Unicorn Papers
Top ‱ cited papers from PUBMED
Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authorsCurrently, the list contains 3948 papers with ECcit ≥ 1054.0
‱ - permyriad,
, literally meaning "for (every) myriad (ten thousand)"
Volume 51, November 2024
| No. | Citations | ECcit | RCR | ECRCR | Title | Authors | Journal | Year | PMID | Article(?) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 224594 | 224594.0 | 4913.95 | 4913.9 | Cleavage of structural proteins during the assembly of the head of bacteriophage T4. | U K Laemmli | Nature | 1970 | 5432063 | Yes |
| 2 | 173656 | 173656.0 | 7034.68 | 7034.7 | A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. | M M Bradford | Anal Biochem | 1976 | 942051 | Yes |
| 3 | 286062 | 71515.5 | 0.0 | 0.0 | Protein measurement with the Folin phenol reagent. | O H Lowry, N J Rosebrough, A L Farr, R J Randall | J Biol Chem | 1951 | 14907713 | Yes |
| 4 | 123889 | 61944.5 | 3076.47 | 1538.2 | Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. | K J Livak, T D Schmittgen | Methods | 2001 | 11846609 | Yes |
| 5 | 45313 | 45313.0 | 1392.31 | 1392.3 | A short history of SHELX. | George M Sheldrick | Acta Crystallogr A | 2008 | 18156677 | Yes |
| 6 | 36907 | 36907.0 | 1189.67 | 1189.7 | Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. | T Mosmann | J Immunol Methods | 1983 | 6606682 | Yes |
| 7 | 64434 | 32217.0 | 1931.37 | 965.7 | Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. | P Chomczynski, N Sacchi | Anal Biochem | 1987 | 2440339 | Yes |
| 8 | 30234 | 30234.0 | 824.26 | 824.3 | Detection of specific sequences among DNA fragments separated by gel electrophoresis. | E M Southern | J Mol Biol | 1975 | 1195397 | Yes |
| 9 | 27980 | 27980.0 | 881.83 | 881.8 | The assessment and analysis of handedness: the Edinburgh inventory. | R C Oldfield | Neuropsychologia | 1971 | 5146491 | Yes |
| 10 | 27892 | 27892.0 | 613.62 | 613.6 | MicroRNAs: genomics, biogenesis, mechanism, and function. | David P Bartel | Cell | 2004 | 14744438 | No |
| 11 | 27230 | 27230.0 | 642.07 | 642.1 | MUSCLE: multiple sequence alignment with high accuracy and high throughput. | Robert C Edgar | Nucleic Acids Res | 2004 | 15034147 | Yes |
| 12 | 26112 | 26112.0 | 674.2 | 674.2 | A rating scale for depression. | M Hamilton | J Neurol Neurosurg Psychiatry | 1960 | 14399272 | Yes |
| 13 | 24851 | 24851.0 | 569.58 | 569.6 | A new mathematical model for relative quantification in real-time RT-PCR. | M W Pfaffl | Nucleic Acids Res | 2001 | 11328886 | Yes |
| 14 | 24502 | 24502.0 | 763.44 | 763.4 | Confidence Limits On Phylogenies: An Approach Using The Bootstrap. | Joseph Felsenstein | Evolution | 1985 | 28561359 | Yes |
| 15 | 66619 | 22206.3 | 2500.57 | 833.5 | "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. | M F Folstein, S E Folstein, P R McHugh | J Psychiatr Res | 1975 | 1202204 | Yes |
| 16 | 65999 | 21999.7 | 1651.49 | 550.5 | DNA sequencing with chain-terminating inhibitors. | F Sanger, S Nicklen, A R Coulson | Proc Natl Acad Sci U S A | 1977 | 271968 | Yes |
| 17 | 43160 | 21580.0 | 1335.49 | 667.7 | Hallmarks of cancer: the next generation. | Douglas Hanahan, Robert A Weinberg | Cell | 2011 | 21376230 | No |
| 18 | 20287 | 20287.0 | 204.7 | 204.7 | The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. | E S Reynolds | J Cell Biol | 1963 | 13986422 | Yes |
| 19 | 40419 | 20209.5 | 1247.94 | 624.0 | The neighbor-joining method: a new method for reconstructing phylogenetic trees. | N Saitou, M Nei | Mol Biol Evol | 1987 | 3447015 | Yes |
| 20 | 20097 | 20097.0 | 690.67 | 690.7 | Density-functional exchange-energy approximation with correct asymptotic behavior. | A D Becke | Phys Rev A Gen Phys | 1988 | 9900728 | Yes |
| 21 | 19612 | 19612.0 | 0.0 | 0.0 | Tissue sulfhydryl groups. | G L Ellman | Arch Biochem Biophys | 1959 | 13650640 | Yes |
| 22 | 18471 | 18471.0 | 513.76 | 513.8 | Projector augmented-wave method. | P E Blöchl | Phys Rev B Condens Matter | 1994 | 9976227 | Yes |
| 23 | 36661 | 18330.5 | 1728.14 | 864.1 | Statistical methods for assessing agreement between two methods of clinical measurement. | J M Bland, D G Altman | Lancet | 1986 | 2868172 | Yes |
| 24 | 36450 | 18225.0 | 1521.96 | 761.0 | The measurement of observer agreement for categorical data. | J R Landis, G G Koch | Biometrics | 1977 | 843571 | Yes |
| 25 | 53498 | 17832.7 | 1979.98 | 660.0 | Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. | H Towbin, T Staehelin, J Gordon | Proc Natl Acad Sci U S A | 1979 | 388439 | Yes |
| 26 | 17346 | 17346.0 | 638.53 | 638.5 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. | M Kimura | J Mol Evol | 1980 | 7463489 | Yes |
| 27 | 17341 | 17341.0 | 731.63 | 731.6 | RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. | Alexandros Stamatakis | Bioinformatics | 2014 | 24451623 | Yes |
| 28 | 16999 | 16999.0 | 426.32 | 426.3 | Atherosclerosis--an inflammatory disease. | R Ross | N Engl J Med | 1999 | 9887164 | No |
| 29 | 16751 | 16751.0 | 670.76 | 670.8 | Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. | B J Davis | Ann N Y Acad Sci | 1964 | 14240539 | Yes |
| 30 | 16631 | 16631.0 | 684.78 | 684.8 | A power primer. | J Cohen | Psychol Bull | 1992 | 19565683 | Yes |
| 31 | 32500 | 16250.0 | 0.0 | 0.0 | A rapid method of total lipid extraction and purification. | E G Bligh, W J Dyer | Can J Biochem Physiol | 1959 | 13671378 | Yes |
| 32 | 16207 | 16207.0 | 449.54 | 449.5 | High resolution two-dimensional electrophoresis of proteins. | P H O'Farrell | J Biol Chem | 1975 | 236308 | Yes |
| 33 | 31917 | 15958.5 | 1009.17 | 504.6 | Fast gapped-read alignment with Bowtie 2. | Ben Langmead, Steven L Salzberg | Nat Methods | 2012 | 22388286 | Yes |
| 34 | 15924 | 15924.0 | 0.0 | 0.0 | A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. | K Burton | Biochem J | 1956 | 13293190 | Yes |
| 35 | 47252 | 15750.7 | 1743.49 | 581.2 | Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. | Michael I Love, Wolfgang Huber, Simon Anders | Genome Biol | 2014 | 25516281 | Yes |
| 36 | 46800 | 15600.0 | 1383.2 | 461.1 | Generalized Gradient Approximation Made Simple. | J P Perdew, K Burke, M Ernzerhof | Phys Rev Lett | 1996 | 10062328 | Yes |
| 37 | 15432 | 15432.0 | 386.42 | 386.4 | MicroRNAs: target recognition and regulatory functions. | David P Bartel | Cell | 2009 | 19167326 | No |
| 38 | 30861 | 15430.5 | 778.88 | 389.4 | Fast and accurate short read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2009 | 19451168 | Yes |
| 39 | 30466 | 15233.0 | 1216.56 | 608.3 | The hospital anxiety and depression scale. | A S Zigmond, R P Snaith | Acta Psychiatr Scand | 1983 | 6880820 | Yes |
| 40 | 45461 | 15153.7 | 1297.06 | 432.4 | CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. | J D Thompson, D G Higgins, T J Gibson | Nucleic Acids Res | 1994 | 7984417 | Yes |
| 41 | 29917 | 14958.5 | 1119.04 | 559.5 | Meta-analysis in clinical trials. | R DerSimonian, N Laird | Control Clin Trials | 1986 | 3802833 | Yes |
| 42 | 14451 | 14451.0 | 563.61 | 563.6 | Catalase in vitro. | H Aebi | Methods Enzymol | 1984 | 6727660 | Yes |
| 43 | 42043 | 14014.3 | 0.0 | 0.0 | A simple method for the isolation and purification of total lipides from animal tissues. | J Folch, M Lees, G H Sloane Stanley | J Biol Chem | 1957 | 13428781 | Yes |
| 44 | 13245 | 13245.0 | 671.99 | 672.0 | Crystal structure refinement with SHELXL. | George M Sheldrick | Acta Crystallogr C Struct Chem | 2015 | 25567568 | Yes |
| 45 | 63837 | 12767.4 | 1830.57 | 366.1 | Basic local alignment search tool. | S F Altschul, W Gish, W Miller, E W Myers, D J Lipman | J Mol Biol | 1990 | 2231712 | Yes |
| 46 | 25334 | 12667.0 | 521.36 | 260.7 | Coot: model-building tools for molecular graphics. | Paul Emsley, Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2004 | 15572765 | Yes |
| 47 | 25259 | 12629.5 | 690.82 | 345.4 | Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. | G Kresse, J Furthmüller | Phys Rev B Condens Matter | 1996 | 9984901 | Yes |
| 48 | 12628 | 12628.0 | 0.0 | 0.0 | Phosphorus assay in column chromatography. | G R Bartlett | J Biol Chem | 1959 | 13641241 | Yes |
| 49 | 25079 | 12539.5 | 1026.02 | 513.0 | The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. | J E Ware, C D Sherbourne | Med Care | 1992 | 1593914 | Yes |
| 50 | 12494 | 12494.0 | 399.15 | 399.1 | Search and clustering orders of magnitude faster than BLAST. | Robert C Edgar | Bioinformatics | 2010 | 20709691 | Yes |
| 51 | 12485 | 12485.0 | 317.74 | 317.7 | Xds. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124692 | Yes |
| 52 | 12150 | 12150.0 | 562.63 | 562.6 | Self-efficacy: toward a unifying theory of behavioral change. | A Bandura | Psychol Rev | 1977 | 847061 | Yes |
| 53 | 12130 | 12130.0 | 366.73 | 366.7 | The Psychophysics Toolbox. | D H Brainard | Spat Vis | 1997 | 9176952 | Yes |
| 54 | 12070 | 12070.0 | 137.94 | 137.9 | The genetics of Caenorhabditis elegans. | S Brenner | Genetics | 1974 | 4366476 | Yes |
| 55 | 36070 | 12023.3 | 1272.91 | 424.3 | Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. | C Lee, W Yang, R G Parr | Phys Rev B Condens Matter | 1988 | 9944570 | Yes |
| 56 | 23995 | 11997.5 | 647.75 | 323.9 | Quantifying heterogeneity in a meta-analysis. | Julian P T Higgins, Simon G Thompson | Stat Med | 2002 | 12111919 | Yes |
| 57 | 23943 | 11971.5 | 521.8 | 260.9 | Processing of X-ray diffraction data collected in oscillation mode. | Z Otwinowski, W Minor | Methods Enzymol | 1997 | 27754618 | Yes |
| 58 | 11764 | 11764.0 | 386.95 | 386.9 | Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). | J F Kurtzke | Neurology | 1983 | 6685237 | Yes |
| 59 | 34786 | 11595.3 | 1349.58 | 449.9 | Trimmomatic: a flexible trimmer for Illumina sequence data. | Anthony M Bolger, Marc Lohse, Bjoern Usadel | Bioinformatics | 2014 | 24695404 | Yes |
| 60 | 11286 | 11286.0 | 450.77 | 450.8 | Investigation of the freely available easy-to-use software 'EZR' for medical statistics. | Y Kanda | Bone Marrow Transplant | 2013 | 23208313 | Yes |
| 61 | 11219 | 11219.0 | 389.04 | 389.0 | Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. | Andreas Stang | Eur J Epidemiol | 2010 | 20652370 | Yes |
| 62 | 11051 | 11051.0 | 420.64 | 420.6 | A new method for measuring daytime sleepiness: the Epworth sleepiness scale. | M W Johns | Sleep | 1991 | 1798888 | Yes |
| 63 | 21975 | 10987.5 | 838.61 | 419.3 | MAFFT multiple sequence alignment software version 7: improvements in performance and usability. | Kazutaka Katoh, Daron M Standley | Mol Biol Evol | 2013 | 23329690 | Yes |
| 64 | 21563 | 10781.5 | 558.11 | 279.1 | A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. | A P Feinberg, B Vogelstein | Anal Biochem | 1983 | 6312838 | Yes |
| 65 | 31815 | 10605.0 | 1067.95 | 356.0 | NIH Image to ImageJ: 25 years of image analysis. | Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri | Nat Methods | 2012 | 22930834 | No |
| 66 | 31783 | 10594.3 | 825.63 | 275.2 | VMD: visual molecular dynamics. | W Humphrey, A Dalke, K Schulten | J Mol Graph | 1996 | 8744570 | Yes |
| 67 | 21134 | 10567.0 | 454.55 | 227.3 | KEGG: kyoto encyclopedia of genes and genomes. | M Kanehisa, S Goto | Nucleic Acids Res | 2000 | 10592173 | Yes |
| 68 | 10535 | 10535.0 | 364.65 | 364.6 | Structure validation in chemical crystallography. | Anthony L Spek | Acta Crystallogr D Biol Crystallogr | 2009 | 19171970 | Yes |
| 69 | 21033 | 10516.5 | 460.8 | 230.4 | [20] Processing of X-ray diffraction data collected in oscillation mode. | Zbyszek Otwinowski, Wladek Minor | Methods Enzymol | 1997 | 27799103 | Yes |
| 70 | 20991 | 10495.5 | 895.54 | 447.8 | The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. | R M Baron, D A Kenny | J Pers Soc Psychol | 1986 | 3806354 | Yes |
| 71 | 41629 | 10407.2 | 1187.46 | 296.9 | Measuring inconsistency in meta-analyses. | Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman | BMJ | 2003 | 12958120 | No |
| 72 | 10294 | 10294.0 | 201.74 | 201.7 | Improvements in epoxy resin embedding methods. | J H Luft | J Biophys Biochem Cytol | 1961 | 13764136 | Yes |
| 73 | 41074 | 10268.5 | 1582.45 | 395.6 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | PLoS Med | 2009 | 19621072 | No |
| 74 | 10018 | 10018.0 | 450.39 | 450.4 | Prokka: rapid prokaryotic genome annotation. | Torsten Seemann | Bioinformatics | 2014 | 24642063 | Yes |
| 75 | 9988 | 9988.0 | 0.0 | 0.0 | On the origin of cancer cells. | O Warburg | Science | 1956 | 13298683 | Yes |
| 76 | 19799 | 9899.5 | 372.57 | 186.3 | The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. | K Weber, M Osborn | J Biol Chem | 1969 | 5806584 | Yes |
| 77 | 9710 | 9710.0 | 415.88 | 415.9 | Psychophysical bases of perceived exertion. | G A Borg | Med Sci Sports Exerc | 1982 | 7154893 | Yes |
| 78 | 9686 | 9686.0 | 272.68 | 272.7 | Evolutionary trees from DNA sequences: a maximum likelihood approach. | J Felsenstein | J Mol Evol | 1981 | 7288891 | Yes |
| 79 | 9624 | 9624.0 | 254.94 | 254.9 | Semiempirical GGA-type density functional constructed with a long-range dispersion correction. | Stefan Grimme | J Comput Chem | 2006 | 16955487 | Yes |
| 80 | 9606 | 9606.0 | 199.03 | 199.0 | Mfold web server for nucleic acid folding and hybridization prediction. | Michael Zuker | Nucleic Acids Res | 2003 | 12824337 | Yes |
| 81 | 19003 | 9501.5 | 490.79 | 245.4 | A simple method for displaying the hydropathic character of a protein. | J Kyte, R F Doolittle | J Mol Biol | 1982 | 7108955 | Yes |
| 82 | 9478 | 9478.0 | 317.97 | 318.0 | Banting lecture 1988. Role of insulin resistance in human disease. | G M Reaven | Diabetes | 1988 | 3056758 | No |
| 83 | 9414 | 9414.0 | 273.37 | 273.4 | The blockade of immune checkpoints in cancer immunotherapy. | Drew M Pardoll | Nat Rev Cancer | 2012 | 22437870 | No |
| 84 | 9398 | 9398.0 | 248.8 | 248.8 | Studies on transformation of Escherichia coli with plasmids. | D Hanahan | J Mol Biol | 1983 | 6345791 | Yes |
| 85 | 9345 | 9345.0 | 269.48 | 269.5 | Vitamin D deficiency. | Michael F Holick | N Engl J Med | 2007 | 17634462 | No |
| 86 | 9302 | 9302.0 | 240.67 | 240.7 | RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. | Alexandros Stamatakis | Bioinformatics | 2006 | 16928733 | Yes |
| 87 | 37080 | 9270.0 | 1356.21 | 339.1 | A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. | M E Charlson, P Pompei, K L Ales, C R MacKenzie | J Chronic Dis | 1987 | 3558716 | Yes |
| 88 | 9255 | 9255.0 | 263.1 | 263.1 | Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. | P S Thomas | Proc Natl Acad Sci U S A | 1980 | 6159641 | Yes |
| 89 | 9169 | 9169.0 | 259.25 | 259.2 | The pathogenesis of atherosclerosis: a perspective for the 1990s. | R Ross | Nature | 1993 | 8479518 | No |
| 90 | 18301 | 9150.5 | 382.08 | 191.0 | The hallmarks of cancer. | D Hanahan, R A Weinberg | Cell | 2000 | 10647931 | No |
| 91 | 9035 | 9035.0 | 232.82 | 232.8 | Integrins: versatility, modulation, and signaling in cell adhesion. | R O Hynes | Cell | 1992 | 1555235 | No |
| 92 | 26727 | 8909.0 | 682.41 | 227.5 | Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nat Protoc | 2009 | 19131956 | Yes |
| 93 | 8895 | 8895.0 | 214.52 | 214.5 | PAML 4: phylogenetic analysis by maximum likelihood. | Ziheng Yang | Mol Biol Evol | 2007 | 17483113 | Yes |
| 94 | 35540 | 8885.0 | 1147.59 | 286.9 | Bias in meta-analysis detected by a simple, graphical test. | M Egger, G Davey Smith, M Schneider, C Minder | BMJ | 1997 | 9310563 | Yes |
| 95 | 17720 | 8860.0 | 465.31 | 232.7 | Analyzing real-time PCR data by the comparative C(T) method. | Thomas D Schmittgen, Kenneth J Livak | Nat Protoc | 2008 | 18546601 | Yes |
| 96 | 52824 | 8804.0 | 3419.74 | 570.0 | Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. | Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal | CA Cancer J Clin | 2018 | 30207593 | Yes |
| 97 | 8782 | 8782.0 | 177.05 | 177.1 | Linear models and empirical bayes methods for assessing differential expression in microarray experiments. | Gordon K Smyth | Stat Appl Genet Mol Biol | 2004 | 16646809 | Yes |
| 98 | 8762 | 8762.0 | 227.87 | 227.9 | Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. | M C Hochberg | Arthritis Rheum | 1997 | 9324032 | Yes |
| 99 | 8759 | 8759.0 | 0.0 | 0.0 | Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. | D I Arnon | Plant Physiol | 1949 | 16654194 | Yes |
| 100 | 17358 | 8679.0 | 379.94 | 190.0 | Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. | Kazutoshi Takahashi, Shinya Yamanaka | Cell | 2006 | 16904174 | Yes |
| 101 | 8555 | 8555.0 | 181.06 | 181.1 | The functions of animal microRNAs. | Victor Ambros | Nature | 2004 | 15372042 | No |
| 102 | 8495 | 8495.0 | 221.98 | 222.0 | Canonical dynamics: Equilibrium phase-space distributions. | W G Hoover | Phys Rev A Gen Phys | 1985 | 9895674 | Yes |
| 103 | 25479 | 8493.0 | 675.18 | 225.1 | edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. | Mark D Robinson, Davis J McCarthy, Gordon K Smyth | Bioinformatics | 2010 | 19910308 | Yes |
| 104 | 8433 | 8433.0 | 356.89 | 356.9 | UPARSE: highly accurate OTU sequences from microbial amplicon reads. | Robert C Edgar | Nat Methods | 2013 | 23955772 | Yes |
| 105 | 8305 | 8305.0 | 216.98 | 217.0 | Apoptosis: a review of programmed cell death. | Susan Elmore | Toxicol Pathol | 2007 | 17562483 | No |
| 106 | 8301 | 8301.0 | 410.45 | 410.4 | SHELXT - integrated space-group and crystal-structure determination. | George M Sheldrick | Acta Crystallogr A Found Adv | 2015 | 25537383 | Yes |
| 107 | 8288 | 8288.0 | 0.0 | 0.0 | The assessment of anxiety states by rating. | M Hamilton | Br J Med Psychol | 1959 | 13638508 | Yes |
| 108 | 24794 | 8264.7 | 1368.99 | 456.3 | MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. | Sudhir Kumar, Glen Stecher, Koichiro Tamura | Mol Biol Evol | 2016 | 27004904 | Yes |
| 109 | 8253 | 8253.0 | 243.42 | 243.4 | AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. | R W Cox | Comput Biomed Res | 1996 | 8812068 | Yes |
| 110 | 24402 | 8134.0 | 718.98 | 239.7 | The PHQ-9: validity of a brief depression severity measure. | K Kroenke, R L Spitzer, J B Williams | J Gen Intern Med | 2001 | 11556941 | Yes |
| 111 | 8094 | 8094.0 | 196.13 | 196.1 | Solvent content of protein crystals. | B W Matthews | J Mol Biol | 1968 | 5700707 | Yes |
| 112 | 7969 | 7969.0 | 368.19 | 368.2 | Comparative fit indexes in structural models. | P M Bentler | Psychol Bull | 1990 | 2320703 | Yes |
| 113 | 7866 | 7866.0 | 217.44 | 217.4 | "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. | W N Burnette | Anal Biochem | 1981 | 6266278 | Yes |
| 114 | 7826 | 7826.0 | 211.45 | 211.4 | Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. | F Tajima | Genetics | 1989 | 2513255 | Yes |
| 115 | 15631 | 7815.5 | 380.81 | 190.4 | MrBayes 3: Bayesian phylogenetic inference under mixed models. | Fredrik Ronquist, John P Huelsenbeck | Bioinformatics | 2003 | 12912839 | Yes |
| 116 | 15594 | 7797.0 | 350.14 | 175.1 | Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. | S J Clough, A F Bent | Plant J | 1998 | 10069079 | Yes |
| 117 | 7794 | 7794.0 | 226.07 | 226.1 | A simplification of the protein assay method of Lowry et al. which is more generally applicable. | G L Peterson | Anal Biochem | 1977 | 603028 | Yes |
| 118 | 7786 | 7786.0 | 216.06 | 216.1 | The role of protein kinase C in cell surface signal transduction and tumour promotion. | Y Nishizuka | Nature | 1984 | 6232463 | No |
| 119 | 15465 | 7732.5 | 367.52 | 183.8 | BEDTools: a flexible suite of utilities for comparing genomic features. | Aaron R Quinlan, Ira M Hall | Bioinformatics | 2010 | 20110278 | Yes |
| 120 | 7730 | 7730.0 | 151.55 | 151.6 | Tumor angiogenesis: therapeutic implications. | J Folkman | N Engl J Med | 1971 | 4938153 | No |
| 121 | 15286 | 7643.0 | 512.63 | 256.3 | Three approaches to qualitative content analysis. | Hsiu-Fang Hsieh, Sarah E Shannon | Qual Health Res | 2005 | 16204405 | Yes |
| 122 | 7635 | 7635.0 | 220.25 | 220.2 | Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. | A Böyum | Scand J Clin Lab Invest Suppl | 1968 | 4179068 | Yes |
| 123 | 7634 | 7634.0 | 219.25 | 219.2 | Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. | J R Vane | Nat New Biol | 1971 | 5284360 | Yes |
| 124 | 7616 | 7616.0 | 187.81 | 187.8 | Fast robust automated brain extraction. | Stephen M Smith | Hum Brain Mapp | 2002 | 12391568 | No |
| 125 | 7582 | 7582.0 | 161.68 | 161.7 | Chromatin modifications and their function. | Tony Kouzarides | Cell | 2007 | 17320507 | No |
| 126 | 52844 | 7549.1 | 7308.52 | 1044.1 | Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. | Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie Bray | CA Cancer J Clin | 2021 | 33538338 | Yes |
| 127 | 22624 | 7541.3 | 682.95 | 227.7 | Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. | Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien | Ann Surg | 2004 | 15273542 | Yes |
| 128 | 22607 | 7535.7 | 883.5 | 294.5 | Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. | W T Friedewald, R I Levy, D S Fredrickson | Clin Chem | 1972 | 4337382 | Yes |
| 129 | 51662 | 7380.3 | 1329.81 | 190.0 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. | S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J Lipman | Nucleic Acids Res | 1997 | 9254694 | No |
| 130 | 7364 | 7364.0 | 124.11 | 124.1 | A low-viscosity epoxy resin embedding medium for electron microscopy. | A R Spurr | J Ultrastruct Res | 1969 | 4887011 | Yes |
| 131 | 7345 | 7345.0 | 232.14 | 232.1 | The Clinical Dementia Rating (CDR): current version and scoring rules. | J C Morris | Neurology | 1993 | 8232972 | Yes |
| 132 | 7341 | 7341.0 | 242.66 | 242.7 | Density-functional approximation for the correlation energy of the inhomogeneous electron gas. | J P Perdew | Phys Rev B Condens Matter | 1986 | 9938299 | Yes |
| 133 | 7274 | 7274.0 | 219.36 | 219.4 | The VideoToolbox software for visual psychophysics: transforming numbers into movies. | D G Pelli | Spat Vis | 1997 | 9176953 | Yes |
| 134 | 28913 | 7228.2 | 946.25 | 236.6 | G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. | Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner | Behav Res Methods | 2007 | 17695343 | Yes |
| 135 | 14454 | 7227.0 | 442.74 | 221.4 | AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. | Oleg Trott, Arthur J Olson | J Comput Chem | 2010 | 19499576 | Yes |
| 136 | 7060 | 7060.0 | 192.19 | 192.2 | TreeView: an application to display phylogenetic trees on personal computers. | R D Page | Comput Appl Biosci | 1996 | 8902363 | Yes |
| 137 | 7042 | 7042.0 | 247.28 | 247.3 | The Strengths and Difficulties Questionnaire: a research note. | R Goodman | J Child Psychol Psychiatry | 1997 | 9255702 | Yes |
| 138 | 13754 | 6877.0 | 351.53 | 175.8 | Continuous cultures of fused cells secreting antibody of predefined specificity. | G Köhler, C Milstein | Nature | 1975 | 1172191 | Yes |
| 139 | 13714 | 6857.0 | 323.0 | 161.5 | WGCNA: an R package for weighted correlation network analysis. | Peter Langfelder, Steve Horvath | BMC Bioinformatics | 2008 | 19114008 | Yes |
| 140 | 6837 | 6837.0 | 183.45 | 183.4 | The steroid and thyroid hormone receptor superfamily. | R M Evans | Science | 1988 | 3283939 | No |
| 141 | 6705 | 6705.0 | 0.0 | 0.0 | The thiobarbituric acid assay of sialic acids. | L Warren | J Biol Chem | 1959 | 13672998 | Yes |
| 142 | 6686 | 6686.0 | 175.81 | 175.8 | A modified poisson regression approach to prospective studies with binary data. | Guangyong Zou | Am J Epidemiol | 2004 | 15033648 | Yes |
| 143 | 13322 | 6661.0 | 717.97 | 359.0 | Intraclass correlations: uses in assessing rater reliability. | P E Shrout, J L Fleiss | Psychol Bull | 1979 | 18839484 | No |
| 144 | 13158 | 6579.0 | 0.0 | 0.0 | Statistical aspects of the analysis of data from retrospective studies of disease. | N Mantel, W Haenszel | J Natl Cancer Inst | 1959 | 13655060 | Yes |
| 145 | 13152 | 6576.0 | 307.99 | 154.0 | Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. | Y Cheng, W H Prusoff | Biochem Pharmacol | 1973 | 4202581 | Yes |
| 146 | 19689 | 6563.0 | 551.9 | 184.0 | A new generation of Ca2+ indicators with greatly improved fluorescence properties. | G Grynkiewicz, M Poenie, R Y Tsien | J Biol Chem | 1985 | 3838314 | Yes |
| 147 | 6556 | 6556.0 | 213.92 | 213.9 | Ethical guidelines for investigations of experimental pain in conscious animals. | Manfred Zimmermann | Pain | 1983 | 6877845 | No |
| 148 | 6548 | 6548.0 | 172.37 | 172.4 | Adhesion receptors of the immune system. | T A Springer | Nature | 1990 | 1974032 | No |
| 149 | 6532 | 6532.0 | 129.21 | 129.2 | Integrins: bidirectional, allosteric signaling machines. | Richard O Hynes | Cell | 2002 | 12297042 | No |
| 150 | 6512 | 6512.0 | 168.95 | 168.9 | Angiogenesis in cancer, vascular, rheumatoid and other disease. | J Folkman | Nat Med | 1995 | 7584949 | No |
| 151 | 6493 | 6493.0 | 0.0 | 0.0 | Index for rating diagnostic tests. | W J Youden | Cancer | 1950 | 15405679 | Yes |
| 152 | 12963 | 6481.5 | 359.23 | 179.6 | EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. | Arnaud Delorme, Scott Makeig | J Neurosci Methods | 2004 | 15102499 | Yes |
| 153 | 6398 | 6398.0 | 128.99 | 129.0 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel | Proc Natl Acad Sci U S A | 1985 | 3881765 | Yes |
| 154 | 6395 | 6395.0 | 112.63 | 112.6 | A Self-Rating Depression Scale. | W W Zung | Arch Gen Psychiatry | 1965 | 14221692 | Yes |
| 155 | 6385 | 6385.0 | 150.28 | 150.3 | Inflammation, atherosclerosis, and coronary artery disease. | Göran K Hansson | N Engl J Med | 2005 | 15843671 | No |
| 156 | 6353 | 6353.0 | 135.14 | 135.1 | p53, the cellular gatekeeper for growth and division. | A J Levine | Cell | 1997 | 9039259 | No |
| 157 | 12678 | 6339.0 | 351.77 | 175.9 | RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. | Bo Li, Colin N Dewey | BMC Bioinformatics | 2011 | 21816040 | Yes |
| 158 | 12631 | 6315.5 | 518.19 | 259.1 | Prediction of creatinine clearance from serum creatinine. | D W Cockcroft, M H Gault | Nephron | 1976 | 1244564 | Yes |
| 159 | 6312 | 6312.0 | 216.07 | 216.1 | An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. | Peter C Austin | Multivariate Behav Res | 2011 | 21818162 | Yes |
| 160 | 12615 | 6307.5 | 431.06 | 215.5 | The meaning and use of the area under a receiver operating characteristic (ROC) curve. | J A Hanley, B J McNeil | Radiology | 1982 | 7063747 | Yes |
| 161 | 6241 | 6241.0 | 135.95 | 135.9 | Inflammation in atherosclerosis. | Peter Libby | Nature | 2002 | 12490960 | No |
| 162 | 6209 | 6209.0 | 146.2 | 146.2 | Biochemistry and molecular cell biology of diabetic complications. | M Brownlee | Nature | 2001 | 11742414 | Yes |
| 163 | 6206 | 6206.0 | 142.41 | 142.4 | Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. | J Castresana | Mol Biol Evol | 2000 | 10742046 | Yes |
| 164 | 12374 | 6187.0 | 834.95 | 417.5 | A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. | Terry K Koo, Mae Y Li | J Chiropr Med | 2016 | 27330520 | Yes |
| 165 | 6155 | 6155.0 | 143.66 | 143.7 | Free radicals in the physiological control of cell function. | Wulf Dröge | Physiol Rev | 2002 | 11773609 | No |
| 166 | 6141 | 6141.0 | 114.63 | 114.6 | BLAT--the BLAST-like alignment tool. | W James Kent | Genome Res | 2002 | 11932250 | Yes |
| 167 | 12248 | 6124.0 | 433.18 | 216.6 | A rapid alkaline extraction procedure for screening recombinant plasmid DNA. | H C Birnboim, J Doly | Nucleic Acids Res | 1979 | 388356 | Yes |
| 168 | 18310 | 6103.3 | 905.27 | 301.8 | Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. | H Ohkawa, N Ohishi, K Yagi | Anal Biochem | 1979 | 36810 | Yes |
| 169 | 6097 | 6097.0 | 270.99 | 271.0 | Interrater reliability: the kappa statistic. | Mary L McHugh | Biochem Med (Zagreb) | 2012 | 23092060 | Yes |
| 170 | 18288 | 6096.0 | 641.49 | 213.8 | Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. | Allison Tong, Peter Sainsbury, Jonathan Craig | Int J Qual Health Care | 2007 | 17872937 | Yes |
| 171 | 6089 | 6089.0 | 148.98 | 149.0 | Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. | T A Springer | Cell | 1994 | 7507411 | No |
| 172 | 6033 | 6033.0 | 152.25 | 152.2 | G proteins: transducers of receptor-generated signals. | A G Gilman | Annu Rev Biochem | 1987 | 3113327 | No |
| 173 | 6032 | 6032.0 | 145.58 | 145.6 | Inflammation and metabolic disorders. | Gökhan S Hotamisligil | Nature | 2006 | 17167474 | No |
| 174 | 6028 | 6028.0 | 152.08 | 152.1 | Inositol trisphosphate and calcium signalling. | M J Berridge | Nature | 1993 | 8381210 | No |
| 175 | 23967 | 5991.8 | 769.14 | 192.3 | Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. | J M Chirgwin, A E Przybyla, R J MacDonald, W J Rutter | Biochemistry | 1979 | 518835 | Yes |
| 176 | 11939 | 5969.5 | 290.46 | 145.2 | MRBAYES: Bayesian inference of phylogenetic trees. | J P Huelsenbeck, F Ronquist | Bioinformatics | 2001 | 11524383 | Yes |
| 177 | 5930 | 5930.0 | 136.72 | 136.7 | Antimicrobial peptides of multicellular organisms. | Michael Zasloff | Nature | 2002 | 11807545 | Yes |
| 178 | 5880 | 5880.0 | 278.09 | 278.1 | Minimap2: pairwise alignment for nucleotide sequences. | Heng Li | Bioinformatics | 2018 | 29750242 | Yes |
| 179 | 11675 | 5837.5 | 268.37 | 134.2 | Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. | W Kabsch, C Sander | Biopolymers | 1983 | 6667333 | Yes |
| 180 | 11673 | 5836.5 | 253.81 | 126.9 | One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. | K A Datsenko, B L Wanner | Proc Natl Acad Sci U S A | 2000 | 10829079 | Yes |
| 181 | 11638 | 5819.0 | 317.36 | 158.7 | Neuropathological stageing of Alzheimer-related changes. | H Braak, E Braak | Acta Neuropathol | 1991 | 1759558 | No |
| 182 | 5812 | 5812.0 | 178.55 | 178.6 | Modification of seizure activity by electrical stimulation. II. Motor seizure. | R J Racine | Electroencephalogr Clin Neurophysiol | 1972 | 4110397 | Yes |
| 183 | 5799 | 5799.0 | 75.84 | 75.8 | The Environment And Disease: Association Or Causation? | A B Hill | Proc R Soc Med | 1965 | 14283879 | Yes |
| 184 | 11517 | 5758.5 | 303.67 | 151.8 | Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. | Florian Weigend, Reinhart Ahlrichs | Phys Chem Chem Phys | 2005 | 16240044 | Yes |
| 185 | 5701 | 5701.0 | 142.83 | 142.8 | Apoptosis in the pathogenesis and treatment of disease. | C B Thompson | Science | 1995 | 7878464 | No |
| 186 | 11402 | 5701.0 | 458.45 | 229.2 | The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. | T Omura, R Sato | J Biol Chem | 1964 | 14209971 | Yes |
| 187 | 5695 | 5695.0 | 126.04 | 126.0 | MUSCLE: a multiple sequence alignment method with reduced time and space complexity. | Robert C Edgar | BMC Bioinformatics | 2004 | 15318951 | Yes |
| 188 | 11380 | 5690.0 | 250.65 | 125.3 | Dendritic cells and the control of immunity. | J Banchereau, R M Steinman | Nature | 1998 | 9521319 | No |
| 189 | 5686 | 5686.0 | 158.86 | 158.9 | A fast diffeomorphic image registration algorithm. | John Ashburner | Neuroimage | 2007 | 17761438 | Yes |
| 190 | 11273 | 5636.5 | 0.0 | 0.0 | A series of normal stages in the development of the chick embryo. | V Hamburger, H L Hamilton | J Morphol | 1951 | 24539719 | Yes |
| 191 | 5633 | 5633.0 | 184.34 | 184.3 | Whatever happened to qualitative description? | M Sandelowski | Res Nurs Health | 2000 | 10940958 | No |
| 192 | 5603 | 5603.0 | 177.3 | 177.3 | jModelTest: phylogenetic model averaging. | David Posada | Mol Biol Evol | 2008 | 18397919 | Yes |
| 193 | 5584 | 5584.0 | 133.37 | 133.4 | Development of a rating scale for primary depressive illness. | M Hamilton | Br J Soc Clin Psychol | 1967 | 6080235 | Yes |
| 194 | 5582 | 5582.0 | 106.79 | 106.8 | Evaluation of survival data and two new rank order statistics arising in its consideration. | N Mantel | Cancer Chemother Rep | 1966 | 5910392 | Yes |
| 195 | 5578 | 5578.0 | 0.0 | 0.0 | Aging: a theory based on free radical and radiation chemistry. | D Harman | J Gerontol | 1956 | 13332224 | Yes |
| 196 | 5549 | 5549.0 | 221.19 | 221.2 | Orienting of attention. | M I Posner | Q J Exp Psychol | 1980 | 7367577 | Yes |
| 197 | 5537 | 5537.0 | 92.65 | 92.7 | Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. | F Tietze | Anal Biochem | 1969 | 4388022 | Yes |
| 198 | 5513 | 5513.0 | 119.35 | 119.3 | The biochemistry of apoptosis. | M O Hengartner | Nature | 2000 | 11048727 | No |
| 199 | 5511 | 5511.0 | 92.73 | 92.7 | Mutation and cancer: statistical study of retinoblastoma. | A G Knudson | Proc Natl Acad Sci U S A | 1971 | 5279523 | Yes |
| 200 | 10978 | 5489.0 | 254.78 | 127.4 | A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. | Stéphane Guindon, Olivier Gascuel | Syst Biol | 2003 | 14530136 | Yes |
| 201 | 16439 | 5479.7 | 494.17 | 164.7 | A simple salting out procedure for extracting DNA from human nucleated cells. | S A Miller, D D Dykes, H F Polesky | Nucleic Acids Res | 1988 | 3344216 | Yes |
| 202 | 10944 | 5472.0 | 932.67 | 466.3 | Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. | Zunyou Wu, Jennifer M McGoogan | JAMA | 2020 | 32091533 | Yes |
| 203 | 10938 | 5469.0 | 362.49 | 181.2 | Operating characteristics of a rank correlation test for publication bias. | C B Begg, M Mazumdar | Biometrics | 1994 | 7786990 | Yes |
| 204 | 10930 | 5465.0 | 231.13 | 115.6 | Inflammation and cancer. | Lisa M Coussens, Zena Werb | Nature | 2002 | 12490959 | No |
| 205 | 10925 | 5462.5 | 287.21 | 143.6 | Sequencing end-labeled DNA with base-specific chemical cleavages. | A M Maxam, W Gilbert | Methods Enzymol | 1980 | 6246368 | Yes |
| 206 | 10862 | 5431.0 | 276.82 | 138.4 | Differential expression analysis for sequence count data. | Simon Anders, Wolfgang Huber | Genome Biol | 2010 | 20979621 | Yes |
| 207 | 5391 | 5391.0 | 164.41 | 164.4 | Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. | Ilan H Meyer | Psychol Bull | 2003 | 12956539 | No |
| 208 | 5358 | 5358.0 | 121.43 | 121.4 | Tandem repeats finder: a program to analyze DNA sequences. | G Benson | Nucleic Acids Res | 1999 | 9862982 | Yes |
| 209 | 10704 | 5352.0 | 300.1 | 150.1 | MODELTEST: testing the model of DNA substitution. | D Posada, K A Crandall | Bioinformatics | 1998 | 9918953 | Yes |
| 210 | 5336 | 5336.0 | 140.34 | 140.3 | Mild cognitive impairment as a diagnostic entity. | R C Petersen | J Intern Med | 2004 | 15324362 | No |
| 211 | 5332 | 5332.0 | 136.86 | 136.9 | The Cambridge Structural Database: a quarter of a million crystal structures and rising. | Frank H Allen | Acta Crystallogr B | 2002 | 12037359 | Yes |
| 212 | 5316 | 5316.0 | 157.3 | 157.3 | Developments of a water-maze procedure for studying spatial learning in the rat. | R Morris | J Neurosci Methods | 1984 | 6471907 | Yes |
| 213 | 5298 | 5298.0 | 134.96 | 135.0 | New M13 vectors for cloning. | J Messing | Methods Enzymol | 1983 | 6310323 | Yes |
| 214 | 26453 | 5290.6 | 714.32 | 142.9 | The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. | J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G Higgins | Nucleic Acids Res | 1997 | 9396791 | Yes |
| 215 | 15864 | 5288.0 | 594.18 | 198.1 | The positive and negative syndrome scale (PANSS) for schizophrenia. | S R Kay, A Fiszbein, L A Opler | Schizophr Bull | 1987 | 3616518 | Yes |
| 216 | 10569 | 5284.5 | 490.99 | 245.5 | A new depression scale designed to be sensitive to change. | S A Montgomery, M Asberg | Br J Psychiatry | 1979 | 444788 | Yes |
| 217 | 10569 | 5284.5 | 0.0 | 0.0 | A quantitative description of membrane current and its application to conduction and excitation in nerve. | A L Hodgkin, A F Huxley | J Physiol | 1952 | 12991237 | Yes |
| 218 | 5284 | 5284.0 | 102.58 | 102.6 | Epithelial-mesenchymal transitions in tumour progression. | Jean Paul Thiery | Nat Rev Cancer | 2002 | 12189386 | No |
| 219 | 5275 | 5275.0 | 200.54 | 200.5 | Revisiting the behavioral model and access to medical care: does it matter? | R M Andersen | J Health Soc Behav | 1995 | 7738325 | Yes |
| 220 | 5275 | 5275.0 | 127.4 | 127.4 | The NF-kappa B and I kappa B proteins: new discoveries and insights. | A S Baldwin | Annu Rev Immunol | 1996 | 8717528 | No |
| 221 | 5260 | 5260.0 | 151.76 | 151.8 | Studies and perspectives of protein kinase C. | Y Nishizuka | Science | 1986 | 3014651 | No |
| 222 | 10503 | 5251.5 | 229.62 | 114.8 | MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. | Jürgen Cox, Matthias Mann | Nat Biotechnol | 2008 | 19029910 | Yes |
| 223 | 5250 | 5250.0 | 142.69 | 142.7 | How mitochondria produce reactive oxygen species. | Michael P Murphy | Biochem J | 2009 | 19061483 | No |
| 224 | 5221 | 5221.0 | 0.0 | 0.0 | [A micro-method of immuno-electrophoresis]. | J J Scheidegger | Int Arch Allergy Appl Immunol | 1955 | 13262900 | Yes |
| 225 | 5201 | 5201.0 | 53.39 | 53.4 | The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. | P Lauren | Acta Pathol Microbiol Scand | 1965 | 14320675 | Yes |
| 226 | 15601 | 5200.3 | 384.28 | 128.1 | Inference of population structure using multilocus genotype data. | J K Pritchard, M Stephens, P Donnelly | Genetics | 2000 | 10835412 | Yes |
| 227 | 5200 | 5200.0 | 188.78 | 188.8 | Oxygen-derived free radicals in postischemic tissue injury. | J M McCord | N Engl J Med | 1985 | 2981404 | No |
| 228 | 5191 | 5191.0 | 66.12 | 66.1 | Selective extraction of polyoma DNA from infected mouse cell cultures. | B Hirt | J Mol Biol | 1967 | 4291934 | Yes |
| 229 | 10301 | 5150.5 | 365.31 | 182.7 | The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. | R F Furchgott, J V Zawadzki | Nature | 1980 | 6253831 | Yes |
| 230 | 30841 | 5140.2 | 1077.32 | 179.6 | Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. | Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G Conde | J Biomed Inform | 2009 | 18929686 | Yes |
| 231 | 5122 | 5122.0 | 124.35 | 124.3 | Emotion circuits in the brain. | J E LeDoux | Annu Rev Neurosci | 2000 | 10845062 | No |
| 232 | 20482 | 5120.5 | 521.06 | 130.3 | Features and development of Coot. | P Emsley, B Lohkamp, W G Scott, K Cowtan | Acta Crystallogr D Biol Crystallogr | 2010 | 20383002 | Yes |
| 233 | 5104 | 5104.0 | 101.67 | 101.7 | Rho GTPases and the actin cytoskeleton. | A Hall | Science | 1998 | 9438836 | No |
| 234 | 10196 | 5098.0 | 270.46 | 135.2 | Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. | H Schägger, G von Jagow | Anal Biochem | 1987 | 2449095 | Yes |
| 235 | 10185 | 5092.5 | 242.0 | 121.0 | Comparative protein modelling by satisfaction of spatial restraints. | A Sali, T L Blundell | J Mol Biol | 1993 | 8254673 | Yes |
| 236 | 5085 | 5085.0 | 101.99 | 102.0 | Targeting HIF-1 for cancer therapy. | Gregg L Semenza | Nat Rev Cancer | 2003 | 13130303 | No |
| 237 | 5077 | 5077.0 | 186.9 | 186.9 | Analyzing Tables Of Statistical Tests. | William R Rice | Evolution | 1989 | 28568501 | Yes |
| 238 | 5070 | 5070.0 | 198.29 | 198.3 | The need for a new medical model: a challenge for biomedicine. | G L Engel | Science | 1977 | 847460 | Yes |
| 239 | 10119 | 5059.5 | 219.01 | 109.5 | The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. | John Hardy, Dennis J Selkoe | Science | 2002 | 12130773 | No |
| 240 | 4991 | 4991.0 | 231.66 | 231.7 | Executive functions. | Adele Diamond | Annu Rev Psychol | 2013 | 23020641 | No |
| 241 | 14942 | 4980.7 | 1017.5 | 339.2 | Cancer statistics, 2019. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2019 | 30620402 | Yes |
| 242 | 14938 | 4979.3 | 539.2 | 179.7 | Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. | S M Hsu, L Raine, H Fanger | J Histochem Cytochem | 1981 | 6166661 | Yes |
| 243 | 24799 | 4959.8 | 1075.8 | 215.2 | MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. | Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir Kumar | Mol Biol Evol | 2013 | 24132122 | Yes |
| 244 | 4951 | 4951.0 | 129.38 | 129.4 | A protein binding assay for adenosine 3':5'-cyclic monophosphate. | A G Gilman | Proc Natl Acad Sci U S A | 1970 | 4318781 | Yes |
| 245 | 9883 | 4941.5 | 235.17 | 117.6 | A genetic model for colorectal tumorigenesis. | E R Fearon, B Vogelstein | Cell | 1990 | 2188735 | No |
| 246 | 4918 | 4918.0 | 113.49 | 113.5 | The clonal evolution of tumor cell populations. | P C Nowell | Science | 1976 | 959840 | Yes |
| 247 | 4910 | 4910.0 | 179.94 | 179.9 | FreeSurfer. | Bruce Fischl | Neuroimage | 2012 | 22248573 | No |
| 248 | 4909 | 4909.0 | 140.42 | 140.4 | Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. | C B Laurell | Anal Biochem | 1966 | 5959431 | Yes |
| 249 | 9797 | 4898.5 | 351.09 | 175.5 | Ligand: a versatile computerized approach for characterization of ligand-binding systems. | P J Munson, D Rodbard | Anal Biochem | 1980 | 6254391 | Yes |
| 250 | 14632 | 4877.3 | 1248.66 | 416.2 | Cancer statistics, 2020. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2020 | 31912902 | Yes |
| 251 | 14613 | 4871.0 | 392.98 | 131.0 | Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. | C Yanisch-Perron, J Vieira, J Messing | Gene | 1985 | 2985470 | Yes |
| 252 | 4849 | 4849.0 | 147.41 | 147.4 | Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. | W H Harris | J Bone Joint Surg Am | 1969 | 5783851 | Yes |
| 253 | 4846 | 4846.0 | 97.56 | 97.6 | An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. | M Kozak | Nucleic Acids Res | 1987 | 3313277 | No |
| 254 | 4828 | 4828.0 | 90.06 | 90.1 | DNA methylation patterns and epigenetic memory. | Adrian Bird | Genes Dev | 2002 | 11782440 | No |
| 255 | 24134 | 4826.8 | 409.74 | 81.9 | An inventory for measuring depression. | A T Beck, C H Ward, M Mendelson, J Mock, J Erbaugh | Arch Gen Psychiatry | 1961 | 13688369 | Yes |
| 256 | 14460 | 4820.0 | 571.91 | 190.6 | A global measure of perceived stress. | S Cohen, T Kamarck, R Mermelstein | J Health Soc Behav | 1983 | 6668417 | Yes |
| 257 | 14447 | 4815.7 | 357.24 | 119.1 | A comprehensive set of sequence analysis programs for the VAX. | J Devereux, P Haeberli, O Smithies | Nucleic Acids Res | 1984 | 6546423 | Yes |
| 258 | 9619 | 4809.5 | 260.03 | 130.0 | The rise of graphene. | A K Geim, K S Novoselov | Nat Mater | 2007 | 17330084 | Yes |
| 259 | 9596 | 4798.0 | 175.22 | 87.6 | Assessment of older people: self-maintaining and instrumental activities of daily living. | M P Lawton, E M Brody | Gerontologist | 1969 | 5349366 | Yes |
| 260 | 14387 | 4795.7 | 0.0 | 0.0 | Determination of serum proteins by means of the biuret reaction. | A G Gornall, C J Bardawill, M M David | J Biol Chem | 1949 | 18110453 | Yes |
| 261 | 9581 | 4790.5 | 158.68 | 79.3 | Functional Evaluation: The Barthel Index. | F I Mahoney, D W Barthel | Md State Med J | 1965 | 14258950 | Yes |
| 262 | 4788 | 4788.0 | 138.12 | 138.1 | Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. | M Rodbell | J Biol Chem | 1964 | 14169133 | Yes |
| 263 | 4777 | 4777.0 | 107.1 | 107.1 | ras oncogenes in human cancer: a review. | J L Bos | Cancer Res | 1989 | 2547513 | No |
| 264 | 9545 | 4772.5 | 324.16 | 162.1 | Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. | U H Graneheim, B Lundman | Nurse Educ Today | 2004 | 14769454 | No |
| 265 | 4762 | 4762.0 | 104.72 | 104.7 | Cancer cell cycles. | C J Sherr | Science | 1996 | 8939849 | No |
| 266 | 9504 | 4752.0 | 158.27 | 79.1 | A new technique for the assay of infectivity of human adenovirus 5 DNA. | F L Graham, A J van der Eb | Virology | 1973 | 4705382 | Yes |
| 267 | 9503 | 4751.5 | 211.09 | 105.5 | Parkinsonism: onset, progression and mortality. | M M Hoehn, M D Yahr | Neurology | 1967 | 6067254 | Yes |
| 268 | 9425 | 4712.5 | 237.16 | 118.6 | Improved tools for biological sequence comparison. | W R Pearson, D J Lipman | Proc Natl Acad Sci U S A | 1988 | 3162770 | Yes |
| 269 | 9402 | 4701.0 | 386.94 | 193.5 | phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. | Paul J McMurdie, Susan Holmes | PLoS One | 2013 | 23630581 | Yes |
| 270 | 4700 | 4700.0 | 156.95 | 156.9 | The pathogenesis of atherosclerosis--an update. | R Ross | N Engl J Med | 1986 | 3511384 | No |
| 271 | 4687 | 4687.0 | 210.98 | 211.0 | The McGill Pain Questionnaire: major properties and scoring methods. | Ronald Melzack | Pain | 1975 | 1235985 | Yes |
| 272 | 14057 | 4685.7 | 485.43 | 161.8 | Nitric oxide: physiology, pathophysiology, and pharmacology. | S Moncada, R M Palmer, E A Higgs | Pharmacol Rev | 1991 | 1852778 | No |
| 273 | 14045 | 4681.7 | 306.47 | 102.2 | Refinement of macromolecular structures by the maximum-likelihood method. | G N Murshudov, A A Vagin, E J Dodson | Acta Crystallogr D Biol Crystallogr | 1997 | 15299926 | Yes |
| 274 | 4674 | 4674.0 | 129.91 | 129.9 | Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. | P Matsudaira | J Biol Chem | 1987 | 3611052 | Yes |
| 275 | 4673 | 4673.0 | 102.83 | 102.8 | Alzheimer's disease: genes, proteins, and therapy. | D J Selkoe | Physiol Rev | 2001 | 11274343 | No |
| 276 | 9342 | 4671.0 | 254.66 | 127.3 | Ab initio molecular dynamics for liquid metals. | G Kresse, J Hafner | Phys Rev B Condens Matter | 1993 | 10004490 | Yes |
| 277 | 4670 | 4670.0 | 76.19 | 76.2 | Aggregation of blood platelets by adenosine diphosphate and its reversal. | G V Born | Nature | 1962 | 13871375 | Yes |
| 278 | 4647 | 4647.0 | 40.36 | 40.4 | The Limited In Vitro Lifetime Of Human Diploid Cell Strains. | L Hayflick | Exp Cell Res | 1965 | 14315085 | Yes |
| 279 | 9284 | 4642.0 | 338.61 | 169.3 | Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. | Kristopher J Preacher, Andrew F Hayes | Behav Res Methods | 2008 | 18697684 | Yes |
| 280 | 4641 | 4641.0 | 120.3 | 120.3 | A rapid banding technique for human chromosomes. | M Seabright | Lancet | 1971 | 4107917 | Yes |
| 281 | 4641 | 4641.0 | 102.91 | 102.9 | Prions. | S B Prusiner | Proc Natl Acad Sci U S A | 1998 | 9811807 | No |
| 282 | 18545 | 4636.2 | 532.63 | 133.2 | MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. | Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir Kumar | Mol Biol Evol | 2007 | 17488738 | Yes |
| 283 | 13894 | 4631.3 | 609.28 | 203.1 | Development and validation of brief measures of positive and negative affect: the PANAS scales. | D Watson, L A Clark, A Tellegen | J Pers Soc Psychol | 1988 | 3397865 | Yes |
| 284 | 18440 | 4610.0 | 298.77 | 74.7 | A new and rapid colorimetric determination of acetylcholinesterase activity. | G L Ellman, K D Courtney, V Andres, R M Feather-Stone | Biochem Pharmacol | 1961 | 13726518 | Yes |
| 285 | 9143 | 4571.5 | 139.96 | 70.0 | Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). | J M McCord, I Fridovich | J Biol Chem | 1969 | 5389100 | Yes |
| 286 | 9141 | 4570.5 | 202.74 | 101.4 | Primer3 on the WWW for general users and for biologist programmers. | S Rozen, H Skaletsky | Methods Mol Biol | 2000 | 10547847 | Yes |
| 287 | 4562 | 4562.0 | 93.57 | 93.6 | Alternative activation of macrophages. | Siamon Gordon | Nat Rev Immunol | 2003 | 12511873 | No |
| 288 | 4521 | 4521.0 | 140.88 | 140.9 | Updating P300: an integrative theory of P3a and P3b. | John Polich | Clin Neurophysiol | 2007 | 17573239 | No |
| 289 | 4520 | 4520.0 | 96.79 | 96.8 | ras genes. | M Barbacid | Annu Rev Biochem | 1987 | 3304147 | No |
| 290 | 13512 | 4504.0 | 430.86 | 143.6 | Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. | E R DeLong, D M DeLong, D L Clarke-Pearson | Biometrics | 1988 | 3203132 | Yes |
| 291 | 17979 | 4494.8 | 538.8 | 134.7 | clusterProfiler: an R package for comparing biological themes among gene clusters. | Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu He | OMICS | 2012 | 22455463 | Yes |
| 292 | 4494 | 4494.0 | 114.01 | 114.0 | The genetical evolution of social behaviour. I. | W D Hamilton | J Theor Biol | 1964 | 5875341 | Yes |
| 293 | 8985 | 4492.5 | 214.68 | 107.3 | Collective dynamics of 'small-world' networks. | D J Watts, S H Strogatz | Nature | 1998 | 9623998 | Yes |
| 294 | 4482 | 4482.0 | 102.64 | 102.6 | Cancer. p53, guardian of the genome. | D P Lane | Nature | 1992 | 1614522 | No |
| 295 | 13433 | 4477.7 | 480.22 | 160.1 | HTSeq--a Python framework to work with high-throughput sequencing data. | Simon Anders, Paul Theodor Pyl, Wolfgang Huber | Bioinformatics | 2015 | 25260700 | Yes |
| 296 | 4476 | 4476.0 | 106.26 | 106.3 | Why most published research findings are false. | John P A Ioannidis | PLoS Med | 2005 | 16060722 | Yes |
| 297 | 4475 | 4475.0 | 90.25 | 90.2 | Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. | M Kozak | Cell | 1986 | 3943125 | Yes |
| 298 | 8950 | 4475.0 | 0.0 | 0.0 | A simplified method of evaluating dose-effect experiments. | J T Litchfield, F Wilcoxon | J Pharmacol Exp Ther | 1949 | 18152921 | Yes |
| 299 | 13416 | 4472.0 | 439.07 | 146.4 | featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. | Yang Liao, Gordon K Smyth, Wei Shi | Bioinformatics | 2014 | 24227677 | Yes |
| 300 | 26742 | 4457.0 | 919.96 | 153.3 | Global cancer statistics. | Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David Forman | CA Cancer J Clin | 2011 | 21296855 | Yes |
| 301 | 4437 | 4437.0 | 107.62 | 107.6 | A new method for predicting signal sequence cleavage sites. | G von Heijne | Nucleic Acids Res | 1986 | 3714490 | Yes |
| 302 | 8859 | 4429.5 | 237.17 | 118.6 | A synaptic model of memory: long-term potentiation in the hippocampus. | T V Bliss, G L Collingridge | Nature | 1993 | 8421494 | No |
| 303 | 4406 | 4406.0 | 90.39 | 90.4 | Wnt/beta-catenin signaling in development and disease. | Hans Clevers | Cell | 2006 | 17081971 | No |
| 304 | 13207 | 4402.3 | 568.64 | 189.5 | Deep learning. | Yann LeCun, Yoshua Bengio, Geoffrey Hinton | Nature | 2015 | 26017442 | No |
| 305 | 8771 | 4385.5 | 202.74 | 101.4 | SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. | N Guex, M C Peitsch | Electrophoresis | 1997 | 9504803 | Yes |
| 306 | 8767 | 4383.5 | 161.07 | 80.5 | A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. | W M Bonner, R A Laskey | Eur J Biochem | 1974 | 4850204 | Yes |
| 307 | 8762 | 4381.0 | 219.17 | 109.6 | Assessment of coma and impaired consciousness. A practical scale. | G Teasdale, B Jennett | Lancet | 1974 | 4136544 | Yes |
| 308 | 4376 | 4376.0 | 82.15 | 82.2 | The detection of disease clustering and a generalized regression approach. | N Mantel | Cancer Res | 1967 | 6018555 | Yes |
| 309 | 4371 | 4371.0 | 83.29 | 83.3 | The phosphoinositide 3-kinase pathway. | Lewis C Cantley | Science | 2002 | 12040186 | No |
| 310 | 4364 | 4364.0 | 158.89 | 158.9 | EuroQol: the current state of play. | R Brooks | Health Policy | 1996 | 10158943 | No |
| 311 | 8719 | 4359.5 | 323.96 | 162.0 | The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. | I F Benzie, J J Strain | Anal Biochem | 1996 | 8660627 | Yes |
| 312 | 8714 | 4357.0 | 251.64 | 125.8 | Estimating F-Statistics For The Analysis Of Population Structure. | B S Weir, C Clark Cockerham | Evolution | 1984 | 28563791 | Yes |
| 313 | 4352 | 4352.0 | 221.99 | 222.0 | Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. | M M Mesulam | J Histochem Cytochem | 1978 | 24068 | Yes |
| 314 | 17397 | 4349.2 | 545.32 | 136.3 | A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. | Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge Krieg | J Chem Phys | 2010 | 20423165 | Yes |
| 315 | 26034 | 4339.0 | 951.38 | 158.6 | MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. | Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir Kumar | Mol Biol Evol | 2011 | 21546353 | Yes |
| 316 | 4334 | 4334.0 | 111.72 | 111.7 | Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. | Y Nishizuka | Science | 1992 | 1411571 | No |
| 317 | 13000 | 4333.3 | 627.22 | 209.1 | Cancer statistics, 2016. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2016 | 26742998 | Yes |
| 318 | 8653 | 4326.5 | 357.5 | 178.8 | The timed "Up & Go": a test of basic functional mobility for frail elderly persons. | D Podsiadlo, S Richardson | J Am Geriatr Soc | 1991 | 1991946 | Yes |
| 319 | 4319 | 4319.0 | 101.29 | 101.3 | Mechanisms of angiogenesis. | W Risau | Nature | 1997 | 9109485 | No |
| 320 | 8601 | 4300.5 | 0.0 | 0.0 | Radiological assessment of osteo-arthrosis. | J H Kellgren, J S Lawrence | Ann Rheum Dis | 1957 | 13498604 | Yes |
| 321 | 4300 | 4300.0 | 128.51 | 128.5 | Glutamate neurotoxicity and diseases of the nervous system. | D W Choi | Neuron | 1988 | 2908446 | No |
| 322 | 12883 | 4294.3 | 746.62 | 248.9 | Cancer statistics, 2018. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2018 | 29313949 | Yes |
| 323 | 4293 | 4293.0 | 91.11 | 91.1 | Protein production by auto-induction in high density shaking cultures. | F William Studier | Protein Expr Purif | 2005 | 15915565 | Yes |
| 324 | 8581 | 4290.5 | 124.47 | 62.2 | Preparation of iodine-131 labelled human growth hormone of high specific activity. | W M Hunter, F C Greenwood | Nature | 1962 | 14450081 | Yes |
| 325 | 4284 | 4284.0 | 160.38 | 160.4 | Measuring the accuracy of diagnostic systems. | J A Swets | Science | 1988 | 3287615 | No |
| 326 | 4272 | 4272.0 | 113.29 | 113.3 | The molecular heterogeneity of protein kinase C and its implications for cellular regulation. | Y Nishizuka | Nature | 1988 | 3045562 | No |
| 327 | 4270 | 4270.0 | 0.0 | 0.0 | New methods for calculating metabolic rate with special reference to protein metabolism. | J B De B Weir | J Physiol | 1949 | 15394301 | Yes |
| 328 | 4263 | 4263.0 | 92.36 | 92.4 | Apoptosis by death factor. | S Nagata | Cell | 1997 | 9039262 | No |
| 329 | 8521 | 4260.5 | 312.59 | 156.3 | Multiwfn: a multifunctional wavefunction analyzer. | Tian Lu, Feiwu Chen | J Comput Chem | 2012 | 22162017 | Yes |
| 330 | 4242 | 4242.0 | 0.0 | 0.0 | Estimation of nuclear population from microtome sections. | M Abercrombie | Anat Rec | 1946 | 21015608 | Yes |
| 331 | 25417 | 4236.2 | 829.44 | 138.2 | Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. | D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C Turner | Diabetologia | 1985 | 3899825 | Yes |
| 332 | 4236 | 4236.0 | 0.0 | 0.0 | The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. | T Nash | Biochem J | 1953 | 13105648 | Yes |
| 333 | 4235 | 4235.0 | 0.0 | 0.0 | Evolution in Mendelian Populations. | S Wright | Genetics | 1931 | 17246615 | Yes |
| 334 | 4231 | 4231.0 | 87.45 | 87.5 | The retinoblastoma protein and cell cycle control. | R A Weinberg | Cell | 1995 | 7736585 | No |
| 335 | 4224 | 4224.0 | 0.0 | 0.0 | Amino acid metabolism in mammalian cell cultures. | H Eagle | Science | 1959 | 13675766 | Yes |
| 336 | 4220 | 4220.0 | 109.68 | 109.7 | Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. | A H Wyllie | Nature | 1980 | 6245367 | Yes |
| 337 | 29533 | 4219.0 | 648.97 | 92.7 | UCSF Chimera--a visualization system for exploratory research and analysis. | Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin | J Comput Chem | 2004 | 15264254 | Yes |
| 338 | 4216 | 4216.0 | 93.88 | 93.9 | Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. | S Henikoff | Gene | 1984 | 6235151 | Yes |
| 339 | 4212 | 4212.0 | 91.04 | 91.0 | Atherosclerosis. | A J Lusis | Nature | 2000 | 11001066 | No |
| 340 | 4206 | 4206.0 | 75.86 | 75.9 | Generalized lacZ expression with the ROSA26 Cre reporter strain. | P Soriano | Nat Genet | 1999 | 9916792 | Yes |
| 341 | 12594 | 4198.0 | 466.58 | 155.5 | A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. | J Ware, M Kosinski, S D Keller | Med Care | 1996 | 8628042 | Yes |
| 342 | 4196 | 4196.0 | 0.0 | 0.0 | A relation between non-esterified fatty acids in plasma and the metabolism of glucose. | V P Dole | J Clin Invest | 1956 | 13286333 | Yes |
| 343 | 4192 | 4192.0 | 198.54 | 198.5 | Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. | Daniël Lakens | Front Psychol | 2013 | 24324449 | No |
| 344 | 4186 | 4186.0 | 92.75 | 92.8 | PAML: a program package for phylogenetic analysis by maximum likelihood. | Z Yang | Comput Appl Biosci | 1997 | 9367129 | Yes |
| 345 | 4182 | 4182.0 | 109.11 | 109.1 | Staphylococcus aureus infections. | F D Lowy | N Engl J Med | 1998 | 9709046 | No |
| 346 | 4181 | 4181.0 | 87.12 | 87.1 | Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. | C J Marshall | Cell | 1995 | 7834738 | No |
| 347 | 8344 | 4172.0 | 223.42 | 111.7 | Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii. | Daniel E Voth, Robert A Heinzen | Cell Microbiol | 2007 | 17381428 | No |
| 348 | 4167 | 4167.0 | 129.44 | 129.4 | Emerging adulthood. A theory of development from the late teens through the twenties. | J J Arnett | Am Psychol | 2000 | 10842426 | Yes |
| 349 | 8333 | 4166.5 | 215.24 | 107.6 | Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. | D E Paglia, W N Valentine | J Lab Clin Med | 1967 | 6066618 | Yes |
| 350 | 16651 | 4162.8 | 623.52 | 155.9 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | Ann Intern Med | 2009 | 19622511 | No |
| 351 | 4152 | 4152.0 | 50.54 | 50.5 | Bone: formation by autoinduction. | M R Urist | Science | 1965 | 5319761 | Yes |
| 352 | 4146 | 4146.0 | 152.21 | 152.2 | A concordance correlation coefficient to evaluate reproducibility. | L I Lin | Biometrics | 1989 | 2720055 | Yes |
| 353 | 4144 | 4144.0 | 173.27 | 173.3 | Determination of protein: a modification of the Lowry method that gives a linear photometric response. | E F Hartree | Anal Biochem | 1972 | 4115981 | Yes |
| 354 | 8281 | 4140.5 | 177.71 | 88.9 | Genomic sequencing. | G M Church, W Gilbert | Proc Natl Acad Sci U S A | 1984 | 6326095 | Yes |
| 355 | 4133 | 4133.0 | 0.0 | 0.0 | The determination of enzyme inhibitor constants. | M Dixon | Biochem J | 1953 | 13093635 | Yes |
| 356 | 37136 | 4126.2 | 938.86 | 104.3 | The Sequence Alignment/Map format and SAMtools. | Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin | Bioinformatics | 2009 | 19505943 | Yes |
| 357 | 8225 | 4112.5 | 262.6 | 131.3 | DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. | P Librado, J Rozas | Bioinformatics | 2009 | 19346325 | Yes |
| 358 | 12334 | 4111.3 | 465.28 | 155.1 | HISAT: a fast spliced aligner with low memory requirements. | Daehwan Kim, Ben Langmead, Steven L Salzberg | Nat Methods | 2015 | 25751142 | Yes |
| 359 | 4095 | 4095.0 | 128.33 | 128.3 | Bacterial evolution. | C R Woese | Microbiol Rev | 1987 | 2439888 | No |
| 360 | 4090 | 4090.0 | 174.69 | 174.7 | A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. | E Pfeiffer | J Am Geriatr Soc | 1975 | 1159263 | Yes |
| 361 | 4084 | 4084.0 | 84.77 | 84.8 | The green fluorescent protein. | R Y Tsien | Annu Rev Biochem | 1998 | 9759496 | No |
| 362 | 8150 | 4075.0 | 208.64 | 104.3 | tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. | T M Lowe, S R Eddy | Nucleic Acids Res | 1997 | 9023104 | Yes |
| 363 | 4056 | 4056.0 | 101.7 | 101.7 | The Scree Test For The Number Of Factors. | R B Cattell | Multivariate Behav Res | 1966 | 26828106 | Yes |
| 364 | 4043 | 4043.0 | 127.12 | 127.1 | How do you feel--now? The anterior insula and human awareness. | A D Bud Craig | Nat Rev Neurosci | 2009 | 19096369 | No |
| 365 | 4042 | 4042.0 | 79.12 | 79.1 | Hypoxia--a key regulatory factor in tumour growth. | Adrian L Harris | Nat Rev Cancer | 2002 | 11902584 | No |
| 366 | 4036 | 4036.0 | 136.18 | 136.2 | Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. | J Cohen | Psychol Bull | 1968 | 19673146 | Yes |
| 367 | 12095 | 4031.7 | 617.54 | 205.8 | Cancer Statistics, 2017. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2017 | 28055103 | Yes |
| 368 | 4027 | 4027.0 | 109.38 | 109.4 | Mesenchymal stem cells. | A I Caplan | J Orthop Res | 1991 | 1870029 | Yes |
| 369 | 8041 | 4020.5 | 222.75 | 111.4 | Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. | S Duval, R Tweedie | Biometrics | 2000 | 10877304 | Yes |
| 370 | 4003 | 4003.0 | 103.49 | 103.5 | Integrins: a family of cell surface receptors. | R O Hynes | Cell | 1987 | 3028640 | No |
| 371 | 3995 | 3995.0 | 70.08 | 70.1 | Principles that govern the folding of protein chains. | C B Anfinsen | Science | 1973 | 4124164 | Yes |
| 372 | 15966 | 3991.5 | 580.67 | 145.2 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | BMJ | 2009 | 19622551 | No |
| 373 | 3989 | 3989.0 | 107.12 | 107.1 | What is the evidence that tumors are angiogenesis dependent? | J Folkman | J Natl Cancer Inst | 1990 | 1688381 | No |
| 374 | 3973 | 3973.0 | 115.9 | 115.9 | Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. | D Vanderbilt | Phys Rev B Condens Matter | 1990 | 9993096 | Yes |
| 375 | 3972 | 3972.0 | 128.33 | 128.3 | Tissue destruction by neutrophils. | S J Weiss | N Engl J Med | 1989 | 2536474 | No |
| 376 | 3971 | 3971.0 | 97.44 | 97.4 | Multiple sequence alignment with hierarchical clustering. | F Corpet | Nucleic Acids Res | 1988 | 2849754 | Yes |
| 377 | 3971 | 3971.0 | 100.43 | 100.4 | Oxidative stress, antioxidants and stress tolerance. | Ron Mittler | Trends Plant Sci | 2002 | 12234732 | No |
| 378 | 11900 | 3966.7 | 303.96 | 101.3 | Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. | W H Habig, M J Pabst, W B Jakoby | J Biol Chem | 1974 | 4436300 | Yes |
| 379 | 3965 | 3965.0 | 0.0 | 0.0 | Staining of tissue sections for electron microscopy with heavy metals. | M L Watson | J Biophys Biochem Cytol | 1958 | 13563554 | Yes |
| 380 | 7923 | 3961.5 | 149.7 | 74.8 | A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. | R S Sikorski, P Hieter | Genetics | 1989 | 2659436 | Yes |
| 381 | 7873 | 3936.5 | 193.51 | 96.8 | Fast and accurate long-read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2010 | 20080505 | Yes |
| 382 | 7865 | 3932.5 | 200.02 | 100.0 | Control of goal-directed and stimulus-driven attention in the brain. | Maurizio Corbetta, Gordon L Shulman | Nat Rev Neurosci | 2002 | 11994752 | No |
| 383 | 3931 | 3931.0 | 104.51 | 104.5 | Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. | R B D'Agostino | Stat Med | 1998 | 9802183 | Yes |
| 384 | 3926 | 3926.0 | 85.32 | 85.3 | Folding DNA to create nanoscale shapes and patterns. | Paul W K Rothemund | Nature | 2006 | 16541064 | Yes |
| 385 | 7846 | 3923.0 | 219.14 | 109.6 | Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. | H Aviv, P Leder | Proc Natl Acad Sci U S A | 1972 | 4504350 | Yes |
| 386 | 3920 | 3920.0 | 103.93 | 103.9 | Observational study of behavior: sampling methods. | J Altmann | Behaviour | 1974 | 4597405 | No |
| 387 | 3911 | 3911.0 | 151.58 | 151.6 | Disc Electrophoresis. I. Background And Theory. | L Ornstein | Ann N Y Acad Sci | 1964 | 14240533 | Yes |
| 388 | 3909 | 3909.0 | 84.01 | 84.0 | Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. | Rakesh K Jain | Science | 2005 | 15637262 | No |
| 389 | 3907 | 3907.0 | 120.48 | 120.5 | Nitric oxide as a secretory product of mammalian cells. | C Nathan | FASEB J | 1992 | 1381691 | No |
| 390 | 11713 | 3904.3 | 315.35 | 105.1 | Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. | J F Kerr, A H Wyllie, A R Currie | Br J Cancer | 1972 | 4561027 | No |
| 391 | 3892 | 3892.0 | 102.78 | 102.8 | Drug combination studies and their synergy quantification using the Chou-Talalay method. | Ting-Chao Chou | Cancer Res | 2010 | 20068163 | Yes |
| 392 | 3889 | 3889.0 | 80.38 | 80.4 | Protein secondary structure prediction based on position-specific scoring matrices. | D T Jones | J Mol Biol | 1999 | 10493868 | Yes |
| 393 | 19429 | 3885.8 | 755.33 | 151.1 | The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. | D J Buysse, C F Reynolds, T H Monk, S R Berman, D J Kupfer | Psychiatry Res | 1989 | 2748771 | Yes |
| 394 | 3883 | 3883.0 | 109.74 | 109.7 | Functions of DNA methylation: islands, start sites, gene bodies and beyond. | Peter A Jones | Nat Rev Genet | 2012 | 22641018 | No |
| 395 | 7765 | 3882.5 | 146.69 | 73.3 | Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. | A H Brand, N Perrimon | Development | 1993 | 8223268 | Yes |
| 396 | 3878 | 3878.0 | 119.3 | 119.3 | Pharmacological implications of microsomal enzyme induction. | A H Conney | Pharmacol Rev | 1967 | 4383307 | Yes |
| 397 | 7756 | 3878.0 | 258.46 | 129.2 | FLASH: fast length adjustment of short reads to improve genome assemblies. | Tanja Magoč, Steven L Salzberg | Bioinformatics | 2011 | 21903629 | Yes |
| 398 | 15477 | 3869.2 | 360.0 | 90.0 | Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. | Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg | Genome Biol | 2009 | 19261174 | Yes |
| 399 | 3863 | 3863.0 | 128.26 | 128.3 | Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. | Russell A Barkley | Psychol Bull | 1997 | 9000892 | No |
| 400 | 3851 | 3851.0 | 128.22 | 128.2 | Preparation of isolated rat liver cells. | P O Seglen | Methods Cell Biol | 1976 | 177845 | No |
| 401 | 3843 | 3843.0 | 98.07 | 98.1 | Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? | Kim A Brogden | Nat Rev Microbiol | 2005 | 15703760 | No |
| 402 | 3839 | 3839.0 | 94.5 | 94.5 | Origin and physiological roles of inflammation. | Ruslan Medzhitov | Nature | 2008 | 18650913 | No |
| 403 | 3831 | 3831.0 | 95.79 | 95.8 | The origins and the future of microfluidics. | George M Whitesides | Nature | 2006 | 16871203 | No |
| 404 | 3830 | 3830.0 | 101.64 | 101.6 | A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. | Heng Li | Bioinformatics | 2011 | 21903627 | Yes |
| 405 | 7647 | 3823.5 | 305.23 | 152.6 | The qualitative content analysis process. | Satu Elo, Helvi Kyngäs | J Adv Nurs | 2008 | 18352969 | Yes |
| 406 | 3819 | 3819.0 | 96.62 | 96.6 | Sequencing technologies - the next generation. | Michael L Metzker | Nat Rev Genet | 2010 | 19997069 | No |
| 407 | 3818 | 3818.0 | 90.85 | 90.8 | Caspases: the executioners of apoptosis. | G M Cohen | Biochem J | 1997 | 9337844 | No |
| 408 | 3812 | 3812.0 | 103.21 | 103.2 | Revisions in the International System for Staging Lung Cancer. | C F Mountain | Chest | 1997 | 9187198 | Yes |
| 409 | 3809 | 3809.0 | 84.59 | 84.6 | Instability and decay of the primary structure of DNA. | T Lindahl | Nature | 1993 | 8469282 | No |
| 410 | 3802 | 3802.0 | 110.1 | 110.1 | Accelerated Profile HMM Searches. | Sean R Eddy | PLoS Comput Biol | 2011 | 22039361 | Yes |
| 411 | 3800 | 3800.0 | 74.07 | 74.1 | Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. | G R Martin | Proc Natl Acad Sci U S A | 1981 | 6950406 | Yes |
| 412 | 3800 | 3800.0 | 80.81 | 80.8 | Scaling and assessment of data quality. | Philip Evans | Acta Crystallogr D Biol Crystallogr | 2006 | 16369096 | No |
| 413 | 7590 | 3795.0 | 167.75 | 83.9 | Inference of macromolecular assemblies from crystalline state. | Evgeny Krissinel, Kim Henrick | J Mol Biol | 2007 | 17681537 | Yes |
| 414 | 3792 | 3792.0 | 80.31 | 80.3 | A catalogue of splice junction sequences. | S M Mount | Nucleic Acids Res | 1982 | 7063411 | Yes |
| 415 | 3784 | 3784.0 | 126.86 | 126.9 | Generalized expectancies for internal versus external control of reinforcement. | J B Rotter | Psychol Monogr | 1966 | 5340840 | No |
| 416 | 15108 | 3777.0 | 483.65 | 120.9 | A brief measure for assessing generalized anxiety disorder: the GAD-7. | Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd Löwe | Arch Intern Med | 2006 | 16717171 | Yes |
| 417 | 3769 | 3769.0 | 119.05 | 119.0 | genepop'007: a complete re-implementation of the genepop software for Windows and Linux. | François Rousset | Mol Ecol Resour | 2008 | 21585727 | Yes |
| 418 | 3764 | 3764.0 | 87.22 | 87.2 | Novel proteinaceous infectious particles cause scrapie. | S B Prusiner | Science | 1982 | 6801762 | Yes |
| 419 | 3764 | 3764.0 | 77.43 | 77.4 | TGF-beta signal transduction. | J Massagué | Annu Rev Biochem | 1998 | 9759503 | No |
| 420 | 7528 | 3764.0 | 209.04 | 104.5 | BEAST: Bayesian evolutionary analysis by sampling trees. | Alexei J Drummond, Andrew Rambaut | BMC Evol Biol | 2007 | 17996036 | Yes |
| 421 | 7522 | 3761.0 | 181.22 | 90.6 | Mitochondria and apoptosis. | D R Green, J C Reed | Science | 1998 | 9721092 | No |
| 422 | 7522 | 3761.0 | 189.54 | 94.8 | The basics of epithelial-mesenchymal transition. | Raghu Kalluri, Robert A Weinberg | J Clin Invest | 2009 | 19487818 | No |
| 423 | 3760 | 3760.0 | 108.81 | 108.8 | What's wrong with Bonferroni adjustments. | T V Perneger | BMJ | 1998 | 9553006 | No |
| 424 | 3757 | 3757.0 | 154.6 | 154.6 | Estimation of the molecular weights of proteins by Sephadex gel-filtration. | P Andrews | Biochem J | 1964 | 4158310 | Yes |
| 425 | 3755 | 3755.0 | 107.9 | 107.9 | Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. | Peter C Austin | Stat Med | 2009 | 19757444 | Yes |
| 426 | 7495 | 3747.5 | 180.15 | 90.1 | The plant immune system. | Jonathan D G Jones, Jeffery L Dangl | Nature | 2006 | 17108957 | No |
| 427 | 3745 | 3745.0 | 107.1 | 107.1 | Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. | J H Morrissey | Anal Biochem | 1981 | 6172996 | Yes |
| 428 | 3745 | 3745.0 | 89.08 | 89.1 | Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. | A T Brünger | Nature | 1992 | 18481394 | Yes |
| 429 | 11225 | 3741.7 | 215.19 | 71.7 | Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. | J D Dignam, R M Lebovitz, R G Roeder | Nucleic Acids Res | 1983 | 6828386 | Yes |
| 430 | 3735 | 3735.0 | 169.62 | 169.6 | Basic principles of ROC analysis. | C E Metz | Semin Nucl Med | 1978 | 112681 | Yes |
| 431 | 3732 | 3732.0 | 115.67 | 115.7 | DNA methylation age of human tissues and cell types. | Steve Horvath | Genome Biol | 2013 | 24138928 | Yes |
| 432 | 14891 | 3722.8 | 383.76 | 95.9 | Global cancer statistics, 2002. | D Max Parkin, Freddie Bray, J Ferlay, Paola Pisani | CA Cancer J Clin | 2005 | 15761078 | Yes |
| 433 | 3703 | 3703.0 | 61.47 | 61.5 | A membrane-filter technique for the detection of complementary DNA. | D T Denhardt | Biochem Biophys Res Commun | 1966 | 5963888 | Yes |
| 434 | 3703 | 3703.0 | 93.66 | 93.7 | RELION: implementation of a Bayesian approach to cryo-EM structure determination. | Sjors H W Scheres | J Struct Biol | 2012 | 23000701 | Yes |
| 435 | 7404 | 3702.0 | 253.95 | 127.0 | Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. | Laurent Excoffier, Heidi E L Lischer | Mol Ecol Resour | 2010 | 21565059 | Yes |
| 436 | 3684 | 3684.0 | 66.21 | 66.2 | Somatic generation of antibody diversity. | S Tonegawa | Nature | 1983 | 6300689 | No |
| 437 | 3682 | 3682.0 | 106.02 | 106.0 | Protective and damaging effects of stress mediators. | B S McEwen | N Engl J Med | 1998 | 9428819 | No |
| 438 | 7356 | 3678.0 | 184.47 | 92.2 | An integrative theory of prefrontal cortex function. | E K Miller, J D Cohen | Annu Rev Neurosci | 2001 | 11283309 | No |
| 439 | 3677 | 3677.0 | 85.79 | 85.8 | Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. | Ting-Chao Chou | Pharmacol Rev | 2006 | 16968952 | No |
| 440 | 7345 | 3672.5 | 161.64 | 80.8 | Functional rafts in cell membranes. | K Simons, E Ikonen | Nature | 1997 | 9177342 | No |
| 441 | 3671 | 3671.0 | 88.83 | 88.8 | I-TASSER server for protein 3D structure prediction. | Yang Zhang | BMC Bioinformatics | 2008 | 18215316 | Yes |
| 442 | 3669 | 3669.0 | 103.23 | 103.2 | Graphene: status and prospects. | A K Geim | Science | 2009 | 19541989 | Yes |
| 443 | 3668 | 3668.0 | 103.22 | 103.2 | EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. | W Klimesch | Brain Res Brain Res Rev | 1999 | 10209231 | No |
| 444 | 3640 | 3640.0 | 100.78 | 100.8 | Biological roles of oligosaccharides: all of the theories are correct. | A Varki | Glycobiology | 1993 | 8490246 | No |
| 445 | 3640 | 3640.0 | 94.83 | 94.8 | The adolescent brain and age-related behavioral manifestations. | L P Spear | Neurosci Biobehav Rev | 2000 | 10817843 | No |
| 446 | 7234 | 3617.0 | 183.22 | 91.6 | The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. | R C Graham, M J Karnovsky | J Histochem Cytochem | 1966 | 5962951 | Yes |
| 447 | 21663 | 3610.5 | 975.7 | 162.6 | Global cancer statistics, 2012. | Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin Jemal | CA Cancer J Clin | 2015 | 25651787 | Yes |
| 448 | 3601 | 3601.0 | 108.02 | 108.0 | Inositol trisphosphate and diacylglycerol as second messengers. | M J Berridge | Biochem J | 1984 | 6146314 | No |
| 449 | 3598 | 3598.0 | 84.62 | 84.6 | Marrow stromal cells as stem cells for nonhematopoietic tissues. | D J Prockop | Science | 1997 | 9082988 | No |
| 450 | 7155 | 3577.5 | 180.69 | 90.3 | Long short-term memory. | S Hochreiter, J Schmidhuber | Neural Comput | 1997 | 9377276 | Yes |
| 451 | 3576 | 3576.0 | 74.76 | 74.8 | Profile hidden Markov models. | S R Eddy | Bioinformatics | 1998 | 9918945 | No |
| 452 | 10716 | 3572.0 | 258.63 | 86.2 | Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nucleic Acids Res | 2009 | 19033363 | Yes |
| 453 | 3557 | 3557.0 | 108.92 | 108.9 | Health promotion by social cognitive means. | Albert Bandura | Health Educ Behav | 2004 | 15090118 | Yes |
| 454 | 3550 | 3550.0 | 97.02 | 97.0 | Non-coding RNAs in human disease. | Manel Esteller | Nat Rev Genet | 2011 | 22094949 | No |
| 455 | 3545 | 3545.0 | 84.58 | 84.6 | Neural networks and physical systems with emergent collective computational abilities. | J J Hopfield | Proc Natl Acad Sci U S A | 1982 | 6953413 | Yes |
| 456 | 3540 | 3540.0 | 70.68 | 70.7 | Mammalian neural stem cells. | F H Gage | Science | 2000 | 10688783 | No |
| 457 | 3537 | 3537.0 | 164.12 | 164.1 | Estimation of average heterozygosity and genetic distance from a small number of individuals. | M Nei | Genetics | 1978 | 17248844 | Yes |
| 458 | 17633 | 3526.6 | 1202.77 | 240.6 | MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. | Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro Tamura | Mol Biol Evol | 2018 | 29722887 | Yes |
| 459 | 3526 | 3526.0 | 80.0 | 80.0 | Nonalcoholic fatty liver disease. | Paul Angulo | N Engl J Med | 2002 | 11961152 | No |
| 460 | 3525 | 3525.0 | 109.37 | 109.4 | Psychometric properties of the strengths and difficulties questionnaire. | R Goodman | J Am Acad Child Adolesc Psychiatry | 2001 | 11699809 | Yes |
| 461 | 3522 | 3522.0 | 66.7 | 66.7 | Signal transduction by the JNK group of MAP kinases. | R J Davis | Cell | 2000 | 11057897 | No |
| 462 | 7044 | 3522.0 | 126.91 | 63.5 | Translating the histone code. | T Jenuwein, C D Allis | Science | 2001 | 11498575 | No |
| 463 | 3516 | 3516.0 | 54.17 | 54.2 | Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. | J D Rowley | Nature | 1973 | 4126434 | Yes |
| 464 | 10541 | 3513.7 | 259.22 | 86.4 | Understanding the Warburg effect: the metabolic requirements of cell proliferation. | Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson | Science | 2009 | 19460998 | No |
| 465 | 7025 | 3512.5 | 146.12 | 73.1 | A new method for sequencing DNA. | A M Maxam, W Gilbert | Proc Natl Acad Sci U S A | 1977 | 265521 | Yes |
| 466 | 3511 | 3511.0 | 113.04 | 113.0 | Modeling valuations for EuroQol health states. | P Dolan | Med Care | 1997 | 9366889 | Yes |
| 467 | 7020 | 3510.0 | 359.0 | 179.5 | Microsomal lipid peroxidation. | J A Buege, S D Aust | Methods Enzymol | 1978 | 672633 | Yes |
| 468 | 3509 | 3509.0 | 104.73 | 104.7 | Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. | L R Squire | Psychol Rev | 1992 | 1594723 | No |
| 469 | 3508 | 3508.0 | 80.02 | 80.0 | Glutamate uptake. | N C Danbolt | Prog Neurobiol | 2001 | 11369436 | No |
| 470 | 7014 | 3507.0 | 83.26 | 41.6 | Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. | D H Hubel, T N Wiesel | J Physiol | 1962 | 14449617 | Yes |
| 471 | 17530 | 3506.0 | 495.3 | 99.1 | Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. | O P Hamill, A Marty, E Neher, B Sakmann, F J Sigworth | Pflugers Arch | 1981 | 6270629 | Yes |
| 472 | 3503 | 3503.0 | 90.95 | 91.0 | Microglia: a sensor for pathological events in the CNS. | G W Kreutzberg | Trends Neurosci | 1996 | 8843599 | No |
| 473 | 3499 | 3499.0 | 54.96 | 55.0 | Spectroscopic determination of tryptophan and tyrosine in proteins. | H Edelhoch | Biochemistry | 1967 | 6049437 | Yes |
| 474 | 3491 | 3491.0 | 86.28 | 86.3 | How do you feel? Interoception: the sense of the physiological condition of the body. | A D Craig | Nat Rev Neurosci | 2002 | 12154366 | No |
| 475 | 3490 | 3490.0 | 128.39 | 128.4 | You want to measure coping but your protocol's too long: consider the brief COPE. | C S Carver | Int J Behav Med | 1997 | 16250744 | Yes |
| 476 | 3488 | 3488.0 | 58.9 | 58.9 | Statistical estimations in enzyme kinetics. | G N Wilkinson | Biochem J | 1961 | 13785321 | Yes |
| 477 | 3487 | 3487.0 | 0.0 | 0.0 | The magical number seven plus or minus two: some limits on our capacity for processing information. | G A Miller | Psychol Rev | 1956 | 13310704 | Yes |
| 478 | 3477 | 3477.0 | 51.93 | 51.9 | The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. | J F Woessner | Arch Biochem Biophys | 1961 | 13786180 | Yes |
| 479 | 3476 | 3476.0 | 84.78 | 84.8 | The heat-shock response. | S Lindquist | Annu Rev Biochem | 1986 | 2427013 | No |
| 480 | 10418 | 3472.7 | 392.26 | 130.8 | Cancer statistics, 2013. | Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal | CA Cancer J Clin | 2013 | 23335087 | Yes |
| 481 | 3472 | 3472.0 | 80.84 | 80.8 | The dendritic cell system and its role in immunogenicity. | R M Steinman | Annu Rev Immunol | 1991 | 1910679 | No |
| 482 | 3469 | 3469.0 | 86.38 | 86.4 | The pathobiology of diabetic complications: a unifying mechanism. | Michael Brownlee | Diabetes | 2005 | 15919781 | No |
| 483 | 3457 | 3457.0 | 135.01 | 135.0 | Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. | O W Griffith | Anal Biochem | 1980 | 7416462 | Yes |
| 484 | 3454 | 3454.0 | 154.88 | 154.9 | The quality of care. How can it be assessed? | A Donabedian | JAMA | 1988 | 3045356 | No |
| 485 | 3449 | 3449.0 | 93.77 | 93.8 | Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. | R W Mahley | Science | 1988 | 3283935 | No |
| 486 | 3442 | 3442.0 | 74.6 | 74.6 | Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. | H F Dvorak | N Engl J Med | 1986 | 3537791 | No |
| 487 | 3439 | 3439.0 | 86.73 | 86.7 | Biologic basis for interleukin-1 in disease. | C A Dinarello | Blood | 1996 | 8630372 | No |
| 488 | 6875 | 3437.5 | 135.41 | 67.7 | Statistical significance for genomewide studies. | John D Storey, Robert Tibshirani | Proc Natl Acad Sci U S A | 2003 | 12883005 | Yes |
| 489 | 6872 | 3436.0 | 162.73 | 81.4 | "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. | A P Feinberg, B Vogelstein | Anal Biochem | 1984 | 6329026 | Yes |
| 490 | 10278 | 3426.0 | 449.88 | 150.0 | Cancer statistics, 2015. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2015 | 25559415 | Yes |
| 491 | 3425 | 3425.0 | 109.67 | 109.7 | No adjustments are needed for multiple comparisons. | K J Rothman | Epidemiology | 1990 | 2081237 | Yes |
| 492 | 3421 | 3421.0 | 101.65 | 101.7 | adegenet: a R package for the multivariate analysis of genetic markers. | Thibaut Jombart | Bioinformatics | 2008 | 18397895 | Yes |
| 493 | 3416 | 3416.0 | 59.98 | 60.0 | Automated electron microscope tomography using robust prediction of specimen movements. | David N Mastronarde | J Struct Biol | 2005 | 16182563 | Yes |
| 494 | 6799 | 3399.5 | 172.64 | 86.3 | TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. | T R Mosmann, R L Coffman | Annu Rev Immunol | 1989 | 2523712 | No |
| 495 | 3388 | 3388.0 | 0.0 | 0.0 | Some factors in the interpretation of protein denaturation. | W Kauzmann | Adv Protein Chem | 1959 | 14404936 | Yes |
| 496 | 6764 | 3382.0 | 185.11 | 92.6 | Velvet: algorithms for de novo short read assembly using de Bruijn graphs. | Daniel R Zerbino, Ewan Birney | Genome Res | 2008 | 18349386 | Yes |
| 497 | 3380 | 3380.0 | 82.46 | 82.5 | The basis of anisotropic water diffusion in the nervous system - a technical review. | Christian Beaulieu | NMR Biomed | 2002 | 12489094 | No |
| 498 | 10139 | 3379.7 | 98.26 | 32.8 | The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. | F C Greenwood, W M Hunter, J S Glover | Biochem J | 1963 | 14097352 | Yes |
| 499 | 10109 | 3369.7 | 358.86 | 119.6 | Cancer statistics, 2012. | Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal | CA Cancer J Clin | 2012 | 22237781 | Yes |
| 500 | 6729 | 3364.5 | 159.06 | 79.5 | Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. | C Tuerk, L Gold | Science | 1990 | 2200121 | Yes |
| 501 | 6727 | 3363.5 | 128.64 | 64.3 | The ubiquitin system. | A Hershko, A Ciechanover | Annu Rev Biochem | 1998 | 9759494 | No |
| 502 | 6722 | 3361.0 | 207.37 | 103.7 | The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. | Stephen B Edge, Carolyn C Compton | Ann Surg Oncol | 2010 | 20180029 | No |
| 503 | 3359 | 3359.0 | 76.44 | 76.4 | Tolerance, danger, and the extended family. | P Matzinger | Annu Rev Immunol | 1994 | 8011301 | No |
| 504 | 3355 | 3355.0 | 94.72 | 94.7 | Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. | Thomas Welton | Chem Rev | 1999 | 11849019 | Yes |
| 505 | 3351 | 3351.0 | 68.64 | 68.6 | The scanning model for translation: an update. | M Kozak | J Cell Biol | 1989 | 2645293 | No |
| 506 | 6670 | 3335.0 | 141.99 | 71.0 | Angiogenesis in cancer and other diseases. | P Carmeliet, R K Jain | Nature | 2000 | 11001068 | No |
| 507 | 3327 | 3327.0 | 68.05 | 68.0 | Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. | M Kozak | Nucleic Acids Res | 1984 | 6694911 | Yes |
| 508 | 3327 | 3327.0 | 532.39 | 532.4 | Hallmarks of Cancer: New Dimensions. | Douglas Hanahan | Cancer Discov | 2022 | 35022204 | No |
| 509 | 3312 | 3312.0 | 79.94 | 79.9 | Wound healing--aiming for perfect skin regeneration. | P Martin | Science | 1997 | 9082989 | No |
| 510 | 3302 | 3302.0 | 83.86 | 83.9 | Gene regulation by steroid hormones. | M Beato | Cell | 1989 | 2644044 | No |
| 511 | 3300 | 3300.0 | 110.67 | 110.7 | Equilibrium Ultracentrifugation Of Dilute Solutions. | D A Yphantis | Biochemistry | 1964 | 14155091 | Yes |
| 512 | 3294 | 3294.0 | 89.02 | 89.0 | Hay fever, hygiene, and household size. | D P Strachan | BMJ | 1989 | 2513902 | Yes |
| 513 | 6581 | 3290.5 | 157.68 | 78.8 | Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. | Weizhong Li, Adam Godzik | Bioinformatics | 2006 | 16731699 | Yes |
| 514 | 3290 | 3290.0 | 64.14 | 64.1 | The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. | Isaiah J Fidler | Nat Rev Cancer | 2003 | 12778135 | No |
| 515 | 6574 | 3287.0 | 211.97 | 106.0 | Human malaria parasites in continuous culture. | W Trager, J B Jensen | Science | 1976 | 781840 | Yes |
| 516 | 6550 | 3275.0 | 178.29 | 89.1 | Projections of global mortality and burden of disease from 2002 to 2030. | Colin D Mathers, Dejan Loncar | PLoS Med | 2006 | 17132052 | Yes |
| 517 | 6549 | 3274.5 | 204.42 | 102.2 | Complex network measures of brain connectivity: uses and interpretations. | Mikail Rubinov, Olaf Sporns | Neuroimage | 2010 | 19819337 | Yes |
| 518 | 3272 | 3272.0 | 66.79 | 66.8 | Alzheimer's disease is a synaptic failure. | Dennis J Selkoe | Science | 2002 | 12399581 | No |
| 519 | 6544 | 3272.0 | 217.08 | 108.5 | Management of hepatocellular carcinoma: an update. | Jordi Bruix, Morris Sherman | Hepatology | 2011 | 21374666 | No |
| 520 | 3270 | 3270.0 | 60.05 | 60.0 | Cell signaling by receptor tyrosine kinases. | J Schlessinger | Cell | 2000 | 11057895 | No |
| 521 | 3265 | 3265.0 | 86.83 | 86.8 | ABC transporters: from microorganisms to man. | C F Higgins | Annu Rev Cell Biol | 1992 | 1282354 | No |
| 522 | 3257 | 3257.0 | 109.86 | 109.9 | Transformed up-down methods in psychoacoustics. | H Levitt | J Acoust Soc Am | 1971 | 5541744 | Yes |
| 523 | 13024 | 3256.0 | 301.39 | 75.3 | Improved methods for building protein models in electron density maps and the location of errors in these models. | T A Jones, J Y Zou, S W Cowan, M Kjeldgaard | Acta Crystallogr A | 1991 | 2025413 | Yes |
| 524 | 3255 | 3255.0 | 76.35 | 76.3 | Photoelectrochemical cells. | M Grätzel | Nature | 2001 | 11713540 | Yes |
| 525 | 3254 | 3254.0 | 73.76 | 73.8 | Mitochondrial formation of reactive oxygen species. | Julio F Turrens | J Physiol | 2003 | 14561818 | No |
| 526 | 6497 | 3248.5 | 195.68 | 97.8 | Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. | C Beauchamp, I Fridovich | Anal Biochem | 1971 | 4943714 | Yes |
| 527 | 3239 | 3239.0 | 93.58 | 93.6 | Inositol trisphosphate and diacylglycerol: two interacting second messengers. | M J Berridge | Annu Rev Biochem | 1987 | 3304132 | No |
| 528 | 3236 | 3236.0 | 64.02 | 64.0 | STATs and gene regulation. | J E Darnell | Science | 1997 | 9287210 | No |
| 529 | 3235 | 3235.0 | 103.53 | 103.5 | Essential oils: their antibacterial properties and potential applications in foods--a review. | Sara Burt | Int J Food Microbiol | 2004 | 15246235 | No |
| 530 | 3232 | 3232.0 | 98.1 | 98.1 | Development of a classification system for periodontal diseases and conditions. | G C Armitage | Ann Periodontol | 1999 | 10863370 | No |
| 531 | 3228 | 3228.0 | 115.69 | 115.7 | Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. | Joseph P Weir | J Strength Cond Res | 2005 | 15705040 | No |
| 532 | 3227 | 3227.0 | 69.39 | 69.4 | Activators and target genes of Rel/NF-kappaB transcription factors. | H L Pahl | Oncogene | 1999 | 10602461 | No |
| 533 | 3219 | 3219.0 | 67.57 | 67.6 | Cardiac excitation-contraction coupling. | Donald M Bers | Nature | 2002 | 11805843 | No |
| 534 | 3218 | 3218.0 | 84.33 | 84.3 | Accurate Coulomb-fitting basis sets for H to Rn. | Florian Weigend | Phys Chem Chem Phys | 2006 | 16633586 | Yes |
| 535 | 28942 | 3215.8 | 621.97 | 69.1 | Cytoscape: a software environment for integrated models of biomolecular interaction networks. | Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey Ideker | Genome Res | 2003 | 14597658 | Yes |
| 536 | 3203 | 3203.0 | 65.24 | 65.2 | CpG-rich islands and the function of DNA methylation. | A P Bird | Nature | 1986 | 2423876 | No |
| 537 | 3191 | 3191.0 | 66.33 | 66.3 | Protein folding and misfolding. | Christopher M Dobson | Nature | 2003 | 14685248 | No |
| 538 | 6368 | 3184.0 | 153.62 | 76.8 | Exploring the full spectrum of macrophage activation. | David M Mosser, Justin P Edwards | Nat Rev Immunol | 2008 | 19029990 | No |
| 539 | 6362 | 3181.0 | 198.67 | 99.3 | Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. | K Tamura, M Nei | Mol Biol Evol | 1993 | 8336541 | Yes |
| 540 | 3172 | 3172.0 | 110.02 | 110.0 | The Danish Civil Registration System. | Carsten Bøcker Pedersen | Scand J Public Health | 2011 | 21775345 | Yes |
| 541 | 3166 | 3166.0 | 78.3 | 78.3 | The transforming growth factor-beta family. | J Massagué | Annu Rev Cell Biol | 1990 | 2177343 | No |
| 542 | 6332 | 3166.0 | 184.5 | 92.2 | Complex brain networks: graph theoretical analysis of structural and functional systems. | Ed Bullmore, Olaf Sporns | Nat Rev Neurosci | 2009 | 19190637 | No |
| 543 | 6317 | 3158.5 | 133.09 | 66.5 | Toll-like receptor signalling. | Shizuo Akira, Kiyoshi Takeda | Nat Rev Immunol | 2004 | 15229469 | No |
| 544 | 3156 | 3156.0 | 90.85 | 90.8 | Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. | Y X Fu | Genetics | 1997 | 9335623 | Yes |
| 545 | 12618 | 3154.5 | 477.73 | 119.4 | APACHE II: a severity of disease classification system. | W A Knaus, E A Draper, D P Wagner, J E Zimmerman | Crit Care Med | 1985 | 3928249 | Yes |
| 546 | 3153 | 3153.0 | 96.73 | 96.7 | Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. | Sarah E Barlow | Pediatrics | 2007 | 18055651 | Yes |
| 547 | 6290 | 3145.0 | 206.49 | 103.2 | Measuring agreement in method comparison studies. | J M Bland, D G Altman | Stat Methods Med Res | 1999 | 10501650 | No |
| 548 | 9429 | 3143.0 | 229.62 | 76.5 | ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. | Kai Wang, Mingyao Li, Hakon Hakonarson | Nucleic Acids Res | 2010 | 20601685 | Yes |
| 549 | 9422 | 3140.7 | 266.14 | 88.7 | Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. | G Evanno, S Regnaut, J Goudet | Mol Ecol | 2005 | 15969739 | Yes |
| 550 | 6279 | 3139.5 | 101.92 | 51.0 | Pain mechanisms: a new theory. | R Melzack, P D Wall | Science | 1965 | 5320816 | No |
| 551 | 3139 | 3139.0 | 0.0 | 0.0 | Diffusion-in-gel methods for immunological analysis. | O Ouchterlony | Prog Allergy | 1958 | 13578996 | Yes |
| 552 | 3138 | 3138.0 | 74.05 | 74.0 | WHAT IF: a molecular modeling and drug design program. | G Vriend | J Mol Graph | 1990 | 2268628 | Yes |
| 553 | 3136 | 3136.0 | 84.5 | 84.5 | The nuclear factor NF-kappaB pathway in inflammation. | Toby Lawrence | Cold Spring Harb Perspect Biol | 2009 | 20457564 | No |
| 554 | 3133 | 3133.0 | 78.07 | 78.1 | Cellular and molecular mechanisms of fibrosis. | T A Wynn | J Pathol | 2008 | 18161745 | No |
| 555 | 3132 | 3132.0 | 65.74 | 65.7 | Angiogenesis in health and disease. | Peter Carmeliet | Nat Med | 2003 | 12778163 | No |
| 556 | 6263 | 3131.5 | 152.14 | 76.1 | In vitro selection of RNA molecules that bind specific ligands. | A D Ellington, J W Szostak | Nature | 1990 | 1697402 | Yes |
| 557 | 3131 | 3131.0 | 121.54 | 121.5 | Half a century of research on the Stroop effect: an integrative review. | C M MacLeod | Psychol Bull | 1991 | 2034749 | No |
| 558 | 3131 | 3131.0 | 26.75 | 26.8 | Gene action in the X-chromosome of the mouse (Mus musculus L.). | M F Lyon | Nature | 1961 | 13764598 | Yes |
| 559 | 6261 | 3130.5 | 53.82 | 26.9 | The serial cultivation of human diploid cell strains. | L Hayflick, P S Moorhead | Exp Cell Res | 1961 | 13905658 | Yes |
| 560 | 3128 | 3128.0 | 65.88 | 65.9 | Mechanisms of angiogenesis and arteriogenesis. | P Carmeliet | Nat Med | 2000 | 10742145 | No |
| 561 | 12506 | 3126.5 | 455.5 | 113.9 | Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. | Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg Lang | Behav Res Methods | 2009 | 19897823 | Yes |
| 562 | 9331 | 3110.3 | 194.25 | 64.8 | Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. | Benjamin P Lewis, Christopher B Burge, David P Bartel | Cell | 2005 | 15652477 | Yes |
| 563 | 6220 | 3110.0 | 156.68 | 78.3 | Voxel-based morphometry--the methods. | J Ashburner, K J Friston | Neuroimage | 2000 | 10860804 | No |
| 564 | 3106 | 3106.0 | 115.69 | 115.7 | KDIGO clinical practice guidelines for acute kidney injury. | Arif Khwaja | Nephron Clin Pract | 2012 | 22890468 | No |
| 565 | 6207 | 3103.5 | 266.62 | 133.3 | GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. | Rod Peakall, Peter E Smouse | Bioinformatics | 2012 | 22820204 | Yes |
| 566 | 6201 | 3100.5 | 163.09 | 81.5 | The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. | Taro Kawai, Shizuo Akira | Nat Immunol | 2010 | 20404851 | No |
| 567 | 3098 | 3098.0 | 124.67 | 124.7 | Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. | T E Moffitt | Psychol Rev | 1993 | 8255953 | No |
| 568 | 6192 | 3096.0 | 196.0 | 98.0 | Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. | R M Ryan, E L Deci | Am Psychol | 2000 | 11392867 | Yes |
| 569 | 3095 | 3095.0 | 88.92 | 88.9 | Hepatocellular carcinoma. | Hashem B El-Serag | N Engl J Med | 2011 | 21992124 | No |
| 570 | 9280 | 3093.3 | 311.43 | 103.8 | Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. | R M Palmer, A G Ferrige, S Moncada | Nature | 1987 | 3495737 | Yes |
| 571 | 3091 | 3091.0 | 89.37 | 89.4 | Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). | Gunther Eysenbach | J Med Internet Res | 2004 | 15471760 | No |
| 572 | 3089 | 3089.0 | 75.85 | 75.8 | Recent advances with liposomes as pharmaceutical carriers. | Vladimir P Torchilin | Nat Rev Drug Discov | 2005 | 15688077 | No |
| 573 | 3088 | 3088.0 | 89.1 | 89.1 | Efficient methods to compute genomic predictions. | P M VanRaden | J Dairy Sci | 2008 | 18946147 | Yes |
| 574 | 3086 | 3086.0 | 105.95 | 106.0 | The processing-speed theory of adult age differences in cognition. | T A Salthouse | Psychol Rev | 1996 | 8759042 | No |
| 575 | 6164 | 3082.0 | 108.53 | 54.3 | The language of covalent histone modifications. | B D Strahl, C D Allis | Nature | 2000 | 10638745 | Yes |
| 576 | 3082 | 3082.0 | 72.66 | 72.7 | Obesity as a medical problem. | P G Kopelman | Nature | 2000 | 10766250 | No |
| 577 | 6164 | 3082.0 | 136.36 | 68.2 | MicroRNA signatures in human cancers. | George A Calin, Carlo M Croce | Nat Rev Cancer | 2006 | 17060945 | No |
| 578 | 6149 | 3074.5 | 180.5 | 90.2 | mTOR signaling in growth control and disease. | Mathieu Laplante, David M Sabatini | Cell | 2012 | 22500797 | No |
| 579 | 27631 | 3070.1 | 872.37 | 96.9 | STAR: ultrafast universal RNA-seq aligner. | Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R Gingeras | Bioinformatics | 2013 | 23104886 | Yes |
| 580 | 3069 | 3069.0 | 86.13 | 86.1 | Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. | S W Kessler | J Immunol | 1975 | 1102604 | Yes |
| 581 | 6114 | 3057.0 | 188.01 | 94.0 | Electrochemical photolysis of water at a semiconductor electrode. | A Fujishima, K Honda | Nature | 1972 | 12635268 | Yes |
| 582 | 21393 | 3056.1 | 796.07 | 113.7 | limma powers differential expression analyses for RNA-sequencing and microarray studies. | Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth | Nucleic Acids Res | 2015 | 25605792 | Yes |
| 583 | 3054 | 3054.0 | 65.14 | 65.1 | TGFbeta in Cancer. | Joan Massagué | Cell | 2008 | 18662538 | No |
| 584 | 24430 | 3053.8 | 527.54 | 65.9 | The Protein Data Bank. | H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E Bourne | Nucleic Acids Res | 2000 | 10592235 | Yes |
| 585 | 3051 | 3051.0 | 103.16 | 103.2 | What is value in health care? | Michael E Porter | N Engl J Med | 2010 | 21142528 | Yes |
| 586 | 3049 | 3049.0 | 56.81 | 56.8 | Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. | P Schuck | Biophys J | 2000 | 10692345 | Yes |
| 587 | 3042 | 3042.0 | 70.52 | 70.5 | Cadherin cell adhesion receptors as a morphogenetic regulator. | M Takeichi | Science | 1991 | 2006419 | No |
| 588 | 3037 | 3037.0 | 114.77 | 114.8 | A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. | S Hakomori | J Biochem | 1964 | 14135466 | Yes |
| 589 | 6071 | 3035.5 | 0.0 | 0.0 | A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. | S Reitman, S Frankel | Am J Clin Pathol | 1957 | 13458125 | Yes |
| 590 | 3035 | 3035.0 | 136.63 | 136.6 | The short-form McGill Pain Questionnaire. | Ronald Melzack | Pain | 1987 | 3670870 | Yes |
| 591 | 3031 | 3031.0 | 72.64 | 72.6 | The resurgence of platinum-based cancer chemotherapy. | Lloyd Kelland | Nat Rev Cancer | 2007 | 17625587 | No |
| 592 | 3025 | 3025.0 | 102.73 | 102.7 | Measurement of pain. | E C Huskisson | Lancet | 1974 | 4139420 | Yes |
| 593 | 9059 | 3019.7 | 170.67 | 56.9 | Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. | Ron Edgar, Michael Domrachev, Alex E Lash | Nucleic Acids Res | 2002 | 11752295 | Yes |
| 594 | 6038 | 3019.0 | 143.09 | 71.5 | Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. | T C Chou, P Talalay | Adv Enzyme Regul | 1984 | 6382953 | Yes |
| 595 | 6030 | 3015.0 | 223.83 | 111.9 | The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. | P F Lovibond, S H Lovibond | Behav Res Ther | 1995 | 7726811 | Yes |
| 596 | 12049 | 3012.2 | 284.4 | 71.1 | Haploview: analysis and visualization of LD and haplotype maps. | J C Barrett, B Fry, J Maller, M J Daly | Bioinformatics | 2005 | 15297300 | Yes |
| 597 | 9023 | 3007.7 | 176.93 | 59.0 | Significance analysis of microarrays applied to the ionizing radiation response. | V G Tusher, R Tibshirani, G Chu | Proc Natl Acad Sci U S A | 2001 | 11309499 | Yes |
| 598 | 33083 | 3007.5 | 688.41 | 62.6 | Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. | Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P Mesirov | Proc Natl Acad Sci U S A | 2005 | 16199517 | Yes |
| 599 | 3007 | 3007.0 | 0.0 | 0.0 | A study of fixation for electron microscopy. | G E Palade | J Exp Med | 1952 | 14927794 | Yes |
| 600 | 5983 | 2991.5 | 134.8 | 67.4 | Oxidants, oxidative stress and the biology of ageing. | T Finkel, N J Holbrook | Nature | 2000 | 11089981 | No |
| 601 | 8969 | 2989.7 | 206.38 | 68.8 | TopHat: discovering splice junctions with RNA-Seq. | Cole Trapnell, Lior Pachter, Steven L Salzberg | Bioinformatics | 2009 | 19289445 | Yes |
| 602 | 2984 | 2984.0 | 58.92 | 58.9 | Toll-like receptors and innate immunity. | R Medzhitov | Nat Rev Immunol | 2001 | 11905821 | No |
| 603 | 2983 | 2983.0 | 0.0 | 0.0 | Catheter replacement of the needle in percutaneous arteriography; a new technique. | S I Seldinger | Acta radiol | 1953 | 13057644 | Yes |
| 604 | 2977 | 2977.0 | 73.48 | 73.5 | Optimal two-stage designs for phase II clinical trials. | R Simon | Control Clin Trials | 1989 | 2702835 | Yes |
| 605 | 2976 | 2976.0 | 90.37 | 90.4 | Estimation of metabolite concentrations from localized in vivo proton NMR spectra. | S W Provencher | Magn Reson Med | 1993 | 8139448 | Yes |
| 606 | 2975 | 2975.0 | 68.81 | 68.8 | Chemokines--chemotactic cytokines that mediate inflammation. | A D Luster | N Engl J Med | 1998 | 9459648 | No |
| 607 | 2975 | 2975.0 | 54.82 | 54.8 | RNA interference. | Gregory J Hannon | Nature | 2002 | 12110901 | No |
| 608 | 2973 | 2973.0 | 52.91 | 52.9 | The gel-filtration behaviour of proteins related to their molecular weights over a wide range. | P Andrews | Biochem J | 1965 | 5862401 | Yes |
| 609 | 5943 | 2971.5 | 124.88 | 62.4 | Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. | D B Smith, K S Johnson | Gene | 1988 | 3047011 | Yes |
| 610 | 8905 | 2968.3 | 289.37 | 96.5 | Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. | R A Deyo, D C Cherkin, M A Ciol | J Clin Epidemiol | 1992 | 1607900 | Yes |
| 611 | 5930 | 2965.0 | 125.23 | 62.6 | Emergence of scaling in random networks. | AL Barabasi, R Albert | Science | 1999 | 10521342 | Yes |
| 612 | 2963 | 2963.0 | 94.22 | 94.2 | An empirical correction for absorption anisotropy. | R H Blessing | Acta Crystallogr A | 1995 | 7702794 | Yes |
| 613 | 2962 | 2962.0 | 69.75 | 69.8 | MapChart: software for the graphical presentation of linkage maps and QTLs. | R E Voorrips | J Hered | 2002 | 12011185 | Yes |
| 614 | 2961 | 2961.0 | 91.35 | 91.3 | Matrix metalloproteinases and their inhibitors in connective tissue remodeling. | J F Woessner | FASEB J | 1991 | 1850705 | No |
| 615 | 2952 | 2952.0 | 66.38 | 66.4 | Autophagy: process and function. | Noboru Mizushima | Genes Dev | 2007 | 18006683 | No |
| 616 | 5904 | 2952.0 | 152.93 | 76.5 | Pattern recognition receptors and inflammation. | Osamu Takeuchi, Shizuo Akira | Cell | 2010 | 20303872 | No |
| 617 | 8845 | 2948.3 | 446.17 | 148.7 | Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. | P J Van Soest, J B Robertson, B A Lewis | J Dairy Sci | 1991 | 1660498 | No |
| 618 | 11778 | 2944.5 | 520.44 | 130.1 | IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. | Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang Minh | Mol Biol Evol | 2015 | 25371430 | Yes |
| 619 | 8828 | 2942.7 | 241.88 | 80.6 | Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. | Y Gavrieli, Y Sherman, S A Ben-Sasson | J Cell Biol | 1992 | 1400587 | Yes |
| 620 | 5878 | 2939.0 | 184.72 | 92.4 | Tissue engineering. | R Langer, J P Vacanti | Science | 1993 | 8493529 | No |
| 621 | 2935 | 2935.0 | 102.62 | 102.6 | Measures of reliability in sports medicine and science. | W G Hopkins | Sports Med | 2000 | 10907753 | Yes |
| 622 | 5862 | 2931.0 | 243.91 | 122.0 | Assessment of outcome after severe brain damage. | B Jennett, M Bond | Lancet | 1975 | 46957 | Yes |
| 623 | 2926 | 2926.0 | 65.87 | 65.9 | Calcium signaling. | David E Clapham | Cell | 2007 | 18083096 | No |
| 624 | 8764 | 2921.3 | 202.33 | 67.4 | The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. | R C Lee, R L Feinbaum, V Ambros | Cell | 1993 | 8252621 | Yes |
| 625 | 5839 | 2919.5 | 122.06 | 61.0 | Inflammation and cancer: back to Virchow? | F Balkwill, A Mantovani | Lancet | 2001 | 11229684 | No |
| 626 | 2917 | 2917.0 | 47.24 | 47.2 | A Rationale And Test For The Number Of Factors In Factor Analysis. | J L Horn | Psychometrika | 1965 | 14306381 | Yes |
| 627 | 11666 | 2916.5 | 342.33 | 85.6 | Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. | Qiong Wang, George M Garrity, James M Tiedje, James R Cole | Appl Environ Microbiol | 2007 | 17586664 | Yes |
| 628 | 2916 | 2916.0 | 43.91 | 43.9 | Towards a network theory of the immune system. | N K Jerne | Ann Immunol (Paris) | 1974 | 4142565 | No |
| 629 | 5816 | 2908.0 | 153.42 | 76.7 | Unified segmentation. | John Ashburner, Karl J Friston | Neuroimage | 2005 | 15955494 | Yes |
| 630 | 2908 | 2908.0 | 0.0 | 0.0 | The genetical structure of populations. | S Wright | Ann Eugen | 1951 | 24540312 | Yes |
| 631 | 2899 | 2899.0 | 68.55 | 68.5 | Structure and function of telomeres. | E H Blackburn | Nature | 1991 | 1708110 | No |
| 632 | 2898 | 2898.0 | 29.26 | 29.3 | Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. | P Mitchell | Nature | 1961 | 13771349 | Yes |
| 633 | 2897 | 2897.0 | 70.54 | 70.5 | Phase separation of integral membrane proteins in Triton X-114 solution. | C Bordier | J Biol Chem | 1981 | 6257680 | Yes |
| 634 | 8690 | 2896.7 | 0.0 | 0.0 | The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. | R J Havel, H A Eder, J H Bragdon | J Clin Invest | 1955 | 13252080 | Yes |
| 635 | 5790 | 2895.0 | 161.92 | 81.0 | Inositol trisphosphate, a novel second messenger in cellular signal transduction. | M J Berridge, R F Irvine | Nature | 1984 | 6095092 | No |
| 636 | 2894 | 2894.0 | 122.3 | 122.3 | Statistics corner: A guide to appropriate use of correlation coefficient in medical research. | M M Mukaka | Malawi Med J | 2012 | 23638278 | Yes |
| 637 | 5779 | 2889.5 | 177.9 | 89.0 | The fluid mosaic model of the structure of cell membranes. | S J Singer, G L Nicolson | Science | 1972 | 4333397 | Yes |
| 638 | 2889 | 2889.0 | 67.33 | 67.3 | Modularity and community structure in networks. | M E J Newman | Proc Natl Acad Sci U S A | 2006 | 16723398 | Yes |
| 639 | 2888 | 2888.0 | 61.87 | 61.9 | Inflammatory bowel disease. | Daniel K Podolsky | N Engl J Med | 2002 | 12167685 | No |
| 640 | 2887 | 2887.0 | 107.1 | 107.1 | Role of nrf2 in oxidative stress and toxicity. | Qiang Ma | Annu Rev Pharmacol Toxicol | 2013 | 23294312 | No |
| 641 | 2883 | 2883.0 | 59.79 | 59.8 | Principles of CDK regulation. | D O Morgan | Nature | 1995 | 7877684 | No |
| 642 | 2880 | 2880.0 | 85.97 | 86.0 | Implications of normal brain development for the pathogenesis of schizophrenia. | D R Weinberger | Arch Gen Psychiatry | 1987 | 3606332 | Yes |
| 643 | 5754 | 2877.0 | 126.61 | 63.3 | Oncomirs - microRNAs with a role in cancer. | Aurora Esquela-Kerscher, Frank J Slack | Nat Rev Cancer | 2006 | 16557279 | No |
| 644 | 2872 | 2872.0 | 50.46 | 50.5 | A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. | E A Gehan | Biometrika | 1965 | 14341275 | Yes |
| 645 | 2866 | 2866.0 | 50.77 | 50.8 | One-step gene disruption in yeast. | R J Rothstein | Methods Enzymol | 1983 | 6310324 | Yes |
| 646 | 2861 | 2861.0 | 95.57 | 95.6 | Role of oxidative stress in development of complications in diabetes. | J W Baynes | Diabetes | 1991 | 2010041 | No |
| 647 | 2861 | 2861.0 | 0.0 | 0.0 | Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. | W C Schneider | J Biol Chem | 1945 | 21005736 | Yes |
| 648 | 2859 | 2859.0 | 56.5 | 56.5 | Papillomaviruses and cancer: from basic studies to clinical application. | Harald zur Hausen | Nat Rev Cancer | 2002 | 12044010 | No |
| 649 | 2858 | 2858.0 | 52.34 | 52.3 | Genome maintenance mechanisms for preventing cancer. | J H Hoeijmakers | Nature | 2001 | 11357144 | No |
| 650 | 2858 | 2858.0 | 55.73 | 55.7 | Interleukin-12 and the regulation of innate resistance and adaptive immunity. | Giorgio Trinchieri | Nat Rev Immunol | 2003 | 12563297 | No |
| 651 | 2856 | 2856.0 | 71.99 | 72.0 | Analysis of gene diversity in subdivided populations. | M Nei | Proc Natl Acad Sci U S A | 1973 | 4519626 | Yes |
| 652 | 2856 | 2856.0 | 0.0 | 0.0 | Notes on sugar determination. | M Smogyi | J Biol Chem | 1952 | 14938350 | Yes |
| 653 | 2854 | 2854.0 | 56.02 | 56.0 | A gene complex controlling segmentation in Drosophila. | E B Lewis | Nature | 1978 | 103000 | Yes |
| 654 | 5702 | 2851.0 | 248.64 | 124.3 | Revised methods for the Salmonella mutagenicity test. | D M Maron, B N Ames | Mutat Res | 1983 | 6341825 | Yes |
| 655 | 2850 | 2850.0 | 61.03 | 61.0 | Nuclear factor-kappaB in cancer development and progression. | Michael Karin | Nature | 2006 | 16724054 | No |
| 656 | 8546 | 2848.7 | 246.9 | 82.3 | Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. | G Fairbanks, T L Steck, D F Wallach | Biochemistry | 1971 | 4326772 | Yes |
| 657 | 2846 | 2846.0 | 63.48 | 63.5 | Salt and drought stress signal transduction in plants. | Jian-Kang Zhu | Annu Rev Plant Biol | 2002 | 12221975 | No |
| 658 | 2836 | 2836.0 | 93.76 | 93.8 | Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. | B E Murphy | J Clin Endocrinol Metab | 1967 | 4291524 | Yes |
| 659 | 11342 | 2835.5 | 1347.98 | 337.0 | Cancer Statistics, 2021. | Rebecca L Siegel, Kimberly D Miller, Hannah E Fuchs, Ahmedin Jemal | CA Cancer J Clin | 2021 | 33433946 | Yes |
| 660 | 2835 | 2835.0 | 0.0 | 0.0 | A study of the adrenotropic receptors. | R P Ahlquist | Am J Physiol | 1948 | 18882199 | Yes |
| 661 | 8487 | 2829.0 | 364.41 | 121.5 | Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. | J L Cox, J M Holden, R Sagovsky | Br J Psychiatry | 1987 | 3651732 | Yes |
| 662 | 5658 | 2829.0 | 268.82 | 134.4 | Stress, social support, and the buffering hypothesis. | S Cohen, T A Wills | Psychol Bull | 1985 | 3901065 | No |
| 663 | 2828 | 2828.0 | 82.21 | 82.2 | Separation of leukocytes from blood and bone marrow. Introduction. | A Böyum | Scand J Clin Lab Invest Suppl | 1968 | 5707208 | Yes |
| 664 | 5644 | 2822.0 | 143.44 | 71.7 | Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. | J Glowinski, L L Iversen | J Neurochem | 1966 | 5950056 | Yes |
| 665 | 8464 | 2821.3 | 207.07 | 69.0 | Canonical sampling through velocity rescaling. | Giovanni Bussi, Davide Donadio, Michele Parrinello | J Chem Phys | 2007 | 17212484 | Yes |
| 666 | 2819 | 2819.0 | 53.7 | 53.7 | Elastic properties of lipid bilayers: theory and possible experiments. | W Helfrich | Z Naturforsch C | 1973 | 4273690 | Yes |
| 667 | 2818 | 2818.0 | 85.28 | 85.3 | Primate models of movement disorders of basal ganglia origin. | M R DeLong | Trends Neurosci | 1990 | 1695404 | No |
| 668 | 5635 | 2817.5 | 173.92 | 87.0 | Computed tomography--an increasing source of radiation exposure. | David J Brenner, Eric J Hall | N Engl J Med | 2007 | 18046031 | No |
| 669 | 2814 | 2814.0 | 121.4 | 121.4 | Colorimetric assay of catalase. | A K Sinha | Anal Biochem | 1972 | 4556490 | Yes |
| 670 | 5621 | 2810.5 | 112.79 | 56.4 | Establishment in culture of pluripotential cells from mouse embryos. | M J Evans, M H Kaufman | Nature | 1981 | 7242681 | Yes |
| 671 | 2805 | 2805.0 | 126.44 | 126.4 | Detecting alcoholism. The CAGE questionnaire. | J A Ewing | JAMA | 1984 | 6471323 | Yes |
| 672 | 2805 | 2805.0 | 47.64 | 47.6 | Mechanisms underlying ubiquitination. | C M Pickart | Annu Rev Biochem | 2001 | 11395416 | No |
| 673 | 2803 | 2803.0 | 90.33 | 90.3 | Stereotaxic mapping of the monoamine pathways in the rat brain. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4109331 | Yes |
| 674 | 2803 | 2803.0 | 66.32 | 66.3 | T cell exhaustion. | E John Wherry | Nat Immunol | 2011 | 21739672 | No |
| 675 | 2803 | 2803.0 | 152.72 | 152.7 | Hepatocellular Carcinoma. | Augusto Villanueva | N Engl J Med | 2019 | 30970190 | No |
| 676 | 5604 | 2802.0 | 192.68 | 96.3 | A method of comparing the areas under receiver operating characteristic curves derived from the same cases. | J A Hanley, B J McNeil | Radiology | 1983 | 6878708 | Yes |
| 677 | 5600 | 2800.0 | 134.69 | 67.3 | Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. | S Marklund, G Marklund | Eur J Biochem | 1974 | 4215654 | Yes |
| 678 | 5600 | 2800.0 | 152.56 | 76.3 | The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. | J Vieira, J Messing | Gene | 1982 | 6295879 | Yes |
| 679 | 8384 | 2794.7 | 245.73 | 81.9 | FastTree 2--approximately maximum-likelihood trees for large alignments. | Morgan N Price, Paramvir S Dehal, Adam P Arkin | PLoS One | 2010 | 20224823 | Yes |
| 680 | 5586 | 2793.0 | 126.6 | 63.3 | Caspases: enemies within. | N A Thornberry, Y Lazebnik | Science | 1998 | 9721091 | No |
| 681 | 8379 | 2793.0 | 190.21 | 63.4 | Pathogen recognition and innate immunity. | Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi | Cell | 2006 | 16497588 | No |
| 682 | 5584 | 2792.0 | 185.45 | 92.7 | Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. | J Sedlak, R H Lindsay | Anal Biochem | 1968 | 4973948 | Yes |
| 683 | 2791 | 2791.0 | 70.02 | 70.0 | Dietary pattern analysis: a new direction in nutritional epidemiology. | Frank B Hu | Curr Opin Lipidol | 2002 | 11790957 | No |
| 684 | 2790 | 2790.0 | 78.28 | 78.3 | Parkinson's disease: clinical features and diagnosis. | J Jankovic | J Neurol Neurosurg Psychiatry | 2008 | 18344392 | No |
| 685 | 5579 | 2789.5 | 77.82 | 38.9 | A method for determining the sedimentation behavior of enzymes: application to protein mixtures. | R G Martin, B N Ames | J Biol Chem | 1961 | 13767412 | Yes |
| 686 | 2789 | 2789.0 | 70.54 | 70.5 | The genetic legacy of the Quaternary ice ages. | G Hewitt | Nature | 2000 | 10879524 | No |
| 687 | 5575 | 2787.5 | 109.97 | 55.0 | Innate immune recognition. | Charles A Janeway, Ruslan Medzhitov | Annu Rev Immunol | 2002 | 11861602 | No |
| 688 | 2784 | 2784.0 | 112.56 | 112.6 | Microplastics in the marine environment. | Anthony L Andrady | Mar Pollut Bull | 2011 | 21742351 | No |
| 689 | 11133 | 2783.2 | 297.54 | 74.4 | Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. | P W Rigby, M Dieckmann, C Rhodes, P Berg | J Mol Biol | 1977 | 881736 | Yes |
| 690 | 2778 | 2778.0 | 69.75 | 69.8 | Models for the specific adhesion of cells to cells. | G I Bell | Science | 1978 | 347575 | No |
| 691 | 2778 | 2778.0 | 109.18 | 109.2 | A simple technique for demonstrating centromeric heterochromatin. | A T Sumner | Exp Cell Res | 1972 | 4117921 | Yes |
| 692 | 2778 | 2778.0 | 65.05 | 65.0 | Molecular chaperones in cellular protein folding. | F U Hartl | Nature | 1996 | 8637592 | No |
| 693 | 2776 | 2776.0 | 80.44 | 80.4 | The unfolded protein response: controlling cell fate decisions under ER stress and beyond. | Claudio Hetz | Nat Rev Mol Cell Biol | 2012 | 22251901 | No |
| 694 | 5545 | 2772.5 | 199.91 | 100.0 | Longitudinal data analysis for discrete and continuous outcomes. | S L Zeger, K Y Liang | Biometrics | 1986 | 3719049 | Yes |
| 695 | 2772 | 2772.0 | 0.0 | 0.0 | Efficient trace-labelling of proteins with iodine. | A S McFARLANE | Nature | 1958 | 13566175 | Yes |
| 696 | 11083 | 2770.8 | 335.79 | 83.9 | Cancer statistics, 2010. | Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth Ward | CA Cancer J Clin | 2010 | 20610543 | Yes |
| 697 | 5529 | 2764.5 | 152.54 | 76.3 | Adherence to medication. | Lars Osterberg, Terrence Blaschke | N Engl J Med | 2005 | 16079372 | No |
| 698 | 5527 | 2763.5 | 130.41 | 65.2 | Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. | F W Studier, B A Moffatt | J Mol Biol | 1986 | 3537305 | Yes |
| 699 | 5516 | 2758.0 | 133.66 | 66.8 | Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. | D Hanahan, J Folkman | Cell | 1996 | 8756718 | No |
| 700 | 2757 | 2757.0 | 82.78 | 82.8 | SF-36 health survey update. | J E Ware | Spine (Phila Pa 1976) | 2000 | 11124729 | No |
| 701 | 5509 | 2754.5 | 127.79 | 63.9 | Autophagy in the pathogenesis of disease. | Beth Levine, Guido Kroemer | Cell | 2008 | 18191218 | No |
| 702 | 5499 | 2749.5 | 91.18 | 45.6 | A modified uronic acid carbazole reaction. | T Bitter, H M Muir | Anal Biochem | 1962 | 13971270 | Yes |
| 703 | 5496 | 2748.0 | 185.96 | 93.0 | Extracellular vesicles: exosomes, microvesicles, and friends. | Graça Raposo, Willem Stoorvogel | J Cell Biol | 2013 | 23420871 | No |
| 704 | 2745 | 2745.0 | 0.0 | 0.0 | Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. | L Svennerholm | Biochim Biophys Acta | 1957 | 13436486 | Yes |
| 705 | 2744 | 2744.0 | 66.05 | 66.0 | Cell death during development of the nervous system. | R W Oppenheim | Annu Rev Neurosci | 1991 | 2031577 | No |
| 706 | 8231 | 2743.7 | 277.43 | 92.5 | Effect of the damping function in dispersion corrected density functional theory. | Stefan Grimme, Stephan Ehrlich, Lars Goerigk | J Comput Chem | 2011 | 21370243 | Yes |
| 707 | 2742 | 2742.0 | 72.57 | 72.6 | The magical number 4 in short-term memory: a reconsideration of mental storage capacity. | N Cowan | Behav Brain Sci | 2001 | 11515286 | Yes |
| 708 | 5479 | 2739.5 | 160.24 | 80.1 | Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. | Jeng-Da Chai, Martin Head-Gordon | Phys Chem Chem Phys | 2008 | 18989472 | Yes |
| 709 | 2738 | 2738.0 | 70.51 | 70.5 | Predictive reward signal of dopamine neurons. | W Schultz | J Neurophysiol | 1998 | 9658025 | No |
| 710 | 2738 | 2738.0 | 58.94 | 58.9 | Bone resorption by osteoclasts. | S L Teitelbaum | Science | 2000 | 10968780 | No |
| 711 | 2736 | 2736.0 | 61.67 | 61.7 | Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. | S A Bustin | J Mol Endocrinol | 2000 | 11013345 | No |
| 712 | 5468 | 2734.0 | 166.79 | 83.4 | Glutathione. | A Meister, M E Anderson | Annu Rev Biochem | 1983 | 6137189 | No |
| 713 | 2733 | 2733.0 | 53.01 | 53.0 | The danger model: a renewed sense of self. | Polly Matzinger | Science | 2002 | 11951032 | Yes |
| 714 | 5444 | 2722.0 | 107.52 | 53.8 | High-efficiency transformation of mammalian cells by plasmid DNA. | C Chen, H Okayama | Mol Cell Biol | 1987 | 3670292 | Yes |
| 715 | 8142 | 2714.0 | 175.39 | 58.5 | Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. | C M Gorman, L F Moffat, B H Howard | Mol Cell Biol | 1982 | 6960240 | Yes |
| 716 | 2707 | 2707.0 | 85.22 | 85.2 | Social cognitive theory: an agentic perspective. | A Bandura | Annu Rev Psychol | 2001 | 11148297 | Yes |
| 717 | 2704 | 2704.0 | 62.56 | 62.6 | Memory--a century of consolidation. | J L McGaugh | Science | 2000 | 10634773 | No |
| 718 | 2701 | 2701.0 | 60.85 | 60.9 | Cell adhesion: the molecular basis of tissue architecture and morphogenesis. | B M Gumbiner | Cell | 1996 | 8608588 | No |
| 719 | 5402 | 2701.0 | 185.12 | 92.6 | The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. | S H Downs, N Black | J Epidemiol Community Health | 1998 | 9764259 | Yes |
| 720 | 5400 | 2700.0 | 153.76 | 76.9 | The Social Readjustment Rating Scale. | T H Holmes, R H Rahe | J Psychosom Res | 1967 | 6059863 | Yes |
| 721 | 10778 | 2694.5 | 316.97 | 79.2 | Establishing a standard definition for child overweight and obesity worldwide: international survey. | T J Cole, M C Bellizzi, K M Flegal, W H Dietz | BMJ | 2000 | 10797032 | Yes |
| 722 | 16142 | 2690.3 | 360.07 | 60.0 | Phaser crystallographic software. | Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J Read | J Appl Crystallogr | 2007 | 19461840 | Yes |
| 723 | 2686 | 2686.0 | 64.89 | 64.9 | Molecular basis of bacterial outer membrane permeability revisited. | Hiroshi Nikaido | Microbiol Mol Biol Rev | 2003 | 14665678 | No |
| 724 | 8056 | 2685.3 | 199.27 | 66.4 | MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. | Sudhir Kumar, Koichiro Tamura, Masatoshi Nei | Brief Bioinform | 2004 | 15260895 | Yes |
| 725 | 2685 | 2685.0 | 58.93 | 58.9 | On the number of segregating sites in genetical models without recombination. | G A Watterson | Theor Popul Biol | 1975 | 1145509 | Yes |
| 726 | 10734 | 2683.5 | 227.44 | 56.9 | Cluster analysis and display of genome-wide expression patterns. | M B Eisen, P T Spellman, P O Brown, D Botstein | Proc Natl Acad Sci U S A | 1998 | 9843981 | Yes |
| 727 | 2682 | 2682.0 | 60.23 | 60.2 | Prostaglandins and leukotrienes: advances in eicosanoid biology. | C D Funk | Science | 2001 | 11729303 | No |
| 728 | 2677 | 2677.0 | 23.42 | 23.4 | Satellite cell of skeletal muscle fibers. | A Mauro | J Biophys Biochem Cytol | 1961 | 13768451 | Yes |
| 729 | 2675 | 2675.0 | 51.48 | 51.5 | Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. | Shimon Sakaguchi | Annu Rev Immunol | 2004 | 15032588 | No |
| 730 | 2674 | 2674.0 | 104.29 | 104.3 | Central sensitization: implications for the diagnosis and treatment of pain. | Clifford J Woolf | Pain | 2011 | 20961685 | No |
| 731 | 5338 | 2669.0 | 163.98 | 82.0 | Rapid isolation of high molecular weight plant DNA. | M G Murray, W F Thompson | Nucleic Acids Res | 1980 | 7433111 | Yes |
| 732 | 2663 | 2663.0 | 60.82 | 60.8 | Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. | G P Smith | Science | 1985 | 4001944 | Yes |
| 733 | 2660 | 2660.0 | 62.1 | 62.1 | Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. | P Cuatrecasas | J Biol Chem | 1970 | 5432796 | Yes |
| 734 | 5319 | 2659.5 | 165.13 | 82.6 | Accurate and simple analytic representation of the electron-gas correlation energy. | J P Perdew, Y Wang | Phys Rev B Condens Matter | 1992 | 10001404 | Yes |
| 735 | 2659 | 2659.0 | 82.14 | 82.1 | The free-energy principle: a unified brain theory? | Karl Friston | Nat Rev Neurosci | 2010 | 20068583 | No |
| 736 | 2658 | 2658.0 | 83.31 | 83.3 | A rating instrument for anxiety disorders. | W W Zung | Psychosomatics | 1971 | 5172928 | Yes |
| 737 | 5312 | 2656.0 | 0.0 | 0.0 | Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. | J D Watson, F H Crick | Nature | 1953 | 13054692 | Yes |
| 738 | 2646 | 2646.0 | 59.5 | 59.5 | Vascular endothelial growth factor: basic science and clinical progress. | Napoleone Ferrara | Endocr Rev | 2004 | 15294883 | No |
| 739 | 5288 | 2644.0 | 210.49 | 105.2 | A feature-integration theory of attention. | A M Treisman, G Gelade | Cogn Psychol | 1980 | 7351125 | Yes |
| 740 | 2641 | 2641.0 | 82.0 | 82.0 | What are the functional consequences of neurocognitive deficits in schizophrenia? | M F Green | Am J Psychiatry | 1996 | 8610818 | No |
| 741 | 2640 | 2640.0 | 107.08 | 107.1 | Qualitative research. Introducing focus groups. | J Kitzinger | BMJ | 1995 | 7633241 | Yes |
| 742 | 2636 | 2636.0 | 75.45 | 75.5 | Stress, adaptation, and disease. Allostasis and allostatic load. | B S McEwen | Ann N Y Acad Sci | 1998 | 9629234 | No |
| 743 | 2632 | 2632.0 | 90.38 | 90.4 | A computational approach to edge detection. | J Canny | IEEE Trans Pattern Anal Mach Intell | 1986 | 21869365 | Yes |
| 744 | 5251 | 2625.5 | 107.81 | 53.9 | MicroRNAs: small RNAs with a big role in gene regulation. | Lin He, Gregory J Hannon | Nat Rev Genet | 2004 | 15211354 | No |
| 745 | 2623 | 2623.0 | 65.26 | 65.3 | The nerve growth factor 35 years later. | R Levi-Montalcini | Science | 1987 | 3306916 | No |
| 746 | 2621 | 2621.0 | 106.08 | 106.1 | The biology of oxygen radicals. | I Fridovich | Science | 1978 | 210504 | Yes |
| 747 | 5236 | 2618.0 | 140.16 | 70.1 | Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. | L A Greene, A S Tischler | Proc Natl Acad Sci U S A | 1976 | 1065897 | Yes |
| 748 | 5236 | 2618.0 | 101.8 | 50.9 | Untangling the ErbB signalling network. | Y Yarden, M X Sliwkowski | Nat Rev Mol Cell Biol | 2001 | 11252954 | No |
| 749 | 2617 | 2617.0 | 132.27 | 132.3 | Conservation of resources. A new attempt at conceptualizing stress. | S E Hobfoll | Am Psychol | 1989 | 2648906 | No |
| 750 | 2612 | 2612.0 | 122.43 | 122.4 | The membrane actions of anesthetics and tranquilizers. | P Seeman | Pharmacol Rev | 1972 | 4565956 | No |
| 751 | 5223 | 2611.5 | 117.26 | 58.6 | Signal transduction by receptors with tyrosine kinase activity. | A Ullrich, J Schlessinger | Cell | 1990 | 2158859 | No |
| 752 | 5222 | 2611.0 | 0.0 | 0.0 | Some quantitative uses of drug antagonists. | O Arunlakshana, H O Schild | Br J Pharmacol Chemother | 1959 | 13651579 | Yes |
| 753 | 2609 | 2609.0 | 98.23 | 98.2 | The biology and function of fibroblasts in cancer. | Raghu Kalluri | Nat Rev Cancer | 2016 | 27550820 | No |
| 754 | 5213 | 2606.5 | 180.62 | 90.3 | A simple, rapid, and sensitive DNA assay procedure. | C Labarca, K Paigen | Anal Biochem | 1980 | 6158890 | Yes |
| 755 | 2606 | 2606.0 | 72.76 | 72.8 | Two-sided confidence intervals for the single proportion: comparison of seven methods. | R G Newcombe | Stat Med | 1998 | 9595616 | Yes |
| 756 | 5199 | 2599.5 | 246.3 | 123.2 | Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. | J Silness, H Loe | Acta Odontol Scand | 1964 | 14158464 | Yes |
| 757 | 2596 | 2596.0 | 50.69 | 50.7 | Tumour-educated macrophages promote tumour progression and metastasis. | Jeffrey W Pollard | Nat Rev Cancer | 2004 | 14708027 | No |
| 758 | 2595 | 2595.0 | 72.25 | 72.2 | Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. | P Correa | Cancer Res | 1992 | 1458460 | No |
| 759 | 2595 | 2595.0 | 56.57 | 56.6 | Epigenetics in cancer. | Manel Esteller | N Engl J Med | 2008 | 18337604 | No |
| 760 | 2592 | 2592.0 | 73.32 | 73.3 | Formation and Structure of Self-Assembled Monolayers. | Abraham Ulman | Chem Rev | 1996 | 11848802 | Yes |
| 761 | 7774 | 2591.3 | 202.96 | 67.7 | Regularization Paths for Generalized Linear Models via Coordinate Descent. | Jerome Friedman, Trevor Hastie, Rob Tibshirani | J Stat Softw | 2010 | 20808728 | Yes |
| 762 | 5179 | 2589.5 | 73.53 | 36.8 | A general method applicable to the search for similarities in the amino acid sequence of two proteins. | S B Needleman, C D Wunsch | J Mol Biol | 1970 | 5420325 | Yes |
| 763 | 2588 | 2588.0 | 55.33 | 55.3 | G1 phase progression: cycling on cue. | C J Sherr | Cell | 1994 | 7954821 | No |
| 764 | 5167 | 2583.5 | 127.31 | 63.7 | Reactive oxygen species: metabolism, oxidative stress, and signal transduction. | Klaus Apel, Heribert Hirt | Annu Rev Plant Biol | 2004 | 15377225 | No |
| 765 | 2582 | 2582.0 | 53.67 | 53.7 | Evolving concepts of rheumatoid arthritis. | Gary S Firestein | Nature | 2003 | 12748655 | No |
| 766 | 2582 | 2582.0 | 61.62 | 61.6 | Cancer nanotechnology: opportunities and challenges. | Mauro Ferrari | Nat Rev Cancer | 2005 | 15738981 | No |
| 767 | 2579 | 2579.0 | 80.64 | 80.6 | Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. | B Samuelsson | Science | 1983 | 6301011 | Yes |
| 768 | 5155 | 2577.5 | 167.48 | 83.7 | The neural basis of drug craving: an incentive-sensitization theory of addiction. | T E Robinson, K C Berridge | Brain Res Brain Res Rev | 1993 | 8401595 | No |
| 769 | 2577 | 2577.0 | 52.48 | 52.5 | Telomere measurement by quantitative PCR. | Richard M Cawthon | Nucleic Acids Res | 2002 | 12000852 | Yes |
| 770 | 5150 | 2575.0 | 160.3 | 80.2 | The L-arginine-nitric oxide pathway. | S Moncada, A Higgs | N Engl J Med | 1993 | 7504210 | No |
| 771 | 2575 | 2575.0 | 71.18 | 71.2 | Physiology and neurobiology of stress and adaptation: central role of the brain. | Bruce S McEwen | Physiol Rev | 2007 | 17615391 | No |
| 772 | 2574 | 2574.0 | 0.0 | 0.0 | The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. | M L Anson | J Gen Physiol | 1938 | 19873094 | Yes |
| 773 | 2571 | 2571.0 | 73.33 | 73.3 | Delayed neuronal death in the gerbil hippocampus following ischemia. | T Kirino | Brain Res | 1982 | 7093691 | Yes |
| 774 | 2570 | 2570.0 | 68.73 | 68.7 | Dominant forces in protein folding. | K A Dill | Biochemistry | 1990 | 2207096 | No |
| 775 | 2567 | 2567.0 | 61.86 | 61.9 | Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. | E C Butcher | Cell | 1991 | 1760836 | No |
| 776 | 2561 | 2561.0 | 79.26 | 79.3 | The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. | B L Fredrickson | Am Psychol | 2001 | 11315248 | Yes |
| 777 | 2560 | 2560.0 | 36.04 | 36.0 | The catecholamine hypothesis of affective disorders: a review of supporting evidence. | J J Schildkraut | Am J Psychiatry | 1965 | 5319766 | No |
| 778 | 2555 | 2555.0 | 0.0 | 0.0 | The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. | R R Porter | Biochem J | 1959 | 14434282 | Yes |
| 779 | 2554 | 2554.0 | 125.73 | 125.7 | The antibiotic resistance crisis: part 1: causes and threats. | C Lee Ventola | P T | 2015 | 25859123 | Yes |
| 780 | 2545 | 2545.0 | 67.13 | 67.1 | Evaluating the quality of medical care. | A Donabedian | Milbank Mem Fund Q | 1966 | 5338568 | No |
| 781 | 2545 | 2545.0 | 0.0 | 0.0 | Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. | O Smithies | Biochem J | 1955 | 13276348 | Yes |
| 782 | 2543 | 2543.0 | 54.92 | 54.9 | Angiogenesis in life, disease and medicine. | Peter Carmeliet | Nature | 2005 | 16355210 | No |
| 783 | 5082 | 2541.0 | 158.41 | 79.2 | Microenvironmental regulation of tumor progression and metastasis. | Daniela F Quail, Johanna A Joyce | Nat Med | 2013 | 24202395 | No |
| 784 | 5069 | 2534.5 | 276.59 | 138.3 | A diagnostic interview: the schedule for affective disorders and schizophrenia. | J Endicott, R L Spitzer | Arch Gen Psychiatry | 1978 | 678037 | Yes |
| 785 | 2533 | 2533.0 | 51.04 | 51.0 | Universal control mechanism regulating onset of M-phase. | P Nurse | Nature | 1990 | 2138713 | No |
| 786 | 2533 | 2533.0 | 61.85 | 61.9 | A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. | Pascal Fries | Trends Cogn Sci | 2005 | 16150631 | No |
| 787 | 5065 | 2532.5 | 222.72 | 111.4 | Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. | N S Jacobson, P Truax | J Consult Clin Psychol | 1991 | 2002127 | Yes |
| 788 | 2529 | 2529.0 | 28.16 | 28.2 | The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. | S Boyden | J Exp Med | 1962 | 13872176 | Yes |
| 789 | 2529 | 2529.0 | 82.93 | 82.9 | Gctf: Real-time CTF determination and correction. | Kai Zhang | J Struct Biol | 2016 | 26592709 | Yes |
| 790 | 7573 | 2524.3 | 198.93 | 66.3 | Immunity, inflammation, and cancer. | Sergei I Grivennikov, Florian R Greten, Michael Karin | Cell | 2010 | 20303878 | No |
| 791 | 2523 | 2523.0 | 74.1 | 74.1 | Perceived exertion as an indicator of somatic stress. | G Borg | Scand J Rehabil Med | 1970 | 5523831 | Yes |
| 792 | 5041 | 2520.5 | 116.09 | 58.0 | Myeloid-derived suppressor cells as regulators of the immune system. | Dmitry I Gabrilovich, Srinivas Nagaraj | Nat Rev Immunol | 2009 | 19197294 | No |
| 793 | 2513 | 2513.0 | 77.17 | 77.2 | Secretory products of macrophages. | C F Nathan | J Clin Invest | 1987 | 3543052 | No |
| 794 | 7535 | 2511.7 | 204.34 | 68.1 | Quantum mechanical continuum solvation models. | Jacopo Tomasi, Benedetta Mennucci, Roberto Cammi | Chem Rev | 2005 | 16092826 | Yes |
| 795 | 2509 | 2509.0 | 54.97 | 55.0 | The distribution of secondary growths in cancer of the breast. 1889. | S Paget | Cancer Metastasis Rev | 1989 | 2673568 | No |
| 796 | 5012 | 2506.0 | 129.56 | 64.8 | UniFrac: a new phylogenetic method for comparing microbial communities. | Catherine Lozupone, Rob Knight | Appl Environ Microbiol | 2005 | 16332807 | Yes |
| 797 | 7516 | 2505.3 | 187.22 | 62.4 | RNA-Seq: a revolutionary tool for transcriptomics. | Zhong Wang, Mark Gerstein, Michael Snyder | Nat Rev Genet | 2009 | 19015660 | No |
| 798 | 5010 | 2505.0 | 100.25 | 50.1 | Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. | D Bonnet, J E Dick | Nat Med | 1997 | 9212098 | Yes |
| 799 | 10014 | 2503.5 | 401.67 | 100.4 | Cancer statistics, 2014. | Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin Jemal | CA Cancer J Clin | 2014 | 24399786 | Yes |
| 800 | 2503 | 2503.0 | 44.91 | 44.9 | Wnt signaling and cancer. | P Polakis | Genes Dev | 2000 | 10921899 | No |
| 801 | 7498 | 2499.3 | 215.44 | 71.8 | GSVA: gene set variation analysis for microarray and RNA-seq data. | Sonja Hänzelmann, Robert Castelo, Justin Guinney | BMC Bioinformatics | 2013 | 23323831 | Yes |
| 802 | 7487 | 2495.7 | 193.65 | 64.5 | Cortical surface-based analysis. I. Segmentation and surface reconstruction. | A M Dale, B Fischl, M I Sereno | Neuroimage | 1999 | 9931268 | Yes |
| 803 | 2495 | 2495.0 | 61.98 | 62.0 | Immunological and inflammatory functions of the interleukin-1 family. | Charles A Dinarello | Annu Rev Immunol | 2009 | 19302047 | No |
| 804 | 4983 | 2491.5 | 181.6 | 90.8 | Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. | P J Fraker, J C Speck | Biochem Biophys Res Commun | 1978 | 637870 | Yes |
| 805 | 4982 | 2491.0 | 147.89 | 73.9 | SPSS and SAS procedures for estimating indirect effects in simple mediation models. | Kristopher J Preacher, Andrew F Hayes | Behav Res Methods Instrum Comput | 2004 | 15641418 | Yes |
| 806 | 4979 | 2489.5 | 141.46 | 70.7 | Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. | J V Durnin, J Womersley | Br J Nutr | 1974 | 4843734 | Yes |
| 807 | 4974 | 2487.0 | 123.38 | 61.7 | A global optimisation method for robust affine registration of brain images. | M Jenkinson, S Smith | Med Image Anal | 2001 | 11516708 | Yes |
| 808 | 9942 | 2485.5 | 1962.88 | 490.7 | Cancer statistics, 2022. | Rebecca L Siegel, Kimberly D Miller, Hannah E Fuchs, Ahmedin Jemal | CA Cancer J Clin | 2022 | 35020204 | Yes |
| 809 | 4966 | 2483.0 | 119.73 | 59.9 | Calculation of protein extinction coefficients from amino acid sequence data. | S C Gill, P H von Hippel | Anal Biochem | 1989 | 2610349 | Yes |
| 810 | 4956 | 2478.0 | 96.24 | 48.1 | CDK inhibitors: positive and negative regulators of G1-phase progression. | C J Sherr, J M Roberts | Genes Dev | 1999 | 10385618 | No |
| 811 | 2472 | 2472.0 | 112.15 | 112.2 | Oxygen-dependent microbial killing by phagocytes (first of two parts). | B M Babior | N Engl J Med | 1978 | 24176 | Yes |
| 812 | 2472 | 2472.0 | 92.42 | 92.4 | Missing data analysis: making it work in the real world. | John W Graham | Annu Rev Psychol | 2009 | 18652544 | No |
| 813 | 2470 | 2470.0 | 46.96 | 47.0 | Mechanisms of type-I- and type-II-interferon-mediated signalling. | Leonidas C Platanias | Nat Rev Immunol | 2005 | 15864272 | No |
| 814 | 2466 | 2466.0 | 61.91 | 61.9 | Inferring the historical patterns of biological evolution. | M Pagel | Nature | 1999 | 10553904 | Yes |
| 815 | 2459 | 2459.0 | 0.0 | 0.0 | Transduction of linked genetic characters of the host by bacteriophage P1. | E S Lennox | Virology | 1955 | 13267987 | Yes |
| 816 | 4915 | 2457.5 | 142.01 | 71.0 | Nonparametric statistical testing of EEG- and MEG-data. | Eric Maris, Robert Oostenveld | J Neurosci Methods | 2007 | 17517438 | Yes |
| 817 | 7348 | 2449.3 | 209.14 | 69.7 | Bacterial biofilms: a common cause of persistent infections. | J W Costerton, P S Stewart, E P Greenberg | Science | 1999 | 10334980 | No |
| 818 | 2446 | 2446.0 | 53.42 | 53.4 | Rab GTPases as coordinators of vesicle traffic. | Harald Stenmark | Nat Rev Mol Cell Biol | 2009 | 19603039 | No |
| 819 | 4891 | 2445.5 | 130.07 | 65.0 | Alzheimer's disease: the amyloid cascade hypothesis. | J A Hardy, G A Higgins | Science | 1992 | 1566067 | No |
| 820 | 4890 | 2445.0 | 103.7 | 51.9 | Judgment under Uncertainty: Heuristics and Biases. | A Tversky, D Kahneman | Science | 1974 | 17835457 | Yes |
| 821 | 4887 | 2443.5 | 108.42 | 54.2 | Signal integration in the endoplasmic reticulum unfolded protein response. | David Ron, Peter Walter | Nat Rev Mol Cell Biol | 2007 | 17565364 | No |
| 822 | 2441 | 2441.0 | 78.25 | 78.2 | Plant products as antimicrobial agents. | M M Cowan | Clin Microbiol Rev | 1999 | 10515903 | No |
| 823 | 2441 | 2441.0 | 0.0 | 0.0 | The information capacity of the human motor system in controlling the amplitude of movement. | P M Fitts | J Exp Psychol | 1954 | 13174710 | Yes |
| 824 | 2440 | 2440.0 | 65.55 | 65.5 | Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. | H G Gratzner | Science | 1982 | 7123245 | Yes |
| 825 | 2440 | 2440.0 | 110.57 | 110.6 | Structural Model Evaluation and Modification: An Interval Estimation Approach. | J H Steiger | Multivariate Behav Res | 1990 | 26794479 | Yes |
| 826 | 2439 | 2439.0 | 47.26 | 47.3 | Getting started with yeast. | F Sherman | Methods Enzymol | 1991 | 2005794 | Yes |
| 827 | 2438 | 2438.0 | 58.52 | 58.5 | An index to quantify an individual's scientific research output. | J E Hirsch | Proc Natl Acad Sci U S A | 2005 | 16275915 | Yes |
| 828 | 2438 | 2438.0 | 57.92 | 57.9 | Causes and consequences of microRNA dysregulation in cancer. | Carlo M Croce | Nat Rev Genet | 2009 | 19763153 | No |
| 829 | 2437 | 2437.0 | 54.07 | 54.1 | Social controls on cell survival and cell death. | M C Raff | Nature | 1992 | 1557121 | No |
| 830 | 2434 | 2434.0 | 82.31 | 82.3 | Doxil®--the first FDA-approved nano-drug: lessons learned. | Yechezkel Barenholz | J Control Release | 2012 | 22484195 | No |
| 831 | 9729 | 2432.2 | 253.4 | 63.4 | GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. | Berk Hess, Carsten Kutzner, David van der Spoel, Erik Lindahl | J Chem Theory Comput | 2008 | 26620784 | Yes |
| 832 | 2431 | 2431.0 | 130.74 | 130.7 | Determination and quantification of content validity. | M R Lynn | Nurs Res | 1986 | 3640358 | Yes |
| 833 | 4859 | 2429.5 | 120.91 | 60.5 | The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. | Karen Bedard, Karl-Heinz Krause | Physiol Rev | 2007 | 17237347 | No |
| 834 | 9709 | 2427.2 | 231.95 | 58.0 | Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. | C A Lipinski, F Lombardo, B W Dominy, P J Feeney | Adv Drug Deliv Rev | 2001 | 11259830 | No |
| 835 | 2421 | 2421.0 | 61.21 | 61.2 | Network pharmacology: the next paradigm in drug discovery. | Andrew L Hopkins | Nat Chem Biol | 2008 | 18936753 | No |
| 836 | 4840 | 2420.0 | 68.6 | 34.3 | Periodontal Disease In Pregnancy. I. Prevalence And Severity. | H Loe, J Silness | Acta Odontol Scand | 1963 | 14121956 | Yes |
| 837 | 2418 | 2418.0 | 80.28 | 80.3 | Working memory. | A Baddeley | Science | 1992 | 1736359 | No |
| 838 | 4826 | 2413.0 | 157.15 | 78.6 | Random-effects models for longitudinal data. | N M Laird, J H Ware | Biometrics | 1982 | 7168798 | Yes |
| 839 | 2413 | 2413.0 | 53.78 | 53.8 | The inflammatory reflex. | Kevin J Tracey | Nature | 2002 | 12490958 | No |
| 840 | 2413 | 2413.0 | 50.5 | 50.5 | Cisplatin: mode of cytotoxic action and molecular basis of resistance. | Zahid H Siddik | Oncogene | 2003 | 14576837 | No |
| 841 | 2411 | 2411.0 | 52.64 | 52.6 | Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. | T Hunter | Cell | 1995 | 7834742 | No |
| 842 | 4819 | 2409.5 | 142.14 | 71.1 | Missing data: our view of the state of the art. | Joseph L Schafer, John W Graham | Psychol Methods | 2002 | 12090408 | Yes |
| 843 | 9631 | 2407.8 | 498.03 | 124.5 | fastp: an ultra-fast all-in-one FASTQ preprocessor. | Shifu Chen, Yanqing Zhou, Yaru Chen, Jia Gu | Bioinformatics | 2018 | 30423086 | Yes |
| 844 | 4814 | 2407.0 | 92.73 | 46.4 | The phosphatidylinositol 3-Kinase AKT pathway in human cancer. | Igor Vivanco, Charles L Sawyers | Nat Rev Cancer | 2002 | 12094235 | No |
| 845 | 2406 | 2406.0 | 75.67 | 75.7 | Epidemiology of viral hepatitis and hepatocellular carcinoma. | Hashem B El-Serag | Gastroenterology | 2012 | 22537432 | No |
| 846 | 2404 | 2404.0 | 43.77 | 43.8 | Java Treeview--extensible visualization of microarray data. | Alok J Saldanha | Bioinformatics | 2004 | 15180930 | Yes |
| 847 | 4801 | 2400.5 | 114.75 | 57.4 | A scaling normalization method for differential expression analysis of RNA-seq data. | Mark D Robinson, Alicia Oshlack | Genome Biol | 2010 | 20196867 | Yes |
| 848 | 2399 | 2399.0 | 0.0 | 0.0 | Isolation by Distance. | S Wright | Genetics | 1943 | 17247074 | Yes |
| 849 | 4796 | 2398.0 | 142.93 | 71.5 | Neural mechanisms of selective visual attention. | R Desimone, J Duncan | Annu Rev Neurosci | 1995 | 7605061 | No |
| 850 | 4796 | 2398.0 | 93.97 | 47.0 | Lipid rafts and signal transduction. | K Simons, D Toomre | Nat Rev Mol Cell Biol | 2000 | 11413487 | No |
| 851 | 4778 | 2389.0 | 162.73 | 81.4 | The biofilm matrix. | Hans-Curt Flemming, Jost Wingender | Nat Rev Microbiol | 2010 | 20676145 | No |
| 852 | 4777 | 2388.5 | 128.72 | 64.4 | Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. | G Kresse, J Hafner | Phys Rev B Condens Matter | 1994 | 10010505 | Yes |
| 853 | 4772 | 2386.0 | 133.98 | 67.0 | The number of people with glaucoma worldwide in 2010 and 2020. | H A Quigley, A T Broman | Br J Ophthalmol | 2006 | 16488940 | Yes |
| 854 | 2385 | 2385.0 | 54.51 | 54.5 | A decade of molecular biology of retinoic acid receptors. | P Chambon | FASEB J | 1996 | 8801176 | No |
| 855 | 2385 | 2385.0 | 43.33 | 43.3 | Targeting RAS signalling pathways in cancer therapy. | Julian Downward | Nat Rev Cancer | 2003 | 12509763 | No |
| 856 | 4770 | 2385.0 | 120.29 | 60.1 | Management of hepatocellular carcinoma. | Jordi Bruix, Morris Sherman | Hepatology | 2005 | 16250051 | No |
| 857 | 2382 | 2382.0 | 97.97 | 98.0 | The validity and practicality of sun-reactive skin types I through VI. | T B Fitzpatrick | Arch Dermatol | 1988 | 3377516 | Yes |
| 858 | 4764 | 2382.0 | 207.0 | 103.5 | The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. | H P Misra, I Fridovich | J Biol Chem | 1972 | 4623845 | Yes |
| 859 | 2381 | 2381.0 | 92.91 | 92.9 | Effective physician-patient communication and health outcomes: a review. | M A Stewart | CMAJ | 1995 | 7728691 | Yes |
| 860 | 2378 | 2378.0 | 72.16 | 72.2 | A two process model of sleep regulation. | A A Borbély | Hum Neurobiol | 1982 | 7185792 | Yes |
| 861 | 2377 | 2377.0 | 0.0 | 0.0 | Muscle structure and theories of contraction. | A F Huxley | Prog Biophys Biophys Chem | 1957 | 13485191 | Yes |
| 862 | 2375 | 2375.0 | 63.52 | 63.5 | Intestinal mucosal barrier function in health and disease. | Jerrold R Turner | Nat Rev Immunol | 2009 | 19855405 | No |
| 863 | 2374 | 2374.0 | 49.34 | 49.3 | Molecular physiology of P2X receptors. | R Alan North | Physiol Rev | 2002 | 12270951 | No |
| 864 | 2373 | 2373.0 | 51.47 | 51.5 | A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. | Douglas C Wallace | Annu Rev Genet | 2005 | 16285865 | No |
| 865 | 2366 | 2366.0 | 62.25 | 62.2 | A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. | P Chomczynski | Biotechniques | 1993 | 7692896 | Yes |
| 866 | 7097 | 2365.7 | 154.13 | 51.4 | The biology of VEGF and its receptors. | Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter | Nat Med | 2003 | 12778165 | No |
| 867 | 2364 | 2364.0 | 80.61 | 80.6 | A rapid radiochemical method for the determination of choline acetyltransferase. | F Fonnum | J Neurochem | 1975 | 1113118 | Yes |
| 868 | 2362 | 2362.0 | 97.79 | 97.8 | The Michigan alcoholism screening test: the quest for a new diagnostic instrument. | M L Selzer | Am J Psychiatry | 1971 | 5565851 | Yes |
| 869 | 2356 | 2356.0 | 51.61 | 51.6 | Mitochondrial diseases in man and mouse. | D C Wallace | Science | 1999 | 10066162 | No |
| 870 | 4711 | 2355.5 | 97.44 | 48.7 | New functions for the matrix metalloproteinases in cancer progression. | Mikala Egeblad, Zena Werb | Nat Rev Cancer | 2002 | 11990853 | No |
| 871 | 4703 | 2351.5 | 103.17 | 51.6 | Death receptors: signaling and modulation. | A Ashkenazi, V M Dixit | Science | 1998 | 9721089 | No |
| 872 | 7047 | 2349.0 | 69.95 | 23.3 | On The Nature Of Allosteric Transitions: A Plausible Model. | J Monod, J Wyman, J P Changeux | J Mol Biol | 1965 | 14343300 | Yes |
| 873 | 2348 | 2348.0 | 66.64 | 66.6 | Scaffolds in tissue engineering bone and cartilage. | D W Hutmacher | Biomaterials | 2000 | 11071603 | Yes |
| 874 | 4695 | 2347.5 | 127.56 | 63.8 | Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. | Michael D Fox, Marcus E Raichle | Nat Rev Neurosci | 2007 | 17704812 | No |
| 875 | 2347 | 2347.0 | 60.38 | 60.4 | MYC on the path to cancer. | Chi V Dang | Cell | 2012 | 22464321 | No |
| 876 | 4691 | 2345.5 | 117.74 | 58.9 | Acute-phase proteins and other systemic responses to inflammation. | C Gabay, I Kushner | N Engl J Med | 1999 | 9971870 | No |
| 877 | 4691 | 2345.5 | 118.74 | 59.4 | Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. | Marie-Christine Daniel, Didier Astruc | Chem Rev | 2004 | 14719978 | No |
| 878 | 4681 | 2340.5 | 103.18 | 51.6 | AKT/PKB signaling: navigating downstream. | Brendan D Manning, Lewis C Cantley | Cell | 2007 | 17604717 | No |
| 879 | 2338 | 2338.0 | 59.07 | 59.1 | A theory of cortical responses. | Karl Friston | Philos Trans R Soc Lond B Biol Sci | 2005 | 15937014 | No |
| 880 | 4672 | 2336.0 | 103.67 | 51.8 | Screening lambdagt recombinant clones by hybridization to single plaques in situ. | W D Benton, R W Davis | Science | 1977 | 322279 | Yes |
| 881 | 2336 | 2336.0 | 103.42 | 103.4 | Deep learning in neural networks: an overview. | Jürgen Schmidhuber | Neural Netw | 2015 | 25462637 | No |
| 882 | 2335 | 2335.0 | 51.97 | 52.0 | The structure and regulation of protein phosphatases. | P Cohen | Annu Rev Biochem | 1989 | 2549856 | No |
| 883 | 4666 | 2333.0 | 170.98 | 85.5 | Self-rated health and mortality: a review of twenty-seven community studies. | E L Idler, Y Benyamini | J Health Soc Behav | 1997 | 9097506 | No |
| 884 | 2331 | 2331.0 | 55.8 | 55.8 | Lead- and drug-like compounds: the rule-of-five revolution. | Christopher A Lipinski | Drug Discov Today Technol | 2004 | 24981612 | Yes |
| 885 | 2330 | 2330.0 | 152.59 | 152.6 | Obesity: global epidemiology and pathogenesis. | Matthias Blüher | Nat Rev Endocrinol | 2019 | 30814686 | No |
| 886 | 2329 | 2329.0 | 56.82 | 56.8 | P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation. | Berk Hess | J Chem Theory Comput | 2008 | 26619985 | Yes |
| 887 | 4654 | 2327.0 | 87.65 | 43.8 | A novel genetic system to detect protein-protein interactions. | S Fields, O Song | Nature | 1989 | 2547163 | Yes |
| 888 | 2327 | 2327.0 | 77.71 | 77.7 | Simplified calculation of body-surface area. | R D Mosteller | N Engl J Med | 1987 | 3657876 | Yes |
| 889 | 2327 | 2327.0 | 59.25 | 59.2 | Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. | R D Pascual-Marqui | Methods Find Exp Clin Pharmacol | 2002 | 12575463 | No |
| 890 | 2325 | 2325.0 | 84.24 | 84.2 | Calmodulin plays a pivotal role in cellular regulation. | W Y Cheung | Science | 1980 | 6243188 | No |
| 891 | 4649 | 2324.5 | 122.43 | 61.2 | Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. | C W Elston, I O Ellis | Histopathology | 1991 | 1757079 | Yes |
| 892 | 2324 | 2324.0 | 66.17 | 66.2 | Interleukin-1 and interleukin-1 antagonism. | C A Dinarello | Blood | 1991 | 1826616 | No |
| 893 | 2324 | 2324.0 | 57.13 | 57.1 | Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. | Jane Glazebrook | Annu Rev Phytopathol | 2005 | 16078883 | No |
| 894 | 2324 | 2324.0 | 111.06 | 111.1 | Abiotic Stress Signaling and Responses in Plants. | Jian-Kang Zhu | Cell | 2016 | 27716505 | No |
| 895 | 2323 | 2323.0 | 41.96 | 42.0 | Stereochemistry of cooperative effects in haemoglobin. | M F Perutz | Nature | 1970 | 5528785 | Yes |
| 896 | 2322 | 2322.0 | 55.43 | 55.4 | Ischemic cell death in brain neurons. | P Lipton | Physiol Rev | 1999 | 10508238 | No |
| 897 | 4642 | 2321.0 | 113.4 | 56.7 | Nonparametric permutation tests for functional neuroimaging: a primer with examples. | Thomas E Nichols, Andrew P Holmes | Hum Brain Mapp | 2002 | 11747097 | Yes |
| 898 | 2320 | 2320.0 | 57.37 | 57.4 | A model for receptor-regulated calcium entry. | J W Putney | Cell Calcium | 1986 | 2420465 | No |
| 899 | 4640 | 2320.0 | 124.01 | 62.0 | Application of phylogenetic networks in evolutionary studies. | Daniel H Huson, David Bryant | Mol Biol Evol | 2006 | 16221896 | Yes |
| 900 | 2320 | 2320.0 | 65.32 | 65.3 | TGFβ signalling in context. | Joan Massagué | Nat Rev Mol Cell Biol | 2012 | 22992590 | No |
| 901 | 2319 | 2319.0 | 78.85 | 78.8 | Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. | F F Jöbsis | Science | 1977 | 929199 | Yes |
| 902 | 4638 | 2319.0 | 130.37 | 65.2 | Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. | R A Laskey, A D Mills | Eur J Biochem | 1975 | 1175627 | Yes |
| 903 | 2319 | 2319.0 | 50.01 | 50.0 | Nitric oxide and the immune response. | C Bogdan | Nat Immunol | 2001 | 11577346 | No |
| 904 | 2318 | 2318.0 | 75.5 | 75.5 | Qualitative research: standards, challenges, and guidelines. | K Malterud | Lancet | 2001 | 11513933 | Yes |
| 905 | 2318 | 2318.0 | 0.0 | 0.0 | Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. | G Bertani | J Bacteriol | 1951 | 14888646 | Yes |
| 906 | 2318 | 2318.0 | 48.84 | 48.8 | NOX enzymes and the biology of reactive oxygen. | J David Lambeth | Nat Rev Immunol | 2004 | 15039755 | No |
| 907 | 4631 | 2315.5 | 89.76 | 44.9 | Mechanisms of TGF-beta signaling from cell membrane to the nucleus. | Yigong Shi, Joan Massagué | Cell | 2003 | 12809600 | No |
| 908 | 2313 | 2313.0 | 79.42 | 79.4 | Large-scale brain networks and psychopathology: a unifying triple network model. | Vinod Menon | Trends Cogn Sci | 2011 | 21908230 | No |
| 909 | 9246 | 2311.5 | 201.52 | 50.4 | Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. | A Krogh, B Larsson, G von Heijne, E L Sonnhammer | J Mol Biol | 2001 | 11152613 | Yes |
| 910 | 2309 | 2309.0 | 53.46 | 53.5 | Specification of cerebral cortical areas. | P Rakic | Science | 1988 | 3291116 | No |
| 911 | 2308 | 2308.0 | 55.74 | 55.7 | The anatomy and taxonomy of protein structure. | J S Richardson | Adv Protein Chem | 1981 | 7020376 | No |
| 912 | 2306 | 2306.0 | 27.34 | 27.3 | Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. | T Higuchi | J Pharm Sci | 1963 | 14088963 | Yes |
| 913 | 4609 | 2304.5 | 73.76 | 36.9 | On the size of the active site in proteases. I. Papain. | I Schechter, A Berger | Biochem Biophys Res Commun | 1967 | 6035483 | Yes |
| 914 | 2304 | 2304.0 | 65.82 | 65.8 | Inositol phospholipids and cell surface receptor function. | R H Michell | Biochim Biophys Acta | 1975 | 164246 | No |
| 915 | 4602 | 2301.0 | 72.03 | 36.0 | High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. | M N Berry, D S Friend | J Cell Biol | 1969 | 4900611 | Yes |
| 916 | 4599 | 2299.5 | 123.62 | 61.8 | A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. | Y Matsumura, H Maeda | Cancer Res | 1986 | 2946403 | Yes |
| 917 | 2298 | 2298.0 | 56.97 | 57.0 | Bcl-2 and the regulation of programmed cell death. | J C Reed | J Cell Biol | 1994 | 8294493 | No |
| 918 | 2298 | 2298.0 | 71.78 | 71.8 | Human error: models and management. | J Reason | BMJ | 2000 | 10720363 | Yes |
| 919 | 4591 | 2295.5 | 168.3 | 84.2 | The attention system of the human brain. | M I Posner, S E Petersen | Annu Rev Neurosci | 1990 | 2183676 | No |
| 920 | 4586 | 2293.0 | 86.58 | 43.3 | The interpretation of protein structures: estimation of static accessibility. | B Lee, F M Richards | J Mol Biol | 1971 | 5551392 | Yes |
| 921 | 4584 | 2292.0 | 115.23 | 57.6 | A receptor-mediated pathway for cholesterol homeostasis. | M S Brown, J L Goldstein | Science | 1986 | 3513311 | No |
| 922 | 4580 | 2290.0 | 107.01 | 53.5 | Protein misfolding, functional amyloid, and human disease. | Fabrizio Chiti, Christopher M Dobson | Annu Rev Biochem | 2006 | 16756495 | No |
| 923 | 2290 | 2290.0 | 58.61 | 58.6 | The blood-brain barrier in health and chronic neurodegenerative disorders. | Berislav V Zlokovic | Neuron | 2008 | 18215617 | No |
| 924 | 2289 | 2289.0 | 60.19 | 60.2 | The importance of selenium to human health. | M P Rayman | Lancet | 2000 | 10963212 | No |
| 925 | 4578 | 2289.0 | 338.55 | 169.3 | The biology, function, and biomedical applications of exosomes. | Raghu Kalluri, Valerie S LeBleu | Science | 2020 | 32029601 | No |
| 926 | 2287 | 2287.0 | 72.73 | 72.7 | Spinal and supraspinal factors in human muscle fatigue. | S C Gandevia | Physiol Rev | 2001 | 11581501 | No |
| 927 | 2287 | 2287.0 | 95.08 | 95.1 | What's in a name? Qualitative description revisited. | Margarete Sandelowski | Res Nurs Health | 2010 | 20014004 | Yes |
| 928 | 2286 | 2286.0 | 105.17 | 105.2 | Metazoan MicroRNAs. | David P Bartel | Cell | 2018 | 29570994 | No |
| 929 | 2282 | 2282.0 | 74.48 | 74.5 | Eye movements in reading and information processing: 20 years of research. | K Rayner | Psychol Bull | 1998 | 9849112 | No |
| 930 | 2282 | 2282.0 | 55.71 | 55.7 | Animal mitochondrial genomes. | J L Boore | Nucleic Acids Res | 1999 | 10101183 | No |
| 931 | 2281 | 2281.0 | 71.15 | 71.2 | Reactive oxygen species and the central nervous system. | B Halliwell | J Neurochem | 1992 | 1402908 | No |
| 932 | 2281 | 2281.0 | 45.21 | 45.2 | SV40-transformed simian cells support the replication of early SV40 mutants. | Y Gluzman | Cell | 1981 | 6260373 | Yes |
| 933 | 2278 | 2278.0 | 42.72 | 42.7 | Histone acetylation in chromatin structure and transcription. | M Grunstein | Nature | 1997 | 9311776 | No |
| 934 | 2275 | 2275.0 | 76.2 | 76.2 | Glutamate, nitric oxide and cell-cell signalling in the nervous system. | J Garthwaite | Trends Neurosci | 1991 | 1708538 | No |
| 935 | 4549 | 2274.5 | 94.96 | 47.5 | Mass spectrometry-based proteomics. | Ruedi Aebersold, Matthias Mann | Nature | 2003 | 12634793 | No |
| 936 | 2273 | 2273.0 | 60.09 | 60.1 | Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. | Claudiu T Supuran | Nat Rev Drug Discov | 2008 | 18167490 | No |
| 937 | 2266 | 2266.0 | 59.5 | 59.5 | Epidemiology of insomnia: what we know and what we still need to learn. | Maurice M Ohayon | Sleep Med Rev | 2002 | 12531146 | Yes |
| 938 | 2264 | 2264.0 | 65.77 | 65.8 | Social determinants of health inequalities. | Michael Marmot | Lancet | 2005 | 15781105 | Yes |
| 939 | 2263 | 2263.0 | 48.85 | 48.9 | Chemokines and leukocyte traffic. | M Baggiolini | Nature | 1998 | 9560152 | No |
| 940 | 2263 | 2263.0 | 0.0 | 0.0 | [Rapid physiological coagulation method in determination of fibrinogen]. | A Clauss | Acta Haematol | 1957 | 13434757 | Yes |
| 941 | 2263 | 2263.0 | 133.57 | 133.6 | Toward understanding the origin and evolution of cellular organisms. | Minoru Kanehisa | Protein Sci | 2019 | 31441146 | No |
| 942 | 4525 | 2262.5 | 129.14 | 64.6 | Distributed hierarchical processing in the primate cerebral cortex. | D J Felleman, D C Van Essen | Cereb Cortex | 1991 | 1822724 | No |
| 943 | 2262 | 2262.0 | 65.52 | 65.5 | Hazards of heavy metal contamination. | Lars Järup | Br Med Bull | 2003 | 14757716 | No |
| 944 | 2262 | 2262.0 | 67.36 | 67.4 | PsychoPy--Psychophysics software in Python. | Jonathan W Peirce | J Neurosci Methods | 2007 | 17254636 | Yes |
| 945 | 2260 | 2260.0 | 50.97 | 51.0 | Application of a microtechnique to viral serological investigations. | J L Sever | J Immunol | 1962 | 13910995 | Yes |
| 946 | 4520 | 2260.0 | 100.94 | 50.5 | Brown adipose tissue: function and physiological significance. | Barbara Cannon, Jan Nedergaard | Physiol Rev | 2004 | 14715917 | No |
| 947 | 2259 | 2259.0 | 44.34 | 44.3 | The molecular biology of memory storage: a dialogue between genes and synapses. | E R Kandel | Science | 2001 | 11691980 | No |
| 948 | 2259 | 2259.0 | 58.52 | 58.5 | Working memory: looking back and looking forward. | Alan Baddeley | Nat Rev Neurosci | 2003 | 14523382 | No |
| 949 | 4518 | 2259.0 | 115.83 | 57.9 | ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. | B Ravel, M Newville | J Synchrotron Radiat | 2005 | 15968136 | Yes |
| 950 | 2258 | 2258.0 | 116.43 | 116.4 | Electroimmuno assay. | C B Laurell | Scand J Clin Lab Invest Suppl | 1972 | 4114358 | Yes |
| 951 | 2254 | 2254.0 | 68.7 | 68.7 | Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. | R A DeFronzo | Diabetes | 1988 | 3289989 | No |
| 952 | 2249 | 2249.0 | 140.53 | 140.5 | Presidential Address-1976. Social support as a moderator of life stress. | S Cobb | Psychosom Med | 1976 | 981490 | Yes |
| 953 | 4495 | 2247.5 | 102.9 | 51.5 | A simple and very efficient method for generating cDNA libraries. | U Gubler, B J Hoffman | Gene | 1983 | 6198242 | Yes |
| 954 | 2247 | 2247.0 | 84.14 | 84.1 | Specific impairments of planning. | T Shallice | Philos Trans R Soc Lond B Biol Sci | 1982 | 6125971 | Yes |
| 955 | 2247 | 2247.0 | 55.96 | 56.0 | RGD and other recognition sequences for integrins. | E Ruoslahti | Annu Rev Cell Dev Biol | 1996 | 8970741 | No |
| 956 | 2244 | 2244.0 | 53.18 | 53.2 | Protein kinase C and lipid signaling for sustained cellular responses. | Y Nishizuka | FASEB J | 1995 | 7737456 | No |
| 957 | 2244 | 2244.0 | 70.54 | 70.5 | Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. | W A Craig | Clin Infect Dis | 1998 | 9455502 | No |
| 958 | 2241 | 2241.0 | 61.24 | 61.2 | Molecular diversity of glutamate receptors and implications for brain function. | S Nakanishi | Science | 1992 | 1329206 | No |
| 959 | 4480 | 2240.0 | 107.93 | 54.0 | Regulation of the mevalonate pathway. | J L Goldstein, M S Brown | Nature | 1990 | 1967820 | No |
| 960 | 4480 | 2240.0 | 114.05 | 57.0 | Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. | M Matsuda, R A DeFronzo | Diabetes Care | 1999 | 10480510 | Yes |
| 961 | 8949 | 2237.2 | 181.04 | 45.3 | WebLogo: a sequence logo generator. | Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E Brenner | Genome Res | 2004 | 15173120 | Yes |
| 962 | 4474 | 2237.0 | 88.63 | 44.3 | The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. | J A Spudich, S Watt | J Biol Chem | 1971 | 4254541 | Yes |
| 963 | 2237 | 2237.0 | 54.88 | 54.9 | Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. | J Kyhse-Andersen | J Biochem Biophys Methods | 1984 | 6530509 | Yes |
| 964 | 2236 | 2236.0 | 41.73 | 41.7 | Shelterin: the protein complex that shapes and safeguards human telomeres. | Titia de Lange | Genes Dev | 2005 | 16166375 | No |
| 965 | 4471 | 2235.5 | 88.06 | 44.0 | Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. | T V Bliss, T Lomo | J Physiol | 1973 | 4727084 | Yes |
| 966 | 2235 | 2235.0 | 109.36 | 109.4 | Mechanisms of action of transmitters and other substances on smooth muscle. | T B Bolton | Physiol Rev | 1979 | 37533 | No |
| 967 | 2235 | 2235.0 | 57.28 | 57.3 | Pancreatic cancer. | Manuel Hidalgo | N Engl J Med | 2010 | 20427809 | No |
| 968 | 4466 | 2233.0 | 39.27 | 19.6 | A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. | J E TILL, E A McCULLOCH | Radiat Res | 1961 | 13776896 | Yes |
| 969 | 2232 | 2232.0 | 77.22 | 77.2 | Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. | B N Ames | Science | 1983 | 6351251 | No |
| 970 | 4463 | 2231.5 | 128.95 | 64.5 | Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9167458 | Yes |
| 971 | 13387 | 2231.2 | 712.6 | 118.8 | DADA2: High-resolution sample inference from Illumina amplicon data. | Benjamin J Callahan, Paul J McMurdie, Michael J Rosen, Andrew W Han, Amy Jo A Johnson, Susan P Holmes | Nat Methods | 2016 | 27214047 | Yes |
| 972 | 17840 | 2230.0 | 561.55 | 70.2 | The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. | D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C Siebert | N Engl J Med | 1993 | 8366922 | Yes |
| 973 | 2224 | 2224.0 | 68.5 | 68.5 | Biodiesel from microalgae. | Yusuf Chisti | Biotechnol Adv | 2007 | 17350212 | No |
| 974 | 4447 | 2223.5 | 98.11 | 49.1 | Organization and expression of eucaryotic split genes coding for proteins. | R Breathnach, P Chambon | Annu Rev Biochem | 1981 | 6791577 | No |
| 975 | 2223 | 2223.0 | 49.05 | 49.0 | The regulation of AP-1 activity by mitogen-activated protein kinases. | M Karin | J Biol Chem | 1995 | 7622446 | No |
| 976 | 2221 | 2221.0 | 52.54 | 52.5 | Mechanisms and genes of cellular suicide. | H Steller | Science | 1995 | 7878463 | No |
| 977 | 19988 | 2220.9 | 917.65 | 102.0 | Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. | Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray | Int J Cancer | 2015 | 25220842 | Yes |
| 978 | 2219 | 2219.0 | 59.88 | 59.9 | Biofilms: microbial life on surfaces. | Rodney M Donlan | Emerg Infect Dis | 2002 | 12194761 | No |
| 979 | 6644 | 2214.7 | 255.66 | 85.2 | Glucose clamp technique: a method for quantifying insulin secretion and resistance. | R A DeFronzo, J D Tobin, R Andres | Am J Physiol | 1979 | 382871 | Yes |
| 980 | 2213 | 2213.0 | 89.61 | 89.6 | Role of Streptococcus mutans in human dental decay. | W J Loesche | Microbiol Rev | 1986 | 3540569 | No |
| 981 | 2211 | 2211.0 | 87.44 | 87.4 | Approximate entropy as a measure of system complexity. | S M Pincus | Proc Natl Acad Sci U S A | 1991 | 11607165 | Yes |
| 982 | 2210 | 2210.0 | 48.84 | 48.8 | Intracellular aspects of the process of protein synthesis. | G Palade | Science | 1975 | 1096303 | No |
| 983 | 2210 | 2210.0 | 71.94 | 71.9 | Keratoconus. | Y S Rabinowitz | Surv Ophthalmol | 1998 | 9493273 | No |
| 984 | 6629 | 2209.7 | 183.1 | 61.0 | Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. | F E Harrell, K L Lee, D B Mark | Stat Med | 1996 | 8668867 | No |
| 985 | 2209 | 2209.0 | 65.49 | 65.5 | Diagnosis of Alzheimer's disease. | Z S Khachaturian | Arch Neurol | 1985 | 2864910 | Yes |
| 986 | 2208 | 2208.0 | 61.97 | 62.0 | Infrared spectroscopy of proteins. | Andreas Barth | Biochim Biophys Acta | 2007 | 17692815 | No |
| 987 | 4415 | 2207.5 | 99.0 | 49.5 | The Bcl-2 protein family: arbiters of cell survival. | J M Adams, S Cory | Science | 1998 | 9735050 | No |
| 988 | 2205 | 2205.0 | 83.73 | 83.7 | Role of endothelium in responses of vascular smooth muscle. | R F Furchgott | Circ Res | 1983 | 6313250 | No |
| 989 | 2205 | 2205.0 | 63.22 | 63.2 | Hypoxia-inducible factors in physiology and medicine. | Gregg L Semenza | Cell | 2012 | 22304911 | No |
| 990 | 2201 | 2201.0 | 61.58 | 61.6 | Hybrid porous solids: past, present, future. | Gérard Férey | Chem Soc Rev | 2008 | 18197340 | Yes |
| 991 | 2200 | 2200.0 | 87.88 | 87.9 | Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. | Konrad M Andrassy | Kidney Int | 2013 | 23989362 | Yes |
| 992 | 2199 | 2199.0 | 55.03 | 55.0 | Removal of fatty acids from serum albumin by charcoal treatment. | R F Chen | J Biol Chem | 1967 | 6016603 | Yes |
| 993 | 2197 | 2197.0 | 46.87 | 46.9 | Complement. First of two parts. | M J Walport | N Engl J Med | 2001 | 11287977 | No |
| 994 | 2196 | 2196.0 | 68.08 | 68.1 | Prooxidant states and tumor promotion. | P A Cerutti | Science | 1985 | 2981433 | No |
| 995 | 4391 | 2195.5 | 95.56 | 47.8 | Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. | F Sallusto, A Lanzavecchia | J Exp Med | 1994 | 8145033 | Yes |
| 996 | 8775 | 2193.8 | 187.83 | 47.0 | MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. | Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi Miyata | Nucleic Acids Res | 2002 | 12136088 | Yes |
| 997 | 2193 | 2193.0 | 48.62 | 48.6 | Chemokines. | B J Rollins | Blood | 1997 | 9242519 | No |
| 998 | 4385 | 2192.5 | 545.95 | 273.0 | Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2021 | 33885785 | Yes |
| 999 | 6577 | 2192.3 | 194.82 | 64.9 | The brain's default network: anatomy, function, and relevance to disease. | Randy L Buckner, Jessica R Andrews-Hanna, Daniel L Schacter | Ann N Y Acad Sci | 2008 | 18400922 | No |
| 1000 | 2192 | 2192.0 | 78.99 | 79.0 | Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. | H W Steinbusch | Neuroscience | 1981 | 7017455 | Yes |
| 1001 | 2191 | 2191.0 | 53.83 | 53.8 | Using circular dichroism spectra to estimate protein secondary structure. | Norma J Greenfield | Nat Protoc | 2006 | 17406547 | Yes |
| 1002 | 4380 | 2190.0 | 105.32 | 52.7 | Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. | Michael T Lin, M Flint Beal | Nature | 2006 | 17051205 | No |
| 1003 | 4378 | 2189.0 | 76.37 | 38.2 | Variations in pattern of pubertal changes in girls. | W A Marshall, J M Tanner | Arch Dis Child | 1969 | 5785179 | Yes |
| 1004 | 2189 | 2189.0 | 56.05 | 56.0 | The physiology of glucagon-like peptide 1. | Jens Juul Holst | Physiol Rev | 2007 | 17928588 | No |
| 1005 | 2188 | 2188.0 | 54.41 | 54.4 | The extracellular matrix: not just pretty fibrils. | Richard O Hynes | Science | 2009 | 19965464 | No |
| 1006 | 6562 | 2187.3 | 204.83 | 68.3 | Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. | R L Spitzer, K Kroenke, J B Williams | JAMA | 1999 | 10568646 | Yes |
| 1007 | 4373 | 2186.5 | 148.08 | 74.0 | Shifting the genomic gold standard for the prokaryotic species definition. | Michael Richter, Ramon Rosselló-Móra | Proc Natl Acad Sci U S A | 2009 | 19855009 | Yes |
| 1008 | 2186 | 2186.0 | 52.79 | 52.8 | Breast cancer and hormone-replacement therapy in the Million Women Study. | Valerie Beral | Lancet | 2003 | 12927427 | Yes |
| 1009 | 2182 | 2182.0 | 66.33 | 66.3 | Fetal origins of coronary heart disease. | D J Barker | BMJ | 1995 | 7613432 | No |
| 1010 | 2181 | 2181.0 | 90.68 | 90.7 | A systematic method for clinical description and classification of personality variants. A proposal. | C R Cloninger | Arch Gen Psychiatry | 1987 | 3579504 | Yes |
| 1011 | 2181 | 2181.0 | 58.85 | 58.9 | The episodic buffer: a new component of working memory? | A Baddeley | Trends Cogn Sci | 2000 | 11058819 | Yes |
| 1012 | 4360 | 2180.0 | 0.0 | 0.0 | Loss of recent memory after bilateral hippocampal lesions. | W B Scoville, B Milner | J Neurol Neurosurg Psychiatry | 1957 | 13406589 | Yes |
| 1013 | 8718 | 2179.5 | 209.24 | 52.3 | Matrix elasticity directs stem cell lineage specification. | Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E Discher | Cell | 2006 | 16923388 | Yes |
| 1014 | 4357 | 2178.5 | 103.46 | 51.7 | Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. | Hashem B El-Serag, K Lenhard Rudolph | Gastroenterology | 2007 | 17570226 | No |
| 1015 | 2175 | 2175.0 | 48.38 | 48.4 | A clearer vision for in vivo imaging. | R Weissleder | Nat Biotechnol | 2001 | 11283581 | No |
| 1016 | 2175 | 2175.0 | 69.95 | 70.0 | Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. | Peter C Austin | Pharm Stat | 2011 | 20925139 | Yes |
| 1017 | 2169 | 2169.0 | 56.51 | 56.5 | The molecular pathology of Alzheimer's disease. | D J Selkoe | Neuron | 1991 | 1673054 | No |
| 1018 | 2167 | 2167.0 | 60.17 | 60.2 | Superoxide radical and superoxide dismutases. | I Fridovich | Annu Rev Biochem | 1995 | 7574505 | No |
| 1019 | 2166 | 2166.0 | 65.69 | 65.7 | Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. | Leonardo Pantoni | Lancet Neurol | 2010 | 20610345 | No |
| 1020 | 34653 | 2165.8 | 1111.71 | 69.5 | Fiji: an open-source platform for biological-image analysis. | Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert Cardona | Nat Methods | 2012 | 22743772 | Yes |
| 1021 | 4325 | 2162.5 | 148.74 | 74.4 | Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. | R B Devereux, N Reichek | Circulation | 1977 | 138494 | Yes |
| 1022 | 2162 | 2162.0 | 78.35 | 78.3 | UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. | D W Russell | J Pers Assess | 1996 | 8576833 | Yes |
| 1023 | 2162 | 2162.0 | 55.03 | 55.0 | Descending control of pain. | Mark J Millan | Prog Neurobiol | 2002 | 12034378 | No |
| 1024 | 2158 | 2158.0 | 71.11 | 71.1 | A classification of glycosyl hydrolases based on amino acid sequence similarities. | B Henrissat | Biochem J | 1991 | 1747104 | Yes |
| 1025 | 2158 | 2158.0 | 41.82 | 41.8 | Protein modules and signalling networks. | T Pawson | Nature | 1995 | 7531822 | No |
| 1026 | 4314 | 2157.0 | 182.04 | 91.0 | The Health Belief Model: a decade later. | N K Janz, M H Becker | Health Educ Q | 1984 | 6392204 | No |
| 1027 | 2154 | 2154.0 | 93.17 | 93.2 | The Children's Depression, Inventory (CDI). | M Kovacs | Psychopharmacol Bull | 1985 | 4089116 | Yes |
| 1028 | 2152 | 2152.0 | 31.2 | 31.2 | Sedimentation Studies Of The Size And Shape Of Dna. | F W Studier | J Mol Biol | 1965 | 14290352 | Yes |
| 1029 | 6454 | 2151.3 | 186.31 | 62.1 | Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. | C E Murry, R B Jennings, K A Reimer | Circulation | 1986 | 3769170 | Yes |
| 1030 | 2151 | 2151.0 | 45.8 | 45.8 | Theta oscillations in the hippocampus. | György Buzsáki | Neuron | 2002 | 11832222 | No |
| 1031 | 2150 | 2150.0 | 0.0 | 0.0 | Analysis of tissue and arterial blood temperatures in the resting human forearm. | H H Pennes | J Appl Physiol | 1948 | 18887578 | Yes |
| 1032 | 2149 | 2149.0 | 39.98 | 40.0 | NK cell recognition. | Lewis L Lanier | Annu Rev Immunol | 2005 | 15771571 | No |
| 1033 | 4298 | 2149.0 | 111.62 | 55.8 | The inflammasomes. | Kate Schroder, Jurg Tschopp | Cell | 2010 | 20303873 | No |
| 1034 | 12882 | 2147.0 | 287.84 | 48.0 | NMRPipe: a multidimensional spectral processing system based on UNIX pipes. | F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A Bax | J Biomol NMR | 1995 | 8520220 | Yes |
| 1035 | 2146 | 2146.0 | 115.82 | 115.8 | The assessment of clinical skills/competence/performance. | G E Miller | Acad Med | 1990 | 2400509 | Yes |
| 1036 | 2146 | 2146.0 | 49.59 | 49.6 | Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. | G Trinchieri | Annu Rev Immunol | 1995 | 7612223 | No |
| 1037 | 2145 | 2145.0 | 48.56 | 48.6 | Comparison of the predicted and observed secondary structure of T4 phage lysozyme. | B W Matthews | Biochim Biophys Acta | 1975 | 1180967 | Yes |
| 1038 | 2145 | 2145.0 | 51.51 | 51.5 | Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. | Edward V Loftus | Gastroenterology | 2004 | 15168363 | Yes |
| 1039 | 2145 | 2145.0 | 48.71 | 48.7 | Pathways towards and away from Alzheimer's disease. | Mark P Mattson | Nature | 2004 | 15295589 | No |
| 1040 | 6434 | 2144.7 | 131.58 | 43.9 | EMBOSS: the European Molecular Biology Open Software Suite. | P Rice, I Longden, A Bleasby | Trends Genet | 2000 | 10827456 | Yes |
| 1041 | 4288 | 2144.0 | 117.09 | 58.5 | Autophagy: renovation of cells and tissues. | Noboru Mizushima, Masaaki Komatsu | Cell | 2011 | 22078875 | No |
| 1042 | 4282 | 2141.0 | 100.46 | 50.2 | Assembly of asparagine-linked oligosaccharides. | R Kornfeld, S Kornfeld | Annu Rev Biochem | 1985 | 3896128 | No |
| 1043 | 2140 | 2140.0 | 0.0 | 0.0 | A new specific color reaction of hexuronic acids. | Z Dische | J Biol Chem | 1947 | 20281638 | Yes |
| 1044 | 4277 | 2138.5 | 73.4 | 36.7 | A Simplified Lead Citrate Stain For Use In Electron Microscopy. | J H Venable, R Coggeshall | J Cell Biol | 1965 | 14287192 | Yes |
| 1045 | 6414 | 2138.0 | 195.46 | 65.2 | Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. | Aleksandr V Marenich, Christopher J Cramer, Donald G Truhlar | J Phys Chem B | 2009 | 19366259 | Yes |
| 1046 | 4275 | 2137.5 | 103.49 | 51.7 | Measuring the thickness of the human cerebral cortex from magnetic resonance images. | B Fischl, A M Dale | Proc Natl Acad Sci U S A | 2000 | 10984517 | Yes |
| 1047 | 4272 | 2136.0 | 106.87 | 53.4 | Function and activation of NF-kappa B in the immune system. | P A Baeuerle, T Henkel | Annu Rev Immunol | 1994 | 8011280 | No |
| 1048 | 6404 | 2134.7 | 131.25 | 43.8 | Immunochemical quantitation of antigens by single radial immunodiffusion. | G Mancini, A O Carbonara, J F Heremans | Immunochemistry | 1965 | 4956917 | Yes |
| 1049 | 4269 | 2134.5 | 80.43 | 40.2 | The fundamental role of epigenetic events in cancer. | Peter A Jones, Stephen B Baylin | Nat Rev Genet | 2002 | 12042769 | No |
| 1050 | 2134 | 2134.0 | 64.71 | 64.7 | The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. | D E Atkinson | Biochemistry | 1968 | 4972613 | Yes |
| 1051 | 4268 | 2134.0 | 83.19 | 41.6 | Smad-dependent and Smad-independent pathways in TGF-beta family signalling. | Rik Derynck, Ying E Zhang | Nature | 2003 | 14534577 | No |
| 1052 | 4268 | 2134.0 | 149.44 | 74.7 | Deciphering key features in protein structures with the new ENDscript server. | Xavier Robert, Patrice Gouet | Nucleic Acids Res | 2014 | 24753421 | Yes |
| 1053 | 2131 | 2131.0 | 49.47 | 49.5 | Metabolomics--the link between genotypes and phenotypes. | Oliver Fiehn | Plant Mol Biol | 2002 | 11860207 | No |
| 1054 | 2129 | 2129.0 | 59.04 | 59.0 | Japanese Classification of Gastric Carcinoma - 2nd English Edition - | Japanese Gastric Cancer Association | Gastric Cancer | 1998 | 11957040 | Yes |
| 1055 | 4256 | 2128.0 | 127.75 | 63.9 | Macrophage plasticity and polarization: in vivo veritas. | Antonio Sica, Alberto Mantovani | J Clin Invest | 2012 | 22378047 | No |
| 1056 | 6382 | 2127.3 | 146.26 | 48.8 | MOLMOL: a program for display and analysis of macromolecular structures. | R Koradi, M Billeter, K Wüthrich | J Mol Graph | 1996 | 8744573 | Yes |
| 1057 | 6381 | 2127.0 | 161.39 | 53.8 | GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. | R A Jefferson, T A Kavanagh, M W Bevan | EMBO J | 1987 | 3327686 | Yes |
| 1058 | 4254 | 2127.0 | 122.43 | 61.2 | Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. | J S Beckman, W H Koppenol | Am J Physiol | 1996 | 8944624 | No |
| 1059 | 2127 | 2127.0 | 42.12 | 42.1 | Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. | Shimon Sakaguchi | Nat Immunol | 2005 | 15785760 | No |
| 1060 | 4253 | 2126.5 | 135.03 | 67.5 | A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. | Gary J Bennett, Y-K Xie | Pain | 1988 | 2837713 | Yes |
| 1061 | 6378 | 2126.0 | 149.49 | 49.8 | APE: Analyses of Phylogenetics and Evolution in R language. | Emmanuel Paradis, Julien Claude, Korbinian Strimmer | Bioinformatics | 2004 | 14734327 | Yes |
| 1062 | 8495 | 2123.8 | 536.27 | 134.1 | Rayyan-a web and mobile app for systematic reviews. | Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz, Ahmed Elmagarmid | Syst Rev | 2016 | 27919275 | Yes |
| 1063 | 4239 | 2119.5 | 82.73 | 41.4 | Network biology: understanding the cell's functional organization. | Albert-László Barabási, Zoltán N Oltvai | Nat Rev Genet | 2004 | 14735121 | No |
| 1064 | 6358 | 2119.3 | 280.53 | 93.5 | Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. | B N Ames, J Mccann, E Yamasaki | Mutat Res | 1975 | 768755 | Yes |
| 1065 | 2114 | 2114.0 | 63.97 | 64.0 | The unbiased estimation of number and sizes of arbitrary particles using the disector. | D C Sterio | J Microsc | 1984 | 6737468 | Yes |
| 1066 | 4226 | 2113.0 | 121.42 | 60.7 | Angiogenic factors. | J Folkman, M Klagsbrun | Science | 1987 | 2432664 | No |
| 1067 | 2113 | 2113.0 | 35.24 | 35.2 | Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. | D Aminoff | Biochem J | 1961 | 13860975 | Yes |
| 1068 | 6339 | 2113.0 | 278.2 | 92.7 | Fast and sensitive protein alignment using DIAMOND. | Benjamin Buchfink, Chao Xie, Daniel H Huson | Nat Methods | 2015 | 25402007 | Yes |
| 1069 | 6335 | 2111.7 | 118.0 | 39.3 | Control of regulatory T cell development by the transcription factor Foxp3. | Shohei Hori, Takashi Nomura, Shimon Sakaguchi | Science | 2003 | 12522256 | Yes |
| 1070 | 2110 | 2110.0 | 44.52 | 44.5 | Mammalian G1 cyclins. | C J Sherr | Cell | 1993 | 8513492 | No |
| 1071 | 2110 | 2110.0 | 50.88 | 50.9 | Dopamine, learning and motivation. | Roy A Wise | Nat Rev Neurosci | 2004 | 15152198 | No |
| 1072 | 4214 | 2107.0 | 178.92 | 89.5 | The MOS social support survey. | C D Sherbourne, A L Stewart | Soc Sci Med | 1991 | 2035047 | Yes |
| 1073 | 4212 | 2106.0 | 106.89 | 53.4 | Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. | E Lander, L Kruglyak | Nat Genet | 1995 | 7581446 | Yes |
| 1074 | 2104 | 2104.0 | 38.08 | 38.1 | Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. | P Mitchell | Biol Rev Camb Philos Soc | 1966 | 5329743 | No |
| 1075 | 2102 | 2102.0 | 60.63 | 60.6 | The plasma lecithins:cholesterol acyltransferase reaction. | J A Glomset | J Lipid Res | 1968 | 4868699 | No |
| 1076 | 2101 | 2101.0 | 74.74 | 74.7 | International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. | C Herrmann | J Psychosom Res | 1997 | 9055211 | No |
| 1077 | 2100 | 2100.0 | 52.43 | 52.4 | Accurate description of van der Waals complexes by density functional theory including empirical corrections. | Stefan Grimme | J Comput Chem | 2004 | 15224390 | Yes |
| 1078 | 2097 | 2097.0 | 42.44 | 42.4 | Role of angiogenesis in tumor growth and metastasis. | Judah Folkman | Semin Oncol | 2002 | 12516034 | No |
| 1079 | 2097 | 2097.0 | 47.44 | 47.4 | Follicular helper CD4 T cells (TFH). | Shane Crotty | Annu Rev Immunol | 2011 | 21314428 | No |
| 1080 | 2096 | 2096.0 | 49.38 | 49.4 | Patterns of amino acids near signal-sequence cleavage sites. | G von Heijne | Eur J Biochem | 1983 | 6852022 | Yes |
| 1081 | 2093 | 2093.0 | 83.47 | 83.5 | A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. | E L Bradley | Arch Surg | 1993 | 8489394 | No |
| 1082 | 4182 | 2091.0 | 120.64 | 60.3 | Oncology meets immunology: the cancer-immunity cycle. | Daniel S Chen, Ira Mellman | Immunity | 2013 | 23890059 | No |
| 1083 | 8353 | 2088.2 | 397.87 | 99.5 | The Satisfaction With Life Scale. | E Diener, R A Emmons, R J Larsen, S Griffin | J Pers Assess | 1985 | 16367493 | Yes |
| 1084 | 8344 | 2086.0 | 303.62 | 75.9 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | J Clin Epidemiol | 2009 | 19631508 | No |
| 1085 | 2086 | 2086.0 | 94.11 | 94.1 | The brain's default mode network. | Marcus E Raichle | Annu Rev Neurosci | 2015 | 25938726 | No |
| 1086 | 4167 | 2083.5 | 109.07 | 54.5 | The heat-shock proteins. | S Lindquist, E A Craig | Annu Rev Genet | 1988 | 2853609 | No |
| 1087 | 6247 | 2082.3 | 185.73 | 61.9 | Arlequin (version 3.0): an integrated software package for population genetics data analysis. | Laurent Excoffier, Guillaume Laval, Stefan Schneider | Evol Bioinform Online | 2007 | 19325852 | Yes |
| 1088 | 2081 | 2081.0 | 94.01 | 94.0 | Method For Assay Of Intestinal Disaccharidases. | A Dahlqvist | Anal Biochem | 1964 | 14106916 | Yes |
| 1089 | 2080 | 2080.0 | 45.29 | 45.3 | Defensins: antimicrobial peptides of innate immunity. | Tomas Ganz | Nat Rev Immunol | 2003 | 12949495 | No |
| 1090 | 2078 | 2078.0 | 71.82 | 71.8 | Purinergic nerves. | G Burnstock | Pharmacol Rev | 1972 | 4404211 | No |
| 1091 | 4155 | 2077.5 | 185.47 | 92.7 | Stages and processes of self-change of smoking: toward an integrative model of change. | J O Prochaska, C C DiClemente | J Consult Clin Psychol | 1983 | 6863699 | Yes |
| 1092 | 4154 | 2077.0 | 100.47 | 50.2 | Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. | G G Glenner, C W Wong | Biochem Biophys Res Commun | 1984 | 6375662 | Yes |
| 1093 | 4153 | 2076.5 | 109.83 | 54.9 | The unfolded protein response: from stress pathway to homeostatic regulation. | Peter Walter, David Ron | Science | 2011 | 22116877 | No |
| 1094 | 4152 | 2076.0 | 82.05 | 41.0 | Mammalian MAP kinase signalling cascades. | L Chang, M Karin | Nature | 2001 | 11242034 | No |
| 1095 | 2076 | 2076.0 | 53.03 | 53.0 | Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. | Gökhan S Hotamisligil | Cell | 2010 | 20303879 | No |
| 1096 | 4150 | 2075.0 | 81.78 | 40.9 | Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. | M Gossen, H Bujard | Proc Natl Acad Sci U S A | 1992 | 1319065 | Yes |
| 1097 | 6223 | 2074.3 | 264.04 | 88.0 | Scoping studies: advancing the methodology. | Danielle Levac, Heather Colquhoun, Kelly K O'Brien | Implement Sci | 2010 | 20854677 | Yes |
| 1098 | 2072 | 2072.0 | 59.88 | 59.9 | ATP-regulated K+ channels in cardiac muscle. | A Noma | Nature | 1983 | 6310409 | Yes |
| 1099 | 2072 | 2072.0 | 50.85 | 50.9 | Mechanisms of hepatic fibrogenesis. | Scott L Friedman | Gastroenterology | 2008 | 18471545 | No |
| 1100 | 4143 | 2071.5 | 80.92 | 40.5 | Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. | Rudolf Jaenisch, Adrian Bird | Nat Genet | 2003 | 12610534 | No |
| 1101 | 2071 | 2071.0 | 50.53 | 50.5 | Drug-like properties and the causes of poor solubility and poor permeability. | C A Lipinski | J Pharmacol Toxicol Methods | 2000 | 11274893 | No |
| 1102 | 4142 | 2071.0 | 118.26 | 59.1 | Wnt/β-catenin signaling and disease. | Hans Clevers, Roel Nusse | Cell | 2012 | 22682243 | No |
| 1103 | 8280 | 2070.0 | 271.79 | 67.9 | Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. | A J Hughes, S E Daniel, L Kilford, A J Lees | J Neurol Neurosurg Psychiatry | 1992 | 1564476 | Yes |
| 1104 | 4139 | 2069.5 | 35.72 | 17.9 | Genetic regulatory mechanisms in the synthesis of proteins. | F Jacob, J Monod | J Mol Biol | 1961 | 13718526 | Yes |
| 1105 | 2069 | 2069.0 | 42.2 | 42.2 | The lasso method for variable selection in the Cox model. | R Tibshirani | Stat Med | 1997 | 9044528 | Yes |
| 1106 | 4132 | 2066.0 | 78.16 | 39.1 | SIFT: Predicting amino acid changes that affect protein function. | Pauline C Ng, Steven Henikoff | Nucleic Acids Res | 2003 | 12824425 | Yes |
| 1107 | 10321 | 2064.2 | 239.61 | 47.9 | Development and testing of a general amber force field. | Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A Case | J Comput Chem | 2004 | 15116359 | Yes |
| 1108 | 2064 | 2064.0 | 37.84 | 37.8 | Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. | J C Skou | Physiol Rev | 1965 | 14337569 | No |
| 1109 | 2063 | 2063.0 | 52.86 | 52.9 | The heme oxygenase system: a regulator of second messenger gases. | M D Maines | Annu Rev Pharmacol Toxicol | 1997 | 9131263 | No |
| 1110 | 2061 | 2061.0 | 41.37 | 41.4 | Metastasis to bone: causes, consequences and therapeutic opportunities. | Gregory R Mundy | Nat Rev Cancer | 2002 | 12154351 | No |
| 1111 | 4121 | 2060.5 | 85.95 | 43.0 | A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. | G Shaw, R Kamen | Cell | 1986 | 3488815 | Yes |
| 1112 | 2060 | 2060.0 | 39.74 | 39.7 | Signalling pathways of the TNF superfamily: a double-edged sword. | Bharat B Aggarwal | Nat Rev Immunol | 2003 | 12949498 | No |
| 1113 | 4116 | 2058.0 | 130.53 | 65.3 | Polymyositis and dermatomyositis (first of two parts). | A Bohan, J B Peter | N Engl J Med | 1975 | 1090839 | No |
| 1114 | 2058 | 2058.0 | 42.59 | 42.6 | G1 events and regulation of cell proliferation. | A B Pardee | Science | 1989 | 2683075 | No |
| 1115 | 6169 | 2056.3 | 202.15 | 67.4 | Parallel organization of functionally segregated circuits linking basal ganglia and cortex. | G E Alexander, M R DeLong, P L Strick | Annu Rev Neurosci | 1986 | 3085570 | No |
| 1116 | 2055 | 2055.0 | 52.28 | 52.3 | What is cognitive reserve? Theory and research application of the reserve concept. | Yaakov Stern | J Int Neuropsychol Soc | 2002 | 11939702 | No |
| 1117 | 4109 | 2054.5 | 101.25 | 50.6 | Cutaneous wound healing. | A J Singer, R A Clark | N Engl J Med | 1999 | 10471461 | No |
| 1118 | 4107 | 2053.5 | 0.0 | 0.0 | Plaque formation and isolation of pure lines with poliomyelitis viruses. | R Dulbecco, M Vogt | J Exp Med | 1954 | 13130792 | Yes |
| 1119 | 2051 | 2051.0 | 18.79 | 18.8 | The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. | W W Cleland | Biochim Biophys Acta | 1963 | 14021667 | Yes |
| 1120 | 2051 | 2051.0 | 57.24 | 57.2 | Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. | J W Littlefield | Science | 1964 | 14168277 | Yes |
| 1121 | 4100 | 2050.0 | 105.11 | 52.6 | Building better batteries. | M Armand, J-M Tarascon | Nature | 2008 | 18256660 | No |
| 1122 | 6148 | 2049.3 | 198.07 | 66.0 | Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. | C Lord, M Rutter, A Le Couteur | J Autism Dev Disord | 1994 | 7814313 | Yes |
| 1123 | 2049 | 2049.0 | 64.92 | 64.9 | Health consequences of intimate partner violence. | Jacquelyn C Campbell | Lancet | 2002 | 11965295 | No |
| 1124 | 2049 | 2049.0 | 47.87 | 47.9 | Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. | Scott L Friedman | Physiol Rev | 2008 | 18195085 | No |
| 1125 | 2048 | 2048.0 | 47.84 | 47.8 | Interleukin-2: inception, impact, and implications. | K A Smith | Science | 1988 | 3131876 | No |
| 1126 | 4096 | 2048.0 | 177.37 | 88.7 | The Brief Symptom Inventory: an introductory report. | L R Derogatis, N Melisaratos | Psychol Med | 1983 | 6622612 | Yes |
| 1127 | 2044 | 2044.0 | 60.46 | 60.5 | Global epidemiology of oral and oropharyngeal cancer. | Saman Warnakulasuriya | Oral Oncol | 2009 | 18804401 | No |
| 1128 | 4087 | 2043.5 | 110.53 | 55.3 | New perspectives in cell adhesion: RGD and integrins. | E Ruoslahti, M D Pierschbacher | Science | 1987 | 2821619 | No |
| 1129 | 2043 | 2043.0 | 41.8 | 41.8 | Molecular bases for circadian clocks. | J C Dunlap | Cell | 1999 | 9988221 | No |
| 1130 | 4083 | 2041.5 | 0.0 | 0.0 | A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. | R F Beers, I W Sizer | J Biol Chem | 1952 | 14938361 | Yes |
| 1131 | 2041 | 2041.0 | 56.48 | 56.5 | Estimating causal effects from large data sets using propensity scores. | D B Rubin | Ann Intern Med | 1997 | 9382394 | No |
| 1132 | 2034 | 2034.0 | 61.01 | 61.0 | Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? | George A Bonanno | Am Psychol | 2004 | 14736317 | No |
| 1133 | 4066 | 2033.0 | 121.37 | 60.7 | Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). | Kathryn M Connor, Jonathan R T Davidson | Depress Anxiety | 2003 | 12964174 | Yes |
| 1134 | 4063 | 2031.5 | 97.6 | 48.8 | Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. | M Nei, T Gojobori | Mol Biol Evol | 1986 | 3444411 | Yes |
| 1135 | 4060 | 2030.0 | 98.23 | 49.1 | Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. | P Liang, A B Pardee | Science | 1992 | 1354393 | Yes |
| 1136 | 2030 | 2030.0 | 39.12 | 39.1 | CpG motifs in bacterial DNA and their immune effects. | Arthur M Krieg | Annu Rev Immunol | 2002 | 11861616 | No |
| 1137 | 2027 | 2027.0 | 79.71 | 79.7 | Perception of risk. | P Slovic | Science | 1987 | 3563507 | Yes |
| 1138 | 2027 | 2027.0 | 72.09 | 72.1 | Determination of glutathione and glutathione disulfide in biological samples. | M E Anderson | Methods Enzymol | 1985 | 4088074 | Yes |
| 1139 | 2026 | 2026.0 | 47.61 | 47.6 | Calcium signaling. | D E Clapham | Cell | 1995 | 7834745 | No |
| 1140 | 4050 | 2025.0 | 79.48 | 39.7 | The Wnt signaling pathway in development and disease. | Catriona Y Logan, Roel Nusse | Annu Rev Cell Dev Biol | 2004 | 15473860 | No |
| 1141 | 2025 | 2025.0 | 128.15 | 128.2 | High-performance medicine: the convergence of human and artificial intelligence. | Eric J Topol | Nat Med | 2019 | 30617339 | No |
| 1142 | 2024 | 2024.0 | 62.2 | 62.2 | Ethical authorship and publishing. | Andrew J S Coats | Int J Cardiol | 2009 | 19046787 | No |
| 1143 | 4045 | 2022.5 | 94.58 | 47.3 | Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. | B A Reynolds, S Weiss | Science | 1992 | 1553558 | Yes |
| 1144 | 12134 | 2022.3 | 375.14 | 62.5 | Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. | Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell Parkin | Int J Cancer | 2010 | 21351269 | Yes |
| 1145 | 6066 | 2022.0 | 182.91 | 61.0 | Estimating the mean and variance from the median, range, and the size of a sample. | Stela Pudar Hozo, Benjamin Djulbegovic, Iztok Hozo | BMC Med Res Methodol | 2005 | 15840177 | Yes |
| 1146 | 8086 | 2021.5 | 303.66 | 75.9 | The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. | T F Heatherton, L T Kozlowski, R C Frecker, K O Fagerström | Br J Addict | 1991 | 1932883 | Yes |
| 1147 | 2021 | 2021.0 | 52.51 | 52.5 | Analysis of bacteriophage T7 early RNAs and proteins on slab gels. | F W Studier | J Mol Biol | 1973 | 4760132 | Yes |
| 1148 | 6061 | 2020.3 | 228.16 | 76.1 | Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. | G Muyzer, E C de Waal, A G Uitterlinden | Appl Environ Microbiol | 1993 | 7683183 | Yes |
| 1149 | 2018 | 2018.0 | 55.23 | 55.2 | Trail Making Test A and B: normative data stratified by age and education. | Tom N Tombaugh | Arch Clin Neuropsychol | 2004 | 15010086 | Yes |
| 1150 | 2017 | 2017.0 | 44.15 | 44.1 | Biology of natural killer cells. | G Trinchieri | Adv Immunol | 1989 | 2683611 | No |
| 1151 | 2017 | 2017.0 | 0.0 | 0.0 | On respiratory impairment in cancer cells. | O Warburg | Science | 1956 | 13351639 | Yes |
| 1152 | 2016 | 2016.0 | 46.86 | 46.9 | DAMPs, PAMPs and alarmins: all we need to know about danger. | Marco E Bianchi | J Leukoc Biol | 2007 | 17032697 | No |
| 1153 | 2014 | 2014.0 | 119.34 | 119.3 | Understanding Bland Altman analysis. | Davide Giavarina | Biochem Med (Zagreb) | 2015 | 26110027 | No |
| 1154 | 2013 | 2013.0 | 38.76 | 38.8 | Antiviral actions of interferons. | C E Samuel | Clin Microbiol Rev | 2001 | 11585785 | No |
| 1155 | 2011 | 2011.0 | 58.28 | 58.3 | Protein oxidation and aging. | E R Stadtman | Science | 1992 | 1355616 | No |
| 1156 | 2011 | 2011.0 | 95.97 | 96.0 | Performance-oriented assessment of mobility problems in elderly patients. | M E Tinetti | J Am Geriatr Soc | 1986 | 3944402 | Yes |
| 1157 | 2010 | 2010.0 | 0.0 | 0.0 | Antigen-antibody reactions in gels. | O Ouchterlony | Acta Pathol Microbiol Scand | 1949 | 18143039 | Yes |
| 1158 | 2009 | 2009.0 | 83.6 | 83.6 | A rating scale for drug-induced akathisia. | T R Barnes | Br J Psychiatry | 1989 | 2574607 | Yes |
| 1159 | 2009 | 2009.0 | 42.41 | 42.4 | Developmental regulation of the growth plate. | Henry M Kronenberg | Nature | 2003 | 12748651 | No |
| 1160 | 2009 | 2009.0 | 22.25 | 22.2 | Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? | J V Neel | Am J Hum Genet | 1962 | 13937884 | Yes |
| 1161 | 2008 | 2008.0 | 41.63 | 41.6 | XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. | D E McRee | J Struct Biol | 1999 | 10222271 | Yes |
| 1162 | 2006 | 2006.0 | 51.07 | 51.1 | Flow-mediated endothelial mechanotransduction. | P F Davies | Physiol Rev | 1995 | 7624393 | No |
| 1163 | 2005 | 2005.0 | 48.3 | 48.3 | Python: a programming language for software integration and development. | M F Sanner | J Mol Graph Model | 1999 | 10660911 | Yes |
| 1164 | 2005 | 2005.0 | 34.65 | 34.6 | ATM and related protein kinases: safeguarding genome integrity. | Yosef Shiloh | Nat Rev Cancer | 2003 | 12612651 | No |
| 1165 | 8018 | 2004.5 | 327.59 | 81.9 | jModelTest 2: more models, new heuristics and parallel computing. | Diego Darriba, Guillermo L Taboada, Ramón Doallo, David Posada | Nat Methods | 2012 | 22847109 | Yes |
| 1166 | 4007 | 2003.5 | 119.14 | 59.6 | Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. | James J Gross, Oliver P John | J Pers Soc Psychol | 2003 | 12916575 | Yes |
| 1167 | 2003 | 2003.0 | 68.52 | 68.5 | The emerging role of lncRNAs in cancer. | Maite Huarte | Nat Med | 2015 | 26540387 | No |
| 1168 | 2002 | 2002.0 | 50.17 | 50.2 | Determination and analysis of urea and guanidine hydrochloride denaturation curves. | C N Pace | Methods Enzymol | 1986 | 3773761 | Yes |
| 1169 | 2001 | 2001.0 | 36.66 | 36.7 | In situ hybridization: an improved whole-mount method for Xenopus embryos. | R M Harland | Methods Cell Biol | 1991 | 1811161 | Yes |
| 1170 | 8003 | 2000.8 | 236.19 | 59.0 | Antibiotic susceptibility testing by a standardized single disk method. | A W Bauer, W M Kirby, J C Sherris, M Turck | Am J Clin Pathol | 1966 | 5325707 | Yes |
| 1171 | 2000 | 2000.0 | 39.53 | 39.5 | DNA topoisomerases: structure, function, and mechanism. | J J Champoux | Annu Rev Biochem | 2001 | 11395412 | No |
| 1172 | 2000 | 2000.0 | 54.96 | 55.0 | Determination of minimum inhibitory concentrations. | J M Andrews | J Antimicrob Chemother | 2001 | 11420333 | Yes |
| 1173 | 21993 | 1999.4 | 546.45 | 49.7 | PLINK: a tool set for whole-genome association and population-based linkage analyses. | Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C Sham | Am J Hum Genet | 2007 | 17701901 | Yes |
| 1174 | 1999 | 1999.0 | 43.76 | 43.8 | Structural design and molecular evolution of a cytokine receptor superfamily. | J F Bazan | Proc Natl Acad Sci U S A | 1990 | 2169613 | Yes |
| 1175 | 1999 | 1999.0 | 55.95 | 56.0 | Flavonoids as antioxidants. | P G Pietta | J Nat Prod | 2000 | 10924197 | No |
| 1176 | 3998 | 1999.0 | 135.01 | 67.5 | PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. | Daniel R Roe, Thomas E Cheatham | J Chem Theory Comput | 2013 | 26583988 | Yes |
| 1177 | 7990 | 1997.5 | 194.09 | 48.5 | Cancer-related inflammation. | Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill | Nature | 2008 | 18650914 | No |
| 1178 | 1997 | 1997.0 | 43.51 | 43.5 | Neutrophils and immunity: challenges and opportunities. | Carl Nathan | Nat Rev Immunol | 2006 | 16498448 | No |
| 1179 | 3991 | 1995.5 | 88.17 | 44.1 | The DNA-damage response in human biology and disease. | Stephen P Jackson, Jiri Bartek | Nature | 2009 | 19847258 | No |
| 1180 | 13960 | 1994.3 | 307.08 | 43.9 | Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. | Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman | Genome Biol | 2002 | 12184808 | Yes |
| 1181 | 3987 | 1993.5 | 91.26 | 45.6 | Base-calling of automated sequencer traces using phred. II. Error probabilities. | B Ewing, P Green | Genome Res | 1998 | 9521922 | Yes |
| 1182 | 3985 | 1992.5 | 117.25 | 58.6 | Mechanisms of salinity tolerance. | Rana Munns, Mark Tester | Annu Rev Plant Biol | 2008 | 18444910 | No |
| 1183 | 1991 | 1991.0 | 38.7 | 38.7 | Approaching the asymptote? Evolution and revolution in immunology. | C A Janeway | Cold Spring Harb Symp Quant Biol | 1989 | 2700931 | No |
| 1184 | 1991 | 1991.0 | 42.49 | 42.5 | The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. | U E Loening | Biochem J | 1967 | 5339944 | Yes |
| 1185 | 3982 | 1991.0 | 87.77 | 43.9 | Issues and challenges facing rechargeable lithium batteries. | J M Tarascon, M Armand | Nature | 2001 | 11713543 | Yes |
| 1186 | 1991 | 1991.0 | 41.5 | 41.5 | TRP channels as cellular sensors. | David E Clapham | Nature | 2003 | 14654832 | No |
| 1187 | 1991 | 1991.0 | 62.34 | 62.3 | Receiver operating characteristic curve in diagnostic test assessment. | Jayawant N Mandrekar | J Thorac Oncol | 2010 | 20736804 | No |
| 1188 | 3980 | 1990.0 | 89.82 | 44.9 | The acute respiratory distress syndrome. | L B Ware, M A Matthay | N Engl J Med | 2000 | 10793167 | No |
| 1189 | 3978 | 1989.0 | 85.47 | 42.7 | Lessons from hereditary colorectal cancer. | K W Kinzler, B Vogelstein | Cell | 1996 | 8861899 | No |
| 1190 | 1989 | 1989.0 | 43.57 | 43.6 | Gene finding in novel genomes. | Ian Korf | BMC Bioinformatics | 2004 | 15144565 | Yes |
| 1191 | 1988 | 1988.0 | 54.79 | 54.8 | The biology of interleukin-6. | T Kishimoto | Blood | 1989 | 2473791 | No |
| 1192 | 1988 | 1988.0 | 47.72 | 47.7 | Interfaces and the driving force of hydrophobic assembly. | David Chandler | Nature | 2005 | 16193038 | No |
| 1193 | 3974 | 1987.0 | 86.24 | 43.1 | The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. | A J Ridley, A Hall | Cell | 1992 | 1643657 | Yes |
| 1194 | 1987 | 1987.0 | 39.16 | 39.2 | DNA methylation and human disease. | Keith D Robertson | Nat Rev Genet | 2005 | 16136652 | No |
| 1195 | 5959 | 1986.3 | 160.56 | 53.5 | trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. | Salvador Capella-Gutiérrez, José M Silla-Martínez, Toni Gabaldón | Bioinformatics | 2009 | 19505945 | Yes |
| 1196 | 1985 | 1985.0 | 40.66 | 40.7 | Mechanisms of intracellular protein transport. | J E Rothman | Nature | 1994 | 7969419 | No |
| 1197 | 1985 | 1985.0 | 48.54 | 48.5 | Negative refraction makes a perfect lens | J B Pendry | Phys Rev Lett | 2000 | 11041972 | Yes |
| 1198 | 3970 | 1985.0 | 89.98 | 45.0 | Liver fibrosis. | Ramón Bataller, David A Brenner | J Clin Invest | 2005 | 15690074 | No |
| 1199 | 1984 | 1984.0 | 65.91 | 65.9 | The use of a plus-maze to measure anxiety in the mouse. | R G Lister | Psychopharmacology (Berl) | 1987 | 3110839 | Yes |
| 1200 | 1980 | 1980.0 | 61.53 | 61.5 | A new automated colorimetric method for measuring total oxidant status. | Ozcan Erel | Clin Biochem | 2005 | 16214125 | Yes |
| 1201 | 13851 | 1978.7 | 315.74 | 45.1 | Induction of pluripotent stem cells from adult human fibroblasts by defined factors. | Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka | Cell | 2007 | 18035408 | Yes |
| 1202 | 3955 | 1977.5 | 109.92 | 55.0 | Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. | B J Marshall, J R Warren | Lancet | 1984 | 6145023 | Yes |
| 1203 | 1977 | 1977.0 | 62.91 | 62.9 | Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. | Sergio Pecorelli | Int J Gynaecol Obstet | 2009 | 19367689 | No |
| 1204 | 3951 | 1975.5 | 98.04 | 49.0 | Leptin and the regulation of body weight in mammals. | J M Friedman, J L Halaas | Nature | 1998 | 9796811 | No |
| 1205 | 1975 | 1975.0 | 69.99 | 70.0 | Pro-resolving lipid mediators are leads for resolution physiology. | Charles N Serhan | Nature | 2014 | 24899309 | No |
| 1206 | 3949 | 1974.5 | 141.04 | 70.5 | ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. | M Gardes, T D Bruns | Mol Ecol | 1993 | 8180733 | Yes |
| 1207 | 3949 | 1974.5 | 136.81 | 68.4 | Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. | Sarvajeet Singh Gill, Narendra Tuteja | Plant Physiol Biochem | 2010 | 20870416 | No |
| 1208 | 1973 | 1973.0 | 49.3 | 49.3 | Hydrogels for biomedical applications. | Allan S Hoffman | Adv Drug Deliv Rev | 2002 | 11755703 | No |
| 1209 | 1972 | 1972.0 | 100.9 | 100.9 | Subjective well-being. | E Diener | Psychol Bull | 1984 | 6399758 | No |
| 1210 | 3943 | 1971.5 | 108.27 | 54.1 | Insulin-like growth factors and their binding proteins: biological actions. | J I Jones, D R Clemmons | Endocr Rev | 1995 | 7758431 | No |
| 1211 | 1970 | 1970.0 | 52.64 | 52.6 | Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. | J Folkman | N Engl J Med | 1995 | 7491141 | No |
| 1212 | 1969 | 1969.0 | 48.17 | 48.2 | Pathogen recognition and inflammatory signaling in innate immune defenses. | Trine H Mogensen | Clin Microbiol Rev | 2009 | 19366914 | No |
| 1213 | 5905 | 1968.3 | 192.01 | 64.0 | AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. | P G Reeves, F H Nielsen, G C Fahey | J Nutr | 1993 | 8229312 | No |
| 1214 | 1967 | 1967.0 | 89.05 | 89.0 | A modified card sorting test sensitive to frontal lobe defects. | H E Nelson | Cortex | 1976 | 1009768 | Yes |
| 1215 | 1966 | 1966.0 | 61.63 | 61.6 | Epidemiological features of chronic low-back pain. | G B Andersson | Lancet | 1999 | 10470716 | No |
| 1216 | 1965 | 1965.0 | 62.3 | 62.3 | Calculation of substrate oxidation rates in vivo from gaseous exchange. | K N Frayn | J Appl Physiol Respir Environ Exerc Physiol | 1983 | 6618956 | Yes |
| 1217 | 1964 | 1964.0 | 34.79 | 34.8 | Signaling--2000 and beyond. | T Hunter | Cell | 2000 | 10647936 | No |
| 1218 | 1963 | 1963.0 | 115.33 | 115.3 | Making sense of implementation theories, models and frameworks. | Per Nilsen | Implement Sci | 2015 | 25895742 | Yes |
| 1219 | 1962 | 1962.0 | 0.0 | 0.0 | Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. | M Kunitz | J Gen Physiol | 1947 | 19873496 | Yes |
| 1220 | 3922 | 1961.0 | 96.49 | 48.2 | Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. | P J Barnes, M Karin | N Engl J Med | 1997 | 9091804 | No |
| 1221 | 1960 | 1960.0 | 57.71 | 57.7 | Intracellular calcium homeostasis. | E Carafoli | Annu Rev Biochem | 1987 | 3304139 | No |
| 1222 | 3917 | 1958.5 | 125.71 | 62.9 | Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. | A C Chang, S N Cohen | J Bacteriol | 1978 | 149110 | Yes |
| 1223 | 1958 | 1958.0 | 41.09 | 41.1 | The immunopathogenesis of sepsis. | Jonathan Cohen | Nature | 2002 | 12490963 | No |
| 1224 | 1958 | 1958.0 | 60.09 | 60.1 | Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. | Berislav V Zlokovic | Nat Rev Neurosci | 2011 | 22048062 | No |
| 1225 | 1957 | 1957.0 | 45.81 | 45.8 | The global health burden of infection-associated cancers in the year 2002. | Donald Maxwell Parkin | Int J Cancer | 2006 | 16404738 | Yes |
| 1226 | 1957 | 1957.0 | 37.32 | 37.3 | Notch signalling: a simple pathway becomes complex. | Sarah J Bray | Nat Rev Mol Cell Biol | 2006 | 16921404 | No |
| 1227 | 1956 | 1956.0 | 45.08 | 45.1 | Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. | B L Wajchenberg | Endocr Rev | 2000 | 11133069 | No |
| 1228 | 1955 | 1955.0 | 62.41 | 62.4 | Grounded cognition. | Lawrence W Barsalou | Annu Rev Psychol | 2008 | 17705682 | No |
| 1229 | 1953 | 1953.0 | 34.14 | 34.1 | Mechanisms of alternative pre-messenger RNA splicing. | Douglas L Black | Annu Rev Biochem | 2003 | 12626338 | No |
| 1230 | 1952 | 1952.0 | 0.0 | 0.0 | Dendritic organization in the neurons of the visual and motor cortices of the cat. | D A Sholl | J Anat | 1953 | 13117757 | Yes |
| 1231 | 1952 | 1952.0 | 0.0 | 0.0 | Influences of glucose loading and of injected insulin on hepatic glucose output. | R Steele | Ann N Y Acad Sci | 1959 | 13833973 | Yes |
| 1232 | 3902 | 1951.0 | 130.99 | 65.5 | Mathematical model for studying genetic variation in terms of restriction endonucleases. | M Nei, W H Li | Proc Natl Acad Sci U S A | 1979 | 291943 | Yes |
| 1233 | 3900 | 1950.0 | 140.92 | 70.5 | Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. | W R Morrison, L M Smith | J Lipid Res | 1964 | 14221106 | Yes |
| 1234 | 1949 | 1949.0 | 61.18 | 61.2 | Sick individuals and sick populations. | G Rose | Int J Epidemiol | 1985 | 3872850 | Yes |
| 1235 | 5844 | 1948.0 | 107.06 | 35.7 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. | Jason D Fontenot, Marc A Gavin, Alexander Y Rudensky | Nat Immunol | 2003 | 12612578 | Yes |
| 1236 | 3894 | 1947.0 | 94.82 | 47.4 | Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. | J G Rheinwald, H Green | Cell | 1975 | 1052771 | Yes |
| 1237 | 1947 | 1947.0 | 39.36 | 39.4 | The expanding role of mitochondria in apoptosis. | X Wang | Genes Dev | 2001 | 11711427 | No |
| 1238 | 1946 | 1946.0 | 79.64 | 79.6 | Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. | A Fleckenstein | Annu Rev Pharmacol Toxicol | 1977 | 326161 | No |
| 1239 | 3892 | 1946.0 | 65.22 | 32.6 | Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. | I W McLean, P K Nakane | J Histochem Cytochem | 1974 | 4374474 | Yes |
| 1240 | 1946 | 1946.0 | 0.0 | 0.0 | On estimating the relation between blood group and disease. | B Woolf | Ann Hum Genet | 1955 | 14388528 | Yes |
| 1241 | 1945 | 1945.0 | 37.53 | 37.5 | Systems biology: a brief overview. | Hiroaki Kitano | Science | 2002 | 11872829 | No |
| 1242 | 1945 | 1945.0 | 38.92 | 38.9 | The complex language of chromatin regulation during transcription. | Shelley L Berger | Nature | 2007 | 17522673 | No |
| 1243 | 1944 | 1944.0 | 39.78 | 39.8 | Thrombin signalling and protease-activated receptors. | S R Coughlin | Nature | 2000 | 11001069 | No |
| 1244 | 5829 | 1943.0 | 120.0 | 40.0 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel, J D Roberts, R A Zakour | Methods Enzymol | 1987 | 3323813 | Yes |
| 1245 | 1940 | 1940.0 | 0.0 | 0.0 | The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. | S V Boyden | J Exp Med | 1951 | 14803635 | Yes |
| 1246 | 1939 | 1939.0 | 41.15 | 41.1 | Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. | A Breslow | Ann Surg | 1970 | 5477666 | Yes |
| 1247 | 1938 | 1938.0 | 64.45 | 64.5 | Intermediate filaments as mechanical integrators of cellular space. | E Lazarides | Nature | 1980 | 7188712 | Yes |
| 1248 | 3875 | 1937.5 | 121.73 | 60.9 | Understanding interobserver agreement: the kappa statistic. | Anthony J Viera, Joanne M Garrett | Fam Med | 2005 | 15883903 | Yes |
| 1249 | 1937 | 1937.0 | 49.98 | 50.0 | Dengue and dengue hemorrhagic fever. | D J Gubler | Clin Microbiol Rev | 1998 | 9665979 | No |
| 1250 | 5804 | 1934.7 | 168.81 | 56.3 | Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. | Helga Thorvaldsdóttir, James T Robinson, Jill P Mesirov | Brief Bioinform | 2013 | 22517427 | Yes |
| 1251 | 1934 | 1934.0 | 60.12 | 60.1 | Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. | J P Chamberlain | Anal Biochem | 1979 | 543547 | Yes |
| 1252 | 3868 | 1934.0 | 122.79 | 61.4 | Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. | R L Heath, L Packer | Arch Biochem Biophys | 1968 | 5655425 | Yes |
| 1253 | 3868 | 1934.0 | 90.41 | 45.2 | Neuronal oscillations in cortical networks. | György Buzsáki, Andreas Draguhn | Science | 2004 | 15218136 | No |
| 1254 | 1931 | 1931.0 | 57.61 | 57.6 | Calbindin D-28k and parvalbumin in the rat nervous system. | M R Celio | Neuroscience | 1990 | 2199841 | Yes |
| 1255 | 1931 | 1931.0 | 23.2 | 23.2 | A theory of cerebellar cortex. | D Marr | J Physiol | 1969 | 5784296 | Yes |
| 1256 | 1929 | 1929.0 | 55.12 | 55.1 | Excitotoxic cell death. | D W Choi | J Neurobiol | 1992 | 1361523 | No |
| 1257 | 1929 | 1929.0 | 46.73 | 46.7 | Episodic memory: from mind to brain. | Endel Tulving | Annu Rev Psychol | 2002 | 11752477 | Yes |
| 1258 | 1928 | 1928.0 | 50.66 | 50.7 | DNA topoisomerase poisons as antitumor drugs. | L F Liu | Annu Rev Biochem | 1989 | 2549853 | No |
| 1259 | 1927 | 1927.0 | 42.7 | 42.7 | Signal sequences. The limits of variation. | G von Heijne | J Mol Biol | 1985 | 4032478 | Yes |
| 1260 | 3852 | 1926.0 | 94.55 | 47.3 | The endophenotype concept in psychiatry: etymology and strategic intentions. | Irving I Gottesman, Todd D Gould | Am J Psychiatry | 2003 | 12668349 | No |
| 1261 | 1926 | 1926.0 | 42.16 | 42.2 | The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. | Michael R Lieber | Annu Rev Biochem | 2010 | 20192759 | No |
| 1262 | 3850 | 1925.0 | 102.68 | 51.3 | Inositol phosphates and cell signalling. | M J Berridge, R F Irvine | Nature | 1989 | 2550825 | No |
| 1263 | 1925 | 1925.0 | 43.06 | 43.1 | High-speed scanning in human memory. | S Sternberg | Science | 1966 | 5939936 | Yes |
| 1264 | 3849 | 1924.5 | 122.2 | 61.1 | Oxygen toxicity, oxygen radicals, transition metals and disease. | B Halliwell, J M Gutteridge | Biochem J | 1984 | 6326753 | No |
| 1265 | 1924 | 1924.0 | 44.45 | 44.5 | The retinal pigment epithelium in visual function. | Olaf Strauss | Physiol Rev | 2005 | 15987797 | No |
| 1266 | 1923 | 1923.0 | 41.68 | 41.7 | A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. | J SantaLucia | Proc Natl Acad Sci U S A | 1998 | 9465037 | Yes |
| 1267 | 3846 | 1923.0 | 73.53 | 36.8 | Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. | M Karin, Y Ben-Neriah | Annu Rev Immunol | 2000 | 10837071 | No |
| 1268 | 5768 | 1922.7 | 190.1 | 63.4 | Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. | L Excoffier, P E Smouse, J M Quattro | Genetics | 1992 | 1644282 | Yes |
| 1269 | 1922 | 1922.0 | 83.64 | 83.6 | Brain dopamine receptors. | P Seeman | Pharmacol Rev | 1980 | 6117090 | No |
| 1270 | 3839 | 1919.5 | 130.45 | 65.2 | Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. | M H Zweig, G Campbell | Clin Chem | 1993 | 8472349 | No |
| 1271 | 7676 | 1919.0 | 185.47 | 46.4 | Improved optimization for the robust and accurate linear registration and motion correction of brain images. | Mark Jenkinson, Peter Bannister, Michael Brady, Stephen Smith | Neuroimage | 2002 | 12377157 | Yes |
| 1272 | 1919 | 1919.0 | 39.97 | 40.0 | Maintenance of C. elegans. | Theresa Stiernagle | WormBook | 2006 | 18050451 | No |
| 1273 | 1919 | 1919.0 | 58.52 | 58.5 | Matching methods for causal inference: A review and a look forward. | Elizabeth A Stuart | Stat Sci | 2010 | 20871802 | Yes |
| 1274 | 1918 | 1918.0 | 56.38 | 56.4 | Inhibited spontaneous emission in solid-state physics and electronics. | E Yablonovitch | Phys Rev Lett | 1987 | 10034639 | Yes |
| 1275 | 1918 | 1918.0 | 45.48 | 45.5 | The genetics of ageing. | Cynthia J Kenyon | Nature | 2010 | 20336132 | No |
| 1276 | 1917 | 1917.0 | 63.09 | 63.1 | Physiological actions of taurine. | R J Huxtable | Physiol Rev | 1992 | 1731369 | No |
| 1277 | 1917 | 1917.0 | 33.81 | 33.8 | The regulation of E2F by pRB-family proteins. | N Dyson | Genes Dev | 1998 | 9694791 | No |
| 1278 | 1917 | 1917.0 | 39.09 | 39.1 | Mechanisms of cancer drug resistance. | Michael M Gottesman | Annu Rev Med | 2002 | 11818492 | No |
| 1279 | 1916 | 1916.0 | 59.8 | 59.8 | The Gingival Index, the Plaque Index and the Retention Index Systems. | H Löe | J Periodontol | 1967 | 5237684 | Yes |
| 1280 | 3831 | 1915.5 | 98.63 | 49.3 | Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering | S Nie, S R Emory | Science | 1997 | 9027306 | Yes |
| 1281 | 3831 | 1915.5 | 0.0 | 0.0 | Acetylornithinase of Escherichia coli: partial purification and some properties. | H J Vogel, D M Bonner | J Biol Chem | 1956 | 13278318 | Yes |
| 1282 | 1915 | 1915.0 | 40.03 | 40.0 | A cell culture model for T lymphocyte clonal anergy. | R H Schwartz | Science | 1990 | 2113314 | Yes |
| 1283 | 1915 | 1915.0 | 46.98 | 47.0 | DNA topoisomerases. | J C Wang | Annu Rev Biochem | 1985 | 2992360 | No |
| 1284 | 1914 | 1914.0 | 53.22 | 53.2 | Cell biology and molecular basis of denitrification. | W G Zumft | Microbiol Mol Biol Rev | 1997 | 9409151 | No |
| 1285 | 1914 | 1914.0 | 46.24 | 46.2 | Cancer chemoprevention with dietary phytochemicals. | Young-Joon Surh | Nat Rev Cancer | 2003 | 14570043 | No |
| 1286 | 7654 | 1913.5 | 297.99 | 74.5 | A simple technique for quantitation of low levels of DNA damage in individual cells. | N P Singh, M T McCoy, R R Tice, E L Schneider | Exp Cell Res | 1988 | 3345800 | Yes |
| 1287 | 7651 | 1912.8 | 188.55 | 47.1 | p53 mutations in human cancers. | M Hollstein, D Sidransky, B Vogelstein, C C Harris | Science | 1991 | 1905840 | No |
| 1288 | 1910 | 1910.0 | 54.8 | 54.8 | The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. | G P Chrousos | N Engl J Med | 1995 | 7715646 | No |
| 1289 | 3820 | 1910.0 | 84.82 | 42.4 | Parkinson's disease: mechanisms and models. | William Dauer, Serge Przedborski | Neuron | 2003 | 12971891 | No |
| 1290 | 1909 | 1909.0 | 46.19 | 46.2 | Thioredoxin. | A Holmgren | Annu Rev Biochem | 1985 | 3896121 | No |
| 1291 | 1909 | 1909.0 | 44.94 | 44.9 | The dawning era of polymer therapeutics. | Ruth Duncan | Nat Rev Drug Discov | 2003 | 12750738 | No |
| 1292 | 1908 | 1908.0 | 43.09 | 43.1 | Targeting PI3K signalling in cancer: opportunities, challenges and limitations. | Jeffrey A Engelman | Nat Rev Cancer | 2009 | 19629070 | No |
| 1293 | 1907 | 1907.0 | 51.46 | 51.5 | Systemic lupus erythematosus. | George C Tsokos | N Engl J Med | 2011 | 22129255 | No |
| 1294 | 7627 | 1906.8 | 185.73 | 46.4 | Epithelial-mesenchymal transitions in development and disease. | Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela Nieto | Cell | 2009 | 19945376 | No |
| 1295 | 1903 | 1903.0 | 54.11 | 54.1 | In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. | T R Chen | Exp Cell Res | 1977 | 65285 | Yes |
| 1296 | 3806 | 1903.0 | 114.99 | 57.5 | Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. | Stephen M Smith, Thomas E Nichols | Neuroimage | 2009 | 18501637 | Yes |
| 1297 | 1901 | 1901.0 | 63.07 | 63.1 | The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. | G S Manning | Q Rev Biophys | 1978 | 353876 | No |
| 1298 | 1901 | 1901.0 | 40.47 | 40.5 | The etiology of chondromalacia patellae. | R E Outerbridge | J Bone Joint Surg Br | 1961 | 14038135 | Yes |
| 1299 | 3801 | 1900.5 | 129.87 | 64.9 | Regulation of microRNA biogenesis. | Minju Ha, V Narry Kim | Nat Rev Mol Cell Biol | 2014 | 25027649 | No |
| 1300 | 1900 | 1900.0 | 0.0 | 0.0 | The oxidation of ribonuclease with performic acid. | C H Hirs | J Biol Chem | 1956 | 13319283 | Yes |
| 1301 | 1899 | 1899.0 | 74.09 | 74.1 | Predicting basal metabolic rate, new standards and review of previous work. | W N Schofield | Hum Nutr Clin Nutr | 1985 | 4044297 | Yes |
| 1302 | 15191 | 1898.9 | 630.15 | 78.8 | The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. | Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jörg Peplies, Frank Oliver Glöckner | Nucleic Acids Res | 2013 | 23193283 | Yes |
| 1303 | 1898 | 1898.0 | 53.29 | 53.3 | Introduction and General Overview of Cyclodextrin Chemistry. | József Szejtli | Chem Rev | 1998 | 11848947 | Yes |
| 1304 | 5691 | 1897.0 | 144.98 | 48.3 | Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. | G S Hotamisligil, N S Shargill, B M Spiegelman | Science | 1993 | 7678183 | Yes |
| 1305 | 1896 | 1896.0 | 53.4 | 53.4 | Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. | A Dunaif | Endocr Rev | 1997 | 9408743 | No |
| 1306 | 1896 | 1896.0 | 69.54 | 69.5 | Cognitive reserve in ageing and Alzheimer's disease. | Yaakov Stern | Lancet Neurol | 2012 | 23079557 | No |
| 1307 | 5685 | 1895.0 | 341.83 | 113.9 | Research diagnostic criteria: rationale and reliability. | R L Spitzer, J Endicott, E Robins | Arch Gen Psychiatry | 1978 | 655775 | Yes |
| 1308 | 1895 | 1895.0 | 65.26 | 65.3 | Guided Search 2.0 A revised model of visual search. | J M Wolfe | Psychon Bull Rev | 1994 | 24203471 | Yes |
| 1309 | 5685 | 1895.0 | 197.21 | 65.7 | Molecular mechanisms of epithelial-mesenchymal transition. | Samy Lamouille, Jian Xu, Rik Derynck | Nat Rev Mol Cell Biol | 2014 | 24556840 | No |
| 1310 | 3787 | 1893.5 | 156.64 | 78.3 | Cancer immunotherapy using checkpoint blockade. | Antoni Ribas, Jedd D Wolchok | Science | 2018 | 29567705 | No |
| 1311 | 1893 | 1893.0 | 41.15 | 41.1 | The mitogen-activated protein kinase signal transduction pathway. | R J Davis | J Biol Chem | 1993 | 8325833 | No |
| 1312 | 3783 | 1891.5 | 118.12 | 59.1 | Efficient pseudopotentials for plane-wave calculations. | N Troullier, J L Martins | Phys Rev B Condens Matter | 1991 | 9997467 | Yes |
| 1313 | 5671 | 1890.3 | 437.13 | 145.7 | An interactive web-based dashboard to track COVID-19 in real time. | Ensheng Dong, Hongru Du, Lauren Gardner | Lancet Infect Dis | 2020 | 32087114 | Yes |
| 1314 | 3780 | 1890.0 | 84.93 | 42.5 | Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. | T Miyashita, J C Reed | Cell | 1995 | 7834749 | Yes |
| 1315 | 15118 | 1889.8 | 368.78 | 46.1 | Electric field effect in atomically thin carbon films. | K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A Firsov | Science | 2004 | 15499015 | Yes |
| 1316 | 3779 | 1889.5 | 107.34 | 53.7 | Event-related EEG/MEG synchronization and desynchronization: basic principles. | G Pfurtscheller, F H Lopes da Silva | Clin Neurophysiol | 1999 | 10576479 | No |
| 1317 | 1887 | 1887.0 | 59.77 | 59.8 | Complete nucleotide sequence of the Escherichia coli plasmid pBR322. | J G Sutcliffe | Cold Spring Harb Symp Quant Biol | 1979 | 383387 | Yes |
| 1318 | 1887 | 1887.0 | 69.14 | 69.1 | Recognition-by-components: a theory of human image understanding. | Irving Biederman | Psychol Rev | 1987 | 3575582 | Yes |
| 1319 | 1887 | 1887.0 | 49.96 | 50.0 | Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. | Robert E Marx | J Oral Maxillofac Surg | 2003 | 12966493 | Yes |
| 1320 | 3772 | 1886.0 | 104.24 | 52.1 | EQ-5D: a measure of health status from the EuroQol Group. | R Rabin, F de Charro | Ann Med | 2001 | 11491192 | No |
| 1321 | 3771 | 1885.5 | 135.69 | 67.8 | Pain assessment: global use of the Brief Pain Inventory. | C S Cleeland, K M Ryan | Ann Acad Med Singap | 1994 | 8080219 | No |
| 1322 | 3768 | 1884.0 | 115.39 | 57.7 | An efficient mRNA-dependent translation system from reticulocyte lysates. | H R Pelham, R J Jackson | Eur J Biochem | 1976 | 823012 | Yes |
| 1323 | 1883 | 1883.0 | 16.0 | 16.0 | Positional information and the spatial pattern of cellular differentiation. | L Wolpert | J Theor Biol | 1969 | 4390734 | Yes |
| 1324 | 1883 | 1883.0 | 45.37 | 45.4 | The hydrogen bond in the solid state. | Thomas Steiner | Angew Chem Int Ed Engl | 2002 | 12491444 | Yes |
| 1325 | 3765 | 1882.5 | 152.57 | 76.3 | mTOR Signaling in Growth, Metabolism, and Disease. | Robert A Saxton, David M Sabatini | Cell | 2017 | 28283069 | No |
| 1326 | 1882 | 1882.0 | 68.87 | 68.9 | Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. | D R Janero | Free Radic Biol Med | 1990 | 2079232 | No |
| 1327 | 1882 | 1882.0 | 48.22 | 48.2 | From sensation to cognition. | M M Mesulam | Brain | 1998 | 9648540 | No |
| 1328 | 7527 | 1881.8 | 252.63 | 63.2 | Reporting results of cancer treatment. | A B Miller, B Hoogstraten, M Staquet, A Winkler | Cancer | 1981 | 7459811 | Yes |
| 1329 | 3763 | 1881.5 | 68.31 | 34.2 | Rho GTPases in cell biology. | Sandrine Etienne-Manneville, Alan Hall | Nature | 2002 | 12478284 | No |
| 1330 | 1881 | 1881.0 | 78.97 | 79.0 | The drug abuse screening test. | H A Skinner | Addict Behav | 1982 | 7183189 | Yes |
| 1331 | 3762 | 1881.0 | 136.78 | 68.4 | The need to belong: desire for interpersonal attachments as a fundamental human motivation. | R F Baumeister, M R Leary | Psychol Bull | 1995 | 7777651 | No |
| 1332 | 3762 | 1881.0 | 89.65 | 44.8 | The future of genetic studies of complex human diseases. | N Risch, K Merikangas | Science | 1996 | 8801636 | Yes |
| 1333 | 3762 | 1881.0 | 334.97 | 167.5 | WHO Declares COVID-19 a Pandemic. | Domenico Cucinotta, Maurizio Vanelli | Acta Biomed | 2020 | 32191675 | Yes |
| 1334 | 1880 | 1880.0 | 41.12 | 41.1 | Cellular mechanisms of insulin resistance. | G I Shulman | J Clin Invest | 2000 | 10903330 | No |
| 1335 | 3757 | 1878.5 | 86.1 | 43.0 | The Fas death factor. | S Nagata, P Golstein | Science | 1995 | 7533326 | No |
| 1336 | 1875 | 1875.0 | 53.57 | 53.6 | Multiple imputation: a primer. | J L Schafer | Stat Methods Med Res | 1999 | 10347857 | No |
| 1337 | 9366 | 1873.2 | 221.67 | 44.3 | Mapping and quantifying mammalian transcriptomes by RNA-Seq. | Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara Wold | Nat Methods | 2008 | 18516045 | Yes |
| 1338 | 3745 | 1872.5 | 86.1 | 43.0 | PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. | Alexander W Schüttelkopf, Daan M F van Aalten | Acta Crystallogr D Biol Crystallogr | 2004 | 15272157 | Yes |
| 1339 | 1870 | 1870.0 | 89.01 | 89.0 | A simple fluorometric assay for lipoperoxide in blood plasma. | K Yagi | Biochem Med | 1976 | 962904 | Yes |
| 1340 | 3739 | 1869.5 | 78.45 | 39.2 | Monocyte and macrophage heterogeneity. | Siamon Gordon, Philip R Taylor | Nat Rev Immunol | 2005 | 16322748 | No |
| 1341 | 1869 | 1869.0 | 39.94 | 39.9 | Exploring complex networks. | S H Strogatz | Nature | 2001 | 11258382 | No |
| 1342 | 3737 | 1868.5 | 125.52 | 62.8 | Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. | G Di Chiara, A Imperato | Proc Natl Acad Sci U S A | 1988 | 2899326 | Yes |
| 1343 | 1867 | 1867.0 | 50.79 | 50.8 | A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. | P J Goodford | J Med Chem | 1985 | 3892003 | Yes |
| 1344 | 1867 | 1867.0 | 60.15 | 60.1 | Cognitive reserve. | Yaakov Stern | Neuropsychologia | 2009 | 19467352 | No |
| 1345 | 1866 | 1866.0 | 48.95 | 49.0 | Molecular dissection of reactive astrogliosis and glial scar formation. | Michael V Sofroniew | Trends Neurosci | 2009 | 19782411 | No |
| 1346 | 13056 | 1865.1 | 464.38 | 66.3 | Assessing the quality of reports of randomized clinical trials: is blinding necessary? | A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuay | Control Clin Trials | 1996 | 8721797 | Yes |
| 1347 | 1865 | 1865.0 | 43.95 | 44.0 | The mitochondrial permeability transition pore and its role in cell death. | M Crompton | Biochem J | 1999 | 10393078 | No |
| 1348 | 1864 | 1864.0 | 37.4 | 37.4 | Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. | R J Kaufman | Genes Dev | 1999 | 10346810 | No |
| 1349 | 5592 | 1864.0 | 125.24 | 41.7 | A new statistical method for haplotype reconstruction from population data. | M Stephens, N J Smith, P Donnelly | Am J Hum Genet | 2001 | 11254454 | Yes |
| 1350 | 1864 | 1864.0 | 41.88 | 41.9 | Integrating cell-signalling pathways with NF-kappaB and IKK function. | Neil D Perkins | Nat Rev Mol Cell Biol | 2007 | 17183360 | No |
| 1351 | 1864 | 1864.0 | 44.42 | 44.4 | Integration, scaling, space-group assignment and post-refinement. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124693 | Yes |
| 1352 | 3727 | 1863.5 | 77.14 | 38.6 | Identification of common molecular subsequences. | T F Smith, M S Waterman | J Mol Biol | 1981 | 7265238 | Yes |
| 1353 | 3720 | 1860.0 | 78.72 | 39.4 | Raster3D: photorealistic molecular graphics. | E A Merritt, D J Bacon | Methods Enzymol | 1997 | 18488322 | Yes |
| 1354 | 1860 | 1860.0 | 114.6 | 114.6 | The Global Epidemic of the Metabolic Syndrome. | Mohammad G Saklayen | Curr Hypertens Rep | 2018 | 29480368 | No |
| 1355 | 1859 | 1859.0 | 48.7 | 48.7 | Hepatitis B virus infection. | W M Lee | N Engl J Med | 1997 | 9392700 | No |
| 1356 | 1858 | 1858.0 | 52.09 | 52.1 | Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. | D M Neville | J Biol Chem | 1971 | 5127429 | Yes |
| 1357 | 1857 | 1857.0 | 0.0 | 0.0 | Cognitive maps in rats and men. | E C Tolman | Psychol Rev | 1948 | 18870876 | Yes |
| 1358 | 1856 | 1856.0 | 41.68 | 41.7 | Global cancer statistics in the year 2000. | D M Parkin | Lancet Oncol | 2001 | 11905707 | No |
| 1359 | 7415 | 1853.8 | 205.65 | 51.4 | Comorbidity measures for use with administrative data. | A Elixhauser, C Steiner, D R Harris, R M Coffey | Med Care | 1998 | 9431328 | Yes |
| 1360 | 3704 | 1852.0 | 82.26 | 41.1 | Amino acid substitution matrices from protein blocks. | S Henikoff, J G Henikoff | Proc Natl Acad Sci U S A | 1992 | 1438297 | Yes |
| 1361 | 1852 | 1852.0 | 56.02 | 56.0 | The atom economy--a search for synthetic efficiency. | B M Trost | Science | 1991 | 1962206 | Yes |
| 1362 | 1852 | 1852.0 | 41.18 | 41.2 | Fabrication of novel biomaterials through molecular self-assembly. | Shuguang Zhang | Nat Biotechnol | 2003 | 14520402 | No |
| 1363 | 1852 | 1852.0 | 50.46 | 50.5 | Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. | Ralph A Defronzo | Diabetes | 2009 | 19336687 | No |
| 1364 | 1851 | 1851.0 | 85.07 | 85.1 | Determinants of low birth weight: methodological assessment and meta-analysis. | M S Kramer | Bull World Health Organ | 1987 | 3322602 | No |
| 1365 | 3702 | 1851.0 | 76.82 | 38.4 | Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. | C D Nobes, A Hall | Cell | 1995 | 7536630 | Yes |
| 1366 | 1850 | 1850.0 | 45.26 | 45.3 | Evolutionary relationship of DNA sequences in finite populations. | F Tajima | Genetics | 1983 | 6628982 | Yes |
| 1367 | 5548 | 1849.3 | 138.78 | 46.3 | Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. | Z N Oltvai, C L Milliman, S J Korsmeyer | Cell | 1993 | 8358790 | Yes |
| 1368 | 7397 | 1849.2 | 178.81 | 44.7 | Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. | A Shevchenko, M Wilm, O Vorm, M Mann | Anal Chem | 1996 | 8779443 | Yes |
| 1369 | 3698 | 1849.0 | 142.01 | 71.0 | ROS function in redox signaling and oxidative stress. | Michael Schieber, Navdeep S Chandel | Curr Biol | 2014 | 24845678 | No |
| 1370 | 1848 | 1848.0 | 48.5 | 48.5 | The comet assay for DNA damage and repair: principles, applications, and limitations. | Andrew R Collins | Mol Biotechnol | 2004 | 15004294 | No |
| 1371 | 14771 | 1846.4 | 415.07 | 51.9 | Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. | R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A Erlich | Science | 1988 | 2448875 | Yes |
| 1372 | 3690 | 1845.0 | 99.8 | 49.9 | Biofilms: survival mechanisms of clinically relevant microorganisms. | Rodney M Donlan, J William Costerton | Clin Microbiol Rev | 2002 | 11932229 | No |
| 1373 | 3690 | 1845.0 | 52.78 | 26.4 | Immunoassay of insulin with insulin-antibody precipitate. | C N Hales, P J Randle | Biochem J | 1963 | 13952078 | Yes |
| 1374 | 3689 | 1844.5 | 105.28 | 52.6 | Molecular mechanisms and clinical applications of angiogenesis. | Peter Carmeliet, Rakesh K Jain | Nature | 2011 | 21593862 | No |
| 1375 | 1843 | 1843.0 | 52.94 | 52.9 | Perceptual symbol systems. | L W Barsalou | Behav Brain Sci | 1999 | 11301525 | No |
| 1376 | 5525 | 1841.7 | 121.96 | 40.7 | Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. | Michael W Pfaffl, Graham W Horgan, Leo Dempfle | Nucleic Acids Res | 2002 | 11972351 | Yes |
| 1377 | 1840 | 1840.0 | 45.03 | 45.0 | Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. | Fiona Turnbull | Lancet | 2003 | 14615107 | Yes |
| 1378 | 3678 | 1839.0 | 110.48 | 55.2 | New method for quantitative determination of uronic acids. | N Blumenkrantz, G Asboe-Hansen | Anal Biochem | 1973 | 4269305 | Yes |
| 1379 | 3677 | 1838.5 | 128.76 | 64.4 | miRBase: annotating high confidence microRNAs using deep sequencing data. | Ana Kozomara, Sam Griffiths-Jones | Nucleic Acids Res | 2014 | 24275495 | Yes |
| 1380 | 1838 | 1838.0 | 41.41 | 41.4 | DNA topoisomerases. | J C Wang | Annu Rev Biochem | 1996 | 8811192 | No |
| 1381 | 3674 | 1837.0 | 120.35 | 60.2 | Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. | R A DeFronzo, E Ferrannini | Diabetes Care | 1991 | 2044434 | No |
| 1382 | 7347 | 1836.8 | 340.44 | 85.1 | Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. | D J Sahn, A DeMaria, J Kisslo, A Weyman | Circulation | 1978 | 709763 | Yes |
| 1383 | 1836 | 1836.0 | 76.85 | 76.8 | Optical properties of biological tissues: a review. | Steven L Jacques | Phys Med Biol | 2013 | 23666068 | No |
| 1384 | 3671 | 1835.5 | 76.28 | 38.1 | Cell death: critical control points. | Nika N Danial, Stanley J Korsmeyer | Cell | 2004 | 14744432 | No |
| 1385 | 1835 | 1835.0 | 68.11 | 68.1 | Physiological aspects of primary hypertension. | B Folkow | Physiol Rev | 1982 | 6461865 | No |
| 1386 | 1835 | 1835.0 | 53.61 | 53.6 | phangorn: phylogenetic analysis in R. | Klaus Peter Schliep | Bioinformatics | 2011 | 21169378 | Yes |
| 1387 | 1834 | 1834.0 | 53.84 | 53.8 | Aging, cellular senescence, and cancer. | Judith Campisi | Annu Rev Physiol | 2013 | 23140366 | No |
| 1388 | 1833 | 1833.0 | 44.53 | 44.5 | A classification of hand preference by association analysis. | M Annett | Br J Psychol | 1970 | 5457503 | Yes |
| 1389 | 1833 | 1833.0 | 41.1 | 41.1 | Evolutionary rate at the molecular level. | M Kimura | Nature | 1968 | 5637732 | Yes |
| 1390 | 1833 | 1833.0 | 35.31 | 35.3 | Cancer and the chemokine network. | Fran Balkwill | Nat Rev Cancer | 2004 | 15229479 | No |
| 1391 | 1833 | 1833.0 | 36.33 | 36.3 | MicroRNA biogenesis: coordinated cropping and dicing. | V Narry Kim | Nat Rev Mol Cell Biol | 2005 | 15852042 | No |
| 1392 | 5497 | 1832.3 | 121.18 | 40.4 | A rapid method for the isolation of functional thymus-derived murine lymphocytes. | M H Julius, E Simpson, L A Herzenberg | Eur J Immunol | 1973 | 4587740 | Yes |
| 1393 | 3664 | 1832.0 | 87.9 | 44.0 | Variations in the pattern of pubertal changes in boys. | W A Marshall, J M Tanner | Arch Dis Child | 1970 | 5440182 | Yes |
| 1394 | 1832 | 1832.0 | 17.74 | 17.7 | A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. | D A Robinson | IEEE Trans Biomed Eng | 1963 | 14121113 | Yes |
| 1395 | 1831 | 1831.0 | 56.43 | 56.4 | The inverse care law. | J T Hart | Lancet | 1971 | 4100731 | Yes |
| 1396 | 10980 | 1830.0 | 320.59 | 53.4 | Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. | Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E Walters | Arch Gen Psychiatry | 2005 | 15939837 | Yes |
| 1397 | 1826 | 1826.0 | 36.56 | 36.6 | Molecular regulation of vessel maturation. | Rakesh K Jain | Nat Med | 2003 | 12778167 | No |
| 1398 | 3650 | 1825.0 | 247.38 | 123.7 | Interactive Tree Of Life (iTOL) v4: recent updates and new developments. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2019 | 30931475 | Yes |
| 1399 | 1824 | 1824.0 | 50.02 | 50.0 | Protein denaturation. | C Tanford | Adv Protein Chem | 1968 | 4882248 | No |
| 1400 | 1823 | 1823.0 | 65.96 | 66.0 | Why patients use alternative medicine: results of a national study. | J A Astin | JAMA | 1998 | 9605899 | Yes |
| 1401 | 3646 | 1823.0 | 124.76 | 62.4 | The Oswestry Disability Index. | J C Fairbank, P B Pynsent | Spine (Phila Pa 1976) | 2000 | 11074683 | No |
| 1402 | 5469 | 1823.0 | 230.6 | 76.9 | The behaviour change wheel: a new method for characterising and designing behaviour change interventions. | Susan Michie, Maartje M van Stralen, Robert West | Implement Sci | 2011 | 21513547 | No |
| 1403 | 1822 | 1822.0 | 70.05 | 70.0 | Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. | H U Wittchen | J Psychiatr Res | 1994 | 8064641 | No |
| 1404 | 1822 | 1822.0 | 51.24 | 51.2 | Oxidative stress: oxidants and antioxidants. | H Sies | Exp Physiol | 1997 | 9129943 | No |
| 1405 | 1821 | 1821.0 | 45.48 | 45.5 | Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. | B Winkel-Shirley | Plant Physiol | 2001 | 11402179 | No |
| 1406 | 1818 | 1818.0 | 49.54 | 49.5 | Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. | H LeVine | Protein Sci | 1993 | 8453378 | Yes |
| 1407 | 5443 | 1814.3 | 102.79 | 34.3 | Surfing the p53 network. | B Vogelstein, D Lane, A J Levine | Nature | 2000 | 11099028 | No |
| 1408 | 1814 | 1814.0 | 0.0 | 0.0 | The influence of some cations on an adenosine triphosphatase from peripheral nerves. | J C Skou | Biochim Biophys Acta | 1957 | 13412736 | Yes |
| 1409 | 1813 | 1813.0 | 53.8 | 53.8 | An overview of brominated flame retardants in the environment. | Cynthia A de Wit | Chemosphere | 2002 | 11999784 | No |
| 1410 | 1813 | 1813.0 | 39.79 | 39.8 | Recognition of microorganisms and activation of the immune response. | Ruslan Medzhitov | Nature | 2007 | 17943118 | No |
| 1411 | 3626 | 1813.0 | 111.01 | 55.5 | Genome editing. The new frontier of genome engineering with CRISPR-Cas9. | Jennifer A Doudna, Emmanuelle Charpentier | Science | 2014 | 25430774 | No |
| 1412 | 3624 | 1812.0 | 92.45 | 46.2 | Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. | K D McCarthy, J de Vellis | J Cell Biol | 1980 | 6248568 | Yes |
| 1413 | 1811 | 1811.0 | 55.07 | 55.1 | Social relationships and health. | Sheldon Cohen | Am Psychol | 2004 | 15554821 | No |
| 1414 | 5431 | 1810.3 | 166.25 | 55.4 | Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. | P A Wolf, R D Abbott, W B Kannel | Stroke | 1991 | 1866765 | Yes |
| 1415 | 3619 | 1809.5 | 87.3 | 43.6 | Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. | Christian Haass, Dennis J Selkoe | Nat Rev Mol Cell Biol | 2007 | 17245412 | No |
| 1416 | 1809 | 1809.0 | 59.05 | 59.0 | Heavy metal intensification of DAB-based HRP reaction product. | J C Adams | J Histochem Cytochem | 1981 | 7252134 | Yes |
| 1417 | 1809 | 1809.0 | 19.8 | 19.8 | Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. | S Cohen | J Biol Chem | 1962 | 13880319 | Yes |
| 1418 | 5426 | 1808.7 | 113.03 | 37.7 | A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. | J H Zhang, T D Chung, K R Oldenburg | J Biomol Screen | 1999 | 10838414 | Yes |
| 1419 | 3614 | 1807.0 | 101.98 | 51.0 | Receptive fields and functional architecture of monkey striate cortex. | D H Hubel, T N Wiesel | J Physiol | 1968 | 4966457 | Yes |
| 1420 | 1807 | 1807.0 | 49.07 | 49.1 | Leptospirosis. | P N Levett | Clin Microbiol Rev | 2001 | 11292640 | No |
| 1421 | 3613 | 1806.5 | 93.0 | 46.5 | Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. | M A Nitsche, W Paulus | J Physiol | 2000 | 10990547 | Yes |
| 1422 | 3612 | 1806.0 | 86.68 | 43.3 | Macrophage diversity enhances tumor progression and metastasis. | Bin-Zhi Qian, Jeffrey W Pollard | Cell | 2010 | 20371344 | No |
| 1423 | 1804 | 1804.0 | 65.95 | 66.0 | The Resonating Valence Bond State in La2CuO4 and Superconductivity. | P W Anderson | Science | 1987 | 17818979 | Yes |
| 1424 | 1804 | 1804.0 | 48.2 | 48.2 | What we can do and what we cannot do with fMRI. | Nikos K Logothetis | Nature | 2008 | 18548064 | No |
| 1425 | 1803 | 1803.0 | 42.53 | 42.5 | Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. | D Lavanchy | J Viral Hepat | 2004 | 14996343 | No |
| 1426 | 9012 | 1802.4 | 235.05 | 47.0 | Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. | Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary King | Diabetes Care | 2004 | 15111519 | Yes |
| 1427 | 1801 | 1801.0 | 56.42 | 56.4 | Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. | M Zasloff | Proc Natl Acad Sci U S A | 1987 | 3299384 | Yes |
| 1428 | 1800 | 1800.0 | 42.55 | 42.5 | Type III protein secretion systems in bacterial pathogens of animals and plants. | C J Hueck | Microbiol Mol Biol Rev | 1998 | 9618447 | No |
| 1429 | 1800 | 1800.0 | 35.44 | 35.4 | The effect of infections on susceptibility to autoimmune and allergic diseases. | Jean-Francois Bach | N Engl J Med | 2002 | 12239261 | No |
| 1430 | 5398 | 1799.3 | 142.58 | 47.5 | Median-joining networks for inferring intraspecific phylogenies. | H J Bandelt, P Forster, A Röhl | Mol Biol Evol | 1999 | 10331250 | Yes |
| 1431 | 3593 | 1796.5 | 126.62 | 63.3 | The transtheoretical model of health behavior change. | J O Prochaska, W F Velicer | Am J Health Promot | 1997 | 10170434 | No |
| 1432 | 1796 | 1796.0 | 44.03 | 44.0 | Adipose tissue, adipokines, and inflammation. | Giamila Fantuzzi | J Allergy Clin Immunol | 2005 | 15867843 | No |
| 1433 | 3592 | 1796.0 | 116.1 | 58.0 | Saliency, switching, attention and control: a network model of insula function. | Vinod Menon, Lucina Q Uddin | Brain Struct Funct | 2010 | 20512370 | No |
| 1434 | 1795 | 1795.0 | 48.06 | 48.1 | New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. | R Y Tsien | Biochemistry | 1980 | 6770893 | Yes |
| 1435 | 1795 | 1795.0 | 36.24 | 36.2 | Points of control in inflammation. | Carl Nathan | Nature | 2002 | 12490957 | No |
| 1436 | 1794 | 1794.0 | 0.0 | 0.0 | The measurement of volume changes in human limbs. | R J Whitney | J Physiol | 1953 | 13085295 | Yes |
| 1437 | 1794 | 1794.0 | 38.96 | 39.0 | The hippo signaling pathway in development and cancer. | Duojia Pan | Dev Cell | 2010 | 20951342 | No |
| 1438 | 1793 | 1793.0 | 43.03 | 43.0 | Growth of the plant cell wall. | Daniel J Cosgrove | Nat Rev Mol Cell Biol | 2005 | 16261190 | No |
| 1439 | 7170 | 1792.5 | 272.52 | 68.1 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | Int J Surg | 2010 | 20171303 | No |
| 1440 | 1791 | 1791.0 | 62.4 | 62.4 | A cortical network for directed attention and unilateral neglect. | M M Mesulam | Ann Neurol | 1981 | 7032417 | No |
| 1441 | 1790 | 1790.0 | 100.64 | 100.6 | Estimability and estimation in case-referent studies. | O Miettinen | Am J Epidemiol | 1976 | 1251836 | Yes |
| 1442 | 1790 | 1790.0 | 71.82 | 71.8 | Whatever next? Predictive brains, situated agents, and the future of cognitive science. | Andy Clark | Behav Brain Sci | 2013 | 23663408 | No |
| 1443 | 3578 | 1789.0 | 159.8 | 79.9 | Multiple receptors for dopamine. | J W Kebabian, D B Calne | Nature | 1979 | 215920 | No |
| 1444 | 1789 | 1789.0 | 18.61 | 18.6 | Chromatin structure: a repeating unit of histones and DNA. | R D Kornberg | Science | 1974 | 4825889 | Yes |
| 1445 | 1789 | 1789.0 | 36.54 | 36.5 | Structure and regulation of voltage-gated Ca2+ channels. | W A Catterall | Annu Rev Cell Dev Biol | 2000 | 11031246 | No |
| 1446 | 1789 | 1789.0 | 49.5 | 49.5 | Porous scaffold design for tissue engineering. | Scott J Hollister | Nat Mater | 2005 | 16003400 | No |
| 1447 | 3577 | 1788.5 | 85.8 | 42.9 | Protein folding in the cell. | M J Gething, J Sambrook | Nature | 1992 | 1731198 | No |
| 1448 | 3577 | 1788.5 | 71.16 | 35.6 | A guided tour into subcellular colocalization analysis in light microscopy. | S Bolte, F P Cordelières | J Microsc | 2006 | 17210054 | Yes |
| 1449 | 1788 | 1788.0 | 54.44 | 54.4 | Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4332693 | Yes |
| 1450 | 3576 | 1788.0 | 83.13 | 41.6 | The incidence of congenital heart disease. | Julien I E Hoffman, Samuel Kaplan | J Am Coll Cardiol | 2002 | 12084585 | No |
| 1451 | 3575 | 1787.5 | 181.15 | 90.6 | Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. | M Mihara, M Uchiyama | Anal Biochem | 1978 | 655387 | Yes |
| 1452 | 3575 | 1787.5 | 99.26 | 49.6 | The precuneus: a review of its functional anatomy and behavioural correlates. | Andrea E Cavanna, Michael R Trimble | Brain | 2006 | 16399806 | No |
| 1453 | 1786 | 1786.0 | 36.39 | 36.4 | Protein homology detection by HMM-HMM comparison. | Johannes Söding | Bioinformatics | 2005 | 15531603 | Yes |
| 1454 | 10713 | 1785.5 | 320.19 | 53.4 | New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. | Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier Gascuel | Syst Biol | 2010 | 20525638 | Yes |
| 1455 | 1784 | 1784.0 | 58.43 | 58.4 | The crisis in antibiotic resistance. | H C Neu | Science | 1992 | 1509257 | No |
| 1456 | 5351 | 1783.7 | 140.92 | 47.0 | The metabolic syndrome--a new worldwide definition. | K George M M Alberti, Paul Zimmet, Jonathan Shaw | Lancet | 2005 | 16182882 | Yes |
| 1457 | 8918 | 1783.6 | 296.55 | 59.3 | The hallmarks of aging. | Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer | Cell | 2013 | 23746838 | No |
| 1458 | 3566 | 1783.0 | 128.74 | 64.4 | The integrative review: updated methodology. | Robin Whittemore, Kathleen Knafl | J Adv Nurs | 2005 | 16268861 | Yes |
| 1459 | 5347 | 1782.3 | 756.82 | 252.3 | MEGA11: Molecular Evolutionary Genetics Analysis Version 11. | Koichiro Tamura, Glen Stecher, Sudhir Kumar | Mol Biol Evol | 2021 | 33892491 | Yes |
| 1460 | 7128 | 1782.0 | 138.5 | 34.6 | Stem cells, cancer, and cancer stem cells. | T Reya, S J Morrison, M F Clarke, I L Weissman | Nature | 2001 | 11689955 | No |
| 1461 | 1781 | 1781.0 | 59.22 | 59.2 | Large-scale neurocognitive networks and distributed processing for attention, language, and memory. | M M Mesulam | Ann Neurol | 1990 | 2260847 | No |
| 1462 | 1780 | 1780.0 | 32.69 | 32.7 | Cellular roles of DNA topoisomerases: a molecular perspective. | James C Wang | Nat Rev Mol Cell Biol | 2002 | 12042765 | No |
| 1463 | 12458 | 1779.7 | 300.17 | 42.9 | Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. | William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan | N Engl J Med | 2002 | 11832527 | Yes |
| 1464 | 3555 | 1777.5 | 88.05 | 44.0 | Maturation of the head of bacteriophage T4. I. DNA packaging events. | U K Laemmli, M Favre | J Mol Biol | 1973 | 4204102 | Yes |
| 1465 | 1777 | 1777.0 | 36.74 | 36.7 | Excitatory actions of gaba during development: the nature of the nurture. | Yehezkel Ben-Ari | Nat Rev Neurosci | 2002 | 12209121 | No |
| 1466 | 1776 | 1776.0 | 36.26 | 36.3 | An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. | R M Esnouf | J Mol Graph Model | 1997 | 9385560 | Yes |
| 1467 | 1776 | 1776.0 | 59.12 | 59.1 | Functional and effective connectivity: a review. | Karl J Friston | Brain Connect | 2011 | 22432952 | No |
| 1468 | 3551 | 1775.5 | 157.31 | 78.7 | The amyloid hypothesis of Alzheimer's disease at 25 years. | Dennis J Selkoe, John Hardy | EMBO Mol Med | 2016 | 27025652 | No |
| 1469 | 3546 | 1773.0 | 141.63 | 70.8 | Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. | A Y Finlay, G K Khan | Clin Exp Dermatol | 1994 | 8033378 | Yes |
| 1470 | 1773 | 1773.0 | 60.93 | 60.9 | Falls in older people: epidemiology, risk factors and strategies for prevention. | Laurence Z Rubenstein | Age Ageing | 2006 | 16926202 | No |
| 1471 | 3545 | 1772.5 | 109.65 | 54.8 | Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. | F Denizot, R Lang | J Immunol Methods | 1986 | 3486233 | Yes |
| 1472 | 3545 | 1772.5 | 70.15 | 35.1 | An automated method for finding molecular complexes in large protein interaction networks. | Gary D Bader, Christopher W V Hogue | BMC Bioinformatics | 2003 | 12525261 | Yes |
| 1473 | 1772 | 1772.0 | 36.0 | 36.0 | Oxidative stress shortens telomeres. | Thomas von Zglinicki | Trends Biochem Sci | 2002 | 12114022 | Yes |
| 1474 | 1770 | 1770.0 | 72.91 | 72.9 | Adverse health effects of high-effort/low-reward conditions. | J Siegrist | J Occup Health Psychol | 1996 | 9547031 | No |
| 1475 | 3539 | 1769.5 | 73.56 | 36.8 | Why do cancers have high aerobic glycolysis? | Robert A Gatenby, Robert J Gillies | Nat Rev Cancer | 2004 | 15516961 | No |
| 1476 | 3538 | 1769.0 | 88.5 | 44.2 | The biology of vascular endothelial growth factor. | N Ferrara, T Davis-Smyth | Endocr Rev | 1997 | 9034784 | No |
| 1477 | 1768 | 1768.0 | 58.64 | 58.6 | Drugs of abuse: anatomy, pharmacology and function of reward pathways. | G F Koob | Trends Pharmacol Sci | 1992 | 1604710 | No |
| 1478 | 3535 | 1767.5 | 134.4 | 67.2 | The Emerging Hallmarks of Cancer Metabolism. | Natalya N Pavlova, Craig B Thompson | Cell Metab | 2016 | 26771115 | No |
| 1479 | 7068 | 1767.0 | 297.7 | 74.4 | An inventory for measuring clinical anxiety: psychometric properties. | A T Beck, N Epstein, G Brown, R A Steer | J Consult Clin Psychol | 1988 | 3204199 | Yes |
| 1480 | 1767 | 1767.0 | 55.59 | 55.6 | The stress response in fish. | S E Wendelaar Bonga | Physiol Rev | 1997 | 9234959 | No |
| 1481 | 1767 | 1767.0 | 0.0 | 0.0 | The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. | S Hestrin | J Biol Chem | 1949 | 18133390 | Yes |
| 1482 | 1766 | 1766.0 | 42.22 | 42.2 | The relationship between the spleen colony-forming cell and the haemopoietic stem cell. | R Schofield | Blood Cells | 1978 | 747780 | Yes |
| 1483 | 3532 | 1766.0 | 79.73 | 39.9 | Shared principles in NF-kappaB signaling. | Matthew S Hayden, Sankar Ghosh | Cell | 2008 | 18267068 | No |
| 1484 | 7059 | 1764.8 | 232.58 | 58.1 | Common method biases in behavioral research: a critical review of the literature and recommended remedies. | Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P Podsakoff | J Appl Psychol | 2003 | 14516251 | No |
| 1485 | 1763 | 1763.0 | 0.0 | 0.0 | The recurrence of intracranial meningiomas after surgical treatment. | D Simpson | J Neurol Neurosurg Psychiatry | 1957 | 13406590 | Yes |
| 1486 | 1763 | 1763.0 | 46.46 | 46.5 | Oxidative stress and neurodegeneration: where are we now? | Barry Halliwell | J Neurochem | 2006 | 16805774 | No |
| 1487 | 17625 | 1762.5 | 552.12 | 55.2 | Measurement of protein using bicinchoninic acid. | P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C Klenk | Anal Biochem | 1985 | 3843705 | Yes |
| 1488 | 3525 | 1762.5 | 74.68 | 37.3 | Insulin signalling and the regulation of glucose and lipid metabolism. | A R Saltiel, C R Kahn | Nature | 2001 | 11742412 | Yes |
| 1489 | 12336 | 1762.3 | 412.57 | 58.9 | GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. | Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J Schünemann | BMJ | 2008 | 18436948 | Yes |
| 1490 | 1762 | 1762.0 | 50.31 | 50.3 | Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. | M J Casadaban | J Mol Biol | 1976 | 781293 | Yes |
| 1491 | 1762 | 1762.0 | 57.29 | 57.3 | Pineal melatonin: cell biology of its synthesis and of its physiological interactions. | R J Reiter | Endocr Rev | 1991 | 1649044 | No |
| 1492 | 1762 | 1762.0 | 39.02 | 39.0 | Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. | J N Dumont | J Morphol | 1972 | 4109871 | Yes |
| 1493 | 1762 | 1762.0 | 43.91 | 43.9 | Cellular basis of working memory. | P S Goldman-Rakic | Neuron | 1995 | 7695894 | No |
| 1494 | 1762 | 1762.0 | 57.06 | 57.1 | Validation of a decisional conflict scale. | A M O'Connor | Med Decis Making | 1995 | 7898294 | Yes |
| 1495 | 1761 | 1761.0 | 46.17 | 46.2 | Chlorpromazine equivalent doses for the newer atypical antipsychotics. | Scott W Woods | J Clin Psychiatry | 2003 | 12823080 | No |
| 1496 | 1760 | 1760.0 | 47.52 | 47.5 | G proteins and dual control of adenylate cyclase. | A G Gilman | Cell | 1984 | 6321035 | Yes |
| 1497 | 1760 | 1760.0 | 53.02 | 53.0 | Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. | F Rousset | Genetics | 1997 | 9093870 | Yes |
| 1498 | 3519 | 1759.5 | 88.46 | 44.2 | Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. | S Schulman, C Kearon | J Thromb Haemost | 2005 | 15842354 | Yes |
| 1499 | 3518 | 1759.0 | 45.62 | 22.8 | A complementation analysis of the restriction and modification of DNA in Escherichia coli. | H W Boyer, D Roulland-Dussoix | J Mol Biol | 1969 | 4896022 | Yes |
| 1500 | 1759 | 1759.0 | 65.99 | 66.0 | Simple proton spectroscopic imaging. | W T Dixon | Radiology | 1984 | 6089263 | Yes |
| 1501 | 1759 | 1759.0 | 42.26 | 42.3 | Clinical application of C-reactive protein for cardiovascular disease detection and prevention. | Paul M Ridker | Circulation | 2003 | 12551853 | No |
| 1502 | 1758 | 1758.0 | 46.53 | 46.5 | Interleukin-6: an overview. | J Van Snick | Annu Rev Immunol | 1990 | 2188664 | No |
| 1503 | 1758 | 1758.0 | 66.47 | 66.5 | Selenium and human health. | Margaret P Rayman | Lancet | 2012 | 22381456 | No |
| 1504 | 1757 | 1757.0 | 40.85 | 40.9 | Areas, volumes, packing and protein structure. | F M Richards | Annu Rev Biophys Bioeng | 1977 | 326146 | No |
| 1505 | 3514 | 1757.0 | 86.55 | 43.3 | Matrix metalloproteinases. | H Nagase, J F Woessner | J Biol Chem | 1999 | 10419448 | No |
| 1506 | 3512 | 1756.0 | 95.97 | 48.0 | Protective and pathogenic functions of macrophage subsets. | Peter J Murray, Thomas A Wynn | Nat Rev Immunol | 2011 | 21997792 | No |
| 1507 | 1755 | 1755.0 | 42.59 | 42.6 | Why genes in pieces? | W Gilbert | Nature | 1978 | 622185 | Yes |
| 1508 | 1755 | 1755.0 | 41.61 | 41.6 | Tricine-SDS-PAGE. | Hermann Schägger | Nat Protoc | 2006 | 17406207 | Yes |
| 1509 | 3509 | 1754.5 | 89.89 | 44.9 | Regulation of chromatin by histone modifications. | Andrew J Bannister, Tony Kouzarides | Cell Res | 2011 | 21321607 | No |
| 1510 | 1754 | 1754.0 | 40.1 | 40.1 | Steroid receptor regulated transcription of specific genes and gene networks. | K R Yamamoto | Annu Rev Genet | 1985 | 3909942 | No |
| 1511 | 3508 | 1754.0 | 104.26 | 52.1 | The pathogenesis of rheumatoid arthritis. | Iain B McInnes, Georg Schett | N Engl J Med | 2011 | 22150039 | No |
| 1512 | 1754 | 1754.0 | 133.65 | 133.7 | User's guide to correlation coefficients. | Haldun Akoglu | Turk J Emerg Med | 2018 | 30191186 | No |
| 1513 | 1753 | 1753.0 | 70.66 | 70.7 | Macrophage Polarization. | Peter J Murray | Annu Rev Physiol | 2017 | 27813830 | No |
| 1514 | 3504 | 1752.0 | 0.0 | 0.0 | Convergent and discriminant validation by the multitrait-multimethod matrix. | D T Campbell, D W Fiske | Psychol Bull | 1959 | 13634291 | Yes |
| 1515 | 3503 | 1751.5 | 82.74 | 41.4 | Origins and Mechanisms of miRNAs and siRNAs. | Richard W Carthew, Erik J Sontheimer | Cell | 2009 | 19239886 | No |
| 1516 | 1751 | 1751.0 | 61.1 | 61.1 | The role of hormone receptors and GTP-regulatory proteins in membrane transduction. | M Rodbell | Nature | 1980 | 6101906 | Yes |
| 1517 | 3500 | 1750.0 | 92.76 | 46.4 | Prediction of protein antigenic determinants from amino acid sequences. | T P Hopp, K R Woods | Proc Natl Acad Sci U S A | 1981 | 6167991 | Yes |
| 1518 | 1750 | 1750.0 | 32.97 | 33.0 | Network motifs: theory and experimental approaches. | Uri Alon | Nat Rev Genet | 2007 | 17510665 | No |
| 1519 | 5245 | 1748.3 | 117.95 | 39.3 | Inflammation and atherosclerosis. | Peter Libby, Paul M Ridker, Attilio Maseri | Circulation | 2002 | 11877368 | No |
| 1520 | 1748 | 1748.0 | 38.63 | 38.6 | The synaptic vesicle cycle: a cascade of protein-protein interactions. | T C Südhof | Nature | 1995 | 7791897 | No |
| 1521 | 3495 | 1747.5 | 163.79 | 81.9 | Making sense of Cronbach's alpha. | Mohsen Tavakol, Reg Dennick | Int J Med Educ | 2011 | 28029643 | No |
| 1522 | 1747 | 1747.0 | 44.44 | 44.4 | The pathophysiology of tumor necrosis factors. | P Vassalli | Annu Rev Immunol | 1992 | 1590993 | No |
| 1523 | 1747 | 1747.0 | 0.0 | 0.0 | A personality scale of manifest anxiety. | J A Taylor | J Abnorm Psychol | 1953 | 13052352 | Yes |
| 1524 | 1745 | 1745.0 | 37.87 | 37.9 | ATPase activity of myosin correlated with speed of muscle shortening. | M Bárány | J Gen Physiol | 1967 | 4227924 | Yes |
| 1525 | 3490 | 1745.0 | 92.39 | 46.2 | The mirror-neuron system. | Giacomo Rizzolatti, Laila Craighero | Annu Rev Neurosci | 2004 | 15217330 | No |
| 1526 | 1745 | 1745.0 | 33.61 | 33.6 | Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. | Judith Campisi | Cell | 2005 | 15734683 | No |
| 1527 | 3489 | 1744.5 | 70.33 | 35.2 | A general framework for weighted gene co-expression network analysis. | Bin Zhang, Steve Horvath | Stat Appl Genet Mol Biol | 2005 | 16646834 | Yes |
| 1528 | 1744 | 1744.0 | 42.16 | 42.2 | Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. | Z Yang | J Mol Evol | 1994 | 7932792 | Yes |
| 1529 | 1744 | 1744.0 | 46.88 | 46.9 | Oxidative stress hypothesis in Alzheimer's disease. | W R Markesbery | Free Radic Biol Med | 1997 | 9165306 | No |
| 1530 | 3486 | 1743.0 | 179.54 | 89.8 | Interrater reliability of a modified Ashworth scale of muscle spasticity. | R W Bohannon, M B Smith | Phys Ther | 1987 | 3809245 | Yes |
| 1531 | 1743 | 1743.0 | 69.46 | 69.5 | Sample size in qualitative research. | M Sandelowski | Res Nurs Health | 1995 | 7899572 | Yes |
| 1532 | 13940 | 1742.5 | 401.98 | 50.2 | The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. | Ziad S Nasreddine, Natalie A Phillips, Valérie Bédirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard Chertkow | J Am Geriatr Soc | 2005 | 15817019 | Yes |
| 1533 | 3483 | 1741.5 | 150.43 | 75.2 | A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. | J G Snodgrass, M Vanderwart | J Exp Psychol Hum Learn | 1980 | 7373248 | Yes |
| 1534 | 5223 | 1741.0 | 134.7 | 44.9 | The rapid generation of mutation data matrices from protein sequences. | D T Jones, W R Taylor, J M Thornton | Comput Appl Biosci | 1992 | 1633570 | Yes |
| 1535 | 3482 | 1741.0 | 135.77 | 67.9 | Assays of glutathione peroxidase. | L Flohé, W A Günzler | Methods Enzymol | 1984 | 6727659 | Yes |
| 1536 | 3481 | 1740.5 | 72.98 | 36.5 | Integrin signaling. | F G Giancotti, E Ruoslahti | Science | 1999 | 10446041 | No |
| 1537 | 3481 | 1740.5 | 98.43 | 49.2 | Alzheimer's disease. | Henry W Querfurth, Frank M LaFerla | N Engl J Med | 2010 | 20107219 | No |
| 1538 | 6961 | 1740.2 | 136.0 | 34.0 | Transformation of intact yeast cells treated with alkali cations. | H Ito, Y Fukuda, K Murata, A Kimura | J Bacteriol | 1983 | 6336730 | Yes |
| 1539 | 1739 | 1739.0 | 40.63 | 40.6 | Solvent-accessible surfaces of proteins and nucleic acids. | M L Connolly | Science | 1983 | 6879170 | Yes |
| 1540 | 1738 | 1738.0 | 65.15 | 65.2 | Antibiotics in the aquatic environment--a review--part I. | Klaus Kümmerer | Chemosphere | 2009 | 19185900 | No |
| 1541 | 1737 | 1737.0 | 73.89 | 73.9 | Dynamic properties of mammalian skeletal muscles. | R I Close | Physiol Rev | 1972 | 4256989 | No |
| 1542 | 8677 | 1735.4 | 197.45 | 39.5 | Stages of embryonic development of the zebrafish. | C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F Schilling | Dev Dyn | 1995 | 8589427 | Yes |
| 1543 | 1735 | 1735.0 | 56.68 | 56.7 | Serum albumin. | T Peters | Adv Protein Chem | 1985 | 3904348 | No |
| 1544 | 1735 | 1735.0 | 38.88 | 38.9 | Tumor angiogenesis. | Robert S Kerbel | N Engl J Med | 2008 | 18463380 | No |
| 1545 | 1733 | 1733.0 | 62.56 | 62.6 | Cyclosporine. | B D Kahan | N Engl J Med | 1989 | 2687689 | No |
| 1546 | 1733 | 1733.0 | 50.02 | 50.0 | Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. | E M Wassermann | Electroencephalogr Clin Neurophysiol | 1998 | 9474057 | No |
| 1547 | 1733 | 1733.0 | 37.31 | 37.3 | Trastuzumab--mechanism of action and use in clinical practice. | Clifford A Hudis | N Engl J Med | 2007 | 17611206 | No |
| 1548 | 1732 | 1732.0 | 39.47 | 39.5 | Mode of cell migration to the superficial layers of fetal monkey neocortex. | P Rakic | J Comp Neurol | 1972 | 4624784 | Yes |
| 1549 | 1732 | 1732.0 | 54.19 | 54.2 | Glutamate: a neurotransmitter in mammalian brain. | F Fonnum | J Neurochem | 1984 | 6139418 | No |
| 1550 | 3464 | 1732.0 | 74.36 | 37.2 | Fibroblasts in cancer. | Raghu Kalluri, Michael Zeisberg | Nat Rev Cancer | 2006 | 16572188 | No |
| 1551 | 8653 | 1730.6 | 213.32 | 42.7 | Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. | Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan Hsu | N Engl J Med | 2004 | 15385656 | Yes |
| 1552 | 1730 | 1730.0 | 59.39 | 59.4 | Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? | B Halliwell | Lancet | 1994 | 7915779 | No |
| 1553 | 3460 | 1730.0 | 138.33 | 69.2 | Methods for the thematic synthesis of qualitative research in systematic reviews. | James Thomas, Angela Harden | BMC Med Res Methodol | 2008 | 18616818 | Yes |
| 1554 | 5188 | 1729.3 | 112.38 | 37.5 | Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. | A Nicholls, K A Sharp, B Honig | Proteins | 1991 | 1758883 | Yes |
| 1555 | 1729 | 1729.0 | 40.91 | 40.9 | Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. | A Krishan | J Cell Biol | 1975 | 49354 | Yes |
| 1556 | 3458 | 1729.0 | 93.92 | 47.0 | Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. | K B Mullis, F A Faloona | Methods Enzymol | 1987 | 3431465 | Yes |
| 1557 | 3458 | 1729.0 | 90.66 | 45.3 | Cloned glutamate receptors. | M Hollmann, S Heinemann | Annu Rev Neurosci | 1994 | 8210177 | No |
| 1558 | 1728 | 1728.0 | 37.39 | 37.4 | Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. | A F Habeeb | Anal Biochem | 1966 | 4161471 | Yes |
| 1559 | 1727 | 1727.0 | 56.27 | 56.3 | The polyvagal perspective. | Stephen W Porges | Biol Psychol | 2007 | 17049418 | No |
| 1560 | 8632 | 1726.4 | 324.8 | 65.0 | UCHIME improves sensitivity and speed of chimera detection. | Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob Knight | Bioinformatics | 2011 | 21700674 | Yes |
| 1561 | 1726 | 1726.0 | 60.83 | 60.8 | Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. | M Wong-Riley | Brain Res | 1979 | 223730 | Yes |
| 1562 | 5176 | 1725.3 | 135.3 | 45.1 | A neural substrate of prediction and reward. | W Schultz, P Dayan, P R Montague | Science | 1997 | 9054347 | No |
| 1563 | 3449 | 1724.5 | 131.52 | 65.8 | The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. | A J Stunkard, S Messick | J Psychosom Res | 1985 | 3981480 | Yes |
| 1564 | 1724 | 1724.0 | 57.82 | 57.8 | Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. | E M Witkin | Bacteriol Rev | 1976 | 795416 | No |
| 1565 | 1724 | 1724.0 | 45.67 | 45.7 | THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. | Kozi Asada | Annu Rev Plant Physiol Plant Mol Biol | 1999 | 15012221 | Yes |
| 1566 | 1723 | 1723.0 | 37.6 | 37.6 | AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. | D Grahame Hardie | Nat Rev Mol Cell Biol | 2007 | 17712357 | No |
| 1567 | 1722 | 1722.0 | 31.06 | 31.1 | CD4+ CD25+ suppressor T cells: more questions than answers. | Ethan M Shevach | Nat Rev Immunol | 2002 | 12093005 | No |
| 1568 | 5166 | 1722.0 | 185.46 | 61.8 | Multiple imputation using chained equations: Issues and guidance for practice. | Ian R White, Patrick Royston, Angela M Wood | Stat Med | 2011 | 21225900 | Yes |
| 1569 | 1721 | 1721.0 | 0.0 | 0.0 | Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. | J Spizizen | Proc Natl Acad Sci U S A | 1958 | 16590310 | Yes |
| 1570 | 1721 | 1721.0 | 46.91 | 46.9 | The origins of the developmental origins theory. | D J P Barker | J Intern Med | 2007 | 17444880 | No |
| 1571 | 3442 | 1721.0 | 113.12 | 56.6 | Neutrophil recruitment and function in health and inflammation. | Elzbieta Kolaczkowska, Paul Kubes | Nat Rev Immunol | 2013 | 23435331 | No |
| 1572 | 5162 | 1720.7 | 231.15 | 77.0 | Some statistical methods useful in circulation research. | S Wallenstein, C L Zucker, J L Fleiss | Circ Res | 1980 | 7379260 | Yes |
| 1573 | 3441 | 1720.5 | 104.07 | 52.0 | The benefits of being present: mindfulness and its role in psychological well-being. | Kirk Warren Brown, Richard M Ryan | J Pers Soc Psychol | 2003 | 12703651 | Yes |
| 1574 | 5160 | 1720.0 | 154.78 | 51.6 | Simultaneous inference in general parametric models. | Torsten Hothorn, Frank Bretz, Peter Westfall | Biom J | 2008 | 18481363 | No |
| 1575 | 6878 | 1719.5 | 197.46 | 49.4 | The validity of the Hospital Anxiety and Depression Scale. An updated literature review. | Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag Neckelmann | J Psychosom Res | 2002 | 11832252 | No |
| 1576 | 1718 | 1718.0 | 56.49 | 56.5 | Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. | C E Mogensen | N Engl J Med | 1984 | 6690964 | Yes |
| 1577 | 1717 | 1717.0 | 61.63 | 61.6 | Modeling Development and Disease with Organoids. | Hans Clevers | Cell | 2016 | 27315476 | No |
| 1578 | 3433 | 1716.5 | 86.57 | 43.3 | Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. | Steven E Nissen, Kathy Wolski | N Engl J Med | 2007 | 17517853 | Yes |
| 1579 | 1715 | 1715.0 | 70.45 | 70.5 | Responses to depression and their effects on the duration of depressive episodes. | S Nolen-Hoeksema | J Abnorm Psychol | 1991 | 1757671 | No |
| 1580 | 5144 | 1714.7 | 168.14 | 56.0 | A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. | J R Le Gall, S Lemeshow, F Saulnier | JAMA | 1993 | 8254858 | Yes |
| 1581 | 1714 | 1714.0 | 40.43 | 40.4 | Two pathogenetic types of endometrial carcinoma. | J V Bokhman | Gynecol Oncol | 1983 | 6822361 | Yes |
| 1582 | 5140 | 1713.3 | 161.29 | 53.8 | Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. | H Esterbauer, R J Schaur, H Zollner | Free Radic Biol Med | 1991 | 1937131 | No |
| 1583 | 1713 | 1713.0 | 38.53 | 38.5 | Effects of cytochalasin and phalloidin on actin. | J A Cooper | J Cell Biol | 1987 | 3312229 | No |
| 1584 | 1713 | 1713.0 | 59.52 | 59.5 | Computerized transverse axial scanning (tomography). 1. Description of system. | G N Hounsfield | Br J Radiol | 1973 | 4757352 | Yes |
| 1585 | 1713 | 1713.0 | 44.57 | 44.6 | Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. | G C Walker | Microbiol Rev | 1984 | 6371470 | No |
| 1586 | 1713 | 1713.0 | 51.42 | 51.4 | Constructions of masculinity and their influence on men's well-being: a theory of gender and health. | W H Courtenay | Soc Sci Med | 2000 | 10741575 | No |
| 1587 | 1713 | 1713.0 | 56.6 | 56.6 | Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. | Lutz Ackermann | Chem Rev | 2011 | 21391562 | Yes |
| 1588 | 1712 | 1712.0 | 64.8 | 64.8 | Modeling and variable selection in epidemiologic analysis. | S Greenland | Am J Public Health | 1989 | 2916724 | Yes |
| 1589 | 1712 | 1712.0 | 41.92 | 41.9 | The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. | R Ross | J Cell Biol | 1971 | 4327464 | Yes |
| 1590 | 1712 | 1712.0 | 32.79 | 32.8 | Generating samples under a Wright-Fisher neutral model of genetic variation. | Richard R Hudson | Bioinformatics | 2002 | 11847089 | Yes |
| 1591 | 1711 | 1711.0 | 31.38 | 31.4 | How eukaryotic transcriptional activators work. | M Ptashne | Nature | 1988 | 3050531 | No |
| 1592 | 5132 | 1710.7 | 112.83 | 37.6 | An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. | J K Eng, A L McCormack, J R Yates | J Am Soc Mass Spectrom | 1994 | 24226387 | Yes |
| 1593 | 1710 | 1710.0 | 33.52 | 33.5 | The synaptic vesicle cycle. | Thomas C Sudhof | Annu Rev Neurosci | 2004 | 15217342 | No |
| 1594 | 1710 | 1710.0 | 0.0 | 0.0 | The general adaptation syndrome and the diseases of adaptation. | H Selye | J Clin Endocrinol Metab | 1946 | 21025115 | Yes |
| 1595 | 3419 | 1709.5 | 95.98 | 48.0 | Astrocytes: biology and pathology. | Michael V Sofroniew, Harry V Vinters | Acta Neuropathol | 2010 | 20012068 | No |
| 1596 | 3418 | 1709.0 | 86.42 | 43.2 | Quantum dot bioconjugates for ultrasensitive nonisotopic detection. | W C Chan, S Nie | Science | 1998 | 9748158 | Yes |
| 1597 | 3417 | 1708.5 | 82.44 | 41.2 | The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. | A E Bolton, W M Hunter | Biochem J | 1973 | 4733239 | Yes |
| 1598 | 3416 | 1708.0 | 110.02 | 55.0 | Separate visual pathways for perception and action. | M A Goodale, A D Milner | Trends Neurosci | 1992 | 1374953 | No |
| 1599 | 3415 | 1707.5 | 149.93 | 75.0 | A fluorometric method for determination of oxidized and reduced glutathione in tissues. | P J Hissin, R Hilf | Anal Biochem | 1976 | 962076 | Yes |
| 1600 | 17073 | 1707.3 | 541.77 | 54.2 | The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. | F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S Luthra | Arthritis Rheum | 1988 | 3358796 | Yes |
| 1601 | 1707 | 1707.0 | 68.65 | 68.7 | Negative symptoms in schizophrenia. Definition and reliability. | N C Andreasen | Arch Gen Psychiatry | 1982 | 7165477 | Yes |
| 1602 | 3410 | 1705.0 | 222.81 | 111.4 | The structure of coping. | L I Pearlin, C Schooler | J Health Soc Behav | 1978 | 649936 | Yes |
| 1603 | 3410 | 1705.0 | 128.34 | 64.2 | A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. | J A Horne, O Ostberg | Int J Chronobiol | 1976 | 1027738 | Yes |
| 1604 | 1705 | 1705.0 | 52.39 | 52.4 | A measure of population subdivision based on microsatellite allele frequencies. | M Slatkin | Genetics | 1995 | 7705646 | Yes |
| 1605 | 1705 | 1705.0 | 38.43 | 38.4 | Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. | S A Bustin | J Mol Endocrinol | 2002 | 12200227 | No |
| 1606 | 6816 | 1704.0 | 143.42 | 35.9 | Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. | E A Jaffe, R L Nachman, C G Becker, C R Minick | J Clin Invest | 1973 | 4355998 | Yes |
| 1607 | 1704 | 1704.0 | 0.0 | 0.0 | Note on the sampling error of the difference between correlated proportions or percentages. | Q McNEMAR | Psychometrika | 1947 | 20254758 | Yes |
| 1608 | 5110 | 1703.3 | 119.98 | 40.0 | Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. | Prateek Kumar, Steven Henikoff, Pauline C Ng | Nat Protoc | 2009 | 19561590 | Yes |
| 1609 | 1703 | 1703.0 | 31.17 | 31.2 | Transplacental carcinogenesis by stilbestrol. | J Folkman | N Engl J Med | 1971 | 5556579 | Yes |
| 1610 | 1703 | 1703.0 | 39.21 | 39.2 | PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. | Michael F. Thomashow | Annu Rev Plant Physiol Plant Mol Biol | 1999 | 15012220 | Yes |
| 1611 | 1703 | 1703.0 | 36.8 | 36.8 | The NCI60 human tumour cell line anticancer drug screen. | Robert H Shoemaker | Nat Rev Cancer | 2006 | 16990858 | No |
| 1612 | 3405 | 1702.5 | 78.4 | 39.2 | The BCL-2 protein family: opposing activities that mediate cell death. | Richard J Youle, Andreas Strasser | Nat Rev Mol Cell Biol | 2008 | 18097445 | No |
| 1613 | 1701 | 1701.0 | 45.23 | 45.2 | Synergy, antagonism, and what the chequerboard puts between them. | F C Odds | J Antimicrob Chemother | 2003 | 12805255 | No |
| 1614 | 3402 | 1701.0 | 118.43 | 59.2 | A "Direct-Coloring" Thiocholine Method For Cholinesterases. | M J Karnovsky, L Roots | J Histochem Cytochem | 1964 | 14187330 | Yes |
| 1615 | 3401 | 1700.5 | 92.34 | 46.2 | Bronchopulmonary dysplasia. | A H Jobe, E Bancalari | Am J Respir Crit Care Med | 2001 | 11401896 | No |
| 1616 | 3401 | 1700.5 | 87.77 | 43.9 | Multiple sclerosis. | Alastair Compston, Alasdair Coles | Lancet | 2008 | 18970977 | Yes |
| 1617 | 1700 | 1700.0 | 39.52 | 39.5 | Angiogenesis: an organizing principle for drug discovery? | Judah Folkman | Nat Rev Drug Discov | 2007 | 17396134 | No |
| 1618 | 1700 | 1700.0 | 78.63 | 78.6 | Neutrophil extracellular traps in immunity and disease. | Venizelos Papayannopoulos | Nat Rev Immunol | 2018 | 28990587 | No |
| 1619 | 1699 | 1699.0 | 41.37 | 41.4 | The statistical analysis of enzyme kinetic data. | W W Cleland | Adv Enzymol Relat Areas Mol Biol | 1967 | 4881884 | No |
| 1620 | 10188 | 1698.0 | 284.22 | 47.4 | Positional cloning of the mouse obese gene and its human homologue. | Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M Friedman | Nature | 1994 | 7984236 | Yes |
| 1621 | 1698 | 1698.0 | 34.38 | 34.4 | Neurotrophins and their receptors: a convergence point for many signalling pathways. | Moses V Chao | Nat Rev Neurosci | 2003 | 12671646 | No |
| 1622 | 1697 | 1697.0 | 42.87 | 42.9 | Carbonic anhydrase: chemistry, physiology, and inhibition. | T H Maren | Physiol Rev | 1967 | 4964060 | No |
| 1623 | 3394 | 1697.0 | 107.75 | 53.9 | Neurocircuitry of addiction. | George F Koob, Nora D Volkow | Neuropsychopharmacology | 2010 | 19710631 | No |
| 1624 | 1696 | 1696.0 | 75.89 | 75.9 | The micronucleus test. | W Schmid | Mutat Res | 1975 | 48190 | Yes |
| 1625 | 3392 | 1696.0 | 81.24 | 40.6 | CAP3: A DNA sequence assembly program. | X Huang, A Madan | Genome Res | 1999 | 10508846 | Yes |
| 1626 | 6782 | 1695.5 | 195.79 | 48.9 | Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. | B Biswal, F Z Yetkin, V M Haughton, J S Hyde | Magn Reson Med | 1995 | 8524021 | Yes |
| 1627 | 1695 | 1695.0 | 31.19 | 31.2 | Cyclin-dependent kinases: engines, clocks, and microprocessors. | D O Morgan | Annu Rev Cell Dev Biol | 1997 | 9442875 | No |
| 1628 | 1695 | 1695.0 | 35.99 | 36.0 | Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. | S L Friedman | J Biol Chem | 2000 | 10644669 | No |
| 1629 | 1695 | 1695.0 | 18.25 | 18.2 | Impulses and Physiological States in Theoretical Models of Nerve Membrane. | R Fitzhugh | Biophys J | 1961 | 19431309 | Yes |
| 1630 | 1695 | 1695.0 | 52.0 | 52.0 | Stress and disorders of the stress system. | George P Chrousos | Nat Rev Endocrinol | 2009 | 19488073 | No |
| 1631 | 1694 | 1694.0 | 38.83 | 38.8 | A graphic method for the determination and presentation of binding parameters in a complex system. | H E Rosenthal | Anal Biochem | 1967 | 6048188 | Yes |
| 1632 | 3387 | 1693.5 | 93.68 | 46.8 | Biochemistry of multidrug resistance mediated by the multidrug transporter. | M M Gottesman, I Pastan | Annu Rev Biochem | 1993 | 8102521 | No |
| 1633 | 5074 | 1691.3 | 109.27 | 36.4 | Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. | J E Darnell, I M Kerr, G R Stark | Science | 1994 | 8197455 | No |
| 1634 | 1691 | 1691.0 | 45.3 | 45.3 | Integrins. | E Ruoslahti | J Clin Invest | 1991 | 1985087 | No |
| 1635 | 1691 | 1691.0 | 51.59 | 51.6 | Pedigrees of some mutant strains of Escherichia coli K-12. | B J Bachmann | Bacteriol Rev | 1972 | 4568763 | No |
| 1636 | 1691 | 1691.0 | 39.02 | 39.0 | A revolution in optical manipulation. | David G Grier | Nature | 2003 | 12917694 | No |
| 1637 | 1691 | 1691.0 | 53.14 | 53.1 | Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. | Joseph J Volpe | Lancet Neurol | 2009 | 19081519 | No |
| 1638 | 8454 | 1690.8 | 91.53 | 18.3 | Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. | S Katz, A B Ford, R W Moskowitz, B A Jackson, M W Jaffe | JAMA | 1963 | 14044222 | Yes |
| 1639 | 1690 | 1690.0 | 54.6 | 54.6 | Synaptic density in human frontal cortex - developmental changes and effects of aging. | P R Huttenlocher | Brain Res | 1979 | 427544 | Yes |
| 1640 | 1690 | 1690.0 | 58.67 | 58.7 | Cytokines in inflammatory bowel disease. | Markus F Neurath | Nat Rev Immunol | 2014 | 24751956 | No |
| 1641 | 3378 | 1689.0 | 125.61 | 62.8 | The mini-mental state examination: a comprehensive review. | T N Tombaugh, N J McIntyre | J Am Geriatr Soc | 1992 | 1512391 | No |
| 1642 | 1688 | 1688.0 | 40.24 | 40.2 | The molecular genetics of cancer. | J M Bishop | Science | 1987 | 3541204 | No |
| 1643 | 3375 | 1687.5 | 92.32 | 46.2 | A perspective on cancer cell metastasis. | Christine L Chaffer, Robert A Weinberg | Science | 2011 | 21436443 | No |
| 1644 | 6748 | 1687.0 | 265.5 | 66.4 | 16S ribosomal DNA amplification for phylogenetic study. | W G Weisburg, S M Barns, D A Pelletier, D J Lane | J Bacteriol | 1991 | 1987160 | Yes |
| 1645 | 1687 | 1687.0 | 69.46 | 69.5 | Plastic Embedding Mixtures For Use In Electron Microscopy. | H H Mollenhauer | Stain Technol | 1964 | 14127791 | Yes |
| 1646 | 3374 | 1687.0 | 71.61 | 35.8 | The epigenomics of cancer. | Peter A Jones, Stephen B Baylin | Cell | 2007 | 17320506 | No |
| 1647 | 1687 | 1687.0 | 36.65 | 36.6 | Perceptions of epigenetics. | Adrian Bird | Nature | 2007 | 17522671 | Yes |
| 1648 | 3373 | 1686.5 | 70.18 | 35.1 | Fitting a mixture model by expectation maximization to discover motifs in biopolymers. | T L Bailey, C Elkan | Proc Int Conf Intell Syst Mol Biol | 1994 | 7584402 | Yes |
| 1649 | 1686 | 1686.0 | 20.11 | 20.1 | Amino acid difference formula to help explain protein evolution. | R Grantham | Science | 1974 | 4843792 | Yes |
| 1650 | 3372 | 1686.0 | 83.63 | 41.8 | Receptors for purines and pyrimidines. | V Ralevic, G Burnstock | Pharmacol Rev | 1998 | 9755289 | No |
| 1651 | 3372 | 1686.0 | 68.95 | 34.5 | 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? | George Davey Smith, Shah Ebrahim | Int J Epidemiol | 2003 | 12689998 | No |
| 1652 | 1686 | 1686.0 | 0.0 | 0.0 | The theory and applications of the exchange of inert gas at the lungs and tissues. | S S Kety | Pharmacol Rev | 1951 | 14833874 | Yes |
| 1653 | 3371 | 1685.5 | 98.94 | 49.5 | An information-maximization approach to blind separation and blind deconvolution. | A J Bell, T J Sejnowski | Neural Comput | 1995 | 7584893 | Yes |
| 1654 | 6740 | 1685.0 | 205.6 | 51.4 | The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. | S P Baker, B O'Neill, W Haddon, W B Long | J Trauma | 1974 | 4814394 | Yes |
| 1655 | 1684 | 1684.0 | 39.86 | 39.9 | The failing heart--an engine out of fuel. | Stefan Neubauer | N Engl J Med | 2007 | 17360992 | No |
| 1656 | 3367 | 1683.5 | 69.78 | 34.9 | A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. | D Wessel, U I Flügge | Anal Biochem | 1984 | 6731838 | Yes |
| 1657 | 1683 | 1683.0 | 81.55 | 81.5 | Hydrogel: Preparation, characterization, and applications: A review. | Enas M Ahmed | J Adv Res | 2015 | 25750745 | No |
| 1658 | 3366 | 1683.0 | 139.22 | 69.6 | Parkinson's disease. | Lorraine V Kalia, Anthony E Lang | Lancet | 2015 | 25904081 | No |
| 1659 | 1682 | 1682.0 | 41.25 | 41.2 | Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. | Shitij Kapur | Am J Psychiatry | 2003 | 12505794 | No |
| 1660 | 3362 | 1681.0 | 82.85 | 41.4 | Protein structure prediction on the Web: a case study using the Phyre server. | Lawrence A Kelley, Michael J E Sternberg | Nat Protoc | 2009 | 19247286 | Yes |
| 1661 | 1680 | 1680.0 | 38.62 | 38.6 | NADPH oxidase: an update. | B M Babior | Blood | 1999 | 10029572 | No |
| 1662 | 1679 | 1679.0 | 62.4 | 62.4 | Paced auditory serial-addition task: a measure of recovery from concussion. | D M Gronwall | Percept Mot Skills | 1977 | 866038 | Yes |
| 1663 | 1679 | 1679.0 | 32.89 | 32.9 | Hox genes in vertebrate development. | R Krumlauf | Cell | 1994 | 7913880 | No |
| 1664 | 1679 | 1679.0 | 30.99 | 31.0 | Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. | M G Gustafsson | J Microsc | 2000 | 10810003 | Yes |
| 1665 | 6715 | 1678.8 | 222.41 | 55.6 | SignalP 4.0: discriminating signal peptides from transmembrane regions. | Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik Nielsen | Nat Methods | 2011 | 21959131 | Yes |
| 1666 | 1678 | 1678.0 | 39.51 | 39.5 | Five rules for the evolution of cooperation. | Martin A Nowak | Science | 2006 | 17158317 | No |
| 1667 | 1677 | 1677.0 | 64.4 | 64.4 | Probiotics in man and animals. | R Fuller | J Appl Bacteriol | 1989 | 2666378 | No |
| 1668 | 1677 | 1677.0 | 49.22 | 49.2 | Drugs which inhibit prostaglandin biosynthesis. | R J Flower | Pharmacol Rev | 1974 | 4208101 | Yes |
| 1669 | 1677 | 1677.0 | 58.36 | 58.4 | Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. | A H Conney | Cancer Res | 1982 | 6814745 | No |
| 1670 | 1677 | 1677.0 | 14.05 | 14.1 | Chromatographic Separation Of Human Brain Gangliosides. | L Svennerholm | J Neurochem | 1963 | 14066623 | Yes |
| 1671 | 1677 | 1677.0 | 35.99 | 36.0 | Hematopoietic stem-cell transplantation. | Edward A Copelan | N Engl J Med | 2006 | 16641398 | No |
| 1672 | 1677 | 1677.0 | 50.16 | 50.2 | Stress signalling pathways that impair prefrontal cortex structure and function. | Amy F T Arnsten | Nat Rev Neurosci | 2009 | 19455173 | No |
| 1673 | 5029 | 1676.3 | 198.63 | 66.2 | The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. | C A McHorney, J E Ware, A E Raczek | Med Care | 1993 | 8450681 | Yes |
| 1674 | 1676 | 1676.0 | 47.07 | 47.1 | The in vitro micronucleus technique. | M Fenech | Mutat Res | 2000 | 11113469 | No |
| 1675 | 1676 | 1676.0 | 42.42 | 42.4 | The importance of the ratio of omega-6/omega-3 essential fatty acids. | A P Simopoulos | Biomed Pharmacother | 2002 | 12442909 | No |
| 1676 | 1676 | 1676.0 | 46.32 | 46.3 | Multiple imputation of discrete and continuous data by fully conditional specification. | Stef van Buuren | Stat Methods Med Res | 2007 | 17621469 | Yes |
| 1677 | 1676 | 1676.0 | 50.6 | 50.6 | Apoptosis in cancer: from pathogenesis to treatment. | Rebecca S Y Wong | J Exp Clin Cancer Res | 2011 | 21943236 | No |
| 1678 | 1675 | 1675.0 | 59.0 | 59.0 | Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). | G G Glenner | N Engl J Med | 1980 | 6154243 | No |
| 1679 | 3350 | 1675.0 | 78.28 | 39.1 | Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. | Robert Visse, Hideaki Nagase | Circ Res | 2003 | 12730128 | No |
| 1680 | 10049 | 1674.8 | 204.82 | 34.1 | Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. | A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C Mello | Nature | 1998 | 9486653 | Yes |
| 1681 | 3348 | 1674.0 | 216.8 | 108.4 | A clinical method of functional assessment of the shoulder. | C R Constant, A H Murley | Clin Orthop Relat Res | 1987 | 3791738 | Yes |
| 1682 | 1674 | 1674.0 | 45.06 | 45.1 | Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. | J A Miller | Cancer Res | 1970 | 4915745 | No |
| 1683 | 1674 | 1674.0 | 81.04 | 81.0 | International classification of sleep disorders-third edition: highlights and modifications. | Michael J Sateia | Chest | 2014 | 25367475 | No |
| 1684 | 3347 | 1673.5 | 79.08 | 39.5 | The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. | P Angel, M Karin | Biochim Biophys Acta | 1991 | 1751545 | No |
| 1685 | 5019 | 1673.0 | 262.88 | 87.6 | Impact of Event Scale: a measure of subjective stress. | M Horowitz, N Wilner, W Alvarez | Psychosom Med | 1979 | 472086 | Yes |
| 1686 | 1673 | 1673.0 | 42.71 | 42.7 | Understanding biofilm resistance to antibacterial agents. | David Davies | Nat Rev Drug Discov | 2003 | 12563302 | No |
| 1687 | 1673 | 1673.0 | 37.23 | 37.2 | Introduction to NF-kappaB: players, pathways, perspectives. | T D Gilmore | Oncogene | 2006 | 17072321 | No |
| 1688 | 1672 | 1672.0 | 30.74 | 30.7 | Neuroblastoma: biological insights into a clinical enigma. | Garrett M Brodeur | Nat Rev Cancer | 2003 | 12612655 | No |
| 1689 | 1671 | 1671.0 | 38.27 | 38.3 | The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. | D M Kingsley | Genes Dev | 1994 | 8299934 | No |
| 1690 | 5011 | 1670.3 | 289.72 | 96.6 | SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. | Antoine Daina, Olivier Michielin, Vincent Zoete | Sci Rep | 2017 | 28256516 | Yes |
| 1691 | 18372 | 1670.2 | 574.57 | 52.2 | A new equation to estimate glomerular filtration rate. | Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef Coresh | Ann Intern Med | 2009 | 19414839 | Yes |
| 1692 | 1670 | 1670.0 | 82.39 | 82.4 | Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. | K O Fagerström | Addict Behav | 1978 | 735910 | Yes |
| 1693 | 1670 | 1670.0 | 46.33 | 46.3 | Understanding organofluorine chemistry. An introduction to the C-F bond. | David O'Hagan | Chem Soc Rev | 2008 | 18197347 | No |
| 1694 | 1670 | 1670.0 | 46.89 | 46.9 | The many roles for fluorine in medicinal chemistry. | William K Hagmann | J Med Chem | 2008 | 18570365 | Yes |
| 1695 | 3339 | 1669.5 | 109.77 | 54.9 | Role of free radicals and catalytic metal ions in human disease: an overview. | B Halliwell, J M Gutteridge | Methods Enzymol | 1990 | 2172697 | No |
| 1696 | 3339 | 1669.5 | 53.79 | 26.9 | Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. | J Marmur, P Doty | J Mol Biol | 1962 | 14470099 | Yes |
| 1697 | 1668 | 1668.0 | 68.08 | 68.1 | A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. | D J Schuirmann | J Pharmacokinet Biopharm | 1987 | 3450848 | Yes |
| 1698 | 1668 | 1668.0 | 53.36 | 53.4 | The global impact of pre-eclampsia and eclampsia. | Lelia Duley | Semin Perinatol | 2009 | 19464502 | No |
| 1699 | 1667 | 1667.0 | 31.79 | 31.8 | Simple memory: a theory for archicortex. | D Marr | Philos Trans R Soc Lond B Biol Sci | 1971 | 4399412 | Yes |
| 1700 | 1667 | 1667.0 | 0.0 | 0.0 | Method for the determination of hexosamines in tissues. | N F Boas | J Biol Chem | 1953 | 13117829 | Yes |
| 1701 | 1667 | 1667.0 | 0.0 | 0.0 | Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. | E G Gray | J Anat | 1959 | 13829103 | Yes |
| 1702 | 3332 | 1666.0 | 78.41 | 39.2 | Adipose tissue as an endocrine organ. | Erin E Kershaw, Jeffrey S Flier | J Clin Endocrinol Metab | 2004 | 15181022 | No |
| 1703 | 1665 | 1665.0 | 59.79 | 59.8 | Dual-task interference in simple tasks: data and theory. | H Pashler | Psychol Bull | 1994 | 7972591 | No |
| 1704 | 1665 | 1665.0 | 32.27 | 32.3 | Cell cycle checkpoints: preventing an identity crisis. | S J Elledge | Science | 1996 | 8939848 | No |
| 1705 | 1664 | 1664.0 | 52.59 | 52.6 | Metallothionein. | D H Hamer | Annu Rev Biochem | 1986 | 3527054 | No |
| 1706 | 1664 | 1664.0 | 46.66 | 46.7 | Semiempirical hybrid density functional with perturbative second-order correlation. | Stefan Grimme | J Chem Phys | 2006 | 16438568 | Yes |
| 1707 | 1664 | 1664.0 | 47.1 | 47.1 | Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. | James J P Stewart | J Mol Model | 2007 | 17828561 | Yes |
| 1708 | 1663 | 1663.0 | 54.73 | 54.7 | Number of people with glaucoma worldwide. | H A Quigley | Br J Ophthalmol | 1996 | 8695555 | No |
| 1709 | 1663 | 1663.0 | 39.74 | 39.7 | Inflammatory bowel disease: etiology and pathogenesis. | C Fiocchi | Gastroenterology | 1998 | 9649475 | No |
| 1710 | 1661 | 1661.0 | 37.74 | 37.7 | In vivo near-infrared fluorescence imaging. | John V Frangioni | Curr Opin Chem Biol | 2003 | 14580568 | No |
| 1711 | 1661 | 1661.0 | 50.41 | 50.4 | Chlorophyll fluorescence: a probe of photosynthesis in vivo. | Neil R Baker | Annu Rev Plant Biol | 2008 | 18444897 | No |
| 1712 | 3321 | 1660.5 | 87.23 | 43.6 | Molecular mechanisms of long noncoding RNAs. | Kevin C Wang, Howard Y Chang | Mol Cell | 2011 | 21925379 | No |
| 1713 | 1659 | 1659.0 | 74.11 | 74.1 | The structure and properties of the sense of coherence scale. | A Antonovsky | Soc Sci Med | 1993 | 8480217 | Yes |
| 1714 | 1659 | 1659.0 | 35.56 | 35.6 | An approximately unbiased test of phylogenetic tree selection. | Hidetoshi Shimodaira | Syst Biol | 2002 | 12079646 | Yes |
| 1715 | 1658 | 1658.0 | 45.4 | 45.4 | An improved procedure for serum creatine phosphokinase determination. | S B Rosalki | J Lab Clin Med | 1967 | 4381359 | Yes |
| 1716 | 3316 | 1658.0 | 66.74 | 33.4 | Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. | Gary L Johnson, Razvan Lapadat | Science | 2002 | 12471242 | No |
| 1717 | 3313 | 1656.5 | 128.79 | 64.4 | The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. | T Omura, R Sato | J Biol Chem | 1964 | 14209972 | Yes |
| 1718 | 3313 | 1656.5 | 83.99 | 42.0 | ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. | Markus Wiederstein, Manfred J Sippl | Nucleic Acids Res | 2007 | 17517781 | Yes |
| 1719 | 3312 | 1656.0 | 83.63 | 41.8 | Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. | M Grunstein, D S Hogness | Proc Natl Acad Sci U S A | 1975 | 1105573 | Yes |
| 1720 | 1656 | 1656.0 | 23.8 | 23.8 | RNA-dependent DNA polymerase in virions of RNA tumour viruses. | D Baltimore | Nature | 1970 | 4316300 | Yes |
| 1721 | 11592 | 1656.0 | 342.57 | 48.9 | AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. | Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J Olson | J Comput Chem | 2009 | 19399780 | Yes |
| 1722 | 3310 | 1655.0 | 66.35 | 33.2 | Upstream and downstream of mTOR. | Nissim Hay, Nahum Sonenberg | Genes Dev | 2004 | 15314020 | No |
| 1723 | 3310 | 1655.0 | 154.98 | 77.5 | Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2016 | 27095192 | Yes |
| 1724 | 3308 | 1654.0 | 58.75 | 29.4 | Method for the isolation of intact islets of Langerhans from the rat pancreas. | P E Lacy, M Kostianovsky | Diabetes | 1967 | 5333500 | Yes |
| 1725 | 1654 | 1654.0 | 41.85 | 41.9 | Neurotrophins and neuronal plasticity. | H Thoenen | Science | 1995 | 7570017 | No |
| 1726 | 1654 | 1654.0 | 196.47 | 196.5 | COVID-19 and mental health: A review of the existing literature. | Ravi Philip Rajkumar | Asian J Psychiatr | 2020 | 32302935 | Yes |
| 1727 | 6613 | 1653.2 | 152.51 | 38.1 | Use of T7 RNA polymerase to direct expression of cloned genes. | F W Studier, A H Rosenberg, J J Dunn, J W Dubendorff | Methods Enzymol | 1990 | 2199796 | Yes |
| 1728 | 1651 | 1651.0 | 31.05 | 31.1 | Switching and signaling at the telomere. | E H Blackburn | Cell | 2001 | 11572773 | No |
| 1729 | 1650 | 1650.0 | 57.13 | 57.1 | The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. | E J Khantzian | Harv Rev Psychiatry | 1997 | 9385000 | No |
| 1730 | 1650 | 1650.0 | 33.21 | 33.2 | DNA in a material world. | Nadrian C Seeman | Nature | 2003 | 12540916 | No |
| 1731 | 1650 | 1650.0 | 53.58 | 53.6 | The role of senescent cells in ageing. | Jan M van Deursen | Nature | 2014 | 24848057 | No |
| 1732 | 6597 | 1649.2 | 287.43 | 71.9 | A rating scale for mania: reliability, validity and sensitivity. | R C Young, J T Biggs, V E Ziegler, D A Meyer | Br J Psychiatry | 1978 | 728692 | Yes |
| 1733 | 1649 | 1649.0 | 57.91 | 57.9 | The linear-quadratic formula and progress in fractionated radiotherapy. | J F Fowler | Br J Radiol | 1989 | 2670032 | No |
| 1734 | 3296 | 1648.0 | 75.11 | 37.6 | Human mesenchymal stem cells modulate allogeneic immune cell responses. | Sudeepta Aggarwal, Mark F Pittenger | Blood | 2005 | 15494428 | Yes |
| 1735 | 1647 | 1647.0 | 46.96 | 47.0 | The basal ganglia: focused selection and inhibition of competing motor programs. | J W Mink | Prog Neurobiol | 1996 | 9004351 | No |
| 1736 | 9881 | 1646.8 | 227.73 | 38.0 | Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. | D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuire | Science | 1987 | 3798106 | Yes |
| 1737 | 3293 | 1646.5 | 63.55 | 31.8 | The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. | J O'Keefe, J Dostrovsky | Brain Res | 1971 | 5124915 | Yes |
| 1738 | 1646 | 1646.0 | 42.72 | 42.7 | Alpha-crystallin can function as a molecular chaperone. | J Horwitz | Proc Natl Acad Sci U S A | 1992 | 1438232 | Yes |
| 1739 | 3290 | 1645.0 | 71.35 | 35.7 | Protein structure comparison by alignment of distance matrices. | L Holm, C Sander | J Mol Biol | 1993 | 8377180 | Yes |
| 1740 | 3289 | 1644.5 | 68.34 | 34.2 | The Ki-67 protein: from the known and the unknown. | T Scholzen, J Gerdes | J Cell Physiol | 2000 | 10653597 | No |
| 1741 | 4933 | 1644.3 | 116.8 | 38.9 | Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. | Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck Ørntoft | Cancer Res | 2004 | 15289330 | Yes |
| 1742 | 1644 | 1644.0 | 53.96 | 54.0 | Archaea in coastal marine environments. | E F DeLong | Proc Natl Acad Sci U S A | 1992 | 1608980 | Yes |
| 1743 | 1644 | 1644.0 | 73.05 | 73.0 | Mood and memory. | G H Bower | Am Psychol | 1981 | 7224324 | Yes |
| 1744 | 1644 | 1644.0 | 34.75 | 34.8 | Neuronal calcium signaling. | M J Berridge | Neuron | 1998 | 9697848 | No |
| 1745 | 1643 | 1643.0 | 42.84 | 42.8 | Task switching. | Stephen Monsell | Trends Cogn Sci | 2003 | 12639695 | Yes |
| 1746 | 1642 | 1642.0 | 48.57 | 48.6 | Classification of inflammatory bowel disease. | J E Lennard-Jones | Scand J Gastroenterol Suppl | 1989 | 2617184 | Yes |
| 1747 | 1642 | 1642.0 | 45.22 | 45.2 | Turnover of inositol phospholipids and signal transduction. | Y Nishizuka | Science | 1984 | 6147898 | No |
| 1748 | 4925 | 1641.7 | 103.68 | 34.6 | Adjusting batch effects in microarray expression data using empirical Bayes methods. | W Evan Johnson, Cheng Li, Ariel Rabinovic | Biostatistics | 2007 | 16632515 | Yes |
| 1749 | 1641 | 1641.0 | 48.67 | 48.7 | Extracellular ATP: effects, sources and fate. | J L Gordon | Biochem J | 1986 | 3006665 | No |
| 1750 | 3281 | 1640.5 | 117.18 | 58.6 | Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. | M M Bradley, P J Lang | J Behav Ther Exp Psychiatry | 1994 | 7962581 | Yes |
| 1751 | 1640 | 1640.0 | 49.56 | 49.6 | Ordinary magic. Resilience processes in development. | A S Masten | Am Psychol | 2001 | 11315249 | Yes |
| 1752 | 1640 | 1640.0 | 40.51 | 40.5 | Marine viruses--major players in the global ecosystem. | Curtis A Suttle | Nat Rev Microbiol | 2007 | 17853907 | No |
| 1753 | 1640 | 1640.0 | 66.79 | 66.8 | Structure, Function, and Evolution of Coronavirus Spike Proteins. | Fang Li | Annu Rev Virol | 2016 | 27578435 | No |
| 1754 | 1638 | 1638.0 | 57.33 | 57.3 | The case-crossover design: a method for studying transient effects on the risk of acute events. | M Maclure | Am J Epidemiol | 1991 | 1985444 | Yes |
| 1755 | 1637 | 1637.0 | 37.29 | 37.3 | Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. | S C Manolagas | Endocr Rev | 2000 | 10782361 | No |
| 1756 | 3272 | 1636.0 | 85.01 | 42.5 | Early identification of refractory epilepsy. | P Kwan, M J Brodie | N Engl J Med | 2000 | 10660394 | Yes |
| 1757 | 1635 | 1635.0 | 29.07 | 29.1 | Maximum-likelihood density modification. | T C Terwilliger | Acta Crystallogr D Biol Crystallogr | 2000 | 10944333 | Yes |
| 1758 | 1635 | 1635.0 | 40.74 | 40.7 | External validity of randomised controlled trials: "to whom do the results of this trial apply?". | Peter M Rothwell | Lancet | 2005 | 15639683 | Yes |
| 1759 | 4903 | 1634.3 | 95.23 | 31.7 | T-Coffee: A novel method for fast and accurate multiple sequence alignment. | C Notredame, D G Higgins, J Heringa | J Mol Biol | 2000 | 10964570 | Yes |
| 1760 | 1634 | 1634.0 | 33.25 | 33.2 | Structural features in eukaryotic mRNAs that modulate the initiation of translation. | M Kozak | J Biol Chem | 1991 | 1939050 | No |
| 1761 | 3265 | 1632.5 | 99.44 | 49.7 | How good are my data and what is the resolution? | Philip R Evans, Garib N Murshudov | Acta Crystallogr D Biol Crystallogr | 2013 | 23793146 | Yes |
| 1762 | 3264 | 1632.0 | 101.32 | 50.7 | Neoantigens in cancer immunotherapy. | Ton N Schumacher, Robert D Schreiber | Science | 2015 | 25838375 | No |
| 1763 | 1631 | 1631.0 | 56.62 | 56.6 | Frontal-subcortical circuits and human behavior. | J L Cummings | Arch Neurol | 1993 | 8352676 | No |
| 1764 | 1630 | 1630.0 | 40.51 | 40.5 | A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. | D Mattingly | J Clin Pathol | 1962 | 14471419 | Yes |
| 1765 | 1628 | 1628.0 | 70.95 | 71.0 | Neurogenetic adaptive mechanisms in alcoholism. | C R Cloninger | Science | 1987 | 2882604 | Yes |
| 1766 | 1628 | 1628.0 | 58.35 | 58.4 | Aging, natural death, and the compression of morbidity. | J F Fries | N Engl J Med | 1980 | 7383070 | Yes |
| 1767 | 1628 | 1628.0 | 49.74 | 49.7 | Efficient analysis of experimental observations. | W J Dixon | Annu Rev Pharmacol Toxicol | 1980 | 7387124 | Yes |
| 1768 | 1628 | 1628.0 | 34.61 | 34.6 | Bone morphogenetic proteins: multifunctional regulators of vertebrate development. | B L Hogan | Genes Dev | 1996 | 8682290 | No |
| 1769 | 1627 | 1627.0 | 50.95 | 51.0 | Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. | D W Choi | Trends Neurosci | 1988 | 2469166 | No |
| 1770 | 1627 | 1627.0 | 42.46 | 42.5 | Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. | D A Dougherty | Science | 1996 | 8539615 | No |
| 1771 | 1627 | 1627.0 | 40.06 | 40.1 | Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. | M J Meaney | Annu Rev Neurosci | 2001 | 11520931 | No |
| 1772 | 3254 | 1627.0 | 72.39 | 36.2 | ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. | Matthew D Wilkerson, D Neil Hayes | Bioinformatics | 2010 | 20427518 | Yes |
| 1773 | 1626 | 1626.0 | 45.44 | 45.4 | Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. | B Hille | J Gen Physiol | 1977 | 300786 | Yes |
| 1774 | 1626 | 1626.0 | 52.66 | 52.7 | Asthma phenotypes: the evolution from clinical to molecular approaches. | Sally E Wenzel | Nat Med | 2012 | 22561835 | No |
| 1775 | 1625 | 1625.0 | 58.07 | 58.1 | Cell damage in the brain: a speculative synthesis. | B K Siesjö | J Cereb Blood Flow Metab | 1981 | 6276420 | No |
| 1776 | 6497 | 1624.2 | 220.71 | 55.2 | Guidelines for the process of cross-cultural adaptation of self-report measures. | D E Beaton, C Bombardier, F Guillemin, M B Ferraz | Spine (Phila Pa 1976) | 2000 | 11124735 | No |
| 1777 | 3248 | 1624.0 | 89.31 | 44.7 | Diarrheagenic Escherichia coli. | J P Nataro, J B Kaper | Clin Microbiol Rev | 1998 | 9457432 | No |
| 1778 | 9739 | 1623.2 | 337.64 | 56.3 | Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. | L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R Tannenbaum | Anal Biochem | 1982 | 7181105 | Yes |
| 1779 | 1623 | 1623.0 | 22.81 | 22.8 | Structural considerations in the interaction of DNA and acridines. | L S Lerman | J Mol Biol | 1961 | 13761054 | Yes |
| 1780 | 1621 | 1621.0 | 51.95 | 52.0 | Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). | M N Marsh | Gastroenterology | 1992 | 1727768 | No |
| 1781 | 1621 | 1621.0 | 56.13 | 56.1 | Interhemispheric differences in the localization of psychological processes in man. | B Milner | Br Med Bull | 1971 | 4937273 | No |
| 1782 | 1621 | 1621.0 | 0.0 | 0.0 | Cerebral blood flow and oxygen consumption in man. | N A Lassen | Physiol Rev | 1959 | 13645234 | Yes |
| 1783 | 1620 | 1620.0 | 46.41 | 46.4 | Fluorescence energy transfer as a spectroscopic ruler. | L Stryer | Annu Rev Biochem | 1978 | 354506 | No |
| 1784 | 1620 | 1620.0 | 56.46 | 56.5 | Multimodal approach to control postoperative pathophysiology and rehabilitation. | H Kehlet | Br J Anaesth | 1997 | 9175983 | No |
| 1785 | 3239 | 1619.5 | 76.76 | 38.4 | Rapid and sensitive protein similarity searches. | D J Lipman, W R Pearson | Science | 1985 | 2983426 | Yes |
| 1786 | 1619 | 1619.0 | 27.54 | 27.5 | Cell cycle checkpoint signaling through the ATM and ATR kinases. | R T Abraham | Genes Dev | 2001 | 11544175 | No |
| 1787 | 3237 | 1618.5 | 96.37 | 48.2 | Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. | M Karas, F Hillenkamp | Anal Chem | 1988 | 3239801 | Yes |
| 1788 | 1618 | 1618.0 | 47.61 | 47.6 | Metalloproteinases and their inhibitors in matrix remodeling. | L M Matrisian | Trends Genet | 1990 | 2132731 | No |
| 1789 | 1618 | 1618.0 | 30.21 | 30.2 | Germinal centers. | I C MacLennan | Annu Rev Immunol | 1994 | 8011279 | No |
| 1790 | 1618 | 1618.0 | 37.06 | 37.1 | Neurovascular regulation in the normal brain and in Alzheimer's disease. | Costantino Iadecola | Nat Rev Neurosci | 2004 | 15100718 | No |
| 1791 | 1618 | 1618.0 | 37.99 | 38.0 | The blood-brain barrier: bottleneck in brain drug development. | William M Pardridge | NeuroRx | 2005 | 15717053 | No |
| 1792 | 1617 | 1617.0 | 39.53 | 39.5 | Recognition of errors in three-dimensional structures of proteins. | M J Sippl | Proteins | 1993 | 8108378 | Yes |
| 1793 | 1617 | 1617.0 | 30.44 | 30.4 | Protein kinases--the major drug targets of the twenty-first century? | Philip Cohen | Nat Rev Drug Discov | 2002 | 12120282 | No |
| 1794 | 3234 | 1617.0 | 103.16 | 51.6 | The future of immune checkpoint therapy. | Padmanee Sharma, James P Allison | Science | 2015 | 25838373 | No |
| 1795 | 1614 | 1614.0 | 45.6 | 45.6 | Ionic dependence of glutamate neurotoxicity. | D W Choi | J Neurosci | 1987 | 2880938 | Yes |
| 1796 | 1614 | 1614.0 | 39.38 | 39.4 | The genetical evolution of social behaviour. II. | W D Hamilton | J Theor Biol | 1964 | 5875340 | Yes |
| 1797 | 1614 | 1614.0 | 44.6 | 44.6 | Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. | P A Bradford | Clin Microbiol Rev | 2001 | 11585791 | No |
| 1798 | 1614 | 1614.0 | 45.03 | 45.0 | Gold-catalyzed organic reactions. | A Stephen K Hashmi | Chem Rev | 2007 | 17580975 | Yes |
| 1799 | 3227 | 1613.5 | 98.02 | 49.0 | Oxidative stress and diabetic complications. | Ferdinando Giacco, Michael Brownlee | Circ Res | 2010 | 21030723 | No |
| 1800 | 1613 | 1613.0 | 33.95 | 34.0 | The caveolae membrane system. | R G Anderson | Annu Rev Biochem | 1998 | 9759488 | No |
| 1801 | 1613 | 1613.0 | 36.08 | 36.1 | The Unified Medical Language System (UMLS): integrating biomedical terminology. | Olivier Bodenreider | Nucleic Acids Res | 2004 | 14681409 | Yes |
| 1802 | 1613 | 1613.0 | 75.0 | 75.0 | Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. | Kevin A Hallgren | Tutor Quant Methods Psychol | 2012 | 22833776 | Yes |
| 1803 | 1612 | 1612.0 | 30.99 | 31.0 | The microRNA Registry. | Sam Griffiths-Jones | Nucleic Acids Res | 2004 | 14681370 | Yes |
| 1804 | 1612 | 1612.0 | 47.48 | 47.5 | A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. | Ozcan Erel | Clin Biochem | 2004 | 15003729 | Yes |
| 1805 | 1612 | 1612.0 | 0.0 | 0.0 | Application of a Theory of Enzyme Specificity to Protein Synthesis. | D E Koshland | Proc Natl Acad Sci U S A | 1958 | 16590179 | Yes |
| 1806 | 1610 | 1610.0 | 80.76 | 80.8 | Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. | F E Zajac | Crit Rev Biomed Eng | 1989 | 2676342 | No |
| 1807 | 1609 | 1609.0 | 31.65 | 31.6 | Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. | D I Svergun | Biophys J | 1999 | 10354416 | Yes |
| 1808 | 1608 | 1608.0 | 42.57 | 42.6 | A more meaningful scoring system for determining the severity of coronary heart disease. | G G Gensini | Am J Cardiol | 1983 | 6823874 | Yes |
| 1809 | 3216 | 1608.0 | 71.28 | 35.6 | Lipopolysaccharide endotoxins. | Christian R H Raetz, Chris Whitfield | Annu Rev Biochem | 2002 | 12045108 | No |
| 1810 | 3216 | 1608.0 | 124.74 | 62.4 | Alginate: properties and biomedical applications. | Kuen Yong Lee, David J Mooney | Prog Polym Sci | 2012 | 22125349 | Yes |
| 1811 | 3214 | 1607.0 | 62.59 | 31.3 | The evolutionary fate and consequences of duplicate genes. | M Lynch, J S Conery | Science | 2000 | 11073452 | No |
| 1812 | 3214 | 1607.0 | 66.32 | 33.2 | Signaling to NF-kappaB. | Matthew S Hayden, Sankar Ghosh | Genes Dev | 2004 | 15371334 | No |
| 1813 | 11245 | 1606.4 | 312.15 | 44.6 | BLAST+: architecture and applications. | Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L Madden | BMC Bioinformatics | 2009 | 20003500 | Yes |
| 1814 | 3210 | 1605.0 | 83.47 | 41.7 | Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. | D B Dill, D L Costill | J Appl Physiol | 1974 | 4850854 | Yes |
| 1815 | 1605 | 1605.0 | 63.69 | 63.7 | Nonalcoholic fatty liver disease: a systematic review. | Mary E Rinella | JAMA | 2015 | 26057287 | No |
| 1816 | 3209 | 1604.5 | 62.11 | 31.1 | Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. | M E Greenberg, E B Ziff | Nature | 1984 | 6090941 | Yes |
| 1817 | 3207 | 1603.5 | 76.69 | 38.3 | Cell signaling by receptor tyrosine kinases. | Mark A Lemmon, Joseph Schlessinger | Cell | 2010 | 20602996 | No |
| 1818 | 1602 | 1602.0 | 36.82 | 36.8 | VLA proteins in the integrin family: structures, functions, and their role on leukocytes. | M E Hemler | Annu Rev Immunol | 1990 | 2188667 | No |
| 1819 | 3204 | 1602.0 | 113.45 | 56.7 | Avoiding false positives with PCR. | S Kwok, R Higuchi | Nature | 1989 | 2716852 | Yes |
| 1820 | 1602 | 1602.0 | 50.92 | 50.9 | Cellular defenses against damage from reactive oxygen species. | B P Yu | Physiol Rev | 1994 | 8295932 | No |
| 1821 | 1602 | 1602.0 | 39.04 | 39.0 | The corticosteroid receptor hypothesis of depression. | F Holsboer | Neuropsychopharmacology | 2000 | 11027914 | No |
| 1822 | 1602 | 1602.0 | 35.86 | 35.9 | Hypertrophic cardiomyopathy: a systematic review. | Barry J Maron | JAMA | 2002 | 11886323 | No |
| 1823 | 3204 | 1602.0 | 169.56 | 84.8 | Natural Products as Sources of New Drugs from 1981 to 2014. | David J Newman, Gordon M Cragg | J Nat Prod | 2016 | 26852623 | No |
| 1824 | 4805 | 1601.7 | 126.43 | 42.1 | Fast model-based estimation of ancestry in unrelated individuals. | David H Alexander, John Novembre, Kenneth Lange | Genome Res | 2009 | 19648217 | Yes |
| 1825 | 3203 | 1601.5 | 94.96 | 47.5 | Unified approach for molecular dynamics and density-functional theory. | R Car, M Parrinello | Phys Rev Lett | 1985 | 10032153 | Yes |
| 1826 | 3202 | 1601.0 | 61.78 | 30.9 | Automated MAD and MIR structure solution. | T C Terwilliger, J Berendzen | Acta Crystallogr D Biol Crystallogr | 1999 | 10089316 | Yes |
| 1827 | 1600 | 1600.0 | 36.44 | 36.4 | Getting formal with dopamine and reward. | Wolfram Schultz | Neuron | 2002 | 12383780 | No |
| 1828 | 1600 | 1600.0 | 0.0 | 0.0 | Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. | O Ouchterlony | Acta Pathol Microbiol Scand | 1953 | 13079779 | Yes |
| 1829 | 3199 | 1599.5 | 99.84 | 49.9 | Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. | G R Gibson, M B Roberfroid | J Nutr | 1995 | 7782892 | No |
| 1830 | 1599 | 1599.0 | 40.84 | 40.8 | Molecular biology of prion diseases. | S B Prusiner | Science | 1991 | 1675487 | No |
| 1831 | 1599 | 1599.0 | 36.22 | 36.2 | Cellular oncogenes and retroviruses. | J M Bishop | Annu Rev Biochem | 1983 | 6351725 | No |
| 1832 | 1599 | 1599.0 | 42.29 | 42.3 | Precision mapping of quantitative trait loci. | Z B Zeng | Genetics | 1994 | 8013918 | Yes |
| 1833 | 1598 | 1598.0 | 34.42 | 34.4 | On finding all suboptimal foldings of an RNA molecule. | M Zuker | Science | 1989 | 2468181 | No |
| 1834 | 1598 | 1598.0 | 45.84 | 45.8 | The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. | R R Llinás | Science | 1988 | 3059497 | No |
| 1835 | 3196 | 1598.0 | 62.63 | 31.3 | NF-kappaB regulation in the immune system. | Qiutang Li, Inder M Verma | Nat Rev Immunol | 2002 | 12360211 | No |
| 1836 | 9588 | 1598.0 | 225.33 | 37.6 | GROMACS: fast, flexible, and free. | David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C Berendsen | J Comput Chem | 2005 | 16211538 | Yes |
| 1837 | 1598 | 1598.0 | 36.85 | 36.9 | Insulin and insulin-like growth factor signalling in neoplasia. | Michael Pollak | Nat Rev Cancer | 2008 | 19029956 | No |
| 1838 | 19170 | 1597.5 | 781.81 | 65.2 | Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. | Sue Richards, Nazneen Aziz, Sherri Bale, David Bick, Soma Das, Julie Gastier-Foster, Wayne W Grody, Madhuri Hegde, Elaine Lyon, Elaine Spector, Karl Voelkerding, Heidi L Rehm | Genet Med | 2015 | 25741868 | No |
| 1839 | 1597 | 1597.0 | 31.52 | 31.5 | An analysis of vertebrate mRNA sequences: intimations of translational control. | M Kozak | J Cell Biol | 1991 | 1955461 | No |
| 1840 | 1597 | 1597.0 | 30.61 | 30.6 | The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. | A G Pearse | J Histochem Cytochem | 1969 | 4143745 | No |
| 1841 | 1597 | 1597.0 | 72.44 | 72.4 | Measurement of health state utilities for economic appraisal. | G W Torrance | J Health Econ | 1986 | 10311607 | No |
| 1842 | 1596 | 1596.0 | 57.35 | 57.4 | Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. | P Holzer | Pharmacol Rev | 1991 | 1852779 | No |
| 1843 | 1596 | 1596.0 | 71.1 | 71.1 | The contribution of low birth weight to infant mortality and childhood morbidity. | M C McCormick | N Engl J Med | 1985 | 3880598 | No |
| 1844 | 3192 | 1596.0 | 89.22 | 44.6 | Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. | Sally S Dickerson, Margaret E Kemeny | Psychol Bull | 2004 | 15122924 | Yes |
| 1845 | 3191 | 1595.5 | 67.41 | 33.7 | Inhibitors of mammalian G1 cyclin-dependent kinases. | C J Sherr, J M Roberts | Genes Dev | 1995 | 7758941 | No |
| 1846 | 1595 | 1595.0 | 48.94 | 48.9 | The role of the amygdala in fear and anxiety. | M Davis | Annu Rev Neurosci | 1992 | 1575447 | No |
| 1847 | 1595 | 1595.0 | 28.82 | 28.8 | Altering the genome by homologous recombination. | M R Capecchi | Science | 1989 | 2660260 | No |
| 1848 | 1595 | 1595.0 | 36.84 | 36.8 | A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. | D A Gewirtz | Biochem Pharmacol | 1999 | 10075079 | No |
| 1849 | 1595 | 1595.0 | 40.51 | 40.5 | Aspergillus fumigatus and aspergillosis. | J P Latgé | Clin Microbiol Rev | 1999 | 10194462 | No |
| 1850 | 1594 | 1594.0 | 30.53 | 30.5 | Regulatory T cells, tumour immunity and immunotherapy. | Weiping Zou | Nat Rev Immunol | 2006 | 16557261 | No |
| 1851 | 9562 | 1593.7 | 269.3 | 44.9 | A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. | Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier | Science | 2012 | 22745249 | Yes |
| 1852 | 3187 | 1593.5 | 77.52 | 38.8 | A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. | S Tabor, C C Richardson | Proc Natl Acad Sci U S A | 1985 | 3156376 | Yes |
| 1853 | 3187 | 1593.5 | 87.92 | 44.0 | Polyamines. | C W Tabor, H Tabor | Annu Rev Biochem | 1984 | 6206782 | No |
| 1854 | 1593 | 1593.0 | 39.23 | 39.2 | Tumor necrosis factor (TNF). | L J Old | Science | 1985 | 2413547 | Yes |
| 1855 | 1593 | 1593.0 | 30.92 | 30.9 | Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. | R K Jain | Nat Med | 2001 | 11533692 | No |
| 1856 | 3186 | 1593.0 | 65.19 | 32.6 | Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. | E Krissinel, K Henrick | Acta Crystallogr D Biol Crystallogr | 2004 | 15572779 | Yes |
| 1857 | 4777 | 1592.3 | 130.66 | 43.6 | Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. | M Hasegawa, H Kishino, T Yano | J Mol Evol | 1985 | 3934395 | Yes |
| 1858 | 4776 | 1592.0 | 116.15 | 38.7 | Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. | Earl S Ford, Wayne H Giles, William H Dietz | JAMA | 2002 | 11790215 | Yes |
| 1859 | 3184 | 1592.0 | 92.78 | 46.4 | Density functionals with broad applicability in chemistry. | Yan Zhao, Donald G Truhlar | Acc Chem Res | 2008 | 18186612 | Yes |
| 1860 | 3183 | 1591.5 | 69.09 | 34.5 | Neurotrophins: roles in neuronal development and function. | E J Huang, L F Reichardt | Annu Rev Neurosci | 2001 | 11520916 | No |
| 1861 | 1591 | 1591.0 | 38.26 | 38.3 | Clinical features of metastatic bone disease and risk of skeletal morbidity. | Robert E Coleman | Clin Cancer Res | 2006 | 17062708 | No |
| 1862 | 3182 | 1591.0 | 117.64 | 58.8 | Elements of cancer immunity and the cancer-immune set point. | Daniel S Chen, Ira Mellman | Nature | 2017 | 28102259 | No |
| 1863 | 1590 | 1590.0 | 34.47 | 34.5 | Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. | G L Semenza | Annu Rev Cell Dev Biol | 1999 | 10611972 | No |
| 1864 | 1590 | 1590.0 | 36.97 | 37.0 | Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults. | Bei-Fan Zhou | Biomed Environ Sci | 2002 | 12046553 | Yes |
| 1865 | 1590 | 1590.0 | 60.02 | 60.0 | A Protection Motivation Theory of Fear Appeals and Attitude Change1. | Ronald W Rogers | J Psychol | 1975 | 28136248 | Yes |
| 1866 | 3179 | 1589.5 | 75.3 | 37.6 | Unravelling the pathogenesis of inflammatory bowel disease. | R J Xavier, D K Podolsky | Nature | 2007 | 17653185 | No |
| 1867 | 1589 | 1589.0 | 47.76 | 47.8 | Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. | L Bravo | Nutr Rev | 1998 | 9838798 | No |
| 1868 | 1589 | 1589.0 | 34.19 | 34.2 | Mechanisms of bone metastasis. | G David Roodman | N Engl J Med | 2004 | 15084698 | No |
| 1869 | 1589 | 1589.0 | 35.79 | 35.8 | Thiazolidinediones. | Hannele Yki-Järvinen | N Engl J Med | 2004 | 15356308 | No |
| 1870 | 1589 | 1589.0 | 51.93 | 51.9 | Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. | Virginia A Moyer | Ann Intern Med | 2012 | 22801674 | No |
| 1871 | 4766 | 1588.7 | 115.42 | 38.5 | Two-photon laser scanning fluorescence microscopy. | W Denk, J H Strickler, W W Webb | Science | 1990 | 2321027 | Yes |
| 1872 | 3177 | 1588.5 | 140.06 | 70.0 | MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. | Rajesha Rupaimoole, Frank J Slack | Nat Rev Drug Discov | 2017 | 28209991 | No |
| 1873 | 1588 | 1588.0 | 110.61 | 110.6 | Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. | C S Neer | J Bone Joint Surg Am | 1972 | 5054450 | Yes |
| 1874 | 3174 | 1587.0 | 118.27 | 59.1 | Universal chemical assay for the detection and determination of siderophores. | B Schwyn, J B Neilands | Anal Biochem | 1987 | 2952030 | Yes |
| 1875 | 1587 | 1587.0 | 0.0 | 0.0 | Discharge patterns and functional organization of mammalian retina. | S W Kuffler | J Neurophysiol | 1953 | 13035466 | Yes |
| 1876 | 1587 | 1587.0 | 0.0 | 0.0 | Cerebral vascular accidents in patients over the age of 60. II. Prognosis. | J Rankin | Scott Med J | 1957 | 13432835 | Yes |
| 1877 | 1586 | 1586.0 | 29.84 | 29.8 | Immunosuppressive networks in the tumour environment and their therapeutic relevance. | Weiping Zou | Nat Rev Cancer | 2005 | 15776005 | No |
| 1878 | 3171 | 1585.5 | 91.16 | 45.6 | Oxidative stress, glutamate, and neurodegenerative disorders. | J T Coyle, P Puttfarcken | Science | 1993 | 7901908 | No |
| 1879 | 1584 | 1584.0 | 49.5 | 49.5 | Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. | W H Oldendorf | Am J Physiol | 1971 | 5124307 | Yes |
| 1880 | 3168 | 1584.0 | 93.63 | 46.8 | Quality control and preprocessing of metagenomic datasets. | Robert Schmieder, Robert Edwards | Bioinformatics | 2011 | 21278185 | Yes |
| 1881 | 1583 | 1583.0 | 52.36 | 52.4 | Which elements are excited in electrical stimulation of mammalian central nervous system: a review. | J B Ranck | Brain Res | 1975 | 1102064 | No |
| 1882 | 3166 | 1583.0 | 98.74 | 49.4 | Palladium-catalyzed ligand-directed C-H functionalization reactions. | Thomas W Lyons, Melanie S Sanford | Chem Rev | 2010 | 20078038 | No |
| 1883 | 4748 | 1582.7 | 122.45 | 40.8 | Optimization by simulated annealing. | S Kirkpatrick, C D Gelatt, M P Vecchi | Science | 1983 | 17813860 | Yes |
| 1884 | 3165 | 1582.5 | 70.33 | 35.2 | The human plasma proteome: history, character, and diagnostic prospects. | N Leigh Anderson, Norman G Anderson | Mol Cell Proteomics | 2002 | 12488461 | No |
| 1885 | 1582 | 1582.0 | 46.92 | 46.9 | Dithiothreitol, A New Protective Reagent For Sh Groups. | W W Cleland | Biochemistry | 1964 | 14192894 | Yes |
| 1886 | 1582 | 1582.0 | 37.34 | 37.3 | The biology of incretin hormones. | Daniel J Drucker | Cell Metab | 2006 | 16517403 | No |
| 1887 | 3163 | 1581.5 | 96.87 | 48.4 | Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. | D S Bredt, S H Snyder | Proc Natl Acad Sci U S A | 1990 | 1689048 | Yes |
| 1888 | 1581 | 1581.0 | 62.28 | 62.3 | α-band oscillations, attention, and controlled access to stored information. | Wolfgang Klimesch | Trends Cogn Sci | 2012 | 23141428 | No |
| 1889 | 3160 | 1580.0 | 130.56 | 65.3 | Sex differences in immune responses. | Sabra L Klein, Katie L Flanagan | Nat Rev Immunol | 2016 | 27546235 | No |
| 1890 | 6315 | 1578.8 | 154.6 | 38.6 | Most mammalian mRNAs are conserved targets of microRNAs. | Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel | Genome Res | 2009 | 18955434 | Yes |
| 1891 | 1578 | 1578.0 | 29.27 | 29.3 | How cells read TGF-beta signals. | J Massagué | Nat Rev Mol Cell Biol | 2000 | 11252892 | No |
| 1892 | 1578 | 1578.0 | 29.8 | 29.8 | Protein degradation and protection against misfolded or damaged proteins. | Alfred L Goldberg | Nature | 2003 | 14685250 | No |
| 1893 | 3156 | 1578.0 | 91.12 | 45.6 | Extended-connectivity fingerprints. | David Rogers, Mathew Hahn | J Chem Inf Model | 2010 | 20426451 | Yes |
| 1894 | 4732 | 1577.3 | 105.68 | 35.2 | Click Chemistry: Diverse Chemical Function from a Few Good Reactions. | Hartmuth C. Kolb, M G Finn, K. Barry Sharpless | Angew Chem Int Ed Engl | 2001 | 11433435 | Yes |
| 1895 | 1577 | 1577.0 | 42.77 | 42.8 | The complete general secretory pathway in gram-negative bacteria. | A P Pugsley | Microbiol Rev | 1993 | 8096622 | No |
| 1896 | 1577 | 1577.0 | 33.51 | 33.5 | From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. | W A Catterall | Neuron | 2000 | 10798388 | No |
| 1897 | 1577 | 1577.0 | 35.95 | 36.0 | Neurotrophin-regulated signalling pathways. | Louis F Reichardt | Philos Trans R Soc Lond B Biol Sci | 2006 | 16939974 | No |
| 1898 | 1576 | 1576.0 | 35.34 | 35.3 | The proto-oncogene Bcl-2 and its role in regulating apoptosis. | G Kroemer | Nat Med | 1997 | 9176486 | No |
| 1899 | 3152 | 1576.0 | 57.71 | 28.9 | The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. | Michael H Glickman, Aaron Ciechanover | Physiol Rev | 2002 | 11917093 | No |
| 1900 | 3152 | 1576.0 | 67.32 | 33.7 | Complex networks orchestrate epithelial-mesenchymal transitions. | Jean Paul Thiery, Jonathan P Sleeman | Nat Rev Mol Cell Biol | 2006 | 16493418 | No |
| 1901 | 1575 | 1575.0 | 52.67 | 52.7 | Biology of interleukin 1. | C A Dinarello | FASEB J | 1988 | 3277884 | No |
| 1902 | 3150 | 1575.0 | 185.35 | 92.7 | Rating systems in the evaluation of knee ligament injuries. | Y Tegner, J Lysholm | Clin Orthop Relat Res | 1985 | 4028566 | Yes |
| 1903 | 1575 | 1575.0 | 48.69 | 48.7 | The law of attrition. | Gunther Eysenbach | J Med Internet Res | 2005 | 15829473 | Yes |
| 1904 | 1575 | 1575.0 | 33.43 | 33.4 | Tumor metastasis: mechanistic insights and clinical challenges. | Patricia S Steeg | Nat Med | 2006 | 16892035 | No |
| 1905 | 3150 | 1575.0 | 95.42 | 47.7 | LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. | Roman A Laskowski, Mark B Swindells | J Chem Inf Model | 2011 | 21919503 | Yes |
| 1906 | 3149 | 1574.5 | 67.94 | 34.0 | Microtubules as a target for anticancer drugs. | Mary Ann Jordan, Leslie Wilson | Nat Rev Cancer | 2004 | 15057285 | No |
| 1907 | 1574 | 1574.0 | 37.62 | 37.6 | HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. | J M Coffin | Science | 1995 | 7824947 | Yes |
| 1908 | 1573 | 1573.0 | 65.1 | 65.1 | Regulation of noradrenaline release by presynaptic receptor systems. | K Starke | Rev Physiol Biochem Pharmacol | 1977 | 14389 | No |
| 1909 | 1573 | 1573.0 | 26.01 | 26.0 | Neuronal specification in the spinal cord: inductive signals and transcriptional codes. | T M Jessell | Nat Rev Genet | 2000 | 11262869 | No |
| 1910 | 1573 | 1573.0 | 29.58 | 29.6 | Intrinsically unstructured proteins. | Peter Tompa | Trends Biochem Sci | 2002 | 12368089 | No |
| 1911 | 3146 | 1573.0 | 88.91 | 44.5 | Accessories to the crime: functions of cells recruited to the tumor microenvironment. | Douglas Hanahan, Lisa M Coussens | Cancer Cell | 2012 | 22439926 | No |
| 1912 | 3144 | 1572.0 | 108.99 | 54.5 | The M1 and M2 paradigm of macrophage activation: time for reassessment. | Fernando O Martinez, Siamon Gordon | F1000Prime Rep | 2014 | 24669294 | No |
| 1913 | 3142 | 1571.0 | 101.04 | 50.5 | The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. | R Doll, R Peto | J Natl Cancer Inst | 1981 | 7017215 | No |
| 1914 | 1571 | 1571.0 | 41.64 | 41.6 | Molecular bases of the acute coronary syndromes. | P Libby | Circulation | 1995 | 7758192 | No |
| 1915 | 1571 | 1571.0 | 31.19 | 31.2 | The Buccaneer software for automated model building. 1. Tracing protein chains. | Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2006 | 16929101 | Yes |
| 1916 | 3142 | 1571.0 | 66.76 | 33.4 | Cancer metastasis: building a framework. | Gaorav P Gupta, Joan Massagué | Cell | 2006 | 17110329 | No |
| 1917 | 4713 | 1571.0 | 235.01 | 78.3 | Radiomics: Images Are More than Pictures, They Are Data. | Robert J Gillies, Paul E Kinahan, Hedvig Hricak | Radiology | 2016 | 26579733 | Yes |
| 1918 | 3141 | 1570.5 | 74.12 | 37.1 | Malignant gliomas in adults. | Patrick Y Wen, Santosh Kesari | N Engl J Med | 2008 | 18669428 | No |
| 1919 | 3140 | 1570.0 | 66.27 | 33.1 | Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. | C B Lozzio, B B Lozzio | Blood | 1975 | 163658 | Yes |
| 1920 | 1570 | 1570.0 | 44.81 | 44.8 | Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. | S Hakomori | Annu Rev Biochem | 1981 | 7023369 | No |
| 1921 | 14125 | 1569.4 | 434.85 | 48.3 | The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. | D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C Dunbar | J Clin Psychiatry | 1998 | 9881538 | No |
| 1922 | 1569 | 1569.0 | 27.79 | 27.8 | Selforganization of matter and the evolution of biological macromolecules. | M Eigen | Naturwissenschaften | 1971 | 4942363 | No |
| 1923 | 3138 | 1569.0 | 75.93 | 38.0 | Steatohepatitis: a tale of two "hits"? | C P Day, O F James | Gastroenterology | 1998 | 9547102 | No |
| 1924 | 3138 | 1569.0 | 60.46 | 30.2 | Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. | O Tetsu, F McCormick | Nature | 1999 | 10201372 | Yes |
| 1925 | 1569 | 1569.0 | 0.0 | 0.0 | A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. | B C Hummel | Can J Biochem Physiol | 1959 | 14405350 | Yes |
| 1926 | 4706 | 1568.7 | 169.61 | 56.5 | Complex heatmaps reveal patterns and correlations in multidimensional genomic data. | Zuguang Gu, Roland Eils, Matthias Schlesner | Bioinformatics | 2016 | 27207943 | Yes |
| 1927 | 4703 | 1567.7 | 93.08 | 31.0 | Efficient selection for high-expression transfectants with a novel eukaryotic vector. | H Niwa, K Yamamura, J Miyazaki | Gene | 1991 | 1660837 | Yes |
| 1928 | 1567 | 1567.0 | 59.23 | 59.2 | Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. | P Holzer | Neuroscience | 1988 | 3288903 | No |
| 1929 | 3134 | 1567.0 | 81.73 | 40.9 | The gut microbiota shapes intestinal immune responses during health and disease. | June L Round, Sarkis K Mazmanian | Nat Rev Immunol | 2009 | 19343057 | No |
| 1930 | 4700 | 1566.7 | 87.59 | 29.2 | Notch signaling: cell fate control and signal integration in development. | S Artavanis-Tsakonas, M D Rand, R J Lake | Science | 1999 | 10221902 | No |
| 1931 | 3131 | 1565.5 | 78.93 | 39.5 | Dali server: conservation mapping in 3D. | Liisa Holm, Päivi Rosenström | Nucleic Acids Res | 2010 | 20457744 | Yes |
| 1932 | 1564 | 1564.0 | 42.15 | 42.1 | Stress and depression. | Constance Hammen | Annu Rev Clin Psychol | 2005 | 17716090 | No |
| 1933 | 1564 | 1564.0 | 33.61 | 33.6 | The tumor microenvironment and its role in promoting tumor growth. | T L Whiteside | Oncogene | 2008 | 18836471 | No |
| 1934 | 3127 | 1563.5 | 106.67 | 53.3 | Diabetes and cardiovascular disease. The Framingham study. | W B Kannel, D L McGee | JAMA | 1979 | 430798 | Yes |
| 1935 | 3126 | 1563.0 | 80.73 | 40.4 | Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. | Gerard Talavera, Jose Castresana | Syst Biol | 2007 | 17654362 | Yes |
| 1936 | 1562 | 1562.0 | 61.33 | 61.3 | A structured interview guide for the Hamilton Depression Rating Scale. | J B Williams | Arch Gen Psychiatry | 1988 | 3395203 | Yes |
| 1937 | 1561 | 1561.0 | 36.37 | 36.4 | The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. | H Maeda | Adv Enzyme Regul | 2001 | 11384745 | No |
| 1938 | 1560 | 1560.0 | 42.92 | 42.9 | Bioactive microbial metabolites. | János Bérdy | J Antibiot (Tokyo) | 2005 | 15813176 | No |
| 1939 | 1560 | 1560.0 | 0.0 | 0.0 | The estimation of phosphorus. | R J Allen | Biochem J | 1940 | 16747230 | Yes |
| 1940 | 3118 | 1559.0 | 66.43 | 33.2 | Self-assembly at all scales. | George M Whitesides, Bartosz Grzybowski | Science | 2002 | 11923529 | Yes |
| 1941 | 3118 | 1559.0 | 150.68 | 75.3 | A simple practice guide for dose conversion between animals and human. | Anroop B Nair, Shery Jacob | J Basic Clin Pharm | 2016 | 27057123 | No |
| 1942 | 15587 | 1558.7 | 370.91 | 37.1 | Multilineage potential of adult human mesenchymal stem cells. | M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R Marshak | Science | 1999 | 10102814 | Yes |
| 1943 | 1558 | 1558.0 | 45.49 | 45.5 | The glomerular permeability determined by dextran clearance using Sephadex gel filtration. | C E Mogensen | Scand J Clin Lab Invest | 1968 | 5637478 | Yes |
| 1944 | 1558 | 1558.0 | 31.24 | 31.2 | The ubiquitin-proteasome proteolytic pathway. | A Ciechanover | Cell | 1994 | 7923371 | No |
| 1945 | 1558 | 1558.0 | 38.29 | 38.3 | Use and misuse of the receiver operating characteristic curve in risk prediction. | Nancy R Cook | Circulation | 2007 | 17309939 | Yes |
| 1946 | 9346 | 1557.7 | 274.43 | 45.7 | The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. | Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gøtzsche, Jan P Vandenbroucke | Lancet | 2007 | 18064739 | Yes |
| 1947 | 1557 | 1557.0 | 58.87 | 58.9 | Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement. | Virginia A Moyer | Ann Intern Med | 2014 | 24378917 | No |
| 1948 | 1556 | 1556.0 | 48.34 | 48.3 | Evidence for a central component of post-injury pain hypersensitivity. | C J Woolf | Nature | 1983 | 6656869 | Yes |
| 1949 | 3112 | 1556.0 | 94.64 | 47.3 | Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. | Riccardo Lencioni, Josep M Llovet | Semin Liver Dis | 2010 | 20175033 | No |
| 1950 | 1555 | 1555.0 | 77.3 | 77.3 | Bias in analytic research. | D L Sackett | J Chronic Dis | 1979 | 447779 | Yes |
| 1951 | 1555 | 1555.0 | 35.05 | 35.0 | Pathogenesis of group A streptococcal infections. | M W Cunningham | Clin Microbiol Rev | 2000 | 10885988 | No |
| 1952 | 1555 | 1555.0 | 36.21 | 36.2 | Upconversion and anti-Stokes processes with f and d ions in solids. | François Auzel | Chem Rev | 2004 | 14719973 | Yes |
| 1953 | 3108 | 1554.0 | 58.39 | 29.2 | Mutations affecting segment number and polarity in Drosophila. | C Nüsslein-Volhard, E Wieschaus | Nature | 1980 | 6776413 | Yes |
| 1954 | 1554 | 1554.0 | 28.67 | 28.7 | Vienna RNA secondary structure server. | Ivo L Hofacker | Nucleic Acids Res | 2003 | 12824340 | Yes |
| 1955 | 4660 | 1553.3 | 103.49 | 34.5 | Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. | M A Frohman, M K Dush, G R Martin | Proc Natl Acad Sci U S A | 1988 | 2461560 | Yes |
| 1956 | 1553 | 1553.0 | 43.72 | 43.7 | Surface plasmon resonance sensors for detection of chemical and biological species. | Jirí Homola | Chem Rev | 2008 | 18229953 | No |
| 1957 | 3105 | 1552.5 | 205.84 | 102.9 | ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R. | Emmanuel Paradis, Klaus Schliep | Bioinformatics | 2019 | 30016406 | Yes |
| 1958 | 3103 | 1551.5 | 68.88 | 34.4 | The DNA damage response: making it safe to play with knives. | Alberto Ciccia, Stephen J Elledge | Mol Cell | 2010 | 20965415 | No |
| 1959 | 17065 | 1551.4 | 445.56 | 40.5 | The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. | Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristo | Genome Res | 2010 | 20644199 | Yes |
| 1960 | 4653 | 1551.0 | 155.79 | 51.9 | Phylogenetic identification and in situ detection of individual microbial cells without cultivation. | R I Amann, W Ludwig, K H Schleifer | Microbiol Rev | 1995 | 7535888 | No |
| 1961 | 1550 | 1550.0 | 51.68 | 51.7 | A Social Neuroscience Perspective on Adolescent Risk-Taking. | Laurence Steinberg | Dev Rev | 2008 | 18509515 | Yes |
| 1962 | 3099 | 1549.5 | 61.72 | 30.9 | Toll-like receptor control of the adaptive immune responses. | Akiko Iwasaki, Ruslan Medzhitov | Nat Immunol | 2004 | 15454922 | No |
| 1963 | 3098 | 1549.0 | 71.49 | 35.7 | A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. | L Buck, R Axel | Cell | 1991 | 1840504 | Yes |
| 1964 | 1549 | 1549.0 | 59.69 | 59.7 | AliView: a fast and lightweight alignment viewer and editor for large datasets. | Anders Larsson | Bioinformatics | 2014 | 25095880 | Yes |
| 1965 | 1548 | 1548.0 | 48.75 | 48.8 | The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. | G R Buettner | Arch Biochem Biophys | 1993 | 8434935 | No |
| 1966 | 4643 | 1547.7 | 88.5 | 29.5 | A highly sensitive adenylate cyclase assay. | Y Salomon, C Londos, M Rodbell | Anal Biochem | 1974 | 4827395 | Yes |
| 1967 | 1547 | 1547.0 | 43.76 | 43.8 | Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. | A E Pegg | Cancer Res | 1988 | 3123052 | No |
| 1968 | 3094 | 1547.0 | 39.95 | 20.0 | Computed circular dichroism spectra for the evaluation of protein conformation. | N Greenfield, G D Fasman | Biochemistry | 1969 | 5346390 | Yes |
| 1969 | 1547 | 1547.0 | 32.21 | 32.2 | Drug discovery: a historical perspective. | J Drews | Science | 2000 | 10720314 | No |
| 1970 | 3094 | 1547.0 | 104.17 | 52.1 | Van der Waals heterostructures. | A K Geim, I V Grigorieva | Nature | 2013 | 23887427 | Yes |
| 1971 | 7734 | 1546.8 | 152.69 | 30.5 | Prospective identification of tumorigenic breast cancer cells. | Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F Clarke | Proc Natl Acad Sci U S A | 2003 | 12629218 | Yes |
| 1972 | 3093 | 1546.5 | 56.58 | 28.3 | Cellular motility driven by assembly and disassembly of actin filaments. | Thomas D Pollard, Gary G Borisy | Cell | 2003 | 12600310 | No |
| 1973 | 1546 | 1546.0 | 42.13 | 42.1 | Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. | A Fabiato | Am J Physiol | 1983 | 6346892 | No |
| 1974 | 3092 | 1546.0 | 120.53 | 60.3 | Assessment of eating disorders: interview or self-report questionnaire? | C G Fairburn, S J Beglin | Int J Eat Disord | 1994 | 7866415 | Yes |
| 1975 | 1546 | 1546.0 | 67.37 | 67.4 | Derivation and validation of a short-form oral health impact profile. | G D Slade | Community Dent Oral Epidemiol | 1997 | 9332805 | Yes |
| 1976 | 1546 | 1546.0 | 51.26 | 51.3 | Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. | K Anders Ericsson | Acad Med | 2004 | 15383395 | No |
| 1977 | 3092 | 1546.0 | 76.84 | 38.4 | Obesity. | David W Haslam, W Philip T James | Lancet | 2005 | 16198769 | No |
| 1978 | 3090 | 1545.0 | 79.36 | 39.7 | Empirical threshold values for quantitative trait mapping. | G A Churchill, R W Doerge | Genetics | 1994 | 7851788 | Yes |
| 1979 | 1545 | 1545.0 | 0.0 | 0.0 | Nutrition needs of mammalian cells in tissue culture. | H Eagle | Science | 1955 | 13255879 | Yes |
| 1980 | 1545 | 1545.0 | 36.83 | 36.8 | Myeloperoxidase: friend and foe. | Seymour J Klebanoff | J Leukoc Biol | 2005 | 15689384 | No |
| 1981 | 4634 | 1544.7 | 127.38 | 42.5 | Cell death: the significance of apoptosis. | A H Wyllie, J F Kerr, A R Currie | Int Rev Cytol | 1980 | 7014501 | No |
| 1982 | 3088 | 1544.0 | 61.95 | 31.0 | The Bcl2 family: regulators of the cellular life-or-death switch. | Suzanne Cory, Jerry M Adams | Nat Rev Cancer | 2002 | 12209154 | No |
| 1983 | 3086 | 1543.0 | 183.54 | 91.8 | A scaled version of the General Health Questionnaire. | D P Goldberg, V F Hillier | Psychol Med | 1979 | 424481 | Yes |
| 1984 | 1542 | 1542.0 | 29.98 | 30.0 | Macromolecular crowding: obvious but underappreciated. | R J Ellis | Trends Biochem Sci | 2001 | 11590012 | No |
| 1985 | 1542 | 1542.0 | 43.55 | 43.5 | Glycobiology: Toward Understanding the Function of Sugars. | Raymond A. Dwek | Chem Rev | 1996 | 11848770 | Yes |
| 1986 | 4625 | 1541.7 | 119.16 | 39.7 | How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. | R M Sapolsky, L M Romero, A U Munck | Endocr Rev | 2000 | 10696570 | No |
| 1987 | 1541 | 1541.0 | 59.77 | 59.8 | MorphoJ: an integrated software package for geometric morphometrics. | Christian Peter Klingenberg | Mol Ecol Resour | 2011 | 21429143 | Yes |
| 1988 | 3081 | 1540.5 | 63.4 | 31.7 | Coordination of circadian timing in mammals. | Steven M Reppert, David R Weaver | Nature | 2002 | 12198538 | No |
| 1989 | 1540 | 1540.0 | 43.71 | 43.7 | Mitochondria and cancer. | Douglas C Wallace | Nat Rev Cancer | 2012 | 23001348 | No |
| 1990 | 4619 | 1539.7 | 130.44 | 43.5 | The fusiform face area: a module in human extrastriate cortex specialized for face perception. | N Kanwisher, J McDermott, M M Chun | J Neurosci | 1997 | 9151747 | Yes |
| 1991 | 1539 | 1539.0 | 54.45 | 54.5 | Biological applications of ionophores. | B C Pressman | Annu Rev Biochem | 1976 | 786156 | No |
| 1992 | 1539 | 1539.0 | 30.77 | 30.8 | RNA silencing in plants. | David Baulcombe | Nature | 2004 | 15372043 | No |
| 1993 | 1539 | 1539.0 | 32.93 | 32.9 | Critical period plasticity in local cortical circuits. | Takao K Hensch | Nat Rev Neurosci | 2005 | 16261181 | No |
| 1994 | 1539 | 1539.0 | 64.93 | 64.9 | Periodontitis: from microbial immune subversion to systemic inflammation. | George Hajishengallis | Nat Rev Immunol | 2015 | 25534621 | No |
| 1995 | 3075 | 1537.5 | 73.43 | 36.7 | Decision curve analysis: a novel method for evaluating prediction models. | Andrew J Vickers, Elena B Elkin | Med Decis Making | 2006 | 17099194 | Yes |
| 1996 | 3074 | 1537.0 | 71.39 | 35.7 | New Giemsa method for the differential staining of sister chromatids. | P Perry, S Wolff | Nature | 1974 | 4138930 | Yes |
| 1997 | 4611 | 1537.0 | 117.62 | 39.2 | Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. | B Fischl, M I Sereno, A M Dale | Neuroimage | 1999 | 9931269 | Yes |
| 1998 | 3074 | 1537.0 | 0.0 | 0.0 | A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. | G Schmidt, S J Thannhauser | J Biol Chem | 1945 | 21005717 | Yes |
| 1999 | 1536 | 1536.0 | 42.67 | 42.7 | Emotion regulation: affective, cognitive, and social consequences. | James J Gross | Psychophysiology | 2002 | 12212647 | No |
| 2000 | 3072 | 1536.0 | 21.52 | 10.8 | Junctional complexes in various epithelia. | M G Farquhar, G E Palade | J Cell Biol | 1963 | 13944428 | Yes |
| 2001 | 1536 | 1536.0 | 41.73 | 41.7 | n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. | Philip C Calder | Am J Clin Nutr | 2006 | 16841861 | No |
| 2002 | 1536 | 1536.0 | 45.1 | 45.1 | Signal transduction by reactive oxygen species. | Toren Finkel | J Cell Biol | 2011 | 21746850 | No |
| 2003 | 3071 | 1535.5 | 62.46 | 31.2 | Development by self-digestion: molecular mechanisms and biological functions of autophagy. | Beth Levine, Daniel J Klionsky | Dev Cell | 2004 | 15068787 | No |
| 2004 | 6141 | 1535.2 | 119.35 | 29.8 | A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. | B M Bolstad, R A Irizarry, M Astrand, T P Speed | Bioinformatics | 2003 | 12538238 | Yes |
| 2005 | 3070 | 1535.0 | 74.89 | 37.4 | Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. | Felix Krueger, Simon R Andrews | Bioinformatics | 2011 | 21493656 | Yes |
| 2006 | 1534 | 1534.0 | 30.12 | 30.1 | E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. | J R Nevins | Science | 1992 | 1411535 | Yes |
| 2007 | 9202 | 1533.7 | 282.45 | 47.1 | TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. | Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg | Genome Biol | 2013 | 23618408 | Yes |
| 2008 | 3067 | 1533.5 | 87.87 | 43.9 | What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. | J Zhang, K F Yu | JAMA | 1998 | 9832001 | Yes |
| 2009 | 4600 | 1533.3 | 99.17 | 33.1 | Osteoclast differentiation and activation. | William J Boyle, W Scott Simonet, David L Lacey | Nature | 2003 | 12748652 | No |
| 2010 | 3066 | 1533.0 | 66.48 | 33.2 | Cellular senescence: when bad things happen to good cells. | Judith Campisi, Fabrizio d'Adda di Fagagna | Nat Rev Mol Cell Biol | 2007 | 17667954 | No |
| 2011 | 1532 | 1532.0 | 45.78 | 45.8 | Recent advances in the biochemistry of polyamines in eukaryotes. | A E Pegg | Biochem J | 1986 | 3087344 | No |
| 2012 | 3063 | 1531.5 | 67.23 | 33.6 | Cell migration: a physically integrated molecular process. | D A Lauffenburger, A F Horwitz | Cell | 1996 | 8608589 | No |
| 2013 | 3063 | 1531.5 | 92.39 | 46.2 | CTFFIND4: Fast and accurate defocus estimation from electron micrographs. | Alexis Rohou, Nikolaus Grigorieff | J Struct Biol | 2015 | 26278980 | Yes |
| 2014 | 1531 | 1531.0 | 48.55 | 48.5 | Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. | C A Barnes | J Comp Physiol Psychol | 1979 | 221551 | Yes |
| 2015 | 1531 | 1531.0 | 56.09 | 56.1 | Statistical analysis of enzyme kinetic data. | W W Cleland | Methods Enzymol | 1979 | 502857 | Yes |
| 2016 | 1531 | 1531.0 | 37.91 | 37.9 | Type I diabetes mellitus. A chronic autoimmune disease. | G S Eisenbarth | N Engl J Med | 1986 | 3517648 | No |
| 2017 | 4592 | 1530.7 | 111.63 | 37.2 | Membrane lipids: where they are and how they behave. | Gerrit van Meer, Dennis R Voelker, Gerald W Feigenson | Nat Rev Mol Cell Biol | 2008 | 18216768 | No |
| 2018 | 9183 | 1530.5 | 215.16 | 35.9 | Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. | Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O Lötvall | Nat Cell Biol | 2007 | 17486113 | Yes |
| 2019 | 1530 | 1530.0 | 67.06 | 67.1 | Human agency in social cognitive theory. | A Bandura | Am Psychol | 1989 | 2782727 | Yes |
| 2020 | 3058 | 1529.0 | 80.29 | 40.1 | Materials for electrochemical capacitors. | Patrice Simon, Yury Gogotsi | Nat Mater | 2008 | 18956000 | Yes |
| 2021 | 3057 | 1528.5 | 78.96 | 39.5 | Lipid rafts as a membrane-organizing principle. | Daniel Lingwood, Kai Simons | Science | 2010 | 20044567 | No |
| 2022 | 1528 | 1528.0 | 33.74 | 33.7 | Molecular themes in oncogenesis. | J M Bishop | Cell | 1991 | 1988146 | No |
| 2023 | 1528 | 1528.0 | 41.26 | 41.3 | Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. | L A Liotta | Cancer Res | 1986 | 2998604 | No |
| 2024 | 1528 | 1528.0 | 22.23 | 22.2 | An enzymic method for the trace iodination of immunoglobulins and other proteins. | J J Marchalonis | Biochem J | 1969 | 4185494 | Yes |
| 2025 | 1528 | 1528.0 | 46.03 | 46.0 | Domino Reactions in Organic Synthesis. | Lutz F. Tietze | Chem Rev | 1996 | 11848746 | Yes |
| 2026 | 1528 | 1528.0 | 33.78 | 33.8 | Ordered porous materials for emerging applications. | Mark E Davis | Nature | 2002 | 12075343 | No |
| 2027 | 1528 | 1528.0 | 31.37 | 31.4 | Antigen-Antibody Crossed Electrophoresis. | C B Laurell | Anal Biochem | 1965 | 14302464 | Yes |
| 2028 | 1527 | 1527.0 | 34.6 | 34.6 | Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). | K M Fox | Lancet | 2003 | 13678872 | Yes |
| 2029 | 1526 | 1526.0 | 34.65 | 34.6 | Dopamine (3-hydroxytyramine) and brain function. | O Hornykiewicz | Pharmacol Rev | 1966 | 5328389 | No |
| 2030 | 3052 | 1526.0 | 67.48 | 33.7 | NF-kappaB: a key role in inflammatory diseases. | P P Tak, G S Firestein | J Clin Invest | 2001 | 11134171 | No |
| 2031 | 6103 | 1525.8 | 2576.9 | 644.2 | Cancer statistics, 2023. | Rebecca L Siegel, Kimberly D Miller, Nikita Sandeep Wagle, Ahmedin Jemal | CA Cancer J Clin | 2023 | 36633525 | Yes |
| 2032 | 1525 | 1525.0 | 42.36 | 42.4 | Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. | Y Ben-Ari | Neuroscience | 1985 | 2859548 | No |
| 2033 | 3049 | 1524.5 | 70.88 | 35.4 | Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. | F Q Schafer, G R Buettner | Free Radic Biol Med | 2001 | 11368918 | No |
| 2034 | 1524 | 1524.0 | 38.78 | 38.8 | Early signals in the mitogenic response. | E Rozengurt | Science | 1986 | 3018928 | No |
| 2035 | 1523 | 1523.0 | 18.69 | 18.7 | A soluble protein characteristic of the nervous system. | B W Moore | Biochem Biophys Res Commun | 1965 | 4953930 | Yes |
| 2036 | 1523 | 1523.0 | 50.23 | 50.2 | Some observations upon a new inhibitor of monoamine oxidase in brain tissue. | J P Johnston | Biochem Pharmacol | 1968 | 5659776 | Yes |
| 2037 | 1523 | 1523.0 | 47.33 | 47.3 | The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. | J L Cummings | Neurology | 1997 | 9153155 | No |
| 2038 | 1522 | 1522.0 | 60.32 | 60.3 | The global burden of IBD: from 2015 to 2025. | Gilaad G Kaplan | Nat Rev Gastroenterol Hepatol | 2015 | 26323879 | No |
| 2039 | 4565 | 1521.7 | 51.66 | 17.2 | Improved method for the determination of blood glutathione. | E Beutler, O Duron, B M Kelly | J Lab Clin Med | 1963 | 13967893 | Yes |
| 2040 | 1521 | 1521.0 | 49.84 | 49.8 | The measurement of psychological androgyny. | S L Bem | J Consult Clin Psychol | 1974 | 4823550 | Yes |
| 2041 | 1521 | 1521.0 | 51.42 | 51.4 | Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. | S Katz | J Am Geriatr Soc | 1983 | 6418786 | No |
| 2042 | 3041 | 1520.5 | 114.32 | 57.2 | Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. | Susan Whitfield-Gabrieli, Alfonso Nieto-Castanon | Brain Connect | 2012 | 22642651 | Yes |
| 2043 | 1520 | 1520.0 | 45.57 | 45.6 | Calcium release from the sarcoplasmic reticulum. | M Endo | Physiol Rev | 1977 | 13441 | Yes |
| 2044 | 1520 | 1520.0 | 55.63 | 55.6 | Atherogenesis: a postprandial phenomenon. | D B Zilversmit | Circulation | 1979 | 222498 | Yes |
| 2045 | 1520 | 1520.0 | 48.64 | 48.6 | Inflammation in atherosclerosis. | Peter Libby | Arterioscler Thromb Vasc Biol | 2012 | 22895665 | No |
| 2046 | 3039 | 1519.5 | 82.94 | 41.5 | Genome regulation by long noncoding RNAs. | John L Rinn, Howard Y Chang | Annu Rev Biochem | 2012 | 22663078 | No |
| 2047 | 4557 | 1519.0 | 96.13 | 32.0 | The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. | S K Hanks, A M Quinn, T Hunter | Science | 1988 | 3291115 | No |
| 2048 | 4553 | 1517.7 | 157.83 | 52.6 | CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. | Teresa C Horan, Mary Andrus, Margaret A Dudeck | Am J Infect Control | 2008 | 18538699 | No |
| 2049 | 1517 | 1517.0 | 90.76 | 90.8 | Stimulated acoustic emissions from within the human auditory system. | D T Kemp | J Acoust Soc Am | 1978 | 744838 | Yes |
| 2050 | 1517 | 1517.0 | 31.66 | 31.7 | Cancer epigenomics: DNA methylomes and histone-modification maps. | Manel Esteller | Nat Rev Genet | 2007 | 17339880 | No |
| 2051 | 1516 | 1516.0 | 38.17 | 38.2 | Interoception: the sense of the physiological condition of the body. | A D Craig | Curr Opin Neurobiol | 2003 | 12965300 | No |
| 2052 | 1516 | 1516.0 | 65.29 | 65.3 | Machine Learning in Medicine. | Rahul C Deo | Circulation | 2015 | 26572668 | No |
| 2053 | 1515 | 1515.0 | 37.98 | 38.0 | Trophic factors and neuronal survival. | Y A Barde | Neuron | 1989 | 2697237 | No |
| 2054 | 1515 | 1515.0 | 27.92 | 27.9 | Aggresomes, inclusion bodies and protein aggregation. | R R Kopito | Trends Cell Biol | 2000 | 11121744 | No |
| 2055 | 1515 | 1515.0 | 32.95 | 33.0 | Far-field optical nanoscopy. | Stefan W Hell | Science | 2007 | 17525330 | No |
| 2056 | 1514 | 1514.0 | 40.21 | 40.2 | Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. | H S Penefsky | J Biol Chem | 1977 | 16006 | Yes |
| 2057 | 1514 | 1514.0 | 50.23 | 50.2 | Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. | H J Gundersen | J Microsc | 1986 | 3761363 | Yes |
| 2058 | 4541 | 1513.7 | 222.28 | 74.1 | Shedding light on the cell biology of extracellular vesicles. | Guillaume van Niel, Gisela D'Angelo, Graça Raposo | Nat Rev Mol Cell Biol | 2018 | 29339798 | No |
| 2059 | 3027 | 1513.5 | 88.04 | 44.0 | Mediation in experimental and nonexperimental studies: new procedures and recommendations. | Patrick E Shrout, Niall Bolger | Psychol Methods | 2002 | 12530702 | Yes |
| 2060 | 1513 | 1513.0 | 48.48 | 48.5 | SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. | B P O'Connor | Behav Res Methods Instrum Comput | 2000 | 11029811 | Yes |
| 2061 | 1513 | 1513.0 | 49.25 | 49.2 | The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. | Poul Erik Petersen | Community Dent Oral Epidemiol | 2003 | 15015736 | Yes |
| 2062 | 4536 | 1512.0 | 175.3 | 58.4 | Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. | Jack Bowden, George Davey Smith, Stephen Burgess | Int J Epidemiol | 2015 | 26050253 | Yes |
| 2063 | 1511 | 1511.0 | 42.56 | 42.6 | The Hospital Anxiety And Depression Scale. | R Philip Snaith | Health Qual Life Outcomes | 2003 | 12914662 | Yes |
| 2064 | 4532 | 1510.7 | 120.45 | 40.1 | I-TASSER: a unified platform for automated protein structure and function prediction. | Ambrish Roy, Alper Kucukural, Yang Zhang | Nat Protoc | 2010 | 20360767 | Yes |
| 2065 | 1510 | 1510.0 | 48.18 | 48.2 | Health consequences of obesity in youth: childhood predictors of adult disease. | W H Dietz | Pediatrics | 1998 | 12224658 | No |
| 2066 | 3016 | 1508.0 | 76.67 | 38.3 | Abdominal obesity and metabolic syndrome. | Jean-Pierre Després, Isabelle Lemieux | Nature | 2006 | 17167477 | No |
| 2067 | 3016 | 1508.0 | 62.04 | 31.0 | Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. | Joshua E Elias, Steven P Gygi | Nat Methods | 2007 | 17327847 | Yes |
| 2068 | 1508 | 1508.0 | 37.16 | 37.2 | Reconciling the chemistry and biology of reactive oxygen species. | Christine C Winterbourn | Nat Chem Biol | 2008 | 18421291 | No |
| 2069 | 1507 | 1507.0 | 33.54 | 33.5 | The molecular logic of endocannabinoid signalling. | Daniele Piomelli | Nat Rev Neurosci | 2003 | 14595399 | No |
| 2070 | 1506 | 1506.0 | 43.84 | 43.8 | The fetal and infant origins of adult disease. | D J Barker | BMJ | 1990 | 2252919 | No |
| 2071 | 3011 | 1505.5 | 58.95 | 29.5 | Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. | P J Mitchell, R Tjian | Science | 1989 | 2667136 | No |
| 2072 | 3009 | 1504.5 | 101.61 | 50.8 | Thermodynamics of protein association reactions: forces contributing to stability. | P D Ross, S Subramanian | Biochemistry | 1981 | 7248271 | Yes |
| 2073 | 19558 | 1504.5 | 506.11 | 38.9 | Clustal W and Clustal X version 2.0. | M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G Higgins | Bioinformatics | 2007 | 17846036 | Yes |
| 2074 | 1503 | 1503.0 | 32.88 | 32.9 | Hyaluronan: from extracellular glue to pericellular cue. | Bryan P Toole | Nat Rev Cancer | 2004 | 15229478 | No |
| 2075 | 1503 | 1503.0 | 31.63 | 31.6 | Topoisomerase I inhibitors: camptothecins and beyond. | Yves Pommier | Nat Rev Cancer | 2006 | 16990856 | No |
| 2076 | 3005 | 1502.5 | 87.84 | 43.9 | The cortical organization of speech processing. | Gregory Hickok, David Poeppel | Nat Rev Neurosci | 2007 | 17431404 | No |
| 2077 | 4507 | 1502.3 | 161.18 | 53.7 | Hydroperoxide metabolism in mammalian organs. | B Chance, H Sies, A Boveris | Physiol Rev | 1979 | 37532 | Yes |
| 2078 | 1501 | 1501.0 | 40.76 | 40.8 | Rheumatoid arthritis. Pathophysiology and implications for therapy. | E D Harris | N Engl J Med | 1990 | 2271017 | No |
| 2079 | 3001 | 1500.5 | 0.0 | 0.0 | Mutations of Bacteria from Virus Sensitivity to Virus Resistance. | S E Luria, M Delbrück | Genetics | 1943 | 17247100 | Yes |
| 2080 | 1500 | 1500.0 | 43.77 | 43.8 | Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. | E N Bergman | Physiol Rev | 1990 | 2181501 | No |
| 2081 | 3000 | 1500.0 | 60.09 | 30.0 | Chemokines: a new classification system and their role in immunity. | A Zlotnik, O Yoshie | Immunity | 2000 | 10714678 | No |
| 2082 | 1500 | 1500.0 | 25.41 | 25.4 | Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. | K Fuxe | Acta Physiol Scand Suppl | 1965 | 14319769 | Yes |
| 2083 | 3000 | 1500.0 | 88.59 | 44.3 | Porosity of 3D biomaterial scaffolds and osteogenesis. | Vassilis Karageorgiou, David Kaplan | Biomaterials | 2005 | 15860204 | No |
| 2084 | 2999 | 1499.5 | 66.36 | 33.2 | How matrix metalloproteinases regulate cell behavior. | M D Sternlicht, Z Werb | Annu Rev Cell Dev Biol | 2001 | 11687497 | No |
| 2085 | 1499 | 1499.0 | 26.4 | 26.4 | R factor transfer in Rhizobium leguminosarum. | J E Beringer | J Gen Microbiol | 1974 | 4612098 | Yes |
| 2086 | 1499 | 1499.0 | 42.47 | 42.5 | Isolated removal of hypothalamic or other brain nuclei of the rat. | M Palkovits | Brain Res | 1973 | 4747772 | Yes |
| 2087 | 1498 | 1498.0 | 52.16 | 52.2 | Lyme disease. | A C Steere | N Engl J Med | 1989 | 2668764 | No |
| 2088 | 1498 | 1498.0 | 35.58 | 35.6 | Neuronal synchrony: a versatile code for the definition of relations? | W Singer | Neuron | 1999 | 10677026 | No |
| 2089 | 1498 | 1498.0 | 0.0 | 0.0 | A new readability yardstick. | R Flesch | J Appl Psychol | 1948 | 18867058 | Yes |
| 2090 | 1497 | 1497.0 | 33.65 | 33.6 | Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. | M B Luskin | Neuron | 1993 | 8338665 | Yes |
| 2091 | 1497 | 1497.0 | 0.0 | 0.0 | The colorimetric determination of phosphorus. | E J King | Biochem J | 1932 | 16744823 | Yes |
| 2092 | 1496 | 1496.0 | 47.61 | 47.6 | Stability of proteins: small globular proteins. | P L Privalov | Adv Protein Chem | 1979 | 44431 | No |
| 2093 | 2992 | 1496.0 | 0.0 | 0.0 | Lactic dehydrogenase activity in blood. | F Wroblewski, J S Ladue | Proc Soc Exp Biol Med | 1955 | 13273400 | Yes |
| 2094 | 1496 | 1496.0 | 36.54 | 36.5 | Fast and robust fixed-point algorithms for independent component analysis. | A Hyvärinen | IEEE Trans Neural Netw | 1999 | 18252563 | Yes |
| 2095 | 10468 | 1495.4 | 222.68 | 31.8 | Embryonic stem cell lines derived from human blastocysts. | J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M Jones | Science | 1998 | 9804556 | Yes |
| 2096 | 2989 | 1494.5 | 114.94 | 57.5 | Cisplatin in cancer therapy: molecular mechanisms of action. | Shaloam Dasari, Paul Bernard Tchounwou | Eur J Pharmacol | 2014 | 25058905 | No |
| 2097 | 1494 | 1494.0 | 70.82 | 70.8 | Chronic illness as biographical disruption. | M Bury | Sociol Health Illn | 1982 | 10260456 | Yes |
| 2098 | 1494 | 1494.0 | 32.5 | 32.5 | The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. | S E Kahn | Diabetologia | 2003 | 12637977 | No |
| 2099 | 1493 | 1493.0 | 55.05 | 55.0 | Cardiac valve surgery--the "French correction". | A Carpentier | J Thorac Cardiovasc Surg | 1983 | 6887954 | Yes |
| 2100 | 1493 | 1493.0 | 26.13 | 26.1 | Histone acetylation and transcriptional regulatory mechanisms. | K Struhl | Genes Dev | 1998 | 9499396 | No |
| 2101 | 1493 | 1493.0 | 36.97 | 37.0 | An economic method for the fluorescent labeling of PCR fragments. | M Schuelke | Nat Biotechnol | 2000 | 10657137 | Yes |
| 2102 | 1492 | 1492.0 | 33.09 | 33.1 | Tumor suppressor genes. | R A Weinberg | Science | 1991 | 1659741 | No |
| 2103 | 1492 | 1492.0 | 46.52 | 46.5 | Polycystic ovary syndrome. | S Franks | N Engl J Med | 1995 | 7651477 | No |
| 2104 | 4476 | 1492.0 | 129.49 | 43.2 | Validation of the Insomnia Severity Index as an outcome measure for insomnia research. | C H. Bastien, A Vallières, C M. Morin | Sleep Med | 2001 | 11438246 | Yes |
| 2105 | 4475 | 1491.7 | 111.69 | 37.2 | The metabolic syndrome. | Robert H Eckel, Scott M Grundy, Paul Z Zimmet | Lancet | 2005 | 15836891 | No |
| 2106 | 5965 | 1491.2 | 130.04 | 32.5 | Probability-based protein identification by searching sequence databases using mass spectrometry data. | D N Perkins, D J Pappin, D M Creasy, J S Cottrell | Electrophoresis | 1999 | 10612281 | Yes |
| 2107 | 1491 | 1491.0 | 59.0 | 59.0 | An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. | J Kabat-Zinn | Gen Hosp Psychiatry | 1982 | 7042457 | Yes |
| 2108 | 2980 | 1490.0 | 56.92 | 28.5 | Missing pieces in the NF-kappaB puzzle. | Sankar Ghosh, Michael Karin | Cell | 2002 | 11983155 | No |
| 2109 | 1489 | 1489.0 | 43.13 | 43.1 | Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. | M D Maines | FASEB J | 1988 | 3290025 | No |
| 2110 | 2977 | 1488.5 | 63.94 | 32.0 | Escaping free-energy minima. | Alessandro Laio, Michele Parrinello | Proc Natl Acad Sci U S A | 2002 | 12271136 | Yes |
| 2111 | 1488 | 1488.0 | 60.11 | 60.1 | Working memory: theories, models, and controversies. | Alan Baddeley | Annu Rev Psychol | 2012 | 21961947 | No |
| 2112 | 13382 | 1486.9 | 622.84 | 69.2 | Cancer statistics in China, 2015. | Wanqing Chen, Rongshou Zheng, Peter D Baade, Siwei Zhang, Hongmei Zeng, Freddie Bray, Ahmedin Jemal, Xue Qin Yu, Jie He | CA Cancer J Clin | 2016 | 26808342 | Yes |
| 2113 | 1486 | 1486.0 | 33.95 | 34.0 | Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. | J C Unkeless | J Exp Med | 1979 | 90108 | Yes |
| 2114 | 1486 | 1486.0 | 39.12 | 39.1 | The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. | A S Fauci | Science | 1988 | 3277274 | No |
| 2115 | 1486 | 1486.0 | 76.83 | 76.8 | The determinants of parenting: a process model. | J Belsky | Child Dev | 1984 | 6705636 | Yes |
| 2116 | 1486 | 1486.0 | 36.84 | 36.8 | Wound healing and its impairment in the diabetic foot. | Vincent Falanga | Lancet | 2005 | 16291068 | No |
| 2117 | 2971 | 1485.5 | 86.44 | 43.2 | Software survey: VOSviewer, a computer program for bibliometric mapping. | Nees Jan van Eck, Ludo Waltman | Scientometrics | 2010 | 20585380 | Yes |
| 2118 | 1485 | 1485.0 | 31.65 | 31.6 | Autophagy: from phenomenology to molecular understanding in less than a decade. | Daniel J Klionsky | Nat Rev Mol Cell Biol | 2007 | 17712358 | No |
| 2119 | 2969 | 1484.5 | 193.14 | 96.6 | OrthoFinder: phylogenetic orthology inference for comparative genomics. | David M Emms, Steven Kelly | Genome Biol | 2019 | 31727128 | Yes |
| 2120 | 4453 | 1484.3 | 93.59 | 31.2 | TOR signaling in growth and metabolism. | Stephan Wullschleger, Robbie Loewith, Michael N Hall | Cell | 2006 | 16469695 | No |
| 2121 | 1483 | 1483.0 | 33.2 | 33.2 | Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. | C Taswell | J Immunol | 1981 | 7009746 | Yes |
| 2122 | 2965 | 1482.5 | 87.35 | 43.7 | From best evidence to best practice: effective implementation of change in patients' care. | Richard Grol, Jeremy Grimshaw | Lancet | 2003 | 14568747 | No |
| 2123 | 1482 | 1482.0 | 27.35 | 27.4 | Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. | S Avrameas | Immunochemistry | 1969 | 4975324 | Yes |
| 2124 | 1482 | 1482.0 | 7.91 | 7.9 | Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. | R W Sperry | Proc Natl Acad Sci U S A | 1963 | 14077501 | Yes |
| 2125 | 2964 | 1482.0 | 98.91 | 49.5 | How useful is SBF in predicting in vivo bone bioactivity? | Tadashi Kokubo, Hiroaki Takadama | Biomaterials | 2006 | 16448693 | No |
| 2126 | 1481 | 1481.0 | 18.45 | 18.4 | The mechanism of muscular contraction. | H E Huxley | Science | 1969 | 4181952 | No |
| 2127 | 2962 | 1481.0 | 88.84 | 44.4 | Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. | P J Basser, C Pierpaoli | J Magn Reson B | 1996 | 8661285 | Yes |
| 2128 | 1480 | 1480.0 | 36.51 | 36.5 | Defective repair replication of DNA in xeroderma pigmentosum. | J E Cleaver | Nature | 1968 | 5655953 | Yes |
| 2129 | 1480 | 1480.0 | 19.72 | 19.7 | Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. | J W Olney | Science | 1969 | 5778021 | Yes |
| 2130 | 4440 | 1480.0 | 45.79 | 15.3 | The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. | J T Dodge, C Mitchell, D J Hanahan | Arch Biochem Biophys | 1963 | 14028302 | Yes |
| 2131 | 1480 | 1480.0 | 33.86 | 33.9 | Nonaqueous liquid electrolytes for lithium-based rechargeable batteries. | Kang Xu | Chem Rev | 2004 | 15669157 | Yes |
| 2132 | 2960 | 1480.0 | 74.55 | 37.3 | Molecular replacement with MOLREP. | Alexei Vagin, Alexei Teplyakov | Acta Crystallogr D Biol Crystallogr | 2010 | 20057045 | Yes |
| 2133 | 1479 | 1479.0 | 40.26 | 40.3 | Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. | J A Beavo | Physiol Rev | 1995 | 7480160 | No |
| 2134 | 1479 | 1479.0 | 39.48 | 39.5 | Redox signaling: nitrosylation and related target interactions of nitric oxide. | J S Stamler | Cell | 1994 | 7923362 | No |
| 2135 | 8874 | 1479.0 | 259.09 | 43.2 | Cancer statistics, 2009. | Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J Thun | CA Cancer J Clin | 2009 | 19474385 | Yes |
| 2136 | 4435 | 1478.3 | 78.92 | 26.3 | Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. | C A Winter, E A Risley, G W Nuss | Proc Soc Exp Biol Med | 1962 | 14001233 | Yes |
| 2137 | 5913 | 1478.2 | 247.25 | 61.8 | A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. | M A Markwell, S M Haas, L L Bieber, N E Tolbert | Anal Biochem | 1978 | 98070 | Yes |
| 2138 | 1478 | 1478.0 | 46.14 | 46.1 | Superoxide dismutases. | I Fridovich | Annu Rev Biochem | 1975 | 1094908 | No |
| 2139 | 1478 | 1478.0 | 30.69 | 30.7 | Ionic blockage of sodium channels in nerve. | A M Woodhull | J Gen Physiol | 1973 | 4541078 | Yes |
| 2140 | 2956 | 1478.0 | 107.12 | 53.6 | A new initiative on precision medicine. | Francis S Collins, Harold Varmus | N Engl J Med | 2015 | 25635347 | Yes |
| 2141 | 4433 | 1477.7 | 134.81 | 44.9 | Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. | S van der Linden, H A Valkenburg, A Cats | Arthritis Rheum | 1984 | 6231933 | Yes |
| 2142 | 1476 | 1476.0 | 33.77 | 33.8 | The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. | M Takeichi | Development | 1988 | 3048970 | No |
| 2143 | 1476 | 1476.0 | 45.25 | 45.2 | Equipoise and the ethics of clinical research. | B Freedman | N Engl J Med | 1987 | 3600702 | Yes |
| 2144 | 1475 | 1475.0 | 29.28 | 29.3 | The Relation Of Recombination To Mutational Advance. | H J Muller | Mutat Res | 1964 | 14195748 | Yes |
| 2145 | 1475 | 1475.0 | 43.07 | 43.1 | Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. | M Robin DiMatteo | Med Care | 2004 | 15076819 | Yes |
| 2146 | 1475 | 1475.0 | 0.0 | 0.0 | The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. | O V Batson | Ann Surg | 1940 | 17857618 | Yes |
| 2147 | 1473 | 1473.0 | 36.61 | 36.6 | The 'effective number of codons' used in a gene. | F Wright | Gene | 1990 | 2110097 | Yes |
| 2148 | 1473 | 1473.0 | 19.62 | 19.6 | Codon--anticodon pairing: the wobble hypothesis. | F H Crick | J Mol Biol | 1966 | 5969078 | Yes |
| 2149 | 1473 | 1473.0 | 10.68 | 10.7 | Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. | H E Huxley | J Mol Biol | 1963 | 14064165 | Yes |
| 2150 | 1472 | 1472.0 | 36.38 | 36.4 | Microbial ecology of the gastrointestinal tract. | D C Savage | Annu Rev Microbiol | 1977 | 334036 | No |
| 2151 | 2944 | 1472.0 | 76.43 | 38.2 | The expanding universe of T-cell subsets: Th1, Th2 and more. | T R Mosmann, S Sad | Immunol Today | 1996 | 8820272 | No |
| 2152 | 1472 | 1472.0 | 34.19 | 34.2 | Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. | P C Nowell | Cancer Res | 1960 | 14427849 | Yes |
| 2153 | 2943 | 1471.5 | 79.91 | 40.0 | A general method for isolation of high molecular weight DNA from eukaryotes. | N Blin, D W Stafford | Nucleic Acids Res | 1976 | 987581 | Yes |
| 2154 | 1471 | 1471.0 | 38.29 | 38.3 | The world health report 2002 - reducing risks, promoting healthy life. | J J Guilbert | Educ Health (Abingdon) | 2003 | 14741909 | Yes |
| 2155 | 13235 | 1470.6 | 407.46 | 45.3 | The 1982 revised criteria for the classification of systemic lupus erythematosus. | E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J Winchester | Arthritis Rheum | 1982 | 7138600 | Yes |
| 2156 | 1470 | 1470.0 | 52.16 | 52.2 | Phase retrieval algorithms: a comparison. | J R Fienup | Appl Opt | 1982 | 20396114 | Yes |
| 2157 | 4408 | 1469.3 | 86.05 | 28.7 | The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. | Fabio Martinon, Kimberly Burns, Jürg Tschopp | Mol Cell | 2002 | 12191486 | Yes |
| 2158 | 1469 | 1469.0 | 0.0 | 0.0 | Modality and topographic properties of single neurons of cat's somatic sensory cortex. | V B Mountcastle | J Neurophysiol | 1957 | 13439410 | Yes |
| 2159 | 1468 | 1468.0 | 37.2 | 37.2 | Hemispheric asymmetry reduction in older adults: the HAROLD model. | Roberto Cabeza | Psychol Aging | 2002 | 11931290 | No |
| 2160 | 1468 | 1468.0 | 40.1 | 40.1 | Leishmaniasis: current situation and new perspectives. | P Desjeux | Comp Immunol Microbiol Infect Dis | 2004 | 15225981 | No |
| 2161 | 2935 | 1467.5 | 91.59 | 45.8 | Functional architecture of basal ganglia circuits: neural substrates of parallel processing. | G E Alexander, M D Crutcher | Trends Neurosci | 1990 | 1695401 | No |
| 2162 | 2935 | 1467.5 | 41.09 | 20.5 | The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. | E G Gray, V P Whittaker | J Anat | 1962 | 13901297 | Yes |
| 2163 | 2935 | 1467.5 | 77.91 | 39.0 | Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. | B R Celli, W MacNee | Eur Respir J | 2004 | 15219010 | No |
| 2164 | 4401 | 1467.0 | 95.45 | 31.8 | Telomeres shorten during ageing of human fibroblasts. | C B Harley, A B Futcher, C W Greider | Nature | 1990 | 2342578 | Yes |
| 2165 | 1467 | 1467.0 | 94.65 | 94.7 | The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. | F Denis | Spine (Phila Pa 1976) | 1983 | 6670016 | Yes |
| 2166 | 2931 | 1465.5 | 74.07 | 37.0 | A globally coherent fingerprint of climate change impacts across natural systems. | Camille Parmesan, Gary Yohe | Nature | 2003 | 12511946 | Yes |
| 2167 | 1465 | 1465.0 | 33.51 | 33.5 | Simple methods for "staining with lead" at high pH in electron microscopy. | M J Karnovsky | J Biophys Biochem Cytol | 1961 | 14454024 | Yes |
| 2168 | 1465 | 1465.0 | 45.44 | 45.4 | Amino acids: metabolism, functions, and nutrition. | Guoyao Wu | Amino Acids | 2009 | 19301095 | No |
| 2169 | 2929 | 1464.5 | 119.5 | 59.8 | 3D bioprinting of tissues and organs. | Sean V Murphy, Anthony Atala | Nat Biotechnol | 2014 | 25093879 | Yes |
| 2170 | 1464 | 1464.0 | 31.81 | 31.8 | Mitochondria: dynamic organelles in disease, aging, and development. | David C Chan | Cell | 2006 | 16814712 | No |
| 2171 | 1464 | 1464.0 | 31.78 | 31.8 | DNA damage, aging, and cancer. | Jan H J Hoeijmakers | N Engl J Med | 2009 | 19812404 | No |
| 2172 | 1463 | 1463.0 | 57.2 | 57.2 | Reliability and factor analysis of the Epworth Sleepiness Scale. | M W Johns | Sleep | 1992 | 1519015 | Yes |
| 2173 | 1463 | 1463.0 | 33.82 | 33.8 | PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. | B M Spiegelman | Diabetes | 1998 | 9568680 | No |
| 2174 | 1463 | 1463.0 | 38.16 | 38.2 | Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. | Michael F Holick | Am J Clin Nutr | 2004 | 15585788 | No |
| 2175 | 1463 | 1463.0 | 41.77 | 41.8 | Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. | Charles A Dinarello | Blood | 2011 | 21304099 | No |
| 2176 | 4387 | 1462.3 | 136.95 | 45.6 | AChE-stained horizontal sections of the rat brain in stereotaxic coordinates. | G Paxinos, C R Watson, P C Emson | J Neurosci Methods | 1980 | 6110810 | Yes |
| 2177 | 2924 | 1462.0 | 67.72 | 33.9 | The MAPK signaling cascade. | R Seger, E G Krebs | FASEB J | 1995 | 7601337 | No |
| 2178 | 1462 | 1462.0 | 40.95 | 41.0 | Treatment of infections associated with surgical implants. | Rabih O Darouiche | N Engl J Med | 2004 | 15070792 | No |
| 2179 | 1462 | 1462.0 | 0.0 | 0.0 | Notes on continuous stochastic phenomena. | P A P Moran | Biometrika | 1950 | 15420245 | Yes |
| 2180 | 2922 | 1461.0 | 98.49 | 49.2 | Peptidoglycan types of bacterial cell walls and their taxonomic implications. | K H Schleifer, O Kandler | Bacteriol Rev | 1972 | 4568761 | No |
| 2181 | 2922 | 1461.0 | 57.9 | 28.9 | Intrinsically unstructured proteins and their functions. | H Jane Dyson, Peter E Wright | Nat Rev Mol Cell Biol | 2005 | 15738986 | No |
| 2182 | 1461 | 1461.0 | 0.0 | 0.0 | The free amino groups of insulin. | F Sanger | Biochem J | 1945 | 16747948 | Yes |
| 2183 | 2922 | 1461.0 | 73.55 | 36.8 | Morris water maze: procedures for assessing spatial and related forms of learning and memory. | Charles V Vorhees, Michael T Williams | Nat Protoc | 2006 | 17406317 | Yes |
| 2184 | 1461 | 1461.0 | 34.91 | 34.9 | Origin, biogenesis, and activity of plant microRNAs. | Olivier Voinnet | Cell | 2009 | 19239888 | No |
| 2185 | 2920 | 1460.0 | 93.53 | 46.8 | Synchronization of Plasmodium falciparum erythrocytic stages in culture. | C Lambros, J P Vanderberg | J Parasitol | 1979 | 383936 | Yes |
| 2186 | 1460 | 1460.0 | 51.41 | 51.4 | The prevalence of 'alexithymic' characteristics in psychosomatic patients. | P E Sifneos | Psychother Psychosom | 1973 | 4770536 | Yes |
| 2187 | 1460 | 1460.0 | 0.0 | 0.0 | Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. | I E Bush | Biochem J | 1952 | 14915960 | Yes |
| 2188 | 5836 | 1459.0 | 212.78 | 53.2 | FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. | Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs Schoffelen | Comput Intell Neurosci | 2011 | 21253357 | Yes |
| 2189 | 1459 | 1459.0 | 64.67 | 64.7 | Mechanisms linking social ties and support to physical and mental health. | Peggy A Thoits | J Health Soc Behav | 2011 | 21673143 | No |
| 2190 | 1458 | 1458.0 | 34.18 | 34.2 | Oxidative stress in Parkinson's disease. | Peter Jenner | Ann Neurol | 2003 | 12666096 | No |
| 2191 | 1457 | 1457.0 | 34.35 | 34.4 | Binary Agrobacterium vectors for plant transformation. | M Bevan | Nucleic Acids Res | 1984 | 6095209 | Yes |
| 2192 | 1457 | 1457.0 | 29.74 | 29.7 | Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. | S S Ferguson | Pharmacol Rev | 2001 | 11171937 | No |
| 2193 | 1457 | 1457.0 | 43.81 | 43.8 | The functional gastrointestinal disorders and the Rome III process. | Douglas A Drossman | Gastroenterology | 2006 | 16678553 | No |
| 2194 | 1457 | 1457.0 | 32.89 | 32.9 | Cell signaling. H2O2, a necessary evil for cell signaling. | Sue Goo Rhee | Science | 2006 | 16809515 | Yes |
| 2195 | 1457 | 1457.0 | 40.87 | 40.9 | BEDTools: The Swiss-Army Tool for Genome Feature Analysis. | Aaron R Quinlan | Curr Protoc Bioinformatics | 2014 | 25199790 | Yes |
| 2196 | 5824 | 1456.0 | 147.62 | 36.9 | Microbial ecology: human gut microbes associated with obesity. | Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I Gordon | Nature | 2006 | 17183309 | Yes |
| 2197 | 11643 | 1455.4 | 289.32 | 36.2 | Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. | N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M Joliot | Neuroimage | 2002 | 11771995 | Yes |
| 2198 | 1455 | 1455.0 | 39.04 | 39.0 | A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. | J Engel | Epilepsia | 2001 | 11422340 | Yes |
| 2199 | 1455 | 1455.0 | 0.0 | 0.0 | A modified ninhydrin colorimetric analysis for amino acids. | H Rosen | Arch Biochem Biophys | 1957 | 13412116 | Yes |
| 2200 | 2909 | 1454.5 | 87.42 | 43.7 | An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. | O Johnell, J A Kanis | Osteoporos Int | 2006 | 16983459 | Yes |
| 2201 | 2908 | 1454.0 | 102.01 | 51.0 | Assay of proteins in the presence of interfering materials. | A Bensadoun, D Weinstein | Anal Biochem | 1976 | 1259145 | Yes |
| 2202 | 2908 | 1454.0 | 74.89 | 37.4 | Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. | I Issemann, S Green | Nature | 1990 | 2129546 | Yes |
| 2203 | 1454 | 1454.0 | 57.61 | 57.6 | Social phobia. | M R Liebowitz | Mod Probl Pharmacopsychiatry | 1987 | 2885745 | Yes |
| 2204 | 1454 | 1454.0 | 46.23 | 46.2 | A clinical method for assessing the ventilatory response to carbon dioxide. | D J Read | Australas Ann Med | 1967 | 6032026 | Yes |
| 2205 | 1454 | 1454.0 | 31.56 | 31.6 | Protein misfolding, evolution and disease. | C M Dobson | Trends Biochem Sci | 1999 | 10470028 | No |
| 2206 | 1454 | 1454.0 | 35.54 | 35.5 | The amygdala modulates the consolidation of memories of emotionally arousing experiences. | James L McGaugh | Annu Rev Neurosci | 2004 | 15217324 | No |
| 2207 | 5812 | 1453.0 | 158.22 | 39.6 | Image quality assessment: from error visibility to structural similarity. | Zhou Wang, Alan Conrad Bovik, Hamid Rahim Sheikh, Eero P Simoncelli | IEEE Trans Image Process | 2004 | 15376593 | Yes |
| 2208 | 2904 | 1452.0 | 0.0 | 0.0 | Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. | D H Clarke, J Casals | Am J Trop Med Hyg | 1958 | 13571577 | Yes |
| 2209 | 4354 | 1451.3 | 100.92 | 33.6 | Long non-coding RNAs: insights into functions. | Tim R Mercer, Marcel E Dinger, John S Mattick | Nat Rev Genet | 2009 | 19188922 | No |
| 2210 | 2902 | 1451.0 | 60.3 | 30.1 | The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. | M S Brown, J L Goldstein | Cell | 1997 | 9150132 | No |
| 2211 | 1450 | 1450.0 | 28.84 | 28.8 | The organization of proteins in the human red blood cell membrane. A review. | T L Steck | J Cell Biol | 1974 | 4600883 | No |
| 2212 | 2900 | 1450.0 | 57.57 | 28.8 | Short-term synaptic plasticity. | Robert S Zucker, Wade G Regehr | Annu Rev Physiol | 2002 | 11826273 | No |
| 2213 | 1450 | 1450.0 | 0.0 | 0.0 | The generalisation of student's problems when several different population variances are involved. | B L Welch | Biometrika | 1947 | 20287819 | Yes |
| 2214 | 2899 | 1449.5 | 79.39 | 39.7 | A rapid boiling method for the preparation of bacterial plasmids. | D S Holmes, M Quigley | Anal Biochem | 1981 | 6269464 | Yes |
| 2215 | 4348 | 1449.3 | 92.65 | 30.9 | NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. | S Ghosh, M J May, E B Kopp | Annu Rev Immunol | 1998 | 9597130 | No |
| 2216 | 2898 | 1449.0 | 74.14 | 37.1 | 3' non-coding region sequences in eukaryotic messenger RNA. | N J Proudfoot, G G Brownlee | Nature | 1976 | 822353 | Yes |
| 2217 | 1449 | 1449.0 | 33.58 | 33.6 | Developmental cell death: morphological diversity and multiple mechanisms. | P G Clarke | Anat Embryol (Berl) | 1990 | 2186664 | No |
| 2218 | 1449 | 1449.0 | 94.72 | 94.7 | The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. | F C Ewald | Clin Orthop Relat Res | 1989 | 2805502 | Yes |
| 2219 | 1449 | 1449.0 | 40.64 | 40.6 | Breakthrough of the year 2013. Cancer immunotherapy. | Jennifer Couzin-Frankel | Science | 2013 | 24357284 | No |
| 2220 | 1448 | 1448.0 | 48.58 | 48.6 | Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. | G A McPherson | J Pharmacol Methods | 1985 | 3840547 | Yes |
| 2221 | 5790 | 1447.5 | 162.25 | 40.6 | The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. | L A Sternberger, P H Hardy, J J Cuculis, H G Meyer | J Histochem Cytochem | 1970 | 4192899 | Yes |
| 2222 | 1447 | 1447.0 | 35.47 | 35.5 | General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. | R A Houghten | Proc Natl Acad Sci U S A | 1985 | 2410914 | Yes |
| 2223 | 2894 | 1447.0 | 94.64 | 47.3 | The efficiency of systematic sampling in stereology and its prediction. | H J Gundersen, E B Jensen | J Microsc | 1987 | 3430576 | Yes |
| 2224 | 1447 | 1447.0 | 36.97 | 37.0 | The intraclass correlation coefficient as a measure of reliability. | J J Bartko | Psychol Rep | 1966 | 5942109 | Yes |
| 2225 | 2894 | 1447.0 | 66.03 | 33.0 | Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. | C Auffray, F Rougeon | Eur J Biochem | 1980 | 6772444 | Yes |
| 2226 | 1447 | 1447.0 | 36.18 | 36.2 | Stress and hippocampal plasticity. | B S McEwen | Annu Rev Neurosci | 1999 | 10202533 | No |
| 2227 | 2894 | 1447.0 | 62.16 | 31.1 | A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. | A H Anton, D F Sayre | J Pharmacol Exp Ther | 1962 | 14013351 | Yes |
| 2228 | 1447 | 1447.0 | 40.06 | 40.1 | Graphene transistors. | Frank Schwierz | Nat Nanotechnol | 2010 | 20512128 | Yes |
| 2229 | 1446 | 1446.0 | 30.3 | 30.3 | Neurotrophins as synaptic modulators. | M M Poo | Nat Rev Neurosci | 2001 | 11253356 | No |
| 2230 | 7229 | 1445.8 | 321.98 | 64.4 | BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs. | Felipe A Simão, Robert M Waterhouse, Panagiotis Ioannidis, Evgenia V Kriventseva, Evgeny M Zdobnov | Bioinformatics | 2015 | 26059717 | Yes |
| 2231 | 2890 | 1445.0 | 73.53 | 36.8 | Alternative activation of macrophages: mechanism and functions. | Siamon Gordon, Fernando O Martinez | Immunity | 2010 | 20510870 | No |
| 2232 | 1444 | 1444.0 | 49.94 | 49.9 | Colorimetric determination of phospholipids with ammonium ferrothiocyanate. | J C Stewart | Anal Biochem | 1980 | 6892980 | Yes |
| 2233 | 1443 | 1443.0 | 42.97 | 43.0 | The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. | Artemis P Simopoulos | Exp Biol Med (Maywood) | 2008 | 18408140 | No |
| 2234 | 2886 | 1443.0 | 0.0 | 0.0 | Brain stem reticular formation and activation of the EEG. | G Moruzzi, H W Magoun | Electroencephalogr Clin Neurophysiol | 1949 | 18421835 | Yes |
| 2235 | 2885 | 1442.5 | 78.37 | 39.2 | Angiogenesis. | J Folkman, Y Shing | J Biol Chem | 1992 | 1375931 | No |
| 2236 | 2885 | 1442.5 | 0.0 | 0.0 | Mutants of Escherichia coli requiring methionine or vitamin B12. | B D Davis, E S Mingioli | J Bacteriol | 1950 | 15436457 | Yes |
| 2237 | 2883 | 1441.5 | 85.84 | 42.9 | The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. | J D Hayes, D J Pulford | Crit Rev Biochem Mol Biol | 1995 | 8770536 | No |
| 2238 | 2883 | 1441.5 | 67.41 | 33.7 | Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. | H Cai, D G Harrison | Circ Res | 2000 | 11073878 | No |
| 2239 | 1441 | 1441.0 | 37.82 | 37.8 | Cell and environment interactions in tumor microregions: the multicell spheroid model. | R M Sutherland | Science | 1988 | 2451290 | Yes |
| 2240 | 1441 | 1441.0 | 42.15 | 42.1 | Human cardiovascular adjustments to exercise and thermal stress. | L B Rowell | Physiol Rev | 1974 | 4587247 | No |
| 2241 | 1441 | 1441.0 | 21.54 | 21.5 | Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. | K S McCully | Am J Pathol | 1969 | 5792556 | Yes |
| 2242 | 1441 | 1441.0 | 59.32 | 59.3 | Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation. | Karimollah Hajian-Tilaki | Caspian J Intern Med | 2013 | 24009950 | No |
| 2243 | 5762 | 1440.5 | 168.58 | 42.1 | Reversible middle cerebral artery occlusion without craniectomy in rats. | E Z Longa, P R Weinstein, S Carlson, R Cummins | Stroke | 1989 | 2643202 | Yes |
| 2244 | 1440 | 1440.0 | 48.25 | 48.2 | Gene flow and the geographic structure of natural populations. | M Slatkin | Science | 1987 | 3576198 | Yes |
| 2245 | 2880 | 1440.0 | 55.33 | 27.7 | Autophagy as a regulated pathway of cellular degradation. | D J Klionsky, S D Emr | Science | 2000 | 11099404 | No |
| 2246 | 4318 | 1439.3 | 87.02 | 29.0 | Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). | Michael J Rust, Mark Bates, Xiaowei Zhuang | Nat Methods | 2006 | 16896339 | Yes |
| 2247 | 1439 | 1439.0 | 37.13 | 37.1 | Capacitative calcium entry revisited. | J W Putney | Cell Calcium | 1990 | 1965707 | No |
| 2248 | 1439 | 1439.0 | 43.78 | 43.8 | Biological basis of the behavior of sick animals. | B L Hart | Neurosci Biobehav Rev | 1988 | 3050629 | No |
| 2249 | 1439 | 1439.0 | 42.67 | 42.7 | Strong localization of photons in certain disordered dielectric superlattices. | S John | Phys Rev Lett | 1987 | 10034761 | Yes |
| 2250 | 1439 | 1439.0 | 0.0 | 0.0 | Potential, Impedance, And Rectification In Membranes. | D E Goldman | J Gen Physiol | 1943 | 19873371 | Yes |
| 2251 | 1438 | 1438.0 | 0.0 | 0.0 | Starch gel electrophoresis in a discontinous system of buffers. | M D Poulik | Nature | 1957 | 13493570 | Yes |
| 2252 | 2875 | 1437.5 | 0.0 | 0.0 | Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. | H J Bloom, W W Richardson | Br J Cancer | 1957 | 13499785 | Yes |
| 2253 | 2874 | 1437.0 | 53.65 | 26.8 | T-cell antigen receptor genes and T-cell recognition. | M M Davis, P J Bjorkman | Nature | 1988 | 3043226 | No |
| 2254 | 1437 | 1437.0 | 33.86 | 33.9 | Proinflammatory cytokines. | C A Dinarello | Chest | 2000 | 10936147 | No |
| 2255 | 1437 | 1437.0 | 63.87 | 63.9 | Oxidative stress: a concept in redox biology and medicine. | Helmut Sies | Redox Biol | 2015 | 25588755 | No |
| 2256 | 1437 | 1437.0 | 50.02 | 50.0 | Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. | Russell Lande | Evolution | 1979 | 28568194 | Yes |
| 2257 | 1436 | 1436.0 | 36.59 | 36.6 | The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. | T Szkudelski | Physiol Res | 2001 | 11829314 | No |
| 2258 | 1436 | 1436.0 | 27.43 | 27.4 | The significance of responses of the genome to challenge. | B McClintock | Science | 1984 | 15739260 | No |
| 2259 | 1436 | 1436.0 | 53.84 | 53.8 | Diversity in tropical rain forests and coral reefs. | J H Connell | Science | 1978 | 17840770 | Yes |
| 2260 | 1435 | 1435.0 | 37.47 | 37.5 | The epidemiology of venous thromboembolism. | Richard H White | Circulation | 2003 | 12814979 | No |
| 2261 | 8609 | 1434.8 | 282.35 | 47.1 | Antioxidant activity applying an improved ABTS radical cation decolorization assay. | R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-Evans | Free Radic Biol Med | 1999 | 10381194 | Yes |
| 2262 | 2869 | 1434.5 | 101.6 | 50.8 | Role of the microbiota in immunity and inflammation. | Yasmine Belkaid, Timothy W Hand | Cell | 2014 | 24679531 | No |
| 2263 | 4300 | 1433.3 | 146.45 | 48.8 | Factor structure of the Barratt impulsiveness scale. | J H Patton, M S Stanford, E S Barratt | J Clin Psychol | 1995 | 8778124 | Yes |
| 2264 | 7160 | 1432.0 | 154.21 | 30.8 | Site-directed mutagenesis by overlap extension using the polymerase chain reaction. | S N Ho, H D Hunt, R M Horton, J K Pullen, L R Pease | Gene | 1989 | 2744487 | Yes |
| 2265 | 1432 | 1432.0 | 40.81 | 40.8 | Recent developments in isocyanide based multicomponent reactions in applied chemistry. | Alexander Dömling | Chem Rev | 2006 | 16402771 | No |
| 2266 | 2863 | 1431.5 | 98.07 | 49.0 | The framing of decisions and the psychology of choice. | A Tversky, D Kahneman | Science | 1981 | 7455683 | Yes |
| 2267 | 1431 | 1431.0 | 60.37 | 60.4 | The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. | E J Khantzian | Am J Psychiatry | 1985 | 3904487 | No |
| 2268 | 1431 | 1431.0 | 39.99 | 40.0 | Isolation and cultivation of Lyme disease spirochetes. | A G Barbour | Yale J Biol Med | 1984 | 6393604 | Yes |
| 2269 | 1429 | 1429.0 | 24.75 | 24.8 | The economics of ribosome biosynthesis in yeast. | J R Warner | Trends Biochem Sci | 1999 | 10542411 | No |
| 2270 | 1429 | 1429.0 | 39.47 | 39.5 | The debate over dopamine's role in reward: the case for incentive salience. | Kent C Berridge | Psychopharmacology (Berl) | 2007 | 17072591 | No |
| 2271 | 2857 | 1428.5 | 98.36 | 49.2 | Selective loss of central cholinergic neurons in Alzheimer's disease. | P Davies, A J Maloney | Lancet | 1976 | 63862 | Yes |
| 2272 | 2857 | 1428.5 | 70.33 | 35.2 | Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. | E S Lander, D Botstein | Genetics | 1989 | 2563713 | Yes |
| 2273 | 4285 | 1428.3 | 87.74 | 29.2 | Toll-like receptors. | Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira | Annu Rev Immunol | 2003 | 12524386 | No |
| 2274 | 5709 | 1427.2 | 257.42 | 64.4 | Prevalence of childhood and adult obesity in the United States, 2011-2012. | Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M Flegal | JAMA | 2014 | 24570244 | Yes |
| 2275 | 2854 | 1427.0 | 83.0 | 41.5 | Physiological time-series analysis using approximate entropy and sample entropy. | J S Richman, J R Moorman | Am J Physiol Heart Circ Physiol | 2000 | 10843903 | Yes |
| 2276 | 1427 | 1427.0 | 44.52 | 44.5 | The role of autophagy in neurodegenerative disease. | Ralph A Nixon | Nat Med | 2013 | 23921753 | No |
| 2277 | 4277 | 1425.7 | 121.59 | 40.5 | Dose translation from animal to human studies revisited. | Shannon Reagan-Shaw, Minakshi Nihal, Nihal Ahmad | FASEB J | 2008 | 17942826 | Yes |
| 2278 | 1425 | 1425.0 | 40.93 | 40.9 | The aging process. | D Harman | Proc Natl Acad Sci U S A | 1981 | 6947277 | Yes |
| 2279 | 2850 | 1425.0 | 82.18 | 41.1 | CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. | Mattias Jakobsson, Noah A Rosenberg | Bioinformatics | 2007 | 17485429 | Yes |
| 2280 | 1425 | 1425.0 | 34.81 | 34.8 | The cancer stem cell: premises, promises and challenges. | Hans Clevers | Nat Med | 2011 | 21386835 | No |
| 2281 | 1425 | 1425.0 | 65.05 | 65.0 | PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors. | Anthony L Spek | Acta Crystallogr C Struct Chem | 2015 | 25567569 | Yes |
| 2282 | 2849 | 1424.5 | 90.39 | 45.2 | Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. | Johan W S Vlaeyen, Steven J Linton | Pain | 2000 | 10781906 | No |
| 2283 | 1424 | 1424.0 | 43.3 | 43.3 | Mate selection-a selection for a handicap. | A Zahavi | J Theor Biol | 1975 | 1195756 | Yes |
| 2284 | 1424 | 1424.0 | 25.56 | 25.6 | The DNA methyltransferases of mammals. | T H Bestor | Hum Mol Genet | 2000 | 11005794 | No |
| 2285 | 1424 | 1424.0 | 35.8 | 35.8 | Diagnosis of osteoporosis and assessment of fracture risk. | John A Kanis | Lancet | 2002 | 12057569 | No |
| 2286 | 2848 | 1424.0 | 54.89 | 27.4 | Cancer genes and the pathways they control. | Bert Vogelstein, Kenneth W Kinzler | Nat Med | 2004 | 15286780 | No |
| 2287 | 2846 | 1423.0 | 54.92 | 27.5 | Wnt signalling in stem cells and cancer. | Tannishtha Reya, Hans Clevers | Nature | 2005 | 15829953 | No |
| 2288 | 1423 | 1423.0 | 44.13 | 44.1 | Formation of glasses from liquids and biopolymers. | C A Angell | Science | 1995 | 17770101 | Yes |
| 2289 | 2843 | 1421.5 | 86.07 | 43.0 | Unidentified curved bacilli on gastric epithelium in active chronic gastritis. | J R Warren, B Marshall | Lancet | 1983 | 6134060 | Yes |
| 2290 | 1421 | 1421.0 | 33.27 | 33.3 | Functions of ceramide in coordinating cellular responses to stress. | Y A Hannun | Science | 1996 | 8943189 | No |
| 2291 | 1421 | 1421.0 | 33.64 | 33.6 | The use of nanocrystals in biological detection. | Paul Alivisatos | Nat Biotechnol | 2004 | 14704706 | Yes |
| 2292 | 2841 | 1420.5 | 72.87 | 36.4 | EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. | Stefan Stoll, Arthur Schweiger | J Magn Reson | 2006 | 16188474 | Yes |
| 2293 | 4261 | 1420.3 | 107.46 | 35.8 | Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. | Robert D Schreiber, Lloyd J Old, Mark J Smyth | Science | 2011 | 21436444 | No |
| 2294 | 1420 | 1420.0 | 26.59 | 26.6 | Ubiquitin-dependent protein degradation. | M Hochstrasser | Annu Rev Genet | 1996 | 8982460 | No |
| 2295 | 8519 | 1419.8 | 217.85 | 36.3 | Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. | Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur Wheeler | N Engl J Med | 2000 | 10793162 | Yes |
| 2296 | 1419 | 1419.0 | 51.53 | 51.5 | Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. | M P Blaustein | Am J Physiol | 1977 | 324293 | No |
| 2297 | 1419 | 1419.0 | 37.64 | 37.6 | A note on robust variance estimation for cluster-correlated data. | R L Williams | Biometrics | 2000 | 10877330 | Yes |
| 2298 | 1419 | 1419.0 | 65.31 | 65.3 | A New Weighting System For Mean Surface Temperature Of The Human Body. | N L Ramanathan | J Appl Physiol | 1964 | 14173555 | Yes |
| 2299 | 1418 | 1418.0 | 39.45 | 39.5 | Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. | J Wyman | Adv Protein Chem | 1964 | 14268785 | No |
| 2300 | 2834 | 1417.0 | 79.22 | 39.6 | Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. | F D Lublin, S C Reingold | Neurology | 1996 | 8780061 | Yes |
| 2301 | 1417 | 1417.0 | 45.01 | 45.0 | Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. | J J Gross | J Pers Soc Psychol | 1998 | 9457784 | Yes |
| 2302 | 2833 | 1416.5 | 89.75 | 44.9 | The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. | W R Gibb, A J Lees | J Neurol Neurosurg Psychiatry | 1988 | 2841426 | No |
| 2303 | 2832 | 1416.0 | 83.29 | 41.6 | Intracellular pH. | A Roos, W F Boron | Physiol Rev | 1981 | 7012859 | No |
| 2304 | 4246 | 1415.3 | 139.76 | 46.6 | Vascular endothelial cells synthesize nitric oxide from L-arginine. | R M Palmer, D S Ashton, S Moncada | Nature | 1988 | 3131684 | Yes |
| 2305 | 2830 | 1415.0 | 88.65 | 44.3 | Performing the exact test of Hardy-Weinberg proportion for multiple alleles. | S W Guo, E A Thompson | Biometrics | 1992 | 1637966 | Yes |
| 2306 | 4245 | 1415.0 | 100.94 | 33.6 | Wnt/beta-catenin signaling: components, mechanisms, and diseases. | Bryan T MacDonald, Keiko Tamai, Xi He | Dev Cell | 2009 | 19619488 | No |
| 2307 | 4243 | 1414.3 | 94.01 | 31.3 | OrthoMCL: identification of ortholog groups for eukaryotic genomes. | Li Li, Christian J Stoeckert, David S Roos | Genome Res | 2003 | 12952885 | Yes |
| 2308 | 2827 | 1413.5 | 62.35 | 31.2 | The pathophysiology and treatment of sepsis. | Richard S Hotchkiss, Irene E Karl | N Engl J Med | 2003 | 12519925 | No |
| 2309 | 2826 | 1413.0 | 52.31 | 26.2 | Oncogenic kinase signalling. | P Blume-Jensen, T Hunter | Nature | 2001 | 11357143 | No |
| 2310 | 2824 | 1412.0 | 147.1 | 73.5 | Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. | L F Berkman, S L Syme | Am J Epidemiol | 1979 | 425958 | Yes |
| 2311 | 1412 | 1412.0 | 50.59 | 50.6 | Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. | T Florian Jaeger | J Mem Lang | 2008 | 19884961 | Yes |
| 2312 | 1411 | 1411.0 | 33.95 | 34.0 | Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. | S S Lehrer | Biochemistry | 1971 | 5119250 | Yes |
| 2313 | 1411 | 1411.0 | 35.59 | 35.6 | Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. | Y Shai | Biochim Biophys Acta | 1999 | 10590302 | No |
| 2314 | 1411 | 1411.0 | 34.94 | 34.9 | Mitochondrial fusion and fission in cell life and death. | Benedikt Westermann | Nat Rev Mol Cell Biol | 2010 | 21102612 | No |
| 2315 | 4232 | 1410.7 | 154.39 | 51.5 | Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. | C J Caspersen, K E Powell, G M Christenson | Public Health Rep | 1985 | 3920711 | Yes |
| 2316 | 4232 | 1410.7 | 147.77 | 49.3 | Structure-antioxidant activity relationships of flavonoids and phenolic acids. | C A Rice-Evans, N J Miller, G Paganga | Free Radic Biol Med | 1996 | 8743980 | Yes |
| 2317 | 1410 | 1410.0 | 45.84 | 45.8 | Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. | N Krieger | Am J Public Health | 1992 | 1566949 | Yes |
| 2318 | 1410 | 1410.0 | 50.86 | 50.9 | The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. | A Raine | Schizophr Bull | 1991 | 1805349 | Yes |
| 2319 | 1409 | 1409.0 | 36.47 | 36.5 | Genetic consequences of climatic oscillations in the Quaternary. | G M Hewitt | Philos Trans R Soc Lond B Biol Sci | 2004 | 15101575 | No |
| 2320 | 2812 | 1406.0 | 76.93 | 38.5 | Transforming growth factor beta in tissue fibrosis. | W A Border, N A Noble | N Engl J Med | 1994 | 7935686 | No |
| 2321 | 2811 | 1405.5 | 69.84 | 34.9 | Molecular beacons: probes that fluoresce upon hybridization. | S Tyagi, F R Kramer | Nat Biotechnol | 1996 | 9630890 | Yes |
| 2322 | 2811 | 1405.5 | 0.0 | 0.0 | The effect of sodium ions on the electrical activity of giant axon of the squid. | A L Hodgkin, B Katz | J Physiol | 1949 | 18128147 | Yes |
| 2323 | 2810 | 1405.0 | 81.36 | 40.7 | Empirical predictions of protein conformation. | P Y Chou, G D Fasman | Annu Rev Biochem | 1978 | 354496 | No |
| 2324 | 1404 | 1404.0 | 32.75 | 32.8 | Speculations on the functions of the major heat shock and glucose-regulated proteins. | H R Pelham | Cell | 1986 | 2944601 | Yes |
| 2325 | 2808 | 1404.0 | 71.0 | 35.5 | CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. | D G Higgins, P M Sharp | Gene | 1988 | 3243435 | Yes |
| 2326 | 1404 | 1404.0 | 26.18 | 26.2 | NK cell receptors. | L L Lanier | Annu Rev Immunol | 1998 | 9597134 | No |
| 2327 | 1404 | 1404.0 | 34.13 | 34.1 | Tobacco smoke carcinogens and lung cancer. | S S Hecht | J Natl Cancer Inst | 1999 | 10413421 | No |
| 2328 | 1403 | 1403.0 | 25.22 | 25.2 | Selection of successive tumour lines for metastasis. | I J Fidler | Nat New Biol | 1973 | 4512654 | Yes |
| 2329 | 1403 | 1403.0 | 62.89 | 62.9 | Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. | P de Leva | J Biomech | 1996 | 8872282 | Yes |
| 2330 | 2806 | 1403.0 | 0.0 | 0.0 | Virus interference. I. The interferon. | A Isaacs, J Lindenmann | Proc R Soc Lond B Biol Sci | 1957 | 13465720 | Yes |
| 2331 | 2805 | 1402.5 | 69.21 | 34.6 | Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. | M D Pierschbacher, E Ruoslahti | Nature | 1984 | 6325925 | Yes |
| 2332 | 1402 | 1402.0 | 33.34 | 33.3 | The basic science of gene therapy. | R C Mulligan | Science | 1993 | 8493530 | No |
| 2333 | 2804 | 1402.0 | 83.95 | 42.0 | Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. | D Filmer, L H Pritchett | Demography | 2001 | 11227840 | Yes |
| 2334 | 2804 | 1402.0 | 62.36 | 31.2 | Raster3D Version 2.0. A program for photorealistic molecular graphics. | E A Merritt, M E Murphy | Acta Crystallogr D Biol Crystallogr | 1994 | 15299354 | Yes |
| 2335 | 1402 | 1402.0 | 30.54 | 30.5 | The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. | R C Lewontin | Genetics | 1964 | 17248194 | Yes |
| 2336 | 1401 | 1401.0 | 0.0 | 0.0 | An approximate distribution of estimates of variance components. | F E Satterthwaite | Biometrics | 1946 | 20287815 | Yes |
| 2337 | 2801 | 1400.5 | 42.04 | 21.0 | Prediction of protein conformation. | P Y Chou, G D Fasman | Biochemistry | 1974 | 4358940 | Yes |
| 2338 | 1400 | 1400.0 | 31.99 | 32.0 | Protein kinase C: structure, function, and regulation. | A C Newton | J Biol Chem | 1995 | 7499357 | No |
| 2339 | 1400 | 1400.0 | 30.66 | 30.7 | The ATP synthase--a splendid molecular machine. | P D Boyer | Annu Rev Biochem | 1997 | 9242922 | No |
| 2340 | 1400 | 1400.0 | 40.51 | 40.5 | Depression in late life: review and commentary. | Dan G Blazer | J Gerontol A Biol Sci Med Sci | 2003 | 12634292 | No |
| 2341 | 2799 | 1399.5 | 68.91 | 34.5 | Myocardial reperfusion injury. | Derek M Yellon, Derek J Hausenloy | N Engl J Med | 2007 | 17855673 | No |
| 2342 | 1399 | 1399.0 | 28.84 | 28.8 | Origin of concatemeric T7 DNA. | J D Watson | Nat New Biol | 1972 | 4507727 | Yes |
| 2343 | 1399 | 1399.0 | 30.25 | 30.2 | Target-oriented and diversity-oriented organic synthesis in drug discovery. | S L Schreiber | Science | 2000 | 10720315 | No |
| 2344 | 1399 | 1399.0 | 125.46 | 125.5 | A Review of Coronavirus Disease-2019 (COVID-19). | Tanu Singhal | Indian J Pediatr | 2020 | 32166607 | No |
| 2345 | 1398 | 1398.0 | 33.31 | 33.3 | Drug-induced prolongation of the QT interval. | Dan M Roden | N Engl J Med | 2004 | 14999113 | No |
| 2346 | 1398 | 1398.0 | 56.96 | 57.0 | Transcriptional architecture of the mammalian circadian clock. | Joseph S Takahashi | Nat Rev Genet | 2017 | 27990019 | No |
| 2347 | 6986 | 1397.2 | 263.8 | 52.8 | Fsl. | Mark Jenkinson, Christian F Beckmann, Timothy E J Behrens, Mark W Woolrich, Stephen M Smith | Neuroimage | 2012 | 21979382 | No |
| 2348 | 2794 | 1397.0 | 82.26 | 41.1 | Glycine potentiates the NMDA response in cultured mouse brain neurons. | J W Johnson, P Ascher | Nature | 1987 | 2433595 | Yes |
| 2349 | 1397 | 1397.0 | 51.06 | 51.1 | The structure of beta-lactamases. | R P Ambler | Philos Trans R Soc Lond B Biol Sci | 1980 | 6109327 | Yes |
| 2350 | 2794 | 1397.0 | 61.36 | 30.7 | An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. | A A Beg, D Baltimore | Science | 1996 | 8864118 | Yes |
| 2351 | 4190 | 1396.7 | 197.24 | 65.7 | Risk factors for falls among elderly persons living in the community. | M E Tinetti, M Speechley, S F Ginter | N Engl J Med | 1988 | 3205267 | Yes |
| 2352 | 1396 | 1396.0 | 29.55 | 29.6 | Cancer of the ovary. | Stephen A Cannistra | N Engl J Med | 2004 | 15590954 | No |
| 2353 | 6978 | 1395.6 | 257.25 | 51.5 | Evidence based medicine: what it is and what it isn't. | D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S Richardson | BMJ | 1996 | 8555924 | No |
| 2354 | 2791 | 1395.5 | 74.61 | 37.3 | Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. | Robert E W Hancock, Hans-Georg Sahl | Nat Biotechnol | 2006 | 17160061 | No |
| 2355 | 1395 | 1395.0 | 17.36 | 17.4 | Hippocampal electrical activity and voluntary movement in the rat. | C H Vanderwolf | Electroencephalogr Clin Neurophysiol | 1969 | 4183562 | Yes |
| 2356 | 1395 | 1395.0 | 34.29 | 34.3 | The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. | R G Khalifah | J Biol Chem | 1971 | 4994926 | Yes |
| 2357 | 1395 | 1395.0 | 26.98 | 27.0 | Natively unfolded proteins: a point where biology waits for physics. | Vladimir N Uversky | Protein Sci | 2002 | 11910019 | No |
| 2358 | 2789 | 1394.5 | 81.7 | 40.9 | Microdetermination of long-chain fatty acids in plasma and tissues. | V P Dole, H Meinertz | J Biol Chem | 1960 | 13817286 | Yes |
| 2359 | 2789 | 1394.5 | 67.43 | 33.7 | Powering the planet: chemical challenges in solar energy utilization. | Nathan S Lewis, Daniel G Nocera | Proc Natl Acad Sci U S A | 2006 | 17043226 | Yes |
| 2360 | 1394 | 1394.0 | 49.99 | 50.0 | Quantitative methods in the review of epidemiologic literature. | S Greenland | Epidemiol Rev | 1987 | 3678409 | Yes |
| 2361 | 2788 | 1394.0 | 55.31 | 27.7 | Prediction of complete gene structures in human genomic DNA. | C Burge, S Karlin | J Mol Biol | 1997 | 9149143 | Yes |
| 2362 | 2788 | 1394.0 | 65.73 | 32.9 | Inflammation, stress, and diabetes. | Kathryn E Wellen, Gökhan S Hotamisligil | J Clin Invest | 2005 | 15864338 | No |
| 2363 | 2787 | 1393.5 | 70.11 | 35.1 | Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. | E Engvall, P Perlmann | Immunochemistry | 1971 | 5135623 | Yes |
| 2364 | 1393 | 1393.0 | 29.46 | 29.5 | A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. | Dale R Nyholt | Am J Hum Genet | 2004 | 14997420 | Yes |
| 2365 | 4179 | 1393.0 | 135.42 | 45.1 | Global estimates of the prevalence of diabetes for 2010 and 2030. | J E Shaw, R A Sicree, P Z Zimmet | Diabetes Res Clin Pract | 2010 | 19896746 | Yes |
| 2366 | 4176 | 1392.0 | 83.97 | 28.0 | The versatility and universality of calcium signalling. | M J Berridge, P Lipp, M D Bootman | Nat Rev Mol Cell Biol | 2000 | 11413485 | No |
| 2367 | 1392 | 1392.0 | 32.27 | 32.3 | Recent advances in neuroblastoma. | John M Maris | N Engl J Med | 2010 | 20558371 | No |
| 2368 | 2783 | 1391.5 | 85.03 | 42.5 | Molecular and cellular insights into T cell exhaustion. | E John Wherry, Makoto Kurachi | Nat Rev Immunol | 2015 | 26205583 | No |
| 2369 | 4174 | 1391.3 | 87.55 | 29.2 | Multidrug resistance in cancer: role of ATP-dependent transporters. | Michael M Gottesman, Tito Fojo, Susan E Bates | Nat Rev Cancer | 2002 | 11902585 | No |
| 2370 | 1391 | 1391.0 | 43.96 | 44.0 | The amazing osteocyte. | Lynda F Bonewald | J Bone Miner Res | 2011 | 21254230 | No |
| 2371 | 1391 | 1391.0 | 44.25 | 44.2 | Synopsis of some recent tactical application of bioisosteres in drug design. | Nicholas A Meanwell | J Med Chem | 2011 | 21413808 | Yes |
| 2372 | 2781 | 1390.5 | 108.21 | 54.1 | Natural products as sources of new drugs over the 30 years from 1981 to 2010. | David J Newman, Gordon M Cragg | J Nat Prod | 2012 | 22316239 | No |
| 2373 | 1390 | 1390.0 | 24.28 | 24.3 | The snail superfamily of zinc-finger transcription factors. | M Angela Nieto | Nat Rev Mol Cell Biol | 2002 | 11994736 | No |
| 2374 | 4166 | 1388.7 | 98.95 | 33.0 | Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. | Daniel Falush, Matthew Stephens, Jonathan K Pritchard | Genetics | 2003 | 12930761 | Yes |
| 2375 | 4165 | 1388.3 | 110.98 | 37.0 | TCS: a computer program to estimate gene genealogies. | M Clement, D Posada, K A Crandall | Mol Ecol | 2000 | 11050560 | Yes |
| 2376 | 1388 | 1388.0 | 52.73 | 52.7 | Presidential address, 1980. Surprise!...Surprise? | E Donchin | Psychophysiology | 1981 | 7280146 | Yes |
| 2377 | 2776 | 1388.0 | 80.3 | 40.1 | Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9164317 | Yes |
| 2378 | 1386 | 1386.0 | 36.91 | 36.9 | Sarcopenia: origins and clinical relevance. | I H Rosenberg | J Nutr | 1997 | 9164280 | No |
| 2379 | 2772 | 1386.0 | 89.13 | 44.6 | Origins and evolution of antibiotic resistance. | Julian Davies, Dorothy Davies | Microbiol Mol Biol Rev | 2010 | 20805405 | No |
| 2380 | 2771 | 1385.5 | 100.75 | 50.4 | Biology of disease: free radicals and tissue injury. | B A Freeman, J D Crapo | Lab Invest | 1982 | 6290784 | No |
| 2381 | 6927 | 1385.4 | 200.79 | 40.2 | Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. | Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E Walters | Arch Gen Psychiatry | 2005 | 15939839 | Yes |
| 2382 | 2770 | 1385.0 | 71.47 | 35.7 | A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. | J Messing, J Vieira | Gene | 1982 | 6295880 | Yes |
| 2383 | 1385 | 1385.0 | 52.19 | 52.2 | Translating social ecological theory into guidelines for community health promotion. | D Stokols | Am J Health Promot | 1996 | 10159709 | No |
| 2384 | 1385 | 1385.0 | 53.49 | 53.5 | What is self-rated health and why does it predict mortality? Towards a unified conceptual model. | Marja Jylhä | Soc Sci Med | 2009 | 19520474 | Yes |
| 2385 | 5539 | 1384.8 | 137.54 | 34.4 | Universal sample preparation method for proteome analysis. | Jacek R Wiśniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias Mann | Nat Methods | 2009 | 19377485 | Yes |
| 2386 | 2769 | 1384.5 | 94.65 | 47.3 | A new scale of social desirability independent of psychopathology. | D P Crowne, D Marlowe | J Consult Psychol | 1960 | 13813058 | Yes |
| 2387 | 1384 | 1384.0 | 29.99 | 30.0 | Physiological concentrations of purines and pyrimidines. | T W Traut | Mol Cell Biochem | 1994 | 7877593 | No |
| 2388 | 2768 | 1384.0 | 140.63 | 70.3 | Sensitivity Analysis in Observational Research: Introducing the E-Value. | Tyler J VanderWeele, Peng Ding | Ann Intern Med | 2017 | 28693043 | Yes |
| 2389 | 1383 | 1383.0 | 30.73 | 30.7 | Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. | M Kozak | Microbiol Rev | 1983 | 6343825 | No |
| 2390 | 2764 | 1382.0 | 91.49 | 45.7 | Social conditions as fundamental causes of disease. | B G Link, J Phelan | J Health Soc Behav | 1995 | 7560851 | No |
| 2391 | 1382 | 1382.0 | 0.0 | 0.0 | Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. | W C Schneider | J Biol Chem | 1948 | 18886166 | Yes |
| 2392 | 2763 | 1381.5 | 94.59 | 47.3 | Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. | D H Figurski, D R Helinski | Proc Natl Acad Sci U S A | 1979 | 377280 | Yes |
| 2393 | 2763 | 1381.5 | 63.14 | 31.6 | A method of trace iodination of proteins for immunologic studies. | P J McConahey, F J Dixon | Int Arch Allergy Appl Immunol | 1966 | 4160044 | Yes |
| 2394 | 1381 | 1381.0 | 32.34 | 32.3 | Regulation of differentiation of vascular smooth muscle cells. | G K Owens | Physiol Rev | 1995 | 7624392 | No |
| 2395 | 2762 | 1381.0 | 61.49 | 30.7 | Immunoassay of endogenous plasma insulin in man. | R S Yalow, S A Berson | J Clin Invest | 1960 | 13846364 | Yes |
| 2396 | 1381 | 1381.0 | 35.29 | 35.3 | The human orbitofrontal cortex: linking reward to hedonic experience. | Morten L Kringelbach | Nat Rev Neurosci | 2005 | 16136173 | No |
| 2397 | 2760 | 1380.0 | 85.25 | 42.6 | Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. | A Dahlstroem, K Fuxe | Acta Physiol Scand Suppl | 1964 | 14229500 | Yes |
| 2398 | 1380 | 1380.0 | 57.56 | 57.6 | 1,500 scientists lift the lid on reproducibility. | Monya Baker | Nature | 2016 | 27225100 | No |
| 2399 | 2758 | 1379.0 | 63.59 | 31.8 | Emerging roles of caspase-3 in apoptosis. | A G Porter, R U Jänicke | Cell Death Differ | 1999 | 10200555 | No |
| 2400 | 1379 | 1379.0 | 31.03 | 31.0 | Molecular basis of long-term plasticity underlying addiction. | E J Nestler | Nat Rev Neurosci | 2001 | 11252991 | No |
| 2401 | 5515 | 1378.8 | 208.09 | 52.0 | Bayesian phylogenetics with BEAUti and the BEAST 1.7. | Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew Rambaut | Mol Biol Evol | 2012 | 22367748 | Yes |
| 2402 | 6888 | 1377.6 | 167.34 | 33.5 | Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. | Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory Collins | Lancet | 2002 | 12493255 | Yes |
| 2403 | 1377 | 1377.0 | 42.88 | 42.9 | The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. | L W Swanson | Brain Res Bull | 1982 | 6816390 | Yes |
| 2404 | 2753 | 1376.5 | 73.93 | 37.0 | Antibiotic resistance of bacteria in biofilms. | P S Stewart, J W Costerton | Lancet | 2001 | 11463434 | No |
| 2405 | 1376 | 1376.0 | 59.72 | 59.7 | Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. | T Spector | Anal Biochem | 1978 | 655375 | Yes |
| 2406 | 1376 | 1376.0 | 0.0 | 0.0 | The critical incident technique. | J C Flanagan | Psychol Bull | 1954 | 13177800 | Yes |
| 2407 | 2752 | 1376.0 | 58.08 | 29.0 | LTP and LTD: an embarrassment of riches. | Robert C Malenka, Mark F Bear | Neuron | 2004 | 15450156 | No |
| 2408 | 1376 | 1376.0 | 48.27 | 48.3 | The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. | Eleonore Fröhlich | Int J Nanomedicine | 2012 | 23144561 | No |
| 2409 | 4127 | 1375.7 | 91.59 | 30.5 | Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. | Christian W Tornøe, Caspar Christensen, Morten Meldal | J Org Chem | 2002 | 11975567 | Yes |
| 2410 | 2750 | 1375.0 | 76.9 | 38.5 | Epidemiology of invasive candidiasis: a persistent public health problem. | M A Pfaller, D J Diekema | Clin Microbiol Rev | 2007 | 17223626 | No |
| 2411 | 2749 | 1374.5 | 70.41 | 35.2 | Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. | D Marion, K Wüthrich | Biochem Biophys Res Commun | 1983 | 6307308 | Yes |
| 2412 | 1374 | 1374.0 | 29.96 | 30.0 | The origin of the genetic code. | F H Crick | J Mol Biol | 1968 | 4887876 | Yes |
| 2413 | 2748 | 1374.0 | 109.98 | 55.0 | A typology of reviews: an analysis of 14 review types and associated methodologies. | Maria J Grant, Andrew Booth | Health Info Libr J | 2009 | 19490148 | No |
| 2414 | 4121 | 1373.7 | 100.43 | 33.5 | Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. | Y Zhang, M Brady, S Smith | IEEE Trans Med Imaging | 2001 | 11293691 | Yes |
| 2415 | 1373 | 1373.0 | 21.42 | 21.4 | Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. | J R David | Proc Natl Acad Sci U S A | 1966 | 5229858 | Yes |
| 2416 | 1373 | 1373.0 | 31.56 | 31.6 | Huntington's disease. | Francis O Walker | Lancet | 2007 | 17240289 | No |
| 2417 | 2746 | 1373.0 | 65.46 | 32.7 | Regulation mechanisms and signaling pathways of autophagy. | Congcong He, Daniel J Klionsky | Annu Rev Genet | 2009 | 19653858 | No |
| 2418 | 1372 | 1372.0 | 39.09 | 39.1 | Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. | P Willner | Psychopharmacology (Berl) | 1997 | 9452163 | No |
| 2419 | 1372 | 1372.0 | 36.54 | 36.5 | Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. | P Lips | Endocr Rev | 2001 | 11493580 | No |
| 2420 | 2743 | 1371.5 | 77.3 | 38.6 | Mortality by cause for eight regions of the world: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9142060 | Yes |
| 2421 | 1371 | 1371.0 | 22.33 | 22.3 | Cancer. Addiction to oncogenes--the Achilles heal of cancer. | I Bernard Weinstein | Science | 2002 | 12098689 | No |
| 2422 | 2740 | 1370.0 | 55.38 | 27.7 | Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. | A J Berk, P A Sharp | Cell | 1977 | 922889 | Yes |
| 2423 | 1370 | 1370.0 | 25.77 | 25.8 | Epithelial-mesenchymal transitions in development and pathologies. | Jean Paul Thiery | Curr Opin Cell Biol | 2003 | 14644200 | No |
| 2424 | 2739 | 1369.5 | 80.58 | 40.3 | A cognitive model of posttraumatic stress disorder. | A Ehlers, D M Clark | Behav Res Ther | 2000 | 10761279 | No |
| 2425 | 2738 | 1369.0 | 68.17 | 34.1 | The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. | Clay B Holroyd, Michael G H Coles | Psychol Rev | 2002 | 12374324 | Yes |
| 2426 | 2737 | 1368.5 | 87.7 | 43.9 | A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. | R L Juliano, V Ling | Biochim Biophys Acta | 1976 | 990323 | Yes |
| 2427 | 9579 | 1368.4 | 387.4 | 55.3 | Development and validation of a geriatric depression screening scale: a preliminary report. | J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O Leirer | J Psychiatr Res | 1982 | 7183759 | Yes |
| 2428 | 5473 | 1368.2 | 266.96 | 66.7 | Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. | Xiang Wan, Wenqian Wang, Jiming Liu, Tiejun Tong | BMC Med Res Methodol | 2014 | 25524443 | Yes |
| 2429 | 1368 | 1368.0 | 28.34 | 28.3 | Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. | R I Morimoto | Genes Dev | 1998 | 9869631 | No |
| 2430 | 1368 | 1368.0 | 30.04 | 30.0 | Diarylethenes for Memories and Switches. | Masahiro Irie | Chem Rev | 2000 | 11777416 | Yes |
| 2431 | 1368 | 1368.0 | 37.54 | 37.5 | The pollution of the marine environment by plastic debris: a review. | José G B Derraik | Mar Pollut Bull | 2002 | 12405208 | No |
| 2432 | 5472 | 1368.0 | 219.82 | 55.0 | QUAST: quality assessment tool for genome assemblies. | Alexey Gurevich, Vladislav Saveliev, Nikolay Vyahhi, Glenn Tesler | Bioinformatics | 2013 | 23422339 | Yes |
| 2433 | 1367 | 1367.0 | 27.87 | 27.9 | Stability and flexibility of epigenetic gene regulation in mammalian development. | Wolf Reik | Nature | 2007 | 17522676 | No |
| 2434 | 4100 | 1366.7 | 119.67 | 39.9 | Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. | J Garnier, D J Osguthorpe, B Robson | J Mol Biol | 1978 | 642007 | Yes |
| 2435 | 1366 | 1366.0 | 29.88 | 29.9 | Measuring information transfer | T Schreiber | Phys Rev Lett | 2000 | 10991308 | Yes |
| 2436 | 1366 | 1366.0 | 0.0 | 0.0 | An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. | O Smithies | Biochem J | 1959 | 13638269 | Yes |
| 2437 | 2731 | 1365.5 | 92.03 | 46.0 | Functional interactions between the gut microbiota and host metabolism. | Valentina Tremaroli, Fredrik Bäckhed | Nature | 2012 | 22972297 | No |
| 2438 | 1365 | 1365.0 | 46.84 | 46.8 | Multiple calcium channels and neuronal function. | R J Miller | Science | 1987 | 2432656 | No |
| 2439 | 1365 | 1365.0 | 42.64 | 42.6 | Glutathione metabolism and its selective modification. | A Meister | J Biol Chem | 1988 | 3053703 | No |
| 2440 | 2730 | 1365.0 | 73.86 | 36.9 | miRBase: integrating microRNA annotation and deep-sequencing data. | Ana Kozomara, Sam Griffiths-Jones | Nucleic Acids Res | 2011 | 21037258 | Yes |
| 2441 | 2730 | 1365.0 | 80.66 | 40.3 | The Measurement Of Selection On Correlated Characters. | Russell Lande, Stevan J Arnold | Evolution | 1983 | 28556011 | Yes |
| 2442 | 8188 | 1364.7 | 205.61 | 34.3 | A default mode of brain function. | M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L Shulman | Proc Natl Acad Sci U S A | 2001 | 11209064 | Yes |
| 2443 | 2729 | 1364.5 | 59.33 | 29.7 | NMR View: A computer program for the visualization and analysis of NMR data. | B A Johnson, R A Blevins | J Biomol NMR | 1994 | 22911360 | Yes |
| 2444 | 2728 | 1364.0 | 66.3 | 33.1 | The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. | Daniel J Drucker, Michael A Nauck | Lancet | 2006 | 17098089 | No |
| 2445 | 1364 | 1364.0 | 36.35 | 36.4 | Atopic dermatitis. | Thomas Bieber | N Engl J Med | 2008 | 18385500 | Yes |
| 2446 | 2727 | 1363.5 | 61.56 | 30.8 | Disruption of epithelial cell-matrix interactions induces apoptosis. | S M Frisch, H Francis | J Cell Biol | 1994 | 8106557 | Yes |
| 2447 | 2726 | 1363.0 | 95.97 | 48.0 | A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. | C M Tsai, C E Frasch | Anal Biochem | 1982 | 6176137 | Yes |
| 2448 | 2726 | 1363.0 | 0.0 | 0.0 | The respiratory chain and oxidative phosphorylation. | B Chance, G R Williams | Adv Enzymol Relat Subj Biochem | 1956 | 13313307 | Yes |
| 2449 | 4089 | 1363.0 | 116.82 | 38.9 | A rapid bootstrap algorithm for the RAxML Web servers. | Alexandros Stamatakis, Paul Hoover, Jacques Rougemont | Syst Biol | 2008 | 18853362 | Yes |
| 2450 | 1363 | 1363.0 | 40.56 | 40.6 | Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. | Chao-Jun Li | Acc Chem Res | 2009 | 19220064 | Yes |
| 2451 | 2724 | 1362.0 | 52.18 | 26.1 | A protein sequenator. | P Edman, G Begg | Eur J Biochem | 1967 | 6059350 | Yes |
| 2452 | 1362 | 1362.0 | 24.66 | 24.7 | c-Myc target genes involved in cell growth, apoptosis, and metabolism. | C V Dang | Mol Cell Biol | 1999 | 9858526 | No |
| 2453 | 2724 | 1362.0 | 84.22 | 42.1 | Tumor-associated macrophages: from mechanisms to therapy. | Roy Noy, Jeffrey W Pollard | Immunity | 2014 | 25035953 | No |
| 2454 | 2723 | 1361.5 | 56.15 | 28.1 | Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. | P J Southern, P Berg | J Mol Appl Genet | 1982 | 6286831 | Yes |
| 2455 | 1361 | 1361.0 | 29.13 | 29.1 | Codon usage and tRNA content in unicellular and multicellular organisms. | T Ikemura | Mol Biol Evol | 1985 | 3916708 | No |
| 2456 | 1361 | 1361.0 | 46.35 | 46.4 | Interleukin-1. | C A Dinarello | Rev Infect Dis | 1984 | 6369481 | No |
| 2457 | 1361 | 1361.0 | 31.21 | 31.2 | Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? | Rui Wang | FASEB J | 2002 | 12409322 | Yes |
| 2458 | 1361 | 1361.0 | 29.76 | 29.8 | Transcriptional control of adipocyte formation. | Stephen R Farmer | Cell Metab | 2006 | 17011499 | No |
| 2459 | 1361 | 1361.0 | 63.43 | 63.4 | Biological roles of glycans. | Ajit Varki | Glycobiology | 2017 | 27558841 | No |
| 2460 | 2721 | 1360.5 | 76.16 | 38.1 | The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. | W L Jorgensen, J Tirado-Rives | J Am Chem Soc | 1988 | 27557051 | Yes |
| 2461 | 1360 | 1360.0 | 43.03 | 43.0 | Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. | A A Grace | Neuroscience | 1991 | 1676137 | No |
| 2462 | 1360 | 1360.0 | 24.07 | 24.1 | Chromatin modification and epigenetic reprogramming in mammalian development. | En Li | Nat Rev Genet | 2002 | 12209141 | No |
| 2463 | 1360 | 1360.0 | 28.48 | 28.5 | The enzymes, regulation, and genetics of bile acid synthesis. | David W Russell | Annu Rev Biochem | 2003 | 12543708 | No |
| 2464 | 2719 | 1359.5 | 66.19 | 33.1 | Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. | M P Lutolf, J A Hubbell | Nat Biotechnol | 2005 | 15637621 | No |
| 2465 | 1359 | 1359.0 | 32.71 | 32.7 | Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. | G von Heijne | J Mol Biol | 1992 | 1593632 | Yes |
| 2466 | 1359 | 1359.0 | 0.0 | 0.0 | Effects of varying the vehicle for OsO4 in tissue fixation. | J B Caulfield | J Biophys Biochem Cytol | 1957 | 13475399 | Yes |
| 2467 | 1359 | 1359.0 | 45.69 | 45.7 | AmpC beta-lactamases. | George A Jacoby | Clin Microbiol Rev | 2009 | 19136439 | No |
| 2468 | 2717 | 1358.5 | 128.52 | 64.3 | Glutathione peroxidase activity in selenium-deficient rat liver. | R A Lawrence, R F Burk | Biochem Biophys Res Commun | 1976 | 971321 | Yes |
| 2469 | 1358 | 1358.0 | 60.24 | 60.2 | Displaced proximal humeral fractures. I. Classification and evaluation. | C S Neer | J Bone Joint Surg Am | 1970 | 5455339 | Yes |
| 2470 | 4074 | 1358.0 | 140.88 | 47.0 | Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. | Marina Colombo, Graça Raposo, Clotilde Théry | Annu Rev Cell Dev Biol | 2014 | 25288114 | No |
| 2471 | 1358 | 1358.0 | 106.64 | 106.6 | Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. | Jonas F Ludvigsson | Acta Paediatr | 2020 | 32202343 | Yes |
| 2472 | 1357 | 1357.0 | 43.48 | 43.5 | History of the Rochester Epidemiology Project. | L J Melton | Mayo Clin Proc | 1996 | 8594285 | No |
| 2473 | 9498 | 1356.9 | 236.63 | 33.8 | Integrative genomics viewer. | James T Robinson, Helga Thorvaldsdóttir, Wendy Winckler, Mitchell Guttman, Eric S Lander, Gad Getz, Jill P Mesirov | Nat Biotechnol | 2011 | 21221095 | Yes |
| 2474 | 1356 | 1356.0 | 28.69 | 28.7 | HIF-1: mediator of physiological and pathophysiological responses to hypoxia. | G L Semenza | J Appl Physiol (1985) | 2000 | 10749844 | No |
| 2475 | 1356 | 1356.0 | 31.76 | 31.8 | Non-Smad pathways in TGF-beta signaling. | Ying E Zhang | Cell Res | 2009 | 19114990 | No |
| 2476 | 1355 | 1355.0 | 27.5 | 27.5 | The many faces of macrophage activation. | David M Mosser | J Leukoc Biol | 2003 | 12554797 | No |
| 2477 | 1355 | 1355.0 | 41.81 | 41.8 | Electrocatalyst approaches and challenges for automotive fuel cells. | Mark K Debe | Nature | 2012 | 22678278 | Yes |
| 2478 | 2709 | 1354.5 | 55.13 | 27.6 | Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. | J M Kyriakis, J Avruch | Physiol Rev | 2001 | 11274345 | No |
| 2479 | 1354 | 1354.0 | 64.7 | 64.7 | Molecular pathology of schizophrenia: more than one disease process? | T J Crow | Br Med J | 1980 | 6101544 | No |
| 2480 | 1354 | 1354.0 | 28.07 | 28.1 | Human natural killer cells. | Michael A Caligiuri | Blood | 2008 | 18650461 | No |
| 2481 | 1354 | 1354.0 | 56.04 | 56.0 | Rhythms for Cognition: Communication through Coherence. | Pascal Fries | Neuron | 2015 | 26447583 | No |
| 2482 | 2707 | 1353.5 | 85.29 | 42.6 | DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI. | Yan Chao-Gan, Zang Yu-Feng | Front Syst Neurosci | 2010 | 20577591 | Yes |
| 2483 | 2706 | 1353.0 | 72.15 | 36.1 | Tumor metastasis: molecular insights and evolving paradigms. | Scott Valastyan, Robert A Weinberg | Cell | 2011 | 22000009 | No |
| 2484 | 1352 | 1352.0 | 34.65 | 34.6 | The biologic clock: the mitochondria? | D Harman | J Am Geriatr Soc | 1972 | 5016631 | Yes |
| 2485 | 1352 | 1352.0 | 52.44 | 52.4 | Blood gas calculator. | J W Severinghaus | J Appl Physiol | 1966 | 5912737 | Yes |
| 2486 | 1352 | 1352.0 | 34.27 | 34.3 | Microbial influences in inflammatory bowel diseases. | R Balfour Sartor | Gastroenterology | 2008 | 18242222 | No |
| 2487 | 2702 | 1351.0 | 62.29 | 31.1 | NF-kappa B: ten years after. | P A Baeuerle, D Baltimore | Cell | 1996 | 8858144 | No |
| 2488 | 1351 | 1351.0 | 37.61 | 37.6 | Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. | Felix Kratz | J Control Release | 2008 | 18582981 | No |
| 2489 | 2701 | 1350.5 | 64.5 | 32.2 | Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. | Subhra K Biswas, Alberto Mantovani | Nat Immunol | 2010 | 20856220 | No |
| 2490 | 6751 | 1350.2 | 182.69 | 36.5 | Transection of the oesophagus for bleeding oesophageal varices. | R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R Williams | Br J Surg | 1973 | 4541913 | Yes |
| 2491 | 4050 | 1350.0 | 49.81 | 16.6 | Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. | D D Sabatini, K Bensch, R J Barrnett | J Cell Biol | 1963 | 13975866 | Yes |
| 2492 | 1350 | 1350.0 | 56.7 | 56.7 | The Laboratory Rat: Relating Its Age With Human's. | Pallav Sengupta | Int J Prev Med | 2013 | 23930179 | Yes |
| 2493 | 2699 | 1349.5 | 93.68 | 46.8 | Total energy intake: implications for epidemiologic analyses. | W Willett, M J Stampfer | Am J Epidemiol | 1986 | 3521261 | No |
| 2494 | 1349 | 1349.0 | 41.15 | 41.1 | Neurotransmitters and neuromodulators in the basal ganglia. | A M Graybiel | Trends Neurosci | 1990 | 1695398 | No |
| 2495 | 1349 | 1349.0 | 20.49 | 20.5 | A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. | A M Olovnikov | J Theor Biol | 1973 | 4754905 | Yes |
| 2496 | 1349 | 1349.0 | 41.39 | 41.4 | Chronic disease management: what will it take to improve care for chronic illness? | E H Wagner | Eff Clin Pract | 1998 | 10345255 | No |
| 2497 | 1349 | 1349.0 | 25.82 | 25.8 | Mechanisms of caspase activation and inhibition during apoptosis. | Yigong Shi | Mol Cell | 2002 | 11931755 | No |
| 2498 | 1349 | 1349.0 | 11.77 | 11.8 | Immunological function of the thymus. | J F Miller | Lancet | 1961 | 14474038 | Yes |
| 2499 | 1349 | 1349.0 | 50.23 | 50.2 | Microtiter dish biofilm formation assay. | George A O'Toole | J Vis Exp | 2011 | 21307833 | Yes |
| 2500 | 1348 | 1348.0 | 41.76 | 41.8 | Renin-angiotensin system: biochemistry and mechanisms of action. | M J Peach | Physiol Rev | 1977 | 191856 | No |
| 2501 | 1348 | 1348.0 | 26.87 | 26.9 | Dimerization of cell surface receptors in signal transduction. | C H Heldin | Cell | 1995 | 7834741 | No |
| 2502 | 5390 | 1347.5 | 232.09 | 58.0 | Progressive statistics for studies in sports medicine and exercise science. | William G Hopkins, Stephen W Marshall, Alan M Batterham, Juri Hanin | Med Sci Sports Exerc | 2009 | 19092709 | No |
| 2503 | 1347 | 1347.0 | 49.42 | 49.4 | Letter: Grading of angina pectoris. | L Campeau | Circulation | 1976 | 947585 | Yes |
| 2504 | 1347 | 1347.0 | 25.93 | 25.9 | Chromosomal translocations in human cancer. | T H Rabbitts | Nature | 1994 | 7969446 | No |
| 2505 | 1347 | 1347.0 | 33.67 | 33.7 | A molecular view of microbial diversity and the biosphere. | N R Pace | Science | 1997 | 9115194 | No |
| 2506 | 5388 | 1347.0 | 126.72 | 31.7 | The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. | Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten Schwede | Bioinformatics | 2006 | 16301204 | Yes |
| 2507 | 1346 | 1346.0 | 51.55 | 51.5 | Minority stress and mental health in gay men. | I H Meyer | J Health Soc Behav | 1995 | 7738327 | Yes |
| 2508 | 1346 | 1346.0 | 35.54 | 35.5 | Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. | S L Friedman | N Engl J Med | 1993 | 8502273 | No |
| 2509 | 1346 | 1346.0 | 70.53 | 70.5 | ROS Are Good. | Ron Mittler | Trends Plant Sci | 2017 | 27666517 | No |
| 2510 | 5380 | 1345.0 | 123.89 | 31.0 | Quantitative monitoring of gene expression patterns with a complementary DNA microarray. | M Schena, D Shalon, R W Davis, P O Brown | Science | 1995 | 7569999 | Yes |
| 2511 | 1345 | 1345.0 | 0.0 | 0.0 | A simple ultraviolet spectrophotometric method for the determination of protein. | W J Waddell | J Lab Clin Med | 1956 | 13346201 | Yes |
| 2512 | 1345 | 1345.0 | 40.98 | 41.0 | Nanobodies: natural single-domain antibodies. | Serge Muyldermans | Annu Rev Biochem | 2013 | 23495938 | No |
| 2513 | 1344 | 1344.0 | 39.83 | 39.8 | Classification of chronic viral hepatitis: a need for reassessment. | P J Scheuer | J Hepatol | 1991 | 1808228 | No |
| 2514 | 1344 | 1344.0 | 64.21 | 64.2 | The clinical application of the biopsychosocial model. | G L Engel | Am J Psychiatry | 1980 | 7369396 | Yes |
| 2515 | 1344 | 1344.0 | 102.8 | 102.8 | The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) - China, 2020. | The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team | China CDC Wkly | 2020 | 34594836 | Yes |
| 2516 | 1343 | 1343.0 | 44.1 | 44.1 | Phenylpropanoid biosynthesis. | Thomas Vogt | Mol Plant | 2010 | 20035037 | No |
| 2517 | 2684 | 1342.0 | 61.31 | 30.7 | The RXR heterodimers and orphan receptors. | D J Mangelsdorf, R M Evans | Cell | 1995 | 8521508 | No |
| 2518 | 1342 | 1342.0 | 39.75 | 39.8 | Circuitry and functional aspects of the insular lobe in primates including humans. | J R Augustine | Brain Res Brain Res Rev | 1996 | 8957561 | No |
| 2519 | 1341 | 1341.0 | 44.76 | 44.8 | Optimal foraging, the marginal value theorem. | E L Charnov | Theor Popul Biol | 1976 | 1273796 | Yes |
| 2520 | 1341 | 1341.0 | 25.64 | 25.6 | microRNAs: tiny regulators with great potential. | V Ambros | Cell | 2001 | 11779458 | No |
| 2521 | 1341 | 1341.0 | 23.02 | 23.0 | Protein modification by SUMO. | Erica S Johnson | Annu Rev Biochem | 2004 | 15189146 | No |
| 2522 | 1341 | 1341.0 | 27.32 | 27.3 | Solving structures of protein complexes by molecular replacement with Phaser. | Airlie J McCoy | Acta Crystallogr D Biol Crystallogr | 2007 | 17164524 | Yes |
| 2523 | 1341 | 1341.0 | 30.29 | 30.3 | Tumour necrosis factor and cancer. | Frances Balkwill | Nat Rev Cancer | 2009 | 19343034 | No |
| 2524 | 2681 | 1340.5 | 108.6 | 54.3 | The Warburg Effect: How Does it Benefit Cancer Cells? | Maria V Liberti, Jason W Locasale | Trends Biochem Sci | 2016 | 26778478 | No |
| 2525 | 4021 | 1340.3 | 88.01 | 29.3 | Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. | Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen | Science | 2005 | 15831717 | Yes |
| 2526 | 1340 | 1340.0 | 35.6 | 35.6 | Fibronectin and its receptors. | E Ruoslahti | Annu Rev Biochem | 1988 | 2972252 | No |
| 2527 | 1340 | 1340.0 | 44.84 | 44.8 | Functional organization of central pathways regulating the cardiovascular system. | R A Dampney | Physiol Rev | 1994 | 8171117 | No |
| 2528 | 1340 | 1340.0 | 30.2 | 30.2 | Physiological and molecular basis of thyroid hormone action. | P M Yen | Physiol Rev | 2001 | 11427693 | No |
| 2529 | 2680 | 1340.0 | 106.14 | 53.1 | Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. | Roel Nusse, Hans Clevers | Cell | 2017 | 28575679 | No |
| 2530 | 2678 | 1339.0 | 90.25 | 45.1 | Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. | G J Miller, N E Miller | Lancet | 1975 | 46338 | Yes |
| 2531 | 2678 | 1339.0 | 61.55 | 30.8 | Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. | G Blobel, B Dobberstein | J Cell Biol | 1975 | 811671 | Yes |
| 2532 | 1338 | 1338.0 | 73.37 | 73.4 | DLS and zeta potential - What they are and what they are not? | Sourav Bhattacharjee | J Control Release | 2016 | 27297779 | No |
| 2533 | 2675 | 1337.5 | 64.6 | 32.3 | Microglia: active sensor and versatile effector cells in the normal and pathologic brain. | Uwe-Karsten Hanisch, Helmut Kettenmann | Nat Neurosci | 2007 | 17965659 | No |
| 2534 | 1337 | 1337.0 | 25.14 | 25.1 | A modified procedure for lead staining of thin sections. | G Millonig | J Biophys Biochem Cytol | 1961 | 14474176 | Yes |
| 2535 | 4011 | 1337.0 | 90.68 | 30.2 | Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? | Witold Filipowicz, Suvendra N Bhattacharyya, Nahum Sonenberg | Nat Rev Genet | 2008 | 18197166 | No |
| 2536 | 2673 | 1336.5 | 73.28 | 36.6 | A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. | B G Durie, S E Salmon | Cancer | 1975 | 1182674 | Yes |
| 2537 | 2673 | 1336.5 | 60.02 | 30.0 | Cell cycle, CDKs and cancer: a changing paradigm. | Marcos Malumbres, Mariano Barbacid | Nat Rev Cancer | 2009 | 19238148 | No |
| 2538 | 1336 | 1336.0 | 28.56 | 28.6 | The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. | G B Morin | Cell | 1989 | 2805070 | Yes |
| 2539 | 1336 | 1336.0 | 35.84 | 35.8 | Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. | E B Hunziker | Osteoarthritis Cartilage | 2002 | 12056848 | No |
| 2540 | 2672 | 1336.0 | 67.45 | 33.7 | Therapeutic potential of resveratrol: the in vivo evidence. | Joseph A Baur, David A Sinclair | Nat Rev Drug Discov | 2006 | 16732220 | No |
| 2541 | 1335 | 1335.0 | 34.89 | 34.9 | The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. | K Kuwajima | Proteins | 1989 | 2695928 | No |
| 2542 | 1335 | 1335.0 | 47.09 | 47.1 | Neuropeptide Y: complete amino acid sequence of the brain peptide. | K Tatemoto | Proc Natl Acad Sci U S A | 1982 | 6957876 | Yes |
| 2543 | 1335 | 1335.0 | 41.79 | 41.8 | The phenomenon of the acute phase response. | I Kushner | Ann N Y Acad Sci | 1982 | 7046585 | No |
| 2544 | 2670 | 1335.0 | 59.38 | 29.7 | A comparison of bayesian methods for haplotype reconstruction from population genotype data. | Matthew Stephens, Peter Donnelly | Am J Hum Genet | 2003 | 14574645 | Yes |
| 2545 | 1335 | 1335.0 | 32.92 | 32.9 | N-heterocyclic carbenes: a new concept in organometallic catalysis. | Wolfgang A Herrmann | Angew Chem Int Ed Engl | 2002 | 19750753 | Yes |
| 2546 | 2669 | 1334.5 | 79.85 | 39.9 | Further improvements in the plaque technique for detecting single antibody-forming cells. | A J Cunningham, A Szenberg | Immunology | 1968 | 5653817 | Yes |
| 2547 | 4002 | 1334.0 | 100.29 | 33.4 | LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. | A C Wallace, R A Laskowski, J M Thornton | Protein Eng | 1995 | 7630882 | Yes |
| 2548 | 5333 | 1333.2 | 117.33 | 29.3 | Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. | Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J Thun | N Engl J Med | 2003 | 12711737 | Yes |
| 2549 | 1333 | 1333.0 | 33.93 | 33.9 | Thioredoxin and glutaredoxin systems. | A Holmgren | J Biol Chem | 1989 | 2668278 | No |
| 2550 | 1333 | 1333.0 | 25.68 | 25.7 | Stereological principles for morphometry in electron microscopic cytology. | E R Weibel | Int Rev Cytol | 1969 | 4899604 | No |
| 2551 | 1333 | 1333.0 | 33.28 | 33.3 | Comparative physiology of salt and water stress. | R. Munns | Plant Cell Environ | 2002 | 11841667 | Yes |
| 2552 | 2665 | 1332.5 | 53.87 | 26.9 | Regulated portals of entry into the cell. | Sean D Conner, Sandra L Schmid | Nature | 2003 | 12621426 | No |
| 2553 | 1332 | 1332.0 | 30.17 | 30.2 | Metastatic bone disease: clinical features, pathophysiology and treatment strategies. | R E Coleman | Cancer Treat Rev | 2001 | 11417967 | No |
| 2554 | 1332 | 1332.0 | 41.78 | 41.8 | Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. | Thomas Heberer | Toxicol Lett | 2002 | 11988354 | Yes |
| 2555 | 3993 | 1331.0 | 102.61 | 34.2 | Cognitive and emotional influences in anterior cingulate cortex. | G Bush, P Luu, M I Posner | Trends Cogn Sci | 2000 | 10827444 | Yes |
| 2556 | 1331 | 1331.0 | 23.4 | 23.4 | SUMO: a history of modification. | Ronald T Hay | Mol Cell | 2005 | 15808504 | No |
| 2557 | 2661 | 1330.5 | 71.13 | 35.6 | Chlorophyll fluorescence--a practical guide. | K Maxwell, G N Johnson | J Exp Bot | 2000 | 10938857 | No |
| 2558 | 1330 | 1330.0 | 48.05 | 48.0 | The life and times of the Enterococcus. | B E Murray | Clin Microbiol Rev | 1990 | 2404568 | No |
| 2559 | 1330 | 1330.0 | 34.65 | 34.6 | The aryl hydrocarbon receptor complex. | O Hankinson | Annu Rev Pharmacol Toxicol | 1995 | 7598497 | No |
| 2560 | 3990 | 1330.0 | 107.13 | 35.7 | Nitric oxide and peroxynitrite in health and disease. | Pál Pacher, Joseph S Beckman, Lucas Liaudet | Physiol Rev | 2007 | 17237348 | No |
| 2561 | 2659 | 1329.5 | 61.32 | 30.7 | Microenvironmental regulation of metastasis. | Johanna A Joyce, Jeffrey W Pollard | Nat Rev Cancer | 2009 | 19279573 | No |
| 2562 | 5317 | 1329.2 | 131.35 | 32.8 | Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. | D W Cleveland, S G Fischer, M W Kirschner, U K Laemmli | J Biol Chem | 1977 | 320200 | Yes |
| 2563 | 1329 | 1329.0 | 0.0 | 0.0 | The anterior approach for removal of ruptured cervical disks. | R B Cloward | J Neurosurg | 1958 | 13599052 | Yes |
| 2564 | 1329 | 1329.0 | 38.6 | 38.6 | Endometriosis. | Serdar E Bulun | N Engl J Med | 2009 | 19144942 | No |
| 2565 | 1328 | 1328.0 | 28.35 | 28.4 | Mechanisms of foxp3+ T regulatory cell-mediated suppression. | Ethan M Shevach | Immunity | 2009 | 19464986 | No |
| 2566 | 1328 | 1328.0 | 37.69 | 37.7 | Subcutaneous and visceral adipose tissue: structural and functional differences. | M Mohsen Ibrahim | Obes Rev | 2010 | 19656312 | No |
| 2567 | 1327 | 1327.0 | 40.92 | 40.9 | Evaluating the quality of medical care. 1966. | Avedis Donabedian | Milbank Q | 2005 | 16279964 | No |
| 2568 | 2653 | 1326.5 | 58.05 | 29.0 | Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. | Jane E Visvader, Geoffrey J Lindeman | Nat Rev Cancer | 2008 | 18784658 | No |
| 2569 | 2652 | 1326.0 | 55.73 | 27.9 | Liver regeneration. | G K Michalopoulos, M C DeFrances | Science | 1997 | 9082986 | No |
| 2570 | 1326 | 1326.0 | 37.64 | 37.6 | Cytokinesis-block micronucleus cytome assay. | Michael Fenech | Nat Protoc | 2007 | 17546000 | Yes |
| 2571 | 3977 | 1325.7 | 134.31 | 44.8 | Job burnout. | C Maslach, W B Schaufeli, M P Leiter | Annu Rev Psychol | 2001 | 11148311 | Yes |
| 2572 | 1325 | 1325.0 | 29.89 | 29.9 | Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. | W D Snider | Cell | 1994 | 8205613 | No |
| 2573 | 1325 | 1325.0 | 13.19 | 13.2 | Cellular resistance to infection. | G B Mackaness | J Exp Med | 1962 | 14467923 | Yes |
| 2574 | 6624 | 1324.8 | 351.26 | 70.3 | ModelFinder: fast model selection for accurate phylogenetic estimates. | Subha Kalyaanamoorthy, Bui Quang Minh, Thomas K F Wong, Arndt von Haeseler, Lars S Jermiin | Nat Methods | 2017 | 28481363 | Yes |
| 2575 | 1324 | 1324.0 | 79.93 | 79.9 | A comparison of canal preparations in straight and curved root canals. | S W Schneider | Oral Surg Oral Med Oral Pathol | 1971 | 5284110 | Yes |
| 2576 | 1324 | 1324.0 | 38.49 | 38.5 | Osteoblast adhesion on biomaterials. | K Anselme | Biomaterials | 2000 | 10711964 | No |
| 2577 | 2648 | 1324.0 | 62.99 | 31.5 | C-reactive protein: a critical update. | Mark B Pepys, Gideon M Hirschfield | J Clin Invest | 2003 | 12813013 | No |
| 2578 | 2648 | 1324.0 | 76.0 | 38.0 | Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. | Aluísio J D Barros, Vânia N Hirakata | BMC Med Res Methodol | 2003 | 14567763 | Yes |
| 2579 | 2647 | 1323.5 | 46.6 | 23.3 | Rab proteins as membrane organizers. | M Zerial, H McBride | Nat Rev Mol Cell Biol | 2001 | 11252952 | No |
| 2580 | 1323 | 1323.0 | 50.6 | 50.6 | Free-radical mechanisms in tissue injury. | T F Slater | Biochem J | 1984 | 6383353 | No |
| 2581 | 1323 | 1323.0 | 0.0 | 0.0 | On the psychophysical law. | S S Stevens | Psychol Rev | 1957 | 13441853 | Yes |
| 2582 | 3969 | 1323.0 | 102.53 | 34.2 | Bacterial biofilms: from the natural environment to infectious diseases. | Luanne Hall-Stoodley, J William Costerton, Paul Stoodley | Nat Rev Microbiol | 2004 | 15040259 | No |
| 2583 | 1323 | 1323.0 | 35.58 | 35.6 | Polycystic ovary syndrome. | David A Ehrmann | N Engl J Med | 2005 | 15788499 | No |
| 2584 | 2644 | 1322.0 | 100.63 | 50.3 | Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. | E Engvall, P Perlmann | J Immunol | 1972 | 4113792 | Yes |
| 2585 | 2644 | 1322.0 | 60.18 | 30.1 | Integrins and signal transduction pathways: the road taken. | E A Clark, J S Brugge | Science | 1995 | 7716514 | No |
| 2586 | 1322 | 1322.0 | 38.99 | 39.0 | Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? | Thomas Grobner | Nephrol Dial Transplant | 2006 | 16431890 | Yes |
| 2587 | 2643 | 1321.5 | 121.15 | 60.6 | Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. | J M Tanner, R H Whitehouse | Arch Dis Child | 1976 | 952550 | Yes |
| 2588 | 6607 | 1321.4 | 124.4 | 24.9 | Crystal structure of the nucleosome core particle at 2.8 A resolution. | K Luger, A W Mäder, R K Richmond, D F Sargent, T J Richmond | Nature | 1997 | 9305837 | Yes |
| 2589 | 2642 | 1321.0 | 49.07 | 24.5 | New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. | R D Gietz, A Sugino | Gene | 1988 | 3073106 | Yes |
| 2590 | 2642 | 1321.0 | 68.24 | 34.1 | Apoptosis, oncosis, and necrosis. An overview of cell death. | G Majno, I Joris | Am J Pathol | 1995 | 7856735 | No |
| 2591 | 1321 | 1321.0 | 32.27 | 32.3 | Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. | G L Semenza | Oncogene | 2010 | 19946328 | No |
| 2592 | 2641 | 1320.5 | 55.97 | 28.0 | The canonical Notch signaling pathway: unfolding the activation mechanism. | Raphael Kopan, Maria Xenia G Ilagan | Cell | 2009 | 19379690 | No |
| 2593 | 3960 | 1320.0 | 97.45 | 32.5 | The p53 tumour suppressor gene. | A J Levine, J Momand, C A Finlay | Nature | 1991 | 2046748 | No |
| 2594 | 1320 | 1320.0 | 54.75 | 54.8 | Error in medicine. | L L Leape | JAMA | 1994 | 7503827 | Yes |
| 2595 | 2638 | 1319.0 | 56.63 | 28.3 | Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. | M Zuker, P Stiegler | Nucleic Acids Res | 1981 | 6163133 | Yes |
| 2596 | 1319 | 1319.0 | 23.04 | 23.0 | Clonal selection and learning in the antibody system. | K Rajewsky | Nature | 1996 | 8657279 | No |
| 2597 | 1319 | 1319.0 | 22.87 | 22.9 | Regulatory T cells: key controllers of immunologic self-tolerance. | S Sakaguchi | Cell | 2000 | 10850488 | No |
| 2598 | 1319 | 1319.0 | 34.97 | 35.0 | Levels of racism: a theoretic framework and a gardener's tale. | C P Jones | Am J Public Health | 2000 | 10936998 | Yes |
| 2599 | 2637 | 1318.5 | 77.74 | 38.9 | Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. | Christine Vogel, Edward M Marcotte | Nat Rev Genet | 2012 | 22411467 | No |
| 2600 | 1318 | 1318.0 | 34.13 | 34.1 | The sympathetic control of blood pressure. | Patrice G Guyenet | Nat Rev Neurosci | 2006 | 16760914 | No |
| 2601 | 1318 | 1318.0 | 35.2 | 35.2 | Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. | Arnold I Caplan | J Cell Physiol | 2007 | 17620285 | No |
| 2602 | 7907 | 1317.8 | 199.43 | 33.2 | Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. | Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat Robles | Bioinformatics | 2005 | 16081474 | Yes |
| 2603 | 1317 | 1317.0 | 17.08 | 17.1 | Disconnexion syndromes in animals and man. I. | N Geschwind | Brain | 1965 | 5318481 | No |
| 2604 | 1317 | 1317.0 | 31.48 | 31.5 | Apoptosis in cancer therapy: crossing the threshold. | D E Fisher | Cell | 1994 | 8069905 | No |
| 2605 | 3951 | 1317.0 | 80.72 | 26.9 | Calcium signalling: dynamics, homeostasis and remodelling. | Michael J Berridge, Martin D Bootman, H Llewelyn Roderick | Nat Rev Mol Cell Biol | 2003 | 12838335 | No |
| 2606 | 1317 | 1317.0 | 42.62 | 42.6 | The epidemiology of adult obstructive sleep apnea. | Naresh M Punjabi | Proc Am Thorac Soc | 2008 | 18250205 | No |
| 2607 | 3949 | 1316.3 | 83.55 | 27.8 | A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. | R Medzhitov, P Preston-Hurlburt, C A Janeway | Nature | 1997 | 9237759 | Yes |
| 2608 | 5264 | 1316.0 | 123.64 | 30.9 | Improved prediction of signal peptides: SignalP 3.0. | Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren Brunak | J Mol Biol | 2004 | 15223320 | Yes |
| 2609 | 3947 | 1315.7 | 140.91 | 47.0 | A new method for off-line removal of ocular artifact. | G Gratton, M G Coles, E Donchin | Electroencephalogr Clin Neurophysiol | 1983 | 6187540 | Yes |
| 2610 | 3947 | 1315.7 | 93.32 | 31.1 | Functional porous coordination polymers. | Susumu Kitagawa, Ryo Kitaura, Shin-ichiro Noro | Angew Chem Int Ed Engl | 2004 | 15114565 | Yes |
| 2611 | 3947 | 1315.7 | 91.21 | 30.4 | Tissue cells feel and respond to the stiffness of their substrate. | Dennis E Discher, Paul Janmey, Yu-Li Wang | Science | 2005 | 16293750 | No |
| 2612 | 2631 | 1315.5 | 100.89 | 50.4 | Malondialdehyde determination as index of lipid peroxidation. | H H Draper, M Hadley | Methods Enzymol | 1990 | 2233309 | Yes |
| 2613 | 1315 | 1315.0 | 44.5 | 44.5 | Carnitine--metabolism and functions. | J Bremer | Physiol Rev | 1983 | 6361812 | No |
| 2614 | 1315 | 1315.0 | 40.95 | 41.0 | Thermal properties of graphene and nanostructured carbon materials. | Alexander A Balandin | Nat Mater | 2011 | 21778997 | Yes |
| 2615 | 1314 | 1314.0 | 33.38 | 33.4 | Supported membranes: scientific and practical applications. | E Sackmann | Science | 1996 | 8539599 | No |
| 2616 | 1314 | 1314.0 | 42.0 | 42.0 | How stigma interferes with mental health care. | Patrick Corrigan | Am Psychol | 2004 | 15491256 | Yes |
| 2617 | 2628 | 1314.0 | 57.64 | 28.8 | Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. | S W Hell, J Wichmann | Opt Lett | 1994 | 19844443 | Yes |
| 2618 | 1314 | 1314.0 | 39.23 | 39.2 | Persister cells. | Kim Lewis | Annu Rev Microbiol | 2010 | 20528688 | No |
| 2619 | 7881 | 1313.5 | 196.95 | 32.8 | An obesity-associated gut microbiome with increased capacity for energy harvest. | Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I Gordon | Nature | 2006 | 17183312 | Yes |
| 2620 | 1313 | 1313.0 | 33.65 | 33.6 | Psychological and neural mechanisms of the affective dimension of pain. | D D Price | Science | 2000 | 10846154 | No |
| 2621 | 1313 | 1313.0 | 27.22 | 27.2 | Neuroligins and neurexins link synaptic function to cognitive disease. | Thomas C Südhof | Nature | 2008 | 18923512 | No |
| 2622 | 1312 | 1312.0 | 69.49 | 69.5 | Psychosocial resilience and protective mechanisms. | Michael Rutter | Am J Orthopsychiatry | 1987 | 3303954 | No |
| 2623 | 3935 | 1311.7 | 111.31 | 37.1 | The Patient Health Questionnaire-2: validity of a two-item depression screener. | Kurt Kroenke, Robert L Spitzer, Janet B W Williams | Med Care | 2003 | 14583691 | Yes |
| 2624 | 1311 | 1311.0 | 37.27 | 37.3 | The matrix-degrading metalloproteinases. | L M Matrisian | Bioessays | 1992 | 1445287 | No |
| 2625 | 1311 | 1311.0 | 39.65 | 39.6 | Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. | W W Douglas | Br J Pharmacol | 1968 | 4882190 | No |
| 2626 | 1311 | 1311.0 | 42.17 | 42.2 | An application of prefrontal cortex function theory to cognitive aging. | R L West | Psychol Bull | 1996 | 8831298 | No |
| 2627 | 1311 | 1311.0 | 28.54 | 28.5 | Long-term potentiation and memory. | M A Lynch | Physiol Rev | 2004 | 14715912 | No |
| 2628 | 5243 | 1310.8 | 104.24 | 26.1 | Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. | D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini | Science | 2005 | 15718470 | Yes |
| 2629 | 1310 | 1310.0 | 34.59 | 34.6 | Phylogenies from molecular sequences: inference and reliability. | J Felsenstein | Annu Rev Genet | 1988 | 3071258 | No |
| 2630 | 1310 | 1310.0 | 24.48 | 24.5 | Antigen-specific interaction between T and B cells. | A Lanzavecchia | Nature | 1985 | 3157869 | Yes |
| 2631 | 1310 | 1310.0 | 0.0 | 0.0 | Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. | P F Scholander | J Biol Chem | 1947 | 20281644 | Yes |
| 2632 | 2619 | 1309.5 | 163.17 | 81.6 | Facial nerve grading system. | J W House, D E Brackmann | Otolaryngol Head Neck Surg | 1985 | 3921901 | Yes |
| 2633 | 2618 | 1309.0 | 77.11 | 38.6 | Prediction of the secondary structure of proteins from their amino acid sequence. | P Y Chou, G D Fasman | Adv Enzymol Relat Areas Mol Biol | 1978 | 364941 | No |
| 2634 | 1309 | 1309.0 | 37.27 | 37.3 | Qinghaosu (artemisinin): an antimalarial drug from China. | D L Klayman | Science | 1985 | 3887571 | No |
| 2635 | 2618 | 1309.0 | 40.47 | 20.2 | Functions of lysosomes. | C De Duve, R Wattiaux | Annu Rev Physiol | 1966 | 5322983 | No |
| 2636 | 1309 | 1309.0 | 21.76 | 21.8 | Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. | W D Hamilton | Science | 1967 | 6021675 | Yes |
| 2637 | 2618 | 1309.0 | 47.63 | 23.8 | Immunization of dissociated spleen cell cultures from normal mice. | R I Mishell, R W Dutton | J Exp Med | 1967 | 6034749 | Yes |
| 2638 | 1309 | 1309.0 | 33.01 | 33.0 | Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. | R M Sapolsky | Arch Gen Psychiatry | 2000 | 11015810 | No |
| 2639 | 1309 | 1309.0 | 35.73 | 35.7 | Regulation of glutathione synthesis. | Shelly C Lu | Mol Aspects Med | 2009 | 18601945 | No |
| 2640 | 2617 | 1308.5 | 59.44 | 29.7 | Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. | E Y Chen, P H Seeburg | DNA | 1985 | 3996185 | Yes |
| 2641 | 1308 | 1308.0 | 35.68 | 35.7 | The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. | R G Gerrity | Am J Pathol | 1981 | 7234961 | Yes |
| 2642 | 1308 | 1308.0 | 27.63 | 27.6 | Double identity for proteins of the Bcl-2 family. | J C Reed | Nature | 1997 | 9194558 | No |
| 2643 | 1308 | 1308.0 | 27.68 | 27.7 | Prediction of protein cellular attributes using pseudo-amino acid composition. | K C Chou | Proteins | 2001 | 11288174 | Yes |
| 2644 | 1308 | 1308.0 | 0.0 | 0.0 | Limitations of the application of fourfold table analysis to hospital data. | J Berkson | Biometrics | 1946 | 21001024 | Yes |
| 2645 | 5230 | 1307.5 | 188.52 | 47.1 | Near-optimal probabilistic RNA-seq quantification. | Nicolas L Bray, Harold Pimentel, Páll Melsted, Lior Pachter | Nat Biotechnol | 2016 | 27043002 | Yes |
| 2646 | 2614 | 1307.0 | 38.34 | 19.2 | Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. | J E Sulston, H R Horvitz | Dev Biol | 1977 | 838129 | Yes |
| 2647 | 2614 | 1307.0 | 40.27 | 20.1 | The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. | J Shine, L Dalgarno | Proc Natl Acad Sci U S A | 1974 | 4598299 | Yes |
| 2648 | 1307 | 1307.0 | 0.0 | 0.0 | A quantitative immunochemical measure of the primary interaction between I BSA and antibody. | R S Farr | J Infect Dis | 1958 | 13611294 | Yes |
| 2649 | 2612 | 1306.0 | 0.0 | 0.0 | Construct validity in psychological tests. | L J Cronbach, P E Meehl | Psychol Bull | 1955 | 13245896 | Yes |
| 2650 | 2612 | 1306.0 | 67.52 | 33.8 | Integrins in cancer: biological implications and therapeutic opportunities. | Jay S Desgrosellier, David A Cheresh | Nat Rev Cancer | 2010 | 20029421 | No |
| 2651 | 1306 | 1306.0 | 56.81 | 56.8 | Canadian Diabetes Association 2013 clinical practice guidelines for the prevention and management of diabetes in Canada. Introduction. | Alice Y Y Cheng | Can J Diabetes | 2013 | 24070926 | No |
| 2652 | 1306 | 1306.0 | 41.15 | 41.1 | Function and information content of DNA methylation. | Dirk Schübeler | Nature | 2015 | 25592537 | No |
| 2653 | 3916 | 1305.3 | 91.38 | 30.5 | Evolution and functions of long noncoding RNAs. | Chris P Ponting, Peter L Oliver, Wolf Reik | Cell | 2009 | 19239885 | No |
| 2654 | 1305 | 1305.0 | 31.87 | 31.9 | Surrogate endpoints in clinical trials: definition and operational criteria. | R L Prentice | Stat Med | 1989 | 2727467 | Yes |
| 2655 | 5220 | 1305.0 | 114.56 | 28.6 | A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. | Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry Sharpless | Angew Chem Int Ed Engl | 2002 | 12203546 | Yes |
| 2656 | 1305 | 1305.0 | 32.17 | 32.2 | Overview of general physiologic features and functions of vitamin D. | Hector F DeLuca | Am J Clin Nutr | 2004 | 15585789 | No |
| 2657 | 2610 | 1305.0 | 83.67 | 41.8 | The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. | Julie D Henry, John R Crawford | Br J Clin Psychol | 2005 | 16004657 | Yes |
| 2658 | 1305 | 1305.0 | 105.41 | 105.4 | COVID-19 and African Americans. | Clyde W Yancy | JAMA | 2020 | 32293639 | Yes |
| 2659 | 1304 | 1304.0 | 29.81 | 29.8 | The path to ubiquitous and low-cost organic electronic appliances on plastic. | Stephen R Forrest | Nature | 2004 | 15118718 | Yes |
| 2660 | 6517 | 1303.4 | 159.86 | 32.0 | Enzymatic determination of total serum cholesterol. | C C Allain, L S Poon, C S Chan, W Richmond, P C Fu | Clin Chem | 1974 | 4818200 | Yes |
| 2661 | 1303 | 1303.0 | 81.65 | 81.7 | SARS-CoV-2 vaccines in development. | Florian Krammer | Nature | 2020 | 32967006 | No |
| 2662 | 2605 | 1302.5 | 57.87 | 28.9 | The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. | P M Sharp, W H Li | Nucleic Acids Res | 1987 | 3547335 | Yes |
| 2663 | 2605 | 1302.5 | 60.28 | 30.1 | Quorum sensing in bacteria. | M B Miller, B L Bassler | Annu Rev Microbiol | 2001 | 11544353 | No |
| 2664 | 3906 | 1302.0 | 87.66 | 29.2 | Photodynamic therapy for cancer. | Dennis E J G J Dolmans, Dai Fukumura, Rakesh K Jain | Nat Rev Cancer | 2003 | 12724736 | No |
| 2665 | 1302 | 1302.0 | 24.09 | 24.1 | Mobile elements: drivers of genome evolution. | Haig H Kazazian | Science | 2004 | 15016989 | No |
| 2666 | 2603 | 1301.5 | 43.29 | 21.6 | Genetic transformation of Drosophila with transposable element vectors. | G M Rubin, A C Spradling | Science | 1982 | 6289436 | Yes |
| 2667 | 1301 | 1301.0 | 44.62 | 44.6 | The theoretical bases of indirect calorimetry: a review. | E Ferrannini | Metabolism | 1988 | 3278194 | No |
| 2668 | 7805 | 1300.8 | 258.02 | 43.0 | The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. | Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gøtzsche, Jan P Vandenbroucke | J Clin Epidemiol | 2008 | 18313558 | Yes |
| 2669 | 1300 | 1300.0 | 44.55 | 44.5 | PaDEL-descriptor: an open source software to calculate molecular descriptors and fingerprints. | Chun Wei Yap | J Comput Chem | 2011 | 21425294 | Yes |
| 2670 | 3899 | 1299.7 | 127.44 | 42.5 | Rehospitalizations among patients in the Medicare fee-for-service program. | Stephen F Jencks, Mark V Williams, Eric A Coleman | N Engl J Med | 2009 | 19339721 | Yes |
| 2671 | 1299 | 1299.0 | 28.41 | 28.4 | Liver fibrosis -- from bench to bedside. | Scott L Friedman | J Hepatol | 2003 | 12591185 | No |
| 2672 | 1299 | 1299.0 | 30.06 | 30.1 | Pathways of oxidative damage. | James A Imlay | Annu Rev Microbiol | 2003 | 14527285 | No |
| 2673 | 1299 | 1299.0 | 27.59 | 27.6 | Sustainable hydrogen production. | John A Turner | Science | 2004 | 15310892 | Yes |
| 2674 | 1299 | 1299.0 | 30.3 | 30.3 | Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. | Hiroshi Takayanagi | Nat Rev Immunol | 2007 | 17380158 | No |
| 2675 | 1298 | 1298.0 | 35.29 | 35.3 | Neural simulation of action: a unifying mechanism for motor cognition. | M Jeannerod | Neuroimage | 2001 | 11373140 | No |
| 2676 | 2596 | 1298.0 | 0.0 | 0.0 | Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. | H A Edmondson, P E Steiner | Cancer | 1954 | 13160935 | Yes |
| 2677 | 1298 | 1298.0 | 32.89 | 32.9 | Pain and emotion interactions in subregions of the cingulate gyrus. | Brent A Vogt | Nat Rev Neurosci | 2005 | 15995724 | No |
| 2678 | 1298 | 1298.0 | 0.0 | 0.0 | On the local reactions of the arterial wall to changes of internal pressure. | W M Bayliss | J Physiol | 1902 | 16992618 | Yes |
| 2679 | 2595 | 1297.5 | 82.63 | 41.3 | Epidermal growth factor. | G Carpenter, S Cohen | Annu Rev Biochem | 1979 | 382984 | No |
| 2680 | 2595 | 1297.5 | 67.74 | 33.9 | Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis). | S M Rogers, L Bernatchez | Mol Ecol | 2005 | 15660930 | Yes |
| 2681 | 2594 | 1297.0 | 64.46 | 32.2 | Interneurons of the hippocampus. | T F Freund, G Buzsáki | Hippocampus | 1996 | 8915675 | No |
| 2682 | 1297 | 1297.0 | 37.82 | 37.8 | Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. | Louis B Rice | J Infect Dis | 2008 | 18419525 | No |
| 2683 | 1297 | 1297.0 | 111.64 | 111.6 | The STROBE guidelines. | Sarah Cuschieri | Saudi J Anaesth | 2019 | 30930717 | No |
| 2684 | 1296 | 1296.0 | 30.98 | 31.0 | Receptors for epidermal growth factor and other polypeptide mitogens. | G Carpenter | Annu Rev Biochem | 1987 | 3039909 | No |
| 2685 | 1296 | 1296.0 | 36.36 | 36.4 | A Wilcoxon-type test for trend. | J Cuzick | Stat Med | 1985 | 3992076 | Yes |
| 2686 | 1296 | 1296.0 | 29.56 | 29.6 | Oxyradicals and DNA damage. | L J Marnett | Carcinogenesis | 2000 | 10688856 | No |
| 2687 | 1296 | 1296.0 | 39.17 | 39.2 | Understanding diagnostic tests 3: Receiver operating characteristic curves. | Anthony K Akobeng | Acta Paediatr | 2007 | 17376185 | No |
| 2688 | 2591 | 1295.5 | 61.67 | 30.8 | Multipoint quantitative-trait linkage analysis in general pedigrees. | L Almasy, J Blangero | Am J Hum Genet | 1998 | 9545414 | Yes |
| 2689 | 5182 | 1295.5 | 185.67 | 46.4 | The chemistry and applications of metal-organic frameworks. | Hiroyasu Furukawa, Kyle E Cordova, Michael O'Keeffe, Omar M Yaghi | Science | 2013 | 23990564 | Yes |
| 2690 | 1295 | 1295.0 | 29.54 | 29.5 | The prefrontal cortex and cognitive control. | E K Miller | Nat Rev Neurosci | 2000 | 11252769 | No |
| 2691 | 1295 | 1295.0 | 35.78 | 35.8 | T follicular helper cell differentiation, function, and roles in disease. | Shane Crotty | Immunity | 2014 | 25367570 | No |
| 2692 | 1294 | 1294.0 | 31.13 | 31.1 | Papillomavirus infections--a major cause of human cancers. | H zur Hausen | Biochim Biophys Acta | 1996 | 8876633 | No |
| 2693 | 1294 | 1294.0 | 45.73 | 45.7 | Plasma perspective on strong field multiphoton ionization. | P B Corkum | Phys Rev Lett | 1993 | 10054556 | Yes |
| 2694 | 1294 | 1294.0 | 23.36 | 23.4 | CD95's deadly mission in the immune system. | P H Krammer | Nature | 2000 | 11048730 | No |
| 2695 | 1294 | 1294.0 | 59.96 | 60.0 | When to use the Bonferroni correction. | Richard A Armstrong | Ophthalmic Physiol Opt | 2014 | 24697967 | No |
| 2696 | 2587 | 1293.5 | 130.88 | 65.4 | A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. | M Roland, R Morris | Spine (Phila Pa 1976) | 1983 | 6222486 | Yes |
| 2697 | 2587 | 1293.5 | 58.96 | 29.5 | Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. | Kornelia Polyak, Robert A Weinberg | Nat Rev Cancer | 2009 | 19262571 | No |
| 2698 | 2587 | 1293.5 | 69.34 | 34.7 | Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. | Taro Kawai, Shizuo Akira | Immunity | 2011 | 21616434 | No |
| 2699 | 1293 | 1293.0 | 34.34 | 34.3 | The biochemistry and medical significance of the flavonoids. | Bent H Havsteen | Pharmacol Ther | 2002 | 12453566 | No |
| 2700 | 1293 | 1293.0 | 22.56 | 22.6 | The molecular motor toolbox for intracellular transport. | Ronald D Vale | Cell | 2003 | 12600311 | No |
| 2701 | 1293 | 1293.0 | 29.25 | 29.2 | Refined structure of the nicotinic acetylcholine receptor at 4A resolution. | Nigel Unwin | J Mol Biol | 2005 | 15701510 | Yes |
| 2702 | 1293 | 1293.0 | 26.95 | 26.9 | Recognition and processing of ubiquitin-protein conjugates by the proteasome. | Daniel Finley | Annu Rev Biochem | 2009 | 19489727 | No |
| 2703 | 1292 | 1292.0 | 42.57 | 42.6 | Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. | J H Luft | Anat Rec | 1971 | 4108333 | Yes |
| 2704 | 1292 | 1292.0 | 61.5 | 61.5 | Cardiovascular and renal actions of dopamine: potential clinical applications. | L I Goldberg | Pharmacol Rev | 1972 | 4554480 | No |
| 2705 | 1292 | 1292.0 | 27.07 | 27.1 | The stem-cell niche as an entity of action. | David T Scadden | Nature | 2006 | 16810242 | No |
| 2706 | 2583 | 1291.5 | 55.4 | 27.7 | Mitochondrial control of cell death. | G Kroemer, J C Reed | Nat Med | 2000 | 10802706 | No |
| 2707 | 6456 | 1291.2 | 155.5 | 31.1 | Jalview Version 2--a multiple sequence alignment editor and analysis workbench. | Andrew M Waterhouse, James B Procter, David M A Martin, Michèle Clamp, Geoffrey J Barton | Bioinformatics | 2009 | 19151095 | Yes |
| 2708 | 1291 | 1291.0 | 42.22 | 42.2 | Electrophoretic separation of plasma lipoproteins in agarose gel. | R P Noble | J Lipid Res | 1968 | 4176473 | Yes |
| 2709 | 2582 | 1291.0 | 71.25 | 35.6 | What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? | K C Berridge, T E Robinson | Brain Res Brain Res Rev | 1998 | 9858756 | No |
| 2710 | 3871 | 1290.3 | 97.18 | 32.4 | Atomic force microscope. | G Binnig, C F Quate, C Gerber | Phys Rev Lett | 1986 | 10033323 | Yes |
| 2711 | 1290 | 1290.0 | 35.53 | 35.5 | Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. | P Vestergaard | Osteoporos Int | 2007 | 17068657 | No |
| 2712 | 6450 | 1290.0 | 249.68 | 49.9 | The Phyre2 web portal for protein modeling, prediction and analysis. | Lawrence A Kelley, Stefans Mezulis, Christopher M Yates, Mark N Wass, Michael J E Sternberg | Nat Protoc | 2015 | 25950237 | Yes |
| 2713 | 1290 | 1290.0 | 77.84 | 77.8 | Information bias in health research: definition, pitfalls, and adjustment methods. | Alaa Althubaiti | J Multidiscip Healthc | 2016 | 27217764 | No |
| 2714 | 1289 | 1289.0 | 37.28 | 37.3 | Species concepts and species delimitation. | Kevin De Queiroz | Syst Biol | 2007 | 18027281 | Yes |
| 2715 | 1289 | 1289.0 | 53.47 | 53.5 | Inflammation, metaflammation and immunometabolic disorders. | Gökhan S Hotamisligil | Nature | 2017 | 28179656 | No |
| 2716 | 14170 | 1288.2 | 381.07 | 34.6 | The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. | Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J Roccella | JAMA | 2003 | 12748199 | No |
| 2717 | 1288 | 1288.0 | 43.45 | 43.5 | Density matrix formulation for quantum renormalization groups. | S R White | Phys Rev Lett | 1992 | 10046608 | Yes |
| 2718 | 2576 | 1288.0 | 94.4 | 47.2 | Liposomal drug delivery systems: from concept to clinical applications. | Theresa M Allen, Pieter R Cullis | Adv Drug Deliv Rev | 2013 | 23036225 | No |
| 2719 | 2575 | 1287.5 | 45.88 | 22.9 | DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. | Christopher J Bakkenist, Michael B Kastan | Nature | 2003 | 12556884 | Yes |
| 2720 | 1287 | 1287.0 | 31.71 | 31.7 | The mitochondrial electron transport and oxidative phosphorylation system. | Y Hatefi | Annu Rev Biochem | 1985 | 2862839 | No |
| 2721 | 1287 | 1287.0 | 32.04 | 32.0 | TNF-mediated inflammatory disease. | J R Bradley | J Pathol | 2008 | 18161752 | No |
| 2722 | 2573 | 1286.5 | 87.99 | 44.0 | Regulatory sequences involved in the promotion and termination of RNA transcription. | M Rosenberg, D Court | Annu Rev Genet | 1979 | 94251 | No |
| 2723 | 1286 | 1286.0 | 38.93 | 38.9 | Diversity and ubiquity of K channels. | B Rudy | Neuroscience | 1988 | 2457185 | No |
| 2724 | 1286 | 1286.0 | 37.06 | 37.1 | Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. | A Böyum | Scand J Clin Lab Invest Suppl | 1968 | 4179066 | Yes |
| 2725 | 1286 | 1286.0 | 10.68 | 10.7 | Metabolic stability and epigenesis in randomly constructed genetic nets. | S A Kauffman | J Theor Biol | 1969 | 5803332 | Yes |
| 2726 | 1286 | 1286.0 | 46.96 | 47.0 | Substance P. | B Pernow | Pharmacol Rev | 1983 | 6196797 | No |
| 2727 | 2572 | 1286.0 | 97.85 | 48.9 | Cronbach's alpha. | J M Bland, D G Altman | BMJ | 1997 | 9055718 | Yes |
| 2728 | 1286 | 1286.0 | 42.84 | 42.8 | Enhancing the quality and credibility of qualitative analysis. | M Q Patton | Health Serv Res | 1999 | 10591279 | No |
| 2729 | 2572 | 1286.0 | 63.52 | 31.8 | Neuronal plasticity: increasing the gain in pain. | C J Woolf, M W Salter | Science | 2000 | 10846153 | No |
| 2730 | 3858 | 1286.0 | 143.23 | 47.7 | Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis. | Christopher K Prier, Danica A Rankic, David W C MacMillan | Chem Rev | 2013 | 23509883 | No |
| 2731 | 14144 | 1285.8 | 362.74 | 33.0 | Frailty in older adults: evidence for a phenotype. | L P Fried, C M Tangen, J Walston, A B Newman, C Hirsch, J Gottdiener, T Seeman, R Tracy, W J Kop, G Burke, M A McBurnie | J Gerontol A Biol Sci Med Sci | 2001 | 11253156 | Yes |
| 2732 | 2570 | 1285.0 | 89.21 | 44.6 | Surgical risk as related to time of intervention in the repair of intracranial aneurysms. | W E Hunt, R M Hess | J Neurosurg | 1968 | 5635959 | Yes |
| 2733 | 2570 | 1285.0 | 46.61 | 23.3 | Live or let die: the cell's response to p53. | Karen H Vousden, Xin Lu | Nat Rev Cancer | 2002 | 12154352 | No |
| 2734 | 2570 | 1285.0 | 51.99 | 26.0 | Tumorigenesis and the angiogenic switch. | Gabriele Bergers, Laura E Benjamin | Nat Rev Cancer | 2003 | 12778130 | No |
| 2735 | 1284 | 1284.0 | 30.37 | 30.4 | Lymphokine production by human T cells in disease states. | S Romagnani | Annu Rev Immunol | 1994 | 8011282 | No |
| 2736 | 1283 | 1283.0 | 34.6 | 34.6 | How brains beware: neural mechanisms of emotional attention. | Patrik Vuilleumier | Trends Cogn Sci | 2005 | 16289871 | Yes |
| 2737 | 2565 | 1282.5 | 54.68 | 27.3 | The pathophysiology of mitochondrial cell death. | Douglas R Green, Guido Kroemer | Science | 2004 | 15286356 | No |
| 2738 | 2564 | 1282.0 | 86.27 | 43.1 | Factors affecting wound healing. | S Guo, L A Dipietro | J Dent Res | 2010 | 20139336 | No |
| 2739 | 2563 | 1281.5 | 60.74 | 30.4 | Production of single-stranded plasmid DNA. | J Vieira, J Messing | Methods Enzymol | 1987 | 3323803 | Yes |
| 2740 | 2562 | 1281.0 | 221.2 | 110.6 | Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. | R B Gustilo, J T Anderson | J Bone Joint Surg Am | 1976 | 773941 | Yes |
| 2741 | 1281 | 1281.0 | 60.83 | 60.8 | New norms of upper limb fat and muscle areas for assessment of nutritional status. | A R Frisancho | Am J Clin Nutr | 1981 | 6975564 | Yes |
| 2742 | 1281 | 1281.0 | 21.74 | 21.7 | Cancer susceptibility and the functions of BRCA1 and BRCA2. | Ashok R Venkitaraman | Cell | 2002 | 11832208 | No |
| 2743 | 1281 | 1281.0 | 33.48 | 33.5 | Persister cells, dormancy and infectious disease. | Kim Lewis | Nat Rev Microbiol | 2007 | 17143318 | No |
| 2744 | 1281 | 1281.0 | 41.17 | 41.2 | Photoplethysmography and its application in clinical physiological measurement. | John Allen | Physiol Meas | 2007 | 17322588 | No |
| 2745 | 1281 | 1281.0 | 23.92 | 23.9 | ChIP-seq: advantages and challenges of a maturing technology. | Peter J Park | Nat Rev Genet | 2009 | 19736561 | No |
| 2746 | 1281 | 1281.0 | 36.01 | 36.0 | Deconvoluting the context-dependent role for autophagy in cancer. | Eileen White | Nat Rev Cancer | 2012 | 22534666 | No |
| 2747 | 8965 | 1280.7 | 251.58 | 35.9 | Cancer statistics, 2008. | Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J Thun | CA Cancer J Clin | 2008 | 18287387 | Yes |
| 2748 | 6403 | 1280.6 | 239.38 | 47.9 | DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates. | O Folmer, M Black, W Hoeh, R Lutz, R Vrijenhoek | Mol Mar Biol Biotechnol | 1994 | 7881515 | Yes |
| 2749 | 2561 | 1280.5 | 65.54 | 32.8 | Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. | J A Ledbetter, L A Herzenberg | Immunol Rev | 1979 | 398327 | No |
| 2750 | 3840 | 1280.0 | 171.72 | 57.2 | In search of how people change. Applications to addictive behaviors. | J O Prochaska, C C DiClemente, J C Norcross | Am Psychol | 1992 | 1329589 | Yes |
| 2751 | 1280 | 1280.0 | 31.67 | 31.7 | Optimal experimental design for event-related fMRI. | A M Dale | Hum Brain Mapp | 1999 | 10524601 | Yes |
| 2752 | 2560 | 1280.0 | 79.29 | 39.6 | Modeling and comparison of dissolution profiles. | P Costa, J M Sousa Lobo | Eur J Pharm Sci | 2001 | 11297896 | No |
| 2753 | 3839 | 1279.7 | 90.92 | 30.3 | Dystrophin: the protein product of the Duchenne muscular dystrophy locus. | E P Hoffman, R H Brown, L M Kunkel | Cell | 1987 | 3319190 | Yes |
| 2754 | 6398 | 1279.6 | 253.93 | 50.8 | Integrating single-cell transcriptomic data across different conditions, technologies, and species. | Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi, Rahul Satija | Nat Biotechnol | 2018 | 29608179 | Yes |
| 2755 | 1279 | 1279.0 | 28.97 | 29.0 | Chemistry and biology of the immunophilins and their immunosuppressive ligands. | S L Schreiber | Science | 1991 | 1702904 | No |
| 2756 | 1279 | 1279.0 | 56.01 | 56.0 | Biomaterial-centered infection: microbial adhesion versus tissue integration. | A G Gristina | Science | 1987 | 3629258 | Yes |
| 2757 | 1279 | 1279.0 | 26.78 | 26.8 | Nucleic acid junctions and lattices. | N C Seeman | J Theor Biol | 1982 | 6188926 | Yes |
| 2758 | 2558 | 1279.0 | 52.53 | 26.3 | The molecular biology of axon guidance. | M Tessier-Lavigne, C S Goodman | Science | 1996 | 8895455 | No |
| 2759 | 3837 | 1279.0 | 73.91 | 24.6 | Exosomes: composition, biogenesis and function. | Clotilde Théry, Laurence Zitvogel, Sebastian Amigorena | Nat Rev Immunol | 2002 | 12154376 | No |
| 2760 | 1279 | 1279.0 | 0.0 | 0.0 | Agammaglobulinemia. | O C Bruton | Pediatrics | 1952 | 14929630 | Yes |
| 2761 | 1279 | 1279.0 | 31.29 | 31.3 | Hydrogen sulphide and its therapeutic potential. | Csaba Szabó | Nat Rev Drug Discov | 2007 | 17948022 | No |
| 2762 | 1278 | 1278.0 | 42.43 | 42.4 | Bee and wasp venoms. | E Habermann | Science | 1972 | 4113805 | No |
| 2763 | 2555 | 1277.5 | 81.83 | 40.9 | Oxidative mechanisms in the toxicity of metal ions. | S J Stohs, D Bagchi | Free Radic Biol Med | 1995 | 7744317 | No |
| 2764 | 2554 | 1277.0 | 62.71 | 31.4 | The free radical theory of aging matures. | K B Beckman, B N Ames | Physiol Rev | 1998 | 9562038 | No |
| 2765 | 1277 | 1277.0 | 32.01 | 32.0 | Plasmonics: merging photonics and electronics at nanoscale dimensions. | Ekmel Ozbay | Science | 2006 | 16410515 | Yes |
| 2766 | 2553 | 1276.5 | 156.45 | 78.2 | A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. | E S Grood, W J Suntay | J Biomech Eng | 1983 | 6865355 | Yes |
| 2767 | 2553 | 1276.5 | 99.0 | 49.5 | Unique features of long non-coding RNA biogenesis and function. | Jeffrey J Quinn, Howard Y Chang | Nat Rev Genet | 2016 | 26666209 | No |
| 2768 | 1276 | 1276.0 | 39.5 | 39.5 | Somatostatin. | S Reichlin | N Engl J Med | 1983 | 6139753 | No |
| 2769 | 1276 | 1276.0 | 34.56 | 34.6 | Internal models for motor control and trajectory planning. | M Kawato | Curr Opin Neurobiol | 1999 | 10607637 | No |
| 2770 | 1276 | 1276.0 | 36.22 | 36.2 | Plant productivity and environment. | J S Boyer | Science | 1982 | 17808529 | Yes |
| 2771 | 2551 | 1275.5 | 66.92 | 33.5 | Epidemiology and outcomes of osteoporotic fractures. | Steven R Cummings, L Joseph Melton | Lancet | 2002 | 12049882 | No |
| 2772 | 1275 | 1275.0 | 0.0 | 0.0 | Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. | H M Kalckar | J Biol Chem | 1947 | 20285041 | Yes |
| 2773 | 2549 | 1274.5 | 23.61 | 11.8 | Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. | J Altman, G D Das | J Comp Neurol | 1965 | 5861717 | Yes |
| 2774 | 2548 | 1274.0 | 48.93 | 24.5 | Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. | M Fried, D M Crothers | Nucleic Acids Res | 1981 | 6275366 | Yes |
| 2775 | 1274 | 1274.0 | 47.37 | 47.4 | Glutathione synthesis. | Shelly C Lu | Biochim Biophys Acta | 2013 | 22995213 | No |
| 2776 | 2547 | 1273.5 | 67.61 | 33.8 | Establishment and characterization of a human histiocytic lymphoma cell line (U-937). | C Sundström, K Nilsson | Int J Cancer | 1976 | 178611 | Yes |
| 2777 | 2547 | 1273.5 | 61.24 | 30.6 | Drug delivery systems: entering the mainstream. | Theresa M Allen, Pieter R Cullis | Science | 2004 | 15031496 | Yes |
| 2778 | 1273 | 1273.0 | 28.68 | 28.7 | Evaluating medication effects outside of clinical trials: new-user designs. | Wayne A Ray | Am J Epidemiol | 2003 | 14585769 | Yes |
| 2779 | 1273 | 1273.0 | 0.0 | 0.0 | The antidiuretic hormone and the factors which determine its release. | E B Verney | Proc R Soc Lond B Biol Sci | 1947 | 18918876 | Yes |
| 2780 | 2545 | 1272.5 | 64.23 | 32.1 | An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. | Gary Aston-Jones, Jonathan D Cohen | Annu Rev Neurosci | 2005 | 16022602 | No |
| 2781 | 1272 | 1272.0 | 33.18 | 33.2 | Bacteroides: the good, the bad, and the nitty-gritty. | Hannah M Wexler | Clin Microbiol Rev | 2007 | 17934076 | No |
| 2782 | 2543 | 1271.5 | 49.03 | 24.5 | CpG islands in vertebrate genomes. | M Gardiner-Garden, M Frommer | J Mol Biol | 1987 | 3656447 | Yes |
| 2783 | 3814 | 1271.3 | 112.97 | 37.7 | Health benefits of physical activity: the evidence. | Darren E R Warburton, Crystal Whitney Nicol, Shannon S D Bredin | CMAJ | 2006 | 16534088 | No |
| 2784 | 1271 | 1271.0 | 31.56 | 31.6 | Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. | J Deisenhofer | Biochemistry | 1981 | 7236608 | Yes |
| 2785 | 1271 | 1271.0 | 46.15 | 46.1 | Energy metabolism in the liver. | Liangyou Rui | Compr Physiol | 2014 | 24692138 | No |
| 2786 | 2541 | 1270.5 | 76.03 | 38.0 | An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. | Sun Ho Kim, Jin Mo Chung | Pain | 1992 | 1333581 | Yes |
| 2787 | 1270 | 1270.0 | 31.56 | 31.6 | The effective period of preventive antibiotic action in experimental incisions and dermal lesions. | J F Burke | Surgery | 1961 | 16722001 | Yes |
| 2788 | 2539 | 1269.5 | 50.44 | 25.2 | A rapid, sensitive, and specific method for the determination of protein in dilute solution. | W Schaffner, C Weissmann | Anal Biochem | 1973 | 4128882 | Yes |
| 2789 | 1269 | 1269.0 | 46.4 | 46.4 | Experience from a multicentre stroke register: a preliminary report. | S Hatano | Bull World Health Organ | 1976 | 1088404 | Yes |
| 2790 | 1269 | 1269.0 | 25.48 | 25.5 | Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. | R H Schwartz | Cell | 1992 | 1335362 | No |
| 2791 | 3807 | 1269.0 | 103.6 | 34.5 | Molecular characterization of a peripheral receptor for cannabinoids. | S Munro, K L Thomas, M Abu-Shaar | Nature | 1993 | 7689702 | Yes |
| 2792 | 1269 | 1269.0 | 32.18 | 32.2 | Rapid evolution of a protein in vitro by DNA shuffling. | W P Stemmer | Nature | 1994 | 8047147 | Yes |
| 2793 | 5076 | 1269.0 | 116.76 | 29.2 | Autophagy fights disease through cellular self-digestion. | Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky | Nature | 2008 | 18305538 | No |
| 2794 | 1268 | 1268.0 | 32.44 | 32.4 | Drug delivery and targeting. | R Langer | Nature | 1998 | 9579855 | No |
| 2795 | 1268 | 1268.0 | 30.08 | 30.1 | Somatostatin and its receptor family. | Y C Patel | Front Neuroendocrinol | 1999 | 10433861 | No |
| 2796 | 2536 | 1268.0 | 88.34 | 44.2 | Nitric oxide synthases: regulation and function. | Ulrich Förstermann, William C Sessa | Eur Heart J | 2012 | 21890489 | No |
| 2797 | 1267 | 1267.0 | 56.05 | 56.0 | The problem with the phrase women and minorities: intersectionality-an important theoretical framework for public health. | Lisa Bowleg | Am J Public Health | 2012 | 22594719 | Yes |
| 2798 | 1266 | 1266.0 | 28.28 | 28.3 | Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. | T A Springer | Annu Rev Physiol | 1995 | 7778885 | No |
| 2799 | 2532 | 1266.0 | 51.04 | 25.5 | ERBB receptors and cancer: the complexity of targeted inhibitors. | Nancy E Hynes, Heidi A Lane | Nat Rev Cancer | 2005 | 15864276 | No |
| 2800 | 2531 | 1265.5 | 13.33 | 6.7 | Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. | G J Todaro, H Green | J Cell Biol | 1963 | 13985244 | Yes |
| 2801 | 2531 | 1265.5 | 66.63 | 33.3 | Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. | Ajay Kumar Gupta, Mona Gupta | Biomaterials | 2005 | 15626447 | No |
| 2802 | 8856 | 1265.1 | 304.66 | 43.5 | Metagenomic biomarker discovery and explanation. | Nicola Segata, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis Huttenhower | Genome Biol | 2011 | 21702898 | Yes |
| 2803 | 2530 | 1265.0 | 56.95 | 28.5 | Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. | D A Brown, J K Rose | Cell | 1992 | 1531449 | Yes |
| 2804 | 3795 | 1265.0 | 112.03 | 37.3 | The functional anatomy of basal ganglia disorders. | R L Albin, A B Young, J B Penney | Trends Neurosci | 1989 | 2479133 | No |
| 2805 | 1265 | 1265.0 | 35.69 | 35.7 | Targeting recovery: priorities of the spinal cord-injured population. | Kim D Anderson | J Neurotrauma | 2004 | 15672628 | Yes |
| 2806 | 1265 | 1265.0 | 33.92 | 33.9 | Infection in solid-organ transplant recipients. | Jay A Fishman | N Engl J Med | 2007 | 18094380 | No |
| 2807 | 8853 | 1264.7 | 261.74 | 37.4 | Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. | H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E Marsh | Stroke | 1993 | 7678184 | Yes |
| 2808 | 5057 | 1264.2 | 188.15 | 47.0 | Predicting effective microRNA target sites in mammalian mRNAs. | Vikram Agarwal, George W Bell, Jin-Wu Nam, David P Bartel | Elife | 2015 | 26267216 | Yes |
| 2809 | 2528 | 1264.0 | 44.24 | 22.1 | The DNA damage response: putting checkpoints in perspective. | B B Zhou, S J Elledge | Nature | 2000 | 11100718 | No |
| 2810 | 1264 | 1264.0 | 0.0 | 0.0 | A simple objective technique for measuring flexibility in thinking. | E A Berg | J Gen Psychol | 1948 | 18889466 | Yes |
| 2811 | 7581 | 1263.5 | 217.41 | 36.2 | Free radicals and antioxidants in normal physiological functions and human disease. | Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua Telser | Int J Biochem Cell Biol | 2007 | 16978905 | No |
| 2812 | 2526 | 1263.0 | 67.38 | 33.7 | Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. | J L Weber, P E May | Am J Hum Genet | 1989 | 2916582 | Yes |
| 2813 | 1263 | 1263.0 | 14.07 | 14.1 | A restriction point for control of normal animal cell proliferation. | A B Pardee | Proc Natl Acad Sci U S A | 1974 | 4524638 | Yes |
| 2814 | 1263 | 1263.0 | 63.06 | 63.1 | Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. | Anna Maria Carlsson | Pain | 1983 | 6602967 | Yes |
| 2815 | 3789 | 1263.0 | 118.27 | 39.4 | MR diffusion tensor spectroscopy and imaging. | P J Basser, J Mattiello, D LeBihan | Biophys J | 1994 | 8130344 | Yes |
| 2816 | 1263 | 1263.0 | 29.32 | 29.3 | A likelihood approach to estimating phylogeny from discrete morphological character data. | P O Lewis | Syst Biol | 2001 | 12116640 | Yes |
| 2817 | 1263 | 1263.0 | 26.84 | 26.8 | Hypoxia, HIF1 and glucose metabolism in the solid tumour. | Nicholas C Denko | Nat Rev Cancer | 2008 | 19143055 | No |
| 2818 | 2526 | 1263.0 | 88.62 | 44.3 | Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. | John F Cryan, Timothy G Dinan | Nat Rev Neurosci | 2012 | 22968153 | No |
| 2819 | 1262 | 1262.0 | 49.12 | 49.1 | Geriatric Depression Scale. | J A Yesavage | Psychopharmacol Bull | 1988 | 3249773 | Yes |
| 2820 | 1262 | 1262.0 | 35.05 | 35.0 | The effects of stressful life events on depression. | R C Kessler | Annu Rev Psychol | 1997 | 9046559 | No |
| 2821 | 1262 | 1262.0 | 26.71 | 26.7 | Assortative mixing in networks. | M E J Newman | Phys Rev Lett | 2002 | 12443515 | Yes |
| 2822 | 2524 | 1262.0 | 56.0 | 28.0 | Can the pharmaceutical industry reduce attrition rates? | Ismail Kola, John Landis | Nat Rev Drug Discov | 2004 | 15286737 | No |
| 2823 | 1262 | 1262.0 | 41.96 | 42.0 | Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. | Rui Wang | Physiol Rev | 2012 | 22535897 | No |
| 2824 | 20189 | 1261.8 | 569.11 | 35.6 | New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). | E A Eisenhauer, P Therasse, J Bogaerts, L H Schwartz, D Sargent, R Ford, J Dancey, S Arbuck, S Gwyther, M Mooney, L Rubinstein, L Shankar, L Dodd, R Kaplan, D Lacombe, J Verweij | Eur J Cancer | 2009 | 19097774 | No |
| 2825 | 2523 | 1261.5 | 63.39 | 31.7 | Epidemiology of Parkinson's disease. | Lonneke M L de Lau, Monique M B Breteler | Lancet Neurol | 2006 | 16713924 | No |
| 2826 | 1261 | 1261.0 | 30.41 | 30.4 | Short-term synaptic plasticity. | R S Zucker | Annu Rev Neurosci | 1989 | 2648947 | No |
| 2827 | 1261 | 1261.0 | 25.97 | 26.0 | Signal transduction via the MAP kinases: proceed at your own RSK. | J Blenis | Proc Natl Acad Sci U S A | 1993 | 8392180 | No |
| 2828 | 1261 | 1261.0 | 39.65 | 39.6 | The Danish Register of Causes of Death. | Karin Helweg-Larsen | Scand J Public Health | 2011 | 21775346 | Yes |
| 2829 | 1260 | 1260.0 | 33.86 | 33.9 | Signaling through phosphatidylcholine breakdown. | J H Exton | J Biol Chem | 1990 | 2104616 | No |
| 2830 | 2519 | 1259.5 | 47.15 | 23.6 | The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. | T Maehama, J E Dixon | J Biol Chem | 1998 | 9593664 | Yes |
| 2831 | 3778 | 1259.3 | 89.78 | 29.9 | Thresholding of statistical maps in functional neuroimaging using the false discovery rate. | Christopher R Genovese, Nicole A Lazar, Thomas Nichols | Neuroimage | 2002 | 11906227 | Yes |
| 2832 | 1259 | 1259.0 | 36.1 | 36.1 | Peptide antibiotics and their role in innate immunity. | H G Boman | Annu Rev Immunol | 1995 | 7612236 | No |
| 2833 | 1259 | 1259.0 | 28.63 | 28.6 | Optical microcavities. | Kerry J Vahala | Nature | 2003 | 12917698 | Yes |
| 2834 | 5035 | 1258.8 | 144.16 | 36.0 | Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. | N Weidner, J P Semple, W R Welch, J Folkman | N Engl J Med | 1991 | 1701519 | Yes |
| 2835 | 1258 | 1258.0 | 44.83 | 44.8 | The LMS method for constructing normalized growth standards. | T J Cole | Eur J Clin Nutr | 1990 | 2354692 | Yes |
| 2836 | 1258 | 1258.0 | 25.75 | 25.8 | SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. | S V Evans | J Mol Graph | 1993 | 8347566 | Yes |
| 2837 | 1258 | 1258.0 | 25.69 | 25.7 | Endocytosis and molecular sorting. | I Mellman | Annu Rev Cell Dev Biol | 1996 | 8970738 | No |
| 2838 | 2516 | 1258.0 | 48.79 | 24.4 | Proliferation, cell cycle and apoptosis in cancer. | G I Evan, K H Vousden | Nature | 2001 | 11357141 | No |
| 2839 | 2516 | 1258.0 | 68.78 | 34.4 | The cognitive control of emotion. | Kevin N Ochsner, James J Gross | Trends Cogn Sci | 2005 | 15866151 | No |
| 2840 | 2516 | 1258.0 | 64.28 | 32.1 | Biology of incretins: GLP-1 and GIP. | Laurie L Baggio, Daniel J Drucker | Gastroenterology | 2007 | 17498508 | No |
| 2841 | 2515 | 1257.5 | 73.1 | 36.5 | Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. | J I Morgan, T Curran | Annu Rev Neurosci | 1991 | 1903243 | No |
| 2842 | 1257 | 1257.0 | 42.83 | 42.8 | Inhibition and facilitation of nucleic acid amplification. | I G Wilson | Appl Environ Microbiol | 1997 | 9327537 | No |
| 2843 | 1257 | 1257.0 | 26.64 | 26.6 | Molecular physiology of low-voltage-activated t-type calcium channels. | Edward Perez-Reyes | Physiol Rev | 2003 | 12506128 | No |
| 2844 | 5027 | 1256.8 | 105.06 | 26.3 | Interleukin-10 and the interleukin-10 receptor. | K W Moore, R de Waal Malefyt, R L Coffman, A O'Garra | Annu Rev Immunol | 2001 | 11244051 | No |
| 2845 | 2513 | 1256.5 | 61.7 | 30.9 | Pharmacology and functions of metabotropic glutamate receptors. | P J Conn, J P Pin | Annu Rev Pharmacol Toxicol | 1997 | 9131252 | No |
| 2846 | 1256 | 1256.0 | 0.0 | 0.0 | The relation of the trail making test to organic brain damage. | R M Reitan | J Consult Psychol | 1955 | 13263471 | Yes |
| 2847 | 2512 | 1256.0 | 48.41 | 24.2 | Gene silencing in cancer in association with promoter hypermethylation. | James G Herman, Stephen B Baylin | N Engl J Med | 2003 | 14627790 | No |
| 2848 | 5024 | 1256.0 | 131.38 | 32.8 | Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. | Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S Vasan | Stat Med | 2008 | 17569110 | Yes |
| 2849 | 1256 | 1256.0 | 59.93 | 59.9 | The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease. | Costantino Iadecola | Neuron | 2017 | 28957666 | No |
| 2850 | 1255 | 1255.0 | 30.53 | 30.5 | Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. | P Kuzmic | Anal Biochem | 1996 | 8660575 | Yes |
| 2851 | 3763 | 1254.3 | 184.95 | 61.6 | Assessing coping strategies: a theoretically based approach. | C S Carver, M F Scheier, J K Weintraub | J Pers Soc Psychol | 1989 | 2926629 | Yes |
| 2852 | 1254 | 1254.0 | 82.88 | 82.9 | The problem of rigor in qualitative research. | M Sandelowski | ANS Adv Nurs Sci | 1986 | 3083765 | Yes |
| 2853 | 1254 | 1254.0 | 31.53 | 31.5 | Apoptosis. | J J Cohen | Immunol Today | 1993 | 8466628 | No |
| 2854 | 1254 | 1254.0 | 27.78 | 27.8 | Neurobiology of Pavlovian fear conditioning. | S Maren | Annu Rev Neurosci | 2001 | 11520922 | No |
| 2855 | 1254 | 1254.0 | 20.59 | 20.6 | The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. | G A Rose | Bull World Health Organ | 1962 | 13974778 | Yes |
| 2856 | 1254 | 1254.0 | 25.97 | 26.0 | The roles of intracellular protein-degradation pathways in neurodegeneration. | David C Rubinsztein | Nature | 2006 | 17051204 | No |
| 2857 | 13793 | 1253.9 | 327.36 | 29.8 | New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. | P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G Gwyther | J Natl Cancer Inst | 2000 | 10655437 | No |
| 2858 | 5014 | 1253.5 | 283.17 | 70.8 | Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. | L A Papile, J Burstein, R Burstein, H Koffler | J Pediatr | 1978 | 305471 | Yes |
| 2859 | 3760 | 1253.3 | 112.4 | 37.5 | Oxidants, antioxidants, and the degenerative diseases of aging. | B N Ames, M K Shigenaga, T M Hagen | Proc Natl Acad Sci U S A | 1993 | 8367443 | No |
| 2860 | 1253 | 1253.0 | 34.46 | 34.5 | Tumor angiogenesis. | J Folkman | Adv Cancer Res | 1985 | 2581424 | No |
| 2861 | 1253 | 1253.0 | 32.32 | 32.3 | Strategy and tactics in protein chemistry. | B S Hartley | Biochem J | 1970 | 4923920 | No |
| 2862 | 1253 | 1253.0 | 30.44 | 30.4 | Primate anterior cingulate cortex: where motor control, drive and cognition interface. | T Paus | Nat Rev Neurosci | 2001 | 11389475 | No |
| 2863 | 1253 | 1253.0 | 27.02 | 27.0 | S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. | R Donato | Int J Biochem Cell Biol | 2001 | 11390274 | No |
| 2864 | 1253 | 1253.0 | 32.12 | 32.1 | Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. | Earl S Ford | Diabetes Care | 2005 | 15983333 | No |
| 2865 | 2505 | 1252.5 | 56.14 | 28.1 | Cellular processing of platinum anticancer drugs. | Dong Wang, Stephen J Lippard | Nat Rev Drug Discov | 2005 | 15789122 | No |
| 2866 | 1252 | 1252.0 | 52.48 | 52.5 | A cochlear frequency-position function for several species--29 years later. | D D Greenwood | J Acoust Soc Am | 1990 | 2373794 | Yes |
| 2867 | 1252 | 1252.0 | 42.19 | 42.2 | Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. | R Lotan | Biochim Biophys Acta | 1980 | 6989400 | No |
| 2868 | 1252 | 1252.0 | 45.64 | 45.6 | Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants. | R W Bohannon | Age Ageing | 1997 | 9143432 | Yes |
| 2869 | 1252 | 1252.0 | 24.81 | 24.8 | Searching for genetic determinants in the new millennium. | N J Risch | Nature | 2000 | 10866211 | No |
| 2870 | 1252 | 1252.0 | 29.36 | 29.4 | Reactive oxygen radicals in signaling and damage in the ischemic brain. | P H Chan | J Cereb Blood Flow Metab | 2001 | 11149664 | No |
| 2871 | 1252 | 1252.0 | 30.33 | 30.3 | Electrochemiluminescence (ECL). | Mark M Richter | Chem Rev | 2004 | 15186186 | No |
| 2872 | 1252 | 1252.0 | 39.25 | 39.2 | Tumor delivery of macromolecular drugs based on the EPR effect. | Vladimir Torchilin | Adv Drug Deliv Rev | 2011 | 20304019 | No |
| 2873 | 2503 | 1251.5 | 57.81 | 28.9 | DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. | S Tabor, C C Richardson | Proc Natl Acad Sci U S A | 1987 | 3474623 | Yes |
| 2874 | 2502 | 1251.0 | 66.79 | 33.4 | Increasing incidence of thyroid cancer in the United States, 1973-2002. | Louise Davies, H Gilbert Welch | JAMA | 2006 | 16684987 | Yes |
| 2875 | 1251 | 1251.0 | 50.05 | 50.0 | The variable nature of cognitive control: a dual mechanisms framework. | Todd S Braver | Trends Cogn Sci | 2012 | 22245618 | Yes |
| 2876 | 2501 | 1250.5 | 61.5 | 30.8 | Hydrogels for tissue engineering. | K Y Lee, D J Mooney | Chem Rev | 2001 | 11710233 | No |
| 2877 | 3751 | 1250.3 | 103.71 | 34.6 | Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. | Günter Oberdörster, Eva Oberdörster, Jan Oberdörster | Environ Health Perspect | 2005 | 16002369 | No |
| 2878 | 1250 | 1250.0 | 44.3 | 44.3 | Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. | M A Lemp | CLAO J | 1995 | 8565190 | No |
| 2879 | 2500 | 1250.0 | 53.28 | 26.6 | Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. | Eugenia E Calle, Rudolf Kaaks | Nat Rev Cancer | 2004 | 15286738 | No |
| 2880 | 1250 | 1250.0 | 38.43 | 38.4 | Clinical practice. Endometriosis. | Linda C Giudice | N Engl J Med | 2010 | 20573927 | No |
| 2881 | 2499 | 1249.5 | 49.52 | 24.8 | Of mice and not men: differences between mouse and human immunology. | Javier Mestas, Christopher C W Hughes | J Immunol | 2004 | 14978070 | No |
| 2882 | 3748 | 1249.3 | 87.76 | 29.3 | Global and societal implications of the diabetes epidemic. | P Zimmet, K G Alberti, J Shaw | Nature | 2001 | 11742409 | No |
| 2883 | 1249 | 1249.0 | 57.7 | 57.7 | A cognitive approach to panic. | D M Clark | Behav Res Ther | 1986 | 3741311 | Yes |
| 2884 | 1249 | 1249.0 | 24.54 | 24.5 | Structure and function of intercellular junctions. | L A Staehelin | Int Rev Cytol | 1974 | 4611943 | No |
| 2885 | 1249 | 1249.0 | 0.0 | 0.0 | Intra-sexual selection in Drosophila. | A J Bateman | Heredity (Edinb) | 1948 | 18103134 | Yes |
| 2886 | 9985 | 1248.1 | 254.21 | 31.8 | A method and server for predicting damaging missense mutations. | Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R Sunyaev | Nat Methods | 2010 | 20354512 | Yes |
| 2887 | 1248 | 1248.0 | 20.54 | 20.5 | Antigen receptor tail clue. | M Reth | Nature | 1989 | 2927501 | Yes |
| 2888 | 2496 | 1248.0 | 68.7 | 34.4 | Nitric oxide synthases: roles, tolls, and controls. | C Nathan, Q W Xie | Cell | 1994 | 7522969 | No |
| 2889 | 1248 | 1248.0 | 31.71 | 31.7 | The complex role of estrogens in inflammation. | Rainer H Straub | Endocr Rev | 2007 | 17640948 | No |
| 2890 | 2496 | 1248.0 | 95.24 | 47.6 | Kraken: ultrafast metagenomic sequence classification using exact alignments. | Derrick E Wood, Steven L Salzberg | Genome Biol | 2014 | 24580807 | Yes |
| 2891 | 2496 | 1248.0 | 245.25 | 122.6 | Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. | David J Newman, Gordon M Cragg | J Nat Prod | 2020 | 32162523 | No |
| 2892 | 2495 | 1247.5 | 62.57 | 31.3 | Nanostructures in biodiagnostics. | Nathaniel L Rosi, Chad A Mirkin | Chem Rev | 2005 | 15826019 | No |
| 2893 | 2495 | 1247.5 | 76.14 | 38.1 | bold: The Barcode of Life Data System (http://www.barcodinglife.org). | Sujeevan Ratnasingham, Paul D N Hebert | Mol Ecol Notes | 2007 | 18784790 | Yes |
| 2894 | 1247 | 1247.0 | 33.6 | 33.6 | Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. | U Mitzdorf | Physiol Rev | 1985 | 3880898 | No |
| 2895 | 2494 | 1247.0 | 49.4 | 24.7 | Community structure in social and biological networks. | M Girvan, M E J Newman | Proc Natl Acad Sci U S A | 2002 | 12060727 | No |
| 2896 | 1247 | 1247.0 | 81.25 | 81.2 | Epidemiology of Prostate Cancer. | Prashanth Rawla | World J Oncol | 2019 | 31068988 | No |
| 2897 | 2493 | 1246.5 | 91.17 | 45.6 | The stunned myocardium: prolonged, postischemic ventricular dysfunction. | E Braunwald, R A Kloner | Circulation | 1982 | 6754130 | No |
| 2898 | 2493 | 1246.5 | 64.45 | 32.2 | Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. | Barry J Everitt, Trevor W Robbins | Nat Neurosci | 2005 | 16251991 | No |
| 2899 | 1246 | 1246.0 | 31.43 | 31.4 | Functionalized acenes and heteroacenes for organic electronics. | John E Anthony | Chem Rev | 2006 | 17165682 | Yes |
| 2900 | 7474 | 1245.7 | 207.83 | 34.6 | Genome engineering using the CRISPR-Cas9 system. | F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng Zhang | Nat Protoc | 2013 | 24157548 | Yes |
| 2901 | 1245 | 1245.0 | 22.64 | 22.6 | Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. | P Rakic | J Comp Neurol | 1971 | 4101340 | Yes |
| 2902 | 2489 | 1244.5 | 63.11 | 31.6 | Genetic dissection of complex traits. | E S Lander, N J Schork | Science | 1994 | 8091226 | No |
| 2903 | 2489 | 1244.5 | 43.66 | 21.8 | Stats: transcriptional control and biological impact. | David E Levy, J E Darnell | Nat Rev Mol Cell Biol | 2002 | 12209125 | No |
| 2904 | 4976 | 1244.0 | 158.47 | 39.6 | Validation of a combined comorbidity index. | M Charlson, T P Szatrowski, J Peterson, J Gold | J Clin Epidemiol | 1994 | 7722560 | Yes |
| 2905 | 1244 | 1244.0 | 27.53 | 27.5 | Life, death, and the pursuit of apoptosis. | E White | Genes Dev | 1996 | 8557188 | No |
| 2906 | 1244 | 1244.0 | 32.52 | 32.5 | The lipocalin protein family: structure and function. | D R Flower | Biochem J | 1996 | 8761444 | No |
| 2907 | 1244 | 1244.0 | 35.86 | 35.9 | Invasive aspergillosis. | D W Denning | Clin Infect Dis | 1998 | 9564455 | No |
| 2908 | 3732 | 1244.0 | 114.55 | 38.2 | Evaluating the public health impact of health promotion interventions: the RE-AIM framework. | R E Glasgow, T M Vogt, S M Boles | Am J Public Health | 1999 | 10474547 | No |
| 2909 | 1244 | 1244.0 | 0.0 | 0.0 | A modification of receptor theory. | R P Stephenson | Br J Pharmacol Chemother | 1956 | 13383117 | Yes |
| 2910 | 1244 | 1244.0 | 29.05 | 29.1 | Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. | R Balfour Sartor | Nat Clin Pract Gastroenterol Hepatol | 2006 | 16819502 | No |
| 2911 | 2486 | 1243.0 | 47.79 | 23.9 | Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. | C W Greider, E H Blackburn | Cell | 1985 | 3907856 | Yes |
| 2912 | 1243 | 1243.0 | 30.0 | 30.0 | Measurement of feelings using visual analogue scales. | R C Aitken | Proc R Soc Med | 1969 | 4899510 | No |
| 2913 | 1243 | 1243.0 | 33.0 | 33.0 | Akaike's information criterion in generalized estimating equations. | W Pan | Biometrics | 2001 | 11252586 | Yes |
| 2914 | 1243 | 1243.0 | 0.0 | 0.0 | Sequential tests for the detection of linkage. | N E Morton | Am J Hum Genet | 1955 | 13258560 | Yes |
| 2915 | 1243 | 1243.0 | 45.66 | 45.7 | The evolving concept of health literacy. | Don Nutbeam | Soc Sci Med | 2008 | 18952344 | Yes |
| 2916 | 1242 | 1242.0 | 64.7 | 64.7 | Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. | K Satoh | Clin Chim Acta | 1978 | 719890 | Yes |
| 2917 | 2484 | 1242.0 | 76.56 | 38.3 | Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. | J E Hixson, D T Vernier | J Lipid Res | 1990 | 2341813 | Yes |
| 2918 | 1242 | 1242.0 | 42.08 | 42.1 | How is the level of free arachidonic acid controlled in mammalian cells? | R F Irvine | Biochem J | 1982 | 6810878 | No |
| 2919 | 1242 | 1242.0 | 35.39 | 35.4 | Varieties of impulsivity. | J L Evenden | Psychopharmacology (Berl) | 1999 | 10550486 | No |
| 2920 | 3726 | 1242.0 | 116.91 | 39.0 | Qualitative research in health care. Analysing qualitative data. | C Pope, S Ziebland, N Mays | BMJ | 2000 | 10625273 | No |
| 2921 | 1242 | 1242.0 | 38.31 | 38.3 | Sensorimotor integration in human postural control. | R J Peterka | J Neurophysiol | 2002 | 12205132 | Yes |
| 2922 | 2484 | 1242.0 | 219.56 | 109.8 | The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. | Hussin A Rothan, Siddappa N Byrareddy | J Autoimmun | 2020 | 32113704 | No |
| 2923 | 1241 | 1241.0 | 24.61 | 24.6 | STATs: signal transducers and activators of transcription. | J N Ihle | Cell | 1996 | 8608586 | No |
| 2924 | 1241 | 1241.0 | 29.81 | 29.8 | Plant salt tolerance. | J K Zhu | Trends Plant Sci | 2001 | 11173290 | Yes |
| 2925 | 3723 | 1241.0 | 115.76 | 38.6 | Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. | B K Matuszewski, M L Constanzer, C M Chavez-Eng | Anal Chem | 2003 | 12964746 | Yes |
| 2926 | 2481 | 1240.5 | 57.44 | 28.7 | Peroxisome proliferator-activated receptors: nuclear control of metabolism. | B Desvergne, W Wahli | Endocr Rev | 1999 | 10529898 | No |
| 2927 | 2481 | 1240.5 | 62.99 | 31.5 | Hydrogels for tissue engineering: scaffold design variables and applications. | Jeanie L Drury, David J Mooney | Biomaterials | 2003 | 12922147 | No |
| 2928 | 2480 | 1240.0 | 102.78 | 51.4 | Reading senseless sentences: brain potentials reflect semantic incongruity. | M Kutas, S A Hillyard | Science | 1980 | 7350657 | Yes |
| 2929 | 1240 | 1240.0 | 37.41 | 37.4 | Delirium in older persons. | Sharon K Inouye | N Engl J Med | 2006 | 16540616 | No |
| 2930 | 2479 | 1239.5 | 63.72 | 31.9 | The ubiquitin code. | David Komander, Michael Rape | Annu Rev Biochem | 2012 | 22524316 | No |
| 2931 | 1239 | 1239.0 | 24.31 | 24.3 | Cytokines induce the development of functionally heterogeneous T helper cell subsets. | A O'Garra | Immunity | 1998 | 9529145 | No |
| 2932 | 1239 | 1239.0 | 52.75 | 52.8 | Environmentally induced oxidative stress in aquatic animals. | Volodymyr I Lushchak | Aquat Toxicol | 2011 | 21074869 | No |
| 2933 | 2476 | 1238.0 | 59.36 | 29.7 | Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects. | R P Rao, D H Ballard | Nat Neurosci | 1999 | 10195184 | Yes |
| 2934 | 1238 | 1238.0 | 38.12 | 38.1 | Risk and maintenance factors for eating pathology: a meta-analytic review. | Eric Stice | Psychol Bull | 2002 | 12206196 | No |
| 2935 | 3713 | 1237.7 | 221.6 | 73.9 | Production, use, and fate of all plastics ever made. | Roland Geyer, Jenna R Jambeck, Kara Lavender Law | Sci Adv | 2017 | 28776036 | Yes |
| 2936 | 2475 | 1237.5 | 61.2 | 30.6 | Molecular mechanisms of action of steroid/thyroid receptor superfamily members. | M J Tsai, B W O'Malley | Annu Rev Biochem | 1994 | 7979245 | No |
| 2937 | 2475 | 1237.5 | 53.08 | 26.5 | The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. | B N Ames, D T Dubin | J Biol Chem | 1960 | 13793161 | Yes |
| 2938 | 1237 | 1237.0 | 32.44 | 32.4 | Low density lipoprotein oxidation and its pathobiological significance. | D Steinberg | J Biol Chem | 1997 | 9261091 | No |
| 2939 | 1236 | 1236.0 | 37.2 | 37.2 | Calcium channel modulation by neurotransmitters, enzymes and drugs. | H Reuter | Nature | 1983 | 6131381 | No |
| 2940 | 3708 | 1236.0 | 77.62 | 25.9 | Computer visualization of three-dimensional image data using IMOD. | J R Kremer, D N Mastronarde, J R McIntosh | J Struct Biol | 1996 | 8742726 | Yes |
| 2941 | 1236 | 1236.0 | 27.48 | 27.5 | Brain tumors. | L M DeAngelis | N Engl J Med | 2001 | 11150363 | No |
| 2942 | 1236 | 1236.0 | 30.29 | 30.3 | Automatic quantitation of localized in vivo 1H spectra with LCModel. | S W Provencher | NMR Biomed | 2001 | 11410943 | Yes |
| 2943 | 1236 | 1236.0 | 55.39 | 55.4 | Salience processing and insular cortical function and dysfunction. | Lucina Q Uddin | Nat Rev Neurosci | 2015 | 25406711 | No |
| 2944 | 2470 | 1235.0 | 72.98 | 36.5 | Inflammatory mechanisms in obesity. | Margaret F Gregor, Gökhan S Hotamisligil | Annu Rev Immunol | 2011 | 21219177 | No |
| 2945 | 2469 | 1234.5 | 48.25 | 24.1 | Checkpoints: controls that ensure the order of cell cycle events. | L H Hartwell, T A Weinert | Science | 1989 | 2683079 | No |
| 2946 | 1234 | 1234.0 | 21.82 | 21.8 | Mutation selection and the natural history of cancer. | J Cairns | Nature | 1975 | 1143315 | Yes |
| 2947 | 2468 | 1234.0 | 65.8 | 32.9 | Meeting of minds: the medial frontal cortex and social cognition. | David M Amodio, Chris D Frith | Nat Rev Neurosci | 2006 | 16552413 | No |
| 2948 | 2466 | 1233.0 | 64.79 | 32.4 | A review of central 5-HT receptors and their function. | N M Barnes, T Sharp | Neuropharmacology | 1999 | 10462127 | No |
| 2949 | 1233 | 1233.0 | 26.32 | 26.3 | Microglia as a source and target of cytokines. | Uwe-Karsten Hanisch | Glia | 2002 | 12379902 | No |
| 2950 | 1233 | 1233.0 | 28.7 | 28.7 | Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. | Christopher Paul Wild | Cancer Epidemiol Biomarkers Prev | 2005 | 16103423 | No |
| 2951 | 7393 | 1232.2 | 276.25 | 46.0 | Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. | Laura J Damschroder, David C Aron, Rosalind E Keith, Susan R Kirsh, Jeffery A Alexander, Julie C Lowery | Implement Sci | 2009 | 19664226 | Yes |
| 2952 | 2464 | 1232.0 | 68.31 | 34.2 | Ageing and Parkinson's disease: substantia nigra regional selectivity. | J M Fearnley, A J Lees | Brain | 1991 | 1933245 | Yes |
| 2953 | 1232 | 1232.0 | 38.69 | 38.7 | Antioxidants in human health and disease. | B Halliwell | Annu Rev Nutr | 1996 | 8839918 | No |
| 2954 | 1231 | 1231.0 | 22.62 | 22.6 | Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. | Ricky W Johnstone | Nat Rev Drug Discov | 2002 | 12120280 | No |
| 2955 | 6151 | 1230.2 | 192.36 | 38.5 | Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. | J S Beckman, T W Beckman, J Chen, P A Marshall, B A Freeman | Proc Natl Acad Sci U S A | 1990 | 2154753 | Yes |
| 2956 | 2460 | 1230.0 | 39.53 | 19.8 | A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. | D Tautz, C Pfeifle | Chromosoma | 1989 | 2476281 | Yes |
| 2957 | 1230 | 1230.0 | 28.0 | 28.0 | Oxidative stress in neurodegeneration: cause or consequence? | Julie K Andersen | Nat Med | 2004 | 15298006 | No |
| 2958 | 1230 | 1230.0 | 32.01 | 32.0 | Thermo- and pH-responsive polymers in drug delivery. | Dirk Schmaljohann | Adv Drug Deliv Rev | 2006 | 17125884 | No |
| 2959 | 1230 | 1230.0 | 47.79 | 47.8 | The biology and function of exosomes in cancer. | Raghu Kalluri | J Clin Invest | 2016 | 27035812 | No |
| 2960 | 1229 | 1229.0 | 44.26 | 44.3 | Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. | R M Post | Am J Psychiatry | 1992 | 1353322 | No |
| 2961 | 2458 | 1229.0 | 65.76 | 32.9 | Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. | M A Pfeffer, E Braunwald | Circulation | 1990 | 2138525 | No |
| 2962 | 1229 | 1229.0 | 55.41 | 55.4 | Continuous improvement as an ideal in health care. | D M Berwick | N Engl J Med | 1989 | 2909878 | Yes |
| 2963 | 1228 | 1228.0 | 49.19 | 49.2 | Bone "mass" and the "mechanostat": a proposal. | H M Frost | Anat Rec | 1987 | 3688455 | Yes |
| 2964 | 1228 | 1228.0 | 33.83 | 33.8 | Water as an active constituent in cell biology. | Philip Ball | Chem Rev | 2008 | 18095715 | No |
| 2965 | 1227 | 1227.0 | 22.14 | 22.1 | Kinesin and dynein superfamily proteins and the mechanism of organelle transport. | N Hirokawa | Science | 1998 | 9438838 | No |
| 2966 | 6131 | 1226.2 | 300.49 | 60.1 | Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. | N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W Stitt | J Rheumatol | 1988 | 3068365 | Yes |
| 2967 | 1226 | 1226.0 | 42.15 | 42.1 | Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases. | K Tamura | Mol Biol Evol | 1992 | 1630306 | Yes |
| 2968 | 1226 | 1226.0 | 33.8 | 33.8 | Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. | F Hefti | J Neurosci | 1986 | 3746405 | Yes |
| 2969 | 1226 | 1226.0 | 32.03 | 32.0 | Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. | P O Seglen | Exp Cell Res | 1973 | 4358115 | Yes |
| 2970 | 1226 | 1226.0 | 33.54 | 33.5 | The stress response to trauma and surgery. | J P Desborough | Br J Anaesth | 2000 | 10927999 | No |
| 2971 | 1226 | 1226.0 | 27.6 | 27.6 | Production of recombinant protein therapeutics in cultivated mammalian cells. | Florian M Wurm | Nat Biotechnol | 2004 | 15529164 | No |
| 2972 | 2451 | 1225.5 | 54.26 | 27.1 | Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. | G K McMaster, G G Carmichael | Proc Natl Acad Sci U S A | 1977 | 73185 | Yes |
| 2973 | 2451 | 1225.5 | 98.91 | 49.5 | Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococcus species. | R Vilgalys, M Hester | J Bacteriol | 1990 | 2376561 | Yes |
| 2974 | 1225 | 1225.0 | 24.33 | 24.3 | Basement membranes: structure, assembly and role in tumour angiogenesis. | Raghu Kalluri | Nat Rev Cancer | 2003 | 12778132 | No |
| 2975 | 1225 | 1225.0 | 25.07 | 25.1 | Fibrotic disease and the T(H)1/T(H)2 paradigm. | Thomas A Wynn | Nat Rev Immunol | 2004 | 15286725 | No |
| 2976 | 1225 | 1225.0 | 34.93 | 34.9 | High prevalence of vitamin D inadequacy and implications for health. | Michael F Holick | Mayo Clin Proc | 2006 | 16529140 | No |
| 2977 | 1225 | 1225.0 | 24.04 | 24.0 | Up on the tightrope: natural killer cell activation and inhibition. | Lewis L Lanier | Nat Immunol | 2008 | 18425106 | No |
| 2978 | 1225 | 1225.0 | 45.18 | 45.2 | Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. | George S Bloom | JAMA Neurol | 2014 | 24493463 | No |
| 2979 | 4898 | 1224.5 | 134.97 | 33.7 | AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. | Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan | Nat Cell Biol | 2011 | 21258367 | Yes |
| 2980 | 1224 | 1224.0 | 25.76 | 25.8 | Antigen-presenting function of the macrophage. | E R Unanue | Annu Rev Immunol | 1984 | 6242349 | No |
| 2981 | 1224 | 1224.0 | 20.18 | 20.2 | Mitotic kinases as regulators of cell division and its checkpoints. | E A Nigg | Nat Rev Mol Cell Biol | 2001 | 11413462 | No |
| 2982 | 1224 | 1224.0 | 26.22 | 26.2 | Nuclear factor-kappaB: the enemy within. | Bharat B Aggarwal | Cancer Cell | 2004 | 15380510 | No |
| 2983 | 1224 | 1224.0 | 35.17 | 35.2 | The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. | R G Pertwee | Br J Pharmacol | 2008 | 17828291 | No |
| 2984 | 1224 | 1224.0 | 74.74 | 74.7 | Non-alcoholic fatty liver disease - A global public health perspective. | Zobair M Younossi | J Hepatol | 2019 | 30414863 | No |
| 2985 | 4895 | 1223.8 | 129.45 | 32.4 | Organometal halide perovskites as visible-light sensitizers for photovoltaic cells. | Akihiro Kojima, Kenjiro Teshima, Yasuo Shirai, Tsutomu Miyasaka | J Am Chem Soc | 2009 | 19366264 | Yes |
| 2986 | 2447 | 1223.5 | 57.71 | 28.9 | Principles of bioactive lipid signalling: lessons from sphingolipids. | Yusuf A Hannun, Lina M Obeid | Nat Rev Mol Cell Biol | 2008 | 18216770 | No |
| 2987 | 1223 | 1223.0 | 44.89 | 44.9 | The P300 wave of the human event-related potential. | T W Picton | J Clin Neurophysiol | 1992 | 1464675 | No |
| 2988 | 1223 | 1223.0 | 30.86 | 30.9 | Neural systems for recognizing emotion. | Ralph Adolphs | Curr Opin Neurobiol | 2002 | 12015233 | No |
| 2989 | 11007 | 1223.0 | 279.77 | 31.1 | MolProbity: all-atom structure validation for macromolecular crystallography. | Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C Richardson | Acta Crystallogr D Biol Crystallogr | 2010 | 20057044 | Yes |
| 2990 | 1223 | 1223.0 | 66.92 | 66.9 | Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV. | Douglas A Drossman | Gastroenterology | 2016 | 27144617 | Yes |
| 2991 | 2445 | 1222.5 | 62.61 | 31.3 | Humans integrate visual and haptic information in a statistically optimal fashion. | Marc O Ernst, Martin S Banks | Nature | 2002 | 11807554 | Yes |
| 2992 | 1222 | 1222.0 | 22.22 | 22.2 | Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. | H E Ruley | Nature | 1983 | 6308473 | Yes |
| 2993 | 1222 | 1222.0 | 32.99 | 33.0 | The emotional dog and its rational tail: a social intuitionist approach to moral judgment. | J Haidt | Psychol Rev | 2001 | 11699120 | Yes |
| 2994 | 1222 | 1222.0 | 15.07 | 15.1 | Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. | J M Van Rossum | Arch Int Pharmacodyn Ther | 1963 | 13996119 | Yes |
| 2995 | 1222 | 1222.0 | 24.42 | 24.4 | Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. | Sean B Carroll | Cell | 2008 | 18614008 | Yes |
| 2996 | 1221 | 1221.0 | 20.44 | 20.4 | Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. | J O Holloszy | J Biol Chem | 1967 | 4290225 | Yes |
| 2997 | 1220 | 1220.0 | 25.26 | 25.3 | MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. | R N Germain | Cell | 1994 | 8293464 | No |
| 2998 | 4880 | 1220.0 | 151.96 | 38.0 | Epidemiology and causes of preterm birth. | Robert L Goldenberg, Jennifer F Culhane, Jay D Iams, Roberto Romero | Lancet | 2008 | 18177778 | No |
| 2999 | 2440 | 1220.0 | 67.0 | 33.5 | New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. | Jonathan B Baell, Georgina A Holloway | J Med Chem | 2010 | 20131845 | Yes |
| 3000 | 1220 | 1220.0 | 44.82 | 44.8 | The biogenesis and emerging roles of circular RNAs. | Ling-Ling Chen | Nat Rev Mol Cell Biol | 2016 | 26908011 | Yes |
| 3001 | 1219 | 1219.0 | 28.62 | 28.6 | Growth factors and cancer. | S A Aaronson | Science | 1991 | 1659742 | No |
| 3002 | 1219 | 1219.0 | 26.53 | 26.5 | Heterotrimeric G proteins: organizers of transmembrane signals. | E J Neer | Cell | 1995 | 7834744 | No |
| 3003 | 1219 | 1219.0 | 44.65 | 44.6 | Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. | S H Safe | Crit Rev Toxicol | 1994 | 8037844 | No |
| 3004 | 1219 | 1219.0 | 25.9 | 25.9 | Dendritic cells: unique leukocyte populations which control the primary immune response. | D N Hart | Blood | 1997 | 9345009 | No |
| 3005 | 1219 | 1219.0 | 34.39 | 34.4 | Electrochemical glucose biosensors. | Joseph Wang | Chem Rev | 2008 | 18154363 | No |
| 3006 | 4873 | 1218.2 | 112.99 | 28.2 | Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. | G L Wang, B H Jiang, E A Rue, G L Semenza | Proc Natl Acad Sci U S A | 1995 | 7539918 | Yes |
| 3007 | 1218 | 1218.0 | 42.34 | 42.3 | Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. | A J Alpert | J Chromatogr | 1990 | 2324207 | Yes |
| 3008 | 1218 | 1218.0 | 30.41 | 30.4 | Endothelial-leukocyte adhesion molecules. | M P Bevilacqua | Annu Rev Immunol | 1993 | 8476577 | No |
| 3009 | 1218 | 1218.0 | 30.67 | 30.7 | Polymer conjugates as anticancer nanomedicines. | Ruth Duncan | Nat Rev Cancer | 2006 | 16900224 | No |
| 3010 | 1218 | 1218.0 | 24.21 | 24.2 | Protein tyrosine phosphatases: from genes, to function, to disease. | Nicholas K Tonks | Nat Rev Mol Cell Biol | 2006 | 17057753 | No |
| 3011 | 1218 | 1218.0 | 37.75 | 37.8 | Socioeconomic status and obesity. | Lindsay McLaren | Epidemiol Rev | 2007 | 17478442 | No |
| 3012 | 1217 | 1217.0 | 25.21 | 25.2 | Caspase structure, proteolytic substrates, and function during apoptotic cell death. | D W Nicholson | Cell Death Differ | 1999 | 10578171 | No |
| 3013 | 3651 | 1217.0 | 182.86 | 61.0 | Hepatocellular carcinoma. | Alejandro Forner, María Reig, Jordi Bruix | Lancet | 2018 | 29307467 | No |
| 3014 | 3650 | 1216.7 | 61.21 | 20.4 | A system for stable expression of short interfering RNAs in mammalian cells. | Thijn R Brummelkamp, René Bernards, Reuven Agami | Science | 2002 | 11910072 | Yes |
| 3015 | 1216 | 1216.0 | 29.81 | 29.8 | Molecular genetics of colorectal cancer. | Eric R Fearon | Annu Rev Pathol | 2011 | 21090969 | No |
| 3016 | 2431 | 1215.5 | 25.97 | 13.0 | The Aggregation Of Blood Platelets. | G V Born, M J Cross | J Physiol | 1963 | 14056485 | Yes |
| 3017 | 1215 | 1215.0 | 16.33 | 16.3 | The concept of immunological surveillance. | F M Burnet | Prog Exp Tumor Res | 1970 | 4921480 | No |
| 3018 | 1215 | 1215.0 | 62.24 | 62.2 | Rating scales to assess depression in school-aged children. | M Kovacs | Acta Paedopsychiatr | 1981 | 7025571 | Yes |
| 3019 | 1215 | 1215.0 | 26.39 | 26.4 | An overview of epithelio-mesenchymal transformation. | E D Hay | Acta Anat (Basel) | 1995 | 8714286 | No |
| 3020 | 2430 | 1215.0 | 47.72 | 23.9 | Molecular chaperones in the cytosol: from nascent chain to folded protein. | F Ulrich Hartl, Manajit Hayer-Hartl | Science | 2002 | 11884745 | No |
| 3021 | 2429 | 1214.5 | 74.51 | 37.3 | A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. | A Ennaceur, J Delacour | Behav Brain Res | 1988 | 3228475 | Yes |
| 3022 | 1214 | 1214.0 | 45.5 | 45.5 | A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. | S T Tiffany | Psychol Rev | 1990 | 2186423 | No |
| 3023 | 1214 | 1214.0 | 58.88 | 58.9 | ROC methodology in radiologic imaging. | C E Metz | Invest Radiol | 1986 | 3095258 | No |
| 3024 | 1214 | 1214.0 | 0.0 | 0.0 | Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. | P B Medawar | Br J Exp Pathol | 1948 | 18865105 | Yes |
| 3025 | 1214 | 1214.0 | 51.16 | 51.2 | The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults. | L S Radloff | J Youth Adolesc | 1991 | 24265004 | Yes |
| 3026 | 2428 | 1214.0 | 164.09 | 82.0 | An Overview of Heart Rate Variability Metrics and Norms. | Fred Shaffer, J P Ginsberg | Front Public Health | 2017 | 29034226 | No |
| 3027 | 1213 | 1213.0 | 46.76 | 46.8 | A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading. | Cathy J Price | Neuroimage | 2012 | 22584224 | No |
| 3028 | 7277 | 1212.8 | 134.9 | 22.5 | Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. | S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T Tuschl | Nature | 2001 | 11373684 | Yes |
| 3029 | 1212 | 1212.0 | 29.33 | 29.3 | Bcl-2 initiates a new category of oncogenes: regulators of cell death. | S J Korsmeyer | Blood | 1992 | 1498330 | No |
| 3030 | 1212 | 1212.0 | 25.0 | 25.0 | Platelets in atherothrombosis. | Zaverio M Ruggeri | Nat Med | 2002 | 12411949 | No |
| 3031 | 1212 | 1212.0 | 23.2 | 23.2 | Lipid rafts: elusive or illusive? | Sean Munro | Cell | 2003 | 14622593 | No |
| 3032 | 1212 | 1212.0 | 33.2 | 33.2 | Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. | Antoine Bechara | Nat Neurosci | 2005 | 16251988 | No |
| 3033 | 12116 | 1211.6 | 436.2 | 43.6 | The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. | Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gøtzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David Moher | BMJ | 2009 | 19622552 | No |
| 3034 | 2423 | 1211.5 | 50.31 | 25.2 | Sequence logos: a new way to display consensus sequences. | T D Schneider, R M Stephens | Nucleic Acids Res | 1990 | 2172928 | Yes |
| 3035 | 2423 | 1211.5 | 36.52 | 18.3 | High resolution acrylamide gel electrophoresis of histones. | S Panyim, R Chalkley | Arch Biochem Biophys | 1969 | 5778650 | Yes |
| 3036 | 1211 | 1211.0 | 34.96 | 35.0 | A human model of gastric carcinogenesis. | P Correa | Cancer Res | 1988 | 3288329 | No |
| 3037 | 4844 | 1211.0 | 136.12 | 34.0 | Biological identifications through DNA barcodes. | Paul D N Hebert, Alina Cywinska, Shelley L Ball, Jeremy R deWaard | Proc Biol Sci | 2003 | 12614582 | Yes |
| 3038 | 2422 | 1211.0 | 63.81 | 31.9 | A neurotrophic model for stress-related mood disorders. | Ronald S Duman, Lisa M Monteggia | Biol Psychiatry | 2006 | 16631126 | No |
| 3039 | 2421 | 1210.5 | 85.85 | 42.9 | Severe sepsis and septic shock. | Derek C Angus, Tom van der Poll | N Engl J Med | 2013 | 23984731 | No |
| 3040 | 2420 | 1210.0 | 78.22 | 39.1 | Atomic structure and chemistry of human serum albumin. | X M He, D C Carter | Nature | 1992 | 1630489 | Yes |
| 3041 | 1210 | 1210.0 | 24.95 | 24.9 | Morphogenetic roles of classic cadherins. | M Takeichi | Curr Opin Cell Biol | 1995 | 8573335 | No |
| 3042 | 1210 | 1210.0 | 23.04 | 23.0 | IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. | Yong-Jun Liu | Annu Rev Immunol | 2005 | 15771572 | No |
| 3043 | 1210 | 1210.0 | 31.61 | 31.6 | Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. | Paul Willner | Neuropsychobiology | 2005 | 16037678 | No |
| 3044 | 1210 | 1210.0 | 28.75 | 28.8 | Targeting DNA topoisomerase II in cancer chemotherapy. | John L Nitiss | Nat Rev Cancer | 2009 | 19377506 | No |
| 3045 | 4839 | 1209.8 | 131.49 | 32.9 | Measurement of the elastic properties and intrinsic strength of monolayer graphene. | Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James Hone | Science | 2008 | 18635798 | Yes |
| 3046 | 2419 | 1209.5 | 52.38 | 26.2 | Toll-like receptors in innate immunity. | Kiyoshi Takeda, Shizuo Akira | Int Immunol | 2005 | 15585605 | No |
| 3047 | 3628 | 1209.3 | 85.04 | 28.3 | Prediction of total genetic value using genome-wide dense marker maps. | T H Meuwissen, B J Hayes, M E Goddard | Genetics | 2001 | 11290733 | Yes |
| 3048 | 1209 | 1209.0 | 34.18 | 34.2 | What is synergy? | M C Berenbaum | Pharmacol Rev | 1989 | 2692037 | No |
| 3049 | 1209 | 1209.0 | 48.48 | 48.5 | Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. | E H Beachey | J Infect Dis | 1981 | 7014727 | No |
| 3050 | 1209 | 1209.0 | 37.24 | 37.2 | Peritonectomy procedures. | P H Sugarbaker | Ann Surg | 1995 | 7826158 | Yes |
| 3051 | 1209 | 1209.0 | 23.58 | 23.6 | A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. | Xuemei Chen | Science | 2004 | 12893888 | Yes |
| 3052 | 1209 | 1209.0 | 31.36 | 31.4 | Q-ball imaging. | David S Tuch | Magn Reson Med | 2004 | 15562495 | Yes |
| 3053 | 1209 | 1209.0 | 26.08 | 26.1 | Simple model of spiking neurons. | E M Izhikevich | IEEE Trans Neural Netw | 2003 | 18244602 | Yes |
| 3054 | 2416 | 1208.0 | 59.25 | 29.6 | Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. | M E Feder, G E Hofmann | Annu Rev Physiol | 1999 | 10099689 | No |
| 3055 | 2416 | 1208.0 | 97.52 | 48.8 | Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. | Ian Janssen, Allana G Leblanc | Int J Behav Nutr Phys Act | 2010 | 20459784 | Yes |
| 3056 | 1208 | 1208.0 | 34.39 | 34.4 | MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. | Amy E Pasquinelli | Nat Rev Genet | 2012 | 22411466 | No |
| 3057 | 1207 | 1207.0 | 52.74 | 52.7 | Campylobacter enteritis: a "new" disease. | M B Skirrow | Br Med J | 1977 | 871765 | Yes |
| 3058 | 1207 | 1207.0 | 13.84 | 13.8 | Central dogma of molecular biology. | F Crick | Nature | 1970 | 4913914 | No |
| 3059 | 1207 | 1207.0 | 38.57 | 38.6 | Linkage map of Escherichia coli K-12, edition 7. | B J Bachmann | Microbiol Rev | 1983 | 6348505 | No |
| 3060 | 3621 | 1207.0 | 101.95 | 34.0 | Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. | H King, R E Aubert, W H Herman | Diabetes Care | 1998 | 9727886 | Yes |
| 3061 | 2414 | 1207.0 | 59.75 | 29.9 | Rising incidence of hepatocellular carcinoma in the United States. | H B El-Serag, A C Mason | N Engl J Med | 1999 | 10072408 | Yes |
| 3062 | 1207 | 1207.0 | 32.39 | 32.4 | Core affect and the psychological construction of emotion. | James A Russell | Psychol Rev | 2003 | 12529060 | No |
| 3063 | 1207 | 1207.0 | 39.43 | 39.4 | Starting at the beginning: an introduction to coefficient alpha and internal consistency. | David L Streiner | J Pers Assess | 2003 | 12584072 | Yes |
| 3064 | 1207 | 1207.0 | 45.05 | 45.0 | Myeloid-Derived Suppressor Cells. | Dmitry I Gabrilovich | Cancer Immunol Res | 2017 | 28052991 | No |
| 3065 | 2413 | 1206.5 | 63.05 | 31.5 | Imaging cognition II: An empirical review of 275 PET and fMRI studies. | R Cabeza, L Nyberg | J Cogn Neurosci | 2000 | 10769304 | No |
| 3066 | 1206 | 1206.0 | 35.17 | 35.2 | Analyzing the mosaic structure of genes. | J M Smith | J Mol Evol | 1992 | 1556748 | No |
| 3067 | 1206 | 1206.0 | 40.71 | 40.7 | The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. | N M Kaplan | Arch Intern Med | 1989 | 2662932 | No |
| 3068 | 2412 | 1206.0 | 68.62 | 34.3 | Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. | Xiaobo Chen, Samuel S Mao | Chem Rev | 2007 | 17590053 | Yes |
| 3069 | 1206 | 1206.0 | 33.76 | 33.8 | Atomic layer deposition: an overview. | Steven M George | Chem Rev | 2010 | 19947596 | Yes |
| 3070 | 3617 | 1205.7 | 72.99 | 24.3 | Large-scale analysis of the yeast proteome by multidimensional protein identification technology. | M P Washburn, D Wolters, J R Yates | Nat Biotechnol | 2001 | 11231557 | Yes |
| 3071 | 2410 | 1205.0 | 46.15 | 23.1 | Dynamic instability of microtubule growth. | T Mitchison, M Kirschner | Nature | 1984 | 6504138 | Yes |
| 3072 | 1205 | 1205.0 | 26.66 | 26.7 | Translating cell biology into therapeutic advances in Alzheimer's disease. | D J Selkoe | Nature | 1999 | 10392577 | No |
| 3073 | 1205 | 1205.0 | 0.0 | 0.0 | A production of amino acids under possible primitive earth conditions. | S L Miller | Science | 1953 | 13056598 | Yes |
| 3074 | 1205 | 1205.0 | 57.59 | 57.6 | Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review. | Dariush Mozaffarian | Circulation | 2016 | 26746178 | No |
| 3075 | 2409 | 1204.5 | 64.31 | 32.2 | Leukocyte-endothelial adhesion molecules. | T M Carlos, J M Harlan | Blood | 1994 | 7522621 | No |
| 3076 | 1204 | 1204.0 | 33.48 | 33.5 | Papillary and follicular thyroid carcinoma. | M J Schlumberger | N Engl J Med | 1998 | 9445411 | No |
| 3077 | 3610 | 1203.3 | 89.85 | 29.9 | Use and abuse of HOMA modeling. | Tara M Wallace, Jonathan C Levy, David R Matthews | Diabetes Care | 2004 | 15161807 | No |
| 3078 | 1203 | 1203.0 | 41.28 | 41.3 | Assay of intestinal disaccharidases. | A Dahlqvist | Anal Biochem | 1968 | 5636962 | Yes |
| 3079 | 1203 | 1203.0 | 19.65 | 19.6 | Studies on phosphatidylcholine vesicles. Formation and physical characteristics. | C Huang | Biochemistry | 1969 | 5777332 | Yes |
| 3080 | 1203 | 1203.0 | 28.08 | 28.1 | Intracellular protein topogenesis. | G Blobel | Proc Natl Acad Sci U S A | 1980 | 6929499 | Yes |
| 3081 | 1203 | 1203.0 | 20.78 | 20.8 | Stem cells: units of development, units of regeneration, and units in evolution. | I L Weissman | Cell | 2000 | 10647940 | No |
| 3082 | 2406 | 1203.0 | 49.73 | 24.9 | Atherosclerosis. the road ahead. | C K Glass, J L Witztum | Cell | 2001 | 11239408 | No |
| 3083 | 1203 | 1203.0 | 40.15 | 40.1 | Volumetric modulated arc therapy: IMRT in a single gantry arc. | Karl Otto | Med Phys | 2008 | 18293586 | Yes |
| 3084 | 12021 | 1202.1 | 466.5 | 46.6 | MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space. | Fredrik Ronquist, Maxim Teslenko, Paul van der Mark, Daniel L Ayres, Aaron Darling, Sebastian Höhna, Bret Larget, Liang Liu, Marc A Suchard, John P Huelsenbeck | Syst Biol | 2012 | 22357727 | Yes |
| 3085 | 1202 | 1202.0 | 25.65 | 25.6 | The finer things in X-ray diffraction data collection. | J W Pflugrath | Acta Crystallogr D Biol Crystallogr | 1999 | 10531521 | Yes |
| 3086 | 2404 | 1202.0 | 32.56 | 16.3 | Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. | R R Guillard, J H Ryther | Can J Microbiol | 1962 | 13902807 | Yes |
| 3087 | 1202 | 1202.0 | 25.21 | 25.2 | The advantages and disadvantages of being polyploid. | Luca Comai | Nat Rev Genet | 2005 | 16304599 | No |
| 3088 | 3605 | 1201.7 | 167.07 | 55.7 | Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. | F Guillemin, C Bombardier, D Beaton | J Clin Epidemiol | 1993 | 8263569 | No |
| 3089 | 2403 | 1201.5 | 71.27 | 35.6 | Recent advances in the phencyclidine model of schizophrenia. | D C Javitt, S R Zukin | Am J Psychiatry | 1991 | 1654746 | No |
| 3090 | 2403 | 1201.5 | 62.06 | 31.0 | Statistical tests of neutrality of mutations. | Y X Fu, W H Li | Genetics | 1993 | 8454210 | Yes |
| 3091 | 2403 | 1201.5 | 48.97 | 24.5 | NF-kappaB: linking inflammation and immunity to cancer development and progression. | Michael Karin, Florian R Greten | Nat Rev Immunol | 2005 | 16175180 | No |
| 3092 | 1201 | 1201.0 | 33.03 | 33.0 | Normalization of cell responses in cat striate cortex. | D J Heeger | Vis Neurosci | 1992 | 1504027 | Yes |
| 3093 | 1201 | 1201.0 | 30.3 | 30.3 | Disorders of iron metabolism. | N C Andrews | N Engl J Med | 1999 | 10607817 | No |
| 3094 | 2401 | 1200.5 | 96.58 | 48.3 | The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. | R Näätänen, T Picton | Psychophysiology | 1987 | 3615753 | Yes |
| 3095 | 2401 | 1200.5 | 48.54 | 24.3 | Learning the parts of objects by non-negative matrix factorization. | D D Lee, H S Seung | Nature | 1999 | 10548103 | Yes |
| 3096 | 3601 | 1200.3 | 86.53 | 28.8 | Functional diversity of helper T lymphocytes. | A K Abbas, K M Murphy, A Sher | Nature | 1996 | 8893001 | No |
| 3097 | 3601 | 1200.3 | 73.13 | 24.4 | Toll-like receptors: critical proteins linking innate and acquired immunity. | S Akira, K Takeda, T Kaisho | Nat Immunol | 2001 | 11477402 | No |
| 3098 | 2400 | 1200.0 | 210.79 | 105.4 | Radiological demarcation of cemented sockets in total hip replacement. | J G DeLee, J Charnley | Clin Orthop Relat Res | 1976 | 991504 | Yes |
| 3099 | 1200 | 1200.0 | 31.86 | 31.9 | Autistic disturbances of affective contact. | L Kanner | Acta Paedopsychiatr | 1968 | 4880460 | Yes |
| 3100 | 1200 | 1200.0 | 35.17 | 35.2 | Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. | W Sieghart | Pharmacol Rev | 1995 | 7568326 | No |
| 3101 | 1200 | 1200.0 | 25.97 | 26.0 | How neutrophils kill microbes. | Anthony W Segal | Annu Rev Immunol | 2005 | 15771570 | No |
| 3102 | 1200 | 1200.0 | 42.91 | 42.9 | Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls? | Fay B Horak | Age Ageing | 2006 | 16926210 | No |
| 3103 | 1199 | 1199.0 | 26.98 | 27.0 | Mitochondrial transport of cations: channels, exchangers, and permeability transition. | P Bernardi | Physiol Rev | 1999 | 10508231 | No |
| 3104 | 1199 | 1199.0 | 58.08 | 58.1 | The new statistics: why and how. | Geoff Cumming | Psychol Sci | 2014 | 24220629 | Yes |
| 3105 | 2397 | 1198.5 | 53.0 | 26.5 | Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. | T Hunter, B M Sefton | Proc Natl Acad Sci U S A | 1980 | 6246487 | Yes |
| 3106 | 2396 | 1198.0 | 66.06 | 33.0 | Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. | R G Phillips, J E LeDoux | Behav Neurosci | 1992 | 1590953 | Yes |
| 3107 | 1198 | 1198.0 | 32.9 | 32.9 | Diversity of group types, regulation, and function of phospholipase A2. | E A Dennis | J Biol Chem | 1994 | 8175726 | No |
| 3108 | 4790 | 1197.5 | 130.8 | 32.7 | Toxic potential of materials at the nanolevel. | Andre Nel, Tian Xia, Lutz Mädler, Ning Li | Science | 2006 | 16456071 | No |
| 3109 | 2395 | 1197.5 | 71.39 | 35.7 | Plasmonics for improved photovoltaic devices. | Harry A Atwater, Albert Polman | Nat Mater | 2010 | 20168344 | Yes |
| 3110 | 1197 | 1197.0 | 37.97 | 38.0 | The pathogenesis of sepsis. | R C Bone | Ann Intern Med | 1991 | 1872494 | No |
| 3111 | 1197 | 1197.0 | 29.83 | 29.8 | Hereditary cancer, oncogenes, and antioncogenes. | A G Knudson | Cancer Res | 1985 | 2983882 | Yes |
| 3112 | 1197 | 1197.0 | 74.15 | 74.2 | Impingement lesions. | C S Neer | Clin Orthop Relat Res | 1983 | 6825348 | Yes |
| 3113 | 1197 | 1197.0 | 28.05 | 28.1 | Matrix proteoglycans: from molecular design to cellular function. | R V Iozzo | Annu Rev Biochem | 1998 | 9759499 | No |
| 3114 | 1197 | 1197.0 | 32.09 | 32.1 | Production and scavenging of reactive oxygen species in chloroplasts and their functions. | Kozi Asada | Plant Physiol | 2006 | 16760493 | Yes |
| 3115 | 5984 | 1196.8 | 201.18 | 40.2 | Posttraumatic stress disorder in the National Comorbidity Survey. | R C Kessler, A Sonnega, E Bromet, M Hughes, C B Nelson | Arch Gen Psychiatry | 1995 | 7492257 | Yes |
| 3116 | 2393 | 1196.5 | 85.04 | 42.5 | Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. | A Fabiato, F Fabiato | J Physiol (Paris) | 1979 | 533865 | Yes |
| 3117 | 3589 | 1196.3 | 86.31 | 28.8 | Astrocyte-endothelial interactions at the blood-brain barrier. | N Joan Abbott, Lars Rönnbäck, Elisabeth Hansson | Nat Rev Neurosci | 2006 | 16371949 | No |
| 3118 | 2392 | 1196.0 | 92.98 | 46.5 | A simple method to assess exercise behavior in the community. | G Godin, R J Shephard | Can J Appl Sport Sci | 1985 | 4053261 | Yes |
| 3119 | 1196 | 1196.0 | 30.27 | 30.3 | Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. | G Boden | Diabetes | 1997 | 8971073 | No |
| 3120 | 1196 | 1196.0 | 35.18 | 35.2 | The structure of common mental disorders. | R F Krueger | Arch Gen Psychiatry | 1999 | 10530634 | Yes |
| 3121 | 1196 | 1196.0 | 28.5 | 28.5 | Metabolism and functions of glutathione in brain. | R Dringen | Prog Neurobiol | 2000 | 10880854 | No |
| 3122 | 3587 | 1195.7 | 150.89 | 50.3 | Measurement of health status. Ascertaining the minimal clinically important difference. | R Jaeschke, J Singer, G H Guyatt | Control Clin Trials | 1989 | 2691207 | Yes |
| 3123 | 10759 | 1195.4 | 273.5 | 30.4 | Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. | Cole Trapnell, Brian A Williams, Geo Pertea, Ali Mortazavi, Gordon Kwan, Marijke J van Baren, Steven L Salzberg, Barbara J Wold, Lior Pachter | Nat Biotechnol | 2010 | 20436464 | Yes |
| 3124 | 5975 | 1195.0 | 168.56 | 33.7 | Quantitative assessment of tactile allodynia in the rat paw. | S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L Yaksh | J Neurosci Methods | 1994 | 7990513 | Yes |
| 3125 | 1195 | 1195.0 | 23.57 | 23.6 | Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. | Harold F Dvorak | J Clin Oncol | 2002 | 12409337 | No |
| 3126 | 3585 | 1195.0 | 90.73 | 30.2 | Methods in mammalian autophagy research. | Noboru Mizushima, Tamotsu Yoshimori, Beth Levine | Cell | 2010 | 20144757 | Yes |
| 3127 | 1194 | 1194.0 | 28.47 | 28.5 | Rapid and sensitive sequence comparison with FASTP and FASTA. | W R Pearson | Methods Enzymol | 1990 | 2156132 | Yes |
| 3128 | 1194 | 1194.0 | 36.07 | 36.1 | The mysteries of lipoprotein(a). | G Utermann | Science | 1989 | 2530631 | No |
| 3129 | 1194 | 1194.0 | 28.48 | 28.5 | A tension-based theory of morphogenesis and compact wiring in the central nervous system. | D C Van Essen | Nature | 1997 | 9002514 | Yes |
| 3130 | 1194 | 1194.0 | 28.94 | 28.9 | The neuropathology of schizophrenia. A critical review of the data and their interpretation. | P J Harrison | Brain | 1999 | 10219775 | No |
| 3131 | 1194 | 1194.0 | 59.33 | 59.3 | Patient reported outcome measures could help transform healthcare. | Nick Black | BMJ | 2013 | 23358487 | Yes |
| 3132 | 2387 | 1193.5 | 66.76 | 33.4 | Heterogeneous photocatalyst materials for water splitting. | Akihiko Kudo, Yugo Miseki | Chem Soc Rev | 2009 | 19088977 | Yes |
| 3133 | 2386 | 1193.0 | 114.48 | 57.2 | Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. | S F Dworkin, L LeResche | J Craniomandib Disord | 1992 | 1298767 | No |
| 3134 | 1193 | 1193.0 | 48.79 | 48.8 | Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). | S Safe | Crit Rev Toxicol | 1990 | 2124811 | No |
| 3135 | 1193 | 1193.0 | 25.52 | 25.5 | The myofibroblast in wound healing and fibrocontractive diseases. | G Gabbiani | J Pathol | 2003 | 12845617 | No |
| 3136 | 1193 | 1193.0 | 39.56 | 39.6 | Mediators and mechanisms of change in psychotherapy research. | Alan E Kazdin | Annu Rev Clin Psychol | 2007 | 17716046 | No |
| 3137 | 2385 | 1192.5 | 54.93 | 27.5 | Establishing, maintaining and modifying DNA methylation patterns in plants and animals. | Julie A Law, Steven E Jacobsen | Nat Rev Genet | 2010 | 20142834 | No |
| 3138 | 1191 | 1191.0 | 36.8 | 36.8 | Biosynthesis and metabolism of endothelium-derived nitric oxide. | L J Ignarro | Annu Rev Pharmacol Toxicol | 1990 | 2188578 | No |
| 3139 | 1191 | 1191.0 | 43.15 | 43.1 | The case for motivated reasoning. | Z Kunda | Psychol Bull | 1990 | 2270237 | No |
| 3140 | 1191 | 1191.0 | 28.43 | 28.4 | Correlates of protection induced by vaccination. | Stanley A Plotkin | Clin Vaccine Immunol | 2010 | 20463105 | No |
| 3141 | 2381 | 1190.5 | 76.88 | 38.4 | Physiological parameters in laboratory animals and humans. | B Davies, T Morris | Pharm Res | 1993 | 8378254 | No |
| 3142 | 2381 | 1190.5 | 69.32 | 34.7 | Natural products as sources of new drugs over the last 25 years. | David J Newman, Gordon M Cragg | J Nat Prod | 2007 | 17309302 | No |
| 3143 | 10710 | 1190.0 | 354.12 | 39.3 | A novel potent vasoconstrictor peptide produced by vascular endothelial cells. | M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T Masaki | Nature | 1988 | 2451132 | Yes |
| 3144 | 1190 | 1190.0 | 39.06 | 39.1 | Checklists for improving rigour in qualitative research: a case of the tail wagging the dog? | R S Barbour | BMJ | 2001 | 11337448 | No |
| 3145 | 1190 | 1190.0 | 0.0 | 0.0 | The perceptron: a probabilistic model for information storage and organization in the brain. | F Rosenblatt | Psychol Rev | 1958 | 13602029 | Yes |
| 3146 | 11900 | 1190.0 | 298.73 | 29.9 | Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. | M Dominici, K Le Blanc, I Mueller, I Slaper-Cortenbach, Fc Marini, Ds Krause, Rj Deans, A Keating, Dj Prockop, Em Horwitz | Cytotherapy | 2006 | 16923606 | Yes |
| 3147 | 3570 | 1190.0 | 144.22 | 48.1 | Principles of nanoparticle design for overcoming biological barriers to drug delivery. | Elvin Blanco, Haifa Shen, Mauro Ferrari | Nat Biotechnol | 2015 | 26348965 | Yes |
| 3148 | 4759 | 1189.8 | 137.05 | 34.3 | Place navigation impaired in rats with hippocampal lesions. | R G Morris, P Garrud, J N Rawlins, J O'Keefe | Nature | 1982 | 7088155 | Yes |
| 3149 | 5947 | 1189.4 | 140.27 | 28.1 | Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. | T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L Coffman | J Immunol | 1986 | 2419430 | Yes |
| 3150 | 1189 | 1189.0 | 55.14 | 55.1 | The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. | W G Duncombe | Clin Chim Acta | 1964 | 14122498 | Yes |
| 3151 | 2378 | 1189.0 | 48.54 | 24.3 | The mammalian unfolded protein response. | Martin Schröder, Randal J Kaufman | Annu Rev Biochem | 2005 | 15952902 | No |
| 3152 | 1189 | 1189.0 | 0.0 | 0.0 | Comparing individual means in the analysis of variance. | J W Tukey | Biometrics | 1949 | 18151955 | Yes |
| 3153 | 1189 | 1189.0 | 48.34 | 48.3 | The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. | Natalie A de Morton | Aust J Physiother | 2009 | 19463084 | Yes |
| 3154 | 1188 | 1188.0 | 21.34 | 21.3 | Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. | D Hanahan | Nature | 1985 | 2986015 | Yes |
| 3155 | 2376 | 1188.0 | 102.87 | 51.4 | Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. | P R Hunter, M A Gaston | J Clin Microbiol | 1988 | 3069867 | Yes |
| 3156 | 1188 | 1188.0 | 30.64 | 30.6 | The neurobiology of stress: from serendipity to clinical relevance. | B S McEwen | Brain Res | 2000 | 11119695 | No |
| 3157 | 1188 | 1188.0 | 19.17 | 19.2 | Themes and variations on ubiquitylation. | A M Weissman | Nat Rev Mol Cell Biol | 2001 | 11265246 | No |
| 3158 | 1188 | 1188.0 | 34.06 | 34.1 | Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. | M Leavitt | MedGenMed | 2001 | 11549951 | No |
| 3159 | 1188 | 1188.0 | 24.51 | 24.5 | Microsatellites: simple sequences with complex evolution. | Hans Ellegren | Nat Rev Genet | 2004 | 15153996 | No |
| 3160 | 1188 | 1188.0 | 30.14 | 30.1 | Physiology and pathophysiology of purinergic neurotransmission. | Geoffrey Burnstock | Physiol Rev | 2007 | 17429044 | No |
| 3161 | 2376 | 1188.0 | 52.19 | 26.1 | Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. | Jing Yang, Robert A Weinberg | Dev Cell | 2008 | 18539112 | No |
| 3162 | 2376 | 1188.0 | 94.44 | 47.2 | Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. | Ulrich M Zanger, Matthias Schwab | Pharmacol Ther | 2013 | 23333322 | No |
| 3163 | 2376 | 1188.0 | 99.66 | 49.8 | Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. | Peter C Austin, Elizabeth A Stuart | Stat Med | 2015 | 26238958 | No |
| 3164 | 2375 | 1187.5 | 74.39 | 37.2 | Antiseptics and disinfectants: activity, action, and resistance. | G McDonnell, A D Russell | Clin Microbiol Rev | 1999 | 9880479 | No |
| 3165 | 3562 | 1187.3 | 110.11 | 36.7 | The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. | G Blessed, B E Tomlinson, M Roth | Br J Psychiatry | 1968 | 5662937 | Yes |
| 3166 | 1187 | 1187.0 | 40.53 | 40.5 | An approach for the treatment of penile carcinoma. | R M Cabanas | Cancer | 1977 | 837331 | Yes |
| 3167 | 1187 | 1187.0 | 26.65 | 26.6 | The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. | S J Collins | Blood | 1987 | 3311197 | No |
| 3168 | 1187 | 1187.0 | 52.15 | 52.1 | Presynaptic regulation of the release of catecholamines. | S Z Langer | Pharmacol Rev | 1980 | 6267618 | Yes |
| 3169 | 1187 | 1187.0 | 36.43 | 36.4 | The somatic marker hypothesis and the possible functions of the prefrontal cortex. | A R Damasio | Philos Trans R Soc Lond B Biol Sci | 1996 | 8941953 | No |
| 3170 | 2374 | 1187.0 | 77.77 | 38.9 | Efficacy of the Theory of Planned Behaviour: a meta-analytic review. | C J Armitage, M Conner | Br J Soc Psychol | 2001 | 11795063 | Yes |
| 3171 | 1187 | 1187.0 | 0.0 | 0.0 | Voluntary strength and fatigue. | P A Merton | J Physiol | 1954 | 13152698 | Yes |
| 3172 | 1187 | 1187.0 | 26.96 | 27.0 | Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. | William C Aird | Circ Res | 2007 | 17272818 | No |
| 3173 | 2373 | 1186.5 | 112.22 | 56.1 | Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. | J D Peuler, G A Johnson | Life Sci | 1977 | 904439 | Yes |
| 3174 | 2373 | 1186.5 | 95.39 | 47.7 | Rapid procedure for detection and isolation of large and small plasmids. | C I Kado, S T Liu | J Bacteriol | 1981 | 7009583 | Yes |
| 3175 | 2373 | 1186.5 | 61.69 | 30.8 | Verification of protein structures: patterns of nonbonded atomic interactions. | C Colovos, T O Yeates | Protein Sci | 1993 | 8401235 | Yes |
| 3176 | 2372 | 1186.0 | 53.12 | 26.6 | Adaptive protein evolution at the Adh locus in Drosophila. | J H McDonald, M Kreitman | Nature | 1991 | 1904993 | Yes |
| 3177 | 1186 | 1186.0 | 24.85 | 24.9 | Epstein-Barr virus infection. | J I Cohen | N Engl J Med | 2000 | 10944566 | No |
| 3178 | 3557 | 1185.7 | 121.51 | 40.5 | The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting. | C Kirschbaum, K M Pirke, D H Hellhammer | Neuropsychobiology | 1993 | 8255414 | Yes |
| 3179 | 16587 | 1184.8 | 353.68 | 25.3 | Crystallography & NMR system: A new software suite for macromolecular structure determination. | A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L Warren | Acta Crystallogr D Biol Crystallogr | 1998 | 9757107 | Yes |
| 3180 | 2369 | 1184.5 | 76.9 | 38.5 | Quantitative determination of serum triglycerides by the use of enzymes. | G Bucolo, H David | Clin Chem | 1973 | 4703655 | Yes |
| 3181 | 1184 | 1184.0 | 65.92 | 65.9 | Nontuberculous mycobacteria and associated diseases. | E Wolinsky | Am Rev Respir Dis | 1979 | 369415 | No |
| 3182 | 1184 | 1184.0 | 38.15 | 38.1 | Agents that increase the permeability of the outer membrane. | M Vaara | Microbiol Rev | 1992 | 1406489 | No |
| 3183 | 1184 | 1184.0 | 45.01 | 45.0 | Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. | H V Gelboin | Physiol Rev | 1980 | 7001511 | No |
| 3184 | 3552 | 1184.0 | 72.06 | 24.0 | Cellular survival: a play in three Akts. | S R Datta, A Brunet, M E Greenberg | Genes Dev | 1999 | 10579998 | No |
| 3185 | 1184 | 1184.0 | 22.03 | 22.0 | Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. | G D Winter | Nature | 1962 | 14007593 | Yes |
| 3186 | 2367 | 1183.5 | 50.72 | 25.4 | Blinded by the Light: The Growing Complexity of p53. | Karen H Vousden, Carol Prives | Cell | 2009 | 19410540 | No |
| 3187 | 2367 | 1183.5 | 69.22 | 34.6 | Type 2 diabetes as an inflammatory disease. | Marc Y Donath, Steven E Shoelson | Nat Rev Immunol | 2011 | 21233852 | No |
| 3188 | 3550 | 1183.3 | 115.62 | 38.5 | Hepatocellular carcinoma. | Alejandro Forner, Josep M Llovet, Jordi Bruix | Lancet | 2012 | 22353262 | No |
| 3189 | 1183 | 1183.0 | 35.86 | 35.9 | Platelet-rich plasma: evidence to support its use. | Robert E Marx | J Oral Maxillofac Surg | 2004 | 15085519 | No |
| 3190 | 2365 | 1182.5 | 81.15 | 40.6 | The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. | G P Chrousos, P W Gold | JAMA | 1992 | 1538563 | No |
| 3191 | 2365 | 1182.5 | 73.02 | 36.5 | The reward circuit: linking primate anatomy and human imaging. | Suzanne N Haber, Brian Knutson | Neuropsychopharmacology | 2010 | 19812543 | No |
| 3192 | 5912 | 1182.4 | 192.69 | 38.5 | Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. | D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L Witztum | N Engl J Med | 1989 | 2648148 | No |
| 3193 | 2364 | 1182.0 | 43.55 | 21.8 | Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. | C Li, W H Wong | Proc Natl Acad Sci U S A | 2001 | 11134512 | Yes |
| 3194 | 2364 | 1182.0 | 63.39 | 31.7 | A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions. | Yan Zhao, Donald G Truhlar | J Chem Phys | 2006 | 17129083 | Yes |
| 3195 | 1182 | 1182.0 | 76.06 | 76.1 | Cell death: a review of the major forms of apoptosis, necrosis and autophagy. | Mark S D'Arcy | Cell Biol Int | 2019 | 30958602 | No |
| 3196 | 2363 | 1181.5 | 64.13 | 32.1 | Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. | J A Sterne, M Egger | J Clin Epidemiol | 2001 | 11576817 | Yes |
| 3197 | 4724 | 1181.0 | 105.96 | 26.5 | Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. | J E Walker, M Saraste, M J Runswick, N J Gay | EMBO J | 1982 | 6329717 | Yes |
| 3198 | 3543 | 1181.0 | 104.63 | 34.9 | SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building. | Manolo Gouy, Stéphane Guindon, Olivier Gascuel | Mol Biol Evol | 2010 | 19854763 | Yes |
| 3199 | 1181 | 1181.0 | 49.53 | 49.5 | The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review. | Erik G Willcutt | Neurotherapeutics | 2012 | 22976615 | No |
| 3200 | 3542 | 1180.7 | 92.65 | 30.9 | Matrix metalloproteinases: regulators of the tumor microenvironment. | Kai Kessenbrock, Vicki Plaks, Zena Werb | Cell | 2010 | 20371345 | No |
| 3201 | 1180 | 1180.0 | 26.76 | 26.8 | Hybridization of denatured RNA transferred or dotted nitrocellulose paper. | P S Thomas | Methods Enzymol | 1983 | 6194404 | Yes |
| 3202 | 1180 | 1180.0 | 107.74 | 107.7 | The analysis of errors in orthodontic measurements. | W J Houston | Am J Orthod | 1983 | 6573846 | Yes |
| 3203 | 2360 | 1180.0 | 48.37 | 24.2 | Toll-like receptors in the induction of the innate immune response. | A Aderem, R J Ulevitch | Nature | 2000 | 10963608 | No |
| 3204 | 1180 | 1180.0 | 33.59 | 33.6 | On the law of effect. | R J Herrnstein | J Exp Anal Behav | 1970 | 16811440 | Yes |
| 3205 | 1179 | 1179.0 | 39.01 | 39.0 | Interleukin-1 and the pathogenesis of the acute-phase response. | C A Dinarello | N Engl J Med | 1984 | 6208485 | No |
| 3206 | 1179 | 1179.0 | 0.0 | 0.0 | A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. | M G Buonocore | J Dent Res | 1955 | 13271655 | Yes |
| 3207 | 2358 | 1179.0 | 48.76 | 24.4 | Regulation of translation initiation in eukaryotes: mechanisms and biological targets. | Nahum Sonenberg, Alan G Hinnebusch | Cell | 2009 | 19239892 | No |
| 3208 | 2358 | 1179.0 | 70.16 | 35.1 | Mitochondrial fission, fusion, and stress. | Richard J Youle, Alexander M van der Bliek | Science | 2012 | 22936770 | No |
| 3209 | 3536 | 1178.7 | 90.46 | 30.2 | Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. | C R Woese, O Kandler, M L Wheelis | Proc Natl Acad Sci U S A | 1990 | 2112744 | Yes |
| 3210 | 2357 | 1178.5 | 66.87 | 33.4 | The low-density lipoprotein pathway and its relation to atherosclerosis. | J L Goldstein, M S Brown | Annu Rev Biochem | 1977 | 197883 | No |
| 3211 | 2357 | 1178.5 | 70.14 | 35.1 | Multiple significance tests: the Bonferroni method. | J M Bland, D G Altman | BMJ | 1995 | 7833759 | Yes |
| 3212 | 4714 | 1178.5 | 90.21 | 22.6 | Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. | L Alexopoulou, A C Holt, R Medzhitov, R A Flavell | Nature | 2001 | 11607032 | Yes |
| 3213 | 2356 | 1178.0 | 74.48 | 37.2 | Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. | A Warshel, M Levitt | J Mol Biol | 1976 | 985660 | Yes |
| 3214 | 2356 | 1178.0 | 42.08 | 21.0 | Hedgehog signaling in animal development: paradigms and principles. | P W Ingham, A P McMahon | Genes Dev | 2001 | 11731473 | No |
| 3215 | 2356 | 1178.0 | 53.97 | 27.0 | Regulation of wound healing by growth factors and cytokines. | Sabine Werner, Richard Grose | Physiol Rev | 2003 | 12843410 | No |
| 3216 | 5887 | 1177.4 | 277.42 | 55.5 | CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes. | Donovan H Parks, Michael Imelfort, Connor T Skennerton, Philip Hugenholtz, Gene W Tyson | Genome Res | 2015 | 25977477 | Yes |
| 3217 | 8241 | 1177.3 | 161.5 | 23.1 | Exploration, normalization, and summaries of high density oligonucleotide array probe level data. | Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P Speed | Biostatistics | 2003 | 12925520 | Yes |
| 3218 | 1177 | 1177.0 | 57.48 | 57.5 | The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. | G A Ilizarov | Clin Orthop Relat Res | 1989 | 2910611 | Yes |
| 3219 | 1177 | 1177.0 | 27.57 | 27.6 | The epidemiologic transition. A theory of the epidemiology of population change. | A R Omran | Milbank Mem Fund Q | 1971 | 5155251 | Yes |
| 3220 | 1177 | 1177.0 | 32.42 | 32.4 | The induction of pain: an integrative review. | M J Millan | Prog Neurobiol | 1999 | 9987804 | No |
| 3221 | 1177 | 1177.0 | 17.51 | 17.5 | The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. | R E Hope-Simpson | Proc R Soc Med | 1965 | 14267505 | Yes |
| 3222 | 1177 | 1177.0 | 30.88 | 30.9 | A theory of magnitude: common cortical metrics of time, space and quantity. | Vincent Walsh | Trends Cogn Sci | 2003 | 14585444 | Yes |
| 3223 | 1177 | 1177.0 | 0.0 | 0.0 | Histological demonstration of mucin after periodic acid. | J F A McMANUS | Nature | 1946 | 20995486 | Yes |
| 3224 | 2354 | 1177.0 | 105.95 | 53.0 | Functional Classification and Experimental Dissection of Long Noncoding RNAs. | Florian Kopp, Joshua T Mendell | Cell | 2018 | 29373828 | No |
| 3225 | 1177 | 1177.0 | 129.25 | 129.2 | COVID-19 Vaccine Hesitancy Worldwide: A Concise Systematic Review of Vaccine Acceptance Rates. | Malik Sallam | Vaccines (Basel) | 2021 | 33669441 | No |
| 3226 | 2352 | 1176.0 | 87.4 | 43.7 | Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. | H Esterbauer, K H Cheeseman | Methods Enzymol | 1990 | 2233308 | Yes |
| 3227 | 1176 | 1176.0 | 22.8 | 22.8 | Telomeres and human disease: ageing, cancer and beyond. | Maria A Blasco | Nat Rev Genet | 2005 | 16136653 | No |
| 3228 | 1176 | 1176.0 | 35.81 | 35.8 | A practical solution to the pervasive problems of p values. | Eric-Jan Wagenmakers | Psychon Bull Rev | 2007 | 18087943 | Yes |
| 3229 | 7052 | 1175.3 | 157.04 | 26.2 | Principal components analysis corrects for stratification in genome-wide association studies. | Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David Reich | Nat Genet | 2006 | 16862161 | Yes |
| 3230 | 1175 | 1175.0 | 35.71 | 35.7 | MOPAC: a semiempirical molecular orbital program. | J J Stewart | J Comput Aided Mol Des | 1990 | 2197373 | No |
| 3231 | 1175 | 1175.0 | 54.17 | 54.2 | Preliminary Trial Of Carisoprodol In Multiple Sclerosis. | B Ashworth | Practitioner | 1964 | 14143329 | Yes |
| 3232 | 2350 | 1175.0 | 70.43 | 35.2 | Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. | S Geman, D Geman | IEEE Trans Pattern Anal Mach Intell | 1984 | 22499653 | Yes |
| 3233 | 1175 | 1175.0 | 44.15 | 44.1 | Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. | L Sjöström | J Intern Med | 2013 | 23163728 | No |
| 3234 | 5873 | 1174.6 | 109.32 | 21.9 | The protein kinase complement of the human genome. | G Manning, D B Whyte, R Martinez, T Hunter, S Sudarsanam | Science | 2002 | 12471243 | No |
| 3235 | 2349 | 1174.5 | 54.9 | 27.4 | ZINC--a free database of commercially available compounds for virtual screening. | John J Irwin, Brian K Shoichet | J Chem Inf Model | 2005 | 15667143 | Yes |
| 3236 | 1174 | 1174.0 | 30.81 | 30.8 | Pathogenesis of dengue: challenges to molecular biology. | S B Halstead | Science | 1988 | 3277268 | No |
| 3237 | 1174 | 1174.0 | 34.05 | 34.0 | Determinants of tumor blood flow: a review. | R K Jain | Cancer Res | 1988 | 3282647 | No |
| 3238 | 1174 | 1174.0 | 25.14 | 25.1 | Serine protease mechanism and specificity. | Lizbeth Hedstrom | Chem Rev | 2002 | 12475199 | No |
| 3239 | 2348 | 1174.0 | 55.07 | 27.5 | Endometriosis. | Linda C Giudice, Lee C Kao | Lancet | 2004 | 15541453 | No |
| 3240 | 2347 | 1173.5 | 53.32 | 26.7 | Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. | Josep M Llovet, Jordi Bruix | Hepatology | 2003 | 12540794 | No |
| 3241 | 1173 | 1173.0 | 30.66 | 30.7 | Epidemiology of women and depression. | Ronald C Kessler | J Affect Disord | 2003 | 12646294 | Yes |
| 3242 | 7035 | 1172.5 | 240.36 | 40.1 | The occurrence of sleep-disordered breathing among middle-aged adults. | T Young, M Palta, J Dempsey, J Skatrud, S Weber, S Badr | N Engl J Med | 1993 | 8464434 | Yes |
| 3243 | 3516 | 1172.0 | 70.62 | 23.5 | Predicting coiled coils from protein sequences. | A Lupas, M Van Dyke, J Stock | Science | 1991 | 2031185 | Yes |
| 3244 | 1172 | 1172.0 | 36.03 | 36.0 | Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. | M E Bouton | Psychol Bull | 1993 | 8346330 | No |
| 3245 | 1172 | 1172.0 | 27.93 | 27.9 | Context and behavioral processes in extinction. | Mark E Bouton | Learn Mem | 2004 | 15466298 | No |
| 3246 | 2344 | 1172.0 | 100.52 | 50.3 | The lifelong effects of early childhood adversity and toxic stress. | Jack P Shonkoff, Andrew S Garner | Pediatrics | 2012 | 22201156 | Yes |
| 3247 | 3516 | 1172.0 | 106.27 | 35.4 | Development and applications of CRISPR-Cas9 for genome engineering. | Patrick D Hsu, Eric S Lander, Feng Zhang | Cell | 2014 | 24906146 | No |
| 3248 | 1171 | 1171.0 | 23.96 | 24.0 | Apoptosis in neurodegenerative disorders. | M P Mattson | Nat Rev Mol Cell Biol | 2000 | 11253364 | No |
| 3249 | 1171 | 1171.0 | 25.46 | 25.5 | r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock. | Michael J Sanderson | Bioinformatics | 2003 | 12538260 | Yes |
| 3250 | 1171 | 1171.0 | 23.62 | 23.6 | Liver regeneration: from myth to mechanism. | Rebecca Taub | Nat Rev Mol Cell Biol | 2004 | 15459664 | No |
| 3251 | 1171 | 1171.0 | 48.78 | 48.8 | How neuroinflammation contributes to neurodegeneration. | Richard M Ransohoff | Science | 2016 | 27540165 | No |
| 3252 | 3511 | 1170.3 | 91.41 | 30.5 | Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? | Dunyaporn Trachootham, Jerome Alexandre, Peng Huang | Nat Rev Drug Discov | 2009 | 19478820 | No |
| 3253 | 4681 | 1170.2 | 228.77 | 57.2 | NF-κB signaling in inflammation. | Ting Liu, Lingyun Zhang, Donghyun Joo, Shao-Cong Sun | Signal Transduct Target Ther | 2017 | 29158945 | Yes |
| 3254 | 2339 | 1169.5 | 55.42 | 27.7 | Toxoplasmosis. | J G Montoya, O Liesenfeld | Lancet | 2004 | 15194258 | No |
| 3255 | 2339 | 1169.5 | 48.3 | 24.1 | Protein aggregation and neurodegenerative disease. | Christopher A Ross, Michelle A Poirier | Nat Med | 2004 | 15272267 | No |
| 3256 | 3508 | 1169.3 | 88.79 | 29.6 | The widespread regulation of microRNA biogenesis, function and decay. | Jacek Krol, Inga Loedige, Witold Filipowicz | Nat Rev Genet | 2010 | 20661255 | No |
| 3257 | 1169 | 1169.0 | 48.93 | 48.9 | A spreading-activation theory of retrieval in sentence production. | G S Dell | Psychol Rev | 1986 | 3749399 | Yes |
| 3258 | 2338 | 1169.0 | 36.67 | 18.3 | Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. | J D McGhee, P H von Hippel | J Mol Biol | 1974 | 4416620 | Yes |
| 3259 | 1169 | 1169.0 | 15.33 | 15.3 | The nature and significance of platelet products in human plasma. | P Wolf | Br J Haematol | 1967 | 6025241 | Yes |
| 3260 | 1169 | 1169.0 | 26.86 | 26.9 | Neurons with graded response have collective computational properties like those of two-state neurons. | J J Hopfield | Proc Natl Acad Sci U S A | 1984 | 6587342 | Yes |
| 3261 | 1169 | 1169.0 | 51.31 | 51.3 | Coping theory and research: past, present, and future. | R S Lazarus | Psychosom Med | 1993 | 8346332 | No |
| 3262 | 3507 | 1169.0 | 76.62 | 25.5 | Hepatocellular carcinoma. | Josep M Llovet, Andrew Burroughs, Jordi Bruix | Lancet | 2003 | 14667750 | No |
| 3263 | 2337 | 1168.5 | 74.28 | 37.1 | Solubilization of membranes by detergents. | A Helenius, K Simons | Biochim Biophys Acta | 1975 | 1091302 | No |
| 3264 | 2337 | 1168.5 | 68.81 | 34.4 | The capacity of visual working memory for features and conjunctions. | S J Luck, E K Vogel | Nature | 1997 | 9384378 | Yes |
| 3265 | 1168 | 1168.0 | 32.99 | 33.0 | 6-Hydroxy-dopamine induced degeneration of central monoamine neurons. | U Ungerstedt | Eur J Pharmacol | 1968 | 5718510 | Yes |
| 3266 | 1168 | 1168.0 | 44.55 | 44.5 | Molecular aspects of ligand binding to serum albumin. | U Kragh-Hansen | Pharmacol Rev | 1981 | 7027277 | No |
| 3267 | 4672 | 1168.0 | 108.8 | 27.2 | Base-calling of automated sequencer traces using phred. I. Accuracy assessment. | B Ewing, L Hillier, M C Wendl, P Green | Genome Res | 1998 | 9521921 | Yes |
| 3268 | 1168 | 1168.0 | 48.77 | 48.8 | CONSORT-EHEALTH: improving and standardizing evaluation reports of Web-based and mobile health interventions. | Gunther Eysenbach | J Med Internet Res | 2011 | 22209829 | No |
| 3269 | 1167 | 1167.0 | 11.53 | 11.5 | Pathologic anatomy of the pancreas in juvenile diabetes mellitus. | W Gepts | Diabetes | 1965 | 5318831 | Yes |
| 3270 | 1167 | 1167.0 | 39.39 | 39.4 | beta-Lactamases in laboratory and clinical resistance. | D M Livermore | Clin Microbiol Rev | 1995 | 8665470 | No |
| 3271 | 1167 | 1167.0 | 21.45 | 21.4 | Biological robustness. | Hiroaki Kitano | Nat Rev Genet | 2004 | 15520792 | No |
| 3272 | 2334 | 1167.0 | 67.8 | 33.9 | A fast, lock-free approach for efficient parallel counting of occurrences of k-mers. | Guillaume Marçais, Carl Kingsford | Bioinformatics | 2011 | 21217122 | Yes |
| 3273 | 7001 | 1166.8 | 202.37 | 33.7 | The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis. | A Miyake, N P Friedman, M J Emerson, A H Witzki, A Howerter, T D Wager | Cogn Psychol | 2000 | 10945922 | Yes |
| 3274 | 2333 | 1166.5 | 70.8 | 35.4 | Self-management education: history, definition, outcomes, and mechanisms. | Kate R Lorig, Halsted Holman | Ann Behav Med | 2003 | 12867348 | No |
| 3275 | 3498 | 1166.0 | 140.83 | 46.9 | Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. | A DeLean, P J Munson, D Rodbard | Am J Physiol | 1978 | 686171 | Yes |
| 3276 | 1166 | 1166.0 | 20.0 | 20.0 | Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. | M S Wold | Annu Rev Biochem | 1997 | 9242902 | No |
| 3277 | 2332 | 1166.0 | 49.25 | 24.6 | Functions of lipid rafts in biological membranes. | D A Brown, E London | Annu Rev Cell Dev Biol | 1998 | 9891780 | No |
| 3278 | 2332 | 1166.0 | 49.94 | 25.0 | Deep tissue two-photon microscopy. | Fritjof Helmchen, Winfried Denk | Nat Methods | 2005 | 16299478 | No |
| 3279 | 3498 | 1166.0 | 95.39 | 31.8 | Regulation of cancer cell metabolism. | Rob A Cairns, Isaac S Harris, Tak W Mak | Nat Rev Cancer | 2011 | 21258394 | No |
| 3280 | 2332 | 1166.0 | 137.35 | 68.7 | Breast Cancer Treatment: A Review. | Adrienne G Waks, Eric P Winer | JAMA | 2019 | 30667505 | No |
| 3281 | 2331 | 1165.5 | 45.45 | 22.7 | Multiple nuclear factors interact with the immunoglobulin enhancer sequences. | R Sen, D Baltimore | Cell | 1986 | 3091258 | Yes |
| 3282 | 1165 | 1165.0 | 28.39 | 28.4 | Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. | S G Johnsen | Hormones | 1970 | 5527187 | Yes |
| 3283 | 1165 | 1165.0 | 34.61 | 34.6 | Low-molecular-weight heparins. | J I Weitz | N Engl J Med | 1997 | 9278467 | No |
| 3284 | 1165 | 1165.0 | 31.71 | 31.7 | Pharmacology of cannabinoid CB1 and CB2 receptors. | R G Pertwee | Pharmacol Ther | 1997 | 9336020 | No |
| 3285 | 1165 | 1165.0 | 0.0 | 0.0 | A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. | J B Brown | Biochem J | 1955 | 14389222 | Yes |
| 3286 | 1165 | 1165.0 | 33.09 | 33.1 | A comprehensive definition for metabolic syndrome. | Paul L Huang | Dis Model Mech | 2009 | 19407331 | No |
| 3287 | 1165 | 1165.0 | 47.29 | 47.3 | How does sexual minority stigma "get under the skin"? A psychological mediation framework. | Mark L Hatzenbuehler | Psychol Bull | 2009 | 19702379 | No |
| 3288 | 2329 | 1164.5 | 49.52 | 24.8 | Defining the role of mTOR in cancer. | David A Guertin, David M Sabatini | Cancer Cell | 2007 | 17613433 | No |
| 3289 | 2329 | 1164.5 | 52.01 | 26.0 | The Polycomb complex PRC2 and its mark in life. | Raphaël Margueron, Danny Reinberg | Nature | 2011 | 21248841 | No |
| 3290 | 3493 | 1164.3 | 92.34 | 30.8 | Improved vectors and genome-wide libraries for CRISPR screening. | Neville E Sanjana, Ophir Shalem, Feng Zhang | Nat Methods | 2014 | 25075903 | Yes |
| 3291 | 1164 | 1164.0 | 43.32 | 43.3 | Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. | J T Daugirdas | J Am Soc Nephrol | 1993 | 8305648 | Yes |
| 3292 | 2327 | 1163.5 | 51.15 | 25.6 | Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. | William G Kaelin, Peter J Ratcliffe | Mol Cell | 2008 | 18498744 | No |
| 3293 | 1163 | 1163.0 | 26.12 | 26.1 | Cadherins: a molecular family important in selective cell-cell adhesion. | M Takeichi | Annu Rev Biochem | 1990 | 2197976 | No |
| 3294 | 1163 | 1163.0 | 34.76 | 34.8 | Effect of anoxia on ion distribution in the brain. | A J Hansen | Physiol Rev | 1985 | 3880896 | No |
| 3295 | 2326 | 1163.0 | 50.14 | 25.1 | Lymphocyte homing and homeostasis. | E C Butcher, L J Picker | Science | 1996 | 8600538 | No |
| 3296 | 1163 | 1163.0 | 21.91 | 21.9 | Microarray data normalization and transformation. | John Quackenbush | Nat Genet | 2002 | 12454644 | No |
| 3297 | 1163 | 1163.0 | 0.0 | 0.0 | The cytoarchitectonic organization of the spinal cord in the cat. | B Rexed | J Comp Neurol | 1952 | 14946260 | Yes |
| 3298 | 1163 | 1163.0 | 32.8 | 32.8 | Rethinking schizophrenia. | Thomas R Insel | Nature | 2010 | 21068826 | No |
| 3299 | 3487 | 1162.3 | 77.87 | 26.0 | Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. | A L Shapiro, E Viñuela, J V Maizel | Biochem Biophys Res Commun | 1967 | 4861258 | Yes |
| 3300 | 2324 | 1162.0 | 67.05 | 33.5 | Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. | P Brugada, J Brugada | J Am Coll Cardiol | 1992 | 1309182 | Yes |
| 3301 | 1162 | 1162.0 | 30.65 | 30.6 | Presynaptic regulation of catecholamine release. | S Z Langer | Biochem Pharmacol | 1974 | 4617579 | No |
| 3302 | 1162 | 1162.0 | 30.93 | 30.9 | AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. | D Grahame Hardie | Genes Dev | 2011 | 21937710 | No |
| 3303 | 2323 | 1161.5 | 86.34 | 43.2 | Societal and individual determinants of medical care utilization in the United States. | R Andersen, J F Newman | Milbank Mem Fund Q Health Soc | 1973 | 4198894 | Yes |
| 3304 | 2323 | 1161.5 | 43.79 | 21.9 | Rho GTPases: biochemistry and biology. | Aron B Jaffe, Alan Hall | Annu Rev Cell Dev Biol | 2005 | 16212495 | No |
| 3305 | 2323 | 1161.5 | 72.9 | 36.5 | Mechanisms of fibrosis: therapeutic translation for fibrotic disease. | Thomas A Wynn, Thirumalai R Ramalingam | Nat Med | 2012 | 22772564 | No |
| 3306 | 3484 | 1161.3 | 236.99 | 79.0 | MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization. | Kazutaka Katoh, John Rozewicki, Kazunori D Yamada | Brief Bioinform | 2019 | 28968734 | Yes |
| 3307 | 1161 | 1161.0 | 36.48 | 36.5 | Molecular biology of steroid hormone synthesis. | W L Miller | Endocr Rev | 1988 | 3061784 | No |
| 3308 | 2322 | 1161.0 | 55.22 | 27.6 | ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. | Benoît D'Autréaux, Michel B Toledano | Nat Rev Mol Cell Biol | 2007 | 17848967 | No |
| 3309 | 2322 | 1161.0 | 61.7 | 30.9 | BODIPY dyes and their derivatives: syntheses and spectroscopic properties. | Aurore Loudet, Kevin Burgess | Chem Rev | 2007 | 17924696 | Yes |
| 3310 | 2320 | 1160.0 | 29.99 | 15.0 | A Generalization Of The Retention Index System Including Linear Temperature Programmed Gas-Liquid Partition Chromatography. | H Vandendool, P D Kratz | J Chromatogr | 1963 | 14062605 | Yes |
| 3311 | 2319 | 1159.5 | 78.45 | 39.2 | A simple index of Crohn's-disease activity. | R F Harvey, J M Bradshaw | Lancet | 1980 | 6102236 | Yes |
| 3312 | 1159 | 1159.0 | 56.26 | 56.3 | Self-discrepancy: a theory relating self and affect. | E T Higgins | Psychol Rev | 1987 | 3615707 | Yes |
| 3313 | 2318 | 1159.0 | 50.81 | 25.4 | Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. | N Sreerama, R W Woody | Anal Biochem | 2000 | 11112271 | Yes |
| 3314 | 2316 | 1158.0 | 47.55 | 23.8 | Plant pathogens and integrated defence responses to infection. | J L Dangl, J D Jones | Nature | 2001 | 11459065 | No |
| 3315 | 2316 | 1158.0 | 43.68 | 21.8 | NF-kappaB at the crossroads of life and death. | Michael Karin, Anning Lin | Nat Immunol | 2002 | 11875461 | No |
| 3316 | 1158 | 1158.0 | 27.94 | 27.9 | Mode of action of membrane active antimicrobial peptides. | Yechiel Shai | Biopolymers | 2002 | 12491537 | No |
| 3317 | 2315 | 1157.5 | 51.75 | 25.9 | Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. | P van den Driessche, James Watmough | Math Biosci | 2002 | 12387915 | Yes |
| 3318 | 2315 | 1157.5 | 50.5 | 25.2 | Esophageal cancer. | Peter C Enzinger, Robert J Mayer | N Engl J Med | 2003 | 14657432 | No |
| 3319 | 2315 | 1157.5 | 51.4 | 25.7 | microRNA functions. | Natascha Bushati, Stephen M Cohen | Annu Rev Cell Dev Biol | 2007 | 17506695 | No |
| 3320 | 1157 | 1157.0 | 26.66 | 26.7 | Transcriptional paradigms in mammalian mitochondrial biogenesis and function. | Richard C Scarpulla | Physiol Rev | 2008 | 18391175 | No |
| 3321 | 1156 | 1156.0 | 60.38 | 60.4 | A "rationalized" arcsine transform. | G A Studebaker | J Speech Hear Res | 1985 | 4046587 | Yes |
| 3322 | 1156 | 1156.0 | 21.76 | 21.8 | Biogenic amines and the states of sleep. | M Jouvet | Science | 1969 | 4303225 | No |
| 3323 | 1156 | 1156.0 | 44.01 | 44.0 | Freezing of living cells: mechanisms and implications. | P Mazur | Am J Physiol | 1984 | 6383068 | No |
| 3324 | 2312 | 1156.0 | 66.29 | 33.1 | Relaxing the rule of ten events per variable in logistic and Cox regression. | Eric Vittinghoff, Charles E McCulloch | Am J Epidemiol | 2007 | 17182981 | Yes |
| 3325 | 1156 | 1156.0 | 0.0 | 0.0 | Observations on the isolated phrenic nerve diaphragm preparation of the rat. | E Bulbring | Br J Pharmacol Chemother | 1946 | 20999334 | Yes |
| 3326 | 1156 | 1156.0 | 60.85 | 60.9 | The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. | Martins Ekor | Front Pharmacol | 2014 | 24454289 | No |
| 3327 | 2311 | 1155.5 | 64.69 | 32.3 | Growth of a rat neuroblastoma cell line in serum-free supplemented medium. | J E Bottenstein, G H Sato | Proc Natl Acad Sci U S A | 1979 | 284369 | Yes |
| 3328 | 2311 | 1155.5 | 38.84 | 19.4 | Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. | R W Butcher, E W Sutherland | J Biol Chem | 1962 | 13875173 | Yes |
| 3329 | 4622 | 1155.5 | 249.95 | 62.5 | The Cambridge Structural Database. | Colin R Groom, Ian J Bruno, Matthew P Lightfoot, Suzanna C Ward | Acta Crystallogr B Struct Sci Cryst Eng Mater | 2016 | 27048719 | Yes |
| 3330 | 3466 | 1155.3 | 84.86 | 28.3 | High resolution two-dimensional electrophoresis of basic as well as acidic proteins. | P Z O'Farrell, H M Goodman, P H O'Farrell | Cell | 1977 | 23215 | Yes |
| 3331 | 1155 | 1155.0 | 22.02 | 22.0 | RNA metabolism in the HeLa cell nucleus. | S Penman | J Mol Biol | 1966 | 5961144 | Yes |
| 3332 | 1155 | 1155.0 | 25.84 | 25.8 | Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. | H J Dargie | Lancet | 2001 | 11356434 | Yes |
| 3333 | 1155 | 1155.0 | 0.0 | 0.0 | The powerful placebo. | H K Beecher | J Am Med Assoc | 1955 | 13271123 | Yes |
| 3334 | 2310 | 1155.0 | 44.41 | 22.2 | STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. | Hiroki Ishikawa, Glen N Barber | Nature | 2008 | 18724357 | Yes |
| 3335 | 3463 | 1154.3 | 248.1 | 82.7 | Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles. | Aldenor G Santos, Gisele O da Rocha, Jailson B de Andrade | Sci Rep | 2019 | 30626917 | Yes |
| 3336 | 1154 | 1154.0 | 29.06 | 29.1 | Two-stage model of memory trace formation: a role for "noisy" brain states. | G Buzsáki | Neuroscience | 1989 | 2687720 | No |
| 3337 | 1154 | 1154.0 | 11.9 | 11.9 | Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. | J Altman | J Comp Neurol | 1969 | 5361244 | Yes |
| 3338 | 1154 | 1154.0 | 35.83 | 35.8 | Strategies of antioxidant defense. | H Sies | Eur J Biochem | 1993 | 7688300 | No |
| 3339 | 1154 | 1154.0 | 26.73 | 26.7 | Amyloid, the presenilins and Alzheimer's disease. | J Hardy | Trends Neurosci | 1997 | 9106355 | No |
| 3340 | 1154 | 1154.0 | 29.24 | 29.2 | The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. | R A Jain | Biomaterials | 2000 | 11055295 | No |
| 3341 | 1154 | 1154.0 | 22.1 | 22.1 | Regulation of cadherin-mediated adhesion in morphogenesis. | Barry M Gumbiner | Nat Rev Mol Cell Biol | 2005 | 16025097 | No |
| 3342 | 1153 | 1153.0 | 20.43 | 20.4 | Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. | Eric C Lai | Nat Genet | 2002 | 11896390 | Yes |
| 3343 | 1153 | 1153.0 | 22.38 | 22.4 | Inferences, questions and possibilities in Toll-like receptor signalling. | Bruce Beutler | Nature | 2004 | 15241424 | No |
| 3344 | 1153 | 1153.0 | 24.07 | 24.1 | Version 1.2 of the Crystallography and NMR system. | Axel T Brunger | Nat Protoc | 2007 | 18007608 | Yes |
| 3345 | 1153 | 1153.0 | 29.15 | 29.1 | Ovarian cancer development and metastasis. | Ernst Lengyel | Am J Pathol | 2010 | 20651229 | Yes |
| 3346 | 2306 | 1153.0 | 64.0 | 32.0 | Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. | Patrick S Ward, Craig B Thompson | Cancer Cell | 2012 | 22439925 | No |
| 3347 | 3458 | 1152.7 | 235.02 | 78.3 | Sample Size in Qualitative Interview Studies: Guided by Information Power. | Kirsti Malterud, Volkert Dirk Siersma, Ann Dorrit Guassora | Qual Health Res | 2016 | 26613970 | Yes |
| 3348 | 1152 | 1152.0 | 23.96 | 24.0 | Evolution of ageing. | T B Kirkwood | Nature | 1977 | 593350 | Yes |
| 3349 | 2304 | 1152.0 | 79.05 | 39.5 | A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. | Walter J Paulus, Carsten Tschöpe | J Am Coll Cardiol | 2013 | 23684677 | No |
| 3350 | 2303 | 1151.5 | 46.41 | 23.2 | A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. | N C Andrews, D V Faller | Nucleic Acids Res | 1991 | 2041787 | Yes |
| 3351 | 2303 | 1151.5 | 51.73 | 25.9 | Shape-controlled synthesis of gold and silver nanoparticles. | Yugang Sun, Younan Xia | Science | 2002 | 12481134 | Yes |
| 3352 | 2302 | 1151.0 | 71.05 | 35.5 | Role of oxidized low density lipoprotein in atherogenesis. | J L Witztum, D Steinberg | J Clin Invest | 1991 | 1752940 | No |
| 3353 | 1151 | 1151.0 | 36.04 | 36.0 | Relations between the statistics of natural images and the response properties of cortical cells. | D J Field | J Opt Soc Am A | 1987 | 3430225 | Yes |
| 3354 | 2302 | 1151.0 | 66.8 | 33.4 | Excitatory amino acids as a final common pathway for neurologic disorders. | S A Lipton, P A Rosenberg | N Engl J Med | 1994 | 7905600 | No |
| 3355 | 1151 | 1151.0 | 32.96 | 33.0 | The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. | S Nolen-Hoeksema | J Abnorm Psychol | 2000 | 11016119 | Yes |
| 3356 | 1151 | 1151.0 | 31.56 | 31.6 | Riddle of biofilm resistance. | K Lewis | Antimicrob Agents Chemother | 2001 | 11257008 | No |
| 3357 | 1151 | 1151.0 | 28.19 | 28.2 | Formation and function of the myofibroblast during tissue repair. | Boris Hinz | J Invest Dermatol | 2007 | 17299435 | No |
| 3358 | 1151 | 1151.0 | 54.82 | 54.8 | Sleep health: can we define it? Does it matter? | Daniel J Buysse | Sleep | 2014 | 24470692 | Yes |
| 3359 | 3452 | 1150.7 | 98.63 | 32.9 | A sensitive and reliable locomotor rating scale for open field testing in rats. | D M Basso, M S Beattie, J C Bresnahan | J Neurotrauma | 1995 | 7783230 | Yes |
| 3360 | 2301 | 1150.5 | 90.82 | 45.4 | Statistical methods for assessing measurement error (reliability) in variables relevant to sports medicine. | G Atkinson, A M Nevill | Sports Med | 1998 | 9820922 | No |
| 3361 | 1150 | 1150.0 | 21.96 | 22.0 | Contingent genetic regulatory events in T lymphocyte activation. | G R Crabtree | Science | 1989 | 2783497 | Yes |
| 3362 | 1150 | 1150.0 | 28.62 | 28.6 | Selective coronary arteriography. I. A percutaneous transfemoral technic. | M P Judkins | Radiology | 1967 | 6048074 | Yes |
| 3363 | 1150 | 1150.0 | 23.45 | 23.4 | Understanding the odd science of aging. | Thomas B L Kirkwood | Cell | 2005 | 15734677 | No |
| 3364 | 1150 | 1150.0 | 25.95 | 25.9 | Viruses in the sea. | Curtis A Suttle | Nature | 2005 | 16163346 | No |
| 3365 | 2300 | 1150.0 | 61.8 | 30.9 | Mechanisms of mitophagy. | Richard J Youle, Derek P Narendra | Nat Rev Mol Cell Biol | 2011 | 21179058 | No |
| 3366 | 1150 | 1150.0 | 28.01 | 28.0 | Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. | Christof M Niemeyer | Angew Chem Int Ed Engl | 2001 | 29712109 | No |
| 3367 | 8043 | 1149.0 | 248.22 | 35.5 | Toxicity and response criteria of the Eastern Cooperative Oncology Group. | M M Oken, R H Creech, D C Tormey, J Horton, T E Davis, E T McFadden, P P Carbone | Am J Clin Oncol | 1982 | 7165009 | Yes |
| 3368 | 1149 | 1149.0 | 31.45 | 31.4 | Leishmaniasis. | B L Herwaldt | Lancet | 1999 | 10513726 | No |
| 3369 | 1149 | 1149.0 | 0.0 | 0.0 | A sensitive method for the assay of 5-hydroxytryptamine. | J R Vane | Br J Pharmacol Chemother | 1957 | 13460242 | Yes |
| 3370 | 1149 | 1149.0 | 27.44 | 27.4 | What is a support vector machine? | William S Noble | Nat Biotechnol | 2006 | 17160063 | No |
| 3371 | 1149 | 1149.0 | 28.15 | 28.1 | Immortal time bias in pharmaco-epidemiology. | Samy Suissa | Am J Epidemiol | 2008 | 18056625 | No |
| 3372 | 1149 | 1149.0 | 25.22 | 25.2 | Next-generation DNA sequencing methods. | Elaine R Mardis | Annu Rev Genomics Hum Genet | 2008 | 18576944 | No |
| 3373 | 2297 | 1148.5 | 50.64 | 25.3 | Plasminogen: purification from human plasma by affinity chromatography. | D G Deutsch, E T Mertz | Science | 1970 | 5475635 | Yes |
| 3374 | 6889 | 1148.2 | 156.84 | 26.1 | Staging of brain pathology related to sporadic Parkinson's disease. | Heiko Braak, Kelly Del Tredici, Udo Rüb, Rob A I de Vos, Ernst N H Jansen Steur, Eva Braak | Neurobiol Aging | 2003 | 12498954 | Yes |
| 3375 | 1148 | 1148.0 | 34.35 | 34.4 | Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. | D B Clewell | J Bacteriol | 1972 | 4336693 | Yes |
| 3376 | 2296 | 1148.0 | 85.91 | 43.0 | The Posttraumatic Growth Inventory: measuring the positive legacy of trauma. | R G Tedeschi, L G Calhoun | J Trauma Stress | 1996 | 8827649 | Yes |
| 3377 | 1148 | 1148.0 | 24.07 | 24.1 | Stem cells in the central nervous system. | R McKay | Science | 1997 | 9082987 | No |
| 3378 | 1148 | 1148.0 | 26.82 | 26.8 | Aptamers: an emerging class of molecules that rival antibodies in diagnostics. | S D Jayasena | Clin Chem | 1999 | 10471678 | No |
| 3379 | 1148 | 1148.0 | 24.89 | 24.9 | G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. | Jeffery T Davis | Angew Chem Int Ed Engl | 2004 | 14755695 | No |
| 3380 | 1148 | 1148.0 | 0.0 | 0.0 | Fertilizing capacity of spermatozoa deposited into the fallopian tubes. | M C Chang | Nature | 1951 | 14882325 | Yes |
| 3381 | 3444 | 1148.0 | 92.29 | 30.8 | Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. | Robert G Hart, Lesly A Pearce, Maria I Aguilar | Ann Intern Med | 2007 | 17577005 | Yes |
| 3382 | 2295 | 1147.5 | 72.61 | 36.3 | Central sensitization: a generator of pain hypersensitivity by central neural plasticity. | Alban Latremoliere, Clifford J Woolf | J Pain | 2009 | 19712899 | No |
| 3383 | 1147 | 1147.0 | 22.0 | 22.0 | Mechanisms and consequences of activation of protein kinase B/Akt. | J Downward | Curr Opin Cell Biol | 1998 | 9561851 | No |
| 3384 | 1147 | 1147.0 | 33.84 | 33.8 | Cognitive and affective development in adolescence. | Laurence Steinberg | Trends Cogn Sci | 2005 | 15668099 | No |
| 3385 | 1147 | 1147.0 | 24.32 | 24.3 | VEGF as a key mediator of angiogenesis in cancer. | Peter Carmeliet | Oncology | 2005 | 16301830 | No |
| 3386 | 1147 | 1147.0 | 30.01 | 30.0 | Time is brain--quantified. | Jeffrey L Saver | Stroke | 2006 | 16339467 | Yes |
| 3387 | 1146 | 1146.0 | 42.2 | 42.2 | Omega-3 fatty acids in health and disease and in growth and development. | A P Simopoulos | Am J Clin Nutr | 1991 | 1908631 | No |
| 3388 | 1146 | 1146.0 | 31.98 | 32.0 | DNA topoisomerases. | M Gellert | Annu Rev Biochem | 1981 | 6267993 | No |
| 3389 | 3438 | 1146.0 | 67.84 | 22.6 | SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. | Jay D Horton, Joseph L Goldstein, Michael S Brown | J Clin Invest | 2002 | 11994399 | No |
| 3390 | 1146 | 1146.0 | 30.94 | 30.9 | Stronger Brønsted acids. | Takahiko Akiyama | Chem Rev | 2007 | 17983247 | Yes |
| 3391 | 3437 | 1145.7 | 82.77 | 27.6 | Mechanisms linking obesity to insulin resistance and type 2 diabetes. | Steven E Kahn, Rebecca L Hull, Kristina M Utzschneider | Nature | 2006 | 17167471 | No |
| 3392 | 2291 | 1145.5 | 44.63 | 22.3 | Tumour-cell invasion and migration: diversity and escape mechanisms. | Peter Friedl, Katarina Wolf | Nat Rev Cancer | 2003 | 12724734 | No |
| 3393 | 1145 | 1145.0 | 31.08 | 31.1 | Diseases of the mitochondrial DNA. | D C Wallace | Annu Rev Biochem | 1992 | 1497308 | No |
| 3394 | 1145 | 1145.0 | 9.79 | 9.8 | A New Serum Type System In Man--The Lp System. | K Berg | Acta Pathol Microbiol Scand | 1963 | 14064818 | Yes |
| 3395 | 1145 | 1145.0 | 36.3 | 36.3 | Social support and health: a review of physiological processes potentially underlying links to disease outcomes. | Bert N Uchino | J Behav Med | 2006 | 16758315 | No |
| 3396 | 1145 | 1145.0 | 31.86 | 31.9 | Neurophysiological and computational principles of cortical rhythms in cognition. | Xiao-Jing Wang | Physiol Rev | 2010 | 20664082 | No |
| 3397 | 2289 | 1144.5 | 61.41 | 30.7 | Mechanisms of biofilm resistance to antimicrobial agents. | T F Mah, G A O'Toole | Trends Microbiol | 2001 | 11166241 | No |
| 3398 | 4577 | 1144.2 | 110.7 | 27.7 | Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. | H Nielsen, J Engelbrecht, S Brunak, G von Heijne | Protein Eng | 1997 | 9051728 | Yes |
| 3399 | 1144 | 1144.0 | 52.96 | 53.0 | Analysis of Fickian and non-Fickian drug release from polymers. | N A Peppas | Pharm Acta Helv | 1985 | 4011621 | Yes |
| 3400 | 1144 | 1144.0 | 38.73 | 38.7 | Selective attention and the organization of visual information. | J Duncan | J Exp Psychol Gen | 1984 | 6240521 | Yes |
| 3401 | 1144 | 1144.0 | 33.42 | 33.4 | Reducing children's television viewing to prevent obesity: a randomized controlled trial. | T N Robinson | JAMA | 1999 | 10546696 | Yes |
| 3402 | 1144 | 1144.0 | 21.81 | 21.8 | VEGF and the quest for tumour angiogenesis factors. | Napoleone Ferrara | Nat Rev Cancer | 2002 | 12360282 | No |
| 3403 | 4574 | 1143.5 | 214.48 | 53.6 | Genome sequence-based species delimitation with confidence intervals and improved distance functions. | Jan P Meier-Kolthoff, Alexander F Auch, Hans-Peter Klenk, Markus Göker | BMC Bioinformatics | 2013 | 23432962 | Yes |
| 3404 | 1143 | 1143.0 | 45.29 | 45.3 | Radioimmunological determination of human C-peptide in serum. | L G Heding | Diabetologia | 1975 | 1239396 | Yes |
| 3405 | 2286 | 1143.0 | 60.4 | 30.2 | Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. | M J Casadaban, S N Cohen | J Mol Biol | 1980 | 6997493 | Yes |
| 3406 | 1143 | 1143.0 | 25.79 | 25.8 | The columnar organization of the neocortex. | V B Mountcastle | Brain | 1997 | 9153131 | No |
| 3407 | 1143 | 1143.0 | 25.57 | 25.6 | Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. | Michael J Sanderson | Mol Biol Evol | 2002 | 11752195 | Yes |
| 3408 | 2286 | 1143.0 | 42.47 | 21.2 | The druggable genome. | Andrew L Hopkins, Colin R Groom | Nat Rev Drug Discov | 2002 | 12209152 | No |
| 3409 | 1143 | 1143.0 | 30.45 | 30.4 | Disseminating innovations in health care. | Donald M Berwick | JAMA | 2003 | 12697800 | Yes |
| 3410 | 1143 | 1143.0 | 0.0 | 0.0 | Knee joint changes after meniscectomy. | T J Fairbank | J Bone Joint Surg Br | 1948 | 18894618 | Yes |
| 3411 | 2285 | 1142.5 | 83.54 | 41.8 | The Modified Mini-Mental State (3MS) examination. | E L Teng, H C Chui | J Clin Psychiatry | 1987 | 3611032 | Yes |
| 3412 | 3426 | 1142.0 | 108.27 | 36.1 | Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. | G M Wahl, M Stern, G R Stark | Proc Natl Acad Sci U S A | 1979 | 291033 | Yes |
| 3413 | 1142 | 1142.0 | 31.85 | 31.9 | An improved fluorometric assay for DNA. | R T Hinegardner | Anal Biochem | 1971 | 5544593 | Yes |
| 3414 | 2284 | 1142.0 | 60.06 | 30.0 | Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. | I Chopra, M Roberts | Microbiol Mol Biol Rev | 2001 | 11381101 | Yes |
| 3415 | 4568 | 1142.0 | 130.23 | 32.6 | GCTA: a tool for genome-wide complex trait analysis. | Jian Yang, S Hong Lee, Michael E Goddard, Peter M Visscher | Am J Hum Genet | 2011 | 21167468 | Yes |
| 3416 | 2284 | 1142.0 | 71.85 | 35.9 | Long non-coding RNAs: new players in cell differentiation and development. | Alessandro Fatica, Irene Bozzoni | Nat Rev Genet | 2014 | 24296535 | No |
| 3417 | 2282 | 1141.0 | 66.79 | 33.4 | Nitric oxide synthases in mammals. | R G Knowles, S Moncada | Biochem J | 1994 | 7510950 | No |
| 3418 | 1141 | 1141.0 | 30.98 | 31.0 | Venous thrombosis: a multicausal disease. | F R Rosendaal | Lancet | 1999 | 10209995 | No |
| 3419 | 1141 | 1141.0 | 23.93 | 23.9 | Molecular imaging of cancer with positron emission tomography. | Sanjiv Sam Gambhir | Nat Rev Cancer | 2002 | 12209157 | No |
| 3420 | 1141 | 1141.0 | 30.68 | 30.7 | A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. | Ron Hardman | Environ Health Perspect | 2006 | 16451849 | No |
| 3421 | 1141 | 1141.0 | 40.74 | 40.7 | Visual attention: the past 25 years. | Marisa Carrasco | Vision Res | 2011 | 21549742 | No |
| 3422 | 1141 | 1141.0 | 57.47 | 57.5 | Systematic text condensation: a strategy for qualitative analysis. | Kirsti Malterud | Scand J Public Health | 2012 | 23221918 | Yes |
| 3423 | 2281 | 1140.5 | 67.05 | 33.5 | Health effects of fine particulate air pollution: lines that connect. | C Arden Pope, Douglas W Dockery | J Air Waste Manag Assoc | 2006 | 16805397 | No |
| 3424 | 2281 | 1140.5 | 51.33 | 25.7 | Next-generation DNA sequencing. | Jay Shendure, Hanlee Ji | Nat Biotechnol | 2008 | 18846087 | Yes |
| 3425 | 2280 | 1140.0 | 46.74 | 23.4 | Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. | G A Gonzalez, M R Montminy | Cell | 1989 | 2573431 | Yes |
| 3426 | 1140 | 1140.0 | 21.44 | 21.4 | The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. | Y Yarden | Eur J Cancer | 2001 | 11597398 | No |
| 3427 | 1140 | 1140.0 | 21.3 | 21.3 | The power and the promise of DNA methylation markers. | Peter W Laird | Nat Rev Cancer | 2003 | 12671664 | No |
| 3428 | 2280 | 1140.0 | 75.52 | 37.8 | The complexity of NF-κB signaling in inflammation and cancer. | Bastian Hoesel, Johannes A Schmid | Mol Cancer | 2013 | 23915189 | No |
| 3429 | 2279 | 1139.5 | 76.51 | 38.3 | Pharmaceuticals and personal care products in the environment: agents of subtle change? | C G Daughton, T A Ternes | Environ Health Perspect | 1999 | 10592150 | No |
| 3430 | 1139 | 1139.0 | 28.7 | 28.7 | Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. | I J Fidler | Cancer Res | 1990 | 1698118 | Yes |
| 3431 | 1139 | 1139.0 | 20.46 | 20.5 | Shrinkage necrosis: a distinct mode of cellular death. | J F Kerr | J Pathol | 1971 | 4108566 | Yes |
| 3432 | 1139 | 1139.0 | 22.79 | 22.8 | Diffusion-in-gel methods for immunological analysis. II. | O Ouchterlony | Prog Allergy | 1962 | 14482809 | Yes |
| 3433 | 1139 | 1139.0 | 20.22 | 20.2 | NFAT proteins: key regulators of T-cell development and function. | Fernando Macian | Nat Rev Immunol | 2005 | 15928679 | No |
| 3434 | 1139 | 1139.0 | 0.0 | 0.0 | A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. | R D Hotchkiss | Arch Biochem | 1948 | 18921848 | Yes |
| 3435 | 3415 | 1138.3 | 97.0 | 32.3 | Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. | Geoffrey R Norman, Jeff A Sloan, Kathleen W Wyrwich | Med Care | 2003 | 12719681 | No |
| 3436 | 1138 | 1138.0 | 33.95 | 34.0 | Unstable angina. A classification. | E Braunwald | Circulation | 1989 | 2752565 | Yes |
| 3437 | 2275 | 1137.5 | 44.24 | 22.1 | Homeobox genes and axial patterning. | W McGinnis, R Krumlauf | Cell | 1992 | 1346368 | No |
| 3438 | 1137 | 1137.0 | 40.3 | 40.3 | Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. | W A Catterall | Annu Rev Pharmacol Toxicol | 1980 | 6247957 | No |
| 3439 | 1137 | 1137.0 | 32.98 | 33.0 | Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. | P S Tofts | J Magn Reson Imaging | 1997 | 9039598 | No |
| 3440 | 1137 | 1137.0 | 21.0 | 21.0 | Regulation of phosphoinositide-specific phospholipase C. | S G Rhee | Annu Rev Biochem | 2001 | 11395409 | No |
| 3441 | 1137 | 1137.0 | 16.65 | 16.6 | Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. | R J Pennington | Biochem J | 1961 | 13734134 | Yes |
| 3442 | 5684 | 1136.8 | 220.77 | 44.2 | Salmon provides fast and bias-aware quantification of transcript expression. | Rob Patro, Geet Duggal, Michael I Love, Rafael A Irizarry, Carl Kingsford | Nat Methods | 2017 | 28263959 | Yes |
| 3443 | 3410 | 1136.7 | 105.35 | 35.1 | PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. | J W Varni, M Seid, P S Kurtin | Med Care | 2001 | 11468499 | Yes |
| 3444 | 3408 | 1136.0 | 72.55 | 24.2 | A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. | M Serrano, G J Hannon, D Beach | Nature | 1993 | 8259215 | Yes |
| 3445 | 1136 | 1136.0 | 23.22 | 23.2 | Differentiation and proliferation of hematopoietic stem cells. | M Ogawa | Blood | 1993 | 8499622 | No |
| 3446 | 1136 | 1136.0 | 38.18 | 38.2 | Globalization of diabetes: the role of diet, lifestyle, and genes. | Frank B Hu | Diabetes Care | 2011 | 21617109 | No |
| 3447 | 2271 | 1135.5 | 84.57 | 42.3 | Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. | I B Wilson, P D Cleary | JAMA | 1995 | 7996652 | Yes |
| 3448 | 4541 | 1135.2 | 111.21 | 27.8 | Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. | Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod Menon | Proc Natl Acad Sci U S A | 2003 | 12506194 | Yes |
| 3449 | 1135 | 1135.0 | 21.59 | 21.6 | Structure of chromatin. | R D Kornberg | Annu Rev Biochem | 1977 | 332067 | No |
| 3450 | 2270 | 1135.0 | 0.0 | 0.0 | Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. | H H Ussing, K Zerahn | Acta Physiol Scand | 1951 | 14868510 | Yes |
| 3451 | 1135 | 1135.0 | 30.93 | 30.9 | Cholinesterase inhibitors for Alzheimer's disease. | J Birks | Cochrane Database Syst Rev | 2006 | 16437532 | No |
| 3452 | 3404 | 1134.7 | 93.2 | 31.1 | Cytochemical identification of monocytes and granulocytes. | L T Yam, C Y Li, W H Crosby | Am J Clin Pathol | 1971 | 5549896 | Yes |
| 3453 | 2269 | 1134.5 | 92.68 | 46.3 | Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. | L A Clark, D Watson | J Abnorm Psychol | 1991 | 1918611 | No |
| 3454 | 6807 | 1134.5 | 146.51 | 24.4 | Obesity is associated with macrophage accumulation in adipose tissue. | Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W Ferrante | J Clin Invest | 2003 | 14679176 | Yes |
| 3455 | 3402 | 1134.0 | 101.13 | 33.7 | HMMER web server: interactive sequence similarity searching. | Robert D Finn, Jody Clements, Sean R Eddy | Nucleic Acids Res | 2011 | 21593126 | Yes |
| 3456 | 2267 | 1133.5 | 50.88 | 25.4 | Modes of resistance to anti-angiogenic therapy. | Gabriele Bergers, Douglas Hanahan | Nat Rev Cancer | 2008 | 18650835 | No |
| 3457 | 1133 | 1133.0 | 31.03 | 31.0 | Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units. | C M Venkatachalam | Biopolymers | 1968 | 5685102 | Yes |
| 3458 | 2266 | 1133.0 | 50.2 | 25.1 | Obesity and insulin resistance. | B B Kahn, J S Flier | J Clin Invest | 2000 | 10953022 | No |
| 3459 | 1133 | 1133.0 | 0.0 | 0.0 | The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. | J Vague | Am J Clin Nutr | 1956 | 13282851 | Yes |
| 3460 | 2265 | 1132.5 | 85.04 | 42.5 | The content validity index: are you sure you know what's being reported? Critique and recommendations. | Denise F Polit, Cheryl Tatano Beck | Res Nurs Health | 2006 | 16977646 | Yes |
| 3461 | 2264 | 1132.0 | 76.05 | 38.0 | Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. | A E Czeizel, I Dudás | N Engl J Med | 1992 | 1307234 | Yes |
| 3462 | 1132 | 1132.0 | 32.13 | 32.1 | Cholesterol and the cell membrane. | P L Yeagle | Biochim Biophys Acta | 1985 | 3904832 | No |
| 3463 | 1132 | 1132.0 | 17.39 | 17.4 | Inherited Antithrombin Deficiency Causing Thrombophilia. | O Egeberg | Thromb Diath Haemorrh | 1965 | 14347873 | Yes |
| 3464 | 2264 | 1132.0 | 63.0 | 31.5 | Burden of major musculoskeletal conditions. | Anthony D Woolf, Bruce Pfleger | Bull World Health Organ | 2003 | 14710506 | No |
| 3465 | 2263 | 1131.5 | 83.91 | 42.0 | Long Noncoding RNAs in Cancer Pathways. | Adam M Schmitt, Howard Y Chang | Cancer Cell | 2016 | 27070700 | No |
| 3466 | 3394 | 1131.3 | 120.28 | 40.1 | Neighborhoods and violent crime: a multilevel study of collective efficacy. | R J Sampson, S W Raudenbush, F Earls | Science | 1997 | 9252316 | Yes |
| 3467 | 1131 | 1131.0 | 26.61 | 26.6 | Mechanisms of lipid peroxide formation in animal tissues. | E D Wills | Biochem J | 1966 | 5964963 | Yes |
| 3468 | 1131 | 1131.0 | 36.25 | 36.2 | Predictors of postpartum depression: an update. | C T Beck | Nurs Res | 2001 | 11570712 | Yes |
| 3469 | 2262 | 1131.0 | 59.45 | 29.7 | Fitness effects on the cognitive function of older adults: a meta-analytic study. | Stanley Colcombe, Arthur F Kramer | Psychol Sci | 2003 | 12661673 | Yes |
| 3470 | 1131 | 1131.0 | 35.06 | 35.1 | Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. | Ronald A Hites | Environ Sci Technol | 2004 | 14998004 | Yes |
| 3471 | 1131 | 1131.0 | 25.98 | 26.0 | Anatomy and regulation of the central melanocortin system. | Roger D Cone | Nat Neurosci | 2005 | 15856065 | No |
| 3472 | 1131 | 1131.0 | 22.39 | 22.4 | Models, mechanisms and clinical evidence for cancer dormancy. | Julio A Aguirre-Ghiso | Nat Rev Cancer | 2007 | 17957189 | No |
| 3473 | 3392 | 1130.7 | 90.41 | 30.1 | A nonparametric method for automatic correction of intensity nonuniformity in MRI data. | J G Sled, A P Zijdenbos, A C Evans | IEEE Trans Med Imaging | 1998 | 9617910 | Yes |
| 3474 | 1130 | 1130.0 | 23.97 | 24.0 | Fluorescence spectroscopy of single biomolecules. | S Weiss | Science | 1999 | 10073925 | No |
| 3475 | 1130 | 1130.0 | 26.08 | 26.1 | Allelic discrimination using fluorogenic probes and the 5' nuclease assay. | K J Livak | Genet Anal | 1999 | 10084106 | Yes |
| 3476 | 1130 | 1130.0 | 0.0 | 0.0 | pA, a new scale for the measurement of drug antagonism. | H O Schild | Br J Pharmacol Chemother | 1947 | 20258355 | Yes |
| 3477 | 4520 | 1130.0 | 159.58 | 39.9 | cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination. | Ali Punjani, John L Rubinstein, David J Fleet, Marcus A Brubaker | Nat Methods | 2017 | 28165473 | Yes |
| 3478 | 2259 | 1129.5 | 78.55 | 39.3 | A formula to estimate the approximate surface area if height and weight be known. 1916. | D Du Bois, E F Du Bois | Nutrition | 1989 | 2520314 | No |
| 3479 | 2259 | 1129.5 | 58.28 | 29.1 | Protein oxidation in aging, disease, and oxidative stress. | B S Berlett, E R Stadtman | J Biol Chem | 1997 | 9252331 | No |
| 3480 | 3387 | 1129.0 | 90.69 | 30.2 | Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. | R Schreck, P Rieber, P A Baeuerle | EMBO J | 1991 | 2065663 | Yes |
| 3481 | 1129 | 1129.0 | 28.5 | 28.5 | Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. | M M Weiser | J Biol Chem | 1973 | 4698230 | Yes |
| 3482 | 1129 | 1129.0 | 24.94 | 24.9 | Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. | M Kozak | Nucleic Acids Res | 1981 | 7301588 | Yes |
| 3483 | 2258 | 1129.0 | 77.0 | 38.5 | Consensus methods for medical and health services research. | J Jones, D Hunter | BMJ | 1995 | 7640549 | No |
| 3484 | 1129 | 1129.0 | 20.41 | 20.4 | DNA methylation in cancer: too much, but also too little. | Melanie Ehrlich | Oncogene | 2002 | 12154403 | No |
| 3485 | 2258 | 1129.0 | 67.58 | 33.8 | Ischemia and reperfusion--from mechanism to translation. | Holger K Eltzschig, Tobias Eckle | Nat Med | 2011 | 22064429 | No |
| 3486 | 2257 | 1128.5 | 55.08 | 27.5 | The protective effects of estrogen on the cardiovascular system. | M E Mendelsohn, R H Karas | N Engl J Med | 1999 | 10362825 | No |
| 3487 | 2257 | 1128.5 | 48.01 | 24.0 | Roles of CHOP/GADD153 in endoplasmic reticulum stress. | S Oyadomari, M Mori | Cell Death Differ | 2004 | 14685163 | No |
| 3488 | 2257 | 1128.5 | 54.8 | 27.4 | Adipocytokines: mediators linking adipose tissue, inflammation and immunity. | Herbert Tilg, Alexander R Moschen | Nat Rev Immunol | 2006 | 16998510 | No |
| 3489 | 1128 | 1128.0 | 67.73 | 67.7 | Cytoprotection by prostaglandins. | A Robert | Gastroenterology | 1979 | 38173 | Yes |
| 3490 | 1128 | 1128.0 | 23.74 | 23.7 | Mutator phenotype may be required for multistage carcinogenesis. | L A Loeb | Cancer Res | 1991 | 2039987 | No |
| 3491 | 1128 | 1128.0 | 42.73 | 42.7 | On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. | D Collen | Thromb Haemost | 1980 | 6450468 | No |
| 3492 | 1128 | 1128.0 | 22.13 | 22.1 | Regulation of transcription by MAP kinase cascades. | R Treisman | Curr Opin Cell Biol | 1996 | 8791420 | No |
| 3493 | 1128 | 1128.0 | 20.16 | 20.2 | The development of neural stem cells. | S Temple | Nature | 2001 | 11689956 | No |
| 3494 | 1128 | 1128.0 | 0.0 | 0.0 | Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. | A B Stavitsky | J Immunol | 1954 | 13163409 | Yes |
| 3495 | 1128 | 1128.0 | 40.21 | 40.2 | The pathobiology of vascular dementia. | Costantino Iadecola | Neuron | 2013 | 24267647 | No |
| 3496 | 2256 | 1128.0 | 90.62 | 45.3 | Macrophages in Tissue Repair, Regeneration, and Fibrosis. | Thomas A Wynn, Kevin M Vannella | Immunity | 2016 | 26982353 | No |
| 3497 | 2255 | 1127.5 | 88.64 | 44.3 | Communication by Extracellular Vesicles: Where We Are and Where We Need to Go. | Mercedes Tkach, Clotilde Théry | Cell | 2016 | 26967288 | No |
| 3498 | 1127 | 1127.0 | 52.06 | 52.1 | Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder. | M Rutter | Br J Psychiatry | 1985 | 3830321 | Yes |
| 3499 | 2254 | 1127.0 | 46.18 | 23.1 | Genomic control for association studies. | B Devlin, K Roeder | Biometrics | 1999 | 11315092 | Yes |
| 3500 | 1127 | 1127.0 | 0.0 | 0.0 | The Stability of Broken Ends of Chromosomes in Zea Mays. | B McClintock | Genetics | 1941 | 17247004 | Yes |
| 3501 | 12396 | 1126.9 | 349.22 | 31.7 | International physical activity questionnaire: 12-country reliability and validity. | Cora L Craig, Alison L Marshall, Michael Sjöström, Adrian E Bauman, Michael L Booth, Barbara E Ainsworth, Michael Pratt, Ulf Ekelund, Agneta Yngve, James F Sallis, Pekka Oja | Med Sci Sports Exerc | 2003 | 12900694 | Yes |
| 3502 | 2253 | 1126.5 | 32.78 | 16.4 | Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. | L M Siegel, K J Monty | Biochim Biophys Acta | 1966 | 5329026 | Yes |
| 3503 | 4506 | 1126.5 | 108.08 | 27.0 | C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. | P M Ridker, C H Hennekens, J E Buring, N Rifai | N Engl J Med | 2000 | 10733371 | Yes |
| 3504 | 2253 | 1126.5 | 51.98 | 26.0 | The host defense of Drosophila melanogaster. | Bruno Lemaitre, Jules Hoffmann | Annu Rev Immunol | 2007 | 17201680 | No |
| 3505 | 2252 | 1126.0 | 38.84 | 19.4 | A synthetic oscillatory network of transcriptional regulators. | M B Elowitz, S Leibler | Nature | 2000 | 10659856 | Yes |
| 3506 | 1126 | 1126.0 | 27.94 | 27.9 | Seed Germination and Dormancy. | J. D. Bewley | Plant Cell | 1997 | 12237375 | Yes |
| 3507 | 2250 | 1125.0 | 48.88 | 24.4 | Regeneration beyond the glial scar. | Jerry Silver, Jared H Miller | Nat Rev Neurosci | 2004 | 14735117 | No |
| 3508 | 1125 | 1125.0 | 24.89 | 24.9 | Lithium batteries and cathode materials. | M Stanley Whittingham | Chem Rev | 2004 | 15669156 | Yes |
| 3509 | 1125 | 1125.0 | 34.91 | 34.9 | The collagen family. | Sylvie Ricard-Blum | Cold Spring Harb Perspect Biol | 2011 | 21421911 | No |
| 3510 | 4499 | 1124.8 | 103.71 | 25.9 | SCOP: a structural classification of proteins database for the investigation of sequences and structures. | A G Murzin, S E Brenner, T Hubbard, C Chothia | J Mol Biol | 1995 | 7723011 | Yes |
| 3511 | 5623 | 1124.6 | 301.9 | 60.4 | Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. | Daehwan Kim, Joseph M Paggi, Chanhee Park, Christopher Bennett, Steven L Salzberg | Nat Biotechnol | 2019 | 31375807 | Yes |
| 3512 | 2249 | 1124.5 | 80.86 | 40.4 | Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. | Claudio Franceschi, Judith Campisi | J Gerontol A Biol Sci Med Sci | 2014 | 24833586 | No |
| 3513 | 1124 | 1124.0 | 23.75 | 23.8 | Molecular cloning and expression of glycogen synthase kinase-3/factor A. | J R Woodgett | EMBO J | 1990 | 2164470 | Yes |
| 3514 | 1124 | 1124.0 | 45.07 | 45.1 | The anatomy of stages of change. | A Bandura | Am J Health Promot | 1997 | 10170438 | No |
| 3515 | 1124 | 1124.0 | 40.98 | 41.0 | Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms. | Tamás Rőszer | Mediators Inflamm | 2015 | 26089604 | No |
| 3516 | 3370 | 1123.3 | 78.48 | 26.2 | Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis. | Sang-Dong Yoo, Young-Hee Cho, Jen Sheen | Nat Protoc | 2007 | 17585298 | Yes |
| 3517 | 1123 | 1123.0 | 49.74 | 49.7 | Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. | S Z Langer | Br J Pharmacol | 1977 | 20190 | No |
| 3518 | 1123 | 1123.0 | 38.32 | 38.3 | Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. | A R Midgley | Endocrinology | 1966 | 5950482 | Yes |
| 3519 | 3369 | 1123.0 | 93.15 | 31.1 | Spirometric reference values from a sample of the general U.S. population. | J L Hankinson, J R Odencrantz, K B Fedan | Am J Respir Crit Care Med | 1999 | 9872837 | Yes |
| 3520 | 2245 | 1122.5 | 65.03 | 32.5 | Are the dorsal and ventral hippocampus functionally distinct structures? | Michael S Fanselow, Hong-Wei Dong | Neuron | 2010 | 20152109 | No |
| 3521 | 2244 | 1122.0 | 59.14 | 29.6 | Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. | R A Ignotz, J Massagué | J Biol Chem | 1986 | 3456347 | Yes |
| 3522 | 1122 | 1122.0 | 31.75 | 31.8 | Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. | S Irwin | Psychopharmacologia | 1968 | 5679627 | Yes |
| 3523 | 1122 | 1122.0 | 29.79 | 29.8 | The chromosomal basis of human neoplasia. | J J Yunis | Science | 1983 | 6336310 | Yes |
| 3524 | 1122 | 1122.0 | 32.84 | 32.8 | Cell surface interactions with extracellular materials. | K M Yamada | Annu Rev Biochem | 1983 | 6351729 | No |
| 3525 | 1122 | 1122.0 | 56.97 | 57.0 | Osseointegration and its experimental background. | P I Brånemark | J Prosthet Dent | 1983 | 6352924 | No |
| 3526 | 1122 | 1122.0 | 23.41 | 23.4 | ALSCRIPT: a tool to format multiple sequence alignments. | G J Barton | Protein Eng | 1993 | 8433969 | Yes |
| 3527 | 1122 | 1122.0 | 34.31 | 34.3 | Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. | P J Basser | NMR Biomed | 1995 | 8739270 | No |
| 3528 | 1122 | 1122.0 | 30.16 | 30.2 | What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. | Michael A Babyak | Psychosom Med | 2004 | 15184705 | Yes |
| 3529 | 1122 | 1122.0 | 26.04 | 26.0 | Solid-state nanopores. | Cees Dekker | Nat Nanotechnol | 2007 | 18654264 | No |
| 3530 | 11216 | 1121.6 | 253.45 | 25.3 | Scalable molecular dynamics with NAMD. | James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kalé, Klaus Schulten | J Comput Chem | 2005 | 16222654 | Yes |
| 3531 | 2243 | 1121.5 | 53.03 | 26.5 | Reducing the dimensionality of data with neural networks. | G E Hinton, R R Salakhutdinov | Science | 2006 | 16873662 | Yes |
| 3532 | 1121 | 1121.0 | 34.55 | 34.5 | Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. | J E Oesterling | J Urol | 1991 | 1707989 | No |
| 3533 | 2242 | 1121.0 | 45.03 | 22.5 | RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. | M B Shapiro, P Senapathy | Nucleic Acids Res | 1987 | 3658675 | Yes |
| 3534 | 1121 | 1121.0 | 30.99 | 31.0 | The locus coeruleus and noradrenergic modulation of cognition. | Susan J Sara | Nat Rev Neurosci | 2009 | 19190638 | No |
| 3535 | 3362 | 1120.7 | 77.26 | 25.8 | Obesity induces a phenotypic switch in adipose tissue macrophage polarization. | Carey N Lumeng, Jennifer L Bodzin, Alan R Saltiel | J Clin Invest | 2007 | 17200717 | Yes |
| 3536 | 1120 | 1120.0 | 39.66 | 39.7 | Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. | J N Wasserheit | Sex Transm Dis | 1992 | 1595015 | No |
| 3537 | 2240 | 1120.0 | 115.6 | 57.8 | The Neck Disability Index: a study of reliability and validity. | H Vernon, S Mior | J Manipulative Physiol Ther | 1991 | 1834753 | Yes |
| 3538 | 1120 | 1120.0 | 20.78 | 20.8 | The ubiquitin-proteasome pathway: on protein death and cell life. | A Ciechanover | EMBO J | 1998 | 9857172 | No |
| 3539 | 2240 | 1120.0 | 63.47 | 31.7 | Strategies in the design of nanoparticles for therapeutic applications. | Robby A Petros, Joseph M DeSimone | Nat Rev Drug Discov | 2010 | 20616808 | No |
| 3540 | 4478 | 1119.5 | 144.41 | 36.1 | The cholinergic hypothesis of geriatric memory dysfunction. | R T Bartus, R L Dean, B Beer, A S Lippa | Science | 1982 | 7046051 | No |
| 3541 | 2239 | 1119.5 | 58.83 | 29.4 | Oxidative stress, caloric restriction, and aging. | R S Sohal, R Weindruch | Science | 1996 | 8658196 | No |
| 3542 | 1119 | 1119.0 | 37.22 | 37.2 | Chemoprevention of cancer. | L W Wattenberg | Cancer Res | 1985 | 3880665 | No |
| 3543 | 1119 | 1119.0 | 36.82 | 36.8 | Socioeconomic disadvantage and child development. | V C McLoyd | Am Psychol | 1998 | 9491747 | No |
| 3544 | 1119 | 1119.0 | 23.75 | 23.8 | Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. | Michael Forgac | Nat Rev Mol Cell Biol | 2007 | 17912264 | No |
| 3545 | 1119 | 1119.0 | 29.31 | 29.3 | An introduction to data reduction: space-group determination, scaling and intensity statistics. | Philip R Evans | Acta Crystallogr D Biol Crystallogr | 2011 | 21460446 | Yes |
| 3546 | 1119 | 1119.0 | 71.82 | 71.8 | A network theory of mental disorders. | Denny Borsboom | World Psychiatry | 2017 | 28127906 | Yes |
| 3547 | 2237 | 1118.5 | 48.81 | 24.4 | Prediction of protein secondary structure at better than 70% accuracy. | B Rost, C Sander | J Mol Biol | 1993 | 8345525 | Yes |
| 3548 | 1118 | 1118.0 | 28.67 | 28.7 | Linkage strategies for genetically complex traits. I. Multilocus models. | N Risch | Am J Hum Genet | 1990 | 2301392 | Yes |
| 3549 | 1118 | 1118.0 | 34.64 | 34.6 | Protein damage and degradation by oxygen radicals. I. general aspects. | K J Davies | J Biol Chem | 1987 | 3036875 | Yes |
| 3550 | 1118 | 1118.0 | 26.15 | 26.1 | Differential projections of the infralimbic and prelimbic cortex in the rat. | Robert P Vertes | Synapse | 2004 | 14579424 | Yes |
| 3551 | 5589 | 1117.8 | 110.43 | 22.1 | Electrostatics of nanosystems: application to microtubules and the ribosome. | N A Baker, D Sept, S Joseph, M J Holst, J A McCammon | Proc Natl Acad Sci U S A | 2001 | 11517324 | Yes |
| 3552 | 2235 | 1117.5 | 49.7 | 24.9 | Synaptic activity and the construction of cortical circuits. | L C Katz, C J Shatz | Science | 1996 | 8895456 | No |
| 3553 | 1117 | 1117.0 | 33.06 | 33.1 | Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. | M J Gasson | J Bacteriol | 1983 | 6403500 | Yes |
| 3554 | 1117 | 1117.0 | 37.51 | 37.5 | A review of psychological risk factors in back and neck pain. | S J Linton | Spine (Phila Pa 1976) | 2000 | 10788861 | No |
| 3555 | 1117 | 1117.0 | 27.69 | 27.7 | Pathogenesis of osteoporosis: concepts, conflicts, and prospects. | Lawrence G Raisz | J Clin Invest | 2005 | 16322775 | No |
| 3556 | 6701 | 1116.8 | 175.36 | 29.2 | Prediction of coronary heart disease using risk factor categories. | P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B Kannel | Circulation | 1998 | 9603539 | Yes |
| 3557 | 3350 | 1116.7 | 81.88 | 27.3 | METAL: fast and efficient meta-analysis of genomewide association scans. | Cristen J Willer, Yun Li, Gonçalo R Abecasis | Bioinformatics | 2010 | 20616382 | Yes |
| 3558 | 2233 | 1116.5 | 44.86 | 22.4 | A survey of telomerase activity in human cancer. | J W Shay, S Bacchetti | Eur J Cancer | 1997 | 9282118 | No |
| 3559 | 1116 | 1116.0 | 32.73 | 32.7 | Animal mitochondrial DNA: structure and evolution. | D R Wolstenholme | Int Rev Cytol | 1992 | 1452431 | No |
| 3560 | 1116 | 1116.0 | 27.83 | 27.8 | Sex-hormone-binding globulin. | D C Anderson | Clin Endocrinol (Oxf) | 1974 | 4134992 | No |
| 3561 | 1115 | 1115.0 | 31.97 | 32.0 | Studies on histones. 7. Preparative methods for histone fractions from calf thymus. | E W Johns | Biochem J | 1964 | 5840387 | Yes |
| 3562 | 1115 | 1115.0 | 26.66 | 26.7 | Molecular drive: a cohesive mode of species evolution. | G Dover | Nature | 1982 | 7110332 | Yes |
| 3563 | 1115 | 1115.0 | 29.0 | 29.0 | Bile acids: regulation of synthesis. | John Y L Chiang | J Lipid Res | 2009 | 19346330 | No |
| 3564 | 2229 | 1114.5 | 58.17 | 29.1 | A rating scale for extrapyramidal side effects. | G M Simpson, J W Angus | Acta Psychiatr Scand Suppl | 1970 | 4917967 | Yes |
| 3565 | 2229 | 1114.5 | 58.61 | 29.3 | Localized surface plasmon resonance spectroscopy and sensing. | Katherine A Willets, Richard P Van Duyne | Annu Rev Phys Chem | 2007 | 17067281 | No |
| 3566 | 4457 | 1114.2 | 34.1 | 8.5 | The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. | P J Randle, P B Garland, C N Hales, E A Newsholme | Lancet | 1963 | 13990765 | Yes |
| 3567 | 1114 | 1114.0 | 52.37 | 52.4 | Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. | Y Kono | Arch Biochem Biophys | 1978 | 24422 | Yes |
| 3568 | 1114 | 1114.0 | 26.58 | 26.6 | ImageJ for microscopy. | Tony J Collins | Biotechniques | 2007 | 17936939 | No |
| 3569 | 2227 | 1113.5 | 47.5 | 23.8 | Finding and evaluating community structure in networks. | M E J Newman, M Girvan | Phys Rev E Stat Nonlin Soft Matter Phys | 2004 | 14995526 | Yes |
| 3570 | 1113 | 1113.0 | 25.62 | 25.6 | Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis. | M M Tirion | Phys Rev Lett | 1996 | 10063201 | Yes |
| 3571 | 4452 | 1113.0 | 116.83 | 29.2 | Prevalence and trends in obesity among US adults, 1999-2000. | Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L Johnson | JAMA | 2002 | 12365955 | Yes |
| 3572 | 1113 | 1113.0 | 29.36 | 29.4 | Abiotic stress, the field environment and stress combination. | Ron Mittler | Trends Plant Sci | 2006 | 16359910 | No |
| 3573 | 1113 | 1113.0 | 22.82 | 22.8 | Membrane recognition by phospholipid-binding domains. | Mark A Lemmon | Nat Rev Mol Cell Biol | 2008 | 18216767 | No |
| 3574 | 2226 | 1113.0 | 236.03 | 118.0 | Mental Health and the Covid-19 Pandemic. | Betty Pfefferbaum, Carol S North | N Engl J Med | 2020 | 32283003 | Yes |
| 3575 | 1112 | 1112.0 | 54.64 | 54.6 | The sociological study of stress. | L I Pearlin | J Health Soc Behav | 1989 | 2674272 | No |
| 3576 | 3336 | 1112.0 | 157.89 | 52.6 | Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG) | P L Hudak, P C Amadio, C Bombardier | Am J Ind Med | 1996 | 8773720 | Yes |
| 3577 | 2224 | 1112.0 | 49.89 | 24.9 | A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. | J N Cohn, G Tognoni | N Engl J Med | 2001 | 11759645 | Yes |
| 3578 | 1112 | 1112.0 | 21.03 | 21.0 | Focal adhesion kinase: the first ten years. | J Thomas Parsons | J Cell Sci | 2003 | 12640026 | No |
| 3579 | 1112 | 1112.0 | 33.07 | 33.1 | Social support and patient adherence to medical treatment: a meta-analysis. | M Robin DiMatteo | Health Psychol | 2004 | 15008666 | Yes |
| 3580 | 2224 | 1112.0 | 48.35 | 24.2 | Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. | Daniel J Hicklin, Lee M Ellis | J Clin Oncol | 2005 | 15585754 | No |
| 3581 | 1112 | 1112.0 | 24.27 | 24.3 | Personal genomes: The case of the missing heritability. | Brendan Maher | Nature | 2008 | 18987709 | No |
| 3582 | 1112 | 1112.0 | 38.51 | 38.5 | Epidemiology of heart failure. | Véronique L Roger | Circ Res | 2013 | 23989710 | No |
| 3583 | 2223 | 1111.5 | 69.57 | 34.8 | Excitatory amino acid transmitters. | J C Watkins, R H Evans | Annu Rev Pharmacol Toxicol | 1981 | 6112965 | No |
| 3584 | 2222 | 1111.0 | 51.94 | 26.0 | Cellular uptake of the tat protein from human immunodeficiency virus. | A D Frankel, C O Pabo | Cell | 1988 | 2849510 | Yes |
| 3585 | 1111 | 1111.0 | 23.63 | 23.6 | Complement. Second of two parts. | M J Walport | N Engl J Med | 2001 | 11297706 | No |
| 3586 | 1111 | 1111.0 | 24.7 | 24.7 | Current concepts of the pathogenesis of the acute coronary syndromes. | P Libby | Circulation | 2001 | 11457759 | No |
| 3587 | 1111 | 1111.0 | 24.11 | 24.1 | Toward self-organization and complex matter. | Jean-Marie Lehn | Science | 2002 | 11923524 | Yes |
| 3588 | 1111 | 1111.0 | 0.0 | 0.0 | A cytoarchitectonic atlas of the spinal cord in the cat. | B Rexed | J Comp Neurol | 1954 | 13163236 | Yes |
| 3589 | 2222 | 1111.0 | 77.17 | 38.6 | Microdroplet Assay Of Human Serum Cytotoxins. | P I Terasaki, J D Mcclelland | Nature | 1964 | 14248725 | Yes |
| 3590 | 2222 | 1111.0 | 66.47 | 33.2 | Reactive oxygen species, cellular redox systems, and apoptosis. | Magdalena L Circu, Tak Yee Aw | Free Radic Biol Med | 2010 | 20045723 | No |
| 3591 | 2221 | 1110.5 | 64.92 | 32.5 | Chronic hepatitis B: update 2009. | Anna S F Lok, Brian J McMahon | Hepatology | 2009 | 19714720 | Yes |
| 3592 | 1110 | 1110.0 | 43.57 | 43.6 | A simple method for determination of serum catalase activity and revision of reference range. | L Góth | Clin Chim Acta | 1991 | 2029780 | Yes |
| 3593 | 1110 | 1110.0 | 19.8 | 19.8 | Cell lines derived from late embryonic stages of Drosophila melanogaster. | I Schneider | J Embryol Exp Morphol | 1972 | 4625067 | Yes |
| 3594 | 1110 | 1110.0 | 40.1 | 40.1 | Methods for dealing with reaction time outliers. | R Ratcliff | Psychol Bull | 1993 | 8272468 | Yes |
| 3595 | 1110 | 1110.0 | 29.01 | 29.0 | Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. | F P Guengerich | Chem Res Toxicol | 2001 | 11409933 | No |
| 3596 | 2219 | 1109.5 | 34.23 | 17.1 | Construction of phylogenetic trees. | W M Fitch, E Margoliash | Science | 1967 | 5334057 | No |
| 3597 | 2218 | 1109.0 | 71.62 | 35.8 | Wine, alcohol, platelets, and the French paradox for coronary heart disease. | S Renaud, M de Lorgeril | Lancet | 1992 | 1351198 | Yes |
| 3598 | 1109 | 1109.0 | 21.81 | 21.8 | Cytokine receptor signalling. | J N Ihle | Nature | 1995 | 7566171 | No |
| 3599 | 1109 | 1109.0 | 23.04 | 23.0 | Phenotypic plasticity and the epigenetics of human disease. | Andrew P Feinberg | Nature | 2007 | 17522677 | No |
| 3600 | 2217 | 1108.5 | 54.12 | 27.1 | Quorum sensing: cell-to-cell communication in bacteria. | Christopher M Waters, Bonnie L Bassler | Annu Rev Cell Dev Biol | 2005 | 16212498 | No |
| 3601 | 11083 | 1108.3 | 364.8 | 36.5 | The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. | N K Aaronson, S Ahmedzai, B Bergman, M Bullinger, A Cull, N J Duez, A Filiberti, H Flechtner, S B Fleishman, J C de Haes | J Natl Cancer Inst | 1993 | 8433390 | Yes |
| 3602 | 1108 | 1108.0 | 38.68 | 38.7 | Spin trapping: ESR parameters of spin adducts. | G R Buettner | Free Radic Biol Med | 1987 | 2826304 | No |
| 3603 | 2216 | 1108.0 | 54.34 | 27.2 | Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. | R J Britten, D E Kohne | Science | 1968 | 4874239 | Yes |
| 3604 | 3324 | 1108.0 | 86.44 | 28.8 | Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. | M K Parmar, V Torri, L Stewart | Stat Med | 1998 | 9921604 | Yes |
| 3605 | 1108 | 1108.0 | 23.37 | 23.4 | Twilight zone of protein sequence alignments. | B Rost | Protein Eng | 1999 | 10195279 | Yes |
| 3606 | 1108 | 1108.0 | 24.61 | 24.6 | The impact of next-generation sequencing technology on genetics. | Elaine R Mardis | Trends Genet | 2008 | 18262675 | No |
| 3607 | 1107 | 1107.0 | 56.71 | 56.7 | The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. | G A Ilizarov | Clin Orthop Relat Res | 1989 | 2912628 | Yes |
| 3608 | 3320 | 1106.7 | 112.13 | 37.4 | Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. | M Hamberg, J Svensson, B Samuelsson | Proc Natl Acad Sci U S A | 1975 | 1059088 | Yes |
| 3609 | 2213 | 1106.5 | 90.21 | 45.1 | AKT/PKB Signaling: Navigating the Network. | Brendan D Manning, Alex Toker | Cell | 2017 | 28431241 | No |
| 3610 | 2212 | 1106.0 | 104.42 | 52.2 | Problems and proposals for recording gingivitis and plaque. | J Ainamo, I Bay | Int Dent J | 1975 | 1058834 | Yes |
| 3611 | 1106 | 1106.0 | 22.19 | 22.2 | Primary response genes induced by growth factors and tumor promoters. | H R Herschman | Annu Rev Biochem | 1991 | 1883198 | No |
| 3612 | 1106 | 1106.0 | 26.31 | 26.3 | Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. | Thomas A Wynn | J Clin Invest | 2007 | 17332879 | No |
| 3613 | 2211 | 1105.5 | 51.49 | 25.7 | T antigen is bound to a host protein in SV40-transformed cells. | D P Lane, L V Crawford | Nature | 1979 | 218111 | Yes |
| 3614 | 1105 | 1105.0 | 23.15 | 23.1 | A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. | J Milbrandt | Science | 1987 | 3672127 | Yes |
| 3615 | 1105 | 1105.0 | 27.43 | 27.4 | The Trk family of neurotrophin receptors. | M Barbacid | J Neurobiol | 1994 | 7852993 | No |
| 3616 | 1105 | 1105.0 | 26.45 | 26.4 | Cells in stress: transcriptional activation of heat shock genes. | R I Morimoto | Science | 1993 | 8451637 | No |
| 3617 | 1105 | 1105.0 | 21.21 | 21.2 | Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. | A S Baldwin | J Clin Invest | 2001 | 11160144 | No |
| 3618 | 1104 | 1104.0 | 75.67 | 75.7 | Root canal anatomy of the human permanent teeth. | F J Vertucci | Oral Surg Oral Med Oral Pathol | 1984 | 6595621 | Yes |
| 3619 | 1104 | 1104.0 | 0.0 | 0.0 | Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins. | R D Owen | Science | 1945 | 17755278 | Yes |
| 3620 | 3312 | 1104.0 | 88.6 | 29.5 | Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation. | Davis J McCarthy, Yunshun Chen, Gordon K Smyth | Nucleic Acids Res | 2012 | 22287627 | Yes |
| 3621 | 3311 | 1103.7 | 118.43 | 39.5 | Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. | P S Walsh, D A Metzger, R Higuchi | Biotechniques | 1991 | 1867860 | Yes |
| 3622 | 1103 | 1103.0 | 59.11 | 59.1 | The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement. | M M Panjabi | J Spinal Disord | 1992 | 1490034 | Yes |
| 3623 | 1103 | 1103.0 | 20.3 | 20.3 | Chronic myeloid leukemia. | C L Sawyers | N Engl J Med | 1999 | 10219069 | No |
| 3624 | 1103 | 1103.0 | 25.23 | 25.2 | The prefrontal cortex--an update: time is of the essence. | J M Fuster | Neuron | 2001 | 11394996 | No |
| 3625 | 1103 | 1103.0 | 22.22 | 22.2 | Osmotic stress signaling and osmoadaptation in yeasts. | Stefan Hohmann | Microbiol Mol Biol Rev | 2002 | 12040128 | No |
| 3626 | 1102 | 1102.0 | 28.02 | 28.0 | Glutathione and its role in cellular functions. | H Sies | Free Radic Biol Med | 1999 | 10569624 | No |
| 3627 | 1102 | 1102.0 | 19.94 | 19.9 | Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. | R A Frye | Biochem Biophys Res Commun | 2000 | 10873683 | Yes |
| 3628 | 1102 | 1102.0 | 28.08 | 28.1 | Unequal treatment: confronting racial and ethnic disparities in health care. | Alan Nelson | J Natl Med Assoc | 2002 | 12152921 | No |
| 3629 | 2204 | 1102.0 | 0.0 | 0.0 | Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. | A H Coons, M H Kaplan | J Exp Med | 1950 | 15395569 | Yes |
| 3630 | 4408 | 1102.0 | 146.63 | 36.7 | Prevalence and trends in obesity among US adults, 1999-2008. | Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R Curtin | JAMA | 2010 | 20071471 | Yes |
| 3631 | 2203 | 1101.5 | 100.8 | 50.4 | Organic Photoredox Catalysis. | Nathan A Romero, David A Nicewicz | Chem Rev | 2016 | 27285582 | Yes |
| 3632 | 1101 | 1101.0 | 0.0 | 0.0 | The stereotaxic method and radiosurgery of the brain. | L Leksell | Acta Chir Scand | 1951 | 14914373 | Yes |
| 3633 | 2202 | 1101.0 | 117.46 | 58.7 | Sexually transmitted diseases treatment guidelines, 2015. | Kimberly A Workowski, Gail A Bolan | MMWR Recomm Rep | 2015 | 26042815 | No |
| 3634 | 4402 | 1100.5 | 253.22 | 63.3 | Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads. | Ryan R Wick, Louise M Judd, Claire L Gorrie, Kathryn E Holt | PLoS Comput Biol | 2017 | 28594827 | Yes |
| 3635 | 1100 | 1100.0 | 33.65 | 33.6 | Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. | D L Coleman | Diabetologia | 1978 | 350680 | No |
| 3636 | 1100 | 1100.0 | 24.42 | 24.4 | The molecular biology of leukocyte chemoattractant receptors. | P M Murphy | Annu Rev Immunol | 1994 | 8011292 | No |
| 3637 | 1100 | 1100.0 | 26.19 | 26.2 | Quantification of beta-sheet amyloid fibril structures with thioflavin T. | H LeVine | Methods Enzymol | 1999 | 10507030 | Yes |
| 3638 | 2200 | 1100.0 | 44.05 | 22.0 | Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. | P E Wright, H J Dyson | J Mol Biol | 1999 | 10550212 | No |
| 3639 | 5500 | 1100.0 | 149.03 | 29.8 | Biodiversity hotspots for conservation priorities. | N Myers, R A Mittermeier, C G Mittermeier, G A da Fonseca, J Kent | Nature | 2000 | 10706275 | Yes |
| 3640 | 1100 | 1100.0 | 27.84 | 27.8 | Redefining oxidative stress. | Dean P Jones | Antioxid Redox Signal | 2006 | 16987039 | No |
| 3641 | 1100 | 1100.0 | 0.0 | 0.0 | Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent. | D L Morris | Science | 1948 | 17814729 | Yes |
| 3642 | 1100 | 1100.0 | 45.38 | 45.4 | A comprehensive review on metabolic syndrome. | Jaspinder Kaur | Cardiol Res Pract | 2014 | 24711954 | No |
| 3643 | 6597 | 1099.5 | 211.26 | 35.2 | The Molecular Signatures Database (MSigDB) hallmark gene set collection. | Arthur Liberzon, Chet Birger, Helga Thorvaldsdóttir, Mahmoud Ghandi, Jill P Mesirov, Pablo Tamayo | Cell Syst | 2015 | 26771021 | Yes |
| 3644 | 2198 | 1099.0 | 65.76 | 32.9 | Mental rotation of three-dimensional objects. | R N Shepard, J Metzler | Science | 1971 | 5540314 | Yes |
| 3645 | 1099 | 1099.0 | 27.42 | 27.4 | A kinetic photometric method for serum gamma-glutamyl transpeptidase. | G Szasz | Clin Chem | 1969 | 5773262 | Yes |
| 3646 | 1099 | 1099.0 | 24.66 | 24.7 | Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system. | T Ikemura | J Mol Biol | 1981 | 6175758 | Yes |
| 3647 | 1099 | 1099.0 | 28.86 | 28.9 | Philosophical conceptions of the self: implications for cognitive science. | I Gallagher | Trends Cogn Sci | 2000 | 10637618 | Yes |
| 3648 | 1099 | 1099.0 | 43.89 | 43.9 | Likert scales, levels of measurement and the "laws" of statistics. | Geoff Norman | Adv Health Sci Educ Theory Pract | 2010 | 20146096 | Yes |
| 3649 | 2198 | 1099.0 | 90.79 | 45.4 | The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities. | Samuel Genheden, Ulf Ryde | Expert Opin Drug Discov | 2015 | 25835573 | No |
| 3650 | 2197 | 1098.5 | 48.89 | 24.4 | Cell cycle control and cancer. | L H Hartwell, M B Kastan | Science | 1994 | 7997877 | No |
| 3651 | 2197 | 1098.5 | 27.1 | 13.6 | Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques. | P Gold, S O Freedman | J Exp Med | 1965 | 14270243 | Yes |
| 3652 | 1098 | 1098.0 | 27.69 | 27.7 | Two distinct classes of carbohydrate-recognition domains in animal lectins. | K Drickamer | J Biol Chem | 1988 | 3290208 | No |
| 3653 | 3294 | 1098.0 | 129.53 | 43.2 | Concurrent and predictive validity of a self-reported measure of medication adherence. | D E Morisky, L W Green, D M Levine | Med Care | 1986 | 3945130 | Yes |
| 3654 | 1098 | 1098.0 | 42.3 | 42.3 | The role of endothelium in the responses of vascular smooth muscle to drugs. | R F Furchgott | Annu Rev Pharmacol Toxicol | 1984 | 6203480 | No |
| 3655 | 1098 | 1098.0 | 25.43 | 25.4 | BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data. | O Gascuel | Mol Biol Evol | 1997 | 9254330 | Yes |
| 3656 | 2196 | 1098.0 | 44.85 | 22.4 | The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. | A Bairoch, R Apweiler | Nucleic Acids Res | 2000 | 10592178 | Yes |
| 3657 | 1098 | 1098.0 | 0.0 | 0.0 | Cleavage of the haem-protein link by acid methylethylketone. | F W Teale | Biochim Biophys Acta | 1959 | 13837237 | Yes |
| 3658 | 1098 | 1098.0 | 0.0 | 0.0 | Motivation reconsidered: the concept of competence. | R W White | Psychol Rev | 1959 | 13844397 | Yes |
| 3659 | 2196 | 1098.0 | 53.53 | 26.8 | Sulforhodamine B colorimetric assay for cytotoxicity screening. | Vanicha Vichai, Kanyawim Kirtikara | Nat Protoc | 2006 | 17406391 | Yes |
| 3660 | 1098 | 1098.0 | 29.92 | 29.9 | Principles of c-di-GMP signalling in bacteria. | Regine Hengge | Nat Rev Microbiol | 2009 | 19287449 | No |
| 3661 | 2195 | 1097.5 | 55.19 | 27.6 | Antibacterial resistance worldwide: causes, challenges and responses. | Stuart B Levy, Bonnie Marshall | Nat Med | 2004 | 15577930 | No |
| 3662 | 1097 | 1097.0 | 30.34 | 30.3 | Transport of molecules in the tumor interstitium: a review. | R K Jain | Cancer Res | 1987 | 3555767 | No |
| 3663 | 1097 | 1097.0 | 32.55 | 32.5 | Tests for emotionality in rats and mice: a review. | J Archer | Anim Behav | 1973 | 4578750 | No |
| 3664 | 2194 | 1097.0 | 45.49 | 22.7 | p53: puzzle and paradigm. | L J Ko, C Prives | Genes Dev | 1996 | 8654922 | No |
| 3665 | 1097 | 1097.0 | 0.0 | 0.0 | Asymptomatic infections of the urinary tract. | E H Kass | Trans Assoc Am Physicians | 1956 | 13380946 | Yes |
| 3666 | 1097 | 1097.0 | 34.22 | 34.2 | Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. | Jeffrey N Katz | J Bone Joint Surg Am | 2006 | 16595438 | No |
| 3667 | 1097 | 1097.0 | 31.36 | 31.4 | Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. | Gregg L Semenza | Trends Pharmacol Sci | 2012 | 22398146 | No |
| 3668 | 6580 | 1096.7 | 168.8 | 28.1 | The capsaicin receptor: a heat-activated ion channel in the pain pathway. | M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D Julius | Nature | 1997 | 9349813 | Yes |
| 3669 | 3290 | 1096.7 | 68.85 | 22.9 | 5-fluorouracil: mechanisms of action and clinical strategies. | Daniel B Longley, D Paul Harkin, Patrick G Johnston | Nat Rev Cancer | 2003 | 12724731 | No |
| 3670 | 2193 | 1096.5 | 0.0 | 0.0 | Cortisone in ulcerative colitis; final report on a therapeutic trial. | S C Truelove, L J Witts | Br Med J | 1955 | 13260656 | Yes |
| 3671 | 2193 | 1096.5 | 0.0 | 0.0 | Micromethod for the direct determination of serum triglycerides. | E Van Handel, D B Zilversmit | J Lab Clin Med | 1957 | 13439279 | Yes |
| 3672 | 2192 | 1096.0 | 82.78 | 41.4 | Visual search and stimulus similarity. | J Duncan, G W Humphreys | Psychol Rev | 1989 | 2756067 | Yes |
| 3673 | 1096 | 1096.0 | 22.45 | 22.4 | mRNA stability in mammalian cells. | J Ross | Microbiol Rev | 1995 | 7565413 | No |
| 3674 | 1096 | 1096.0 | 33.93 | 33.9 | The oxidation hypothesis of atherosclerosis. | J L Witztum | Lancet | 1994 | 7916078 | No |
| 3675 | 2192 | 1096.0 | 50.13 | 25.1 | Hepatitis C virus infection. | G M Lauer, B D Walker | N Engl J Med | 2001 | 11439948 | No |
| 3676 | 2192 | 1096.0 | 61.17 | 30.6 | ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control. | Graham Noctor, Christine H. Foyer | Annu Rev Plant Physiol Plant Mol Biol | 1998 | 15012235 | Yes |
| 3677 | 2191 | 1095.5 | 82.57 | 41.3 | Understanding face recognition. | V Bruce, A Young | Br J Psychol | 1986 | 3756376 | Yes |
| 3678 | 1095 | 1095.0 | 20.69 | 20.7 | Luciferase reporter gene vectors for analysis of promoters and enhancers. | S K Nordeen | Biotechniques | 1988 | 2908509 | Yes |
| 3679 | 2190 | 1095.0 | 65.68 | 32.8 | 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. | A Poland, J C Knutson | Annu Rev Pharmacol Toxicol | 1982 | 6282188 | No |
| 3680 | 2190 | 1095.0 | 63.33 | 31.7 | The acute phase response. | H Baumann, J Gauldie | Immunol Today | 1994 | 7512342 | No |
| 3681 | 1095 | 1095.0 | 32.32 | 32.3 | Spatially heterogeneous dynamics in supercooled liquids. | M D Ediger | Annu Rev Phys Chem | 2000 | 11031277 | Yes |
| 3682 | 2189 | 1094.5 | 77.11 | 38.6 | Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. | A I Basbaum, H L Fields | Annu Rev Neurosci | 1984 | 6143527 | No |
| 3683 | 1094 | 1094.0 | 39.49 | 39.5 | Attention, similarity, and the identification-categorization relationship. | R M Nosofsky | J Exp Psychol Gen | 1986 | 2937873 | Yes |
| 3684 | 1094 | 1094.0 | 28.02 | 28.0 | Neuropathology of Parkinson's disease. | L S Forno | J Neuropathol Exp Neurol | 1996 | 8786384 | No |
| 3685 | 1094 | 1094.0 | 29.43 | 29.4 | Interval estimation for the difference between independent proportions: comparison of eleven methods. | R G Newcombe | Stat Med | 1998 | 9595617 | Yes |
| 3686 | 1094 | 1094.0 | 27.61 | 27.6 | Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. | Betsy Foxman | Am J Med | 2002 | 12113866 | No |
| 3687 | 1094 | 1094.0 | 27.28 | 27.3 | Fibrinogen and fibrin structure and functions. | M W Mosesson | J Thromb Haemost | 2005 | 16102057 | No |
| 3688 | 2188 | 1094.0 | 61.12 | 30.6 | Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. | Amit Etkin, Tor D Wager | Am J Psychiatry | 2007 | 17898336 | Yes |
| 3689 | 2188 | 1094.0 | 90.02 | 45.0 | Using Effect Size-or Why the P Value Is Not Enough. | Gail M Sullivan, Richard Feinn | J Grad Med Educ | 2012 | 23997866 | Yes |
| 3690 | 1093 | 1093.0 | 19.55 | 19.6 | Time-dependent processes in memory storage. | J L McGaugh | Science | 1966 | 5917768 | Yes |
| 3691 | 1093 | 1093.0 | 0.0 | 0.0 | The purine and pyrimidine composition of deoxypentose nucleic acids. | G R Wyatt | Biochem J | 1951 | 14838906 | Yes |
| 3692 | 5464 | 1092.8 | 114.73 | 22.9 | The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. | J W Harper, G R Adami, N Wei, K Keyomarsi, S J Elledge | Cell | 1993 | 8242751 | Yes |
| 3693 | 3276 | 1092.0 | 98.01 | 32.7 | Depression: a new animal model sensitive to antidepressant treatments. | R D Porsolt, M Le Pichon, M Jalfre | Nature | 1977 | 559941 | Yes |
| 3694 | 1092 | 1092.0 | 29.82 | 29.8 | Aging, energy, and oxidative stress in neurodegenerative diseases. | M F Beal | Ann Neurol | 1995 | 7668820 | No |
| 3695 | 1092 | 1092.0 | 25.31 | 25.3 | Selectins and their ligands: current concepts and controversies. | G S Kansas | Blood | 1996 | 8896391 | No |
| 3696 | 1092 | 1092.0 | 22.67 | 22.7 | Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. | Z Yang | Mol Biol Evol | 1998 | 9580986 | Yes |
| 3697 | 1092 | 1092.0 | 0.0 | 0.0 | The effect of emotion on cue utilization and the organization of behavior. | J A Easterbrook | Psychol Rev | 1959 | 13658305 | Yes |
| 3698 | 2184 | 1092.0 | 75.71 | 37.9 | Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. | Hirenkumar K Makadia, Steven J Siegel | Polymers (Basel) | 2011 | 22577513 | Yes |
| 3699 | 1092 | 1092.0 | 49.69 | 49.7 | Cystic fibrosis. | J Stuart Elborn | Lancet | 2016 | 27140670 | No |
| 3700 | 5456 | 1091.2 | 164.15 | 32.8 | Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. | Salim Yusuf, Bertram Pitt, Clarence E Davis, William B Hood, Jay N Cohn | N Engl J Med | 1991 | 2057034 | Yes |
| 3701 | 1091 | 1091.0 | 30.65 | 30.6 | Limbic-cortical dysregulation: a proposed model of depression. | H S Mayberg | J Neuropsychiatry Clin Neurosci | 1997 | 9276848 | No |
| 3702 | 2182 | 1091.0 | 40.03 | 20.0 | AP-1 as a regulator of cell life and death. | Eitan Shaulian, Michael Karin | Nat Cell Biol | 2002 | 11988758 | No |
| 3703 | 2182 | 1091.0 | 61.73 | 30.9 | Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. | Ivan Sondi, Branka Salopek-Sondi | J Colloid Interface Sci | 2004 | 15158396 | Yes |
| 3704 | 1091 | 1091.0 | 24.3 | 24.3 | Liver regeneration. | George K Michalopoulos | J Cell Physiol | 2007 | 17559071 | No |
| 3705 | 1091 | 1091.0 | 28.88 | 28.9 | Neuronal gamma-band synchronization as a fundamental process in cortical computation. | Pascal Fries | Annu Rev Neurosci | 2009 | 19400723 | No |
| 3706 | 1091 | 1091.0 | 33.39 | 33.4 | Lanthanide luminescence for biomedical analyses and imaging. | Jean-Claude G Bünzli | Chem Rev | 2010 | 20151630 | No |
| 3707 | 2181 | 1090.5 | 45.55 | 22.8 | The Hsp70 and Hsp60 chaperone machines. | B Bukau, A L Horwich | Cell | 1998 | 9476895 | No |
| 3708 | 1090 | 1090.0 | 26.71 | 26.7 | DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. | J F Ward | Prog Nucleic Acid Res Mol Biol | 1988 | 3065826 | No |
| 3709 | 1090 | 1090.0 | 19.85 | 19.9 | Protein denaturation. C. Theoretical models for the mechanism of denaturation. | C Tanford | Adv Protein Chem | 1970 | 4912353 | No |
| 3710 | 1090 | 1090.0 | 30.36 | 30.4 | On the utility of P3 amplitude as a measure of processing capacity. | A Kok | Psychophysiology | 2001 | 11352145 | No |
| 3711 | 1090 | 1090.0 | 24.86 | 24.9 | Structure and signalling in the IL-17 receptor family. | Sarah L Gaffen | Nat Rev Immunol | 2009 | 19575028 | No |
| 3712 | 1089 | 1089.0 | 63.43 | 63.4 | The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture. | J Cassel | Am J Epidemiol | 1976 | 782233 | No |
| 3713 | 2178 | 1089.0 | 98.61 | 49.3 | Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. | J B Mulliken, J Glowacki | Plast Reconstr Surg | 1982 | 7063565 | Yes |
| 3714 | 1089 | 1089.0 | 21.53 | 21.5 | Coiled coils: new structures and new functions. | A Lupas | Trends Biochem Sci | 1996 | 8918191 | No |
| 3715 | 1089 | 1089.0 | 23.86 | 23.9 | New ideas about atrial fibrillation 50 years on. | Stanley Nattel | Nature | 2002 | 11805846 | No |
| 3716 | 1089 | 1089.0 | 21.31 | 21.3 | Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution. | Mats G L Gustafsson | Proc Natl Acad Sci U S A | 2005 | 16141335 | Yes |
| 3717 | 2178 | 1089.0 | 70.66 | 35.3 | Prostaglandins and inflammation. | Emanuela Ricciotti, Garret A FitzGerald | Arterioscler Thromb Vasc Biol | 2011 | 21508345 | No |
| 3718 | 6533 | 1088.8 | 158.87 | 26.5 | Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. | S Yusuf, P Sleight, J Pogue, J Bosch, R Davies, G Dagenais | N Engl J Med | 2000 | 10639539 | Yes |
| 3719 | 4353 | 1088.2 | 158.71 | 39.7 | Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. | K F Schulz, I Chalmers, R J Hayes, D G Altman | JAMA | 1995 | 7823387 | Yes |
| 3720 | 1088 | 1088.0 | 36.18 | 36.2 | Why we need observational studies to evaluate the effectiveness of health care. | N Black | BMJ | 1996 | 8634569 | Yes |
| 3721 | 1088 | 1088.0 | 25.13 | 25.1 | P-450 metabolites of arachidonic acid in the control of cardiovascular function. | Richard J Roman | Physiol Rev | 2002 | 11773611 | No |
| 3722 | 1088 | 1088.0 | 20.66 | 20.7 | mTOR and cancer: insights into a complex relationship. | David M Sabatini | Nat Rev Cancer | 2006 | 16915295 | No |
| 3723 | 1088 | 1088.0 | 0.0 | 0.0 | Aniline hydrogen phthalate as a spraying reagent for chromatography of sugars. | S M Partridge | Nature | 1949 | 18140444 | Yes |
| 3724 | 1088 | 1088.0 | 23.39 | 23.4 | Serine/threonine phosphatases: mechanism through structure. | Yigong Shi | Cell | 2009 | 19879837 | No |
| 3725 | 2174 | 1087.0 | 68.09 | 34.0 | Glutamate and the pathophysiology of hypoxic--ischemic brain damage. | S M Rothman, J W Olney | Ann Neurol | 1986 | 2421636 | No |
| 3726 | 1087 | 1087.0 | 20.57 | 20.6 | At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. | M Kozak | J Mol Biol | 1987 | 3681984 | Yes |
| 3727 | 1087 | 1087.0 | 36.34 | 36.3 | Lipid peroxidation and antioxidants as biomarkers of tissue damage. | J M Gutteridge | Clin Chem | 1995 | 7497639 | No |
| 3728 | 1087 | 1087.0 | 40.93 | 40.9 | Beyond curriculum reform: confronting medicine's hidden curriculum. | F W Hafferty | Acad Med | 1998 | 9580717 | Yes |
| 3729 | 1087 | 1087.0 | 25.45 | 25.4 | Nitric oxide, oxidants, and protein tyrosine nitration. | Rafael Radi | Proc Natl Acad Sci U S A | 2004 | 15020765 | Yes |
| 3730 | 1087 | 1087.0 | 28.37 | 28.4 | Physiology and immunology of the cholinergic antiinflammatory pathway. | Kevin J Tracey | J Clin Invest | 2007 | 17273548 | No |
| 3731 | 1087 | 1087.0 | 42.45 | 42.5 | Intention-to-treat concept: A review. | Sandeep K Gupta | Perspect Clin Res | 2011 | 21897887 | Yes |
| 3732 | 2173 | 1086.5 | 0.0 | 0.0 | A revision of the Schoenheimer-Sperry method for cholesterol determination. | W M Sperry, M Webb | J Biol Chem | 1950 | 14794694 | Yes |
| 3733 | 1086 | 1086.0 | 37.39 | 37.4 | Multiple organ failure. Pathophysiology and potential future therapy. | E A Deitch | Ann Surg | 1992 | 1503516 | No |
| 3734 | 1086 | 1086.0 | 23.88 | 23.9 | The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion. | S Roseman | Chem Phys Lipids | 1970 | 5476326 | Yes |
| 3735 | 1086 | 1086.0 | 28.68 | 28.7 | Invited review: Aging and sarcopenia. | Timothy J Doherty | J Appl Physiol (1985) | 2003 | 12970377 | No |
| 3736 | 2172 | 1086.0 | 74.16 | 37.1 | Mendelian randomization: genetic anchors for causal inference in epidemiological studies. | George Davey Smith, Gibran Hemani | Hum Mol Genet | 2014 | 25064373 | No |
| 3737 | 1085 | 1085.0 | 18.74 | 18.7 | Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. | R Rothstein | Methods Enzymol | 1991 | 2005793 | Yes |
| 3738 | 1085 | 1085.0 | 22.5 | 22.5 | T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. | R H Schwartz | Annu Rev Immunol | 1985 | 2415139 | No |
| 3739 | 1085 | 1085.0 | 23.85 | 23.9 | Molecular mechanisms of myocardial remodeling. | B Swynghedauw | Physiol Rev | 1999 | 9922372 | No |
| 3740 | 1085 | 1085.0 | 33.06 | 33.1 | On the mechanisms of biocompatibility. | David F Williams | Biomaterials | 2008 | 18440630 | No |
| 3741 | 2169 | 1084.5 | 65.28 | 32.6 | A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. | J J Sedmak, S E Grossberg | Anal Biochem | 1977 | 68686 | Yes |
| 3742 | 2168 | 1084.0 | 50.84 | 25.4 | Peroxidase-labeled antibody. A new method of conjugation. | P K Nakane, A Kawaoi | J Histochem Cytochem | 1974 | 4443551 | Yes |
| 3743 | 1084 | 1084.0 | 45.14 | 45.1 | Corticosteroids and lymphoid cells. | H N Claman | N Engl J Med | 1972 | 5043524 | Yes |
| 3744 | 3251 | 1083.7 | 63.03 | 21.0 | Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. | Paola Scaffidi, Tom Misteli, Marco E Bianchi | Nature | 2002 | 12110890 | Yes |
| 3745 | 2167 | 1083.5 | 54.75 | 27.4 | Anemia of chronic disease. | Guenter Weiss, Lawrence T Goodnough | N Engl J Med | 2005 | 15758012 | No |
| 3746 | 2167 | 1083.5 | 62.32 | 31.2 | Accurate and robust brain image alignment using boundary-based registration. | Douglas N Greve, Bruce Fischl | Neuroimage | 2009 | 19573611 | Yes |
| 3747 | 3250 | 1083.3 | 74.76 | 24.9 | Marginal structural models and causal inference in epidemiology. | J M Robins, M A Hernán, B Brumback | Epidemiology | 2000 | 10955408 | Yes |
| 3748 | 2166 | 1083.0 | 92.74 | 46.4 | Severe psoriasis--oral therapy with a new retinoid. | T Fredriksson, U Pettersson | Dermatologica | 1978 | 357213 | Yes |
| 3749 | 1083 | 1083.0 | 18.22 | 18.2 | Evolution and tinkering. | F Jacob | Science | 1977 | 860134 | Yes |
| 3750 | 2166 | 1083.0 | 86.06 | 43.0 | Hearing lips and seeing voices. | H McGurk, J MacDonald | Nature | 1976 | 1012311 | Yes |
| 3751 | 1083 | 1083.0 | 28.97 | 29.0 | Ion suppression in mass spectrometry. | Thomas M Annesley | Clin Chem | 2003 | 12816898 | No |
| 3752 | 1083 | 1083.0 | 10.88 | 10.9 | Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. | R M Berne | Am J Physiol | 1963 | 13971060 | Yes |
| 3753 | 1083 | 1083.0 | 28.6 | 28.6 | Optogenetics. | Karl Deisseroth | Nat Methods | 2011 | 21191368 | Yes |
| 3754 | 2166 | 1083.0 | 72.59 | 36.3 | Photoacoustic tomography: in vivo imaging from organelles to organs. | Lihong V Wang, Song Hu | Science | 2012 | 22442475 | No |
| 3755 | 2165 | 1082.5 | 46.41 | 23.2 | Modified reagents for determination of urea and ammonia. | A L Chaney, E P Marbach | Clin Chem | 1962 | 13878063 | Yes |
| 3756 | 1082 | 1082.0 | 35.55 | 35.5 | Perceptual load as a necessary condition for selective attention. | N Lavie | J Exp Psychol Hum Percept Perform | 1995 | 7790827 | Yes |
| 3757 | 1082 | 1082.0 | 18.3 | 18.3 | Molecular mechanisms of axon guidance. | Barry J Dickson | Science | 2002 | 12471249 | No |
| 3758 | 1082 | 1082.0 | 11.53 | 11.5 | The Permeability Of Capillaries In Various Organs As Determined By Use Of The 'Indicator Diffusion' Method. | C Crone | Acta Physiol Scand | 1963 | 14078649 | Yes |
| 3759 | 1082 | 1082.0 | 32.78 | 32.8 | Social cognition and the brain: a meta-analysis. | Frank Van Overwalle | Hum Brain Mapp | 2009 | 18381770 | Yes |
| 3760 | 2163 | 1081.5 | 47.01 | 23.5 | Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. | T Hunter, J Pines | Cell | 1994 | 7954824 | No |
| 3761 | 1081 | 1081.0 | 27.43 | 27.4 | Avidin. | N M Green | Adv Protein Chem | 1975 | 237414 | Yes |
| 3762 | 1081 | 1081.0 | 19.16 | 19.2 | Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities. | F Fonnum | Biochem J | 1969 | 4982085 | Yes |
| 3763 | 1081 | 1081.0 | 37.36 | 37.4 | The frailty syndrome: definition and natural history. | Qian-Li Xue | Clin Geriatr Med | 2011 | 21093718 | No |
| 3764 | 1081 | 1081.0 | 31.57 | 31.6 | Phosphoinositides: tiny lipids with giant impact on cell regulation. | Tamas Balla | Physiol Rev | 2013 | 23899561 | No |
| 3765 | 6484 | 1080.7 | 179.63 | 29.9 | Mild cognitive impairment: clinical characterization and outcome. | R C Petersen, G E Smith, S C Waring, R J Ivnik, E G Tangalos, E Kokmen | Arch Neurol | 1999 | 10190820 | Yes |
| 3766 | 5403 | 1080.6 | 195.47 | 39.1 | A new clinical scale for the staging of dementia. | C P Hughes, L Berg, W L Danziger, L A Coben, R L Martin | Br J Psychiatry | 1982 | 7104545 | Yes |
| 3767 | 1080 | 1080.0 | 40.95 | 41.0 | A new international staging system for lung cancer. | C F Mountain | Chest | 1986 | 3514171 | No |
| 3768 | 1080 | 1080.0 | 45.29 | 45.3 | Clinical experience with impedance audiometry. | J Jerger | Arch Otolaryngol | 1970 | 5455571 | Yes |
| 3769 | 2160 | 1080.0 | 44.94 | 22.5 | Mitogen-activated protein kinase pathways. | M J Robinson, M H Cobb | Curr Opin Cell Biol | 1997 | 9069255 | No |
| 3770 | 1080 | 1080.0 | 20.2 | 20.2 | Progress in human tumour immunology and immunotherapy. | S A Rosenberg | Nature | 2001 | 11357146 | No |
| 3771 | 1080 | 1080.0 | 29.13 | 29.1 | A perspective on judgment and choice: mapping bounded rationality. | Daniel Kahneman | Am Psychol | 2003 | 14584987 | No |
| 3772 | 4320 | 1080.0 | 104.08 | 26.0 | CHARMM-GUI: a web-based graphical user interface for CHARMM. | Sunhwan Jo, Taehoon Kim, Vidyashankara G Iyer, Wonpil Im | J Comput Chem | 2008 | 18351591 | No |
| 3773 | 1080 | 1080.0 | 31.37 | 31.4 | ERK1/2 MAP kinases: structure, function, and regulation. | Robert Roskoski | Pharmacol Res | 2012 | 22569528 | No |
| 3774 | 2159 | 1079.5 | 57.17 | 28.6 | The evolution of cooperation. | R Axelrod, W D Hamilton | Science | 1981 | 7466396 | Yes |
| 3775 | 1079 | 1079.0 | 27.23 | 27.2 | Selectins: interpreters of cell-specific carbohydrate information during inflammation. | L A Lasky | Science | 1992 | 1439808 | No |
| 3776 | 1079 | 1079.0 | 26.13 | 26.1 | Looking into the functional architecture of the brain with diffusion MRI. | Denis Le Bihan | Nat Rev Neurosci | 2003 | 12778119 | No |
| 3777 | 1079 | 1079.0 | 25.12 | 25.1 | Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures. | Frank Würthner | Chem Commun (Camb) | 2004 | 15263926 | Yes |
| 3778 | 1079 | 1079.0 | 30.74 | 30.7 | Depression in the elderly. | George S Alexopoulos | Lancet | 2005 | 15936426 | No |
| 3779 | 1079 | 1079.0 | 40.65 | 40.6 | Electrolytes and interphases in Li-ion batteries and beyond. | Kang Xu | Chem Rev | 2014 | 25351820 | Yes |
| 3780 | 2157 | 1078.5 | 43.23 | 21.6 | A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. | C S Hoffman, F Winston | Gene | 1987 | 3319781 | Yes |
| 3781 | 6470 | 1078.3 | 138.88 | 23.1 | Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. | D A Melton, P A Krieg, M R Rebagliati, T Maniatis, K Zinn, M R Green | Nucleic Acids Res | 1984 | 6091052 | Yes |
| 3782 | 1078 | 1078.0 | 54.33 | 54.3 | The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. | J A Koufman | Laryngoscope | 1991 | 1895864 | No |
| 3783 | 1078 | 1078.0 | 27.03 | 27.0 | Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. | M J Berridge | Biochem J | 1983 | 6309155 | Yes |
| 3784 | 1078 | 1078.0 | 18.73 | 18.7 | Regulatory T cells in autoimmmunity*. | E M Shevach | Annu Rev Immunol | 2000 | 10837065 | No |
| 3785 | 1078 | 1078.0 | 21.51 | 21.5 | The sequence manipulation suite: JavaScript programs for analyzing and formatting protein and DNA sequences. | P Stothard | Biotechniques | 2000 | 10868275 | Yes |
| 3786 | 1078 | 1078.0 | 30.28 | 30.3 | The mechanisms of alloxan- and streptozotocin-induced diabetes. | S Lenzen | Diabetologia | 2008 | 18087688 | No |
| 3787 | 1078 | 1078.0 | 35.04 | 35.0 | Dual-processing accounts of reasoning, judgment, and social cognition. | Jonathan St B T Evans | Annu Rev Psychol | 2008 | 18154502 | No |
| 3788 | 2155 | 1077.5 | 69.86 | 34.9 | Population growth makes waves in the distribution of pairwise genetic differences. | A R Rogers, H Harpending | Mol Biol Evol | 1992 | 1316531 | Yes |
| 3789 | 2155 | 1077.5 | 53.67 | 26.8 | The regulation and function of c-fos and other immediate early genes in the nervous system. | M Sheng, M E Greenberg | Neuron | 1990 | 1969743 | No |
| 3790 | 2155 | 1077.5 | 43.3 | 21.6 | In search of the 'missing self': MHC molecules and NK cell recognition. | H G Ljunggren, K Kärre | Immunol Today | 1990 | 2201309 | No |
| 3791 | 2155 | 1077.5 | 48.28 | 24.1 | Effect of pegylation on pharmaceuticals. | J Milton Harris, Robert B Chess | Nat Rev Drug Discov | 2003 | 12612647 | No |
| 3792 | 4309 | 1077.2 | 101.97 | 25.5 | The epidemiology of sepsis in the United States from 1979 through 2000. | Greg S Martin, David M Mannino, Stephanie Eaton, Marc Moss | N Engl J Med | 2003 | 12700374 | Yes |
| 3793 | 1077 | 1077.0 | 32.99 | 33.0 | Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. | P Stastny | N Engl J Med | 1978 | 147420 | Yes |
| 3794 | 1077 | 1077.0 | 30.65 | 30.6 | Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. | T Feizi | Nature | 1985 | 2579340 | Yes |
| 3795 | 1077 | 1077.0 | 28.9 | 28.9 | Statistical quality control and routine data processing for radioimmunoassays and immunoradiometric assays. | D Rodbard | Clin Chem | 1974 | 4370388 | No |
| 3796 | 1077 | 1077.0 | 29.99 | 30.0 | A teacher rating scale for use in drug studies with children. | C K Conners | Am J Psychiatry | 1969 | 4900822 | Yes |
| 3797 | 1077 | 1077.0 | 16.14 | 16.1 | The moulding of senescence by natural selection. | W D Hamilton | J Theor Biol | 1966 | 6015424 | Yes |
| 3798 | 1077 | 1077.0 | 37.51 | 37.5 | Coronary physiology. | E O Feigl | Physiol Rev | 1983 | 6296890 | No |
| 3799 | 1077 | 1077.0 | 23.08 | 23.1 | PHD: predicting one-dimensional protein structure by profile-based neural networks. | B Rost | Methods Enzymol | 1996 | 8743704 | Yes |
| 3800 | 1077 | 1077.0 | 26.43 | 26.4 | Biological effects of resveratrol. | L Frémont | Life Sci | 2000 | 10680575 | No |
| 3801 | 6458 | 1076.3 | 173.37 | 28.9 | Cancer statistics, 2007. | Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Taylor Murray, Jiaquan Xu, Michael J Thun | CA Cancer J Clin | 2007 | 17237035 | Yes |
| 3802 | 1076 | 1076.0 | 27.44 | 27.4 | Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. | J P Tam | Proc Natl Acad Sci U S A | 1988 | 3399498 | Yes |
| 3803 | 1076 | 1076.0 | 26.56 | 26.6 | Anti-inflammatory actions of glucocorticoids: molecular mechanisms. | P J Barnes | Clin Sci (Lond) | 1998 | 9854452 | No |
| 3804 | 1076 | 1076.0 | 35.88 | 35.9 | What Good Are Positive Emotions? | Barbara L Fredrickson | Rev Gen Psychol | 1998 | 21850154 | Yes |
| 3805 | 2151 | 1075.5 | 63.34 | 31.7 | Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. | J M Reul, E R de Kloet | Endocrinology | 1985 | 2998738 | Yes |
| 3806 | 2150 | 1075.0 | 37.66 | 18.8 | Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. | W Gu, R G Roeder | Cell | 1997 | 9288740 | Yes |
| 3807 | 1075 | 1075.0 | 38.79 | 38.8 | Relativistic electronic-structure calculations employing a two-component no-pair formalism with external-field projection operators. | B A Hess | Phys Rev A Gen Phys | 1986 | 9897114 | Yes |
| 3808 | 2150 | 1075.0 | 85.95 | 43.0 | Chronic catheterization of the spinal subarachnoid space. | T L Yaksh, T A Rudy | Physiol Behav | 1976 | 14677603 | Yes |
| 3809 | 1075 | 1075.0 | 32.19 | 32.2 | Periodontitis: a polymicrobial disruption of host homeostasis. | Richard P Darveau | Nat Rev Microbiol | 2010 | 20514045 | No |
| 3810 | 2150 | 1075.0 | 114.47 | 57.2 | New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. | Anushka Dongre, Robert A Weinberg | Nat Rev Mol Cell Biol | 2019 | 30459476 | No |
| 3811 | 4297 | 1074.2 | 110.88 | 27.7 | A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. | I Vermes, C Haanen, H Steffens-Nakken, C Reutelingsperger | J Immunol Methods | 1995 | 7622868 | Yes |
| 3812 | 1074 | 1074.0 | 0.0 | 0.0 | The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs. | M Vogt | J Physiol | 1954 | 13152692 | Yes |
| 3813 | 3221 | 1073.7 | 167.44 | 55.8 | Relatives of the impaired elderly: correlates of feelings of burden. | S H Zarit, K E Reever, J Bach-Peterson | Gerontologist | 1980 | 7203086 | Yes |
| 3814 | 1073 | 1073.0 | 42.24 | 42.2 | Functional connections between cells as revealed by dye-coupling with a highly fluorescent naphthalimide tracer. | W W Stewart | Cell | 1978 | 688392 | Yes |
| 3815 | 1073 | 1073.0 | 26.33 | 26.3 | The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. | David S Ludwig | JAMA | 2002 | 11988062 | No |
| 3816 | 1073 | 1073.0 | 27.03 | 27.0 | Targeting cancer metabolism: a therapeutic window opens. | Matthew G Vander Heiden | Nat Rev Drug Discov | 2011 | 21878982 | No |
| 3817 | 1073 | 1073.0 | 45.41 | 45.4 | Bisphenol A and human health: a review of the literature. | Johanna R Rochester | Reprod Toxicol | 2013 | 23994667 | No |
| 3818 | 1072 | 1072.0 | 31.24 | 31.2 | Why people use health services. | I M Rosenstock | Milbank Mem Fund Q | 1966 | 5967464 | Yes |
| 3819 | 1072 | 1072.0 | 30.7 | 30.7 | Muscarinic receptors--characterization, coupling and function. | M P Caulfield | Pharmacol Ther | 1993 | 7504306 | No |
| 3820 | 1072 | 1072.0 | 29.21 | 29.2 | Synchronization of cortical activity and its putative role in information processing and learning. | W Singer | Annu Rev Physiol | 1993 | 8466179 | No |
| 3821 | 1072 | 1072.0 | 33.28 | 33.3 | Food reward: brain substrates of wanting and liking. | K C Berridge | Neurosci Biobehav Rev | 1996 | 8622814 | No |
| 3822 | 2143 | 1071.5 | 39.35 | 19.7 | Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. | R Daniel Gietz, Robin A Woods | Methods Enzymol | 2002 | 12073338 | Yes |
| 3823 | 2143 | 1071.5 | 57.79 | 28.9 | Targeting hypoxia in cancer therapy. | William R Wilson, Michael P Hay | Nat Rev Cancer | 2011 | 21606941 | No |
| 3824 | 1071 | 1071.0 | 25.61 | 25.6 | Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. | Mark E Bouton | Biol Psychiatry | 2002 | 12437938 | No |
| 3825 | 1071 | 1071.0 | 29.84 | 29.8 | Transcranial magnetic stimulation: a primer. | Mark Hallett | Neuron | 2007 | 17640522 | No |
| 3826 | 1071 | 1071.0 | 30.95 | 30.9 | Serine, glycine and one-carbon units: cancer metabolism in full circle. | Jason W Locasale | Nat Rev Cancer | 2013 | 23822983 | No |
| 3827 | 2141 | 1070.5 | 63.06 | 31.5 | Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. | C N Hales, D J Barker | Diabetologia | 1992 | 1644236 | No |
| 3828 | 2141 | 1070.5 | 48.08 | 24.0 | Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. | Sharon R Browning, Brian L Browning | Am J Hum Genet | 2007 | 17924348 | Yes |
| 3829 | 2141 | 1070.5 | 53.62 | 26.8 | An improved general amino acid replacement matrix. | Si Quang Le, Olivier Gascuel | Mol Biol Evol | 2008 | 18367465 | Yes |
| 3830 | 2140 | 1070.0 | 83.5 | 41.8 | Glutathione reductase. | I Carlberg, B Mannervik | Methods Enzymol | 1985 | 3003504 | Yes |
| 3831 | 4280 | 1070.0 | 109.88 | 27.5 | Real time quantitative PCR. | C A Heid, J Stevens, K J Livak, P M Williams | Genome Res | 1996 | 8908518 | Yes |
| 3832 | 1070 | 1070.0 | 29.43 | 29.4 | Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. | John W Newcomer | CNS Drugs | 2005 | 15998156 | No |
| 3833 | 1070 | 1070.0 | 24.8 | 24.8 | Sjögren's syndrome. | Robert I Fox | Lancet | 2005 | 16039337 | No |
| 3834 | 2139 | 1069.5 | 69.31 | 34.7 | Polymyositis and dermatomyositis (second of two parts). | A Bohan, J B Peter | N Engl J Med | 1975 | 1089199 | No |
| 3835 | 2139 | 1069.5 | 105.55 | 52.8 | Optimism, coping, and health: assessment and implications of generalized outcome expectancies. | M F Scheier, C S Carver | Health Psychol | 1985 | 4029106 | Yes |
| 3836 | 2139 | 1069.5 | 62.1 | 31.1 | Accurate molecular van der Waals interactions from ground-state electron density and free-atom reference data. | Alexandre Tkatchenko, Matthias Scheffler | Phys Rev Lett | 2009 | 19257665 | Yes |
| 3837 | 2139 | 1069.5 | 63.92 | 32.0 | The memory function of sleep. | Susanne Diekelmann, Jan Born | Nat Rev Neurosci | 2010 | 20046194 | No |
| 3838 | 1069 | 1069.0 | 29.48 | 29.5 | Mitochondrial genetics: a paradigm for aging and degenerative diseases? | D C Wallace | Science | 1992 | 1533953 | Yes |
| 3839 | 1069 | 1069.0 | 30.88 | 30.9 | Microbial heavy-metal resistance. | D H Nies | Appl Microbiol Biotechnol | 1999 | 10422221 | No |
| 3840 | 6414 | 1069.0 | 162.71 | 27.1 | Ghrelin is a growth-hormone-releasing acylated peptide from stomach. | M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K Kangawa | Nature | 1999 | 10604470 | Yes |
| 3841 | 1069 | 1069.0 | 18.92 | 18.9 | Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. | W Kolch | Biochem J | 2000 | 11023813 | No |
| 3842 | 1069 | 1069.0 | 53.16 | 53.2 | Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress. | Helmut Sies | Redox Biol | 2017 | 28110218 | No |
| 3843 | 6412 | 1068.7 | 197.56 | 32.9 | Prodigal: prokaryotic gene recognition and translation initiation site identification. | Doug Hyatt, Gwo-Liang Chen, Philip F Locascio, Miriam L Land, Frank W Larimer, Loren J Hauser | BMC Bioinformatics | 2010 | 20211023 | Yes |
| 3844 | 1068 | 1068.0 | 23.36 | 23.4 | ECM and cell surface proteolysis: regulating cellular ecology. | Z Werb | Cell | 1997 | 9390552 | No |
| 3845 | 1068 | 1068.0 | 24.05 | 24.1 | The neurobiology of consolidations, or, how stable is the engram? | Yadin Dudai | Annu Rev Psychol | 2004 | 14744210 | No |
| 3846 | 5340 | 1068.0 | 199.92 | 40.0 | Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. | Jonathan D Power, Kelly A Barnes, Abraham Z Snyder, Bradley L Schlaggar, Steven E Petersen | Neuroimage | 2012 | 22019881 | Yes |
| 3847 | 4270 | 1067.5 | 106.51 | 26.6 | An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. | Joseph A Maldjian, Paul J Laurienti, Robert A Kraft, Jonathan H Burdette | Neuroimage | 2003 | 12880848 | Yes |
| 3848 | 1067 | 1067.0 | 43.71 | 43.7 | Movement, posture and equilibrium: interaction and coordination. | J Massion | Prog Neurobiol | 1992 | 1736324 | No |
| 3849 | 1067 | 1067.0 | 41.8 | 41.8 | Gait changes in older adults: predictors of falls or indicators of fear. | B E Maki | J Am Geriatr Soc | 1997 | 9063277 | Yes |
| 3850 | 2134 | 1067.0 | 45.4 | 22.7 | InterProScan--an integration platform for the signature-recognition methods in InterPro. | E M Zdobnov, R Apweiler | Bioinformatics | 2001 | 11590104 | Yes |
| 3851 | 1067 | 1067.0 | 0.0 | 0.0 | On the prediction of occurrence of particular verbal intrusions in immediate recall. | J Deese | J Exp Psychol | 1959 | 13664879 | Yes |
| 3852 | 1067 | 1067.0 | 0.0 | 0.0 | Neural basis of the spontaneous optokinetic response produced by visual inversion. | R W Sperry | J Comp Physiol Psychol | 1950 | 14794830 | Yes |
| 3853 | 1067 | 1067.0 | 21.19 | 21.2 | Automated NMR structure calculation with CYANA. | Peter Güntert | Methods Mol Biol | 2004 | 15318003 | Yes |
| 3854 | 6400 | 1066.7 | 238.92 | 39.8 | StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. | Mihaela Pertea, Geo M Pertea, Corina M Antonescu, Tsung-Cheng Chang, Joshua T Mendell, Steven L Salzberg | Nat Biotechnol | 2015 | 25690850 | Yes |
| 3855 | 4266 | 1066.5 | 217.93 | 54.5 | National Institute of Mental Health Diagnostic Interview Schedule. Its history, characteristics, and validity. | L N Robins, J E Helzer, J Croughan, K S Ratcliff | Arch Gen Psychiatry | 1981 | 6260053 | Yes |
| 3856 | 2132 | 1066.0 | 37.94 | 19.0 | Calcium-dependent bacteriophage DNA infection. | M Mandel, A Higa | J Mol Biol | 1970 | 4922220 | Yes |
| 3857 | 1066 | 1066.0 | 32.83 | 32.8 | Prevention of drug access to bacterial targets: permeability barriers and active efflux. | H Nikaido | Science | 1994 | 8153625 | No |
| 3858 | 1066 | 1066.0 | 42.76 | 42.8 | Epidemiology and risk factors for IBD. | Ashwin N Ananthakrishnan | Nat Rev Gastroenterol Hepatol | 2015 | 25732745 | No |
| 3859 | 1066 | 1066.0 | 33.8 | 33.8 | Isolation By Distance In Equilibrium And Non-Equilibrium Populations. | Montgomery Slatkin | Evolution | 1993 | 28568097 | Yes |
| 3860 | 2131 | 1065.5 | 72.98 | 36.5 | The pathogenesis of atherosclerosis (first of two parts). | R Ross, J A Glomset | N Engl J Med | 1976 | 819830 | No |
| 3861 | 1065 | 1065.0 | 26.96 | 27.0 | Axonal growth-associated proteins. | J H Skene | Annu Rev Neurosci | 1989 | 2648946 | No |
| 3862 | 2130 | 1065.0 | 79.83 | 39.9 | A psychomotor stimulant theory of addiction. | R A Wise, M A Bozarth | Psychol Rev | 1987 | 3317472 | No |
| 3863 | 1065 | 1065.0 | 25.61 | 25.6 | Metagenomics: application of genomics to uncultured microorganisms. | Jo Handelsman | Microbiol Mol Biol Rev | 2004 | 15590779 | No |
| 3864 | 1065 | 1065.0 | 32.22 | 32.2 | Pectin structure and biosynthesis. | Debra Mohnen | Curr Opin Plant Biol | 2008 | 18486536 | No |
| 3865 | 7454 | 1064.9 | 129.58 | 18.5 | The human genome browser at UCSC. | W James Kent, Charles W Sugnet, Terrence S Furey, Krishna M Roskin, Tom H Pringle, Alan M Zahler, David Haussler | Genome Res | 2002 | 12045153 | Yes |
| 3866 | 3193 | 1064.3 | 80.91 | 27.0 | Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions. | M Piotto, V Saudek, V Sklenár | J Biomol NMR | 1992 | 1490109 | Yes |
| 3867 | 2128 | 1064.0 | 59.87 | 29.9 | Binding of soluble form of fibroblast surface protein, fibronectin, to collagen. | E Engvall, E Ruoslahti | Int J Cancer | 1977 | 903179 | Yes |
| 3868 | 1064 | 1064.0 | 39.58 | 39.6 | Infection by verocytotoxin-producing Escherichia coli. | M A Karmali | Clin Microbiol Rev | 1989 | 2644022 | No |
| 3869 | 1064 | 1064.0 | 30.04 | 30.0 | Epidemiology of cancer of the colon and rectum. | D P Burkitt | Cancer | 1971 | 5165022 | Yes |
| 3870 | 1064 | 1064.0 | 28.47 | 28.5 | Inhibition of return. | R M Klein | Trends Cogn Sci | 2000 | 10740278 | Yes |
| 3871 | 1064 | 1064.0 | 21.99 | 22.0 | Oxidant signals and oxidative stress. | Toren Finkel | Curr Opin Cell Biol | 2003 | 12648682 | No |
| 3872 | 1064 | 1064.0 | 33.82 | 33.8 | Determining association constants from titration experiments in supramolecular chemistry. | Pall Thordarson | Chem Soc Rev | 2011 | 21125111 | Yes |
| 3873 | 1064 | 1064.0 | 36.63 | 36.6 | Stochastic thermodynamics, fluctuation theorems and molecular machines. | Udo Seifert | Rep Prog Phys | 2012 | 23168354 | No |
| 3874 | 1064 | 1064.0 | 51.2 | 51.2 | Using Bayes to get the most out of non-significant results. | Zoltan Dienes | Front Psychol | 2014 | 25120503 | Yes |
| 3875 | 2127 | 1063.5 | 62.97 | 31.5 | Extended-spectrum beta-lactamases: a clinical update. | David L Paterson, Robert A Bonomo | Clin Microbiol Rev | 2005 | 16223952 | No |
| 3876 | 3190 | 1063.3 | 69.26 | 23.1 | Population structure and eigenanalysis. | Nick Patterson, Alkes L Price, David Reich | PLoS Genet | 2006 | 17194218 | Yes |
| 3877 | 1063 | 1063.0 | 26.34 | 26.3 | Skeletal complications of malignancy. | R E Coleman | Cancer | 1997 | 9362426 | No |
| 3878 | 1063 | 1063.0 | 24.68 | 24.7 | Biochemistry and genetics of von Willebrand factor. | J E Sadler | Annu Rev Biochem | 1998 | 9759493 | No |
| 3879 | 1063 | 1063.0 | 22.66 | 22.7 | Ligand-targeted therapeutics in anticancer therapy. | Theresa M Allen | Nat Rev Cancer | 2002 | 12360278 | No |
| 3880 | 2125 | 1062.5 | 48.19 | 24.1 | The significance of digital gene expression profiles. | S Audic, J M Claverie | Genome Res | 1997 | 9331369 | Yes |
| 3881 | 3187 | 1062.3 | 149.03 | 49.7 | Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. | M Jondal, G Holm, H Wigzell | J Exp Med | 1972 | 4114496 | Yes |
| 3882 | 6373 | 1062.2 | 147.91 | 24.7 | Enzymatic assembly of DNA molecules up to several hundred kilobases. | Daniel G Gibson, Lei Young, Ray-Yuan Chuang, J Craig Venter, Clyde A Hutchison, Hamilton O Smith | Nat Methods | 2009 | 19363495 | Yes |
| 3883 | 1062 | 1062.0 | 77.17 | 77.2 | Fibula free flap: a new method of mandible reconstruction. | D A Hidalgo | Plast Reconstr Surg | 1989 | 2734406 | Yes |
| 3884 | 1062 | 1062.0 | 24.73 | 24.7 | Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. | S H Kaufmann | Cancer Res | 1989 | 2790800 | Yes |
| 3885 | 1062 | 1062.0 | 28.88 | 28.9 | Microtubule formation in vitro in solutions containing low calcium concentrations. | R C Weisenberg | Science | 1972 | 4626639 | Yes |
| 3886 | 1062 | 1062.0 | 30.49 | 30.5 | Distracted and confused?: selective attention under load. | Nilli Lavie | Trends Cogn Sci | 2005 | 15668100 | No |
| 3887 | 1062 | 1062.0 | 0.0 | 0.0 | A Serological Differentiation Of Human And Other Groups Of Hemolytic Streptococci. | R C Lancefield | J Exp Med | 1933 | 19870148 | Yes |
| 3888 | 3185 | 1061.7 | 115.16 | 38.4 | Stimuli-responsive nanocarriers for drug delivery. | Simona Mura, Julien Nicolas, Patrick Couvreur | Nat Mater | 2013 | 24150417 | No |
| 3889 | 2123 | 1061.5 | 0.0 | 0.0 | A microcolorimetric method for the determination of inorganic phosphorus. | H H Taussky, E Shorr | J Biol Chem | 1953 | 13061491 | Yes |
| 3890 | 1061 | 1061.0 | 29.18 | 29.2 | Junctional intercellular communication: the cell-to-cell membrane channel. | W R Loewenstein | Physiol Rev | 1981 | 6270711 | No |
| 3891 | 1061 | 1061.0 | 0.0 | 0.0 | On the Absorption of Fluids from the Connective Tissue Spaces. | E H Starling | J Physiol | 1896 | 16992325 | Yes |
| 3892 | 1061 | 1061.0 | 31.96 | 32.0 | Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. | Bruce S McEwen | Eur J Pharmacol | 2008 | 18282566 | No |
| 3893 | 1061 | 1061.0 | 53.38 | 53.4 | Statistical notes for clinical researchers: assessing normal distribution (2) using skewness and kurtosis. | Hae-Young Kim | Restor Dent Endod | 2013 | 23495371 | Yes |
| 3894 | 1061 | 1061.0 | 67.77 | 67.8 | Critical Analysis of Strategies for Determining Rigor in Qualitative Inquiry. | Janice M Morse | Qual Health Res | 2015 | 26184336 | Yes |
| 3895 | 4243 | 1060.8 | 81.42 | 20.4 | DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. | M Okano, D W Bell, D A Haber, E Li | Cell | 1999 | 10555141 | Yes |
| 3896 | 3182 | 1060.7 | 76.09 | 25.4 | Nitric oxide and macrophage function. | J MacMicking, Q W Xie, C Nathan | Annu Rev Immunol | 1997 | 9143691 | No |
| 3897 | 2121 | 1060.5 | 40.02 | 20.0 | Wnt signaling: a common theme in animal development. | K M Cadigan, R Nusse | Genes Dev | 1997 | 9407023 | No |
| 3898 | 6362 | 1060.3 | 271.44 | 45.2 | GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. | Zefang Tang, Chenwei Li, Boxi Kang, Ge Gao, Cheng Li, Zemin Zhang | Nucleic Acids Res | 2017 | 28407145 | Yes |
| 3899 | 1060 | 1060.0 | 30.32 | 30.3 | Pathogenetic mechanisms of septic shock. | J E Parrillo | N Engl J Med | 1993 | 8479467 | No |
| 3900 | 1060 | 1060.0 | 23.14 | 23.1 | Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. | Ferric C Fang | Nat Rev Microbiol | 2004 | 15378046 | No |
| 3901 | 2120 | 1060.0 | 52.87 | 26.4 | The regulation of IL-10 production by immune cells. | Margarida Saraiva, Anne O'Garra | Nat Rev Immunol | 2010 | 20154735 | No |
| 3902 | 2120 | 1060.0 | 54.99 | 27.5 | Sterile inflammation: sensing and reacting to damage. | Grace Y Chen, Gabriel Nuñez | Nat Rev Immunol | 2010 | 21088683 | No |
| 3903 | 2119 | 1059.5 | 82.32 | 41.2 | Comparative aspects of the brain growth spurt. | J Dobbing, J Sands | Early Hum Dev | 1979 | 118862 | Yes |
| 3904 | 2119 | 1059.5 | 45.89 | 22.9 | Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. | P J Roberts, C J Der | Oncogene | 2007 | 17496923 | No |
| 3905 | 2119 | 1059.5 | 44.08 | 22.0 | Fcgamma receptors as regulators of immune responses. | Falk Nimmerjahn, Jeffrey V Ravetch | Nat Rev Immunol | 2008 | 18064051 | No |
| 3906 | 3178 | 1059.3 | 106.64 | 35.5 | A new rating scale for Alzheimer's disease. | W G Rosen, R C Mohs, K L Davis | Am J Psychiatry | 1984 | 6496779 | Yes |
| 3907 | 1059 | 1059.0 | 36.17 | 36.2 | A theory of visual attention. | C Bundesen | Psychol Rev | 1990 | 2247540 | Yes |
| 3908 | 1059 | 1059.0 | 36.71 | 36.7 | A colorimetric method for estimating serum triglycerides. | M J Fletcher | Clin Chim Acta | 1968 | 5696963 | Yes |
| 3909 | 1059 | 1059.0 | 30.07 | 30.1 | Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine. | E M Tan | Adv Immunol | 1982 | 6182766 | No |
| 3910 | 1059 | 1059.0 | 23.24 | 23.2 | Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. | J Denis McGarry | Diabetes | 2002 | 11756317 | No |
| 3911 | 1059 | 1059.0 | 29.65 | 29.6 | Micellar nanocarriers: pharmaceutical perspectives. | V P Torchilin | Pharm Res | 2007 | 17109211 | No |
| 3912 | 2117 | 1058.5 | 0.0 | 0.0 | Use of glucose oxidase, peroxidase, and O-dianisidine in determination of blood and urinary glucose. | A S Huggett, D A Nixon | Lancet | 1957 | 13464070 | Yes |
| 3913 | 2117 | 1058.5 | 63.97 | 32.0 | Regulation of type I interferon responses. | Lionel B Ivashkiv, Laura T Donlin | Nat Rev Immunol | 2014 | 24362405 | No |
| 3914 | 1058 | 1058.0 | 29.76 | 29.8 | Hepatitis B virus. The major etiology of hepatocellular carcinoma. | R P Beasley | Cancer | 1988 | 2834034 | No |
| 3915 | 1058 | 1058.0 | 13.85 | 13.8 | Relative and absolute strength of response as a function of frequency of reinforcement. | R J Herrnstein | J Exp Anal Behav | 1961 | 13713775 | Yes |
| 3916 | 1058 | 1058.0 | 28.94 | 28.9 | Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life. | Barry Halliwell | Plant Physiol | 2006 | 16760481 | Yes |
| 3917 | 1058 | 1058.0 | 31.74 | 31.7 | G(ST) and its relatives do not measure differentiation. | Lou Jost | Mol Ecol | 2008 | 19238703 | Yes |
| 3918 | 2115 | 1057.5 | 61.73 | 30.9 | The biochemistry of P-glycoprotein-mediated multidrug resistance. | J A Endicott, V Ling | Annu Rev Biochem | 1989 | 2570548 | No |
| 3919 | 2115 | 1057.5 | 0.0 | 0.0 | Histochemistry of hepatic phosphatases of a physiologic pH; with special reference to the demonstration of bile canaliculi. | M Wachstein, E Meisel | Am J Clin Pathol | 1957 | 13410831 | Yes |
| 3920 | 1057 | 1057.0 | 40.01 | 40.0 | The ovariectomized rat model of postmenopausal bone loss. | D N Kalu | Bone Miner | 1991 | 1773131 | No |
| 3921 | 2114 | 1057.0 | 86.9 | 43.5 | A real-time QRS detection algorithm. | J Pan, W J Tompkins | IEEE Trans Biomed Eng | 1985 | 3997178 | Yes |
| 3922 | 1057 | 1057.0 | 25.15 | 25.1 | The tragedy of the commons. The population problem has no technical solution; it requires a fundamental extension in morality. | G Hardin | Science | 1968 | 5699198 | Yes |
| 3923 | 1057 | 1057.0 | 43.28 | 43.3 | Toward terminological, conceptual, and statistical clarity in the study of mediators and moderators: examples from the child-clinical and pediatric psychology literatures. | G N Holmbeck | J Consult Clin Psychol | 1997 | 9256561 | Yes |
| 3924 | 1057 | 1057.0 | 29.37 | 29.4 | Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes. | R Bonnet | Antimicrob Agents Chemother | 2004 | 14693512 | No |
| 3925 | 1057 | 1057.0 | 31.13 | 31.1 | Regulation of immune responses by prostaglandin E2. | Pawel Kalinski | J Immunol | 2012 | 22187483 | No |
| 3926 | 1057 | 1057.0 | 32.14 | 32.1 | Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. | Rakesh K Jain | Cancer Cell | 2014 | 25517747 | No |
| 3927 | 4227 | 1056.8 | 114.14 | 28.5 | Gene ontology analysis for RNA-seq: accounting for selection bias. | Matthew D Young, Matthew J Wakefield, Gordon K Smyth, Alicia Oshlack | Genome Biol | 2010 | 20132535 | Yes |
| 3928 | 2113 | 1056.5 | 80.94 | 40.5 | Analysis of probability as an aid in the clinical diagnosis of coronary-artery disease. | G A Diamond, J S Forrester | N Engl J Med | 1979 | 440357 | Yes |
| 3929 | 2113 | 1056.5 | 58.35 | 29.2 | The diversity and biogeography of soil bacterial communities. | Noah Fierer, Robert B Jackson | Proc Natl Acad Sci U S A | 2006 | 16407148 | Yes |
| 3930 | 1056 | 1056.0 | 25.59 | 25.6 | The granulocyte-macrophage colony-stimulating factors. | D Metcalf | Science | 1985 | 2990035 | No |
| 3931 | 2112 | 1056.0 | 54.24 | 27.1 | Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. | M S Brown, J L Goldstein | Annu Rev Biochem | 1983 | 6311077 | No |
| 3932 | 3168 | 1056.0 | 66.46 | 22.2 | TGF-beta signalling from cell membrane to nucleus through SMAD proteins. | C H Heldin, K Miyazono, P ten Dijke | Nature | 1997 | 9393997 | No |
| 3933 | 1056 | 1056.0 | 33.72 | 33.7 | Staphylococcus epidermidis--the 'accidental' pathogen. | Michael Otto | Nat Rev Microbiol | 2009 | 19609257 | No |
| 3934 | 1055 | 1055.0 | 23.92 | 23.9 | The inducible transcription activator NF-kappa B: regulation by distinct protein subunits. | P A Baeuerle | Biochim Biophys Acta | 1991 | 2018779 | No |
| 3935 | 4220 | 1055.0 | 144.2 | 36.0 | Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. | S Pellow, P Chopin, S E File, M Briley | J Neurosci Methods | 1985 | 2864480 | Yes |
| 3936 | 2110 | 1055.0 | 44.99 | 22.5 | The immunoglobulin superfamily--domains for cell surface recognition. | A F Williams, A N Barclay | Annu Rev Immunol | 1988 | 3289571 | No |
| 3937 | 1055 | 1055.0 | 25.42 | 25.4 | The ultrastructural basis of capillary permeability studied with peroxidase as a tracer. | M J Karnovsky | J Cell Biol | 1967 | 6061717 | Yes |
| 3938 | 2110 | 1055.0 | 54.16 | 27.1 | Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. | Donald E Owens, Nicholas A Peppas | Int J Pharm | 2006 | 16303268 | No |
| 3939 | 1055 | 1055.0 | 35.56 | 35.6 | Drug transport across the blood-brain barrier. | William M Pardridge | J Cereb Blood Flow Metab | 2012 | 22929442 | No |
| 3940 | 1055 | 1055.0 | 42.4 | 42.4 | The non-canonical NF-κB pathway in immunity and inflammation. | Shao-Cong Sun | Nat Rev Immunol | 2017 | 28580957 | No |
| 3941 | 2109 | 1054.5 | 32.76 | 16.4 | The growth of mouse bone marrow cells in vitro. | T R Bradley, D Metcalf | Aust J Exp Biol Med Sci | 1966 | 4164182 | Yes |
| 3942 | 1054 | 1054.0 | 21.54 | 21.5 | The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells. | D Metcalf | Nature | 1989 | 2469962 | No |
| 3943 | 3162 | 1054.0 | 130.6 | 43.5 | A new method for detecting anaerobic threshold by gas exchange. | W L Beaver, K Wasserman, B J Whipp | J Appl Physiol (1985) | 1986 | 3087938 | Yes |
| 3944 | 1054 | 1054.0 | 29.72 | 29.7 | Determination of total protein. | G L Peterson | Methods Enzymol | 1983 | 6855607 | Yes |
| 3945 | 1054 | 1054.0 | 21.7 | 21.7 | The muscular dystrophies. | Alan E H Emery | Lancet | 2002 | 11879882 | No |
| 3946 | 1054 | 1054.0 | 26.54 | 26.5 | The potential environmental impact of engineered nanomaterials. | Vicki L Colvin | Nat Biotechnol | 2003 | 14520401 | Yes |
| 3947 | 1054 | 1054.0 | 26.25 | 26.2 | Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis. | Peter Fransson | Hum Brain Mapp | 2005 | 15852468 | Yes |
| 3948 | 1054 | 1054.0 | 32.54 | 32.5 | Chronic stress, drug use, and vulnerability to addiction. | Rajita Sinha | Ann N Y Acad Sci | 2008 | 18991954 | No |
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