral change.	A Bandura	Psychol Rev	1977	847061	Yes
65	7564	7564.0	255.01	255.0	Evolutionary trees from DNA sequences: a maximum likelihood approach.	J Felsenstein	J Mol Evol	1981	7288891	Yes
66	14898	7449.0	793.12	396.6	The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations.	R M Baron, D A Kenny	J Pers Soc Psychol	1986	3806354	Yes
67	14877	7438.5	451.8	225.9	Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set.	Kresse, Furthmüller	Phys Rev B Condens Matter	1996	9984901	Yes
68	7361	7361.0	252.91	252.9	Vitamin D deficiency.	Michael F Holick	N Engl J Med	2007	17634462	No
69	14681	7340.5	496.25	248.1	A simple method for displaying the hydropathic character of a protein.	J Kyte, R F Doolittle	J Mol Biol	1982	7108955	Yes
70	7227	7227.0	259.54	259.5	The pathogenesis of atherosclerosis: a perspective for the 1990s.	R Ross	Nature	1993	8479518	No
71	7135	7135.0	161.86	161.9	The functions of animal microRNAs.	Victor Ambros	Nature	2004	15372042	No
72	21139	7046.3	602.33	200.8	VMD: visual molecular dynamics.	W Humphrey, A Dalke, K Schulten	J Mol Graph	1996	8744570	Yes
73	7043	7043.0	0.0	0.0	On the origin of cancer cells.	O WARBURG	Science	1956	13298683	Yes
74	28126	7031.5	957.76	239.4	Measuring inconsistency in meta-analyses.	Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman	BMJ	2003	12958120	No
75	6989	6989.0	292.14	292.1	Banting lecture 1988. Role of insulin resistance in human disease.	G M Reaven	Diabetes	1988	3056758	No
76	6960	6960.0	0.0	0.0	Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.	A Böyum	Scand J Clin Lab Invest Suppl	1968	4179068	Yes
77	6896	6896.0	0.0	0.0	Improvements in epoxy resin embedding methods.	J H LUFT	J Biophys Biochem Cytol	1961	13764136	Yes
78	6877	6877.0	218.2	218.2	Semiempirical GGA-type density functional constructed with a long-range dispersion correction.	Stefan Grimme	J Comput Chem	2006	16955487	Yes
79	13673	6836.5	329.15	164.6	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.	Kazutoshi Takahashi, Shinya Yamanaka	Cell	2006	16904174	Yes
80	6721	6721.0	219.27	219.3	Integrins: versatility, modulation, and signaling in cell adhesion.	R O Hynes	Cell	1992	1555235	No
81	19987	6662.3	582.26	194.1	Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.	Da Wei Huang, Brad T Sherman, Richard A Lempicki	Nat Protoc	2009	19131956	Yes
82	6571	6571.0	367.2	367.2	Psychophysical bases of perceived exertion.	G A Borg	Med Sci Sports Exerc	1982	7154893	Yes
83	13120	6560.0	300.72	150.4	Processing of X-ray diffraction data collected in oscillation mode.	Z Otwinowski, W Minor	Methods Enzymol	1997	27754618	Yes
84	6552	6552.0	0.0	0.0	COPPER ENZYMES IN ISOLATED CHLOROPLASTS. POLYPHENOLOXIDASE IN BETA VULGARIS.	D I Arnon	Plant Physiol	1949	16654194	Yes
85	6534	6534.0	195.57	195.6	Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.	M C Hochberg	Arthritis Rheum	1997	9324032	Yes
86	13060	6530.0	355.58	177.8	MrBayes 3: Bayesian phylogenetic inference under mixed models.	Fredrik Ronquist, John P Huelsenbeck	Bioinformatics	2003	12912839	Yes
87	26011	6502.8	1153.65	288.4	A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.	M E Charlson, P Pompei, K L Ales, C R MacKenzie	J Chronic Dis	1987	3558716	Yes
88	12894	6447.0	0.0	0.0	The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.	K Weber, M Osborn	J Biol Chem	1969	5806584	Yes
89	6344	6344.0	208.03	208.0	AFNI: software for analysis and visualization of functional magnetic resonance neuroimages.	R W Cox	Comput Biomed Res	1996	8812068	Yes
90	44001	6285.9	1273.7	182.0	Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.	S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J Lipman	Nucleic Acids Res	1997	9254694	No
91	6229	6229.0	185.95	185.9	Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.	F Tajima	Genetics	1989	2513255	Yes
92	6225	6225.0	145.93	145.9	Chromatin modifications and their function.	Tony Kouzarides	Cell	2007	17320507	No
93	6223	6223.0	196.64	196.6	TreeView: an application to display phylogenetic trees on personal computers.	R D Page	Comput Appl Biosci	1996	8902363	Yes
94	12433	6216.5	371.08	185.5	Analyzing real-time PCR data by the comparative C(T) method.	Thomas D Schmittgen, Kenneth J Livak	Nat Protoc	2008	18546601	Yes
95	6197	6197.0	166.06	166.1	PAML 4: phylogenetic analysis by maximum likelihood.	Ziheng Yang	Mol Biol Evol	2007	17483113	Yes
96	24595	6148.8	928.35	232.1	Bias in meta-analysis detected by a simple, graphical test.	M Egger, G Davey Smith, M Schneider, C Minder	BMJ	1997	9310563	Yes
97	12267	6133.5	288.34	144.2	Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana.	S J Clough, A F Bent	Plant J	1998	10069079	Yes
98	18273	6091.0	761.36	253.8	NIH Image to ImageJ: 25 years of image analysis.	Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri	Nat Methods	2012	22930834	No
99	6020	6020.0	194.88	194.9	Canonical dynamics: Equilibrium phase-space distributions.	Hoover	Phys Rev A Gen Phys	1985	9895674	Yes
100	24049	6012.2	1124.89	281.2	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	PLoS Med	2009	19621072	No
101	6010	6010.0	215.54	215.5	The blockade of immune checkpoints in cancer immunotherapy.	Drew M Pardoll	Nat Rev Cancer	2012	22437870	No
102	5951	5951.0	167.72	167.7	Fast robust automated brain extraction.	Stephen M Smith	Hum Brain Mapp	2002	12391568	No
103	5881	5881.0	249.81	249.8	Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses.	Andreas Stang	Eur J Epidemiol	2010	20652370	Yes
104	5840	5840.0	235.34	235.3	Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.	P S Thomas	Proc Natl Acad Sci U S A	1980	6159641	Yes
105	5790	5790.0	221.66	221.7	"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.	W N Burnette	Anal Biochem	1981	6266278	Yes
106	5733	5733.0	0.0	0.0	A simplification of the protein assay method of Lowry et al. which is more generally applicable.	G L Peterson	Anal Biochem	1977	603028	Yes
107	5646	5646.0	233.56	233.6	Density-functional approximation for the correlation energy of the inhomogeneous electron gas.	Perdew	Phys Rev B Condens Matter	1986	9938299	Yes
108	5594	5594.0	227.27	227.3	Ethical guidelines for investigations of experimental pain in conscious animals.	Manfred Zimmermann	Pain	1983	6877845	No
109	5565	5565.0	0.0	0.0	Solvent content of protein crystals.	B W Matthews	J Mol Biol	1968	5700707	Yes
110	5565	5565.0	186.86	186.9	The VideoToolbox software for visual psychophysics: transforming numbers into movies.	D G Pelli	Spat Vis	1997	9176953	Yes
111	5492	5492.0	163.93	163.9	Apoptosis: a review of programmed cell death.	Susan Elmore	Toxicol Pathol	2007	17562483	No
112	5471	5471.0	325.4	325.4	Comparative fit indexes in structural models.	P M Bentler	Psychol Bull	1990	2320703	Yes
113	10882	5441.0	245.12	122.6	KEGG: kyoto encyclopedia of genes and genomes.	M Kanehisa, S Goto	Nucleic Acids Res	2000	10592173	Yes
114	16228	5409.3	763.19	254.4	Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.	Michael I Love, Wolfgang Huber, Simon Anders	Genome Biol	2014	25516281	Yes
115	10811	5405.5	403.42	201.7	Sequencing end-labeled DNA with base-specific chemical cleavages.	A M Maxam, W Gilbert	Methods Enzymol	1980	6246368	Yes
116	5317	5317.0	0.0	0.0	A low-viscosity epoxy resin embedding medium for electron microscopy.	A R Spurr	J Ultrastruct Res	1969	4887011	Yes
117	5295	5295.0	115.96	116.0	Integrins: bidirectional, allosteric signaling machines.	Richard O Hynes	Cell	2002	12297042	No
118	5261	5261.0	0.0	0.0	Tumor angiogenesis: therapeutic implications.	J Folkman	N Engl J Med	1971	4938153	No
119	5247	5247.0	0.0	0.0	Evaluation of survival data and two new rank order statistics arising in its consideration.	N Mantel	Cancer Chemother Rep	1966	5910392	Yes
120	10452	5226.0	514.14	257.1	MAFFT multiple sequence alignment software version 7: improvements in performance and usability.	Kazutaka Katoh, Daron M Standley	Mol Biol Evol	2013	23329690	Yes
121	15628	5209.3	0.0	0.0	Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.	W T Friedewald, R I Levy, D S Fredrickson	Clin Chem	1972	4337382	Yes
122	15495	5165.0	569.67	189.9	A new generation of Ca2+ indicators with greatly improved fluorescence properties.	G Grynkiewicz, M Poenie, R Y Tsien	J Biol Chem	1985	3838314	Yes
123	5149	5149.0	201.45	201.4	The role of protein kinase C in cell surface signal transduction and tumour promotion.	Y Nishizuka	Nature	1984	6232463	No
124	5124	5124.0	128.16	128.2	Inflammation in atherosclerosis.	Peter Libby	Nature	2002	12490960	No
125	5118	5118.0	138.21	138.2	Inflammation, atherosclerosis, and coronary artery disease.	Göran K Hansson	N Engl J Med	2005	15843671	No
126	5097	5097.0	193.93	193.9	The Clinical Dementia Rating (CDR): current version and scoring rules.	J C Morris	Neurology	1993	8232972	Yes
127	15241	5080.3	1348.68	449.6	MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets.	Sudhir Kumar, Glen Stecher, Koichiro Tamura	Mol Biol Evol	2016	27004904	Yes
128	5050	5050.0	153.0	153.0	Angiogenesis in cancer, vascular, rheumatoid and other disease.	J Folkman	Nat Med	1995	7584949	No
129	15091	5030.3	779.46	259.8	Trimmomatic: a flexible trimmer for Illumina sequence data.	Anthony M Bolger, Marc Lohse, Bjoern Usadel	Bioinformatics	2014	24695404	Yes
130	5002	5002.0	99.47	99.5	BLAT--the BLAST-like alignment tool.	W James Kent	Genome Res	2002	11932250	Yes
131	4988	4988.0	135.82	135.8	Biochemistry and molecular cell biology of diabetic complications.	M Brownlee	Nature	2001	11742414	Yes
132	9955	4977.5	0.0	0.0	A rapid alkaline extraction procedure for screening recombinant plasmid DNA.	H C Birnboim, J Doly	Nucleic Acids Res	1979	388356	Yes
133	4961	4961.0	259.14	259.1	Investigation of the freely available easy-to-use software 'EZR' for medical statistics.	Y Kanda	Bone Marrow Transplant	2013	23208313	Yes
134	4958	4958.0	119.37	119.4	p53, the cellular gatekeeper for growth and division.	A J Levine	Cell	1997	9039259	No
135	4947	4947.0	0.0	0.0	Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.	J R Vane	Nat New Biol	1971	5284360	Yes
136	4924	4924.0	0.0	0.0	The assessment of anxiety states by rating.	M HAMILTON	Br J Med Psychol	1959	13638508	Yes
137	9832	4916.0	267.87	133.9	MRBAYES: Bayesian inference of phylogenetic trees.	J P Huelsenbeck, F Ronquist	Bioinformatics	2001	11524383	Yes
138	4883	4883.0	0.0	0.0	Development of a rating scale for primary depressive illness.	M Hamilton	Br J Soc Clin Psychol	1967	6080235	Yes
139	9760	4880.0	253.3	126.7	A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood.	Stéphane Guindon, Olivier Gascuel	Syst Biol	2003	14530136	Yes
140	4868	4868.0	132.34	132.3	Free radicals in the physiological control of cell function.	Wulf Dröge	Physiol Rev	2002	11773609	No
141	9649	4824.5	0.0	0.0	Continuous cultures of fused cells secreting antibody of predefined specificity.	G Köhler, C Milstein	Nature	1975	1172191	Yes
142	9610	4805.0	236.53	118.3	Dendritic cells and the control of immunity.	J Banchereau, R M Steinman	Nature	1998	9521319	No
143	9582	4791.0	0.0	0.0	Intraclass correlations: uses in assessing rater reliability.	P E Shrout, J L Fleiss	Psychol Bull	1979	18839484	No
144	9555	4777.5	411.7	205.8	The meaning and use of the area under a receiver operating characteristic (ROC) curve.	J A Hanley, B J McNeil	Radiology	1982	7063747	Yes
145	9553	4776.5	305.91	153.0	MODELTEST: testing the model of DNA substitution.	D Posada, K A Crandall	Bioinformatics	1998	9918953	Yes
146	9552	4776.0	233.43	116.7	One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.	K A Datsenko, B L Wanner	Proc Natl Acad Sci U S A	2000	10829079	Yes
147	4775	4775.0	0.0	0.0	Modification of seizure activity by electrical stimulation. II. Motor seizure.	R J Racine	Electroencephalogr Clin Neurophysiol	1972	4110397	Yes
148	9538	4769.0	0.0	0.0	Prediction of creatinine clearance from serum creatinine.	D W Cockcroft, M H Gault	Nephron	1976	1244564	Yes
149	9517	4758.5	0.0	0.0	Statistical aspects of the analysis of data from retrospective studies of disease.	N MANTEL, W HAENSZEL	J Natl Cancer Inst	1959	13655060	Yes
150	23509	4701.8	725.8	145.2	The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.	J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G Higgins	Nucleic Acids Res	1997	9396791	Yes
151	4689	4689.0	196.7	196.7	The Strengths and Difficulties Questionnaire: a research note.	R Goodman	J Child Psychol Psychiatry	1997	9255702	Yes
152	4685	4685.0	172.75	172.8	jModelTest: phylogenetic model averaging.	David Posada	Mol Biol Evol	2008	18397919	Yes
153	4680	4680.0	136.14	136.1	Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm.	T A Springer	Cell	1994	7507411	No
154	14034	4678.0	517.81	172.6	Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.	Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien	Ann Surg	2004	15273542	Yes
155	4664	4664.0	123.36	123.4	Antimicrobial peptides of multicellular organisms.	Michael Zasloff	Nature	2002	11807545	Yes
156	4653	4653.0	162.59	162.6	The steroid and thyroid hormone receptor superfamily.	R M Evans	Science	1988	3283939	No
157	9297	4648.5	0.0	0.0	Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.	Y Cheng, W H Prusoff	Biochem Pharmacol	1973	4202581	Yes
158	4623	4623.0	144.83	144.8	Inositol trisphosphate and calcium signalling.	M J Berridge	Nature	1993	8381210	No
159	4615	4615.0	124.79	124.8	Inflammation and metabolic disorders.	Gökhan S Hotamisligil	Nature	2006	17167474	No
160	4610	4610.0	114.66	114.7	Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis.	J Castresana	Mol Biol Evol	2000	10742046	Yes
161	13600	4533.3	0.0	0.0	Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.	H Ohkawa, N Ohishi, K Yagi	Anal Biochem	1979	36810	Yes
162	4522	4522.0	112.67	112.7	The biochemistry of apoptosis.	M O Hengartner	Nature	2000	11048727	No
163	4480	4480.0	245.45	245.4	UPARSE: highly accurate OTU sequences from microbial amplicon reads.	Robert C Edgar	Nat Methods	2013	23955772	Yes
164	4462	4462.0	94.39	94.4	Epithelial-mesenchymal transitions in tumour progression.	Jean Paul Thiery	Nat Rev Cancer	2002	12189386	No
165	8906	4453.0	258.16	129.1	Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features.	W Kabsch, C Sander	Biopolymers	1983	6667333	Yes
166	13257	4419.0	400.1	133.4	edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.	Mark D Robinson, Davis J McCarthy, Gordon K Smyth	Bioinformatics	2010	19910308	Yes
167	4416	4416.0	123.28	123.3	The NF-kappa B and I kappa B proteins: new discoveries and insights.	A S Baldwin	Annu Rev Immunol	1996	8717528	No
168	4395	4395.0	119.08	119.1	Rapid and efficient site-specific mutagenesis without phenotypic selection.	T A Kunkel	Proc Natl Acad Sci U S A	1985	3881765	Yes
169	17501	4375.2	594.34	148.6	MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0.	Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir Kumar	Mol Biol Evol	2007	17488738	Yes
170	4349	4349.0	148.19	148.2	Adhesion receptors of the immune system.	T A Springer	Nature	1990	1974032	No
171	4338	4338.0	95.29	95.3	Rho GTPases and the actin cytoskeleton.	A Hall	Science	1998	9438836	No
172	8655	4327.5	357.53	178.8	Three approaches to qualitative content analysis.	Hsiu-Fang Hsieh, Sarah E Shannon	Qual Health Res	2005	16204405	Yes
173	4326	4326.0	0.0	0.0	Aging: a theory based on free radical and radiation chemistry.	D HARMAN	J Gerontol	1956	13332224	Yes
174	4324	4324.0	0.0	0.0	Selective extraction of polyoma DNA from infected mouse cell cultures.	B Hirt	J Mol Biol	1967	4291934	Yes
175	4324	4324.0	129.78	129.8	Apoptosis in the pathogenesis and treatment of disease.	C B Thompson	Science	1995	7878464	No
176	8618	4309.0	214.32	107.2	Primer3 on the WWW for general users and for biologist programmers.	S Rozen, H Skaletsky	Methods Mol Biol	2000	10547847	Yes
177	4303	4303.0	155.04	155.0	Developments of a water-maze procedure for studying spatial learning in the rat.	R Morris	J Neurosci Methods	1984	6471907	Yes
178	4287	4287.0	119.26	119.3	Emotion circuits in the brain.	J E LeDoux	Annu Rev Neurosci	2000	10845062	No
179	4286	4286.0	134.02	134.0	A modified poisson regression approach to prospective studies with binary data.	Guangyong Zou	Am J Epidemiol	2004	15033648	Yes
180	4284	4284.0	0.0	0.0	THE ENVIRONMENT AND DISEASE: ASSOCIATION OR CAUSATION?	A B HILL	Proc R Soc Med	1965	14283879	Yes
181	4262	4262.0	0.0	0.0	The thiobarbituric acid assay of sialic acids.	L WARREN	J Biol Chem	1959	13672998	Yes
182	8514	4257.0	229.36	114.7	Comparative protein modelling by satisfaction of spatial restraints.	A Sali, T L Blundell	J Mol Biol	1993	8254673	Yes
183	12752	4250.7	478.23	159.4	A simple salting out procedure for extracting DNA from human nucleated cells.	S A Miller, D D Dykes, H F Polesky	Nucleic Acids Res	1988	3344216	Yes
184	12673	4224.3	455.01	151.7	The PHQ-9: validity of a brief depression severity measure.	K Kroenke, R L Spitzer, J B Williams	J Gen Intern Med	2001	11556941	Yes
185	4222	4222.0	0.0	0.0	Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues.	F Tietze	Anal Biochem	1969	4388022	Yes
186	16798	4199.5	0.0	0.0	Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.	J M Chirgwin, A E Przybyla, R J MacDonald, W J Rutter	Biochemistry	1979	518835	Yes
187	4180	4180.0	254.14	254.1	Prokka: rapid prokaryotic genome annotation.	Torsten Seemann	Bioinformatics	2014	24642063	Yes
188	12518	4172.7	339.81	113.3	Inference of population structure using multilocus genotype data.	J K Pritchard, M Stephens, P Donnelly	Genetics	2000	10835412	Yes
189	20784	4156.8	1176.25	235.2	MEGA6: Molecular Evolutionary Genetics Analysis version 6.0.	Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir Kumar	Mol Biol Evol	2013	24132122	Yes
190	4149	4149.0	132.51	132.5	A fast diffeomorphic image registration algorithm.	John Ashburner	Neuroimage	2007	17761438	Yes
191	4132	4132.0	0.0	0.0	A SELF-RATING DEPRESSION SCALE.	W W ZUNG	Arch Gen Psychiatry	1965	14221692	Yes
192	8253	4126.5	259.96	130.0	EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis.	Arnaud Delorme, Scott Makeig	J Neurosci Methods	2004	15102499	Yes
193	4121	4121.0	193.34	193.3	Orienting of attention.	M I Posner	Q J Exp Psychol	1980	7367577	Yes
194	4093	4093.0	131.24	131.2	G proteins: transducers of receptor-generated signals.	A G Gilman	Annu Rev Biochem	1987	3113327	No
195	8184	4092.0	256.97	128.5	Neuropathological stageing of Alzheimer-related changes.	H Braak, E Braak	Acta Neuropathol	1991	1759558	No
196	8143	4071.5	282.99	141.5	Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa.	H Schägger, G von Jagow	Anal Biochem	1987	2449095	Yes
197	8128	4064.0	192.43	96.2	Inflammation and cancer.	Lisa M Coussens, Zena Werb	Nature	2002	12490959	No
198	4055	4055.0	98.2	98.2	MUSCLE: a multiple sequence alignment method with reduced time and space complexity.	Robert C Edgar	BMC Bioinformatics	2004	15318951	Yes
199	4027	4027.0	297.8	297.8	SHELXT - integrated space-group and crystal-structure determination.	George M Sheldrick	Acta Crystallogr A Found Adv	2015	25537383	Yes
200	8051	4025.5	213.98	107.0	BEDTools: a flexible suite of utilities for comparing genomic features.	Aaron R Quinlan, Ira M Hall	Bioinformatics	2010	20110278	Yes
201	12031	4010.3	436.82	145.6	Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors.	C Yanisch-Perron, J Vieira, J Messing	Gene	1985	2985470	Yes
202	4000	4000.0	89.58	89.6	Targeting HIF-1 for cancer therapy.	Gregg L Semenza	Nat Rev Cancer	2003	13130303	No
203	7998	3999.0	194.81	97.4	The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.	John Hardy, Dennis J Selkoe	Science	2002	12130773	No
204	7963	3981.5	295.79	147.9	AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading.	Oleg Trott, Arthur J Olson	J Comput Chem	2010	19499576	Yes
205	3971	3971.0	79.23	79.2	DNA methylation patterns and epigenetic memory.	Adrian Bird	Genes Dev	2002	11782440	No
206	7906	3953.0	306.74	153.4	Operating characteristics of a rank correlation test for publication bias.	C B Begg, M Mazumdar	Biometrics	1994	7786990	Yes
207	7905	3952.5	230.49	115.2	Differential expression analysis for sequence count data.	Simon Anders, Wolfgang Huber	Genome Biol	2010	20979621	Yes
208	7904	3952.0	0.0	0.0	A series of normal stages in the development of the chick embryo.	V HAMBURGER, H L HAMILTON	J Morphol	1951	24539719	Yes
209	23707	3951.2	1075.79	179.3	MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods.	Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir Kumar	Mol Biol Evol	2011	21546353	Yes
210	3945	3945.0	140.93	140.9	New M13 vectors for cloning.	J Messing	Methods Enzymol	1983	6310323	Yes
211	11810	3936.7	281.03	93.7	Refinement of macromolecular structures by the maximum-likelihood method.	G N Murshudov, A A Vagin, E J Dodson	Acta Crystallogr D Biol Crystallogr	1997	15299926	Yes
212	23612	3935.3	1017.05	169.5	Global cancer statistics.	Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David Forman	CA Cancer J Clin	2011	21296855	Yes
213	7836	3918.0	0.0	0.0	A quantitative description of membrane current and its application to conduction and excitation in nerve.	A L HODGKIN, A F HUXLEY	J Physiol	1952	12991237	Yes
214	3905	3905.0	73.98	74.0	Generalized lacZ expression with the ROSA26 Cre reporter strain.	P Soriano	Nat Genet	1999	9916792	Yes
215	11690	3896.7	521.21	173.7	The positive and negative syndrome scale (PANSS) for schizophrenia.	S R Kay, A Fiszbein, L A Opler	Schizophr Bull	1987	3616518	Yes
216	3860	3860.0	121.87	121.9	The Cambridge Structural Database: a quarter of a million crystal structures and rising.	Frank H Allen	Acta Crystallogr B	2002	12037359	Yes
217	7714	3857.0	238.84	119.4	The rise of graphene.	A K Geim, K S Novoselov	Nat Mater	2007	17330084	Yes
218	3801	3801.0	101.22	101.2	An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.	M Kozak	Nucleic Acids Res	1987	3313277	No
219	3771	3771.0	92.44	92.4	Prions.	S B Prusiner	Proc Natl Acad Sci U S A	1998	9811807	No
220	3771	3771.0	85.88	85.9	Alternative activation of macrophages.	Siamon Gordon	Nat Rev Immunol	2003	12511873	No
221	3761	3761.0	0.0	0.0	Index for rating diagnostic tests.	W J YOUDEN	Cancer	1950	15405679	Yes
222	7502	3751.0	0.0	0.0	FUNCTIONAL EVALUATION: THE BARTHEL INDEX.	F I MAHONEY, D W BARTHEL	Md State Med J	1965	14258950	Yes
223	7493	3746.5	0.0	0.0	Assessment of older people: self-maintaining and instrumental activities of daily living.	M P Lawton, E M Brody	Gerontologist	1969	5349366	Yes
224	3745	3745.0	0.0	0.0	Mutation and cancer: statistical study of retinoblastoma.	A G Knudson	Proc Natl Acad Sci U S A	1971	5279523	Yes
225	7482	3741.0	0.0	0.0	A new depression scale designed to be sensitive to change.	S A Montgomery, M Asberg	Br J Psychiatry	1979	444788	Yes
226	3733	3733.0	92.48	92.5	Alzheimer's disease: genes, proteins, and therapy.	D J Selkoe	Physiol Rev	2001	11274343	No
227	3733	3733.0	115.19	115.2	Mild cognitive impairment as a diagnostic entity.	R C Petersen	J Intern Med	2004	15324362	No
228	3729	3729.0	0.0	0.0	Preparation of isolated rat liver cells.	P O Seglen	Methods Cell Biol	1976	177845	No
229	3725	3725.0	0.0	0.0	Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents.	M M Mesulam	J Histochem Cytochem	1978	24068	Yes
230	7416	3708.0	232.86	116.4	A synaptic model of memory: long-term potentiation in the hippocampus.	T V Bliss, G L Collingridge	Nature	1993	8421494	No
231	3686	3686.0	183.94	183.9	Revisiting the behavioral model and access to medical care: does it matter?	R M Andersen	J Health Soc Behav	1995	7738325	Yes
232	7354	3677.0	0.0	0.0	THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.	T OMURA, R SATO	J Biol Chem	1964	14209971	Yes
233	22057	3676.2	3207.3	534.6	Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.	Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal	CA Cancer J Clin	2018	30207593	Yes
234	7341	3670.5	190.83	95.4	SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling.	N Guex, M C Peitsch	Electrophoresis	1997	9504803	Yes
235	3662	3662.0	0.0	0.0	The McGill Pain Questionnaire: major properties and scoring methods.	Ronald Melzack	Pain	1975	1235985	Yes
236	7304	3652.0	343.41	171.7	The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.	R F Furchgott, J V Zawadzki	Nature	1980	6253831	Yes
237	10932	3644.0	861.34	287.1	Cancer statistics, 2016.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2016	26742998	Yes
238	3642	3642.0	81.47	81.5	Wnt/beta-catenin signaling in development and disease.	Hans Clevers	Cell	2006	17081971	No
239	3637	3637.0	116.06	116.1	How mitochondria produce reactive oxygen species.	Michael P Murphy	Biochem J	2009	19061483	No
240	3630	3630.0	88.9	88.9	Cancer cell cycles.	C J Sherr	Science	1996	8939849	No
241	3621	3621.0	0.0	0.0	The genetical evolution of social behaviour. I.	W D Hamilton	J Theor Biol	1964	5875341	Yes
242	10838	3612.7	377.9	126.0	A comprehensive set of sequence analysis programs for the VAX.	J Devereux, P Haeberli, O Smithies	Nucleic Acids Res	1984	6546423	Yes
243	3607	3607.0	75.3	75.3	The phosphoinositide 3-kinase pathway.	Lewis C Cantley	Science	2002	12040186	No
244	3606	3606.0	178.96	179.0	Oxygen-derived free radicals in postischemic tissue injury.	J M McCord	N Engl J Med	1985	2981404	No
245	17953	3590.6	0.0	0.0	An inventory for measuring depression.	A T BECK, C H WARD, M MENDELSON, J MOCK, J ERBAUGH	Arch Gen Psychiatry	1961	13688369	Yes
246	3583	3583.0	0.0	0.0	THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION.	P LAUREN	Acta Pathol Microbiol Scand	1965	14320675	Yes
247	3564	3564.0	155.39	155.4	An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies.	Peter C Austin	Multivariate Behav Res	2011	21818162	Yes
248	7105	3552.5	0.0	0.0	A new technique for the assay of infectivity of human adenovirus 5 DNA.	F L Graham, A J van der Eb	Virology	1973	4705382	Yes
249	7088	3544.0	180.45	90.2	Collective dynamics of 'small-world' networks.	D J Watts, S H Strogatz	Nature	1998	9623998	Yes
250	3533	3533.0	0.0	0.0	The detection of disease clustering and a generalized regression approach.	N Mantel	Cancer Res	1967	6018555	Yes
251	7026	3513.0	229.47	114.7	Improved tools for biological sequence comparison.	W R Pearson, D J Lipman	Proc Natl Acad Sci U S A	1988	3162770	Yes
252	3512	3512.0	93.96	94.0	Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.	M Kozak	Cell	1986	3943125	Yes
253	3501	3501.0	83.38	83.4	PAML: a program package for phylogenetic analysis by maximum likelihood.	Z Yang	Comput Appl Biosci	1997	9367129	Yes
254	13890	3472.5	533.81	133.5	G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences.	Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner	Behav Res Methods	2007	17695343	Yes
255	3472	3472.0	81.8	81.8	Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.	C J Marshall	Cell	1995	7834738	No
256	3467	3467.0	141.11	141.1	Studies and perspectives of protein kinase C.	Y Nishizuka	Science	1986	3014651	No
257	3465	3465.0	0.0	0.0	The clonal evolution of tumor cell populations.	P C Nowell	Science	1976	959840	Yes
258	10385	3461.7	539.62	179.9	Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.	S M Hsu, L Raine, H Fanger	J Histochem Cytochem	1981	6166661	Yes
259	6909	3454.5	167.15	83.6	MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification.	Jürgen Cox, Matthias Mann	Nat Biotechnol	2008	19029910	Yes
260	6884	3442.0	194.06	97.0	A genetic model for colorectal tumorigenesis.	E R Fearon, B Vogelstein	Cell	1990	2188735	No
261	3426	3426.0	124.57	124.6	Updating P300: an integrative theory of P3a and P3b.	John Polich	Clin Neurophysiol	2007	17573239	No
262	3420	3420.0	90.18	90.2	Mechanisms of angiogenesis.	W Risau	Nature	1997	9109485	No
263	3405	3405.0	114.48	114.5	A new method for predicting signal sequence cleavage sites.	G von Heijne	Nucleic Acids Res	1986	3714490	Yes
264	10207	3402.3	463.08	154.4	Nitric oxide: physiology, pathophysiology, and pharmacology.	S Moncada, R M Palmer, E A Higgs	Pharmacol Rev	1991	1852778	No
265	6790	3395.0	152.14	76.1	A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.	R S Sikorski, P Hieter	Genetics	1989	2659436	Yes
266	6771	3385.5	250.47	125.2	DnaSP v5: a software for comprehensive analysis of DNA polymorphism data.	P Librado, J Rozas	Bioinformatics	2009	19346325	Yes
267	3382	3382.0	0.0	0.0	Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation.	W H Harris	J Bone Joint Surg Am	1969	5783851	Yes
268	3376	3376.0	80.76	80.8	Tandem repeats finder: a program to analyze DNA sequences.	G Benson	Nucleic Acids Res	1999	9862982	Yes
269	10107	3369.0	954.39	318.1	Cancer Statistics, 2017.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2017	28055103	Yes
270	3364	3364.0	150.49	150.5	EuroQol: the current state of play.	R Brooks	Health Policy	1996	10158943	No
271	3361	3361.0	0.0	0.0	Estimation of nuclear population from microtome sections.	M ABERCROMBIE	Anat Rec	1946	21015608	Yes
272	6706	3353.0	0.0	0.0	Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).	J M McCord, I Fridovich	J Biol Chem	1969	5389100	Yes
273	3353	3353.0	0.0	0.0	THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS.	L HAYFLICK	Exp Cell Res	1965	14315085	Yes
274	6697	3348.5	208.06	104.0	Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy.	Florian Weigend, Reinhart Ahlrichs	Phys Chem Chem Phys	2005	16240044	Yes
275	3344	3344.0	97.98	98.0	Staphylococcus aureus infections.	F D Lowy	N Engl J Med	1998	9709046	No
276	3343	3343.0	90.39	90.4	ras oncogenes in human cancer: a review.	J L Bos	Cancer Res	1989	2547513	No
277	3343	3343.0	99.1	99.1	Sequencing technologies - the next generation.	Michael L Metzker	Nat Rev Genet	2010	19997069	No
278	13367	3341.8	0.0	0.0	A new and rapid colorimetric determination of acetylcholinesterase activity.	G L ELLMAN, K D COURTNEY, V ANDRES, R M FEATHER-STONE	Biochem Pharmacol	1961	13726518	Yes
279	3339	3339.0	143.14	143.1	Whatever happened to qualitative description?	M Sandelowski	Res Nurs Health	2000	10940958	No
280	13318	3329.5	409.05	102.3	Features and development of Coot.	P Emsley, B Lohkamp, W G Scott, K Cowtan	Acta Crystallogr D Biol Crystallogr	2010	20383002	Yes
281	6646	3323.0	133.03	66.5	Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.	A H Brand, N Perrimon	Development	1993	8223268	Yes
282	19858	3309.7	794.23	132.4	Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.	D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C Turner	Diabetologia	1985	3899825	Yes
283	3307	3307.0	80.69	80.7	Atherosclerosis.	A J Lusis	Nature	2000	11001066	No
284	6604	3302.0	0.0	0.0	Parkinsonism: onset, progression and mortality.	M M Hoehn, M D Yahr	Neurology	1967	6067254	Yes
285	3302	3302.0	84.29	84.3	Apoptosis by death factor.	S Nagata	Cell	1997	9039262	No
286	6598	3299.0	0.0	0.0	A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.	W M Bonner, R A Laskey	Eur J Biochem	1974	4850204	Yes
287	3285	3285.0	79.02	79.0	Protein production by auto-induction in high density shaking cultures.	F William Studier	Protein Expr Purif	2005	15915565	Yes
288	3280	3280.0	74.37	74.4	The green fluorescent protein.	R Y Tsien	Annu Rev Biochem	1998	9759496	No
289	6520	3260.0	211.03	105.5	RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome.	Bo Li, Colin N Dewey	BMC Bioinformatics	2011	21816040	Yes
290	3259	3259.0	73.01	73.0	Protein secondary structure prediction based on position-specific scoring matrices.	D T Jones	J Mol Biol	1999	10493868	Yes
291	6507	3253.5	177.26	88.6	tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence.	T M Lowe, S R Eddy	Nucleic Acids Res	1997	9023104	Yes
292	12999	3249.8	393.62	98.4	Global cancer statistics, 2002.	D Max Parkin, Freddie Bray, J Ferlay, Paola Pisani	CA Cancer J Clin	2005	15761078	Yes
293	3244	3244.0	123.9	123.9	Glutamate neurotoxicity and diseases of the nervous system.	D W Choi	Neuron	1988	2908446	No
294	3238	3238.0	126.76	126.8	Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.	P Matsudaira	J Biol Chem	1987	3611052	Yes
295	3238	3238.0	84.42	84.4	Why most published research findings are false.	John P A Ioannidis	PLoS Med	2005	16060722	Yes
296	3235	3235.0	133.55	133.6	ANALYZING TABLES OF STATISTICAL TESTS.	William R Rice	Evolution	1989	28568501	Yes
297	6468	3234.0	0.0	0.0	Assessment of coma and impaired consciousness. A practical scale.	G Teasdale, B Jennett	Lancet	1974	4136544	Yes
298	6463	3231.5	207.61	103.8	BEAST: Bayesian evolutionary analysis by sampling trees.	Alexei J Drummond, Andrew Rambaut	BMC Evol Biol	2007	17996036	Yes
299	3225	3225.0	94.87	94.9	Multiple sequence alignment with hierarchical clustering.	F Corpet	Nucleic Acids Res	1988	2849754	Yes
300	3225	3225.0	101.8	101.8	Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing.	S Henikoff	Gene	1984	6235151	Yes
301	6449	3224.5	281.93	141.0	Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness.	U H Graneheim, B Lundman	Nurse Educ Today	2004	14769454	No
302	3219	3219.0	74.14	74.1	The retinoblastoma protein and cell cycle control.	R A Weinberg	Cell	1995	7736585	No
303	3211	3211.0	0.0	0.0	The need for a new medical model: a challenge for biomedicine.	G L Engel	Science	1977	847460	Yes
304	6417	3208.5	339.99	170.0	Ligand: a versatile computerized approach for characterization of ligand-binding systems.	P J Munson, D Rodbard	Anal Biochem	1980	6254391	Yes
305	3206	3206.0	0.0	0.0	Bone: formation by autoinduction.	M R Urist	Science	1965	5319761	Yes
306	3203	3203.0	150.31	150.3	The pathogenesis of atherosclerosis--an update.	R Ross	N Engl J Med	1986	3511384	No
307	3187	3187.0	76.61	76.6	Scaling and assessment of data quality.	Philip Evans	Acta Crystallogr D Biol Crystallogr	2006	16369096	No
308	3183	3183.0	105.85	105.8	Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C.	Y Nishizuka	Science	1992	1411571	No
309	3182	3182.0	0.0	0.0	Evolution in Mendelian Populations.	S Wright	Genetics	1931	17246615	Yes
310	3170	3170.0	98.28	98.3	Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group.	R B D'Agostino	Stat Med	1998	9802183	Yes
311	3165	3165.0	72.17	72.2	TGF-beta signal transduction.	J Massagué	Annu Rev Biochem	1998	9759503	No
312	6307	3153.5	277.15	138.6	Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models.	Kristopher J Preacher, Andrew F Hayes	Behav Res Methods	2008	18697684	Yes
313	3148	3148.0	102.13	102.1	Revisions in the International System for Staging Lung Cancer.	C F Mountain	Chest	1997	9187198	Yes
314	3147	3147.0	82.95	83.0	Nonalcoholic fatty liver disease.	Paul Angulo	N Engl J Med	2002	11961152	No
315	3146	3146.0	77.39	77.4	Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.	Rakesh K Jain	Science	2005	15637262	No
316	3136	3136.0	90.52	90.5	The dendritic cell system and its role in immunogenicity.	R M Steinman	Annu Rev Immunol	1991	1910679	No
317	9390	3130.0	470.52	156.8	Cancer statistics, 2013.	Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal	CA Cancer J Clin	2013	23335087	Yes
318	9388	3129.3	436.17	145.4	A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity.	J Ware, M Kosinski, S D Keller	Med Care	1996	8628042	Yes
319	6235	3117.5	181.34	90.7	Control of goal-directed and stimulus-driven attention in the brain.	Maurizio Corbetta, Gordon L Shulman	Nat Rev Neurosci	2002	11994752	No
320	3116	3116.0	113.29	113.3	genepop'007: a complete re-implementation of the genepop software for Windows and Linux.	François Rousset	Mol Ecol Resour	2008	21585727	Yes
321	3115	3115.0	82.15	82.2	Marrow stromal cells as stem cells for nonhematopoietic tissues.	D J Prockop	Science	1997	9082988	No
322	3111	3111.0	67.6	67.6	Hypoxia--a key regulatory factor in tumour growth.	Adrian L Harris	Nat Rev Cancer	2002	11902584	No
323	9317	3105.7	1230.9	410.3	Cancer statistics, 2018.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2018	29313949	Yes
324	6196	3098.0	193.25	96.6	Ab initio molecular dynamics for liquid metals.	Kresse, Hafner	Phys Rev B Condens Matter	1993	10004490	Yes
325	3096	3096.0	114.65	114.7	How do you feel--now? The anterior insula and human awareness.	A D Bud Craig	Nat Rev Neurosci	2009	19096369	No
326	6173	3086.5	151.97	76.0	Functional rafts in cell membranes.	K Simons, E Ikonen	Nature	1997	9177342	No
327	3073	3073.0	0.0	0.0	A rapid banding technique for human chromosomes.	M Seabright	Lancet	1971	4107917	Yes
328	9192	3064.0	230.74	76.9	Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.	J D Dignam, R M Lebovitz, R G Roeder	Nucleic Acids Res	1983	6828386	Yes
329	6120	3060.0	171.83	85.9	Mitochondria and apoptosis.	D R Green, J C Reed	Science	1998	9721092	No
330	3058	3058.0	136.43	136.4	Measuring the accuracy of diagnostic systems.	J A Swets	Science	1988	3287615	No
331	9172	3057.3	0.0	0.0	Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.	W H Habig, M J Pabst, W B Jakoby	J Biol Chem	1974	4436300	Yes
332	3056	3056.0	83.63	83.6	Cancer. p53, guardian of the genome.	D P Lane	Nature	1992	1614522	No
333	3048	3048.0	66.49	66.5	Mammalian neural stem cells.	F H Gage	Science	2000	10688783	No
334	9130	3043.3	478.07	159.4	Development and validation of brief measures of positive and negative affect: the PANAS scales.	D Watson, L A Clark, A Tellegen	J Pers Soc Psychol	1988	3397865	Yes
335	3041	3041.0	70.75	70.8	Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.	G R Martin	Proc Natl Acad Sci U S A	1981	6950406	Yes
336	6078	3039.0	0.0	0.0	Radiological assessment of osteo-arthrosis.	J H KELLGREN, J S LAWRENCE	Ann Rheum Dis	1957	13498604	Yes
337	6066	3033.0	0.0	0.0	Microsomal lipid peroxidation.	J A Buege, S D Aust	Methods Enzymol	1978	672633	Yes
338	3027	3027.0	91.97	92.0	The adolescent brain and age-related behavioral manifestations.	L P Spear	Neurosci Biobehav Rev	2000	10817843	No
339	3023	3023.0	83.62	83.6	Caspases: the executioners of apoptosis.	G M Cohen	Biochem J	1997	9337844	No
340	3015	3015.0	0.0	0.0	A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients.	E Pfeiffer	J Am Geriatr Soc	1975	1159263	Yes
341	3014	3014.0	0.0	0.0	Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.	C B Laurell	Anal Biochem	1966	5959431	Yes
342	3008	3008.0	0.0	0.0	Principles that govern the folding of protein chains.	C B Anfinsen	Science	1973	4124164	Yes
343	3007	3007.0	0.0	0.0	A membrane-filter technique for the detection of complementary DNA.	D T Denhardt	Biochem Biophys Res Commun	1966	5963888	Yes
344	9018	3006.0	588.51	196.2	Cancer statistics, 2015.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2015	25559415	Yes
345	3002	3002.0	87.62	87.6	Microglia: a sensor for pathological events in the CNS.	G W Kreutzberg	Trends Neurosci	1996	8843599	No
346	5980	2990.0	186.52	93.3	Velvet: algorithms for de novo short read assembly using de Bruijn graphs.	Daniel R Zerbino, Ewan Birney	Genome Res	2008	18349386	Yes
347	2977	2977.0	62.08	62.1	Signal transduction by the JNK group of MAP kinases.	R J Davis	Cell	2000	11057897	No
348	11905	2976.2	312.33	78.1	Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.	Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg	Genome Biol	2009	19261174	Yes
349	2975	2975.0	0.0	0.0	METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS.	M RODBELL	J Biol Chem	1964	14169133	Yes
350	2974	2974.0	116.06	116.1	Bacterial evolution.	C R Woese	Microbiol Rev	1987	2439888	No
351	5932	2966.0	299.54	149.8	The timed "Up & Go": a test of basic functional mobility for frail elderly persons.	D Podsiadlo, S Richardson	J Am Geriatr Soc	1991	1991946	Yes
352	2966	2966.0	0.0	0.0	Determination of protein: a modification of the Lowry method that gives a linear photometric response.	E F Hartree	Anal Biochem	1972	4115981	Yes
353	2965	2965.0	101.61	101.6	Soft self-consistent pseudopotentials in a generalized eigenvalue formalism.	Vanderbilt	Phys Rev B Condens Matter	1990	9993096	Yes
354	2959	2959.0	101.67	101.7	What's wrong with Bonferroni adjustments.	T V Perneger	BMJ	1998	9553006	No
355	2958	2958.0	85.03	85.0	Oxidative stress, antioxidants and stress tolerance.	Ron Mittler	Trends Plant Sci	2002	12234732	No
356	2952	2952.0	98.24	98.2	Graphene: status and prospects.	A K Geim	Science	2009	19541989	Yes
357	2950	2950.0	104.5	104.5	The molecular heterogeneity of protein kinase C and its implications for cellular regulation.	Y Nishizuka	Nature	1988	3045562	No
358	5898	2949.0	112.69	56.3	Translating the histone code.	T Jenuwein, C D Allis	Science	2001	11498575	No
359	2947	2947.0	64.9	64.9	Profile hidden Markov models.	S R Eddy	Bioinformatics	1998	9918945	No
360	2947	2947.0	82.36	82.4	I-TASSER server for protein 3D structure prediction.	Yang Zhang	BMC Bioinformatics	2008	18215316	Yes
361	17680	2946.7	1184.76	197.5	Global cancer statistics, 2012.	Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin Jemal	CA Cancer J Clin	2015	25651787	Yes
362	2945	2945.0	102.28	102.3	Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation.	A H Wyllie	Nature	1980	6245367	Yes
363	2945	2945.0	82.5	82.5	Novel proteinaceous infectious particles cause scrapie.	S B Prusiner	Science	1982	6801762	Yes
364	2944	2944.0	134.94	134.9	A concordance correlation coefficient to evaluate reproducibility.	L I Lin	Biometrics	1989	2720055	Yes
365	5864	2932.0	170.28	85.1	Genomic sequencing.	G M Church, W Gilbert	Proc Natl Acad Sci U S A	1984	6326095	Yes
366	2932	2932.0	114.71	114.7	Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD.	Russell A Barkley	Psychol Bull	1997	9000892	No
367	5861	2930.5	165.41	82.7	An integrative theory of prefrontal cortex function.	E K Miller, J D Cohen	Annu Rev Neurosci	2001	11283309	No
368	2930	2930.0	77.49	77.5	Glutamate uptake.	N C Danbolt	Prog Neurobiol	2001	11369436	No
369	2929	2929.0	72.14	72.1	Instability and decay of the primary structure of DNA.	T Lindahl	Nature	1993	8469282	No
370	2924	2924.0	0.0	0.0	The Scree Test For The Number Of Factors.	R B Cattell	Multivariate Behav Res	1966	26828106	Yes
371	2917	2917.0	101.94	101.9	Protective and damaging effects of stress mediators.	B S McEwen	N Engl J Med	1998	9428819	No
372	11640	2910.0	529.89	132.5	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	Ann Intern Med	2009	19622511	No
373	2905	2905.0	0.0	0.0	Transformed up-down methods in psychoacoustics.	H Levitt	J Acoust Soc Am	1971	5541744	Yes
374	2898	2898.0	97.93	97.9	What is the evidence that tumors are angiogenesis dependent?	J Folkman	J Natl Cancer Inst	1990	1688381	No
375	2897	2897.0	111.8	111.8	Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence.	Ilan H Meyer	Psychol Bull	2003	12956539	No
376	2882	2882.0	84.64	84.6	Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?	Kim A Brogden	Nat Rev Microbiol	2005	15703760	No
377	5758	2879.0	0.0	0.0	Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.	D E Paglia, W N Valentine	J Lab Clin Med	1967	6066618	Yes
378	8631	2877.0	325.2	108.4	Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.	E R DeLong, D M DeLong, D L Clarke-Pearson	Biometrics	1988	3203132	Yes
379	5754	2877.0	123.32	61.7	Statistical significance for genomewide studies.	John D Storey, Robert Tibshirani	Proc Natl Acad Sci U S A	2003	12883005	Yes
380	2876	2876.0	0.0	0.0	New methods for calculating metabolic rate with special reference to protein metabolism.	J B DE B WEIR	J Physiol	1949	15394301	Yes
381	2874	2874.0	110.04	110.0	Modeling valuations for EuroQol health states.	P Dolan	Med Care	1997	9366889	Yes
382	2864	2864.0	0.0	0.0	Amino acid metabolism in mammalian cell cultures.	H EAGLE	Science	1959	13675766	Yes
383	2863	2863.0	0.0	0.0	Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit.	J Cohen	Psychol Bull	1968	19673146	Yes
384	5720	2860.0	266.78	133.4	The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay.	I F Benzie, J J Strain	Anal Biochem	1996	8660627	Yes
385	2859	2859.0	82.53	82.5	The origins and the future of microfluidics.	George M Whitesides	Nature	2006	16871203	No
386	2856	2856.0	0.0	0.0	Estimation of average heterozygosity and genetic distance from a small number of individuals.	M Nei	Genetics	1978	17248844	Yes
387	8553	2851.0	392.38	130.8	Cancer statistics, 2012.	Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal	CA Cancer J Clin	2012	22237781	Yes
388	2833	2833.0	79.48	79.5	ras genes.	M Barbacid	Annu Rev Biochem	1987	3304147	No
389	8498	2832.7	0.0	0.0	Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.	J F Kerr, A H Wyllie, A R Currie	Br J Cancer	1972	4561027	No
390	5657	2828.5	231.48	115.7	Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows.	Laurent Excoffier, Heidi E L Lischer	Mol Ecol Resour	2010	21565059	Yes
391	2817	2817.0	69.93	69.9	Folding DNA to create nanoscale shapes and patterns.	Paul W K Rothemund	Nature	2006	16541064	Yes
392	2812	2812.0	118.05	118.0	Tissue destruction by neutrophils.	S J Weiss	N Engl J Med	1989	2536474	No
393	5618	2809.0	162.63	81.3	The basics of epithelial-mesenchymal transition.	Raghu Kalluri, Robert A Weinberg	J Clin Invest	2009	19487818	No
394	5598	2799.0	142.13	71.1	Inference of macromolecular assemblies from crystalline state.	Evgeny Krissinel, Kim Henrick	J Mol Biol	2007	17681537	Yes
395	2798	2798.0	82.46	82.5	A catalogue of splice junction sequences.	S M Mount	Nucleic Acids Res	1982	7063411	Yes
396	5591	2795.5	182.47	91.2	ESTIMATING F-STATISTICS FOR THE ANALYSIS OF POPULATION STRUCTURE.	B S Weir, C Clark Cockerham	Evolution	1984	28563791	Yes
397	2795	2795.0	0.0	0.0	Generalized expectancies for internal versus external control of reinforcement.	J B Rotter	Psychol Monogr	1966	5340840	No
398	2788	2788.0	78.18	78.2	The basis of anisotropic water diffusion in the nervous system - a technical review.	Christian Beaulieu	NMR Biomed	2002	12489094	No
399	2782	2782.0	102.54	102.5	Development of a classification system for periodontal diseases and conditions.	G C Armitage	Ann Periodontol	1999	10863370	No
400	2772	2772.0	0.0	0.0	The determination of enzyme inhibitor constants.	M DIXON	Biochem J	1953	13093635	Yes
401	5537	2768.5	111.76	55.9	The ubiquitin system.	A Hershko, A Ciechanover	Annu Rev Biochem	1998	9759494	No
402	2762	2762.0	0.0	0.0	Aggregation of blood platelets by adenosine diphosphate and its reversal.	G V BORN	Nature	1962	13871375	Yes
403	2754	2754.0	98.44	98.4	Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans.	L R Squire	Psychol Rev	1992	1594723	No
404	8251	2750.3	409.13	136.4	A global measure of perceived stress.	S Cohen, T Kamarck, R Mermelstein	J Health Soc Behav	1983	6668417	Yes
405	2747	2747.0	0.0	0.0	Observational study of behavior: sampling methods.	J Altmann	Behaviour	1974	4597405	No
406	13716	2743.2	512.37	102.5	Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.	O P Hamill, A Marty, E Neher, B Sakmann, F J Sigworth	Pflugers Arch	1981	6270629	Yes
407	2743	2743.0	94.2	94.2	Biological roles of oligosaccharides: all of the theories are correct.	A Varki	Glycobiology	1993	8490246	No
408	2742	2742.0	94.58	94.6	Functions of DNA methylation: islands, start sites, gene bodies and beyond.	Peter A Jones	Nat Rev Genet	2012	22641018	No
409	2736	2736.0	65.2	65.2	Activators and target genes of Rel/NF-kappaB transcription factors.	H L Pahl	Oncogene	1999	10602461	No
410	8186	2728.7	176.58	58.9	Significance analysis of microarrays applied to the ionizing radiation response.	V G Tusher, R Tibshirani, G Chu	Proc Natl Acad Sci U S A	2001	11309499	Yes
411	2717	2717.0	94.82	94.8	Integrins: a family of cell surface receptors.	R O Hynes	Cell	1987	3028640	No
412	2716	2716.0	77.48	77.5	How do you feel? Interoception: the sense of the physiological condition of the body.	A D Craig	Nat Rev Neurosci	2002	12154366	No
413	2707	2707.0	112.22	112.2	Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity.	J H Morrissey	Anal Biochem	1981	6172996	Yes
414	8116	2705.3	182.55	60.9	Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.	Benjamin P Lewis, Christopher B Burge, David P Bartel	Cell	2005	15652477	Yes
415	2701	2701.0	78.28	78.3	Free R value: a novel statistical quantity for assessing the accuracy of crystal structures.	A T Brünger	Nature	1992	18481394	Yes
416	2699	2699.0	72.31	72.3	Wound healing--aiming for perfect skin regeneration.	P Martin	Science	1997	9082989	No
417	2699	2699.0	54.79	54.8	Cell signaling by receptor tyrosine kinases.	J Schlessinger	Cell	2000	11057895	No
418	2699	2699.0	0.0	0.0	Staining of tissue sections for electron microscopy with heavy metals.	M L WATSON	J Biophys Biochem Cytol	1958	13563554	Yes
419	18892	2698.9	459.29	65.6	UCSF Chimera--a visualization system for exploratory research and analysis.	Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin	J Comput Chem	2004	15264254	Yes
420	2688	2688.0	0.0	0.0	Basic principles of ROC analysis.	C E Metz	Semin Nucl Med	1978	112681	Yes
421	2688	2688.0	59.39	59.4	STATs and gene regulation.	J E Darnell	Science	1997	9287210	No
422	5375	2687.5	140.71	70.4	The plant immune system.	Jonathan D G Jones, Jeffery L Dangl	Nature	2006	17108957	No
423	2687	2687.0	76.95	77.0	Neural networks and physical systems with emergent collective computational abilities.	J J Hopfield	Proc Natl Acad Sci U S A	1982	6953413	Yes
424	5357	2678.5	223.13	111.6	Management of hepatocellular carcinoma: an update.	Jordi Bruix, Morris Sherman	Hepatology	2011	21374666	No
425	2672	2672.0	76.58	76.6	The pathobiology of diabetic complications: a unifying mechanism.	Michael Brownlee	Diabetes	2005	15919781	No
426	5337	2668.5	133.52	66.8	WGCNA: an R package for weighted correlation network analysis.	Peter Langfelder, Steve Horvath	BMC Bioinformatics	2008	19114008	Yes
427	7970	2656.7	217.07	72.4	Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists.	Da Wei Huang, Brad T Sherman, Richard A Lempicki	Nucleic Acids Res	2009	19033363	Yes
428	5312	2656.0	124.77	62.4	Toll-like receptor signalling.	Shizuo Akira, Kiyoshi Takeda	Nat Rev Immunol	2004	15229469	No
429	2653	2653.0	102.38	102.4	Emerging adulthood. A theory of development from the late teens through the twenties.	J J Arnett	Am Psychol	2000	10842426	Yes
430	10604	2651.0	284.19	71.0	Haploview: analysis and visualization of LD and haplotype maps.	J C Barrett, B Fry, J Maller, M J Daly	Bioinformatics	2005	15297300	Yes
431	2646	2646.0	69.43	69.4	Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies.	Ting-Chao Chou	Pharmacol Rev	2006	16968952	No
432	2645	2645.0	61.36	61.4	Somatic generation of antibody diversity.	S Tonegawa	Nature	1983	6300689	No
433	2643	2643.0	56.83	56.8	The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited.	Isaiah J Fidler	Nat Rev Cancer	2003	12778135	No
434	5278	2639.0	0.0	0.0	Preparation of iodine-131 labelled human growth hormone of high specific activity.	W M HUNTER, F C GREENWOOD	Nature	1962	14450081	Yes
435	2636	2636.0	84.61	84.6	EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis.	W Klimesch	Brain Res Brain Res Rev	1999	10209231	No
436	2632	2632.0	69.97	70.0	The scanning model for translation: an update.	M Kozak	J Cell Biol	1989	2645293	No
437	5261	2630.5	128.19	64.1	MicroRNA signatures in human cancers.	George A Calin, Carlo M Croce	Nat Rev Cancer	2006	17060945	No
438	2623	2623.0	0.0	0.0	The colorimetric estimation of formaldehyde by means of the Hantzsch reaction.	T NASH	Biochem J	1953	13105648	Yes
439	7867	2622.3	1719.4	573.1	Cancer statistics, 2019.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2019	30620402	Yes
440	2606	2606.0	81.29	81.3	Hay fever, hygiene, and household size.	D P Strachan	BMJ	1989	2513902	Yes
441	5212	2606.0	124.99	62.5	Angiogenesis in cancer and other diseases.	P Carmeliet, R K Jain	Nature	2000	11001068	No
442	2604	2604.0	60.93	60.9	Protein folding and misfolding.	Christopher M Dobson	Nature	2003	14685248	No
443	2602	2602.0	132.04	132.0	Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine.	O W Griffith	Anal Biochem	1980	7416462	Yes
444	2597	2597.0	73.13	73.1	WHAT IF: a molecular modeling and drug design program.	G Vriend	J Mol Graph	1990	2268628	Yes
445	10386	2596.5	290.79	72.7	Improved methods for building protein models in electron density maps and the location of errors in these models.	T A Jones, J Y Zou, S W Cowan, M Kjeldgaard	Acta Crystallogr A	1991	2025413	Yes
446	7773	2591.0	0.0	0.0	Determination of serum proteins by means of the biuret reaction.	A G GORNALL, C J BARDAWILL, M M DAVID	J Biol Chem	1949	18110453	Yes
447	2583	2583.0	79.63	79.6	Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection.	Y X Fu	Genetics	1997	9335623	Yes
448	2578	2578.0	79.11	79.1	Mesenchymal stem cells.	A I Caplan	J Orthop Res	1991	1870029	Yes
449	5139	2569.5	0.0	0.0	Receptive fields, binocular interaction and functional architecture in the cat's visual cortex.	D H HUBEL, T N WIESEL	J Physiol	1962	14449617	Yes
450	2568	2568.0	104.69	104.7	Nitric oxide as a secretory product of mammalian cells.	C Nathan	FASEB J	1992	1381691	No
451	2566	2566.0	0.0	0.0	[A micro-method of immuno-electrophoresis].	J J SCHEIDEGGER	Int Arch Allergy Appl Immunol	1955	13262900	Yes
452	2563	2563.0	156.99	157.0	Executive functions.	Adele Diamond	Annu Rev Psychol	2013	23020641	No
453	2558	2558.0	64.27	64.3	Tolerance, danger, and the extended family.	P Matzinger	Annu Rev Immunol	1994	8011301	No
454	2555	2555.0	89.97	90.0	Hepatocellular carcinoma.	Hashem B El-Serag	N Engl J Med	2011	21992124	No
455	5107	2553.5	147.96	74.0	Voxel-based morphometry--the methods.	J Ashburner, K J Friston	Neuroimage	2000	10860804	No
456	5100	2550.0	2257.72	1128.9	Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention.	Zunyou Wu, Jennifer M McGoogan	JAMA	2020	32091533	Yes
457	2549	2549.0	73.24	73.2	Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.	M Kozak	Nucleic Acids Res	1984	6694911	Yes
458	2548	2548.0	78.05	78.0	The heat-shock response.	S Lindquist	Annu Rev Biochem	1986	2427013	No
459	2548	2548.0	65.58	65.6	Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.	H F Dvorak	N Engl J Med	1986	3537791	No
460	2548	2548.0	0.0	0.0	The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid.	J F WOESSNER	Arch Biochem Biophys	1961	13786180	Yes
461	2546	2546.0	85.36	85.4	Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.	R W Mahley	Science	1988	3283935	No
462	7634	2544.7	197.94	66.0	TopHat: discovering splice junctions with RNA-Seq.	Cole Trapnell, Lior Pachter, Steven L Salzberg	Bioinformatics	2009	19289445	Yes
463	5089	2544.5	94.62	47.3	The language of covalent histone modifications.	B D Strahl, C D Allis	Nature	2000	10638745	Yes
464	2544	2544.0	78.96	79.0	Drug combination studies and their synergy quantification using the Chou-Talalay method.	Ting-Chao Chou	Cancer Res	2010	20068163	Yes
465	2541	2541.0	67.17	67.2	Photoelectrochemical cells.	M Grätzel	Nature	2001	11713540	Yes
466	2541	2541.0	57.46	57.5	Alzheimer's disease is a synaptic failure.	Dennis J Selkoe	Science	2002	12399581	No
467	2537	2537.0	95.65	95.7	Health promotion by social cognitive means.	Albert Bandura	Health Educ Behav	2004	15090118	Yes
468	2534	2534.0	60.35	60.4	Angiogenesis in health and disease.	Peter Carmeliet	Nat Med	2003	12778163	No
469	2524	2524.0	60.5	60.5	Cardiac excitation-contraction coupling.	Donald M Bers	Nature	2002	11805843	No
470	2517	2517.0	86.7	86.7	Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis.	Thomas Welton	Chem Rev	1999	11849019	Yes
471	5033	2516.5	0.0	0.0	Human malaria parasites in continuous culture.	W Trager, J B Jensen	Science	1976	781840	Yes
472	5012	2506.0	135.91	68.0	Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase.	C Tuerk, L Gold	Science	1990	2200121	Yes
473	5011	2505.5	164.55	82.3	Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis.	S Duval, R Tweedie	Biometrics	2000	10877304	Yes
474	2505	2505.0	51.06	51.1	Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling.	P Schuck	Biophys J	2000	10692345	Yes
475	2505	2505.0	78.5	78.5	Non-coding RNAs in human disease.	Manel Esteller	Nat Rev Genet	2011	22094949	No
476	2503	2503.0	96.15	96.2	No adjustments are needed for multiple comparisons.	K J Rothman	Epidemiology	1990	2081237	Yes
477	2501	2501.0	50.96	51.0	RNA interference.	Gregory J Hannon	Nature	2002	12110901	No
478	4996	2498.0	157.11	78.6	Projections of global mortality and burden of disease from 2002 to 2030.	Colin D Mathers, Dejan Loncar	PLoS Med	2006	17132052	Yes
479	9963	2490.8	373.4	93.3	Cancer statistics, 2010.	Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth Ward	CA Cancer J Clin	2010	20610543	Yes
480	2490	2490.0	73.04	73.0	Biologic basis for interleukin-1 in disease.	C A Dinarello	Blood	1996	8630372	No
481	2486	2486.0	81.91	81.9	ABC transporters: from microorganisms to man.	C F Higgins	Annu Rev Cell Biol	1992	1282354	No
482	2486	2486.0	59.64	59.6	Mechanisms of angiogenesis and arteriogenesis.	P Carmeliet	Nat Med	2000	10742145	No
483	2483	2483.0	0.0	0.0	DISC ELECTROPHORESIS. I. BACKGROUND AND THEORY.	L ORNSTEIN	Ann N Y Acad Sci	1964	14240533	Yes
484	4958	2479.0	120.12	60.1	Oncomirs - microRNAs with a role in cancer.	Aurora Esquela-Kerscher, Frank J Slack	Nat Rev Cancer	2006	16557279	No
485	7434	2478.0	376.42	125.5	HTSeq--a Python framework to work with high-throughput sequencing data.	Simon Anders, Paul Theodor Pyl, Wolfgang Huber	Bioinformatics	2015	25260700	Yes
486	2476	2476.0	63.77	63.8	Mitochondrial formation of reactive oxygen species.	Julio F Turrens	J Physiol	2003	14561818	No
487	2476	2476.0	90.06	90.1	Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report.	Sarah E Barlow	Pediatrics	2007	18055651	Yes
488	4949	2474.5	110.99	55.5	Emergence of scaling in random networks	Barabasi, Albert	Science	1999	10521342	Yes
489	2472	2472.0	0.0	0.0	Spectroscopic determination of tryptophan and tyrosine in proteins.	H Edelhoch	Biochemistry	1967	6049437	Yes
490	7406	2468.7	216.88	72.3	MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment.	Sudhir Kumar, Koichiro Tamura, Masatoshi Nei	Brief Bioinform	2004	15260895	Yes
491	2468	2468.0	66.88	66.9	Obesity as a medical problem.	P G Kopelman	Nature	2000	10766250	No
492	2467	2467.0	0.0	0.0	Stereotaxic mapping of the monoamine pathways in the rat brain.	U Ungerstedt	Acta Physiol Scand Suppl	1971	4109331	Yes
493	2465	2465.0	75.34	75.3	Optimal two-stage designs for phase II clinical trials.	R Simon	Control Clin Trials	1989	2702835	Yes
494	4925	2462.5	137.86	68.9	Fast and accurate long-read alignment with Burrows-Wheeler transform.	Heng Li, Richard Durbin	Bioinformatics	2010	20080505	Yes
495	2462	2462.0	0.0	0.0	Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.	J D Rowley	Nature	1973	4126434	Yes
496	2453	2453.0	59.29	59.3	Inflammatory bowel disease.	Daniel K Podolsky	N Engl J Med	2002	12167685	No
497	4901	2450.5	166.83	83.4	"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.	A P Feinberg, B Vogelstein	Anal Biochem	1984	6329026	Yes
498	2449	2449.0	53.16	53.2	Toll-like receptors and innate immunity.	R Medzhitov	Nat Rev Immunol	2001	11905821	No
499	2444	2444.0	62.54	62.5	CpG-rich islands and the function of DNA methylation.	A P Bird	Nature	1986	2423876	No
500	2439	2439.0	66.98	67.0	Origin and physiological roles of inflammation.	Ruslan Medzhitov	Nature	2008	18650913	No
501	2438	2438.0	0.0	0.0	Statistical estimations in enzyme kinetics.	G N WILKINSON	Biochem J	1961	13785321	Yes
502	7296	2432.0	206.8	68.9	Understanding the Warburg effect: the metabolic requirements of cell proliferation.	Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson	Science	2009	19460998	No
503	2422	2422.0	66.68	66.7	Chemokines--chemotactic cytokines that mediate inflammation.	A D Luster	N Engl J Med	1998	9459648	No
504	2420	2420.0	103.43	103.4	Inositol trisphosphate and diacylglycerol as second messengers.	M J Berridge	Biochem J	1984	6146314	No
505	9674	2418.5	430.27	107.6	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	BMJ	2009	19622551	No
506	4823	2411.5	0.0	0.0	The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.	R C Graham, M J Karnovsky	J Histochem Cytochem	1966	5962951	Yes
507	2408	2408.0	68.95	69.0	Recent advances with liposomes as pharmaceutical carriers.	Vladimir P Torchilin	Nat Rev Drug Discov	2005	15688077	No
508	4814	2407.0	0.0	0.0	A new method for sequencing DNA.	A M Maxam, W Gilbert	Proc Natl Acad Sci U S A	1977	265521	Yes
509	4813	2406.5	151.18	75.6	TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.	T R Mosmann, R L Coffman	Annu Rev Immunol	1989	2523712	No
510	4812	2406.0	0.0	0.0	Superoxide dismutase: improved assays and an assay applicable to acrylamide gels.	C Beauchamp, I Fridovich	Anal Biochem	1971	4943714	Yes
511	2406	2406.0	93.25	93.2	Psychometric properties of the strengths and difficulties questionnaire.	R Goodman	J Am Acad Child Adolesc Psychiatry	2001	11699809	Yes
512	2403	2403.0	57.86	57.9	TGFbeta in Cancer.	Joan Massagué	Cell	2008	18662538	No
513	2389	2389.0	86.5	86.5	Estimation of metabolite concentrations from localized in vivo proton NMR spectra.	S W Provencher	Magn Reson Med	1993	8139448	Yes
514	2388	2388.0	55.39	55.4	One-step gene disruption in yeast.	R J Rothstein	Methods Enzymol	1983	6310324	Yes
515	7155	2385.0	281.01	93.7	Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases.	R A Deyo, D C Cherkin, M A Ciol	J Clin Epidemiol	1992	1607900	Yes
516	2384	2384.0	108.02	108.0	Half a century of research on the Stroop effect: an integrative review.	C M MacLeod	Psychol Bull	1991	2034749	No
517	2377	2377.0	47.58	47.6	Genome maintenance mechanisms for preventing cancer.	J H Hoeijmakers	Nature	2001	11357144	No
518	4753	2376.5	170.49	85.2	mTOR signaling in growth control and disease.	Mathieu Laplante, David M Sabatini	Cell	2012	22500797	No
519	2375	2375.0	52.37	52.4	Interleukin-12 and the regulation of innate resistance and adaptive immunity.	Giorgio Trinchieri	Nat Rev Immunol	2003	12563297	No
520	4747	2373.5	197.02	98.5	Measuring agreement in method comparison studies.	J M Bland, D G Altman	Stat Methods Med Res	1999	10501650	No
521	4747	2373.5	119.34	59.7	Oxidants, oxidative stress and the biology of ageing.	T Finkel, N J Holbrook	Nature	2000	11089981	No
522	2371	2371.0	124.81	124.8	Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy.	T E Moffitt	Psychol Rev	1993	8255953	No
523	21324	2369.3	604.42	67.2	The Sequence Alignment/Map format and SAMtools.	Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin	Bioinformatics	2009	19505943	Yes
524	4738	2369.0	179.17	89.6	Tissue engineering.	R Langer, J P Vacanti	Science	1993	8493529	No
525	2368	2368.0	56.64	56.6	Nuclear factor-kappaB in cancer development and progression.	Michael Karin	Nature	2006	16724054	No
526	2365	2365.0	0.0	0.0	The magical number seven plus or minus two: some limits on our capacity for processing information.	G A MILLER	Psychol Rev	1956	13310704	Yes
527	2360	2360.0	41.9	41.9	Mechanisms underlying ubiquitination.	C M Pickart	Annu Rev Biochem	2001	11395416	No
528	9439	2359.8	216.55	54.1	Cluster analysis and display of genome-wide expression patterns.	M B Eisen, P T Spellman, P O Brown, D Botstein	Proc Natl Acad Sci U S A	1998	9843981	Yes
529	2358	2358.0	94.95	95.0	Essential oils: their antibacterial properties and potential applications in foods--a review.	Sara Burt	Int J Food Microbiol	2004	15246235	No
530	4713	2356.5	146.06	73.0	The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.	Taro Kawai, Shizuo Akira	Nat Immunol	2010	20404851	No
531	4710	2355.0	178.06	89.0	The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers.	J Vieira, J Messing	Gene	1982	6295879	Yes
532	2351	2351.0	50.1	50.1	Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses.	Shimon Sakaguchi	Annu Rev Immunol	2004	15032588	No
533	2350	2350.0	130.22	130.2	The short-form McGill Pain Questionnaire.	Ronald Melzack	Pain	1987	3670870	Yes
534	2349	2349.0	0.0	0.0	Perceived exertion as an indicator of somatic stress.	G Borg	Scand J Rehabil Med	1970	5523831	Yes
535	4676	2338.0	129.06	64.5	In vitro selection of RNA molecules that bind specific ligands.	A D Ellington, J W Szostak	Nature	1990	1697402	Yes
536	2338	2338.0	0.0	0.0	Estimation of the molecular weights of proteins by Sephadex gel-filtration.	P Andrews	Biochem J	1964	4158310	Yes
537	4666	2333.0	133.79	66.9	Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.	T C Chou, P Talalay	Adv Enzyme Regul	1984	6382953	Yes
538	2331	2331.0	51.82	51.8	Papillomaviruses and cancer: from basic studies to clinical application.	Harald zur Hausen	Nat Rev Cancer	2002	12044010	No
539	13972	2328.7	593.99	99.0	Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support.	Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G Conde	J Biomed Inform	2009	18929686	Yes
540	2326	2326.0	0.0	0.0	The glomerular permeability determined by dextran clearance using Sephadex gel filtration.	C E Mogensen	Scand J Clin Lab Invest	1968	5637478	Yes
541	2326	2326.0	75.32	75.3	Phase separation of integral membrane proteins in Triton X-114 solution.	C Bordier	J Biol Chem	1981	6257680	Yes
542	4648	2324.0	172.31	86.2	The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM.	Stephen B Edge, Carolyn C Compton	Ann Surg Oncol	2010	20180029	No
543	6971	2323.7	221.52	73.8	Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study.	G Evanno, S Regnaut, J Goudet	Mol Ecol	2005	15969739	Yes
544	2323	2323.0	67.63	67.6	Predictive reward signal of dopamine neurons.	W Schultz	J Neurophysiol	1998	9658025	No
545	2321	2321.0	61.31	61.3	Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays.	S A Bustin	J Mol Endocrinol	2000	11013345	No
546	4631	2315.5	176.31	88.2	Computed tomography--an increasing source of radiation exposure.	David J Brenner, Eric J Hall	N Engl J Med	2007	18046031	No
547	6927	2309.0	166.28	55.4	The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.	R C Lee, R L Feinbaum, V Ambros	Cell	1993	8252621	Yes
548	2303	2303.0	94.72	94.7	The processing-speed theory of adult age differences in cognition.	T A Salthouse	Psychol Rev	1996	8759042	No
549	2303	2303.0	49.9	49.9	The danger model: a renewed sense of self.	Polly Matzinger	Science	2002	11951032	Yes
550	4605	2302.5	127.27	63.6	Exploring the full spectrum of macrophage activation.	David M Mosser, Justin P Edwards	Nat Rev Immunol	2008	19029990	No
551	11494	2298.8	527.52	105.5	The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research.	D J Buysse, C F Reynolds, T H Monk, S R Berman, D J Kupfer	Psychiatry Res	1989	2748771	Yes
552	9193	2298.2	458.36	114.6	APACHE II: a severity of disease classification system.	W A Knaus, E A Draper, D P Wagner, J E Zimmerman	Crit Care Med	1985	3928249	Yes
553	4594	2297.0	120.59	60.3	Caspases: enemies within.	N A Thornberry, Y Lazebnik	Science	1998	9721091	No
554	2296	2296.0	60.79	60.8	Molecular chaperones in cellular protein folding.	F U Hartl	Nature	1996	8637592	No
555	2295	2295.0	0.0	0.0	A gene complex controlling segmentation in Drosophila.	E B Lewis	Nature	1978	103000	Yes
556	4586	2293.0	109.13	54.6	Establishment in culture of pluripotential cells from mouse embryos.	M J Evans, M H Kaufman	Nature	1981	7242681	Yes
557	2288	2288.0	52.0	52.0	Getting started with yeast.	F Sherman	Methods Enzymol	1991	2005794	Yes
558	4574	2287.0	100.4	50.2	Innate immune recognition.	Charles A Janeway, Ruslan Medzhitov	Annu Rev Immunol	2002	11861602	No
559	2287	2287.0	62.83	62.8	The resurgence of platinum-based cancer chemotherapy.	Lloyd Kelland	Nat Rev Cancer	2007	17625587	No
560	4569	2284.5	126.09	63.0	Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.	D B Smith, K S Johnson	Gene	1988	3047011	Yes
561	4568	2284.0	0.0	0.0	Assessment of outcome after severe brain damage.	B Jennett, M Bond	Lancet	1975	46957	Yes
562	2283	2283.0	64.71	64.7	The genetic legacy of the Quaternary ice ages.	G Hewitt	Nature	2000	10879524	No
563	2283	2283.0	0.0	0.0	Gene action in the X-chromosome of the mouse (Mus musculus L.).	M F LYON	Nature	1961	13764598	Yes
564	4559	2279.5	153.33	76.7	Complex brain networks: graph theoretical analysis of structural and functional systems.	Ed Bullmore, Olaf Sporns	Nat Rev Neurosci	2009	19190637	No
565	2279	2279.0	104.64	104.6	FreeSurfer.	Bruce Fischl	Neuroimage	2012	22248573	No
566	2276	2276.0	0.0	0.0	Some factors in the interpretation of protein denaturation.	W KAUZMANN	Adv Protein Chem	1959	14404936	Yes
567	9103	2275.8	355.04	88.8	A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu.	Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge Krieg	J Chem Phys	2010	20423165	Yes
568	4544	2272.0	0.0	0.0	A simplified method of evaluating dose-effect experiments.	J T LITCHFIELD, F WILCOXON	J Pharmacol Exp Ther	1949	18152921	Yes
569	4543	2271.5	0.0	0.0	PERIODONTAL DISEASE IN PREGNANCY. II. CORRELATION BETWEEN ORAL HYGIENE AND PERIODONTAL CONDTION.	J SILNESS, H LOE	Acta Odontol Scand	1964	14158464	Yes
570	4528	2264.0	0.0	0.0	Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.	H Aviv, P Leder	Proc Natl Acad Sci U S A	1972	4504350	Yes
571	2264	2264.0	59.26	59.3	Memory--a century of consolidation.	J L McGaugh	Science	2000	10634773	No
572	2262	2262.0	63.58	63.6	Cadherin cell adhesion receptors as a morphogenetic regulator.	M Takeichi	Science	1991	2006419	No
573	2254	2254.0	56.7	56.7	Cell adhesion: the molecular basis of tissue architecture and morphogenesis.	B M Gumbiner	Cell	1996	8608588	No
574	2252	2252.0	0.0	0.0	Analysis of gene diversity in subdivided populations.	M Nei	Proc Natl Acad Sci U S A	1973	4519626	Yes
575	4500	2250.0	159.3	79.7	Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees.	K Tamura, M Nei	Mol Biol Evol	1993	8336541	Yes
576	2245	2245.0	0.0	0.0	On the number of segregating sites in genetical models without recombination.	G A Watterson	Theor Popul Biol	1975	1145509	Yes
577	4487	2243.5	0.0	0.0	Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase.	S Marklund, G Marklund	Eur J Biochem	1974	4215654	Yes
578	2242	2242.0	54.08	54.1	Salt and drought stress signal transduction in plants.	Jian-Kang Zhu	Annu Rev Plant Biol	2002	12221975	No
579	6725	2241.7	234.32	78.1	Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.	Y Gavrieli, Y Sherman, S A Ben-Sasson	J Cell Biol	1992	1400587	Yes
580	2240	2240.0	76.14	76.1	Gene regulation by steroid hormones.	M Beato	Cell	1989	2644044	No
581	6712	2237.3	171.79	57.3	Pathogen recognition and innate immunity.	Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi	Cell	2006	16497588	No
582	8933	2233.2	499.92	125.0	Cancer statistics, 2014.	Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin Jemal	CA Cancer J Clin	2014	24399786	Yes
583	2225	2225.0	43.61	43.6	Wnt signaling and cancer.	P Polakis	Genes Dev	2000	10921899	No
584	4449	2224.5	133.85	66.9	Unified segmentation.	John Ashburner, Karl J Friston	Neuroimage	2005	15955494	Yes
585	2224	2224.0	0.0	0.0	Separation of leukocytes from blood and bone marrow. Introduction.	A Böyum	Scand J Clin Lab Invest Suppl	1968	5707208	Yes
586	8883	2220.8	0.0	0.0	Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.	P W Rigby, M Dieckmann, C Rhodes, P Berg	J Mol Biol	1977	881736	Yes
587	2220	2220.0	70.59	70.6	The transforming growth factor-beta family.	J Massagué	Annu Rev Cell Biol	1990	2177343	No
588	2219	2219.0	57.37	57.4	Prostaglandins and leukotrienes: advances in eicosanoid biology.	C D Funk	Science	2001	11729303	No
589	2218	2218.0	0.0	0.0	Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.	S W Kessler	J Immunol	1975	1102604	Yes
590	2218	2218.0	64.04	64.0	Cell death during development of the nervous system.	R W Oppenheim	Annu Rev Neurosci	1991	2031577	No
591	2207	2207.0	0.0	0.0	Models for the specific adhesion of cells to cells.	G I Bell	Science	1978	347575	No
592	2205	2205.0	64.51	64.5	Cellular and molecular mechanisms of fibrosis.	T A Wynn	J Pathol	2008	18161745	No
593	4407	2203.5	136.32	68.2	Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes.	F W Studier, B A Moffatt	J Mol Biol	1986	3537305	Yes
594	2203	2203.0	0.0	0.0	EQUILIBRIUM ULTRACENTRIFUGATION OF DILUTE SOLUTIONS.	D A YPHANTIS	Biochemistry	1964	14155091	Yes
595	6599	2199.7	288.94	96.3	Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor.	R M Palmer, A G Ferrige, S Moncada	Nature	1987	3495737	Yes
596	2195	2195.0	53.68	53.7	Autophagy: process and function.	Noboru Mizushima	Genes Dev	2007	18006683	No
597	2190	2190.0	78.46	78.5	Primate models of movement disorders of basal ganglia origin.	M R DeLong	Trends Neurosci	1990	1695404	No
598	17513	2189.1	425.05	53.1	The Protein Data Bank.	H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E Bourne	Nucleic Acids Res	2000	10592235	Yes
599	4378	2189.0	196.73	98.4	Longitudinal data analysis for discrete and continuous outcomes.	S L Zeger, K Y Liang	Biometrics	1986	3719049	Yes
600	4378	2189.0	95.22	47.6	MicroRNAs: small RNAs with a big role in gene regulation.	Lin He, Gregory J Hannon	Nat Rev Genet	2004	15211354	No
601	4377	2188.5	192.6	96.3	A method of comparing the areas under receiver operating characteristic curves derived from the same cases.	J A Hanley, B J McNeil	Radiology	1983	6878708	Yes
602	4375	2187.5	236.1	118.0	GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update.	Rod Peakall, Peter E Smouse	Bioinformatics	2012	22820204	Yes
603	2187	2187.0	69.52	69.5	RELION: implementation of a Bayesian approach to cryo-EM structure determination.	Sjors H W Scheres	J Struct Biol	2012	23000701	Yes
604	4373	2186.5	144.1	72.0	Adherence to medication.	Lars Osterberg, Terrence Blaschke	N Engl J Med	2005	16079372	No
605	2186	2186.0	0.0	0.0	A relation between non-esterified fatty acids in plasma and the metabolism of glucose.	V P DOLE	J Clin Invest	1956	13286333	Yes
606	2182	2182.0	0.0	0.0	Pharmacological implications of microsomal enzyme induction.	A H Conney	Pharmacol Rev	1967	4383307	Yes
607	4364	2182.0	0.0	0.0	Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain.	J Glowinski, L L Iversen	J Neurochem	1966	5950056	Yes
608	2182	2182.0	0.0	0.0	[Rapid physiological coagulation method in determination of fibrinogen].	A CLAUSS	Acta Haematol	1957	13434757	Yes
609	4355	2177.5	114.73	57.4	High-efficiency transformation of mammalian cells by plasmid DNA.	C Chen, H Okayama	Mol Cell Biol	1987	3670292	Yes
610	2177	2177.0	81.52	81.5	Delayed neuronal death in the gerbil hippocampus following ischemia.	T Kirino	Brain Res	1982	7093691	Yes
611	6531	2177.0	281.18	93.7	Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups.	Allison Tong, Peter Sainsbury, Jonathan Craig	Int J Qual Health Care	2007	17872937	Yes
612	2175	2175.0	50.45	50.5	Principles of CDK regulation.	D O Morgan	Nature	1995	7877684	No
613	8697	2174.2	316.98	79.2	Establishing a standard definition for child overweight and obesity worldwide: international survey.	T J Cole, M C Bellizzi, K M Flegal, W H Dietz	BMJ	2000	10797032	Yes
614	4342	2171.0	0.0	0.0	Electrochemical photolysis of water at a semiconductor electrode.	A Fujishima, K Honda	Nature	1972	12635268	Yes
615	2168	2168.0	53.98	54.0	Epigenetics in cancer.	Manel Esteller	N Engl J Med	2008	18337604	No
616	2165	2165.0	52.85	52.9	Bone resorption by osteoclasts.	S L Teitelbaum	Science	2000	10968780	No
617	4325	2162.5	0.0	0.0	Pain mechanisms: a new theory.	R Melzack, P D Wall	Science	1965	5320816	No
618	2162	2162.0	96.2	96.2	Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM.	Joseph P Weir	J Strength Cond Res	2005	15705040	No
619	2159	2159.0	0.0	0.0	Measurement of pain.	E C Huskisson	Lancet	1974	4139420	Yes
620	4314	2157.0	112.23	56.1	Autophagy in the pathogenesis of disease.	Beth Levine, Guido Kroemer	Cell	2008	18191218	No
621	4313	2156.5	100.27	50.1	Inflammation and cancer: back to Virchow?	F Balkwill, A Mantovani	Lancet	2001	11229684	No
622	2155	2155.0	0.0	0.0	Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism.	P MITCHELL	Nature	1961	13771349	Yes
623	2146	2146.0	59.46	59.5	Structure and function of telomeres.	E H Blackburn	Nature	1991	1708110	No
624	2142	2142.0	73.53	73.5	Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century.	M Leavitt	MedGenMed	2001	11549951	No
625	6421	2140.3	128.16	42.7	Gene Expression Omnibus: NCBI gene expression and hybridization array data repository.	Ron Edgar, Michael Domrachev, Alex E Lash	Nucleic Acids Res	2002	11752295	Yes
626	4274	2137.0	0.0	0.0	PERIODONTAL DISEASE IN PREGNANCY. I. PREVALENCE AND SEVERITY.	H LOE, J SILNESS	Acta Odontol Scand	1963	14121956	Yes
627	4262	2131.0	262.5	131.2	Revised methods for the Salmonella mutagenicity test.	D M Maron, B N Ames	Mutat Res	1983	6341825	Yes
628	4247	2123.5	116.51	58.3	Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis.	D Hanahan, J Folkman	Cell	1996	8756718	No
629	4245	2122.5	0.0	0.0	The fluid mosaic model of the structure of cell membranes.	S J Singer, G L Nicolson	Science	1972	4333397	Yes
630	2121	2121.0	74.83	74.8	Implications of normal brain development for the pathogenesis of schizophrenia.	D R Weinberger	Arch Gen Psychiatry	1987	3606332	Yes
631	2120	2120.0	0.0	0.0	A protein binding assay for adenosine 3':5'-cyclic monophosphate.	A G Gilman	Proc Natl Acad Sci U S A	1970	4318781	Yes
632	4229	2114.5	156.51	78.3	Complex network measures of brain connectivity: uses and interpretations.	Mikail Rubinov, Olaf Sporns	Neuroimage	2010	19819337	Yes
633	2114	2114.0	55.08	55.1	MapChart: software for the graphical presentation of linkage maps and QTLs.	R E Voorrips	J Hered	2002	12011185	Yes
634	2113	2113.0	98.19	98.2	You want to measure coping but your protocol's too long: consider the brief COPE.	C S Carver	Int J Behav Med	1997	16250744	Yes
635	6337	2112.3	193.67	64.6	Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.	C M Gorman, L F Moffat, B H Howard	Mol Cell Biol	1982	6960240	Yes
636	2109	2109.0	0.0	0.0	Intracellular aspects of the process of protein synthesis.	G Palade	Science	1975	1096303	No
637	2103	2103.0	55.06	55.1	Vascular endothelial growth factor: basic science and clinical progress.	Napoleone Ferrara	Endocr Rev	2004	15294883	No
638	2103	2103.0	57.88	57.9	Cancer nanotechnology: opportunities and challenges.	Mauro Ferrari	Nat Rev Cancer	2005	15738981	No
639	2103	2103.0	85.59	85.6	What is value in health care?	Michael E Porter	N Engl J Med	2010	21142528	Yes
640	2102	2102.0	97.67	97.7	Measures of reliability in sports medicine and science.	W G Hopkins	Sports Med	2000	10907753	Yes
641	2098	2098.0	0.0	0.0	Colorimetric assay of catalase.	A K Sinha	Anal Biochem	1972	4556490	Yes
642	2098	2098.0	53.27	53.3	Calcium signaling.	David E Clapham	Cell	2007	18083096	No
643	4193	2096.5	111.73	55.9	Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences.	Weizhong Li, Adam Godzik	Bioinformatics	2006	16731699	Yes
644	4178	2089.0	209.77	104.9	The qualitative content analysis process.	Satu Elo, Helvi Kyngäs	J Adv Nurs	2008	18352969	Yes
645	2088	2088.0	72.28	72.3	Accelerated Profile HMM Searches.	Sean R Eddy	PLoS Comput Biol	2011	22039361	Yes
646	2086	2086.0	0.0	0.0	The genetical structure of populations.	S WRIGHT	Ann Eugen	1951	24540312	Yes
647	2078	2078.0	50.76	50.8	Angiogenesis in life, disease and medicine.	Peter Carmeliet	Nature	2005	16355210	No
648	2076	2076.0	39.8	39.8	Java Treeview--extensible visualization of microarray data.	Alok J Saldanha	Bioinformatics	2004	15180930	Yes
649	4148	2074.0	88.78	44.4	Untangling the ErbB signalling network.	Y Yarden, M X Sliwkowski	Nat Rev Mol Cell Biol	2001	11252954	No
650	2073	2073.0	55.4	55.4	Causes and consequences of microRNA dysregulation in cancer.	Carlo M Croce	Nat Rev Genet	2009	19763153	No
651	12421	2070.2	314.59	52.4	Phaser crystallographic software.	Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J Read	J Appl Crystallogr	2007	19461840	Yes
652	2068	2068.0	80.24	80.2	Inositol trisphosphate and diacylglycerol: two interacting second messengers.	M J Berridge	Annu Rev Biochem	1987	3304132	No
653	2068	2068.0	65.85	65.8	The nerve growth factor 35 years later.	R Levi-Montalcini	Science	1987	3306916	No
654	4129	2064.5	0.0	0.0	Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent.	J Sedlak, R H Lindsay	Anal Biochem	1968	4973948	Yes
655	2058	2058.0	0.0	0.0	Satellite cell of skeletal muscle fibers.	A MAURO	J Biophys Biochem Cytol	1961	13768451	Yes
656	6168	2056.0	0.0	0.0	Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane.	G Fairbanks, T L Steck, D F Wallach	Biochemistry	1971	4326772	Yes
657	2056	2056.0	68.71	68.7	adegenet: a R package for the multivariate analysis of genetic markers.	Thibaut Jombart	Bioinformatics	2008	18397895	Yes
658	2052	2052.0	49.18	49.2	Molecular physiology of P2X receptors.	R Alan North	Physiol Rev	2002	12270951	No
659	2051	2051.0	47.5	47.5	Evolving concepts of rheumatoid arthritis.	Gary S Firestein	Nature	2003	12748655	No
660	2051	2051.0	43.7	43.7	Tumour-educated macrophages promote tumour progression and metastasis.	Jeffrey W Pollard	Nat Rev Cancer	2004	14708027	No
661	2047	2047.0	0.0	0.0	Elastic properties of lipid bilayers: theory and possible experiments.	W Helfrich	Z Naturforsch C	1973	4273690	Yes
662	4092	2046.0	86.07	43.0	CDK inhibitors: positive and negative regulators of G1-phase progression.	C J Sherr, J M Roberts	Genes Dev	1999	10385618	No
663	2043	2043.0	90.21	90.2	The Danish Civil Registration System.	Carsten Bøcker Pedersen	Scand J Public Health	2011	21775345	Yes
664	4085	2042.5	158.99	79.5	The neural basis of drug craving: an incentive-sensitization theory of addiction.	T E Robinson, K C Berridge	Brain Res Brain Res Rev	1993	8401595	No
665	2036	2036.0	106.95	107.0	Qualitative research. Introducing focus groups.	J Kitzinger	BMJ	1995	7633241	Yes
666	6093	2031.0	426.29	142.1	Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition.	P J Van Soest, J B Robertson, B A Lewis	J Dairy Sci	1991	1660498	No
667	4061	2030.5	85.5	42.8	Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.	D Bonnet, J E Dick	Nat Med	1997	9212098	Yes
668	4057	2028.5	88.98	44.5	Lipid rafts and signal transduction.	K Simons, D Toomre	Nat Rev Mol Cell Biol	2000	11413487	No
669	6083	2027.7	0.0	0.0	Immunochemical quantitation of antigens by single radial immunodiffusion.	G Mancini, A O Carbonara, J F Heremans	Immunochemistry	1965	4956917	Yes
670	4052	2026.0	161.21	80.6	Glutathione.	A Meister, M E Anderson	Annu Rev Biochem	1983	6137189	No
671	4047	2023.5	0.0	0.0	The serial cultivation of human diploid cell strains.	L HAYFLICK, P S MOORHEAD	Exp Cell Res	1961	13905658	Yes
672	2021	2021.0	55.98	56.0	Molecular basis of bacterial outer membrane permeability revisited.	Hiroshi Nikaido	Microbiol Mol Biol Rev	2003	14665678	No
673	8072	2018.0	251.0	62.8	GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation.	Berk Hess, Carsten Kutzner, David van der Spoel, Erik Lindahl	J Chem Theory Comput	2008	26620784	Yes
674	2017	2017.0	58.09	58.1	Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface.	G P Smith	Science	1985	4001944	Yes
675	2017	2017.0	0.0	0.0	A study of fixation for electron microscopy.	G E PALADE	J Exp Med	1952	14927794	Yes
676	4033	2016.5	146.52	73.3	Rapid isolation of high molecular weight plant DNA.	M G Murray, W F Thompson	Nucleic Acids Res	1980	7433111	Yes
677	2016	2016.0	76.47	76.5	SF-36 health survey update.	J E Ware	Spine (Phila Pa 1976)	2000	11124729	No
678	2014	2014.0	72.01	72.0	What are the functional consequences of neurocognitive deficits in schizophrenia?	M F Green	Am J Psychiatry	1996	8610818	No
679	2013	2013.0	60.21	60.2	The magical number 4 in short-term memory: a reconsideration of mental storage capacity.	N Cowan	Behav Brain Sci	2001	11515286	Yes
680	2008	2008.0	0.0	0.0	Transduction of linked genetic characters of the host by bacteriophage P1.	E S LENNOX	Virology	1955	13267987	Yes
681	8029	2007.2	274.04	68.5	Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy.	Qiong Wang, George M Garrity, James M Tiedje, James R Cole	Appl Environ Microbiol	2007	17586664	Yes
682	2004	2004.0	44.87	44.9	Telomere measurement by quantitative PCR.	Richard M Cawthon	Nucleic Acids Res	2002	12000852	Yes
683	4002	2001.0	119.04	59.5	Management of hepatocellular carcinoma.	Jordi Bruix, Morris Sherman	Hepatology	2005	16250051	No
684	1994	1994.0	48.24	48.2	A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine.	Douglas C Wallace	Annu Rev Genet	2005	16285865	No
685	3988	1994.0	98.41	49.2	Signal integration in the endoplasmic reticulum unfolded protein response.	David Ron, Peter Walter	Nat Rev Mol Cell Biol	2007	17565364	No
686	3984	1992.0	83.81	41.9	The phosphatidylinositol 3-Kinase AKT pathway in human cancer.	Igor Vivanco, Charles L Sawyers	Nat Rev Cancer	2002	12094235	No
687	3984	1992.0	120.54	60.3	Pattern recognition receptors and inflammation.	Osamu Takeuchi, Shizuo Akira	Cell	2010	20303872	No
688	1990	1990.0	58.92	58.9	Dietary pattern analysis: a new direction in nutritional epidemiology.	Frank B Hu	Curr Opin Lipidol	2002	11790957	No
689	5970	1990.0	0.0	0.0	THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.	F C GREENWOOD, W M HUNTER, J S GLOVER	Biochem J	1963	14097352	Yes
690	1990	1990.0	84.32	84.3	A computational approach to edge detection.	J Canny	IEEE Trans Pattern Anal Mach Intell	1986	21869365	Yes
691	1986	1986.0	65.33	65.3	The anatomy and taxonomy of protein structure.	J S Richardson	Adv Protein Chem	1981	7020376	No
692	1981	1981.0	81.34	81.3	Matrix metalloproteinases and their inhibitors in connective tissue remodeling.	J F Woessner	FASEB J	1991	1850705	No
693	3960	1980.0	149.01	74.5	Inositol trisphosphate, a novel second messenger in cellular signal transduction.	M J Berridge, R F Irvine	Nature	1984	6095092	No
694	3958	1979.0	151.67	75.8	Accurate and simple analytic representation of the electron-gas correlation energy.	Perdew, Wang	Phys Rev B Condens Matter	1992	10001404	Yes
695	1978	1978.0	65.73	65.7	Two-sided confidence intervals for the single proportion: comparison of seven methods.	R G Newcombe	Stat Med	1998	9595616	Yes
696	1977	1977.0	0.0	0.0	A rapid radiochemical method for the determination of choline acetyltransferase.	F Fonnum	J Neurochem	1975	1113118	Yes
697	1971	1971.0	0.0	0.0	The gel-filtration behaviour of proteins related to their molecular weights over a wide range.	P Andrews	Biochem J	1965	5862401	Yes
698	1968	1968.0	52.87	52.9	A mechanism for cognitive dynamics: neuronal communication through neuronal coherence.	Pascal Fries	Trends Cogn Sci	2005	16150631	No
699	5892	1964.0	0.0	0.0	The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum.	R J HAVEL, H A EDER, J H BRAGDON	J Clin Invest	1955	13252080	Yes
700	3912	1956.0	108.74	54.4	Reactive oxygen species: metabolism, oxidative stress, and signal transduction.	Klaus Apel, Heribert Hirt	Annu Rev Plant Biol	2004	15377225	No
701	1956	1956.0	76.25	76.2	Ethical authorship and publishing.	Andrew J S Coats	Int J Cardiol	2009	19046787	No
702	1955	1955.0	41.95	42.0	The molecular biology of memory storage: a dialogue between genes and synapses.	E R Kandel	Science	2001	11691980	No
703	1955	1955.0	49.67	49.7	Modularity and community structure in networks.	M E J Newman	Proc Natl Acad Sci U S A	2006	16723398	Yes
704	3909	1954.5	0.0	0.0	A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.	S REITMAN, S FRANKEL	Am J Clin Pathol	1957	13458125	Yes
705	1952	1952.0	78.37	78.4	Working memory.	A Baddeley	Science	1992	1736359	No
706	3903	1951.5	82.6	41.3	Mechanisms of TGF-beta signaling from cell membrane to the nucleus.	Yigong Shi, Joan Massagué	Cell	2003	12809600	No
707	5854	1951.3	195.13	65.0	Bacterial biofilms: a common cause of persistent infections.	J W Costerton, P S Stewart, E P Greenberg	Science	1999	10334980	No
708	1951	1951.0	67.44	67.4	Scaffolds in tissue engineering bone and cartilage.	D W Hutmacher	Biomaterials	2000	11071603	Yes
709	1951	1951.0	56.42	56.4	Immunological and inflammatory functions of the interleukin-1 family.	Charles A Dinarello	Annu Rev Immunol	2009	19302047	No
710	1949	1949.0	45.73	45.7	NOX enzymes and the biology of reactive oxygen.	J David Lambeth	Nat Rev Immunol	2004	15039755	No
711	3898	1949.0	154.69	77.3	FLASH: fast length adjustment of short reads to improve genome assemblies.	Tanja Magoč, Steven L Salzberg	Bioinformatics	2011	21903629	Yes
712	5846	1948.7	165.39	55.1	RNA-Seq: a revolutionary tool for transcriptomics.	Zhong Wang, Mark Gerstein, Michael Snyder	Nat Rev Genet	2009	19015660	No
713	3891	1945.5	157.93	79.0	The L-arginine-nitric oxide pathway.	S Moncada, A Higgs	N Engl J Med	1993	7504210	No
714	1942	1942.0	53.4	53.4	Ischemic cell death in brain neurons.	P Lipton	Physiol Rev	1999	10508238	No
715	3881	1940.5	90.61	45.3	New functions for the matrix metalloproteinases in cancer progression.	Mikala Egeblad, Zena Werb	Nat Rev Cancer	2002	11990853	No
716	1939	1939.0	0.0	0.0	Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method.	L SVENNERHOLM	Biochim Biophys Acta	1957	13436486	Yes
717	1938	1938.0	38.17	38.2	Targeting RAS signalling pathways in cancer therapy.	Julian Downward	Nat Rev Cancer	2003	12509763	No
718	3874	1937.0	161.83	80.9	The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions.	S H Downs, N Black	J Epidemiol Community Health	1998	9764259	Yes
719	3872	1936.0	0.0	0.0	A general method applicable to the search for similarities in the amino acid sequence of two proteins.	S B Needleman, C D Wunsch	J Mol Biol	1970	5420325	Yes
720	1934	1934.0	62.55	62.5	Physiology and neurobiology of stress and adaptation: central role of the brain.	Bruce S McEwen	Physiol Rev	2007	17615391	No
721	3864	1932.0	0.0	0.0	Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.	L A Greene, A S Tischler	Proc Natl Acad Sci U S A	1976	1065897	Yes
722	1931	1931.0	63.8	63.8	Dominant forces in protein folding.	K A Dill	Biochemistry	1990	2207096	No
723	3857	1928.5	87.9	44.0	A novel genetic system to detect protein-protein interactions.	S Fields, O Song	Nature	1989	2547163	Yes
724	3857	1928.5	115.94	58.0	Calculation of protein extinction coefficients from amino acid sequence data.	S C Gill, P H von Hippel	Anal Biochem	1989	2610349	Yes
725	5780	1926.7	144.08	48.0	The biology of VEGF and its receptors.	Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter	Nat Med	2003	12778165	No
726	3853	1926.5	180.84	90.4	A feature-integration theory of attention.	A M Treisman, G Gelade	Cogn Psychol	1980	7351125	Yes
727	3834	1917.0	95.31	47.7	Death receptors: signaling and modulation.	A Ashkenazi, V M Dixit	Science	1998	9721089	No
728	1914	1914.0	47.01	47.0	Mitochondrial diseases in man and mouse.	D C Wallace	Science	1999	10066162	No
729	3824	1912.0	107.06	53.5	A global optimisation method for robust affine registration of brain images.	M Jenkinson, S Smith	Med Image Anal	2001	11516708	Yes
730	1910	1910.0	47.86	47.9	G1 phase progression: cycling on cue.	C J Sherr	Cell	1994	7954821	No
731	3809	1904.5	93.39	46.7	AKT/PKB signaling: navigating downstream.	Brendan D Manning, Lewis C Cantley	Cell	2007	17604717	No
732	3806	1903.0	0.0	0.0	A modified uronic acid carbazole reaction.	T BITTER, H M MUIR	Anal Biochem	1962	13971270	Yes
733	1899	1899.0	0.0	0.0	A RAPID PERMETHYLATION OF GLYCOLIPID, AND POLYSACCHARIDE CATALYZED BY METHYLSULFINYL CARBANION IN DIMETHYL SULFOXIDE.	S HAKOMORI	J Biochem	1964	14135466	Yes
734	1895	1895.0	57.96	58.0	Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity.	E C Butcher	Cell	1991	1760836	No
735	1895	1895.0	68.01	68.0	Biodiesel from microalgae.	Yusuf Chisti	Biotechnol Adv	2007	17350212	No
736	1893	1893.0	70.36	70.4	A two process model of sleep regulation.	A A Borbély	Hum Neurobiol	1982	7185792	Yes
737	3785	1892.5	100.95	50.5	Protein misfolding, functional amyloid, and human disease.	Fabrizio Chiti, Christopher M Dobson	Annu Rev Biochem	2006	16756495	No
738	5674	1891.3	298.96	99.7	Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale.	J L Cox, J M Holden, R Sagovsky	Br J Psychiatry	1987	3651732	Yes
739	1891	1891.0	44.93	44.9	Universal control mechanism regulating onset of M-phase.	P Nurse	Nature	1990	2138713	No
740	3775	1887.5	125.52	62.8	Neural mechanisms of selective visual attention.	R Desimone, J Duncan	Annu Rev Neurosci	1995	7605061	No
741	1887	1887.0	96.69	96.7	Effective physician-patient communication and health outcomes: a review.	M A Stewart	CMAJ	1995	7728691	Yes
742	1885	1885.0	0.0	0.0	On estimating the relation between blood group and disease.	B WOOLF	Ann Hum Genet	1955	14388528	Yes
743	1883	1883.0	57.23	57.2	A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data.	Heng Li	Bioinformatics	2011	21903627	Yes
744	3747	1873.5	126.7	63.4	Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9167458	Yes
745	1873	1873.0	46.76	46.8	Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling.	T Hunter	Cell	1995	7834742	No
746	3744	1872.0	115.73	57.9	Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging.	Michael D Fox, Marcus E Raichle	Nat Rev Neurosci	2007	17704812	No
747	3741	1870.5	103.32	51.7	Nonparametric permutation tests for functional neuroimaging: a primer with examples.	Thomas E Nichols, Andrew P Holmes	Hum Brain Mapp	2002	11747097	Yes
748	1869	1869.0	109.08	109.1	Interrater reliability: the kappa statistic.	Mary L McHugh	Biochem Med (Zagreb)	2012	23092060	Yes
749	1864	1864.0	52.77	52.8	Biology of natural killer cells.	G Trinchieri	Adv Immunol	1989	2683611	No
750	3726	1863.0	106.44	53.2	The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.	Karen Bedard, Karl-Heinz Krause	Physiol Rev	2007	17237347	No
751	3716	1858.0	173.7	86.8	Self-rated health and mortality: a review of twenty-seven community studies.	E L Idler, Y Benyamini	J Health Soc Behav	1997	9097506	No
752	3712	1856.0	99.5	49.8	Myeloid-derived suppressor cells as regulators of the immune system.	Dmitry I Gabrilovich, Srinivas Nagaraj	Nat Rev Immunol	2009	19197294	No
753	1855	1855.0	46.34	46.3	Rab GTPases as coordinators of vesicle traffic.	Harald Stenmark	Nat Rev Mol Cell Biol	2009	19603039	No
754	1853	1853.0	63.59	63.6	Japanese Classification of Gastric Carcinoma - 2nd English Edition -	Japanese Gastric Cancer Association	Gastric Cancer	1998	11957040	Yes
755	1852	1852.0	71.8	71.8	DNA methylation age of human tissues and cell types.	Steve Horvath	Genome Biol	2013	24138928	Yes
756	3703	1851.5	0.0	0.0	Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid.	J D WATSON, F H CRICK	Nature	1953	13054692	Yes
757	1851	1851.0	38.02	38.0	NK cell recognition.	Lewis L Lanier	Annu Rev Immunol	2005	15771571	No
758	1848	1848.0	36.89	36.9	Histone acetylation in chromatin structure and transcription.	M Grunstein	Nature	1997	9311776	No
759	3691	1845.5	0.0	0.0	Screening lambdagt recombinant clones by hybridization to single plaques in situ.	W D Benton, R W Davis	Science	1977	322279	Yes
760	1844	1844.0	0.0	0.0	The information capacity of the human motor system in controlling the amplitude of movement.	P M FITTS	J Exp Psychol	1954	13174710	Yes
761	1843	1843.0	0.0	0.0	A simple technique for demonstrating centromeric heterochromatin.	A T Sumner	Exp Cell Res	1972	4117921	Yes
762	5525	1841.7	152.84	50.9	ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data.	Kai Wang, Mingyao Li, Hakon Hakonarson	Nucleic Acids Res	2010	20601685	Yes
763	1841	1841.0	0.0	0.0	The biology of oxygen radicals.	I Fridovich	Science	1978	210504	Yes
764	1841	1841.0	41.1	41.1	Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self.	Shimon Sakaguchi	Nat Immunol	2005	15785760	No
765	1840	1840.0	42.67	42.7	Cisplatin: mode of cytotoxic action and molecular basis of resistance.	Zahid H Siddik	Oncogene	2003	14576837	No
766	1840	1840.0	58.16	58.2	Efficient methods to compute genomic predictions.	P M VanRaden	J Dairy Sci	2008	18946147	Yes
767	5519	1839.7	339.03	113.0	Deep learning.	Yann LeCun, Yoshua Bengio, Geoffrey Hinton	Nature	2015	26017442	No
768	1839	1839.0	45.2	45.2	Complement. First of two parts.	M J Walport	N Engl J Med	2001	11287977	No
769	1839	1839.0	114.52	114.5	Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs.	Daniël Lakens	Front Psychol	2013	24324449	No
770	1838	1838.0	46.46	46.5	Chemokines and leukocyte traffic.	M Baggiolini	Nature	1998	9560152	No
771	1837	1837.0	49.08	49.1	Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens.	Jane Glazebrook	Annu Rev Phytopathol	2005	16078883	No
772	1836	1836.0	78.35	78.3	Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.	B Samuelsson	Science	1983	6301011	Yes
773	3670	1835.0	86.88	43.4	Mass spectrometry-based proteomics.	Ruedi Aebersold, Matthias Mann	Nature	2003	12634793	No
774	1834	1834.0	63.04	63.0	Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention.	P Correa	Cancer Res	1992	1458460	No
775	1833	1833.0	72.73	72.7	Reactive oxygen species and the central nervous system.	B Halliwell	J Neurochem	1992	1402908	No
776	1831	1831.0	0.0	0.0	Isolation by Distance.	S Wright	Genetics	1943	17247074	Yes
777	5486	1828.7	178.88	59.6	Quantum mechanical continuum solvation models.	Jacopo Tomasi, Benedetta Mennucci, Roberto Cammi	Chem Rev	2005	16092826	Yes
778	1828	1828.0	62.96	63.0	Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples.	Peter C Austin	Stat Med	2009	19757444	Yes
779	1823	1823.0	60.61	60.6	Parkinson's disease: clinical features and diagnosis.	J Jankovic	J Neurol Neurosurg Psychiatry	2008	18344392	No
780	3644	1822.0	0.0	0.0	The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase.	H P Misra, I Fridovich	J Biol Chem	1972	4623845	Yes
781	1822	1822.0	36.91	36.9	Shelterin: the protein complex that shapes and safeguards human telomeres.	Titia de Lange	Genes Dev	2005	16166375	No
782	3644	1822.0	192.64	96.3	phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data.	Paul J McMurdie, Susan Holmes	PLoS One	2013	23630581	Yes
783	3641	1820.5	104.78	52.4	UniFrac: a new phylogenetic method for comparing microbial communities.	Catherine Lozupone, Rob Knight	Appl Environ Microbiol	2005	16332807	Yes
784	1820	1820.0	85.73	85.7	Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals.	H W Steinbusch	Neuroscience	1981	7017455	Yes
785	3638	1819.0	152.99	76.5	Random-effects models for longitudinal data.	N M Laird, J H Ware	Biometrics	1982	7168798	Yes
786	3635	1817.5	113.32	56.7	Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up.	C W Elston, I O Ellis	Histopathology	1991	1757079	Yes
787	1817	1817.0	49.26	49.3	SV40-transformed simian cells support the replication of early SV40 mutants.	Y Gluzman	Cell	1981	6260373	Yes
788	1815	1815.0	60.18	60.2	Hybrid porous solids: past, present, future.	Gérard Férey	Chem Soc Rev	2008	18197340	Yes
789	1813	1813.0	57.87	57.9	The episodic buffer: a new component of working memory?	Baddeley	Trends Cogn Sci	2000	11058819	Yes
790	1812	1812.0	62.2	62.2	Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose.	J Kyhse-Andersen	J Biochem Biophys Methods	1984	6530509	Yes
791	1812	1812.0	55.86	55.9	Pancreatic cancer.	Manuel Hidalgo	N Engl J Med	2010	20427809	No
792	1811	1811.0	43.37	43.4	Nitric oxide and the immune response.	C Bogdan	Nat Immunol	2001	11577346	No
793	1807	1807.0	60.31	60.3	Stress, adaptation, and disease. Allostasis and allostatic load.	B S McEwen	Ann N Y Acad Sci	1998	9629234	No
794	3613	1806.5	106.07	53.0	Acute-phase proteins and other systemic responses to inflammation.	C Gabay, I Kushner	N Engl J Med	1999	9971870	No
795	1802	1802.0	88.75	88.8	Central sensitization: implications for the diagnosis and treatment of pain.	Clifford J Woolf	Pain	2011	20961685	No
796	1801	1801.0	54.81	54.8	A model for receptor-regulated calcium entry.	J W Putney	Cell Calcium	1986	2420465	No
797	1800	1800.0	49.19	49.2	Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences.	Edward V Loftus	Gastroenterology	2004	15168363	Yes
798	1798	1798.0	68.85	68.8	An empirical correction for absorption anisotropy.	R H Blessing	Acta Crystallogr A	1995	7702794	Yes
799	1797	1797.0	74.41	74.4	Role of oxidative stress in development of complications in diabetes.	J W Baynes	Diabetes	1991	2010041	No
800	3593	1796.5	88.89	44.4	Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.	F Sallusto, A Lanzavecchia	J Exp Med	1994	8145033	Yes
801	3592	1796.0	93.48	46.7	The Bcl-2 protein family: arbiters of cell survival.	J M Adams, S Cory	Science	1998	9735050	No
802	5388	1796.0	110.83	36.9	Control of regulatory T cell development by the transcription factor Foxp3.	Shohei Hori, Takashi Nomura, Shimon Sakaguchi	Science	2003	12522256	Yes
803	1795	1795.0	63.95	64.0	Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication.	H G Gratzner	Science	1982	7123245	Yes
804	3588	1794.0	101.2	50.6	Signal transduction by receptors with tyrosine kinase activity.	A Ullrich, J Schlessinger	Cell	1990	2158859	No
805	1794	1794.0	45.73	45.7	The regulation of AP-1 activity by mitogen-activated protein kinases.	M Karin	J Biol Chem	1995	7622446	No
806	1793	1793.0	64.06	64.1	The unfolded protein response: controlling cell fate decisions under ER stress and beyond.	Claudio Hetz	Nat Rev Mol Cell Biol	2012	22251901	No
807	3585	1792.5	0.0	0.0	The interpretation of protein structures: estimation of static accessibility.	B Lee, F M Richards	J Mol Biol	1971	5551392	Yes
808	5377	1792.3	154.09	51.4	Cortical surface-based analysis. I. Segmentation and surface reconstruction.	A M Dale, B Fischl, M I Sereno	Neuroimage	1999	9931268	Yes
809	1792	1792.0	54.87	54.9	Descending control of pain.	Mark J Millan	Prog Neurobiol	2002	12034378	No
810	1791	1791.0	0.0	0.0	A RATIONALE AND TEST FOR THE NUMBER OF FACTORS IN FACTOR ANALYSIS.	J L HORN	Psychometrika	1965	14306381	Yes
811	3575	1787.5	108.34	54.2	Application of phylogenetic networks in evolutionary studies.	Daniel H Huson, David Bryant	Mol Biol Evol	2006	16221896	Yes
812	3572	1786.0	178.17	89.1	A simple, rapid, and sensitive DNA assay procedure.	C Labarca, K Paigen	Anal Biochem	1980	6158890	Yes
813	1786	1786.0	71.39	71.4	Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men.	W A Craig	Clin Infect Dis	1998	9455502	No
814	1784	1784.0	58.44	58.4	A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.	P Chomczynski	Biotechniques	1993	7692896	Yes
815	1784	1784.0	49.72	49.7	RGD and other recognition sequences for integrins.	E Ruoslahti	Annu Rev Cell Dev Biol	1996	8970741	No
816	3567	1783.5	0.0	0.0	Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.	T V Bliss, T Lomo	J Physiol	1973	4727084	Yes
817	10697	1782.8	404.4	67.4	Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.	Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell Parkin	Int J Cancer	2010	21351269	Yes
818	7123	1780.8	171.32	42.8	Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.	A Krogh, B Larsson, G von Heijne, E L Sonnhammer	J Mol Biol	2001	11152613	Yes
819	1779	1779.0	80.23	80.2	Glutamate, nitric oxide and cell-cell signalling in the nervous system.	J Garthwaite	Trends Neurosci	1991	1708538	No
820	1778	1778.0	48.23	48.2	Inferring the historical patterns of biological evolution.	M Pagel	Nature	1999	10553904	Yes
821	1775	1775.0	47.5	47.5	The inflammatory reflex.	Kevin J Tracey	Nature	2002	12490958	No
822	5321	1773.7	164.71	54.9	Immunity, inflammation, and cancer.	Sergei I Grivennikov, Florian R Greten, Michael Karin	Cell	2010	20303878	No
823	1773	1773.0	72.33	72.3	Spinal and supraspinal factors in human muscle fatigue.	S C Gandevia	Physiol Rev	2001	11581501	No
824	3544	1772.0	131.74	65.9	Missing data: our view of the state of the art.	Joseph L Schafer, John W Graham	Psychol Methods	2002	12090408	Yes
825	3543	1771.5	198.56	99.3	Clinical significance: a statistical approach to defining meaningful change in psychotherapy research.	N S Jacobson, P Truax	J Consult Clin Psychol	1991	2002127	Yes
826	1771	1771.0	50.07	50.1	T cell exhaustion.	E John Wherry	Nat Immunol	2011	21739672	No
827	3541	1770.5	395.3	197.7	A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research.	Terry K Koo, Mae Y Li	J Chiropr Med	2016	27330520	Yes
828	3540	1770.0	104.19	52.1	Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results.	E Lander, L Kruglyak	Nat Genet	1995	7581446	Yes
829	1768	1768.0	52.18	52.2	Working memory: looking back and looking forward.	Alan Baddeley	Nat Rev Neurosci	2003	14523382	No
830	1767	1767.0	48.14	48.1	Specification of cerebral cortical areas.	P Rakic	Science	1988	3291116	No
831	1767	1767.0	0.0	0.0	Catheter replacement of the needle in percutaneous arteriography; a new technique.	S I SELDINGER	Acta radiol	1953	13057644	Yes
832	3533	1766.5	73.45	36.7	Network biology: understanding the cell's functional organization.	Albert-László Barabási, Zoltán N Oltvai	Nat Rev Genet	2004	14735121	No
833	1766	1766.0	71.23	71.2	Epidemiology of viral hepatitis and hepatocellular carcinoma.	Hashem B El-Serag	Gastroenterology	2012	22537432	No
834	3531	1765.5	0.0	0.0	Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography.	R A Laskey, A D Mills	Eur J Biochem	1975	1175627	Yes
835	3529	1764.5	95.42	47.7	Hepatocellular carcinoma: epidemiology and molecular carcinogenesis.	Hashem B El-Serag, K Lenhard Rudolph	Gastroenterology	2007	17570226	No
836	3527	1763.5	0.0	0.0	The Social Readjustment Rating Scale.	T H Holmes, R H Rahe	J Psychosom Res	1967	6059863	Yes
837	3526	1763.0	77.9	39.0	Mammalian MAP kinase signalling cascades.	L Chang, M Karin	Nature	2001	11242034	No
838	3522	1761.0	105.15	52.6	Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology.	Marie-Christine Daniel, Didier Astruc	Chem Rev	2004	14719978	No
839	1760	1760.0	36.77	36.8	Mechanisms of type-I- and type-II-interferon-mediated signalling.	Leonidas C Platanias	Nat Rev Immunol	2005	15864272	No
840	1758	1758.0	0.0	0.0	SEDIMENTATION STUDIES OF THE SIZE AND SHAPE OF DNA.	F W STUDIER	J Mol Biol	1965	14290352	Yes
841	1757	1757.0	68.17	68.2	The unbiased estimation of number and sizes of arbitrary particles using the disector.	D C Sterio	J Microsc	1984	6737468	Yes
842	3514	1757.0	116.33	58.2	The number of people with glaucoma worldwide in 2010 and 2020.	H A Quigley, A T Broman	Br J Ophthalmol	2006	16488940	Yes
843	1755	1755.0	54.11	54.1	The heme oxygenase system: a regulator of second messenger gases.	M D Maines	Annu Rev Pharmacol Toxicol	1997	9131263	No
844	1753	1753.0	0.0	0.0	Muscle structure and theories of contraction.	A F HUXLEY	Prog Biophys Biophys Chem	1957	13485191	Yes
845	1753	1753.0	55.52	55.5	Carbonic anhydrases: novel therapeutic applications for inhibitors and activators.	Claudiu T Supuran	Nat Rev Drug Discov	2008	18167490	No
846	3505	1752.5	120.52	60.3	Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly.	J S Beckman, W H Koppenol	Am J Physiol	1996	8944624	No
847	1751	1751.0	57.47	57.5	Estimating causal effects from large data sets using propensity scores.	D B Rubin	Ann Intern Med	1997	9382394	No
848	13983	1747.9	551.51	68.9	The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.	D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C Siebert	N Engl J Med	1993	8366922	Yes
849	1747	1747.0	0.0	0.0	Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads.	P Cuatrecasas	J Biol Chem	1970	5432796	Yes
850	3494	1747.0	0.0	0.0	A method for determining the sedimentation behavior of enzymes: application to protein mixtures.	R G MARTIN, B N AMES	J Biol Chem	1961	13767412	Yes
851	3492	1746.0	102.28	51.1	Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.	M Matsuda, R A DeFronzo	Diabetes Care	1999	10480510	Yes
852	6983	1745.8	188.87	47.2	Matrix elasticity directs stem cell lineage specification.	Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E Discher	Cell	2006	16923388	Yes
853	1745	1745.0	73.57	73.6	Qualitative research: standards, challenges, and guidelines.	K Malterud	Lancet	2001	11513933	Yes
854	1744	1744.0	0.0	0.0	Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli.	G BERTANI	J Bacteriol	1951	14888646	Yes
855	1743	1743.0	103.61	103.6	Structural Model Evaluation and Modification: An Interval Estimation Approach.	J H Steiger	Multivariate Behav Res	1990	26794479	Yes
856	5225	1741.7	245.2	81.7	Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA.	G Muyzer, E C de Waal, A G Uitterlinden	Appl Environ Microbiol	1993	7683183	Yes
857	1740	1740.0	0.0	0.0	The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes.	S BOYDEN	J Exp Med	1962	13872176	Yes
858	1738	1738.0	53.64	53.6	The nuclear factor NF-kappaB pathway in inflammation.	Toby Lawrence	Cold Spring Harb Perspect Biol	2009	20457564	No
859	5205	1735.0	0.0	0.0	ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.	J MONOD, J WYMAN, J P CHANGEUX	J Mol Biol	1965	14343300	Yes
860	1733	1733.0	59.94	59.9	Molecular diversity of glutamate receptors and implications for brain function.	S Nakanishi	Science	1992	1329206	No
861	10394	1732.3	250.48	41.7	NMRPipe: a multidimensional spectral processing system based on UNIX pipes.	F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A Bax	J Biomol NMR	1995	8520220	Yes
862	1732	1732.0	47.46	47.5	Social controls on cell survival and cell death.	M C Raff	Nature	1992	1557121	No
863	1731	1731.0	0.0	0.0	Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters.	F F Jöbsis	Science	1977	929199	Yes
864	1730	1730.0	0.0	0.0	Stereochemistry of cooperative effects in haemoglobin.	M F Perutz	Nature	1970	5528785	Yes
865	1730	1730.0	78.27	78.3	International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results.	C Herrmann	J Psychosom Res	1997	9055211	No
866	3459	1729.5	130.83	65.4	A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.	Gary J Bennett, Y-K Xie	Pain	1988	2837713	Yes
867	3453	1726.5	135.14	67.6	Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being.	R M Ryan, E L Deci	Am Psychol	2000	11392867	Yes
868	3453	1726.5	86.41	43.2	Brown adipose tissue: function and physiological significance.	Barbara Cannon, Jan Nedergaard	Physiol Rev	2004	14715917	No
869	1726	1726.0	58.5	58.5	Formation and Structure of Self-Assembled Monolayers.	Abraham Ulman	Chem Rev	1996	11848802	Yes
870	1726	1726.0	32.27	32.3	ATM and related protein kinases: safeguarding genome integrity.	Yosef Shiloh	Nat Rev Cancer	2003	12612651	No
871	3442	1721.0	91.53	45.8	Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.	B A Reynolds, S Weiss	Science	1992	1553558	Yes
872	1721	1721.0	47.4	47.4	Negative refraction makes a perfect lens	Pendry	Phys Rev Lett	2000	11041972	Yes
873	10323	1720.5	331.71	55.3	A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group.	A S Levey, J P Bosch, J B Lewis, T Greene, N Rogers, D Roth	Ann Intern Med	1999	10075613	Yes
874	3439	1719.5	123.27	61.6	SPSS and SAS procedures for estimating indirect effects in simple mediation models.	Kristopher J Preacher, Andrew F Hayes	Behav Res Methods Instrum Comput	2004	15641418	Yes
875	5155	1718.3	133.55	44.5	MOLMOL: a program for display and analysis of macromolecular structures.	R Koradi, M Billeter, K Wüthrich	J Mol Graph	1996	8744573	Yes
876	3434	1717.0	72.27	36.1	The Wnt signaling pathway in development and disease.	Catriona Y Logan, Roel Nusse	Annu Rev Cell Dev Biol	2004	15473860	No
877	1714	1714.0	69.93	69.9	A classification of glycosyl hydrolases based on amino acid sequence similarities.	B Henrissat	Biochem J	1991	1747104	Yes
878	3427	1713.5	79.17	39.6	Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.	M Gossen, H Bujard	Proc Natl Acad Sci U S A	1992	1319065	Yes
879	1713	1713.0	38.56	38.6	Molecular bases for circadian clocks.	J C Dunlap	Cell	1999	9988221	No
880	1712	1712.0	37.37	37.4	CpG motifs in bacterial DNA and their immune effects.	Arthur M Krieg	Annu Rev Immunol	2002	11861616	No
881	3423	1711.5	71.98	36.0	Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals.	Rudolf Jaenisch, Adrian Bird	Nat Genet	2003	12610534	No
882	1707	1707.0	43.6	43.6	Pathways towards and away from Alzheimer's disease.	Mark P Mattson	Nature	2004	15295589	No
883	3414	1707.0	121.66	60.8	Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections.	Jeng-Da Chai, Martin Head-Gordon	Phys Chem Chem Phys	2008	18989472	Yes
884	1706	1706.0	0.0	0.0	MECHANISM OF SUSTAINED-ACTION MEDICATION. THEORETICAL ANALYSIS OF RATE OF RELEASE OF SOLID DRUGS DISPERSED IN SOLID MATRICES.	T HIGUCHI	J Pharm Sci	1963	14088963	Yes
885	3410	1705.0	146.98	73.5	The attention system of the human brain.	M I Posner, S E Petersen	Annu Rev Neurosci	1990	2183676	No
886	1705	1705.0	40.31	40.3	Theta oscillations in the hippocampus.	György Buzsáki	Neuron	2002	11832222	No
887	1705	1705.0	47.28	47.3	Dopamine, learning and motivation.	Roy A Wise	Nat Rev Neurosci	2004	15152198	No
888	15343	1704.8	1050.91	116.8	Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.	Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray	Int J Cancer	2015	25220842	Yes
889	5111	1703.7	112.34	37.4	EMBOSS: the European Molecular Biology Open Software Suite.	P Rice, I Longden, A Bleasby	Trends Genet	2000	10827456	Yes
890	1703	1703.0	0.0	0.0	The Michigan alcoholism screening test: the quest for a new diagnostic instrument.	M L Selzer	Am J Psychiatry	1971	5565851	Yes
891	1702	1702.0	43.82	43.8	A decade of molecular biology of retinoic acid receptors.	P Chambon	FASEB J	1996	8801176	No
892	1702	1702.0	80.45	80.5	Missing data analysis: making it work in the real world.	John W Graham	Annu Rev Psychol	2009	18652544	No
893	3403	1701.5	110.36	55.2	A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.	Y Matsumura, H Maeda	Cancer Res	1986	2946403	Yes
894	1700	1700.0	0.0	0.0	Protein denaturation.	C Tanford	Adv Protein Chem	1968	4882248	No
895	1698	1698.0	55.27	55.3	Superoxide radical and superoxide dismutases.	I Fridovich	Annu Rev Biochem	1995	7574505	No
896	1697	1697.0	0.0	0.0	The membrane actions of anesthetics and tranquilizers.	P Seeman	Pharmacol Rev	1972	4565956	No
897	3393	1696.5	104.76	52.4	Organization and expression of eucaryotic split genes coding for proteins.	R Breathnach, P Chambon	Annu Rev Biochem	1981	6791577	No
898	1696	1696.0	50.99	51.0	The blood-brain barrier in health and chronic neurodegenerative disorders.	Berislav V Zlokovic	Neuron	2008	18215617	No
899	1695	1695.0	41.21	41.2	Defensins: antimicrobial peptides of innate immunity.	Tomas Ganz	Nat Rev Immunol	2003	12949495	No
900	3390	1695.0	146.5	73.2	Extracellular vesicles: exosomes, microvesicles, and friends.	Graça Raposo, Willem Stoorvogel	J Cell Biol	2013	23420871	No
901	1694	1694.0	55.14	55.1	The importance of selenium to human health.	M P Rayman	Lancet	2000	10963212	No
902	1694	1694.0	0.0	0.0	On respiratory impairment in cancer cells.	O WARBURG	Science	1956	13351639	Yes
903	1692	1692.0	44.21	44.2	Animal mitochondrial genomes.	J L Boore	Nucleic Acids Res	1999	10101183	No
904	1690	1690.0	41.87	41.9	A clearer vision for in vivo imaging.	R Weissleder	Nat Biotechnol	2001	11283581	No
905	1690	1690.0	37.82	37.8	Metastasis to bone: causes, consequences and therapeutic opportunities.	Gregory R Mundy	Nat Rev Cancer	2002	12154351	No
906	3379	1689.5	72.1	36.0	Smad-dependent and Smad-independent pathways in TGF-beta family signalling.	Rik Derynck, Ying E Zhang	Nature	2003	14534577	No
907	1689	1689.0	64.89	64.9	Eye movements in reading and information processing: 20 years of research.	K Rayner	Psychol Bull	1998	9849112	No
908	1686	1686.0	56.31	56.3	Determination and analysis of urea and guanidine hydrochloride denaturation curves.	C N Pace	Methods Enzymol	1986	3773761	Yes
909	1685	1685.0	71.42	71.4	Secretory products of macrophages.	C F Nathan	J Clin Invest	1987	3543052	No
910	1685	1685.0	77.65	77.7	Specific impairments of planning.	T Shallice	Philos Trans R Soc Lond B Biol Sci	1982	6125971	Yes
911	1683	1683.0	61.23	61.2	Fetal origins of coronary heart disease.	D J Barker	BMJ	1995	7613432	No
912	3364	1682.0	101.0	50.5	Function and activation of NF-kappa B in the immune system.	P A Baeuerle, T Henkel	Annu Rev Immunol	1994	8011280	No
913	5043	1681.0	179.05	59.7	Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.	C E Murry, R B Jennings, K A Reimer	Circulation	1986	3769170	Yes
914	1681	1681.0	70.06	70.1	Human error: models and management.	J Reason	BMJ	2000	10720363	Yes
915	5039	1679.7	171.92	57.3	The brain's default network: anatomy, function, and relevance to disease.	Randy L Buckner, Jessica R Andrews-Hanna, Daniel L Schacter	Ann N Y Acad Sci	2008	18400922	No
916	1678	1678.0	52.26	52.3	Epidemiology of insomnia: what we know and what we still need to learn.	Maurice M Ohayon	Sleep Med Rev	2002	12531146	Yes
917	3355	1677.5	0.0	0.0	Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid.	A C Chang, S N Cohen	J Bacteriol	1978	149110	Yes
918	1677	1677.0	31.76	31.8	Mechanisms of alternative pre-messenger RNA splicing.	Douglas L Black	Annu Rev Biochem	2003	12626338	No
919	5028	1676.0	183.48	61.2	Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders.	C Lord, M Rutter, A Le Couteur	J Autism Dev Disord	1994	7814313	Yes
920	3352	1676.0	94.12	47.1	Cutaneous wound healing.	A J Singer, R A Clark	N Engl J Med	1999	10471461	No
921	1676	1676.0	59.73	59.7	Hazards of heavy metal contamination.	Lars Järup	Br Med Bull	2003	14757716	No
922	1676	1676.0	36.64	36.6	The complex language of chromatin regulation during transcription.	Shelley L Berger	Nature	2007	17522673	No
923	1676	1676.0	48.19	48.2	Mechanisms of hepatic fibrogenesis.	Scott L Friedman	Gastroenterology	2008	18471545	No
924	5027	1675.7	128.34	42.8	A new statistical method for haplotype reconstruction from population data.	M Stephens, N J Smith, P Donnelly	Am J Hum Genet	2001	11254454	Yes
925	1675	1675.0	50.23	50.2	Endoplasmic reticulum stress and the inflammatory basis of metabolic disease.	Gökhan S Hotamisligil	Cell	2010	20303879	No
926	5024	1674.7	174.46	58.2	Arlequin (version 3.0): an integrated software package for population genetics data analysis.	Laurent Excoffier, Guillaume Laval, Stefan Schneider	Evol Bioinform Online	2007	19325852	Yes
927	1674	1674.0	78.23	78.2	The Resonating Valence Bond State in La2CuO4 and Superconductivity.	P W Anderson	Science	1987	17818979	Yes
928	3347	1673.5	88.82	44.4	The acute respiratory distress syndrome.	L B Ware, M A Matthay	N Engl J Med	2000	10793167	No
929	1673	1673.0	36.81	36.8	Approaching the asymptote? Evolution and revolution in immunology.	C A Janeway	Cold Spring Harb Symp Quant Biol	1989	2700931	No
930	5018	1672.7	127.4	42.5	APE: Analyses of Phylogenetics and Evolution in R language.	Emmanuel Paradis, Julien Claude, Korbinian Strimmer	Bioinformatics	2004	14734327	Yes
931	1672	1672.0	83.85	83.8	A systematic method for clinical description and classification of personality variants. A proposal.	C R Cloninger	Arch Gen Psychiatry	1987	3579504	Yes
932	3344	1672.0	0.0	0.0	Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years.	J V Durnin, J Womersley	Br J Nutr	1974	4843734	Yes
933	1670	1670.0	59.41	59.4	Calbindin D-28k and parvalbumin in the rat nervous system.	M R Celio	Neuroscience	1990	2199841	Yes
934	1670	1670.0	49.0	49.0	Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details.	R D Pascual-Marqui	Methods Find Exp Clin Pharmacol	2002	12575463	No
935	3339	1669.5	105.99	53.0	Distributed hierarchical processing in the primate cerebral cortex.	D J Felleman, D C Van Essen	Cereb Cortex	1991	1822724	No
936	11676	1668.0	286.64	40.9	Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes.	Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman	Genome Biol	2002	12184808	Yes
937	3331	1665.5	98.28	49.1	Regulation of the mevalonate pathway.	J L Goldstein, M S Brown	Nature	1990	1967820	No
938	3330	1665.0	98.58	49.3	Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.	M Nei, T Gojobori	Mol Biol Evol	1986	3444411	Yes
939	1665	1665.0	60.02	60.0	The free-energy principle: a unified brain theory?	Karl Friston	Nat Rev Neurosci	2010	20068583	No
940	1664	1664.0	35.7	35.7	Signalling pathways of the TNF superfamily: a double-edged sword.	Bharat B Aggarwal	Nat Rev Immunol	2003	12949498	No
941	1664	1664.0	43.94	43.9	DAMPs, PAMPs and alarmins: all we need to know about danger.	Marco E Bianchi	J Leukoc Biol	2007	17032697	No
942	3327	1663.5	199.68	99.8	Stress, social support, and the buffering hypothesis.	S Cohen, T A Wills	Psychol Bull	1985	3901065	No
943	1663	1663.0	68.43	68.4	Simplified calculation of body-surface area.	R D Mosteller	N Engl J Med	1987	3657876	Yes
944	3326	1663.0	68.68	34.3	The fundamental role of epigenetic events in cancer.	Peter A Jones, Stephen B Baylin	Nat Rev Genet	2002	12042769	No
945	1663	1663.0	50.21	50.2	Accurate description of van der Waals complexes by density functional theory including empirical corrections.	Stefan Grimme	J Comput Chem	2004	15224390	Yes
946	4988	1662.7	147.47	49.2	GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants.	R A Jefferson, T A Kavanagh, M W Bevan	EMBO J	1987	3327686	Yes
947	3323	1661.5	0.0	0.0	A diagnostic interview: the schedule for affective disorders and schizophrenia.	J Endicott, R L Spitzer	Arch Gen Psychiatry	1978	678037	Yes
948	3321	1660.5	93.87	46.9	The endophenotype concept in psychiatry: etymology and strategic intentions.	Irving I Gottesman, Todd D Gould	Am J Psychiatry	2003	12668349	No
949	4981	1660.3	142.83	47.6	Canonical sampling through velocity rescaling.	Giovanni Bussi, Davide Donadio, Michele Parrinello	J Chem Phys	2007	17212484	Yes
950	3319	1659.5	90.06	45.0	Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.	Michael T Lin, M Flint Beal	Nature	2006	17051205	No
951	1656	1656.0	34.55	34.5	In situ hybridization: an improved whole-mount method for Xenopus embryos.	R M Harland	Methods Cell Biol	1991	1811161	Yes
952	1656	1656.0	39.09	39.1	TRP channels as cellular sensors.	David E Clapham	Nature	2003	14654832	No
953	1655	1655.0	50.06	50.1	The physiology of glucagon-like peptide 1.	Jens Juul Holst	Physiol Rev	2007	17928588	No
954	1654	1654.0	39.1	39.1	XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density.	D E McRee	J Struct Biol	1999	10222271	Yes
955	1653	1653.0	34.77	34.8	Systems biology: a brief overview.	Hiroaki Kitano	Science	2002	11872829	No
956	3305	1652.5	69.81	34.9	Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.	M Karin, Y Ben-Neriah	Annu Rev Immunol	2000	10837071	No
957	1652	1652.0	56.75	56.8	TGFβ signalling in context.	Joan Massagué	Nat Rev Mol Cell Biol	2012	22992590	No
958	3303	1651.5	101.18	50.6	Alzheimer's disease: the amyloid cascade hypothesis.	J A Hardy, G A Higgins	Science	1992	1566067	No
959	3298	1649.0	107.69	53.8	A simple and very efficient method for generating cDNA libraries.	U Gubler, B J Hoffman	Gene	1983	6198242	Yes
960	1648	1648.0	39.77	39.8	The immunopathogenesis of sepsis.	Jonathan Cohen	Nature	2002	12490963	No
961	1647	1647.0	0.0	0.0	Efficient trace-labelling of proteins with iodine.	A S McFARLANE	Nature	1958	13566175	Yes
962	1646	1646.0	45.78	45.8	The structure and regulation of protein phosphatases.	P Cohen	Annu Rev Biochem	1989	2549856	No
963	1645	1645.0	0.0	0.0	Analysis of bacteriophage T7 early RNAs and proteins on slab gels.	F W Studier	J Mol Biol	1973	4760132	Yes
964	4934	1644.7	187.09	62.4	Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data.	L Excoffier, P E Smouse, J M Quattro	Genetics	1992	1644282	Yes
965	1643	1643.0	74.59	74.6	Determination of glutathione and glutathione disulfide in biological samples.	M E Anderson	Methods Enzymol	1985	4088074	Yes
966	1642	1642.0	45.7	45.7	A theory of cortical responses.	Karl Friston	Philos Trans R Soc Lond B Biol Sci	2005	15937014	No
967	1641	1641.0	0.0	0.0	Transplacental carcinogenesis by stilbestrol.	J Folkman	N Engl J Med	1971	5556579	Yes
968	1639	1639.0	82.73	82.7	Predicting basal metabolic rate, new standards and review of previous work.	W N Schofield	Hum Nutr Clin Nutr	1985	4044297	Yes
969	1639	1639.0	0.0	0.0	A GENERALIZED WILCOXON TEST FOR COMPARING ARBITRARILY SINGLY-CENSORED SAMPLES.	E A GEHAN	Biometrika	1965	14341275	Yes
970	3277	1638.5	108.16	54.1	A receptor-mediated pathway for cholesterol homeostasis.	M S Brown, J L Goldstein	Science	1986	3513311	No
971	1636	1636.0	36.32	36.3	Protein modules and signalling networks.	T Pawson	Nature	1995	7531822	No
972	1636	1636.0	38.46	38.5	Mechanisms of intracellular protein transport.	J E Rothman	Nature	1994	7969419	No
973	14715	1635.0	329.14	36.6	Cytoscape: a software environment for integrated models of biomolecular interaction networks.	Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey Ideker	Genome Res	2003	14597658	Yes
974	3268	1634.0	0.0	0.0	On the size of the active site in proteases. I. Papain.	I Schechter, A Berger	Biochem Biophys Res Commun	1967	6035483	Yes
975	1634	1634.0	35.97	36.0	Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls.	R J Kaufman	Genes Dev	1999	10346810	No
976	3267	1633.5	0.0	0.0	Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.	P J Fraker, J C Speck	Biochem Biophys Res Commun	1978	637870	Yes
977	1633	1633.0	47.14	47.1	Mechanisms and genes of cellular suicide.	H Steller	Science	1995	7878463	No
978	4899	1633.0	98.74	32.9	Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.	Jason D Fontenot, Marc A Gavin, Alexander Y Rudensky	Nat Immunol	2003	12612578	Yes
979	1633	1633.0	30.73	30.7	Automated electron microscope tomography using robust prediction of specimen movements.	David N Mastronarde	J Struct Biol	2005	16182563	Yes
980	3265	1632.5	0.0	0.0	High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.	M N Berry, D S Friend	J Cell Biol	1969	4900611	Yes
981	3262	1631.0	83.1	41.5	The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.	A J Ridley, A Hall	Cell	1992	1643657	Yes
982	1631	1631.0	45.56	45.6	Protein kinase C and lipid signaling for sustained cellular responses.	Y Nishizuka	FASEB J	1995	7737456	No
983	1631	1631.0	51.16	51.2	Accurate Coulomb-fitting basis sets for H to Rn.	Florian Weigend	Phys Chem Chem Phys	2006	16633586	Yes
984	1630	1630.0	88.21	88.2	The quality of care. How can it be assessed?	A Donabedian	JAMA	1988	3045356	No
985	3260	1630.0	92.0	46.0	Leptin and the regulation of body weight in mammals.	J M Friedman, J L Halaas	Nature	1998	9796811	No
986	1630	1630.0	0.0	0.0	Diffusion-in-gel methods for immunological analysis.	O OUCHTERLONY	Prog Allergy	1958	13578996	Yes
987	3256	1628.0	93.18	46.6	Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.	P J Barnes, M Karin	N Engl J Med	1997	9091804	No
988	1626	1626.0	87.46	87.5	The Children's Depression, Inventory (CDI).	M Kovacs	Psychopharmacol Bull	1985	4089116	Yes
989	6502	1625.5	141.98	35.5	WebLogo: a sequence logo generator.	Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E Brenner	Genome Res	2004	15173120	Yes
990	1625	1625.0	40.72	40.7	Cellular mechanisms of insulin resistance.	G I Shulman	J Clin Invest	2000	10903330	No
991	1625	1625.0	0.0	0.0	The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.	R R PORTER	Biochem J	1959	14434282	Yes
992	1622	1622.0	44.86	44.9	Follicular helper CD4 T cells (TFH).	Shane Crotty	Annu Rev Immunol	2011	21314428	No
993	1621	1621.0	44.57	44.6	Calcium signaling.	D E Clapham	Cell	1995	7834745	No
994	1621	1621.0	0.0	0.0	Analysis of tissue and arterial blood temperatures in the resting human forearm.	H H PENNES	J Appl Physiol	1948	18887578	Yes
995	1620	1620.0	34.66	34.7	Antiviral actions of interferons.	C E Samuel	Clin Microbiol Rev	2001	11585785	No
996	1619	1619.0	46.74	46.7	The extracellular matrix: not just pretty fibrils.	Richard O Hynes	Science	2009	19965464	No
997	1618	1618.0	42.83	42.8	The global health burden of infection-associated cancers in the year 2002.	Donald Maxwell Parkin	Int J Cancer	2006	16404738	Yes
998	1614	1614.0	46.39	46.4	Flow-mediated endothelial mechanotransduction.	P F Davies	Physiol Rev	1995	7624393	No
999	1614	1614.0	39.36	39.4	Neutrophils and immunity: challenges and opportunities.	Carl Nathan	Nat Rev Immunol	2006	16498448	No
1000	4840	1613.3	151.25	50.4	Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors.	F E Harrell, K L Lee, D B Mark	Stat Med	1996	8668867	No
1001	1611	1611.0	37.21	37.2	Developmental regulation of the growth plate.	Henry M Kronenberg	Nature	2003	12748651	No
1002	1610	1610.0	31.9	31.9	Signaling--2000 and beyond.	T Hunter	Cell	2000	10647936	No
1003	3220	1610.0	64.16	32.1	Rho GTPases in cell biology.	Sandrine Etienne-Manneville, Alan Hall	Nature	2002	12478284	No
1004	3218	1609.0	0.0	0.0	Loss of recent memory after bilateral hippocampal lesions.	W B SCOVILLE, B MILNER	J Neurol Neurosurg Psychiatry	1957	13406589	Yes
1005	1608	1608.0	63.77	63.8	Plant products as antimicrobial agents.	M M Cowan	Clin Microbiol Rev	1999	10515903	No
1006	1607	1607.0	49.9	49.9	The molecular pathology of Alzheimer's disease.	D J Selkoe	Neuron	1991	1673054	No
1007	1607	1607.0	80.9	80.9	Role of Streptococcus mutans in human dental decay.	W J Loesche	Microbiol Rev	1986	3540569	No
1008	3213	1606.5	87.15	43.6	Measuring the thickness of the human cerebral cortex from magnetic resonance images.	B Fischl, A M Dale	Proc Natl Acad Sci U S A	2000	10984517	Yes
1009	1606	1606.0	41.35	41.4	Targeting PI3K signalling in cancer: opportunities, challenges and limitations.	Jeffrey A Engelman	Nat Rev Cancer	2009	19629070	No
1010	3211	1605.5	80.73	40.4	Base-calling of automated sequencer traces using phred. II. Error probabilities.	B Ewing, P Green	Genome Res	1998	9521922	Yes
1011	1605	1605.0	36.43	36.4	Role of angiogenesis in tumor growth and metastasis.	Judah Folkman	Semin Oncol	2002	12516034	No
1012	1604	1604.0	87.01	87.0	A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992.	E L Bradley	Arch Surg	1993	8489394	No
1013	1603	1603.0	52.4	52.4	Patterns of amino acids near signal-sequence cleavage sites.	G von Heijne	Eur J Biochem	1983	6852022	Yes
1014	1603	1603.0	32.67	32.7	Notch signalling: a simple pathway becomes complex.	Sarah J Bray	Nat Rev Mol Cell Biol	2006	16921404	No
1015	1602	1602.0	62.98	63.0	Social cognitive theory: an agentic perspective.	A Bandura	Annu Rev Psychol	2001	11148297	Yes
1016	1598	1598.0	64.39	64.4	The use of a plus-maze to measure anxiety in the mouse.	R G Lister	Psychopharmacology (Berl)	1987	3110839	Yes
1017	1598	1598.0	0.0	0.0	The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis.	U E Loening	Biochem J	1967	5339944	Yes
1018	3191	1595.5	92.85	46.4	Protein structure prediction on the Web: a case study using the Phyre server.	Lawrence A Kelley, Michael J E Sternberg	Nat Protoc	2009	19247286	Yes
1019	3190	1595.0	0.0	0.0	The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin.	J A Spudich, S Watt	J Biol Chem	1971	4254541	Yes
1020	1595	1595.0	34.32	34.3	DNA topoisomerases: structure, function, and mechanism.	J J Champoux	Annu Rev Biochem	2001	11395412	No
1021	3186	1593.0	0.0	0.0	Judgment under Uncertainty: Heuristics and Biases.	A Tversky, D Kahneman	Science	1974	17835457	Yes
1022	1591	1591.0	29.93	29.9	The regulation of E2F by pRB-family proteins.	N Dyson	Genes Dev	1998	9694791	No
1023	1591	1591.0	35.82	35.8	The expanding role of mitochondria in apoptosis.	X Wang	Genes Dev	2001	11711427	No
1024	1589	1589.0	43.88	43.9	The mitogen-activated protein kinase signal transduction pathway.	R J Davis	J Biol Chem	1993	8325833	No
1025	3177	1588.5	146.06	73.0	The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories.	P F Lovibond, S H Lovibond	Behav Res Ther	1995	7726811	Yes
1026	1588	1588.0	36.91	36.9	Thrombin signalling and protease-activated receptors.	S R Coughlin	Nature	2000	11001069	No
1027	17468	1588.0	381.94	34.7	Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.	Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P Mesirov	Proc Natl Acad Sci U S A	2005	16199517	Yes
1028	1587	1587.0	64.68	64.7	Health consequences of intimate partner violence.	Jacquelyn C Campbell	Lancet	2002	11965295	No
1029	4752	1584.0	117.47	39.2	Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR.	Michael W Pfaffl, Graham W Horgan, Leo Dempfle	Nucleic Acids Res	2002	11972351	Yes
1030	1584	1584.0	33.33	33.3	MicroRNA biogenesis: coordinated cropping and dicing.	V Narry Kim	Nat Rev Mol Cell Biol	2005	15852042	No
1031	1582	1582.0	0.0	0.0	The catecholamine hypothesis of affective disorders: a review of supporting evidence.	J J Schildkraut	Am J Psychiatry	1965	5319766	No
1032	1581	1581.0	80.17	80.2	Calmodulin plays a pivotal role in cellular regulation.	W Y Cheung	Science	1980	6243188	No
1033	1580	1580.0	45.31	45.3	Breast cancer and hormone-replacement therapy in the Million Women Study.	Valerie Beral	Lancet	2003	12927427	Yes
1034	1578	1578.0	79.0	79.0	Approximate entropy as a measure of system complexity.	S M Pincus	Proc Natl Acad Sci U S A	1991	11607165	Yes
1035	3154	1577.0	181.19	90.6	Stages and processes of self-change of smoking: toward an integrative model of change.	J O Prochaska, C C DiClemente	J Consult Clin Psychol	1983	6863699	Yes
1036	1577	1577.0	64.88	64.9	Keratoconus.	Y S Rabinowitz	Surv Ophthalmol	1998	9493273	No
1037	1576	1576.0	56.09	56.1	Inhibited spontaneous emission in solid-state physics and electronics.	Yablonovitch	Phys Rev Lett	1987	10034639	Yes
1038	6300	1575.0	283.23	70.8	The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire.	T F Heatherton, L T Kozlowski, R C Frecker, K O Fagerström	Br J Addict	1991	1932883	Yes
1039	1575	1575.0	43.86	43.9	Cancer chemoprevention with dietary phytochemicals.	Young-Joon Surh	Nat Rev Cancer	2003	14570043	No
1040	3149	1574.5	82.79	41.4	The future of genetic studies of complex human diseases.	N Risch, K Merikangas	Science	1996	8801636	Yes
1041	11009	1572.7	279.56	39.9	Induction of pluripotent stem cells from adult human fibroblasts by defined factors.	Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka	Cell	2007	18035408	Yes
1042	4715	1571.7	184.95	61.6	Parallel organization of functionally segregated circuits linking basal ganglia and cortex.	G E Alexander, M R DeLong, P L Strick	Annu Rev Neurosci	1986	3085570	No
1043	1571	1571.0	0.0	0.0	Evaluating the quality of medical care.	A Donabedian	Milbank Mem Fund Q	1966	5338568	No
1044	1570	1570.0	66.44	66.4	Prooxidant states and tumor promotion.	P A Cerutti	Science	1985	2981433	No
1045	1570	1570.0	49.04	49.0	Bcl-2 and the regulation of programmed cell death.	J C Reed	J Cell Biol	1994	8294493	No
1046	1569	1569.0	48.3	48.3	Hepatitis B virus infection.	W M Lee	N Engl J Med	1997	9392700	No
1047	3132	1566.0	70.94	35.5	Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia.	C D Nobes, A Hall	Cell	1995	7536630	Yes
1048	1566	1566.0	43.08	43.1	Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver.	Scott L Friedman	Physiol Rev	2008	18195085	No
1049	1565	1565.0	0.0	0.0	Inositol phospholipids and cell surface receptor function.	R H Michell	Biochim Biophys Acta	1975	164246	No
1050	3130	1565.0	93.99	47.0	Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium.	Kresse, Hafner	Phys Rev B Condens Matter	1994	10010505	Yes
1051	1562	1562.0	42.73	42.7	Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity.	G Trinchieri	Annu Rev Immunol	1995	7612223	No
1052	3124	1562.0	72.49	36.2	Cell death: critical control points.	Nika N Danial, Stanley J Korsmeyer	Cell	2004	14744432	No
1053	1562	1562.0	0.0	0.0	Notes on sugar determination.	M SMOGYI	J Biol Chem	1952	14938350	Yes
1054	1561	1561.0	38.81	38.8	The distribution of secondary growths in cancer of the breast. 1889.	S Paget	Cancer Metastasis Rev	1989	2673568	No
1055	1560	1560.0	43.97	44.0	Interfaces and the driving force of hydrophobic assembly.	David Chandler	Nature	2005	16193038	No
1056	1557	1557.0	36.52	36.5	Exploring complex networks.	S H Strogatz	Nature	2001	11258382	No
1057	3113	1556.5	93.32	46.7	Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.	G G Glenner, C W Wong	Biochem Biophys Res Commun	1984	6375662	Yes
1058	3113	1556.5	72.43	36.2	Lessons from hereditary colorectal cancer.	K W Kinzler, B Vogelstein	Cell	1996	8861899	No
1059	6221	1555.2	244.42	61.1	Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.	A J Hughes, S E Daniel, L Kilford, A J Lees	J Neurol Neurosurg Psychiatry	1992	1564476	Yes
1060	6217	1554.2	166.48	41.6	Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels.	A Shevchenko, M Wilm, O Vorm, M Mann	Anal Chem	1996	8779443	Yes
1061	3106	1553.0	99.29	49.6	The heat-shock proteins.	S Lindquist, E A Craig	Annu Rev Genet	1988	2853609	No
1062	3105	1552.5	129.02	64.5	The biofilm matrix.	Hans-Curt Flemming, Jost Wingender	Nat Rev Microbiol	2010	20676145	No
1063	1552	1552.0	44.76	44.8	Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials.	Fiona Turnbull	Lancet	2003	14615107	Yes
1064	1552	1552.0	39.43	39.4	Integrating cell-signalling pathways with NF-kappaB and IKK function.	Neil D Perkins	Nat Rev Mol Cell Biol	2007	17183360	No
1065	3103	1551.5	0.0	0.0	Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method.	R B Devereux, N Reichek	Circulation	1977	138494	Yes
1066	6206	1551.5	302.17	75.5	A simple technique for quantitation of low levels of DNA damage in individual cells.	N P Singh, M T McCoy, R R Tice, E L Schneider	Exp Cell Res	1988	3345800	Yes
1067	4653	1551.0	177.18	59.1	Cell death: the significance of apoptosis.	A H Wyllie, J F Kerr, A R Currie	Int Rev Cytol	1980	7014501	No
1068	4653	1551.0	187.4	62.5	AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet.	P G Reeves, F H Nielsen, G C Fahey	J Nutr	1993	8229312	No
1069	3101	1550.5	0.0	0.0	Acetylornithinase of Escherichia coli: partial purification and some properties.	H J VOGEL, D M BONNER	J Biol Chem	1956	13278318	Yes
1070	1549	1549.0	0.0	0.0	Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu.	M J Casadaban	J Mol Biol	1976	781293	Yes
1071	1549	1549.0	76.56	76.6	Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases.	B N Ames	Science	1983	6351251	No
1072	1548	1548.0	35.88	35.9	Structure and regulation of voltage-gated Ca2+ channels.	W A Catterall	Annu Rev Cell Dev Biol	2000	11031246	No
1073	1548	1548.0	40.49	40.5	Global cancer statistics in the year 2000.	D M Parkin	Lancet Oncol	2001	11905707	No
1074	1547	1547.0	61.22	61.2	Epidemiological features of chronic low-back pain.	G B Andersson	Lancet	1999	10470716	No
1075	7722	1544.4	204.99	41.0	Mapping and quantifying mammalian transcriptomes by RNA-Seq.	Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara Wold	Nat Methods	2008	18516045	Yes
1076	3088	1544.0	152.43	76.2	Multiwfn: a multifunctional wavefunction analyzer.	Tian Lu, Feiwu Chen	J Comput Chem	2012	22162017	Yes
1077	1543	1543.0	0.0	0.0	Comparison of the predicted and observed secondary structure of T4 phage lysozyme.	B W Matthews	Biochim Biophys Acta	1975	1180967	Yes
1078	3084	1542.0	114.93	57.5	Efficient pseudopotentials for plane-wave calculations.	Troullier, Martins	Phys Rev B Condens Matter	1991	9997467	Yes
1079	3083	1541.5	97.62	48.8	Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction.	P Liang, A B Pardee	Science	1992	1354393	Yes
1080	3082	1541.0	89.11	44.6	Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering	Nie, Emory	Science	1997	9027306	Yes
1081	1540	1540.0	59.25	59.2	ATP-regulated K+ channels in cardiac muscle.	A Noma	Nature	1983	6310409	Yes
1082	1539	1539.0	36.69	36.7	A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics.	J SantaLucia	Proc Natl Acad Sci U S A	1998	9465037	Yes
1083	3078	1539.0	71.69	35.8	Monocyte and macrophage heterogeneity.	Siamon Gordon, Philip R Taylor	Nat Rev Immunol	2005	16322748	No
1084	1538	1538.0	0.0	0.0	Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults.	O SMITHIES	Biochem J	1955	13276348	Yes
1085	1538	1538.0	47.83	47.8	Intestinal mucosal barrier function in health and disease.	Jerrold R Turner	Nat Rev Immunol	2009	19855405	No
1086	1536	1536.0	56.08	56.1	Protein oxidation and aging.	E R Stadtman	Science	1992	1355616	No
1087	1536	1536.0	0.0	0.0	Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?	J V NEEL	Am J Hum Genet	1962	13937884	Yes
1088	3066	1533.0	168.9	84.5	The Health Belief Model: a decade later.	N K Janz, M H Becker	Health Educ Q	1984	6392204	No
1089	3065	1532.5	0.0	0.0	Some quantitative uses of drug antagonists.	O ARUNLAKSHANA, H O SCHILD	Br J Pharmacol Chemother	1959	13651579	Yes
1090	4594	1531.3	178.92	59.6	Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire.	R L Spitzer, K Kroenke, J B Williams	JAMA	1999	10568646	Yes
1091	1531	1531.0	59.11	59.1	Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.	R A DeFronzo	Diabetes	1988	3289989	No
1092	6123	1530.8	170.85	42.7	Epithelial-mesenchymal transitions in development and disease.	Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela Nieto	Cell	2009	19945376	No
1093	3059	1529.5	107.3	53.6	Wnt/β-catenin signaling and disease.	Hans Clevers, Roel Nusse	Cell	2012	22682243	No
1094	1526	1526.0	34.25	34.2	Molecular regulation of vessel maturation.	Rakesh K Jain	Nat Med	2003	12778167	No
1095	1525	1525.0	42.73	42.7	Evolutionary relationship of DNA sequences in finite populations.	F Tajima	Genetics	1983	6628982	Yes
1096	3050	1525.0	0.0	0.0	A SIMPLIFIED LEAD CITRATE STAIN FOR USE IN ELECTRON MICROSCOPY.	J H VENABLE, R COGGESHALL	J Cell Biol	1965	14287192	Yes
1097	3049	1524.5	99.37	49.7	Nonparametric statistical testing of EEG- and MEG-data.	Eric Maris, Robert Oostenveld	J Neurosci Methods	2007	17517438	Yes
1098	4572	1524.0	0.0	0.0	Glucose clamp technique: a method for quantifying insulin secretion and resistance.	R A DeFronzo, J D Tobin, R Andres	Am J Physiol	1979	382871	Yes
1099	1524	1524.0	53.77	53.8	Excitotoxic cell death.	D W Choi	J Neurobiol	1992	1361523	No
1100	1523	1523.0	105.87	105.9	Determination and quantification of content validity.	M R Lynn	Nurs Res	1986	3640358	Yes
1101	1519	1519.0	49.34	49.3	Biofilms: microbial life on surfaces.	Rodney M Donlan	Emerg Infect Dis	2002	12194761	No
1102	3035	1517.5	92.17	46.1	The inflammasomes.	Kate Schroder, Jurg Tschopp	Cell	2010	20303873	No
1103	1516	1516.0	66.63	66.6	Doxil®--the first FDA-approved nano-drug: lessons learned.	Yechezkel Barenholz	J Control Release	2012	22484195	No
1104	3030	1515.0	78.94	39.5	CAP3: A DNA sequence assembly program.	X Huang, A Madan	Genome Res	1999	10508846	Yes
1105	3027	1513.5	0.0	0.0	Mathematical model for studying genetic variation in terms of restriction endonucleases.	M Nei, W H Li	Proc Natl Acad Sci U S A	1979	291943	Yes
1106	3026	1513.0	93.1	46.5	Assembly of asparagine-linked oligosaccharides.	R Kornfeld, S Kornfeld	Annu Rev Biochem	1985	3896128	No
1107	1513	1513.0	41.58	41.6	The genetics of ageing.	Cynthia J Kenyon	Nature	2010	20336132	No
1108	1512	1512.0	32.55	32.5	The synaptic vesicle cycle.	Thomas C Sudhof	Annu Rev Neurosci	2004	15217342	No
1109	3023	1511.5	162.9	81.5	The MOS social support survey.	C D Sherbourne, A L Stewart	Soc Sci Med	1991	2035047	Yes
1110	1511	1511.0	0.0	0.0	Removal of fatty acids from serum albumin by charcoal treatment.	R F Chen	J Biol Chem	1967	6016603	Yes
1111	1511	1511.0	71.65	71.7	Why patients use alternative medicine: results of a national study.	J A Astin	JAMA	1998	9605899	Yes
1112	3021	1510.5	0.0	0.0	A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase.	R F BEERS, I W SIZER	J Biol Chem	1952	14938361	Yes
1113	1510	1510.0	0.0	0.0	The plasma lecithins:cholesterol acyltransferase reaction.	J A Glomset	J Lipid Res	1968	4868699	No
1114	3020	1510.0	0.0	0.0	A complementation analysis of the restriction and modification of DNA in Escherichia coli.	H W Boyer, D Roulland-Dussoix	J Mol Biol	1969	4896022	Yes
1115	1510	1510.0	51.75	51.8	Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.	A Dunaif	Endocr Rev	1997	9408743	No
1116	4527	1509.0	0.0	0.0	Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.	B N Ames, J Mccann, E Yamasaki	Mutat Res	1975	768755	Yes
1117	1509	1509.0	30.58	30.6	CD4+ CD25+ suppressor T cells: more questions than answers.	Ethan M Shevach	Nat Rev Immunol	2002	12093005	No
1118	1509	1509.0	64.31	64.3	Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope.	Lutz Ackermann	Chem Rev	2011	21391562	Yes
1119	3017	1508.5	97.74	48.9	Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.	K D McCarthy, J de Vellis	J Cell Biol	1980	6248568	Yes
1120	4524	1508.0	131.94	44.0	Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.	G S Hotamisligil, N S Shargill, B M Spiegelman	Science	1993	7678183	Yes
1121	1507	1507.0	40.95	41.0	Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures.	D Lavanchy	J Viral Hepat	2004	14996343	No
1122	3012	1506.0	169.05	84.5	The Brief Symptom Inventory: an introductory report.	L R Derogatis, N Melisaratos	Psychol Med	1983	6622612	Yes
1123	1505	1505.0	39.67	39.7	Metabolomics--the link between genotypes and phenotypes.	Oliver Fiehn	Plant Mol Biol	2002	11860207	No
1124	1505	1505.0	0.0	0.0	SELECTION OF HYBRIDS FROM MATINGS OF FIBROBLASTS IN VITRO AND THEIR PRESUMED RECOMBINANTS.	J W LITTLEFIELD	Science	1964	14168277	Yes
1125	1505	1505.0	32.11	32.1	DNA methylation and human disease.	Keith D Robertson	Nat Rev Genet	2005	16136652	No
1126	3009	1504.5	140.54	70.3	miRBase: annotating high confidence microRNAs using deep sequencing data.	Ana Kozomara, Sam Griffiths-Jones	Nucleic Acids Res	2014	24275495	Yes
1127	1504	1504.0	104.05	104.0	The assessment of clinical skills/competence/performance.	G E Miller	Acad Med	1990	2400509	Yes
1128	3008	1504.0	84.73	42.4	A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.	G Shaw, R Kamen	Cell	1986	3488815	Yes
1129	3008	1504.0	0.0	0.0	Variations in pattern of pubertal changes in girls.	W A Marshall, J M Tanner	Arch Dis Child	1969	5785179	Yes
1130	1504	1504.0	84.91	84.9	Detecting alcoholism. The CAGE questionnaire.	J A Ewing	JAMA	1984	6471323	Yes
1131	1503	1503.0	0.0	0.0	Mechanisms of action of transmitters and other substances on smooth muscle.	T B Bolton	Physiol Rev	1979	37533	No
1132	1503	1503.0	0.0	0.0	Dendritic organization in the neurons of the visual and motor cortices of the cat.	D A SHOLL	J Anat	1953	13117757	Yes
1133	4504	1501.3	184.96	61.7	featureCounts: an efficient general purpose program for assigning sequence reads to genomic features.	Yang Liao, Gordon K Smyth, Wei Shi	Bioinformatics	2014	24227677	Yes
1134	1501	1501.0	72.73	72.7	Role of nrf2 in oxidative stress and toxicity.	Qiang Ma	Annu Rev Pharmacol Toxicol	2013	23294312	No
1135	1500	1500.0	0.0	0.0	Oxygen-dependent microbial killing by phagocytes (first of two parts).	B M Babior	N Engl J Med	1978	24176	Yes
1136	1500	1500.0	0.0	0.0	A theory of cerebellar cortex.	D Marr	J Physiol	1969	5784296	Yes
1137	1497	1497.0	34.89	34.9	Excitatory actions of gaba during development: the nature of the nurture.	Yehezkel Ben-Ari	Nat Rev Neurosci	2002	12209121	No
1138	1496	1496.0	47.06	47.1	The comet assay for DNA damage and repair: principles, applications, and limitations.	Andrew R Collins	Mol Biotechnol	2004	15004294	No
1139	4488	1496.0	155.61	51.9	FastTree 2--approximately maximum-likelihood trees for large alignments.	Morgan N Price, Paramvir S Dehal, Adam P Arkin	PLoS One	2010	20224823	Yes
1140	1495	1495.0	52.64	52.6	The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation.	G P Chrousos	N Engl J Med	1995	7715646	No
1141	7475	1495.0	229.52	45.9	Global prevalence of diabetes: estimates for the year 2000 and projections for 2030.	Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary King	Diabetes Care	2004	15111519	Yes
1142	1495	1495.0	51.51	51.5	Social determinants of health inequalities.	Michael Marmot	Lancet	2005	15781105	Yes
1143	1493	1493.0	33.31	33.3	Protein homology detection by HMM-HMM comparison.	Johannes Söding	Bioinformatics	2005	15531603	Yes
1144	1493	1493.0	46.25	46.2	MYC on the path to cancer.	Chi V Dang	Cell	2012	22464321	No
1145	2984	1492.0	86.9	43.5	Building better batteries.	M Armand, J-M Tarascon	Nature	2008	18256660	No
1146	1491	1491.0	0.0	0.0	Chemiosmotic coupling in oxidative and photosynthetic phosphorylation.	P Mitchell	Biol Rev Camb Philos Soc	1966	5329743	No
1147	1490	1490.0	30.16	30.2	Cellular roles of DNA topoisomerases: a molecular perspective.	James C Wang	Nat Rev Mol Cell Biol	2002	12042765	No
1148	1489	1489.0	61.83	61.8	Physiological actions of taurine.	R J Huxtable	Physiol Rev	1992	1731369	No
1149	1488	1488.0	46.58	46.6	Thioredoxin.	A Holmgren	Annu Rev Biochem	1985	3896121	No
1150	1488	1488.0	47.56	47.6	Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic.	Robert E Marx	J Oral Maxillofac Surg	2003	12966493	Yes
1151	4462	1487.3	91.89	30.6	Surfing the p53 network.	B Vogelstein, D Lane, A J Levine	Nature	2000	11099028	No
1152	1487	1487.0	30.12	30.1	Generating samples under a Wright-Fisher neutral model of genetic variation.	Richard R Hudson	Bioinformatics	2002	11847089	Yes
1153	1487	1487.0	58.27	58.3	Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium.	Sergio Pecorelli	Int J Gynaecol Obstet	2009	19367689	No
1154	1487	1487.0	79.96	80.0	Microplastics in the marine environment.	Anthony L Andrady	Mar Pollut Bull	2011	21742351	No
1155	1486	1486.0	31.36	31.4	Cancer and the chemokine network.	Fran Balkwill	Nat Rev Cancer	2004	15229479	No
1156	1486	1486.0	42.68	42.7	Using circular dichroism spectra to estimate protein secondary structure.	Norma J Greenfield	Nat Protoc	2006	17406547	Yes
1157	2971	1485.5	89.47	44.7	The mirror-neuron system.	Giacomo Rizzolatti, Laila Craighero	Annu Rev Neurosci	2004	15217330	No
1158	1485	1485.0	43.08	43.1	Drug-like properties and the causes of poor solubility and poor permeability.	C A Lipinski	J Pharmacol Toxicol Methods	2000	11274893	No
1159	1485	1485.0	56.96	57.0	An overview of brominated flame retardants in the environment.	Cynthia A de Wit	Chemosphere	2002	11999784	No
1160	1485	1485.0	52.92	52.9	Global epidemiology of oral and oropharyngeal cancer.	Saman Warnakulasuriya	Oral Oncol	2009	18804401	No
1161	4453	1484.3	227.83	75.9	HISAT: a fast spliced aligner with low memory requirements.	Daehwan Kim, Ben Langmead, Steven L Salzberg	Nat Methods	2015	25751142	Yes
1162	1483	1483.0	50.94	50.9	Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance.	F Rousset	Genetics	1997	9093870	Yes
1163	1483	1483.0	40.79	40.8	The dawning era of polymer therapeutics.	Ruth Duncan	Nat Rev Drug Discov	2003	12750738	No
1164	1481	1481.0	0.0	0.0	Presidential Address-1976. Social support as a moderator of life stress.	S Cobb	Psychosom Med	1976	981490	Yes
1165	1480	1480.0	0.0	0.0	Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry.	M Wong-Riley	Brain Res	1979	223730	Yes
1166	1480	1480.0	32.93	32.9	Mechanisms of cancer drug resistance.	Michael M Gottesman	Annu Rev Med	2002	11818492	No
1167	2955	1477.5	59.69	29.8	SIFT: Predicting amino acid changes that affect protein function.	Pauline C Ng, Steven Henikoff	Nucleic Acids Res	2003	12824425	Yes
1168	1477	1477.0	44.18	44.2	Signal sequences. The limits of variation.	G von Heijne	J Mol Biol	1985	4032478	Yes
1169	1477	1477.0	35.91	35.9	Recognition of microorganisms and activation of the immune response.	Ruslan Medzhitov	Nature	2007	17943118	No
1170	5906	1476.5	123.06	30.8	Stem cells, cancer, and cancer stem cells.	T Reya, S J Morrison, M F Clarke, I L Weissman	Nature	2001	11689955	No
1171	2953	1476.5	72.89	36.4	Parkinson's disease: mechanisms and models.	William Dauer, Serge Przedborski	Neuron	2003	12971891	No
1172	1476	1476.0	66.63	66.6	Heavy metal intensification of DAB-based HRP reaction product.	J C Adams	J Histochem Cytochem	1981	7252134	Yes
1173	2950	1475.0	120.36	60.2	Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.	G Di Chiara, A Imperato	Proc Natl Acad Sci U S A	1988	2899326	Yes
1174	2948	1474.0	0.0	0.0	An efficient mRNA-dependent translation system from reticulocyte lysates.	H R Pelham, R J Jackson	Eur J Biochem	1976	823012	Yes
1175	1474	1474.0	0.0	0.0	A classification of hand preference by association analysis.	M Annett	Br J Psychol	1970	5457503	Yes
1176	1473	1473.0	49.77	49.8	PsychoPy--Psychophysics software in Python.	Jonathan W Peirce	J Neurosci Methods	2007	17254636	Yes
1177	2943	1471.5	74.53	37.3	Identification of common molecular subsequences.	T F Smith, M S Waterman	J Mol Biol	1981	7265238	Yes
1178	5885	1471.2	261.01	65.3	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	J Clin Epidemiol	2009	19631508	No
1179	1471	1471.0	32.46	32.5	The effect of infections on susceptibility to autoimmune and allergic diseases.	Jean-Francois Bach	N Engl J Med	2002	12239261	No
1180	2942	1471.0	76.07	38.0	Liver fibrosis.	Ramón Bataller, David A Brenner	J Clin Invest	2005	15690074	No
1181	2938	1469.0	95.29	47.6	Biofilms: survival mechanisms of clinically relevant microorganisms.	Rodney M Donlan, J William Costerton	Clin Microbiol Rev	2002	11932229	No
1182	1469	1469.0	44.32	44.3	THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons.	Kozi Asada	Annu Rev Plant Physiol Plant Mol Biol	1999	15012221	Yes
1183	1468	1468.0	0.0	0.0	The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides.	G S Manning	Q Rev Biophys	1978	353876	No
1184	2936	1468.0	80.54	40.3	Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.	Christian Haass, Dennis J Selkoe	Nat Rev Mol Cell Biol	2007	17245412	No
1185	2934	1467.0	0.0	0.0	Genetic regulatory mechanisms in the synthesis of proteins.	F JACOB, J MONOD	J Mol Biol	1961	13718526	Yes
1186	1466	1466.0	45.07	45.1	Chlorpromazine equivalent doses for the newer atypical antipsychotics.	Scott W Woods	J Clin Psychiatry	2003	12823080	No
1187	1464	1464.0	0.0	0.0	A rating instrument for anxiety disorders.	W W Zung	Psychosomatics	1971	5172928	Yes
1188	1464	1464.0	51.81	51.8	Hypoxia-inducible factors in physiology and medicine.	Gregg L Semenza	Cell	2012	22304911	No
1189	1463	1463.0	0.0	0.0	Positional information and the spatial pattern of cellular differentiation.	L Wolpert	J Theor Biol	1969	4390734	Yes
1190	1463	1463.0	52.57	52.6	A measure of population subdivision based on microsatellite allele frequencies.	M Slatkin	Genetics	1995	7705646	Yes
1191	1463	1463.0	35.86	35.9	Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury.	S L Friedman	J Biol Chem	2000	10644669	No
1192	1462	1462.0	38.18	38.2	The synaptic vesicle cycle: a cascade of protein-protein interactions.	T C Südhof	Nature	1995	7791897	No
1193	1462	1462.0	38.47	38.5	Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems.	S A Bustin	J Mol Endocrinol	2002	12200227	No
1194	1461	1461.0	86.38	86.4	Performance-oriented assessment of mobility problems in elderly patients.	M E Tinetti	J Am Geriatr Soc	1986	3944402	Yes
1195	1461	1461.0	47.95	48.0	Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis.	J Folkman	N Engl J Med	1995	7491141	No
1196	1461	1461.0	37.12	37.1	Fabrication of novel biomaterials through molecular self-assembly.	Shuguang Zhang	Nat Biotechnol	2003	14520402	No
1197	4378	1459.3	98.13	32.7	A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays.	Zhang, Chung, Oldenburg	J Biomol Screen	1999	10838414	Yes
1198	10213	1459.0	450.56	64.4	Assessing the quality of reports of randomized clinical trials: is blinding necessary?	A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuay	Control Clin Trials	1996	8721797	Yes
1199	2918	1459.0	89.16	44.6	ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT.	B Ravel, M Newville	J Synchrotron Radiat	2005	15968136	Yes
1200	1458	1458.0	56.71	56.7	Archaea in coastal marine environments.	E F DeLong	Proc Natl Acad Sci U S A	1992	1608980	Yes
1201	1458	1458.0	56.52	56.5	Diagnosis of Alzheimer's disease.	Z S Khachaturian	Arch Neurol	1985	2864910	Yes
1202	1458	1458.0	54.29	54.3	Grounded cognition.	Lawrence W Barsalou	Annu Rev Psychol	2008	17705682	No
1203	2913	1456.5	90.95	45.5	The unfolded protein response: from stress pathway to homeostatic regulation.	Peter Walter, David Ron	Science	2011	22116877	No
1204	1456	1456.0	38.59	38.6	Type III protein secretion systems in bacterial pathogens of animals and plants.	C J Hueck	Microbiol Mol Biol Rev	1998	9618447	No
1205	5823	1455.8	157.4	39.4	Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.	C A Lipinski, F Lombardo, B W Dominy, P J Feeney	Adv Drug Deliv Rev	2001	11259830	No
1206	2911	1455.5	75.38	37.7	Neuronal oscillations in cortical networks.	György Buzsáki, Andreas Draguhn	Science	2004	15218136	No
1207	1455	1455.0	38.1	38.1	G1 events and regulation of cell proliferation.	A B Pardee	Science	1989	2683075	No
1208	1454	1454.0	35.37	35.4	AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.	D Grahame Hardie	Nat Rev Mol Cell Biol	2007	17712357	No
1209	5807	1451.8	252.74	63.2	Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses.	Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg Lang	Behav Res Methods	2009	19897823	Yes
1210	5804	1451.0	225.99	56.5	A brief measure for assessing generalized anxiety disorder: the GAD-7.	Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd Löwe	Arch Intern Med	2006	16717171	Yes
1211	1451	1451.0	48.61	48.6	Infrared spectroscopy of proteins.	Andreas Barth	Biochim Biophys Acta	2007	17692815	No
1212	5802	1450.5	235.61	58.9	SignalP 4.0: discriminating signal peptides from transmembrane regions.	Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik Nielsen	Nat Methods	2011	21959131	Yes
1213	5801	1450.2	161.51	40.4	Cancer-related inflammation.	Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill	Nature	2008	18650914	No
1214	1449	1449.0	0.0	0.0	A study of the adrenotropic receptors.	R P AHLQUIST	Am J Physiol	1948	18882199	Yes
1215	2897	1448.5	67.72	33.9	Insulin signalling and the regulation of glucose and lipid metabolism.	A R Saltiel, C R Kahn	Nature	2001	11742412	Yes
1216	1447	1447.0	42.52	42.5	An index to quantify an individual's scientific research output.	J E Hirsch	Proc Natl Acad Sci U S A	2005	16275915	Yes
1217	2887	1443.5	0.0	0.0	PREPARATION OF FATTY ACID METHYL ESTERS AND DIMETHYLACETALS FROM LIPIDS WITH BORON FLUORIDE--METHANOL.	W R MORRISON, L M SMITH	J Lipid Res	1964	14221106	Yes
1218	1442	1442.0	0.0	0.0	Purinergic nerves.	G Burnstock	Pharmacol Rev	1972	4404211	No
1219	1441	1441.0	0.0	0.0	Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate.	J P Chamberlain	Anal Biochem	1979	543547	Yes
1220	1441	1441.0	48.46	48.5	Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996.	E M Wassermann	Electroencephalogr Clin Neurophysiol	1998	9474057	No
1221	1441	1441.0	40.58	40.6	Clinical application of C-reactive protein for cardiovascular disease detection and prevention.	Paul M Ridker	Circulation	2003	12551853	No
1222	2881	1440.5	83.56	41.8	Receptors for purines and pyrimidines.	V Ralevic, G Burnstock	Pharmacol Rev	1998	9755289	No
1223	1440	1440.0	38.7	38.7	Angiogenesis: an organizing principle for drug discovery?	Judah Folkman	Nat Rev Drug Discov	2007	17396134	No
1224	1439	1439.0	0.0	0.0	The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers.	D E Atkinson	Biochemistry	1968	4972613	Yes
1225	1438	1438.0	76.44	76.4	A rating scale for drug-induced akathisia.	T R Barnes	Br J Psychiatry	1989	2574607	Yes
1226	1438	1438.0	56.22	56.2	Sick individuals and sick populations.	G Rose	Int J Epidemiol	1985	3872850	Yes
1227	1437	1437.0	43.95	44.0	Interleukin-2: inception, impact, and implications.	K A Smith	Science	1988	3131876	No
1228	2874	1437.0	95.25	47.6	Insulin-like growth factors and their binding proteins: biological actions.	J I Jones, D R Clemmons	Endocr Rev	1995	7758431	No
1229	1437	1437.0	28.05	28.1	Maximum-likelihood density modification.	T C Terwilliger	Acta Crystallogr D Biol Crystallogr	2000	10944333	Yes
1230	2874	1437.0	107.88	53.9	Understanding interobserver agreement: the kappa statistic.	Anthony J Viera, Joanne M Garrett	Fam Med	2005	15883903	Yes
1231	2873	1436.5	0.0	0.0	Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy.	I W McLean, P K Nakane	J Histochem Cytochem	1974	4374474	Yes
1232	5746	1436.5	145.36	36.3	Transformation of intact yeast cells treated with alkali cations.	H Ito, Y Fukuda, K Murata, A Kimura	J Bacteriol	1983	6336730	Yes
1233	2873	1436.5	67.36	33.7	Integrin signaling.	F G Giancotti, E Ruoslahti	Science	1999	10446041	No
1234	2872	1436.0	75.79	37.9	Amino acid substitution matrices from protein blocks.	S Henikoff, J G Henikoff	Proc Natl Acad Sci U S A	1992	1438297	Yes
1235	1436	1436.0	39.64	39.6	Inflammatory bowel disease: etiology and pathogenesis.	C Fiocchi	Gastroenterology	1998	9649475	No
1236	1436	1436.0	39.11	39.1	Episodic memory: from mind to brain.	Endel Tulving	Annu Rev Psychol	2002	11752477	Yes
1237	1436	1436.0	43.04	43.0	What is cognitive reserve? Theory and research application of the reserve concept.	Yaakov Stern	J Int Neuropsychol Soc	2002	11939702	No
1238	2870	1435.0	120.42	60.2	Oxygen toxicity, oxygen radicals, transition metals and disease.	B Halliwell, J M Gutteridge	Biochem J	1984	6326753	No
1239	2870	1435.0	84.29	42.1	Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes.	Steven E Nissen, Kathy Wolski	N Engl J Med	2007	17517853	Yes
1240	1433	1433.0	36.81	36.8	Chemokines.	B J Rollins	Blood	1997	9242519	No
1241	1433	1433.0	29.37	29.4	Network motifs: theory and experimental approaches.	Uri Alon	Nat Rev Genet	2007	17510665	No
1242	1433	1433.0	36.17	36.2	The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.	Michael R Lieber	Annu Rev Biochem	2010	20192759	No
1243	2864	1432.0	107.82	53.9	Angiogenic factors.	J Folkman, M Klagsbrun	Science	1987	2432664	No
1244	1432	1432.0	62.52	62.5	Recognition-by-components: a theory of human image understanding.	Irving Biederman	Psychol Rev	1987	3575582	Yes
1245	1432	1432.0	33.65	33.6	Neuronal calcium signaling.	M J Berridge	Neuron	1998	9697848	No
1246	2863	1431.5	120.96	60.5	Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine.	M H Zweig, G Campbell	Clin Chem	1993	8472349	No
1247	4294	1431.3	119.51	39.8	Rapid and efficient site-specific mutagenesis without phenotypic selection.	T A Kunkel, J D Roberts, R A Zakour	Methods Enzymol	1987	3323813	Yes
1248	2862	1431.0	100.59	50.3	Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration.	B J Marshall, J R Warren	Lancet	1984	6145023	Yes
1249	1430	1430.0	49.71	49.7	Classification of inflammatory bowel disease.	J E Lennard-Jones	Scand J Gastroenterol Suppl	1989	2617184	Yes
1250	2857	1428.5	0.0	0.0	Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells.	J G Rheinwald, H Green	Cell	1975	1052771	Yes
1251	1428	1428.0	0.0	0.0	Towards a network theory of the immune system.	N K Jerne	Ann Immunol (Paris)	1974	4142565	No
1252	2856	1428.0	69.9	35.0	Raster3D: photorealistic molecular graphics.	E A Merritt, D J Bacon	Methods Enzymol	1997	18488322	Yes
1253	1426	1426.0	48.44	48.4	Introduction and General Overview of Cyclodextrin Chemistry.	József Szejtli	Chem Rev	1998	11848947	Yes
1254	2850	1425.0	99.93	50.0	New perspectives in cell adhesion: RGD and integrins.	E Ruoslahti, M D Pierschbacher	Science	1987	2821619	No
1255	1424	1424.0	34.0	34.0	Bone morphogenetic proteins: multifunctional regulators of vertebrate development.	B L Hogan	Genes Dev	1996	8682290	No
1256	2846	1423.0	82.1	41.0	Matrix metalloproteinases.	H Nagase, J F Woessner	J Biol Chem	1999	10419448	No
1257	2843	1421.5	74.52	37.3	PRODRG: a tool for high-throughput crystallography of protein-ligand complexes.	Alexander W Schüttelkopf, Daan M F van Aalten	Acta Crystallogr D Biol Crystallogr	2004	15272157	Yes
1258	1420	1420.0	45.56	45.6	Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution.	H LeVine	Protein Sci	1993	8453378	Yes
1259	2838	1419.0	68.47	34.2	Issues and challenges facing rechargeable lithium batteries.	J M Tarascon, M Armand	Nature	2001	11713543	Yes
1260	1419	1419.0	30.26	30.3	Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.	Judith Campisi	Cell	2005	15734683	No
1261	1418	1418.0	42.55	42.5	Neurotrophins and neuronal plasticity.	H Thoenen	Science	1995	7570017	No
1262	2836	1418.0	67.06	33.5	The epigenomics of cancer.	Peter A Jones, Stephen B Baylin	Cell	2007	17320506	No
1263	1418	1418.0	40.37	40.4	Network pharmacology: the next paradigm in drug discovery.	Andrew L Hopkins	Nat Chem Biol	2008	18936753	No
1264	1418	1418.0	56.37	56.4	Guided Search 2.0 A revised model of visual search.	J M Wolfe	Psychon Bull Rev	1994	24203471	Yes
1265	1417	1417.0	36.65	36.6	The retinal pigment epithelium in visual function.	Olaf Strauss	Physiol Rev	2005	15987797	No
1266	2834	1417.0	75.95	38.0	Origins and Mechanisms of miRNAs and siRNAs.	Richard W Carthew, Erik J Sontheimer	Cell	2009	19239886	No
1267	1416	1416.0	56.94	56.9	Calculation of substrate oxidation rates in vivo from gaseous exchange.	K N Frayn	J Appl Physiol Respir Environ Exerc Physiol	1983	6618956	Yes
1268	1416	1416.0	69.43	69.4	Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review.	H U Wittchen	J Psychiatr Res	1994	8064641	No
1269	1415	1415.0	41.08	41.1	P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation.	Berk Hess	J Chem Theory Comput	2008	26619985	Yes
1270	1413	1413.0	66.6	66.6	Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury.	D R Janero	Free Radic Biol Med	1990	2079232	No
1271	4238	1412.7	113.83	37.9	Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm.	Prateek Kumar, Steven Henikoff, Pauline C Ng	Nat Protoc	2009	19561590	Yes
1272	2823	1411.5	71.85	35.9	Protein structure comparison by alignment of distance matrices.	L Holm, C Sander	J Mol Biol	1993	8377180	Yes
1273	2822	1411.0	87.3	43.6	Cloned glutamate receptors.	M Hollmann, S Heinemann	Annu Rev Neurosci	1994	8210177	No
1274	1411	1411.0	28.81	28.8	The microRNA Registry.	Sam Griffiths-Jones	Nucleic Acids Res	2004	14681370	Yes
1275	2822	1411.0	106.16	53.1	Macrophage plasticity and polarization: in vivo veritas.	Antonio Sica, Alberto Mantovani	J Clin Invest	2012	22378047	No
1276	1410	1410.0	58.89	58.9	Drugs of abuse: anatomy, pharmacology and function of reward pathways.	G F Koob	Trends Pharmacol Sci	1992	1604710	No
1277	1410	1410.0	45.26	45.3	Porous scaffold design for tissue engineering.	Scott J Hollister	Nat Mater	2005	16003400	No
1278	1409	1409.0	36.68	36.7	Getting formal with dopamine and reward.	Wolfram Schultz	Neuron	2002	12383780	No
1279	1408	1408.0	0.0	0.0	Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma.	A Breslow	Ann Surg	1970	5477666	Yes
1280	1408	1408.0	31.9	31.9	Points of control in inflammation.	Carl Nathan	Nature	2002	12490957	No
1281	4218	1406.0	121.63	40.5	Median-joining networks for inferring intraspecific phylogenies.	H J Bandelt, P Forster, A Röhl	Mol Biol Evol	1999	10331250	Yes
1282	1406	1406.0	45.91	45.9	Perceptual symbol systems.	L W Barsalou	Behav Brain Sci	1999	11301525	No
1283	1405	1405.0	0.0	0.0	High-speed scanning in human memory.	S Sternberg	Science	1966	5939936	Yes
1284	1405	1405.0	37.17	37.2	Growth of the plant cell wall.	Daniel J Cosgrove	Nat Rev Mol Cell Biol	2005	16261190	No
1285	1404	1404.0	43.33	43.3	Oxidative stress and neurodegeneration: where are we now?	Barry Halliwell	J Neurochem	2006	16805774	No
1286	9824	1403.4	280.96	40.1	Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.	William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan	N Engl J Med	2002	11832527	Yes
1287	2806	1403.0	116.77	58.4	ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts.	M Gardes, T D Bruns	Mol Ecol	1993	8180733	Yes
1288	2803	1401.5	76.98	38.5	A scaling normalization method for differential expression analysis of RNA-seq data.	Mark D Robinson, Alicia Oshlack	Genome Biol	2010	20196867	Yes
1289	1400	1400.0	38.16	38.2	Tricine-SDS-PAGE.	Hermann Schägger	Nat Protoc	2006	17406207	Yes
1290	1400	1400.0	36.65	36.6	Tumor angiogenesis.	Robert S Kerbel	N Engl J Med	2008	18463380	No
1291	4197	1399.0	112.9	37.6	Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons.	A Nicholls, K A Sharp, B Honig	Proteins	1991	1758883	Yes
1292	1399	1399.0	0.0	0.0	Evolutionary rate at the molecular level.	M Kimura	Nature	1968	5637732	Yes
1293	1398	1398.0	37.88	37.9	Cellular basis of working memory.	P S Goldman-Rakic	Neuron	1995	7695894	No
1294	1398	1398.0	42.98	43.0	Molecular dissection of reactive astrogliosis and glial scar formation.	Michael V Sofroniew	Trends Neurosci	2009	19782411	No
1295	2793	1396.5	84.52	42.3	Dali server: conservation mapping in 3D.	Liisa Holm, Päivi Rosenström	Nucleic Acids Res	2010	20457744	Yes
1296	1396	1396.0	42.74	42.7	What we can do and what we cannot do with fMRI.	Nikos K Logothetis	Nature	2008	18548064	No
1297	1396	1396.0	45.09	45.1	Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.	Ralph A Defronzo	Diabetes	2009	19336687	No
1298	1395	1395.0	69.12	69.1	Perception of risk.	P Slovic	Science	1987	3563507	Yes
1299	1395	1395.0	47.75	47.8	Flavonoids as antioxidants.	P G Pietta	J Nat Prod	2000	10924197	No
1300	11157	1394.6	307.87	38.5	Electric field effect in atomically thin carbon films.	K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A Firsov	Science	2004	15499015	Yes
1301	1394	1394.0	39.3	39.3	Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations.	M J Meaney	Annu Rev Neurosci	2001	11520931	No
1302	1393	1393.0	38.8	38.8	Effects of cytochalasin and phalloidin on actin.	J A Cooper	J Cell Biol	1987	3312229	No
1303	1392	1392.0	52.45	52.5	The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions.	B L Fredrickson	Am Psychol	2001	11315248	Yes
1304	2783	1391.5	89.4	44.7	Event-related EEG/MEG synchronization and desynchronization: basic principles.	G Pfurtscheller, F H Lopes da Silva	Clin Neurophysiol	1999	10576479	No
1305	4174	1391.3	127.38	42.5	Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.	Z N Oltvai, C L Milliman, S J Korsmeyer	Cell	1993	8358790	Yes
1306	1391	1391.0	33.9	33.9	PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms.	Michael F. Thomashow	Annu Rev Plant Physiol Plant Mol Biol	1999	15012220	Yes
1307	2781	1390.5	73.42	36.7	The BCL-2 protein family: opposing activities that mediate cell death.	Richard J Youle, Andreas Strasser	Nat Rev Mol Cell Biol	2008	18097445	No
1308	6951	1390.2	164.59	32.9	Stages of embryonic development of the zebrafish.	C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F Schilling	Dev Dyn	1995	8589427	Yes
1309	2780	1390.0	69.69	34.8	The DNA-damage response in human biology and disease.	Stephen P Jackson, Jiri Bartek	Nature	2009	19847258	No
1310	1390	1390.0	34.08	34.1	The hippo signaling pathway in development and cancer.	Duojia Pan	Dev Cell	2010	20951342	No
1311	2779	1389.5	60.12	30.1	Upstream and downstream of mTOR.	Nissim Hay, Nahum Sonenberg	Genes Dev	2004	15314020	No
1312	5557	1389.2	0.0	0.0	Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.	D J Sahn, A DeMaria, J Kisslo, A Weyman	Circulation	1978	709763	Yes
1313	1389	1389.0	33.52	33.5	The caveolae membrane system.	R G Anderson	Annu Rev Biochem	1998	9759488	No
1314	1389	1389.0	28.24	28.2	Switching and signaling at the telomere.	E H Blackburn	Cell	2001	11572773	No
1315	15279	1389.0	425.71	38.7	PLINK: a tool set for whole-genome association and population-based linkage analyses.	Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C Sham	Am J Hum Genet	2007	17701901	Yes
1316	1388	1388.0	29.67	29.7	Hox genes in vertebrate development.	R Krumlauf	Cell	1994	7913880	No
1317	1388	1388.0	52.65	52.6	The stress response in fish.	S E Wendelaar Bonga	Physiol Rev	1997	9234959	No
1318	1386	1386.0	0.0	0.0	The Gingival Index, the Plaque Index and the Retention Index Systems.	H Löe	J Periodontol	1967	5237684	Yes
1319	1386	1386.0	79.46	79.5	Role of endothelium in responses of vascular smooth muscle.	R F Furchgott	Circ Res	1983	6313250	No
1320	1386	1386.0	39.76	39.8	Adipose tissue, adipokines, and inflammation.	Giamila Fantuzzi	J Allergy Clin Immunol	2005	15867843	No
1321	2770	1385.0	62.89	31.4	Signaling to NF-kappaB.	Matthew S Hayden, Sankar Ghosh	Genes Dev	2004	15371334	No
1322	1384	1384.0	57.47	57.5	Glutamate: a neurotransmitter in mammalian brain.	F Fonnum	J Neurochem	1984	6139418	No
1323	4151	1383.7	109.02	36.3	Inflammation and atherosclerosis.	Peter Libby, Paul M Ridker, Attilio Maseri	Circulation	2002	11877368	No
1324	1383	1383.0	0.0	0.0	EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. IV. DISTRIBUTION OF MONOAMINE NERVE TERMINALS IN THE CENTRAL NERVOUS SYSTEM.	K FUXE	Acta Physiol Scand Suppl	1965	14319769	Yes
1325	1382	1382.0	35.05	35.0	DNA topoisomerases.	J C Wang	Annu Rev Biochem	1996	8811192	No
1326	1381	1381.0	0.0	0.0	Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals.	J N Dumont	J Morphol	1972	4109871	Yes
1327	1381	1381.0	44.86	44.9	The basal ganglia: focused selection and inhibition of competing motor programs.	J W Mink	Prog Neurobiol	1996	9004351	No
1328	2762	1381.0	88.07	44.0	Autophagy: renovation of cells and tissues.	Noboru Mizushima, Masaaki Komatsu	Cell	2011	22078875	No
1329	1380	1380.0	47.6	47.6	The in vitro micronucleus technique.	M Fenech	Mutat Res	2000	11113469	No
1330	1380	1380.0	23.96	24.0	Neuronal specification in the spinal cord: inductive signals and transcriptional codes.	T M Jessell	Nat Rev Genet	2000	11262869	No
1331	8278	1379.7	177.83	29.6	Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.	A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C Mello	Nature	1998	9486653	Yes
1332	2759	1379.5	108.9	54.5	Palladium-catalyzed ligand-directed C-H functionalization reactions.	Thomas W Lyons, Melanie S Sanford	Chem Rev	2010	20078038	No
1333	2758	1379.0	0.0	0.0	Maturation of the head of bacteriophage T4. I. DNA packaging events.	U K Laemmli, M Favre	J Mol Biol	1973	4204102	Yes
1334	2757	1378.5	94.35	47.2	Inositol phosphates and cell signalling.	M J Berridge, R F Irvine	Nature	1989	2550825	No
1335	1378	1378.0	47.34	47.3	Multiple imputation: a primer.	J L Schafer	Stat Methods Med Res	1999	10347857	No
1336	1377	1377.0	0.0	0.0	Mode of cell migration to the superficial layers of fetal monkey neocortex.	P Rakic	J Comp Neurol	1972	4624784	Yes
1337	1377	1377.0	37.03	37.0	Python: a programming language for software integration and development.	M F Sanner	J Mol Graph Model	1999	10660911	Yes
1338	1377	1377.0	33.46	33.5	Trastuzumab--mechanism of action and use in clinical practice.	Clifford A Hudis	N Engl J Med	2007	17611206	No
1339	1376	1376.0	40.04	40.0	Dengue and dengue hemorrhagic fever.	D J Gubler	Clin Microbiol Rev	1998	9665979	No
1340	1375	1375.0	52.23	52.2	Interleukin-1 and interleukin-1 antagonism.	C A Dinarello	Blood	1991	1826616	No
1341	1375	1375.0	26.45	26.4	Cyclin-dependent kinases: engines, clocks, and microprocessors.	D O Morgan	Annu Rev Cell Dev Biol	1997	9442875	No
1342	1375	1375.0	28.35	28.4	Neuroblastoma: biological insights into a clinical enigma.	Garrett M Brodeur	Nat Rev Cancer	2003	12612655	No
1343	4123	1374.3	177.63	59.2	Effect of the damping function in dispersion corrected density functional theory.	Stefan Grimme, Stephan Ehrlich, Lars Goerigk	J Comput Chem	2011	21370243	Yes
1344	5497	1374.2	278.98	69.7	jModelTest 2: more models, new heuristics and parallel computing.	Diego Darriba, Guillermo L Taboada, Ramón Doallo, David Posada	Nat Methods	2012	22847109	Yes
1345	2748	1374.0	75.2	37.6	The Fas death factor.	S Nagata, P Golstein	Science	1995	7533326	No
1346	1373	1373.0	43.91	43.9	Determination of minimum inhibitory concentrations.	J M Andrews	J Antimicrob Chemother	2001	11420333	Yes
1347	1372	1372.0	46.85	46.9	New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures.	R Y Tsien	Biochemistry	1980	6770893	Yes
1348	4116	1372.0	214.17	71.4	The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs.	C A McHorney, J E Ware, A E Raczek	Med Care	1993	8450681	Yes
1349	2741	1370.5	64.98	32.5	Fibroblasts in cancer.	Raghu Kalluri, Michael Zeisberg	Nat Rev Cancer	2006	16572188	No
1350	5470	1367.5	115.72	28.9	A comparison of normalization methods for high density oligonucleotide array data based on variance and bias.	B M Bolstad, R A Irizarry, M Astrand, T P Speed	Bioinformatics	2003	12538238	Yes
1351	2735	1367.5	70.07	35.0	Human mesenchymal stem cells modulate allogeneic immune cell responses.	Sudeepta Aggarwal, Mark F Pittenger	Blood	2005	15494428	Yes
1352	2735	1367.5	95.61	47.8	Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference.	Stephen M Smith, Thomas E Nichols	Neuroimage	2009	18501637	Yes
1353	1367	1367.0	30.61	30.6	Neurotrophins and their receptors: a convergence point for many signalling pathways.	Moses V Chao	Nat Rev Neurosci	2003	12671646	No
1354	4099	1366.3	86.28	28.8	T-Coffee: A novel method for fast and accurate multiple sequence alignment.	C Notredame, D G Higgins, J Heringa	J Mol Biol	2000	10964570	Yes
1355	1366	1366.0	39.58	39.6	From sensation to cognition.	M M Mesulam	Brain	1998	9648540	No
1356	1366	1366.0	50.06	50.1	Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges.	Leonardo Pantoni	Lancet Neurol	2010	20610345	No
1357	2725	1362.5	69.51	34.8	Shared principles in NF-kappaB signaling.	Matthew S Hayden, Sankar Ghosh	Cell	2008	18267068	No
1358	4087	1362.3	125.15	41.7	The metabolic syndrome--a new worldwide definition.	K George M M Alberti, Paul Zimmet, Jonathan Shaw	Lancet	2005	16182882	Yes
1359	1362	1362.0	35.66	35.7	Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome.	B L Wajchenberg	Endocr Rev	2000	11133069	No
1360	1362	1362.0	0.0	0.0	A METHOD OF MEASURING EYE MOVEMENT USING A SCLERAL SEARCH COIL IN A MAGNETIC FIELD.	D A ROBINSON	IEEE Trans Biomed Eng	1963	14121113	Yes
1361	2723	1361.5	0.0	0.0	EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.	A DAHLSTROEM, K FUXE	Acta Physiol Scand Suppl	1964	14229500	Yes
1362	4083	1361.0	118.24	39.4	Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey.	Earl S Ford, Wayne H Giles, William H Dietz	JAMA	2002	11790215	Yes
1363	2721	1360.5	206.9	103.5	A clinical method of functional assessment of the shoulder.	C R Constant, A H Murley	Clin Orthop Relat Res	1987	3791738	Yes
1364	2718	1359.0	62.28	31.1	Why do cancers have high aerobic glycolysis?	Robert A Gatenby, Robert J Gillies	Nat Rev Cancer	2004	15516961	No
1365	1358	1358.0	36.32	36.3	Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods.	Z Yang	J Mol Evol	1994	7932792	Yes
1366	1358	1358.0	50.89	50.9	Constructions of masculinity and their influence on men's well-being: a theory of gender and health.	W H Courtenay	Soc Sci Med	2000	10741575	No
1367	1357	1357.0	24.59	24.6	Cell cycle checkpoint signaling through the ATM and ATR kinases.	R T Abraham	Genes Dev	2001	11544175	No
1368	2713	1356.5	80.85	40.4	Protein folding in the cell.	M J Gething, J Sambrook	Nature	1992	1731198	No
1369	2712	1356.0	54.24	27.1	Cellular motility driven by assembly and disassembly of actin filaments.	Thomas D Pollard, Gary G Borisy	Cell	2003	12600310	No
1370	2712	1356.0	0.0	0.0	Plaque formation and isolation of pure lines with poliomyelitis viruses.	R DULBECCO, M VOGT	J Exp Med	1954	13130792	Yes
1371	8127	1354.5	277.78	46.3	Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication.	Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E Walters	Arch Gen Psychiatry	2005	15939837	Yes
1372	2709	1354.5	107.79	53.9	Microenvironmental regulation of tumor progression and metastasis.	Daniela F Quail, Johanna A Joyce	Nat Med	2013	24202395	No
1373	1354	1354.0	35.57	35.6	A revolution in optical manipulation.	David G Grier	Nature	2003	12917694	No
1374	1353	1353.0	0.0	0.0	The micronucleus test.	W Schmid	Mutat Res	1975	48190	Yes
1375	1353	1353.0	75.78	75.8	Determinants of low birth weight: methodological assessment and meta-analysis.	M S Kramer	Bull World Health Organ	1987	3322602	No
1376	1353	1353.0	43.04	43.0	Cell biology and molecular basis of denitrification.	W G Zumft	Microbiol Mol Biol Rev	1997	9409151	No
1377	1353	1353.0	30.45	30.4	Oxidative stress shortens telomeres.	Thomas von Zglinicki	Trends Biochem Sci	2002	12114022	Yes
1378	2705	1352.5	58.2	29.1	Automated MAD and MIR structure solution.	T C Terwilliger, J Berendzen	Acta Crystallogr D Biol Crystallogr	1999	10089316	Yes
1379	2705	1352.5	106.83	53.4	Shifting the genomic gold standard for the prokaryotic species definition.	Michael Richter, Ramon Rosselló-Móra	Proc Natl Acad Sci U S A	2009	19855009	Yes
1380	1352	1352.0	0.0	0.0	A modified card sorting test sensitive to frontal lobe defects.	H E Nelson	Cortex	1976	1009768	Yes
1381	1352	1352.0	81.38	81.4	Brain dopamine receptors.	P Seeman	Pharmacol Rev	1980	6117090	No
1382	2702	1351.0	71.0	35.5	A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids.	D Wessel, U I Flügge	Anal Biochem	1984	6731838	Yes
1383	1351	1351.0	32.34	32.3	An extensively modified version of MolScript that includes greatly enhanced coloring capabilities.	R M Esnouf	J Mol Graph Model	1997	9385560	Yes
1384	1350	1350.0	0.0	0.0	Pedigrees of some mutant strains of Escherichia coli K-12.	B J Bachmann	Bacteriol Rev	1972	4568763	No
1385	1349	1349.0	27.34	27.3	How cells read TGF-beta signals.	J Massagué	Nat Rev Mol Cell Biol	2000	11252892	No
1386	13481	1348.1	527.02	52.7	The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.	F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S Luthra	Arthritis Rheum	1988	3358796	Yes
1387	1348	1348.0	71.24	71.2	The drug abuse screening test.	H A Skinner	Addict Behav	1982	7183189	Yes
1388	1348	1348.0	0.0	0.0	POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES.	D E Goldman	J Gen Physiol	1943	19873371	Yes
1389	1347	1347.0	0.0	0.0	Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.	E M Witkin	Bacteriol Rev	1976	795416	No
1390	2694	1347.0	127.71	63.9	The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger.	A J Stunkard, S Messick	J Psychosom Res	1985	3981480	Yes
1391	1347	1347.0	57.97	58.0	A cortical network for directed attention and unilateral neglect.	M M Mesulam	Ann Neurol	1981	7032417	No
1392	4041	1347.0	114.94	38.3	A neural substrate of prediction and reward.	W Schultz, P Dayan, P R Montague	Science	1997	9054347	No
1393	1347	1347.0	43.71	43.7	Trail Making Test A and B: normative data stratified by age and education.	Tom N Tombaugh	Arch Clin Neuropsychol	2004	15010086	Yes
1394	2693	1346.5	93.23	46.6	Molecular mechanisms and clinical applications of angiogenesis.	Peter Carmeliet, Rakesh K Jain	Nature	2011	21593862	No
1395	1346	1346.0	0.0	0.0	Areas, volumes, packing and protein structure.	F M Richards	Annu Rev Biophys Bioeng	1977	326146	No
1396	4038	1346.0	78.94	26.3	Notch signaling: cell fate control and signal integration in development.	S Artavanis-Tsakonas, M D Rand, R J Lake	Science	1999	10221902	No
1397	1345	1345.0	0.0	0.0	Simple memory: a theory for archicortex.	D Marr	Philos Trans R Soc Lond B Biol Sci	1971	4399412	Yes
1398	1345	1345.0	70.61	70.6	Interleukin-1.	C A Dinarello	Rev Infect Dis	1984	6369481	No
1399	2690	1345.0	63.61	31.8	Complex networks orchestrate epithelial-mesenchymal transitions.	Jean Paul Thiery, Jonathan P Sleeman	Nat Rev Mol Cell Biol	2006	16493418	No
1400	1345	1345.0	33.51	33.5	Introduction to NF-kappaB: players, pathways, perspectives.	T D Gilmore	Oncogene	2006	17072321	No
1401	2689	1344.5	80.34	40.2	Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.	P J Southern, P Berg	J Mol Appl Genet	1982	6286831	Yes
1402	2689	1344.5	133.03	66.5	Assays of glutathione peroxidase.	L Flohé, W A Günzler	Methods Enzymol	1984	6727659	Yes
1403	1344	1344.0	54.27	54.3	Large-scale neurocognitive networks and distributed processing for attention, language, and memory.	M M Mesulam	Ann Neurol	1990	2260847	No
1404	1344	1344.0	42.42	42.4	Leptospirosis.	P N Levett	Clin Microbiol Rev	2001	11292640	No
1405	2687	1343.5	60.85	30.4	Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases.	Gary L Johnson, Razvan Lapadat	Science	2002	12471242	No
1406	4030	1343.3	92.22	30.7	Efficient selection for high-expression transfectants with a novel eukaryotic vector.	H Niwa, K Yamamura, J Miyazaki	Gene	1991	1660837	Yes
1407	2686	1343.0	106.22	53.1	Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability.	F Denizot, R Lang	J Immunol Methods	1986	3486233	Yes
1408	2686	1343.0	57.86	28.9	Fitting a mixture model by expectation maximization to discover motifs in biopolymers.	T L Bailey, C Elkan	Proc Int Conf Intell Syst Mol Biol	1994	7584402	Yes
1409	1342	1342.0	0.0	0.0	Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids.	D AMINOFF	Biochem J	1961	13860975	Yes
1410	1342	1342.0	32.0	32.0	Perceptions of epigenetics.	Adrian Bird	Nature	2007	17522671	Yes
1411	2683	1341.5	0.0	0.0	A fluorometric method for determination of oxidized and reduced glutathione in tissues.	P J Hissin, R Hilf	Anal Biochem	1976	962076	Yes
1412	1340	1340.0	53.16	53.2	Intracellular calcium homeostasis.	E Carafoli	Annu Rev Biochem	1987	3304139	No
1413	13395	1339.5	549.23	54.9	Measurement of protein using bicinchoninic acid.	P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C Klenk	Anal Biochem	1985	3843705	Yes
1414	1339	1339.0	37.48	37.5	Structural design and molecular evolution of a cytokine receptor superfamily.	J F Bazan	Proc Natl Acad Sci U S A	1990	2169613	Yes
1415	5354	1338.5	169.43	42.4	Functional connectivity in the motor cortex of resting human brain using echo-planar MRI.	B Biswal, F Z Yetkin, V M Haughton, J S Hyde	Magn Reson Med	1995	8524021	Yes
1416	2677	1338.5	58.62	29.3	NF-kappaB regulation in the immune system.	Qiutang Li, Inder M Verma	Nat Rev Immunol	2002	12360211	No
1417	4013	1337.7	95.39	31.8	An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database.	J K Eng, A L McCormack, J R Yates	J Am Soc Mass Spectrom	1994	24226387	Yes
1418	6687	1337.4	179.42	35.9	Development and testing of a general amber force field.	Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A Case	J Comput Chem	2004	15116359	Yes
1419	1337	1337.0	38.03	38.0	Recognition of errors in three-dimensional structures of proteins.	M J Sippl	Proteins	1993	8108378	Yes
1420	1337	1337.0	31.59	31.6	An approximately unbiased test of phylogenetic tree selection.	Hidetoshi Shimodaira	Syst Biol	2002	12079646	Yes
1421	2673	1336.5	0.0	0.0	Receptive fields and functional architecture of monkey striate cortex.	D H Hubel, T N Wiesel	J Physiol	1968	4966457	Yes
1422	1336	1336.0	53.38	53.4	Pineal melatonin: cell biology of its synthesis and of its physiological interactions.	R J Reiter	Endocr Rev	1991	1649044	No
1423	1336	1336.0	49.1	49.1	Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events?	George A Bonanno	Am Psychol	2004	14736317	No
1424	6680	1336.0	190.9	38.2	Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.	Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan Hsu	N Engl J Med	2004	15385656	Yes
1425	1335	1335.0	58.66	58.7	The linear-quadratic formula and progress in fractionated radiotherapy.	J F Fowler	Br J Radiol	1989	2670032	No
1426	1335	1335.0	0.0	0.0	Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system.	D M Neville	J Biol Chem	1971	5127429	Yes
1427	2667	1333.5	61.16	30.6	Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions.	E Krissinel, K Henrick	Acta Crystallogr D Biol Crystallogr	2004	15572779	Yes
1428	1333	1333.0	33.8	33.8	Mammalian G1 cyclins.	C J Sherr	Cell	1993	8513492	No
1429	1333	1333.0	28.37	28.4	Cell cycle checkpoints: preventing an identity crisis.	S J Elledge	Science	1996	8939848	No
1430	1331	1331.0	0.0	0.0	Chromatin structure: a repeating unit of histones and DNA.	R D Kornberg	Science	1974	4825889	Yes
1431	2662	1331.0	56.62	28.3	Missing pieces in the NF-kappaB puzzle.	Sankar Ghosh, Michael Karin	Cell	2002	11983155	No
1432	1331	1331.0	40.01	40.0	Task switching.	Stephen Monsell	Trends Cogn Sci	2003	12639695	Yes
1433	1330	1330.0	72.47	72.5	Adverse health effects of high-effort/low-reward conditions.	J Siegrist	J Occup Health Psychol	1996	9547031	No
1434	1330	1330.0	37.39	37.4	Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia.	Shitij Kapur	Am J Psychiatry	2003	12505794	No
1435	2660	1330.0	72.3	36.1	Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry.	Robert Visse, Hideaki Nagase	Circ Res	2003	12730128	No
1436	3988	1329.3	153.42	51.1	Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.	H Esterbauer, R J Schaur, H Zollner	Free Radic Biol Med	1991	1937131	No
1437	2658	1329.0	109.12	54.6	Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease.	R A DeFronzo, E Ferrannini	Diabetes Care	1991	2044434	No
1438	1328	1328.0	0.0	0.0	The relationship between the spleen colony-forming cell and the haemopoietic stem cell.	R Schofield	Blood Cells	1978	747780	Yes
1439	1328	1328.0	32.03	32.0	From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.	W A Catterall	Neuron	2000	10798388	No
1440	2656	1328.0	83.57	41.8	The precuneus: a review of its functional anatomy and behavioural correlates.	Andrea E Cavanna, Michael R Trimble	Brain	2006	16399806	No
1441	1327	1327.0	0.0	0.0	Stereological principles for morphometry in electron microscopic cytology.	E R Weibel	Int Rev Cytol	1969	4899604	No
1442	1327	1327.0	58.36	58.4	Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?	B Halliwell	Lancet	1994	7915779	No
1443	1327	1327.0	27.3	27.3	Protein degradation and protection against misfolded or damaged proteins.	Alfred L Goldberg	Nature	2003	14685250	No
1444	1326	1326.0	43.05	43.0	Oxidative stress: oxidants and antioxidants.	H Sies	Exp Physiol	1997	9129943	No
1445	1326	1326.0	62.0	62.0	Antibiotics in the aquatic environment--a review--part I.	Klaus Kümmerer	Chemosphere	2009	19185900	No
1446	1325	1325.0	58.45	58.5	Intermediate filaments as mechanical integrators of cellular space.	E Lazarides	Nature	1980	7188712	Yes
1447	1325	1325.0	34.5	34.5	Hypertrophic cardiomyopathy: a systematic review.	Barry J Maron	JAMA	2002	11886323	No
1448	2650	1325.0	0.0	0.0	Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature.	J MARMUR, P DOTY	J Mol Biol	1962	14470099	Yes
1449	1325	1325.0	34.63	34.6	Thiazolidinediones.	Hannele Yki-Järvinen	N Engl J Med	2004	15356308	No
1450	5297	1324.2	145.04	36.3	Improved optimization for the robust and accurate linear registration and motion correction of brain images.	Mark Jenkinson, Peter Bannister, Michael Brady, Stephen Smith	Neuroimage	2002	12377157	Yes
1451	2648	1324.0	0.0	0.0	Polymyositis and dermatomyositis (first of two parts).	A Bohan, J B Peter	N Engl J Med	1975	1090839	No
1452	1324	1324.0	32.14	32.1	Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1.	G L Semenza	Annu Rev Cell Dev Biol	1999	10611972	No
1453	1324	1324.0	54.17	54.2	Large-scale brain networks and psychopathology: a unifying triple network model.	Vinod Menon	Trends Cogn Sci	2011	21908230	No
1454	2647	1323.5	58.01	29.0	Toll-like receptor control of the adaptive immune responses.	Akiko Iwasaki, Ruslan Medzhitov	Nat Immunol	2004	15454922	No
1455	2646	1323.0	100.34	50.2	Separate visual pathways for perception and action.	M A Goodale, A D Milner	Trends Neurosci	1992	1374953	No
1456	2645	1322.5	117.5	58.8	Pain assessment: global use of the Brief Pain Inventory.	C S Cleeland, K M Ryan	Ann Acad Med Singap	1994	8080219	No
1457	3967	1322.3	139.48	46.5	Atrial fibrillation as an independent risk factor for stroke: the Framingham Study.	P A Wolf, R D Abbott, W B Kannel	Stroke	1991	1866765	Yes
1458	1322	1322.0	37.99	38.0	The corticosteroid receptor hypothesis of depression.	F Holsboer	Neuropsychopharmacology	2000	11027914	No
1459	3966	1322.0	103.49	34.5	Click Chemistry: Diverse Chemical Function from a Few Good Reactions.	Hartmuth C. Kolb, M. G. Finn, K. Barry Sharpless	Angew Chem Int Ed Engl	2001	11433435	Yes
1460	1321	1321.0	0.0	0.0	Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay.	B E Murphy	J Clin Endocrinol Metab	1967	4291524	Yes
1461	2640	1320.0	90.18	45.1	Alzheimer's disease.	Henry W Querfurth, Frank M LaFerla	N Engl J Med	2010	20107219	No
1462	1319	1319.0	51.55	51.5	Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.	M Zasloff	Proc Natl Acad Sci U S A	1987	3299384	Yes
1463	1319	1319.0	0.0	0.0	Cerebral vascular accidents in patients over the age of 60. II. Prognosis.	J RANKIN	Scott Med J	1957	13432835	Yes
1464	1319	1319.0	27.57	27.6	Immunosuppressive networks in the tumour environment and their therapeutic relevance.	Weiping Zou	Nat Rev Cancer	2005	15776005	No
1465	1318	1318.0	40.93	40.9	Oxidative stress hypothesis in Alzheimer's disease.	W R Markesbery	Free Radic Biol Med	1997	9165306	No
1466	2635	1317.5	90.65	45.3	Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI.	P J Basser, C Pierpaoli	J Magn Reson B	1996	8661285	Yes
1467	1317	1317.0	51.23	51.2	Health consequences of obesity in youth: childhood predictors of adult disease.	W H Dietz	Pediatrics	1998	12224658	No
1468	13165	1316.5	351.23	35.1	Multilineage potential of adult human mesenchymal stem cells.	M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R Marshak	Science	1999	10102814	Yes
1469	2633	1316.5	54.69	27.3	Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.	O Tetsu, F McCormick	Nature	1999	10201372	Yes
1470	1316	1316.0	27.53	27.5	Intrinsically unstructured proteins.	Peter Tompa	Trends Biochem Sci	2002	12368089	No
1471	1315	1315.0	26.12	26.1	Vienna RNA secondary structure server.	Ivo L Hofacker	Nucleic Acids Res	2003	12824340	Yes
1472	2629	1314.5	62.94	31.5	Cell migration: a physically integrated molecular process.	D A Lauffenburger, A F Horwitz	Cell	1996	8608589	No
1473	7884	1314.0	261.29	43.5	Positional cloning of the mouse obese gene and its human homologue.	Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M Friedman	Nature	1994	7984236	Yes
1474	5255	1313.8	247.15	61.8	16S ribosomal DNA amplification for phylogenetic study.	W G Weisburg, S M Barns, D A Pelletier, D J Lane	J Bacteriol	1991	1987160	Yes
1475	1313	1313.0	35.9	35.9	The biology of incretin hormones.	Daniel J Drucker	Cell Metab	2006	16517403	No
1476	2625	1312.5	75.59	37.8	Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation.	M A Nitsche, W Paulus	J Physiol	2000	10990547	Yes
1477	1312	1312.0	34.73	34.7	In vivo near-infrared fluorescence imaging.	John V Frangioni	Curr Opin Chem Biol	2003	14580568	No
1478	1311	1311.0	26.89	26.9	Germinal centers.	I C MacLennan	Annu Rev Immunol	1994	8011279	No
1479	1311	1311.0	27.29	27.3	Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing.	D I Svergun	Biophys J	1999	10354416	Yes
1480	2622	1311.0	78.62	39.3	Multiple sclerosis.	Alastair Compston, Alasdair Coles	Lancet	2008	18970977	Yes
1481	2621	1310.5	52.25	26.1	The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.	Michael H Glickman, Aaron Ciechanover	Physiol Rev	2002	11917093	No
1482	1309	1309.0	46.83	46.8	Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy.	Y Ben-Ari	Neuroscience	1985	2859548	No
1483	5233	1308.2	122.25	30.6	MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform.	Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi Miyata	Nucleic Acids Res	2002	12136088	Yes
1484	2613	1306.5	101.03	50.5	Neurocircuitry of addiction.	George F Koob, Nora D Volkow	Neuropsychopharmacology	2010	19710631	No
1485	3919	1306.3	95.94	32.0	Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.	J E Darnell, I M Kerr, G R Stark	Science	1994	8197455	No
1486	1306	1306.0	0.0	0.0	Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study.	E G GRAY	J Anat	1959	13829103	Yes
1487	1305	1305.0	0.0	0.0	Statistical analysis of enzyme kinetic data.	W W Cleland	Methods Enzymol	1979	502857	Yes
1488	2610	1305.0	0.0	0.0	New method for quantitative determination of uronic acids.	N Blumenkrantz, G Asboe-Hansen	Anal Biochem	1973	4269305	Yes
1489	2609	1304.5	96.71	48.4	Unified approach for molecular dynamics and density-functional theory.	Car, Parrinello	Phys Rev Lett	1985	10032153	Yes
1490	1304	1304.0	44.83	44.8	A computational procedure for determining energetically favorable binding sites on biologically important macromolecules.	P J Goodford	J Med Chem	1985	3892003	Yes
1491	1304	1304.0	0.0	0.0	Selforganization of matter and the evolution of biological macromolecules.	M Eigen	Naturwissenschaften	1971	4942363	No
1492	1304	1304.0	28.14	28.1	Regulatory T cells, tumour immunity and immunotherapy.	Weiping Zou	Nat Rev Immunol	2006	16557261	No
1493	7820	1303.3	278.77	46.5	Cancer statistics, 2009.	Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J Thun	CA Cancer J Clin	2009	19474385	Yes
1494	1301	1301.0	33.31	33.3	Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone.	M B Luskin	Neuron	1993	8338665	Yes
1495	1301	1301.0	31.78	31.8	Far-field optical nanoscopy.	Stefan W Hell	Science	2007	17525330	No
1496	5202	1300.5	168.63	42.2	Comorbidity measures for use with administrative data.	A Elixhauser, C Steiner, D R Harris, R M Coffey	Med Care	1998	9431328	Yes
1497	1300	1300.0	33.53	33.5	Pathogenesis of group A streptococcal infections.	M W Cunningham	Clin Microbiol Rev	2000	10885988	No
1498	1299	1299.0	48.03	48.0	The role of the amygdala in fear and anxiety.	M Davis	Annu Rev Neurosci	1992	1575447	No
1499	1299	1299.0	39.43	39.4	Solvent-accessible surfaces of proteins and nucleic acids.	M L Connolly	Science	1983	6879170	Yes
1500	1299	1299.0	34.38	34.4	Insulin and insulin-like growth factor signalling in neoplasia.	Michael Pollak	Nat Rev Cancer	2008	19029956	No
1501	1299	1299.0	36.89	36.9	Pathogen recognition and inflammatory signaling in innate immune defenses.	Trine H Mogensen	Clin Microbiol Rev	2009	19366914	No
1502	1298	1298.0	46.58	46.6	Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.	G C Walker	Microbiol Rev	1984	6371470	No
1503	1298	1298.0	27.27	27.3	RNA silencing in plants.	David Baulcombe	Nature	2004	15372043	No
1504	1297	1297.0	47.72	47.7	The atom economy--a search for synthetic efficiency.	B M Trost	Science	1991	1962206	Yes
1505	1297	1297.0	35.74	35.7	An economic method for the fluorescent labeling of PCR fragments.	M Schuelke	Nat Biotechnol	2000	10657137	Yes
1506	1296	1296.0	49.82	49.8	A new automated colorimetric method for measuring total oxidant status.	Ozcan Erel	Clin Biochem	2005	16214125	Yes
1507	2590	1295.0	132.88	66.4	A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity.	J G Snodgrass, M Vanderwart	J Exp Psychol Hum Learn	1980	7373248	Yes
1508	1295	1295.0	43.59	43.6	The complete general secretory pathway in gram-negative bacteria.	A P Pugsley	Microbiol Rev	1993	8096622	No
1509	2590	1295.0	67.0	33.5	The incidence of congenital heart disease.	Julien I E Hoffman, Samuel Kaplan	J Am Coll Cardiol	2002	12084585	No
1510	1295	1295.0	0.0	0.0	ENZYMATIC BASIS FOR ACTIVE TRANSPORT OF NA+ AND K+ ACROSS CELL MEMBRANE.	J C SKOU	Physiol Rev	1965	14337569	No
1511	1295	1295.0	28.3	28.3	The Buccaneer software for automated model building. 1. Tracing protein chains.	Kevin Cowtan	Acta Crystallogr D Biol Crystallogr	2006	16929101	Yes
1512	1294	1294.0	31.42	31.4	Mechanisms of bone metastasis.	G David Roodman	N Engl J Med	2004	15084698	No
1513	2587	1293.5	73.28	36.6	Empirical threshold values for quantitative trait mapping.	G A Churchill, R W Doerge	Genetics	1994	7851788	Yes
1514	1293	1293.0	33.51	33.5	Structural features in eukaryotic mRNAs that modulate the initiation of translation.	M Kozak	J Biol Chem	1991	1939050	No
1515	1293	1293.0	32.49	32.5	An analysis of vertebrate mRNA sequences: intimations of translational control.	M Kozak	J Cell Biol	1991	1955461	No
1516	1293	1293.0	52.7	52.7	Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage.	D W Choi	Trends Neurosci	1988	2469166	No
1517	1293	1293.0	0.0	0.0	Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.	U Ungerstedt	Acta Physiol Scand Suppl	1971	4332693	Yes
1518	1293	1293.0	49.74	49.7	Validation of a decisional conflict scale.	A M O'Connor	Med Decis Making	1995	7898294	Yes
1519	1292	1292.0	0.0	0.0	THE ESTIMATION OF PEPSIN, TRYPSIN, PAPAIN, AND CATHEPSIN WITH HEMOGLOBIN.	M L Anson	J Gen Physiol	1938	19873094	Yes
1520	2583	1291.5	0.0	0.0	Determination of malonaldehyde precursor in tissues by thiobarbituric acid test.	M Mihara, M Uchiyama	Anal Biochem	1978	655387	Yes
1521	1291	1291.0	49.65	49.6	Cognitive reserve.	Yaakov Stern	Neuropsychologia	2009	19467352	No
1522	3872	1290.7	112.86	37.6	The rapid generation of mutation data matrices from protein sequences.	D T Jones, W R Taylor, J M Thornton	Comput Appl Biosci	1992	1633570	Yes
1523	2581	1290.5	158.13	79.1	Interrater reliability of a modified Ashworth scale of muscle spasticity.	R W Bohannon, M B Smith	Phys Ther	1987	3809245	Yes
1524	2581	1290.5	112.5	56.2	The transtheoretical model of health behavior change.	J O Prochaska, W F Velicer	Am J Health Promot	1997	10170434	No
1525	2581	1290.5	59.3	29.6	The Ki-67 protein: from the known and the unknown.	T Scholzen, J Gerdes	J Cell Physiol	2000	10653597	No
1526	2580	1290.0	58.78	29.4	Coordination of circadian timing in mammals.	Steven M Reppert, David R Weaver	Nature	2002	12198538	No
1527	1290	1290.0	45.41	45.4	Gold-catalyzed organic reactions.	A Stephen K Hashmi	Chem Rev	2007	17580975	Yes
1528	1289	1289.0	37.6	37.6	Precision mapping of quantitative trait loci.	Z B Zeng	Genetics	1994	8013918	Yes
1529	1288	1288.0	0.0	0.0	Complete nucleotide sequence of the Escherichia coli plasmid pBR322.	J G Sutcliffe	Cold Spring Harb Symp Quant Biol	1979	383387	Yes
1530	1288	1288.0	44.69	44.7	Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements.	James J P Stewart	J Mol Model	2007	17828561	Yes
1531	1288	1288.0	36.71	36.7	Integration, scaling, space-group assignment and post-refinement.	Wolfgang Kabsch	Acta Crystallogr D Biol Crystallogr	2010	20124693	Yes
1532	1287	1287.0	0.0	0.0	In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain.	T R Chen	Exp Cell Res	1977	65285	Yes
1533	1287	1287.0	32.94	32.9	Five rules for the evolution of cooperation.	Martin A Nowak	Science	2006	17158317	No
1534	5145	1286.2	230.56	57.6	Reporting results of cancer treatment.	A B Miller, B Hoogstraten, M Staquet, A Winkler	Cancer	1981	7459811	Yes
1535	1286	1286.0	35.07	35.1	The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.	D M Kingsley	Genes Dev	1994	8299934	No
1536	1285	1285.0	59.2	59.2	Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.	P Holzer	Pharmacol Rev	1991	1852779	No
1537	1285	1285.0	29.82	29.8	Neurotrophins as synaptic modulators.	M M Poo	Nat Rev Neurosci	2001	11253356	No
1538	1284	1284.0	0.0	0.0	Why genes in pieces?	W Gilbert	Nature	1978	622185	Yes
1539	2568	1284.0	0.0	0.0	Variations in the pattern of pubertal changes in boys.	W A Marshall, J M Tanner	Arch Dis Child	1970	5440182	Yes
1540	1284	1284.0	44.02	44.0	Glycobiology: Toward Understanding the Function of Sugars.	Raymond A. Dwek	Chem Rev	1996	11848770	Yes
1541	1284	1284.0	39.32	39.3	The world health report 2002 - reducing risks, promoting healthy life.	J J Guilbert	Educ Health (Abingdon)	2003	14741909	Yes
1542	1283	1283.0	40.98	41.0	n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases.	Philip C Calder	Am J Clin Nutr	2006	16841861	No
1543	1283	1283.0	53.85	53.9	Falls in older people: epidemiology, risk factors and strategies for prevention.	Laurence Z Rubenstein	Age Ageing	2006	16926202	No
1544	6411	1282.2	137.44	27.5	Prospective identification of tumorigenic breast cancer cells.	Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F Clarke	Proc Natl Acad Sci U S A	2003	12629218	Yes
1545	1282	1282.0	34.59	34.6	A cell culture model for T lymphocyte clonal anergy.	R H Schwartz	Science	1990	2113314	Yes
1546	2563	1281.5	108.8	54.4	Role of free radicals and catalytic metal ions in human disease: an overview.	B Halliwell, J M Gutteridge	Methods Enzymol	1990	2172697	No
1547	1281	1281.0	0.0	0.0	Paced auditory serial-addition task: a measure of recovery from concussion.	D M Gronwall	Percept Mot Skills	1977	866038	Yes
1548	1281	1281.0	52.43	52.4	The crisis in antibiotic resistance.	H C Neu	Science	1992	1509257	No
1549	2562	1281.0	82.26	41.1	An information-maximization approach to blind separation and blind deconvolution.	A J Bell, T J Sejnowski	Neural Comput	1995	7584893	Yes
1550	2562	1281.0	69.33	34.7	Adipose tissue as an endocrine organ.	Erin E Kershaw, Jeffrey S Flier	J Clin Endocrinol Metab	2004	15181022	No
1551	1281	1281.0	48.29	48.3	Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances.	Joseph J Volpe	Lancet Neurol	2009	19081519	No
1552	1280	1280.0	0.0	0.0	R factor transfer in Rhizobium leguminosarum.	J E Beringer	J Gen Microbiol	1974	4612098	Yes
1553	1279	1279.0	0.0	0.0	Fluorescence energy transfer as a spectroscopic ruler.	L Stryer	Annu Rev Biochem	1978	354506	No
1554	1279	1279.0	0.0	0.0	A simple fluorometric assay for lipoperoxide in blood plasma.	K Yagi	Biochem Med	1976	962904	Yes
1555	1278	1278.0	33.21	33.2	A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin.	D A Gewirtz	Biochem Pharmacol	1999	10075079	No
1556	3833	1277.7	125.24	41.7	Dating of the human-ape splitting by a molecular clock of mitochondrial DNA.	M Hasegawa, H Kishino, T Yano	J Mol Evol	1985	3934395	Yes
1557	1276	1276.0	33.06	33.1	Neurovascular regulation in the normal brain and in Alzheimer's disease.	Costantino Iadecola	Nat Rev Neurosci	2004	15100718	No
1558	1276	1276.0	0.0	0.0	Impulses and Physiological States in Theoretical Models of Nerve Membrane.	R Fitzhugh	Biophys J	1961	19431309	Yes
1559	10203	1275.4	387.36	48.4	Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.	R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A Erlich	Science	1988	2448875	Yes
1560	5101	1275.2	150.87	37.7	p53 mutations in human cancers.	M Hollstein, D Sidransky, B Vogelstein, C C Harris	Science	1991	1905840	No
1561	1275	1275.0	25.13	25.1	Aggresomes, inclusion bodies and protein aggregation.	R R Kopito	Trends Cell Biol	2000	11121744	No
1562	2550	1275.0	66.52	33.3	The human plasma proteome: history, character, and diagnostic prospects.	N Leigh Anderson, Norman G Anderson	Mol Cell Proteomics	2002	12488461	No
1563	1275	1275.0	42.25	42.2	Systemic lupus erythematosus.	George C Tsokos	N Engl J Med	2011	22129255	No
1564	3820	1273.3	160.97	53.7	A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study.	J R Le Gall, S Lemeshow, F Saulnier	JAMA	1993	8254858	Yes
1565	1273	1273.0	35.25	35.2	Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology.	B Winkel-Shirley	Plant Physiol	2001	11402179	No
1566	2544	1272.0	61.56	30.8	Neurotrophins: roles in neuronal development and function.	E J Huang, L F Reichardt	Annu Rev Neurosci	2001	11520916	No
1567	2543	1271.5	89.75	44.9	Oxidative stress, glutamate, and neurodegenerative disorders.	J T Coyle, P Puttfarcken	Science	1993	7901908	No
1568	1271	1271.0	60.11	60.1	Modeling and variable selection in epidemiologic analysis.	S Greenland	Am J Public Health	1989	2916724	Yes
1569	1271	1271.0	50.85	50.9	Cellular defenses against damage from reactive oxygen species.	B P Yu	Physiol Rev	1994	8295932	No
1570	2542	1271.0	73.2	36.6	Quantum dot bioconjugates for ultrasensitive nonisotopic detection.	W C Chan, S Nie	Science	1998	9748158	Yes
1571	1270	1270.0	48.09	48.1	Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders.	Berislav V Zlokovic	Nat Rev Neurosci	2011	22048062	No
1572	2539	1269.5	52.26	26.1	The evolutionary fate and consequences of duplicate genes.	M Lynch, J S Conery	Science	2000	11073452	No
1573	2538	1269.0	82.62	41.3	Rapid and sensitive protein similarity searches.	D J Lipman, W R Pearson	Science	1985	2983426	Yes
1574	1269	1269.0	43.22	43.2	The many roles for fluorine in medicinal chemistry.	William K Hagmann	J Med Chem	2008	18570365	Yes
1575	2535	1267.5	68.66	34.3	Malignant gliomas in adults.	Patrick Y Wen, Santosh Kesari	N Engl J Med	2008	18669428	No
1576	1267	1267.0	0.0	0.0	Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal.	S COHEN	J Biol Chem	1962	13880319	Yes
1577	2532	1266.0	0.0	0.0	Multiple receptors for dopamine.	J W Kebabian, D B Calne	Nature	1979	215920	No
1578	1266	1266.0	39.28	39.3	Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease.	Michael F Holick	Am J Clin Nutr	2004	15585788	No
1579	1266	1266.0	30.19	30.2	The NCI60 human tumour cell line anticancer drug screen.	Robert H Shoemaker	Nat Rev Cancer	2006	16990858	No
1580	1265	1265.0	0.0	0.0	The inverse care law.	J T Hart	Lancet	1971	4100731	Yes
1581	1265	1265.0	27.98	28.0	Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy.	R K Jain	Nat Med	2001	11533692	No
1582	3794	1264.7	0.0	0.0	Impact of Event Scale: a measure of subjective stress.	M Horowitz, N Wilner, W Alvarez	Psychosom Med	1979	472086	Yes
1583	1264	1264.0	59.37	59.4	Probiotics in man and animals.	R Fuller	J Appl Bacteriol	1989	2666378	No
1584	1264	1264.0	64.15	64.2	Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides.	P Holzer	Neuroscience	1988	3288903	No
1585	1264	1264.0	47.04	47.0	Efficient analysis of experimental observations.	W J Dixon	Annu Rev Pharmacol Toxicol	1980	7387124	Yes
1586	1264	1264.0	75.14	75.1	Measurement of health state utilities for economic appraisal.	G W Torrance	J Health Econ	1986	10311607	No
1587	3792	1264.0	99.19	33.1	Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets.	Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck Ørntoft	Cancer Res	2004	15289330	Yes
1588	5052	1263.0	148.47	37.1	Use of T7 RNA polymerase to direct expression of cloned genes.	F W Studier, A H Rosenberg, J J Dunn, J W Dubendorff	Methods Enzymol	1990	2199796	Yes
1589	1263	1263.0	35.35	35.4	HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy.	J M Coffin	Science	1995	7824947	Yes
1590	3785	1261.7	104.18	34.7	Two-photon laser scanning fluorescence microscopy.	W Denk, J H Strickler, W W Webb	Science	1990	2321027	Yes
1591	2523	1261.5	91.87	45.9	Density functionals with broad applicability in chemistry.	Yan Zhao, Donald G Truhlar	Acc Chem Res	2008	18186612	Yes
1592	1261	1261.0	0.0	0.0	Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment.	K O Fagerström	Addict Behav	1978	735910	Yes
1593	1261	1261.0	23.51	23.5	Histone acetylation and transcriptional regulatory mechanisms.	K Struhl	Genes Dev	1998	9499396	No
1594	1261	1261.0	34.82	34.8	Myeloperoxidase: friend and foe.	Seymour J Klebanoff	J Leukoc Biol	2005	15689384	No
1595	1261	1261.0	53.5	53.5	Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement.	Virginia A Moyer	Ann Intern Med	2012	22801674	No
1596	2521	1260.5	63.49	31.7	Lipopolysaccharide endotoxins.	Christian R H Raetz, Chris Whitfield	Annu Rev Biochem	2002	12045108	No
1597	1260	1260.0	30.13	30.1	Tumor metastasis: mechanistic insights and clinical challenges.	Patricia S Steeg	Nat Med	2006	16892035	No
1598	1259	1259.0	0.0	0.0	Which elements are excited in electrical stimulation of mammalian central nervous system: a review.	J B Ranck	Brain Res	1975	1102064	No
1599	1259	1259.0	38.16	38.2	Binary Agrobacterium vectors for plant transformation.	M Bevan	Nucleic Acids Res	1984	6095209	Yes
1600	1258	1258.0	54.6	54.6	The case-crossover design: a method for studying transient effects on the risk of acute events.	M Maclure	Am J Epidemiol	1991	1985444	Yes
1601	1258	1258.0	42.14	42.1	Surface plasmon resonance sensors for detection of chemical and biological species.	Jirí Homola	Chem Rev	2008	18229953	No
1602	1258	1258.0	68.86	68.9	Statistics corner: A guide to appropriate use of correlation coefficient in medical research.	M M Mukaka	Malawi Med J	2012	23638278	Yes
1603	2515	1257.5	83.07	41.5	Mechanisms of salinity tolerance.	Rana Munns, Mark Tester	Annu Rev Plant Biol	2008	18444910	No
1604	2514	1257.0	0.0	0.0	A "DIRECT-COLORING" THIOCHOLINE METHOD FOR CHOLINESTERASES.	M J KARNOVSKY, L ROOTS	J Histochem Cytochem	1964	14187330	Yes
1605	16341	1257.0	483.31	37.2	Clustal W and Clustal X version 2.0.	M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G Higgins	Bioinformatics	2007	17846036	Yes
1606	7537	1256.2	267.0	44.5	New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0.	Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier Gascuel	Syst Biol	2010	20525638	Yes
1607	1256	1256.0	0.0	0.0	Amino acid difference formula to help explain protein evolution.	R Grantham	Science	1974	4843792	Yes
1608	1256	1256.0	0.0	0.0	The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations.	W W CLELAND	Biochim Biophys Acta	1963	14021667	Yes
1609	1255	1255.0	39.47	39.5	Alpha-crystallin can function as a molecular chaperone.	J Horwitz	Proc Natl Acad Sci U S A	1992	1438232	Yes
1610	1255	1255.0	57.4	57.4	Simple proton spectroscopic imaging.	W T Dixon	Radiology	1984	6089263	Yes
1611	2508	1254.0	0.0	0.0	Prediction of the secondary structure of proteins from their amino acid sequence.	P Y Chou, G D Fasman	Adv Enzymol Relat Areas Mol Biol	1978	364941	No
1612	2508	1254.0	67.51	33.8	Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.	F Q Schafer, G R Buettner	Free Radic Biol Med	2001	11368918	No
1613	2508	1254.0	56.43	28.2	The Bcl2 family: regulators of the cellular life-or-death switch.	Suzanne Cory, Jerry M Adams	Nat Rev Cancer	2002	12209154	No
1614	1253	1253.0	43.47	43.5	The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function.	R R Llinás	Science	1988	3059497	No
1615	1253	1253.0	32.93	32.9	Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis.	S C Manolagas	Endocr Rev	2000	10782361	No
1616	1253	1253.0	35.22	35.2	Use and misuse of the receiver operating characteristic curve in risk prediction.	Nancy R Cook	Circulation	2007	17309939	Yes
1617	1253	1253.0	61.7	61.7	The emerging role of lncRNAs in cancer.	Maite Huarte	Nat Med	2015	26540387	No
1618	3758	1252.7	90.33	30.1	NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.	S Ghosh, M J May, E B Kopp	Annu Rev Immunol	1998	9597130	No
1619	3757	1252.3	116.25	38.8	The fusiform face area: a module in human extrastriate cortex specialized for face perception.	N Kanwisher, J McDermott, M M Chun	J Neurosci	1997	9151747	Yes
1620	5009	1252.2	294.03	73.5	The Satisfaction With Life Scale.	E Diener, R A Emmons, R J Larsen, S Griffin	J Pers Assess	1985	16367493	Yes
1621	1252	1252.0	31.57	31.6	The molecular logic of endocannabinoid signalling.	Daniele Piomelli	Nat Rev Neurosci	2003	14595399	No
1622	1251	1251.0	36.11	36.1	Stress and hippocampal plasticity.	B S McEwen	Annu Rev Neurosci	1999	10202533	No
1623	1251	1251.0	29.96	30.0	Hematopoietic stem-cell transplantation.	Edward A Copelan	N Engl J Med	2006	16641398	No
1624	2502	1251.0	59.09	29.5	Cancer metastasis: building a framework.	Gaorav P Gupta, Joan Massagué	Cell	2006	17110329	No
1625	1250	1250.0	33.37	33.4	On finding all suboptimal foldings of an RNA molecule.	M Zuker	Science	1989	2468181	No
1626	1250	1250.0	32.81	32.8	Neuronal synchrony: a versatile code for the definition of relations?	W Singer	Neuron	1999	10677026	No
1627	1250	1250.0	28.52	28.5	DNA in a material world.	Nadrian C Seeman	Nature	2003	12540916	No
1628	1250	1250.0	41.07	41.1	Leishmaniasis: current situation and new perspectives.	P Desjeux	Comp Immunol Microbiol Infect Dis	2004	15225981	No
1629	1250	1250.0	29.01	29.0	Cancer epigenomics: DNA methylomes and histone-modification maps.	Manel Esteller	Nat Rev Genet	2007	17339880	No
1630	1247	1247.0	51.21	51.2	Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue').	M N Marsh	Gastroenterology	1992	1727768	No
1631	1247	1247.0	29.73	29.7	How eukaryotic transcriptional activators work.	M Ptashne	Nature	1988	3050531	No
1632	1247	1247.0	45.64	45.6	El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. Subcommittee on Motor Neuron Diseases/Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial "Clinical limits of amyotrophic lateral sclerosis" workshop contributors.	B R Brooks	J Neurol Sci	1994	7807156	Yes
1633	1247	1247.0	41.64	41.6	Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat.	P A Bradford	Clin Microbiol Rev	2001	11585791	No
1634	3740	1246.7	86.65	28.9	TOR signaling in growth and metabolism.	Stephan Wullschleger, Robbie Loewith, Michael N Hall	Cell	2006	16469695	No
1635	2493	1246.5	0.0	0.0	The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites.	J Shine, L Dalgarno	Proc Natl Acad Sci U S A	1974	4598299	Yes
1636	2493	1246.5	79.07	39.5	Diarrheagenic Escherichia coli.	J P Nataro, J B Kaper	Clin Microbiol Rev	1998	9457432	No
1637	1246	1246.0	33.39	33.4	NADPH oxidase: an update.	B M Babior	Blood	1999	10029572	No
1638	2492	1246.0	84.46	42.2	EQ-5D: a measure of health status from the EuroQol Group.	R Rabin, F de Charro	Ann Med	2001	11491192	No
1639	3736	1245.3	147.71	49.2	Phylogenetic identification and in situ detection of individual microbial cells without cultivation.	R I Amann, W Ludwig, K H Schleifer	Microbiol Rev	1995	7535888	No
1640	1245	1245.0	0.0	0.0	Synaptic density in human frontal cortex - developmental changes and effects of aging.	P R Huttenlocher	Brain Res	1979	427544	Yes
1641	1244	1244.0	0.0	0.0	The influence of some cations on an adenosine triphosphatase from peripheral nerves.	J C SKOU	Biochim Biophys Acta	1957	13412736	Yes
1642	1244	1244.0	29.32	29.3	A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other.	Dale R Nyholt	Am J Hum Genet	2004	14997420	Yes
1643	2488	1244.0	103.82	51.9	Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants.	Sarvajeet Singh Gill, Narendra Tuteja	Plant Physiol Biochem	2010	20870416	No
1644	2486	1243.0	56.42	28.2	Chemokines: a new classification system and their role in immunity.	A Zlotnik, O Yoshie	Immunity	2000	10714678	No
1645	4970	1242.5	176.54	44.1	The validity of the Hospital Anxiety and Depression Scale. An updated literature review.	Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag Neckelmann	J Psychosom Res	2002	11832252	No
1646	8695	1242.1	196.17	28.0	Embryonic stem cell lines derived from human blastocysts.	J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M Jones	Science	1998	9804556	Yes
1647	2484	1242.0	63.39	31.7	How matrix metalloproteinases regulate cell behavior.	M D Sternlicht, Z Werb	Annu Rev Cell Dev Biol	2001	11687497	No
1648	4965	1241.2	310.54	77.6	Prevalence of childhood and adult obesity in the United States, 2011-2012.	Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M Flegal	JAMA	2014	24570244	Yes
1649	2482	1241.0	54.84	27.4	Development by self-digestion: molecular mechanisms and biological functions of autophagy.	Beth Levine, Daniel J Klionsky	Dev Cell	2004	15068787	No
1650	1240	1240.0	40.31	40.3	The pathophysiology of tumor necrosis factors.	P Vassalli	Annu Rev Immunol	1992	1590993	No
1651	1240	1240.0	0.0	0.0	The recurrence of intracranial meningiomas after surgical treatment.	D SIMPSON	J Neurol Neurosurg Psychiatry	1957	13406590	Yes
1652	2480	1240.0	82.03	41.0	Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research.	Sally S Dickerson, Margaret E Kemeny	Psychol Bull	2004	15122924	Yes
1653	3718	1239.3	137.13	45.7	Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration.	Helga Thorvaldsdóttir, James T Robinson, Jill P Mesirov	Brief Bioinform	2013	22517427	Yes
1654	1239	1239.0	0.0	0.0	Stability of proteins: small globular proteins.	P L Privalov	Adv Protein Chem	1979	44431	No
1655	2478	1239.0	117.88	58.9	The mini-mental state examination: a comprehensive review.	T N Tombaugh, N J McIntyre	J Am Geriatr Soc	1992	1512391	No
1656	1239	1239.0	50.97	51.0	Number of people with glaucoma worldwide.	H A Quigley	Br J Ophthalmol	1996	8695555	No
1657	7430	1238.3	335.57	55.9	Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.	L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R Tannenbaum	Anal Biochem	1982	7181105	Yes
1658	3712	1237.3	85.92	28.6	Toll-like receptors.	Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira	Annu Rev Immunol	2003	12524386	No
1659	1237	1237.0	34.85	34.9	The amygdala modulates the consolidation of memories of emotionally arousing experiences.	James L McGaugh	Annu Rev Neurosci	2004	15217324	No
1660	1237	1237.0	33.61	33.6	The failing heart--an engine out of fuel.	Stefan Neubauer	N Engl J Med	2007	17360992	No
1661	2471	1235.5	66.09	33.0	Unravelling the pathogenesis of inflammatory bowel disease.	R J Xavier, D K Podolsky	Nature	2007	17653185	No
1662	1235	1235.0	32.72	32.7	Origin, biogenesis, and activity of plant microRNAs.	Olivier Voinnet	Cell	2009	19239888	No
1663	1234	1234.0	0.0	0.0	Influences of glucose loading and of injected insulin on hepatic glucose output.	R STEELE	Ann N Y Acad Sci	1959	13833973	Yes
1664	3702	1234.0	116.83	38.9	Optimization by simulated annealing.	S Kirkpatrick, C D Gelatt, M P Vecchi	Science	1983	17813860	Yes
1665	3701	1233.7	139.49	46.5	Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions.	Aleksandr V Marenich, Christopher J Cramer, Donald G Truhlar	J Phys Chem B	2009	19366259	Yes
1666	2466	1233.0	66.3	33.1	Steatohepatitis: a tale of two "hits"?	C P Day, O F James	Gastroenterology	1998	9547102	No
1667	1233	1233.0	0.0	0.0	Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.	J M VAN ROSSUM	Arch Int Pharmacodyn Ther	1963	13996119	Yes
1668	1233	1233.0	0.0	0.0	TRANSFORMATION OF BIOCHEMICALLY DEFICIENT STRAINS OF BACILLUS SUBTILIS BY DEOXYRIBONUCLEATE.	J Spizizen	Proc Natl Acad Sci U S A	1958	16590310	Yes
1669	4931	1232.8	0.0	0.0	Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.	E A Jaffe, R L Nachman, C G Becker, C R Minick	J Clin Invest	1973	4355998	Yes
1670	1231	1231.0	0.0	0.0	Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat.	C A Barnes	J Comp Physiol Psychol	1979	221551	Yes
1671	2461	1230.5	74.04	37.0	Materials for electrochemical capacitors.	Patrice Simon, Yury Gogotsi	Nat Mater	2008	18956000	Yes
1672	1230	1230.0	64.52	64.5	Cell damage in the brain: a speculative synthesis.	B K Siesjö	J Cereb Blood Flow Metab	1981	6276420	No
1673	1230	1230.0	28.54	28.5	Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.	S S Ferguson	Pharmacol Rev	2001	11171937	No
1674	1229	1229.0	23.41	23.4	Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy.	M G Gustafsson	J Microsc	2000	10810003	Yes
1675	1229	1229.0	36.0	36.0	External validity of randomised controlled trials: "to whom do the results of this trial apply?".	Peter M Rothwell	Lancet	2005	15639683	Yes
1676	2455	1227.5	94.24	47.1	Saliency, switching, attention and control: a network model of insula function.	Vinod Menon, Lucina Q Uddin	Brain Struct Funct	2010	20512370	No
1677	6137	1227.4	284.24	56.8	UCHIME improves sensitivity and speed of chimera detection.	Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob Knight	Bioinformatics	2011	21700674	Yes
1678	1227	1227.0	42.41	42.4	Interleukin-6: an overview.	J Van Snick	Annu Rev Immunol	1990	2188664	No
1679	1227	1227.0	79.02	79.0	Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control.	F E Zajac	Crit Rev Biomed Eng	1989	2676342	No
1680	2454	1227.0	0.0	0.0	Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation.	R L Heath, L Packer	Arch Biochem Biophys	1968	5655425	Yes
1681	1227	1227.0	30.92	30.9	Neurotrophin-regulated signalling pathways.	Louis F Reichardt	Philos Trans R Soc Lond B Biol Sci	2006	16939974	No
1682	1227	1227.0	60.66	60.7	Pro-resolving lipid mediators are leads for resolution physiology.	Charles N Serhan	Nature	2014	24899309	No
1683	1226	1226.0	75.94	75.9	The structure and properties of the sense of coherence scale.	A Antonovsky	Soc Sci Med	1993	8480217	Yes
1684	2451	1225.5	52.92	26.5	Mutations affecting segment number and polarity in Drosophila.	C Nüsslein-Volhard, E Wieschaus	Nature	1980	6776413	Yes
1685	2449	1224.5	76.31	38.2	Lipid rafts as a membrane-organizing principle.	Daniel Lingwood, Kai Simons	Science	2010	20044567	No
1686	1224	1224.0	0.0	0.0	METHOD FOR ASSAY OF INTESTINAL DISACCHARIDASES.	A DAHLQVIST	Anal Biochem	1964	14106916	Yes
1687	4896	1224.0	131.15	32.8	The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling.	Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten Schwede	Bioinformatics	2006	16301204	Yes
1688	4895	1223.8	134.4	33.6	Most mammalian mRNAs are conserved targets of microRNAs.	Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel	Genome Res	2009	18955434	Yes
1689	3671	1223.7	132.82	44.3	Estimating the mean and variance from the median, range, and the size of a sample.	Stela Pudar Hozo, Benjamin Djulbegovic, Iztok Hozo	BMC Med Res Methodol	2005	15840177	Yes
1690	2447	1223.5	88.76	44.4	Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons.	M Karas, F Hillenkamp	Anal Chem	1988	3239801	Yes
1691	1223	1223.0	33.34	33.3	The proto-oncogene Bcl-2 and its role in regulating apoptosis.	G Kroemer	Nat Med	1997	9176486	No
1692	2445	1222.5	53.82	26.9	Intrinsically unstructured proteins and their functions.	H Jane Dyson, Peter E Wright	Nat Rev Mol Cell Biol	2005	15738986	No
1693	1222	1222.0	37.12	37.1	Molecular biology of prion diseases.	S B Prusiner	Science	1991	1675487	No
1694	2444	1222.0	87.51	43.8	From best evidence to best practice: effective implementation of change in patients' care.	Richard Grol, Jeremy Grimshaw	Lancet	2003	14568747	No
1695	2443	1221.5	0.0	0.0	A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms.	J A Horne, O Ostberg	Int J Chronobiol	1976	1027738	Yes
1696	4884	1221.0	249.89	62.5	An inventory for measuring clinical anxiety: psychometric properties.	A T Beck, N Epstein, G Brown, R A Steer	J Consult Clin Psychol	1988	3204199	Yes
1697	1221	1221.0	41.4	41.4	Semiempirical hybrid density functional with perturbative second-order correlation.	Stefan Grimme	J Chem Phys	2006	16438568	Yes
1698	2441	1220.5	109.63	54.8	Regulation of microRNA biogenesis.	Minju Ha, V Narry Kim	Nat Rev Mol Cell Biol	2014	25027649	No
1699	1219	1219.0	0.0	0.0	Determination of free amino groups in proteins by trinitrobenzenesulfonic acid.	A F Habeeb	Anal Biochem	1966	4161471	Yes
1700	1219	1219.0	0.0	0.0	The genetical evolution of social behaviour. II.	W D Hamilton	J Theor Biol	1964	5875340	Yes
1701	2437	1218.5	58.16	29.1	Microtubules as a target for anticancer drugs.	Mary Ann Jordan, Leslie Wilson	Nat Rev Cancer	2004	15057285	No
1702	1218	1218.0	61.93	61.9	Responses to depression and their effects on the duration of depressive episodes.	S Nolen-Hoeksema	J Abnorm Psychol	1991	1757671	No
1703	2436	1218.0	0.0	0.0	The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat.	J O'Keefe, J Dostrovsky	Brain Res	1971	5124915	Yes
1704	3654	1218.0	102.85	34.3	Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system.	B Fischl, M I Sereno, A M Dale	Neuroimage	1999	9931269	Yes
1705	1218	1218.0	25.92	25.9	Macromolecular crowding: obvious but underappreciated.	R J Ellis	Trends Biochem Sci	2001	11590012	No
1706	1216	1216.0	42.78	42.8	Stress signalling pathways that impair prefrontal cortex structure and function.	Amy F T Arnsten	Nat Rev Neurosci	2009	19455173	No
1707	1215	1215.0	47.09	47.1	Extracellular ATP: effects, sources and fate.	J L Gordon	Biochem J	1986	3006665	No
1708	1215	1215.0	27.83	27.8	The ubiquitin-proteasome proteolytic pathway.	A Ciechanover	Cell	1994	7923371	No
1709	3644	1214.7	95.95	32.0	Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies.	Daniel Falush, Matthew Stephens, Jonathan K Pritchard	Genetics	2003	12930761	Yes
1710	1214	1214.0	32.65	32.6	The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting.	H Maeda	Adv Enzyme Regul	2001	11384745	No
1711	2428	1214.0	78.09	39.0	Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper.	B R Celli, W MacNee	Eur Respir J	2004	15219010	No
1712	1213	1213.0	0.0	0.0	Disconnexion syndromes in animals and man. I.	N Geschwind	Brain	1965	5318481	No
1713	1213	1213.0	46.32	46.3	Evidence for a central component of post-injury pain hypersensitivity.	C J Woolf	Nature	1983	6656869	Yes
1714	1213	1213.0	50.82	50.8	Dual-task interference in simple tasks: data and theory.	H Pashler	Psychol Bull	1994	7972591	No
1715	1213	1213.0	33.01	33.0	Oxidative stress in Parkinson's disease.	Peter Jenner	Ann Neurol	2003	12666096	No
1716	2426	1213.0	61.54	30.8	A comparison of bayesian methods for haplotype reconstruction from population genotype data.	Matthew Stephens, Peter Donnelly	Am J Hum Genet	2003	14574645	Yes
1717	4851	1212.8	0.0	0.0	A rating scale for mania: reliability, validity and sensitivity.	R C Young, J T Biggs, V E Ziegler, D A Meyer	Br J Psychiatry	1978	728692	Yes
1718	2424	1212.0	64.03	32.0	A novel multigene family may encode odorant receptors: a molecular basis for odor recognition.	L Buck, R Axel	Cell	1991	1840504	Yes
1719	2423	1211.5	69.24	34.6	Obesity.	David W Haslam, W Philip T James	Lancet	2005	16198769	No
1720	2422	1211.0	117.83	58.9	Assessment of eating disorders: interview or self-report questionnaire?	C G Fairburn, S J Beglin	Int J Eat Disord	1994	7866415	Yes
1721	1211	1211.0	47.3	47.3	The polyvagal perspective.	Stephen W Porges	Biol Psychol	2007	17049418	No
1722	6054	1210.8	0.0	0.0	STUDIES OF ILLNESS IN THE AGED. THE INDEX OF ADL: A STANDARDIZED MEASURE OF BIOLOGICAL AND PSYCHOSOCIAL FUNCTION.	S KATZ, A B FORD, R W MOSKOWITZ, B A JACKSON, M W JAFFE	JAMA	1963	14044222	Yes
1723	2420	1210.0	60.09	30.0	NF-kappaB: a key role in inflammatory diseases.	P P Tak, G S Firestein	J Clin Invest	2001	11134171	No
1724	1210	1210.0	45.35	45.4	Social relationships and health.	Sheldon Cohen	Am Psychol	2004	15554821	No
1725	1209	1209.0	75.18	75.2	Chronic illness as biographical disruption.	M Bury	Sociol Health Illn	1982	10260456	Yes
1726	1209	1209.0	23.06	23.1	The DNA methyltransferases of mammals.	T H Bestor	Hum Mol Genet	2000	11005794	No
1727	2414	1207.0	60.57	30.3	Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.	T Miyashita, J C Reed	Cell	1995	7834749	Yes
1728	2413	1206.5	80.57	40.3	A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes.	S Tabor, C C Richardson	Proc Natl Acad Sci U S A	1985	3156376	Yes
1729	1206	1206.0	0.0	0.0	The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers.	R Ross	J Cell Biol	1971	4327464	Yes
1730	2412	1206.0	91.02	45.5	Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics.	G R Gibson, M B Roberfroid	J Nutr	1995	7782892	No
1731	1206	1206.0	24.65	24.6	Epithelial-mesenchymal transitions in development and pathologies.	Jean Paul Thiery	Curr Opin Cell Biol	2003	14644200	No
1732	1206	1206.0	64.39	64.4	Gctf: Real-time CTF determination and correction.	Kai Zhang	J Struct Biol	2016	26592709	Yes
1733	1205	1205.0	40.85	40.9	DNA topoisomerases.	J C Wang	Annu Rev Biochem	1985	2992360	No
1734	1205	1205.0	49.78	49.8	Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson.	H J Gundersen	J Microsc	1986	3761363	Yes
1735	1205	1205.0	23.98	24.0	Ubiquitin-dependent protein degradation.	M Hochstrasser	Annu Rev Genet	1996	8982460	No
1736	1205	1205.0	28.27	28.3	Critical period plasticity in local cortical circuits.	Takao K Hensch	Nat Rev Neurosci	2005	16261181	No
1737	2410	1205.0	76.91	38.5	miRBase: integrating microRNA annotation and deep-sequencing data.	Ana Kozomara, Sam Griffiths-Jones	Nucleic Acids Res	2011	21037258	Yes
1738	1204	1204.0	31.34	31.3	Molecular basis of long-term plasticity underlying addiction.	E J Nestler	Nat Rev Neurosci	2001	11252991	No
1739	1204	1204.0	26.82	26.8	Stability and flexibility of epigenetic gene regulation in mammalian development.	Wolf Reik	Nature	2007	17522676	No
1740	4813	1203.2	130.91	32.7	Improved prediction of signal peptides: SignalP 3.0.	Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren Brunak	J Mol Biol	2004	15223320	Yes
1741	2406	1203.0	52.38	26.2	A guided tour into subcellular colocalization analysis in light microscopy.	S Bolte, F P Cordelières	J Microsc	2006	17210054	Yes
1742	1203	1203.0	0.0	0.0	Cognitive maps in rats and men.	E C TOLMAN	Psychol Rev	1948	18870876	Yes
1743	2405	1202.5	67.57	33.8	Macrophage diversity enhances tumor progression and metastasis.	Bin-Zhi Qian, Jeffrey W Pollard	Cell	2010	20371344	No
1744	1201	1201.0	0.0	0.0	Ionic blockage of sodium channels in nerve.	A M Woodhull	J Gen Physiol	1973	4541078	Yes
1745	2401	1200.5	74.54	37.3	Early identification of refractory epilepsy.	P Kwan, M J Brodie	N Engl J Med	2000	10660394	Yes
1746	2401	1200.5	78.59	39.3	Protective and pathogenic functions of macrophage subsets.	Peter J Murray, Thomas A Wynn	Nat Rev Immunol	2011	21997792	No
1747	1200	1200.0	25.97	26.0	Altering the genome by homologous recombination.	M R Capecchi	Science	1989	2660260	No
1748	1199	1199.0	44.56	44.6	The biology of interleukin-6.	T Kishimoto	Blood	1989	2473791	No
1749	2398	1199.0	117.15	58.6	Deciphering key features in protein structures with the new ENDscript server.	Xavier Robert, Patrice Gouet	Nucleic Acids Res	2014	24753421	Yes
1750	7190	1198.3	204.77	34.1	Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.	D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuire	Science	1987	3798106	Yes
1751	2396	1198.0	118.97	59.5	Avoiding false positives with PCR.	S Kwok, R Higuchi	Nature	1989	2716852	Yes
1752	2396	1198.0	87.37	43.7	Prediction of protein antigenic determinants from amino acid sequences.	T P Hopp, K R Woods	Proc Natl Acad Sci U S A	1981	6167991	Yes
1753	10778	1197.6	389.98	43.3	The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10.	D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C Dunbar	J Clin Psychiatry	1998	9881538	No
1754	2392	1196.0	68.69	34.3	The biology of vascular endothelial growth factor.	N Ferrara, T Davis-Smyth	Endocr Rev	1997	9034784	No
1755	3588	1196.0	167.31	55.8	Molecular mechanisms of epithelial-mesenchymal transition.	Samy Lamouille, Jian Xu, Rik Derynck	Nat Rev Mol Cell Biol	2014	24556840	No
1756	2390	1195.0	95.58	47.8	The efficiency of systematic sampling in stereology and its prediction.	H J Gundersen, E B Jensen	J Microsc	1987	3430576	Yes
1757	3584	1194.7	87.2	29.1	Osteoclast differentiation and activation.	William J Boyle, W Scott Simonet, David L Lacey	Nature	2003	12748652	No
1758	3582	1194.0	109.61	36.5	TCS: a computer program to estimate gene genealogies.	M Clement, D Posada, K A Crandall	Mol Ecol	2000	11050560	Yes
1759	1193	1193.0	47.0	47.0	Polycystic ovary syndrome.	S Franks	N Engl J Med	1995	7651477	No
1760	2386	1193.0	49.92	25.0	Cancer genes and the pathways they control.	Bert Vogelstein, Kenneth W Kinzler	Nat Med	2004	15286780	No
1761	1193	1193.0	48.33	48.3	Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies.	Peter C Austin	Pharm Stat	2011	20925139	Yes
1762	3578	1192.7	108.06	36.0	Regularization Paths for Generalized Linear Models via Coordinate Descent.	Jerome Friedman, Trevor Hastie, Rob Tibshirani	J Stat Softw	2010	20808728	Yes
1763	1192	1192.0	40.0	40.0	Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms.	J A Beavo	Physiol Rev	1995	7480160	No
1764	1192	1192.0	31.79	31.8	The mitochondrial permeability transition pore and its role in cell death.	M Crompton	Biochem J	1999	10393078	No
1765	2383	1191.5	52.53	26.3	Short-term synaptic plasticity.	Robert S Zucker, Wade G Regehr	Annu Rev Physiol	2002	11826273	No
1766	10722	1191.3	407.24	45.2	STAR: ultrafast universal RNA-seq aligner.	Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R Gingeras	Bioinformatics	2013	23104886	Yes
1767	2382	1191.0	172.63	86.3	Rating systems in the evaluation of knee ligament injuries.	Y Tegner, J Lysholm	Clin Orthop Relat Res	1985	4028566	Yes
1768	1191	1191.0	0.0	0.0	Structural considerations in the interaction of DNA and acridines.	L S LERMAN	J Mol Biol	1961	13761054	Yes
1769	2382	1191.0	50.14	25.1	Wnt signalling in stem cells and cancer.	Tannishtha Reya, Hans Clevers	Nature	2005	15829953	No
1770	1190	1190.0	0.0	0.0	Dynamic properties of mammalian skeletal muscles.	R I Close	Physiol Rev	1972	4256989	No
1771	1190	1190.0	31.67	31.7	PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.	B M Spiegelman	Diabetes	1998	9568680	No
1772	2380	1190.0	60.44	30.2	The pathophysiology and treatment of sepsis.	Richard S Hotchkiss, Irene E Karl	N Engl J Med	2003	12519925	No
1773	1190	1190.0	0.0	0.0	The etiology of chondromalacia patellae.	R E OUTERBRIDGE	J Bone Joint Surg Br	1961	14038135	Yes
1774	1190	1190.0	42.63	42.6	Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research.	M Robin DiMatteo	Med Care	2004	15076819	Yes
1775	1189	1189.0	38.24	38.2	Trophic factors and neuronal survival.	Y A Barde	Neuron	1989	2697237	No
1776	1189	1189.0	96.49	96.5	The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system.	F C Ewald	Clin Orthop Relat Res	1989	2805502	Yes
1777	1189	1189.0	66.91	66.9	The contribution of low birth weight to infant mortality and childhood morbidity.	M C McCormick	N Engl J Med	1985	3880598	No
1778	1189	1189.0	0.0	0.0	Interhemispheric differences in the localization of psychological processes in man.	B Milner	Br Med Bull	1971	4937273	No
1779	1189	1189.0	22.75	22.8	Chromatin modification and epigenetic reprogramming in mammalian development.	En Li	Nat Rev Genet	2002	12209141	No
1780	1188	1188.0	38.98	39.0	A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology.	J Engel	Epilepsia	2001	11422340	Yes
1781	1188	1188.0	21.77	21.8	Protein modification by SUMO.	Erica S Johnson	Annu Rev Biochem	2004	15189146	No
1782	1188	1188.0	29.07	29.1	Hyaluronan: from extracellular glue to pericellular cue.	Bryan P Toole	Nat Rev Cancer	2004	15229478	No
1783	4751	1187.8	0.0	0.0	The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care.	S P Baker, B O'Neill, W Haddon, W B Long	J Trauma	1974	4814394	Yes
1784	3563	1187.7	106.42	35.5	Cognitive and emotional influences in anterior cingulate cortex.	Bush, Luu, Posner	Trends Cogn Sci	2000	10827444	Yes
1785	5938	1187.6	157.69	31.5	Site-directed mutagenesis by overlap extension using the polymerase chain reaction.	S N Ho, H D Hunt, R M Horton, J K Pullen, L R Pease	Gene	1989	2744487	Yes
1786	1187	1187.0	61.58	61.6	Sample size in qualitative research.	M Sandelowski	Res Nurs Health	1995	7899572	Yes
1787	1187	1187.0	28.64	28.6	Mitochondria: dynamic organelles in disease, aging, and development.	David C Chan	Cell	2006	16814712	No
1788	1186	1186.0	0.0	0.0	Discharge patterns and functional organization of mammalian retina.	S W KUFFLER	J Neurophysiol	1953	13035466	Yes
1789	2371	1185.5	0.0	0.0	Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans.	D H Figurski, D R Helinski	Proc Natl Acad Sci U S A	1979	377280	Yes
1790	3556	1185.3	1513.13	504.4	Cancer statistics, 2020.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2020	31912902	Yes
1791	1185	1185.0	30.31	30.3	Cell signaling. H2O2, a necessary evil for cell signaling.	Sue Goo Rhee	Science	2006	16809515	Yes
1792	1185	1185.0	46.68	46.7	A Social Neuroscience Perspective on Adolescent Risk-Taking.	Laurence Steinberg	Dev Rev	2008	18509515	Yes
1793	1185	1185.0	32.14	32.1	Lead- and drug-like compounds: the rule-of-five revolution.	Christopher A Lipinski	Drug Discov Today Technol	2004	24981612	Yes
1794	2369	1184.5	77.8	38.9	A perspective on cancer cell metastasis.	Christine L Chaffer, Robert A Weinberg	Science	2011	21436443	No
1795	2368	1184.0	65.71	32.9	Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress.	H Cai, D G Harrison	Circ Res	2000	11073878	No
1796	1183	1183.0	38.1	38.1	Graphene transistors.	Frank Schwierz	Nat Nanotechnol	2010	20512128	Yes
1797	1183	1183.0	46.85	46.9	Functional and effective connectivity: a review.	Karl J Friston	Brain Connect	2011	22432952	No
1798	2365	1182.5	57.27	28.6	Inhibitors of mammalian G1 cyclin-dependent kinases.	C J Sherr, J M Roberts	Genes Dev	1995	7758941	No
1799	1182	1182.0	53.03	53.0	Serum albumin.	T Peters	Adv Protein Chem	1985	3904348	No
1800	3543	1181.0	0.0	0.0	Research diagnostic criteria: rationale and reliability.	R L Spitzer, J Endicott, E Robins	Arch Gen Psychiatry	1978	655775	Yes
1801	1181	1181.0	38.23	38.2	The debate over dopamine's role in reward: the case for incentive salience.	Kent C Berridge	Psychopharmacology (Berl)	2007	17072591	No
1802	1180	1180.0	63.75	63.8	What's in a name? Qualitative description revisited.	Margarete Sandelowski	Res Nurs Health	2010	20014004	Yes
1803	2359	1179.5	82.16	41.1	Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being.	James J Gross, Oliver P John	J Pers Soc Psychol	2003	12916575	Yes
1804	1179	1179.0	40.76	40.8	DNA topoisomerase poisons as antitumor drugs.	L F Liu	Annu Rev Biochem	1989	2549853	No
1805	1179	1179.0	42.28	42.3	Ionic dependence of glutamate neurotoxicity.	D W Choi	J Neurosci	1987	2880938	Yes
1806	1179	1179.0	42.1	42.1	Strong localization of photons in certain disordered dielectric superlattices.	John	Phys Rev Lett	1987	10034761	Yes
1807	1179	1179.0	28.44	28.4	Protein misfolding, evolution and disease.	C M Dobson	Trends Biochem Sci	1999	10470028	No
1808	1179	1179.0	43.19	43.2	Domino Reactions in Organic Synthesis.	Lutz F. Tietze	Chem Rev	1996	11848746	Yes
1809	1178	1178.0	45.25	45.2	Gene flow and the geographic structure of natural populations.	M Slatkin	Science	1987	3576198	Yes
1810	1178	1178.0	36.97	37.0	A note on robust variance estimation for cluster-correlated data.	R L Williams	Biometrics	2000	10877330	Yes
1811	2354	1177.0	86.31	43.2	Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction.	K B Mullis, F A Faloona	Methods Enzymol	1987	3431465	Yes
1812	1177	1177.0	0.0	0.0	ATPase activity of myosin correlated with speed of muscle shortening.	M Bárány	J Gen Physiol	1967	4227924	Yes
1813	2354	1177.0	85.95	43.0	A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.	J Messing, J Vieira	Gene	1982	6295880	Yes
1814	1177	1177.0	46.93	46.9	History of the Rochester Epidemiology Project.	L J Melton	Mayo Clin Proc	1996	8594285	No
1815	1177	1177.0	22.3	22.3	The snail superfamily of zinc-finger transcription factors.	M Angela Nieto	Nat Rev Mol Cell Biol	2002	11994736	No
1816	1177	1177.0	27.68	27.7	Autophagy: from phenomenology to molecular understanding in less than a decade.	Daniel J Klionsky	Nat Rev Mol Cell Biol	2007	17712358	No
1817	4704	1176.0	113.47	28.4	Probability-based protein identification by searching sequence databases using mass spectrometry data.	D N Perkins, D J Pappin, D M Creasy, J S Cottrell	Electrophoresis	1999	10612281	Yes
1818	1176	1176.0	33.56	33.6	Interoception: the sense of the physiological condition of the body.	A D Craig	Curr Opin Neurobiol	2003	12965300	No
1819	1176	1176.0	46.04	46.0	The global impact of pre-eclampsia and eclampsia.	Lelia Duley	Semin Perinatol	2009	19464502	No
1820	2351	1175.5	90.8	45.4	A rapid boiling method for the preparation of bacterial plasmids.	D S Holmes, M Quigley	Anal Biochem	1981	6269464	Yes
1821	1175	1175.0	35.58	35.6	Hydrogels for biomedical applications.	Allan S Hoffman	Adv Drug Deliv Rev	2002	11755703	No
1822	1175	1175.0	43.26	43.3	The functional gastrointestinal disorders and the Rome III process.	Douglas A Drossman	Gastroenterology	2006	16678553	No
1823	2349	1174.5	53.89	26.9	The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.	M S Brown, J L Goldstein	Cell	1997	9150132	No
1824	1174	1174.0	45.81	45.8	The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat.	L W Swanson	Brain Res Bull	1982	6816390	Yes
1825	1174	1174.0	32.46	32.5	A molecular view of microbial diversity and the biosphere.	N R Pace	Science	1997	9115194	No
1826	1174	1174.0	36.48	36.5	The epidemiology of venous thromboembolism.	Richard H White	Circulation	2003	12814979	No
1827	1174	1174.0	31.42	31.4	Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study).	K M Fox	Lancet	2003	13678872	Yes
1828	4693	1173.2	220.96	55.2	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	Int J Surg	2010	20171303	No
1829	4687	1171.8	0.0	0.0	Antibiotic susceptibility testing by a standardized single disk method.	A W Bauer, W M Kirby, J C Sherris, M Turck	Am J Clin Pathol	1966	5325707	Yes
1830	1171	1171.0	50.41	50.4	Aging, natural death, and the compression of morbidity.	J F Fries	N Engl J Med	1980	7383070	Yes
1831	1170	1170.0	36.02	36.0	Steroid receptor regulated transcription of specific genes and gene networks.	K R Yamamoto	Annu Rev Genet	1985	3909942	No
1832	1169	1169.0	0.0	0.0	Mate selection-a selection for a handicap.	A Zahavi	J Theor Biol	1975	1195756	Yes
1833	2338	1169.0	121.56	60.8	Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use.	A Y Finlay, G K Khan	Clin Exp Dermatol	1994	8033378	Yes
1834	1169	1169.0	36.7	36.7	Bioactive microbial metabolites.	János Bérdy	J Antibiot (Tokyo)	2005	15813176	No
1835	2337	1168.5	52.93	26.5	New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites.	R D Gietz, A Sugino	Gene	1988	3073106	Yes
1836	1168	1168.0	42.37	42.4	Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance.	L Bravo	Nutr Rev	1998	9838798	No
1837	1168	1168.0	25.86	25.9	Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators.	R I Morimoto	Genes Dev	1998	9869631	No
1838	1167	1167.0	85.05	85.0	The antibiotic resistance crisis: part 1: causes and threats.	C Lee Ventola	P T	2015	25859123	Yes
1839	1166	1166.0	0.0	0.0	Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.	B Hille	J Gen Physiol	1977	300786	Yes
1840	1165	1165.0	74.92	74.9	Conservation of resources. A new attempt at conceptualizing stress.	S E Hobfoll	Am Psychol	1989	2648906	No
1841	1165	1165.0	32.65	32.6	Two pathogenetic types of endometrial carcinoma.	J V Bokhman	Gynecol Oncol	1983	6822361	Yes
1842	1165	1165.0	68.89	68.9	The biology and function of fibroblasts in cancer.	Raghu Kalluri	Nat Rev Cancer	2016	27550820	No
1843	1164	1164.0	60.94	60.9	A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability.	D J Schuirmann	J Pharmacokinet Biopharm	1987	3450848	Yes
1844	1164	1164.0	0.0	0.0	RNA-dependent DNA polymerase in virions of RNA tumour viruses.	D Baltimore	Nature	1970	4316300	Yes
1845	3492	1164.0	0.0	0.0	A rapid method for the isolation of functional thymus-derived murine lymphocytes.	M H Julius, E Simpson, L A Herzenberg	Eur J Immunol	1973	4587740	Yes
1846	1164	1164.0	31.67	31.7	Regulation of differentiation of vascular smooth muscle cells.	G K Owens	Physiol Rev	1995	7624392	No
1847	2328	1164.0	62.2	31.1	Multipoint quantitative-trait linkage analysis in general pedigrees.	L Almasy, J Blangero	Am J Hum Genet	1998	9545414	Yes
1848	1164	1164.0	27.6	27.6	Cancer of the ovary.	Stephen A Cannistra	N Engl J Med	2004	15590954	No
1849	1164	1164.0	75.62	75.6	Deep learning in neural networks: an overview.	Jürgen Schmidhuber	Neural Netw	2015	25462637	No
1850	3491	1163.7	111.35	37.1	I-TASSER: a unified platform for automated protein structure and function prediction.	Ambrish Roy, Alper Kucukural, Yang Zhang	Nat Protoc	2010	20360767	Yes
1851	1163	1163.0	63.03	63.0	Neurogenetic adaptive mechanisms in alcoholism.	C R Cloninger	Science	1987	2882604	Yes
1852	2326	1163.0	59.11	29.6	An essential role for NF-kappaB in preventing TNF-alpha-induced cell death.	A A Beg, D Baltimore	Science	1996	8864118	Yes
1853	2326	1163.0	44.09	22.0	Rab proteins as membrane organizers.	M Zerial, H McBride	Nat Rev Mol Cell Biol	2001	11252952	No
1854	1163	1163.0	0.0	0.0	Application of a microtechnique to viral serological investigations.	J L SEVER	J Immunol	1962	13910995	Yes
1855	2325	1162.5	104.73	52.4	The Oswestry Disability Index.	J C Fairbank, P B Pynsent	Spine (Phila Pa 1976)	2000	11074683	No
1856	1162	1162.0	33.68	33.7	Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule.	G von Heijne	J Mol Biol	1992	1593632	Yes
1857	2324	1162.0	69.71	34.9	Molecular mechanisms of long noncoding RNAs.	Kevin C Wang, Howard Y Chang	Mol Cell	2011	21925379	No
1858	2323	1161.5	94.76	47.4	Measuring emotion: the Self-Assessment Manikin and the Semantic Differential.	M M Bradley, P J Lang	J Behav Ther Exp Psychiatry	1994	7962581	Yes
1859	1161	1161.0	44.67	44.7	G proteins and dual control of adenylate cyclase.	A G Gilman	Cell	1984	6321035	Yes
1860	2321	1160.5	78.0	39.0	Astrocytes: biology and pathology.	Michael V Sofroniew, Harry V Vinters	Acta Neuropathol	2010	20012068	No
1861	1160	1160.0	34.13	34.1	Genetic consequences of climatic oscillations in the Quaternary.	G M Hewitt	Philos Trans R Soc Lond B Biol Sci	2004	15101575	No
1862	1160	1160.0	25.63	25.6	Maintenance of C. elegans.	Theresa Stiernagle	WormBook	2006	18050451	No
1863	2319	1159.5	84.13	42.1	The pathogenesis of rheumatoid arthritis.	Iain B McInnes, Georg Schett	N Engl J Med	2011	22150039	No
1864	2318	1159.0	82.77	41.4	Biochemistry of multidrug resistance mediated by the multidrug transporter.	M M Gottesman, I Pastan	Annu Rev Biochem	1993	8102521	No
1865	2317	1158.5	54.12	27.1	LTP and LTD: an embarrassment of riches.	Robert C Malenka, Mark F Bear	Neuron	2004	15450156	No
1866	1158	1158.0	0.0	0.0	Microbial ecology of the gastrointestinal tract.	D C Savage	Annu Rev Microbiol	1977	334036	No
1867	1158	1158.0	27.01	27.0	Drug discovery: a historical perspective.	J Drews	Science	2000	10720314	No
1868	2313	1156.5	87.82	43.9	Performing the exact test of Hardy-Weinberg proportion for multiple alleles.	S W Guo, E A Thompson	Biometrics	1992	1637966	Yes
1869	2311	1155.5	53.75	26.9	Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry.	Joshua E Elias, Steven P Gygi	Nat Methods	2007	17327847	Yes
1870	6931	1155.2	269.32	44.9	TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions.	Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg	Genome Biol	2013	23618408	Yes
1871	1155	1155.0	0.0	0.0	Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle.	A Fleckenstein	Annu Rev Pharmacol Toxicol	1977	326161	No
1872	1155	1155.0	35.12	35.1	The importance of the ratio of omega-6/omega-3 essential fatty acids.	A P Simopoulos	Biomed Pharmacother	2002	12442909	No
1873	1155	1155.0	29.9	29.9	Refined structure of the nicotinic acetylcholine receptor at 4A resolution.	Nigel Unwin	J Mol Biol	2005	15701510	Yes
1874	2308	1154.0	86.12	43.1	Functional architecture of basal ganglia circuits: neural substrates of parallel processing.	G E Alexander, M D Crutcher	Trends Neurosci	1990	1695401	No
1875	1154	1154.0	38.0	38.0	Redox signaling: nitrosylation and related target interactions of nitric oxide.	J S Stamler	Cell	1994	7923362	No
1876	1154	1154.0	20.27	20.3	The economics of ribosome biosynthesis in yeast.	J R Warner	Trends Biochem Sci	1999	10542411	No
1877	1154	1154.0	34.36	34.4	Hemispheric asymmetry reduction in older adults: the HAROLD model.	Roberto Cabeza	Psychol Aging	2002	11931290	No
1878	1154	1154.0	36.06	36.1	Synergy, antagonism, and what the chequerboard puts between them.	F C Odds	J Antimicrob Chemother	2003	12805255	No
1879	1154	1154.0	31.98	32.0	Marine viruses--major players in the global ecosystem.	Curtis A Suttle	Nat Rev Microbiol	2007	17853907	No
1880	2307	1153.5	47.56	23.8	Autophagy as a regulated pathway of cellular degradation.	D J Klionsky, S D Emr	Science	2000	11099404	No
1881	2306	1153.0	0.0	0.0	The structure of coping.	L I Pearlin, C Schooler	J Health Soc Behav	1978	649936	Yes
1882	1153	1153.0	57.33	57.3	A structured interview guide for the Hamilton Depression Rating Scale.	J B Williams	Arch Gen Psychiatry	1988	3395203	Yes
1883	2306	1153.0	0.0	0.0	New Giemsa method for the differential staining of sister chromatids.	P Perry, S Wolff	Nature	1974	4138930	Yes
1884	1153	1153.0	30.51	30.5	Upconversion and anti-Stokes processes with f and d ions in solids.	François Auzel	Chem Rev	2004	14719973	Yes
1885	1152	1152.0	0.0	0.0	Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection.	W H Oldendorf	Am J Physiol	1971	5124307	Yes
1886	1152	1152.0	50.15	50.1	Frontal-subcortical circuits and human behavior.	J L Cummings	Arch Neurol	1993	8352676	No
1887	1152	1152.0	0.0	0.0	CHROMATOGRAPHIC SEPARATION OF HUMAN BRAIN GANGLIOSIDES.	L SVENNERHOLM	J Neurochem	1963	14066623	Yes
1888	1152	1152.0	46.46	46.5	Asthma phenotypes: the evolution from clinical to molecular approaches.	Sally E Wenzel	Nat Med	2012	22561835	No
1889	1151	1151.0	45.48	45.5	The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate.	G R Buettner	Arch Biochem Biophys	1993	8434935	No
1890	2301	1150.5	68.85	34.4	The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.	P Angel, M Karin	Biochim Biophys Acta	1991	1751545	No
1891	2300	1150.0	58.64	29.3	The DNA damage response: making it safe to play with knives.	Alberto Ciccia, Stephen J Elledge	Mol Cell	2010	20965415	No
1892	1149	1149.0	37.25	37.2	Capacitative calcium entry revisited.	J W Putney	Cell Calcium	1990	1965707	No
1893	2298	1149.0	0.0	0.0	The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent.	A E Bolton, W M Hunter	Biochem J	1973	4733239	Yes
1894	1149	1149.0	32.02	32.0	Drug-induced prolongation of the QT interval.	Dan M Roden	N Engl J Med	2004	14999113	No
1895	1148	1148.0	40.54	40.5	Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum.	A Fabiato	Am J Physiol	1983	6346892	No
1896	2296	1148.0	52.79	26.4	Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.	J M Kyriakis, J Avruch	Physiol Rev	2001	11274345	No
1897	1147	1147.0	31.4	31.4	Functions of ceramide in coordinating cellular responses to stress.	Y A Hannun	Science	1996	8943189	No
1898	2293	1146.5	75.02	37.5	Bronchopulmonary dysplasia.	A H Jobe, E Bancalari	Am J Respir Crit Care Med	2001	11401896	No
1899	2293	1146.5	54.79	27.4	Cellular senescence: when bad things happen to good cells.	Judith Campisi, Fabrizio d'Adda di Fagagna	Nat Rev Mol Cell Biol	2007	17667954	No
1900	1146	1146.0	37.63	37.6	Molecular bases of the acute coronary syndromes.	P Libby	Circulation	1995	7758192	No
1901	1146	1146.0	22.19	22.2	Regulatory T cells: key controllers of immunologic self-tolerance.	S Sakaguchi	Cell	2000	10850488	No
1902	8020	1145.7	417.87	59.7	limma powers differential expression analyses for RNA-sequencing and microarray studies.	Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth	Nucleic Acids Res	2015	25605792	Yes
1903	2291	1145.5	0.0	0.0	Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.	A J Berk, P A Sharp	Cell	1977	922889	Yes
1904	2290	1145.0	0.0	0.0	A scaled version of the General Health Questionnaire.	D P Goldberg, V F Hillier	Psychol Med	1979	424481	Yes
1905	1145	1145.0	51.24	51.2	Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes.	C E Mogensen	N Engl J Med	1984	6690964	Yes
1906	1145	1145.0	33.71	33.7	Understanding biofilm resistance to antibacterial agents.	David Davies	Nat Rev Drug Discov	2003	12563302	No
1907	2290	1145.0	66.64	33.3	Abdominal obesity and metabolic syndrome.	Jean-Pierre Després, Isabelle Lemieux	Nature	2006	17167477	No
1908	2289	1144.5	63.88	31.9	Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering.	M P Lutolf, J A Hubbell	Nat Biotechnol	2005	15637621	No
1909	2288	1144.0	71.56	35.8	The expanding universe of T-cell subsets: Th1, Th2 and more.	T R Mosmann, S Sad	Immunol Today	1996	8820272	No
1910	2288	1144.0	61.64	30.8	NF-kappa B: ten years after.	P A Baeuerle, D Baltimore	Cell	1996	8858144	No
1911	1144	1144.0	19.64	19.6	Cancer. Addiction to oncogenes--the Achilles heal of cancer.	I Bernard Weinstein	Science	2002	12098689	No
1912	2286	1143.0	0.0	0.0	Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.	M Grunstein, D S Hogness	Proc Natl Acad Sci U S A	1975	1105573	Yes
1913	2286	1143.0	0.0	0.0	Computed circular dichroism spectra for the evaluation of protein conformation.	N Greenfield, G D Fasman	Biochemistry	1969	5346390	Yes
1914	2286	1143.0	69.65	34.8	Molecular replacement with MOLREP.	Alexei Vagin, Alexei Teplyakov	Acta Crystallogr D Biol Crystallogr	2010	20057045	Yes
1915	1142	1142.0	48.34	48.3	The self-medication hypothesis of substance use disorders: a reconsideration and recent applications.	E J Khantzian	Harv Rev Psychiatry	1997	9385000	No
1916	1142	1142.0	0.0	0.0	The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models.	R C Lewontin	Genetics	1964	17248194	Yes
1917	2283	1141.5	74.4	37.2	CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure.	Mattias Jakobsson, Noah A Rosenberg	Bioinformatics	2007	17485429	Yes
1918	1140	1140.0	38.72	38.7	Treatment of infections associated with surgical implants.	Rabih O Darouiche	N Engl J Med	2004	15070792	No
1919	3420	1140.0	145.61	48.5	CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting.	Teresa C Horan, Mary Andrus, Margaret A Dudeck	Am J Infect Control	2008	18538699	No
1920	1140	1140.0	42.4	42.4	Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations.	Chao-Jun Li	Acc Chem Res	2009	19220064	Yes
1921	1140	1140.0	48.31	48.3	Phase retrieval algorithms: a comparison.	J R Fienup	Appl Opt	1982	20396114	Yes
1922	4557	1139.2	216.36	54.1	Bayesian phylogenetics with BEAUti and the BEAST 1.7.	Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew Rambaut	Mol Biol Evol	2012	22367748	Yes
1923	1139	1139.0	36.72	36.7	A more meaningful scoring system for determining the severity of coronary heart disease.	G G Gensini	Am J Cardiol	1983	6823874	Yes
1924	2277	1138.5	98.44	49.2	Thermodynamics of protein association reactions: forces contributing to stability.	P D Ross, S Subramanian	Biochemistry	1981	7248271	Yes
1925	2277	1138.5	61.93	31.0	Interneurons of the hippocampus.	T F Freund, G Buzsáki	Hippocampus	1996	8915675	No
1926	1138	1138.0	0.0	0.0	Electroimmuno assay.	C B Laurell	Scand J Clin Lab Invest Suppl	1972	4114358	Yes
1927	1138	1138.0	25.59	25.6	The many faces of macrophage activation.	David M Mosser	J Leukoc Biol	2003	12554797	No
1928	3410	1136.7	103.99	34.7	How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.	R M Sapolsky, L M Romero, A U Munck	Endocr Rev	2000	10696570	No
1929	3410	1136.7	75.94	25.3	The versatility and universality of calcium signalling.	M J Berridge, P Lipp, M D Bootman	Nat Rev Mol Cell Biol	2000	11413485	No
1930	2273	1136.5	0.0	0.0	Junctional complexes in various epithelia.	M G FARQUHAR, G E PALADE	J Cell Biol	1963	13944428	Yes
1931	1136	1136.0	46.36	46.4	Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology.	N Krieger	Am J Public Health	1992	1566949	Yes
1932	2272	1136.0	0.0	0.0	A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.	J E TILL, E A McCULLOCH	Radiat Res	1961	13776896	Yes
1933	1136	1136.0	38.32	38.3	Understanding organofluorine chemistry. An introduction to the C-F bond.	David O'Hagan	Chem Soc Rev	2008	18197347	No
1934	2271	1135.5	50.85	25.4	The molecular biology of axon guidance.	M Tessier-Lavigne, C S Goodman	Science	1996	8895455	No
1935	2271	1135.5	73.47	36.7	Genome regulation by long noncoding RNAs.	John L Rinn, Howard Y Chang	Annu Rev Biochem	2012	22663078	No
1936	1135	1135.0	38.11	38.1	Circuitry and functional aspects of the insular lobe in primates including humans.	J R Augustine	Brain Res Brain Res Rev	1996	8957561	No
1937	1135	1135.0	23.41	23.4	NK cell receptors.	L L Lanier	Annu Rev Immunol	1998	9597134	No
1938	2269	1134.5	65.35	32.7	Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.	E S Lander, D Botstein	Genetics	1989	2563713	Yes
1939	2269	1134.5	74.0	37.0	Epidemiology of invasive candidiasis: a persistent public health problem.	M A Pfaller, D J Diekema	Clin Microbiol Rev	2007	17223626	No
1940	3403	1134.3	0.0	0.0	Hydroperoxide metabolism in mammalian organs.	B Chance, H Sies, A Boveris	Physiol Rev	1979	37532	Yes
1941	3403	1134.3	134.96	45.0	Global estimates of the prevalence of diabetes for 2010 and 2030.	J E Shaw, R A Sicree, P Z Zimmet	Diabetes Res Clin Pract	2010	19896746	Yes
1942	1134	1134.0	0.0	0.0	Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.	A Krishan	J Cell Biol	1975	49354	Yes
1943	1134	1134.0	44.83	44.8	Metalloproteinases and their inhibitors in matrix remodeling.	L M Matrisian	Trends Genet	1990	2132731	No
1944	1134	1134.0	0.0	0.0	The mechanism of muscular contraction.	H E Huxley	Science	1969	4181952	No
1945	1134	1134.0	27.45	27.4	The ATP synthase--a splendid molecular machine.	P D Boyer	Annu Rev Biochem	1997	9242922	No
1946	1134	1134.0	37.42	37.4	Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation.	P Willner	Psychopharmacology (Berl)	1997	9452163	No
1947	1134	1134.0	21.48	21.5	SUMO: a history of modification.	Ronald T Hay	Mol Cell	2005	15808504	No
1948	1134	1134.0	42.07	42.1	The law of attrition.	Gunther Eysenbach	J Med Internet Res	2005	15829473	Yes
1949	2267	1133.5	92.91	46.5	Genome editing. The new frontier of genome engineering with CRISPR-Cas9.	Jennifer A Doudna, Emmanuelle Charpentier	Science	2014	25430774	No
1950	2267	1133.5	168.57	84.3	Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees.	Ivica Letunic, Peer Bork	Nucleic Acids Res	2016	27095192	Yes
1951	2266	1133.0	62.58	31.3	Powering the planet: chemical challenges in solar energy utilization.	Nathan S Lewis, Daniel G Nocera	Proc Natl Acad Sci U S A	2006	17043226	Yes
1952	1133	1133.0	39.25	39.2	Chlorophyll fluorescence: a probe of photosynthesis in vivo.	Neil R Baker	Annu Rev Plant Biol	2008	18444897	No
1953	1133	1133.0	42.2	42.2	Aging, cellular senescence, and cancer.	Judith Campisi	Annu Rev Physiol	2013	23140366	No
1954	2265	1132.5	0.0	0.0	Synchronization of Plasmodium falciparum erythrocytic stages in culture.	C Lambros, J P Vanderberg	J Parasitol	1979	383936	Yes
1955	2264	1132.0	78.53	39.3	What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes.	J Zhang, K F Yu	JAMA	1998	9832001	Yes
1956	1132	1132.0	0.0	0.0	PLASTIC EMBEDDING MIXTURES FOR USE IN ELECTRON MICROSCOPY.	H H MOLLENHAUER	Stain Technol	1964	14127791	Yes
1957	1132	1132.0	32.82	32.8	The human orbitofrontal cortex: linking reward to hedonic experience.	Morten L Kringelbach	Nat Rev Neurosci	2005	16136173	No
1958	2264	1132.0	67.97	34.0	The gut microbiota shapes intestinal immune responses during health and disease.	June L Round, Sarkis K Mazmanian	Nat Rev Immunol	2009	19343057	No
1959	3395	1131.7	109.84	36.6	A rapid bootstrap algorithm for the RAxML Web servers.	Alexandros Stamatakis, Paul Hoover, Jacques Rougemont	Syst Biol	2008	18853362	Yes
1960	2263	1131.5	84.33	42.2	Polyamines.	C W Tabor, H Tabor	Annu Rev Biochem	1984	6206782	No
1961	7918	1131.1	270.42	38.6	Cancer statistics, 2008.	Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J Thun	CA Cancer J Clin	2008	18287387	Yes
1962	1131	1131.0	24.77	24.8	Natively unfolded proteins: a point where biology waits for physics.	Vladimir N Uversky	Protein Sci	2002	11910019	No
1963	2262	1131.0	63.34	31.7	A globally coherent fingerprint of climate change impacts across natural systems.	Camille Parmesan, Gary Yohe	Nature	2003	12511946	Yes
1964	1131	1131.0	31.31	31.3	The use of nanocrystals in biological detection.	Paul Alivisatos	Nat Biotechnol	2004	14704706	Yes
1965	1131	1131.0	44.37	44.4	Formation of glasses from liquids and biopolymers.	C A Angell	Science	1995	17770101	Yes
1966	1131	1131.0	32.41	32.4	Reconciling the chemistry and biology of reactive oxygen species.	Christine C Winterbourn	Nat Chem Biol	2008	18421291	No
1967	1131	1131.0	41.67	41.7	Stress and disorders of the stress system.	George P Chrousos	Nat Rev Endocrinol	2009	19488073	No
1968	1131	1131.0	44.19	44.2	Matching methods for causal inference: A review and a look forward.	Elizabeth A Stuart	Stat Sci	2010	20871802	Yes
1969	2262	1131.0	112.86	56.4	Natural products as sources of new drugs over the 30 years from 1981 to 2010.	David J Newman, Gordon M Cragg	J Nat Prod	2012	22316239	No
1970	2261	1130.5	64.98	32.5	The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity.	Clay B Holroyd, Michael G H Coles	Psychol Rev	2002	12374324	Yes
1971	2260	1130.0	45.63	22.8	Oncogenic kinase signalling.	P Blume-Jensen, T Hunter	Nature	2001	11357143	No
1972	2259	1129.5	55.24	27.6	Self-assembly at all scales.	George M Whitesides, Bartosz Grzybowski	Science	2002	11923529	Yes
1973	2259	1129.5	67.41	33.7	Regulation of chromatin by histone modifications.	Andrew J Bannister, Tony Kouzarides	Cell Res	2011	21321607	No
1974	4516	1129.0	157.27	39.3	Reversible middle cerebral artery occlusion without craniectomy in rats.	E Z Longa, P R Weinstein, S Carlson, R Cummins	Stroke	1989	2643202	Yes
1975	1129	1129.0	33.8	33.8	The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.	T Szkudelski	Physiol Res	2001	11829314	No
1976	1128	1128.0	0.0	0.0	Isolated removal of hypothalamic or other brain nuclei of the rat.	M Palkovits	Brain Res	1973	4747772	Yes
1977	2255	1127.5	81.34	40.7	Porosity of 3D biomaterial scaffolds and osteogenesis.	Vassilis Karageorgiou, David Kaplan	Biomaterials	2005	15860204	No
1978	1127	1127.0	0.0	0.0	Stimulated acoustic emissions from within the human auditory system.	D T Kemp	J Acoust Soc Am	1978	744838	Yes
1979	2254	1127.0	0.0	0.0	Convergent and discriminant validation by the multitrait-multimethod matrix.	D T CAMPBELL, D W FISKE	Psychol Bull	1959	13634291	Yes
1980	1127	1127.0	0.0	0.0	THE RELATION OF RECOMBINATION TO MUTATIONAL ADVANCE.	H J MULLER	Mutat Res	1964	14195748	Yes
1981	1127	1127.0	27.76	27.8	Mechanisms of foxp3+ T regulatory cell-mediated suppression.	Ethan M Shevach	Immunity	2009	19464986	No
1982	2254	1127.0	54.09	27.0	NMR View: A computer program for the visualization and analysis of NMR data.	B A Johnson, R A Blevins	J Biomol NMR	1994	22911360	Yes
1983	2253	1126.5	55.85	27.9	Cancer stem cells in solid tumours: accumulating evidence and unresolved questions.	Jane E Visvader, Geoffrey J Lindeman	Nat Rev Cancer	2008	18784658	No
1984	3378	1126.0	83.9	28.0	Telomeres shorten during ageing of human fibroblasts.	C B Harley, A B Futcher, C W Greider	Nature	1990	2342578	Yes
1985	1126	1126.0	37.03	37.0	Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects.	E B Hunziker	Osteoarthritis Cartilage	2002	12056848	No
1986	2252	1126.0	75.72	37.9	The cortical organization of speech processing.	Gregory Hickok, David Poeppel	Nat Rev Neurosci	2007	17431404	No
1987	2251	1125.5	63.9	31.9	The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes.	Daniel J Drucker, Michael A Nauck	Lancet	2006	17098089	No
1988	1125	1125.0	34.02	34.0	Rapid and sensitive sequence comparison with FASTP and FASTA.	W R Pearson	Methods Enzymol	1990	2156132	Yes
1989	1125	1125.0	50.4	50.4	Colorimetric determination of phospholipids with ammonium ferrothiocyanate.	J C Stewart	Anal Biochem	1980	6892980	Yes
1990	1125	1125.0	34.74	34.7	Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp.	D A Dougherty	Science	1996	8539615	No
1991	1125	1125.0	45.86	45.9	Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains.	K Anders Ericsson	Acad Med	2004	15383395	No
1992	1125	1125.0	31.17	31.2	Clinical features of metastatic bone disease and risk of skeletal morbidity.	Robert E Coleman	Clin Cancer Res	2006	17062708	No
1993	1125	1125.0	57.96	58.0	Whatever next? Predictive brains, situated agents, and the future of cognitive science.	Andy Clark	Behav Brain Sci	2013	23663408	No
1994	1124	1124.0	41.17	41.2	Osteoblast adhesion on biomaterials.	K Anselme	Biomaterials	2000	10711964	No
1995	1123	1123.0	56.57	56.6	Physiological aspects of primary hypertension.	B Folkow	Physiol Rev	1982	6461865	No
1996	1122	1122.0	25.33	25.3	Endocytosis and molecular sorting.	I Mellman	Annu Rev Cell Dev Biol	1996	8970738	No
1997	2244	1122.0	62.16	31.1	Molecular beacons: probes that fluoresce upon hybridization.	S Tyagi, F R Kramer	Nat Biotechnol	1996	9630890	Yes
1998	2242	1121.0	68.84	34.4	Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators.	I Issemann, S Green	Nature	1990	2129546	Yes
1999	2242	1121.0	97.32	48.7	Universal chemical assay for the detection and determination of siderophores.	B Schwyn, J B Neilands	Anal Biochem	1987	2952030	Yes
2000	1121	1121.0	0.0	0.0	The oxidation of ribonuclease with performic acid.	C H HIRS	J Biol Chem	1956	13319283	Yes
2001	1121	1121.0	0.0	0.0	Application of a Theory of Enzyme Specificity to Protein Synthesis.	D E Koshland	Proc Natl Acad Sci U S A	1958	16590179	Yes
2002	3362	1120.7	90.13	30.0	The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.	S K Hanks, A M Quinn, T Hunter	Science	1988	3291115	No
2003	3361	1120.3	86.43	28.8	Long non-coding RNAs: insights into functions.	Tim R Mercer, Marcel E Dinger, John S Mattick	Nat Rev Genet	2009	19188922	No
2004	2240	1120.0	82.51	41.3	The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.	J D Hayes, D J Pulford	Crit Rev Biochem Mol Biol	1995	8770536	No
2005	6711	1118.5	190.12	31.7	A default mode of brain function.	M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L Shulman	Proc Natl Acad Sci U S A	2001	11209064	Yes
2006	2237	1118.5	62.63	31.3	Cell signaling by receptor tyrosine kinases.	Mark A Lemmon, Joseph Schlessinger	Cell	2010	20602996	No
2007	3355	1118.3	90.85	30.3	Thresholding of statistical maps in functional neuroimaging using the false discovery rate.	Christopher R Genovese, Nicole A Lazar, Thomas Nichols	Neuroimage	2002	11906227	Yes
2008	1118	1118.0	58.34	58.3	Negative symptoms in schizophrenia. Definition and reliability.	N C Andreasen	Arch Gen Psychiatry	1982	7165477	Yes
2009	1117	1117.0	42.74	42.7	Neurotransmitters and neuromodulators in the basal ganglia.	A M Graybiel	Trends Neurosci	1990	1695398	No
2010	1117	1117.0	41.45	41.5	Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications.	M D Maines	FASEB J	1988	3290025	No
2011	1117	1117.0	30.25	30.2	The blood-brain barrier: bottleneck in brain drug development.	William M Pardridge	NeuroRx	2005	15717053	No
2012	1117	1117.0	32.58	32.6	The cancer stem cell: premises, promises and challenges.	Hans Clevers	Nat Med	2011	21386835	No
2013	1116	1116.0	26.98	27.0	HIF-1: mediator of physiological and pathophysiological responses to hypoxia.	G L Semenza	J Appl Physiol (1985)	2000	10749844	No
2014	1115	1115.0	32.58	32.6	Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides.	Y Shai	Biochim Biophys Acta	1999	10590302	No
2015	1115	1115.0	39.58	39.6	Signal transduction by reactive oxygen species.	Toren Finkel	J Cell Biol	2011	21746850	No
2016	1114	1114.0	0.0	0.0	Estimability and estimation in case-referent studies.	O Miettinen	Am J Epidemiol	1976	1251836	Yes
2017	2228	1114.0	76.97	38.5	Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9164317	Yes
2018	1114	1114.0	52.4	52.4	MorphoJ: an integrated software package for geometric morphometrics.	Christian Peter Klingenberg	Mol Ecol Resour	2011	21429143	Yes
2019	1114	1114.0	52.58	52.6	Cognitive reserve in ageing and Alzheimer's disease.	Yaakov Stern	Lancet Neurol	2012	23079557	No
2020	2227	1113.5	89.16	44.6	Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art.	Johan W S Vlaeyen, Steven J Linton	Pain	2000	10781906	No
2021	2227	1113.5	45.3	22.6	Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection.	C Li, W H Wong	Proc Natl Acad Sci U S A	2001	11134512	Yes
2022	1113	1113.0	30.17	30.2	Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?	Rui Wang	FASEB J	2002	12409322	Yes
2023	3338	1112.7	97.57	32.5	The metabolic syndrome.	Robert H Eckel, Scott M Grundy, Paul Z Zimmet	Lancet	2005	15836891	No
2024	1112	1112.0	20.89	20.9	The molecular motor toolbox for intracellular transport.	Ronald D Vale	Cell	2003	12600311	No
2025	1111	1111.0	0.0	0.0	DITHIOTHREITOL, A NEW PROTECTIVE REAGENT FOR SH GROUPS.	W W CLELAND	Biochemistry	1964	14192894	Yes
2026	1111	1111.0	24.44	24.4	The significance of responses of the genome to challenge.	B McClintock	Science	1984	15739260	No
2027	1111	1111.0	34.02	34.0	Adult mesenchymal stem cells for tissue engineering versus regenerative medicine.	Arnold I Caplan	J Cell Physiol	2007	17620285	No
2028	3331	1110.3	76.33	25.4	A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.	R Medzhitov, P Preston-Hurlburt, C A Janeway	Nature	1997	9237759	Yes
2029	2219	1109.5	0.0	0.0	THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.	T OMURA, R SATO	J Biol Chem	1964	14209972	Yes
2030	3328	1109.3	83.45	27.8	Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?	Witold Filipowicz, Suvendra N Bhattacharyya, Nahum Sonenberg	Nat Rev Genet	2008	18197166	No
2031	2217	1108.5	103.51	51.8	A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels.	C M Tsai, C E Frasch	Anal Biochem	1982	6176137	Yes
2032	1108	1108.0	32.84	32.8	Short-term synaptic plasticity.	R S Zucker	Annu Rev Neurosci	1989	2648947	No
2033	1108	1108.0	48.23	48.2	Functional organization of central pathways regulating the cardiovascular system.	R A Dampney	Physiol Rev	1994	8171117	No
2034	1108	1108.0	23.03	23.0	Protein kinases--the major drug targets of the twenty-first century?	Philip Cohen	Nat Rev Drug Discov	2002	12120282	No
2035	2215	1107.5	49.57	24.8	Regulated portals of entry into the cell.	Sean D Conner, Sandra L Schmid	Nature	2003	12621426	No
2036	1107	1107.0	20.17	20.2	Clonal selection and learning in the antibody system.	K Rajewsky	Nature	1996	8657279	No
2037	1107	1107.0	33.34	33.3	Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders.	R M Sapolsky	Arch Gen Psychiatry	2000	11015810	No
2038	1106	1106.0	34.64	34.6	Thioredoxin and glutaredoxin systems.	A Holmgren	J Biol Chem	1989	2668278	No
2039	2212	1106.0	101.26	50.6	The integrative review: updated methodology.	Robin Whittemore, Kathleen Knafl	J Adv Nurs	2005	16268861	Yes
2040	2211	1105.5	116.56	58.3	A new initiative on precision medicine.	Francis S Collins, Harold Varmus	N Engl J Med	2015	25635347	Yes
2041	1105	1105.0	30.83	30.8	The cadherins: cell-cell adhesion molecules controlling animal morphogenesis.	M Takeichi	Development	1988	3048970	No
2042	1105	1105.0	0.0	0.0	Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion.	S S Lehrer	Biochemistry	1971	5119250	Yes
2043	1105	1105.0	51.05	51.0	Presidential address, 1980. Surprise!...Surprise?	E Donchin	Psychophysiology	1981	7280146	Yes
2044	1105	1105.0	39.41	39.4	Chronic disease management: what will it take to improve care for chronic illness?	E H Wagner	Eff Clin Pract	1998	10345255	No
2045	2210	1105.0	0.0	0.0	The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.	E G GRAY, V P WHITTAKER	J Anat	1962	13901297	Yes
2046	8839	1104.9	249.82	31.2	Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain.	N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M Joliot	Neuroimage	2002	11771995	Yes
2047	2209	1104.5	45.82	22.9	Genetic transformation of Drosophila with transposable element vectors.	G M Rubin, A C Spradling	Science	1982	6289436	Yes
2048	1104	1104.0	54.05	54.0	The role of hormone receptors and GTP-regulatory proteins in membrane transduction.	M Rodbell	Nature	1980	6101906	Yes
2049	2207	1103.5	99.07	49.5	The need to belong: desire for interpersonal attachments as a fundamental human motivation.	R F Baumeister, M R Leary	Psychol Bull	1995	7777651	No
2050	5517	1103.4	188.21	37.6	Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication.	Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E Walters	Arch Gen Psychiatry	2005	15939839	Yes
2051	1103	1103.0	55.33	55.3	Reliability and factor analysis of the Epworth Sleepiness Scale.	M W Johns	Sleep	1992	1519015	Yes
2052	1103	1103.0	34.72	34.7	The origins of the developmental origins theory.	D J P Barker	J Intern Med	2007	17444880	No
2053	6614	1102.3	209.47	34.9	Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.	Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur Wheeler	N Engl J Med	2000	10793162	Yes
2054	2204	1102.0	53.85	26.9	Escaping free-energy minima.	Alessandro Laio, Michele Parrinello	Proc Natl Acad Sci U S A	2002	12271136	Yes
2055	2203	1101.5	74.93	37.5	Mortality by cause for eight regions of the world: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9142060	Yes
2056	1101	1101.0	27.42	27.4	E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.	J R Nevins	Science	1992	1411535	Yes
2057	3303	1101.0	95.18	31.7	Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.	M A Frohman, M K Dush, G R Martin	Proc Natl Acad Sci U S A	1988	2461560	Yes
2058	2202	1101.0	72.53	36.3	Transforming growth factor beta in tissue fibrosis.	W A Border, N A Noble	N Engl J Med	1994	7935686	No
2059	1101	1101.0	21.99	22.0	Mobile elements: drivers of genome evolution.	Haig H Kazazian	Science	2004	15016989	No
2060	3301	1100.3	60.78	20.3	A system for stable expression of short interfering RNAs in mammalian cells.	Thijn R Brummelkamp, René Bernards, Reuven Agami	Science	2002	11910072	Yes
2061	1100	1100.0	29.89	29.9	Developmental cell death: morphological diversity and multiple mechanisms.	P G Clarke	Anat Embryol (Berl)	1990	2186664	No
2062	1100	1100.0	30.51	30.5	Proinflammatory cytokines.	C A Dinarello	Chest	2000	10936147	No
2063	1100	1100.0	21.78	21.8	microRNAs: tiny regulators with great potential.	V Ambros	Cell	2001	11779458	No
2064	1099	1099.0	40.45	40.5	Biological basis of the behavior of sick animals.	B L Hart	Neurosci Biobehav Rev	1988	3050629	No
2065	1099	1099.0	47.21	47.2	Metallothionein.	D H Hamer	Annu Rev Biochem	1986	3527054	No
2066	1099	1099.0	45.4	45.4	Plasma perspective on strong field multiphoton ionization.	Corkum	Phys Rev Lett	1993	10054556	Yes
2067	1099	1099.0	34.52	34.5	The sympathetic control of blood pressure.	Patrice G Guyenet	Nat Rev Neurosci	2006	16760914	No
2068	1099	1099.0	26.74	26.7	DNA damage, aging, and cancer.	Jan H J Hoeijmakers	N Engl J Med	2009	19812404	No
2069	3296	1098.7	103.04	34.3	Atomic force microscope.	Binnig, Quate, Gerber	Phys Rev Lett	1986	10033323	Yes
2070	2197	1098.5	46.18	23.1	Prediction of complete gene structures in human genomic DNA.	C Burge, S Karlin	J Mol Biol	1997	9149143	Yes
2071	1098	1098.0	0.0	0.0	The biologic clock: the mitochondria?	D Harman	J Am Geriatr Soc	1972	5016631	Yes
2072	2194	1097.0	0.0	0.0	Mutations of Bacteria from Virus Sensitivity to Virus Resistance.	S E Luria, M Delbrück	Genetics	1943	17247100	Yes
2073	3290	1096.7	139.5	46.5	A new method for off-line removal of ocular artifact.	G Gratton, M G Coles, E Donchin	Electroencephalogr Clin Neurophysiol	1983	6187540	Yes
2074	12061	1096.5	334.74	30.4	New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada.	P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G Gwyther	J Natl Cancer Inst	2000	10655437	No
2075	1096	1096.0	25.49	25.5	The stem-cell niche as an entity of action.	David T Scadden	Nature	2006	16810242	No
2076	4383	1095.8	114.01	28.5	Quantitative monitoring of gene expression patterns with a complementary DNA microarray.	M Schena, D Shalon, R W Davis, P O Brown	Science	1995	7569999	Yes
2077	2191	1095.5	50.66	25.3	Liver regeneration.	G K Michalopoulos, M C DeFrances	Science	1997	9082986	No
2078	2190	1095.0	75.32	37.7	Angiogenesis.	J Folkman, Y Shing	J Biol Chem	1992	1375931	No
2079	1095	1095.0	44.26	44.3	Glutathione metabolism and its selective modification.	A Meister	J Biol Chem	1988	3053703	No
2080	1095	1095.0	21.08	21.1	c-Myc target genes involved in cell growth, apoptosis, and metabolism.	C V Dang	Mol Cell Biol	1999	9858526	No
2081	1095	1095.0	35.13	35.1	Diagnosis of osteoporosis and assessment of fracture risk.	John A Kanis	Lancet	2002	12057569	No
2082	2189	1094.5	80.27	40.1	Oxidative stress and diabetic complications.	Ferdinando Giacco, Michael Brownlee	Circ Res	2010	21030723	No
2083	1094	1094.0	0.0	0.0	Codon--anticodon pairing: the wobble hypothesis.	F H Crick	J Mol Biol	1966	5969078	Yes
2084	1094	1094.0	43.92	43.9	Turnover of inositol phospholipids and signal transduction.	Y Nishizuka	Science	1984	6147898	No
2085	1094	1094.0	44.61	44.6	Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data.	Thomas Heberer	Toxicol Lett	2002	11988354	Yes
2086	1094	1094.0	35.85	35.9	Multiple imputation of discrete and continuous data by fully conditional specification.	Stef van Buuren	Stat Methods Med Res	2007	17621469	Yes
2087	1093	1093.0	46.4	46.4	Recent advances in the biochemistry of polyamines in eukaryotes.	A E Pegg	Biochem J	1986	3087344	No
2088	1093	1093.0	29.03	29.0	Functions of the neurotrophins during nervous system development: what the knockouts are teaching us.	W D Snider	Cell	1994	8205613	No
2089	1093	1093.0	29.51	29.5	Optimal experimental design for event-related fMRI.	A M Dale	Hum Brain Mapp	1999	10524601	Yes
2090	2186	1093.0	56.94	28.5	Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits.	Kornelia Polyak, Robert A Weinberg	Nat Rev Cancer	2009	19262571	No
2091	4371	1092.8	0.0	0.0	A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples.	M A Markwell, S M Haas, L L Bieber, N E Tolbert	Anal Biochem	1978	98070	Yes
2092	2185	1092.5	79.75	39.9	Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India.	D Filmer, L H Pritchett	Demography	2001	11227840	Yes
2093	1092	1092.0	0.0	0.0	Biological applications of ionophores.	B C Pressman	Annu Rev Biochem	1976	786156	No
2094	2184	1092.0	78.48	39.2	An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat.	Sun Ho Kim, Jin Mo Chung	Pain	1992	1333581	Yes
2095	1092	1092.0	0.0	0.0	Hippocampal electrical activity and voluntary movement in the rat.	C H Vanderwolf	Electroencephalogr Clin Neurophysiol	1969	4183562	Yes
2096	1092	1092.0	0.0	0.0	A soluble protein characteristic of the nervous system.	B W Moore	Biochem Biophys Res Commun	1965	4953930	Yes
2097	2183	1091.5	54.98	27.5	Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins.	P J Mitchell, R Tjian	Science	1989	2667136	No
2098	1091	1091.0	0.0	0.0	CHEMOAFFINITY IN THE ORDERLY GROWTH OF NERVE FIBER PATTERNS AND CONNECTIONS.	R W SPERRY	Proc Natl Acad Sci U S A	1963	14077501	Yes
2099	1091	1091.0	28.84	28.8	Fast and robust fixed-point algorithms for independent component analysis.	A Hyvärinen	IEEE Trans Neural Netw	1999	18252563	Yes
2100	2181	1090.5	61.22	30.6	Pharmacology and functions of metabotropic glutamate receptors.	P J Conn, J P Pin	Annu Rev Pharmacol Toxicol	1997	9131252	No
2101	1090	1090.0	41.17	41.2	Ordinary magic. Resilience processes in development.	A S Masten	Am Psychol	2001	11315249	Yes
2102	1090	1090.0	26.17	26.2	Transcriptional control of adipocyte formation.	Stephen R Farmer	Cell Metab	2006	17011499	No
2103	3269	1089.7	78.05	26.0	OrthoMCL: identification of ortholog groups for eukaryotic genomes.	Li Li, Christian J Stoeckert, David S Roos	Genome Res	2003	12952885	Yes
2104	1089	1089.0	45.73	45.7	The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria.	A Raine	Schizophr Bull	1991	1805349	Yes
2105	1089	1089.0	55.28	55.3	The validity and practicality of sun-reactive skin types I through VI.	T B Fitzpatrick	Arch Dermatol	1988	3377516	Yes
2106	1089	1089.0	0.0	0.0	The statistical analysis of enzyme kinetic data.	W W Cleland	Adv Enzymol Relat Areas Mol Biol	1967	4881884	No
2107	2178	1089.0	70.63	35.3	Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis.	F D Lublin, S C Reingold	Neurology	1996	8780061	Yes
2108	1089	1089.0	30.71	30.7	Tobacco smoke carcinogens and lung cancer.	S S Hecht	J Natl Cancer Inst	1999	10413421	No
2109	1089	1089.0	44.14	44.1	Inflammation in atherosclerosis.	Peter Libby	Arterioscler Thromb Vasc Biol	2012	22895665	No
2110	4353	1088.2	94.56	23.6	Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.	D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini	Science	2005	15718470	Yes
2111	2176	1088.0	58.08	29.0	The MAPK signaling cascade.	R Seger, E G Krebs	FASEB J	1995	7601337	No
2112	1088	1088.0	22.01	22.0	CD95's deadly mission in the immune system.	P H Krammer	Nature	2000	11048730	No
2113	2176	1088.0	52.01	26.0	The pathophysiology of mitochondrial cell death.	Douglas R Green, Guido Kroemer	Science	2004	15286356	No
2114	1088	1088.0	26.22	26.2	Topoisomerase I inhibitors: camptothecins and beyond.	Yves Pommier	Nat Rev Cancer	2006	16990856	No
2115	2175	1087.5	68.44	34.2	What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?	K C Berridge, T E Robinson	Brain Res Brain Res Rev	1998	9858756	No
2116	2175	1087.5	58.98	29.5	Regulation mechanisms and signaling pathways of autophagy.	Congcong He, Daniel J Klionsky	Annu Rev Genet	2009	19653858	No
2117	5435	1087.0	156.13	31.2	Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies.	Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory Collins	Lancet	2002	12493255	Yes
2118	2174	1087.0	189.17	94.6	Natural Products as Sources of New Drugs from 1981 to 2014.	David J Newman, Gordon M Cragg	J Nat Prod	2016	26852623	No
2119	3260	1086.7	76.96	25.7	Multidrug resistance in cancer: role of ATP-dependent transporters.	Michael M Gottesman, Tito Fojo, Susan E Bates	Nat Rev Cancer	2002	11902585	No
2120	2173	1086.5	56.99	28.5	The RXR heterodimers and orphan receptors.	D J Mangelsdorf, R M Evans	Cell	1995	8521508	No
2121	1086	1086.0	31.23	31.2	Microbial influences in inflammatory bowel diseases.	R Balfour Sartor	Gastroenterology	2008	18242222	No
2122	1086	1086.0	46.59	46.6	Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models.	T Florian Jaeger	J Mem Lang	2008	19884961	Yes
2123	1085	1085.0	42.06	42.1	Equipoise and the ethics of clinical research.	B Freedman	N Engl J Med	1987	3600702	Yes
2124	2170	1085.0	90.33	45.2	How useful is SBF in predicting in vivo bone bioactivity?	Tadashi Kokubo, Hiroaki Takadama	Biomaterials	2006	16448693	No
2125	1084	1084.0	74.29	74.3	Presynaptic regulation of the release of catecholamines.	S Z Langer	Pharmacol Rev	1980	6267618	Yes
2126	1083	1083.0	59.37	59.4	Mood and memory.	G H Bower	Am Psychol	1981	7224324	Yes
2127	1083	1083.0	0.0	0.0	Diversity in tropical rain forests and coral reefs.	J H Connell	Science	1978	17840770	Yes
2128	1082	1082.0	28.6	28.6	Codon usage and tRNA content in unicellular and multicellular organisms.	T Ikemura	Mol Biol Evol	1985	3916708	No
2129	1082	1082.0	28.59	28.6	Protein kinase C: structure, function, and regulation.	A C Newton	J Biol Chem	1995	7499357	No
2130	2163	1081.5	0.0	0.0	3' non-coding region sequences in eukaryotic messenger RNA.	N J Proudfoot, G G Brownlee	Nature	1976	822353	Yes
2131	1081	1081.0	29.38	29.4	Reactive oxygen radicals in signaling and damage in the ischemic brain.	P H Chan	J Cereb Blood Flow Metab	2001	11149664	No
2132	1081	1081.0	39.53	39.5	A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation.	Ozcan Erel	Clin Biochem	2004	15003729	Yes
2133	2161	1080.5	42.02	21.0	DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.	Christopher J Bakkenist, Michael B Kastan	Nature	2003	12556884	Yes
2134	1080	1080.0	0.0	0.0	Some observations upon a new inhibitor of monoamine oxidase in brain tissue.	J P Johnston	Biochem Pharmacol	1968	5659776	Yes
2135	1080	1080.0	0.0	0.0	A graphic method for the determination and presentation of binding parameters in a complex system.	H E Rosenthal	Anal Biochem	1967	6048188	Yes
2136	1080	1080.0	26.04	26.0	Long-term potentiation and memory.	M A Lynch	Physiol Rev	2004	14715912	No
2137	1080	1080.0	59.58	59.6	Optical properties of biological tissues: a review.	Steven L Jacques	Phys Med Biol	2013	23666068	No
2138	2158	1079.0	79.41	39.7	Glycine potentiates the NMDA response in cultured mouse brain neurons.	J W Johnson, P Ascher	Nature	1987	2433595	Yes
2139	2158	1079.0	53.98	27.0	Mitochondrial control of cell death.	G Kroemer, J C Reed	Nat Med	2000	10802706	No
2140	1079	1079.0	43.99	44.0	SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test.	B P O'Connor	Behav Res Methods Instrum Comput	2000	11029811	Yes
2141	1079	1079.0	44.0	44.0	The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme.	Poul Erik Petersen	Community Dent Oral Epidemiol	2003	15015736	Yes
2142	3236	1078.7	70.99	23.7	Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM).	Michael J Rust, Mark Bates, Xiaowei Zhuang	Nat Methods	2006	16896339	Yes
2143	2157	1078.5	67.31	33.7	Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies.	Robert E W Hancock, Hans-Georg Sahl	Nat Biotechnol	2006	17160061	No
2144	1078	1078.0	0.0	0.0	Bias in analytic research.	D L Sackett	J Chronic Dis	1979	447779	Yes
2145	1078	1078.0	29.55	29.6	The 'effective number of codons' used in a gene.	F Wright	Gene	1990	2110097	Yes
2146	1078	1078.0	27.39	27.4	Ordered porous materials for emerging applications.	Mark E Davis	Nature	2002	12075343	No
2147	2155	1077.5	46.49	23.2	Gene silencing in cancer in association with promoter hypermethylation.	James G Herman, Stephen B Baylin	N Engl J Med	2003	14627790	No
2148	2154	1077.0	58.6	29.3	Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface.	D A Brown, J K Rose	Cell	1992	1531449	Yes
2149	3230	1076.7	112.48	37.5	Simultaneous inference in general parametric models.	Torsten Hothorn, Frank Bretz, Peter Westfall	Biom J	2008	18481363	No
2150	2153	1076.5	62.52	31.3	Neuronal plasticity: increasing the gain in pain.	C J Woolf, M W Salter	Science	2000	10846153	No
2151	2151	1075.5	0.0	0.0	Empirical predictions of protein conformation.	P Y Chou, G D Fasman	Annu Rev Biochem	1978	354496	No
2152	2151	1075.5	42.53	21.3	Live or let die: the cell's response to p53.	Karen H Vousden, Xin Lu	Nat Rev Cancer	2002	12154352	No
2153	2151	1075.5	93.43	46.7	Van der Waals heterostructures.	A K Geim, I V Grigorieva	Nature	2013	23887427	Yes
2154	1075	1075.0	30.89	30.9	Pain and emotion interactions in subregions of the cingulate gyrus.	Brent A Vogt	Nat Rev Neurosci	2005	15995724	No
2155	1075	1075.0	37.45	37.5	Recent developments in isocyanide based multicomponent reactions in applied chemistry.	Alexander Dömling	Chem Rev	2006	16402771	No
2156	2147	1073.5	42.65	21.3	A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback.	D Tautz, C Pfeifle	Chromosoma	1989	2476281	Yes
2157	2146	1073.0	83.34	41.7	Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.	D S Bredt, S H Snyder	Proc Natl Acad Sci U S A	1990	1689048	Yes
2158	1073	1073.0	60.92	60.9	A new international staging system for lung cancer.	C F Mountain	Chest	1986	3514171	No
2159	1073	1073.0	52.8	52.8	KDIGO clinical practice guidelines for acute kidney injury.	Arif Khwaja	Nephron Clin Pract	2012	22890468	No
2160	3217	1072.3	90.46	30.2	Membrane lipids: where they are and how they behave.	Gerrit van Meer, Dennis R Voelker, Gerald W Feigenson	Nat Rev Mol Cell Biol	2008	18216768	No
2161	3216	1072.0	83.96	28.0	Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides.	Christian W Tornøe, Caspar Christensen, Morten Meldal	J Org Chem	2002	11975567	Yes
2162	1072	1072.0	0.0	0.0	Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid.	W C SCHNEIDER	J Biol Chem	1945	21005736	Yes
2163	4287	1071.8	107.63	26.9	Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.	Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J Thun	N Engl J Med	2003	12711737	Yes
2164	1071	1071.0	40.21	40.2	Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia.	A A Grace	Neuroscience	1991	1676137	No
2165	3213	1071.0	83.76	27.9	Tissue cells feel and respond to the stiffness of their substrate.	Dennis E Discher, Paul Janmey, Yu-Li Wang	Science	2005	16293750	No
2166	2142	1071.0	44.6	22.3	A general framework for weighted gene co-expression network analysis.	Bin Zhang, Steve Horvath	Stat Appl Genet Mol Biol	2005	16646834	Yes
2167	1071	1071.0	32.66	32.7	Atopic dermatitis.	Thomas Bieber	N Engl J Med	2008	18385500	Yes
2168	2141	1070.5	90.76	45.4	The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today.	R Doll, R Peto	J Natl Cancer Inst	1981	7017215	No
2169	1070	1070.0	38.19	38.2	Integrins.	E Ruoslahti	J Clin Invest	1991	1985087	No
2170	1070	1070.0	25.27	25.3	Dimerization of cell surface receptors in signal transduction.	C H Heldin	Cell	1995	7834741	No
2171	1070	1070.0	28.08	28.1	Pathways of oxidative damage.	James A Imlay	Annu Rev Microbiol	2003	14527285	No
2172	2140	1070.0	62.16	31.1	ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins.	Markus Wiederstein, Manfred J Sippl	Nucleic Acids Res	2007	17517781	Yes
2173	2137	1068.5	58.72	29.4	Microglia: active sensor and versatile effector cells in the normal and pathologic brain.	Uwe-Karsten Hanisch, Helmut Kettenmann	Nat Neurosci	2007	17965659	No
2174	1068	1068.0	51.63	51.6	An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results.	J Kabat-Zinn	Gen Hosp Psychiatry	1982	7042457	Yes
2175	2136	1068.0	76.33	38.2	The benefits of being present: mindfulness and its role in psychological well-being.	Kirk Warren Brown, Richard M Ryan	J Pers Soc Psychol	2003	12703651	Yes
2176	3204	1068.0	73.23	24.4	Calcium signalling: dynamics, homeostasis and remodelling.	Michael J Berridge, Martin D Bootman, H Llewelyn Roderick	Nat Rev Mol Cell Biol	2003	12838335	No
2177	2135	1067.5	55.01	27.5	Long short-term memory.	S Hochreiter, J Schmidhuber	Neural Comput	1997	9377276	Yes
2178	1067	1067.0	32.95	33.0	Speculations on the functions of the major heat shock and glucose-regulated proteins.	H R Pelham	Cell	1986	2944601	Yes
2179	2134	1067.0	59.64	29.8	Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information.	M Zuker, P Stiegler	Nucleic Acids Res	1981	6163133	Yes
2180	1067	1067.0	24.46	24.5	Searching for genetic determinants in the new millennium.	N J Risch	Nature	2000	10866211	No
2181	11729	1066.3	381.59	34.7	The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.	Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J Roccella	JAMA	2003	12748199	No
2182	6398	1066.3	164.31	27.4	Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.	Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O Lötvall	Nat Cell Biol	2007	17486113	Yes
2183	2132	1066.0	70.95	35.5	CLUSTAL: a package for performing multiple sequence alignment on a microcomputer.	D G Higgins, P M Sharp	Gene	1988	3243435	Yes
2184	1066	1066.0	0.0	0.0	The theory and applications of the exchange of inert gas at the lungs and tissues.	S S KETY	Pharmacol Rev	1951	14833874	Yes
2185	6394	1065.7	178.2	29.7	Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research.	Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat Robles	Bioinformatics	2005	16081474	Yes
2186	2131	1065.5	47.59	23.8	ERBB receptors and cancer: the complexity of targeted inhibitors.	Nancy E Hynes, Heidi A Lane	Nat Rev Cancer	2005	15864276	No
2187	6391	1065.2	173.22	28.9	GROMACS: fast, flexible, and free.	David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C Berendsen	J Comput Chem	2005	16211538	Yes
2188	1065	1065.0	30.43	30.4	Aspergillus fumigatus and aspergillosis.	J P Latgé	Clin Microbiol Rev	1999	10194462	No
2189	1065	1065.0	35.62	35.6	Varieties of impulsivity.	J L Evenden	Psychopharmacology (Berl)	1999	10550486	No
2190	1065	1065.0	26.9	26.9	Diarylethenes for Memories and Switches.	Masahiro Irie	Chem Rev	2000	11777416	Yes
2191	1065	1065.0	38.44	38.4	Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?	Thomas Grobner	Nephrol Dial Transplant	2006	16431890	Yes
2192	1064	1064.0	0.0	0.0	Cerebral blood flow and oxygen consumption in man.	N A LASSEN	Physiol Rev	1959	13645234	Yes
2193	1064	1064.0	30.31	30.3	Overview of general physiologic features and functions of vitamin D.	Hector F DeLuca	Am J Clin Nutr	2004	15585789	No
2194	2128	1064.0	61.05	30.5	Therapeutic potential of resveratrol: the in vivo evidence.	Joseph A Baur, David A Sinclair	Nat Rev Drug Discov	2006	16732220	No
2195	1063	1063.0	25.76	25.8	The Unified Medical Language System (UMLS): integrating biomedical terminology.	Olivier Bodenreider	Nucleic Acids Res	2004	14681409	Yes
2196	1063	1063.0	33.16	33.2	Stress and depression.	Constance Hammen	Annu Rev Clin Psychol	2005	17716090	No
2197	2125	1062.5	57.16	28.6	Microenvironmental regulation of metastasis.	Johanna A Joyce, Jeffrey W Pollard	Nat Rev Cancer	2009	19279573	No
2198	1062	1062.0	37.74	37.7	Isolation and cultivation of Lyme disease spirochetes.	A G Barbour	Yale J Biol Med	1984	6393604	Yes
2199	3186	1062.0	86.45	28.8	Wnt/beta-catenin signaling: components, mechanisms, and diseases.	Bryan T MacDonald, Keiko Tamai, Xi He	Dev Cell	2009	19619488	No
2200	1061	1061.0	0.0	0.0	Calcium release from the sarcoplasmic reticulum.	M Endo	Physiol Rev	1977	13441	Yes
2201	1061	1061.0	54.89	54.9	Cyclosporine.	B D Kahan	N Engl J Med	1989	2687689	No
2202	1061	1061.0	88.01	88.0	The three column spine and its significance in the classification of acute thoracolumbar spinal injuries.	F Denis	Spine (Phila Pa 1976)	1983	6670016	Yes
2203	4244	1061.0	109.45	27.4	Base-calling of automated sequencer traces using phred. I. Accuracy assessment.	B Ewing, L Hillier, M C Wendl, P Green	Genome Res	1998	9521921	Yes
2204	2122	1061.0	67.35	33.7	Antibiotic resistance of bacteria in biofilms.	P S Stewart, J W Costerton	Lancet	2001	11463434	No
2205	1061	1061.0	0.0	0.0	The measurement of volume changes in human limbs.	R J WHITNEY	J Physiol	1953	13085295	Yes
2206	1061	1061.0	34.08	34.1	Polycystic ovary syndrome.	David A Ehrmann	N Engl J Med	2005	15788499	No
2207	2121	1060.5	56.06	28.0	Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene.	M E Greenberg, E B Ziff	Nature	1984	6090941	Yes
2208	1060	1060.0	36.92	36.9	Interleukin-1 in the pathogenesis and treatment of inflammatory diseases.	Charles A Dinarello	Blood	2011	21304099	No
2209	2118	1059.0	0.0	0.0	Regulatory sequences involved in the promotion and termination of RNA transcription.	M Rosenberg, D Court	Annu Rev Genet	1979	94251	No
2210	1059	1059.0	49.97	50.0	Social phobia.	M R Liebowitz	Mod Probl Pharmacopsychiatry	1987	2885745	Yes
2211	1059	1059.0	0.0	0.0	Carbonic anhydrase: chemistry, physiology, and inhibition.	T H Maren	Physiol Rev	1967	4964060	No
2212	1059	1059.0	31.71	31.7	Psychological and neural mechanisms of the affective dimension of pain.	D D Price	Science	2000	10846154	No
2213	1059	1059.0	0.0	0.0	A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces.	M G BUONOCORE	J Dent Res	1955	13271655	Yes
2214	1059	1059.0	0.0	0.0	Modality and topographic properties of single neurons of cat's somatic sensory cortex.	V B MOUNTCASTLE	J Neurophysiol	1957	13439410	Yes
2215	1059	1059.0	27.44	27.4	Oxidative stress in neurodegeneration: cause or consequence?	Julie K Andersen	Nat Med	2004	15298006	No
2216	1059	1059.0	24.36	24.4	Solving structures of protein complexes by molecular replacement with Phaser.	Airlie J McCoy	Acta Crystallogr D Biol Crystallogr	2007	17164524	Yes
2217	2117	1058.5	0.0	0.0	Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats.	J Altman, G D Das	J Comp Neurol	1965	5861717	Yes
2218	2117	1058.5	60.9	30.4	Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments.	Gerard Talavera, Jose Castresana	Syst Biol	2007	17654362	Yes
2219	7409	1058.4	157.57	22.5	Exploration, normalization, and summaries of high density oligonucleotide array probe level data.	Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P Speed	Biostatistics	2003	12925520	Yes
2220	1058	1058.0	49.47	49.5	Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts).	G G Glenner	N Engl J Med	1980	6154243	No
2221	2116	1058.0	54.6	27.3	Disruption of epithelial cell-matrix interactions induces apoptosis.	S M Frisch, H Francis	J Cell Biol	1994	8106557	Yes
2222	1058	1058.0	24.87	24.9	Recognition and processing of ubiquitin-protein conjugates by the proteasome.	Daniel Finley	Annu Rev Biochem	2009	19489727	No
2223	3173	1057.7	184.66	61.6	Risk factors for falls among elderly persons living in the community.	M E Tinetti, M Speechley, S F Ginter	N Engl J Med	1988	3205267	Yes
2224	1057	1057.0	31.13	31.1	Rapid evolution of a protein in vitro by DNA shuffling.	W P Stemmer	Nature	1994	8047147	Yes
2225	1057	1057.0	0.0	0.0	CRYSTALLINE SOYBEAN TRYPSIN INHIBITOR : II. GENERAL PROPERTIES.	M Kunitz	J Gen Physiol	1947	19873496	Yes
2226	1056	1056.0	0.0	0.0	Computerized transverse axial scanning (tomography). 1. Description of system.	G N Hounsfield	Br J Radiol	1973	4757352	Yes
2227	1056	1056.0	26.04	26.0	The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes.	S E Kahn	Diabetologia	2003	12637977	No
2228	1056	1056.0	24.42	24.4	Neuroligins and neurexins link synaptic function to cognitive disease.	Thomas C Südhof	Nature	2008	18923512	No
2229	1056	1056.0	0.0	0.0	Note on the sampling error of the difference between correlated proportions or percentages.	Q McNEMAR	Psychometrika	1947	20254758	Yes
2230	2111	1055.5	0.0	0.0	Post-embryonic cell lineages of the nematode, Caenorhabditis elegans.	J E Sulston, H R Horvitz	Dev Biol	1977	838129	Yes
2231	1055	1055.0	34.32	34.3	Cell and environment interactions in tumor microregions: the multicell spheroid model.	R M Sutherland	Science	1988	2451290	Yes
2232	1055	1055.0	0.0	0.0	The origin of the genetic code.	F H Crick	J Mol Biol	1968	4887876	Yes
2233	1055	1055.0	68.89	68.9	Subjective well-being.	E Diener	Psychol Bull	1984	6399758	No
2234	2110	1055.0	73.67	36.8	Quality control and preprocessing of metagenomic datasets.	Robert Schmieder, Robert Edwards	Bioinformatics	2011	21278185	Yes
2235	2109	1054.5	39.5	19.8	The DNA damage response: putting checkpoints in perspective.	B B Zhou, S J Elledge	Nature	2000	11100718	No
2236	1053	1053.0	31.97	32.0	Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles.	M Kozak	Microbiol Rev	1983	6343825	No
2237	1053	1053.0	27.2	27.2	Liver fibrosis -- from bench to bedside.	Scott L Friedman	J Hepatol	2003	12591185	No
2238	1052	1052.0	47.65	47.6	UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure.	D W Russell	J Pers Assess	1996	8576833	Yes
2239	1052	1052.0	29.43	29.4	Primate anterior cingulate cortex: where motor control, drive and cognition interface.	T Paus	Nat Rev Neurosci	2001	11389475	No
2240	1051	1051.0	64.87	64.9	Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters.	P de Leva	J Biomech	1996	8872282	Yes
2241	1051	1051.0	18.06	18.1	Themes and variations on ubiquitylation.	A M Weissman	Nat Rev Mol Cell Biol	2001	11265246	No
2242	1051	1051.0	30.3	30.3	The hydrogen bond in the solid state.	Thomas Steiner	Angew Chem Int Ed Engl	2002	12491444	Yes
2243	3152	1050.7	106.54	35.5	Dose translation from animal to human studies revisited.	Shannon Reagan-Shaw, Minakshi Nihal, Nihal Ahmad	FASEB J	2008	17942826	Yes
2244	5253	1050.6	101.84	20.4	Crystal structure of the nucleosome core particle at 2.8 A resolution.	K Luger, A W Mäder, R K Richmond, D F Sargent, T J Richmond	Nature	1997	9305837	Yes
2245	3151	1050.3	0.0	0.0	The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes.	J T DODGE, C MITCHELL, D J HANAHAN	Arch Biochem Biophys	1963	14028302	Yes
2246	1050	1050.0	25.82	25.8	Molecular physiology of low-voltage-activated t-type calcium channels.	Edward Perez-Reyes	Physiol Rev	2003	12506128	No
2247	2099	1049.5	62.09	31.0	Neural systems of reinforcement for drug addiction: from actions to habits to compulsion.	Barry J Everitt, Trevor W Robbins	Nat Neurosci	2005	16251991	No
2248	1049	1049.0	0.0	0.0	Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology.	W D Hamilton	Science	1967	6021675	Yes
2249	1048	1048.0	0.0	0.0	The ultrastructural basis of capillary permeability studied with peroxidase as a tracer.	M J Karnovsky	J Cell Biol	1967	6061717	Yes
2250	1048	1048.0	33.39	33.4	Cellular oncogenes and retroviruses.	J M Bishop	Annu Rev Biochem	1983	6351725	No
2251	1048	1048.0	24.33	24.3	Caspase structure, proteolytic substrates, and function during apoptotic cell death.	D W Nicholson	Cell Death Differ	1999	10578171	No
2252	1048	1048.0	0.0	0.0	Fluorescent antibody methods.	A H COONS	Gen Cytochem Methods	1958	13574437	Yes
2253	1048	1048.0	23.9	23.9	Gene finding in novel genomes.	Ian Korf	BMC Bioinformatics	2004	15144565	Yes
2254	2096	1048.0	60.51	30.3	Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients.	S Schulman, C Kearon	J Thromb Haemost	2005	15842354	Yes
2255	3144	1048.0	100.01	33.3	Nitric oxide and peroxynitrite in health and disease.	Pál Pacher, Joseph S Beckman, Lucas Liaudet	Physiol Rev	2007	17237348	No
2256	1048	1048.0	0.0	0.0	A new specific color reaction of hexuronic acids.	Z DISCHE	J Biol Chem	1947	20281638	Yes
2257	2094	1047.0	46.05	23.0	Molecular chaperones in the cytosol: from nascent chain to folded protein.	F Ulrich Hartl, Manajit Hayer-Hartl	Science	2002	11884745	No
2258	1047	1047.0	22.65	22.6	Mechanisms of caspase activation and inhibition during apoptosis.	Yigong Shi	Mol Cell	2002	11931755	No
2259	1047	1047.0	26.57	26.6	Production of recombinant protein therapeutics in cultivated mammalian cells.	Florian M Wurm	Nat Biotechnol	2004	15529164	No
2260	1047	1047.0	30.2	30.2	Plasmonics: merging photonics and electronics at nanoscale dimensions.	Ekmel Ozbay	Science	2006	16410515	Yes
2261	1047	1047.0	54.39	54.4	Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement.	Virginia A Moyer	Ann Intern Med	2014	24378917	No
2262	2093	1046.5	0.0	0.0	A general method for isolation of high molecular weight DNA from eukaryotes.	N Blin, D W Stafford	Nucleic Acids Res	1976	987581	Yes
2263	2093	1046.5	63.49	31.7	Meeting of minds: the medial frontal cortex and social cognition.	David M Amodio, Chris D Frith	Nat Rev Neurosci	2006	16552413	No
2264	4184	1046.0	98.3	24.6	Interleukin-10 and the interleukin-10 receptor.	K W Moore, R de Waal Malefyt, R L Coffman, A O'Garra	Annu Rev Immunol	2001	11244051	No
2265	1046	1046.0	22.4	22.4	Lipid rafts: elusive or illusive?	Sean Munro	Cell	2003	14622593	No
2266	1046	1046.0	33.75	33.8	Plant productivity and environment.	J S Boyer	Science	1982	17808529	Yes
2267	2091	1045.5	63.23	31.6	Alternative activation of macrophages: mechanism and functions.	Siamon Gordon, Fernando O Martinez	Immunity	2010	20510870	No
2268	1045	1045.0	26.43	26.4	Double identity for proteins of the Bcl-2 family.	J C Reed	Nature	1997	9194558	No
2269	1045	1045.0	30.83	30.8	Q-ball imaging.	David S Tuch	Magn Reson Med	2004	15562495	Yes
2270	1045	1045.0	22.04	22.0	IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors.	Yong-Jun Liu	Annu Rev Immunol	2005	15771572	No
2271	1045	1045.0	36.27	36.3	Endometriosis.	Serdar E Bulun	N Engl J Med	2009	19144942	No
2272	3135	1045.0	123.41	41.1	Rehospitalizations among patients in the Medicare fee-for-service program.	Stephen F Jencks, Mark V Williams, Eric A Coleman	N Engl J Med	2009	19339721	Yes
2273	9399	1044.3	373.01	41.4	The 1982 revised criteria for the classification of systemic lupus erythematosus.	E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J Winchester	Arthritis Rheum	1982	7138600	Yes
2274	1044	1044.0	32.39	32.4	Internal models for motor control and trajectory planning.	M Kawato	Curr Opin Neurobiol	1999	10607637	No
2275	4176	1044.0	119.34	29.8	Microbial ecology: human gut microbes associated with obesity.	Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I Gordon	Nature	2006	17183309	Yes
2276	3131	1043.7	125.41	41.8	Factor structure of the Barratt impulsiveness scale.	J H Patton, M S Stanford, E S Barratt	J Clin Psychol	1995	8778124	Yes
2277	1043	1043.0	33.44	33.4	Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena.	U Mitzdorf	Physiol Rev	1985	3880898	No
2278	1043	1043.0	31.99	32.0	The aryl hydrocarbon receptor complex.	O Hankinson	Annu Rev Pharmacol Toxicol	1995	7598497	No
2279	1043	1043.0	28.97	29.0	Papillomavirus infections--a major cause of human cancers.	H zur Hausen	Biochim Biophys Acta	1996	8876633	No
2280	1043	1043.0	52.35	52.4	Selenium and human health.	Margaret P Rayman	Lancet	2012	22381456	No
2281	1042	1042.0	39.68	39.7	An application of prefrontal cortex function theory to cognitive aging.	R L West	Psychol Bull	1996	8831298	No
2282	1042	1042.0	25.86	25.9	S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles.	R Donato	Int J Biochem Cell Biol	2001	11390274	No
2283	1042	1042.0	25.81	25.8	Nuclear factor-kappaB: the enemy within.	Bharat B Aggarwal	Cancer Cell	2004	15380510	No
2284	2083	1041.5	58.78	29.4	Myocardial reperfusion injury.	Derek M Yellon, Derek J Hausenloy	N Engl J Med	2007	17855673	No
2285	1041	1041.0	51.01	51.0	Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.	A H Conney	Cancer Res	1982	6814745	No
2286	2082	1041.0	59.06	29.5	The free radical theory of aging matures.	K B Beckman, B N Ames	Physiol Rev	1998	9562038	No
2287	1041	1041.0	0.0	0.0	On the law of effect.	R J Herrnstein	J Exp Anal Behav	1970	16811440	Yes
2288	1040	1040.0	0.0	0.0	Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate.	J W Olney	Science	1969	5778021	Yes
2289	2080	1040.0	74.73	37.4	Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins.	D Marion, K Wüthrich	Biochem Biophys Res Commun	1983	6307308	Yes
2290	1040	1040.0	31.14	31.1	Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS.	Paul Willner	Neuropsychobiology	2005	16037678	No
2291	2079	1039.5	80.75	40.4	Oxidative mechanisms in the toxicity of metal ions.	S J Stohs, D Bagchi	Free Radic Biol Med	1995	7744317	No
2292	1039	1039.0	35.33	35.3	Rheumatoid arthritis. Pathophysiology and implications for therapy.	E D Harris	N Engl J Med	1990	2271017	No
2293	1039	1039.0	39.47	39.5	Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.	A E Pegg	Cancer Res	1988	3123052	No
2294	3117	1039.0	0.0	0.0	A highly sensitive adenylate cyclase assay.	Y Salomon, C Londos, M Rodbell	Anal Biochem	1974	4827395	Yes
2295	1039	1039.0	0.0	0.0	Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.	K S McCully	Am J Pathol	1969	5792556	Yes
2296	1039	1039.0	42.57	42.6	Glycosphingolipids in cellular interaction, differentiation, and oncogenesis.	S Hakomori	Annu Rev Biochem	1981	7023369	No
2297	1039	1039.0	43.4	43.4	Inhibition and facilitation of nucleic acid amplification.	I G Wilson	Appl Environ Microbiol	1997	9327537	No
2298	1039	1039.0	20.4	20.4	Kinesin and dynein superfamily proteins and the mechanism of organelle transport.	N Hirokawa	Science	1998	9438838	No
2299	1039	1039.0	26.6	26.6	Physiological and molecular basis of thyroid hormone action.	P M Yen	Physiol Rev	2001	11427693	No
2300	1039	1039.0	19.17	19.2	Cancer susceptibility and the functions of BRCA1 and BRCA2.	Ashok R Venkitaraman	Cell	2002	11832208	No
2301	1039	1039.0	23.6	23.6	The roles of intracellular protein-degradation pathways in neurodegeneration.	David C Rubinsztein	Nature	2006	17051204	No
2302	2077	1038.5	84.66	42.3	The framing of decisions and the psychology of choice.	A Tversky, D Kahneman	Science	1981	7455683	Yes
2303	5191	1038.2	243.04	48.6	Evidence based medicine: what it is and what it isn't.	D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S Richardson	BMJ	1996	8555924	No
2304	1038	1038.0	38.09	38.1	The Neuropsychiatric Inventory: assessing psychopathology in dementia patients.	J L Cummings	Neurology	1997	9153155	No
2305	1038	1038.0	43.84	43.8	Multimodal approach to control postoperative pathophysiology and rehabilitation.	H Kehlet	Br J Anaesth	1997	9175983	No
2306	2075	1037.5	60.78	30.4	Rising incidence of hepatocellular carcinoma in the United States.	H B El-Serag, A C Mason	N Engl J Med	1999	10072408	Yes
2307	3112	1037.3	65.02	21.7	The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.	Fabio Martinon, Kimberly Burns, Jürg Tschopp	Mol Cell	2002	12191486	Yes
2308	1037	1037.0	32.28	32.3	Neural simulation of action: a unifying mechanism for motor cognition.	M Jeannerod	Neuroimage	2001	11373140	No
2309	1037	1037.0	20.9	20.9	A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development.	Xuemei Chen	Science	2004	12893888	Yes
2310	6221	1036.8	126.7	21.1	Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.	S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T Tuschl	Nature	2001	11373684	Yes
2311	1036	1036.0	21.51	21.5	Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast.	R Rothstein	Methods Enzymol	1991	2005793	Yes
2312	2072	1036.0	56.61	28.3	Integrins and signal transduction pathways: the road taken.	E A Clark, J S Brugge	Science	1995	7716514	No
2313	2072	1036.0	0.0	0.0	Mutants of Escherichia coli requiring methionine or vitamin B12.	B D DAVIS, E S MINGIOLI	J Bacteriol	1950	15436457	Yes
2314	1036	1036.0	30.16	30.2	Hydrogen sulphide and its therapeutic potential.	Csaba Szabó	Nat Rev Drug Discov	2007	17948022	No
2315	1035	1035.0	38.09	38.1	Classification of chronic viral hepatitis: a need for reassessment.	P J Scheuer	J Hepatol	1991	1808228	No
2316	2070	1035.0	66.75	33.4	Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.	C Auffray, F Rougeon	Eur J Biochem	1980	6772444	Yes
2317	1034	1034.0	39.31	39.3	Pathogenetic mechanisms of septic shock.	J E Parrillo	N Engl J Med	1993	8479467	No
2318	1034	1034.0	37.34	37.3	Depression in late life: review and commentary.	Dan G Blazer	J Gerontol A Biol Sci Med Sci	2003	12634292	No
2319	2067	1033.5	40.96	20.5	The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.	T Maehama, J E Dixon	J Biol Chem	1998	9593664	Yes
2320	1033	1033.0	54.25	54.2	The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence.	E J Khantzian	Am J Psychiatry	1985	3904487	No
2321	1033	1033.0	0.0	0.0	Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report.	C S Neer	J Bone Joint Surg Am	1972	5054450	Yes
2322	3097	1032.3	83.56	27.9	Global and societal implications of the diabetes epidemic.	P Zimmet, K G Alberti, J Shaw	Nature	2001	11742409	No
2323	2064	1032.0	73.98	37.0	Plasmonics for improved photovoltaic devices.	Harry A Atwater, Albert Polman	Nat Mater	2010	20168344	Yes
2324	16497	1031.1	644.59	40.3	Fiji: an open-source platform for biological-image analysis.	Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert Cardona	Nat Methods	2012	22743772	Yes
2325	1031	1031.0	0.0	0.0	Atherogenesis: a postprandial phenomenon.	D B Zilversmit	Circulation	1979	222498	Yes
2326	2062	1031.0	53.57	26.8	Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis.	M Fried, D M Crothers	Nucleic Acids Res	1981	6275366	Yes
2327	3092	1030.7	136.04	45.3	Structure-antioxidant activity relationships of flavonoids and phenolic acids.	C A Rice-Evans, N J Miller, G Paganga	Free Radic Biol Med	1996	8743980	Yes
2328	2061	1030.5	66.41	33.2	A review of central 5-HT receptors and their function.	N M Barnes, T Sharp	Neuropharmacology	1999	10462127	No
2329	1030	1030.0	36.14	36.1	A Wilcoxon-type test for trend.	J Cuzick	Stat Med	1985	3992076	Yes
2330	1029	1029.0	31.33	31.3	VLA proteins in the integrin family: structures, functions, and their role on leukocytes.	M E Hemler	Annu Rev Immunol	1990	2188667	No
2331	2058	1029.0	48.25	24.1	CpG islands in vertebrate genomes.	M Gardiner-Garden, M Frommer	J Mol Biol	1987	3656447	Yes
2332	1029	1029.0	0.0	0.0	The organization of proteins in the human red blood cell membrane. A review.	T L Steck	J Cell Biol	1974	4600883	No
2333	1029	1029.0	29.38	29.4	Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics.	G L Semenza	Oncogene	2010	19946328	No
2334	1028	1028.0	33.9	33.9	Type I diabetes mellitus. A chronic autoimmune disease.	G S Eisenbarth	N Engl J Med	1986	3517648	No
2335	2055	1027.5	63.96	32.0	The cognitive control of emotion.	Kevin N Ochsner, James J Gross	Trends Cogn Sci	2005	15866151	No
2336	1027	1027.0	30.18	30.2	Surrogate endpoints in clinical trials: definition and operational criteria.	R L Prentice	Stat Med	1989	2727467	Yes
2337	1027	1027.0	36.57	36.6	The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases.	Artemis P Simopoulos	Exp Biol Med (Maywood)	2008	18408140	No
2338	2053	1026.5	133.42	66.7	Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique.	S F Dworkin, L LeResche	J Craniomandib Disord	1992	1298767	No
2339	2053	1026.5	0.0	0.0	Prediction of protein conformation.	P Y Chou, G D Fasman	Biochemistry	1974	4358940	Yes
2340	1026	1026.0	0.0	0.0	Superoxide dismutases.	I Fridovich	Annu Rev Biochem	1975	1094908	No
2341	1026	1026.0	0.0	0.0	An enzymic method for the trace iodination of immunoglobulins and other proteins.	J J Marchalonis	Biochem J	1969	4185494	Yes
2342	2051	1025.5	48.43	24.2	Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms.	Eugenia E Calle, Rudolf Kaaks	Nat Rev Cancer	2004	15286738	No
2343	1025	1025.0	0.0	0.0	The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept.	A G Pearse	J Histochem Cytochem	1969	4143745	No
2344	2050	1025.0	0.0	0.0	Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration.	D B Dill, D L Costill	J Appl Physiol	1974	4850854	Yes
2345	2049	1024.5	0.0	0.0	Assay of proteins in the presence of interfering materials.	A Bensadoun, D Weinstein	Anal Biochem	1976	1259145	Yes
2346	2049	1024.5	66.16	33.1	Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule.	M D Pierschbacher, E Ruoslahti	Nature	1984	6325925	Yes
2347	1024	1024.0	0.0	0.0	Defective repair replication of DNA in xeroderma pigmentosum.	J E Cleaver	Nature	1968	5655953	Yes
2348	1024	1024.0	28.89	28.9	The neuropathology of schizophrenia. A critical review of the data and their interpretation.	P J Harrison	Brain	1999	10219775	No
2349	2047	1023.5	49.99	25.0	Can the pharmaceutical industry reduce attrition rates?	Ismail Kola, John Landis	Nat Rev Drug Discov	2004	15286737	No
2350	1023	1023.0	0.0	0.0	Metabolic stability and epigenesis in randomly constructed genetic nets.	S A Kauffman	J Theor Biol	1969	5803332	Yes
2351	1023	1023.0	48.78	48.8	Translating social ecological theory into guidelines for community health promotion.	D Stokols	Am J Health Promot	1996	10159709	No
2352	1023	1023.0	26.6	26.6	Huntington's disease.	Francis O Walker	Lancet	2007	17240289	No
2353	2044	1022.0	79.9	40.0	The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.	W R Gibb, A J Lees	J Neurol Neurosurg Psychiatry	1988	2841426	No
2354	1022	1022.0	25.14	25.1	Neurobiology of Pavlovian fear conditioning.	S Maren	Annu Rev Neurosci	2001	11520922	No
2355	1022	1022.0	24.75	24.8	Microglia as a source and target of cytokines.	Uwe-Karsten Hanisch	Glia	2002	12379902	No
2356	1022	1022.0	31.33	31.3	How brains beware: neural mechanisms of emotional attention.	Patrik Vuilleumier	Trends Cogn Sci	2005	16289871	Yes
2357	1022	1022.0	24.54	24.5	Human natural killer cells.	Michael A Caligiuri	Blood	2008	18650461	No
2358	2043	1021.5	88.36	44.2	Neutrophil recruitment and function in health and inflammation.	Elzbieta Kolaczkowska, Paul Kubes	Nat Rev Immunol	2013	23435331	No
2359	1021	1021.0	0.0	0.0	Optimal foraging, the marginal value theorem.	E L Charnov	Theor Popul Biol	1976	1273796	Yes
2360	2042	1021.0	62.9	31.4	Imaging cognition II: An empirical review of 275 PET and fMRI studies.	R Cabeza, L Nyberg	J Cogn Neurosci	2000	10769304	No
2361	1021	1021.0	32.82	32.8	Emotion regulation: affective, cognitive, and social consequences.	James J Gross	Psychophysiology	2002	12212647	No
2362	1021	1021.0	34.4	34.4	Cytokinesis-block micronucleus cytome assay.	Michael Fenech	Nat Protoc	2007	17546000	Yes
2363	1020	1020.0	33.57	33.6	The induction of pain: an integrative review.	M J Millan	Prog Neurobiol	1999	9987804	No
2364	2040	1020.0	64.48	32.2	Increasing incidence of thyroid cancer in the United States, 1973-2002.	Louise Davies, H Gilbert Welch	JAMA	2006	16684987	Yes
2365	2040	1020.0	68.82	34.4	The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin.	W L Jorgensen, J Tirado-Rives	J Am Chem Soc	1988	27557051	Yes
2366	2039	1019.5	101.18	50.6	Reading senseless sentences: brain potentials reflect semantic incongruity.	M Kutas, S A Hillyard	Science	1980	7350657	Yes
2367	1019	1019.0	0.0	0.0	The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C.	R G Khalifah	J Biol Chem	1971	4994926	Yes
2368	1019	1019.0	27.61	27.6	Matrix proteoglycans: from molecular design to cellular function.	R V Iozzo	Annu Rev Biochem	1998	9759499	No
2369	1019	1019.0	26.38	26.4	Mitochondrial transport of cations: channels, exchangers, and permeability transition.	P Bernardi	Physiol Rev	1999	10508231	No
2370	1019	1019.0	23.24	23.2	Assortative mixing in networks.	M E J Newman	Phys Rev Lett	2002	12443515	Yes
2371	4076	1019.0	168.71	42.2	Prevalence and trends in obesity among US adults, 1999-2008.	Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R Curtin	JAMA	2010	20071471	Yes
2372	2037	1018.5	50.2	25.1	Adaptive protein evolution at the Adh locus in Drosophila.	J H McDonald, M Kreitman	Nature	1991	1904993	Yes
2373	2037	1018.5	97.77	48.9	Malondialdehyde determination as index of lipid peroxidation.	H H Draper, M Hadley	Methods Enzymol	1990	2233309	Yes
2374	1018	1018.0	68.42	68.4	The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation.	G A Ilizarov	Clin Orthop Relat Res	1989	2910611	Yes
2375	1018	1018.0	34.92	34.9	Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.	Felix Kratz	J Control Release	2008	18582981	No
2376	3053	1017.7	112.0	37.3	Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria.	S van der Linden, H A Valkenburg, A Cats	Arthritis Rheum	1984	6231933	Yes
2377	2035	1017.5	54.39	27.2	The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications.	P M Sharp, W H Li	Nucleic Acids Res	1987	3547335	Yes
2378	2035	1017.5	45.86	22.9	The mammalian unfolded protein response.	Martin Schröder, Randal J Kaufman	Annu Rev Biochem	2005	15952902	No
2379	2035	1017.5	95.99	48.0	The M1 and M2 paradigm of macrophage activation: time for reassessment.	Fernando O Martinez, Siamon Gordon	F1000Prime Rep	2014	24669294	No
2380	3052	1017.3	0.0	0.0	Improved method for the determination of blood glutathione.	E BEUTLER, O DURON, B M KELLY	J Lab Clin Med	1963	13967893	Yes
2381	1017	1017.0	42.97	43.0	Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds.	A J Alpert	J Chromatogr	1990	2324207	Yes
2382	1017	1017.0	35.48	35.5	Invasive aspergillosis.	D W Denning	Clin Infect Dis	1998	9564455	No
2383	1017	1017.0	0.0	0.0	The estimation of phosphorus.	R J Allen	Biochem J	1940	16747230	Yes
2384	1017	1017.0	29.3	29.3	Mitochondrial fusion and fission in cell life and death.	Benedikt Westermann	Nat Rev Mol Cell Biol	2010	21102612	No
2385	3050	1016.7	69.83	23.3	Toll-like receptors: critical proteins linking innate and acquired immunity.	S Akira, K Takeda, T Kaisho	Nat Immunol	2001	11477402	No
2386	1016	1016.0	22.9	22.9	Morphogenetic roles of classic cadherins.	M Takeichi	Curr Opin Cell Biol	1995	8573335	No
2387	1016	1016.0	26.07	26.1	The path to ubiquitous and low-cost organic electronic appliances on plastic.	Stephen R Forrest	Nature	2004	15118718	Yes
2388	4064	1016.0	105.41	26.4	Autophagy fights disease through cellular self-digestion.	Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky	Nature	2008	18305538	No
2389	1016	1016.0	102.7	102.7	Minimap2: pairwise alignment for nucleotide sequences.	Heng Li	Bioinformatics	2018	29750242	Yes
2390	3047	1015.7	68.41	22.8	Cellular survival: a play in three Akts.	S R Datta, A Brunet, M E Greenberg	Genes Dev	1999	10579998	No
2391	11167	1015.2	425.99	38.7	A new equation to estimate glomerular filtration rate.	Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef Coresh	Ann Intern Med	2009	19414839	Yes
2392	1015	1015.0	23.33	23.3	STATs: signal transducers and activators of transcription.	J N Ihle	Cell	1996	8608586	No
2393	3045	1015.0	99.65	33.2	Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles.	Günter Oberdörster, Eva Oberdörster, Jan Oberdörster	Environ Health Perspect	2005	16002369	No
2394	1015	1015.0	27.4	27.4	Non-Smad pathways in TGF-beta signaling.	Ying E Zhang	Cell Res	2009	19114990	No
2395	2029	1014.5	157.03	78.5	A joint coordinate system for the clinical description of three-dimensional motions: application to the knee.	E S Grood, W J Suntay	J Biomech Eng	1983	6865355	Yes
2396	3042	1014.0	0.0	0.0	Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins.	J Garnier, D J Osguthorpe, B Robson	J Mol Biol	1978	642007	Yes
2397	2028	1014.0	59.29	29.6	Nanostructures in biodiagnostics.	Nathaniel L Rosi, Chad A Mirkin	Chem Rev	2005	15826019	No
2398	1014	1014.0	23.79	23.8	Version 1.2 of the Crystallography and NMR system.	Axel T Brunger	Nat Protoc	2007	18007608	Yes
2399	2026	1013.0	48.18	24.1	Functions of lipid rafts in biological membranes.	D A Brown, E London	Annu Rev Cell Dev Biol	1998	9891780	No
2400	2025	1012.5	53.69	26.8	Peroxisome proliferator-activated receptors: nuclear control of metabolism.	B Desvergne, W Wahli	Endocr Rev	1999	10529898	No
2401	2025	1012.5	47.19	23.6	Toll-like receptors in the induction of the innate immune response.	A Aderem, R J Ulevitch	Nature	2000	10963608	No
2402	1012	1012.0	26.02	26.0	The prefrontal cortex and cognitive control.	E K Miller	Nat Rev Neurosci	2000	11252769	No
2403	1012	1012.0	30.57	30.6	Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence.	Earl S Ford	Diabetes Care	2005	15983333	No
2404	2023	1011.5	129.83	64.9	A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain.	M Roland, R Morris	Spine (Phila Pa 1976)	1983	6222486	Yes
2405	2023	1011.5	72.37	36.2	An estimate of the worldwide prevalence and disability associated with osteoporotic fractures.	O Johnell, J A Kanis	Osteoporos Int	2006	16983459	Yes
2406	2022	1011.0	0.0	0.0	Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents.	L F Berkman, S L Syme	Am J Epidemiol	1979	425958	Yes
2407	3033	1011.0	105.56	35.2	The functional anatomy of basal ganglia disorders.	R L Albin, A B Young, J B Penney	Trends Neurosci	1989	2479133	No
2408	4043	1010.8	140.59	35.1	clusterProfiler: an R package for comparing biological themes among gene clusters.	Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu He	OMICS	2012	22455463	Yes
2409	3032	1010.7	86.14	28.7	LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions.	A C Wallace, R A Laskowski, J M Thornton	Protein Eng	1995	7630882	Yes
2410	2021	1010.5	38.02	19.0	Stats: transcriptional control and biological impact.	David E Levy, J E Darnell	Nat Rev Mol Cell Biol	2002	12209125	No
2411	2021	1010.5	45.49	22.7	Tumorigenesis and the angiogenic switch.	Gabriele Bergers, Laura E Benjamin	Nat Rev Cancer	2003	12778130	No
2412	1010	1010.0	31.6	31.6	Normalization of cell responses in cat striate cortex.	D J Heeger	Vis Neurosci	1992	1504027	Yes
2413	1010	1010.0	29.51	29.5	Neural systems for recognizing emotion.	Ralph Adolphs	Curr Opin Neurobiol	2002	12015233	No
2414	1010	1010.0	30.44	30.4	Physiology and pathophysiology of purinergic neurotransmission.	Geoffrey Burnstock	Physiol Rev	2007	17429044	No
2415	1010	1010.0	25.4	25.4	The impact of next-generation sequencing technology on genetics.	Elaine R Mardis	Trends Genet	2008	18262675	No
2416	1009	1009.0	45.84	45.8	The life and times of the Enterococcus.	B E Murray	Clin Microbiol Rev	1990	2404568	No
2417	2018	1009.0	61.98	31.0	Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.	Ajay Kumar Gupta, Mona Gupta	Biomaterials	2005	15626447	No
2418	1009	1009.0	31.68	31.7	Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective.	Antoine Bechara	Nat Neurosci	2005	16251988	No
2419	2015	1007.5	38.41	19.2	Hedgehog signaling in animal development: paradigms and principles.	P W Ingham, A P McMahon	Genes Dev	2001	11731473	No
2420	2015	1007.5	49.43	24.7	Toll-like receptors in innate immunity.	Kiyoshi Takeda, Shizuo Akira	Int Immunol	2005	15585605	No
2421	1007	1007.0	33.25	33.2	The molecular genetics of cancer.	J M Bishop	Science	1987	3541204	No
2422	1007	1007.0	41.47	41.5	Density matrix formulation for quantum renormalization groups.	White	Phys Rev Lett	1992	10046608	Yes
2423	2014	1007.0	55.91	28.0	Drug delivery systems: entering the mainstream.	Theresa M Allen, Pieter R Cullis	Science	2004	15031496	Yes
2424	1007	1007.0	35.06	35.1	Mitochondria and cancer.	Douglas C Wallace	Nat Rev Cancer	2012	23001348	No
2425	2013	1006.5	61.27	30.6	A neurotrophic model for stress-related mood disorders.	Ronald S Duman, Lisa M Monteggia	Biol Psychiatry	2006	16631126	No
2426	1006	1006.0	0.0	0.0	Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein.	T Spector	Anal Biochem	1978	655375	Yes
2427	1006	1006.0	82.32	82.3	Impingement lesions.	C S Neer	Clin Orthop Relat Res	1983	6825348	Yes
2428	2011	1005.5	47.79	23.9	T-cell antigen receptor genes and T-cell recognition.	M M Davis, P J Bjorkman	Nature	1988	3043226	No
2429	1005	1005.0	23.67	23.7	Physiological concentrations of purines and pyrimidines.	T W Traut	Mol Cell Biochem	1994	7877593	No
2430	2009	1004.5	42.33	21.2	NF-kappaB at the crossroads of life and death.	Michael Karin, Anning Lin	Nat Immunol	2002	11875461	No
2431	3013	1004.3	132.33	44.1	Vascular endothelial cells synthesize nitric oxide from L-arginine.	R M Palmer, D S Ashton, S Moncada	Nature	1988	3131684	Yes
2432	1004	1004.0	86.53	86.5	The problem of rigor in qualitative research.	M Sandelowski	ANS Adv Nurs Sci	1986	3083765	Yes
2433	1004	1004.0	18.62	18.6	Stem cells: units of development, units of regeneration, and units in evolution.	I L Weissman	Cell	2000	10647940	No
2434	1004	1004.0	39.79	39.8	Risk and maintenance factors for eating pathology: a meta-analytic review.	Eric Stice	Psychol Bull	2002	12206196	No
2435	1004	1004.0	0.0	0.0	LINKED FUNCTIONS AND RECIPROCAL EFFECTS IN HEMOGLOBIN: A SECOND LOOK.	J WYMAN	Adv Protein Chem	1964	14268785	No
2436	2007	1003.5	64.06	32.0	Epidemiology and outcomes of osteoporotic fractures.	Steven R Cummings, L Joseph Melton	Lancet	2002	12049882	No
2437	7022	1003.1	357.69	51.1	Development and validation of a geriatric depression screening scale: a preliminary report.	J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O Leirer	J Psychiatr Res	1982	7183759	Yes
2438	1003	1003.0	0.0	0.0	The intraclass correlation coefficient as a measure of reliability.	J J Bartko	Psychol Rep	1966	5942109	Yes
2439	2004	1002.0	74.73	37.4	Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.	J I Morgan, T Curran	Annu Rev Neurosci	1991	1903243	No
2440	1002	1002.0	28.76	28.8	Somatostatin and its receptor family.	Y C Patel	Front Neuroendocrinol	1999	10433861	No
2441	2004	1002.0	53.38	26.7	Raster3D Version 2.0. A program for photorealistic molecular graphics.	E A Merritt, M E Murphy	Acta Crystallogr D Biol Crystallogr	1994	15299354	Yes
2442	1002	1002.0	28.73	28.7	Wound healing and its impairment in the diabetic foot.	Vincent Falanga	Lancet	2005	16291068	No
2443	2003	1001.5	45.25	22.6	NF-kappaB: linking inflammation and immunity to cancer development and progression.	Michael Karin, Florian R Greten	Nat Rev Immunol	2005	16175180	No
2444	1001	1001.0	35.64	35.6	Early signals in the mitogenic response.	E Rozengurt	Science	1986	3018928	No
2445	1001	1001.0	21.87	21.9	Cytokines induce the development of functionally heterogeneous T helper cell subsets.	A O'Garra	Immunity	1998	9529145	No
2446	1001	1001.0	26.29	26.3	Metastatic bone disease: clinical features, pathophysiology and treatment strategies.	R E Coleman	Cancer Treat Rev	2001	11417967	No
2447	1001	1001.0	24.47	24.5	Next-generation DNA sequencing methods.	Elaine R Mardis	Annu Rev Genomics Hum Genet	2008	18576944	No
2448	2002	1001.0	47.31	23.7	The canonical Notch signaling pathway: unfolding the activation mechanism.	Raphael Kopan, Maria Xenia G Ilagan	Cell	2009	19379690	No
2449	2000	1000.0	77.69	38.8	Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.	J E Hixson, D T Vernier	J Lipid Res	1990	2341813	Yes
2450	1000	1000.0	44.57	44.6	Quantitative methods in the review of epidemiologic literature.	S Greenland	Epidemiol Rev	1987	3678409	Yes
2451	1000	1000.0	46.85	46.9	Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living.	S Katz	J Am Geriatr Soc	1983	6418786	No
2452	1000	1000.0	33.49	33.5	Water as an active constituent in cell biology.	Philip Ball	Chem Rev	2008	18095715	No
2453	1000	1000.0	36.59	36.6	Breakthrough of the year 2013. Cancer immunotherapy.	Jennifer Couzin-Frankel	Science	2013	24357284	No
2454	1999	999.5	65.1	32.5	Production of single-stranded plasmid DNA.	J Vieira, J Messing	Methods Enzymol	1987	3323803	Yes
2455	1998	999.0	0.0	0.0	Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.	G Blobel, B Dobberstein	J Cell Biol	1975	811671	Yes
2456	999	999.0	34.46	34.5	Analyzing the mosaic structure of genes.	J M Smith	J Mol Evol	1992	1556748	No
2457	999	999.0	32.12	32.1	Low density lipoprotein oxidation and its pathobiological significance.	D Steinberg	J Biol Chem	1997	9261091	No
2458	998	998.0	50.68	50.7	A cochlear frequency-position function for several species--29 years later.	D D Greenwood	J Acoust Soc Am	1990	2373794	Yes
2459	998	998.0	51.7	51.7	Human agency in social cognitive theory.	A Bandura	Am Psychol	1989	2782727	Yes
2460	998	998.0	32.27	32.3	The biochemistry and medical significance of the flavonoids.	Bent H Havsteen	Pharmacol Ther	2002	12453566	No
2461	998	998.0	37.36	37.4	Socioeconomic status and obesity.	Lindsay McLaren	Epidemiol Rev	2007	17478442	No
2462	998	998.0	61.77	61.8	Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial.	Kevin A Hallgren	Tutor Quant Methods Psychol	2012	22833776	Yes
2463	2992	997.3	109.41	36.5	MR diffusion tensor spectroscopy and imaging.	P J Basser, J Mattiello, D LeBihan	Biophys J	1994	8130344	Yes
2464	1994	997.0	0.0	0.0	Glutathione peroxidase activity in selenium-deficient rat liver.	R A Lawrence, R F Burk	Biochem Biophys Res Commun	1976	971321	Yes
2465	997	997.0	30.03	30.0	The lipocalin protein family: structure and function.	D R Flower	Biochem J	1996	8761444	No
2466	997	997.0	24.64	24.6	Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis.	Tirion	Phys Rev Lett	1996	10063201	Yes
2467	1994	997.0	70.15	35.1	A cognitive model of posttraumatic stress disorder.	A Ehlers, D M Clark	Behav Res Ther	2000	10761279	No
2468	3987	996.8	113.83	28.5	Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites.	H Nielsen, J Engelbrecht, S Brunak, G von Heijne	Protein Eng	1997	9051728	Yes
2469	1992	996.0	46.65	23.3	Sequence logos: a new way to display consensus sequences.	T D Schneider, R M Stephens	Nucleic Acids Res	1990	2172928	Yes
2470	996	996.0	44.45	44.5	Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes.	M A Lemp	CLAO J	1995	8565190	No
2471	996	996.0	59.9	59.9	Derivation and validation of a short-form oral health impact profile.	G D Slade	Community Dent Oral Epidemiol	1997	9332805	Yes
2472	1992	996.0	40.8	20.4	Rho GTPases: biochemistry and biology.	Aron B Jaffe, Alan Hall	Annu Rev Cell Dev Biol	2005	16212495	No
2473	996	996.0	29.11	29.1	Polymer conjugates as anticancer nanomedicines.	Ruth Duncan	Nat Rev Cancer	2006	16900224	No
2474	1991	995.5	0.0	0.0	The effect of sodium ions on the electrical activity of giant axon of the squid.	A L HODGKIN, B KATZ	J Physiol	1949	18128147	Yes
2475	2986	995.3	89.11	29.7	Bacterial biofilms: from the natural environment to infectious diseases.	Luanne Hall-Stoodley, J William Costerton, Paul Stoodley	Nat Rev Microbiol	2004	15040259	No
2476	995	995.0	25.83	25.8	The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats.	G B Morin	Cell	1989	2805070	Yes
2477	995	995.0	17.24	17.2	Mitotic kinases as regulators of cell division and its checkpoints.	E A Nigg	Nat Rev Mol Cell Biol	2001	11413462	No
2478	995	995.0	0.0	0.0	ANTIGEN-ANTIBODY CROSSED ELECTROPHORESIS.	C B LAURELL	Anal Biochem	1965	14302464	Yes
2479	995	995.0	25.98	26.0	Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.	Hiroshi Takayanagi	Nat Rev Immunol	2007	17380158	No
2480	995	995.0	39.2	39.2	The epidemiology of adult obstructive sleep apnea.	Naresh M Punjabi	Proc Am Thorac Soc	2008	18250205	No
2481	6965	995.0	245.8	35.1	AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility.	Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J Olson	J Comput Chem	2009	19399780	Yes
2482	995	995.0	39.23	39.2	The amazing osteocyte.	Lynda F Bonewald	J Bone Miner Res	2011	21254230	No
2483	1989	994.5	62.31	31.2	Integrins in cancer: biological implications and therapeutic opportunities.	Jay S Desgrosellier, David A Cheresh	Nat Rev Cancer	2010	20029421	No
2484	3977	994.2	0.0	0.0	Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.	D W Cleveland, S G Fischer, M W Kirschner, U K Laemmli	J Biol Chem	1977	320200	Yes
2485	994	994.0	0.0	0.0	A comparison of canal preparations in straight and curved root canals.	S W Schneider	Oral Surg Oral Med Oral Pathol	1971	5284110	Yes
2486	1988	994.0	51.32	25.7	Emerging roles of caspase-3 in apoptosis.	A G Porter, R U Jänicke	Cell Death Differ	1999	10200555	No
2487	994	994.0	24.87	24.9	Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach.	Michael J Sanderson	Mol Biol Evol	2002	11752195	Yes
2488	994	994.0	22.44	22.4	Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy.	Harold F Dvorak	J Clin Oncol	2002	12409337	No
2489	2982	994.0	67.22	22.4	Adjusting batch effects in microarray expression data using empirical Bayes methods.	W Evan Johnson, Cheng Li, Ariel Rabinovic	Biostatistics	2007	16632515	Yes
2490	2981	993.7	178.69	59.6	In search of how people change. Applications to addictive behaviors.	J O Prochaska, C C DiClemente, J C Norcross	Am Psychol	1992	1329589	Yes
2491	1987	993.5	0.0	0.0	A new scale of social desirability independent of psychopathology.	D P CROWNE, D MARLOWE	J Consult Psychol	1960	13813058	Yes
2492	3974	993.5	121.68	30.4	Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond.	Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S Vasan	Stat Med	2008	17569110	Yes
2493	1987	993.5	102.38	51.2	ROS function in redox signaling and oxidative stress.	Michael Schieber, Navdeep S Chandel	Curr Biol	2014	24845678	No
2494	993	993.0	33.81	33.8	Tumor necrosis factor (TNF).	L J Old	Science	1985	2413547	Yes
2495	993	993.0	0.0	0.0	A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon.	A M Olovnikov	J Theor Biol	1973	4754905	Yes
2496	993	993.0	35.13	35.1	The structure of common mental disorders.	R F Krueger	Arch Gen Psychiatry	1999	10530634	Yes
2497	993	993.0	25.99	26.0	Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis.	R Balfour Sartor	Nat Clin Pract Gastroenterol Hepatol	2006	16819502	No
2498	993	993.0	34.83	34.8	Persister cells.	Kim Lewis	Annu Rev Microbiol	2010	20528688	No
2499	2979	993.0	135.93	45.3	Multiple imputation using chained equations: Issues and guidance for practice.	Ian R White, Patrick Royston, Angela M Wood	Stat Med	2011	21225900	Yes
2500	2977	992.3	76.27	25.4	Evolution and functions of long noncoding RNAs.	Chris P Ponting, Peter L Oliver, Wolf Reik	Cell	2009	19239885	No
2501	992	992.0	0.0	0.0	Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase.	H S Penefsky	J Biol Chem	1977	16006	Yes
2502	1984	992.0	68.43	34.2	Analysis of gene control signals by DNA fusion and cloning in Escherichia coli.	M J Casadaban, S N Cohen	J Mol Biol	1980	6997493	Yes
2503	992	992.0	27.77	27.8	Metabolism and functions of glutathione in brain.	R Dringen	Prog Neurobiol	2000	10880854	No
2504	1984	992.0	69.05	34.5	Accessories to the crime: functions of cells recruited to the tumor microenvironment.	Douglas Hanahan, Lisa M Coussens	Cancer Cell	2012	22439926	No
2505	6942	991.7	279.37	39.9	GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.	Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J Schünemann	BMJ	2008	18436948	Yes
2506	991	991.0	43.87	43.9	Lyme disease.	A C Steere	N Engl J Med	1989	2668764	No
2507	991	991.0	33.94	33.9	High prevalence of vitamin D inadequacy and implications for health.	Michael F Holick	Mayo Clin Proc	2006	16529140	No
2508	1982	991.0	48.88	24.4	Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis.	Jing Yang, Robert A Weinberg	Dev Cell	2008	18539112	No
2509	1981	990.5	45.89	22.9	Atherosclerosis. the road ahead.	C K Glass, J L Witztum	Cell	2001	11239408	No
2510	1981	990.5	50.29	25.1	Quorum sensing in bacteria.	M B Miller, B L Bassler	Annu Rev Microbiol	2001	11544353	No
2511	990	990.0	25.88	25.9	Plant salt tolerance.	J K Zhu	Trends Plant Sci	2001	11173290	Yes
2512	990	990.0	34.62	34.6	Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES).	Gunther Eysenbach	J Med Internet Res	2004	15471760	No
2513	990	990.0	22.02	22.0	Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution.	Sean B Carroll	Cell	2008	18614008	Yes
2514	1980	990.0	45.07	22.5	Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy.	S W Hell, J Wichmann	Opt Lett	1994	19844443	Yes
2515	990	990.0	40.03	40.0	Synopsis of some recent tactical application of bioisosteres in drug design.	Nicholas A Meanwell	J Med Chem	2011	21413808	Yes
2516	2969	989.7	85.47	28.5	Dystrophin: the protein product of the Duchenne muscular dystrophy locus.	E P Hoffman, R H Brown, L M Kunkel	Cell	1987	3319190	Yes
2517	989	989.0	0.0	0.0	The measurement of psychological androgyny.	S L Bem	J Consult Clin Psychol	1974	4823550	Yes
2518	2967	989.0	116.92	39.0	Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS.	B K Matuszewski, M L Constanzer, C M Chavez-Eng	Anal Chem	2003	12964746	Yes
2519	1978	989.0	0.0	0.0	Maximum utilization of the life table method in analyzing survival.	S J CUTLER, F EDERER	J Chronic Dis	1958	13598782	Yes
2520	1977	988.5	100.67	50.3	Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity.	P R Hunter, M A Gaston	J Clin Microbiol	1988	3069867	Yes
2521	1977	988.5	90.36	45.2	Neoantigens in cancer immunotherapy.	Ton N Schumacher, Robert D Schreiber	Science	2015	25838375	No
2522	8896	988.4	674.92	75.0	Cancer statistics in China, 2015.	Wanqing Chen, Rongshou Zheng, Peter D Baade, Siwei Zhang, Hongmei Zeng, Freddie Bray, Ahmedin Jemal, Xue Qin Yu, Jie He	CA Cancer J Clin	2016	26808342	Yes
2523	988	988.0	0.0	0.0	Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb.	J Altman	J Comp Neurol	1969	5361244	Yes
2524	988	988.0	23.32	23.3	Stem cells in the central nervous system.	R McKay	Science	1997	9082987	No
2525	988	988.0	25.66	25.7	Evaluating medication effects outside of clinical trials: new-user designs.	Wayne A Ray	Am J Epidemiol	2003	14585769	Yes
2526	988	988.0	36.77	36.8	Delirium in older persons.	Sharon K Inouye	N Engl J Med	2006	16540616	No
2527	1976	988.0	49.98	25.0	Next-generation DNA sequencing.	Jay Shendure, Hanlee Ji	Nat Biotechnol	2008	18846087	Yes
2528	988	988.0	39.37	39.4	The role of autophagy in neurodegenerative disease.	Ralph A Nixon	Nat Med	2013	23921753	No
2529	2962	987.3	101.26	33.8	Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections.	H King, R E Aubert, W H Herman	Diabetes Care	1998	9727886	Yes
2530	1974	987.0	43.22	21.6	Plant pathogens and integrated defence responses to infection.	J L Dangl, J D Jones	Nature	2001	11459065	No
2531	1973	986.5	91.18	45.6	The future of immune checkpoint therapy.	Padmanee Sharma, James P Allison	Science	2015	25838373	No
2532	986	986.0	32.78	32.8	Phylogenies from molecular sequences: inference and reliability.	J Felsenstein	Annu Rev Genet	1988	3071258	No
2533	986	986.0	25.09	25.1	Heterotrimeric G proteins: organizers of transmembrane signals.	E J Neer	Cell	1995	7834744	No
2534	986	986.0	20.29	20.3	Regulation of phosphoinositide-specific phospholipase C.	S G Rhee	Annu Rev Biochem	2001	11395409	No
2535	986	986.0	20.3	20.3	Microarray data normalization and transformation.	John Quackenbush	Nat Genet	2002	12454644	No
2536	985	985.0	29.66	29.7	The basic science of gene therapy.	R C Mulligan	Science	1993	8493530	No
2537	985	985.0	34.06	34.1	Modeling tracer kinetics in dynamic Gd-DTPA MR imaging.	P S Tofts	J Magn Reson Imaging	1997	9039598	No
2538	985	985.0	29.52	29.5	Persister cells, dormancy and infectious disease.	Kim Lewis	Nat Rev Microbiol	2007	17143318	No
2539	985	985.0	40.22	40.2	Volumetric modulated arc therapy: IMRT in a single gantry arc.	Karl Otto	Med Phys	2008	18293586	Yes
2540	1970	985.0	79.06	39.5	How good are my data and what is the resolution?	Philip R Evans, Garib N Murshudov	Acta Crystallogr D Biol Crystallogr	2013	23793146	Yes
2541	1969	984.5	0.0	0.0	Selective loss of central cholinergic neurons in Alzheimer's disease.	P Davies, A J Maloney	Lancet	1976	63862	Yes
2542	1969	984.5	63.36	31.7	Supercoil sequencing: a fast and simple method for sequencing plasmid DNA.	E Y Chen, P H Seeburg	DNA	1985	3996185	Yes
2543	1969	984.5	56.21	28.1	Statistical tests of neutrality of mutations.	Y X Fu, W H Li	Genetics	1993	8454210	Yes
2544	984	984.0	0.0	0.0	Drugs which inhibit prostaglandin biosynthesis.	R J Flower	Pharmacol Rev	1974	4208101	Yes
2545	984	984.0	49.72	49.7	Cardiac valve surgery--the "French correction".	A Carpentier	J Thorac Cardiovasc Surg	1983	6887954	Yes
2546	984	984.0	26.14	26.1	Allelic discrimination using fluorogenic probes and the 5' nuclease assay.	K J Livak	Genet Anal	1999	10084106	Yes
2547	984	984.0	25.58	25.6	Brain tumors.	L M DeAngelis	N Engl J Med	2001	11150363	No
2548	1967	983.5	45.98	23.0	Defining the role of mTOR in cancer.	David A Guertin, David M Sabatini	Cancer Cell	2007	17613433	No
2549	2950	983.3	73.96	24.7	Hepatocellular carcinoma.	Josep M Llovet, Andrew Burroughs, Jordi Bruix	Lancet	2003	14667750	No
2550	983	983.0	28.2	28.2	Molecular themes in oncogenesis.	J M Bishop	Cell	1991	1988146	No
2551	983	983.0	26.36	26.4	Oxyradicals and DNA damage.	L J Marnett	Carcinogenesis	2000	10688856	No
2552	2948	982.7	65.13	21.7	Large-scale analysis of the yeast proteome by multidimensional protein identification technology.	M P Washburn, D Wolters, J R Yates	Nat Biotechnol	2001	11231557	Yes
2553	2948	982.7	82.11	27.4	Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm.	Y Zhang, M Brady, S Smith	IEEE Trans Med Imaging	2001	11293691	Yes
2554	3930	982.5	140.68	35.2	Place navigation impaired in rats with hippocampal lesions.	R G Morris, P Garrud, J N Rawlins, J O'Keefe	Nature	1982	7088155	Yes
2555	1965	982.5	71.85	35.9	Oncology meets immunology: the cancer-immunity cycle.	Daniel S Chen, Ira Mellman	Immunity	2013	23890059	No
2556	1964	982.0	0.0	0.0	Radiological demarcation of cemented sockets in total hip replacement.	J G DeLee, J Charnley	Clin Orthop Relat Res	1976	991504	Yes
2557	982	982.0	19.66	19.7	Histone-deacetylase inhibitors: novel drugs for the treatment of cancer.	Ricky W Johnstone	Nat Rev Drug Discov	2002	12120280	No
2558	1964	982.0	0.0	0.0	Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines.	G J TODARO, H GREEN	J Cell Biol	1963	13985244	Yes
2559	1963	981.5	48.77	24.4	A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells.	N C Andrews, D V Faller	Nucleic Acids Res	1991	2041787	Yes
2560	981	981.0	42.21	42.2	The LMS method for constructing normalized growth standards.	T J Cole	Eur J Clin Nutr	1990	2354692	Yes
2561	981	981.0	26.11	26.1	Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration.	T A Springer	Annu Rev Physiol	1995	7778885	No
2562	981	981.0	22.32	22.3	Chromosomal translocations in human cancer.	T H Rabbitts	Nature	1994	7969446	No
2563	981	981.0	18.68	18.7	The development of neural stem cells.	S Temple	Nature	2001	11689956	No
2564	981	981.0	25.82	25.8	Optical microcavities.	Kerry J Vahala	Nature	2003	12917698	Yes
2565	981	981.0	20.45	20.4	Regulation of cadherin-mediated adhesion in morphogenesis.	Barry M Gumbiner	Nat Rev Mol Cell Biol	2005	16025097	No
2566	3921	980.2	100.43	25.1	SCOP: a structural classification of proteins database for the investigation of sequences and structures.	A G Murzin, S E Brenner, T Hubbard, C Chothia	J Mol Biol	1995	7723011	Yes
2567	4900	980.0	0.0	0.0	Transection of the oesophagus for bleeding oesophageal varices.	R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R Williams	Br J Surg	1973	4541913	Yes
2568	980	980.0	34.39	34.4	Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes.	W Sieghart	Pharmacol Rev	1995	7568326	No
2569	980	980.0	21.13	21.1	Inferences, questions and possibilities in Toll-like receptor signalling.	Bruce Beutler	Nature	2004	15241424	No
2570	2938	979.3	94.4	31.5	Molecular characterization of a peripheral receptor for cannabinoids.	S Munro, K L Thomas, M Abu-Shaar	Nature	1993	7689702	Yes
2571	979	979.0	53.97	54.0	Biomaterial-centered infection: microbial adhesion versus tissue integration.	A G Gristina	Science	1987	3629258	Yes
2572	979	979.0	33.39	33.4	Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies.	S L Friedman	N Engl J Med	1993	8502273	No
2573	979	979.0	21.64	21.6	Basement membranes: structure, assembly and role in tumour angiogenesis.	Raghu Kalluri	Nat Rev Cancer	2003	12778132	No
2574	978	978.0	0.0	0.0	Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.	J C Unkeless	J Exp Med	1979	90108	Yes
2575	978	978.0	34.68	34.7	Diversity of group types, regulation, and function of phospholipase A2.	E A Dennis	J Biol Chem	1994	8175726	No
2576	978	978.0	23.96	24.0	Target-oriented and diversity-oriented organic synthesis in drug discovery.	S L Schreiber	Science	2000	10720315	No
2577	978	978.0	23.29	23.3	The enzymes, regulation, and genetics of bile acid synthesis.	David W Russell	Annu Rev Biochem	2003	12543708	No
2578	1955	977.5	62.87	31.4	Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.	R G Phillips, J E LeDoux	Behav Neurosci	1992	1590953	Yes
2579	977	977.0	36.08	36.1	The aging process.	D Harman	Proc Natl Acad Sci U S A	1981	6947277	Yes
2580	977	977.0	22.04	22.0	Apoptosis in neurodegenerative disorders.	M P Mattson	Nat Rev Mol Cell Biol	2000	11253364	No
2581	977	977.0	0.0	0.0	The critical incident technique.	J C FLANAGAN	Psychol Bull	1954	13177800	Yes
2582	977	977.0	0.0	0.0	Intra-sexual selection in Drosophila.	A J BATEMAN	Heredity (Edinb)	1948	18103134	Yes
2583	2930	976.7	122.27	40.8	Hepatocellular carcinoma.	Alejandro Forner, Josep M Llovet, Jordi Bruix	Lancet	2012	22353262	No
2584	1953	976.5	84.96	42.5	Total energy intake: implications for epidemiologic analyses.	W Willett, M J Stampfer	Am J Epidemiol	1986	3521261	No
2585	1953	976.5	92.75	46.4	The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure.	R Näätänen, T Picton	Psychophysiology	1987	3615753	Yes
2586	1953	976.5	45.19	22.6	Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.	C W Greider, E H Blackburn	Cell	1985	3907856	Yes
2587	1953	976.5	58.89	29.4	Biology of incretins: GLP-1 and GIP.	Laurie L Baggio, Daniel J Drucker	Gastroenterology	2007	17498508	No
2588	976	976.0	63.61	63.6	The determinants of parenting: a process model.	J Belsky	Child Dev	1984	6705636	Yes
2589	3904	976.0	82.9	20.7	Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.	L Alexopoulou, A C Holt, R Medzhitov, R A Flavell	Nature	2001	11607032	Yes
2590	1952	976.0	68.21	34.1	Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio.	Aluísio J D Barros, Vânia N Hirakata	BMC Med Res Methodol	2003	14567763	Yes
2591	2927	975.7	67.65	22.6	Predicting coiled coils from protein sequences.	A Lupas, M Van Dyke, J Stock	Science	1991	2031185	Yes
2592	975	975.0	46.28	46.3	Multiple calcium channels and neuronal function.	R J Miller	Science	1987	2432656	No
2593	975	975.0	0.0	0.0	Dopamine (3-hydroxytyramine) and brain function.	O Hornykiewicz	Pharmacol Rev	1966	5328389	No
2594	975	975.0	31.34	31.3	Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications.	P Lips	Endocr Rev	2001	11493580	No
2595	975	975.0	0.0	0.0	A personality scale of manifest anxiety.	J A TAYLOR	J Abnorm Psychol	1953	13052352	Yes
2596	3896	974.0	126.19	31.5	Toxic potential of materials at the nanolevel.	Andre Nel, Tian Xia, Lutz Mädler, Ning Li	Science	2006	16456071	No
2597	974	974.0	0.0	0.0	A new readability yardstick.	R FLESCH	J Appl Psychol	1948	18867058	Yes
2598	1948	974.0	68.95	34.5	Chronic hepatitis B: update 2009.	Anna S F Lok, Brian J McMahon	Hepatology	2009	19714720	Yes
2599	3892	973.0	172.01	43.0	Guidelines for the process of cross-cultural adaptation of self-report measures.	D E Beaton, C Bombardier, F Guillemin, M B Ferraz	Spine (Phila Pa 1976)	2000	11124735	No
2600	973	973.0	22.96	23.0	Platelets in atherothrombosis.	Zaverio M Ruggeri	Nat Med	2002	12411949	No
2601	973	973.0	18.67	18.7	Biological robustness.	Hiroaki Kitano	Nat Rev Genet	2004	15520792	No
2602	5835	972.5	199.19	33.2	A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.	Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier	Science	2012	22745249	Yes
2603	972	972.0	0.0	0.0	Bee and wasp venoms.	E Habermann	Science	1972	4113805	No
2604	972	972.0	30.33	30.3	The neurobiology of stress: from serendipity to clinical relevance.	B S McEwen	Brain Res	2000	11119695	No
2605	972	972.0	62.98	63.0	The brain's default mode network.	Marcus E Raichle	Annu Rev Neurosci	2015	25938726	No
2606	1943	971.5	0.0	0.0	Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.	H J BLOOM, W W RICHARDSON	Br J Cancer	1957	13499785	Yes
2607	1942	971.0	69.47	34.7	A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data.	A Ennaceur, J Delacour	Behav Brain Res	1988	3228475	Yes
2608	971	971.0	35.21	35.2	The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.	A S Fauci	Science	1988	3277274	No
2609	971	971.0	24.48	24.5	Pedigree disequilibrium tests for multilocus haplotypes.	Frank Dudbridge	Genet Epidemiol	2003	12916020	Yes
2610	971	971.0	49.44	49.4	Working memory: theories, models, and controversies.	Alan Baddeley	Annu Rev Psychol	2012	21961947	No
2611	3883	970.8	99.61	24.9	A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.	Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry Sharpless	Angew Chem Int Ed Engl	2002	12203546	Yes
2612	1941	970.5	46.94	23.5	Synaptic activity and the construction of cortical circuits.	L C Katz, C J Shatz	Science	1996	8895456	No
2613	970	970.0	19.26	19.3	Antigen receptor tail clue.	M Reth	Nature	1989	2927501	Yes
2614	970	970.0	22.78	22.8	Prediction of protein cellular attributes using pseudo-amino acid composition.	K C Chou	Proteins	2001	11288174	Yes
2615	970	970.0	21.44	21.4	Protein tyrosine phosphatases: from genes, to function, to disease.	Nicholas K Tonks	Nat Rev Mol Cell Biol	2006	17057753	No
2616	1940	970.0	67.62	33.8	Natural products as sources of new drugs over the last 25 years.	David J Newman, Gordon M Cragg	J Nat Prod	2007	17309302	No
2617	970	970.0	30.84	30.8	Infection in solid-organ transplant recipients.	Jay A Fishman	N Engl J Med	2007	18094380	No
2618	970	970.0	57.21	57.2	Nonalcoholic fatty liver disease: a systematic review.	Mary E Rinella	JAMA	2015	26057287	No
2619	1939	969.5	71.07	35.5	Mediation in experimental and nonexperimental studies: new procedures and recommendations.	Patrick E Shrout, Niall Bolger	Psychol Methods	2002	12530702	Yes
2620	969	969.0	0.0	0.0	RNA metabolism in the HeLa cell nucleus.	S Penman	J Mol Biol	1966	5961144	Yes
2621	969	969.0	26.67	26.7	Neurons with graded response have collective computational properties like those of two-state neurons.	J J Hopfield	Proc Natl Acad Sci U S A	1984	6587342	Yes
2622	1938	969.0	76.02	38.0	Intracellular pH.	A Roos, W F Boron	Physiol Rev	1981	7012859	No
2623	968	968.0	44.13	44.1	The structure of beta-lactamases.	R P Ambler	Philos Trans R Soc Lond B Biol Sci	1980	6109327	Yes
2624	968	968.0	51.79	51.8	Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'.	Konrad M Andrassy	Kidney Int	2013	23989362	Yes
2625	2903	967.7	80.69	26.9	Functional diversity of helper T lymphocytes.	A K Abbas, K M Murphy, A Sher	Nature	1996	8893001	No
2626	2902	967.3	85.63	28.5	Methods in mammalian autophagy research.	Noboru Mizushima, Tamotsu Yoshimori, Beth Levine	Cell	2010	20144757	Yes
2627	967	967.0	33.32	33.3	Energy contributions of volatile fatty acids from the gastrointestinal tract in various species.	E N Bergman	Physiol Rev	1990	2181501	No
2628	967	967.0	31.94	31.9	The fetal and infant origins of adult disease.	D J Barker	BMJ	1990	2252919	No
2629	967	967.0	21.64	21.6	Regulation of transcription by MAP kinase cascades.	R Treisman	Curr Opin Cell Biol	1996	8791420	No
2630	967	967.0	19.84	19.8	The power and the promise of DNA methylation markers.	Peter W Laird	Nat Rev Cancer	2003	12671664	No
2631	1933	966.5	58.77	29.4	Apoptosis, oncosis, and necrosis. An overview of cell death.	G Majno, I Joris	Am J Pathol	1995	7856735	No
2632	1933	966.5	63.66	31.8	Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications.	Xiaobo Chen, Samuel S Mao	Chem Rev	2007	17590053	Yes
2633	966	966.0	23.01	23.0	Antigen-specific interaction between T and B cells.	A Lanzavecchia	Nature	1985	3157869	Yes
2634	966	966.0	42.67	42.7	The theoretical bases of indirect calorimetry: a review.	E Ferrannini	Metabolism	1988	3278194	No
2635	966	966.0	43.39	43.4	Linkage map of Escherichia coli K-12, edition 7.	B J Bachmann	Microbiol Rev	1983	6348505	No
2636	1932	966.0	62.24	31.1	Toll-like receptors and their crosstalk with other innate receptors in infection and immunity.	Taro Kawai, Shizuo Akira	Immunity	2011	21616434	No
2637	966	966.0	44.88	44.9	Cytokines in inflammatory bowel disease.	Markus F Neurath	Nat Rev Immunol	2014	24751956	No
2638	1931	965.5	57.57	28.8	Hydrogels for tissue engineering: scaffold design variables and applications.	Jeanie L Drury, David J Mooney	Biomaterials	2003	12922147	No
2639	2896	965.3	70.28	23.4	Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo.	Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen	Science	2005	15831717	Yes
2640	965	965.0	20.92	20.9	Mechanisms and consequences of activation of protein kinase B/Akt.	J Downward	Curr Opin Cell Biol	1998	9561851	No
2641	965	965.0	23.52	23.5	The myofibroblast in wound healing and fibrocontractive diseases.	G Gabbiani	J Pathol	2003	12845617	No
2642	1929	964.5	76.87	38.4	Modeling and comparison of dissolution profiles.	P Costa, J M Sousa Lobo	Eur J Pharm Sci	2001	11297896	No
2643	964	964.0	0.0	0.0	The interaction of a naphthalene dye with apomyoglobin and apohemoglobin. A fluorescent probe of non-polar binding sites.	L Stryer	J Mol Biol	1965	5867031	Yes
2644	964	964.0	32.2	32.2	The pollution of the marine environment by plastic debris: a review.	José G B Derraik	Mar Pollut Bull	2002	12405208	No
2645	964	964.0	20.11	20.1	Focal adhesion kinase: the first ten years.	J Thomas Parsons	J Cell Sci	2003	12640026	No
2646	964	964.0	21.59	21.6	Microsatellites: simple sequences with complex evolution.	Hans Ellegren	Nat Rev Genet	2004	15153996	No
2647	1927	963.5	52.55	26.3	Principles of bioactive lipid signalling: lessons from sphingolipids.	Yusuf A Hannun, Lina M Obeid	Nat Rev Mol Cell Biol	2008	18216770	No
2648	963	963.0	0.0	0.0	Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus.	P Rakic	J Comp Neurol	1971	4101340	Yes
2649	963	963.0	22.81	22.8	The finer things in X-ray diffraction data collection.	J W Pflugrath	Acta Crystallogr D Biol Crystallogr	1999	10531521	Yes
2650	963	963.0	17.38	17.4	Molecular mechanisms of axon guidance.	Barry J Dickson	Science	2002	12471249	No
2651	2887	962.3	79.52	26.5	Functional porous coordination polymers.	Susumu Kitagawa, Ryo Kitaura, Shin-ichiro Noro	Angew Chem Int Ed Engl	2004	15114565	Yes
2652	1924	962.0	39.33	19.7	An automated method for finding molecular complexes in large protein interaction networks.	Gary D Bader, Christopher W V Hogue	BMC Bioinformatics	2003	12525261	Yes
2653	961	961.0	40.37	40.4	Checklists for improving rigour in qualitative research: a case of the tail wagging the dog?	R S Barbour	BMJ	2001	11337448	No
2654	961	961.0	0.0	0.0	A modified ninhydrin colorimetric analysis for amino acids.	H ROSEN	Arch Biochem Biophys	1957	13412116	Yes
2655	1921	960.5	73.23	36.6	Modified RECIST (mRECIST) assessment for hepatocellular carcinoma.	Riccardo Lencioni, Josep M Llovet	Semin Liver Dis	2010	20175033	No
2656	960	960.0	0.0	0.0	Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol.	D B Clewell	J Bacteriol	1972	4336693	Yes
2657	960	960.0	53.31	53.3	Free-radical mechanisms in tissue injury.	T F Slater	Biochem J	1984	6383353	No
2658	960	960.0	32.78	32.8	Peptide antibiotics and their role in innate immunity.	H G Boman	Annu Rev Immunol	1995	7612236	No
2659	1920	960.0	57.09	28.5	Genetic dissection of complex traits.	E S Lander, N J Schork	Science	1994	8091226	No
2660	960	960.0	33.75	33.8	Inferring microstructural features and the physiological state of tissues from diffusion-weighted images.	P J Basser	NMR Biomed	1995	8739270	No
2661	960	960.0	32.18	32.2	Papillary and follicular thyroid carcinoma.	M J Schlumberger	N Engl J Med	1998	9445411	No
2662	1920	960.0	53.41	26.7	C-reactive protein: a critical update.	Mark B Pepys, Gideon M Hirschfield	J Clin Invest	2003	12813013	No
2663	1920	960.0	48.93	24.5	Cellular processing of platinum anticancer drugs.	Dong Wang, Stephen J Lippard	Nat Rev Drug Discov	2005	15789122	No
2664	1920	960.0	67.85	33.9	Health effects of fine particulate air pollution: lines that connect.	C Arden Pope, Douglas W Dockery	J Air Waste Manag Assoc	2006	16805397	No
2665	959	959.0	32.81	32.8	The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure.	K Kuwajima	Proteins	1989	2695928	No
2666	959	959.0	30.45	30.4	Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.	C Taswell	J Immunol	1981	7009746	Yes
2667	959	959.0	33.18	33.2	The somatic marker hypothesis and the possible functions of the prefrontal cortex.	A R Damasio	Philos Trans R Soc Lond B Biol Sci	1996	8941953	No
2668	958	958.0	60.71	60.7	Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale.	Anna Maria Carlsson	Pain	1983	6602967	Yes
2669	958	958.0	28.14	28.1	Drug delivery and targeting.	R Langer	Nature	1998	9579855	No
2670	958	958.0	0.0	0.0	A NEW WEIGHTING SYSTEM FOR MEAN SURFACE TEMPERATURE OF THE HUMAN BODY.	N L RAMANATHAN	J Appl Physiol	1964	14173555	Yes
2671	958	958.0	23.41	23.4	How neutrophils kill microbes.	Anthony W Segal	Annu Rev Immunol	2005	15771570	No
2672	958	958.0	32.8	32.8	Deconvoluting the context-dependent role for autophagy in cancer.	Eileen White	Nat Rev Cancer	2012	22534666	No
2673	1915	957.5	0.0	0.0	Surgical risk as related to time of intervention in the repair of intracranial aneurysms.	W E Hunt, R M Hess	J Neurosurg	1968	5635959	Yes
2674	957	957.0	21.04	21.0	Liver regeneration: from myth to mechanism.	Rebecca Taub	Nat Rev Mol Cell Biol	2004	15459664	No
2675	1914	957.0	46.92	23.5	Blinded by the Light: The Growing Complexity of p53.	Karen H Vousden, Carol Prives	Cell	2009	19410540	No
2676	1912	956.0	0.0	0.0	Method for the isolation of intact islets of Langerhans from the rat pancreas.	P E Lacy, M Kostianovsky	Diabetes	1967	5333500	Yes
2677	956	956.0	25.74	25.7	Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase.	P Kuzmic	Anal Biochem	1996	8660575	Yes
2678	956	956.0	0.0	0.0	On the Absorption of Fluids from the Connective Tissue Spaces.	E H Starling	J Physiol	1896	16992325	Yes
2679	2867	955.7	55.64	18.5	Molecular genetic analysis of fission yeast Schizosaccharomyces pombe.	S Moreno, A Klar, P Nurse	Methods Enzymol	1991	2005825	Yes
2680	1911	955.5	51.44	25.7	Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival.	Josep M Llovet, Jordi Bruix	Hepatology	2003	12540794	No
2681	1911	955.5	55.17	27.6	Morris water maze: procedures for assessing spatial and related forms of learning and memory.	Charles V Vorhees, Michael T Williams	Nat Protoc	2006	17406317	Yes
2682	955	955.0	28.85	28.9	Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology.	E M Tan	Adv Immunol	1989	2646863	No
2683	955	955.0	46.49	46.5	Neuropeptide Y: complete amino acid sequence of the brain peptide.	K Tatemoto	Proc Natl Acad Sci U S A	1982	6957876	Yes
2684	1909	954.5	47.61	23.8	Esophageal cancer.	Peter C Enzinger, Robert J Mayer	N Engl J Med	2003	14657432	No
2685	954	954.0	0.0	0.0	Experience from a multicentre stroke register: a preliminary report.	S Hatano	Bull World Health Organ	1976	1088404	Yes
2686	1908	954.0	0.0	0.0	Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G.	E Engvall, P Perlmann	Immunochemistry	1971	5135623	Yes
2687	3815	953.8	96.85	24.2	Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.	G L Wang, B H Jiang, E A Rue, G L Semenza	Proc Natl Acad Sci U S A	1995	7539918	Yes
2688	1907	953.5	66.15	33.1	Recent advances in the phencyclidine model of schizophrenia.	D C Javitt, S R Zukin	Am J Psychiatry	1991	1654746	No
2689	13348	953.4	318.74	22.8	Crystallography & NMR system: A new software suite for macromolecular structure determination.	A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L Warren	Acta Crystallogr D Biol Crystallogr	1998	9757107	Yes
2690	953	953.0	46.22	46.2	Biology of interleukin 1.	C A Dinarello	FASEB J	1988	3277884	No
2691	953	953.0	33.61	33.6	The Hospital Anxiety And Depression Scale.	R Philip Snaith	Health Qual Life Outcomes	2003	12914662	Yes
2692	953	953.0	20.75	20.8	Automated NMR structure calculation with CYANA.	Peter Güntert	Methods Mol Biol	2004	15318003	Yes
2693	953	953.0	33.02	33.0	phangorn: phylogenetic analysis in R.	Klaus Peter Schliep	Bioinformatics	2011	21169378	Yes
2694	953	953.0	35.54	35.5	Thermal properties of graphene and nanostructured carbon materials.	Alexander A Balandin	Nat Mater	2011	21778997	Yes
2695	1905	952.5	92.91	46.5	A simple method to assess exercise behavior in the community.	G Godin, R J Shephard	Can J Appl Sport Sci	1985	4053261	Yes
2696	1905	952.5	51.15	25.6	Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology.	M E Feder, G E Hofmann	Annu Rev Physiol	1999	10099689	No
2697	1905	952.5	60.84	30.4	Tumor metastasis: molecular insights and evolving paradigms.	Scott Valastyan, Robert A Weinberg	Cell	2011	22000009	No
2698	4762	952.4	287.51	57.5	Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee.	N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W Stitt	J Rheumatol	1988	3068365	Yes
2699	952	952.0	35.15	35.1	Relations between the statistics of natural images and the response properties of cortical cells.	D J Field	J Opt Soc Am A	1987	3430225	Yes
2700	952	952.0	28.04	28.0	Disorders of iron metabolism.	N C Andrews	N Engl J Med	1999	10607817	No
2701	952	952.0	21.31	21.3	Osmotic stress signaling and osmoadaptation in yeasts.	Stefan Hohmann	Microbiol Mol Biol Rev	2002	12040128	No
2702	5712	952.0	186.61	31.1	Cancer statistics, 2007.	Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Taylor Murray, Jiaquan Xu, Michael J Thun	CA Cancer J Clin	2007	17237035	Yes
2703	952	952.0	38.38	38.4	AmpC beta-lactamases.	George A Jacoby	Clin Microbiol Rev	2009	19136439	No
2704	951	951.0	32.42	32.4	MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship.	Amy E Pasquinelli	Nat Rev Genet	2012	22411466	No
2705	5701	950.2	194.13	32.4	Free radicals and antioxidants in normal physiological functions and human disease.	Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua Telser	Int J Biochem Cell Biol	2007	16978905	No
2706	1900	950.0	45.85	22.9	Lymphocyte homing and homeostasis.	E C Butcher, L J Picker	Science	1996	8600538	No
2707	950	950.0	19.64	19.6	The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities.	Y Yarden	Eur J Cancer	2001	11597398	No
2708	950	950.0	26.43	26.4	Comparative physiology of salt and water stress.	R. Munns	Plant Cell Environ	2002	11841667	Yes
2709	950	950.0	21.55	21.6	Phenotypic plasticity and the epigenetics of human disease.	Andrew P Feinberg	Nature	2007	17522677	No
2710	1899	949.5	64.35	32.2	Nitric oxide synthases: roles, tolls, and controls.	C Nathan, Q W Xie	Cell	1994	7522969	No
2711	2848	949.3	112.04	37.3	Qualitative research in health care. Analysing qualitative data.	C Pope, S Ziebland, N Mays	BMJ	2000	10625273	No
2712	949	949.0	48.57	48.6	Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC.	G A McPherson	J Pharmacol Methods	1985	3840547	Yes
2713	949	949.0	35.79	35.8	Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing.	M J Gasson	J Bacteriol	1983	6403500	Yes
2714	949	949.0	24.33	24.3	A tension-based theory of morphogenesis and compact wiring in the central nervous system.	D C Van Essen	Nature	1997	9002514	Yes
2715	949	949.0	25.31	25.3	Context and behavioral processes in extinction.	Mark E Bouton	Learn Mem	2004	15466298	No
2716	949	949.0	26.59	26.6	Recent advances in neuroblastoma.	John M Maris	N Engl J Med	2010	20558371	No
2717	1897	948.5	80.2	40.1	Atomic structure and chemistry of human serum albumin.	X M He, D C Carter	Nature	1992	1630489	Yes
2718	948	948.0	20.75	20.8	Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution.	Z Yang	Mol Biol Evol	1998	9580986	Yes
2719	948	948.0	0.0	0.0	Starch gel electrophoresis in a discontinous system of buffers.	M D POULIK	Nature	1957	13493570	Yes
2720	948	948.0	25.18	25.2	Anatomy and regulation of the central melanocortin system.	Roger D Cone	Nat Neurosci	2005	15856065	No
2721	948	948.0	22.15	22.1	Membrane recognition by phospholipid-binding domains.	Mark A Lemmon	Nat Rev Mol Cell Biol	2008	18216767	No
2722	948	948.0	19.6	19.6	ChIP-seq: advantages and challenges of a maturing technology.	Peter J Park	Nat Rev Genet	2009	19736561	No
2723	947	947.0	0.0	0.0	Regulation of noradrenaline release by presynaptic receptor systems.	K Starke	Rev Physiol Biochem Pharmacol	1977	14389	No
2724	947	947.0	0.0	0.0	Cellular resistance to infection.	G B MACKANESS	J Exp Med	1962	14467923	Yes
2725	947	947.0	35.46	35.5	Platelet-rich plasma: evidence to support its use.	Robert E Marx	J Oral Maxillofac Surg	2004	15085519	No
2726	947	947.0	0.0	0.0	THE FUNCTION OF THE VERTEBRAL VEINS AND THEIR ROLE IN THE SPREAD OF METASTASES.	O V Batson	Ann Surg	1940	17857618	Yes
2727	947	947.0	36.29	36.3	Electrocatalyst approaches and challenges for automotive fuel cells.	Mark K Debe	Nature	2012	22678278	Yes
2728	7571	946.4	226.76	28.3	A method and server for predicting damaging missense mutations.	Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R Sunyaev	Nat Methods	2010	20354512	Yes
2729	946	946.0	0.0	0.0	Sequential tests for the detection of linkage.	N E MORTON	Am J Hum Genet	1955	13258560	Yes
2730	1892	946.0	48.68	24.3	Cell cycle, CDKs and cancer: a changing paradigm.	Marcos Malumbres, Mariano Barbacid	Nat Rev Cancer	2009	19238148	No
2731	946	946.0	25.1	25.1	Tumour necrosis factor and cancer.	Frances Balkwill	Nat Rev Cancer	2009	19343034	No
2732	3783	945.8	123.08	30.8	Prevalence and trends in obesity among US adults, 1999-2000.	Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L Johnson	JAMA	2002	12365955	Yes
2733	1891	945.5	39.69	19.8	Proliferation, cell cycle and apoptosis in cancer.	G I Evan, K H Vousden	Nature	2001	11357141	No
2734	10396	945.1	311.76	28.3	The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data.	Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristo	Genome Res	2010	20644199	Yes
2735	945	945.0	47.21	47.2	Bone "mass" and the "mechanostat": a proposal.	H M Frost	Anat Rec	1987	3688455	Yes
2736	1890	945.0	136.28	68.1	The amyloid hypothesis of Alzheimer's disease at 25 years.	Dennis J Selkoe, John Hardy	EMBO Mol Med	2016	27025652	No
2737	1889	944.5	0.0	0.0	Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty.	J M Tanner, R H Whitehouse	Arch Dis Child	1976	952550	Yes
2738	944	944.0	36.62	36.6	Diversity and ubiquity of K channels.	B Rudy	Neuroscience	1988	2457185	No
2739	944	944.0	42.35	42.4	Carnitine--metabolism and functions.	J Bremer	Physiol Rev	1983	6361812	No
2740	944	944.0	18.28	18.3	Regulatory T cells in autoimmmunity*.	E M Shevach	Annu Rev Immunol	2000	10837065	No
2741	944	944.0	27.65	27.6	Functionalized acenes and heteroacenes for organic electronics.	John E Anthony	Chem Rev	2006	17165682	Yes
2742	944	944.0	21.47	21.5	Up on the tightrope: natural killer cell activation and inhibition.	Lewis L Lanier	Nat Immunol	2008	18425106	No
2743	944	944.0	23.2	23.2	Personal genomes: The case of the missing heritability.	Brendan Maher	Nature	2008	18987709	No
2744	944	944.0	37.08	37.1	Tumor delivery of macromolecular drugs based on the EPR effect.	Vladimir Torchilin	Adv Drug Deliv Rev	2011	20304019	No
2745	3773	943.2	0.0	0.0	The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes.	L A Sternberger, P H Hardy, J J Cuculis, H G Meyer	J Histochem Cytochem	1970	4192899	Yes
2746	943	943.0	0.0	0.0	An improved procedure for serum creatine phosphokinase determination.	S B Rosalki	J Lab Clin Med	1967	4381359	Yes
2747	943	943.0	23.85	23.9	Translating cell biology into therapeutic advances in Alzheimer's disease.	D J Selkoe	Nature	1999	10392577	No
2748	1886	943.0	56.11	28.1	Chlorophyll fluorescence--a practical guide.	K Maxwell, G N Johnson	J Exp Bot	2000	10938857	No
2749	1886	943.0	40.66	20.3	Genomic control for association studies.	B Devlin, K Roeder	Biometrics	1999	11315092	Yes
2750	943	943.0	19.92	19.9	mTOR and cancer: insights into a complex relationship.	David M Sabatini	Nat Rev Cancer	2006	16915295	No
2751	4714	942.8	101.11	20.2	Electrostatics of nanosystems: application to microtubules and the ribosome.	N A Baker, D Sept, S Joseph, M J Holst, J A McCammon	Proc Natl Acad Sci U S A	2001	11517324	Yes
2752	2828	942.7	83.76	27.9	Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya.	C R Woese, O Kandler, M L Wheelis	Proc Natl Acad Sci U S A	1990	2112744	Yes
2753	1885	942.5	44.41	22.2	The significance of digital gene expression profiles.	S Audic, J M Claverie	Genome Res	1997	9331369	Yes
2754	1885	942.5	40.06	20.0	Tumour-cell invasion and migration: diversity and escape mechanisms.	Peter Friedl, Katarina Wolf	Nat Rev Cancer	2003	12724734	No
2755	942	942.0	0.0	0.0	Mutation selection and the natural history of cancer.	J Cairns	Nature	1975	1143315	Yes
2756	942	942.0	34.57	34.6	Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.	L A Liotta	Cancer Res	1986	2998604	No
2757	942	942.0	0.0	0.0	Protein denaturation. C. Theoretical models for the mechanism of denaturation.	C Tanford	Adv Protein Chem	1970	4912353	No
2758	942	942.0	16.91	16.9	Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism.	M S Wold	Annu Rev Biochem	1997	9242902	No
2759	942	942.0	26.25	26.2	P-450 metabolites of arachidonic acid in the control of cardiovascular function.	Richard J Roman	Physiol Rev	2002	11773611	No
2760	942	942.0	16.95	16.9	Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation.	Eric C Lai	Nat Genet	2002	11896390	Yes
2761	2826	942.0	85.56	28.5	Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion.	Robert D Schreiber, Lloyd J Old, Mark J Smyth	Science	2011	21436444	No
2762	941	941.0	29.34	29.3	Inhibition of return.	Klein	Trends Cogn Sci	2000	10740278	Yes
2763	941	941.0	46.61	46.6	α-band oscillations, attention, and controlled access to stored information.	Wolfgang Klimesch	Trends Cogn Sci	2012	23141428	No
2764	3764	941.0	241.15	60.3	IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies.	Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang Minh	Mol Biol Evol	2015	25371430	Yes
2765	3763	940.8	103.64	25.9	Functional connectivity in the resting brain: a network analysis of the default mode hypothesis.	Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod Menon	Proc Natl Acad Sci U S A	2003	12506194	Yes
2766	1881	940.5	57.53	28.8	EasySpin, a comprehensive software package for spectral simulation and analysis in EPR.	Stefan Stoll, Arthur Schweiger	J Magn Reson	2006	16188474	Yes
2767	1881	940.5	52.07	26.0	Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm.	Subhra K Biswas, Alberto Mantovani	Nat Immunol	2010	20856220	No
2768	940	940.0	0.0	0.0	Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies.	S Avrameas	Immunochemistry	1969	4975324	Yes
2769	940	940.0	46.95	47.0	Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment.	S H Safe	Crit Rev Toxicol	1994	8037844	No
2770	1880	940.0	79.03	39.5	Physiological parameters in laboratory animals and humans.	B Davies, T Morris	Pharm Res	1993	8378254	No
2771	940	940.0	32.36	32.4	Electrochemical glucose biosensors.	Joseph Wang	Chem Rev	2008	18154363	No
2772	939	939.0	24.81	24.8	Differential projections of the infralimbic and prelimbic cortex in the rat.	Robert P Vertes	Synapse	2004	14579424	Yes
2773	1878	939.0	66.62	33.3	Inflammatory mechanisms in obesity.	Margaret F Gregor, Gökhan S Hotamisligil	Annu Rev Immunol	2011	21219177	No
2774	1877	938.5	48.77	24.4	Modes of resistance to anti-angiogenic therapy.	Gabriele Bergers, Douglas Hanahan	Nat Rev Cancer	2008	18650835	No
2775	938	938.0	51.5	51.5	Substance P.	B Pernow	Pharmacol Rev	1983	6196797	No
2776	938	938.0	34.71	34.7	Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology.	J J Gross	J Pers Soc Psychol	1998	9457784	Yes
2777	1876	938.0	77.69	38.8	Functional interactions between the gut microbiota and host metabolism.	Valentina Tremaroli, Fredrik Bäckhed	Nature	2012	22972297	No
2778	937	937.0	35.01	35.0	The matrix-degrading metalloproteinases.	L M Matrisian	Bioessays	1992	1445287	No
2779	1874	937.0	97.83	48.9	Biology of disease: free radicals and tissue injury.	B A Freeman, J D Crapo	Lab Invest	1982	6290784	No
2780	937	937.0	22.63	22.6	The columnar organization of the neocortex.	V B Mountcastle	Brain	1997	9153131	No
2781	937	937.0	23.07	23.1	Complement. Second of two parts.	M J Walport	N Engl J Med	2001	11297706	No
2782	937	937.0	27.51	27.5	Molecular genetics of colorectal cancer.	Eric R Fearon	Annu Rev Pathol	2011	21090969	No
2783	1873	936.5	55.58	27.8	Molecular mechanisms of action of steroid/thyroid receptor superfamily members.	M J Tsai, B W O'Malley	Annu Rev Biochem	1994	7979245	No
2784	936	936.0	60.59	60.6	The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction.	G A Ilizarov	Clin Orthop Relat Res	1989	2912628	Yes
2785	936	936.0	0.0	0.0	Simple methods for "staining with lead" at high pH in electron microscopy.	M J KARNOVSKY	J Biophys Biochem Cytol	1961	14454024	Yes
2786	4679	935.8	189.76	38.0	Posttraumatic stress disorder in the National Comorbidity Survey.	R C Kessler, A Sonnega, E Bromet, M Hughes, C B Nelson	Arch Gen Psychiatry	1995	7492257	Yes
2787	1871	935.5	40.1	20.1	Community structure in social and biological networks.	M Girvan, M E J Newman	Proc Natl Acad Sci U S A	2002	12060727	No
2788	1871	935.5	84.19	42.1	PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data.	Daniel R Roe, Thomas E Cheatham	J Chem Theory Comput	2013	26583988	Yes
2789	935	935.0	31.72	31.7	General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.	R A Houghten	Proc Natl Acad Sci U S A	1985	2410914	Yes
2790	935	935.0	28.56	28.6	Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes.	M Kozak	Nucleic Acids Res	1981	7301588	Yes
2791	2805	935.0	105.02	35.0	Oxidants, antioxidants, and the degenerative diseases of aging.	B N Ames, M K Shigenaga, T M Hagen	Proc Natl Acad Sci U S A	1993	8367443	No
2792	935	935.0	23.9	23.9	Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial.	H J Dargie	Lancet	2001	11356434	Yes
2793	935	935.0	44.96	45.0	What is self-rated health and why does it predict mortality? Towards a unified conceptual model.	Marja Jylhä	Soc Sci Med	2009	19520474	Yes
2794	935	935.0	51.98	52.0	Environmentally induced oxidative stress in aquatic animals.	Volodymyr I Lushchak	Aquat Toxicol	2011	21074869	No
2795	4675	935.0	196.19	39.2	The hallmarks of aging.	Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer	Cell	2013	23746838	No
2796	934	934.0	54.53	54.5	A cognitive approach to panic.	D M Clark	Behav Res Ther	1986	3741311	Yes
2797	934	934.0	29.88	29.9	The effects of stressful life events on depression.	R C Kessler	Annu Rev Psychol	1997	9046559	No
2798	934	934.0	30.08	30.1	Leishmaniasis.	B L Herwaldt	Lancet	1999	10513726	No
2799	1867	933.5	33.79	16.9	A synthetic oscillatory network of transcriptional regulators.	M B Elowitz, S Leibler	Nature	2000	10659856	Yes
2800	2800	933.3	83.82	27.9	A nonparametric method for automatic correction of intensity nonuniformity in MRI data.	J G Sled, A P Zijdenbos, A C Evans	IEEE Trans Med Imaging	1998	9617910	Yes
2801	1866	933.0	43.06	21.5	Checkpoints: controls that ensure the order of cell cycle events.	L H Hartwell, T A Weinert	Science	1989	2683079	No
2802	933	933.0	21.14	21.1	An overview of epithelio-mesenchymal transformation.	E D Hay	Acta Anat (Basel)	1995	8714286	No
2803	1866	933.0	45.04	22.5	Regeneration beyond the glial scar.	Jerry Silver, Jared H Miller	Nat Rev Neurosci	2004	14735117	No
2804	1865	932.5	160.76	80.4	Facial nerve grading system.	J W House, D E Brackmann	Otolaryngol Head Neck Surg	1985	3921901	Yes
2805	1865	932.5	59.07	29.5	ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control.	Graham Noctor, Christine H. Foyer	Annu Rev Plant Physiol Plant Mol Biol	1998	15012235	Yes
2806	5595	932.5	137.44	22.9	Principal components analysis corrects for stratification in genome-wide association studies.	Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David Reich	Nat Genet	2006	16862161	Yes
2807	2797	932.3	98.27	32.8	SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building.	Manolo Gouy, Stéphane Guindon, Olivier Gascuel	Mol Biol Evol	2010	19854763	Yes
2808	932	932.0	46.72	46.7	Freezing of living cells: mechanisms and implications.	P Mazur	Am J Physiol	1984	6383068	No
2809	932	932.0	0.0	0.0	Method for the determination of hexosamines in tissues.	N F BOAS	J Biol Chem	1953	13117829	Yes
2810	931	931.0	0.0	0.0	Why people use health services.	I M Rosenstock	Milbank Mem Fund Q	1966	5967464	Yes
2811	931	931.0	31.39	31.4	Stronger Brønsted acids.	Takahiko Akiyama	Chem Rev	2007	17983247	Yes
2812	1860	930.0	0.0	0.0	A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants.	R L Juliano, V Ling	Biochim Biophys Acta	1976	990323	Yes
2813	1860	930.0	64.85	32.4	Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report.	P Brugada, J Brugada	J Am Coll Cardiol	1992	1309182	Yes
2814	930	930.0	36.23	36.2	Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations.	Ronald A Hites	Environ Sci Technol	2004	14998004	Yes
2815	930	930.0	35.66	35.7	Amino acids: metabolism, functions, and nutrition.	Guoyao Wu	Amino Acids	2009	19301095	No
2816	1860	930.0	95.51	47.8	Alginate: properties and biomedical applications.	Kuen Yong Lee, David J Mooney	Prog Polym Sci	2012	22125349	Yes
2817	929	929.0	42.17	42.2	The P300 wave of the human event-related potential.	T W Picton	J Clin Neurophysiol	1992	1464675	No
2818	929	929.0	62.82	62.8	Psychosocial resilience and protective mechanisms.	Michael Rutter	Am J Orthopsychiatry	1987	3303954	No
2819	929	929.0	22.38	22.4	Molecular imaging of cancer with positron emission tomography.	Sanjiv Sam Gambhir	Nat Rev Cancer	2002	12209157	No
2820	3714	928.5	105.95	26.5	C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women.	P M Ridker, C H Hennekens, J E Buring, N Rifai	N Engl J Med	2000	10733371	Yes
2821	3713	928.2	104.32	26.1	An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets.	Joseph A Maldjian, Paul J Laurienti, Robert A Kraft, Jonathan H Burdette	Neuroimage	2003	12880848	Yes
2822	928	928.0	27.25	27.2	Two-stage model of memory trace formation: a role for "noisy" brain states.	G Buzsáki	Neuroscience	1989	2687720	No
2823	928	928.0	35.14	35.1	Effect of anoxia on ion distribution in the brain.	A J Hansen	Physiol Rev	1985	3880896	No
2824	928	928.0	22.02	22.0	Measuring information transfer	Schreiber	Phys Rev Lett	2000	10991308	Yes
2825	1855	927.5	42.55	21.3	Dynamic instability of microtubule growth.	T Mitchison, M Kirschner	Nature	1984	6504138	Yes
2826	3709	927.2	134.07	33.5	Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.	N Weidner, J P Semple, W R Welch, J Folkman	N Engl J Med	1991	1701519	Yes
2827	927	927.0	22.5	22.5	MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation.	R N Germain	Cell	1994	8293464	No
2828	927	927.0	27.1	27.1	Supported membranes: scientific and practical applications.	E Sackmann	Science	1996	8539599	No
2829	927	927.0	30.26	30.3	Cholinesterase inhibitors for Alzheimer's disease.	J Birks	Cochrane Database Syst Rev	2006	16437532	No
2830	5560	926.7	230.33	38.4	Antioxidant activity applying an improved ABTS radical cation decolorization assay.	R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-Evans	Free Radic Biol Med	1999	10381194	Yes
2831	1853	926.5	0.0	0.0	Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome.	C B Lozzio, B B Lozzio	Blood	1975	163658	Yes
2832	1853	926.5	43.01	21.5	The Hsp70 and Hsp60 chaperone machines.	B Bukau, A L Horwich	Cell	1998	9476895	No
2833	1853	926.5	46.42	23.2	Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set.	N Sreerama, R W Woody	Anal Biochem	2000	11112271	Yes
2834	926	926.0	0.0	0.0	Studies on phosphatidylcholine vesicles. Formation and physical characteristics.	C Huang	Biochemistry	1969	5777332	Yes
2835	1852	926.0	76.15	38.1	Unidentified curved bacilli on gastric epithelium in active chronic gastritis.	J R Warren, B Marshall	Lancet	1983	6134060	Yes
2836	926	926.0	25.96	26.0	Looking into the functional architecture of the brain with diffusion MRI.	Denis Le Bihan	Nat Rev Neurosci	2003	12778119	No
2837	926	926.0	27.97	28.0	Thermo- and pH-responsive polymers in drug delivery.	Dirk Schmaljohann	Adv Drug Deliv Rev	2006	17125884	No
2838	925	925.0	29.57	29.6	Pathogenesis of dengue: challenges to molecular biology.	S B Halstead	Science	1988	3277268	No
2839	925	925.0	0.0	0.0	Origin of concatemeric T7 DNA.	J D Watson	Nat New Biol	1972	4507727	Yes
2840	1850	925.0	54.93	27.5	Oxidative stress, caloric restriction, and aging.	R S Sohal, R Weindruch	Science	1996	8658196	No
2841	925	925.0	19.91	19.9	VEGF and the quest for tumour angiogenesis factors.	Napoleone Ferrara	Nat Rev Cancer	2002	12360282	No
2842	925	925.0	23.33	23.3	G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry.	Jeffery T Davis	Angew Chem Int Ed Engl	2004	14755695	No
2843	924	924.0	0.0	0.0	The prevalence of 'alexithymic' characteristics in psychosomatic patients.	P E Sifneos	Psychother Psychosom	1973	4770536	Yes
2844	924	924.0	29.98	30.0	Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.	J Deisenhofer	Biochemistry	1981	7236608	Yes
2845	924	924.0	32.74	32.7	Context, time, and memory retrieval in the interference paradigms of Pavlovian learning.	M E Bouton	Psychol Bull	1993	8346330	No
2846	923	923.0	28.62	28.6	The mitochondrial electron transport and oxidative phosphorylation system.	Y Hatefi	Annu Rev Biochem	1985	2862839	No
2847	923	923.0	26.21	26.2	Automatic quantitation of localized in vivo 1H spectra with LCModel.	S W Provencher	NMR Biomed	2001	11410943	Yes
2848	1846	923.0	49.66	24.8	A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure.	J N Cohn, G Tognoni	N Engl J Med	2001	11759645	Yes
2849	923	923.0	21.46	21.5	Oxidant signals and oxidative stress.	Toren Finkel	Curr Opin Cell Biol	2003	12648682	No
2850	923	923.0	29.77	29.8	Disseminating innovations in health care.	Donald M Berwick	JAMA	2003	12697800	Yes
2851	1846	923.0	66.05	33.0	Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC).	Kathryn M Connor, Jonathan R T Davidson	Depress Anxiety	2003	12964174	Yes
2852	923	923.0	29.5	29.5	A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors.	Ron Hardman	Environ Health Perspect	2006	16451849	No
2853	4615	923.0	704.69	140.9	MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms.	Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro Tamura	Mol Biol Evol	2018	29722887	Yes
2854	2768	922.7	185.05	61.7	Some statistical methods useful in circulation research.	S Wallenstein, C L Zucker, J L Fleiss	Circ Res	1980	7379260	Yes
2855	1845	922.5	61.78	30.9	Heterogeneous photocatalyst materials for water splitting.	Akihiko Kudo, Yugo Miseki	Chem Soc Rev	2009	19088977	Yes
2856	1845	922.5	43.98	22.0	Regulation of translation initiation in eukaryotes: mechanisms and biological targets.	Nahum Sonenberg, Alan G Hinnebusch	Cell	2009	19239892	No
2857	1844	922.0	58.49	29.2	Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications.	M A Pfeffer, E Braunwald	Circulation	1990	2138525	No
2858	4610	922.0	92.09	18.4	The protein kinase complement of the human genome.	G Manning, D B Whyte, R Martinez, T Hunter, S Sudarsanam	Science	2002	12471243	No
2859	922	922.0	28.28	28.3	Epidemiology of women and depression.	Ronald C Kessler	J Affect Disord	2003	12646294	Yes
2860	922	922.0	29.52	29.5	Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis.	P Vestergaard	Osteoporos Int	2007	17068657	No
2861	922	922.0	33.98	34.0	Understanding diagnostic tests 3: Receiver operating characteristic curves.	Anthony K Akobeng	Acta Paediatr	2007	17376185	No
2862	7373	921.6	249.01	31.1	The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment.	Ziad S Nasreddine, Natalie A Phillips, Valérie Bédirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard Chertkow	J Am Geriatr Soc	2005	15817019	Yes
2863	1843	921.5	48.24	24.1	Inflammation, stress, and diabetes.	Kathryn E Wellen, Gökhan S Hotamisligil	J Clin Invest	2005	15864338	No
2864	1843	921.5	68.25	34.1	Insights into the regulation of protein abundance from proteomic and transcriptomic analyses.	Christine Vogel, Edward M Marcotte	Nat Rev Genet	2012	22411467	No
2865	921	921.0	0.0	0.0	Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action.	J H Luft	Anat Rec	1971	4108333	Yes
2866	921	921.0	0.0	0.0	Cell lines derived from late embryonic stages of Drosophila melanogaster.	I Schneider	J Embryol Exp Morphol	1972	4625067	Yes
2867	921	921.0	18.34	18.3	The ubiquitin-proteasome pathway: on protein death and cell life.	A Ciechanover	EMBO J	1998	9857172	No
2868	921	921.0	22.07	22.1	GLIA: listening and talking to the synapse.	P G Haydon	Nat Rev Neurosci	2001	11256079	No
2869	1842	921.0	0.0	0.0	Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran.	R R GUILLARD, J H RYTHER	Can J Microbiol	1962	13902807	Yes
2870	5524	920.7	154.46	25.7	An obesity-associated gut microbiome with increased capacity for energy harvest.	Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I Gordon	Nature	2006	17183312	Yes
2871	1839	919.5	0.0	0.0	A rapid, sensitive, and specific method for the determination of protein in dilute solution.	W Schaffner, C Weissmann	Anal Biochem	1973	4128882	Yes
2872	1839	919.5	68.44	34.2	Stochastic relaxation, gibbs distributions, and the bayesian restoration of images.	S Geman, D Geman	IEEE Trans Pattern Anal Mach Intell	1984	22499653	Yes
2873	919	919.0	41.19	41.2	A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes.	S T Tiffany	Psychol Rev	1990	2186423	No
2874	919	919.0	0.0	0.0	Structure and function of intercellular junctions.	L A Staehelin	Int Rev Cytol	1974	4611943	No
2875	2757	919.0	90.66	30.2	A sensitive and reliable locomotor rating scale for open field testing in rats.	D M Basso, M S Beattie, J C Bresnahan	J Neurotrauma	1995	7783230	Yes
2876	919	919.0	20.38	20.4	Fibrotic disease and the T(H)1/T(H)2 paradigm.	Thomas A Wynn	Nat Rev Immunol	2004	15286725	No
2877	5511	918.5	234.39	39.1	The occurrence of sleep-disordered breathing among middle-aged adults.	T Young, M Palta, J Dempsey, J Skatrud, S Weber, S Badr	N Engl J Med	1993	8464434	Yes
2878	5509	918.2	197.68	32.9	Prevalence of overweight and obesity in the United States, 1999-2004.	Cynthia L Ogden, Margaret D Carroll, Lester R Curtin, Margaret A McDowell, Carolyn J Tabak, Katherine M Flegal	JAMA	2006	16595758	Yes
2879	918	918.0	19.37	19.4	Telomeres and human disease: ageing, cancer and beyond.	Maria A Blasco	Nat Rev Genet	2005	16136653	No
2880	918	918.0	39.46	39.5	Physiological implications of hydrogen sulfide: a whiff exploration that blossomed.	Rui Wang	Physiol Rev	2012	22535897	No
2881	1835	917.5	59.2	29.6	Ageing and Parkinson's disease: substantia nigra regional selectivity.	J M Fearnley, A J Lees	Brain	1991	1933245	Yes
2882	1835	917.5	63.25	31.6	Strategies in the design of nanoparticles for therapeutic applications.	Robby A Petros, Joseph M DeSimone	Nat Rev Drug Discov	2010	20616808	No
2883	2750	916.7	90.12	30.0	Spirometric reference values from a sample of the general U.S. population.	J L Hankinson, J R Odencrantz, K B Fedan	Am J Respir Crit Care Med	1999	9872837	Yes
2884	1833	916.5	43.2	21.6	Roles of CHOP/GADD153 in endoplasmic reticulum stress.	S Oyadomari, M Mori	Cell Death Differ	2004	14685163	No
2885	1833	916.5	102.95	51.5	3D bioprinting of tissues and organs.	Sean V Murphy, Anthony Atala	Nat Biotechnol	2014	25093879	Yes
2886	916	916.0	33.9	33.9	The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.	R G Gerrity	Am J Pathol	1981	7234961	Yes
2887	1832	916.0	54.06	27.0	Protein oxidation in aging, disease, and oxidative stress.	B S Berlett, E R Stadtman	J Biol Chem	1997	9252331	No
2888	916	916.0	29.42	29.4	Limbic-cortical dysregulation: a proposed model of depression.	H S Mayberg	J Neuropsychiatry Clin Neurosci	1997	9276848	No
2889	1832	916.0	49.13	24.6	Hepatitis C virus infection.	G M Lauer, B D Walker	N Engl J Med	2001	11439948	No
2890	1830	915.0	69.6	34.8	Population growth makes waves in the distribution of pairwise genetic differences.	A R Rogers, H Harpending	Mol Biol Evol	1992	1316531	Yes
2891	915	915.0	25.14	25.1	Life, death, and the pursuit of apoptosis.	E White	Genes Dev	1996	8557188	No
2892	915	915.0	31.98	32.0	Reducing children's television viewing to prevent obesity: a randomized controlled trial.	T N Robinson	JAMA	1999	10546696	Yes
2893	915	915.0	23.43	23.4	The prefrontal cortex--an update: time is of the essence.	J M Fuster	Neuron	2001	11394996	No
2894	915	915.0	0.0	0.0	Relative and absolute strength of response as a function of frequency of reinforcement.	R J HERRNSTEIN	J Exp Anal Behav	1961	13713775	Yes
2895	914	914.0	22.56	22.6	BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data.	O Gascuel	Mol Biol Evol	1997	9254330	Yes
2896	1828	914.0	37.7	18.9	Wnt signaling: a common theme in animal development.	K M Cadigan, R Nusse	Genes Dev	1997	9407023	No
2897	914	914.0	0.0	0.0	The anterior approach for removal of ruptured cervical disks.	R B CLOWARD	J Neurosurg	1958	13599052	Yes
2898	914	914.0	22.84	22.8	Nonaqueous liquid electrolytes for lithium-based rechargeable batteries.	Kang Xu	Chem Rev	2004	15669157	Yes
2899	1828	914.0	43.33	21.7	Deep tissue two-photon microscopy.	Fritjof Helmchen, Winfried Denk	Nat Methods	2005	16299478	No
2900	914	914.0	41.62	41.6	The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles.	Eleonore Fröhlich	Int J Nanomedicine	2012	23144561	No
2901	914	914.0	45.68	45.7	Exploring Structure-Activity Data Using the Landscape Paradigm.	Rajarshi Guha	Wiley Interdiscip Rev Comput Mol Sci	2012	24163705	Yes
2902	1827	913.5	29.53	14.8	Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis.	T Lee, L Luo	Neuron	1999	10197526	Yes
2903	913	913.0	56.8	56.8	The clinical application of the biopsychosocial model.	G L Engel	Am J Psychiatry	1980	7369396	Yes
2904	913	913.0	22.9	22.9	PHD: predicting one-dimensional protein structure by profile-based neural networks.	B Rost	Methods Enzymol	1996	8743704	Yes
2905	1826	913.0	44.73	22.4	Long-term potentiation--a decade of progress?	R C Malenka, R A Nicoll	Science	1999	10489359	No
2906	913	913.0	25.48	25.5	Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis.	Peter Fransson	Hum Brain Mapp	2005	15852468	Yes
2907	1825	912.5	43.96	22.0	Mitogen-activated protein kinase pathways.	M J Robinson, M H Cobb	Curr Opin Cell Biol	1997	9069255	No
2908	912	912.0	42.04	42.0	Transduction of psychosocial stress into the neurobiology of recurrent affective disorder.	R M Post	Am J Psychiatry	1992	1353322	No
2909	912	912.0	30.74	30.7	Insecticide-treated bed nets and curtains for preventing malaria.	C Lengeler	Cochrane Database Syst Rev	2004	15106149	No
2910	912	912.0	17.22	17.2	TNF/TNFR family members in costimulation of T cell responses.	Tania H Watts	Annu Rev Immunol	2005	15771565	No
2911	912	912.0	21.85	21.9	Hypoxia, HIF1 and glucose metabolism in the solid tumour.	Nicholas C Denko	Nat Rev Cancer	2008	19143055	No
2912	911	911.0	19.38	19.4	Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.	A S Baldwin	J Clin Invest	2001	11160144	No
2913	9108	910.8	233.63	23.4	Scalable molecular dynamics with NAMD.	James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kalé, Klaus Schulten	J Comput Chem	2005	16222654	Yes
2914	1821	910.5	43.5	21.8	microRNA functions.	Natascha Bushati, Stephen M Cohen	Annu Rev Cell Dev Biol	2007	17506695	No
2915	1821	910.5	69.29	34.6	Origins and evolution of antibiotic resistance.	Julian Davies, Dorothy Davies	Microbiol Mol Biol Rev	2010	20805405	No
2916	910	910.0	23.12	23.1	ALSCRIPT: a tool to format multiple sequence alignments.	G J Barton	Protein Eng	1993	8433969	Yes
2917	910	910.0	17.64	17.6	NFAT proteins: key regulators of T-cell development and function.	Fernando Macian	Nat Rev Immunol	2005	15928679	No
2918	2730	910.0	65.07	21.7	Generation of germline-competent induced pluripotent stem cells.	Keisuke Okita, Tomoko Ichisaka, Shinya Yamanaka	Nature	2007	17554338	Yes
2919	1819	909.5	49.53	24.8	Prediction of protein secondary structure at better than 70% accuracy.	B Rost, C Sander	J Mol Biol	1993	8345525	Yes
2920	1819	909.5	0.0	0.0	Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies.	H A EDMONDSON, P E STEINER	Cancer	1954	13160935	Yes
2921	909	909.0	25.48	25.5	Chemistry and biology of the immunophilins and their immunosuppressive ligands.	S L Schreiber	Science	1991	1702904	No
2922	909	909.0	19.18	19.2	Initiation of translation in prokaryotes and eukaryotes.	M Kozak	Gene	1999	10395892	No
2923	909	909.0	23.98	24.0	Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes.	J Denis McGarry	Diabetes	2002	11756317	No
2924	909	909.0	22.74	22.7	New ideas about atrial fibrillation 50 years on.	Stanley Nattel	Nature	2002	11805846	No
2925	909	909.0	37.18	37.2	How stigma interferes with mental health care.	Patrick Corrigan	Am Psychol	2004	15491256	Yes
2926	909	909.0	31.53	31.5	G(ST) and its relatives do not measure differentiation.	Lou Jost	Mol Ecol	2008	19238703	Yes
2927	1817	908.5	63.39	31.7	Excitatory amino acids as a final common pathway for neurologic disorders.	S A Lipton, P A Rosenberg	N Engl J Med	1994	7905600	No
2928	908	908.0	0.0	0.0	Stimulus-secretion coupling: the concept and clues from chromaffin and other cells.	W W Douglas	Br J Pharmacol	1968	4882190	No
2929	908	908.0	0.0	0.0	Strategy and tactics in protein chemistry.	B S Hartley	Biochem J	1970	4923920	No
2930	908	908.0	0.0	0.0	6-Hydroxy-dopamine induced degeneration of central monoamine neurons.	U Ungerstedt	Eur J Pharmacol	1968	5718510	Yes
2931	908	908.0	33.06	33.1	Spatially heterogeneous dynamics in supercooled liquids.	M D Ediger	Annu Rev Phys Chem	2000	11031277	Yes
2932	908	908.0	27.62	27.6	The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices.	R A Jain	Biomaterials	2000	11055295	No
2933	908	908.0	30.24	30.2	Riddle of biofilm resistance.	K Lewis	Antimicrob Agents Chemother	2001	11257008	No
2934	908	908.0	0.0	0.0	The relation of the trail making test to organic brain damage.	R M REITAN	J Consult Psychol	1955	13263471	Yes
2935	908	908.0	0.0	0.0	The generalisation of student's problems when several different population variances are involved.	B L WELCH	Biometrika	1947	20287819	Yes
2936	1814	907.0	41.01	20.5	Homeobox genes and axial patterning.	W McGinnis, R Krumlauf	Cell	1992	1346368	No
2937	907	907.0	62.55	62.5	Rating scales to assess depression in school-aged children.	M Kovacs	Acta Paedopsychiatr	1981	7025571	Yes
2938	907	907.0	17.94	17.9	Chronic myeloid leukemia.	C L Sawyers	N Engl J Med	1999	10219069	No
2939	907	907.0	24.81	24.8	Nitric oxide, oxidants, and protein tyrosine nitration.	Rafael Radi	Proc Natl Acad Sci U S A	2004	15020765	Yes
2940	907	907.0	26.7	26.7	TNF-mediated inflammatory disease.	J R Bradley	J Pathol	2008	18161752	No
2941	4530	906.0	183.18	36.6	Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.	J S Beckman, T W Beckman, J Chen, P A Marshall, B A Freeman	Proc Natl Acad Sci U S A	1990	2154753	Yes
2942	906	906.0	40.46	40.5	Spatial localization in NMR spectroscopy in vivo.	P A Bottomley	Ann N Y Acad Sci	1987	3326459	No
2943	906	906.0	24.27	24.3	Solid-state nanopores.	Cees Dekker	Nat Nanotechnol	2007	18654264	No
2944	906	906.0	0.0	0.0	A simple objective technique for measuring flexibility in thinking.	E A BERG	J Gen Psychol	1948	18889466	Yes
2945	3622	905.5	100.27	25.1	The epidemiology of sepsis in the United States from 1979 through 2000.	Greg S Martin, David M Mannino, Stephanie Eaton, Marc Moss	N Engl J Med	2003	12700374	Yes
2946	5432	905.3	163.2	27.2	Prediction of coronary heart disease using risk factor categories.	P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B Kannel	Circulation	1998	9603539	Yes
2947	905	905.0	0.0	0.0	Avidin.	N M Green	Adv Protein Chem	1975	237414	Yes
2948	905	905.0	26.74	26.7	The Trk family of neurotrophin receptors.	M Barbacid	J Neurobiol	1994	7852993	No
2949	905	905.0	0.0	0.0	Antigen-antibody reactions in gels.	O OUCHTERLONY	Acta Pathol Microbiol Scand	1949	18143039	Yes
2950	1810	905.0	79.74	39.9	Catalytic dehydrogenative cross-coupling: forming carbon-carbon bonds by oxidizing two carbon-hydrogen bonds.	Charles S Yeung, Vy M Dong	Chem Rev	2011	21391561	Yes
2951	904	904.0	56.83	56.8	A "rationalized" arcsine transform.	G A Studebaker	J Speech Hear Res	1985	4046587	Yes
2952	904	904.0	0.0	0.0	Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion.	P O Seglen	Exp Cell Res	1973	4358115	Yes
2953	904	904.0	38.79	38.8	The phenomenon of the acute phase response.	I Kushner	Ann N Y Acad Sci	1982	7046585	No
2954	1808	904.0	46.98	23.5	Regulation of wound healing by growth factors and cytokines.	Sabine Werner, Richard Grose	Physiol Rev	2003	12843410	No
2955	904	904.0	0.0	0.0	Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig.	G D WINTER	Nature	1962	14007593	Yes
2956	1808	904.0	51.37	25.7	Epidemiology of Parkinson's disease.	Lonneke M L de Lau, Monique M B Breteler	Lancet Neurol	2006	16713924	No
2957	904	904.0	22.71	22.7	A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage.	Lawrence Steinman	Nat Med	2007	17290272	No
2958	3615	903.8	103.33	25.8	MEGA2: molecular evolutionary genetics analysis software.	S Kumar, K Tamura, I B Jakobsen, M Nei	Bioinformatics	2001	11751241	Yes
2959	1807	903.5	86.08	43.0	Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal.	H Esterbauer, K H Cheeseman	Methods Enzymol	1990	2233308	Yes
2960	1807	903.5	64.74	32.4	Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.	J L Weber, P E May	Am J Hum Genet	1989	2916582	Yes
2961	2710	903.3	68.99	23.0	Photodynamic therapy for cancer.	Dennis E J G J Dolmans, Dai Fukumura, Rakesh K Jain	Nat Rev Cancer	2003	12724736	No
2962	1806	903.0	52.87	26.4	The protective effects of estrogen on the cardiovascular system.	M E Mendelsohn, R H Karas	N Engl J Med	1999	10362825	No
2963	903	903.0	23.93	23.9	Current concepts of the pathogenesis of the acute coronary syndromes.	P Libby	Circulation	2001	11457759	No
2964	903	903.0	23.86	23.9	Seed Germination and Dormancy.	J. D. Bewley	Plant Cell	1997	12237375	Yes
2965	903	903.0	23.45	23.4	Principles and challenges of genomewide DNA methylation analysis.	Peter W Laird	Nat Rev Genet	2010	20125086	No
2966	903	903.0	34.13	34.1	Apoptosis in cancer: from pathogenesis to treatment.	Rebecca S Y Wong	J Exp Clin Cancer Res	2011	21943236	No
2967	8126	902.9	250.45	27.8	MolProbity: all-atom structure validation for macromolecular crystallography.	Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C Richardson	Acta Crystallogr D Biol Crystallogr	2010	20057044	Yes
2968	902	902.0	115.48	115.5	The analysis of errors in orthodontic measurements.	W J Houston	Am J Orthod	1983	6573846	Yes
2969	1804	902.0	94.06	47.0	Rapid procedure for detection and isolation of large and small plasmids.	C I Kado, S T Liu	J Bacteriol	1981	7009583	Yes
2970	1804	902.0	38.63	19.3	Cellular functions regulated by Src family kinases.	S M Thomas, J S Brugge	Annu Rev Cell Dev Biol	1997	9442882	No
2971	1804	902.0	63.32	31.7	Physiological time-series analysis using approximate entropy and sample entropy.	J S Richman, J R Moorman	Am J Physiol Heart Circ Physiol	2000	10843903	Yes
2972	902	902.0	49.37	49.4	The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults.	L S Radloff	J Youth Adolesc	1991	24265004	Yes
2973	901	901.0	67.75	67.8	Calcium phosphate ceramics as hard tissue prosthetics.	M Jarcho	Clin Orthop Relat Res	1981	7018783	No
2974	1802	901.0	37.23	18.6	CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production.	A M Thornton, E M Shevach	J Exp Med	1998	9670041	Yes
2975	901	901.0	39.36	39.4	A review of psychological risk factors in back and neck pain.	S J Linton	Spine (Phila Pa 1976)	2000	10788861	No
2976	1802	901.0	51.53	25.8	Hydrogels for tissue engineering.	K Y Lee, D J Mooney	Chem Rev	2001	11710233	No
2977	3604	901.0	112.78	28.2	Measurement of the elastic properties and intrinsic strength of monolayer graphene.	Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James Hone	Science	2008	18635798	Yes
2978	1802	901.0	66.86	33.4	DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI.	Yan Chao-Gan, Zang Yu-Feng	Front Syst Neurosci	2010	20577591	Yes
2979	901	901.0	43.39	43.4	A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading.	Cathy J Price	Neuroimage	2012	22584224	No
2980	900	900.0	25.43	25.4	Tumor suppressor genes.	R A Weinberg	Science	1991	1659741	No
2981	900	900.0	27.98	28.0	Akaike's information criterion in generalized estimating equations.	W Pan	Biometrics	2001	11252586	Yes
2982	2698	899.3	88.4	29.5	Regulation of cancer cell metabolism.	Rob A Cairns, Isaac S Harris, Tak W Mak	Nat Rev Cancer	2011	21258394	No
2983	1798	899.0	0.0	0.0	Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme.	A Warshel, M Levitt	J Mol Biol	1976	985660	Yes
2984	899	899.0	29.26	29.3	Pharmacology of cannabinoid CB1 and CB2 receptors.	R G Pertwee	Pharmacol Ther	1997	9336020	No
2985	899	899.0	21.75	21.8	Epstein-Barr virus infection.	J I Cohen	N Engl J Med	2000	10944566	No
2986	899	899.0	16.8	16.8	The anaphase promoting complex/cyclosome: a machine designed to destroy.	Jan-Michael Peters	Nat Rev Mol Cell Biol	2006	16896351	No
2987	899	899.0	24.36	24.4	Transcriptional paradigms in mammalian mitochondrial biogenesis and function.	Richard C Scarpulla	Physiol Rev	2008	18391175	No
2988	898	898.0	31.6	31.6	Animal mitochondrial DNA: structure and evolution.	D R Wolstenholme	Int Rev Cytol	1992	1452431	No
2989	898	898.0	54.45	54.5	Analysis of Fickian and non-Fickian drug release from polymers.	N A Peppas	Pharm Acta Helv	1985	4011621	Yes
2990	898	898.0	26.0	26.0	Electrochemiluminescence (ECL).	Mark M Richter	Chem Rev	2004	15186186	No
2991	1796	898.0	56.34	28.2	BODIPY dyes and their derivatives: syntheses and spectroscopic properties.	Aurore Loudet, Kevin Burgess	Chem Rev	2007	17924696	Yes
2992	898	898.0	28.95	28.9	Species concepts and species delimitation.	Kevin De Queiroz	Syst Biol	2007	18027281	Yes
2993	5387	897.8	157.57	26.3	The capsaicin receptor: a heat-activated ion channel in the pain pathway.	M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D Julius	Nature	1997	9349813	Yes
2994	3590	897.5	102.18	25.5	Universal sample preparation method for proteome analysis.	Jacek R Wiśniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias Mann	Nat Methods	2009	19377485	Yes
2995	897	897.0	42.78	42.8	Geriatric Depression Scale.	J A Yesavage	Psychopharmacol Bull	1988	3249773	Yes
2996	1794	897.0	45.73	22.9	A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli.	C S Hoffman, F Winston	Gene	1987	3319781	Yes
2997	897	897.0	23.24	23.2	SETOR: hardware-lighted three-dimensional solid model representations of macromolecules.	S V Evans	J Mol Graph	1993	8347566	Yes
2998	897	897.0	39.92	39.9	Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants.	R W Bohannon	Age Ageing	1997	9143432	Yes
2999	897	897.0	0.0	0.0	The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera.	S V BOYDEN	J Exp Med	1951	14803635	Yes
3000	1794	897.0	66.24	33.1	The reward circuit: linking primate anatomy and human imaging.	Suzanne N Haber, Brian Knutson	Neuropsychopharmacology	2010	19812543	No
3001	4483	896.6	145.35	29.1	Quantitative assessment of tactile allodynia in the rat paw.	S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L Yaksh	J Neurosci Methods	1994	7990513	Yes
3002	2688	896.0	0.0	0.0	Depression: a new animal model sensitive to antidepressant treatments.	R D Porsolt, M Le Pichon, M Jalfre	Nature	1977	559941	Yes
3003	1792	896.0	36.62	18.3	AP-1 as a regulator of cell life and death.	Eitan Shaulian, Michael Karin	Nat Cell Biol	2002	11988758	No
3004	896	896.0	21.55	21.6	The tumor microenvironment and its role in promoting tumor growth.	T L Whiteside	Oncogene	2008	18836471	No
3005	896	896.0	28.26	28.3	AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function.	D Grahame Hardie	Genes Dev	2011	21937710	No
3006	2687	895.7	94.78	31.6	Health benefits of physical activity: the evidence.	Darren E R Warburton, Crystal Whitney Nicol, Shannon S D Bredin	CMAJ	2006	16534088	No
3007	1791	895.5	71.57	35.8	Role of oxidized low density lipoprotein in atherogenesis.	J L Witztum, D Steinberg	J Clin Invest	1991	1752940	No
3008	1791	895.5	0.0	0.0	A protein sequenator.	P Edman, G Begg	Eur J Biochem	1967	6059350	Yes
3009	1791	895.5	77.2	38.6	Pharmaceuticals and personal care products in the environment: agents of subtle change?	C G Daughton, T A Ternes	Environ Health Perspect	1999	10592150	No
3010	1791	895.5	52.73	26.4	Humans integrate visual and haptic information in a statistically optimal fashion.	Marc O Ernst, Martin S Banks	Nature	2002	11807554	Yes
3011	2686	895.3	121.19	40.4	Neighborhoods and violent crime: a multilevel study of collective efficacy.	R J Sampson, S W Raudenbush, F Earls	Science	1997	9252316	Yes
3012	895	895.0	29.05	29.1	Presynaptic nicotinic ACh receptors.	S Wonnacott	Trends Neurosci	1997	9023878	No
3013	895	895.0	29.36	29.4	On the utility of P3 amplitude as a measure of processing capacity.	A Kok	Psychophysiology	2001	11352145	No
3014	895	895.0	23.21	23.2	Natural history of chronic hepatitis C.	Leonard B Seeff	Hepatology	2002	12407575	No
3015	8052	894.7	233.36	25.9	Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation.	Cole Trapnell, Brian A Williams, Geo Pertea, Ali Mortazavi, Gordon Kwan, Marijke J van Baren, Steven L Salzberg, Barbara J Wold, Lior Pachter	Nat Biotechnol	2010	20436464	Yes
3016	1789	894.5	32.99	16.5	Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain.	W Gu, R G Roeder	Cell	1997	9288740	Yes
3017	1789	894.5	50.73	25.4	An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance.	Gary Aston-Jones, Jonathan D Cohen	Annu Rev Neurosci	2005	16022602	No
3018	5366	894.3	128.97	21.5	Obesity is associated with macrophage accumulation in adipose tissue.	Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W Ferrante	J Clin Invest	2003	14679176	Yes
3019	2682	894.0	171.22	57.1	Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines.	F Guillemin, C Bombardier, D Beaton	J Clin Epidemiol	1993	8263569	No
3020	894	894.0	23.65	23.6	Aptamers: an emerging class of molecules that rival antibodies in diagnostics.	S D Jayasena	Clin Chem	1999	10471678	No
3021	1787	893.5	45.46	22.7	Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133.	G A Gonzalez, M R Montminy	Cell	1989	2573431	Yes
3022	893	893.0	0.0	0.0	Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis.	M P Blaustein	Am J Physiol	1977	324293	No
3023	1785	892.5	33.1	16.6	Effective targeted gene 'knockdown' in zebrafish.	A Nasevicius, S C Ekker	Nat Genet	2000	11017081	Yes
3024	892	892.0	25.12	25.1	A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.	J Milbrandt	Science	1987	3672127	Yes
3025	1784	892.0	0.0	0.0	Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes.	E Engvall, P Perlmann	J Immunol	1972	4113792	Yes
3026	892	892.0	23.43	23.4	Signal transduction via the MAP kinases: proceed at your own RSK.	J Blenis	Proc Natl Acad Sci U S A	1993	8392180	No
3027	892	892.0	16.74	16.7	Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.	R A Frye	Biochem Biophys Res Commun	2000	10873683	Yes
3028	1784	892.0	33.14	16.6	An extensive class of small RNAs in Caenorhabditis elegans.	R C Lee, V Ambros	Science	2001	11679672	Yes
3029	892	892.0	17.64	17.6	MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing.	Victor Ambros	Cell	2003	12809598	No
3030	892	892.0	0.0	0.0	A cytoarchitectonic atlas of the spinal cord in the cat.	B REXED	J Comp Neurol	1954	13163236	Yes
3031	892	892.0	27.28	27.3	Production and scavenging of reactive oxygen species in chloroplasts and their functions.	Kozi Asada	Plant Physiol	2006	16760493	Yes
3032	891	891.0	31.12	31.1	Qinghaosu (artemisinin): an antimalarial drug from China.	D L Klayman	Science	1985	3887571	No
3033	891	891.0	0.0	0.0	Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.	J A Miller	Cancer Res	1970	4915745	No
3034	891	891.0	32.51	32.5	Food reward: brain substrates of wanting and liking.	K C Berridge	Neurosci Biobehav Rev	1996	8622814	No
3035	891	891.0	0.0	0.0	Aerobic work capacity in men and women with special reference to age.	I ASTRAND	Acta Physiol Scand Suppl	1960	13794892	Yes
3036	891	891.0	25.3	25.3	Pathogenesis of osteoporosis: concepts, conflicts, and prospects.	Lawrence G Raisz	J Clin Invest	2005	16322775	No
3037	1781	890.5	93.34	46.7	Statistical methods in cancer research. Volume I - The analysis of case-control studies.	N E Breslow, N E Day	IARC Sci Publ	1980	7216345	Yes
3038	1781	890.5	44.58	22.3	Obesity and insulin resistance.	B B Kahn, J S Flier	J Clin Invest	2000	10953022	No
3039	1780	890.0	36.94	18.5	The druggable genome.	Andrew L Hopkins, Colin R Groom	Nat Rev Drug Discov	2002	12209152	No
3040	890	890.0	0.0	0.0	A production of amino acids under possible primitive earth conditions.	S L MILLER	Science	1953	13056598	Yes
3041	890	890.0	0.0	0.0	A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma.	D MATTINGLY	J Clin Pathol	1962	14471419	Yes
3042	890	890.0	19.04	19.0	The evolutionary significance of cis-regulatory mutations.	Gregory A Wray	Nat Rev Genet	2007	17304246	No
3043	890	890.0	23.56	23.6	Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases.	Thomas A Wynn	J Clin Invest	2007	17332879	No
3044	890	890.0	25.12	25.1	Targeting DNA topoisomerase II in cancer chemotherapy.	John L Nitiss	Nat Rev Cancer	2009	19377506	No
3045	1780	890.0	46.05	23.0	Establishing, maintaining and modifying DNA methylation patterns in plants and animals.	Julie A Law, Steven E Jacobsen	Nat Rev Genet	2010	20142834	No
3046	890	890.0	38.67	38.7	The role of senescent cells in ageing.	Jan M van Deursen	Nature	2014	24848057	No
3047	1779	889.5	75.28	37.6	Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation.	A E Czeizel, I Dudás	N Engl J Med	1992	1307234	Yes
3048	1779	889.5	51.81	25.9	Recent developments in the MAFFT multiple sequence alignment program.	Kazutaka Katoh, Hiroyuki Toh	Brief Bioinform	2008	18372315	Yes
3049	4445	889.0	168.62	33.7	Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure.	Salim Yusuf, Bertram Pitt, Clarence E Davis, William B Hood, Jay N Cohn	N Engl J Med	1991	2057034	Yes
3050	889	889.0	22.63	22.6	ECM and cell surface proteolysis: regulating cellular ecology.	Z Werb	Cell	1997	9390552	No
3051	1778	889.0	54.99	27.5	Fitness effects on the cognitive function of older adults: a meta-analytic study.	Stanley Colcombe, Arthur F Kramer	Psychol Sci	2003	12661673	Yes
3052	889	889.0	25.0	25.0	Formation and function of the myofibroblast during tissue repair.	Boris Hinz	J Invest Dermatol	2007	17299435	No
3053	889	889.0	29.53	29.5	Regulation of glutathione synthesis.	Shelly C Lu	Mol Aspects Med	2009	18601945	No
3054	888	888.0	0.0	0.0	Transformation of yeast by a replicating hybrid plasmid.	J D Beggs	Nature	1978	357984	Yes
3055	888	888.0	23.62	23.6	Amyloid, the presenilins and Alzheimer's disease.	J Hardy	Trends Neurosci	1997	9106355	No
3056	888	888.0	36.09	36.1	Predictors of postpartum depression: an update.	C T Beck	Nurs Res	2001	11570712	Yes
3057	1776	888.0	37.95	19.0	Convergence of Wnt, beta-catenin, and cadherin pathways.	W James Nelson, Roel Nusse	Science	2004	15001769	No
3058	888	888.0	0.0	0.0	The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application.	S HESTRIN	J Biol Chem	1949	18133390	Yes
3059	1776	888.0	0.0	0.0	Brain stem reticular formation and activation of the EEG.	G Moruzzi, H W Magoun	Electroencephalogr Clin Neurophysiol	1949	18421835	Yes
3060	888	888.0	81.47	81.5	Understanding Bland Altman analysis.	Davide Giavarina	Biochem Med (Zagreb)	2015	26110027	No
3061	887	887.0	27.88	27.9	Linkage strategies for genetically complex traits. I. Multilocus models.	N Risch	Am J Hum Genet	1990	2301392	Yes
3062	1774	887.0	0.0	0.0	Chronic catheterization of the spinal subarachnoid space.	T L Yaksh, T A Rudy	Physiol Behav	1976	14677603	Yes
3063	887	887.0	30.01	30.0	Atomic layer deposition: an overview.	Steven M George	Chem Rev	2010	19947596	Yes
3064	1773	886.5	0.0	0.0	High resolution acrylamide gel electrophoresis of histones.	S Panyim, R Chalkley	Arch Biochem Biophys	1969	5778650	Yes
3065	1772	886.0	0.0	0.0	Functions of lysosomes.	C De Duve, R Wattiaux	Annu Rev Physiol	1966	5322983	No
3066	886	886.0	18.43	18.4	Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins.	M D Resh	Biochim Biophys Acta	1999	10446384	No
3067	886	886.0	0.0	0.0	The cytoarchitectonic organization of the spinal cord in the cat.	B REXED	J Comp Neurol	1952	14946260	Yes
3068	1772	886.0	38.12	19.1	Of mice and not men: differences between mouse and human immunology.	Javier Mestas, Christopher C W Hughes	J Immunol	2004	14978070	No
3069	2657	885.7	56.54	18.8	Release of chromatin protein HMGB1 by necrotic cells triggers inflammation.	Paola Scaffidi, Tom Misteli, Marco E Bianchi	Nature	2002	12110890	Yes
3070	1771	885.5	0.0	0.0	A rating scale for extrapyramidal side effects.	G M Simpson, J W Angus	Acta Psychiatr Scand Suppl	1970	4917967	Yes
3071	2656	885.3	61.29	20.4	TGF-beta signalling from cell membrane to nucleus through SMAD proteins.	C H Heldin, K Miyazono, P ten Dijke	Nature	1997	9393997	No
3072	885	885.0	21.96	22.0	Molecular mechanisms of myocardial remodeling.	B Swynghedauw	Physiol Rev	1999	9922372	No
3073	1770	885.0	57.26	28.6	A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions.	Yan Zhao, Donald G Truhlar	J Chem Phys	2006	17129083	Yes
3074	885	885.0	34.48	34.5	Lanthanide luminescence for biomedical analyses and imaging.	Jean-Claude G Bünzli	Chem Rev	2010	20151630	No
3075	2653	884.3	76.9	25.6	Use and abuse of HOMA modeling.	Tara M Wallace, Jonathan C Levy, David R Matthews	Diabetes Care	2004	15161807	No
3076	2653	884.3	76.17	25.4	The widespread regulation of microRNA biogenesis, function and decay.	Jacek Krol, Inga Loedige, Witold Filipowicz	Nat Rev Genet	2010	20661255	No
3077	884	884.0	0.0	0.0	Fundamental patterns of knowing in nursing.	B Carper	ANS Adv Nurs Sci	1978	110216	Yes
3078	884	884.0	28.47	28.5	Aging, energy, and oxidative stress in neurodegenerative diseases.	M F Beal	Ann Neurol	1995	7668820	No
3079	884	884.0	19.04	19.0	Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution.	Mats G L Gustafsson	Proc Natl Acad Sci U S A	2005	16141335	Yes
3080	884	884.0	50.67	50.7	A comprehensive review on metabolic syndrome.	Jaspinder Kaur	Cardiol Res Pract	2014	24711954	No
3081	2651	883.7	0.0	0.0	Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation.	D D SABATINI, K BENSCH, R J BARRNETT	J Cell Biol	1963	13975866	Yes
3082	2650	883.3	107.6	35.9	The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting.	C Kirschbaum, K M Pirke, D H Hellhammer	Neuropsychobiology	1993	8255414	Yes
3083	1766	883.0	0.0	0.0	Solubilization of membranes by detergents.	A Helenius, K Simons	Biochim Biophys Acta	1975	1091302	No
3084	883	883.0	32.07	32.1	Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections.	F Hefti	J Neurosci	1986	3746405	Yes
3085	883	883.0	29.51	29.5	Ion suppression in mass spectrometry.	Thomas M Annesley	Clin Chem	2003	12816898	No
3086	883	883.0	29.27	29.3	Targeting recovery: priorities of the spinal cord-injured population.	Kim D Anderson	J Neurotrauma	2004	15672628	Yes
3087	1765	882.5	0.0	0.0	Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice.	J D McGhee, P H von Hippel	J Mol Biol	1974	4416620	Yes
3088	882	882.0	55.96	56.0	ROC methodology in radiologic imaging.	C E Metz	Invest Radiol	1986	3095258	No
3089	882	882.0	35.57	35.6	Selective attention and the organization of visual information.	J Duncan	J Exp Psychol Gen	1984	6240521	Yes
3090	882	882.0	25.55	25.6	Mode of action of membrane active antimicrobial peptides.	Yechiel Shai	Biopolymers	2002	12491537	No
3091	882	882.0	21.43	21.4	The state of lipid rafts: from model membranes to cells.	Michael Edidin	Annu Rev Biophys Biomol Struct	2003	12543707	No
3092	1764	882.0	49.75	24.9	Adipocytokines: mediators linking adipose tissue, inflammation and immunity.	Herbert Tilg, Alexander R Moschen	Nat Rev Immunol	2006	16998510	No
3093	1763	881.5	0.0	0.0	Immunoassay of insulin with insulin-antibody precipitate.	C N HALES, P J RANDLE	Biochem J	1963	13952078	Yes
3094	1763	881.5	0.0	0.0	A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines.	A H ANTON, D F SAYRE	J Pharmacol Exp Ther	1962	14013351	Yes
3095	1762	881.0	47.81	23.9	Quorum sensing: cell-to-cell communication in bacteria.	Christopher M Waters, Bonnie L Bassler	Annu Rev Cell Dev Biol	2005	16212498	No
3096	881	881.0	19.37	19.4	Models, mechanisms and clinical evidence for cancer dormancy.	Julio A Aguirre-Ghiso	Nat Rev Cancer	2007	17957189	No
3097	1761	880.5	38.08	19.0	A survey of telomerase activity in human cancer.	J W Shay, S Bacchetti	Eur J Cancer	1997	9282118	No
3098	4402	880.4	130.51	26.1	Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.	T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L Coffman	J Immunol	1986	2419430	Yes
3099	1760	880.0	40.83	20.4	InterProScan--an integration platform for the signature-recognition methods in InterPro.	E M Zdobnov, R Apweiler	Bioinformatics	2001	11590104	Yes
3100	880	880.0	34.48	34.5	Sensorimotor integration in human postural control.	R J Peterka	J Neurophysiol	2002	12205132	Yes
3101	880	880.0	22.0	22.0	Serine protease mechanism and specificity.	Lizbeth Hedstrom	Chem Rev	2002	12475199	No
3102	880	880.0	21.51	21.5	r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock.	Michael J Sanderson	Bioinformatics	2003	12538260	Yes
3103	880	880.0	26.24	26.2	N-heterocyclic carbenes: a new concept in organometallic catalysis.	Wolfgang A Herrmann	Angew Chem Int Ed Engl	2002	19750753	Yes
3104	879	879.0	0.0	0.0	Renin-angiotensin system: biochemistry and mechanisms of action.	M J Peach	Physiol Rev	1977	191856	No
3105	1758	879.0	36.95	18.5	Rho GTPases and signaling networks.	L Van Aelst, C D'Souza-Schorey	Genes Dev	1997	9308960	No
3106	879	879.0	21.98	22.0	A cortical-hippocampal system for declarative memory.	H Eichenbaum	Nat Rev Neurosci	2000	11252767	No
3107	879	879.0	21.92	21.9	A likelihood approach to estimating phylogeny from discrete morphological character data.	P O Lewis	Syst Biol	2001	12116640	Yes
3108	879	879.0	24.05	24.1	Context, ambiguity, and unlearning: sources of relapse after behavioral extinction.	Mark E Bouton	Biol Psychiatry	2002	12437938	No
3109	879	879.0	15.27	15.3	T cell anergy.	Ronald H Schwartz	Annu Rev Immunol	2003	12471050	No
3110	879	879.0	22.12	22.1	Viruses in the sea.	Curtis A Suttle	Nature	2005	16163346	No
3111	1756	878.0	42.78	21.4	Multiple nuclear factors interact with the immunoglobulin enhancer sequences.	R Sen, D Baltimore	Cell	1986	3091258	Yes
3112	878	878.0	25.42	25.4	Neuropathology of Parkinson's disease.	L S Forno	J Neuropathol Exp Neurol	1996	8786384	No
3113	878	878.0	15.34	15.3	SCF and Cullin/Ring H2-based ubiquitin ligases.	R J Deshaies	Annu Rev Cell Dev Biol	1999	10611969	No
3114	878	878.0	0.0	0.0	Nutrition needs of mammalian cells in tissue culture.	H EAGLE	Science	1955	13255879	Yes
3115	2633	877.7	135.92	45.3	Measurement of health status. Ascertaining the minimal clinically important difference.	R Jaeschke, J Singer, G H Guyatt	Control Clin Trials	1989	2691207	Yes
3116	3510	877.5	96.59	24.1	Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter.	L M Guzman, D Belin, M J Carson, J Beckwith	J Bacteriol	1995	7608087	Yes
3117	877	877.0	31.88	31.9	Fibronectin and its receptors.	E Ruoslahti	Annu Rev Biochem	1988	2972252	No
3118	877	877.0	0.0	0.0	Displaced proximal humeral fractures. I. Classification and evaluation.	C S Neer	J Bone Joint Surg Am	1970	5455339	Yes
3119	877	877.0	19.42	19.4	[URE3] as an altered URE2 protein: evidence for a prion analog in Saccharomyces cerevisiae.	R B Wickner	Science	1994	7909170	No
3120	877	877.0	28.68	28.7	Venous thrombosis: a multicausal disease.	F R Rosendaal	Lancet	1999	10209995	No
3121	877	877.0	0.0	0.0	The diagnosis of ischaemic heart pain and intermittent claudication in field surveys.	G A ROSE	Bull World Health Organ	1962	13974778	Yes
3122	877	877.0	17.11	17.1	Dendritic-cell control of pathogen-driven T-cell polarization.	Martien L Kapsenberg	Nat Rev Immunol	2003	14647480	No
3123	1753	876.5	80.61	40.3	Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry.	A I Basbaum, H L Fields	Annu Rev Neurosci	1984	6143527	No
3124	1753	876.5	38.07	19.0	Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm.	P E Wright, H J Dyson	J Mol Biol	1999	10550212	No
3125	1753	876.5	86.75	43.4	Liposomal drug delivery systems: from concept to clinical applications.	Theresa M Allen, Pieter R Cullis	Adv Drug Deliv Rev	2013	23036225	No
3126	876	876.0	31.01	31.0	Cytochrome oxidase: an endogenous metabolic marker for neuronal activity.	M T Wong-Riley	Trends Neurosci	1989	2469224	No
3127	876	876.0	32.76	32.8	Low-molecular-weight heparins.	J I Weitz	N Engl J Med	1997	9278467	No
3128	2628	876.0	53.65	17.9	Exosomes: composition, biogenesis and function.	Clotilde Théry, Laurence Zitvogel, Sebastian Amigorena	Nat Rev Immunol	2002	12154376	No
3129	876	876.0	15.83	15.8	Roles of the NKG2D immunoreceptor and its ligands.	David H Raulet	Nat Rev Immunol	2003	14523385	No
3130	876	876.0	21.89	21.9	The neurobiology of consolidations, or, how stable is the engram?	Yadin Dudai	Annu Rev Psychol	2004	14744210	No
3131	1752	876.0	39.86	19.9	Protein aggregation and neurodegenerative disease.	Christopher A Ross, Michelle A Poirier	Nat Med	2004	15272267	No
3132	876	876.0	33.11	33.1	Clinical practice. Endometriosis.	Linda C Giudice	N Engl J Med	2010	20573927	No
3133	5251	875.2	157.93	26.3	Ghrelin is a growth-hormone-releasing acylated peptide from stomach.	M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K Kangawa	Nature	1999	10604470	Yes
3134	875	875.0	57.24	57.2	New norms of upper limb fat and muscle areas for assessment of nutritional status.	A R Frisancho	Am J Clin Nutr	1981	6975564	Yes
3135	875	875.0	24.98	25.0	Cells in stress: transcriptional activation of heat shock genes.	R I Morimoto	Science	1993	8451637	No
3136	875	875.0	0.0	0.0	ELECTRON MICROSCOPE STUDIES ON THE STRUCTURE OF NATURAL AND SYNTHETIC PROTEIN FILAMENTS FROM STRIATED MUSCLE.	H E HUXLEY	J Mol Biol	1963	14064165	Yes
3137	875	875.0	25.98	26.0	A theory of magnitude: common cortical metrics of time, space and quantity.	Vincent Walsh	Trends Cogn Sci	2003	14585444	Yes
3138	875	875.0	20.18	20.2	Sustainable hydrogen production.	John A Turner	Science	2004	15310892	Yes
3139	875	875.0	0.0	0.0	An approximate distribution of estimates of variance components.	F E SATTERTHWAITE	Biometrics	1946	20287815	Yes
3140	5245	874.2	155.08	25.8	Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients.	S Yusuf, P Sleight, J Pogue, J Bosch, R Davies, G Dagenais	N Engl J Med	2000	10639539	Yes
3141	874	874.0	33.63	33.6	Peritonectomy procedures.	P H Sugarbaker	Ann Surg	1995	7826158	Yes
3142	1748	874.0	84.37	42.2	Cronbach's alpha.	J M Bland, D G Altman	BMJ	1997	9055718	Yes
3143	1748	874.0	39.47	19.7	IAP family proteins--suppressors of apoptosis.	Q L Deveraux, J C Reed	Genes Dev	1999	9990849	No
3144	874	874.0	23.49	23.5	Quantification of beta-sheet amyloid fibril structures with thioflavin T.	H LeVine	Methods Enzymol	1999	10507030	Yes
3145	874	874.0	27.49	27.5	Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis.	Michael F Holick	Am J Clin Nutr	2004	14985208	No
3146	874	874.0	17.45	17.4	RNA regulons: coordination of post-transcriptional events.	Jack D Keene	Nat Rev Genet	2007	17572691	No
3147	874	874.0	79.16	79.2	Making sense of implementation theories, models and frameworks.	Per Nilsen	Implement Sci	2015	25895742	Yes
3148	1747	873.5	39.36	19.7	Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin.	J J Skehel, D C Wiley	Annu Rev Biochem	2000	10966468	No
3149	873	873.0	0.0	0.0	Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.	J R David	Proc Natl Acad Sci U S A	1966	5229858	Yes
3150	873	873.0	26.89	26.9	Molecular drive: a cohesive mode of species evolution.	G Dover	Nature	1982	7110332	Yes
3151	1746	873.0	63.82	31.9	Nitric oxide synthases in mammals.	R G Knowles, S Moncada	Biochem J	1994	7510950	No
3152	873	873.0	17.16	17.2	DNA methylation in cancer: too much, but also too little.	Melanie Ehrlich	Oncogene	2002	12154403	No
3153	873	873.0	19.28	19.3	Understanding the odd science of aging.	Thomas B L Kirkwood	Cell	2005	15734677	No
3154	873	873.0	22.96	23.0	Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms.	William C Aird	Circ Res	2007	17272818	No
3155	873	873.0	20.99	21.0	Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology.	Michael Forgac	Nat Rev Mol Cell Biol	2007	17912264	No
3156	2617	872.3	67.47	22.5	Obesity induces a phenotypic switch in adipose tissue macrophage polarization.	Carey N Lumeng, Jennifer L Bodzin, Alan R Saltiel	J Clin Invest	2007	17200717	Yes
3157	872	872.0	19.7	19.7	Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes.	D Hanahan	Nature	1985	2986015	Yes
3158	872	872.0	19.86	19.9	Twilight zone of protein sequence alignments.	B Rost	Protein Eng	1999	10195279	Yes
3159	872	872.0	24.73	24.7	PHOTOPROTECTION REVISITED: Genetic and Molecular Approaches.	Krishna K. Niyogi	Annu Rev Plant Physiol Plant Mol Biol	1999	15012213	Yes
3160	872	872.0	0.0	0.0	A Protection Motivation Theory of Fear Appeals and Attitude Change1.	Ronald W Rogers	J Psychol	1975	28136248	Yes
3161	3487	871.8	106.03	26.5	Real time quantitative PCR.	C A Heid, J Stevens, K J Livak, P M Williams	Genome Res	1996	8908518	Yes
3162	1743	871.5	0.0	0.0	Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells.	A Fabiato, F Fabiato	J Physiol (Paris)	1979	533865	Yes
3163	1743	871.5	56.58	28.3	The capacity of visual working memory for features and conjunctions.	S J Luck, E K Vogel	Nature	1997	9384378	Yes
3164	2614	871.3	56.14	18.7	Computer visualization of three-dimensional image data using IMOD.	J R Kremer, D N Mastronarde, J R McIntosh	J Struct Biol	1996	8742726	Yes
3165	871	871.0	46.79	46.8	How is the level of free arachidonic acid controlled in mammalian cells?	R F Irvine	Biochem J	1982	6810878	No
3166	871	871.0	34.21	34.2	Strategies of antioxidant defense.	H Sies	Eur J Biochem	1993	7688300	No
3167	871	871.0	23.14	23.1	Atherosclerosis is an inflammatory disease.	R Ross	Am Heart J	1999	10539839	No
3168	1742	871.0	54.95	27.5	Mechanisms of biofilm resistance to antimicrobial agents.	T F Mah, G A O'Toole	Trends Microbiol	2001	11166241	No
3169	871	871.0	23.41	23.4	Metagenomics: application of genomics to uncultured microorganisms.	Jo Handelsman	Microbiol Mol Biol Rev	2004	15590779	No
3170	2612	870.7	81.46	27.2	Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation.	Robert G Hart, Lesly A Pearce, Maria I Aguilar	Ann Intern Med	2007	17577005	Yes
3171	1741	870.5	37.03	18.5	AMPA receptor trafficking and synaptic plasticity.	Roberto Malinow, Robert C Malenka	Annu Rev Neurosci	2002	12052905	No
3172	2611	870.3	142.35	47.4	Scoping studies: advancing the methodology.	Danielle Levac, Heather Colquhoun, Kelly K O'Brien	Implement Sci	2010	20854677	Yes
3173	870	870.0	19.95	19.9	Cytokine receptor signalling.	J N Ihle	Nature	1995	7566171	No
3174	870	870.0	20.87	20.9	Lithium batteries and cathode materials.	M Stanley Whittingham	Chem Rev	2004	15669156	Yes
3175	1740	870.0	65.84	32.9	LigPlot+: multiple ligand-protein interaction diagrams for drug discovery.	Roman A Laskowski, Mark B Swindells	J Chem Inf Model	2011	21919503	Yes
3176	1739	869.5	73.18	36.6	Social conditions as fundamental causes of disease.	B G Link, J Phelan	J Health Soc Behav	1995	7560851	No
3177	1739	869.5	46.3	23.1	Endometriosis.	Linda C Giudice, Lee C Kao	Lancet	2004	15541453	No
3178	1739	869.5	43.96	22.0	The host defense of Drosophila melanogaster.	Bruno Lemaitre, Jules Hoffmann	Annu Rev Immunol	2007	17201680	No
3179	1739	869.5	120.27	60.1	mTOR Signaling in Growth, Metabolism, and Disease.	Robert A Saxton, David M Sabatini	Cell	2017	28283069	No
3180	869	869.0	52.55	52.5	Coping theory and research: past, present, and future.	R S Lazarus	Psychosom Med	1993	8346332	No
3181	869	869.0	36.29	36.3	Socioeconomic disadvantage and child development.	V C McLoyd	Am Psychol	1998	9491747	No
3182	869	869.0	29.53	29.5	Microbial heavy-metal resistance.	D H Nies	Appl Microbiol Biotechnol	1999	10422221	No
3183	869	869.0	20.95	20.9	The integration of macromolecular diffraction data.	Andrew G W Leslie	Acta Crystallogr D Biol Crystallogr	2006	16369093	No
3184	1737	868.5	0.0	0.0	Construct validity in psychological tests.	L J CRONBACH, P E MEEHL	Psychol Bull	1955	13245896	Yes
3185	868	868.0	67.85	67.8	A method of analysing interview transcripts in qualitative research.	P Burnard	Nurse Educ Today	1991	1775125	Yes
3186	868	868.0	43.17	43.2	A spreading-activation theory of retrieval in sentence production.	G S Dell	Psychol Rev	1986	3749399	Yes
3187	868	868.0	0.0	0.0	Evaluation of a mental test score for assessment of mental impairment in the elderly.	H M Hodkinson	Age Ageing	1972	4669880	Yes
3188	868	868.0	21.01	21.0	Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture.	H E Ruley	Nature	1983	6308473	Yes
3189	868	868.0	42.84	42.8	Gait changes in older adults: predictors of falls or indicators of fear.	B E Maki	J Am Geriatr Soc	1997	9063277	Yes
3190	3472	868.0	111.36	27.8	Biological identifications through DNA barcodes.	Paul D N Hebert, Alina Cywinska, Shelley L Ball, Jeremy R deWaard	Proc Biol Sci	2003	12614582	Yes
3191	1736	868.0	57.29	28.6	The spread of obesity in a large social network over 32 years.	Nicholas A Christakis, James H Fowler	N Engl J Med	2007	17652652	Yes
3192	868	868.0	24.54	24.5	Dengue.	Scott B Halstead	Lancet	2007	17993365	No
3193	1735	867.5	34.67	17.3	Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method.	R Daniel Gietz, Robin A Woods	Methods Enzymol	2002	12073338	Yes
3194	2602	867.3	77.24	25.7	Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints.	M K Parmar, V Torri, L Stewart	Stat Med	1998	9921604	Yes
3195	867	867.0	21.6	21.6	At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells.	M Kozak	J Mol Biol	1987	3681984	Yes
3196	867	867.0	34.13	34.1	Cholesterol and the cell membrane.	P L Yeagle	Biochim Biophys Acta	1985	3904832	No
3197	867	867.0	0.0	0.0	Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units.	C M Venkatachalam	Biopolymers	1968	5685102	Yes
3198	867	867.0	28.27	28.3	Synchronization of cortical activity and its putative role in information processing and learning.	W Singer	Annu Rev Physiol	1993	8466179	No
3199	1734	867.0	74.43	37.2	Efficacy of the Theory of Planned Behaviour: a meta-analytic review.	C J Armitage, M Conner	Br J Soc Psychol	2001	11795063	Yes
3200	1734	867.0	49.72	24.9	Mesenchymal stem cells as trophic mediators.	Arnold I Caplan, James E Dennis	J Cell Biochem	2006	16619257	No
3201	867	867.0	33.38	33.4	The World Health Report 2006: working together for health.	J-J Guilbert	Educ Health (Abingdon)	2006	17178522	Yes
3202	867	867.0	28.54	28.5	Rethinking schizophrenia.	Thomas R Insel	Nature	2010	21068826	No
3203	1733	866.5	43.94	22.0	Shape-controlled synthesis of gold and silver nanoparticles.	Yugang Sun, Younan Xia	Science	2002	12481134	Yes
3204	1733	866.5	43.49	21.7	Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis.	Daniel J Hicklin, Lee M Ellis	J Clin Oncol	2005	15585754	No
3205	1733	866.5	44.37	22.2	The Polycomb complex PRC2 and its mark in life.	Raphaël Margueron, Danny Reinberg	Nature	2011	21248841	No
3206	866	866.0	21.39	21.4	Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy.	R H Schwartz	Cell	1992	1335362	No
3207	866	866.0	35.65	35.6	Protein damage and degradation by oxygen radicals. I. general aspects.	K J Davies	J Biol Chem	1987	3036875	Yes
3208	1732	866.0	0.0	0.0	A method of trace iodination of proteins for immunologic studies.	P J McConahey, F J Dixon	Int Arch Allergy Appl Immunol	1966	4160044	Yes
3209	866	866.0	26.51	26.5	Neuronal gamma-band synchronization as a fundamental process in cortical computation.	Pascal Fries	Annu Rev Neurosci	2009	19400723	No
3210	1731	865.5	55.8	27.9	Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia.	Amit Etkin, Tor D Wager	Am J Psychiatry	2007	17898336	Yes
3211	2596	865.3	114.76	38.3	Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material.	P S Walsh, D A Metzger, R Higuchi	Biotechniques	1991	1867860	Yes
3212	865	865.0	21.6	21.6	Nucleic acid junctions and lattices.	N C Seeman	J Theor Biol	1982	6188926	Yes
3213	865	865.0	21.68	21.7	Liver regeneration.	George K Michalopoulos	J Cell Physiol	2007	17559071	No
3214	1729	864.5	37.79	18.9	Phosphoinositides in cell regulation and membrane dynamics.	Gilbert Di Paolo, Pietro De Camilli	Nature	2006	17035995	No
3215	6049	864.1	210.75	30.1	Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.	H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E Marsh	Stroke	1993	7678184	Yes
3216	864	864.0	0.0	0.0	Evolution of ageing.	T B Kirkwood	Nature	1977	593350	Yes
3217	1728	864.0	61.08	30.5	Multiple significance tests: the Bonferroni method.	J M Bland, D G Altman	BMJ	1995	7833759	Yes
3218	1728	864.0	41.2	20.6	Cell locomotion and focal adhesions are regulated by substrate flexibility.	R J Pelham, Y l Wang	Proc Natl Acad Sci U S A	1997	9391082	Yes
3219	864	864.0	27.84	27.8	Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity.	F P Guengerich	Chem Res Toxicol	2001	11409933	No
3220	864	864.0	25.85	25.9	Jasmonates: an update on biosynthesis, signal transduction and action in plant stress response, growth and development.	C Wasternack	Ann Bot	2007	17513307	No
3221	864	864.0	27.31	27.3	Principles of c-di-GMP signalling in bacteria.	Regine Hengge	Nat Rev Microbiol	2009	19287449	No
3222	863	863.0	23.23	23.2	Cadherins: a molecular family important in selective cell-cell adhesion.	M Takeichi	Annu Rev Biochem	1990	2197976	No
3223	863	863.0	24.38	24.4	Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system.	T Ikemura	J Mol Biol	1981	6175758	Yes
3224	863	863.0	35.18	35.2	Post-hoc probing of significant moderational and mediational effects in studies of pediatric populations.	Grayson N Holmbeck	J Pediatr Psychol	2002	11726683	No
3225	863	863.0	49.34	49.3	Mechanisms linking social ties and support to physical and mental health.	Peggy A Thoits	J Health Soc Behav	2011	21673143	No
3226	1725	862.5	62.69	31.3	A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR.	V L Miller, J J Mekalanos	J Bacteriol	1988	2836362	Yes
3227	862	862.0	0.0	0.0	Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method.	K Satoh	Clin Chim Acta	1978	719890	Yes
3228	862	862.0	42.61	42.6	Glutathione peroxidase.	A Wendel	Methods Enzymol	1981	7329310	Yes
3229	862	862.0	0.0	0.0	Agammaglobulinemia.	O C BRUTON	Pediatrics	1952	14929630	Yes
3230	2585	861.7	57.82	19.3	Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.	E Li, T H Bestor, R Jaenisch	Cell	1992	1606615	Yes
3231	861	861.0	33.93	33.9	Computer programs for calculating total from specified free or free from specified total ionic concentrations in aqueous solutions containing multiple metals and ligands.	A Fabiato	Methods Enzymol	1988	3231093	Yes
3232	1722	861.0	0.0	0.0	Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms.	R J Britten, D E Kohne	Science	1968	4874239	Yes
3233	860	860.0	24.51	24.5	Nidovirales: a new order comprising Coronaviridae and Arteriviridae.	D Cavanagh	Arch Virol	1997	9349308	Yes
3234	860	860.0	20.2	20.2	Fluorescence spectroscopy of single biomolecules.	S Weiss	Science	1999	10073925	No
3235	860	860.0	0.0	0.0	On the psychophysical law.	S S STEVENS	Psychol Rev	1957	13441853	Yes
3236	1720	860.0	0.0	0.0	Virus interference. I. The interferon.	A ISAACS, J LINDENMANN	Proc R Soc Lond B Biol Sci	1957	13465720	Yes
3237	1718	859.0	0.0	0.0	Calcium-dependent bacteriophage DNA infection.	M Mandel, A Higa	J Mol Biol	1970	4922220	Yes
3238	859	859.0	46.96	47.0	Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface.	E H Beachey	J Infect Dis	1981	7014727	No
3239	859	859.0	27.44	27.4	Invited review: Aging and sarcopenia.	Timothy J Doherty	J Appl Physiol (1985)	2003	12970377	No
3240	859	859.0	0.0	0.0	Filter-paper partition chromatography of sugars: 1. General description and application to the qualitative analysis of sugars in apple juice, egg white and foetal blood of sheep. with a note by R. G. Westall.	S M Partridge	Biochem J	1948	16748273	Yes
3241	1717	858.5	37.6	18.8	Autophagy in health and disease: a double-edged sword.	Takahiro Shintani, Daniel J Klionsky	Science	2004	15528435	No
3242	2575	858.3	77.21	25.7	trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses.	Salvador Capella-Gutiérrez, José M Silla-Martínez, Toni Gabaldón	Bioinformatics	2009	19505945	Yes
3243	8581	858.1	245.32	24.5	Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.	M Dominici, K Le Blanc, I Mueller, I Slaper-Cortenbach, Fc Marini, Ds Krause, Rj Deans, A Keating, Dj Prockop, Em Horwitz	Cytotherapy	2006	16923606	Yes
3244	1716	858.0	0.0	0.0	Epidermal growth factor.	G Carpenter, S Cohen	Annu Rev Biochem	1979	382984	No
3245	858	858.0	40.82	40.8	Infection by verocytotoxin-producing Escherichia coli.	M A Karmali	Clin Microbiol Rev	1989	2644022	No
3246	858	858.0	30.63	30.6	Muscarinic receptors--characterization, coupling and function.	M P Caulfield	Pharmacol Ther	1993	7504306	No
3247	858	858.0	35.09	35.1	Why we need observational studies to evaluate the effectiveness of health care.	N Black	BMJ	1996	8634569	Yes
3248	858	858.0	24.99	25.0	Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.	G Boden	Diabetes	1997	8971073	No
3249	858	858.0	17.75	17.8	Targeting death and decoy receptors of the tumour-necrosis factor superfamily.	Avi Ashkenazi	Nat Rev Cancer	2002	12189384	No
3250	858	858.0	0.0	0.0	A modified procedure for lead staining of thin sections.	G MILLONIG	J Biophys Biochem Cytol	1961	14474176	Yes
3251	3431	857.8	87.83	22.0	Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells.	E Schreiber, P Matthias, M M Müller, W Schaffner	Nucleic Acids Res	1989	2771659	Yes
3252	3429	857.2	68.07	17.0	DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.	M Okano, D W Bell, D A Haber, E Li	Cell	1999	10555141	Yes
3253	857	857.0	0.0	0.0	An approach for the treatment of penile carcinoma.	R M Cabanas	Cancer	1977	837331	Yes
3254	857	857.0	17.83	17.8	Progress in human tumour immunology and immunotherapy.	S A Rosenberg	Nature	2001	11357146	No
3255	2570	856.7	80.46	26.8	Matrix metalloproteinases: regulators of the tumor microenvironment.	Kai Kessenbrock, Vicki Plaks, Zena Werb	Cell	2010	20371345	No
3256	1713	856.5	62.4	31.2	Reactive oxygen species, cellular redox systems, and apoptosis.	Magdalena L Circu, Tak Yee Aw	Free Radic Biol Med	2010	20045723	No
3257	2569	856.3	70.49	23.5	Astrocyte-endothelial interactions at the blood-brain barrier.	N Joan Abbott, Lars Rönnbäck, Elisabeth Hansson	Nat Rev Neurosci	2006	16371949	No
3258	1712	856.0	0.0	0.0	Establishment and characterization of a human histiocytic lymphoma cell line (U-937).	C Sundström, K Nilsson	Int J Cancer	1976	178611	Yes
3259	856	856.0	43.27	43.3	Molecular aspects of ligand binding to serum albumin.	U Kragh-Hansen	Pharmacol Rev	1981	7027277	No
3260	856	856.0	25.2	25.2	Apoptosis in cancer therapy: crossing the threshold.	D E Fisher	Cell	1994	8069905	No
3261	2568	856.0	80.2	26.7	Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).	R S Spielman, R E McGinnis, W J Ewens	Am J Hum Genet	1993	8447318	Yes
3262	856	856.0	39.89	39.9	Gender variations in clinical pain experience.	A M Unruh	Pain	1996	8826503	No
3263	856	856.0	22.99	23.0	Tensegrity: the architectural basis of cellular mechanotransduction.	D E Ingber	Annu Rev Physiol	1997	9074778	No
3264	856	856.0	18.67	18.7	The Sp-family of transcription factors.	G Suske	Gene	1999	10570957	No
3265	856	856.0	23.93	23.9	The orbitofrontal cortex and reward.	E T Rolls	Cereb Cortex	2000	10731223	No
3266	856	856.0	17.27	17.3	Chemistry. How are alkynes scrambled?	Uwe H F Bunz	Science	2005	15821080	No
3267	856	856.0	26.01	26.0	Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex.	Satoshi Ikemoto	Brain Res Rev	2007	17574681	No
3268	2567	855.7	0.0	0.0	Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs.	C A WINTER, E A RISLEY, G W NUSS	Proc Soc Exp Biol Med	1962	14001233	Yes
3269	1711	855.5	0.0	0.0	Comparative aspects of the brain growth spurt.	J Dobbing, J Sands	Early Hum Dev	1979	118862	Yes
3270	855	855.0	0.0	0.0	Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities.	F Fonnum	Biochem J	1969	4982085	Yes
3271	855	855.0	17.61	17.6	The lasso method for variable selection in the Cox model.	R Tibshirani	Stat Med	1997	9044528	Yes
3272	855	855.0	29.67	29.7	The role of rumination in depressive disorders and mixed anxiety/depressive symptoms.	S Nolen-Hoeksema	J Abnorm Psychol	2000	11016119	Yes
3273	855	855.0	28.0	28.0	Neurophysiological and computational principles of cortical rhythms in cognition.	Xiao-Jing Wang	Physiol Rev	2010	20664082	No
3274	4274	854.8	177.68	35.5	DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates.	O Folmer, M Black, W Hoeh, R Lutz, R Vrijenhoek	Mol Mar Biol Biotechnol	1994	7881515	Yes
3275	1709	854.5	60.92	30.5	Compilation and analysis of Escherichia coli promoter DNA sequences.	D K Hawley, W R McClure	Nucleic Acids Res	1983	6344016	No
3276	1709	854.5	39.61	19.8	A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach.	S Whelan, N Goldman	Mol Biol Evol	2001	11319253	Yes
3277	1709	854.5	34.92	17.5	Transcriptional regulation by the phosphorylation-dependent factor CREB.	B Mayr, M Montminy	Nat Rev Mol Cell Biol	2001	11483993	No
3278	854	854.0	26.22	26.2	The emotional dog and its rational tail: a social intuitionist approach to moral judgment.	J Haidt	Psychol Rev	2001	11699120	Yes
3279	854	854.0	25.46	25.5	The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease.	David S Ludwig	JAMA	2002	11988062	No
3280	3415	853.8	102.16	25.5	A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V.	I Vermes, C Haanen, H Steffens-Nakken, C Reutelingsperger	J Immunol Methods	1995	7622868	Yes
3281	1707	853.5	41.93	21.0	Principles of protein-protein interactions.	S Jones, J M Thornton	Proc Natl Acad Sci U S A	1996	8552589	No
3282	1706	853.0	0.0	0.0	Further improvements in the plaque technique for detecting single antibody-forming cells.	A J Cunningham, A Szenberg	Immunology	1968	5653817	Yes
3283	853	853.0	28.3	28.3	Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes.	R Bonnet	Antimicrob Agents Chemother	2004	14693512	No
3284	853	853.0	22.37	22.4	The primate basal ganglia: parallel and integrative networks.	Suzanne N Haber	J Chem Neuroanat	2003	14729134	No
3285	853	853.0	23.16	23.2	Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures.	Frank Würthner	Chem Commun (Camb)	2004	15263926	Yes
3286	853	853.0	0.0	0.0	Notes on continuous stochastic phenomena.	P A P MORAN	Biometrika	1950	15420245	Yes
3287	853	853.0	39.58	39.6	U.S. Department of Agriculture and U.S. Department of Health and Human Services, Dietary Guidelines for Americans, 2010. 7th Edition, Washington, DC: U.S. Government Printing Office, January 2011.	Shelley McGuire	Adv Nutr	2011	22332062	Yes
3288	1705	852.5	0.0	0.0	The hitch-hiking effect of a favourable gene.	J M Smith, J Haigh	Genet Res	1974	4407212	Yes
3289	3410	852.5	98.47	24.6	Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.	J E Walker, M Saraste, M J Runswick, N J Gay	EMBO J	1982	6329717	Yes
3290	1705	852.5	60.45	30.2	Type 2 diabetes as an inflammatory disease.	Marc Y Donath, Steven E Shoelson	Nat Rev Immunol	2011	21233852	No
3291	852	852.0	64.53	64.5	The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement.	M M Panjabi	J Spinal Disord	1992	1490034	Yes
3292	852	852.0	32.06	32.1	Signaling through phosphatidylcholine breakdown.	J H Exton	J Biol Chem	1990	2104616	No
3293	1704	852.0	62.0	31.0	Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation.	J M Reul, E R de Kloet	Endocrinology	1985	2998738	Yes
3294	1704	852.0	39.92	20.0	p53: puzzle and paradigm.	L J Ko, C Prives	Genes Dev	1996	8654922	No
3295	2556	852.0	69.54	23.2	Nitric oxide and macrophage function.	J MacMicking, Q W Xie, C Nathan	Annu Rev Immunol	1997	9143691	No
3296	852	852.0	37.24	37.2	Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs.	A T Serajuddin	J Pharm Sci	1999	10514356	No
3297	852	852.0	27.9	27.9	The stress response to trauma and surgery.	J P Desborough	Br J Anaesth	2000	10927999	No
3298	1704	852.0	48.13	24.1	The amygdala: vigilance and emotion.	M Davis, P J Whalen	Mol Psychiatry	2001	11244481	No
3299	852	852.0	22.87	22.9	The emotional brain, fear, and the amygdala.	Joseph LeDoux	Cell Mol Neurobiol	2003	14514027	No
3300	852	852.0	26.81	26.8	What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models.	Michael A Babyak	Psychosom Med	2004	15184705	Yes
3301	1704	852.0	46.28	23.1	Toxoplasmosis.	J G Montoya, O Liesenfeld	Lancet	2004	15194258	No
3302	852	852.0	0.0	0.0	The colorimetric determination of phosphorus.	E J King	Biochem J	1932	16744823	Yes
3303	852	852.0	62.1	62.1	Abiotic Stress Signaling and Responses in Plants.	Jian-Kang Zhu	Cell	2016	27716505	No
3304	851	851.0	0.0	0.0	Human cardiovascular adjustments to exercise and thermal stress.	L B Rowell	Physiol Rev	1974	4587247	No
3305	851	851.0	36.4	36.4	Methods for dealing with reaction time outliers.	R Ratcliff	Psychol Bull	1993	8272468	Yes
3306	851	851.0	15.78	15.8	Molecular dissection of autophagy: two ubiquitin-like systems.	Y Ohsumi	Nat Rev Mol Cell Biol	2001	11265251	No
3307	851	851.0	28.15	28.1	The global burden of hepatitis C.	Daniel Lavanchy	Liver Int	2009	19207969	No
3308	851	851.0	22.79	22.8	Genomewide association studies and assessment of the risk of disease.	Teri A Manolio	N Engl J Med	2010	20647212	No
3309	850	850.0	48.84	48.8	Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs).	S Safe	Crit Rev Toxicol	1990	2124811	No
3310	850	850.0	0.0	0.0	Electrophoretic separation of plasma lipoproteins in agarose gel.	R P Noble	J Lipid Res	1968	4176473	Yes
3311	850	850.0	18.54	18.5	Validating survivin as a cancer therapeutic target.	Dario C Altieri	Nat Rev Cancer	2003	12509766	No
3312	850	850.0	18.98	19.0	The advantages and disadvantages of being polyploid.	Luca Comai	Nat Rev Genet	2005	16304599	No
3313	1700	850.0	42.66	21.3	Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.	William G Kaelin, Peter J Ratcliffe	Mol Cell	2008	18498744	No
3314	1699	849.5	79.07	39.5	Severe sepsis and septic shock.	Derek C Angus, Tom van der Poll	N Engl J Med	2013	23984731	No
3315	849	849.0	28.61	28.6	Comparing evolvability and variability of quantitative traits.	D Houle	Genetics	1992	1732160	Yes
3316	1698	849.0	71.32	35.7	Glutamate and the pathophysiology of hypoxic--ischemic brain damage.	S M Rothman, J W Olney	Ann Neurol	1986	2421636	No
3317	849	849.0	0.0	0.0	Tests for emotionality in rats and mice: a review.	J Archer	Anim Behav	1973	4578750	No
3318	1698	849.0	74.71	37.4	Excitatory amino acid transmitters.	J C Watkins, R H Evans	Annu Rev Pharmacol Toxicol	1981	6112965	No
3319	849	849.0	32.83	32.8	Properties of osteoconductive biomaterials: calcium phosphates.	Racquel Zapanta LeGeros	Clin Orthop Relat Res	2002	11937868	No
3320	849	849.0	0.0	0.0	PRELIMINARY TRIAL OF CARISOPRODOL IN MULTIPLE SCLEROSIS.	B ASHWORTH	Practitioner	1964	14143329	Yes
3321	849	849.0	18.73	18.7	Molecular signatures of natural selection.	Rasmus Nielsen	Annu Rev Genet	2005	16285858	No
3322	2546	848.7	77.76	25.9	mTOR: from growth signal integration to cancer, diabetes and ageing.	Roberto Zoncu, Alejo Efeyan, David M Sabatini	Nat Rev Mol Cell Biol	2011	21157483	No
3323	1697	848.5	75.52	37.8	The Modified Mini-Mental State (3MS) examination.	E L Teng, H C Chui	J Clin Psychiatry	1987	3611032	Yes
3324	1697	848.5	49.35	24.7	Anemia of chronic disease.	Guenter Weiss, Lawrence T Goodnough	N Engl J Med	2005	15758012	No
3325	2544	848.0	121.56	40.5	Concurrent and predictive validity of a self-reported measure of medication adherence.	D E Morisky, L W Green, D M Levine	Med Care	1986	3945130	Yes
3326	848	848.0	0.0	0.0	The moulding of senescence by natural selection.	W D Hamilton	J Theor Biol	1966	6015424	Yes
3327	1696	848.0	52.06	26.0	The evolution of cooperation.	R Axelrod, W D Hamilton	Science	1981	7466396	Yes
3328	848	848.0	24.4	24.4	Lymphokine production by human T cells in disease states.	S Romagnani	Annu Rev Immunol	1994	8011282	No
3329	848	848.0	25.76	25.8	Glutathione and its role in cellular functions.	H Sies	Free Radic Biol Med	1999	10569624	No
3330	848	848.0	17.1	17.1	Computational systems biology.	Hiroaki Kitano	Nature	2002	12432404	No
3331	848	848.0	25.9	25.9	The complex role of estrogens in inflammation.	Rainer H Straub	Endocr Rev	2007	17640948	No
3332	2542	847.3	62.56	20.9	BCL-2 family members and the mitochondria in apoptosis.	A Gross, J M McDonnell, S J Korsmeyer	Genes Dev	1999	10444588	No
3333	847	847.0	30.22	30.2	Models of speciation by sexual selection on polygenic traits.	R Lande	Proc Natl Acad Sci U S A	1981	16593036	Yes
3334	847	847.0	21.69	21.7	Rafts defined: a report on the Keystone Symposium on Lipid Rafts and Cell Function.	Linda J Pike	J Lipid Res	2006	16645198	No
3335	3388	847.0	127.78	31.9	Epidemiology and causes of preterm birth.	Robert L Goldenberg, Jennifer F Culhane, Jay D Iams, Roberto Romero	Lancet	2008	18177778	No
3336	2540	846.7	126.89	42.3	Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis.	Christopher K Prier, Danica A Rankic, David W C MacMillan	Chem Rev	2013	23509883	No
3337	2539	846.3	90.3	30.1	Validation of the Insomnia Severity Index as an outcome measure for insomnia research.	C H. Bastien, A Vallières, C M. Morin	Sleep Med	2001	11438246	Yes
3338	1692	846.0	0.0	0.0	The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid.	B N AMES, D T DUBIN	J Biol Chem	1960	13793161	Yes
3339	846	846.0	24.62	24.6	Towards a neural basis of auditory sentence processing.	Angela D Friederici	Trends Cogn Sci	2002	15866191	Yes
3340	1692	846.0	53.65	26.8	Mechanisms of mitophagy.	Richard J Youle, Derek P Narendra	Nat Rev Mol Cell Biol	2011	21179058	No
3341	3384	846.0	147.97	37.0	FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data.	Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs Schoffelen	Comput Intell Neurosci	2011	21253357	Yes
3342	846	846.0	25.69	25.7	Targeting cancer metabolism: a therapeutic window opens.	Matthew G Vander Heiden	Nat Rev Drug Discov	2011	21878982	No
3343	2537	845.7	53.42	17.8	Genetic instabilities in human cancers.	C Lengauer, K W Kinzler, B Vogelstein	Nature	1998	9872311	No
3344	1691	845.5	74.58	37.3	Understanding face recognition.	V Bruce, A Young	Br J Psychol	1986	3756376	Yes
3345	1691	845.5	29.53	14.8	Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.	Lee Zou, Stephen J Elledge	Science	2003	12791985	Yes
3346	845	845.0	24.93	24.9	The potential environmental impact of engineered nanomaterials.	Vicki L Colvin	Nat Biotechnol	2003	14520401	Yes
3347	845	845.0	15.85	15.8	Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.	Lynne E Maquat	Nat Rev Mol Cell Biol	2004	15040442	No
3348	1689	844.5	40.77	20.4	Angiogenesis as a therapeutic target.	Napoleone Ferrara, Robert S Kerbel	Nature	2005	16355214	No
3349	844	844.0	23.32	23.3	Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults.	Bei-Fan Zhou	Biomed Environ Sci	2002	12046553	Yes
3350	844	844.0	0.0	0.0	The free amino groups of insulin.	F Sanger	Biochem J	1945	16747948	Yes
3351	1688	844.0	83.38	41.7	Methods for the thematic synthesis of qualitative research in systematic reviews.	James Thomas, Angela Harden	BMC Med Res Methodol	2008	18616818	Yes
3352	844	844.0	80.23	80.2	Metazoan MicroRNAs.	David P Bartel	Cell	2018	29570994	No
3353	1687	843.5	51.46	25.7	Localized surface plasmon resonance spectroscopy and sensing.	Katherine A Willets, Richard P Van Duyne	Annu Rev Phys Chem	2007	17067281	No
3354	1686	843.0	44.83	22.4	RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression.	M B Shapiro, P Senapathy	Nucleic Acids Res	1987	3658675	Yes
3355	843	843.0	28.01	28.0	Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade.	Thomas M Tzschentke	Addict Biol	2007	17678505	No
3356	843	843.0	57.81	57.8	PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors.	Anthony L Spek	Acta Crystallogr C Struct Chem	2015	25567569	Yes
3357	1685	842.5	55.35	27.7	Cu-catalyzed azide-alkyne cycloaddition.	Morten Meldal, Christian Wenzel Tornøe	Chem Rev	2008	18698735	No
3358	842	842.0	49.96	50.0	Continuous improvement as an ideal in health care.	D M Berwick	N Engl J Med	1989	2909878	Yes
3359	842	842.0	23.28	23.3	Variation in protection by BCG: implications of and for heterologous immunity.	P E Fine	Lancet	1995	7475776	No
3360	842	842.0	47.52	47.5	Toward terminological, conceptual, and statistical clarity in the study of mediators and moderators: examples from the child-clinical and pediatric psychology literatures.	G N Holmbeck	J Consult Clin Psychol	1997	9256561	Yes
3361	842	842.0	27.77	27.8	Distracted and confused?: selective attention under load.	Nilli Lavie	Trends Cogn Sci	2005	15668100	No
3362	842	842.0	21.24	21.2	Oxygen, oxidative stress, hypoxia, and heart failure.	Frank J Giordano	J Clin Invest	2005	15765131	No
3363	842	842.0	17.47	17.5	Tetraspanin functions and associated microdomains.	Martin E Hemler	Nat Rev Mol Cell Biol	2005	16314869	No
3364	842	842.0	21.27	21.3	Angiogenesis.	Judah Folkman	Annu Rev Med	2006	16409133	No
3365	842	842.0	31.93	31.9	Social support and health: a review of physiological processes potentially underlying links to disease outcomes.	Bert N Uchino	J Behav Med	2006	16758315	No
3366	841	841.0	40.61	40.6	Omega-3 fatty acids in health and disease and in growth and development.	A P Simopoulos	Am J Clin Nutr	1991	1908631	No
3367	841	841.0	0.0	0.0	Mechanisms of lipid peroxide formation in animal tissues.	E D Wills	Biochem J	1966	5964963	Yes
3368	841	841.0	22.05	22.1	The molecular biology of leukocyte chemoattractant receptors.	P M Murphy	Annu Rev Immunol	1994	8011292	No
3369	841	841.0	20.5	20.5	Dendritic cells: unique leukocyte populations which control the primary immune response.	D N Hart	Blood	1997	9345009	No
3370	841	841.0	16.73	16.7	Ubiquitin signalling in the NF-kappaB pathway.	Zhijian J Chen	Nat Cell Biol	2005	16056267	No
3371	1682	841.0	58.5	29.2	bold: The Barcode of Life Data System (http://www.barcodinglife.org).	Sujeevan Ratnasingham, Paul D N Hebert	Mol Ecol Notes	2007	18784790	Yes
3372	841	841.0	30.96	31.0	Lanthanide-based luminescent hybrid materials.	Koen Binnemans	Chem Rev	2009	19650663	Yes
3373	1682	841.0	57.37	28.7	Metabolic reprogramming: a cancer hallmark even warburg did not anticipate.	Patrick S Ward, Craig B Thompson	Cancer Cell	2012	22439925	No
3374	2522	840.7	71.56	23.9	Ghrelin induces adiposity in rodents.	M Tschöp, D L Smiley, M L Heiman	Nature	2000	11057670	Yes
3375	5044	840.7	139.29	23.2	Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care.	D C Angus, W T Linde-Zwirble, J Lidicker, G Clermont, J Carcillo, M R Pinsky	Crit Care Med	2001	11445675	Yes
3376	2522	840.7	76.3	25.4	Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?	Dunyaporn Trachootham, Jerome Alexandre, Peng Huang	Nat Rev Drug Discov	2009	19478820	No
3377	1681	840.5	57.59	28.8	Burden of major musculoskeletal conditions.	Anthony D Woolf, Bruce Pfleger	Bull World Health Organ	2003	14710506	No

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Volume 8, April 2021