Unicorn Papers

Top ‱ cited papers from PUBMED

Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authors
Currently, the list contains 3920 papers with ECcit ≥ 1052.0
‱ - permyriad, , literally meaning "for (every) myriad (ten thousand)"

Volume 49, September 2024

No. Citations ECcit RCR ECRCR Title Authors Journal Year PMID Article(?)
1224570224570.04918.174918.2Cleavage of structural proteins during the assembly of the head of bacteriophage T4. U K LaemmliNature19705432063Yes
2173039173039.07117.467117.5A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. M M BradfordAnal Biochem1976942051Yes
328584671461.50.00.0Protein measurement with the Folin phenol reagent. O H Lowry, N J Rosebrough, A L Farr, R J RandallJ Biol Chem195114907713Yes
412296561482.53049.81524.9Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. K J Livak, T D SchmittgenMethods200111846609Yes
54526245262.01392.641392.6A short history of SHELX. George M SheldrickActa Crystallogr A200818156677Yes
63687736877.01188.21188.2Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. T MosmannJ Immunol Methods19836606682Yes
76439732198.51932.53966.3Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. P Chomczynski, N SacchiAnal Biochem19872440339Yes
83023230232.0822.98823.0Detection of specific sequences among DNA fragments separated by gel electrophoresis. E M SouthernJ Mol Biol19751195397Yes
92800128001.0858.84858.8The assessment and analysis of handedness: the Edinburgh inventory. R C OldfieldNeuropsychologia19715146491Yes
102782227822.0612.43612.4MicroRNAs: genomics, biogenesis, mechanism, and function. David P BartelCell200414744438No
112700427004.0637.58637.6MUSCLE: multiple sequence alignment with high accuracy and high throughput. Robert C EdgarNucleic Acids Res200415034147Yes
122603226032.0674.73674.7A rating scale for depression. M HamiltonJ Neurol Neurosurg Psychiatry196014399272Yes
132478624786.0567.85567.9A new mathematical model for relative quantification in real-time RT-PCR. M W PfafflNucleic Acids Res200111328886Yes
142441924419.0759.87759.9Confidence Limits On Phylogenies: An Approach Using The Bootstrap. Joseph FelsensteinEvolution198528561359Yes
156638322127.72489.03829.7"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. M F Folstein, S E Folstein, P R McHughJ Psychiatr Res19751202204Yes
166597621992.01651.53550.5DNA sequencing with chain-terminating inhibitors. F Sanger, S Nicklen, A R CoulsonProc Natl Acad Sci U S A1977271968Yes
174278321391.51329.35664.7Hallmarks of cancer: the next generation. Douglas Hanahan, Robert A WeinbergCell201121376230No
182027920279.0204.98205.0The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. E S ReynoldsJ Cell Biol196313986422Yes
194019620098.01241.7620.9The neighbor-joining method: a new method for reconstructing phylogenetic trees. N Saitou, M NeiMol Biol Evol19873447015Yes
202009020090.0688.88688.9Density-functional exchange-energy approximation with correct asymptotic behavior. A D BeckePhys Rev A Gen Phys19889900728Yes
211960019600.00.00.0Tissue sulfhydryl groups. G L EllmanArch Biochem Biophys195913650640Yes
221830118301.0510.56510.6Projector augmented-wave method. P E BlöchlPhys Rev B Condens Matter19949976227Yes
233642118210.51720.89860.4Statistical methods for assessing agreement between two methods of clinical measurement. J M Bland, D G AltmanLancet19862868172Yes
243594717973.51501.69750.8The measurement of observer agreement for categorical data. J R Landis, G G KochBiometrics1977843571Yes
255349117830.31985.42661.8Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. H Towbin, T Staehelin, J GordonProc Natl Acad Sci U S A1979388439Yes
261726217262.0634.57634.6A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. M KimuraJ Mol Evol19807463489Yes
271709917099.0724.52724.5RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Alexandros StamatakisBioinformatics201424451623Yes
281696016960.0425.6425.6Atherosclerosis--an inflammatory disease. R RossN Engl J Med19999887164No
291675616756.0687.73687.7Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. B J DavisAnn N Y Acad Sci196414240539Yes
301639616396.0673.87673.9A power primer. J CohenPsychol Bull199219565683Yes
313241816209.00.00.0A rapid method of total lipid extraction and purification. E G Bligh, W J DyerCan J Biochem Physiol195913671378Yes
321620316203.0449.18449.2High resolution two-dimensional electrophoresis of proteins. P H O'FarrellJ Biol Chem1975236308Yes
331592415924.00.00.0A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. K BurtonBiochem J195613293190Yes
343110915554.5986.66493.3Fast gapped-read alignment with Bowtie 2. Ben Langmead, Steven L SalzbergNat Methods201222388286Yes
354621915406.31370.76456.9Generalized Gradient Approximation Made Simple. J P Perdew, K Burke, M ErnzerhofPhys Rev Lett199610062328Yes
361539715397.0386.24386.2MicroRNAs: target recognition and regulatory functions. David P BartelCell200919167326No
373025915129.51210.73605.4The hospital anxiety and depression scale. A S Zigmond, R P SnaithActa Psychiatr Scand19836880820Yes
384538615128.71296.34432.1CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. J D Thompson, D G Higgins, T J GibsonNucleic Acids Res19947984417Yes
394525815086.01676.08558.7Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Michael I Love, Wolfgang Huber, Simon AndersGenome Biol201425516281Yes
403017115085.5762.75381.4Fast and accurate short read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics200919451168Yes
412976314881.51115.55557.8Meta-analysis in clinical trials. R DerSimonian, N LairdControl Clin Trials19863802833Yes
421444014440.0562.37562.4Catalase in vitro. H AebiMethods Enzymol19846727660Yes
434187813959.30.00.0A simple method for the isolation and purification of total lipides from animal tissues. J Folch, M Lees, G H Sloane StanleyJ Biol Chem195713428781Yes
441331213312.0681.23681.2Crystal structure refinement with SHELXL. George M SheldrickActa Crystallogr C Struct Chem201525567568Yes
456338012676.01817.26363.5Basic local alignment search tool. S F Altschul, W Gish, W Miller, E W Myers, D J LipmanJ Mol Biol19902231712Yes
461262112621.00.00.0Phosphorus assay in column chromatography. G R BartlettJ Biol Chem195913641241Yes
472509612548.0517.71258.9Coot: model-building tools for molecular graphics. Paul Emsley, Kevin CowtanActa Crystallogr D Biol Crystallogr200415572765Yes
481247312473.0399.82399.8Search and clustering orders of magnitude faster than BLAST. Robert C EdgarBioinformatics201020709691Yes
492486812434.01018.82509.4The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. J E Ware, C D SherbourneMed Care19921593914Yes
502481012405.0680.85340.4Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. G Kresse, J FurthmüllerPhys Rev B Condens Matter19969984901Yes
511232612326.0314.74314.7Xds. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124692Yes
523603612012.01271.46423.8Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. C Lee, W Yang, R G ParrPhys Rev B Condens Matter19889944570Yes
531199511995.0136.92136.9The genetics of Caenorhabditis elegans. S BrennerGenetics19744366476Yes
542390211951.0521.28260.6Processing of X-ray diffraction data collected in oscillation mode. Z Otwinowski, W MinorMethods Enzymol199727754618Yes
551194711947.0361.46361.5The Psychophysics Toolbox. D H BrainardSpat Vis19979176952Yes
561193111931.0554.04554.0Self-efficacy: toward a unifying theory of behavioral change. A BanduraPsychol Rev1977847061Yes
572376011880.0642.21321.1Quantifying heterogeneity in a meta-analysis. Julian P T Higgins, Simon G ThompsonStat Med200212111919Yes
581175911759.0386.61386.6Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). J F KurtzkeNeurology19836685237Yes
593375111250.31315.82438.6Trimmomatic: a flexible trimmer for Illumina sequence data. Anthony M Bolger, Marc Lohse, Bjoern UsadelBioinformatics201424695404Yes
601097410974.0381.3381.3Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Andreas StangEur J Epidemiol201020652370Yes
611096610966.0418.31418.3A new method for measuring daytime sleepiness: the Epworth sleepiness scale. M W JohnsSleep19911798888Yes
621096110961.0438.99439.0Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Y KandaBone Marrow Transplant201323208313Yes
632156210781.0557.92279.0A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. A P Feinberg, B VogelsteinAnal Biochem19836312838Yes
642134210671.0816.19408.1MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Kazutaka Katoh, Daron M StandleyMol Biol Evol201323329690Yes
651053910539.0365.91365.9Structure validation in chemical crystallography. Anthony L SpekActa Crystallogr D Biol Crystallogr200919171970Yes
663158310527.7821.29273.8VMD: visual molecular dynamics. W Humphrey, A Dalke, K SchultenJ Mol Graph19968744570Yes
672103310516.5460.8230.4[20] Processing of X-ray diffraction data collected in oscillation mode. Zbyszek Otwinowski, Wladek MinorMethods Enzymol199727799103Yes
683127710425.71052.69350.9NIH Image to ImageJ: 25 years of image analysis. Caroline A Schneider, Wayne S Rasband, Kevin W EliceiriNat Methods201222930834No
692078210391.0890.65445.3The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. R M Baron, D A KennyJ Pers Soc Psychol19863806354Yes
704119910299.81176.65294.2Measuring inconsistency in meta-analyses. Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G AltmanBMJ200312958120No
714118110295.21588.64397.2Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanPLoS Med200919621072No
721029110291.0201.98202.0Improvements in epoxy resin embedding methods. J H LuftJ Biophys Biochem Cytol196113764136Yes
732052510262.5441.53220.8KEGG: kyoto encyclopedia of genes and genomes. M Kanehisa, S GotoNucleic Acids Res200010592173Yes
7499529952.00.00.0On the origin of cancer cells. O WarburgScience195613298683Yes
75197969898.0372.65186.3The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. K Weber, M OsbornJ Biol Chem19695806584Yes
7696639663.0271.88271.9Evolutionary trees from DNA sequences: a maximum likelihood approach. J FelsensteinJ Mol Evol19817288891Yes
7796249624.0434.85434.9Prokka: rapid prokaryotic genome annotation. Torsten SeemannBioinformatics201424642063Yes
7895689568.0410.87410.9Psychophysical bases of perceived exertion. G A BorgMed Sci Sports Exerc19827154893Yes
7995559555.0253.48253.5Semiempirical GGA-type density functional constructed with a long-range dispersion correction. Stefan GrimmeJ Comput Chem200616955487Yes
8095479547.0198.5198.5Mfold web server for nucleic acid folding and hybridization prediction. Michael ZukerNucleic Acids Res200312824337Yes
8194919491.0318.72318.7Banting lecture 1988. Role of insulin resistance in human disease. G M ReavenDiabetes19883056758No
82189809490.0490.97245.5A simple method for displaying the hydropathic character of a protein. J Kyte, R F DoolittleJ Mol Biol19827108955Yes
8393809380.0248.18248.2Studies on transformation of Escherichia coli with plasmids. D HanahanJ Mol Biol19836345791Yes
8493239323.0268.73268.7Vitamin D deficiency. Michael F HolickN Engl J Med200717634462No
8593219321.0272.34272.3The blockade of immune checkpoints in cancer immunotherapy. Drew M PardollNat Rev Cancer201222437870No
8692979297.0240.61240.6RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. Alexandros StamatakisBioinformatics200616928733Yes
8792569256.0263.23263.2Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. P S ThomasProc Natl Acad Sci U S A19806159641Yes
88367079176.81345.5336.4A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. M E Charlson, P Pompei, K L Ales, C R MacKenzieJ Chronic Dis19873558716Yes
8991709170.0259.38259.4The pathogenesis of atherosclerosis: a perspective for the 1990s. R RossNature19938479518No
90182319115.5381.78190.9The hallmarks of cancer. D Hanahan, R A WeinbergCell200010647931No
9190359035.0233.17233.2Integrins: versatility, modulation, and signaling in cell adhesion. R O HynesCell19921555235No
92266278875.7681.57227.2Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Da Wei Huang, Brad T Sherman, Richard A LempickiNat Protoc200919131956Yes
93175948797.0462.44231.2Analyzing real-time PCR data by the comparative C(T) method. Thomas D Schmittgen, Kenneth J LivakNat Protoc200818546601Yes
94351698792.21136.63284.2Bias in meta-analysis detected by a simple, graphical test. M Egger, G Davey Smith, M Schneider, C MinderBMJ19979310563Yes
9587818781.0177.39177.4Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Gordon K SmythStat Appl Genet Mol Biol200416646809Yes
9687578757.0211.45211.4PAML 4: phylogenetic analysis by maximum likelihood. Ziheng YangMol Biol Evol200717483113Yes
97522558709.23438.59573.1Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin JemalCA Cancer J Clin201830207593Yes
9887048704.0226.26226.3Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. M C HochbergArthritis Rheum19979324032Yes
9986768676.00.00.0Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. D I ArnonPlant Physiol194916654194Yes
100172818640.5379.17189.6Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Kazutoshi Takahashi, Shinya YamanakaCell200616904174Yes
10185368536.0180.91180.9The functions of animal microRNAs. Victor AmbrosNature200415372042No
10284558455.0221.27221.3Canonical dynamics: Equilibrium phase-space distributions. W G HooverPhys Rev A Gen Phys19859895674Yes
10383448344.0353.26353.3UPARSE: highly accurate OTU sequences from microbial amplicon reads. Robert C EdgarNat Methods201323955772Yes
104249378312.3662.51220.8edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Mark D Robinson, Davis J McCarthy, Gordon K SmythBioinformatics201019910308Yes
10582488248.00.00.0The assessment of anxiety states by rating. M HamiltonBr J Med Psychol195913638508Yes
10682488248.0215.71215.7Apoptosis: a review of programmed cell death. Susan ElmoreToxicol Pathol200717562483No
107246778225.71372.49457.5MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Sudhir Kumar, Glen Stecher, Koichiro TamuraMol Biol Evol201627004904Yes
10882248224.0410.11410.1SHELXT - integrated space-group and crystal-structure determination. George M SheldrickActa Crystallogr A Found Adv201525537383Yes
10981838183.0241.44241.4AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. R W CoxComput Biomed Res19968812068Yes
11080978097.0198.52198.5Solvent content of protein crystals. B W MatthewsJ Mol Biol19685700707Yes
111238347944.7700.82233.6The PHQ-9: validity of a brief depression severity measure. K Kroenke, R L Spitzer, J B WilliamsJ Gen Intern Med200111556941Yes
11279137913.0365.6365.6Comparative fit indexes in structural models. P M BentlerPsychol Bull19902320703Yes
11378627862.0217.36217.4"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. W N BurnetteAnal Biochem19816266278Yes
114156287814.0381.3190.7MrBayes 3: Bayesian phylogenetic inference under mixed models. Fredrik Ronquist, John P HuelsenbeckBioinformatics200312912839Yes
11577937793.0225.86225.9A simplification of the protein assay method of Lowry et al. which is more generally applicable. G L PetersonAnal Biochem1977603028Yes
11677867786.0216.07216.1The role of protein kinase C in cell surface signal transduction and tumour promotion. Y NishizukaNature19846232463No
11777807780.0210.29210.3Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. F TajimaGenetics19892513255Yes
118154637731.5346.88173.4Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. S J Clough, A F BentPlant J199810069079Yes
11976987698.0151.21151.2Tumor angiogenesis: therapeutic implications. J FolkmanN Engl J Med19714938153No
12076327632.0214.54214.5Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. J R VaneNat New Biol19715284360Yes
12176317631.0222.12222.1Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. A BöyumScand J Clin Lab Invest Suppl19684179068Yes
12275847584.0187.2187.2Fast robust automated brain extraction. Stephen M SmithHum Brain Mapp200212391568No
12375367536.0160.91160.9Chromatin modifications and their function. Tony KouzaridesCell200717320507No
124150317515.5505.14252.6Three approaches to qualitative content analysis. Hsiu-Fang Hsieh, Sarah E ShannonQual Health Res200516204405Yes
125224857495.0879.35293.1Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. W T Friedewald, R I Levy, D S FredricksonClin Chem19724337382Yes
126149327466.0355.57177.8BEDTools: a flexible suite of utilities for comparing genomic features. Aaron R Quinlan, Ira M HallBioinformatics201020110278Yes
127223017433.7674.64224.9Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Daniel Dindo, Nicolas Demartines, Pierre-Alain ClavienAnn Surg200415273542Yes
12873647364.0124.24124.2A low-viscosity epoxy resin embedding medium for electron microscopy. A R SpurrJ Ultrastruct Res19694887011Yes
129147287364.0453.29226.6AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Oleg Trott, Arthur J OlsonJ Comput Chem201019499576Yes
130515477363.91327.76189.7Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J LipmanNucleic Acids Res19979254694No
13173547354.0243.01243.0Density-functional approximation for the correlation energy of the inhomogeneous electron gas. J P PerdewPhys Rev B Condens Matter19869938299Yes
13272567256.0229.66229.7The Clinical Dementia Rating (CDR): current version and scoring rules. J C MorrisNeurology19938232972Yes
13371857185.0216.85216.8The VideoToolbox software for visual psychophysics: transforming numbers into movies. D G PelliSpat Vis19979176953Yes
134283547088.5927.09231.8G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel BuchnerBehav Res Methods200717695343Yes
13570547054.0192.17192.2TreeView: an application to display phylogenetic trees on personal computers. R D PageComput Appl Biosci19968902363Yes
136487936970.47232.281033.2Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie BrayCA Cancer J Clin202133538338Yes
13769706970.0245.14245.1The Strengths and Difficulties Questionnaire: a research note. R GoodmanJ Child Psychol Psychiatry19979255702Yes
138137396869.5352.1176.1Continuous cultures of fused cells secreting antibody of predefined specificity. G Köhler, C MilsteinNature19751172191Yes
13968376837.0183.54183.5The steroid and thyroid hormone receptor superfamily. R M EvansScience19883283939No
14067046704.00.00.0The thiobarbituric acid assay of sialic acids. L WarrenJ Biol Chem195913672998Yes
141132036601.5714.81357.4Intraclass correlations: uses in assessing rater reliability. P E Shrout, J L FleissPsychol Bull197918839484No
14265966596.0173.78173.8A modified poisson regression approach to prospective studies with binary data. Guangyong ZouAm J Epidemiol200415033648Yes
143131636581.5309.7154.8WGCNA: an R package for weighted correlation network analysis. Peter Langfelder, Steve HorvathBMC Bioinformatics200819114008Yes
144131446572.0308.14154.1Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Y Cheng, W H PrusoffBiochem Pharmacol19734202581Yes
14565666566.0214.32214.3Ethical guidelines for investigations of experimental pain in conscious animals. Manfred ZimmermannPain19836877845No
146196636554.3551.12183.7A new generation of Ca2+ indicators with greatly improved fluorescence properties. G Grynkiewicz, M Poenie, R Y TsienJ Biol Chem19853838314Yes
147130926546.00.00.0Statistical aspects of the analysis of data from retrospective studies of disease. N Mantel, W HaenszelJ Natl Cancer Inst195913655060Yes
14865446544.0172.27172.3Adhesion receptors of the immune system. T A SpringerNature19901974032No
14965216521.0129.37129.4Integrins: bidirectional, allosteric signaling machines. Richard O HynesCell200212297042No
15065116511.0169.07169.1Angiogenesis in cancer, vascular, rheumatoid and other disease. J FolkmanNat Med19957584949No
151129636481.5358.79179.4EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Arnaud Delorme, Scott MakeigJ Neurosci Methods200415102499Yes
15263966396.0128.93128.9Rapid and efficient site-specific mutagenesis without phenotypic selection. T A KunkelProc Natl Acad Sci U S A19853881765Yes
15363626362.0150.07150.1Inflammation, atherosclerosis, and coronary artery disease. Göran K HanssonN Engl J Med200515843671No
15463596359.00.00.0Index for rating diagnostic tests. W J YoudenCancer195015405679Yes
15563526352.0112.44112.4A Self-Rating Depression Scale. W W ZungArch Gen Psychiatry196514221692Yes
15663476347.0135.17135.2p53, the cellular gatekeeper for growth and division. A J LevineCell19979039259No
157125906295.0524.48262.2Prediction of creatinine clearance from serum creatinine. D W Cockcroft, M H GaultNephron19761244564Yes
158125786289.0430.87215.4The meaning and use of the area under a receiver operating characteristic (ROC) curve. J A Hanley, B J McNeilRadiology19827063747Yes
15962456245.0215.33215.3An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. Peter C AustinMultivariate Behav Res201121818162Yes
16062266226.0135.92135.9Inflammation in atherosclerosis. Peter LibbyNature200212490960No
16162036203.0146.11146.1Biochemistry and molecular cell biology of diabetic complications. M BrownleeNature200111742414Yes
162123956197.5345.13172.6RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. Bo Li, Colin N DeweyBMC Bioinformatics201121816040Yes
16361846184.0144.55144.6Free radicals in the physiological control of cell function. Wulf DrögePhysiol Rev200211773609No
16461606160.0141.49141.5Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. J CastresanaMol Biol Evol200010742046Yes
165122466123.0434.36217.2A rapid alkaline extraction procedure for screening recombinant plasmid DNA. H C Birnboim, J DolyNucleic Acids Res1979388356Yes
166183226107.3907.93302.6Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. H Ohkawa, N Ohishi, K YagiAnal Biochem197936810Yes
16760996099.0114.18114.2BLAT--the BLAST-like alignment tool. W James KentGenome Res200211932250Yes
16860856085.0149.01149.0Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. T A SpringerCell19947507411No
16960306030.0152.48152.5G proteins: transducers of receptor-generated signals. A G GilmanAnnu Rev Biochem19873113327No
17060266026.0151.93151.9Inositol trisphosphate and calcium signalling. M J BerridgeNature19938381210No
171239675991.8771.37192.8Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. J M Chirgwin, A E Przybyla, R J MacDonald, W J RutterBiochemistry1979518835Yes
17259885988.0144.59144.6Inflammation and metabolic disorders. Gökhan S HotamisligilNature200617167474No
173119135956.5289.39144.7MRBAYES: Bayesian inference of phylogenetic trees. J P Huelsenbeck, F RonquistBioinformatics200111524383Yes
174118435921.5805.27402.6A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. Terry K Koo, Mae Y LiJ Chiropr Med201627330520Yes
17559165916.0136.69136.7Antimicrobial peptides of multicellular organisms. Michael ZasloffNature200211807545Yes
176174545818.0612.94204.3Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Allison Tong, Peter Sainsbury, Jonathan CraigInt J Qual Health Care200717872937Yes
177116325816.0267.43133.7Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. W Kabsch, C SanderBiopolymers19836667333Yes
17857995799.0178.45178.4Modification of seizure activity by electrical stimulation. II. Motor seizure. R J RacineElectroencephalogr Clin Neurophysiol19724110397Yes
179115825791.0316.21158.1Neuropathological stageing of Alzheimer-related changes. H Braak, E BraakActa Neuropathol19911759558No
180115625781.0252.29126.1One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. K A Datsenko, B L WannerProc Natl Acad Sci U S A200010829079Yes
18157635763.075.4675.5The Environment And Disease: Association Or Causation? A B HillProc R Soc Med196514283879Yes
18257415741.0255.35255.3Interrater reliability: the kappa statistic. Mary L McHughBiochem Med (Zagreb)201223092060Yes
18357015701.0142.96143.0Apoptosis in the pathogenesis and treatment of disease. C B ThompsonScience19957878464No
184113945697.0470.31235.2The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. T Omura, R SatoJ Biol Chem196414209971Yes
185113765688.0251.0125.5Dendritic cells and the control of immunity. J Banchereau, R M SteinmanNature19989521319No
186113495674.5299.6149.8Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. Florian Weigend, Reinhart AhlrichsPhys Chem Chem Phys200516240044Yes
18756655665.0158.26158.3A fast diffeomorphic image registration algorithm. John AshburnerNeuroimage200717761438Yes
18856315631.0124.76124.8MUSCLE: a multiple sequence alignment method with reduced time and space complexity. Robert C EdgarBMC Bioinformatics200415318951Yes
189112485624.00.00.0A series of normal stages in the development of the chick embryo. V Hamburger, H L HamiltonJ Morphol195124539719Yes
19056185618.0177.98178.0jModelTest: phylogenetic model averaging. David PosadaMol Biol Evol200818397919Yes
19155835583.00.00.0Aging: a theory based on free radical and radiation chemistry. D HarmanJ Gerontol195613332224Yes
19255635563.0133.23133.2Development of a rating scale for primary depressive illness. M HamiltonBr J Soc Clin Psychol19676080235Yes
19355565556.0106.74106.7Evaluation of survival data and two new rank order statistics arising in its consideration. N MantelCancer Chemother Rep19665910392Yes
19455455545.0220.6220.6Orienting of attention. M I PosnerQ J Exp Psychol19807367577Yes
19555435543.092.6792.7Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. F TietzeAnal Biochem19694388022Yes
19655145514.0119.69119.7The biochemistry of apoptosis. M O HengartnerNature200011048727No
19755055505.0181.05181.1Whatever happened to qualitative description? M SandelowskiRes Nurs Health200010940958No
198109945497.0255.79127.9A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Stéphane Guindon, Olivier GascuelSyst Biol200314530136Yes
19954945494.092.8892.9Mutation and cancer: statistical study of retinoblastoma. A G KnudsonProc Natl Acad Sci U S A19715279523Yes
200164255475.0493.61164.5A simple salting out procedure for extracting DNA from human nucleated cells. S A Miller, D D Dykes, H F PoleskyNucleic Acids Res19883344216Yes
201109255462.5287.33143.7Sequencing end-labeled DNA with base-specific chemical cleavages. A M Maxam, W GilbertMethods Enzymol19806246368Yes
202108665433.0230.45115.2Inflammation and cancer. Lisa M Coussens, Zena WerbNature200212490959No
203108615430.5962.87481.4Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. Zunyou Wu, Jennifer M McGooganJAMA202032091533Yes
20454185418.0259.44259.4Minimap2: pairwise alignment for nucleotide sequences. Heng LiBioinformatics201829750242Yes
205107975398.5276.16138.1Differential expression analysis for sequence count data. Simon Anders, Wolfgang HuberGenome Biol201020979621Yes
206107825391.0357.57178.8Operating characteristics of a rank correlation test for publication bias. C B Begg, M MazumdarBiometrics19947786990Yes
207107045352.0299.8149.9MODELTEST: testing the model of DNA substitution. D Posada, K A CrandallBioinformatics19989918953Yes
20853455345.0158.07158.1Developments of a water-maze procedure for studying spatial learning in the rat. R MorrisJ Neurosci Methods19846471907Yes
20953415341.0163.48163.5Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. Ilan H MeyerPsychol Bull200312956539No
21053355335.0137.26137.3The Cambridge Structural Database: a quarter of a million crystal structures and rising. Frank H AllenActa Crystallogr B200212037359Yes
21153125312.0139.99140.0Mild cognitive impairment as a diagnostic entity. R C PetersenJ Intern Med200415324362No
21252975297.0134.85134.8New M13 vectors for cloning. J MessingMethods Enzymol19836310323Yes
213264385287.6714.2142.8The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G HigginsNucleic Acids Res19979396791Yes
21452775277.0127.68127.7The NF-kappa B and I kappa B proteins: new discoveries and insights. A S BaldwinAnnu Rev Immunol19968717528No
21552755275.0102.73102.7Epithelial-mesenchymal transitions in tumour progression. Jean Paul ThieryNat Rev Cancer200212189386No
216158065268.7592.37197.5The positive and negative syndrome scale (PANSS) for schizophrenia. S R Kay, A Fiszbein, L A OplerSchizophr Bull19873616518Yes
21752625262.0151.99152.0Studies and perspectives of protein kinase C. Y NishizukaScience19863014651No
218105235261.5490.38245.2A new depression scale designed to be sensitive to change. S A Montgomery, M AsbergBr J Psychiatry1979444788Yes
219105105255.00.00.0A quantitative description of membrane current and its application to conduction and excitation in nerve. A L Hodgkin, A F HuxleyJ Physiol195212991237Yes
22052315231.0142.71142.7How mitochondria produce reactive oxygen species. Michael P MurphyBiochem J200919061483No
22152215221.00.00.0[A micro-method of immuno-electrophoresis]. J J ScheideggerInt Arch Allergy Appl Immunol195513262900Yes
22252165216.0118.08118.1Tandem repeats finder: a program to analyze DNA sequences. G BensonNucleic Acids Res19999862982Yes
22352105210.0198.14198.1Revisiting the behavioral model and access to medical care: does it matter? R M AndersenJ Health Soc Behav19957738325Yes
22452085208.0189.17189.2Oxygen-derived free radicals in postischemic tissue injury. J M McCordN Engl J Med19852981404No
22551925192.053.3853.4The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. P LaurenActa Pathol Microbiol Scand196514320675Yes
22651915191.066.1466.1Selective extraction of polyoma DNA from infected mouse cell cultures. B HirtJ Mol Biol19674291934Yes
227103705185.0226.84113.4MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Jürgen Cox, Matthias MannNat Biotechnol200819029910Yes
228155225174.0382.52127.5Inference of population structure using multilocus genotype data. J K Pritchard, M Stephens, P DonnellyGenetics200010835412Yes
229102975148.5365.38182.7The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. R F Furchgott, J V ZawadzkiNature19806253831Yes
23051205120.0124.58124.6Emotion circuits in the brain. J E LeDouxAnnu Rev Neurosci200010845062No
23150985098.0101.69101.7Rho GTPases and the actin cytoskeleton. A HallScience19989438836No
232101955097.5270.9135.4Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. H Schägger, G von JagowAnal Biochem19872449095Yes
233101805090.0241.91121.0Comparative protein modelling by satisfaction of spatial restraints. A Sali, T L BlundellJ Mol Biol19938254673Yes
23450805080.0186.76186.8Analyzing Tables Of Statistical Tests. William R RiceEvolution198928568501Yes
235101385069.0220.24110.1The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. John Hardy, Dennis J SelkoeScience200212130773No
23650665066.0102.02102.0Targeting HIF-1 for cancer therapy. Gregg L SemenzaNat Rev Cancer200313130303No
23750295029.0196.67196.7The need for a new medical model: a challenge for biomedicine. G L EngelScience1977847460Yes
238200715017.8512.79128.2Features and development of Coot. P Emsley, B Lohkamp, W G Scott, K CowtanActa Crystallogr D Biol Crystallogr201020383002Yes
239299604993.31046.91174.5Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G CondeJ Biomed Inform200918929686Yes
240149344978.0538.75179.6Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. S M Hsu, L Raine, H FangerJ Histochem Cytochem19816166661Yes
241248204964.01079.21215.8MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir KumarMol Biol Evol201324132122Yes
242148654955.01042.78347.6Cancer statistics, 2019. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201930620402Yes
24349514951.0130.14130.1A protein binding assay for adenosine 3':5'-cyclic monophosphate. A G GilmanProc Natl Acad Sci U S A19704318781Yes
24449514951.0230.19230.2Executive functions. Adele DiamondAnnu Rev Psychol201323020641No
24598494924.5234.75117.4A genetic model for colorectal tumorigenesis. E R Fearon, B VogelsteinCell19902188735No
24649104910.0140.44140.4Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. C B LaurellAnal Biochem19665959431Yes
24748984898.0115.21115.2The clonal evolution of tumor cell populations. P C NowellScience1976959840Yes
24897954897.5351.09175.5Ligand: a versatile computerized approach for characterization of ligand-binding systems. P J Munson, D RodbardAnal Biochem19806254391Yes
249146064868.7392.87131.0Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. C Yanisch-Perron, J Vieira, J MessingGene19852985470Yes
25048414841.097.6697.7An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. M KozakNucleic Acids Res19873313277No
25148274827.090.3990.4DNA methylation patterns and epigenetic memory. Adrian BirdGenes Dev200211782440No
252144564818.71291.32430.4Cancer statistics, 2020. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin202031912902Yes
25348184818.0146.64146.6Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. W H HarrisJ Bone Joint Surg Am19695783851Yes
254144494816.3357.37119.1A comprehensive set of sequence analysis programs for the VAX. J Devereux, P Haeberli, O SmithiesNucleic Acids Res19846546423Yes
255240694813.8408.8481.8An inventory for measuring depression. A T Beck, C H Ward, M Mendelson, J Mock, J ErbaughArch Gen Psychiatry196113688369Yes
25695974798.5259.34129.7The rise of graphene. A K Geim, K S NovoselovNat Mater200717330084Yes
25747934793.0176.02176.0FreeSurfer. Bruce FischlNeuroimage201222248573No
258143744791.30.00.0Determination of serum proteins by means of the biuret reaction. A G Gornall, C J Bardawill, M M DavidJ Biol Chem194918110453Yes
25947844784.0142.47142.5Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. M RodbellJ Biol Chem196414169133Yes
26047724772.0107.05107.0ras oncogenes in human cancer: a review. J L BosCancer Res19892547513No
26147604760.0104.65104.7Cancer cell cycles. C J SherrScience19968939849No
26295004750.0158.3979.2A new technique for the assay of infectivity of human adenovirus 5 DNA. F L Graham, A J van der EbVirology19734705382Yes
26394654732.5209.98105.0Parkinsonism: onset, progression and mortality. M M Hoehn, M D YahrNeurology19676067254Yes
26494574728.5173.1286.6Assessment of older people: self-maintaining and instrumental activities of daily living. M P Lawton, E M BrodyGerontologist19695349366Yes
26594234711.5156.4178.2Functional Evaluation: The Barthel Index. F I Mahoney, D W BarthelMd State Med J196514258950Yes
26694154707.5237.04118.5Improved tools for biological sequence comparison. W R Pearson, D J LipmanProc Natl Acad Sci U S A19883162770Yes
26794094704.5320.03160.0Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. U H Graneheim, B LundmanNurse Educ Today200414769454No
268141044701.3558.31186.1A global measure of perceived stress. S Cohen, T Kamarck, R MermelsteinJ Health Soc Behav19836668417Yes
26946984698.0156.98157.0The pathogenesis of atherosclerosis--an update. R RossN Engl J Med19863511384No
27046814681.0103.16103.2Alzheimer's disease: genes, proteins, and therapy. D J SelkoePhysiol Rev200111274343No
27146804680.0210.74210.7The McGill Pain Questionnaire: major properties and scoring methods. Ronald MelzackPain19751235985Yes
272140374679.0485.25161.8Nitric oxide: physiology, pathophysiology, and pharmacology. S Moncada, R M Palmer, E A HiggsPharmacol Rev19911852778No
273140334677.7306.52102.2Refinement of macromolecular structures by the maximum-likelihood method. G N Murshudov, A A Vagin, E J DodsonActa Crystallogr D Biol Crystallogr199715299926Yes
27446734673.0130.02130.0Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. P MatsudairaJ Biol Chem19873611052Yes
27546694669.076.3176.3Aggregation of blood platelets by adenosine diphosphate and its reversal. G V BornNature196213871375Yes
27646434643.0118.52118.5A rapid banding technique for human chromosomes. M SeabrightLancet19714107917Yes
277185494637.2533.24133.3MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir KumarMol Biol Evol200717488738Yes
27846364636.0102.91102.9Prions. S B PrusinerProc Natl Acad Sci U S A19989811807No
27992704635.0253.19126.6Ab initio molecular dynamics for liquid metals. G Kresse, J HafnerPhys Rev B Condens Matter199310004490Yes
280185064626.5298.5174.6A new and rapid colorimetric determination of acetylcholinesterase activity. G L Ellman, K D Courtney, V Andres, R M Feather-StoneBiochem Pharmacol196113726518Yes
28192464623.0336.93168.5Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Kristopher J Preacher, Andrew F HayesBehav Res Methods200818697684Yes
28246224622.040.4240.4The Limited In Vitro Lifetime Of Human Diploid Cell Strains. L HayflickExp Cell Res196514315085Yes
28345764576.0142.5142.5Updating P300: an integrative theory of P3a and P3b. John PolichClin Neurophysiol200717573239No
284137124570.7601.68200.6Development and validation of brief measures of positive and negative affect: the PANAS scales. D Watson, L A Clark, A TellegenJ Pers Soc Psychol19883397865Yes
28591304565.0202.84101.4Primer3 on the WWW for general users and for biologist programmers. S Rozen, H SkaletskyMethods Mol Biol200010547847Yes
28691124556.0139.4869.7Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J M McCord, I FridovichJ Biol Chem19695389100Yes
28745494549.093.6693.7Alternative activation of macrophages. Siamon GordonNat Rev Immunol200312511873No
28890984549.0374.87187.4phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. Paul J McMurdie, Susan HolmesPLoS One201323630581Yes
28945204520.097.0297.0ras genes. M BarbacidAnnu Rev Biochem19873304147No
29044974497.0117.91117.9The genetical evolution of social behaviour. I. W D HamiltonJ Theor Biol19645875341Yes
29189604480.0214.18107.1Collective dynamics of 'small-world' networks. D J Watts, S H StrogatzNature19989623998Yes
29289414470.50.00.0A simplified method of evaluating dose-effect experiments. J T Litchfield, F WilcoxonJ Pharmacol Exp Ther194918152921Yes
29344704470.090.2190.2Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. M KozakCell19863943125Yes
29444664466.0102.57102.6Cancer. p53, guardian of the genome. D P LaneNature19921614522No
295267324455.3923.26153.9Global cancer statistics. Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David FormanCA Cancer J Clin201121296855Yes
29644544454.0105.87105.9Why most published research findings are false. John P A IoannidisPLoS Med200516060722Yes
29744374437.0107.73107.7A new method for predicting signal sequence cleavage sites. G von HeijneNucleic Acids Res19863714490Yes
29888684434.0237.41118.7A synaptic model of memory: long-term potentiation in the hippocampus. T V Bliss, G L CollingridgeNature19938421494No
299132364412.0476.23158.7HTSeq--a Python framework to work with high-throughput sequencing data. Simon Anders, Paul Theodor Pyl, Wolfgang HuberBioinformatics201525260700Yes
300132304410.0422.58140.9Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. E R DeLong, D M DeLong, D L Clarke-PearsonBiometrics19883203132Yes
30143984398.090.3390.3Wnt/beta-catenin signaling in development and disease. Hans CleversCell200617081971No
30287804390.0220.1110.0Assessment of coma and impaired consciousness. A practical scale. G Teasdale, B JennettLancet19744136544Yes
30387734386.5202.91101.5SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. N Guex, M C PeitschElectrophoresis19979504803Yes
30487674383.5161.0880.5A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. W M Bonner, R A LaskeyEur J Biochem19744850204Yes
30543784378.083.5883.6The phosphoinositide 3-kinase pathway. Lewis C CantleyScience200212040186No
30643524352.0221.49221.5Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. M M MesulamJ Histochem Cytochem197824068Yes
307260554342.5954.22159.0MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir KumarMol Biol Evol201121546353Yes
30843414341.081.3981.4The detection of disease clustering and a generalized regression approach. N MantelCancer Res19676018555Yes
309130134337.7634.08211.4Cancer statistics, 2016. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201626742998Yes
31043364336.0111.92111.9Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Y NishizukaScience19921411571No
31143354335.0158.06158.1EuroQol: the current state of play. R BrooksHealth Policy199610158943No
312129524317.3560.52186.8Deep learning. Yann LeCun, Yoshua Bengio, Geoffrey HintonNature201526017442No
31343164316.0101.5101.5Mechanisms of angiogenesis. W RisauNature19979109485No
31486314315.5320.8160.4The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. I F Benzie, J J StrainAnal Biochem19968660627Yes
31586234311.5248.97124.5Estimating F-Statistics For The Analysis Of Population Structure. B S Weir, C Clark CockerhamEvolution198428563791Yes
31643064306.0128.81128.8Glutamate neurotoxicity and diseases of the nervous system. D W ChoiNeuron19882908446No
317171914297.8515.25128.8clusterProfiler: an R package for comparing biological themes among gene clusters. Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu HeOMICS201222455463Yes
31885934296.5355.88177.9The timed "Up & Go": a test of basic functional mobility for frail elderly persons. D Podsiadlo, S RichardsonJ Am Geriatr Soc19911991946Yes
31985874293.5124.4762.2Preparation of iodine-131 labelled human growth hormone of high specific activity. W M Hunter, F C GreenwoodNature196214450081Yes
320128514283.7758.01252.7Cancer statistics, 2018. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201829313949Yes
321128254275.0420.8140.3featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Yang Liao, Gordon K Smyth, Wei ShiBioinformatics201424227677Yes
32242724272.0113.28113.3The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Y NishizukaNature19883045562No
323170774269.2537.67134.4A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge KriegJ Chem Phys201020423165Yes
32442634263.092.4592.5Apoptosis by death factor. S NagataCell19979039262No
32542594259.00.00.0New methods for calculating metabolic rate with special reference to protein metabolism. J B De B WeirJ Physiol194915394301Yes
32685144257.00.00.0Radiological assessment of osteo-arthrosis. J H Kellgren, J S LawrenceAnn Rheum Dis195713498604Yes
32742504250.090.4390.4Protein production by auto-induction in high density shaking cultures. F William StudierProtein Expr Purif200515915565Yes
32842444244.0159.04159.0Measuring the accuracy of diagnostic systems. J A SwetsScience19883287615No
32942414241.00.00.0Estimation of nuclear population from microtome sections. M AbercrombieAnat Rec194621015608Yes
33042364236.00.00.0The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. T NashBiochem J195313105648Yes
33142324232.087.5287.5The retinoblastoma protein and cell cycle control. R A WeinbergCell19957736585No
33242294229.00.00.0Evolution in Mendelian Populations. S WrightGenetics193117246615Yes
33342224222.00.00.0Amino acid metabolism in mammalian cell cultures. H EagleScience195913675766Yes
33442184218.0109.75109.8Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. A H WyllieNature19806245367Yes
33542164216.093.9193.9Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. S HenikoffGene19846235151Yes
336252784213.0824.85137.5Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C TurnerDiabetologia19853899825Yes
33742094209.091.4691.5Atherosclerosis. A J LusisNature200011001066No
33841994199.075.7675.8Generalized lacZ expression with the ROSA26 Cre reporter strain. P SorianoNat Genet19999916792Yes
33941984198.00.00.0A relation between non-esterified fatty acids in plasma and the metabolism of glucose. V P DoleJ Clin Invest195613286333Yes
34041814181.087.1687.2Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. C J MarshallCell19957834738No
34183554177.5224.01112.0Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii. Daniel E Voth, Robert A HeinzenCell Microbiol200717381428No
342292104172.9643.3791.9UCSF Chimera--a visualization system for exploratory research and analysis. Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E FerrinJ Comput Chem200415264254Yes
343124954165.0463.75154.6A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. J Ware, M Kosinski, S D KellerMed Care19968628042Yes
34441624162.092.2992.3PAML: a program package for phylogenetic analysis by maximum likelihood. Z YangComput Appl Biosci19979367129Yes
34541624162.0108.69108.7Staphylococcus aureus infections. F D LowyN Engl J Med19989709046No
34683224161.0306.93153.5Multiwfn: a multifunctional wavefunction analyzer. Tian Lu, Feiwu ChenJ Comput Chem201222162017Yes
34741514151.050.4450.4Bone: formation by autoinduction. M R UristScience19655319761Yes
348165944148.5621.7155.4Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanAnn Intern Med200919622511No
34941404140.0173.18173.2Determination of protein: a modification of the Lowry method that gives a linear photometric response. E F HartreeAnal Biochem19724115981Yes
35082804140.0177.888.9Genomic sequencing. G M Church, W GilbertProc Natl Acad Sci U S A19846326095Yes
35141344134.00.00.0The determination of enzyme inhibitor constants. M DixonBiochem J195313093635Yes
35282624131.0213.46106.7Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. D E Paglia, W N ValentineJ Lab Clin Med19676066618Yes
35341064106.0194.66194.7Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Daniël LakensFront Psychol201324324449No
35482084104.0262.33131.2DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. P Librado, J RozasBioinformatics200919346325Yes
35540994099.0127.29127.3Emerging adulthood. A theory of development from the late teens through the twenties. J J ArnettAm Psychol200010842426Yes
35640924092.0128.48128.5Bacterial evolution. C R WoeseMicrobiol Rev19872439888No
35740924092.0150.49150.5A concordance correlation coefficient to evaluate reproducibility. L I LinBiometrics19892720055Yes
35840654065.084.3884.4The green fluorescent protein. R Y TsienAnnu Rev Biochem19989759496No
35940604060.0173.31173.3A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. E PfeifferJ Am Geriatr Soc19751159263Yes
36040484048.0101.75101.8The Scree Test For The Number Of Factors. R B CattellMultivariate Behav Res196626828106Yes
36180894044.5206.93103.5tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. T M Lowe, S R EddyNucleic Acids Res19979023104Yes
362121284042.7627.13209.0Cancer Statistics, 2017. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201728055103Yes
363363664040.7921.14102.3The Sequence Alignment/Map format and SAMtools. Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard DurbinBioinformatics200919505943Yes
36440404040.0127.26127.3How do you feel--now? The anterior insula and human awareness. A D Bud CraigNat Rev Neurosci200919096369No
36540264026.0109.01109.0Mesenchymal stem cells. A I CaplanJ Orthop Res19911870029Yes
36640214021.0136.51136.5Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. J CohenPsychol Bull196819673146Yes
36740164016.078.7578.8Hypoxia--a key regulatory factor in tumour growth. Adrian L HarrisNat Rev Cancer200211902584No
368159983999.5582.26145.6Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanBMJ200919622551No
36939983998.0103.55103.5Integrins: a family of cell surface receptors. R O HynesCell19873028640No
370119723990.7453.36151.1HISAT: a fast spliced aligner with low memory requirements. Daehwan Kim, Ben Langmead, Steven L SalzbergNat Methods201525751142Yes
37139863986.070.1570.2Principles that govern the folding of protein chains. C B AnfinsenScience19734124164Yes
37239843984.0106.86106.9What is the evidence that tumors are angiogenesis dependent? J FolkmanJ Natl Cancer Inst19901688381No
37379663983.0221.1110.5Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. S Duval, R TweedieBiometrics200010877304Yes
37439713971.0128.17128.2Tissue destruction by neutrophils. S J WeissN Engl J Med19892536474No
37539673967.00.00.0Staining of tissue sections for electron microscopy with heavy metals. M L WatsonJ Biophys Biochem Cytol195813563554Yes
37639643964.0115.56115.6Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. D VanderbiltPhys Rev B Condens Matter19909993096Yes
37739603960.097.2297.2Multiple sequence alignment with hierarchical clustering. F CorpetNucleic Acids Res19882849754Yes
37879053952.5149.2574.6A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. R S Sikorski, P HieterGenetics19892659436Yes
379118303943.3302.32100.8Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. W H Habig, M J Pabst, W B JakobyJ Biol Chem19744436300Yes
38039433943.099.8299.8Oxidative stress, antioxidants and stress tolerance. Ron MittlerTrends Plant Sci200212234732No
38178653932.5200.06100.0Control of goal-directed and stimulus-driven attention in the brain. Maurizio Corbetta, Gordon L ShulmanNat Rev Neurosci200211994752No
38278463923.0219.14109.6Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. H Aviv, P LederProc Natl Acad Sci U S A19724504350Yes
38339163916.0103.52103.5Observational study of behavior: sampling methods. J AltmannBehaviour19744597405No
38439133913.0104.12104.1Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. R B D'AgostinoStat Med19989802183Yes
38539133913.0155.55155.6Disc Electrophoresis. I. Background And Theory. L OrnsteinAnn N Y Acad Sci196414240533Yes
38639033903.0120.51120.5Nitric oxide as a secretory product of mammalian cells. C NathanFASEB J19921381691No
38739003900.084.8784.9Folding DNA to create nanoscale shapes and patterns. Paul W K RothemundNature200616541064Yes
388116883896.0316.02105.3Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. J F Kerr, A H Wyllie, A R CurrieBr J Cancer19724561027No
38938943894.083.9584.0Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Rakesh K JainScience200515637262No
39038833883.080.2480.2Protein secondary structure prediction based on position-specific scoring matrices. D T JonesJ Mol Biol199910493868Yes
39138783878.0119.31119.3Pharmacological implications of microsomal enzyme induction. A H ConneyPharmacol Rev19674383307Yes
39238723872.0128.65128.7Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Russell A BarkleyPsychol Bull19979000892No
39377373868.5146.1273.1Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. A H Brand, N PerrimonDevelopment19938223268Yes
39477213860.5190.3395.2Fast and accurate long-read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics201020080505Yes
39538563856.0130.57130.6Preparation of isolated rat liver cells. P O SeglenMethods Cell Biol1976177845No
39638373837.0101.88101.9Drug combination studies and their synergy quantification using the Chou-Talalay method. Ting-Chao ChouCancer Res201020068163Yes
39738373837.0108.58108.6Functions of DNA methylation: islands, start sites, gene bodies and beyond. Peter A JonesNat Rev Genet201222641018No
398153463836.5358.4589.6Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Ben Langmead, Cole Trapnell, Mihai Pop, Steven L SalzbergGenome Biol200919261174Yes
39976493824.5255.33127.7FLASH: fast length adjustment of short reads to improve genome assemblies. Tanja Magoč, Steven L SalzbergBioinformatics201121903629Yes
40038243824.097.1497.1Sequencing technologies - the next generation. Michael L MetzkerNat Rev Genet201019997069No
40138233823.091.1691.2Caspases: the executioners of apoptosis. G M CohenBiochem J19979337844No
40238233823.097.6697.7Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Kim A BrogdenNat Rev Microbiol200515703760No
403190893817.8740.93148.2The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. D J Buysse, C F Reynolds, T H Monk, S R Berman, D J KupferPsychiatry Res19892748771Yes
40438163816.095.3995.4The origins and the future of microfluidics. George M WhitesidesNature200616871203No
40538123812.093.9594.0Origin and physiological roles of inflammation. Ruslan MedzhitovNature200818650913No
40638113811.0103.22103.2Revisions in the International System for Staging Lung Cancer. C F MountainChest19979187198Yes
40738013801.084.4384.4Instability and decay of the primary structure of DNA. T LindahlNature19938469282No
40837933793.073.9574.0Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. G R MartinProc Natl Acad Sci U S A19816950406Yes
40937923792.080.4780.5A catalogue of splice junction sequences. S M MountNucleic Acids Res19827063411Yes
41037913791.080.6680.7Scaling and assessment of data quality. Philip EvansActa Crystallogr D Biol Crystallogr200616369096No
41137693769.0109.03109.0What's wrong with Bonferroni adjustments. T V PernegerBMJ19989553006No
41275303765.0181.6290.8Mitochondria and apoptosis. D R Green, J C ReedScience19989721092No
41337653765.077.4577.5TGF-beta signal transduction. J MassaguéAnnu Rev Biochem19989759503No
41475203760.0209.45104.7BEAST: Bayesian evolutionary analysis by sampling trees. Alexei J Drummond, Andrew RambautBMC Evol Biol200717996036Yes
41537593759.0118.65118.7genepop'007: a complete re-implementation of the genepop software for Windows and Linux. François RoussetMol Ecol Resour200821585727Yes
41637573757.0158.33158.3Estimation of the molecular weights of proteins by Sephadex gel-filtration. P AndrewsBiochem J19644158310Yes
41737533753.087.2287.2Novel proteinaceous infectious particles cause scrapie. S B PrusinerScience19826801762Yes
41837493749.0107.1107.1Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. J H MorrisseyAnal Biochem19816172996Yes
41974963748.0166.0583.0Inference of macromolecular assemblies from crystalline state. Evgeny Krissinel, Kim HenrickJ Mol Biol200717681537Yes
42074933746.5189.2894.6The basics of epithelial-mesenchymal transition. Raghu Kalluri, Robert A WeinbergJ Clin Invest200919487818No
42137453745.0126.22126.2Generalized expectancies for internal versus external control of reinforcement. J B RotterPsychol Monogr19665340840No
42237453745.089.289.2Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. A T BrüngerNature199218481394Yes
42337413741.099.6399.6A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. Heng LiBioinformatics201121903627Yes
424112213740.3215.0771.7Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. J D Dignam, R M Lebovitz, R G RoederNucleic Acids Res19836828386Yes
42574803740.0300.33150.2The qualitative content analysis process. Satu Elo, Helvi KyngäsJ Adv Nurs200818352969Yes
42637353735.0170.54170.5Basic principles of ROC analysis. C E MetzSemin Nucl Med1978112681Yes
427148803720.0384.0696.0Global cancer statistics, 2002. D Max Parkin, Freddie Bray, J Ferlay, Paola PisaniCA Cancer J Clin200515761078Yes
42837033703.061.4761.5A membrane-filter technique for the detection of complementary DNA. D T DenhardtBiochem Biophys Res Commun19665963888Yes
42974043702.0177.989.0The plant immune system. Jonathan D G Jones, Jeffery L DanglNature200617108957No
43036963696.0107.58107.6Accelerated Profile HMM Searches. Sean R EddyPLoS Comput Biol201122039361Yes
43136903690.0106.31106.3Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Peter C AustinStat Med200919757444Yes
43273693684.5253.4126.7Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Laurent Excoffier, Heidi E L LischerMol Ecol Resour201021565059Yes
43336793679.0106.04106.0Protective and damaging effects of stress mediators. B S McEwenN Engl J Med19989428819No
43436753675.066.1866.2Somatic generation of antibody diversity. S TonegawaNature19836300689No
43573443672.0161.7180.9Functional rafts in cell membranes. K Simons, E IkonenNature19979177342No
43673333666.5183.7491.9An integrative theory of prefrontal cortex function. E K Miller, J D CohenAnnu Rev Neurosci200111283309No
43736653665.0102.89102.9EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. W KlimeschBrain Res Brain Res Rev199910209231No
438146593664.8468.76117.2A brief measure for assessing generalized anxiety disorder: the GAD-7. Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd LöweArch Intern Med200616717171Yes
43936633663.088.7488.7I-TASSER server for protein 3D structure prediction. Yang ZhangBMC Bioinformatics200818215316Yes
44036603660.0103.17103.2Graphene: status and prospects. A K GeimScience200919541989Yes
44136553655.085.4785.5Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Ting-Chao ChouPharmacol Rev200616968952No
44236383638.094.7494.7The adolescent brain and age-related behavioral manifestations. L P SpearNeurosci Biobehav Rev200010817843No
44336363636.0100.63100.6Biological roles of oligosaccharides: all of the theories are correct. A VarkiGlycobiology19938490246No
44436183618.091.8691.9RELION: implementation of a Bayesian approach to cryo-EM structure determination. Sjors H W ScheresJ Struct Biol201223000701Yes
445217083618.0985.55164.3Global cancer statistics, 2012. Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin JemalCA Cancer J Clin201525651787Yes
44672353617.5183.291.6The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. R C Graham, M J KarnovskyJ Histochem Cytochem19665962951Yes
44736173617.0112.62112.6DNA methylation age of human tissues and cell types. Steve HorvathGenome Biol201324138928Yes
44836023602.0108.06108.1Inositol trisphosphate and diacylglycerol as second messengers. M J BerridgeBiochem J19846146314No
44935933593.084.5884.6Marrow stromal cells as stem cells for nonhematopoietic tissues. D J ProckopScience19979082988No
450107023567.3259.0186.3Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Da Wei Huang, Brad T Sherman, Richard A LempickiNucleic Acids Res200919033363Yes
45135643564.074.674.6Profile hidden Markov models. S R EddyBioinformatics19989918945No
45235473547.070.9270.9Mammalian neural stem cells. F H GageScience200010688783No
45335363536.096.8896.9Non-coding RNAs in human disease. Manel EstellerNat Rev Genet201122094949No
45435343534.0108.46108.5Health promotion by social cognitive means. Albert BanduraHealth Educ Behav200415090118Yes
45535283528.0163.9163.9Estimation of average heterozygosity and genetic distance from a small number of individuals. M NeiGenetics197817248844Yes
45635223522.080.0480.0Nonalcoholic fatty liver disease. Paul AnguloN Engl J Med200211961152No
45770433521.5360.27180.1Microsomal lipid peroxidation. J A Buege, S D AustMethods Enzymol1978672633Yes
45835213521.066.8866.9Signal transduction by the JNK group of MAP kinases. R J DavisCell200011057897No
45935153515.080.1880.2Glutamate uptake. N C DanboltProg Neurobiol200111369436No
46070293514.5126.8663.4Translating the histone code. T Jenuwein, C D AllisScience200111498575No
46170263513.0146.1373.1A new method for sequencing DNA. A M Maxam, W GilbertProc Natl Acad Sci U S A1977265521Yes
46235113511.0104.91104.9Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. L R SquirePsychol Rev19921594723No
46335113511.084.0184.0Neural networks and physical systems with emergent collective computational abilities. J J HopfieldProc Natl Acad Sci U S A19826953413Yes
46435103510.054.254.2Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. J D RowleyNature19734126434Yes
46535063506.091.0591.0Microglia: a sensor for pathological events in the CNS. G W KreutzbergTrends Neurosci19968843599No
46635053505.0112.72112.7Modeling valuations for EuroQol health states. P DolanMed Care19979366889Yes
467175223504.4494.9999.0Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. O P Hamill, A Marty, E Neher, B Sakmann, F J SigworthPflugers Arch19816270629Yes
46834993499.055.0255.0Spectroscopic determination of tryptophan and tyrosine in proteins. H EdelhochBiochemistry19676049437Yes
46969843492.083.0841.5Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. D H Hubel, T N WieselJ Physiol196214449617Yes
47034893489.058.9358.9Statistical estimations in enzyme kinetics. G N WilkinsonBiochem J196113785321Yes
47134863486.0107.92107.9Psychometric properties of the strengths and difficulties questionnaire. R GoodmanJ Am Acad Child Adolesc Psychiatry200111699809Yes
47234833483.086.1286.1How do you feel? Interoception: the sense of the physiological condition of the body. A D CraigNat Rev Neurosci200212154366No
47369643482.0175.6187.8Long short-term memory. S Hochreiter, J SchmidhuberNeural Comput19979377276Yes
47434773477.051.951.9The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. J F WoessnerArch Biochem Biophys196113786180Yes
475104273475.7257.2585.8Understanding the Warburg effect: the metabolic requirements of cell proliferation. Matthew G Vander Heiden, Lewis C Cantley, Craig B ThompsonScience200919460998No
47634753475.084.8684.9The heat-shock response. S LindquistAnnu Rev Biochem19862427013No
47734723472.086.5186.5The pathobiology of diabetic complications: a unifying mechanism. Michael BrownleeDiabetes200515919781No
478104153471.7393.62131.2Cancer statistics, 2013. Rebecca Siegel, Deepa Naishadham, Ahmedin JemalCA Cancer J Clin201323335087Yes
47934703470.080.8380.8The dendritic cell system and its role in immunogenicity. R M SteinmanAnnu Rev Immunol19911910679No
48034633463.00.00.0The magical number seven plus or minus two: some limits on our capacity for processing information. G A MillerPsychol Rev195613310704Yes
48134573457.0135.09135.1Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. O W GriffithAnal Biochem19807416462Yes
482172533450.61194.09238.8MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro TamuraMol Biol Evol201829722887Yes
48334473447.0126.86126.9You want to measure coping but your protocol's too long: consider the brief COPE. C S CarverInt J Behav Med199716250744Yes
48434393439.093.6493.6Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. R W MahleyScience19883283935No
48568723436.0162.8181.4"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. A P Feinberg, B VogelsteinAnal Biochem19846329026Yes
48634323432.074.574.5Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. H F DvorakN Engl J Med19863537791No
487102833427.7453.68151.2Cancer statistics, 2015. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201525559415Yes
48834273427.086.6386.6Biologic basis for interleukin-1 in disease. C A DinarelloBlood19968630372No
48968473423.5135.4167.7Statistical significance for genomewide studies. John D Storey, Robert TibshiraniProc Natl Acad Sci U S A200312883005Yes
49034223422.0153.63153.6The quality of care. How can it be assessed? A DonabedianJAMA19883045356No
49167893394.5172.7986.4TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. T R Mosmann, R L CoffmanAnnu Rev Immunol19892523712No
49233863386.00.00.0Some factors in the interpretation of protein denaturation. W KauzmannAdv Protein Chem195914404936Yes
493101453381.798.3132.8The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. F C Greenwood, W M Hunter, J S GloverBiochem J196314097352Yes
49433803380.082.4382.4The basis of anisotropic water diffusion in the nervous system - a technical review. Christian BeaulieuNMR Biomed200212489094No
49567523376.0185.1192.6Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Daniel R Zerbino, Ewan BirneyGenome Res200818349386Yes
49633733373.0107.8107.8No adjustments are needed for multiple comparisons. K J RothmanEpidemiology19902081237Yes
497101123370.7360.32120.1Cancer statistics, 2012. Rebecca Siegel, Deepa Naishadham, Ahmedin JemalCA Cancer J Clin201222237781Yes
49833613361.099.8899.9adegenet: a R package for the multivariate analysis of genetic markers. Thibaut JombartBioinformatics200818397895Yes
49933583358.094.894.8Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. Thomas WeltonChem Rev199911849019Yes
50033573357.076.4776.5Tolerance, danger, and the extended family. P MatzingerAnnu Rev Immunol19948011301No
50167003350.0128.2664.1The ubiquitin system. A Hershko, A CiechanoverAnnu Rev Biochem19989759494No
50233493349.068.5768.6The scanning model for translation: an update. M KozakJ Cell Biol19892645293No
50366923346.0158.2579.1Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. C Tuerk, L GoldScience19902200121Yes
50466803340.0206.96103.5The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Stephen B Edge, Carolyn C ComptonAnn Surg Oncol201020180029No
50566643332.0142.2871.1Angiogenesis in cancer and other diseases. P Carmeliet, R K JainNature200011001068No
50633263326.068.0468.0Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. M KozakNucleic Acids Res19846694911Yes
50733203320.080.5380.5Wound healing--aiming for perfect skin regeneration. P MartinScience19979082989No
50833083308.058.1658.2Automated electron microscope tomography using robust prediction of specimen movements. David N MastronardeJ Struct Biol200516182563Yes
50933043304.083.9383.9Gene regulation by steroid hormones. M BeatoCell19892644044No
51032993299.0113.83113.8Equilibrium Ultracentrifugation Of Dilute Solutions. D A YphantisBiochemistry196414155091Yes
51132843284.064.3264.3The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Isaiah J FidlerNat Rev Cancer200312778135No
51265623281.0214.94107.5Human malaria parasites in continuous culture. W Trager, J B JensenScience1976781840Yes
51332803280.067.1967.2Alzheimer's disease is a synaptic failure. Dennis J SelkoeScience200212399581No
51432773277.089.2689.3Hay fever, hygiene, and household size. D P StrachanBMJ19892513902Yes
51565343267.0218.34109.2Management of hepatocellular carcinoma: an update. Jordi Bruix, Morris ShermanHepatology201121374666No
51665273263.5204.07102.0Complex network measures of brain connectivity: uses and interpretations. Mikail Rubinov, Olaf SpornsNeuroimage201019819337Yes
51732633263.060.1760.2Cell signaling by receptor tyrosine kinases. J SchlessingerCell200011057895No
51832593259.086.6786.7ABC transporters: from microorganisms to man. C F HigginsAnnu Rev Cell Biol19921282354No
51965123256.0177.4488.7Projections of global mortality and burden of disease from 2002 to 2030. Colin D Mathers, Dejan LoncarPLoS Med200617132052Yes
520130203255.0301.475.3Improved methods for building protein models in electron density maps and the location of errors in these models. T A Jones, J Y Zou, S W Cowan, M KjeldgaardActa Crystallogr A19912025413Yes
52132543254.073.9974.0Mitochondrial formation of reactive oxygen species. Julio F TurrensJ Physiol200314561818No
52232513251.076.2776.3Photoelectrochemical cells. M GrätzelNature200111713540Yes
52332413241.093.4193.4Inositol trisphosphate and diacylglycerol: two interacting second messengers. M J BerridgeAnnu Rev Biochem19873304132No
52432393239.0105.95106.0Transformed up-down methods in psychoacoustics. H LevittJ Acoust Soc Am19715541744Yes
52564703235.0155.1977.6Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Weizhong Li, Adam GodzikBioinformatics200616731699Yes
52664623231.0190.5895.3Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. C Beauchamp, I FridovichAnal Biochem19714943714Yes
52732293229.063.7563.8STATs and gene regulation. J E DarnellScience19979287210No
52832273227.069.569.5Activators and target genes of Rel/NF-kappaB transcription factors. H L PahlOncogene199910602461No
52932213221.097.697.6Development of a classification system for periodontal diseases and conditions. G C ArmitageAnn Periodontol199910863370No
53032193219.0103.3103.3Essential oils: their antibacterial properties and potential applications in foods--a review. Sara BurtInt J Food Microbiol200415246235No
53132043204.067.3767.4Cardiac excitation-contraction coupling. Donald M BersNature200211805843No
53232003200.065.3565.3CpG-rich islands and the function of DNA methylation. A P BirdNature19862423876No
53331973197.066.7266.7Protein folding and misfolding. Christopher M DobsonNature200314685248No
53431683168.078.3878.4The transforming growth factor-beta family. J MassaguéAnnu Rev Cell Biol19902177343No
53563273163.5152.9876.5Exploring the full spectrum of macrophage activation. David M Mosser, Justin P EdwardsNat Rev Immunol200819029990No
53631593159.0113.45113.5Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. Joseph P WeirJ Strength Cond Res200515705040No
53763093154.5133.3366.7Toll-like receptor signalling. Shizuo Akira, Kiyoshi TakedaNat Rev Immunol200415229469No
53863093154.5184.1892.1Complex brain networks: graph theoretical analysis of structural and functional systems. Ed Bullmore, Olaf SpornsNat Rev Neurosci200919190637No
53931513151.090.7390.7Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. Y X FuGenetics19979335623Yes
540283123145.8608.6367.6Cytoscape: a software environment for integrated models of biomolecular interaction networks. Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey IdekerGenome Res200314597658Yes
54131433143.096.3596.3Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Sarah E BarlowPediatrics200718055651Yes
54231413141.074.174.1WHAT IF: a molecular modeling and drug design program. G VriendJ Mol Graph19902268628Yes
54331393139.00.00.0Diffusion-in-gel methods for immunological analysis. O OuchterlonyProg Allergy195813578996Yes
54462773138.5195.8797.9Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. K Tamura, M NeiMol Biol Evol19938336541Yes
54531383138.082.2882.3Accurate Coulomb-fitting basis sets for H to Rn. Florian WeigendPhys Chem Chem Phys200616633586Yes
54662713135.5205.84102.9Measuring agreement in method comparison studies. J M Bland, D G AltmanStat Methods Med Res199910501650No
547125343133.5475.97119.0APACHE II: a severity of disease classification system. W A Knaus, E A Draper, D P Wagner, J E ZimmermanCrit Care Med19853928249Yes
54831303130.0108.99109.0The Danish Civil Registration System. Carsten Bøcker PedersenScand J Public Health201121775345Yes
54931283128.065.8865.9Angiogenesis in health and disease. Peter CarmelietNat Med200312778163No
55062553127.5101.650.8Pain mechanisms: a new theory. R Melzack, P D WallScience19655320816No
55131273127.0121.02121.0Half a century of research on the Stroop effect: an integrative review. C M MacLeodPsychol Bull19912034749No
55231263126.065.9866.0Mechanisms of angiogenesis and arteriogenesis. P CarmelietNat Med200010742145No
55393743124.7264.6188.2Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. G Evanno, S Regnaut, J GoudetMol Ecol200515969739Yes
55462433121.5151.7775.9In vitro selection of RNA molecules that bind specific ligands. A D Ellington, J W SzostakNature19901697402Yes
55531213121.026.6826.7Gene action in the X-chromosome of the mouse (Mus musculus L.). M F LyonNature196113764598Yes
55662223111.0156.8178.4Voxel-based morphometry--the methods. J Ashburner, K J FristonNeuroimage200010860804No
55793263108.7194.464.8Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Benjamin P Lewis, Christopher B Burge, David P BartelCell200515652477Yes
55862113105.553.6526.8The serial cultivation of human diploid cell strains. L Hayflick, P S MoorheadExp Cell Res196113905658Yes
55931023102.077.7277.7Cellular and molecular mechanisms of fibrosis. T A WynnJ Pathol200818161745No
56092853095.0312.14104.0Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. R M Palmer, A G Ferrige, S MoncadaNature19873495737Yes
56130923092.089.1489.1Hepatocellular carcinoma. Hashem B El-SeragN Engl J Med201121992124No
56230913091.076.176.1Recent advances with liposomes as pharmaceutical carriers. Vladimir P TorchilinNat Rev Drug Discov200515688077No
56330913091.083.5383.5The nuclear factor NF-kappaB pathway in inflammation. Toby LawrenceCold Spring Harb Perspect Biol200920457564No
56430833083.0124.16124.2Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. T E MoffittPsychol Rev19938255953No
56530833083.072.8372.8Obesity as a medical problem. P G KopelmanNature200010766250No
56661563078.0162.4381.2The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Taro Kawai, Shizuo AkiraNat Immunol201020404851No
56761533076.5136.2168.1MicroRNA signatures in human cancers. George A Calin, Carlo M CroceNat Rev Cancer200617060945No
56830743074.0105.71105.7The processing-speed theory of adult age differences in cognition. T A SalthousePsychol Rev19968759042No
56961423071.0108.6454.3The language of covalent histone modifications. B D Strahl, C D AllisNature200010638745Yes
57092133071.0224.8975.0ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Kai Wang, Mingyao Li, Hakon HakonarsonNucleic Acids Res201020601685Yes
57130703070.086.0486.0Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. S W KesslerJ Immunol19751102604Yes
572122613065.2446.0111.5Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg LangBehav Res Methods200919897823Yes
57361273063.5180.3490.2mTOR signaling in growth control and disease. Mathieu Laplante, David M SabatiniCell201222500797No
57461003050.0187.5693.8Electrochemical photolysis of water at a semiconductor electrode. A Fujishima, K HondaNature197212635268Yes
57530443044.065.0265.0TGFbeta in Cancer. Joan MassaguéCell200818662538No
57630413041.070.5570.5Cadherin cell adhesion receptors as a morphogenetic regulator. M TakeichiScience19912006419No
57730363036.087.687.6Efficient methods to compute genomic predictions. P M VanRadenJ Dairy Sci200818946147Yes
57830353035.056.7256.7Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. P SchuckBiophys J200010692345Yes
57960703035.00.00.0A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. S Reitman, S FrankelAm J Clin Pathol195713458125Yes
58030353035.073.3173.3The resurgence of platinum-based cancer chemotherapy. Lloyd KellandNat Rev Cancer200717625587No
581242423030.2525.3565.7The Protein Data Bank. H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E BourneNucleic Acids Res200010592235Yes
58230293029.0117.26117.3A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. S HakomoriJ Biochem196414135466Yes
58330293029.0102.59102.6What is value in health care? Michael E PorterN Engl J Med201021142528Yes
58460483024.0191.3595.7Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. R M Ryan, E L DeciAm Psychol200011392867Yes
58560343017.0259.08129.5GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. Rod Peakall, Peter E SmouseBioinformatics201222820204Yes
58630113011.0102.46102.5Measurement of pain. E C HuskissonLancet19744139420Yes
58730093009.0135.88135.9The short-form McGill Pain Questionnaire. Ronald MelzackPain19873670870Yes
58860173008.5142.6671.3Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. T C Chou, P TalalayAdv Enzyme Regul19846382953Yes
58990253008.3177.1459.0Significance analysis of microarrays applied to the ionizing radiation response. V G Tusher, R Tibshirani, G ChuProc Natl Acad Sci U S A200111309499Yes
59030073007.00.00.0A study of fixation for electron microscopy. G E PaladeJ Exp Med195214927794Yes
591120243006.0284.3371.1Haploview: analysis and visualization of LD and haplotype maps. J C Barrett, B Fry, J Maller, M J DalyBioinformatics200515297300Yes
59289752991.7207.3769.1TopHat: discovering splice junctions with RNA-Seq. Cole Trapnell, Lior Pachter, Steven L SalzbergBioinformatics200919289445Yes
59329872987.058.9659.0Toll-like receptors and innate immunity. R MedzhitovNat Rev Immunol200111905821No
59429872987.086.0986.1Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). Gunther EysenbachJ Med Internet Res200415471760No
59559722986.0134.7867.4Oxidants, oxidative stress and the biology of ageing. T Finkel, N J HolbrookNature200011089981No
59689532984.3169.1456.4Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Ron Edgar, Michael Domrachev, Alex E LashNucleic Acids Res200211752295Yes
59729832983.0111.12111.1KDIGO clinical practice guidelines for acute kidney injury. Arif KhwajaNephron Clin Pract201222890468No
59829822982.00.00.0Catheter replacement of the needle in percutaneous arteriography; a new technique. S I SeldingerActa radiol195313057644Yes
59959602980.0221.26110.6The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. P F Lovibond, S H LovibondBehav Res Ther19957726811Yes
60029742974.052.9352.9The gel-filtration behaviour of proteins related to their molecular weights over a wide range. P AndrewsBiochem J19655862401Yes
60129732973.068.8468.8Chemokines--chemotactic cytokines that mediate inflammation. A D LusterN Engl J Med19989459648No
60259422971.0124.9262.5Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. D B Smith, K S JohnsonGene19883047011Yes
60329662966.0529.23529.2Hallmarks of Cancer: New Dimensions. Douglas HanahanCancer Discov202235022204No
60429652965.054.854.8RNA interference. Gregory J HannonNature200212110901No
60529642964.073.5973.6Optimal two-stage designs for phase II clinical trials. R SimonControl Clin Trials19892702835Yes
60659192959.5125.1262.6Emergence of scaling in random networks. AL Barabasi, R AlbertScience199910521342Yes
607207082958.3774.69110.7limma powers differential expression analyses for RNA-sequencing and microarray studies. Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K SmythNucleic Acids Res201525605792Yes
60829582958.091.2391.2Matrix metalloproteinases and their inhibitors in connective tissue remodeling. J F WoessnerFASEB J19911850705No
60929572957.094.094.0An empirical correction for absorption anisotropy. R H BlessingActa Crystallogr A19957702794Yes
610265982955.3841.5293.5STAR: ultrafast universal RNA-seq aligner. Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R GingerasBioinformatics201323104886Yes
61188632954.3288.996.3Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. R A Deyo, D C Cherkin, M A CiolJ Clin Epidemiol19921607900Yes
61229532953.089.889.8Estimation of metabolite concentrations from localized in vivo proton NMR spectra. S W ProvencherMagn Reson Med19938139448Yes
61358982949.0185.3192.7Tissue engineering. R Langer, J P VacantiScience19938493529No
61488292943.0242.380.8Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Y Gavrieli, Y Sherman, S A Ben-SassonJ Cell Biol19921400587Yes
61529402940.066.1166.1Autophagy: process and function. Noboru MizushimaGenes Dev200718006683No
61658782939.0244.52122.3Assessment of outcome after severe brain damage. B Jennett, M BondLancet197546957Yes
617322232929.4671.0361.0Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P MesirovProc Natl Acad Sci U S A200516199517Yes
61858582929.0152.276.1Pattern recognition receptors and inflammation. Osamu Takeuchi, Shizuo AkiraCell201020303872No
61929272927.068.9268.9MapChart: software for the graphical presentation of linkage maps and QTLs. R E VoorripsJ Hered200212011185Yes
62029172917.047.2847.3A Rationale And Test For The Number Of Factors In Factor Analysis. J L HornPsychometrika196514306381Yes
62187282909.3200.9867.0The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. R C Lee, R L Feinbaum, V AmbrosCell19938252621Yes
62229052905.065.5565.5Calcium signaling. David E ClaphamCell200718083096No
62387072902.3440.43146.8Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. P J Van Soest, J B Robertson, B A LewisJ Dairy Sci19911660498No
62429022902.043.7243.7Towards a network theory of the immune system. N K JerneAnn Immunol (Paris)19744142565No
62529012901.0101.37101.4Measures of reliability in sports medicine and science. W G HopkinsSports Med200010907753Yes
62629012901.00.00.0The genetical structure of populations. S WrightAnn Eugen195124540312Yes
627116022900.5340.6185.2Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Qiong Wang, George M Garrity, James M Tiedje, James R ColeAppl Environ Microbiol200717586664Yes
62857992899.5121.4660.7Inflammation and cancer: back to Virchow? F Balkwill, A MantovaniLancet200111229684No
62986922897.30.00.0The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. R J Havel, H A Eder, J H BragdonJ Clin Invest195513252080Yes
63057912895.5161.7880.9Inositol trisphosphate, a novel second messenger in cellular signal transduction. M J Berridge, R F IrvineNature19846095092No
63128942894.068.4368.4Structure and function of telomeres. E H BlackburnNature19911708110No
63228942894.070.3870.4Phase separation of integral membrane proteins in Triton X-114 solution. C BordierJ Biol Chem19816257680Yes
63328902890.067.4467.4Modularity and community structure in networks. M E J NewmanProc Natl Acad Sci U S A200616723398Yes
63457762888.0178.1389.1The fluid mosaic model of the structure of cell membranes. S J Singer, G L NicolsonScience19724333397Yes
63528852885.059.9560.0Principles of CDK regulation. D O MorganNature19957877684No
63628842884.086.2586.2Implications of normal brain development for the pathogenesis of schizophrenia. D R WeinbergerArch Gen Psychiatry19873606332Yes
63757652882.5152.1276.1Unified segmentation. John Ashburner, Karl J FristonNeuroimage200515955494Yes
63828802880.029.1529.1Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. P MitchellNature196113771349Yes
63928792879.061.8561.9Inflammatory bowel disease. Daniel K PodolskyN Engl J Med200212167685No
64057502875.0126.5963.3Oncomirs - microRNAs with a role in cancer. Aurora Esquela-Kerscher, Frank J SlackNat Rev Cancer200616557279No
64128682868.050.4950.5A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. E A GehanBiometrika196514341275Yes
64228672867.095.7995.8Role of oxidative stress in development of complications in diabetes. J W BaynesDiabetes19912010041No
64328662866.050.850.8One-step gene disruption in yeast. R J RothsteinMethods Enzymol19836310324Yes
64428612861.00.00.0Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. W C SchneiderJ Biol Chem194521005736Yes
64528602860.052.5552.5Genome maintenance mechanisms for preventing cancer. J H HoeijmakersNature200111357144No
64628522852.00.00.0Notes on sugar determination. M SmogyiJ Biol Chem195214938350Yes
64756992849.5248.47124.2Revised methods for the Salmonella mutagenicity test. D M Maron, B N AmesMutat Res19836341825Yes
64885452848.3241.9880.7Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. G Fairbanks, T L Steck, D F WallachBiochemistry19714326772Yes
64928472847.056.3156.3Papillomaviruses and cancer: from basic studies to clinical application. Harald zur HausenNat Rev Cancer200212044010No
65028462846.061.0661.1Nuclear factor-kappaB in cancer development and progression. Michael KarinNature200616724054No
65128452845.055.8155.8A gene complex controlling segmentation in Drosophila. E B LewisNature1978103000Yes
65228452845.071.6371.6Analysis of gene diversity in subdivided populations. M NeiProc Natl Acad Sci U S A19734519626Yes
65328412841.055.6455.6Interleukin-12 and the regulation of innate resistance and adaptive immunity. Giorgio TrinchieriNat Rev Immunol200312563297No
65428402840.0105.77105.8Role of nrf2 in oxidative stress and toxicity. Qiang MaAnnu Rev Pharmacol Toxicol201323294312No
65528382838.00.00.0A study of the adrenotropic receptors. R P AhlquistAm J Physiol194818882199Yes
65628362836.093.7793.8Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. B E MurphyJ Clin Endocrinol Metab19674291524Yes
65728232823.082.7282.7Separation of leukocytes from blood and bone marrow. Introduction. A BöyumScand J Clin Lab Invest Suppl19685707208Yes
65856452822.5143.4971.7Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Glowinski, L L IversenJ Neurochem19665950056Yes
659112872821.8501.44125.4IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang MinhMol Biol Evol201525371430Yes
66028212821.053.5453.5Elastic properties of lipid bilayers: theory and possible experiments. W HelfrichZ Naturforsch C19734273690Yes
66128212821.062.8962.9Salt and drought stress signal transduction in plants. Jian-Kang ZhuAnnu Rev Plant Biol200212221975No
66228132813.085.2885.3Primate models of movement disorders of basal ganglia origin. M R DeLongTrends Neurosci19901695404No
66328122812.0121.52121.5Colorimetric assay of catalase. A K SinhaAnal Biochem19724556490Yes
66456222811.0173.7586.9Computed tomography--an increasing source of radiation exposure. David J Brenner, Eric J HallN Engl J Med200718046031No
66556172808.5112.8856.4Establishment in culture of pluripotential cells from mouse embryos. M J Evans, M H KaufmanNature19817242681Yes
66656092804.5134.6667.3Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. S Marklund, G MarklundEur J Biochem19744215654Yes
66728042804.087.8987.9Stereotaxic mapping of the monoamine pathways in the rat brain. U UngerstedtActa Physiol Scand Suppl19714109331Yes
66828022802.047.7247.7Mechanisms underlying ubiquitination. C M PickartAnnu Rev Biochem200111395416No
66984042801.3362.05120.7Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. J L Cox, J M Holden, R SagovskyBr J Psychiatry19873651732Yes
67055982799.0152.8876.4The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. J Vieira, J MessingGene19826295879Yes
67155962798.0192.6296.3A method of comparing the areas under receiver operating characteristic curves derived from the same cases. J A Hanley, B J McNeilRadiology19836878708Yes
67255942797.0186.6393.3Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. J Sedlak, R H LindsayAnal Biochem19684973948Yes
67327942794.0125.97126.0Detecting alcoholism. The CAGE questionnaire. J A EwingJAMA19846471323Yes
67455852792.5126.6863.3Caspases: enemies within. N A Thornberry, Y LazebnikScience19989721091No
67555782789.077.8338.9A method for determining the sedimentation behavior of enzymes: application to protein mixtures. R G Martin, B N AmesJ Biol Chem196113767412Yes
67655752787.5265.83132.9Stress, social support, and the buffering hypothesis. S Cohen, T A WillsPsychol Bull19853901065No
67783622787.3190.1363.4Pathogen recognition and innate immunity. Shizuo Akira, Satoshi Uematsu, Osamu TakeuchiCell200616497588No
67883552785.0205.0668.4Canonical sampling through velocity rescaling. Giovanni Bussi, Davide Donadio, Michele ParrinelloJ Chem Phys200717212484Yes
679111332783.2298.7174.7Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. P W Rigby, M Dieckmann, C Rhodes, P BergJ Mol Biol1977881736Yes
68027802780.070.2570.2The genetic legacy of the Quaternary ice ages. G HewittNature200010879524No
68127792779.065.1565.2Molecular chaperones in cellular protein folding. F U HartlNature19968637592No
68255532776.5109.8154.9Innate immune recognition. Charles A Janeway, Ruslan MedzhitovAnnu Rev Immunol200211861602No
683111002775.0337.5984.4Cancer statistics, 2010. Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth WardCA Cancer J Clin201020610543Yes
68427752775.0112.08112.1Microplastics in the marine environment. Anthony L AndradyMar Pollut Bull201121742351No
68527732773.0108.95109.0A simple technique for demonstrating centromeric heterochromatin. A T SumnerExp Cell Res19724117921Yes
68627732773.00.00.0Efficient trace-labelling of proteins with iodine. A S McFARLANENature195813566175Yes
68727712771.069.7169.7Models for the specific adhesion of cells to cells. G I BellScience1978347575No
68827632763.077.677.6Parkinson's disease: clinical features and diagnosis. J JankovicJ Neurol Neurosurg Psychiatry200818344392No
68927622762.069.6869.7Dietary pattern analysis: a new direction in nutritional epidemiology. Frank B HuCurr Opin Lipidol200211790957No
69055232761.5199.7899.9Longitudinal data analysis for discrete and continuous outcomes. S L Zeger, K Y LiangBiometrics19863719049Yes
69127602760.0116.89116.9Statistics corner: A guide to appropriate use of correlation coefficient in medical research. M M MukakaMalawi Med J201223638278Yes
69255192759.5130.4665.2Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. F W Studier, B A MoffattJ Mol Biol19863537305Yes
69327592759.065.665.6T cell exhaustion. E John WherryNat Immunol201121739672No
69455092754.5133.4866.7Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. D Hanahan, J FolkmanCell19968756718No
69555042752.0127.7263.9Autophagy in the pathogenesis of disease. Beth Levine, Guido KroemerCell200818191218No
69655022751.0151.9276.0Adherence to medication. Lars Osterberg, Terrence BlaschkeN Engl J Med200516079372No
69754972748.591.0145.5A modified uronic acid carbazole reaction. T Bitter, H M MuirAnal Biochem196213971270Yes
69827462746.00.00.0Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. L SvennerholmBiochim Biophys Acta195713436486Yes
699109842746.01398.05349.5Cancer Statistics, 2021. Rebecca L Siegel, Kimberly D Miller, Hannah E Fuchs, Ahmedin JemalCA Cancer J Clin202133433946Yes
70027452745.079.8279.8The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Claudio HetzNat Rev Mol Cell Biol201222251901No
70127432743.066.1766.2Cell death during development of the nervous system. R W OppenheimAnnu Rev Neurosci19912031577No
70227402740.059.1159.1Bone resorption by osteoclasts. S L TeitelbaumScience200010968780No
70354722736.0166.7383.4Glutathione. A Meister, M E AndersonAnnu Rev Biochem19836137189No
70427342734.070.5270.5Predictive reward signal of dopamine neurons. W SchultzJ Neurophysiol19989658025No
70527302730.082.2182.2SF-36 health survey update. J E WareSpine (Phila Pa 1976)200011124729No
70627292729.053.153.1The danger model: a renewed sense of self. Polly MatzingerScience200211951032Yes
70727262726.061.4961.5Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. S A BustinJ Mol Endocrinol200011013345No
70854442722.0107.6853.8High-efficiency transformation of mammalian cells by plasmid DNA. C Chen, H OkayamaMol Cell Biol19873670292Yes
70981602720.0239.9980.0FastTree 2--approximately maximum-likelihood trees for large alignments. Morgan N Price, Paramvir S Dehal, Adam P ArkinPLoS One201020224823Yes
71054392719.5159.1379.6Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. Jeng-Da Chai, Martin Head-GordonPhys Chem Chem Phys200818989472Yes
71154382719.0184.4692.2Extracellular vesicles: exosomes, microvesicles, and friends. Graça Raposo, Willem StoorvogelJ Cell Biol201323420871No
71227192719.0151.83151.8Hepatocellular Carcinoma. Augusto VillanuevaN Engl J Med201930970190No
71327182718.071.7271.7The magical number 4 in short-term memory: a reconsideration of mental storage capacity. N CowanBehav Brain Sci200111515286Yes
71481412713.7175.6958.6Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. C M Gorman, L F Moffat, B H HowardMol Cell Biol19826960240Yes
71527112711.062.8662.9Memory--a century of consolidation. J L McGaughScience200010634773No
71654022701.0153.6876.8The Social Readjustment Rating Scale. T H Holmes, R H RaheJ Psychosom Res19676059863Yes
71726982698.060.8360.8Cell adhesion: the molecular basis of tissue architecture and morphogenesis. B M GumbinerCell19968608588No
71853802690.0184.4592.2The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. S H Downs, N BlackJ Epidemiol Community Health19989764259Yes
71980562685.3199.4966.5MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Sudhir Kumar, Koichiro Tamura, Masatoshi NeiBrief Bioinform200415260895Yes
72080552685.0272.5290.8Effect of the damping function in dispersion corrected density functional theory. Stefan Grimme, Stephan Ehrlich, Lars GoerigkJ Comput Chem201121370243Yes
721107372684.2316.4179.1Establishing a standard definition for child overweight and obesity worldwide: international survey. T J Cole, M C Bellizzi, K M Flegal, W H DietzBMJ200010797032Yes
72226832683.060.3160.3Prostaglandins and leukotrienes: advances in eicosanoid biology. C D FunkScience200111729303No
723107312682.8227.6356.9Cluster analysis and display of genome-wide expression patterns. M B Eisen, P T Spellman, P O Brown, D BotsteinProc Natl Acad Sci U S A19989843981Yes
72426782678.058.7258.7On the number of segregating sites in genetical models without recombination. G A WattersonTheor Popul Biol19751145509Yes
72526702670.023.3923.4Satellite cell of skeletal muscle fibers. A MauroJ Biophys Biochem Cytol196113768451Yes
72626692669.051.5351.5Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Shimon SakaguchiAnnu Rev Immunol200415032588No
72726652665.064.5564.5Molecular basis of bacterial outer membrane permeability revisited. Hiroshi NikaidoMicrobiol Mol Biol Rev200314665678No
728159792663.2356.8959.5Phaser crystallographic software. Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J ReadJ Appl Crystallogr200719461840Yes
72926582658.062.1362.1Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. P CuatrecasasJ Biol Chem19705432796Yes
73053122656.0165.0282.5Accurate and simple analytic representation of the electron-gas correlation energy. J P Perdew, Y WangPhys Rev B Condens Matter199210001404Yes
73153052652.5162.8781.4Rapid isolation of high molecular weight plant DNA. M G Murray, W F ThompsonNucleic Acids Res19807433111Yes
73226492649.060.560.5Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. G P SmithScience19854001944Yes
73352902645.00.00.0Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. J D Watson, F H CrickNature195313054692Yes
73426432643.083.1583.2Social cognitive theory: an agentic perspective. A BanduraAnnu Rev Psychol200111148297Yes
73526432643.0103.25103.2Central sensitization: implications for the diagnosis and treatment of pain. Clifford J WoolfPain201120961685No
73626412641.082.1382.1What are the functional consequences of neurocognitive deficits in schizophrenia? M F GreenAm J Psychiatry19968610818No
73726412641.059.5959.6Vascular endothelial growth factor: basic science and clinical progress. Napoleone FerraraEndocr Rev200415294883No
73852722636.0209.7104.8A feature-integration theory of attention. A M Treisman, G GeladeCogn Psychol19807351125Yes
73926362636.081.4881.5The free-energy principle: a unified brain theory? Karl FristonNat Rev Neurosci201020068583No
74052422621.0142.4871.2Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. L A Greene, A S TischlerProc Natl Acad Sci U S A19761065897Yes
74126202620.0106.63106.6The biology of oxygen radicals. I FridovichScience1978210504Yes
74226192619.065.1765.2The nerve growth factor 35 years later. R Levi-MontalciniScience19873306916No
74352262613.0117.3758.7Signal transduction by receptors with tyrosine kinase activity. A Ullrich, J SchlessingerCell19902158859No
74426132613.0106.2106.2Qualitative research. Introducing focus groups. J KitzingerBMJ19957633241Yes
74526132613.075.0975.1Stress, adaptation, and disease. Allostasis and allostatic load. B S McEwenAnn N Y Acad Sci19989629234No
74652262613.0107.3353.7MicroRNAs: small RNAs with a big role in gene regulation. Lin He, Gregory J HannonNat Rev Genet200415211354No
74726122612.0121.26121.3The membrane actions of anesthetics and tranquilizers. P SeemanPharmacol Rev19724565956No
74852222611.0101.7950.9Untangling the ErbB signalling network. Y Yarden, M X SliwkowskiNat Rev Mol Cell Biol200111252954No
74952222611.00.00.0Some quantitative uses of drug antagonists. O Arunlakshana, H O SchildBr J Pharmacol Chemother195913651579Yes
75052152607.5180.7490.4A simple, rapid, and sensitive DNA assay procedure. C Labarca, K PaigenAnal Biochem19806158890Yes
75126032603.080.080.0A rating instrument for anxiety disorders. W W ZungPsychosomatics19715172928Yes
75225962596.072.5672.6Two-sided confidence intervals for the single proportion: comparison of seven methods. R G NewcombeStat Med19989595616Yes
75325922592.050.7350.7Tumour-educated macrophages promote tumour progression and metastasis. Jeffrey W PollardNat Rev Cancer200414708027No
75425902590.073.5173.5Formation and Structure of Self-Assembled Monolayers. Abraham UlmanChem Rev199611848802Yes
75525892589.055.4155.4G1 phase progression: cycling on cue. C J SherrCell19947954821No
75625882588.089.0189.0A computational approach to edge detection. J CannyIEEE Trans Pattern Anal Mach Intell198621869365Yes
75725842584.053.8653.9Evolving concepts of rheumatoid arthritis. Gary S FiresteinNature200312748655No
75825832583.056.6256.6Epigenetics in cancer. Manel EstellerN Engl J Med200818337604No
75925812581.080.7280.7Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. B SamuelssonScience19836301011Yes
76025812581.062.2462.2Cancer nanotechnology: opportunities and challenges. Mauro FerrariNat Rev Cancer200515738981No
76151572578.5249.91125.0Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. J Silness, H LoeActa Odontol Scand196414158464Yes
76225782578.073.6273.6Delayed neuronal death in the gerbil hippocampus following ischemia. T KirinoBrain Res19827093691Yes
76351562578.0160.280.1The L-arginine-nitric oxide pathway. S Moncada, A HiggsN Engl J Med19937504210No
76451552577.5167.4783.7The neural basis of drug craving: an incentive-sensitization theory of addiction. T E Robinson, K C BerridgeBrain Res Brain Res Rev19938401595No
76551492574.573.3236.7A general method applicable to the search for similarities in the amino acid sequence of two proteins. S B Needleman, C D WunschJ Mol Biol19705420325Yes
76625702570.071.6871.7Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. P CorreaCancer Res19921458460No
76725692569.061.9762.0Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. E C ButcherCell19911760836No
76825692569.00.00.0The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. M L AnsonJ Gen Physiol193819873094Yes
76925672567.071.1271.1Physiology and neurobiology of stress and adaptation: central role of the brain. Bruce S McEwenPhysiol Rev200717615391No
77051322566.0126.6163.3Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Klaus Apel, Heribert HirtAnnu Rev Plant Biol200415377225No
77125642564.068.6568.7Dominant forces in protein folding. K A DillBiochemistry19902207096No
77225632563.036.0636.1The catecholamine hypothesis of affective disorders: a review of supporting evidence. J J SchildkrautAm J Psychiatry19655319766No
77325612561.0129.21129.2Conservation of resources. A new attempt at conceptualizing stress. S E HobfollAm Psychol19892648906No
77425612561.052.2452.2Telomere measurement by quantitative PCR. Richard M CawthonNucleic Acids Res200212000852Yes
77525612561.097.4597.5The biology and function of fibroblasts in cancer. Raghu KalluriNat Rev Cancer201627550820No
77625542554.00.00.0The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. R R PorterBiochem J195914434282Yes
77725472547.062.3462.3A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Pascal FriesTrends Cogn Sci200516150631No
77825462546.00.00.0Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. O SmithiesBiochem J195513276348Yes
77925462546.055.1455.1Angiogenesis in life, disease and medicine. Peter CarmelietNature200516355210No
78050672533.5277.04138.5A diagnostic interview: the schedule for affective disorders and schizophrenia. J Endicott, R L SpitzerArch Gen Psychiatry1978678037Yes
78125332533.050.8750.9Universal control mechanism regulating onset of M-phase. P NurseNature19902138713No
78225282528.066.6866.7Evaluating the quality of medical care. A DonabedianMilbank Mem Fund Q19665338568No
78325272527.028.1828.2The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. S BoydenJ Exp Med196213872176Yes
78475522517.3197.6365.9Regularization Paths for Generalized Linear Models via Coordinate Descent. Jerome Friedman, Trevor Hastie, Rob TibshiraniJ Stat Softw201020808728Yes
78525152515.077.2477.2Secretory products of macrophages. C F NathanJ Clin Invest19873543052No
78625082508.073.8373.8Perceived exertion as an indicator of somatic stress. G BorgScand J Rehabil Med19705523831Yes
78750152507.5220.56110.3Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. N S Jacobson, P TruaxJ Consult Clin Psychol19912002127Yes
78850142507.0116.0658.0Myeloid-derived suppressor cells as regulators of the immune system. Dmitry I Gabrilovich, Srinivas NagarajNat Rev Immunol200919197294No
78975112503.7198.0766.0Immunity, inflammation, and cancer. Sergei I Grivennikov, Florian R Greten, Michael KarinCell201020303878No
79025032503.077.1577.2The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. B L FredricksonAm Psychol200111315248Yes
79175092503.0203.5567.9Quantum mechanical continuum solvation models. Jacopo Tomasi, Benedetta Mennucci, Roberto CammiChem Rev200516092826Yes
792100092502.2404.04101.0Cancer statistics, 2014. Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin JemalCA Cancer J Clin201424399786Yes
79349942497.0156.3378.2Microenvironmental regulation of tumor progression and metastasis. Daniela F Quail, Johanna A JoyceNat Med201324202395No
79424962496.044.8744.9Wnt signaling and cancer. P PolakisGenes Dev200010921899No
79549882494.099.9950.0Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. D Bonnet, J E DickNat Med19979212098Yes
79674812493.7186.8662.3RNA-Seq: a revolutionary tool for transcriptomics. Zhong Wang, Mark Gerstein, Michael SnyderNat Rev Genet200919015660No
79749842492.0181.890.9Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. P J Fraker, J C SpeckBiochem Biophys Res Commun1978637870Yes
79849732486.5128.8364.4UniFrac: a new phylogenetic method for comparing microbial communities. Catherine Lozupone, Rob KnightAppl Environ Microbiol200516332807Yes
79949702485.0141.4970.7Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. J V Durnin, J WomersleyBr J Nutr19744843734Yes
80024842484.061.961.9Immunological and inflammatory functions of the interleukin-1 family. Charles A DinarelloAnnu Rev Immunol200919302047No
80149632481.5119.5859.8Calculation of protein extinction coefficients from amino acid sequence data. S C Gill, P H von HippelAnal Biochem19892610349Yes
80249592479.5147.2173.6SPSS and SAS procedures for estimating indirect effects in simple mediation models. Kristopher J Preacher, Andrew F HayesBehav Res Methods Instrum Comput200415641418Yes
80374382479.3192.364.1Cortical surface-based analysis. I. Segmentation and surface reconstruction. A M Dale, B Fischl, M I SerenoNeuroimage19999931268Yes
80449552477.596.2948.1CDK inhibitors: positive and negative regulators of G1-phase progression. C J Sherr, J M RobertsGenes Dev199910385618No
80524722472.0112.1112.1Oxygen-dependent microbial killing by phagocytes (first of two parts). B M BabiorN Engl J Med197824176Yes
80649372468.5122.2461.1A global optimisation method for robust affine registration of brain images. M Jenkinson, S SmithMed Image Anal200111516708Yes
80724642464.092.4292.4Missing data analysis: making it work in the real world. John W GrahamAnnu Rev Psychol200918652544No
80824602460.081.5281.5Gctf: Real-time CTF determination and correction. Kai ZhangJ Struct Biol201626592709Yes
80924512451.00.00.0Transduction of linked genetic characters of the host by bacteriophage P1. E S LennoxVirology195513267987Yes
81024472447.0121.31121.3The antibiotic resistance crisis: part 1: causes and threats. C Lee VentolaP T201525859123Yes
81148832441.5140.970.5Nonparametric statistical testing of EEG- and MEG-data. Eric Maris, Robert OostenveldJ Neurosci Methods200717517438Yes
81224412441.061.5261.5Inferring the historical patterns of biological evolution. M PagelNature199910553904Yes
81324402440.047.3147.3Getting started with yeast. F ShermanMethods Enzymol19912005794Yes
81424402440.065.5965.6Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. H G GratznerScience19827123245Yes
81573172439.0208.1669.4Bacterial biofilms: a common cause of persistent infections. J W Costerton, P S Stewart, E P GreenbergScience199910334980No
81624372437.054.2454.2Social controls on cell survival and cell death. M C RaffNature19921557121No
81748712435.5108.2254.1Signal integration in the endoplasmic reticulum unfolded protein response. David Ron, Peter WalterNat Rev Mol Cell Biol200717565364No
81897382434.5253.9863.5GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. Berk Hess, Carsten Kutzner, David van der Spoel, Erik LindahlJ Chem Theory Comput200826620784Yes
81924332433.077.8977.9Plant products as antimicrobial agents. M M CowanClin Microbiol Rev199910515903No
82024322432.057.8957.9Causes and consequences of microRNA dysregulation in cancer. Carlo M CroceNat Rev Genet200919763153No
82148632431.5103.4551.7Judgment under Uncertainty: Heuristics and Biases. A Tversky, D KahnemanScience197417835457Yes
82248622431.0129.564.8Alzheimer's disease: the amyloid cascade hypothesis. J A Hardy, G A HigginsScience19921566067No
82324292429.0109.84109.8Structural Model Evaluation and Modification: An Interval Estimation Approach. J H SteigerMultivariate Behav Res199026794479Yes
82448542427.0120.8360.4The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Karen Bedard, Karl-Heinz KrausePhysiol Rev200717237347No
82524262426.053.1453.1Rab GTPases as coordinators of vesicle traffic. Harald StenmarkNat Rev Mol Cell Biol200919603039No
82624242424.046.1846.2Mechanisms of type-I- and type-II-interferon-mediated signalling. Leonidas C PlataniasNat Rev Immunol200515864272No
82724202420.00.00.0The information capacity of the human motor system in controlling the amplitude of movement. P M FittsJ Exp Psychol195413174710Yes
82824132413.082.082.0Doxil®--the first FDA-approved nano-drug: lessons learned. Yechezkel BarenholzJ Control Release201222484195No
82924092409.052.5652.6Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. T HunterCell19957834742No
83048152407.568.3134.2Periodontal Disease In Pregnancy. I. Prevalence And Severity. H Loe, J SilnessActa Odontol Scand196314121956Yes
83124052405.050.5650.6Cisplatin: mode of cytotoxic action and molecular basis of resistance. Zahid H SiddikOncogene200314576837No
83248082404.092.8846.4The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Igor Vivanco, Charles L SawyersNat Rev Cancer200212094235No
83324032403.052.652.6The distribution of secondary growths in cancer of the breast. 1889. S PagetCancer Metastasis Rev19892673568No
83448032401.5156.5578.3Random-effects models for longitudinal data. N M Laird, J H WareBiometrics19827168798Yes
83524012401.053.7853.8The inflammatory reflex. Kevin J TraceyNature200212490958No
83623982398.043.7643.8Java Treeview--extensible visualization of microarray data. Alok J SaldanhaBioinformatics200415180930Yes
83723982398.075.7675.8Epidemiology of viral hepatitis and hepatocellular carcinoma. Hashem B El-SeragGastroenterology201222537432No
83847952397.594.1547.1Lipid rafts and signal transduction. K Simons, D ToomreNat Rev Mol Cell Biol200011413487No
83923962396.057.6157.6An index to quantify an individual's scientific research output. J E HirschProc Natl Acad Sci U S A200516275915Yes
84023952395.079.779.7Working memory. A BaddeleyScience19921736359No
84147842392.0142.6371.3Neural mechanisms of selective visual attention. R Desimone, J DuncanAnnu Rev Neurosci19957605061No
84247822391.0141.270.6Missing data: our view of the state of the art. Joseph L Schafer, John W GrahamPsychol Methods200212090408Yes
84323892389.060.3260.3Network pharmacology: the next paradigm in drug discovery. Andrew L HopkinsNat Chem Biol200818936753No
84495452386.2227.3156.8Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. C A Lipinski, F Lombardo, B W Dominy, P J FeeneyAdv Drug Deliv Rev200111259830No
84547662383.0120.4560.2Management of hepatocellular carcinoma. Jordi Bruix, Morris ShermanHepatology200516250051No
84623832383.00.00.0Isolation by Distance. S WrightGenetics194317247074Yes
84723792379.043.4943.5Targeting RAS signalling pathways in cancer therapy. Julian DownwardNat Rev Cancer200312509763No
84823762376.054.454.4A decade of molecular biology of retinoic acid receptors. P ChambonFASEB J19968801176No
84923752375.049.3949.4Molecular physiology of P2X receptors. R Alan NorthPhysiol Rev200212270951No
85047402370.0133.0966.5The number of people with glaucoma worldwide in 2010 and 2020. H A Quigley, A T BromanBr J Ophthalmol200616488940Yes
85147392369.5128.1264.1Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. G Kresse, J HafnerPhys Rev B Condens Matter199410010505Yes
85247332366.5161.8380.9The biofilm matrix. Hans-Curt Flemming, Jost WingenderNat Rev Microbiol201020676145No
85323652365.080.4580.5A rapid radiochemical method for the determination of choline acetyltransferase. F FonnumJ Neurochem19751113118Yes
85423652365.051.3351.3A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Douglas C WallaceAnnu Rev Genet200516285865No
85523642364.066.9466.9Scaffolds in tissue engineering bone and cartilage. D W HutmacherBiomaterials200011071603Yes
85623642364.00.00.0Muscle structure and theories of contraction. A F HuxleyProg Biophys Biophys Chem195713485191Yes
85723622362.093.6293.6The Michigan alcoholism screening test: the quest for a new diagnostic instrument. M L SelzerAm J Psychiatry19715565851Yes
85823602360.092.1692.2Effective physician-patient communication and health outcomes: a review. M A StewartCMAJ19957728691Yes
85970772359.0203.3567.8GSVA: gene set variation analysis for microarray and RNA-seq data. Sonja Hänzelmann, Robert Castelo, Justin GuinneyBMC Bioinformatics201323323831Yes
86047152357.5205.31102.7The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. H P Misra, I FridovichJ Biol Chem19724623845Yes
86123562356.061.9862.0A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. P ChomczynskiBiotechniques19937692896Yes
86270672355.7154.251.4The biology of VEGF and its receptors. Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouterNat Med200312778165No
86347112355.5113.1256.6A scaling normalization method for differential expression analysis of RNA-seq data. Mark D Robinson, Alicia OshlackGenome Biol201020196867Yes
86447042352.097.5548.8New functions for the matrix metalloproteinases in cancer progression. Mikala Egeblad, Zena WerbNat Rev Cancer200211990853No
86547022351.0103.1751.6Death receptors: signaling and modulation. A Ashkenazi, V M DixitScience19989721089No
86623502350.096.8596.8The validity and practicality of sun-reactive skin types I through VI. T B FitzpatrickArch Dermatol19883377516Yes
86723502350.0127.37127.4Determination and quantification of content validity. M R LynnNurs Res19863640358Yes
86823492349.051.551.5Mitochondrial diseases in man and mouse. D C WallaceScience199910066162No
86946932346.5127.4863.7Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Michael D Fox, Marcus E RaichleNat Rev Neurosci200717704812No
87070332344.369.9223.3On The Nature Of Allosteric Transitions: A Plausible Model. J Monod, J Wyman, J P ChangeuxJ Mol Biol196514343300Yes
87123432343.071.0871.1A two process model of sleep regulation. A A BorbélyHum Neurobiol19827185792Yes
87223432343.062.7562.8Intestinal mucosal barrier function in health and disease. Jerrold R TurnerNat Rev Immunol200919855405No
87346762338.0118.6359.3Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Marie-Christine Daniel, Didier AstrucChem Rev200414719978No
87423382338.059.1759.2A theory of cortical responses. Karl FristonPhilos Trans R Soc Lond B Biol Sci200515937014No
87523372337.052.052.0The structure and regulation of protein phosphatases. P CohenAnnu Rev Biochem19892549856No
87646722336.0103.6251.8Screening lambdagt recombinant clones by hybridization to single plaques in situ. W D Benton, R W DavisScience1977322279Yes
87746642332.0103.0251.5AKT/PKB signaling: navigating downstream. Brendan D Manning, Lewis C CantleyCell200717604717No
87846632331.5123.1761.6Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. C W Elston, I O EllisHistopathology19911757079Yes
87946622331.0117.2358.6Acute-phase proteins and other systemic responses to inflammation. C Gabay, I KushnerN Engl J Med19999971870No
88023302330.0104.07104.1Deep learning in neural networks: an overview. Jürgen SchmidhuberNeural Netw201525462637No
88123272327.084.2984.3Calmodulin plays a pivotal role in cellular regulation. W Y CheungScience19806243188No
88223242324.066.2166.2Interleukin-1 and interleukin-1 antagonism. C A DinarelloBlood19911826616No
88346452322.587.3343.7A novel genetic system to detect protein-protein interactions. S Fields, O SongNature19892547163Yes
88423222322.048.9949.0NOX enzymes and the biology of reactive oxygen. J David LambethNat Rev Immunol200415039755No
88546382319.0130.2265.1Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. R A Laskey, A D MillsEur J Biochem19751175627Yes
88623192319.055.3955.4Ischemic cell death in brain neurons. P LiptonPhysiol Rev199910508238No
88746382319.0113.3356.7Nonparametric permutation tests for functional neuroimaging: a primer with examples. Thomas E Nichols, Andrew P HolmesHum Brain Mapp200211747097Yes
88892752318.82060.1515.0Cancer statistics, 2022. Rebecca L Siegel, Kimberly D Miller, Hannah E Fuchs, Ahmedin JemalCA Cancer J Clin202235020204Yes
88923182318.057.2557.2A model for receptor-regulated calcium entry. J W PutneyCell Calcium19862420465No
89046362318.0170.385.2Self-rated health and mortality: a review of twenty-seven community studies. E L Idler, Y BenyaminiJ Health Soc Behav19979097506No
89123162316.041.9441.9Stereochemistry of cooperative effects in haemoglobin. M F PerutzNature19705528785Yes
89223142314.056.9557.0Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. Jane GlazebrookAnnu Rev Phytopathol200516078883No
89323132313.078.6978.7Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. F F JöbsisScience1977929199Yes
89423132313.049.9349.9Nitric oxide and the immune response. C BogdanNat Immunol200111577346No
89523112311.059.6359.6MYC on the path to cancer. Chi V DangCell201222464321No
89646202310.0123.9462.0Application of phylogenetic networks in evolutionary studies. Daniel H Huson, David BryantMol Biol Evol200616221896Yes
89746162308.089.7444.9Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Yigong Shi, Joan MassaguéCell200312809600No
89823072307.053.5453.5Specification of cerebral cortical areas. P RakicScience19883291116No
89923052305.065.7365.7Inositol phospholipids and cell surface receptor function. R H MichellBiochim Biophys Acta1975164246No
90023052305.077.0777.1Simplified calculation of body-surface area. R D MostellerN Engl J Med19873657876Yes
90123042304.027.2527.2Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. T HiguchiJ Pharm Sci196314088963Yes
90246062303.073.7836.9On the size of the active site in proteases. I. Papain. I Schechter, A BergerBiochem Biophys Res Commun19676035483Yes
90323012301.00.00.0Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. G BertaniJ Bacteriol195114888646Yes
90446012300.572.0336.0High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. M N Berry, D S FriendJ Cell Biol19694900611Yes
90592012300.2200.5450.1Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. A Krogh, B Larsson, G von Heijne, E L SonnhammerJ Mol Biol200111152613Yes
90623002300.055.7655.8The anatomy and taxonomy of protein structure. J S RichardsonAdv Protein Chem19817020376No
90722992299.074.8474.8Qualitative research: standards, challenges, and guidelines. K MalterudLancet200111513933Yes
90845942297.0168.2984.1The attention system of the human brain. M I Posner, S E PetersenAnnu Rev Neurosci19902183676No
90922972297.056.9957.0Bcl-2 and the regulation of programmed cell death. J C ReedJ Cell Biol19948294493No
91022952295.071.9672.0Human error: models and management. J ReasonBMJ200010720363Yes
91122952295.064.7564.8TGFβ signalling in context. Joan MassaguéNat Rev Mol Cell Biol201222992590No
91245852292.5115.4457.7A receptor-mediated pathway for cholesterol homeostasis. M S Brown, J L GoldsteinScience19863513311No
91345842292.086.6243.3The interpretation of protein structures: estimation of static accessibility. B Lee, F M RichardsJ Mol Biol19715551392Yes
91422922292.054.8554.9Lead- and drug-like compounds: the rule-of-five revolution. Christopher A LipinskiDrug Discov Today Technol200424981612Yes
91522912291.071.571.5Reactive oxygen species and the central nervous system. B HalliwellJ Neurochem19921402908No
91645822291.0107.1553.6Protein misfolding, functional amyloid, and human disease. Fabrizio Chiti, Christopher M DobsonAnnu Rev Biochem200616756495No
91722882288.055.8655.9P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation. Berk HessJ Chem Theory Comput200826619985Yes
91822872287.060.4260.4The importance of selenium to human health. M P RaymanLancet200010963212No
91922862286.074.4674.5Eye movements in reading and information processing: 20 years of research. K RaynerPsychol Bull19989849112No
92022822282.045.2145.2SV40-transformed simian cells support the replication of early SV40 mutants. Y GluzmanCell19816260373Yes
92122772277.058.3858.4The blood-brain barrier in health and chronic neurodegenerative disorders. Berislav V ZlokovicNeuron200818215617No
92222762276.076.2676.3Glutamate, nitric oxide and cell-cell signalling in the nervous system. J GarthwaiteTrends Neurosci19911708538No
92322752275.042.6642.7Histone acetylation in chromatin structure and transcription. M GrunsteinNature19979311776No
92422752275.057.957.9Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. R D Pascual-MarquiMethods Find Exp Clin Pharmacol200212575463No
92522742274.055.4655.5Animal mitochondrial genomes. J L BooreNucleic Acids Res199910101183No
92622742274.078.1278.1Large-scale brain networks and psychopathology: a unifying triple network model. Vinod MenonTrends Cogn Sci201121908230No
92745472273.5122.6261.3A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Y Matsumura, H MaedaCancer Res19862946403Yes
92845392269.595.2347.6Mass spectrometry-based proteomics. Ruedi Aebersold, Matthias MannNature200312634793No
92922692269.072.1172.1Spinal and supraspinal factors in human muscle fatigue. S C GandeviaPhysiol Rev200111581501No
93022652265.0116.8116.8Electroimmuno assay. C B LaurellScand J Clin Lab Invest Suppl19724114358Yes
93122642264.065.6365.6Hazards of heavy metal contamination. Lars JärupBr Med Bull200314757716No
93222612261.048.8848.9Chemokines and leukocyte traffic. M BaggioliniNature19989560152No
93322612261.00.00.0[Rapid physiological coagulation method in determination of fibrinogen]. A ClaussActa Haematol195713434757Yes
93422602260.044.4344.4The molecular biology of memory storage: a dialogue between genes and synapses. E R KandelScience200111691980No
93522602260.050.9751.0Application of a microtechnique to viral serological investigations. J L SeverJ Immunol196213910995Yes
93622602260.060.0560.0Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Claudiu T SupuranNat Rev Drug Discov200818167490No
93722582258.059.3159.3Epidemiology of insomnia: what we know and what we still need to learn. Maurice M OhayonSleep Med Rev200212531146Yes
93822562256.068.7568.8Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. R A DeFronzoDiabetes19883289989No
93922562256.0108.3108.3Abiotic Stress Signaling and Responses in Plants. Jian-Kang ZhuCell201627716505No
94022522252.065.4665.5Social determinants of health inequalities. Michael MarmotLancet200515781105Yes
94122512251.058.3458.3Working memory: looking back and looking forward. Alan BaddeleyNat Rev Neurosci200314523382No
94222492249.066.9166.9PsychoPy--Psychophysics software in Python. Jonathan W PeirceJ Neurosci Methods200717254636Yes
94322472247.084.0184.0Specific impairments of planning. T ShallicePhilos Trans R Soc Lond B Biol Sci19826125971Yes
94444932246.5102.7651.4A simple and very efficient method for generating cDNA libraries. U Gubler, B J HoffmanGene19836198242Yes
94544902245.0100.4550.2Brown adipose tissue: function and physiological significance. Barbara Cannon, Jan NedergaardPhysiol Rev200414715917No
94622442244.053.253.2Protein kinase C and lipid signaling for sustained cellular responses. Y NishizukaFASEB J19957737456No
94722442244.056.0756.1RGD and other recognition sequences for integrins. E RuoslahtiAnnu Rev Cell Dev Biol19968970741No
94822422242.0142.25142.2Presidential Address-1976. Social support as a moderator of life stress. S CobbPsychosom Med1976981490Yes
94922412241.0104.97105.0Metazoan MicroRNAs. David P BartelCell201829570994No
95044782239.0108.1154.1Regulation of the mevalonate pathway. J L Goldstein, M S BrownNature19901967820No
95122382238.061.2361.2Molecular diversity of glutamate receptors and implications for brain function. S NakanishiScience19921329206No
95222372237.054.954.9Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J Kyhse-AndersenJ Biochem Biophys Methods19846530509Yes
95322362236.0109.76109.8Mechanisms of action of transmitters and other substances on smooth muscle. T B BoltonPhysiol Rev197937533No
95422352235.093.6893.7What's in a name? Qualitative description revisited. Margarete SandelowskiRes Nurs Health201020014004Yes
95544692234.5127.6763.8Distributed hierarchical processing in the primate cerebral cortex. D J Felleman, D C Van EssenCereb Cortex19911822724No
95644662233.088.2144.1The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J A Spudich, S WattJ Biol Chem19714254541Yes
95722332233.068.6868.7Biodiesel from microalgae. Yusuf ChistiBiotechnol Adv200717350212No
95844632231.587.9444.0Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. T V Bliss, T LomoJ Physiol19734727084Yes
95922312231.077.3677.4Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. B N AmesScience19836351251No
96022312231.070.1470.1Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. W A CraigClin Infect Dis19989455502No
96144612230.539.419.7A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. J E TILL, E A McCULLOCHRadiat Res196113776896Yes
96244582229.0128.7364.4Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. C J Murray, A D LopezLancet19979167458Yes
96344582229.0114.8857.4ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. B Ravel, M NewvilleJ Synchrotron Radiat200515968136Yes
96422262226.041.6741.7Shelterin: the protein complex that shapes and safeguards human telomeres. Titia de LangeGenes Dev200516166375No
965178032225.4560.7470.1The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C SiebertN Engl J Med19938366922Yes
96622252225.049.1149.1The regulation of AP-1 activity by mitogen-activated protein kinases. M KarinJ Biol Chem19957622446No
96722252225.057.357.3Pancreatic cancer. Manuel HidalgoN Engl J Med201020427809No
96844472223.598.0849.0Organization and expression of eucaryotic split genes coding for proteins. R Breathnach, P ChambonAnnu Rev Biochem19816791577No
969200062222.9927.12103.0Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie BrayInt J Cancer201525220842Yes
97022222222.052.5852.6Mechanisms and genes of cellular suicide. H StellerScience19957878463No
97144342217.0112.9756.5Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. M Matsuda, R A DeFronzoDiabetes Care199910480510Yes
97222132213.048.8648.9Intracellular aspects of the process of protein synthesis. G PaladeScience19751096303No
97322132213.089.8189.8Role of Streptococcus mutans in human dental decay. W J LoescheMicrobiol Rev19863540569No
97422102210.087.3987.4Approximate entropy as a measure of system complexity. S M PincusProc Natl Acad Sci U S A199111607165Yes
97588352208.8178.944.7WebLogo: a sequence logo generator. Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E BrennerGenome Res200415173120Yes
97644172208.599.1549.6The Bcl-2 protein family: arbiters of cell survival. J M Adams, S CoryScience19989735050No
97722072207.065.7865.8Diagnosis of Alzheimer's disease. Z S KhachaturianArch Neurol19852864910Yes
97822072207.0148.56148.6Obesity: global epidemiology and pathogenesis. Matthias BlüherNat Rev Endocrinol201930814686No
97922052205.083.7283.7Role of endothelium in responses of vascular smooth muscle. R F FurchgottCirc Res19836313250No
98022022202.059.5359.5Biofilms: microbial life on surfaces. Rodney M DonlanEmerg Infect Dis200212194761No
98122012201.061.6361.6Hybrid porous solids: past, present, future. Gérard FéreyChem Soc Rev200818197340Yes
98266002200.0254.9185.0Glucose clamp technique: a method for quantifying insulin secretion and resistance. R A DeFronzo, J D Tobin, R AndresAm J Physiol1979382871Yes
98321982198.055.055.0Removal of fatty acids from serum albumin by charcoal treatment. R F ChenJ Biol Chem19676016603Yes
98421972197.068.1168.1Prooxidant states and tumor promotion. P A CeruttiScience19852981433No
98543942197.095.6647.8Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. F Sallusto, A LanzavecchiaJ Exp Med19948145033Yes
98643932196.5105.7752.9Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Michael T Lin, M Flint BealNature200617051205No
98721962196.071.5371.5Keratoconus. Y S RabinowitzSurv Ophthalmol19989493273No
98821922192.078.9879.0Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. H W SteinbuschNeuroscience19817017455Yes
98921922192.048.6148.6Chemokines. B J RollinsBlood19979242519No
99021922192.061.6261.6Infrared spectroscopy of proteins. Andreas BarthBiochim Biophys Acta200717692815No
99121902190.046.746.7Complement. First of two parts. M J WalportN Engl J Med200111287977No
99265702190.0194.6264.9The brain's default network: anatomy, function, and relevance to disease. Randy L Buckner, Jessica R Andrews-Hanna, Daniel L SchacterAnn N Y Acad Sci200818400922No
99321872187.053.0153.0Breast cancer and hormone-replacement therapy in the Million Women Study. Valerie BeralLancet200312927427Yes
99487482187.0456.09114.0fastp: an ultra-fast all-in-one FASTQ preprocessor. Shifu Chen, Yanqing Zhou, Yaru Chen, Jia GuBioinformatics201830423086Yes
99521842184.053.7653.8Using circular dichroism spectra to estimate protein secondary structure. Norma J GreenfieldNat Protoc200617406547Yes
99687352183.8209.952.5Matrix elasticity directs stem cell lineage specification. Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E DischerCell200616923388Yes
99765492183.0181.2560.4Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. F E Harrell, K L Lee, D B MarkStat Med19968668867No
99843602180.076.0138.0Variations in pattern of pubertal changes in girls. W A Marshall, J M TannerArch Dis Child19695785179Yes
99943592179.50.00.0Loss of recent memory after bilateral hippocampal lesions. W B Scoville, B MilnerJ Neurol Neurosurg Psychiatry195713406589Yes
100021792179.054.4354.4The extracellular matrix: not just pretty fibrils. Richard O HynesScience200919965464No
100121772177.090.6290.6A systematic method for clinical description and classification of personality variants. A proposal. C R CloningerArch Gen Psychiatry19873579504Yes
100221752175.066.1166.1Fetal origins of coronary heart disease. D J BarkerBMJ19957613432No
100365242174.7203.4367.8Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. R L Spitzer, K Kroenke, J B WilliamsJAMA199910568646Yes
100421722172.060.460.4Superoxide radical and superoxide dismutases. I FridovichAnnu Rev Biochem19957574505No
100521722172.058.6358.6The episodic buffer: a new component of working memory? A BaddeleyTrends Cogn Sci200011058819Yes
100643432171.5103.2551.6Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Hashem B El-Serag, K Lenhard RudolphGastroenterology200717570226No
100721712171.048.3148.3A clearer vision for in vivo imaging. R WeisslederNat Biotechnol200111283581No
100821692169.00.00.0Analysis of tissue and arterial blood temperatures in the resting human forearm. H H PennesJ Appl Physiol194818887578Yes
100921692169.062.4662.5Hypoxia-inducible factors in physiology and medicine. Gregg L SemenzaCell201222304911No
101043372168.5147.2573.6Shifting the genomic gold standard for the prokaryotic species definition. Michael Richter, Ramon Rosselló-MóraProc Natl Acad Sci U S A200919855009Yes
101121652165.056.4456.4The molecular pathology of Alzheimer's disease. D J SelkoeNeuron19911673054No
101221642164.071.5471.5A classification of glycosyl hydrolases based on amino acid sequence similarities. B HenrissatBiochem J19911747104Yes
101343252162.5148.674.3Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. R B Devereux, N ReichekCirculation1977138494Yes
101421602160.055.4555.5The physiology of glucagon-like peptide 1. Jens Juul HolstPhysiol Rev200717928588No
101521592159.041.8941.9Protein modules and signalling networks. T PawsonNature19957531822No
101621592159.055.0655.1Descending control of pain. Mark J MillanProg Neurobiol200212034378No
101721552155.049.0349.0Pathways towards and away from Alzheimer's disease. Mark P MattsonNature200415295589No
101821522152.031.1931.2Sedimentation Studies Of The Size And Shape Of Dna. F W StudierJ Mol Biol196514290352Yes
101986002150.0184.5746.1MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi MiyataNucleic Acids Res200212136088Yes
102021472147.045.7945.8Theta oscillations in the hippocampus. György BuzsákiNeuron200211832222No
102121472147.069.2969.3Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. Peter C AustinPharm Stat201120925139Yes
102264382146.0185.8561.9Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. C E Murry, R B Jennings, K A ReimerCirculation19863769170Yes
102342922146.0181.7790.9The Health Belief Model: a decade later. N K Janz, M H BeckerHealth Educ Q19846392204No
102421432143.039.9439.9NK cell recognition. Lewis L LanierAnnu Rev Immunol200515771571No
102542822141.0100.4650.2Assembly of asparagine-linked oligosaccharides. R Kornfeld, S KornfeldAnnu Rev Biochem19853896128No
102621412141.049.4549.5Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. G TrinchieriAnnu Rev Immunol19957612223No
102721402140.0115.48115.5The assessment of clinical skills/competence/performance. G E MillerAcad Med19902400509Yes
102821392139.064.9865.0Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Leonardo PantoniLancet Neurol201020610345No
102942762138.073.4336.7A Simplified Lead Citrate Stain For Use In Electron Microscopy. J H Venable, R CoggeshallJ Cell Biol196514287192Yes
103021382138.00.00.0A new specific color reaction of hexuronic acids. Z DischeJ Biol Chem194720281638Yes
103142732136.5103.651.8Measuring the thickness of the human cerebral cortex from magnetic resonance images. B Fischl, A M DaleProc Natl Acad Sci U S A200010984517Yes
103221362136.048.5148.5Comparison of the predicted and observed secondary structure of T4 phage lysozyme. B W MatthewsBiochim Biophys Acta19751180967Yes
103364082136.0131.3843.8Immunochemical quantitation of antigens by single radial immunodiffusion. G Mancini, A O Carbonara, J F HeremansImmunochemistry19654956917Yes
103442722136.0106.9653.5Function and activation of NF-kappa B in the immune system. P A Baeuerle, T HenkelAnnu Rev Immunol19948011280No
1035128102135.0286.247.7NMRPipe: a multidimensional spectral processing system based on UNIX pipes. F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A BaxJ Biomol NMR19958520220Yes
103621352135.051.2151.2Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Edward V LoftusGastroenterology200415168363Yes
103721322132.092.3992.4The Children's Depression, Inventory (CDI). M KovacsPsychopharmacol Bull19854089116Yes
103842632131.5122.9561.5Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. J S Beckman, W H KoppenolAm J Physiol19968944624No
103921312131.064.964.9The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. D E AtkinsonBiochemistry19684972613Yes
104042602130.0327.75163.9The biology, function, and biomedical applications of exosomes. Raghu Kalluri, Valerie S LeBleuScience202032029601No
104142572128.580.6340.3The fundamental role of epigenetic events in cancer. Peter A Jones, Stephen B BaylinNat Rev Genet200212042769No
104242562128.0110.9555.5The inflammasomes. Kate Schroder, Jurg TschoppCell201020303873No
104363802126.7146.2848.8MOLMOL: a program for display and analysis of macromolecular structures. R Koradi, M Billeter, K WüthrichJ Mol Graph19968744573Yes
104421252125.042.1442.1Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Shimon SakaguchiNat Immunol200515785760No
104542482124.083.2741.6Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Rik Derynck, Ying E ZhangNature200314534577No
104663682122.7161.2253.7GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. R A Jefferson, T A Kavanagh, M W BevanEMBO J19873327686Yes
104763652121.7130.4243.5EMBOSS: the European Molecular Biology Open Software Suite. P Rice, I Longden, A BleasbyTrends Genet200010827456Yes
104842412120.5116.2358.1Autophagy: renovation of cells and tissues. Noboru Mizushima, Masaaki KomatsuCell201122078875No
104963612120.3279.9293.3Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. B N Ames, J Mccann, E YamasakiMutat Res1975768755Yes
1050127192119.8681.19113.5DADA2: High-resolution sample inference from Illumina amplicon data. Benjamin J Callahan, Paul J McMurdie, Michael J Rosen, Andrew W Han, Amy Jo A Johnson, Susan P HolmesNat Methods201627214047Yes
105163552118.3119.0639.7Control of regulatory T cell development by the transcription factor Foxp3. Shohei Hori, Takashi Nomura, Shimon SakaguchiScience200312522256Yes
105263542118.0149.2149.7APE: Analyses of Phylogenetics and Evolution in R language. Emmanuel Paradis, Julien Claude, Korbinian StrimmerBioinformatics200414734327Yes
105342352117.5134.5167.3A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Gary J Bennett, Y-K XiePain19882837713Yes
105421162116.064.0964.1The unbiased estimation of number and sizes of arbitrary particles using the disector. D C SterioJ Microsc19846737468Yes
105542282114.0121.6160.8Angiogenic factors. J Folkman, M KlagsbrunScience19872432664No
105621132113.044.5644.6Mammalian G1 cyclins. C J SherrCell19938513492No
105721132113.035.3135.3Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. D AminoffBiochem J196113860975Yes
105842222111.082.5341.3Network biology: understanding the cell's functional organization. Albert-László Barabási, Zoltán N OltvaiNat Rev Genet200414735121No
105942192109.5127.2963.6Macrophage plasticity and polarization: in vivo veritas. Antonio Sica, Alberto MantovaniJ Clin Invest201222378047No
106063162105.3192.6564.2Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. Aleksandr V Marenich, Christopher J Cramer, Donald G TruhlarJ Phys Chem B200919366259Yes
106142102105.0106.8953.4Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. E Lander, L KruglyakNat Genet19957581446Yes
106221032103.052.5352.5Accurate description of van der Waals complexes by density functional theory including empirical corrections. Stefan GrimmeJ Comput Chem200415224390Yes
1063336402102.51081.8267.6Fiji: an open-source platform for biological-image analysis. Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert CardonaNat Methods201222743772Yes
106421012101.050.7350.7Dopamine, learning and motivation. Roy A WiseNat Rev Neurosci200415152198No
106521002100.061.161.1The plasma lecithins:cholesterol acyltransferase reaction. J A GlomsetJ Lipid Res19684868699No
106621002100.0126.9126.9Toward understanding the origin and evolution of cellular organisms. Minoru KanehisaProtein Sci201931441146No
106720982098.037.9237.9Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. P MitchellBiol Rev Camb Philos Soc19665329743No
106820972097.076.1276.1UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. D W RussellJ Pers Assess19968576833Yes
106920952095.049.3349.3Patterns of amino acids near signal-sequence cleavage sites. G von HeijneEur J Biochem19836852022Yes
107020952095.083.5283.5A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. E L BradleyArch Surg19938489394No
107120952095.074.774.7International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. C HerrmannJ Psychosom Res19979055211No
107220942094.048.8248.8Metabolomics--the link between genotypes and phenotypes. Oliver FiehnPlant Mol Biol200211860207No
107320942094.058.2358.2Japanese Classification of Gastric Carcinoma - 2nd English Edition - Japanese Gastric Cancer AssociationGastric Cancer199811957040Yes
107441882094.0147.6773.8Deciphering key features in protein structures with the new ENDscript server. Xavier Robert, Patrice GouetNucleic Acids Res201424753421Yes
107583672091.8304.7976.2Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanJ Clin Epidemiol200919631508No
107641822091.0177.6688.8The MOS social support survey. C D Sherbourne, A L StewartSoc Sci Med19912035047Yes
107720872087.042.4342.4Role of angiogenesis in tumor growth and metastasis. Judah FolkmanSemin Oncol200212516034No
107820812081.095.9996.0Method For Assay Of Intestinal Disaccharidases. A DahlqvistAnal Biochem196414106916Yes
107941602080.0108.9254.5The heat-shock proteins. S Lindquist, E A CraigAnnu Rev Genet19882853609No
108020802080.045.4745.5Defensins: antimicrobial peptides of innate immunity. Tomas GanzNat Rev Immunol200312949495No
108120782078.047.1847.2Follicular helper CD4 T cells (TFH). Shane CrottyAnnu Rev Immunol201121314428No
108241552077.5100.6150.3Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. G G Glenner, C W WongBiochem Biophys Res Commun19846375662Yes
108341502075.082.0341.0Mammalian MAP kinase signalling cascades. L Chang, M KarinNature200111242034No
108462242074.7185.0361.7Arlequin (version 3.0): an integrated software package for population genetics data analysis. Laurent Excoffier, Guillaume Laval, Stefan SchneiderEvol Bioinform Online200719325852Yes
108520732073.050.5250.5Drug-like properties and the causes of poor solubility and poor permeability. C A LipinskiJ Pharmacol Toxicol Methods200011274893No
108620732073.053.1653.2Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Gökhan S HotamisligilCell201020303879No
108720722072.059.6359.6ATP-regulated K+ channels in cardiac muscle. A NomaNature19836310409Yes
108841412070.581.7240.9Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. M Gossen, H BujardProc Natl Acad Sci U S A19921319065Yes
108941372068.5185.0392.5Stages and processes of self-change of smoking: toward an integrative model of change. J O Prochaska, C C DiClementeJ Consult Clin Psychol19836863699Yes
109020682068.071.2571.2Purinergic nerves. G BurnstockPharmacol Rev19724404211No
109120682068.093.8293.8The brain's default mode network. Marcus E RaichleAnnu Rev Neurosci201525938726No
109282582064.5392.9498.2The Satisfaction With Life Scale. E Diener, R A Emmons, R J Larsen, S GriffinJ Pers Assess198516367493Yes
109341262063.0118.4159.2Wnt/β-catenin signaling and disease. Hans Clevers, Roel NusseCell201222682243No
109482442061.0270.1767.5Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. A J Hughes, S E Daniel, L Kilford, A J LeesJ Neurol Neurosurg Psychiatry19921564476Yes
109541222061.035.5917.8Genetic regulatory mechanisms in the synthesis of proteins. F Jacob, J MonodJ Mol Biol196113718526Yes
109620612061.037.9137.9Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. J C SkouPhysiol Rev196514337569No
109741212060.5109.4454.7The unfolded protein response: from stress pathway to homeostatic regulation. Peter Walter, David RonScience201122116877No
109841202060.086.0143.0A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. G Shaw, R KamenCell19863488815Yes
109941202060.080.7840.4Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Rudolf Jaenisch, Adrian BirdNat Genet200312610534No
110020602060.050.6550.6Mechanisms of hepatic fibrogenesis. Scott L FriedmanGastroenterology200818471545No
110120572057.042.4842.5G1 events and regulation of cell proliferation. A B PardeeScience19892683075No
1102102822056.4239.1847.8Development and testing of a general amber force field. Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A CaseJ Comput Chem200415116359Yes
110320562056.052.7752.8The heme oxygenase system: a regulator of second messenger gases. M D MainesAnnu Rev Pharmacol Toxicol19979131263No
110420552055.041.4241.4Metastasis to bone: causes, consequences and therapeutic opportunities. Gregory R MundyNat Rev Cancer200212154351No
110541062053.00.00.0Plaque formation and isolation of pure lines with poliomyelitis viruses. R Dulbecco, M VogtJ Exp Med195413130792Yes
110641032051.5119.0859.5Oncology meets immunology: the cancer-immunity cycle. Daniel S Chen, Ira MellmanImmunity201323890059No
110720512051.018.7918.8The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. W W ClelandBiochim Biophys Acta196314021667Yes
110820512051.059.1259.1Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. J W LittlefieldScience196414168277Yes
110941012050.5100.9650.5Cutaneous wound healing. A J Singer, R A ClarkN Engl J Med199910471461No
111041002050.0129.9465.0Polymyositis and dermatomyositis (first of two parts). A Bohan, J B PeterN Engl J Med19751090839No
111120502050.064.9865.0Health consequences of intimate partner violence. Jacquelyn C CampbellLancet200211965295No
111261482049.3201.9167.3Parallel organization of functionally segregated circuits linking basal ganglia and cortex. G E Alexander, M R DeLong, P L StrickAnnu Rev Neurosci19863085570No
111320482048.047.9347.9Interleukin-2: inception, impact, and implications. K A SmithScience19883131876No
111420482048.039.6139.6Signalling pathways of the TNF superfamily: a double-edged sword. Bharat B AggarwalNat Rev Immunol200312949498No
111540942047.0110.8555.4New perspectives in cell adhesion: RGD and integrins. E Ruoslahti, M D PierschbacherScience19872821619No
111661282042.7197.2165.7Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. C Lord, M Rutter, A Le CouteurJ Autism Dev Disord19947814313Yes
111720422042.056.6656.7Estimating causal effects from large data sets using propensity scores. D B RubinAnn Intern Med19979382394No
111820412041.047.7747.8Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Scott L FriedmanPhysiol Rev200818195085No
111940812040.577.5738.8SIFT: Predicting amino acid changes that affect protein function. Pauline C Ng, Steven HenikoffNucleic Acids Res200312824425Yes
112040802040.0104.652.3Building better batteries. M Armand, J-M TarasconNature200818256660No
112120392039.072.7872.8Determination of glutathione and glutathione disulfide in biological samples. M E AndersonMethods Enzymol19854088074Yes
112220382038.041.7341.7Molecular bases for circadian clocks. J C DunlapCell19999988221No
112340672033.5176.4688.2The Brief Symptom Inventory: an introductory report. L R Derogatis, N MelisaratosPsychol Med19836622612Yes
112460952031.7268.9389.6Fast and sensitive protein alignment using DIAMOND. Benjamin Buchfink, Chao Xie, Daniel H HusonNat Methods201525402007Yes
112540622031.098.3849.2Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. P Liang, A B PardeeScience19921354393Yes
112620312031.051.8451.8What is cognitive reserve? Theory and research application of the reserve concept. Yaakov SternJ Int Neuropsychol Soc200211939702No
112740592029.50.00.0A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. R F Beers, I W SizerJ Biol Chem195214938361Yes
112840532026.594.8747.4Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. B A Reynolds, S WeissScience19921553558Yes
112920252025.062.3662.4Ethical authorship and publishing. Andrew J S CoatsInt J Cardiol200919046787No
113020242024.047.5747.6Calcium signaling. D E ClaphamCell19957834745No
113140482024.079.5939.8The Wnt signaling pathway in development and disease. Catriona Y Logan, Roel NusseAnnu Rev Cell Dev Biol200415473860No
113260712023.7228.6876.2Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. G Muyzer, E C de Waal, A G UitterlindenAppl Environ Microbiol19937683183Yes
113320232023.079.3379.3Perception of risk. P SlovicScience19873563507Yes
1134121342022.3376.6462.8Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell ParkinInt J Cancer201021351269Yes
113520212021.044.2344.2Biology of natural killer cells. G TrinchieriAdv Immunol19892683611No
113620212021.052.5152.5Analysis of bacteriophage T7 early RNAs and proteins on slab gels. F W StudierJ Mol Biol19734760132Yes
113720212021.059.8959.9Global epidemiology of oral and oropharyngeal cancer. Saman WarnakulasuriyaOral Oncol200918804401No
113820202020.039.0339.0CpG motifs in bacterial DNA and their immune effects. Arthur M KriegAnnu Rev Immunol200211861616No
113940382019.097.1348.6Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. M Nei, T GojoboriMol Biol Evol19863444411Yes
114020152015.060.4560.5Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? George A BonannoAm Psychol200414736317No
114160442014.7257.6185.9Scoping studies: advancing the methodology. Danielle Levac, Heather Colquhoun, Kelly K O'BrienImplement Sci201020854677Yes
114220142014.055.2355.2Trail Making Test A and B: normative data stratified by age and education. Tom N TombaughArch Clin Neuropsychol200415010086Yes
114380542013.5302.1575.5The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. T F Heatherton, L T Kozlowski, R C Frecker, K O FagerströmBr J Addict19911932883Yes
114420102010.058.2758.3Protein oxidation and aging. E R StadtmanScience19921355616No
114520092009.046.7846.8DAMPs, PAMPs and alarmins: all we need to know about danger. Marco E BianchiJ Leukoc Biol200717032697No
114620082008.096.0396.0Performance-oriented assessment of mobility problems in elderly patients. M E TinettiJ Am Geriatr Soc19863944402Yes
114720082008.041.6241.6XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. D E McReeJ Struct Biol199910222271Yes
114820082008.00.00.0Antigen-antibody reactions in gels. O OuchterlonyActa Pathol Microbiol Scand194918143039Yes
114920052005.034.8134.8ATM and related protein kinases: safeguarding genome integrity. Yosef ShilohNat Rev Cancer200312612651No
115020052005.042.3842.4Developmental regulation of the growth plate. Henry M KronenbergNature200312748651No
115160142004.7181.6560.6Estimating the mean and variance from the median, range, and the size of a sample. Stela Pudar Hozo, Benjamin Djulbegovic, Iztok HozoBMC Med Res Methodol200515840177Yes
115220042004.050.2750.3Determination and analysis of urea and guanidine hydrochloride denaturation curves. C N PaceMethods Enzymol19863773761Yes
115320032003.038.5938.6Antiviral actions of interferons. C E SamuelClin Microbiol Rev200111585785No
115420012001.083.2983.3A rating scale for drug-induced akathisia. T R BarnesBr J Psychiatry19892574607Yes
115520002000.040.6640.7The lasso method for variable selection in the Cox model. R TibshiraniStat Med19979044528Yes
115619991999.036.6536.6In situ hybridization: an improved whole-mount method for Xenopus embryos. R M HarlandMethods Cell Biol19911811161Yes
115719991999.050.9551.0Flow-mediated endothelial mechanotransduction. P F DaviesPhysiol Rev19957624393No
115819981998.043.8243.8Structural design and molecular evolution of a cytokine receptor superfamily. J F BazanProc Natl Acad Sci U S A19902169613Yes
115919981998.039.4539.5DNA topoisomerases: structure, function, and mechanism. J J ChampouxAnnu Rev Biochem200111395412No
116019971997.022.1222.1Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? J V NeelAm J Hum Genet196213937884Yes
116119951995.055.8355.8Flavonoids as antioxidants. P G PiettaJ Nat Prod200010924197No
116279751993.8326.1181.5jModelTest 2: more models, new heuristics and parallel computing. Diego Darriba, Guillermo L Taboada, Ramón Doallo, David PosadaNat Methods201222847109Yes
116319931993.079.8479.8Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. Konrad M AndrassyKidney Int201323989362Yes
116419921992.042.3742.4The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. U E LoeningBiochem J19675339944Yes
116519901990.00.00.0On respiratory impairment in cancer cells. O WarburgScience195613351639Yes
116619901990.047.8247.8Interfaces and the driving force of hydrophobic assembly. David ChandlerNature200516193038No
116719901990.068.5968.6The emerging role of lncRNAs in cancer. Maite HuarteNat Med201526540387No
116819881988.041.5841.6TRP channels as cellular sensors. David E ClaphamNature200314654832No
116939751987.585.5142.8Lessons from hereditary colorectal cancer. K W Kinzler, B VogelsteinCell19968861899No
117019871987.054.7454.7The biology of interleukin-6. T KishimotoBlood19892473791No
117119871987.040.7440.7Mechanisms of intracellular protein transport. J E RothmanNature19947969419No
117279451986.2235.0258.8Antibiotic susceptibility testing by a standardized single disk method. A W Bauer, W M Kirby, J C Sherris, M TurckAm J Clin Pathol19665325707Yes
117319861986.066.0166.0The use of a plus-maze to measure anxiety in the mouse. R G ListerPsychopharmacology (Berl)19873110839Yes
117439721986.090.9245.5Base-calling of automated sequencer traces using phred. II. Error probabilities. B Ewing, P GreenGenome Res19989521922Yes
117539701985.088.0144.0The DNA-damage response in human biology and disease. Stephen P Jackson, Jiri BartekNature200919847258No
117639691984.586.2643.1The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. A J Ridley, A HallCell19921643657Yes
117779381984.5504.0126.0Rayyan-a web and mobile app for systematic reviews. Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz, Ahmed ElmagarmidSyst Rev201627919275Yes
1178138891984.1306.2443.7Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank SpelemanGenome Biol200212184808Yes
117919841984.043.2943.3Neutrophils and immunity: challenges and opportunities. Carl NathanNat Rev Immunol200616498448No
118039671983.590.1945.1The acute respiratory distress syndrome. L B Ware, M A MatthayN Engl J Med200010793167No
118179291982.2193.148.3Cancer-related inflammation. Alberto Mantovani, Paola Allavena, Antonio Sica, Frances BalkwillNature200818650914No
118219781978.048.5448.5Negative refraction makes a perfect lens J B PendryPhys Rev Lett200011041972Yes
118319761976.038.538.5Approaching the asymptote? Evolution and revolution in immunology. C A JanewayCold Spring Harb Symp Quant Biol19892700931No
118439501975.098.0149.0Leptin and the regulation of body weight in mammals. J M Friedman, J L HalaasNature19989796811No
118539481974.0115.9958.0Mechanisms of salinity tolerance. Rana Munns, Mark TesterAnnu Rev Plant Biol200818444910No
118619731973.054.1954.2Determination of minimum inhibitory concentrations. J M AndrewsJ Antimicrob Chemother200111420333Yes
118739461973.0116.958.5Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. James J Gross, Oliver P JohnJ Pers Soc Psychol200312916575Yes
118819731973.038.9338.9DNA methylation and human disease. Keith D RobertsonNat Rev Genet200516136652No
1189138111973.0315.5245.1Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya YamanakaCell200718035408Yes
119019721972.052.7252.7Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. J FolkmanN Engl J Med19957491141No
119139441972.0117.3958.7Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). Kathryn M Connor, Jonathan R T DavidsonDepress Anxiety200312964174Yes
119219721972.061.5161.5A new automated colorimetric method for measuring total oxidant status. Ozcan ErelClin Biochem200516214125Yes
119339431971.586.8743.4Issues and challenges facing rechargeable lithium batteries. J M Tarascon, M ArmandNature200111713543Yes
119439431971.589.4644.7Liver fibrosis. Ramón Bataller, David A BrennerJ Clin Invest200515690074No
119519701970.0117.54117.5Understanding Bland Altman analysis. Davide GiavarinaBiochem Med (Zagreb)201526110027No
119619681968.090.7290.7A modified card sorting test sensitive to frontal lobe defects. H E NelsonCortex19761009768Yes
119739361968.0108.1454.1Insulin-like growth factors and their binding proteins: biological actions. J I Jones, D R ClemmonsEndocr Rev19957758431No
119839361968.0523.97262.0Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation. Ivica Letunic, Peer BorkNucleic Acids Res202133885785Yes
119939351967.5109.654.8Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. B J Marshall, J R WarrenLancet19846145023Yes
120019671967.070.3670.4Pro-resolving lipid mediators are leads for resolution physiology. Charles N SerhanNature201424899309No
1201216351966.8538.148.9PLINK: a tool set for whole-genome association and population-based linkage analyses. Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C ShamAm J Hum Genet200717701901Yes
120219651965.049.249.2Hydrogels for biomedical applications. Allan S HoffmanAdv Drug Deliv Rev200211755703No
120319631963.034.8734.9Signaling--2000 and beyond. T HunterCell200010647936No
120419631963.062.7262.7Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Sergio PecorelliInt J Gynaecol Obstet200919367689No
120539261963.0132.9566.5PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. Daniel R Roe, Thomas E CheathamJ Chem Theory Comput201326583988Yes
120658861962.0191.3363.8AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. P G Reeves, F H Nielsen, G C FaheyJ Nutr19938229312No
120739231961.596.6748.3Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. P J Barnes, M KarinN Engl J Med19979091804No
120819611961.00.00.0Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. M KunitzJ Gen Physiol194719873496Yes
120919601960.057.7957.8Intracellular calcium homeostasis. E CarafoliAnnu Rev Biochem19873304139No
121019591959.047.2947.3Python: a programming language for software integration and development. M F SannerJ Mol Graph Model199910660911Yes
121119571957.061.2761.3Epidemiological features of chronic low-back pain. G B AnderssonLancet199910470716No
121239121956.0139.7169.9ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. M Gardes, T D BrunsMol Ecol19938180733Yes
121339111955.5125.5862.8Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. A C Chang, S N CohenJ Bacteriol1978149110Yes
121439081954.0135.5967.8Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. Sarvajeet Singh Gill, Narendra TutejaPlant Physiol Biochem201020870416No
121519531953.045.045.0Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. B L WajchenbergEndocr Rev200011133069No
121619531953.045.945.9The global health burden of infection-associated cancers in the year 2002. Donald Maxwell ParkinInt J Cancer200616404738Yes
121719521952.060.1960.2Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Berislav V ZlokovicNat Rev Neurosci201122048062No
121819511951.041.0241.0The immunopathogenesis of sepsis. Jonathan CohenNature200212490963No
121919511951.062.2662.3Grounded cognition. Lawrence W BarsalouAnnu Rev Psychol200817705682No
122019511951.047.9247.9Pathogen recognition and inflammatory signaling in innate immune defenses. Trine H MogensenClin Microbiol Rev200919366914No
122119501950.00.00.0Influences of glucose loading and of injected insulin on hepatic glucose output. R SteeleAnn N Y Acad Sci195913833973Yes
122219491949.061.761.7Calculation of substrate oxidation rates in vivo from gaseous exchange. K N FraynJ Appl Physiol Respir Environ Exerc Physiol19836618956Yes
122319491949.00.00.0On estimating the relation between blood group and disease. B WoolfAnn Hum Genet195514388528Yes
122419471947.079.6379.6Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. A FleckensteinAnnu Rev Pharmacol Toxicol1977326161No
122538941947.065.2532.6Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. I W McLean, P K NakaneJ Histochem Cytochem19744374474Yes
122619471947.034.1734.2Mechanisms of alternative pre-messenger RNA splicing. Douglas L BlackAnnu Rev Biochem200312626338No
122738941947.0144.4172.2Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. W R Morrison, L M SmithJ Lipid Res196414221106Yes
122858341944.7107.2835.8Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Jason D Fontenot, Marc A Gavin, Alexander Y RudenskyNat Immunol200312612578Yes
122938881944.0131.0565.5Mathematical model for studying genetic variation in terms of restriction endonucleases. M Nei, W H LiProc Natl Acad Sci U S A1979291943Yes
123058291943.0120.1740.1Rapid and efficient site-specific mutagenesis without phenotypic selection. T A Kunkel, J D Roberts, R A ZakourMethods Enzymol19873323813Yes
123119421942.061.1461.1Sick individuals and sick populations. G RoseInt J Epidemiol19853872850Yes
123219421942.037.5837.6Systems biology: a brief overview. Hiroaki KitanoScience200211872829No
123319421942.038.9539.0The complex language of chromatin regulation during transcription. Shelley L BergerNature200717522673No
123438831941.594.5847.3Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. J G Rheinwald, H GreenCell19751052771Yes
123519411941.037.0137.0Notch signalling: a simple pathway becomes complex. Sarah J BrayNat Rev Mol Cell Biol200616921404No
123619401940.039.7639.8Thrombin signalling and protease-activated receptors. S R CoughlinNature200011001069No
123719401940.039.3439.3The expanding role of mitochondria in apoptosis. X WangGenes Dev200111711427No
123819401940.00.00.0The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. S V BoydenJ Exp Med195114803635Yes
123919391939.064.464.4Intermediate filaments as mechanical integrators of cellular space. E LazaridesNature19807188712Yes
124019371937.041.1541.1Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. A BreslowAnn Surg19705477666Yes
124119351935.049.8649.9Dengue and dengue hemorrhagic fever. D J GublerClin Microbiol Rev19989665979No
124219341934.060.2960.3Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. J P ChamberlainAnal Biochem1979543547Yes
124319321932.055.2855.3Excitotoxic cell death. D W ChoiJ Neurobiol19921361523No
124419321932.00.00.0Dendritic organization in the neurons of the visual and motor cortices of the cat. D A ShollJ Anat195313117757Yes
124519311931.057.4857.5Calbindin D-28k and parvalbumin in the rat nervous system. M R CelioNeuroscience19902199841Yes
124619301930.042.2142.2Gene finding in novel genomes. Ian KorfBMC Bioinformatics200415144565Yes
124738571928.590.2545.1Neuronal oscillations in cortical networks. György Buzsáki, Andreas DraguhnScience200415218136No
124819271927.042.7442.7Signal sequences. The limits of variation. G von HeijneJ Mol Biol19854032478Yes
124938531926.594.7647.4The endophenotype concept in psychiatry: etymology and strategic intentions. Irving I Gottesman, Todd D GouldAm J Psychiatry200312668349No
125019261926.050.5850.6DNA topoisomerase poisons as antitumor drugs. L F LiuAnnu Rev Biochem19892549853No
125119261926.099.099.0Subjective well-being. E DienerPsychol Bull19846399758No
125238501925.0102.7651.4Inositol phosphates and cell signalling. M J Berridge, R F IrvineNature19892550825No
125319251925.042.9943.0High-speed scanning in human memory. S SternbergScience19665939936Yes
125419241924.0124.33124.3High-performance medicine: the convergence of human and artificial intelligence. Eric J TopolNat Med201930617339No
125519231923.023.223.2A theory of cerebellar cortex. D MarrJ Physiol19695784296Yes
125638461923.0122.7361.4Oxygen toxicity, oxygen radicals, transition metals and disease. B Halliwell, J M GutteridgeBiochem J19846326753No
125738421921.073.5936.8Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. M Karin, Y Ben-NeriahAnnu Rev Immunol200010837071No
125819201920.083.5683.6Brain dopamine receptors. P SeemanPharmacol Rev19806117090No
125976771919.2298.9874.7A simple technique for quantitation of low levels of DNA damage in individual cells. N P Singh, M T McCoy, R R Tice, E L SchneiderExp Cell Res19883345800Yes
126019191919.046.5246.5Episodic memory: from mind to brain. Endel TulvingAnnu Rev Psychol200211752477Yes
126119181918.045.6745.7The genetics of ageing. Cynthia J KenyonNature201020336132No
126257521917.3189.3263.1Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. L Excoffier, P E Smouse, J M QuattroGenetics19921644282Yes
126319171917.041.5641.6A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. J SantaLuciaProc Natl Acad Sci U S A19989465037Yes
126419161916.046.9847.0DNA topoisomerases. J C WangAnnu Rev Biochem19852992360No
126519161916.033.833.8The regulation of E2F by pRB-family proteins. N DysonGenes Dev19989694791No
126619151915.039.1339.1Mechanisms of cancer drug resistance. Michael M GottesmanAnnu Rev Med200211818492No
126738291914.50.00.0Acetylornithinase of Escherichia coli: partial purification and some properties. H J Vogel, D M BonnerJ Biol Chem195613278318Yes
126819141914.040.0140.0A cell culture model for T lymphocyte clonal anergy. R H SchwartzScience19902113314Yes
126919141914.054.8254.8The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. G P ChrousosN Engl J Med19957715646No
127019141914.042.1642.2The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Michael R LieberAnnu Rev Biochem201020192759No
127119131913.056.2156.2Inhibited spontaneous emission in solid-state physics and electronics. E YablonovitchPhys Rev Lett198710034639Yes
127219131913.045.1545.1The dawning era of polymer therapeutics. Ruth DuncanNat Rev Drug Discov200312750738No
127338251912.5122.0161.0Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. R L Heath, L PackerArch Biochem Biophys19685655425Yes
127476491912.2188.6547.2p53 mutations in human cancers. M Hollstein, D Sidransky, B Vogelstein, C C HarrisScience19911905840No
127538231911.5120.2360.1Understanding interobserver agreement: the kappa statistic. Anthony J Viera, Joanne M GarrettFam Med200515883903Yes
127619111911.046.1446.1Cancer chemoprevention with dietary phytochemicals. Young-Joon SurhNat Rev Cancer200314570043No
127738191909.598.3349.2Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering S Nie, S R EmoryScience19979027306Yes
127838181909.084.9142.5Parkinson's disease: mechanisms and models. William Dauer, Serge PrzedborskiNeuron200312971891No
127919091909.040.6140.6The etiology of chondromalacia patellae. R E OuterbridgeJ Bone Joint Surg Br196114038135Yes
128038171908.5130.2365.1Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. M H Zweig, G CampbellClin Chem19938472349No
128119081908.046.2646.3Thioredoxin. A HolmgrenAnnu Rev Biochem19853896121No
128219081908.053.453.4Introduction and General Overview of Cyclodextrin Chemistry. József SzejtliChem Rev199811848947Yes
128319071907.062.962.9Physiological actions of taurine. R J HuxtablePhysiol Rev19921731369No
128419061906.044.1844.2The retinal pigment epithelium in visual function. Olaf StraussPhysiol Rev200515987797No
128519021902.054.354.3In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. T R ChenExp Cell Res197765285Yes
128619021902.043.1243.1Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Jeffrey A EngelmanNat Rev Cancer200919629070No
128719021902.0112.75112.8Making sense of implementation theories, models and frameworks. Per NilsenImplement Sci201525895742Yes
128819011901.058.6158.6Matching methods for causal inference: A review and a look forward. Elizabeth A StuartStat Sci201020871802Yes
128919001900.00.00.0The oxidation of ribonuclease with performic acid. C H HirsJ Biol Chem195613319283Yes
129075991899.8185.6446.4Epithelial-mesenchymal transitions in development and disease. Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela NietoCell200919945376No
129137991899.5114.9457.5Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Stephen M Smith, Thomas E NicholsNeuroimage200918501637Yes
129218991899.063.0363.0The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. G S ManningQ Rev Biophys1978353876No
129356961898.7166.255.4Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Helga Thorvaldsdóttir, James T Robinson, Jill P MesirovBrief Bioinform201322517427Yes
129418981898.052.7752.8Cell biology and molecular basis of denitrification. W G ZumftMicrobiol Mol Biol Rev19979409151No
129556921897.3341.18113.7Research diagnostic criteria: rationale and reliability. R L Spitzer, J Endicott, E RobinsArch Gen Psychiatry1978655775Yes
129618941894.041.1641.2The mitogen-activated protein kinase signal transduction pathway. R J DavisJ Biol Chem19938325833No
129737861893.0118.1959.1Efficient pseudopotentials for plane-wave calculations. N Troullier, J L MartinsPhys Rev B Condens Matter19919997467Yes
129856761892.0145.1448.4Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. G S Hotamisligil, N S Shargill, B M SpiegelmanScience19937678183Yes
129918921892.053.3853.4Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. A DunaifEndocr Rev19979408743No
130018901890.016.0816.1Positional information and the spatial pattern of cellular differentiation. L WolpertJ Theor Biol19694390734Yes
130156701890.0153.0851.0trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. Salvador Capella-Gutiérrez, José M Silla-Martínez, Toni GabaldónBioinformatics200919505945Yes
130218891889.045.5745.6The hydrogen bond in the solid state. Thomas SteinerAngew Chem Int Ed Engl200212491444Yes
130337781889.087.0743.5PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. Alexander W Schüttelkopf, Daan M F van AaltenActa Crystallogr D Biol Crystallogr200415272157Yes
130437771888.585.0242.5Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. T Miyashita, J C ReedCell19957834749Yes
130518881888.059.2859.3Receiver operating characteristic curve in diagnostic test assessment. Jayawant N MandrekarJ Thorac Oncol201020736804No
130637751887.5107.053.5Event-related EEG/MEG synchronization and desynchronization: basic principles. G Pfurtscheller, F H Lopes da SilvaClin Neurophysiol199910576479No
130718871887.059.9560.0Complete nucleotide sequence of the Escherichia coli plasmid pBR322. J G SutcliffeCold Spring Harb Symp Quant Biol1979383387Yes
130818871887.058.8358.8The Gingival Index, the Plaque Index and the Retention Index Systems. H LöeJ Periodontol19675237684Yes
130918871887.064.9464.9Guided Search 2.0 A revised model of visual search. J M WolfePsychon Bull Rev199424203471Yes
131018841884.053.8753.9Multiple imputation: a primer. J L SchaferStat Methods Med Res199910347857No
131137671883.5117.258.6An efficient mRNA-dependent translation system from reticulocyte lysates. H R Pelham, R J JacksonEur J Biochem1976823012Yes
1312150651883.1367.9246.0Electric field effect in atomically thin carbon films. K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A FirsovScience200415499015Yes
131318821882.069.3369.3Recognition-by-components: a theory of human image understanding. Irving BiedermanPsychol Rev19873575582Yes
131475271881.8182.145.5Improved optimization for the robust and accurate linear registration and motion correction of brain images. Mark Jenkinson, Peter Bannister, Michael Brady, Stephen SmithNeuroimage200212377157Yes
131537611880.589.6744.8The future of genetic studies of complex human diseases. N Risch, K MerikangasScience19968801636Yes
131637611880.5129.0264.5Regulation of microRNA biogenesis. Minju Ha, V Narry KimNat Rev Mol Cell Biol201425027649No
131718801880.069.3769.4Cognitive reserve in ageing and Alzheimer's disease. Yaakov SternLancet Neurol201223079557No
131875181879.5252.3763.1Reporting results of cancer treatment. A B Miller, B Hoogstraten, M Staquet, A WinklerCancer19817459811Yes
131956381879.3196.8265.6Molecular mechanisms of epithelial-mesenchymal transition. Samy Lamouille, Jian Xu, Rik DerynckNat Rev Mol Cell Biol201424556840No
132018791879.078.8478.8The drug abuse screening test. H A SkinnerAddict Behav19827183189Yes
132118791879.049.8849.9Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. Robert E MarxJ Oral Maxillofac Surg200312966493Yes
132218791879.050.9150.9Systemic lupus erythematosus. George C TsokosN Engl J Med201122129255No
132337541877.086.1143.1The Fas death factor. S Nagata, P GolsteinScience19957533326No
132418761876.041.1241.1Cellular mechanisms of insulin resistance. G I ShulmanJ Clin Invest200010903330No
132518731873.090.5790.6A simple fluorometric assay for lipoperoxide in blood plasma. K YagiBiochem Med1976962904Yes
132618731873.039.0939.1Maintenance of C. elegans. Theresa StiernagleWormBook200618050451No
132756181872.7450.44150.1An interactive web-based dashboard to track COVID-19 in real time. Ensheng Dong, Hongru Du, Lauren GardnerLancet Infect Dis202032087114Yes
132818721872.068.4368.4Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. D R JaneroFree Radic Biol Med19902079232No
132937431871.568.1434.1Rho GTPases in cell biology. Sandrine Etienne-Manneville, Alan HallNature200212478284No
133037401870.0125.6462.8Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. G Di Chiara, A ImperatoProc Natl Acad Sci U S A19882899326Yes
133118691869.073.4873.5Predicting basal metabolic rate, new standards and review of previous work. W N SchofieldHum Nutr Clin Nutr19854044297Yes
133218691869.039.9640.0Exploring complex networks. S H StrogatzNature200111258382No
133356041868.0125.5241.8A new statistical method for haplotype reconstruction from population data. M Stephens, N J Smith, P DonnellyAm J Hum Genet200111254454Yes
133418671867.050.850.8A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. P J GoodfordJ Med Chem19853892003Yes
133537301865.078.4539.2Monocyte and macrophage heterogeneity. Siamon Gordon, Philip R TaylorNat Rev Immunol200516322748No
133693241864.8221.4744.3Mapping and quantifying mammalian transcriptomes by RNA-Seq. Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara WoldNat Methods200818516045Yes
1337130391862.7464.9566.4Assessing the quality of reports of randomized clinical trials: is blinding necessary? A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuayControl Clin Trials19968721797Yes
133818611861.037.3837.4Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. R J KaufmanGenes Dev199910346810No
133918611861.041.9341.9Integrating cell-signalling pathways with NF-kappaB and IKK function. Neil D PerkinsNat Rev Mol Cell Biol200717183360No
134018611861.060.1160.1Cognitive reserve. Yaakov SternNeuropsychologia200919467352No
134118611861.048.948.9Molecular dissection of reactive astrogliosis and glial scar formation. Michael V SofroniewTrends Neurosci200919782411No
134218601860.047.7147.7From sensation to cognition. M M MesulamBrain19989648540No
134318601860.041.4741.5Fabrication of novel biomaterials through molecular self-assembly. Shuguang ZhangNat Biotechnol200314520402No
134437191859.5103.1651.6EQ-5D: a measure of health status from the EuroQol Group. R Rabin, F de CharroAnn Med200111491192No
134537191859.578.7339.4Raster3D: photorealistic molecular graphics. E A Merritt, D J BaconMethods Enzymol199718488322Yes
134618581858.051.1451.1Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. D M NevilleJ Biol Chem19715127429Yes
134737161858.076.838.4Identification of common molecular subsequences. T F Smith, M S WatermanJ Mol Biol19817265238Yes
134818581858.043.8743.9The mitochondrial permeability transition pore and its role in cell death. M CromptonBiochem J199910393078No
134918551855.048.648.6Hepatitis B virus infection. W M LeeN Engl J Med19979392700No
135018541854.041.6241.6Global cancer statistics in the year 2000. D M ParkinLancet Oncol200111905707No
135118531853.045.1745.2Evolutionary relationship of DNA sequences in finite populations. F TajimaGenetics19836628982Yes
135237001850.076.7738.4Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. C D Nobes, A HallCell19957536630Yes
135318481848.048.5648.6The comet assay for DNA damage and repair: principles, applications, and limitations. Andrew R CollinsMol Biotechnol200415004294No
135455431847.7138.6946.2Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Z N Oltvai, C L Milliman, S J KorsmeyerCell19938358790Yes
135536951847.5134.1667.1The need to belong: desire for interpersonal attachments as a fundamental human motivation. R F Baumeister, M R LearyPsychol Bull19957777651No
135636941847.0151.4275.7mTOR Signaling in Growth, Metabolism, and Disease. Robert A Saxton, David M SabatiniCell201728283069No
135773831845.8178.6644.7Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. A Shevchenko, M Wilm, O Vorm, M MannAnal Chem19968779443Yes
1358147641845.5414.5551.8Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A ErlichScience19882448875Yes
135936911845.552.826.4Immunoassay of insulin with insulin-antibody precipitate. C N Hales, P J RandleBiochem J196313952078Yes
136018451845.00.00.0Cognitive maps in rats and men. E C TolmanPsychol Rev194818870876Yes
136136891844.5133.0966.5Pain assessment: global use of the Brief Pain Inventory. C S Cleeland, K M RyanAnn Acad Med Singap19948080219No
1362147471843.4613.3176.7The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jörg Peplies, Frank Oliver GlöcknerNucleic Acids Res201323193283Yes
136318431843.044.0244.0Integration, scaling, space-group assignment and post-refinement. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124693Yes
136455261842.0122.1540.7Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Michael W Pfaffl, Graham W Horgan, Leo DempfleNucleic Acids Res200211972351Yes
136536831841.5142.3871.2ROS function in redox signaling and oxidative stress. Michael Schieber, Navdeep S ChandelCurr Biol201424845678No
136636821841.082.0241.0Amino acid substitution matrices from protein blocks. S Henikoff, J G HenikoffProc Natl Acad Sci U S A19921438297Yes
136718411841.084.6384.6Determinants of low birth weight: methodological assessment and meta-analysis. M S KramerBull World Health Organ19873322602No
136818401840.055.6855.7The atom economy--a search for synthetic efficiency. B M TrostScience19911962206Yes
136918401840.052.752.7Perceptual symbol systems. L W BarsalouBehav Brain Sci199911301525No
137036791839.5129.6864.8miRBase: annotating high confidence microRNAs using deep sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201424275495Yes
137118391839.045.0745.1Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Fiona TurnbullLancet200314615107Yes
137236771838.599.7649.9Biofilms: survival mechanisms of clinically relevant microorganisms. Rodney M Donlan, J William CostertonClin Microbiol Rev200211932229No
137318381838.041.4841.5DNA topoisomerases. J C WangAnnu Rev Biochem19968811192No
137436751837.5338.97169.5WHO Declares COVID-19 a Pandemic. Domenico Cucinotta, Maurizio VanelliActa Biomed202032191675Yes
137573491837.2341.3385.3Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. D J Sahn, A DeMaria, J Kisslo, A WeymanCirculation1978709763Yes
137636741837.0120.5160.3Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. R A DeFronzo, E FerranniniDiabetes Care19912044434No
137718361836.050.150.1Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Ralph A DefronzoDiabetes200919336687No
137873391834.8203.6650.9Comorbidity measures for use with administrative data. A Elixhauser, C Steiner, D R Harris, R M CoffeyMed Care19989431328Yes
137936691834.5110.4955.2New method for quantitative determination of uronic acids. N Blumenkrantz, G Asboe-HansenAnal Biochem19734269305Yes
138018341834.068.2368.2Physiological aspects of primary hypertension. B FolkowPhysiol Rev19826461865No
138136671833.5105.1252.6Molecular mechanisms and clinical applications of angiogenesis. Peter Carmeliet, Rakesh K JainNature201121593862No
138218331833.035.4535.5Cancer and the chemokine network. Fran BalkwillNat Rev Cancer200415229479No
138318331833.036.4136.4MicroRNA biogenesis: coordinated cropping and dicing. V Narry KimNat Rev Mol Cell Biol200515852042No
138436661833.0154.4377.2Cancer immunotherapy using checkpoint blockade. Antoni Ribas, Jedd D WolchokScience201829567705No
138554971832.3121.1940.4A rapid method for the isolation of functional thymus-derived murine lymphocytes. M H Julius, E Simpson, L A HerzenbergEur J Immunol19734587740Yes
138636641832.076.3338.2Cell death: critical control points. Nika N Danial, Stanley J KorsmeyerCell200414744432No
138718311831.066.166.1Why patients use alternative medicine: results of a national study. J A AstinJAMA19989605899Yes
138818311831.054.2554.2An overview of brominated flame retardants in the environment. Cynthia A de WitChemosphere200211999784No
138918301830.017.7417.7A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. D A RobinsonIEEE Trans Biomed Eng196314121113Yes
139018291829.044.4844.5A classification of hand preference by association analysis. M AnnettBr J Psychol19705457503Yes
139136541827.087.7343.9Variations in the pattern of pubertal changes in boys. W A Marshall, J M TannerArch Dis Child19705440182Yes
139218271827.036.7636.8Molecular regulation of vessel maturation. Rakesh K JainNat Med200312778167No
139318241824.050.550.5Protein denaturation. C TanfordAdv Protein Chem19684882248No
139418241824.041.3941.4Evolutionary rate at the molecular level. M KimuraNature19685637732Yes
139518231823.070.0970.1Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. H U WittchenJ Psychiatr Res19948064641No
1396109301821.7318.9553.2Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939837Yes
139718171817.039.9439.9Recognition of microorganisms and activation of the immune response. Ruslan MedzhitovNature200717943118No
139818141814.049.4249.4Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. H LeVineProtein Sci19938453378Yes
139918131813.051.0451.0Oxidative stress: oxidants and antioxidants. H SiesExp Physiol19979129943No
140036241812.087.5543.8Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Christian Haass, Dennis J SelkoeNat Rev Mol Cell Biol200717245412No
140136231811.592.4146.2Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. K D McCarthy, J de VellisJ Cell Biol19806248568Yes
140218111811.054.6954.7The inverse care law. J T HartLancet19714100731Yes
140318111811.00.00.0The influence of some cations on an adenosine triphosphatase from peripheral nerves. J C SkouBiochim Biophys Acta195713412736Yes
140418111811.055.0655.1Social relationships and health. Sheldon CohenAm Psychol200415554821No
140554311810.3102.8234.3Surfing the p53 network. B Vogelstein, D Lane, A J LevineNature200011099028No
140618081808.019.9620.0Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. S CohenJ Biol Chem196213880319Yes
140718071807.058.9559.0Heavy metal intensification of DAB-based HRP reaction product. J C AdamsJ Histochem Cytochem19817252134Yes
140818031803.042.5742.6Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. D LavanchyJ Viral Hepat200414996343No
140918031803.066.1566.2The Resonating Valence Bond State in La2CuO4 and Superconductivity. P W AndersonScience198717818979Yes
141036051802.5102.6251.3Receptive fields and functional architecture of monkey striate cortex. D H Hubel, T N WieselJ Physiol19684966457Yes
141118021802.044.9444.9Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. B Winkel-ShirleyPlant Physiol200111402179No
141290101802.0235.1447.0Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary KingDiabetes Care200415111519Yes
141318021802.075.8275.8Optical properties of biological tissues: a review. Steven L JacquesPhys Med Biol201323666068No
141454051801.7112.6637.6A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J H Zhang, T D Chung, K R OldenburgJ Biomol Screen199910838414Yes
141536011800.592.6546.3Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. M A Nitsche, W PaulusJ Physiol200010990547Yes
141653971799.0165.1455.0Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. P A Wolf, R D Abbott, W B KannelStroke19911866765Yes
141717991799.048.8648.9Leptospirosis. P N LevettClin Microbiol Rev200111292640No
141817991799.049.8249.8Porous scaffold design for tissue engineering. Scott J HollisterNat Mater200516003400No
141917981798.056.5156.5Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. M ZasloffProc Natl Acad Sci U S A19873299384Yes
142035961798.0123.3561.7The Oswestry Disability Index. J C Fairbank, P B PynsentSpine (Phila Pa 1976)200011074683No
142117971797.052.6852.7phangorn: phylogenetic analysis in R. Klaus Peter SchliepBioinformatics201121169378Yes
142217971797.053.0853.1Aging, cellular senescence, and cancer. Judith CampisiAnnu Rev Physiol201323140366No
142353871795.7142.0747.4Median-joining networks for inferring intraspecific phylogenies. H J Bandelt, P Forster, A RöhlMol Biol Evol199910331250Yes
142417951795.062.4862.5A cortical network for directed attention and unilateral neglect. M M MesulamAnn Neurol19817032417No
142517951795.042.4342.4Type III protein secretion systems in bacterial pathogens of animals and plants. C J HueckMicrobiol Mol Biol Rev19989618447No
142671801795.0273.7568.4Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanInt J Surg201020171303No
142717941794.048.1648.2New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. R Y TsienBiochemistry19806770893Yes
142817941794.035.835.8The effect of infections on susceptibility to autoimmune and allergic diseases. Jean-Francois BachN Engl J Med200212239261No
142917941794.00.00.0The measurement of volume changes in human limbs. R J WhitneyJ Physiol195313085295Yes
143035861793.0181.390.7Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. M Mihara, M UchiyamaAnal Biochem1978655387Yes
143117931793.043.9644.0Adipose tissue, adipokines, and inflammation. Giamila FantuzziJ Allergy Clin Immunol200515867843No
143235861793.0249.34124.7Interactive Tree Of Life (iTOL) v4: recent updates and new developments. Ivica Letunic, Peer BorkNucleic Acids Res201930931475Yes
143317921792.047.8847.9What we can do and what we cannot do with fMRI. Nikos K LogothetisNature200818548064No
143435831791.5116.0258.0Saliency, switching, attention and control: a network model of insula function. Vinod Menon, Lucina Q UddinBrain Struct Funct201020512370No
143517911791.0102.5102.5Estimability and estimation in case-referent studies. O MiettinenAm J Epidemiol19761251836Yes
143635811790.5110.4955.2Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Jennifer A Doudna, Emmanuelle CharpentierScience201425430774No
143717901790.036.6436.6Structure and regulation of voltage-gated Ca2+ channels. W A CatterallAnnu Rev Cell Dev Biol200011031246No
143835791789.5159.9680.0Multiple receptors for dopamine. J W Kebabian, D B CalneNature1979215920No
143917891789.059.1759.2Large-scale neurocognitive networks and distributed processing for attention, language, and memory. M M MesulamAnn Neurol19902260847No
144017891789.036.1436.1Points of control in inflammation. Carl NathanNature200212490957No
144135761788.085.9443.0Protein folding in the cell. M J Gething, J SambrookNature19921731198No
144235761788.086.2643.1Macrophage diversity enhances tumor progression and metastasis. Bin-Zhi Qian, Jeffrey W PollardCell201020371344No
144317861786.042.942.9Growth of the plant cell wall. Daniel J CosgroveNat Rev Mol Cell Biol200516261190No
144435711785.598.9749.5The precuneus: a review of its functional anatomy and behavioural correlates. Andrea E Cavanna, Michael R TrimbleBrain200616399806No
144517851785.058.3658.4The crisis in antibiotic resistance. H C NeuScience19921509257No
144635701785.0126.0163.0The transtheoretical model of health behavior change. J O Prochaska, W F VelicerAm J Health Promot199710170434No
144717841784.053.2453.2Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. U UngerstedtActa Physiol Scand Suppl19714332693Yes
144871111777.8138.2434.6Stem cells, cancer, and cancer stem cells. T Reya, S J Morrison, M F Clarke, I L WeissmanNature200111689955No
144935551777.588.0544.0Maturation of the head of bacteriophage T4. I. DNA packaging events. U K Laemmli, M FavreJ Mol Biol19734204102Yes
145017771777.032.7432.7Cellular roles of DNA topoisomerases: a molecular perspective. James C WangNat Rev Mol Cell Biol200212042765No
145117771777.036.8136.8Excitatory actions of gaba during development: the nature of the nurture. Yehezkel Ben-AriNat Rev Neurosci200212209121No
145217771777.038.6738.7The hippo signaling pathway in development and cancer. Duojia PanDev Cell201020951342No
145317771777.059.3659.4Functional and effective connectivity: a review. Karl J FristonBrain Connect201122432952No
145453291776.3140.5346.8The metabolic syndrome--a new worldwide definition. K George M M Alberti, Paul Zimmet, Jonathan ShawLancet200516182882Yes
145517761776.057.9457.9Pineal melatonin: cell biology of its synthesis and of its physiological interactions. R J ReiterEndocr Rev19911649044No
145617761776.018.5218.5Chromatin structure: a repeating unit of histones and DNA. R D KornbergScience19744825889Yes
145735521776.082.6841.3The incidence of congenital heart disease. Julien I E Hoffman, Samuel KaplanJ Am Coll Cardiol200212084585No
145817741774.036.1636.2Protein homology detection by HMM-HMM comparison. Johannes SödingBioinformatics200515531603Yes
145917731773.036.2236.2An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. R M EsnoufJ Mol Graph Model19979385560Yes
146017721772.046.4346.4Chlorpromazine equivalent doses for the newer atypical antipsychotics. Scott W WoodsJ Clin Psychiatry200312823080No
1461124031771.9299.8442.8Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M NathanN Engl J Med200211832527Yes
146217711771.071.2371.2Whatever next? Predictive brains, situated agents, and the future of cognitive science. Andy ClarkBehav Brain Sci201323663408No
146317701770.058.6858.7Drugs of abuse: anatomy, pharmacology and function of reward pathways. G F KoobTrends Pharmacol Sci19921604710No
146435381769.0109.4754.7Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. F Denizot, R LangJ Immunol Methods19863486233Yes
146535371768.588.5544.3The biology of vascular endothelial growth factor. N Ferrara, T Davis-SmythEndocr Rev19979034784No
1466106091768.2318.2353.0New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier GascuelSyst Biol201020525638Yes
146717681768.0111.3111.3The Global Epidemic of the Metabolic Syndrome. Mohammad G SaklayenCurr Hypertens Rep201829480368No
146853031767.7223.2374.4The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Susan Michie, Maartje M van Stralen, Robert WestImplement Sci201121513547No
146935351767.5128.2864.1The integrative review: updated methodology. Robin Whittemore, Kathleen KnaflJ Adv Nurs200516268861Yes
147017671767.060.6660.7Falls in older people: epidemiology, risk factors and strategies for prevention. Laurence Z RubensteinAge Ageing200616926202No
147117661766.055.6255.6The stress response in fish. S E Wendelaar BongaPhysiol Rev19979234959No
147217661766.046.3546.4Oxidative stress and neurodegeneration: where are we now? Barry HalliwellJ Neurochem200616805774No
147317651765.00.00.0The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. S HestrinJ Biol Chem194918133390Yes
147417631763.039.0539.0Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. J N DumontJ Morphol19724109871Yes
1475176271762.7552.4355.2Measurement of protein using bicinchoninic acid. P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C KlenkAnal Biochem19853843705Yes
147635231761.573.3336.7Why do cancers have high aerobic glycolysis? Robert A Gatenby, Robert J GilliesNat Rev Cancer200415516961No
147788041760.8293.558.7The hallmarks of aging. Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido KroemerCell201323746838No
147817601760.046.7246.7Interleukin-6: an overview. J Van SnickAnnu Rev Immunol19902188664No
147935201760.074.7837.4Insulin signalling and the regulation of glucose and lipid metabolism. A R Saltiel, C R KahnNature200111742412Yes
148017601760.042.3942.4Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Paul M RidkerCirculation200312551853No
148117591759.051.0251.0Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. M J CasadabanJ Mol Biol1976781293Yes
148217591759.047.647.6G proteins and dual control of adenylate cyclase. A G GilmanCell19846321035Yes
148317581758.035.8235.8Oxidative stress shortens telomeres. Thomas von ZglinickiTrends Biochem Sci200212114022Yes
148417581758.00.00.0The recurrence of intracranial meningiomas after surgical treatment. D SimpsonJ Neurol Neurosurg Psychiatry195713406590Yes
148535151757.545.5422.8A complementation analysis of the restriction and modification of DNA in Escherichia coli. H W Boyer, D Roulland-DussoixJ Mol Biol19694896022Yes
148635141757.0157.3378.7The amyloid hypothesis of Alzheimer's disease at 25 years. Dennis J Selkoe, John HardyEMBO Mol Med201627025652No
148735121756.086.4643.2Matrix metalloproteinases. H Nagase, J F WoessnerJ Biol Chem199910419448No
148835121756.079.3539.7Shared principles in NF-kappaB signaling. Matthew S Hayden, Sankar GhoshCell200818267068No
148917541754.040.7640.8Areas, volumes, packing and protein structure. F M RichardsAnnu Rev Biophys Bioeng1977326146No
149017541754.00.00.0A personality scale of manifest anxiety. J A TaylorJ Abnorm Psychol195313052352Yes
149117531753.040.0640.1Steroid receptor regulated transcription of specific genes and gene networks. K R YamamotoAnnu Rev Genet19853909942No
149235061753.069.9635.0A guided tour into subcellular colocalization analysis in light microscopy. S Bolte, F P CordelièresJ Microsc200617210054Yes
149335051752.599.6549.8Alzheimer's disease. Henry W Querfurth, Frank M LaFerlaN Engl J Med201020107219No
149417511751.065.3865.4Simple proton spectroscopic imaging. W T DixonRadiology19846089263Yes
149517511751.061.0961.1The role of hormone receptors and GTP-regulatory proteins in membrane transduction. M RodbellNature19806101906Yes
149617511751.041.5941.6Tricine-SDS-PAGE. Hermann SchäggerNat Protoc200617406207Yes
149717501750.042.5542.5Why genes in pieces? W GilbertNature1978622185Yes
149817501750.043.6543.6Cellular basis of working memory. P S Goldman-RakicNeuron19957695894No
149917491749.047.1847.2Oxidative stress hypothesis in Alzheimer's disease. W R MarkesberyFree Radic Biol Med19979165306No
150034961748.092.6246.3Prediction of protein antigenic determinants from amino acid sequences. T P Hopp, K R WoodsProc Natl Acad Sci U S A19816167991Yes
150117481748.038.6338.6The synaptic vesicle cycle: a cascade of protein-protein interactions. T C SüdhofNature19957791897No
150234931746.582.841.4Origins and Mechanisms of miRNAs and siRNAs. Richard W Carthew, Erik J SontheimerCell200919239886No
150317461746.041.6941.7The relationship between the spleen colony-forming cell and the haemopoietic stem cell. R SchofieldBlood Cells1978747780Yes
150417461746.044.4344.4The pathophysiology of tumor necrosis factors. P VassalliAnnu Rev Immunol19921590993No
150534921746.069.1834.6An automated method for finding molecular complexes in large protein interaction networks. Gary D Bader, Christopher W V HogueBMC Bioinformatics200312525261Yes
150617461746.065.5765.6Antibiotics in the aquatic environment--a review--part I. Klaus KümmererChemosphere200919185900No
150734891744.5136.0368.0Assays of glutathione peroxidase. L Flohé, W A GünzlerMethods Enzymol19846727659Yes
150869731743.2293.8873.5An inventory for measuring clinical anxiety: psychometric properties. A T Beck, N Epstein, G Brown, R A SteerJ Consult Clin Psychol19883204199Yes
150917431743.037.7937.8ATPase activity of myosin correlated with speed of muscle shortening. M BárányJ Gen Physiol19674227924Yes
151017421742.052.6752.7Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. F RoussetGenetics19979093870Yes
151117421742.071.7771.8Adverse health effects of high-effort/low-reward conditions. J SiegristJ Occup Health Psychol19969547031No
151234841742.092.1846.1The mirror-neuron system. Giacomo Rizzolatti, Laila CraigheroAnnu Rev Neurosci200415217330No
151352251741.7118.0639.4Inflammation and atherosclerosis. Peter Libby, Paul M Ridker, Attilio MaseriCirculation200211877368No
151434821741.0139.2169.6Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. A Y Finlay, G K KhanClin Exp Dermatol19948033378Yes
151534821741.073.036.5Integrin signaling. F G Giancotti, E RuoslahtiScience199910446041No
151634811740.50.00.0Convergent and discriminant validation by the multitrait-multimethod matrix. D T Campbell, D W FiskePsychol Bull195913634291Yes
151717401740.032.8632.9Network motifs: theory and experimental approaches. Uri AlonNat Rev Genet200717510665No
151817401740.066.0566.0Selenium and human health. Margaret P RaymanLancet201222381456No
151969531738.2135.7733.9Transformation of intact yeast cells treated with alkali cations. H Ito, Y Fukuda, K Murata, A KimuraJ Bacteriol19836336730Yes
152034761738.0178.8189.4Interrater reliability of a modified Ashworth scale of muscle spasticity. R W Bohannon, M B SmithPhys Ther19873809245Yes
152117381738.056.3556.4Validation of a decisional conflict scale. A M O'ConnorMed Decis Making19957898294Yes
152234751737.5103.8151.9The pathogenesis of rheumatoid arthritis. Iain B McInnes, Georg SchettN Engl J Med201122150039No
152334731736.595.347.6Protective and pathogenic functions of macrophage subsets. Peter J Murray, Thomas A WynnNat Rev Immunol201121997792No
1524121551736.4406.9358.1GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J SchünemannBMJ200818436948Yes
152517361736.040.5640.6Solvent-accessible surfaces of proteins and nucleic acids. M L ConnollyScience19836879170Yes
152634691734.587.3243.7Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. S Schulman, C KearonJ Thromb Haemost200515842354Yes
152717341734.062.5462.5Cyclosporine. B D KahanN Engl J Med19892687689No
152817341734.054.3154.3Glutamate: a neurotransmitter in mammalian brain. F FonnumJ Neurochem19846139418No
152917331733.073.7673.8Dynamic properties of mammalian skeletal muscles. R I ClosePhysiol Rev19724256989No
153017331733.041.9942.0Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. Z YangJ Mol Evol19947932792Yes
153134651732.589.4344.7Regulation of chromatin by histone modifications. Andrew J Bannister, Tony KouzaridesCell Res201121321607No
153217321732.049.9650.0Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. E M WassermannElectroencephalogr Clin Neurophysiol19989474057No
153334631731.5149.4674.7A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. J G Snodgrass, M VanderwartJ Exp Psychol Hum Learn19807373248Yes
153451941731.3112.5837.5Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. A Nicholls, K A Sharp, B HonigProteins19911758883Yes
153534621731.094.1647.1Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. K B Mullis, F A FaloonaMethods Enzymol19873431465Yes
153617311731.056.8956.9Serum albumin. T PetersAdv Protein Chem19853904348No
153734621731.090.7445.4Cloned glutamate receptors. M Hollmann, S HeinemannAnnu Rev Neurosci19948210177No
153817311731.033.4633.5Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Judith CampisiCell200515734683No
153917301730.040.9240.9Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. A KrishanJ Cell Biol197549354Yes
154017291729.039.3239.3Mode of cell migration to the superficial layers of fetal monkey neocortex. P RakicJ Comp Neurol19724624784Yes
154117291729.059.4459.4Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? B HalliwellLancet19947915779No
154234571728.5132.7266.4The Emerging Hallmarks of Cancer Metabolism. Natalya N Pavlova, Craig B ThompsonCell Metab201626771115No
154351851728.3133.8744.6The rapid generation of mutation data matrices from protein sequences. D T Jones, W R Taylor, J M ThorntonComput Appl Biosci19921633570Yes
154417281728.037.437.4Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. A F HabeebAnal Biochem19664161471Yes
154517271727.061.0761.1Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. M Wong-RileyBrain Res1979223730Yes
154686301726.0196.7839.4Stages of embryonic development of the zebrafish. C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F SchillingDev Dyn19958589427Yes
154734521726.074.1837.1Fibroblasts in cancer. Raghu Kalluri, Michael ZeisbergNat Rev Cancer200616572188No
154817251725.056.1856.2The polyvagal perspective. Stephen W PorgesBiol Psychol200717049418No
154917241724.065.0765.1Modeling and variable selection in epidemiologic analysis. S GreenlandAm J Public Health19892916724Yes
155017231723.031.231.2CD4+ CD25+ suppressor T cells: more questions than answers. Ethan M ShevachNat Rev Immunol200212093005No
155117221722.058.6758.7Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. E M WitkinBacteriol Rev1976795416No
155234441722.0131.265.6The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. A J Stunkard, S MessickJ Psychosom Res19853981480Yes
155334441722.069.5234.8A general framework for weighted gene co-expression network analysis. Bin Zhang, Steve HorvathStat Appl Genet Mol Biol200516646834Yes
155417221722.038.7138.7Tumor angiogenesis. Robert S KerbelN Engl J Med200818463380No
155586071721.4324.5364.9UCHIME improves sensitivity and speed of chimera detection. Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob KnightBioinformatics201121700674Yes
155651621720.7231.3377.1Some statistical methods useful in circulation research. S Wallenstein, C L Zucker, J L FleissCirc Res19807379260Yes
155786021720.4212.4642.5Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan HsuN Engl J Med200415385656Yes
155817201720.037.6137.6AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. D Grahame HardieNat Rev Mol Cell Biol200717712357No
155917191719.037.0737.1Trastuzumab--mechanism of action and use in clinical practice. Clifford A HudisN Engl J Med200717611206No
156017181718.00.00.0Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. J SpizizenProc Natl Acad Sci U S A195816590310Yes
156134351717.586.6743.3Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. Steven E Nissen, Kathy WolskiN Engl J Med200717517853Yes
156217171717.045.5345.5THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. Kozi AsadaAnnu Rev Plant Physiol Plant Mol Biol199915012221Yes
156368661716.5225.7356.4Common method biases in behavioral research: a critical review of the literature and recommended remedies. Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P PodsakoffJ Appl Psychol200314516251No
156417161716.056.5656.6Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. C E MogensenN Engl J Med19846690964Yes
156551461715.3161.5753.9Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. H Esterbauer, R J Schaur, H ZollnerFree Radic Biol Med19911937131No
156617151715.056.7456.7Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. Lutz AckermannChem Rev201121391562Yes
156717141714.00.00.0The general adaptation syndrome and the diseases of adaptation. H SelyeJ Clin Endocrinol Metab194621025115Yes
156851411713.7134.4844.8A neural substrate of prediction and reward. W Schultz, P Dayan, P R MontagueScience19979054347No
156917121712.038.6138.6Effects of cytochalasin and phalloidin on actin. J A CooperJ Cell Biol19873312229No
157017121712.041.4241.4The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. R RossJ Cell Biol19714327464Yes
157117121712.059.959.9Computerized transverse axial scanning (tomography). 1. Description of system. G N HounsfieldBr J Radiol19734757352Yes
157217121712.044.5744.6Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. G C WalkerMicrobiol Rev19846371470No
1573136911711.4396.1349.5The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. Ziad S Nasreddine, Natalie A Phillips, Valérie Bédirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard ChertkowJ Am Geriatr Soc200515817019Yes
157417101710.033.5633.6The synaptic vesicle cycle. Thomas C SudhofAnnu Rev Neurosci200415217342No
157534191709.586.3343.2Quantum dot bioconjugates for ultrasensitive nonisotopic detection. W C Chan, S NieScience19989748158Yes
157634181709.0152.3176.2A fluorometric method for determination of oxidized and reduced glutathione in tissues. P J Hissin, R HilfAnal Biochem1976962076Yes
157734181709.082.5141.3The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. A E Bolton, W M HunterBiochem J19734733239Yes
157817091709.031.3331.3Transplacental carcinogenesis by stilbestrol. J FolkmanN Engl J Med19715556579Yes
157917091709.051.3151.3Constructions of masculinity and their influence on men's well-being: a theory of gender and health. W H CourtenaySoc Sci Med200010741575No
158017081708.032.7832.8Generating samples under a Wright-Fisher neutral model of genetic variation. Richard R HudsonBioinformatics200211847089Yes
158168311707.8196.2349.1The validity of the Hospital Anxiety and Depression Scale. An updated literature review. Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag NeckelmannJ Psychosom Res200211832252No
158217071707.031.3831.4How eukaryotic transcriptional activators work. M PtashneNature19883050531No
158317071707.068.168.1Sample size in qualitative research. M SandelowskiRes Nurs Health19957899572Yes
1584170591705.9541.0654.1The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S LuthraArthritis Rheum19883358796Yes
158534101705.0109.8854.9Separate visual pathways for perception and action. M A Goodale, A D MilnerTrends Neurosci19921374953No
158617051705.052.3752.4A measure of population subdivision based on microsatellite allele frequencies. M SlatkinGenetics19957705646Yes
158717051705.046.5146.5The origins of the developmental origins theory. D J P BarkerJ Intern Med200717444880No
158834101705.088.3644.2Multiple sclerosis. Alastair Compston, Alasdair ColesLancet200818970977Yes
158934091704.595.9448.0Astrocytes: biology and pathology. Michael V Sofroniew, Harry V VintersActa Neuropathol201020012068No
159068161704.0143.4135.9Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. E A Jaffe, R L Nachman, C G Becker, C R MinickJ Clin Invest19734355998Yes
159151121704.0112.2437.4An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J K Eng, A L McCormack, J R YatesJ Am Soc Mass Spectrom199424226387Yes
159234071703.5121.9561.0A "Direct-Coloring" Thiocholine Method For Cholinesterases. M J Karnovsky, L RootsJ Histochem Cytochem196414187330Yes
159317031703.075.2875.3The micronucleus test. W SchmidMutat Res197548190Yes
159417031703.068.5868.6Negative symptoms in schizophrenia. Definition and reliability. N C AndreasenArch Gen Psychiatry19827165477Yes
159551081702.7120.3540.1Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Prateek Kumar, Steven Henikoff, Pauline C NgNat Protoc200919561590Yes
159634051702.5159.7479.9Making sense of Cronbach's alpha. Mohsen Tavakol, Reg DennickInt J Med Educ201128029643No
159734031701.5102.6751.3The benefits of being present: mindfulness and its role in psychological well-being. Kirk Warren Brown, Richard M RyanJ Pers Soc Psychol200312703651Yes
159834031701.578.4439.2The BCL-2 protein family: opposing activities that mediate cell death. Richard J Youle, Andreas StrasserNat Rev Mol Cell Biol200818097445No
159951001700.0166.9355.6A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. J R Le Gall, S Lemeshow, F SaulnierJAMA19938254858Yes
160017001700.038.4138.4Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. S A BustinJ Mol Endocrinol200212200227No
160150991699.7153.2951.1Simultaneous inference in general parametric models. Torsten Hothorn, Frank Bretz, Peter WestfallBiom J200818481363No
160216991699.041.3741.4The statistical analysis of enzyme kinetic data. W W ClelandAdv Enzymol Relat Areas Mol Biol19674881884No
160316991699.039.6639.7Angiogenesis: an organizing principle for drug discovery? Judah FolkmanNat Rev Drug Discov200717396134No
160416981698.042.9242.9Carbonic anhydrase: chemistry, physiology, and inhibition. T H MarenPhysiol Rev19674964060No
160516981698.034.4734.5Neurotrophins and their receptors: a convergence point for many signalling pathways. Moses V ChaoNat Rev Neurosci200312671646No
1606101861697.7285.0647.5Positional cloning of the mouse obese gene and its human homologue. Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M FriedmanNature19947984236Yes
160716971697.069.769.7Responses to depression and their effects on the duration of depressive episodes. S Nolen-HoeksemaJ Abnorm Psychol19911757671No
160816951695.036.0836.1Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. S L FriedmanJ Biol Chem200010644669No
160933891694.593.6946.8Biochemistry of multidrug resistance mediated by the multidrug transporter. M M Gottesman, I PastanAnnu Rev Biochem19938102521No
161016941694.038.8438.8A graphic method for the determination and presentation of binding parameters in a complex system. H E RosenthalAnal Biochem19676048188Yes
161116931693.062.862.8Paced auditory serial-addition task: a measure of recovery from concussion. D M GronwallPercept Mot Skills1977866038Yes
161216931693.040.0340.0Two pathogenetic types of endometrial carcinoma. J V BokhmanGynecol Oncol19836822361Yes
161350771692.3182.9561.0Multiple imputation using chained equations: Issues and guidance for practice. Ian R White, Patrick Royston, Angela M WoodStat Med201121225900Yes
161416921692.036.6536.6The NCI60 human tumour cell line anticancer drug screen. Robert H ShoemakerNat Rev Cancer200616990858No
161533841692.0112.2156.1Neutrophil recruitment and function in health and inflammation. Elzbieta Kolaczkowska, Paul KubesNat Rev Immunol201323435331No
161633821691.0222.0111.0The structure of coping. L I Pearlin, C SchoolerJ Health Soc Behav1978649936Yes
161716911691.031.1331.1Cyclin-dependent kinases: engines, clocks, and microprocessors. D O MorganAnnu Rev Cell Dev Biol19979442875No
161833821691.080.9440.5CAP3: A DNA sequence assembly program. X Huang, A MadanGenome Res199910508846Yes
161916911691.068.9368.9Macrophage Polarization. Peter J MurrayAnnu Rev Physiol201727813830No
162016901690.045.2945.3Integrins. E RuoslahtiJ Clin Invest19911985087No
162116901690.051.7751.8Stress and disorders of the stress system. George P ChrousosNat Rev Endocrinol200919488073No
162267591689.8195.0748.8Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. B Biswal, F Z Yetkin, V M Haughton, J S HydeMagn Reson Med19958524021Yes
162316891689.054.754.7Synaptic density in human frontal cortex - developmental changes and effects of aging. P R HuttenlocherBrain Res1979427544Yes
162416881688.040.3140.3The molecular genetics of cancer. J M BishopScience19873541204No
162516881688.047.3847.4The in vitro micronucleus technique. M FenechMutat Res200011113469No
162616881688.038.8338.8PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. Michael F. ThomashowAnnu Rev Plant Physiol Plant Mol Biol199915012220Yes
162716881688.036.7936.8Perceptions of epigenetics. Adrian BirdNature200717522671Yes
162816871687.051.5351.5Pedigrees of some mutant strains of Escherichia coli K-12. B J BachmannBacteriol Rev19724568763No
162916861686.071.2871.3Plastic Embedding Mixtures For Use In Electron Microscopy. H H MollenhauerStain Technol196414127791Yes
163016861686.053.0553.0Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Joseph J VolpeLancet Neurol200919081519No
163116861686.018.1918.2Impulses and Physiological States in Theoretical Models of Nerve Membrane. R FitzhughBiophys J196119431309Yes
163233721686.0107.6853.8Neurocircuitry of addiction. George F Koob, Nora D VolkowNeuropsychopharmacology201019710631No
163350571685.7109.0536.4Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. J E Darnell, I M Kerr, G R StarkScience19948197455No
163433701685.098.9649.5An information-maximization approach to blind separation and blind deconvolution. A J Bell, T J SejnowskiNeural Comput19957584893Yes
163516851685.00.00.0The theory and applications of the exchange of inert gas at the lungs and tissues. S S KetyPharmacol Rev195114833874Yes
163616841684.039.1339.1A revolution in optical manipulation. David G GrierNature200312917694No
163733661683.0135.2267.6Methods for the thematic synthesis of qualitative research in systematic reviews. James Thomas, Angela HardenBMC Med Res Methodol200818616818Yes
163833661683.083.241.6Protein structure prediction on the Web: a case study using the Phyre server. Lawrence A Kelley, Michael J E SternbergNat Protoc200919247286Yes
163967301682.5265.3166.316S ribosomal DNA amplification for phylogenetic study. W G Weisburg, S M Barns, D A Pelletier, D J LaneJ Bacteriol19911987160Yes
164084101682.091.4118.3Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. S Katz, A B Ford, R W Moskowitz, B A Jackson, M W JaffeJAMA196314044222Yes
164116811681.044.6644.7Synergy, antagonism, and what the chequerboard puts between them. F C OddsJ Antimicrob Chemother200312805255No
164216811681.00.00.0Note on the sampling error of the difference between correlated proportions or percentages. Q McNEMARPsychometrika194720254758Yes
164367241681.0223.1255.8SignalP 4.0: discriminating signal peptides from transmembrane regions. Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik NielsenNat Methods201121959131Yes
164433611680.569.7634.9A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. D Wessel, U I FlüggeAnal Biochem19846731838Yes
164533611680.583.441.7Receptors for purines and pyrimidines. V Ralevic, G BurnstockPharmacol Rev19989755289No
164633601680.0125.2262.6The mini-mental state examination: a comprehensive review. T N Tombaugh, N J McIntyreJ Am Geriatr Soc19921512391No
164733591679.591.0445.5Bronchopulmonary dysplasia. A H Jobe, E BancalariAm J Respir Crit Care Med200111401896No
164816791679.014.0814.1Chromatographic Separation Of Human Brain Gangliosides. L SvennerholmJ Neurochem196314066623Yes
164933571678.571.4235.7The epigenomics of cancer. Peter A Jones, Stephen B BaylinCell200717320506No
165016781678.060.9761.0Modeling Development and Disease with Organoids. Hans CleversCell201627315476No
165116771677.049.2149.2Drugs which inhibit prostaglandin biosynthesis. R J FlowerPharmacol Rev19744208101Yes
165216771677.038.5638.6NADPH oxidase: an update. B M BabiorBlood199910029572No
165333531676.578.5539.3Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Robert Visse, Hideaki NagaseCirc Res200312730128No
165416761676.058.3758.4Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. A H ConneyCancer Res19826814745No
165516761676.032.8232.8Hox genes in vertebrate development. R KrumlaufCell19947913880No
165633521676.092.3246.2A perspective on cancer cell metastasis. Christine L Chaffer, Robert A WeinbergScience201121436443No
165716751675.031.0531.1Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. M G GustafssonJ Microsc200010810003Yes
165833481674.0110.3155.2Role of free radicals and catalytic metal ions in human disease: an overview. B Halliwell, J M GutteridgeMethods Enzymol19902172697No
165966951673.8205.2551.3The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. S P Baker, B O'Neill, W Haddon, W B LongJ Trauma19744814394Yes
166033471673.579.1539.6The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. P Angel, M KarinBiochim Biophys Acta19911751545No
166116731673.045.0645.1Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. J A MillerCancer Res19704915745No
166216731673.038.3738.4The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. D M KingsleyGenes Dev19948299934No
166316721672.081.5581.5Hydrogel: Preparation, characterization, and applications: A review. Enas M AhmedJ Adv Res201525750745No
166416711671.059.5559.5Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). G G GlennerN Engl J Med19806154243No
166516711671.030.8330.8Neuroblastoma: biological insights into a clinical enigma. Garrett M BrodeurNat Rev Cancer200312612655No
166616711671.039.6239.6The failing heart--an engine out of fuel. Stefan NeubauerN Engl J Med200717360992No
166716701670.050.0250.0Stress signalling pathways that impair prefrontal cortex structure and function. Amy F T ArnstenNat Rev Neurosci200919455173No
1668100171669.5204.4734.1Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C MelloNature19989486653Yes
166933391669.553.8226.9Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. J Marmur, P DotyJ Mol Biol196214470099Yes
167016691669.046.8246.8Semiempirical hybrid density functional with perturbative second-order correlation. Stefan GrimmeJ Chem Phys200616438568Yes
167116691669.046.8946.9The many roles for fluorine in medicinal chemistry. William K HagmannJ Med Chem200818570365Yes
167250061668.7263.4587.8Impact of Event Scale: a measure of subjective stress. M Horowitz, N Wilner, W AlvarezPsychosom Med1979472086Yes
167316681668.053.5253.5The global impact of pre-eclampsia and eclampsia. Lelia DuleySemin Perinatol200919464502No
167450021667.3197.5465.8The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. C A McHorney, J E Ware, A E RaczekMed Care19938450681Yes
167516671667.063.8863.9Probiotics in man and animals. R FullerJ Appl Bacteriol19892666378No
167616671667.019.9119.9Amino acid difference formula to help explain protein evolution. R GranthamScience19744843792Yes
167716671667.054.9254.9Number of people with glaucoma worldwide. H A QuigleyBr J Ophthalmol19968695555No
167816671667.042.6442.6Understanding biofilm resistance to antibacterial agents. David DaviesNat Rev Drug Discov200312563302No
167916671667.00.00.0Method for the determination of hexosamines in tissues. N F BoasJ Biol Chem195313117829Yes
168016671667.037.1437.1Introduction to NF-kappaB: players, pathways, perspectives. T D GilmoreOncogene200617072321No
168116661666.082.1782.2Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. K O FagerströmAddict Behav1978735910Yes
168216661666.040.8940.9Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Shitij KapurAm J Psychiatry200312505794No
168316661666.00.00.0Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. E G GrayJ Anat195913829103Yes
168416661666.035.935.9Hematopoietic stem-cell transplantation. Edward A CopelanN Engl J Med200616641398No
168533301665.0127.2963.6A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. J A Horne, O OstbergInt J Chronobiol19761027738Yes
168616651665.032.3332.3Cell cycle checkpoints: preventing an identity crisis. S J ElledgeScience19968939848No
168716641664.052.6552.6Metallothionein. D H HamerAnnu Rev Biochem19863527054No
168816641664.046.0646.1Multiple imputation of discrete and continuous data by fully conditional specification. Stef van BuurenStat Methods Med Res200717621469Yes
168916631663.039.739.7Inflammatory bowel disease: etiology and pathogenesis. C FiocchiGastroenterology19989649475No
169016621662.039.0939.1Five rules for the evolution of cooperation. Martin A NowakScience200617158317No
169116621662.057.9257.9Cytokines in inflammatory bowel disease. Markus F NeurathNat Rev Immunol201424751956No
1692116311661.6344.449.2AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J OlsonJ Comput Chem200919399780Yes
169316611661.067.7367.7A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. D J SchuirmannJ Pharmacokinet Biopharm19873450848Yes
169433221661.069.1234.6Fitting a mixture model by expectation maximization to discover motifs in biopolymers. T L Bailey, C ElkanProc Int Conf Intell Syst Mol Biol19947584402Yes
169533211660.5215.69107.8A clinical method of functional assessment of the shoulder. C R Constant, A H MurleyClin Orthop Relat Res19873791738Yes
169616601660.031.631.6Simple memory: a theory for archicortex. D MarrPhilos Trans R Soc Lond B Biol Sci19714399412Yes
169716601660.050.4450.4Apoptosis in cancer: from pathogenesis to treatment. Rebecca S Y WongJ Exp Clin Cancer Res201121943236No
169816581658.059.4959.5Dual-task interference in simple tasks: data and theory. H PashlerPsychol Bull19947972591No
169916581658.046.9747.0Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. James J P StewartJ Mol Model200717828561Yes
170016581658.046.1246.1Understanding organofluorine chemistry. An introduction to the C-F bond. David O'HaganChem Soc Rev200818197347No
170116571657.044.4244.4An improved procedure for serum creatine phosphokinase determination. S B RosalkiJ Lab Clin Med19674381359Yes
170216571657.035.7135.7An approximately unbiased test of phylogenetic tree selection. Hidetoshi ShimodairaSyst Biol200212079646Yes
170316571657.042.0342.0The importance of the ratio of omega-6/omega-3 essential fatty acids. A P SimopoulosBiomed Pharmacother200212442909No
170433131656.583.6141.8Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. M Grunstein, D S HognessProc Natl Acad Sci U S A19751105573Yes
170516561656.031.2431.2Switching and signaling at the telomere. E H BlackburnCell200111572773No
170616561656.033.3833.4DNA in a material world. Nadrian C SeemanNature200312540916No
170733121656.078.1139.1Adipose tissue as an endocrine organ. Erin E Kershaw, Jeffrey S FlierJ Clin Endocrinol Metab200415181022No
170816551655.023.7923.8RNA-dependent DNA polymerase in virions of RNA tumour viruses. D BaltimoreNature19704316300Yes
170933101655.058.829.4Method for the isolation of intact islets of Langerhans from the rat pancreas. P E Lacy, M KostianovskyDiabetes19675333500Yes
171033091654.5131.5765.8The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. T Omura, R SatoJ Biol Chem196414209972Yes
171133071653.566.6733.3Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Gary L Johnson, Razvan LapadatScience200212471242No
171266121653.0152.4738.1Use of T7 RNA polymerase to direct expression of cloned genes. F W Studier, A H Rosenberg, J J Dunn, J W DubendorffMethods Enzymol19902199796Yes
171333061653.0137.4768.7Parkinson's disease. Lorraine V Kalia, Anthony E LangLancet201525904081No
171433031651.566.3133.2Upstream and downstream of mTOR. Nissim Hay, Nahum SonenbergGenes Dev200415314020No
171516501650.041.7641.8Neurotrophins and neuronal plasticity. H ThoenenScience19957570017No
171616501650.0127.1127.1User's guide to correlation coefficients. Haldun AkogluTurk J Emerg Med201830191186No
171716481648.037.5637.6In vivo near-infrared fluorescence imaging. John V FrangioniCurr Opin Chem Biol200314580568No
171832961648.075.1337.6Human mesenchymal stem cells modulate allogeneic immune cell responses. Sudeepta Aggarwal, Mark F PittengerBlood200515494428Yes
171916471647.042.7442.7Alpha-crystallin can function as a molecular chaperone. J HorwitzProc Natl Acad Sci U S A19921438232Yes
172016461646.073.4573.5The structure and properties of the sense of coherence scale. A AntonovskySoc Sci Med19938480217Yes
172132921646.083.5141.8ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. Markus Wiederstein, Manfred J SipplNucleic Acids Res200717517781Yes
172265821645.5287.3571.8A rating scale for mania: reliability, validity and sensitivity. R C Young, J T Biggs, V E Ziegler, D A MeyerBr J Psychiatry1978728692Yes
172332911645.585.7342.9Early identification of refractory epilepsy. P Kwan, M J BrodieN Engl J Med200010660394Yes
172432911645.586.5243.3Molecular mechanisms of long noncoding RNAs. Kevin C Wang, Howard Y ChangMol Cell201121925379No
172516441644.046.8646.9The basal ganglia: focused selection and inhibition of competing motor programs. J W MinkProg Neurobiol19969004351No
172616441644.049.9249.9Chlorophyll fluorescence: a probe of photosynthesis in vivo. Neil R BakerAnnu Rev Plant Biol200818444897No
172732871643.5155.3377.7Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. Ivica Letunic, Peer BorkNucleic Acids Res201627095192Yes
172816431643.054.0154.0Archaea in coastal marine environments. E F DeLongProc Natl Acad Sci U S A19921608980Yes
172916431643.048.7648.8Extracellular ATP: effects, sources and fate. J L GordonBiochem J19863006665No
173016431643.034.8434.8Neuronal calcium signaling. M J BerridgeNeuron19989697848No
173132851642.571.2235.6Protein structure comparison by alignment of distance matrices. L Holm, C SanderJ Mol Biol19938377180Yes
173216421642.0202.98203.0COVID-19 and mental health: A review of the existing literature. Ravi Philip RajkumarAsian J Psychiatr202032302935Yes
173398471641.2227.7538.0Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuireScience19873798106Yes
173416411641.048.4948.5Classification of inflammatory bowel disease. J E Lennard-JonesScand J Gastroenterol Suppl19892617184Yes
173516411641.058.058.0The linear-quadratic formula and progress in fractionated radiotherapy. J F FowlerBr J Radiol19892670032No
173616411641.045.345.3Turnover of inositol phospholipids and signal transduction. Y NishizukaScience19846147898No
173716401640.056.8656.9The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. E J KhantzianHarv Rev Psychiatry19979385000No
1738180371639.7565.3151.4A new equation to estimate glomerular filtration rate. Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef CoreshAnn Intern Med200919414839Yes
173932791639.5116.8958.4Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. M M Bradley, P J LangJ Behav Ther Exp Psychiatry19947962581Yes
174016381638.072.872.8Mood and memory. G H BowerAm Psychol19817224324Yes
174132731636.563.1431.6The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. J O'Keefe, J DostrovskyBrain Res19715124915Yes
174249081636.0116.438.8Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck ØrntoftCancer Res200415289330Yes
174316351635.056.5856.6Frontal-subcortical circuits and human behavior. J L CummingsArch Neurol19938352676No
174416351635.029.1429.1Maximum-likelihood density modification. T C TerwilligerActa Crystallogr D Biol Crystallogr200010944333Yes
174532671633.567.9634.0The Ki-67 protein: from the known and the unknown. T Scholzen, J GerdesJ Cell Physiol200010653597No
174616311631.040.5540.5A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. D MattinglyJ Clin Pathol196214471419Yes
174716301630.033.1833.2Structural features in eukaryotic mRNAs that modulate the initiation of translation. M KozakJ Biol Chem19911939050No
174816301630.057.257.2The case-crossover design: a method for studying transient effects on the risk of acute events. M MaclureAm J Epidemiol19911985444Yes
174916291629.071.071.0Neurogenetic adaptive mechanisms in alcoholism. C R CloningerScience19872882604Yes
175016291629.058.4558.5Aging, natural death, and the compression of morbidity. J F FriesN Engl J Med19807383070Yes
175116291629.034.6934.7Bone morphogenetic proteins: multifunctional regulators of vertebrate development. B L HoganGenes Dev19968682290No
175216291629.040.0640.1Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. M J MeaneyAnnu Rev Neurosci200111520931No
175348851628.395.1331.7T-Coffee: A novel method for fast and accurate multiple sequence alignment. C Notredame, D G Higgins, J HeringaJ Mol Biol200010964570Yes
175416281628.040.7940.8External validity of randomised controlled trials: "to whom do the results of this trial apply?". Peter M RothwellLancet200515639683Yes
175516281628.053.2653.3The role of senescent cells in ageing. Jan M van DeursenNature201424848057No
175616271627.042.5842.6Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. D A DoughertyScience19968539615No
175716271627.042.4642.5Task switching. Stephen MonsellTrends Cogn Sci200312639695Yes
175816261626.058.0658.1Cell damage in the brain: a speculative synthesis. B K SiesjöJ Cereb Blood Flow Metab19816276420No
175997521625.3338.256.4Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R TannenbaumAnal Biochem19827181105Yes
176016251625.045.445.4Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. B HilleJ Gen Physiol1977300786Yes
176116241624.050.8650.9Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. D W ChoiTrends Neurosci19882469166No
176216241624.022.8622.9Structural considerations in the interaction of DNA and acridines. L S LermanJ Mol Biol196113761054Yes
176316241624.066.6966.7Structure, Function, and Evolution of Coronavirus Spike Proteins. Fang LiAnnu Rev Virol201627578435No
176416241624.076.4576.5Neutrophil extracellular traps in immunity and disease. Venizelos PapayannopoulosNat Rev Immunol201828990587No
176516231623.036.9837.0Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. S C ManolagasEndocr Rev200010782361No
176616221622.046.5146.5Fluorescence energy transfer as a spectroscopic ruler. L StryerAnnu Rev Biochem1978354506No
176732391619.589.0844.5Diarrheagenic Escherichia coli. J P Nataro, J B KaperClin Microbiol Rev19989457432No
176816191619.054.6954.7Interhemispheric differences in the localization of psychological processes in man. B MilnerBr Med Bull19714937273No
176916191619.049.1249.1Ordinary magic. Resilience processes in development. A S MastenAm Psychol200111315249Yes
177016191619.053.053.0Asthma phenotypes: the evolution from clinical to molecular approaches. Sally E WenzelNat Med201222561835No
177132371618.576.7938.4Rapid and sensitive protein similarity searches. D J Lipman, W R PearsonScience19852983426Yes
177216181618.047.5847.6Metalloproteinases and their inhibitors in matrix remodeling. L M MatrisianTrends Genet19902132731No
177316181618.049.4449.4Efficient analysis of experimental observations. W J DixonAnnu Rev Pharmacol Toxicol19807387124Yes
177416181618.030.2130.2Germinal centers. I C MacLennanAnnu Rev Immunol19948011279No
177532331616.596.3548.2Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. M Karas, F HillenkampAnal Chem19883239801Yes
177616161616.027.5427.5Cell cycle checkpoint signaling through the ATM and ATR kinases. R T AbrahamGenes Dev200111544175No
177716161616.030.530.5Protein kinases--the major drug targets of the twenty-first century? Philip CohenNat Rev Drug Discov200212120282No
177816151615.039.9840.0Marine viruses--major players in the global ecosystem. Curtis A SuttleNat Rev Microbiol200717853907No
177916131613.039.4339.4Recognition of errors in three-dimensional structures of proteins. M J SipplProteins19938108378Yes
178016121612.045.6245.6Ionic dependence of glutamate neurotoxicity. D W ChoiJ Neurosci19872880938Yes
178116121612.033.9133.9The caveolae membrane system. R G AndersonAnnu Rev Biochem19989759488No
178216121612.036.9436.9Neurovascular regulation in the normal brain and in Alzheimer's disease. Costantino IadecolaNat Rev Neurosci200415100718No
178316111611.040.5340.5The genetical evolution of social behaviour. II. W D HamiltonJ Theor Biol19645875340Yes
178432221611.0172.086.0Natural Products as Sources of New Drugs from 1981 to 2014. David J Newman, Gordon M CraggJ Nat Prod201626852623No
178516101610.052.3652.4Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). M N MarshGastroenterology19921727768No
178616101610.00.00.0Cerebral blood flow and oxygen consumption in man. N A LassenPhysiol Rev195913645234Yes
178748301610.0101.8233.9Adjusting batch effects in microarray expression data using empirical Bayes methods. W Evan Johnson, Cheng Li, Ariel RabinovicBiostatistics200716632515Yes
178816091609.00.00.0Application of a Theory of Enzyme Specificity to Protein Synthesis. D E KoshlandProc Natl Acad Sci U S A195816590179Yes
178916071607.074.9875.0Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. Kevin A HallgrenTutor Quant Methods Psychol201222833776Yes
179032141607.098.2549.1How good are my data and what is the resolution? Philip R Evans, Garib N MurshudovActa Crystallogr D Biol Crystallogr201323793146Yes
179132131606.597.9649.0Oxidative stress and diabetic complications. Ferdinando Giacco, Michael BrownleeCirc Res201021030723No
179216061606.051.1151.1Cellular defenses against damage from reactive oxygen species. B P YuPhysiol Rev19948295932No
179316061606.031.5631.6Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. D I SvergunBiophys J199910354416Yes
179416061606.037.9337.9The blood-brain barrier: bottleneck in brain drug development. William M PardridgeNeuroRx200515717053No
179532101605.094.3247.2Unified approach for molecular dynamics and density-functional theory. R Car, M ParrinelloPhys Rev Lett198510032153Yes
179616051605.036.6636.7Getting formal with dopamine and reward. Wolfram SchultzNeuron200212383780No
179716051605.030.8830.9The microRNA Registry. Sam Griffiths-JonesNucleic Acids Res200414681370Yes
179832101605.0100.7150.4Neoantigens in cancer immunotherapy. Ton N Schumacher, Robert D SchreiberScience201525838375No
179932091604.562.1331.1Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. M E Greenberg, E B ZiffNature19846090941Yes
180016031603.044.2344.2Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. P A BradfordClin Microbiol Rev200111585791No
180132061603.066.2433.1Signaling to NF-kappaB. Matthew S Hayden, Sankar GhoshGenes Dev200415371334No
180216031603.045.0645.1Gold-catalyzed organic reactions. A Stephen K HashmiChem Rev200717580975Yes
180316021602.056.0456.0Multimodal approach to control postoperative pathophysiology and rehabilitation. H KehletBr J Anaesth19979175983No
180432041602.0124.6762.3Alginate: properties and biomedical applications. Kuen Yong Lee, David J MooneyProg Polym Sci201222125349Yes
180532031601.5113.3556.7Avoiding false positives with PCR. S Kwok, R HiguchiNature19892716852Yes
180616011601.036.8436.8VLA proteins in the integrin family: structures, functions, and their role on leukocytes. M E HemlerAnnu Rev Immunol19902188667No
180716011601.072.5872.6Measurement of health state utilities for economic appraisal. G W TorranceJ Health Econ198610311607No
180816011601.039.0939.1The corticosteroid receptor hypothesis of depression. F HolsboerNeuropsychopharmacology200011027914No
180916011601.047.2847.3A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Ozcan ErelClin Biochem200415003729Yes
181032011600.561.7630.9Automated MAD and MIR structure solution. T C Terwilliger, J BerendzenActa Crystallogr D Biol Crystallogr199910089316Yes
181132001600.083.2641.6Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. D B Dill, D L CostillJ Appl Physiol19744850854Yes
181216001600.00.00.0Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. O OuchterlonyActa Pathol Microbiol Scand195313079779Yes
181315991599.036.2136.2Cellular oncogenes and retroviruses. J M BishopAnnu Rev Biochem19836351725No
181415991599.042.2242.2Precision mapping of quantitative trait loci. Z B ZengGenetics19948013918Yes
181515991599.036.9937.0A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. D A GewirtzBiochem Pharmacol199910075079No
181615991599.035.8535.9Hypertrophic cardiomyopathy: a systematic review. Barry J MaronJAMA200211886323No
181715981598.034.4134.4On finding all suboptimal foldings of an RNA molecule. M ZukerScience19892468181No
181815981598.030.8230.8The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. A G PearseJ Histochem Cytochem19694143745No
181931961598.071.0935.5Lipopolysaccharide endotoxins. Christian R H Raetz, Chris WhitfieldAnnu Rev Biochem200212045108No
182031951597.562.2331.1The evolutionary fate and consequences of duplicate genes. M Lynch, J S ConeryScience200011073452No
182131951597.5102.8851.4The future of immune checkpoint therapy. Padmanee Sharma, James P AllisonScience201525838373No
182215971597.040.8640.9Molecular biology of prion diseases. S B PrusinerScience19911675487No
182315971597.045.7245.7The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. R R LlinásScience19883059497No
182415961596.031.5131.5An analysis of vertebrate mRNA sequences: intimations of translational control. M KozakJ Cell Biol19911955461No
182515961596.071.2671.3The contribution of low birth weight to infant mortality and childhood morbidity. M C McCormickN Engl J Med19853880598No
182631921596.067.5133.8Inhibitors of mammalian G1 cyclin-dependent kinases. C J Sherr, J M RobertsGenes Dev19957758941No
182731911595.589.244.6Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Sally S Dickerson, Margaret E KemenyPsychol Bull200415122924Yes
182815951595.057.2857.3Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. P HolzerPharmacol Rev19911852779No
182915951595.028.8328.8Altering the genome by homologous recombination. M R CapecchiScience19892660260No
183015951595.047.9648.0Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. L BravoNutr Rev19989838798No
183115951595.036.836.8Insulin and insulin-like growth factor signalling in neoplasia. Michael PollakNat Rev Cancer200819029956No
183263771594.2216.7254.2Guidelines for the process of cross-cultural adaptation of self-report measures. D E Beaton, C Bombardier, F Guillemin, M B FerrazSpine (Phila Pa 1976)200011124735No
183315931593.039.339.3Tumor necrosis factor (TNF). L J OldScience19852413547Yes
183431861593.077.638.8A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. S Tabor, C C RichardsonProc Natl Acad Sci U S A19853156376Yes
183531861593.087.944.0Polyamines. C W Tabor, H TaborAnnu Rev Biochem19846206782No
183631851592.599.8249.9Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. G R Gibson, M B RoberfroidJ Nutr19957782892No
183715921592.035.8935.9Thiazolidinediones. Hannele Yki-JärvinenN Engl J Med200415356308No
183831831591.562.5331.3NF-kappaB regulation in the immune system. Qiutang Li, Inder M VermaNat Rev Immunol200212360211No
183931831591.565.2132.6Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. E Krissinel, K HenrickActa Crystallogr D Biol Crystallogr200415572779Yes
184015911591.048.8648.9The role of the amygdala in fear and anxiety. M DavisAnnu Rev Neurosci19921575447No
184131821591.065.1532.6'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? George Davey Smith, Shah EbrahimInt J Epidemiol200312689998No
184231821591.076.3738.2Cell signaling by receptor tyrosine kinases. Mark A Lemmon, Joseph SchlessingerCell201020602996No
184315911591.077.5377.5International classification of sleep disorders-third edition: highlights and modifications. Michael J SateiaChest201425367475No
184431811590.569.0434.5Neurotrophins: roles in neuronal development and function. E J Huang, L F ReichardtAnnu Rev Neurosci200111520916No
184515901590.040.4940.5Aspergillus fumigatus and aspergillosis. J P LatgéClin Microbiol Rev199910194462No
184615901590.063.5163.5Nonalcoholic fatty liver disease: a systematic review. Mary E RinellaJAMA201526057287No
184731781589.091.4445.7Oxidative stress, glutamate, and neurodegenerative disorders. J T Coyle, P PuttfarckenScience19937901908No
184815881588.079.779.7Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. F E ZajacCrit Rev Biomed Eng19892676342No
184947641588.0130.3343.4Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. M Hasegawa, H Kishino, T YanoJ Mol Evol19853934395Yes
185047641588.0115.9738.7Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. Earl S Ford, Wayne H Giles, William H DietzJAMA200211790215Yes
185115881588.034.2434.2Mechanisms of bone metastasis. G David RoodmanN Engl J Med200415084698No
185247621587.3277.0592.4SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Antoine Daina, Olivier Michielin, Vincent ZoeteSci Rep201728256516Yes
185315871587.041.9742.0A more meaningful scoring system for determining the severity of coronary heart disease. G G GensiniAm J Cardiol19836823874Yes
185415871587.034.4234.4Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. G L SemenzaAnnu Rev Cell Dev Biol199910611972No
185515871587.035.6535.6The Unified Medical Language System (UMLS): integrating biomedical terminology. Olivier BodenreiderNucleic Acids Res200414681409Yes
185631721586.092.4646.2Density functionals with broad applicability in chemistry. Yan Zhao, Donald G TruhlarAcc Chem Res200818186612Yes
185715861586.062.6662.7α-band oscillations, attention, and controlled access to stored information. Wolfgang KlimeschTrends Cogn Sci201223141428No
185815851585.052.3252.3Which elements are excited in electrical stimulation of mammalian central nervous system: a review. J B RanckBrain Res19751102064No
185915851585.031.1131.1Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. R K JainNat Med200111533692No
186015851585.00.00.0Discharge patterns and functional organization of mammalian retina. S W KufflerJ Neurophysiol195313035466Yes
186115841584.048.1548.1Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. W H OldendorfAm J Physiol19715124307Yes
186247511583.7115.8638.6Two-photon laser scanning fluorescence microscopy. W Denk, J H Strickler, W W WebbScience19902321027Yes
186315831583.030.4130.4Regulatory T cells, tumour immunity and immunotherapy. Weiping ZouNat Rev Immunol200616557261No
186494951582.5223.6837.3GROMACS: fast, flexible, and free. David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C BerendsenJ Comput Chem200516211538Yes
186515821582.0110.4110.4Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. C S NeerJ Bone Joint Surg Am19725054450Yes
186631641582.075.1237.6Unravelling the pathogenesis of inflammatory bowel disease. R J Xavier, D K PodolskyNature200717653185No
186731631581.596.8348.4Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. D S Bredt, S H SnyderProc Natl Acad Sci U S A19901689048Yes
186831601580.058.0729.0The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Michael H Glickman, Aaron CiechanoverPhysiol Rev200211917093No
186915801580.052.1152.1Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. Virginia A MoyerAnn Intern Med201222801674No
187031591579.599.2649.6Palladium-catalyzed ligand-directed C-H functionalization reactions. Thomas W Lyons, Melanie S SanfordChem Rev201020078038No
187115791579.029.3729.4How cells read TGF-beta signals. J MassaguéNat Rev Mol Cell Biol200011252892No
187215791579.048.3648.4Dithiothreitol, A New Protective Reagent For Sh Groups. W W ClelandBiochemistry196414192894Yes
187315781578.029.7529.8Intrinsically unstructured proteins. Peter TompaTrends Biochem Sci200212368089No
187415781578.029.8629.9Immunosuppressive networks in the tumour environment and their therapeutic relevance. Weiping ZouNat Rev Cancer200515776005No
187515771577.035.4435.4The proto-oncogene Bcl-2 and its role in regulating apoptosis. G KroemerNat Med19979176486No
187663011575.2154.5338.6Most mammalian mRNAs are conserved targets of microRNAs. Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P BartelGenome Res200918955434Yes
187715751575.052.6652.7Biology of interleukin 1. C A DinarelloFASEB J19883277884No
187815751575.042.6842.7The complete general secretory pathway in gram-negative bacteria. A P PugsleyMicrobiol Rev19938096622No
187915751575.037.3337.3The biology of incretin hormones. Daniel J DruckerCell Metab200616517403No
188047251575.0121.7940.6Optimization by simulated annealing. S Kirkpatrick, C D Gelatt, M P VecchiScience198317813860Yes
188131491574.568.1334.1Microtubules as a target for anticancer drugs. Mary Ann Jordan, Leslie WilsonNat Rev Cancer200415057285No
188215741574.065.0965.1Regulation of noradrenaline release by presynaptic receptor systems. K StarkeRev Physiol Biochem Pharmacol197714389No
188315741574.033.4533.5Tumor metastasis: mechanistic insights and clinical challenges. Patricia S SteegNat Med200616892035No
188415741574.035.8935.9Neurotrophin-regulated signalling pathways. Louis F ReichardtPhilos Trans R Soc Lond B Biol Sci200616939974No
188515741574.037.9237.9Clinical features of metastatic bone disease and risk of skeletal morbidity. Robert E ColemanClin Cancer Res200617062708No
188631481574.067.1533.6Cancer metastasis: building a framework. Gaorav P Gupta, Joan MassaguéCell200617110329No
188715741574.059.359.3A Protection Motivation Theory of Fear Appeals and Attitude Change1. Ronald W RogersJ Psychol197528136248Yes
188815731573.033.4833.5From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. W A CatterallNeuron200010798388No
188915721572.041.6541.6Molecular bases of the acute coronary syndromes. P LibbyCirculation19957758192No
189031441572.070.2235.1The human plasma proteome: history, character, and diagnostic prospects. N Leigh Anderson, Norman G AndersonMol Cell Proteomics200212488461No
189115721572.00.00.0Cerebral vascular accidents in patients over the age of 60. II. Prognosis. J RankinScott Med J195713432835Yes
189215721572.029.8229.8Protein degradation and protection against misfolded or damaged proteins. Alfred L GoldbergNature200314685250No
189331441572.067.1733.6Complex networks orchestrate epithelial-mesenchymal transitions. Jean Paul Thiery, Jonathan P SleemanNat Rev Mol Cell Biol200616493418No
189431431571.593.2846.6Quality control and preprocessing of metagenomic datasets. Robert Schmieder, Robert EdwardsBioinformatics201121278185Yes
189531431571.5140.1770.1MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Rajesha Rupaimoole, Frank J SlackNat Rev Drug Discov201728209991No
189631411570.5116.9458.5Universal chemical assay for the detection and determination of siderophores. B Schwyn, J B NeilandsAnal Biochem19872952030Yes
189715701570.044.7844.8Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. S HakomoriAnnu Rev Biochem19817023369No
189815701570.037.6637.7HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. J M CoffinScience19957824947Yes
189915701570.026.0426.0Neuronal specification in the spinal cord: inductive signals and transcriptional codes. T M JessellNat Rev Genet200011262869No
190031391569.5109.7754.9The M1 and M2 paradigm of macrophage activation: time for reassessment. Fernando O Martinez, Siamon GordonF1000Prime Rep201424669294No
190115691569.059.459.4Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. P HolzerNeuroscience19883288903No
190294141569.0265.9244.3A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle CharpentierScience201222745249Yes
190331371568.5101.1250.6The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. R Doll, R PetoJ Natl Cancer Inst19817017215No
190431361568.060.4530.2Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. O Tetsu, F McCormickNature199910201372Yes
190515681568.00.00.0A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. B C HummelCan J Biochem Physiol195914405350Yes
190615671567.027.6927.7Selforganization of matter and the evolution of biological macromolecules. M EigenNaturwissenschaften19714942363No
190731341567.073.9737.0Malignant gliomas in adults. Patrick Y Wen, Santosh KesariN Engl J Med200818669428No
190831331566.566.2433.1Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. C B Lozzio, B B LozzioBlood1975163658Yes
190915661566.031.1831.2The Buccaneer software for automated model building. 1. Tracing protein chains. Kevin CowtanActa Crystallogr D Biol Crystallogr200616929101Yes
191031311565.575.7937.9Steatohepatitis: a tale of two "hits"? C P Day, O F JamesGastroenterology19989547102No
191131311565.590.8945.4Extended-connectivity fingerprints. David Rogers, Mathew HahnJ Chem Inf Model201020426451Yes
191246951565.087.5329.2Notch signaling: cell fate control and signal integration in development. S Artavanis-Tsakonas, M D Rand, R J LakeScience199910221902No
191331301565.079.2139.6Dali server: conservation mapping in 3D. Liisa Holm, Päivi RosenströmNucleic Acids Res201020457744Yes
191446861562.092.8330.9Efficient selection for high-expression transfectants with a novel eukaryotic vector. H Niwa, K Yamamura, J MiyazakiGene19911660837Yes
191515621562.045.9746.0The glomerular permeability determined by dextran clearance using Sephadex gel filtration. C E MogensenScand J Clin Lab Invest19685637478Yes
191615621562.048.3348.3The law of attrition. Gunther EysenbachJ Med Internet Res200515829473Yes
191731211560.566.6333.3Self-assembly at all scales. George M Whitesides, Bartosz GrzybowskiScience200211923529Yes
191815601560.00.00.0The estimation of phosphorus. R J AllenBiochem J194016747230Yes
191946791559.7104.7134.9Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Hartmuth C. Kolb, M G Finn, K. Barry SharplessAngew Chem Int Ed Engl200111433435Yes
192015591559.077.7977.8Bias in analytic research. D L SackettJ Chronic Dis1979447779Yes
192115591559.036.4336.4The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. H MaedaAdv Enzyme Regul200111384745No
192231141557.058.529.2Mutations affecting segment number and polarity in Drosophila. C Nüsslein-Volhard, E WieschausNature19806776413Yes
192315571557.038.3438.3Use and misuse of the receiver operating characteristic curve in risk prediction. Nancy R CookCirculation200717309939Yes
1924155691556.9370.5437.1Multilineage potential of adult human mesenchymal stem cells. M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R MarshakScience199910102814Yes
192531131556.594.6447.3LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. Roman A Laskowski, Mark B SwindellsJ Chem Inf Model201121919503Yes
192615551555.061.2161.2A structured interview guide for the Hamilton Depression Rating Scale. J B WilliamsArch Gen Psychiatry19883395203Yes
192715551555.031.2231.2The ubiquitin-proteasome proteolytic pathway. A CiechanoverCell19947923371No
192815551555.041.9742.0Stress and depression. Constance HammenAnnu Rev Clin Psychol200517716090No
192915551555.033.4833.5The tumor microenvironment and its role in promoting tumor growth. T L WhitesideOncogene200818836471No
193031081554.081.5540.8The gut microbiota shapes intestinal immune responses during health and disease. June L Round, Sarkis K MazmanianNat Rev Immunol200919343057No
1931108781554.0302.3743.2BLAST+: architecture and applications. Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L MaddenBMC Bioinformatics200920003500Yes
193215531553.035.1335.1Pathogenesis of group A streptococcal infections. M W CunninghamClin Microbiol Rev200010885988No
193331061553.088.2644.1Accessories to the crime: functions of cells recruited to the tumor microenvironment. Douglas Hanahan, Lisa M CoussensCancer Cell201222439926No
193446581552.7103.4734.5Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. M A Frohman, M K Dush, G R MartinProc Natl Acad Sci U S A19882461560Yes
193546581552.7122.7140.9Fast model-based estimation of ancestry in unrelated individuals. David H Alexander, John Novembre, Kenneth LangeGenome Res200919648217Yes
193631051552.5106.5953.3Diabetes and cardiovascular disease. The Framingham study. W B Kannel, D L McGeeJAMA1979430798Yes
193731051552.5116.2458.1Elements of cancer immunity and the cancer-immune set point. Daniel S Chen, Ira MellmanNature201728102259No
193815521552.036.236.2Upconversion and anti-Stokes processes with f and d ions in solids. François AuzelChem Rev200414719973Yes
193931041552.061.9931.0Toll-like receptor control of the adaptive immune responses. Akiko Iwasaki, Ruslan MedzhitovNat Immunol200415454922No
194015521552.042.7242.7Bioactive microbial metabolites. János BérdyJ Antibiot (Tokyo)200515813176No
194146531551.0155.9352.0Phylogenetic identification and in situ detection of individual microbial cells without cultivation. R I Amann, W Ludwig, K H SchleiferMicrobiol Rev19957535888No
194215511551.037.0737.1Myeloperoxidase: friend and foe. Seymour J KlebanoffJ Leukoc Biol200515689384No
194346521550.7128.4142.8Cell death: the significance of apoptosis. A H Wyllie, J F Kerr, A R CurrieInt Rev Cytol19807014501No
194415501550.048.2148.2Evidence for a central component of post-injury pain hypersensitivity. C J WoolfNature19836656869Yes
194530981549.040.0220.0Computed circular dichroism spectra for the evaluation of protein conformation. N Greenfield, G D FasmanBiochemistry19695346390Yes
194615491549.032.332.3Drug discovery: a historical perspective. J DrewsScience200010720314No
194746471549.0702.75234.2MEGA11: Molecular Evolutionary Genetics Analysis Version 11. Koichiro Tamura, Glen Stecher, Sudhir KumarMol Biol Evol202133892491Yes
194846431547.788.5129.5A highly sensitive adenylate cyclase assay. Y Salomon, C Londos, M RodbellAnal Biochem19744827395Yes
194915471547.043.7543.8Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. A E PeggCancer Res19883123052No
195015461546.042.1142.1Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. A FabiatoAm J Physiol19836346892No
195130911545.571.2735.6A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. L Buck, R AxelCell19911840504Yes
195230901545.0182.3991.2Rating systems in the evaluation of knee ligament injuries. Y Tegner, J LysholmClin Orthop Relat Res19854028566Yes
195315451545.048.6748.7The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. G R BuettnerArch Biochem Biophys19938434935No
195430901545.062.9931.5Development by self-digestion: molecular mechanisms and biological functions of autophagy. Beth Levine, Daniel J KlionskyDev Cell200415068787No
195530901545.079.8939.9Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. Gerard Talavera, Jose CastresanaSyst Biol200717654362Yes
195615441544.043.4843.5Surface plasmon resonance sensors for detection of chemical and biological species. Jirí HomolaChem Rev200818229953No
195730861543.079.3639.7Empirical threshold values for quantitative trait mapping. G A Churchill, R W DoergeGenetics19947851788Yes
195830861543.056.7128.4Cellular motility driven by assembly and disassembly of actin filaments. Thomas D Pollard, Gary G BorisyCell200312600310No
195977101542.0152.3530.5Prospective identification of tumorigenic breast cancer cells. Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F ClarkeProc Natl Acad Sci U S A200312629218Yes
196015421542.028.5928.6Vienna RNA secondary structure server. Ivo L HofackerNucleic Acids Res200312824340Yes
196115421542.051.1551.1Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. K Anders EricssonAcad Med200415383395No
196215411541.030.8630.9RNA silencing in plants. David BaulcombeNature200415372043No
196330821541.068.6334.3The DNA damage response: making it safe to play with knives. Alberto Ciccia, Stephen J ElledgeMol Cell201020965415No
196430811540.563.5331.8Coordination of circadian timing in mammals. Steven M Reppert, David R WeaverNature200212198538No
196530811540.562.031.0The Bcl2 family: regulators of the cellular life-or-death switch. Suzanne Cory, Jerry M AdamsNat Rev Cancer200212209154No
1966184821540.2757.5963.1Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Sue Richards, Nazneen Aziz, Sherri Bale, David Bick, Soma Das, Julie Gastier-Foster, Wayne W Grody, Madhuri Hegde, Elaine Lyon, Elaine Spector, Karl Voelkerding, Heidi L RehmGenet Med201525741868No
196715401540.051.3551.4A Social Neuroscience Perspective on Adolescent Risk-Taking. Laurence SteinbergDev Rev200818509515Yes
196830791539.5183.5891.8A scaled version of the General Health Questionnaire. D P Goldberg, V F HillierPsychol Med1979424481Yes
196930771538.576.6238.3Obesity. David W Haslam, W Philip T JamesLancet200516198769No
197015381538.055.3555.4Biological applications of ionophores. B C PressmanAnnu Rev Biochem1976786156No
197115381538.030.2830.3E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. J R NevinsScience19921411535Yes
197215381538.029.9329.9Macromolecular crowding: obvious but underappreciated. R J EllisTrends Biochem Sci200111590012No
197361521538.0120.0130.0A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. B M Bolstad, R A Irizarry, M Astrand, T P SpeedBioinformatics200312538238Yes
197415381538.00.00.0Nutrition needs of mammalian cells in tissue culture. H EagleScience195513255879Yes
197515381538.041.8941.9n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Philip C CalderAm J Clin Nutr200616841861No
197615381538.045.4445.4Signal transduction by reactive oxygen species. Toren FinkelJ Cell Biol201121746850No
197746131537.7117.5439.2Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. B Fischl, M I Sereno, A M DaleNeuroimage19999931269Yes
197830751537.571.4735.7New Giemsa method for the differential staining of sister chromatids. P Perry, S WolffNature19744138930Yes
197930741537.00.00.0A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. G Schmidt, S J ThannhauserJ Biol Chem194521005717Yes
198015361536.059.7259.7MorphoJ: an integrated software package for geometric morphometrics. Christian Peter KlingenbergMol Ecol Resour201121429143Yes
198115361536.043.8243.8Mitochondria and cancer. Douglas C WallaceNat Rev Cancer201223001348No
198230721536.0128.1164.1Sex differences in immune responses. Sabra L Klein, Katie L FlanaganNat Rev Immunol201627546235No
198330711535.568.0934.0ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. Matthew D Wilkerson, D Neil HayesBioinformatics201020427518Yes
198446061535.399.733.2Osteoclast differentiation and activation. William J Boyle, W Scott Simonet, David L LaceyNature200312748652No
198530701535.0103.8751.9Van der Waals heterostructures. A K Geim, I V GrigorievaNature201323887427Yes
198615341534.043.4743.5Glycobiology: Toward Understanding the Function of Sugars. Raymond A. DwekChem Rev199611848770Yes
198730681534.021.5310.8Junctional complexes in various epithelia. M G Farquhar, G E PaladeJ Cell Biol196313944428Yes
198815341534.058.8558.9Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement. Virginia A MoyerAnn Intern Med201424378917No
198915331533.035.8135.8Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Bei-Fan ZhouBiomed Environ Sci200212046553Yes
199030651532.567.5833.8Cell migration: a physically integrated molecular process. D A Lauffenburger, A F HorwitzCell19968608589No
199115321532.048.7648.8Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. C A BarnesJ Comp Physiol Psychol1979221551Yes
199215311531.056.2756.3Statistical analysis of enzyme kinetic data. W W ClelandMethods Enzymol1979502857Yes
199315311531.042.5742.6Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Y Ben-AriNeuroscience19852859548No
199415311531.045.8245.8Recent advances in the biochemistry of polyamines in eukaryotes. A E PeggBiochem J19863087344No
199530611530.567.7233.9NF-kappaB: a key role in inflammatory diseases. P P Tak, G S FiresteinJ Clin Invest200111134171No
1996137731530.3424.1247.1The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C DunbarJ Clin Psychiatry19989881538No
199745881529.3129.4443.1The fusiform face area: a module in human extrastriate cortex specialized for face perception. N Kanwisher, J McDermott, M M ChunJ Neurosci19979151747Yes
199891751529.2282.9447.2TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L SalzbergGenome Biol201323618408Yes
199915291529.066.5966.6Derivation and validation of a short-form oral health impact profile. G D SladeCommunity Dent Oral Epidemiol19979332805Yes
200015281528.041.2941.3Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. L A LiottaCancer Res19862998604No
200115281528.022.2322.2An enzymic method for the trace iodination of immunoglobulins and other proteins. J J MarchalonisBiochem J19694185494Yes
200215281528.031.3731.4Antigen-Antibody Crossed Electrophoresis. C B LaurellAnal Biochem196514302464Yes
200330551527.579.2339.6Lipid rafts as a membrane-organizing principle. Daniel Lingwood, Kai SimonsScience201020044567No
200430551527.593.8646.9Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Riccardo Lencioni, Josep M LlovetSemin Liver Dis201020175033No
200515271527.033.7233.7Molecular themes in oncogenesis. J M BishopCell19911988146No
200615261526.037.9538.0Type I diabetes mellitus. A chronic autoimmune disease. G S EisenbarthN Engl J Med19863517648No
200715261526.033.7433.7Ordered porous materials for emerging applications. Mark E DavisNature200212075343No
200830511525.571.0735.5Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. F Q Schafer, G R BuettnerFree Radic Biol Med200111368918No
200915251525.038.8538.9Early signals in the mitogenic response. E RozengurtScience19863018928No
201015251525.034.634.6Dopamine (3-hydroxytyramine) and brain function. O HornykiewiczPharmacol Rev19665328389No
201130481524.087.5143.8What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. J Zhang, K F YuJAMA19989832001Yes
201245721524.0229.9576.6Radiomics: Images Are More than Pictures, They Are Data. Robert J Gillies, Paul E Kinahan, Hedvig HricakRadiology201626579733Yes
201330471523.5119.0859.5Assessment of eating disorders: interview or self-report questionnaire? C G Fairburn, S J BeglinInt J Eat Disord19947866415Yes
201430471523.580.0740.0Materials for electrochemical capacitors. Patrice Simon, Yury GogotsiNat Mater200818956000Yes
201515231523.050.5450.5Some observations upon a new inhibitor of monoamine oxidase in brain tissue. J P JohnstonBiochem Pharmacol19685659776Yes
201615231523.046.1246.1Domino Reactions in Organic Synthesis. Lutz F. TietzeChem Rev199611848746Yes
201715231523.034.5934.6Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). K M FoxLancet200313678872Yes
201815221522.045.5245.5Calcium release from the sarcoplasmic reticulum. M EndoPhysiol Rev197713441Yes
201945631521.0111.0337.0Membrane lipids: where they are and how they behave. Gerrit van Meer, Dennis R Voelker, Gerald W FeigensonNat Rev Mol Cell Biol200818216768No
202015201520.018.6518.6A soluble protein characteristic of the nervous system. B W MooreBiochem Biophys Res Commun19654953930Yes
202145601520.0117.739.2How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. R M Sapolsky, L M Romero, A U MunckEndocr Rev200010696570No
202215201520.042.1842.2Emotion regulation: affective, cognitive, and social consequences. James J GrossPsychophysiology200212212647No
202315201520.032.632.6Critical period plasticity in local cortical circuits. Takao K HenschNat Rev Neurosci200516261181No
202491191519.8213.7435.6Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O LötvallNat Cell Biol200717486113Yes
202545591519.796.4232.1The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. S K Hanks, A M Quinn, T HunterScience19883291115No
202615191519.090.9891.0Stimulated acoustic emissions from within the human auditory system. D T KempJ Acoust Soc Am1978744838Yes
202730381519.0102.2451.1Thermodynamics of protein association reactions: forces contributing to stability. P D Ross, S SubramanianBiochemistry19817248271Yes
202815191519.049.2449.2The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. Poul Erik PetersenCommunity Dent Oral Epidemiol200315015736Yes
202915191519.031.7931.8Cancer epigenomics: DNA methylomes and histone-modification maps. Manel EstellerNat Rev Genet200717339880No
2030167091519.0437.239.7The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristoGenome Res201020644199Yes
203130351517.5148.4774.2A simple practice guide for dose conversion between animals and human. Anroop B Nair, Shery JacobJ Basic Clin Pharm201627057123No
203215171517.055.7555.8Atherogenesis: a postprandial phenomenon. D B ZilversmitCirculation1979222498Yes
203315171517.028.0328.0Aggresomes, inclusion bodies and protein aggregation. R R KopitoTrends Cell Biol200011121744No
203430331516.565.8132.9Cellular senescence: when bad things happen to good cells. Judith Campisi, Fabrizio d'Adda di FagagnaNat Rev Mol Cell Biol200717667954No
203515151515.037.9538.0Trophic factors and neuronal survival. Y A BardeNeuron19892697237No
203615151515.037.3837.4Reconciling the chemistry and biology of reactive oxygen species. Christine C WinterbournNat Chem Biol200818421291No
203715141514.040.1940.2Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. H S PenefskyJ Biol Chem197716006Yes
203815131513.050.2350.2Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. H J GundersenJ Microsc19863761363Yes
203915121512.066.5566.5Human agency in social cognitive theory. A BanduraAm Psychol19892782727Yes
204015111511.050.050.0The measurement of psychological androgyny. S L BemJ Consult Clin Psychol19744823550Yes
204115111511.046.9947.0The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. J L CummingsNeurology19979153155No
204215111511.038.0838.1Interoception: the sense of the physiological condition of the body. A D CraigCurr Opin Neurobiol200312965300No
204330221511.082.6241.3Genome regulation by long noncoding RNAs. John L Rinn, Howard Y ChangAnnu Rev Biochem201222663078No
204445311510.3156.9852.3CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Teresa C Horan, Mary Andrus, Margaret A DudeckAm J Infect Control200818538699No
204515101510.032.9432.9Far-field optical nanoscopy. Stefan W HellScience200717525330No
204615081508.033.0933.1Hyaluronan: from extracellular glue to pericellular cue. Bryan P TooleNat Rev Cancer200415229478No
204715071507.048.1248.1Health consequences of obesity in youth: childhood predictors of adult disease. W H DietzPediatrics199812224658No
204815071507.033.6333.6The molecular logic of endocannabinoid signalling. Daniele PiomelliNat Rev Neurosci200314595399No
204945201506.7120.5140.2I-TASSER: a unified platform for automated protein structure and function prediction. Ambrish Roy, Alper Kucukural, Yang ZhangNat Protoc201020360767Yes
205015061506.048.3248.3Inflammation in atherosclerosis. Peter LibbyArterioscler Thromb Vasc Biol201222895665No
205130081504.071.9336.0Decision curve analysis: a novel method for evaluating prediction models. Andrew J Vickers, Elena B ElkinMed Decis Making200617099194Yes
205230071503.558.9429.5Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. P J Mitchell, R TjianScience19892667136No
205315031503.048.3248.3SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. B P O'ConnorBehav Res Methods Instrum Comput200011029811Yes
205430051502.589.9745.0Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. P J Basser, C PierpaoliJ Magn Reson B19968661285Yes
205530051502.588.8644.4Porosity of 3D biomaterial scaffolds and osteogenesis. Vassilis Karageorgiou, David KaplanBiomaterials200515860204No
205645071502.3162.1354.0Hydroperoxide metabolism in mammalian organs. B Chance, H Sies, A BoverisPhysiol Rev197937532Yes
2057195221501.7505.8538.9Clustal W and Clustal X version 2.0. M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G HigginsBioinformatics200717846036Yes
205815011501.040.7340.7Rheumatoid arthritis. Pathophysiology and implications for therapy. E D HarrisN Engl J Med19902271017No
205915011501.042.3242.3The Hospital Anxiety And Depression Scale. R Philip SnaithHealth Qual Life Outcomes200312914662Yes
206045001500.050.8416.9Improved method for the determination of blood glutathione. E Beutler, O Duron, B M KellyJ Lab Clin Med196313967893Yes
206114991499.025.3925.4Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. K FuxeActa Physiol Scand Suppl196514319769Yes
206229971498.566.3333.2How matrix metalloproteinases regulate cell behavior. M D Sternlicht, Z WerbAnnu Rev Cell Dev Biol200111687497No
206314981498.035.5735.6Neuronal synchrony: a versatile code for the definition of relations? W SingerNeuron199910677026No
206414981498.032.7932.8The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. S E KahnDiabetologia200312637977No
206514981498.039.1439.1The world health report 2002 - reducing risks, promoting healthy life. J J GuilbertEduc Health (Abingdon)200314741909Yes
206629961498.076.2638.1Abdominal obesity and metabolic syndrome. Jean-Pierre Després, Isabelle LemieuxNature200617167477No
206729961498.073.5736.8Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. Felix Krueger, Simon R AndrewsBioinformatics201121493656Yes
206844941498.0162.9754.3Complex heatmaps reveal patterns and correlations in multidimensional genomic data. Zuguang Gu, Roland Eils, Matthias SchlesnerBioinformatics201627207943Yes
206914971497.051.8651.9Lyme disease. A C SteereN Engl J Med19892668764No
207014971497.042.4142.4Isolated removal of hypothalamic or other brain nuclei of the rat. M PalkovitsBrain Res19734747772Yes
207129941497.00.00.0Lactic dehydrogenase activity in blood. F Wroblewski, J S LadueProc Soc Exp Biol Med195513273400Yes
207214971497.063.3963.4Periodontitis: from microbial immune subversion to systemic inflammation. George HajishengallisNat Rev Immunol201525534621No
207329931496.50.00.0Mutations of Bacteria from Virus Sensitivity to Virus Resistance. S E Luria, M DelbrückGenetics194317247100Yes
207429931496.561.7230.9Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Joshua E Elias, Steven P GygiNat Methods200717327847Yes
207514961496.00.00.0The colorimetric determination of phosphorus. E J KingBiochem J193216744823Yes
207629921496.087.4743.7The cortical organization of speech processing. Gregory Hickok, David PoeppelNat Rev Neurosci200717431404No
207714951495.047.7347.7Stability of proteins: small globular proteins. P L PrivalovAdv Protein Chem197944431No
207814951495.050.9150.9Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. S KatzJ Am Geriatr Soc19836418786No
207914951495.057.6857.7AliView: a fast and lightweight alignment viewer and editor for large datasets. Anders LarssonBioinformatics201425095880Yes
208029891494.587.0543.5Mediation in experimental and nonexperimental studies: new procedures and recommendations. Patrick E Shrout, Niall BolgerPsychol Methods200212530702Yes
2081104611494.4222.9531.8Embryonic stem cell lines derived from human blastocysts. J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M JonesScience19989804556Yes
208214941494.026.3226.3R factor transfer in Rhizobium leguminosarum. J E BeringerJ Gen Microbiol19744612098Yes
208314941494.033.5733.6Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. M B LuskinNeuron19938338665Yes
208429871493.5112.2656.1Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. Susan Whitfield-Gabrieli, Alfonso Nieto-CastanonBrain Connect201222642651Yes
208514931493.033.1533.1Tumor suppressor genes. R A WeinbergScience19911659741No
208614931493.046.5446.5Polycystic ovary syndrome. S FranksN Engl J Med19957651477No
208714931493.071.8571.8Chronic illness as biographical disruption. M BurySociol Health Illn198210260456Yes
208814931493.037.0137.0An economic method for the fluorescent labeling of PCR fragments. M SchuelkeNat Biotechnol200010657137Yes
208929851492.559.9230.0Chemokines: a new classification system and their role in immunity. A Zlotnik, O YoshieImmunity200010714678No
209029851492.564.1632.1Escaping free-energy minima. Alessandro Laio, Michele ParrinelloProc Natl Acad Sci U S A200212271136Yes
209129821491.099.4149.7How useful is SBF in predicting in vivo bone bioactivity? Tadashi Kokubo, Hiroaki TakadamaBiomaterials200616448693No
209214911491.031.3831.4Topoisomerase I inhibitors: camptothecins and beyond. Yves PommierNat Rev Cancer200616990856No
209314911491.031.8331.8Autophagy: from phenomenology to molecular understanding in less than a decade. Daniel J KlionskyNat Rev Mol Cell Biol200717712358No
209429811490.557.0328.5Missing pieces in the NF-kappaB puzzle. Sankar Ghosh, Michael KarinCell200211983155No
209514901490.026.0826.1Histone acetylation and transcriptional regulatory mechanisms. K StruhlGenes Dev19989499396No
209614901490.036.4336.4Fast and robust fixed-point algorithms for independent component analysis. A HyvärinenIEEE Trans Neural Netw199918252563Yes
209714881488.043.2943.3The fetal and infant origins of adult disease. D J BarkerBMJ19902252919No
209814881488.043.143.1Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. M D MainesFASEB J19883290025No
209914871487.034.0734.1Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J C UnkelessJ Exp Med197990108Yes
210014861486.039.1139.1The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. A S FauciScience19883277274No
210114861486.027.4327.4Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. S AvrameasImmunochemistry19694975324Yes
210214841484.019.7719.8Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. J W OlneyScience19695778021Yes
210359341483.5129.532.4Probability-based protein identification by searching sequence databases using mass spectrometry data. D N Perkins, D J Pappin, D M Creasy, J S CottrellElectrophoresis199910612281Yes
210414831483.033.1933.2Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. C TaswellJ Immunol19817009746Yes
210588931482.2261.8543.6The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gøtzsche, Jan P VandenbrouckeLancet200718064739Yes
210614821482.018.4618.5The mechanism of muscular contraction. H E HuxleyScience19694181952No
210714821482.036.8936.9Wound healing and its impairment in the diabetic foot. Vincent FalangaLancet200516291068No
210844451481.779.2326.4Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. C A Winter, E A Risley, G W NussProc Soc Exp Biol Med196214001233Yes
210944441481.393.5531.2TOR signaling in growth and metabolism. Stephan Wullschleger, Robbie Loewith, Michael N HallCell200616469695No
211044401480.045.7215.2The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. J T Dodge, C Mitchell, D J HanahanArch Biochem Biophys196314028302Yes
211114791479.045.5645.6Equipoise and the ethics of clinical research. B FreedmanN Engl J Med19873600702Yes
211214791479.030.5630.6Ionic blockage of sodium channels in nerve. A M WoodhullJ Gen Physiol19734541078Yes
211314791479.054.8254.8Cardiac valve surgery--the "French correction". A CarpentierJ Thorac Cardiovasc Surg19836887954Yes
211459141478.5247.3461.8A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. M A Markwell, S M Haas, L L Bieber, N E TolbertAnal Biochem197898070Yes
211588691478.2259.643.3Cancer statistics, 2009. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J ThunCA Cancer J Clin200919474385Yes
211614781478.043.1843.2Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. E N BergmanPhysiol Rev19902181501No
211714781478.058.5558.5An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. J Kabat-ZinnGen Hosp Psychiatry19827042457Yes
211814781478.039.4439.4Redox signaling: nitrosylation and related target interactions of nitric oxide. J S StamlerCell19947923362No
211914781478.07.97.9Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. R W SperryProc Natl Acad Sci U S A196314077501Yes
212044331477.7111.1137.0The metabolic syndrome. Robert H Eckel, Scott M Grundy, Paul Z ZimmetLancet200515836891No
212114771477.037.1537.1Defective repair replication of DNA in xeroderma pigmentosum. J E CleaverNature19685655953Yes
212214771477.040.1540.1Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. J A BeavoPhysiol Rev19957480160No
212329541477.087.0143.5From best evidence to best practice: effective implementation of change in patients' care. Richard Grol, Jeremy GrimshawLancet200314568747No
212414771477.00.00.0A new readability yardstick. R FleschJ Appl Psychol194818867058Yes
212514771477.059.3359.3The global burden of IBD: from 2015 to 2025. Gilaad G KaplanNat Rev Gastroenterol Hepatol201526323879No
2126132861476.2625.3269.5Cancer statistics in China, 2015. Wanqing Chen, Rongshou Zheng, Peter D Baade, Siwei Zhang, Hongmei Zeng, Freddie Bray, Ahmedin Jemal, Xue Qin Yu, Jie HeCA Cancer J Clin201626808342Yes
212714751475.046.0746.1Superoxide dismutases. I FridovichAnnu Rev Biochem19751094908No
212814751475.033.7733.8The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. M TakeichiDevelopment19883048970No
212914751475.076.2476.2The determinants of parenting: a process model. J BelskyChild Dev19846705636Yes
213014731473.010.6610.7Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. H E HuxleyJ Mol Biol196314064165Yes
213114731473.059.6159.6Working memory: theories, models, and controversies. Alan BaddeleyAnnu Rev Psychol201221961947No
213229451472.5114.0257.0Cisplatin in cancer therapy: molecular mechanisms of action. Shaloam Dasari, Paul Bernard TchounwouEur J Pharmacol201425058905No
213329441472.081.1940.6A general method for isolation of high molecular weight DNA from eukaryotes. N Blin, D W StaffordNucleic Acids Res1976987581Yes
213429441472.076.5338.3The expanding universe of T-cell subsets: Th1, Th2 and more. T R Mosmann, S SadImmunol Today19968820272No
213514721472.034.0834.1Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. P C NowellCancer Res196014427849Yes
213614721472.040.2440.2Leishmaniasis: current situation and new perspectives. P DesjeuxComp Immunol Microbiol Infect Dis200415225981No
213729441472.074.3537.2Molecular replacement with MOLREP. Alexei Vagin, Alexei TeplyakovActa Crystallogr D Biol Crystallogr201020057045Yes
213814701470.036.3736.4Microbial ecology of the gastrointestinal tract. D C SavageAnnu Rev Microbiol1977334036No
213914701470.030.230.2The Relation Of Recombination To Mutational Advance. H J MullerMutat Res196414195748Yes
2140132251469.4408.2645.4The 1982 revised criteria for the classification of systemic lupus erythematosus. E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J WinchesterArthritis Rheum19827138600Yes
214129381469.0199.4799.7ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R. Emmanuel Paradis, Klaus SchliepBioinformatics201930016406Yes
214244061468.7133.6344.5Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. S van der Linden, H A Valkenburg, A CatsArthritis Rheum19846231933Yes
214329361468.091.7445.9Functional architecture of basal ganglia circuits: neural substrates of parallel processing. G E Alexander, M D CrutcherTrends Neurosci19901695401No
214429361468.0107.954.0A new initiative on precision medicine. Francis S Collins, Harold VarmusN Engl J Med201525635347Yes
214543981466.095.631.9Telomeres shorten during ageing of human fibroblasts. C B Harley, A B Futcher, C W GreiderNature19902342578Yes
214614661466.039.4139.4A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. J EngelEpilepsia200111422340Yes
214714661466.00.00.0Modality and topographic properties of single neurons of cat's somatic sensory cortex. V B MountcastleJ Neurophysiol195713439410Yes
214814661466.00.00.0The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. O V BatsonAnn Surg194017857618Yes
214943981466.0219.3773.1Shedding light on the cell biology of extracellular vesicles. Guillaume van Niel, Gisela D'Angelo, Graça RaposoNat Rev Mol Cell Biol201829339798No
215014651465.033.5133.5Simple methods for "staining with lead" at high pH in electron microscopy. M J KarnovskyJ Biophys Biochem Cytol196114454024Yes
215129291464.541.4420.7The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. E G Gray, V P WhittakerJ Anat196213901297Yes
215214641464.042.8142.8Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. M Robin DiMatteoMed Care200415076819Yes
215314631463.033.8333.8PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. B M SpiegelmanDiabetes19989568680No
215414631463.050.8650.9Phase retrieval algorithms: a comparison. J R FienupAppl Opt198220396114Yes
215529251462.588.7444.4CTFFIND4: Fast and accurate defocus estimation from electron micrographs. Alexis Rohou, Nikolaus GrigorieffJ Struct Biol201526278980Yes
215643871462.3126.5742.2Validation of the Insomnia Severity Index as an outcome measure for insomnia research. C H. Bastien, A Vallières, C M. MorinSleep Med200111438246Yes
215714621462.019.5419.5Codon--anticodon pairing: the wobble hypothesis. F H CrickJ Mol Biol19665969078Yes
215814621462.034.2934.3Oxidative stress in Parkinson's disease. Peter JennerAnn Neurol200312666096No
215914621462.040.9541.0Treatment of infections associated with surgical implants. Rabih O DarouicheN Engl J Med200415070792No
216029241462.077.7138.9Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. B R Celli, W MacNeeEur Respir J200415219010No
216114621462.031.8131.8Mitochondria: dynamic organelles in disease, aging, and development. David C ChanCell200616814712No
216214611461.038.1838.2Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Michael F HolickAm J Clin Nutr200415585788No
216343811460.385.6628.6The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Fabio Martinon, Kimberly Burns, Jürg TschoppMol Cell200212191486Yes
216414601460.00.00.0Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. I E BushBiochem J195214915960Yes
216514601460.00.00.0The free amino groups of insulin. F SangerBiochem J194516747948Yes
216614601460.031.831.8DNA damage, aging, and cancer. Jan H J HoeijmakersN Engl J Med200919812404No
216714601460.041.8341.8Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Charles A DinarelloBlood201121304099No
216829191459.567.6633.8The MAPK signaling cascade. R Seger, E G KrebsFASEB J19957601337No
216914591459.043.8543.9The functional gastrointestinal disorders and the Rome III process. Douglas A DrossmanGastroenterology200616678553No
217014591459.032.9733.0Cell signaling. H2O2, a necessary evil for cell signaling. Sue Goo RheeScience200616809515Yes
217114581458.056.9256.9Reliability and factor analysis of the Epworth Sleepiness Scale. M W JohnsSleep19921519015Yes
217229161458.098.3849.2Peptidoglycan types of bacterial cell walls and their taxonomic implications. K H Schleifer, O KandlerBacteriol Rev19724568761No
217314581458.094.1594.2The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. F DenisSpine (Phila Pa 1976)19836670016Yes
217414581458.036.4436.4Stress and hippocampal plasticity. B S McEwenAnnu Rev Neurosci199910202533No
217529151457.573.6236.8Morris water maze: procedures for assessing spatial and related forms of learning and memory. Charles V Vorhees, Michael T WilliamsNat Protoc200617406317Yes
217614571457.034.3634.4Binary Agrobacterium vectors for plant transformation. M BevanNucleic Acids Res19846095209Yes
217714571457.033.3733.4Nonaqueous liquid electrolytes for lithium-based rechargeable batteries. Kang XuChem Rev200415669157Yes
217829131456.557.8528.9Intrinsically unstructured proteins and their functions. H Jane Dyson, Peter E WrightNat Rev Mol Cell Biol200515738986No
217914561456.035.6135.6The amygdala modulates the consolidation of memories of emotionally arousing experiences. James L McGaughAnnu Rev Neurosci200415217324No
218014561456.064.8564.8Mechanisms linking social ties and support to physical and mental health. Peggy A ThoitsJ Health Soc Behav201121673143No
218129111455.5119.5259.83D bioprinting of tissues and organs. Sean V Murphy, Anthony AtalaNat Biotechnol201425093879Yes
218214551455.036.8936.9Hemispheric asymmetry reduction in older adults: the HAROLD model. Roberto CabezaPsychol Aging200211931290No
218314551455.00.00.0A modified ninhydrin colorimetric analysis for amino acids. H RosenArch Biochem Biophys195713412116Yes
218414541454.050.9551.0The prevalence of 'alexithymic' characteristics in psychosomatic patients. P E SifneosPsychother Psychosom19734770536Yes
218529061453.0103.5551.8Assay of proteins in the presence of interfering materials. A Bensadoun, D WeinsteinAnal Biochem19761259145Yes
218614531453.046.1846.2A clinical method for assessing the ventilatory response to carbon dioxide. D J ReadAustralas Ann Med19676032026Yes
218714531453.029.6729.7Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. S S FergusonPharmacol Rev200111171937No
2188116191452.4288.9136.1Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M JoliotNeuroimage200211771995Yes
218914521452.028.8928.9The organization of proteins in the human red blood cell membrane. A review. T L SteckJ Cell Biol19744600883No
219014521452.031.5231.5Protein misfolding, evolution and disease. C M DobsonTrends Biochem Sci199910470028No
219129041452.00.00.0Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. D H Clarke, J CasalsAm J Trop Med Hyg195813571577Yes
219229031451.574.5937.3Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. I Issemann, S GreenNature19902129546Yes
219329031451.573.4236.7A globally coherent fingerprint of climate change impacts across natural systems. Camille Parmesan, Gary YoheNature200312511946Yes
219443541451.3101.2833.8Long non-coding RNAs: insights into functions. Tim R Mercer, Marcel E Dinger, John S MattickNat Rev Genet200919188922No
219514511451.034.734.7Origin, biogenesis, and activity of plant microRNAs. Olivier VoinnetCell200919239888No
219629011450.593.1346.6Synchronization of Plasmodium falciparum erythrocytic stages in culture. C Lambros, J P VanderbergJ Parasitol1979383936Yes
219758011450.2211.7652.9FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs SchoffelenComput Intell Neurosci201121253357Yes
219814501450.057.6257.6Social phobia. M R LiebowitzMod Probl Pharmacopsychiatry19872885745Yes
219928991449.579.3739.7A rapid boiling method for the preparation of bacterial plasmids. D S Holmes, M QuigleyAnal Biochem19816269464Yes
220014491449.035.5235.5General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. R A HoughtenProc Natl Acad Sci U S A19852410914Yes
220114491449.040.1540.1Graphene transistors. Frank SchwierzNat Nanotechnol201020512128Yes
220228961448.075.3537.73' non-coding region sequences in eukaryotic messenger RNA. N J Proudfoot, G G BrownleeNature1976822353Yes
220314481448.048.5848.6Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. G A McPhersonJ Pharmacol Methods19853840547Yes
220443431447.792.5930.9NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. S Ghosh, M J May, E B KoppAnnu Rev Immunol19989597130No
220528951447.594.7547.4The efficiency of systematic sampling in stereology and its prediction. H J Gundersen, E B JensenJ Microsc19873430576Yes
220657901447.5162.5140.6The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. L A Sternberger, P H Hardy, J J Cuculis, H G MeyerJ Histochem Cytochem19704192899Yes
220757891447.2146.936.7Microbial ecology: human gut microbes associated with obesity. Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I GordonNature200617183309Yes
220814471447.033.5733.6Developmental cell death: morphological diversity and multiple mechanisms. P G ClarkeAnat Embryol (Berl)19902186664No
220928941447.066.0633.0Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. C Auffray, F RougeonEur J Biochem19806772444Yes
221014461446.030.2930.3Neurotrophins as synaptic modulators. M M PooNat Rev Neurosci200111253356No
221128921446.062.0431.0A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. A H Anton, D F SayreJ Pharmacol Exp Ther196214013351Yes
221214451445.035.8635.9The 'effective number of codons' used in a gene. F WrightGene19902110097Yes
221328901445.060.2130.1The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. M S Brown, J L GoldsteinCell19979150132No
221414431443.037.8837.9Cell and environment interactions in tumor microregions: the multicell spheroid model. R M SutherlandScience19882451290Yes
221514431443.036.7136.7The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. T SzkudelskiPhysiol Res200111829314No
221628851442.586.0643.0The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. J D Hayes, D J PulfordCrit Rev Biochem Mol Biol19958770536No
221714421442.00.00.0Potential, Impedance, And Rectification In Membranes. D E GoldmanJ Gen Physiol194319873371Yes
221814421442.040.740.7Breakthrough of the year 2013. Cancer immunotherapy. Jennifer Couzin-FrankelScience201324357284No
221928831441.50.00.0Mutants of Escherichia coli requiring methionine or vitamin B12. B D Davis, E S MingioliJ Bacteriol195015436457Yes
222014411441.042.2942.3Human cardiovascular adjustments to exercise and thermal stress. L B RowellPhysiol Rev19744587247No
222128811440.578.3639.2Angiogenesis. J Folkman, Y ShingJ Biol Chem19921375931No
222214401440.048.1248.1Gene flow and the geographic structure of natural populations. M SlatkinScience19873576198Yes
222314401440.049.849.8Colorimetric determination of phospholipids with ammonium ferrothiocyanate. J C StewartAnal Biochem19806892980Yes
222414391439.00.00.0Starch gel electrophoresis in a discontinous system of buffers. M D PoulikNature195713493570Yes
222514391439.044.9444.9Amino acids: metabolism, functions, and nutrition. Guoyao WuAmino Acids200919301095No
222628771438.557.2528.6Short-term synaptic plasticity. Robert S Zucker, Wade G RegehrAnnu Rev Physiol200211826273No
222728771438.50.00.0Brain stem reticular formation and activation of the EEG. G Moruzzi, H W MagounElectroencephalogr Clin Neurophysiol194918421835Yes
222828751437.567.4233.7Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. H Cai, D G HarrisonCirc Res200011073878No
222928751437.586.6243.3An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. O Johnell, J A KanisOsteoporos Int200616983459Yes
223057491437.2168.042.0Reversible middle cerebral artery occlusion without craniectomy in rats. E Z Longa, P R Weinstein, S Carlson, R CumminsStroke19892643202Yes
223114371437.094.3194.3The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. F C EwaldClin Orthop Relat Res19892805502Yes
223214371437.036.536.5The intraclass correlation coefficient as a measure of reliability. J J BartkoPsychol Rep19665942109Yes
223314371437.042.8242.8The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Artemis P SimopoulosExp Biol Med (Maywood)200818408140No
223428721436.055.3127.7Autophagy as a regulated pathway of cellular degradation. D J Klionsky, S D EmrScience200011099404No
223528721436.00.00.0Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. H J Bloom, W W RichardsonBr J Cancer195713499785Yes
223614361436.062.2762.3Machine Learning in Medicine. Rahul C DeoCirculation201526572668No
223714351435.037.037.0Capacitative calcium entry revisited. J W PutneyCell Calcium19901965707No
223814351435.043.7543.8Biological basis of the behavior of sick animals. B L HartNeurosci Biobehav Rev19883050629No
223914351435.021.4421.4Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. K S McCullyAm J Pathol19695792556Yes
224014351435.053.853.8Diversity in tropical rain forests and coral reefs. J H ConnellScience197817840770Yes
224114341434.049.9349.9Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. Russell LandeEvolution197928568194Yes
224228671433.573.1836.6Alternative activation of macrophages: mechanism and functions. Siamon Gordon, Fernando O MartinezImmunity201020510870No
224314331433.042.5742.6Strong localization of photons in certain disordered dielectric superlattices. S JohnPhys Rev Lett198710034761Yes
224428641432.053.7526.9T-cell antigen receptor genes and T-cell recognition. M M Davis, P J BjorkmanNature19883043226No
224571551431.0154.0930.8Site-directed mutagenesis by overlap extension using the polymerase chain reaction. S N Ho, H D Hunt, R M Horton, J K Pullen, L R PeaseGene19892744487Yes
224614311431.060.460.4The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. E J KhantzianAm J Psychiatry19853904487No
224714311431.033.7733.8Proinflammatory cytokines. C A DinarelloChest200010936147No
224828601430.097.9449.0The framing of decisions and the psychology of choice. A Tversky, D KahnemanScience19817455683Yes
224928591429.5100.4550.2Selective loss of central cholinergic neurons in Alzheimer's disease. P Davies, A J MaloneyLancet197663862Yes
225042881429.386.4828.8Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Michael J Rust, Mark Bates, Xiaowei ZhuangNat Methods200616896339Yes
225142851428.3122.1840.7Dose translation from animal to human studies revisited. Shannon Reagan-Shaw, Minakshi Nihal, Nihal AhmadFASEB J200817942826Yes
225214281428.043.2443.2Mate selection-a selection for a handicap. A ZahaviJ Theor Biol19751195756Yes
225314281428.037.3237.3The epidemiology of venous thromboembolism. Richard H WhiteCirculation200312814979No
225414281428.027.2927.3The significance of responses of the genome to challenge. B McClintockScience198415739260No
225514281428.051.0551.0Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. T Florian JaegerJ Mem Lang200819884961Yes
225628541427.070.1835.1Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. E S Lander, D BotsteinGenetics19892563713Yes
225714271427.041.0541.0The aging process. D HarmanProc Natl Acad Sci U S A19816947277Yes
225842811427.088.0529.3Toll-like receptors. Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo AkiraAnnu Rev Immunol200312524386No
225914271427.040.6740.7Recent developments in isocyanide based multicomponent reactions in applied chemistry. Alexander DömlingChem Rev200616402771No
226057071426.8156.1439.0Image quality assessment: from error visibility to structural similarity. Zhou Wang, Alan Conrad Bovik, Hamid Rahim Sheikh, Eero P SimoncelliIEEE Trans Image Process200415376593Yes
226114261426.00.00.0Notes on continuous stochastic phenomena. P A P MoranBiometrika195015420245Yes
226214261426.00.00.0The generalisation of student's problems when several different population variances are involved. B L WelchBiometrika194720287819Yes
226357031425.8258.5364.6Prevalence of childhood and adult obesity in the United States, 2011-2012. Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M FlegalJAMA201424570244Yes
226414241424.039.9239.9Isolation and cultivation of Lyme disease spirochetes. A G BarbourYale J Biol Med19846393604Yes
226514241424.040.7540.8Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. M LeavittMedGenMed200111549951No
226614241424.033.7833.8The use of nanocrystals in biological detection. Paul AlivisatosNat Biotechnol200414704706Yes
226714241424.044.2944.3Formation of glasses from liquids and biopolymers. C A AngellScience199517770101Yes
226828471423.554.9827.5Cancer genes and the pathways they control. Bert Vogelstein, Kenneth W KinzlerNat Med200415286780No
226914231423.025.6525.6The DNA methyltransferases of mammals. T H BestorHum Mol Genet200011005794No
227014221422.026.6326.6Ubiquitin-dependent protein degradation. M HochstrasserAnnu Rev Genet19968982460No
227114211421.033.3433.3Functions of ceramide in coordinating cellular responses to stress. Y A HannunScience19968943189No
227214211421.040.8540.9Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. J WymanAdv Protein Chem196414268785No
227314211421.039.9339.9BEDTools: The Swiss-Army Tool for Genome Feature Analysis. Aaron R QuinlanCurr Protoc Bioinformatics201425199790Yes
227414201420.051.4851.5Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. M P BlausteinAm J Physiol1977324293No
227514201420.039.2439.2The debate over dopamine's role in reward: the case for incentive salience. Kent C BerridgePsychopharmacology (Berl)200717072591No
227628381419.079.3139.7Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. F D Lublin, S C ReingoldNeurology19968780061Yes
227728371418.581.7340.9CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. Mattias Jakobsson, Noah A RosenbergBioinformatics200717485429Yes
227814181418.024.5524.6The economics of ribosome biosynthesis in yeast. J R WarnerTrends Biochem Sci199910542411No
227914181418.037.6437.6A note on robust variance estimation for cluster-correlated data. R L WilliamsBiometrics200010877330Yes
228028351417.554.9227.5Wnt signalling in stem cells and cancer. Tannishtha Reya, Hans CleversNature200515829953No
228114171417.035.7835.8Diagnosis of osteoporosis and assessment of fracture risk. John A KanisLancet200212057569No
228214171417.044.3744.4The role of autophagy in neurodegenerative disease. Ralph A NixonNat Med201323921753No
228384971416.2278.5146.4Antioxidant activity applying an improved ABTS radical cation decolorization assay. R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-EvansFree Radic Biol Med199910381194Yes
228428321416.089.8844.9Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. Johan W S Vlaeyen, Steven J LintonPain200010781906No
228528311415.582.441.2Physiological time-series analysis using approximate entropy and sample entropy. J S Richman, J R MoormanAm J Physiol Heart Circ Physiol200010843903Yes
228642451415.0139.9646.7Vascular endothelial cells synthesize nitric oxide from L-arginine. R M Palmer, D S Ashton, S MoncadaNature19883131684Yes
228728301415.083.8341.9Intracellular pH. A Roos, W F BoronPhysiol Rev19817012859No
228814141414.033.6633.7Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. S S LehrerBiochemistry19715119250Yes
228942411413.7144.5348.2Factor structure of the Barratt impulsiveness scale. J H Patton, M S Stanford, E S BarrattJ Clin Psychol19958778124Yes
229084781413.0217.0236.2Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur WheelerN Engl J Med200010793162Yes
229128251412.588.5644.3Performing the exact test of Hardy-Weinberg proportion for multiple alleles. S W Guo, E A ThompsonBiometrics19921637966Yes
229242371412.3147.9949.3Structure-antioxidant activity relationships of flavonoids and phenolic acids. C A Rice-Evans, N J Miller, G PagangaFree Radic Biol Med19968743980Yes
229314121412.050.8750.9The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. A RaineSchizophr Bull19911805349Yes
229428241412.052.4126.2Oncogenic kinase signalling. P Blume-Jensen, T HunterNature200111357143No
229514121412.066.2766.3A New Weighting System For Mean Surface Temperature Of The Human Body. N L RamanathanJ Appl Physiol196414173555Yes
229628231411.586.2243.1Unidentified curved bacilli on gastric epithelium in active chronic gastritis. J R Warren, B MarshallLancet19836134060Yes
229714111411.035.4735.5Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. Y ShaiBiochim Biophys Acta199910590302No
229814101410.034.6334.6The cancer stem cell: premises, promises and challenges. Hans CleversNat Med201121386835No
229942281409.3101.0833.7Wnt/beta-catenin signaling: components, mechanisms, and diseases. Bryan T MacDonald, Keiko Tamai, Xi HeDev Cell200919619488No
230014091409.045.9646.0Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. N KriegerAm J Public Health19921566949Yes
230128181409.00.00.0Virus interference. I. The interferon. A Isaacs, J LindenmannProc R Soc Lond B Biol Sci195713465720Yes
230214081408.063.2263.2Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. P de LevaJ Biomech19968872282Yes
230328161408.072.3936.2EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. Stefan Stoll, Arthur SchweigerJ Magn Reson200616188474Yes
230428151407.589.2744.6The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. W R Gibb, A J LeesJ Neurol Neurosurg Psychiatry19882841426No
230528151407.562.331.1The pathophysiology and treatment of sepsis. Richard S Hotchkiss, Irene E KarlN Engl J Med200312519925No
230642211407.093.7431.2OrthoMCL: identification of ortholog groups for eukaryotic genomes. Li Li, Christian J Stoeckert, David S RoosGenome Res200312952885Yes
230728131406.50.00.0The effect of sodium ions on the electrical activity of giant axon of the squid. A L Hodgkin, B KatzJ Physiol194918128147Yes
230814061406.064.6164.6PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors. Anthony L SpekActa Crystallogr C Struct Chem201525567569Yes
230928111405.581.3840.7Empirical predictions of protein conformation. P Y Chou, G D FasmanAnnu Rev Biochem1978354496No
231028111405.569.6934.8Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. M D Pierschbacher, E RuoslahtiNature19846325925Yes
231128091404.576.9738.5Transforming growth factor beta in tissue fibrosis. W A Border, N A NobleN Engl J Med19947935686No
231214041404.032.7832.8Speculations on the functions of the major heat shock and glucose-regulated proteins. H R PelhamCell19862944601Yes
231314041404.025.3225.3Selection of successive tumour lines for metastasis. I J FidlerNat New Biol19734512654Yes
231428061403.0147.6473.8Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. L F Berkman, S L SymeAm J Epidemiol1979425958Yes
231528061403.070.9435.5CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. D G Higgins, P M SharpGene19883243435Yes
231614031403.033.3633.4The basic science of gene therapy. R C MulliganScience19938493530No
231728051402.569.935.0Molecular beacons: probes that fluoresce upon hybridization. S Tyagi, F R KramerNat Biotechnol19969630890Yes
231814021402.026.1526.1NK cell receptors. L L LanierAnnu Rev Immunol19989597134No
231914021402.036.2936.3Genetic consequences of climatic oscillations in the Quaternary. G M HewittPhilos Trans R Soc Lond B Biol Sci200415101575No
232014021402.063.0663.1Oxidative stress: a concept in redox biology and medicine. Helmut SiesRedox Biol201525588755No
232128031401.562.3931.2Raster3D Version 2.0. A program for photorealistic molecular graphics. E A Merritt, M E MurphyActa Crystallogr D Biol Crystallogr199415299354Yes
232228001400.042.0221.0Prediction of protein conformation. P Y Chou, G D FasmanBiochemistry19744358940Yes
232314001400.040.5540.5Depression in late life: review and commentary. Dan G BlazerJ Gerontol A Biol Sci Med Sci200312634292No
232414001400.034.8534.9Mitochondrial fusion and fission in cell life and death. Benedikt WestermannNat Rev Mol Cell Biol201021102612No
232513991399.030.6730.7The ATP synthase--a splendid molecular machine. P D BoyerAnnu Rev Biochem19979242922No
232641951398.3106.4735.5Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Robert D Schreiber, Lloyd J Old, Mark J SmythScience201121436444No
232713981398.031.5631.6The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. R C LewontinGenetics196417248194Yes
232813971397.029.0529.1Origin of concatemeric T7 DNA. J D WatsonNat New Biol19724507727Yes
232927941397.099.5549.8Role of the microbiota in immunity and inflammation. Yasmine Belkaid, Timothy W HandCell201424679531No
233027921396.082.441.2Glycine potentiates the NMDA response in cultured mouse brain neurons. J W Johnson, P AscherNature19872433595Yes
233113961396.031.9431.9Protein kinase C: structure, function, and regulation. A C NewtonJ Biol Chem19957499357No
233213961396.033.9133.9Tobacco smoke carcinogens and lung cancer. S S HechtJ Natl Cancer Inst199910413421No
233313961396.030.2830.3Target-oriented and diversity-oriented organic synthesis in drug discovery. S L SchreiberScience200010720315No
233427921396.068.7934.4Myocardial reperfusion injury. Derek M Yellon, Derek J HausenloyN Engl J Med200717855673No
233527911395.569.2934.6Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. E Engvall, P PerlmannImmunochemistry19715135623Yes
233641861395.3196.5265.5Risk factors for falls among elderly persons living in the community. M E Tinetti, M Speechley, S F GinterN Engl J Med19883205267Yes
233713951395.017.4117.4Hippocampal electrical activity and voluntary movement in the rat. C H VanderwolfElectroencephalogr Clin Neurophysiol19694183562Yes
233827901395.061.4230.7An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. A A Beg, D BaltimoreScience19968864118Yes
233913951395.044.1344.1Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. J J GrossJ Pers Soc Psychol19989457784Yes
234027901395.083.4641.7Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. D Filmer, L H PritchettDemography200111227840Yes
234113951395.029.6129.6Cancer of the ovary. Stephen A CannistraN Engl J Med200415590954No
234213941394.050.1250.1Quantitative methods in the review of epidemiologic literature. S GreenlandEpidemiol Rev19873678409Yes
234327881394.081.8740.9Microdetermination of long-chain fatty acids in plasma and tissues. V P Dole, H MeinertzJ Biol Chem196013817286Yes
234427871393.565.7932.9Inflammation, stress, and diabetes. Kathryn E Wellen, Gökhan S HotamisligilJ Clin Invest200515864338No
234513931393.052.8852.9Presidential address, 1980. Surprise!...Surprise? E DonchinPsychophysiology19817280146Yes
234613931393.029.4829.5A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Dale R NyholtAm J Hum Genet200414997420Yes
234769631392.6257.0851.4Evidence based medicine: what it is and what it isn't. D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S RichardsonBMJ19968555924No
234813921392.033.2333.2Drug-induced prolongation of the QT interval. Dan M RodenN Engl J Med200414999113No
234927831391.567.3633.7Powering the planet: chemical challenges in solar energy utilization. Nathan S Lewis, Daniel G NoceraProc Natl Acad Sci U S A200617043226Yes
235041741391.387.829.3Multidrug resistance in cancer: role of ATP-dependent transporters. Michael M Gottesman, Tito Fojo, Susan E BatesNat Rev Cancer200211902585No
235113911391.026.9426.9Natively unfolded proteins: a point where biology waits for physics. Vladimir N UverskyProtein Sci200211910019No
235213911391.024.4624.5The snail superfamily of zinc-finger transcription factors. M Angela NietoNat Rev Mol Cell Biol200211994736No
235341681389.3111.4237.1TCS: a computer program to estimate gene genealogies. M Clement, D Posada, K A CrandallMol Ecol200011050560Yes
235427781389.074.3437.2Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Robert E W Hancock, Hans-Georg SahlNat Biotechnol200617160061No
235541661388.783.928.0The versatility and universality of calcium signalling. M J Berridge, P Lipp, M D BootmanNat Rev Mol Cell Biol200011413485No
235627761388.0108.3854.2Natural products as sources of new drugs over the 30 years from 1981 to 2010. David J Newman, Gordon M CraggJ Nat Prod201222316239No
235741631387.7135.5145.2Global estimates of the prevalence of diabetes for 2010 and 2030. J E Shaw, R A Sicree, P Z ZimmetDiabetes Res Clin Pract201019896746Yes
235813871387.00.00.0An approximate distribution of estimates of variance components. F E SatterthwaiteBiometrics194620287815Yes
235955471386.8210.252.5Bayesian phylogenetics with BEAUti and the BEAST 1.7. Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew RambautMol Biol Evol201222367748Yes
236013861386.035.4535.5The human orbitofrontal cortex: linking reward to hedonic experience. Morten L KringelbachNat Rev Neurosci200516136173No
236113861386.043.8543.9The amazing osteocyte. Lynda F BonewaldJ Bone Miner Res201121254230No
236213861386.044.2644.3Synopsis of some recent tactical application of bioisosteres in drug design. Nicholas A MeanwellJ Med Chem201121413808Yes
236327711385.594.8747.4A new scale of social desirability independent of psychopathology. D P Crowne, D MarloweJ Consult Psychol196013813058Yes
236427701385.071.5835.8A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. J Messing, J VieiraGene19826295880Yes
236513851385.0129.26129.3A Review of Coronavirus Disease-2019 (COVID-19). Tanu SinghalIndian J Pediatr202032166607No
236641541384.798.8933.0Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Daniel Falush, Matthew Stephens, Jonathan K PritchardGenetics200312930761Yes
236727691384.580.1140.1Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. C J Murray, A D LopezLancet19979164317Yes
236813841384.050.4850.5The structure of beta-lactamases. R P AmblerPhilos Trans R Soc Lond B Biol Sci19806109327Yes
236927681384.0100.7150.4Biology of disease: free radicals and tissue injury. B A Freeman, J D CrapoLab Invest19826290784No
237013841384.032.0232.0Huntington's disease. Francis O WalkerLancet200717240289No
237113831383.030.7130.7Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. M KozakMicrobiol Rev19836343825No
237227661383.061.3830.7Immunoassay of endogenous plasma insulin in man. R S Yalow, S A BersonJ Clin Invest196013846364Yes
237369141382.8200.2740.1Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939839Yes
237427651382.554.8627.4Prediction of complete gene structures in human genomic DNA. C Burge, S KarlinJ Mol Biol19979149143Yes
237513821382.00.00.0Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. W C SchneiderJ Biol Chem194818886166Yes
237627631381.563.1431.6A method of trace iodination of proteins for immunologic studies. P J McConahey, F J DixonInt Arch Allergy Appl Immunol19664160044Yes
237713801380.033.8133.8The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. R G KhalifahJ Biol Chem19714994926Yes
237813791379.051.951.9Translating social ecological theory into guidelines for community health promotion. D StokolsAm J Health Promot199610159709No
237968901378.0260.8152.2Fsl. Mark Jenkinson, Christian F Beckmann, Timothy E J Behrens, Mark W Woolrich, Stephen M SmithNeuroimage201221979382No
238013771377.042.9442.9The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. L W SwansonBrain Res Bull19826816390Yes
238113771377.032.2932.3Regulation of differentiation of vascular smooth muscle cells. G K OwensPhysiol Rev19957624392No
238227531376.594.4347.2Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. D H Figurski, D R HelinskiProc Natl Acad Sci U S A1979377280Yes
238368811376.2308.161.6BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs. Felipe A Simão, Robert M Waterhouse, Panagiotis Ioannidis, Evgenia V Kriventseva, Evgeny M ZdobnovBioinformatics201526059717Yes
238413761376.059.6959.7Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. T SpectorAnal Biochem1978655375Yes
238513761376.039.2339.2Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. P WillnerPsychopharmacology (Berl)19979452163No
238613761376.030.9631.0Molecular basis of long-term plasticity underlying addiction. E J NestlerNat Rev Neurosci200111252991No
238727511375.570.4435.2Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. D Marion, K WüthrichBiochem Biophys Res Commun19836307308Yes
238827501375.080.0940.0Software survey: VOSviewer, a computer program for bibliometric mapping. Nees Jan van Eck, Ludo WaltmanScientometrics201020585380Yes
238927481374.063.3831.7Emerging roles of caspase-3 in apoptosis. A G Porter, R U JänickeCell Death Differ199910200555No
239013741374.037.5237.5The pollution of the marine environment by plastic debris: a review. José G B DerraikMar Pollut Bull200212405208No
239113741374.032.0632.1Recent advances in neuroblastoma. John M MarisN Engl J Med201020558371No
239213731373.025.9525.9Epithelial-mesenchymal transitions in development and pathologies. Jean Paul ThieryCurr Opin Cell Biol200314644200No
239327451372.573.5236.8Antibiotic resistance of bacteria in biofilms. P S Stewart, J W CostertonLancet200111463434No
239427441372.058.0129.0LTP and LTD: an embarrassment of riches. Robert C Malenka, Mark F BearNeuron200415450156No
239527431371.577.3538.7Mortality by cause for eight regions of the world: Global Burden of Disease Study. C J Murray, A D LopezLancet19979142060Yes
239668571371.4166.9733.4Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory CollinsLancet200212493255Yes
239713711371.021.4921.5Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. J R DavidProc Natl Acad Sci U S A19665229858Yes
239813711371.022.3622.4Cancer. Addiction to oncogenes--the Achilles heal of cancer. I Bernard WeinsteinScience200212098689No
239927411370.587.3943.7Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. A Dahlstroem, K FuxeActa Physiol Scand Suppl196414229500Yes
240027411370.588.5244.3Origins and evolution of antibiotic resistance. Julian Davies, Dorothy DaviesMicrobiol Mol Biol Rev201020805405No
240113701370.028.3928.4Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. R I MorimotoGenes Dev19989869631No
240227401370.068.234.1The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Clay B Holroyd, Michael G H ColesPsychol Rev200212374324Yes
240327401370.065.4932.7Regulation mechanisms and signaling pathways of autophagy. Congcong He, Daniel J KlionskyAnnu Rev Genet200919653858No
240413701370.048.2348.2The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. Eleonore FröhlichInt J Nanomedicine201223144561No
240527391369.555.3427.7Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. A J Berk, P A SharpCell1977922889Yes
240641081369.391.5230.5Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. Christian W Tornøe, Caspar Christensen, Morten MeldalJ Org Chem200211975567Yes
240713691369.036.2436.2Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. P LipsEndocr Rev200111493580No
240827371368.589.1644.6A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. R L Juliano, V LingBiochim Biophys Acta1976990323Yes
240913681368.030.2430.2The origin of the genetic code. F H CrickJ Mol Biol19684887876Yes
241027351367.576.5638.3Epidemiology of invasive candidiasis: a persistent public health problem. M A Pfaller, D J DiekemaClin Microbiol Rev200717223626No
241141021367.3119.7339.9Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Garnier, D J Osguthorpe, B RobsonJ Mol Biol1978642007Yes
241213671367.058.0258.01,500 scientists lift the lid on reproducibility. Monya BakerNature201627225100No
241313661366.031.3131.3Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? Rui WangFASEB J200212409322Yes
241413661366.00.00.0The critical incident technique. J C FlanaganPsychol Bull195413177800Yes
241513661366.00.00.0An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. O SmithiesBiochem J195913638269Yes
241613661366.027.9728.0Stability and flexibility of epigenetic gene regulation in mammalian development. Wolf ReikNature200717522676No
241713661366.056.456.4Transcriptional architecture of the mammalian circadian clock. Joseph S TakahashiNat Rev Genet201727990019No
241881931365.5205.3134.2A default mode of brain function. M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L ShulmanProc Natl Acad Sci U S A200111209064Yes
241927311365.566.6433.3The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Daniel J Drucker, Michael A NauckLancet200617098089No
242013651365.046.8846.9Multiple calcium channels and neuronal function. R J MillerScience19872432656No
242113651365.029.7229.7Physiological concentrations of purines and pyrimidines. T W TrautMol Cell Biochem19947877593No
242227271363.566.5633.3Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. M P Lutolf, J A HubbellNat Biotechnol200515637621No
242313631363.036.2436.2Sarcopenia: origins and clinical relevance. I H RosenbergJ Nutr19979164280No
242427261363.00.00.0The respiratory chain and oxidative phosphorylation. B Chance, G R WilliamsAdv Enzymol Relat Subj Biochem195613313307Yes
242554521363.0135.7633.9Universal sample preparation method for proteome analysis. Jacek R Wiśniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias MannNat Methods200919377485Yes
242613631363.052.7352.7What is self-rated health and why does it predict mortality? Towards a unified conceptual model. Marja JylhäSoc Sci Med200919520474Yes
242727261363.074.0737.0miRBase: integrating microRNA annotation and deep-sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201121037258Yes
242895401362.9386.3855.2Development and validation of a geriatric depression screening scale: a preliminary report. J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O LeirerJ Psychiatr Res19827183759Yes
242913621362.029.9429.9Diarylethenes for Memories and Switches. Masahiro IrieChem Rev200011777416Yes
243013621362.024.2224.2Chromatin modification and epigenetic reprogramming in mammalian development. En LiNat Rev Genet200212209141No
243113621362.036.436.4Atopic dermatitis. Thomas BieberN Engl J Med200818385500Yes
243240851361.7116.6138.9A rapid bootstrap algorithm for the RAxML Web servers. Alexandros Stamatakis, Paul Hoover, Jacques RougemontSyst Biol200818853362Yes
243327231361.552.1226.1A protein sequenator. P Edman, G BeggEur J Biochem19676059350Yes
243427231361.596.1148.1A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. C M Tsai, C E FraschAnal Biochem19826176137Yes
243527231361.556.2628.1Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. P J Southern, P BergJ Mol Appl Genet19826286831Yes
243627231361.559.2329.6NMR View: A computer program for the visualization and analysis of NMR data. B A Johnson, R A BlevinsJ Biomol NMR199422911360Yes
243740831361.0148.7449.6Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. C J Caspersen, K E Powell, G M ChristensonPublic Health Rep19853920711Yes
243813611361.046.3746.4Interleukin-1. C A DinarelloRev Infect Dis19846369481No
243940831361.099.4133.1Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. Y Zhang, M Brady, S SmithIEEE Trans Med Imaging200111293691Yes
244027211360.580.2340.1The Measurement Of Selection On Correlated Characters. Russell Lande, Stevan J ArnoldEvolution198328556011Yes
244127201360.079.7639.9A cognitive model of posttraumatic stress disorder. A Ehlers, D M ClarkBehav Res Ther200010761279No
244213601360.040.5540.5Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. Chao-Jun LiAcc Chem Res200919220064Yes
244313591359.032.6632.7Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. G von HeijneJ Mol Biol19921593632Yes
244413591359.00.00.0Effects of varying the vehicle for OsO4 in tissue fixation. J B CaulfieldJ Biophys Biochem Cytol195713475399Yes
244513581358.043.5343.5History of the Rochester Epidemiology Project. L J MeltonMayo Clin Proc19968594285No
244613581358.024.6324.6c-Myc target genes involved in cell growth, apoptosis, and metabolism. C V DangMol Cell Biol19999858526No
244727161358.076.1138.1The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. W L Jorgensen, J Tirado-RivesJ Am Chem Soc198827557051Yes
244827151357.561.430.7Disruption of epithelial cell-matrix interactions induces apoptosis. S M Frisch, H FrancisJ Cell Biol19948106557Yes
244927151357.5108.9854.5A typology of reviews: an analysis of 14 review types and associated methodologies. Maria J Grant, Andrew BoothHealth Info Libr J200919490148No
245013571357.042.9543.0Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. A A GraceNeuroscience19911676137No
245127121356.0131.1165.6Glutathione peroxidase activity in selenium-deficient rat liver. R A Lawrence, R F BurkBiochem Biophys Res Commun1976971321Yes
245213561356.042.3942.4Glutathione metabolism and its selective modification. A MeisterJ Biol Chem19883053703No
245327111355.590.0145.0Social conditions as fundamental causes of disease. B G Link, J PhelanJ Health Soc Behav19957560851No
245427111355.555.1727.6Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. J M Kyriakis, J AvruchPhysiol Rev200111274345No
245513551355.064.764.7Molecular pathology of schizophrenia: more than one disease process? T J CrowBr Med J19806101544No
245613551355.037.7837.8Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. Felix KratzJ Control Release200818582981No
245727081354.070.8335.4Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis). S M Rogers, L BernatchezMol Ecol200515660930Yes
245827081354.083.4441.7Molecular and cellular insights into T cell exhaustion. E John Wherry, Makoto KurachiNat Rev Immunol201526205583No
245913531353.028.9629.0Codon usage and tRNA content in unicellular and multicellular organisms. T IkemuraMol Biol Evol19853916708No
246013531353.052.1252.1Blood gas calculator. J W SeveringhausJ Appl Physiol19665912737Yes
246113531353.056.3756.4Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation. Karimollah Hajian-TilakiCaspian J Intern Med201324009950No
246227041352.062.4331.2NF-kappa B: ten years after. P A Baeuerle, D BaltimoreCell19968858144No
246313521352.029.5829.6Transcriptional control of adipocyte formation. Stephen R FarmerCell Metab200617011499No
246427041352.0179.7889.9OrthoFinder: phylogenetic orthology inference for comparative genomics. David M Emms, Steven KellyGenome Biol201931727128Yes
246513511351.028.7128.7HIF-1: mediator of physiological and pathophysiological responses to hypoxia. G L SemenzaJ Appl Physiol (1985)200010749844No
246613511351.027.5427.5The many faces of macrophage activation. David M MosserJ Leukoc Biol200312554797No
246754041351.0127.231.8The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten SchwedeBioinformatics200616301204Yes
246827001350.091.2445.6Functional interactions between the gut microbiota and host metabolism. Valentina Tremaroli, Fredrik BäckhedNature201222972297No
246940491349.749.8716.6Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. D D Sabatini, K Bensch, R J BarrnettJ Cell Biol196313975866Yes
247013491349.034.634.6The biologic clock: the mitochondria? D HarmanJ Am Geriatr Soc19725016631Yes
247113491349.029.4929.5Measuring information transfer T SchreiberPhys Rev Lett200010991308Yes
247240461348.7156.0152.0Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Jack Bowden, George Davey Smith, Stephen BurgessInt J Epidemiol201526050253Yes
247313481348.041.7341.7Renin-angiotensin system: biochemistry and mechanisms of action. M J PeachPhysiol Rev1977191856No
247413481348.041.141.1Neurotransmitters and neuromodulators in the basal ganglia. A M GraybielTrends Neurosci19901695398No
247513481348.041.741.7Electrocatalyst approaches and challenges for automotive fuel cells. Mark K DebeNature201222678278Yes
247613481348.0110.02110.0Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Jonas F LudvigssonActa Paediatr202032202343Yes
247713471347.026.926.9Dimerization of cell surface receptors in signal transduction. C H HeldinCell19957834741No
247813471347.031.6131.6Non-Smad pathways in TGF-beta signaling. Ying E ZhangCell Res200919114990No
247913461346.020.4420.4A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. A M OlovnikovJ Theor Biol19734754905Yes
248013461346.025.9726.0Chromosomal translocations in human cancer. T H RabbittsNature19947969446No
248113451345.050.1450.1Letter: Grading of angina pectoris. L CampeauCirculation1976947585Yes
248240351345.0126.3642.1AChE-stained horizontal sections of the rat brain in stereotaxic coordinates. G Paxinos, C R Watson, P C EmsonJ Neurosci Methods19806110810Yes
248313451345.035.5135.5Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. S L FriedmanN Engl J Med19938502273No
248413451345.028.4328.4The enzymes, regulation, and genetics of bile acid synthesis. David W RussellAnnu Rev Biochem200312543708No
248567211344.2182.5536.5Transection of the oesophagus for bleeding oesophageal varices. R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R WilliamsBr J Surg19734541913Yes
248626881344.093.6146.8Total energy intake: implications for epidemiologic analyses. W Willett, M J StampferAm J Epidemiol19863521261No
248713441344.033.6433.6A molecular view of microbial diversity and the biosphere. N R PaceScience19979115194No
248813441344.025.8625.9Mechanisms of caspase activation and inhibition during apoptosis. Yigong ShiMol Cell200211931755No
248913441344.045.2145.2AmpC beta-lactamases. George A JacobyClin Microbiol Rev200919136439No
249053751343.8123.8431.0Quantitative monitoring of gene expression patterns with a complementary DNA microarray. M Schena, D Shalon, R W Davis, P O BrownScience19957569999Yes
249126861343.061.4630.7The RXR heterodimers and orphan receptors. D J Mangelsdorf, R M EvansCell19958521508No
249213431343.039.7639.8Circuitry and functional aspects of the insular lobe in primates including humans. J R AugustineBrain Res Brain Res Rev19968957561No
249313431343.00.00.0A simple ultraviolet spectrophotometric method for the determination of protein. W J WaddellJ Lab Clin Med195613346201Yes
249413431343.011.7911.8Immunological function of the thymus. J F MillerLancet196114474038Yes
249526851342.564.3932.2Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Subhra K Biswas, Alberto MantovaniNat Immunol201020856220No
249626851342.583.4741.7Tumor-associated macrophages: from mechanisms to therapy. Roy Noy, Jeffrey W PollardImmunity201425035953No
249713421342.041.9742.0Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Thomas HebererToxicol Lett200211988354Yes
249840261342.0139.6946.6Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Marina Colombo, Graça Raposo, Clotilde ThéryAnnu Rev Cell Dev Biol201425288114No
249913411341.036.0136.0Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. E B HunzikerOsteoarthritis Cartilage200212056848No
250013411341.027.9427.9Human natural killer cells. Michael A CaligiuriBlood200818650461No
250113411341.055.855.8Rhythms for Cognition: Communication through Coherence. Pascal FriesNeuron201526447583No
250226811340.590.0845.0Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. G J Miller, N E MillerLancet197546338Yes
250313401340.030.2430.2Physiological and molecular basis of thyroid hormone action. P M YenPhysiol Rev200111427693No
250413401340.034.0534.0Microbial influences in inflammatory bowel diseases. R Balfour SartorGastroenterology200818242222No
250526791339.571.8135.9Tumor metastasis: molecular insights and evolving paradigms. Scott Valastyan, Robert A WeinbergCell201122000009No
250613391339.059.5459.5Displaced proximal humeral fractures. I. Classification and evaluation. C S NeerJ Bone Joint Surg Am19705455339Yes
250726771338.559.7329.9A comparison of bayesian methods for haplotype reconstruction from population genotype data. Matthew Stephens, Peter DonnellyAm J Hum Genet200314574645Yes
250813381338.035.5735.6Fibronectin and its receptors. E RuoslahtiAnnu Rev Biochem19882972252No
250913381338.038.9238.9Osteoblast adhesion on biomaterials. K AnselmeBiomaterials200010711964No
251013381338.025.6225.6microRNAs: tiny regulators with great potential. V AmbrosCell200111779458No
251126761338.064.7232.4Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Uwe-Karsten Hanisch, Helmut KettenmannNat Neurosci200717965659No
251226741337.061.4830.7Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. G Blobel, B DobbersteinJ Cell Biol1975811671Yes
251313371337.028.5728.6The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. G B MorinCell19892805070Yes
251413371337.025.1425.1A modified procedure for lead staining of thin sections. G MillonigJ Biophys Biochem Cytol196114474176Yes
251513371337.023.023.0Protein modification by SUMO. Erica S JohnsonAnnu Rev Biochem200415189146No
251626741337.067.4633.7Therapeutic potential of resveratrol: the in vivo evidence. Joseph A Baur, David A SinclairNat Rev Drug Discov200616732220No
251713371337.038.0338.0Cytokinesis-block micronucleus cytome assay. Michael FenechNat Protoc200717546000Yes
251840101336.7100.6433.5LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. A C Wallace, R A Laskowski, J M ThorntonProtein Eng19957630882Yes
251913361336.034.9935.0The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. K KuwajimaProteins19892695928No
252013361336.063.1263.1Biological roles of glycans. Ajit VarkiGlycobiology201727558841No
252113351335.041.9542.0The phenomenon of the acute phase response. I KushnerAnn N Y Acad Sci19827046585No
252213351335.064.1364.1The clinical application of the biopsychosocial model. G L EngelAm J Psychiatry19807369396Yes
252326701335.054.1427.1Regulated portals of entry into the cell. Sean D Conner, Sandra L SchmidNature200312621426No
252426691334.573.1736.6A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. B G Durie, S E SalmonCancer19751182674Yes
252526691334.580.4340.2Further improvements in the plaque technique for detecting single antibody-forming cells. A J Cunningham, A SzenbergImmunology19685653817Yes
252613341334.044.6744.7Functional organization of central pathways regulating the cardiovascular system. R A DampneyPhysiol Rev19948171117No
252740011333.790.5530.2Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Witold Filipowicz, Suvendra N Bhattacharyya, Nahum SonenbergNat Rev Genet200818197166No
252813331333.045.3745.4Optimal foraging, the marginal value theorem. E L CharnovTheor Popul Biol19761273796Yes
252913331333.039.5839.6Classification of chronic viral hepatitis: a need for reassessment. P J ScheuerJ Hepatol19911808228No
253013331333.025.725.7Stereological principles for morphometry in electron microscopic cytology. E R WeibelInt Rev Cytol19694899604No
253113331333.047.0847.1Neuropeptide Y: complete amino acid sequence of the brain peptide. K TatemotoProc Natl Acad Sci U S A19826957876Yes
253213331333.027.2127.2Solving structures of protein complexes by molecular replacement with Phaser. Airlie J McCoyActa Crystallogr D Biol Crystallogr200717164524Yes
253313321332.033.2533.2Comparative physiology of salt and water stress. R. MunnsPlant Cell Environ200211841667Yes
253413321332.032.9132.9N-heterocyclic carbenes: a new concept in organometallic catalysis. Wolfgang A HerrmannAngew Chem Int Ed Engl200219750753Yes
253553271331.8117.4829.4Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J ThunN Engl J Med200312711737Yes
253639951331.7102.7234.2Cognitive and emotional influences in anterior cingulate cortex. G Bush, P Luu, M I PosnerTrends Cogn Sci200010827444Yes
253739941331.3107.3735.8Nitric oxide and peroxynitrite in health and disease. Pál Pacher, Joseph S Beckman, Lucas LiaudetPhysiol Rev200717237348No
253813301330.033.8233.8Thioredoxin and glutaredoxin systems. A HolmgrenJ Biol Chem19892668278No
253913301330.034.734.7The aryl hydrocarbon receptor complex. O HankinsonAnnu Rev Pharmacol Toxicol19957598497No
254013301330.040.7440.7Chronic disease management: what will it take to improve care for chronic illness? E H WagnerEff Clin Pract199810345255No
254113301330.023.4123.4SUMO: a history of modification. Ronald T HayMol Cell200515808504No
254239901330.087.7329.2Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Axel Nimmerjahn, Frank Kirchhoff, Fritjof HelmchenScience200515831717Yes
254326601330.061.5930.8Microenvironmental regulation of metastasis. Johanna A Joyce, Jeffrey W PollardNat Rev Cancer200919279573No
254413291329.030.2130.2Tumour necrosis factor and cancer. Frances BalkwillNat Rev Cancer200919343034No
254553151328.8131.2832.8Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. D W Cleveland, S G Fischer, M W Kirschner, U K LaemmliJ Biol Chem1977320200Yes
254626571328.5136.2268.1Sensitivity Analysis in Observational Research: Introducing the E-Value. Tyler J VanderWeele, Peng DingAnn Intern Med201728693043Yes
254713281328.00.00.0On the psychophysical law. S S StevensPsychol Rev195713441853Yes
254853111327.8228.6457.2Progressive statistics for studies in sports medicine and exercise science. William G Hopkins, Stephen W Marshall, Alan M Batterham, Juri HaninMed Sci Sports Exerc200919092709No
254926531326.555.7827.9Liver regeneration. G K Michalopoulos, M C DeFrancesScience19979082986No
255013261326.047.9948.0The life and times of the Enterococcus. B E MurrayClin Microbiol Rev19902404568No
255126521326.059.9130.0Cell cycle, CDKs and cancer: a changing paradigm. Marcos Malumbres, Mariano BarbacidNat Rev Cancer200919238148No
255226511325.558.2429.1Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Jane E Visvader, Geoffrey J LindemanNat Rev Cancer200818784658No
255313251325.050.750.7Free-radical mechanisms in tissue injury. T F SlaterBiochem J19846383353No
255413251325.030.0730.1Metastatic bone disease: clinical features, pathophysiology and treatment strategies. R E ColemanCancer Treat Rev200111417967No
255513251325.043.5243.5Phenylpropanoid biosynthesis. Thomas VogtMol Plant201020035037No
255613241324.013.1713.2Cellular resistance to infection. G B MackanessJ Exp Med196214467923Yes
255713241324.040.4940.5Nanobodies: natural single-domain antibodies. Serge MuyldermansAnnu Rev Biochem201323495938No
255826461323.060.2630.1Integrins and signal transduction pathways: the road taken. E A Clark, J S BruggeScience19957716514No
255913231323.050.6750.7Minority stress and mental health in gay men. I H MeyerJ Health Soc Behav19957738327Yes
256092561322.3231.3133.0Integrative genomics viewer. James T Robinson, Helga Thorvaldsdóttir, Wendy Winckler, Mitchell Guttman, Eric S Lander, Gad Getz, Jill P MesirovNat Biotechnol201121221095Yes
256113221322.029.8129.8Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. W D SniderCell19948205613No
256213221322.042.5942.6An application of prefrontal cortex function theory to cognitive aging. R L WestPsychol Bull19968831298No
256326441322.0106.0853.0Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Roel Nusse, Hans CleversCell201728575679No
256426421321.046.5423.3Rab proteins as membrane organizers. M Zerial, H McBrideNat Rev Mol Cell Biol200111252952No
256513211321.00.00.0The anterior approach for removal of ruptured cervical disks. R B ClowardJ Neurosurg195813599052Yes
256626411320.583.3841.7DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI. Yan Chao-Gan, Zang Yu-FengFront Syst Neurosci201020577591Yes
256739601320.097.4132.5The p53 tumour suppressor gene. A J Levine, J Momand, C A FinlayNature19912046748No
256826401320.0100.6150.3Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. E Engvall, P PerlmannJ Immunol19724113792Yes
256913201320.031.6131.6Apoptosis in cancer therapy: crossing the threshold. D E FisherCell19948069905No
257013201320.022.9623.0Regulatory T cells: key controllers of immunologic self-tolerance. S SakaguchiCell200010850488No
257126381319.0123.1761.6Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. J M Tanner, R H WhitehouseArch Dis Child1976952550Yes
257239571319.0140.8947.0A new method for off-line removal of ocular artifact. G Gratton, M G Coles, E DonchinElectroencephalogr Clin Neurophysiol19836187540Yes
257313191319.038.3938.4Endometriosis. Serdar E BulunN Engl J Med200919144942No
257413191319.028.2628.3Mechanisms of foxp3+ T regulatory cell-mediated suppression. Ethan M ShevachImmunity200919464986No
257513191319.032.3432.3Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. G L SemenzaOncogene201019946328No
257626371318.5100.9450.5Malondialdehyde determination as index of lipid peroxidation. H H Draper, M HadleyMethods Enzymol19902233309Yes
257713181318.035.1735.2Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Arnold I CaplanJ Cell Physiol200717620285No
257839531317.791.5230.5Tissue cells feel and respond to the stiffness of their substrate. Dennis E Discher, Paul Janmey, Yu-Li WangScience200516293750No
257926351317.548.9224.5New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. R D Gietz, A SuginoGene19883073106Yes
258039521317.383.928.0A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. R Medzhitov, P Preston-Hurlburt, C A JanewayNature19979237759Yes
258113171317.023.0323.0Clonal selection and learning in the antibody system. K RajewskyNature19968657279No
258213171317.055.355.3The Laboratory Rat: Relating Its Age With Human's. Pallav SenguptaInt J Prev Med201323930179Yes
258379001316.7199.4233.2Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat RoblesBioinformatics200516081474Yes
258413161316.035.5235.5Polycystic ovary syndrome. David A EhrmannN Engl J Med200515788499No
258513161316.038.8238.8Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Thomas GrobnerNephrol Dial Transplant200616431890Yes
258639471315.780.8627.0Calcium signalling: dynamics, homeostasis and remodelling. Michael J Berridge, Martin D Bootman, H Llewelyn RoderickNat Rev Mol Cell Biol200312838335No
258713151315.044.5544.5Carnitine--metabolism and functions. J BremerPhysiol Rev19836361812No
258813151315.054.6154.6Error in medicine. L L LeapeJAMA19947503827Yes
258952581314.5123.6430.9Improved prediction of signal peptides: SignalP 3.0. Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren BrunakJ Mol Biol200415223320Yes
259026281314.068.034.0Apoptosis, oncosis, and necrosis. An overview of cell death. G Majno, I JorisAm J Pathol19957856735No
259126281314.070.235.1Chlorophyll fluorescence--a practical guide. K Maxwell, G N JohnsonJ Exp Bot200010938857No
259213141314.027.8927.9Prediction of protein cellular attributes using pseudo-amino acid composition. K C ChouProteins200111288174Yes
259313141314.028.7428.7Long-term potentiation and memory. M A LynchPhysiol Rev200414715912No
259439411313.793.2431.1Functional porous coordination polymers. Susumu Kitagawa, Ryo Kitaura, Shin-ichiro NoroAngew Chem Int Ed Engl200415114565Yes
259539401313.3101.9234.0Bacterial biofilms: from the natural environment to infectious diseases. Luanne Hall-Stoodley, J William Costerton, Paul StoodleyNat Rev Microbiol200415040259No
259613131313.016.9817.0Disconnexion syndromes in animals and man. I. N GeschwindBrain19655318481No
259713131313.033.9534.0Supported membranes: scientific and practical applications. E SackmannScience19968539599No
259813131313.033.6833.7Psychological and neural mechanisms of the affective dimension of pain. D D PriceScience200010846154No
259913131313.069.3869.4ROS Are Good. Ron MittlerTrends Plant Sci201727666517No
260026251312.555.8327.9The canonical Notch signaling pathway: unfolding the activation mechanism. Raphael Kopan, Maria Xenia G IlaganCell200919379690No
260165621312.4123.5524.7Crystal structure of the nucleosome core particle at 2.8 A resolution. K Luger, A W Mäder, R K Richmond, D F Sargent, T J RichmondNature19979305837Yes
260213121312.037.337.3The matrix-degrading metalloproteinases. L M MatrisianBioessays19921445287No
260313121312.073.3173.3A comparison of canal preparations in straight and curved root canals. S W SchneiderOral Surg Oral Med Oral Pathol19715284110Yes
260413121312.033.1233.1Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. R M SapolskyArch Gen Psychiatry200011015810No
260539361312.0132.4444.1Job burnout. C Maslach, W B Schaufeli, M P LeiterAnnu Rev Psychol200111148311Yes
260626231311.556.5728.3Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. M Zuker, P StieglerNucleic Acids Res19816163133Yes
260752451311.2104.5526.1Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. D D Sarbassov, David A Guertin, Siraj M Ali, David M SabatiniScience200515718470Yes
260813111311.039.9339.9Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. W W DouglasBr J Pharmacol19684882190No
260913101310.037.3837.4Qinghaosu (artemisinin): an antimalarial drug from China. D L KlaymanScience19853887571No
261013101310.027.6927.7Double identity for proteins of the Bcl-2 family. J C ReedNature19979194558No
261126201310.062.4731.2C-reactive protein: a critical update. Mark B Pepys, Gideon M HirschfieldJ Clin Invest200312813013No
261213101310.00.00.0Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. P F ScholanderJ Biol Chem194720281644Yes
261313101310.040.8440.8Thermal properties of graphene and nanostructured carbon materials. Alexander A BalandinNat Mater201121778997Yes
261452401310.0257.1664.3Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. Xiang Wan, Wenqian Wang, Jiming Liu, Tiejun TongBMC Med Res Methodol201425524443Yes
261526191309.547.6823.8Immunization of dissociated spleen cell cultures from normal mice. R I Mishell, R W DuttonJ Exp Med19676034749Yes
261613091309.034.6234.6Phylogenies from molecular sequences: inference and reliability. J FelsensteinAnnu Rev Genet19883071258No
261713091309.069.8869.9Psychosocial resilience and protective mechanisms. Michael RutterAm J Orthopsychiatry19873303954No
261813091309.048.8248.8Microtiter dish biofilm formation assay. George A O'TooleJ Vis Exp201121307833Yes
261913091309.0109.8109.8COVID-19 and African Americans. Clyde W YancyJAMA202032293639Yes
262026171308.540.6520.3Functions of lysosomes. C De Duve, R WattiauxAnnu Rev Physiol19665322983No
262126161308.059.429.7Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. E Y Chen, P H SeeburgDNA19853996185Yes
262226161308.057.3528.7Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. S W Hell, J WichmannOpt Lett199419844443Yes
262326151307.575.1437.6Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. Aluísio J D Barros, Vânia N HirakataBMC Med Res Methodol200314567763Yes
262452291307.2210.4752.6QUAST: quality assessment tool for genome assemblies. Alexey Gurevich, Vladislav Saveliev, Nikolay Vyahhi, Glenn TeslerBioinformatics201323422339Yes
262513071307.024.4524.4Antigen-specific interaction between T and B cells. A LanzavecchiaNature19853157869Yes
262626141307.040.2520.1The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. J Shine, L DalgarnoProc Natl Acad Sci U S A19744598299Yes
262713071307.00.00.0A quantitative immunochemical measure of the primary interaction between I BSA and antibody. R S FarrJ Infect Dis195813611294Yes
262813071307.041.8341.8How stigma interferes with mental health care. Patrick CorriganAm Psychol200415491256Yes
262913061306.035.6435.6The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. R G GerrityAm J Pathol19817234961Yes
263013061306.037.8537.9Species concepts and species delimitation. Kevin De QueirozSyst Biol200718027281Yes
263113061306.035.735.7Regulation of glutathione synthesis. Shelly C LuMol Aspects Med200918601945No
263226081304.076.8638.4Prediction of the secondary structure of proteins from their amino acid sequence. P Y Chou, G D FasmanAdv Enzymol Relat Areas Mol Biol1978364941No
263313041304.033.8133.8The sympathetic control of blood pressure. Patrice G GuyenetNat Rev Neurosci200616760914No
263413041304.027.1427.1Neuroligins and neurexins link synaptic function to cognitive disease. Thomas C SüdhofNature200818923512No
263513041304.071.9972.0DLS and zeta potential - What they are and what they are not? Sourav BhattacharjeeJ Control Release201627297779No
263678231303.8195.5532.6An obesity-associated gut microbiome with increased capacity for energy harvest. Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I GordonNature200617183312Yes
263726071303.538.2519.1Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. J E Sulston, H R HorvitzDev Biol1977838129Yes
263826071303.50.00.0Construct validity in psychological tests. L J Cronbach, P E MeehlPsychol Bull195513245896Yes
263926061303.077.3538.7Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Christine Vogel, Edward M MarcotteNat Rev Genet201222411467No
264013021302.031.8731.9Surrogate endpoints in clinical trials: definition and operational criteria. R L PrenticeStat Med19892727467Yes
264113021302.044.5844.6The theoretical bases of indirect calorimetry: a review. E FerranniniMetabolism19883278194No
264213021302.021.721.7Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. W D HamiltonScience19676021675Yes
264339061302.087.8129.3Photodynamic therapy for cancer. Dennis E J G J Dolmans, Dai Fukumura, Rakesh K JainNat Rev Cancer200312724736No
264426021301.043.3221.7Genetic transformation of Drosophila with transposable element vectors. G M Rubin, A C SpradlingScience19826289436Yes
264513011301.042.0542.0The epidemiology of adult obstructive sleep apnea. Naresh M PunjabiProc Am Thorac Soc200818250205No
264613011301.037.0637.1Subcutaneous and visceral adipose tissue: structural and functional differences. M Mohsen IbrahimObes Rev201019656312No
264713011301.00.00.0Limitations of the application of fourfold table analysis to hospital data. J BerksonBiometrics194621001024Yes
264813011301.044.7144.7PaDEL-descriptor: an open source software to calculate molecular descriptors and fingerprints. Chun Wei YapJ Comput Chem201121425294Yes
264965041300.8159.8832.0Enzymatic determination of total serum cholesterol. C C Allain, L S Poon, C S Chan, W Richmond, P C FuClin Chem19744818200Yes
265013001300.032.0132.0Overview of general physiologic features and functions of vitamin D. Hector F DeLucaAm J Clin Nutr200415585789No
265138991299.791.2530.4Evolution and functions of long noncoding RNAs. Chris P Ponting, Peter L Oliver, Wolf ReikCell200919239885No
265225981299.0161.5480.8Facial nerve grading system. J W House, D E BrackmannOtolaryngol Head Neck Surg19853921901Yes
265312991299.029.7129.7The path to ubiquitous and low-cost organic electronic appliances on plastic. Stephen R ForrestNature200415118718Yes
265412981298.030.0930.1Pathways of oxidative damage. James A ImlayAnnu Rev Microbiol200314527285No
265512981298.032.932.9Pain and emotion interactions in subregions of the cingulate gyrus. Brent A VogtNat Rev Neurosci200515995724No
265625961298.0105.7152.9The Warburg Effect: How Does it Benefit Cancer Cells? Maria V Liberti, Jason W LocasaleTrends Biochem Sci201626778478No
265712971297.031.0431.0Receptors for epidermal growth factor and other polypeptide mitogens. G CarpenterAnnu Rev Biochem19873039909No
265812971297.028.4528.4Liver fibrosis -- from bench to bedside. Scott L FriedmanJ Hepatol200312591185No
265951841296.0114.0728.5A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry SharplessAngew Chem Int Ed Engl200212203546Yes
266012961296.040.0240.0Evaluating the quality of medical care. 1966. Avedis DonabedianMilbank Q200516279964No
266112961296.038.8638.9Persister cells. Kim LewisAnnu Rev Microbiol201020528688No
266238861295.3127.3942.5Rehospitalizations among patients in the Medicare fee-for-service program. Stephen F Jencks, Mark V Williams, Eric A ColemanN Engl J Med200919339721Yes
266325901295.082.8241.4Epidermal growth factor. G Carpenter, S CohenAnnu Rev Biochem1979382984No
266412951295.035.0635.1Neural simulation of action: a unifying mechanism for motor cognition. M JeannerodNeuroimage200111373140No
266525901295.00.00.0Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. H A Edmondson, P E SteinerCancer195413160935Yes
266625901295.067.4833.7Integrins in cancer: biological implications and therapeutic opportunities. Jay S Desgrosellier, David A ChereshNat Rev Cancer201020029421No
266712941294.031.1431.1Papillomavirus infections--a major cause of human cancers. H zur HausenBiochim Biophys Acta19968876633No
266825881294.061.6330.8Multipoint quantitative-trait linkage analysis in general pedigrees. L Almasy, J BlangeroAm J Hum Genet19989545414Yes
266912941294.023.4123.4CD95's deadly mission in the immune system. P H KrammerNature200011048730No
267012941294.027.227.2The stem-cell niche as an entity of action. David T ScaddenNature200616810242No
267112941294.00.00.0On the local reactions of the arterial wall to changes of internal pressure. W M BaylissJ Physiol190216992618Yes
267225871293.564.3132.2Interneurons of the hippocampus. T F Freund, G BuzsákiHippocampus19968915675No
267312931293.029.5129.5Oxyradicals and DNA damage. L J MarnettCarcinogenesis200010688856No
267412931293.030.2630.3Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Hiroshi TakayanagiNat Rev Immunol200717380158No
267525851292.555.6227.8Mitochondrial control of cell death. G Kroemer, J C ReedNat Med200010802706No
267612921292.041.441.4Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. J H LuftAnat Rec19714108333Yes
267712921292.061.4161.4Cardiovascular and renal actions of dopamine: potential clinical applications. L I GoldbergPharmacol Rev19724554480No
267825841292.059.8429.9Quorum sensing in bacteria. M B Miller, B L BasslerAnnu Rev Microbiol200111544353No
267912911291.042.4442.4Electrophoretic separation of plasma lipoproteins in agarose gel. R P NobleJ Lipid Res19684176473Yes
268012911291.029.5629.6The prefrontal cortex and cognitive control. E K MillerNat Rev Neurosci200011252769No
268112911291.084.4784.5SARS-CoV-2 vaccines in development. Florian KrammerNature202032967006No
268212901290.022.5722.6The molecular motor toolbox for intracellular transport. Ronald D ValeCell200312600311No
268312901290.00.00.0Agammaglobulinemia. O C BrutonPediatrics195214929630Yes
268425791289.571.2335.6What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? K C Berridge, T E RobinsonBrain Res Brain Res Rev19989858756No
268525791289.569.4234.7Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Taro Kawai, Shizuo AkiraImmunity201121616434No
268625781289.057.3628.7The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. P M Sharp, W H LiNucleic Acids Res19873547335Yes
268725781289.0130.6265.3A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. M Roland, R MorrisSpine (Phila Pa 1976)19836222486Yes
268812891289.034.2534.2The biochemistry and medical significance of the flavonoids. Bent H HavsteenPharmacol Ther200212453566No
268938671289.0109.3136.4The Patient Health Questionnaire-2: validity of a two-item depression screener. Kurt Kroenke, Robert L Spitzer, Janet B W WilliamsMed Care200314583691Yes
269012891289.023.9423.9Mobile elements: drivers of genome evolution. Haig H KazazianScience200415016989No
269112891289.029.1829.2Refined structure of the nicotinic acetylcholine receptor at 4A resolution. Nigel UnwinJ Mol Biol200515701510Yes
269225771288.559.0129.5Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Kornelia Polyak, Robert A WeinbergNat Rev Cancer200919262571No
269312881288.036.6336.6A Wilcoxon-type test for trend. J CuzickStat Med19853992076Yes
269412881288.037.3537.4Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. A BöyumScand J Clin Lab Invest Suppl19684179066Yes
269512881288.045.3845.4Plasma perspective on strong field multiphoton ionization. P B CorkumPhys Rev Lett199310054556Yes
2696141671287.9381.5434.7The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J RoccellaJAMA200312748199No
269712871287.031.7231.7The mitochondrial electron transport and oxidative phosphorylation system. Y HatefiAnnu Rev Biochem19852862839No
269812871287.010.6410.6Metabolic stability and epigenesis in randomly constructed genetic nets. S A KauffmanJ Theor Biol19695803332Yes
269912871287.026.9126.9Recognition and processing of ubiquitin-protein conjugates by the proteasome. Daniel FinleyAnnu Rev Biochem200919489727No
270025731286.588.2444.1Regulatory sequences involved in the promotion and termination of RNA transcription. M Rosenberg, D CourtAnnu Rev Genet197994251No
270125731286.582.4141.2The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. Julie D Henry, John R CrawfordBr J Clin Psychol200516004657Yes
270251451286.2184.7846.2The chemistry and applications of metal-organic frameworks. Hiroyasu Furukawa, Kyle E Cordova, Michael O'Keeffe, Omar M YaghiScience201323990564Yes
270312861286.038.9238.9Diversity and ubiquity of K channels. B RudyNeuroscience19882457185No
270425721286.082.341.1Oxidative mechanisms in the toxicity of metal ions. S J Stohs, D BagchiFree Radic Biol Med19957744317No
270538581286.097.6132.5Atomic force microscope. G Binnig, C F Quate, C GerberPhys Rev Lett198610033323Yes
270625711285.555.0127.5The pathophysiology of mitochondrial cell death. Douglas R Green, Guido KroemerScience200415286356No
270725711285.594.5447.3Liposomal drug delivery systems: from concept to clinical applications. Theresa M Allen, Pieter R CullisAdv Drug Deliv Rev201323036225No
270812851285.046.9547.0Substance P. B PernowPharmacol Rev19836196797No
270912851285.030.4130.4Lymphokine production by human T cells in disease states. S RomagnaniAnnu Rev Immunol19948011282No
271025701285.045.9823.0DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Christopher J Bakkenist, Michael B KastanNature200312556884Yes
271112851285.027.3127.3Sustainable hydrogen production. John A TurnerScience200415310892Yes
271225691284.546.7323.4Live or let die: the cell's response to p53. Karen H Vousden, Xin LuNat Rev Cancer200212154352No
271312841284.034.6334.6How brains beware: neural mechanisms of emotional attention. Patrik VuilleumierTrends Cogn Sci200516289871Yes
271412831283.056.1756.2Biomaterial-centered infection: microbial adhesion versus tissue integration. A G GristinaScience19873629258Yes
271525661283.063.4331.7Neuronal plasticity: increasing the gain in pain. C J Woolf, M W SalterScience200010846153No
271612831283.055.9656.0Canadian Diabetes Association 2013 clinical practice guidelines for the prevention and management of diabetes in Canada. Introduction. Alice Y Y ChengCan J Diabetes201324070926No
271725641282.060.8630.4Production of single-stranded plasmid DNA. J Vieira, J MessingMethods Enzymol19873323803Yes
271812821282.034.134.1Levels of racism: a theoretic framework and a gardener's tale. C P JonesAm J Public Health200010936998Yes
271925631281.523.7611.9Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Altman, G D DasJ Comp Neurol19655861717Yes
272012811281.039.039.0Understanding diagnostic tests 3: Receiver operating characteristic curves. Anthony K AkobengActa Paediatr200717376185No
272112811281.031.9131.9TNF-mediated inflammatory disease. J R BradleyJ Pathol200818161752No
272225611280.565.7332.9Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. J A Ledbetter, L A HerzenbergImmunol Rev1979398327No
272325611280.589.3744.7Surgical risk as related to time of intervention in the repair of intracranial aneurysms. W E Hunt, R M HessJ Neurosurg19685635959Yes
272425601280.097.4448.7Cronbach's alpha. J M Bland, D G AltmanBMJ19979055718Yes
272589591279.9251.9236.0Cancer statistics, 2008. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J ThunCA Cancer J Clin200818287387Yes
272625591279.552.6926.3The molecular biology of axon guidance. M Tessier-Lavigne, C S GoodmanScience19968895455No
272712791279.043.1143.1Density matrix formulation for quantum renormalization groups. S R WhitePhys Rev Lett199210046608Yes
272812791279.032.1132.1Plasmonics: merging photonics and electronics at nanoscale dimensions. Ekmel OzbayScience200616410515Yes
272912791279.040.5840.6Function and information content of DNA methylation. Dirk SchübelerNature201525592537No
273038341278.091.1530.4Dystrophin: the protein product of the Duchenne muscular dystrophy locus. E P Hoffman, R H Brown, L M KunkelCell19873319190Yes
273112781278.042.4742.5Bee and wasp venoms. E HabermannScience19724113805No
273225561278.062.7531.4The free radical theory of aging matures. K B Beckman, B N AmesPhysiol Rev19989562038No
273325561278.051.9426.0Tumorigenesis and the angiogenic switch. Gabriele Bergers, Laura E BenjaminNat Rev Cancer200312778130No
273412781278.037.4837.5Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. Louis B RiceJ Infect Dis200818419525No
273512781278.036.1736.2Deconvoluting the context-dependent role for autophagy in cancer. Eileen WhiteNat Rev Cancer201222534666No
273663861277.2249.0249.8The Phyre2 web portal for protein modeling, prediction and analysis. Lawrence A Kelley, Stefans Mezulis, Christopher M Yates, Mark N Wass, Michael J E SternbergNat Protoc201525950237Yes
273712771277.060.6860.7New norms of upper limb fat and muscle areas for assessment of nutritional status. A R FrisanchoAm J Clin Nutr19816975564Yes
273812771277.021.7121.7Cancer susceptibility and the functions of BRCA1 and BRCA2. Ashok R VenkitaramanCell200211832208No
273912771277.035.2935.3Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. P VestergaardOsteoporos Int200717068657No
274025531276.5226.15113.1Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. R B Gustilo, J T AndersonJ Bone Joint Surg Am1976773941Yes
274112761276.039.3139.3Somatostatin. S ReichlinN Engl J Med19836139753No
274212751275.033.5233.5Persister cells, dormancy and infectious disease. Kim LewisNat Rev Microbiol200717143318No
274312751275.00.00.0Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. H M KalckarJ Biol Chem194720285041Yes
274425491274.561.4930.7Drug delivery systems: entering the mainstream. Theresa M Allen, Pieter R CullisScience200415031496Yes
274538221274.0170.7856.9In search of how people change. Applications to addictive behaviors. J O Prochaska, C C DiClemente, J C NorcrossAm Psychol19921329589Yes
274625481274.048.9224.5Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. M Fried, D M CrothersNucleic Acids Res19816275366Yes
274725481274.0156.2578.1A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. E S Grood, W J SuntayJ Biomech Eng19836865355Yes
274825471273.578.939.5Modeling and comparison of dissolution profiles. P Costa, J M Sousa LoboEur J Pharm Sci200111297896No
274925461273.068.6934.3Establishment and characterization of a human histiocytic lymphoma cell line (U-937). C Sundström, K NilssonInt J Cancer1976178611Yes
275012731273.028.9829.0Chemistry and biology of the immunophilins and their immunosuppressive ligands. S L SchreiberScience19911702904No
275112731273.026.6426.6Nucleic acid junctions and lattices. N C SeemanJ Theor Biol19826188926Yes
275212731273.036.1536.1Plant productivity and environment. J S BoyerScience198217808529Yes
275312731273.00.00.0The antidiuretic hormone and the factors which determine its release. E B VerneyProc R Soc Lond B Biol Sci194718918876Yes
275425441272.067.0433.5Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Ajay Kumar Gupta, Mona GuptaBiomaterials200515626447No
275512721272.031.2131.2Hydrogen sulphide and its therapeutic potential. Csaba SzabóNat Rev Drug Discov200717948022No
275612711271.028.728.7Evaluating medication effects outside of clinical trials: new-user designs. Wayne A RayAm J Epidemiol200314585769Yes
275712711271.040.9941.0Photoplethysmography and its application in clinical physiological measurement. John AllenPhysiol Meas200717322588No
275825401270.076.0838.0An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Sun Ho Kim, Jin Mo ChungPain19921333581Yes
275912701270.025.5725.6Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. R H SchwartzCell19921335362No
276012701270.030.1830.2Somatostatin and its receptor family. Y C PatelFront Neuroendocrinol199910433861No
276112701270.034.3634.4Internal models for motor control and trajectory planning. M KawatoCurr Opin Neurobiol199910607637No
276238091269.7103.4234.5Molecular characterization of a peripheral receptor for cannabinoids. S Munro, K L Thomas, M Abu-ShaarNature19937689702Yes
276325391269.550.4625.2A rapid, sensitive, and specific method for the determination of protein in dilute solution. W Schaffner, C WeissmannAnal Biochem19734128882Yes
276438081269.3141.8847.3Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis. Christopher K Prier, Danica A Rankic, David W C MacMillanChem Rev201323509883No
276525371268.557.1528.6Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. D A Brown, J K RoseCell19921531449Yes
276625361268.049.0824.5CpG islands in vertebrate genomes. M Gardiner-Garden, M FrommerJ Mol Biol19873656447Yes
276712681268.031.3331.3Optimal experimental design for event-related fMRI. A M DaleHum Brain Mapp199910524601Yes
276825361268.066.6433.3Epidemiology and outcomes of osteoporotic fractures. Steven R Cummings, L Joseph MeltonLancet200212049882No
276925361268.064.0432.0An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Gary Aston-Jones, Jonathan D CohenAnnu Rev Neurosci200516022602No
277012671267.031.4431.4Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. J DeisenhoferBiochemistry19817236608Yes
277112661266.028.3128.3Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. T A SpringerAnnu Rev Physiol19957778885No
277237981266.073.2224.4Exosomes: composition, biogenesis and function. Clotilde Théry, Laurence Zitvogel, Sebastian AmigorenaNat Rev Immunol200212154376No
277312661266.00.00.0A simple objective technique for measuring flexibility in thinking. E A BergJ Gen Psychol194818889466Yes
277412661266.034.9835.0T follicular helper cell differentiation, function, and roles in disease. Shane CrottyImmunity201425367570No
277550631265.8116.7429.2Autophagy fights disease through cellular self-digestion. Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J KlionskyNature200818305538No
277637951265.0112.0837.4The functional anatomy of basal ganglia disorders. R L Albin, A B Young, J B PenneyTrends Neurosci19892479133No
277763251265.0152.8230.6Jalview Version 2--a multiple sequence alignment editor and analysis workbench. Andrew M Waterhouse, James B Procter, David M A Martin, Michèle Clamp, Geoffrey J BartonBioinformatics200919151095Yes
277825291264.513.326.7Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. G J Todaro, H GreenJ Cell Biol196313985244Yes
277975861264.3217.7836.3Free radicals and antioxidants in normal physiological functions and human disease. Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua TelserInt J Biochem Cell Biol200716978905No
278012641264.031.5731.6The effective period of preventive antibiotic action in experimental incisions and dermal lesions. J F BurkeSurgery196116722001Yes
278137911263.790.1830.1Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Christopher R Genovese, Nicole A Lazar, Thomas NicholsNeuroimage200211906227Yes
2782138981263.5355.9932.4Frailty in older adults: evidence for a phenotype. L P Fried, C M Tangen, J Walston, A B Newman, C Hirsch, J Gottdiener, T Seeman, R Tracy, W J Kop, G Burke, M A McBurnieJ Gerontol A Biol Sci Med Sci200111253156Yes
278312631263.032.1532.1Rapid evolution of a protein in vitro by DNA shuffling. W P StemmerNature19948047147Yes
278425251262.567.333.6Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. J L Weber, P E MayAm J Hum Genet19892916582Yes
278550491262.2183.645.9Near-optimal probabilistic RNA-seq quantification. Nicolas L Bray, Harold Pimentel, Páll Melsted, Lior PachterNat Biotechnol201627043002Yes
278612621262.026.7826.8Assortative mixing in networks. M E J NewmanPhys Rev Lett200212443515Yes
278725241262.085.4342.7Factors affecting wound healing. S Guo, L A DipietroJ Dent Res201020139336No
278837851261.7118.2639.4MR diffusion tensor spectroscopy and imaging. P J Basser, J Mattiello, D LeBihanBiophys J19948130344Yes
278925231261.550.9425.5ERBB receptors and cancer: the complexity of targeted inhibitors. Nancy E Hynes, Heidi A LaneNat Rev Cancer200515864276No
279012611261.030.3930.4Short-term synaptic plasticity. R S ZuckerAnnu Rev Neurosci19892648947No
279112611261.036.1536.1Peptide antibiotics and their role in innate immunity. H G BomanAnnu Rev Immunol19957612236No
279212611261.025.9826.0Signal transduction via the MAP kinases: proceed at your own RSK. J BlenisProc Natl Acad Sci U S A19938392180No
279325221261.044.2422.1The DNA damage response: putting checkpoints in perspective. B B Zhou, S J ElledgeNature200011100718No
279412611261.053.0253.0Inflammation, metaflammation and immunometabolic disorders. Gökhan S HotamisligilNature201728179656No
279512601260.033.8533.9Signaling through phosphatidylcholine breakdown. J H ExtonJ Biol Chem19902104616No
279612601260.014.0714.1A restriction point for control of normal animal cell proliferation. A B PardeeProc Natl Acad Sci U S A19744524638Yes
279725201260.055.9628.0Can the pharmaceutical industry reduce attrition rates? Ismail Kola, John LandisNat Rev Drug Discov200415286737No
279812591259.063.2663.3Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. Anna Maria CarlssonPain19836602967Yes
279912591259.026.7726.8Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nicholas C DenkoNat Rev Cancer200819143055No
280012591259.053.653.6Environmentally induced oxidative stress in aquatic animals. Volodymyr I LushchakAquat Toxicol201121074869No
280150321258.0144.7636.2Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Weidner, J P Semple, W R Welch, J FolkmanN Engl J Med19911701519Yes
280212581258.025.7425.7SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. S V EvansJ Mol Graph19938347566Yes
280312581258.025.6925.7Endocytosis and molecular sorting. I MellmanAnnu Rev Cell Dev Biol19968970738No
280412581258.029.529.5Reactive oxygen radicals in signaling and damage in the ischemic brain. P H ChanJ Cereb Blood Flow Metab200111149664No
280512581258.041.9742.0Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. Rui WangPhysiol Rev201222535897No
280612571257.034.6534.6Tumor angiogenesis. J FolkmanAdv Cancer Res19852581424No
280712571257.034.8934.9The effects of stressful life events on depression. R C KesslerAnnu Rev Psychol19979046559No
280825141257.061.7430.9Pharmacology and functions of metabotropic glutamate receptors. P J Conn, J P PinAnnu Rev Pharmacol Toxicol19979131252No
280925141257.047.0823.5The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. T Maehama, J E DixonJ Biol Chem19989593664Yes
281012571257.027.1727.2S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. R DonatoInt J Biochem Cell Biol200111390274No
281112571257.023.623.6ChIP-seq: advantages and challenges of a maturing technology. Peter J ParkNat Rev Genet200919736561No
281212571257.046.8946.9Glutathione synthesis. Shelly C LuBiochim Biophys Acta201322995213No
281337701256.7111.5937.2Health benefits of physical activity: the evidence. Darren E R Warburton, Crystal Whitney Nicol, Shannon S D BredinCMAJ200616534088No
281412561256.046.646.6Experience from a multicentre stroke register: a preliminary report. S HatanoBull World Health Organ19761088404Yes
281525121256.073.0936.5Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. J I Morgan, T CurranAnnu Rev Neurosci19911903243No
281612561256.042.8942.9Inhibition and facilitation of nucleic acid amplification. I G WilsonAppl Environ Microbiol19979327537No
281712561256.026.7326.7Molecular physiology of low-voltage-activated t-type calcium channels. Edward Perez-ReyesPhysiol Rev200312506128No
281812561256.00.00.0The relation of the trail making test to organic brain damage. R M ReitanJ Consult Psychol195513263471Yes
281925111255.548.7324.4Proliferation, cell cycle and apoptosis in cancer. G I Evan, K H VousdenNature200111357141No
282025111255.587.8743.9Nitric oxide synthases: regulation and function. Ulrich Förstermann, William C SessaEur Heart J201221890489No
282125111255.598.0249.0Unique features of long non-coding RNA biogenesis and function. Jeffrey J Quinn, Howard Y ChangNat Rev Genet201626666209No
282212551255.032.2232.2Drug delivery and targeting. R LangerNature19989579855No
282312551255.035.3735.4Targeting recovery: priorities of the spinal cord-injured population. Kim D AndersonJ Neurotrauma200415672628Yes
282487821254.6259.7137.1Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E MarshStroke19937678184Yes
282550181254.5104.9826.2Interleukin-10 and the interleukin-10 receptor. K W Moore, R de Waal Malefyt, R L Coffman, A O'GarraAnnu Rev Immunol200111244051No
282625091254.562.9531.5Epidemiology of Parkinson's disease. Lonneke M L de Lau, Monique M B BretelerLancet Neurol200616713924No
282712541254.030.5230.5Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. P KuzmicAnal Biochem19968660575Yes
282812541254.028.628.6Optical microcavities. Kerry J VahalaNature200312917698Yes
282925081254.048.724.4Gene silencing in cancer in association with promoter hypermethylation. James G Herman, Stephen B BaylinN Engl J Med200314627790No
283025081254.088.2444.1Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. John F Cryan, Timothy G DinanNat Rev Neurosci201222968153No
283125071253.561.5630.8Hydrogels for tissue engineering. K Y Lee, D J MooneyChem Rev200111710233No
283212531253.032.3532.4Strategy and tactics in protein chemistry. B S HartleyBiochem J19704923920No
283337591253.0112.4337.5Oxidants, antioxidants, and the degenerative diseases of aging. B N Ames, M K Shigenaga, T M HagenProc Natl Acad Sci U S A19938367443No
283412531253.030.3930.4Primate anterior cingulate cortex: where motor control, drive and cognition interface. T PausNat Rev Neurosci200111389475No
283512531253.045.6445.6Energy metabolism in the liver. Liangyou RuiCompr Physiol201424692138No
2836137771252.5328.0429.8New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G GwytherJ Natl Cancer Inst200010655437No
283725051252.568.5634.3The cognitive control of emotion. Kevin N Ochsner, James J GrossTrends Cogn Sci200515866151No
283862621252.4334.9767.0ModelFinder: fast model selection for accurate phylogenetic estimates. Subha Kalyaanamoorthy, Bui Quang Minh, Thomas K F Wong, Arndt von Haeseler, Lars S JermiinNat Methods201728481363Yes
283912521252.082.6882.7The problem of rigor in qualitative research. M SandelowskiANS Adv Nurs Sci19863083765Yes
284012521252.024.624.6Structure and function of intercellular junctions. L A StaehelinInt Rev Cytol19744611943No
284112521252.042.242.2Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. R LotanBiochim Biophys Acta19806989400No
284212521252.031.4931.5Apoptosis. J J CohenImmunol Today19938466628No
284312521252.027.7827.8Neurobiology of Pavlovian fear conditioning. S MarenAnnu Rev Neurosci200111520922No
284412521252.025.9425.9The roles of intracellular protein-degradation pathways in neurodegeneration. David C RubinszteinNature200617051204No
284512521252.033.833.8Infection in solid-organ transplant recipients. Jay A FishmanN Engl J Med200718094380No
284637551251.7104.034.7Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Günter Oberdörster, Eva Oberdörster, Jan OberdörsterEnviron Health Perspect200516002369No
284725031251.557.8828.9DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. S Tabor, C C RichardsonProc Natl Acad Sci U S A19873474623Yes
284825031251.563.5531.8Hydrogels for tissue engineering: scaffold design variables and applications. Jeanie L Drury, David J MooneyBiomaterials200312922147No
284912511251.024.8624.9Searching for genetic determinants in the new millennium. N J RischNature200010866211No
285050041251.0131.132.8Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S VasanStat Med200817569110Yes
285112511251.039.3439.3Tumor delivery of macromolecular drugs based on the EPR effect. Vladimir TorchilinAdv Drug Deliv Rev201120304019No
285250041251.0187.4846.9Predicting effective microRNA target sites in mammalian mRNAs. Vikram Agarwal, George W Bell, Jin-Wu Nam, David P BartelElife201526267216Yes
285312501250.057.6257.6A cognitive approach to panic. D M ClarkBehav Res Ther19863741311Yes
285437491249.787.6929.2Global and societal implications of the diabetes epidemic. P Zimmet, K G Alberti, J ShawNature200111742409No
285512491249.044.5244.5The LMS method for constructing normalized growth standards. T J ColeEur J Clin Nutr19902354692Yes
285612491249.032.6732.7Bacteroides: the good, the bad, and the nitty-gritty. Hannah M WexlerClin Microbiol Rev200717934076No
285724971248.562.6631.3Nanostructures in biodiagnostics. Nathaniel L Rosi, Chad A MirkinChem Rev200515826019No
285824971248.566.7133.4Increasing incidence of thyroid cancer in the United States, 1973-2002. Louise Davies, H Gilbert WelchJAMA200616684987Yes
285924971248.563.9232.0Biology of incretins: GLP-1 and GIP. Laurie L Baggio, Daniel J DruckerGastroenterology200717498508No
286062421248.4232.8946.6DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates. O Folmer, M Black, W Hoeh, R Lutz, R VrijenhoekMol Mar Biol Biotechnol19947881515Yes
286112481248.020.5320.5Antigen receptor tail clue. M RethNature19892927501Yes
286224951247.555.9628.0Cellular processing of platinum anticancer drugs. Dong Wang, Stephen J LippardNat Rev Drug Discov200515789122No
286324951247.564.7632.4Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Barry J Everitt, Trevor W RobbinsNat Neurosci200516251991No
286412471247.052.152.1A cochlear frequency-position function for several species--29 years later. D D GreenwoodJ Acoust Soc Am19902373794Yes
286512471247.041.3841.4Enhancing the quality and credibility of qualitative analysis. M Q PattonHealth Serv Res199910591279No
286612471247.028.9428.9A likelihood approach to estimating phylogeny from discrete morphological character data. P O LewisSyst Biol200112116640Yes
286712471247.038.2838.3Risk and maintenance factors for eating pathology: a meta-analytic review. Eric SticePsychol Bull200212206196No
286812471247.020.5520.6The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. G A RoseBull World Health Organ196213974778Yes
286912471247.032.0432.0Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Earl S FordDiabetes Care200515983333No
287012471247.049.9449.9The variable nature of cognitive control: a dual mechanisms framework. Todd S BraverTrends Cogn Sci201222245618Yes
287124931246.568.5834.3Nitric oxide synthases: roles, tolls, and controls. C Nathan, Q W XieCell19947522969No
287274781246.3247.6541.3The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gøtzsche, Jan P VandenbrouckeJ Clin Epidemiol200818313558Yes
287324921246.049.424.7Community structure in social and biological networks. M Girvan, M E J NewmanProc Natl Acad Sci U S A200212060727No
287424921246.053.3626.7Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Eugenia E Calle, Rudolf KaaksNat Rev Cancer200415286738No
287512461246.058.1758.2When to use the Bonferroni correction. Richard A ArmstrongOphthalmic Physiol Opt201424697967No
287624911245.590.3245.2The stunned myocardium: prolonged, postischemic ventricular dysfunction. E Braunwald, R A KlonerCirculation19826754130No
287712451245.048.4748.5Geriatric Depression Scale. J A YesavagePsychopharmacol Bull19883249773Yes
287824901245.0102.9651.5Reading senseless sentences: brain potentials reflect semantic incongruity. M Kutas, S A HillyardScience19807350657Yes
287912451245.00.00.0Intra-sexual selection in Drosophila. A J BatemanHeredity (Edinb)194818103134Yes
288012451245.038.4338.4Clinical practice. Endometriosis. Linda C GiudiceN Engl J Med201020573927No
288149771244.2281.6370.4Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. L A Papile, J Burstein, R Burstein, H KofflerJ Pediatr1978305471Yes
288224881244.063.3131.7Genetic dissection of complex traits. E S Lander, N J SchorkScience19948091226No
288312441244.027.5427.5Life, death, and the pursuit of apoptosis. E WhiteGenes Dev19968557188No
288412441244.028.3628.4Oxidative stress in neurodegeneration: cause or consequence? Julie K AndersenNat Med200415298006No
288512441244.098.0398.0The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) - China, 2020. The Novel Coronavirus Pneumonia Emergency Response Epidemiology TeamChina CDC Wkly202034594836Yes
288624861243.047.8323.9Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. C W Greider, E H BlackburnCell19853907856Yes
288712431243.022.6222.6Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. P RakicJ Comp Neurol19714101340Yes
288812431243.035.3835.4Varieties of impulsivity. J L EvendenPsychopharmacology (Berl)199910550486No
288912431243.00.00.0A modification of receptor theory. R P StephensonBr J Pharmacol Chemother195613383117Yes
289012431243.030.0730.1Electrochemiluminescence (ECL). Mark M RichterChem Rev200415186186No
289112421242.042.1342.1How is the level of free arachidonic acid controlled in mammalian cells? R F IrvineBiochem J19826810878No
289212421242.045.3645.4Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants. R W BohannonAge Ageing19979143432Yes
289312421242.029.7829.8Plant salt tolerance. J K ZhuTrends Plant Sci200111173290Yes
289412411241.024.6324.6STATs: signal transducers and activators of transcription. J N IhleCell19968608586No
289512411241.035.7935.8Invasive aspergillosis. D W DenningClin Infect Dis19989564455No
289612411241.032.9432.9Akaike's information criterion in generalized estimating equations. W PanBiometrics200111252586Yes
289712411241.00.00.0Sequential tests for the detection of linkage. N E MortonAm J Hum Genet195513258560Yes
289837211240.3182.8961.0Assessing coping strategies: a theoretically based approach. C S Carver, M F Scheier, J K WeintraubJ Pers Soc Psychol19892926629Yes
289912401240.064.6264.6Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. K SatohClin Chim Acta1978719890Yes
290012401240.033.2733.3Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. U MitzdorfPhysiol Rev19853880898No
290124791239.566.0233.0Meeting of minds: the medial frontal cortex and social cognition. David M Amodio, Chris D FrithNat Rev Neurosci200616552413No
2902198321239.5562.1935.1New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). E A Eisenhauer, P Therasse, J Bogaerts, L H Schwartz, D Sargent, R Ford, J Dancey, S Arbuck, S Gwyther, M Mooney, L Rubinstein, L Shankar, L Dodd, R Kaplan, D Lacombe, J VerweijEur J Cancer200919097774No
290399161239.5253.5831.7A method and server for predicting damaging missense mutations. Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R SunyaevNat Methods201020354512Yes
290424781239.076.538.2Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J E Hixson, D T VernierJ Lipid Res19902341813Yes
290512391239.032.3832.4The lipocalin protein family: structure and function. D R FlowerBiochem J19968761444No
290612391239.024.324.3Cytokines induce the development of functionally heterogeneous T helper cell subsets. A O'GarraImmunity19989529145No
290724781239.043.6421.8Stats: transcriptional control and biological impact. David E Levy, J E DarnellNat Rev Mol Cell Biol200212209125No
290812381238.039.0739.1The Danish Register of Causes of Death. Karin Helweg-LarsenScand J Public Health201121775346Yes
290924751237.557.2328.6Peroxisome proliferator-activated receptors: nuclear control of metabolism. B Desvergne, W WahliEndocr Rev199910529898No
291012371237.029.8529.9Measurement of feelings using visual analogue scales. R C AitkenProc R Soc Med19694899510No
291124741237.061.2430.6Molecular mechanisms of action of steroid/thyroid receptor superfamily members. M J Tsai, B W O'MalleyAnnu Rev Biochem19947979245No
291224741237.053.3426.7The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. B N Ames, D T DubinJ Biol Chem196013793161Yes
291312371237.028.9528.9Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. R Balfour SartorNat Clin Pract Gastroenterol Hepatol200616819502No
291412371237.032.2932.3Thermo- and pH-responsive polymers in drug delivery. Dirk SchmaljohannAdv Drug Deliv Rev200617125884No
291537081236.0116.4338.8Qualitative research in health care. Analysing qualitative data. C Pope, S Ziebland, N MaysBMJ200010625273No
291612361236.026.426.4Microglia as a source and target of cytokines. Uwe-Karsten HanischGlia200212379902No
291712361236.037.3637.4Delirium in older persons. Sharon K InouyeN Engl J Med200616540616No
291837071235.7115.538.5Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. B K Matuszewski, M L Constanzer, C M Chavez-EngAnal Chem200312964746Yes
291924711235.564.8832.4A review of central 5-HT receptors and their function. N M Barnes, T SharpNeuropharmacology199910462127No
292024701235.048.2924.1Checkpoints: controls that ensure the order of cell cycle events. L H Hartwell, T A WeinertScience19892683079No
292112351235.037.3837.4Calcium channel modulation by neurotransmitters, enzymes and drugs. H ReuterNature19836131381No
292212351235.054.8154.8The problem with the phrase women and minorities: intersectionality-an important theoretical framework for public health. Lisa BowlegAm J Public Health201222594719Yes
292312351235.074.9775.0Information bias in health research: definition, pitfalls, and adjustment methods. Alaa AlthubaitiJ Multidiscip Healthc201627217764No
292412341234.032.3832.4Low density lipoprotein oxidation and its pathobiological significance. D SteinbergJ Biol Chem19979261091No
292512341234.031.0531.1Functionalized acenes and heteroacenes for organic electronics. John E AnthonyChem Rev200617165682Yes
292624671233.5226.86113.4The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. Hussin A Rothan, Siddappa N ByrareddyJ Autoimmun202032113704No
292724661233.075.3237.7bold: The Barcode of Life Data System (http://www.barcodinglife.org). Sujeevan Ratnasingham, Paul D N HebertMol Ecol Notes200718784790Yes
292812331233.045.3445.3The evolving concept of health literacy. Don NutbeamSoc Sci Med200818952344Yes
292912331233.055.5755.6Salience processing and insular cortical function and dysfunction. Lucina Q UddinNat Rev Neurosci201525406711No
293086271232.4297.5342.5Metagenomic biomarker discovery and explanation. Nicola Segata, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis HuttenhowerGenome Biol201121702898Yes
293149281232.0157.4539.4Validation of a combined comorbidity index. M Charlson, T P Szatrowski, J Peterson, J GoldJ Clin Epidemiol19947722560Yes
293212321232.038.6638.7Antioxidants in human health and disease. B HalliwellAnnu Rev Nutr19968839918No
293312311231.049.4749.5Bone "mass" and the "mechanostat": a proposal. H M FrostAnat Rec19873688455Yes
293412311231.043.5243.5Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. M A LempCLAO J19958565190No
293512311231.030.1830.2Automatic quantitation of localized in vivo 1H spectra with LCModel. S W ProvencherNMR Biomed200111410943Yes
293612311231.027.7527.8Production of recombinant protein therapeutics in cultivated mammalian cells. Florian M WurmNat Biotechnol200415529164No
293761531230.6192.4638.5Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. J S Beckman, T W Beckman, J Chen, P A Marshall, B A FreemanProc Natl Acad Sci U S A19902154753Yes
293812301230.044.1144.1Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. R M PostAm J Psychiatry19921353322No
293924601230.068.334.1Ageing and Parkinson's disease: substantia nigra regional selectivity. J M Fearnley, A J LeesBrain19911933245Yes
294012301230.037.9337.9Sensorimotor integration in human postural control. R J PeterkaJ Neurophysiol200212205132Yes
294112291229.021.8421.8Mutation selection and the natural history of cancer. J CairnsNature19751143315Yes
294212291229.022.6622.7Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Ricky W JohnstoneNat Rev Drug Discov200212120280No
294324571228.539.4619.7A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. D Tautz, C PfeifleChromosoma19892476281Yes
294412281228.045.0745.1The P300 wave of the human event-related potential. T W PictonJ Clin Neurophysiol19921464675No
294512281228.027.2727.3Brain tumors. L M DeAngelisN Engl J Med200111150363No
294624561228.072.6536.3Inflammatory mechanisms in obesity. Margaret F Gregor, Gökhan S HotamisligilAnnu Rev Immunol201121219177No
294724551227.558.8329.4Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects. R P Rao, D H BallardNat Neurosci199910195184Yes
294824541227.065.732.9Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. M A Pfeffer, E BraunwaldCirculation19902138525No
294924541227.048.7324.4Of mice and not men: differences between mouse and human immunology. Javier Mestas, Christopher C W HughesJ Immunol200414978070No
295012271227.031.2831.3The complex role of estrogens in inflammation. Rainer H StraubEndocr Rev200717640948No
295173601226.7205.3134.2Genome engineering using the CRISPR-Cas9 system. F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng ZhangNat Protoc201324157548Yes
295261311226.2247.0649.4Integrating single-cell transcriptomic data across different conditions, technologies, and species. Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi, Rahul SatijaNat Biotechnol201829608179Yes
295312261226.055.2655.3Continuous improvement as an ideal in health care. D M BerwickN Engl J Med19892909878Yes
295412261226.032.0332.0Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. P O SeglenExp Cell Res19734358115Yes
295512261226.032.9833.0The emotional dog and its rational tail: a social intuitionist approach to moral judgment. J HaidtPsychol Rev200111699120Yes
295612261226.024.4824.5Basement membranes: structure, assembly and role in tumour angiogenesis. Raghu KalluriNat Rev Cancer200312778132No
295712261226.025.1725.2Fibrotic disease and the T(H)1/T(H)2 paradigm. Thomas A WynnNat Rev Immunol200415286725No
295824511225.554.2227.1Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. G K McMaster, G G CarmichaelProc Natl Acad Sci U S A197773185Yes
295912251225.026.3326.3Nuclear factor-kappaB: the enemy within. Bharat B AggarwalCancer Cell200415380510No
296012241224.033.7833.8Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. F HeftiJ Neurosci19863746405Yes
296112241224.030.9430.9Neural systems for recognizing emotion. Ralph AdolphsCurr Opin Neurobiol200212015233No
296224461223.063.131.6The ubiquitin code. David Komander, Michael RapeAnnu Rev Biochem201222524316No
296324461223.094.4747.2Kraken: ultrafast metagenomic sequence classification using exact alignments. Derrick E Wood, Steven L SalzbergGenome Biol201424580807Yes
296412221222.025.7125.7Antigen-presenting function of the macrophage. E R UnanueAnnu Rev Immunol19846242349No
296512221222.022.222.2Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. H E RuleyNature19836308473Yes
296612221222.022.0722.1Kinesin and dynein superfamily proteins and the mechanism of organelle transport. N HirokawaScience19989438838No
296712221222.015.0715.1Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. J M Van RossumArch Int Pharmacodyn Ther196313996119Yes
296812221222.034.8734.9High prevalence of vitamin D inadequacy and implications for health. Michael F HolickMayo Clin Proc200616529140No
296912221222.030.830.8Polymer conjugates as anticancer nanomedicines. Ruth DuncanNat Rev Cancer200616900224No
297012221222.033.8333.8Water as an active constituent in cell biology. Philip BallChem Rev200818095715No
297112211221.020.1720.2Mitotic kinases as regulators of cell division and its checkpoints. E A NiggNat Rev Mol Cell Biol200111413462No
297212211221.035.135.1The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. R G PertweeBr J Pharmacol200817828291No
297312201220.028.6928.7Growth factors and cancer. S A AaronsonScience19911659742No
297412201220.025.2725.3MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. R N GermainCell19948293464No
297512201220.033.4533.5Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Antoine BecharaNat Neurosci200516251988No
297648801220.0134.8733.7AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang GuanNat Cell Biol201121258367Yes
297724391219.574.8737.4A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. A Ennaceur, J DelacourBehav Brain Res19883228475Yes
297812191219.016.416.4The concept of immunological surveillance. F M BurnetProg Exp Tumor Res19704921480No
297912181218.026.5426.5Heterotrimeric G proteins: organizers of transmembrane signals. E J NeerCell19957834744No
298012181218.030.430.4Endothelial-leukocyte adhesion molecules. M P BevilacquaAnnu Rev Immunol19938476577No
298112181218.025.8925.9Dendritic cells: unique leukocyte populations which control the primary immune response. D N HartBlood19979345009No
298212181218.025.2525.2Caspase structure, proteolytic substrates, and function during apoptotic cell death. D W NicholsonCell Death Differ199910578171No
298324361218.057.528.8Principles of bioactive lipid signalling: lessons from sphingolipids. Yusuf A Hannun, Lina M ObeidNat Rev Mol Cell Biol200818216770No
298436511217.076.5525.5Computer visualization of three-dimensional image data using IMOD. J R Kremer, D N Mastronarde, J R McIntoshJ Struct Biol19968742726Yes
298512171217.034.4234.4Electrochemical glucose biosensors. Joseph WangChem Rev200818154363No
298612171217.046.9947.0A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading. Cathy J PriceNeuroimage201222584224No
298724331216.526.2213.1The Aggregation Of Blood Platelets. G V Born, M J CrossJ Physiol196314056485Yes
298848651216.22040.64510.2Cancer statistics, 2023. Rebecca L Siegel, Kimberly D Miller, Nikita Sandeep Wagle, Ahmedin JemalCA Cancer J Clin202336633525Yes
298912161216.045.4745.5A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. S T TiffanyPsychol Rev19902186423No
299012161216.044.5844.6Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. S H SafeCrit Rev Toxicol19948037844No
299124321216.064.1132.1A neurotrophic model for stress-related mood disorders. Ronald S Duman, Lisa M MonteggiaBiol Psychiatry200616631126No
299236471215.761.2820.4A system for stable expression of short interfering RNAs in mammalian cells. Thijn R Brummelkamp, René Bernards, Reuven AgamiScience200211910072Yes
299336461215.3112.3337.4Evaluating the public health impact of health promotion interventions: the RE-AIM framework. R E Glasgow, T M Vogt, S M BolesAm J Public Health199910474547No
299448611215.2112.9428.2Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. G L Wang, B H Jiang, E A Rue, G L SemenzaProc Natl Acad Sci U S A19957539918Yes
299512151215.042.3442.3Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. A J AlpertJ Chromatogr19902324207Yes
299612151215.058.9859.0ROC methodology in radiologic imaging. C E MetzInvest Radiol19863095258No
299712151215.020.3720.4Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J O HolloszyJ Biol Chem19674290225Yes
299824301215.062.331.1Humans integrate visual and haptic information in a statistically optimal fashion. Marc O Ernst, Martin S BanksNature200211807554Yes
299924301215.047.8423.9Molecular chaperones in the cytosol: from nascent chain to folded protein. F Ulrich Hartl, Manajit Hayer-HartlScience200211884745No
300012151215.025.0325.0Platelets in atherothrombosis. Zaverio M RuggeriNat Med200212411949No
300112151215.023.3823.4Lipid rafts: elusive or illusive? Sean MunroCell200314622593No
300212151215.031.7831.8Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Paul WillnerNeuropsychobiology200516037678No
300312151215.024.1824.2Protein tyrosine phosphatases: from genes, to function, to disease. Nicholas K TonksNat Rev Mol Cell Biol200617057753No
300412151215.037.7837.8Socioeconomic status and obesity. Lindsay McLarenEpidemiol Rev200717478442No
300512151215.051.1551.1The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults. L S RadloffJ Youth Adolesc199124265004Yes
300612151215.058.6358.6The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease. Costantino IadecolaNeuron201728957666No
300724291214.578.5139.3Atomic structure and chemistry of human serum albumin. X M He, D C CarterNature19921630489Yes
300824291214.567.0333.5New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. Jonathan B Baell, Georgina A HollowayJ Med Chem201020131845Yes
300912121212.024.324.3Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. Sean B CarrollCell200818614008Yes
301060561211.2295.4759.1Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W StittJ Rheumatol19883068365Yes
301112111211.029.3429.3Bcl-2 initiates a new category of oncogenes: regulators of cell death. S J KorsmeyerBlood19921498330No
301224221211.036.5618.3High resolution acrylamide gel electrophoresis of histones. S Panyim, R ChalkleyArch Biochem Biophys19695778650Yes
301312111211.023.123.1IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Yong-Jun LiuAnnu Rev Immunol200515771572No
301472631210.5135.0222.5Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T TuschlNature200111373684Yes
301524211210.552.6126.3Toll-like receptors in innate immunity. Kiyoshi Takeda, Shizuo AkiraInt Immunol200515585605No
3016108931210.3278.130.9MolProbity: all-atom structure validation for macromolecular crystallography. Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C RichardsonActa Crystallogr D Biol Crystallogr201020057044Yes
301712101210.061.7961.8Rating scales to assess depression in school-aged children. M KovacsActa Paedopsychiatr19817025571Yes
301812101210.025.0225.0Morphogenetic roles of classic cadherins. M TakeichiCurr Opin Cell Biol19958573335No
301912101210.044.7844.8The biogenesis and emerging roles of circular RNAs. Ling-Ling ChenNat Rev Mol Cell Biol201626908011Yes
302024191209.568.8434.4Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. Xiaobo Chen, Samuel S MaoChem Rev200717590053Yes
302148371209.2150.7437.7Epidemiology and causes of preterm birth. Robert L Goldenberg, Jennifer F Culhane, Jay D Iams, Roberto RomeroLancet200818177778No
302224181209.097.1348.6The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. R Näätänen, T PictonPsychophysiology19873615753Yes
302312091209.026.2826.3An overview of epithelio-mesenchymal transformation. E D HayActa Anat (Basel)19958714286No
302412091209.033.1133.1The stress response to trauma and surgery. J P DesboroughBr J Anaesth200010927999No
302548331208.2127.9532.0Organometal halide perovskites as visible-light sensitizers for photovoltaic cells. Akihiro Kojima, Kenjiro Teshima, Yasuo Shirai, Tsutomu MiyasakaJ Am Chem Soc200919366264Yes
302612081208.026.7526.8Translating cell biology into therapeutic advances in Alzheimer's disease. D J SelkoeNature199910392577No
302748321208.0131.332.8Measurement of the elastic properties and intrinsic strength of monolayer graphene. Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James HoneScience200818635798Yes
302812071207.038.5738.6Linkage map of Escherichia coli K-12, edition 7. B J BachmannMicrobiol Rev19836348505No
302912071207.066.6366.6Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV. Douglas A DrossmanGastroenterology201627144617Yes
303036201206.7102.0234.0Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. H King, R E Aubert, W H HermanDiabetes Care19989727886Yes
303124131206.559.7929.9Rising incidence of hepatocellular carcinoma in the United States. H B El-Serag, A C MasonN Engl J Med199910072408Yes
303212061206.052.6152.6Campylobacter enteritis: a "new" disease. M B SkirrowBr Med J1977871765Yes
303324121206.050.0625.0Sequence logos: a new way to display consensus sequences. T D Schneider, R M StephensNucleic Acids Res19902172928Yes
303424121206.046.1723.1Dynamic instability of microtubule growth. T Mitchison, M KirschnerNature19846504138Yes
303512061206.048.3848.4Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. E H BeacheyJ Infect Dis19817014727No
303624121206.059.1729.6Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. M E Feder, G E HofmannAnnu Rev Physiol199910099689No
303712061206.031.1931.2Q-ball imaging. David S TuchMagn Reson Med200415562495Yes
303812061206.023.823.8Up on the tightrope: natural killer cell activation and inhibition. Lewis L LanierNat Immunol200818425106No
303912061206.033.933.9Atomic layer deposition: an overview. Steven M GeorgeChem Rev201019947596Yes
304012061206.029.7729.8Molecular genetics of colorectal cancer. Eric R FearonAnnu Rev Pathol201121090969No
304112061206.058.6358.6The new statistics: why and how. Geoff CummingPsychol Sci201424220629Yes
304212051205.041.2641.3Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases. K TamuraMol Biol Evol19921630306Yes
304312051205.040.7140.7The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. N M KaplanArch Intern Med19892662932No
304436151205.0217.4672.5Production, use, and fate of all plastics ever made. Roland Geyer, Jenna R Jambeck, Kara Lavender LawSci Adv201728776036Yes
304536131204.372.2524.1Large-scale analysis of the yeast proteome by multidimensional protein identification technology. M P Washburn, D Wolters, J R YatesNat Biotechnol200111231557Yes
304624081204.071.4435.7Recent advances in the phencyclidine model of schizophrenia. D C Javitt, S R ZukinAm J Psychiatry19911654746No
304712041204.034.3934.4MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Amy E PasquinelliNat Rev Genet201222411466No
304812041204.046.9947.0The biology and function of exosomes in cancer. Raghu KalluriJ Clin Invest201627035812No
304948151203.8135.7433.9Biological identifications through DNA barcodes. Paul D N Hebert, Alina Cywinska, Shelley L Ball, Jeremy R deWaardProc Biol Sci200312614582Yes
305024071203.563.1431.6Imaging cognition II: An empirical review of 275 PET and fMRI studies. R Cabeza, L NybergJ Cogn Neurosci200010769304No
305112031203.034.9434.9A human model of gastric carcinogenesis. P CorreaCancer Res19883288329No
305212031203.028.0828.1Intracellular protein topogenesis. G BlobelProc Natl Acad Sci U S A19806929499Yes
305324061203.064.3332.2Leukocyte-endothelial adhesion molecules. T M Carlos, J M HarlanBlood19947522621No
305412031203.037.2637.3Peritonectomy procedures. P H SugarbakerAnn Surg19957826158Yes
305512031203.023.4823.5A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. Xuemei ChenScience200412893888Yes
305612021202.033.1333.1Normalization of cell responses in cat striate cortex. D J HeegerVis Neurosci19921504027Yes
305712021202.041.4241.4Assay of intestinal disaccharidases. A DahlqvistAnal Biochem19685636962Yes
305812021202.019.6619.7Studies on phosphatidylcholine vesicles. Formation and physical characteristics. C HuangBiochemistry19695777332Yes
305912021202.028.6328.6Metabolism and functions of glutathione in brain. R DringenProg Neurobiol200010880854No
306012021202.025.9926.0Simple model of spiking neurons. E M IzhikevichIEEE Trans Neural Netw200318244602Yes
3061120151201.5433.0543.3The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gøtzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David MoherBMJ200919622552No
306236041201.3264.5488.2Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles. Aldenor G Santos, Gisele O da Rocha, Jailson B de AndradeSci Rep201930626917Yes
306312011201.035.0735.1Analyzing the mosaic structure of genes. J M SmithJ Mol Evol19921556748No
306412011201.034.1134.1What is synergy? M C BerenbaumPharmacol Rev19892692037No
306512011201.033.3633.4Papillary and follicular thyroid carcinoma. M J SchlumbergerN Engl J Med19989445411No
306612011201.025.6125.6The finer things in X-ray diffraction data collection. J W PflugrathActa Crystallogr D Biol Crystallogr199910531521Yes
306736001200.086.7628.9Functional diversity of helper T lymphocytes. A K Abbas, K M Murphy, A SherNature19968893001No
306812001200.032.1532.1Core affect and the psychological construction of emotion. James A RussellPsychol Rev200312529060No
306912001200.028.5928.6Targeting DNA topoisomerase II in cancer chemotherapy. John L NitissNat Rev Cancer200919377506No
307047991199.8132.0433.0Toxic potential of materials at the nanolevel. Andre Nel, Tian Xia, Lutz Mädler, Ning LiScience200616456071No
307123981199.053.0826.5Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. T Hunter, B M SeftonProc Natl Acad Sci U S A19806246487Yes
307211991199.030.2930.3Disorders of iron metabolism. N C AndrewsN Engl J Med199910607817No
307323981199.049.0224.5NF-kappaB: linking inflammation and immunity to cancer development and progression. Michael Karin, Florian R GretenNat Rev Immunol200516175180No
307411991199.00.00.0Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. P B MedawarBr J Exp Pathol194818865105Yes
307511981198.035.1535.1Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. W SieghartPharmacol Rev19957568326No
307611981198.032.9132.9Diversity of group types, regulation, and function of phospholipase A2. E A DennisJ Biol Chem19948175726No
307711981198.029.0329.0The neuropathology of schizophrenia. A critical review of the data and their interpretation. P J HarrisonBrain199910219775No
307811981198.026.9927.0Mitochondrial transport of cations: channels, exchangers, and permeability transition. P BernardiPhysiol Rev199910508231No
307923961198.032.4516.2Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. R R Guillard, J H RytherCan J Microbiol196213902807Yes
308011981198.058.4458.4Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review. Dariush MozaffarianCirculation201626746178No
308135921197.373.1624.4Toll-like receptors: critical proteins linking innate and acquired immunity. S Akira, K Takeda, T KaishoNat Immunol200111477402No
308235921197.389.5829.9Use and abuse of HOMA modeling. Tara M Wallace, Jonathan C Levy, David R MatthewsDiabetes Care200415161807No
308311971197.029.8329.8Hereditary cancer, oncogenes, and antioncogenes. A G KnudsonCancer Res19852983882Yes
308423941197.061.7530.9Statistical tests of neutrality of mutations. Y X Fu, W H LiGenetics19938454210Yes
308511971197.020.8220.8Stem cells: units of development, units of regeneration, and units in evolution. I L WeissmanCell200010647940No
308623931196.596.5948.3Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococcus species. R Vilgalys, M HesterJ Bacteriol19902376561Yes
308723931196.549.6124.8Atherosclerosis. the road ahead. C K Glass, J L WitztumCell200111239408No
308859811196.2200.9540.2Posttraumatic stress disorder in the National Comorbidity Survey. R C Kessler, A Sonnega, E Bromet, M Hughes, C B NelsonArch Gen Psychiatry19957492257Yes
308923921196.085.2142.6Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. A Fabiato, F FabiatoJ Physiol (Paris)1979533865Yes
309011961196.038.1138.1The pathogenesis of sepsis. R C BoneAnn Intern Med19911872494No
309111961196.028.0428.0Matrix proteoglycans: from molecular design to cellular function. R V IozzoAnnu Rev Biochem19989759499No
309211961196.035.1335.1The structure of common mental disorders. R F KruegerArch Gen Psychiatry199910530634Yes
309311961196.039.0939.1Starting at the beginning: an introduction to coefficient alpha and internal consistency. David L StreinerJ Pers Assess200312584072Yes
309471751195.8268.1644.7Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Laura J Damschroder, David C Aron, Rosalind E Keith, Susan R Kirsh, Jeffery A Alexander, Julie C LoweryImplement Sci200919664226Yes
309535851195.0166.1555.4Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. F Guillemin, C Bombardier, D BeatonJ Clin Epidemiol19938263569No
309611951195.030.2530.2Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. G BodenDiabetes19978971073No
309711951195.040.2340.2Volumetric modulated arc therapy: IMRT in a single gantry arc. Karl OttoMed Phys200818293586Yes
309823901195.084.8942.4Severe sepsis and septic shock. Derek C Angus, Tom van der PollN Engl J Med201323984731No
309911941194.048.9649.0Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). S SafeCrit Rev Toxicol19902124811No
310011941194.028.4528.4Rapid and sensitive sequence comparison with FASTP and FASTA. W R PearsonMethods Enzymol19902156132Yes
310111941194.028.4628.5A tension-based theory of morphogenesis and compact wiring in the central nervous system. D C Van EssenNature19979002514Yes
310235821194.083.8828.0Prediction of total genetic value using genome-wide dense marker maps. T H Meuwissen, B J Hayes, M E GoddardGenetics200111290733Yes
310311941194.026.0526.1How neutrophils kill microbes. Anthony W SegalAnnu Rev Immunol200515771570No
310411941194.030.2930.3Physiology and pathophysiology of purinergic neurotransmission. Geoffrey BurnstockPhysiol Rev200717429044No
310523881194.071.3335.7Plasmonics for improved photovoltaic devices. Harry A Atwater, Albert PolmanNat Mater201020168344Yes
310623881194.096.6248.3Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. Ian Janssen, Allana G LeblancInt J Behav Nutr Phys Act201020459784Yes
310711941194.044.3944.4Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. George S BloomJAMA Neurol201424493463No
310823871193.5213.07106.5Radiological demarcation of cemented sockets in total hip replacement. J G DeLee, J CharnleyClin Orthop Relat Res1976991504Yes
310923871193.565.8432.9Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. R G Phillips, J E LeDouxBehav Neurosci19921590953Yes
311011931193.036.0736.1The mysteries of lipoprotein(a). G UtermannScience19892530631No
311111931193.039.1139.1Checklists for improving rigour in qualitative research: a case of the tail wagging the dog? R S BarbourBMJ200111337448No
311235761192.090.7430.2Methods in mammalian autophagy research. Noboru Mizushima, Tamotsu Yoshimori, Beth LevineCell201020144757Yes
3113107211191.2273.7730.4Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Cole Trapnell, Brian A Williams, Geo Pertea, Ali Mortazavi, Gordon Kwan, Marijke J van Baren, Steven L Salzberg, Barbara J Wold, Lior PachterNat Biotechnol201020436464Yes
311411911191.036.7936.8Biosynthesis and metabolism of endothelium-derived nitric oxide. L J IgnarroAnnu Rev Pharmacol Toxicol19902188578No
311511911191.074.2374.2Impingement lesions. C S NeerClin Orthop Relat Res19836825348Yes
311611911191.00.00.0A production of amino acids under possible primitive earth conditions. S L MillerScience195313056598Yes
311711911191.027.827.8Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. Christopher Paul WildCancer Epidemiol Biomarkers Prev200516103423No
311847621190.5137.5334.4Place navigation impaired in rats with hippocampal lesions. R G Morris, P Garrud, J N Rawlins, J O'KeefeNature19827088155Yes
311923811190.569.2334.6Natural products as sources of new drugs over the last 25 years. David J Newman, Gordon M CraggJ Nat Prod200717309302No
312059521190.4141.0228.2Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L CoffmanJ Immunol19862419430Yes
312135701190.085.8228.6Astrocyte-endothelial interactions at the blood-brain barrier. N Joan Abbott, Lars Rönnbäck, Elisabeth HanssonNat Rev Neurosci200616371949No
312211891189.021.3721.4Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. D HanahanNature19852986015Yes
312311891189.025.5325.5The myofibroblast in wound healing and fibrocontractive diseases. G GabbianiJ Pathol200312845617No
312411891189.021.9121.9Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. G D WinterNature196214007593Yes
312511891189.056.2656.3The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. W G DuncombeClin Chim Acta196414122498Yes
312623771188.548.5524.3The mammalian unfolded protein response. Martin Schröder, Randal J KaufmanAnnu Rev Biochem200515952902No
3127106951188.3353.8639.3A novel potent vasoconstrictor peptide produced by vascular endothelial cells. M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T MasakiNature19882451132Yes
312835651188.3150.0250.0Measurement of health status. Ascertaining the minimal clinically important difference. R Jaeschke, J Singer, G H GuyattControl Clin Trials19892691207Yes
312911881188.023.4723.5Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. Harold F DvorakJ Clin Oncol200212409337No
313011881188.024.924.9The advantages and disadvantages of being polyploid. Luca ComaiNat Rev Genet200516304599No
313123761188.066.5933.3Heterogeneous photocatalyst materials for water splitting. Akihiko Kudo, Yugo MisekiChem Soc Rev200919088977Yes
313223741187.0112.256.1Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. J D Peuler, G A JohnsonLife Sci1977904439Yes
313335611187.0110.7436.9The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. G Blessed, B E Tomlinson, M RothBr J Psychiatry19685662937Yes
313411871187.039.4339.4Mediators and mechanisms of change in psychotherapy research. Alan E KazdinAnnu Rev Clin Psychol200717716046No
313523731186.574.2237.1Antiseptics and disinfectants: activity, action, and resistance. G McDonnell, A D RussellClin Microbiol Rev19999880479No
3136118631186.3460.5346.1MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space. Fredrik Ronquist, Maxim Teslenko, Paul van der Mark, Daniel L Ayres, Aaron Darling, Sebastian Höhna, Bret Larget, Liang Liu, Marc A Suchard, John P HuelsenbeckSyst Biol201222357727Yes
313711861186.052.4252.4Presynaptic regulation of the release of catecholamines. S Z LangerPharmacol Rev19806267618Yes
313811861186.045.3345.3Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. H V GelboinPhysiol Rev19807001511No
313911861186.019.1719.2Themes and variations on ubiquitylation. A M WeissmanNat Rev Mol Cell Biol200111265246No
314023711185.5102.651.3Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. P R Hunter, M A GastonJ Clin Microbiol19883069867Yes
314123711185.595.3247.7Rapid procedure for detection and isolation of large and small plasmids. C I Kado, S T LiuJ Bacteriol19817009583Yes
314223711185.547.9924.0Learning the parts of objects by non-negative matrix factorization. D D Lee, H S SeungNature199910548103Yes
314323701185.088.0344.0Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. H Esterbauer, K H CheesemanMethods Enzymol19902233308Yes
314411851185.042.7842.8The case for motivated reasoning. Z KundaPsychol Bull19902270237No
314523701185.076.6238.3Physiological parameters in laboratory animals and humans. B Davies, T MorrisPharm Res19938378254No
314611851185.030.6530.6The neurobiology of stress: from serendipity to clinical relevance. B S McEwenBrain Res200011119695No
314711851185.031.7731.8Production and scavenging of reactive oxygen species in chloroplasts and their functions. Kozi AsadaPlant Physiol200616760493Yes
314823701185.054.7327.4Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Julie A Law, Steven E JacobsenNat Rev Genet201020142834No
314911851185.045.1445.1Myeloid-Derived Suppressor Cells. Dmitry I GabrilovichCancer Immunol Res201728052991No
315011851185.074.674.6Non-alcoholic fatty liver disease - A global public health perspective. Zobair M YounossiJ Hepatol201930414863No
315123691184.553.0326.5Adaptive protein evolution at the Adh locus in Drosophila. J H McDonald, M KreitmanNature19911904993Yes
3152165821184.4353.7925.3Crystallography & NMR system: A new software suite for macromolecular structure determination. A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L WarrenActa Crystallogr D Biol Crystallogr19989757107Yes
315335531184.372.0424.0Cellular survival: a play in three Akts. S R Datta, A Brunet, M E GreenbergGenes Dev199910579998No
315411841184.066.0966.1Nontuberculous mycobacteria and associated diseases. E WolinskyAm Rev Respir Dis1979369415No
315511841184.026.6926.7The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. S J CollinsBlood19873311197No
315611841184.036.0336.0A practical solution to the pervasive problems of p values. Eric-Jan WagenmakersPsychon Bull Rev200718087943Yes
315723681184.052.2126.1Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Jing Yang, Robert A WeinbergDev Cell200818539112No
315823671183.543.6321.8Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. C Li, W H WongProc Natl Acad Sci U S A200111134512Yes
315911831183.038.138.1Agents that increase the permeability of the outer membrane. M VaaraMicrobiol Rev19921406489No
316011831183.00.00.0Voluntary strength and fatigue. P A MertonJ Physiol195413152698Yes
316111831183.024.424.4Microsatellites: simple sequences with complex evolution. Hans EllegrenNat Rev Genet200415153996No
316211831183.042.2642.3Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls? Fay B HorakAge Ageing200616926210No
316323661183.094.3247.2Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Ulrich M Zanger, Matthias SchwabPharmacol Ther201323333322No
3164118281182.8296.9129.7Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. M Dominici, K Le Blanc, I Mueller, I Slaper-Cortenbach, Fc Marini, Ds Krause, Rj Deans, A Keating, Dj Prockop, Em HorwitzCytotherapy200616923606Yes
316523651182.576.838.4Quantitative determination of serum triglycerides by the use of enzymes. G Bucolo, H DavidClin Chem19734703655Yes
316611821182.040.7440.7An approach for the treatment of penile carcinoma. R M CabanasCancer1977837331Yes
316711821182.036.2336.2The somatic marker hypothesis and the possible functions of the prefrontal cortex. A R DamasioPhilos Trans R Soc Lond B Biol Sci19968941953No
316859091181.8167.0333.4Quantitative assessment of tactile allodynia in the rat paw. S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L YakshJ Neurosci Methods19947990513Yes
316911811181.013.5113.5Central dogma of molecular biology. F CrickNature19704913914No
317011811181.026.7826.8Hybridization of denatured RNA transferred or dotted nitrocellulose paper. P S ThomasMethods Enzymol19836194404Yes
317111811181.035.7335.7Platelet-rich plasma: evidence to support its use. Robert E MarxJ Oral Maxillofac Surg200415085519No
317235431181.0115.8738.6Hepatocellular carcinoma. Alejandro Forner, Josep M Llovet, Jordi BruixLancet201222353262No
317311811181.079.0479.0Epidemiology of Prostate Cancer. Prashanth RawlaWorld J Oncol201931068988No
317459041180.8192.0538.4Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L WitztumN Engl J Med19892648148No
317535421180.7120.9240.3The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting. C Kirschbaum, K M Pirke, D H HellhammerNeuropsychobiology19938255414Yes
317682621180.3162.5323.2Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P SpeedBiostatistics200312925520Yes
317723601180.077.2338.6Efficacy of the Theory of Planned Behaviour: a meta-analytic review. C J Armitage, M ConnerBr J Soc Psychol200111795063Yes
317847191179.8106.1326.5Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. J E Walker, M Saraste, M J Runswick, N J GayEMBO J19826329717Yes
317923591179.5112.6556.3Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. S F Dworkin, L LeRescheJ Craniomandib Disord19921298767No
318023591179.563.3231.7A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions. Yan Zhao, Donald G TruhlarJ Chem Phys200617129083Yes
318123591179.5243.71121.9Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. David J Newman, Gordon M CraggJ Nat Prod202032162523No
318223581179.042.2421.1Hedgehog signaling in animal development: paradigms and principles. P W Ingham, A P McMahonGenes Dev200111731473No
318311791179.026.7626.8Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. William C AirdCirc Res200717272818No
318411791179.049.8149.8How neuroinflammation contributes to neurodegeneration. Richard M RansohoffScience201627540165No
318535371179.0180.5560.2Hepatocellular carcinoma. Alejandro Forner, María Reig, Jordi BruixLancet201829307467No
318623571178.561.130.6Verification of protein structures: patterns of nonbonded atomic interactions. C Colovos, T O YeatesProtein Sci19938401235Yes
318723571178.548.4524.2Toll-like receptors in the induction of the innate immune response. A Aderem, R J UlevitchNature200010963608No
318823561178.066.9133.5The low-density lipoprotein pathway and its relation to atherosclerosis. J L Goldstein, M S BrownAnnu Rev Biochem1977197883No
318923561178.075.437.7Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. A Warshel, M LevittJ Mol Biol1976985660Yes
319011781178.00.00.0The perceptron: a probabilistic model for information storage and organization in the brain. F RosenblattPsychol Rev195813602029Yes
319111781178.022.8722.9Telomeres and human disease: ageing, cancer and beyond. Maria A BlascoNat Rev Genet200516136653No
319211781178.028.2228.2Correlates of protection induced by vaccination. Stanley A PlotkinClin Vaccine Immunol201020463105No
319311781178.00.00.0Histological demonstration of mucin after periodic acid. J F A McMANUSNature194620995486Yes
319411781178.058.9258.9Patient reported outcome measures could help transform healthcare. Nick BlackBMJ201323358487Yes
319523541177.080.7240.4The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. G P Chrousos, P W GoldJAMA19921538563No
319611771177.038.9338.9Interleukin-1 and the pathogenesis of the acute-phase response. C A DinarelloN Engl J Med19846208485No
319711771177.0107.84107.8The analysis of errors in orthodontic measurements. W J HoustonAm J Orthod19836573846Yes
319811771177.032.4132.4The induction of pain: an integrative review. M J MillanProg Neurobiol19999987804No
319947081177.090.2622.6Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. L Alexopoulou, A C Holt, R Medzhitov, R A FlavellNature200111607032Yes
320011771177.00.00.0A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. M G BuonocoreJ Dent Res195513271655Yes
320123541177.050.5225.3Blinded by the Light: The Growing Complexity of p53. Karen H Vousden, Carol PrivesCell200919410540No
320211771177.047.7547.8The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. Natalie A de MortonAust J Physiother200919463084Yes
320335311177.0104.6834.9SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building. Manolo Gouy, Stéphane Guindon, Olivier GascuelMol Biol Evol201019854763Yes
320423531176.591.7745.9A simple method to assess exercise behavior in the community. G Godin, R J ShephardCan J Appl Sport Sci19854053261Yes
320523531176.570.9735.5Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. S Geman, D GemanIEEE Trans Pattern Anal Mach Intell198422499653Yes
320623521176.072.9336.5The reward circuit: linking primate anatomy and human imaging. Suzanne N Haber, Brian KnutsonNeuropsychopharmacology201019812543No
320711761176.049.4349.4The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review. Erik G WillcuttNeurotherapeutics201222976615No
320835261175.3144.3348.1Principles of nanoparticle design for overcoming biological barriers to drug delivery. Elvin Blanco, Haifa Shen, Mauro FerrariNat Biotechnol201526348965Yes
320935251175.090.2530.1Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. C R Woese, O Kandler, M L WheelisProc Natl Acad Sci U S A19902112744Yes
321011751175.033.3733.4On the law of effect. R J HerrnsteinJ Exp Anal Behav197016811440Yes
321123481174.045.9923.0Multiple nuclear factors interact with the immunoglobulin enhancer sequences. R Sen, D BaltimoreCell19863091258Yes
321223481174.053.9127.0Regulation of wound healing by growth factors and cytokines. Sabine Werner, Richard GrosePhysiol Rev200312843410No
321311741174.028.0828.1Context and behavioral processes in extinction. Mark E BoutonLearn Mem200415466298No
321435211173.792.3630.8Matrix metalloproteinases: regulators of the tumor microenvironment. Kai Kessenbrock, Vicki Plaks, Zena WerbCell201020371345No
321511731173.030.8430.8Pathogenesis of dengue: challenges to molecular biology. S B HalsteadScience19883277268No
321611731173.035.9536.0Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. M E BoutonPsychol Bull19938346330No
321711731173.024.0824.1Apoptosis in neurodegenerative disorders. M P MattsonNat Rev Mol Cell Biol200011253364No
321823451172.568.8434.4Type 2 diabetes as an inflammatory disease. Marc Y Donath, Steven E ShoelsonNat Rev Immunol201121233852No
321911721172.024.7324.7Epstein-Barr virus infection. J I CohenN Engl J Med200010944566No
322023441172.053.9627.0Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Josep M Llovet, Jordi BruixHepatology200312540794No
322111721172.030.7330.7A theory of magnitude: common cortical metrics of time, space and quantity. Vincent WalshTrends Cogn Sci200314585444Yes
322235141171.370.6123.5Predicting coiled coils from protein sequences. A Lupas, M Van Dyke, J StockScience19912031185Yes
322358561171.2109.2321.8The protein kinase complement of the human genome. G Manning, D B Whyte, R Martinez, T Hunter, S SudarsanamScience200212471243No
322423421171.070.0135.0Mitochondrial fission, fusion, and stress. Richard J Youle, Alexander M van der BliekScience201222936770No
322523411170.569.6534.8Multiple significance tests: the Bonferroni method. J M Bland, D G AltmanBMJ19957833759Yes
322623411170.548.6624.3Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Nahum Sonenberg, Alan G HinnebuschCell200919239892No
322711701170.035.6835.7MOPAC: a semiempirical molecular orbital program. J J StewartJ Comput Aided Mol Des19902197373No
322811701170.034.134.1Determinants of tumor blood flow: a review. R K JainCancer Res19883282647No
322911701170.027.1427.1The epidemiologic transition. A theory of the epidemiology of population change. A R OmranMilbank Mem Fund Q19715155251Yes
323011701170.025.1425.1Serine protease mechanism and specificity. Lizbeth HedstromChem Rev200212475199No
323111701170.055.0455.0Preliminary Trial Of Carisoprodol In Multiple Sclerosis. B AshworthPractitioner196414143329Yes
323223391169.574.1637.1Solubilization of membranes by detergents. A Helenius, K SimonsBiochim Biophys Acta19751091302No
323323391169.536.718.4Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. J D McGhee, P H von HippelJ Mol Biol19744416620Yes
323470161169.3239.5839.9The occurrence of sleep-disordered breathing among middle-aged adults. T Young, M Palta, J Dempsey, J Skatrud, S Weber, S BadrN Engl J Med19938464434Yes
323511691169.030.6230.6Epidemiology of women and depression. Ronald C KesslerJ Affect Disord200312646294Yes
323635071169.091.6530.6Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Dunyaporn Trachootham, Jerome Alexandre, Peng HuangNat Rev Drug Discov200919478820No
323735061168.776.9925.7Hepatocellular carcinoma. Josep M Llovet, Andrew Burroughs, Jordi BruixLancet200314667750No
323811681168.033.2833.36-Hydroxy-dopamine induced degeneration of central monoamine neurons. U UngerstedtEur J Pharmacol19685718510Yes
323911681168.039.4239.4beta-Lactamases in laboratory and clinical resistance. D M LivermoreClin Microbiol Rev19958665470No
324046721168.0108.8127.2Base-calling of automated sequencer traces using phred. I. Accuracy assessment. B Ewing, L Hillier, M C Wendl, P GreenGenome Res19989521921Yes
324111681168.017.4417.4The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. R E Hope-SimpsonProc R Soc Med196514267505Yes
324211671167.045.145.1Freezing of living cells: mechanisms and implications. P MazurAm J Physiol19846383068No
324311671167.026.8426.8Neurons with graded response have collective computational properties like those of two-state neurons. J J HopfieldProc Natl Acad Sci U S A19846587342Yes
324423341167.049.3424.7Functions of lipid rafts in biological membranes. D A Brown, E LondonAnnu Rev Cell Dev Biol19989891780No
324511671167.023.623.6Liver regeneration: from myth to mechanism. Rebecca TaubNat Rev Mol Cell Biol200415459664No
324635001166.7106.6135.5Development and applications of CRISPR-Cas9 for genome engineering. Patrick D Hsu, Eric S Lander, Feng ZhangCell201424906146No
324734981166.0140.8446.9Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. A DeLean, P J Munson, D RodbardAm J Physiol1978686171Yes
324811661166.048.7748.8A spreading-activation theory of retrieval in sentence production. G S DellPsychol Rev19863749399Yes
324911661166.044.2644.3Molecular aspects of ligand binding to serum albumin. U Kragh-HansenPharmacol Rev19817027277No
325011661166.00.00.0A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. J B BrownBiochem J195514389222Yes
325111651165.051.0651.1Coping theory and research: past, present, and future. R S LazarusPsychosom Med19938346332No
325211651165.020.020.0Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. M S WoldAnnu Rev Biochem19979242902No
325311651165.034.6534.6Low-molecular-weight heparins. J I WeitzN Engl J Med19979278467No
325411651165.00.00.0The cytoarchitectonic organization of the spinal cord in the cat. B RexedJ Comp Neurol195214946260Yes
325511641164.026.1126.1Cadherins: a molecular family important in selective cell-cell adhesion. M TakeichiAnnu Rev Biochem19902197976No
325611641164.011.5311.5Pathologic anatomy of the pancreas in juvenile diabetes mellitus. W GeptsDiabetes19655318831Yes
325723281164.054.6727.3Endometriosis. Linda C Giudice, Lee C KaoLancet200415541453No
325823281164.054.5527.3ZINC--a free database of commercially available compounds for virtual screening. John J Irwin, Brian K ShoichetJ Chem Inf Model200515667143Yes
325911641164.032.932.9Rethinking schizophrenia. Thomas R InselNature201021068826No
326069831163.8155.7626.0Principal components analysis corrects for stratification in genome-wide association studies. Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David ReichNat Genet200616862161Yes
326169821163.7201.5633.6The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis. A Miyake, N P Friedman, M J Emerson, A H Witzki, A Howerter, T D WagerCogn Psychol200010945922Yes
326223271163.568.4234.2The capacity of visual working memory for features and conjunctions. S J Luck, E K VogelNature19979384378Yes
326323271163.548.1924.1Protein aggregation and neurodegenerative disease. Christopher A Ross, Michelle A PoirierNat Med200415272267No
326423271163.549.6424.8Defining the role of mTOR in cancer. David A Guertin, David M SabatiniCancer Cell200717613433No
326523271163.599.9950.0The lifelong effects of early childhood adversity and toxic stress. Jack P Shonkoff, Andrew S GarnerPediatrics201222201156Yes
326611631163.030.8330.8Presynaptic regulation of catecholamine release. S Z LangerBiochem Pharmacol19744617579No
326734891163.078.026.0Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. A L Shapiro, E Viñuela, J V MaizelBiochem Biophys Res Commun19674861258Yes
326811631163.031.6631.7Pharmacology of cannabinoid CB1 and CB2 receptors. R G PertweePharmacol Ther19979336020No
326934891163.095.6531.9Regulation of cancer cell metabolism. Rob A Cairns, Isaac S Harris, Tak W MakNat Rev Cancer201121258394No
327011631163.0102.59102.6The STROBE guidelines. Sarah CuschieriSaudi J Anaesth201930930717No
327123241162.098.0449.0Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. Peter C Austin, Elizabeth A StuartStat Med201526238958No
327234851161.788.4229.5The widespread regulation of microRNA biogenesis, function and decay. Jacek Krol, Inga Loedige, Witold FilipowiczNat Rev Genet201020661255No
327323231161.567.0133.5Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. P Brugada, J BrugadaJ Am Coll Cardiol19921309182Yes
327423231161.550.1225.1Lymphocyte homing and homeostasis. E C Butcher, L J PickerScience19968600538No
327511611161.056.6356.6The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. G A IlizarovClin Orthop Relat Res19892910611Yes
327611611161.034.7434.7Effect of anoxia on ion distribution in the brain. A J HansenPhysiol Rev19853880896No
327723221161.055.0827.5Toxoplasmosis. J G Montoya, O LiesenfeldLancet200415194258No
327811611161.021.3521.4Biological robustness. Hiroaki KitanoNat Rev Genet200415520792No
327911611161.043.9844.0Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. L SjöströmJ Intern Med201323163728No
328023211160.543.8221.9Rho GTPases: biochemistry and biology. Aron B Jaffe, Alan HallAnnu Rev Cell Dev Biol200516212495No
328111601160.036.3936.4Molecular biology of steroid hormone synthesis. W L MillerEndocr Rev19883061784No
328223191159.551.025.5Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. N Sreerama, R W WoodyAnal Biochem200011112271Yes
328311591159.021.9421.9Microarray data normalization and transformation. John QuackenbushNat Genet200212454644No
328411591159.028.0128.0Mode of action of membrane active antimicrobial peptides. Yechiel ShaiBiopolymers200212491537No
328523181159.061.6230.8BODIPY dyes and their derivatives: syntheses and spectroscopic properties. Aurore Loudet, Kevin BurgessChem Rev200717924696Yes
328623161158.049.8224.9Deep tissue two-photon microscopy. Fritjof Helmchen, Winfried DenkNat Methods200516299478No
328711581158.00.00.0Comparing individual means in the analysis of variance. J W TukeyBiometrics194918151955Yes
328811571157.011.9311.9Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J AltmanJ Comp Neurol19695361244Yes
328923141157.070.3835.2Self-management education: history, definition, outcomes, and mechanisms. Kate R Lorig, Halsted HolmanAnn Behav Med200312867348No
329023131156.551.0325.5Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. William G Kaelin, Peter J RatcliffeMol Cell200818498744No
329111561156.015.1515.2The nature and significance of platelet products in human plasma. P WolfBr J Haematol19676025241Yes
329211561156.035.8635.9Strategies of antioxidant defense. H SiesEur J Biochem19937688300No
329311561156.022.1522.1Regulation of cadherin-mediated adhesion in morphogenesis. Barry M GumbinerNat Rev Mol Cell Biol200516025097No
329423121156.055.0727.5ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Benoît D'Autréaux, Michel B ToledanoNat Rev Mol Cell Biol200717848967No
329511561156.00.00.0Observations on the isolated phrenic nerve diaphragm preparation of the rat. E BulbringBr J Pharmacol Chemother194620999334Yes
329634671155.784.8228.3High resolution two-dimensional electrophoresis of basic as well as acidic proteins. P Z O'Farrell, H M Goodman, P H O'FarrellCell197723215Yes
329723111155.547.4423.7Plant pathogens and integrated defence responses to infection. J L Dangl, J D JonesNature200111459065No
329823111155.5157.6378.8An Overview of Heart Rate Variability Metrics and Norms. Fred Shaffer, J P GinsbergFront Public Health201729034226No
329911551155.055.9956.0Self-discrepancy: a theory relating self and affect. E T HigginsPsychol Rev19873615707Yes
330011551155.021.7321.7Biogenic amines and the states of sleep. M JouvetScience19694303225No
330111551155.022.0222.0RNA metabolism in the HeLa cell nucleus. S PenmanJ Mol Biol19665961144Yes
330211551155.029.4429.4The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. R A JainBiomaterials200011055295No
330311551155.025.8625.9Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. H J DargieLancet200111356434Yes
330423101155.029.9515.0A Generalization Of The Retention Index System Including Linear Temperature Programmed Gas-Liquid Partition Chromatography. H Vandendool, P D KratzJ Chromatogr196314062605Yes
330523091154.564.8432.4Growth of a rat neuroblastoma cell line in serum-free supplemented medium. J E Bottenstein, G H SatoProc Natl Acad Sci U S A1979284369Yes
330623091154.539.3219.7Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. R W Butcher, E W SutherlandJ Biol Chem196213875173Yes
330711541154.029.0629.1Two-stage model of memory trace formation: a role for "noisy" brain states. G BuzsákiNeuroscience19892687720No
330811541154.043.043.0Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. J T DaugirdasJ Am Soc Nephrol19938305648Yes
330923081154.062.5231.3Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J A Sterne, M EggerJ Clin Epidemiol200111576817Yes
331023071153.543.6821.8NF-kappaB at the crossroads of life and death. Michael Karin, Anning LinNat Immunol200211875461No
331123071153.550.5725.3Esophageal cancer. Peter C Enzinger, Robert J MayerN Engl J Med200314657432No
331223071153.5105.2552.6Functional Classification and Experimental Dissection of Long Noncoding RNAs. Florian Kopp, Joshua T MendellCell201829373828No
331323051152.578.5639.3A simple index of Crohn's-disease activity. R F Harvey, J M BradshawLancet19806102236Yes
331423051152.551.7125.9The Polycomb complex PRC2 and its mark in life. Raphaël Margueron, Danny ReinbergNature201121248841No
331511521152.060.3160.3A "rationalized" arcsine transform. G A StudebakerJ Speech Hear Res19854046587Yes
331611521152.026.7226.7Amyloid, the presenilins and Alzheimer's disease. J HardyTrends Neurosci19979106355No
331723041152.051.7525.9Shape-controlled synthesis of gold and silver nanoparticles. Yugang Sun, Younan XiaScience200212481134Yes
331811521152.00.00.0The powerful placebo. H K BeecherJ Am Med Assoc195513271123Yes
331911521152.024.0924.1Version 1.2 of the Crystallography and NMR system. Axel T BrungerNat Protoc200718007608Yes
332011521152.025.3425.3Next-generation DNA sequencing methods. Elaine R MardisAnnu Rev Genomics Hum Genet200818576944No
332111521152.030.8230.8AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. D Grahame HardieGenes Dev201121937710No
332223031151.546.4123.2A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. N C Andrews, D V FallerNucleic Acids Res19912041787Yes
332323031151.551.325.6Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. P van den Driessche, James WatmoughMath Biosci200212387915Yes
332423031151.551.1425.6microRNA functions. Natascha Bushati, Stephen M CohenAnnu Rev Cell Dev Biol200717506695No
332523021151.071.0335.5Role of oxidized low density lipoprotein in atherogenesis. J L Witztum, D SteinbergJ Clin Invest19911752940No
332611511151.035.9636.0Relations between the statistics of natural images and the response properties of cortical cells. D J FieldJ Opt Soc Am A19873430225Yes
332723021151.066.7833.4Excitatory amino acids as a final common pathway for neurologic disorders. S A Lipton, P A RosenbergN Engl J Med19947905600No
332811511151.025.1125.1r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock. Michael J SandersonBioinformatics200312538260Yes
332911501150.021.9521.9Contingent genetic regulatory events in T lymphocyte activation. G R CrabtreeScience19892783497Yes
333011501150.027.2227.2Selective coronary arteriography. I. A percutaneous transfemoral technic. M P JudkinsRadiology19676048074Yes
333134501150.098.5932.9A sensitive and reliable locomotor rating scale for open field testing in rats. D M Basso, M S Beattie, J C BresnahanJ Neurotrauma19957783230Yes
333211501150.031.4331.4Leishmaniasis. B L HerwaldtLancet199910513726No
333311501150.00.00.0A sensitive method for the assay of 5-hydroxytryptamine. J R VaneBr J Pharmacol Chemother195713460242Yes
333411501150.046.8746.9How does sexual minority stigma "get under the skin"? A psychological mediation framework. Mark L HatzenbuehlerPsychol Bull200919702379No
333511491149.024.1124.1Stem cells in the central nervous system. R McKayScience19979082987No
333611491149.022.3422.3Inferences, questions and possibilities in Toll-like receptor signalling. Bruce BeutlerNature200415241424No
333711491149.023.4323.4Understanding the odd science of aging. Thomas B L KirkwoodCell200515734677No
333811491149.027.9628.0Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. Christof M NiemeyerAngew Chem Int Ed Engl200129712109No
333911481148.034.3434.3Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. D B ClewellJ Bacteriol19724336693Yes
334022961148.050.725.4Plasminogen: purification from human plasma by affinity chromatography. D G Deutsch, E T MertzScience19705475635Yes
334111481148.022.0122.0Mechanisms and consequences of activation of protein kinase B/Akt. J DownwardCurr Opin Cell Biol19989561851No
334211481148.024.9524.9G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. Jeffery T DavisAngew Chem Int Ed Engl200414755695No
334311481148.026.5426.5Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Richard C ScarpullaPhysiol Rev200818391175No
334422951147.585.6642.8Societal and individual determinants of medical care utilization in the United States. R Andersen, J F NewmanMilbank Mem Fund Q Health Soc19734198894Yes
334522951147.576.8938.4Pharmaceuticals and personal care products in the environment: agents of subtle change? C G Daughton, T A TernesEnviron Health Perspect199910592150No
334611471147.020.3220.3Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Eric C LaiNat Genet200211896390Yes
334722941147.064.0132.0Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Patrick S Ward, Craig B ThompsonCancer Cell201222439925No
334811461146.031.1231.1Diseases of the mitochondrial DNA. D C WallaceAnnu Rev Biochem19921497308No
334911461146.026.7726.8Aptamers: an emerging class of molecules that rival antibodies in diagnostics. S D JayasenaClin Chem199910471678No
335011461146.031.4631.5Riddle of biofilm resistance. K LewisAntimicrob Agents Chemother200111257008No
335111461146.0131.79131.8COVID-19 Vaccine Hesitancy Worldwide: A Concise Systematic Review of Vaccine Acceptance Rates. Malik SallamVaccines (Basel)202133669441No
335211451145.031.9431.9DNA topoisomerases. M GellertAnnu Rev Biochem19816267993No
335311451145.09.759.8A New Serum Type System In Man--The Lp System. K BergActa Pathol Microbiol Scand196314064818Yes
335411451145.00.00.0Fertilizing capacity of spermatozoa deposited into the fallopian tubes. M C ChangNature195114882325Yes
335511451145.033.8133.8Cognitive and affective development in adolescence. Laurence SteinbergTrends Cogn Sci200515668099No
335622901145.065.7932.9Relaxing the rule of ten events per variable in logistic and Cox regression. Eric Vittinghoff, Charles E McCullochAm J Epidemiol200717182981Yes
335722901145.072.6136.3Long non-coding RNAs: new players in cell differentiation and development. Alessandro Fatica, Irene BozzoniNat Rev Genet201424296535No
335811441144.045.1545.1Radioimmunological determination of human C-peptide in serum. L G HedingDiabetologia19751239396Yes
335911441144.042.1542.1Omega-3 fatty acids in health and disease and in growth and development. A P SimopoulosAm J Clin Nutr19911908631No
336022881144.066.9633.5Nitric oxide synthases in mammals. R G Knowles, S MoncadaBiochem J19947510950No
336145761144.0110.7227.7Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. H Nielsen, J Engelbrecht, S Brunak, G von HeijneProtein Eng19979051728Yes
336211441144.021.621.6The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. Y YardenEur J Cancer200111597398No
336322881144.066.9133.5Health effects of fine particulate air pollution: lines that connect. C Arden Pope, Douglas W DockeryJ Air Waste Manag Assoc200616805397No
336411441144.031.9331.9Neurophysiological and computational principles of cortical rhythms in cognition. Xiao-Jing WangPhysiol Rev201020664082No
336534301143.391.9730.7Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Robert G Hart, Lesly A Pearce, Maria I AguilarAnn Intern Med200717577005Yes
336622861143.061.3430.7Mechanisms of biofilm resistance to antimicrobial agents. T F Mah, G A O'TooleTrends Microbiol200111166241No
336711431143.025.6425.6Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. Michael J SandersonMol Biol Evol200211752195Yes
336811431143.036.4736.5Social support and health: a review of physiological processes potentially underlying links to disease outcomes. Bert N UchinoJ Behav Med200616758315No
336968561142.7156.5326.1Staging of brain pathology related to sporadic Parkinson's disease. Heiko Braak, Kelly Del Tredici, Udo Rüb, Rob A I de Vos, Ernst N H Jansen Steur, Eva BraakNeurobiol Aging200312498954Yes
337034261142.0108.5936.2Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. G M Wahl, M Stern, G R StarkProc Natl Acad Sci U S A1979291033Yes
337111421142.023.8423.8Evolution of ageing. T B KirkwoodNature1977593350Yes
337211421142.031.2831.3An improved fluorometric assay for DNA. R T HinegardnerAnal Biochem19715544593Yes
337322841142.060.430.2Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. M J Casadaban, S N CohenJ Mol Biol19806997493Yes
337411421142.033.3633.4Reducing children's television viewing to prevent obesity: a randomized controlled trial. T N RobinsonJAMA199910546696Yes
337511421142.028.0928.1Formation and function of the myofibroblast during tissue repair. Boris HinzJ Invest Dermatol200717299435No
337611421142.028.0528.1Immortal time bias in pharmaco-epidemiology. Samy SuissaAm J Epidemiol200818056625No
337722841142.061.4830.7Mechanisms of mitophagy. Richard J Youle, Derek P NarendraNat Rev Mol Cell Biol201121179058No
337822841142.072.036.0Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Thomas A Wynn, Thirumalai R RamalingamNat Med201222772564No
337922831141.544.722.4Tumour-cell invasion and migration: diversity and escape mechanisms. Peter Friedl, Katarina WolfNat Rev Cancer200312724734No
338022821141.042.5821.3The druggable genome. Andrew L Hopkins, Colin R GroomNat Rev Drug Discov200212209152No
338111411141.047.7147.7CONSORT-EHEALTH: improving and standardizing evaluation reports of Web-based and mobile health interventions. Gunther EysenbachJ Med Internet Res201122209829No
338222801140.046.7823.4Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. G A Gonzalez, M R MontminyCell19892573431Yes
338311401140.038.5938.6Selective attention and the organization of visual information. J DuncanJ Exp Psychol Gen19846240521Yes
338411401140.025.8125.8Viruses in the sea. Curtis A SuttleNature200516163346No
338511401140.00.00.0Knee joint changes after meniscectomy. T J FairbankJ Bone Joint Surg Br194818894618Yes
338611391139.020.5120.5Shrinkage necrosis: a distinct mode of cellular death. J F KerrJ Pathol19714108566Yes
338711391139.021.3621.4The power and the promise of DNA methylation markers. Peter W LairdNat Rev Cancer200312671664No
338811391139.030.3830.4Disseminating innovations in health care. Donald M BerwickJAMA200312697800Yes
338911391139.022.7922.8Diffusion-in-gel methods for immunological analysis. II. O OuchterlonyProg Allergy196214482809Yes
339011391139.030.7830.8Stronger Brønsted acids. Takahiko AkiyamaChem Rev200717983247Yes
339111391139.00.00.0A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. R D HotchkissArch Biochem194818921848Yes
339211391139.075.6575.7Cell death: a review of the major forms of apoptosis, necrosis and autophagy. Mark S D'ArcyCell Biol Int201930958602No
339345551138.8249.1262.3The Cambridge Structural Database. Colin R Groom, Ian J Bruno, Matthew P Lightfoot, Suzanna C WardActa Crystallogr B Struct Sci Cryst Eng Mater201627048719Yes
339411381138.028.6828.7Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. I J FidlerCancer Res19901698118Yes
339511381138.033.8133.8Unstable angina. A classification. E BraunwaldCirculation19892752565Yes
339611381138.053.0753.1Analysis of Fickian and non-Fickian drug release from polymers. N A PeppasPharm Acta Helv19854011621Yes
339711381138.040.3440.3Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. W A CatterallAnnu Rev Pharmacol Toxicol19806247957No
339811381138.025.7825.8The columnar organization of the neocortex. V B MountcastleBrain19979153131No
339911381138.045.5845.6The anatomy of stages of change. A BanduraAm J Health Promot199710170438No
340011381138.032.6132.6The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. S Nolen-HoeksemaJ Abnorm Psychol200011016119Yes
340111381138.023.9924.0Molecular imaging of cancer with positron emission tomography. Sanjiv Sam GambhirNat Rev Cancer200212209157No
340211381138.030.6230.6A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Ron HardmanEnviron Health Perspect200616451849No
340334121137.382.1627.4Mechanisms linking obesity to insulin resistance and type 2 diabetes. Steven E Kahn, Rebecca L Hull, Kristina M UtzschneiderNature200617167471No
340411371137.027.6727.7Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. S G JohnsenHormones19705527187Yes
340522741137.089.8444.9Statistical methods for assessing measurement error (reliability) in variables relevant to sports medicine. G Atkinson, A M NevillSports Med19989820922No
340611371137.030.8430.8Venous thrombosis: a multicausal disease. F R RosendaalLancet199910209995No
340711371137.016.6416.6Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. R J PenningtonBiochem J196113734134Yes
340822731136.544.322.1Homeobox genes and axial patterning. W McGinnis, R KrumlaufCell19921346368No
340911361136.026.726.7Mechanisms of lipid peroxide formation in animal tissues. E D WillsBiochem J19665964963Yes
341011361136.021.7421.7VEGF and the quest for tumour angiogenesis factors. Napoleone FerraraNat Rev Cancer200212360282No
341122721136.051.2225.6Next-generation DNA sequencing. Jay Shendure, Hanlee JiNat Biotechnol200818846087Yes
341211351135.036.2536.2Predictors of postpartum depression: an update. C T BeckNurs Res200111570712Yes
341345401135.0111.3227.8Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod MenonProc Natl Acad Sci U S A200312506194Yes
341411351135.035.2635.3Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Ronald A HitesEnviron Sci Technol200414998004Yes
341511351135.020.1920.2NFAT proteins: key regulators of T-cell development and function. Fernando MacianNat Rev Immunol200515928679No
341622701135.071.8135.9Central sensitization: a generator of pain hypersensitivity by central neural plasticity. Alban Latremoliere, Clifford J WoolfJ Pain200919712899No
341734041134.791.630.5Cytochemical identification of monocytes and granulocytes. L T Yam, C Y Li, W H CrosbyAm J Clin Pathol19715549896Yes
341834041134.772.524.2A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. M Serrano, G J Hannon, D BeachNature19938259215Yes
341922691134.575.6637.8The complexity of NF-κB signaling in inflammation and cancer. Bastian Hoesel, Johannes A SchmidMol Cancer201323915189No
342011341134.023.1523.1Differentiation and proliferation of hematopoietic stem cells. M OgawaBlood19938499622No
342134021134.067.3522.4SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. Jay D Horton, Joseph L Goldstein, Michael S BrownJ Clin Invest200211994399No
342211341134.059.8959.9The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Martins EkorFront Pharmacol201424454289No
342322671133.558.4729.2Protein oxidation in aging, disease, and oxidative stress. B S Berlett, E R StadtmanJ Biol Chem19979252331No
342422671133.50.00.0Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. H H Ussing, K ZerahnActa Physiol Scand195114868510Yes
342579321133.1246.435.2Toxicity and response criteria of the Eastern Cooperative Oncology Group. M M Oken, R H Creech, D C Tormey, J Horton, T E Davis, E T McFadden, P P CarboneAm J Clin Oncol19827165009Yes
342633991133.0121.140.4Neighborhoods and violent crime: a multilevel study of collective efficacy. R J Sampson, S W Raudenbush, F EarlsScience19979252316Yes
342711331133.020.9420.9Regulation of phosphoinositide-specific phospholipase C. S G RheeAnnu Rev Biochem200111395409No
342822651132.543.5921.8STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Hiroki Ishikawa, Glen N BarberNature200818724357Yes
342945301132.5212.9453.2Genome sequence-based species delimitation with confidence intervals and improved distance functions. Jan P Meier-Kolthoff, Alexander F Auch, Hans-Peter Klenk, Markus GökerBMC Bioinformatics201323432962Yes
343011321132.021.5721.6Structure of chromatin. R D KornbergAnnu Rev Biochem1977332067No
343111321132.032.1132.1Cholesterol and the cell membrane. P L YeagleBiochim Biophys Acta19853904832No
343211321132.032.932.9Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. P S ToftsJ Magn Reson Imaging19979039598No
343333961132.090.630.2A nonparametric method for automatic correction of intensity nonuniformity in MRI data. J G Sled, A P Zijdenbos, A C EvansIEEE Trans Med Imaging19989617910Yes
343411321132.020.2520.2The development of neural stem cells. S TempleNature200111689956No
343511321132.028.7428.7Ovarian cancer development and metastasis. Ernst LengyelAm J Pathol201020651229Yes
343622631131.559.6429.8Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. I Chopra, M RobertsMicrobiol Mol Biol Rev200111381101Yes
343722621131.050.2625.1Obesity and insulin resistance. B B Kahn, J S FlierJ Clin Invest200010953022No
343811311131.029.6629.7Time is brain--quantified. Jeffrey L SaverStroke200616339467Yes
343922621131.0136.868.4Breast Cancer Treatment: A Review. Adrienne G Waks, Eric P WinerJAMA201930667505No
344022611130.575.8937.9Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. A E Czeizel, I DudásN Engl J Med19921307234Yes
344111301130.031.2631.3Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units. C M VenkatachalamBiopolymers19685685102Yes
344211301130.026.0726.1Allelic discrimination using fluorogenic probes and the 5' nuclease assay. K J LivakGenet Anal199910084106Yes
344322601130.049.1724.6Regeneration beyond the glial scar. Jerry Silver, Jared H MillerNat Rev Neurosci200414735117No
344411301130.024.0424.0VEGF as a key mediator of angiogenesis in cancer. Peter CarmelietOncology200516301830No
344522601130.050.9225.5Modes of resistance to anti-angiogenic therapy. Gabriele Bergers, Douglas HanahanNat Rev Cancer200818650835No
344611301130.00.00.0pA, a new scale for the measurement of drug antagonism. H O SchildBr J Pharmacol Chemother194720258355Yes
344711301130.040.4540.5Visual attention: the past 25 years. Marisa CarrascoVision Res201121549742No
344833881129.390.0730.0Improved vectors and genome-wide libraries for CRISPR screening. Neville E Sanjana, Ophir Shalem, Feng ZhangNat Methods201425075903Yes
344911291129.024.9124.9Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. M KozakNucleic Acids Res19817301588Yes
345011291129.00.00.0The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. J VagueAm J Clin Nutr195613282851Yes
345122571128.577.7538.9A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. Walter J Paulus, Carsten TschöpeJ Am Coll Cardiol201323684677No
345211281128.023.7423.7Mutator phenotype may be required for multistage carcinogenesis. L A LoebCancer Res19912039987No
345322561128.082.741.4The Modified Mini-Mental State (3MS) examination. E L Teng, H C ChuiJ Clin Psychiatry19873611032Yes
345411281128.028.5828.6Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. M M WeiserJ Biol Chem19734698230Yes
345511281128.042.7442.7On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. D CollenThromb Haemost19806450468No
345611281128.022.1422.1Regulation of transcription by MAP kinase cascades. R TreismanCurr Opin Cell Biol19968791420No
345722561128.055.0927.5The protective effects of estrogen on the cardiovascular system. M E Mendelsohn, R H KarasN Engl J Med199910362825No
345811281128.020.5120.5DNA methylation in cancer: too much, but also too little. Melanie EhrlichOncogene200212154403No
345911281128.00.00.0Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. A B StavitskyJ Immunol195413163409Yes
346011281128.017.3217.3Inherited Antithrombin Deficiency Causing Thrombophilia. O EgebergThromb Diath Haemorrh196514347873Yes
346111281128.00.00.0The Stability of Broken Ends of Chromosomes in Zea Mays. B McClintockGenetics194117247004Yes
346211281128.022.422.4Models, mechanisms and clinical evidence for cancer dormancy. Julio A Aguirre-GhisoNat Rev Cancer200717957189No
346311281128.032.2932.3A comprehensive definition for metabolic syndrome. Paul L HuangDis Model Mech200919407331No
346433831127.796.3532.1Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Geoffrey R Norman, Jeff A Sloan, Kathleen W WyrwichMed Care200312719681No
346511271127.067.8367.8Cytoprotection by prostaglandins. A RobertGastroenterology197938173Yes
346622541127.084.6642.3The Posttraumatic Growth Inventory: measuring the positive legacy of trauma. R G Tedeschi, L G CalhounJ Trauma Stress19968827649Yes
346722541127.059.3129.7Fitness effects on the cognitive function of older adults: a meta-analytic study. Stanley Colcombe, Arthur F KramerPsychol Sci200312661673Yes
346822531126.532.7816.4Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. L M Siegel, K J MontyBiochim Biophys Acta19665329026Yes
346922531126.584.0342.0Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. I B Wilson, P D ClearyJAMA19957996652Yes
347033791126.3104.4334.8PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. J W Varni, M Seid, P S KurtinMed Care200111468499Yes
347111261126.023.7623.8Molecular cloning and expression of glycogen synthase kinase-3/factor A. J R WoodgettEMBO J19902164470Yes
347211261126.023.8823.9Fluorescence spectroscopy of single biomolecules. S WeissScience199910073925No
347311261126.037.937.9Globalization of diabetes: the role of diet, lifestyle, and genes. Frank B HuDiabetes Care201121617109No
347433771125.790.5430.2Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. R Schreck, P Rieber, P A BaeuerleEMBO J19912065663Yes
347522511125.592.2946.1Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. L A Clark, D WatsonJ Abnorm Psychol19911918611No
347611251125.051.7151.7Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder. M RutterBr J Psychiatry19853830321Yes
347722501125.058.8329.4A rating scale for extrapyramidal side effects. G M Simpson, J W AngusActa Psychiatr Scand Suppl19704917967Yes
347822501125.046.1223.1Genomic control for association studies. B Devlin, K RoederBiometrics199911315092Yes
347922481124.078.039.0A formula to estimate the approximate surface area if height and weight be known. 1916. D Du Bois, E F Du BoisNutrition19892520314No
348022481124.059.1529.6Oxidative stress, caloric restriction, and aging. R S Sohal, R WeindruchScience19968658196No
348122481124.047.9324.0Roles of CHOP/GADD153 in endoplasmic reticulum stress. S Oyadomari, M MoriCell Death Differ200414685163No
348211241124.030.6630.7Cholinesterase inhibitors for Alzheimer's disease. J BirksCochrane Database Syst Rev200616437532No
348311241124.056.8856.9Systematic text condensation: a strategy for qualitative analysis. Kirsti MalterudScand J Public Health201223221918Yes
3484112361123.6254.5725.5Scalable molecular dynamics with NAMD. James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kalé, Klaus SchultenJ Comput Chem200516222654Yes
348544941123.5108.0427.0C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. P M Ridker, C H Hennekens, J E Buring, N RifaiN Engl J Med200010733371Yes
348622471123.554.6127.3Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Herbert Tilg, Alexander R MoschenNat Rev Immunol200616998510No
348722471123.551.7725.9The host defense of Drosophila melanogaster. Bruno Lemaitre, Jules HoffmannAnnu Rev Immunol200717201680No
348844931123.2103.625.9SCOP: a structural classification of proteins database for the investigation of sequences and structures. A G Murzin, S E Brenner, T Hubbard, C ChothiaJ Mol Biol19957723011Yes
348911231123.049.7149.7Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. S Z LangerBr J Pharmacol197720190No
349011231123.038.3338.3Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. A R MidgleyEndocrinology19665950482Yes
349111231123.032.932.9Cell surface interactions with extracellular materials. K M YamadaAnnu Rev Biochem19836351729No
349211231123.023.4323.4ALSCRIPT: a tool to format multiple sequence alignments. G J BartonProtein Eng19938433969Yes
349322451122.563.8231.9Strategies in the design of nanoparticles for therapeutic applications. Robby A Petros, Joseph M DeSimoneNat Rev Drug Discov201020616808No
349456101122.0110.9722.2Electrostatics of nanosystems: application to microtubules and the ribosome. N A Baker, D Sept, S Joseph, M J Holst, J A McCammonProc Natl Acad Sci U S A200111517324Yes
349511211121.030.0330.0The chromosomal basis of human neoplasia. J J YunisScience19836336310Yes
349622421121.065.3432.7Are the dorsal and ventral hippocampus functionally distinct structures? Michael S Fanselow, Hong-Wei DongNeuron201020152109No
349722411120.562.2731.1Burden of major musculoskeletal conditions. Anthony D Woolf, Bruce PflegerBull World Health Organ200314710506No
349811201120.032.032.0Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. S IrwinPsychopharmacologia19685679627Yes
349944801120.0145.1936.3The cholinergic hypothesis of geriatric memory dysfunction. R T Bartus, R L Dean, B Beer, A S LippaScience19827046051No
350011201120.025.8425.8Anatomy and regulation of the central melanocortin system. Roger D ConeNat Neurosci200515856065No
350111201120.025.9826.0Solid-state nanopores. Cees DekkerNat Nanotechnol200718654264No
350267191119.8145.3824.2Obesity is associated with macrophage accumulation in adipose tissue. Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W FerranteJ Clin Invest200314679176Yes
350322391119.558.9929.5Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. R A Ignotz, J MassaguéJ Biol Chem19863456347Yes
350411191119.032.7832.8Animal mitochondrial DNA: structure and evolution. D R WolstenholmeInt Rev Cytol19921452431No
350511191119.034.4934.5Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J E OesterlingJ Urol19911707989No
350611191119.024.6424.6Lithium batteries and cathode materials. M Stanley WhittinghamChem Rev200415669156Yes
350722381119.084.0842.0Long Noncoding RNAs in Cancer Pathways. Adam M Schmitt, Howard Y ChangCancer Cell201627070700No
350833551118.392.8631.0Spirometric reference values from a sample of the general U.S. population. J L Hankinson, J R Odencrantz, K B FedanAm J Respir Crit Care Med19999872837Yes
350911181118.039.5839.6Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. J N WasserheitSex Transm Dis19921595015No
351022361118.045.0722.5RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. M B Shapiro, P SenapathyNucleic Acids Res19873658675Yes
351111181118.037.1637.2Chemoprevention of cancer. L W WattenbergCancer Res19853880665No
351211181118.056.7256.7Osseointegration and its experimental background. P I BrånemarkJ Prosthet Dent19836352924No
351322361118.076.3338.2Consensus methods for medical and health services research. J Jones, D HunterBMJ19957640549No
351422361118.048.7824.4Prediction of protein secondary structure at better than 70% accuracy. B Rost, C SanderJ Mol Biol19938345525Yes
351511181118.020.7520.8The ubiquitin-proteasome pathway: on protein death and cell life. A CiechanoverEMBO J19989857172No
351622361118.038.6219.3A synthetic oscillatory network of transcriptional regulators. M B Elowitz, S LeiblerNature200010659856Yes
351711181118.037.637.6A review of psychological risk factors in back and neck pain. S J LintonSpine (Phila Pa 1976)200010788861No
351811181118.027.7127.7Seed Germination and Dormancy. J. D. BewleyPlant Cell199712237375Yes
351911181118.040.2340.2The pathobiology of vascular dementia. Costantino IadecolaNeuron201324267647No
352011171117.028.6328.6Linkage strategies for genetically complex traits. I. Multilocus models. N RischAm J Hum Genet19902301392Yes
352111171117.031.0831.1On the utility of P3 amplitude as a measure of processing capacity. A KokPsychophysiology200111352145No
352211171117.026.1926.2Differential projections of the infralimbic and prelimbic cortex in the rat. Robert P VertesSynapse200414579424Yes
352322341117.067.233.6Ischemia and reperfusion--from mechanism to translation. Holger K Eltzschig, Tobias EckleNat Med201122064429No
352422331116.544.9822.5A survey of telomerase activity in human cancer. J W Shay, S BacchettiEur J Cancer19979282118No
352544661116.5220.4155.1NF-κB signaling in inflammation. Ting Liu, Lingyun Zhang, Donghyun Joo, Shao-Cong SunSignal Transduct Target Ther201729158945Yes
352611161116.052.3552.4Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Y KonoArch Biochem Biophys197824422Yes
352711161116.034.7134.7Protein damage and degradation by oxygen radicals. I. general aspects. K J DaviesJ Biol Chem19873036875Yes
352811161116.034.0334.0Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. P J BasserNMR Biomed19958739270No
352922321116.052.8126.4Reducing the dimensionality of data with neural networks. G E Hinton, R R SalakhutdinovScience200616873662Yes
353011161116.026.7126.7What is a support vector machine? William S NobleNat Biotechnol200617160063No
353111161116.030.9130.9The locus coeruleus and noradrenergic modulation of cognition. Susan J SaraNat Rev Neurosci200919190638No
353211151115.033.333.3Studies on histones. 7. Preparative methods for histone fractions from calf thymus. E W JohnsBiochem J19645840387Yes
353311151115.033.0133.0Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. M J GassonJ Bacteriol19836403500Yes
353411151115.026.6226.6Molecular drive: a cohesive mode of species evolution. G DoverNature19827110332Yes
353511151115.036.7436.7Socioeconomic disadvantage and child development. V C McLoydAm Psychol19989491747No
353655741114.8264.2652.9CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes. Donovan H Parks, Michael Imelfort, Connor T Skennerton, Philip Hugenholtz, Gene W TysonGenome Res201525977477Yes
353722291114.564.6532.3A fast, lock-free approach for efficient parallel counting of occurrences of k-mers. Guillaume Marçais, Carl KingsfordBioinformatics201121217122Yes
353811141114.027.8927.9Sex-hormone-binding globulin. D C AndersonClin Endocrinol (Oxf)19744134992No
353922281114.049.6424.8Synaptic activity and the construction of cortical circuits. L C Katz, C J ShatzScience19968895456No
354033421114.077.0225.7Obesity induces a phenotypic switch in adipose tissue macrophage polarization. Carey N Lumeng, Jennifer L Bodzin, Alan R SaltielJ Clin Invest200717200717Yes
354122281114.080.8340.4Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. Claudio Franceschi, Judith CampisiJ Gerontol A Biol Sci Med Sci201424833586No
354211131113.040.1840.2Methods for dealing with reaction time outliers. R RatcliffPsychol Bull19938272468Yes
354311131113.024.7524.8Current concepts of the pathogenesis of the acute coronary syndromes. P LibbyCirculation200111457759No
354422261113.088.444.2Communication by Extracellular Vesicles: Where We Are and Where We Need to Go. Mercedes Tkach, Clotilde ThéryCell201626967288No
354544511112.8116.8429.2Prevalence and trends in obesity among US adults, 1999-2000. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L JohnsonJAMA200212365955Yes
354622251112.579.5439.8Microdroplet Assay Of Human Serum Cytotoxins. P I Terasaki, J D McclellandNature196414248725Yes
354722241112.071.7235.9Wine, alcohol, platelets, and the French paradox for coronary heart disease. S Renaud, M de LorgerilLancet19921351198Yes
354822241112.069.3834.7Excitatory amino acid transmitters. J C Watkins, R H EvansAnnu Rev Pharmacol Toxicol19816112965No
354911121112.024.1824.2Toward self-organization and complex matter. Jean-Marie LehnScience200211923524Yes
355044481112.034.098.5The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. P J Randle, P B Garland, C N Hales, E A NewsholmeLancet196313990765Yes
355111121112.027.6127.6Pathogenesis of osteoporosis: concepts, conflicts, and prospects. Lawrence G RaiszJ Clin Invest200516322775No
355222241112.065.1932.6Chronic hepatitis B: update 2009. Anna S F Lok, Brian J McMahonHepatology200919714720Yes
355344481112.0127.2131.8GCTA: a tool for genome-wide complex trait analysis. Jian Yang, S Hong Lee, Michael E Goddard, Peter M VisscherAm J Hum Genet201121167468Yes
355466681111.3174.6429.1Prediction of coronary heart disease using risk factor categories. P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B KannelCirculation19989603539Yes
355522221111.051.9126.0Cellular uptake of the tat protein from human immunodeficiency virus. A D Frankel, C O PaboCell19882849510Yes
355611111111.025.5525.6Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis. M M TirionPhys Rev Lett199610063201Yes
355711111111.00.00.0A cytoarchitectonic atlas of the spinal cord in the cat. B RexedJ Comp Neurol195413163236Yes
355811111111.023.6123.6Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. Michael ForgacNat Rev Mol Cell Biol200717912264No
355911111111.022.8522.9Membrane recognition by phospholipid-binding domains. Mark A LemmonNat Rev Mol Cell Biol200818216767No
356022201110.034.2417.1Construction of phylogenetic trees. W M Fitch, E MargoliashScience19675334057No
356111101110.023.623.6Complement. Second of two parts. M J WalportN Engl J Med200111297706No
356211101110.021.0521.1Focal adhesion kinase: the first ten years. J Thomas ParsonsJ Cell Sci200312640026No
3563122101110.0344.631.3International physical activity questionnaire: 12-country reliability and validity. Cora L Craig, Alison L Marshall, Michael Sjöström, Adrian E Bauman, Michael L Booth, Barbara E Ainsworth, Michael Pratt, Ulf Ekelund, Agneta Yngve, James F Sallis, Pekka OjaMed Sci Sports Exerc200312900694Yes
356411101110.024.2824.3Personal genomes: The case of the missing heritability. Brendan MaherNature200818987709No
356522201110.066.6533.3Reactive oxygen species, cellular redox systems, and apoptosis. Magdalena L Circu, Tak Yee AwFree Radic Biol Med201020045723No
356611101110.052.9853.0Sleep health: can we define it? Does it matter? Daniel J BuysseSleep201424470692Yes
356733291109.777.6225.9Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis. Sang-Dong Yoo, Young-Hee Cho, Jen SheenNat Protoc200717585298Yes
356811091109.026.4126.4Quantification of beta-sheet amyloid fibril structures with thioflavin T. H LeVineMethods Enzymol199910507030Yes
356911091109.024.8224.8The impact of next-generation sequencing technology on genetics. Elaine R MardisTrends Genet200818262675No
357011081108.021.8121.8Cytokine receptor signalling. J N IhleNature19957566171No
357111081108.028.9829.0Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. F P GuengerichChem Res Toxicol200111409933No
357211081108.026.4326.4ImageJ for microscopy. Tony J CollinsBiotechniques200717936939No
357322151107.554.9527.5Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. R J Britten, D E KohneScience19684874239Yes
357433221107.398.8332.9HMMER web server: interactive sequence similarity searching. Robert D Finn, Jody Clements, Sean R EddyNucleic Acids Res201121593126Yes
357533221107.3231.4377.1MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization. Kazutaka Katoh, John Rozewicki, Kazunori D YamadaBrief Bioinform201928968734Yes
357611071107.043.3543.4A simple method for determination of serum catalase activity and revision of reference range. L GóthClin Chim Acta19912029780Yes
357711071107.019.7619.8Cell lines derived from late embryonic stages of Drosophila melanogaster. I SchneiderJ Embryol Exp Morphol19724625067Yes
357822141107.049.8224.9A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. J N Cohn, G TognoniN Engl J Med200111759645Yes
357922141107.058.129.1Localized surface plasmon resonance spectroscopy and sensing. Katherine A Willets, Richard P Van DuyneAnnu Rev Phys Chem200717067281No
358033181106.0111.8837.3Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. M Hamberg, J Svensson, B SamuelssonProc Natl Acad Sci U S A19751059088Yes
358111061106.022.222.2Primary response genes induced by growth factors and tumor promoters. H R HerschmanAnnu Rev Biochem19911883198No
358211061106.038.6938.7Spin trapping: ESR parameters of spin adducts. G R BuettnerFree Radic Biol Med19872826304No
358311061106.029.829.8What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. Michael A BabyakPsychosom Med200415184705Yes
358411061106.029.1429.1Abiotic stress, the field environment and stress combination. Ron MittlerTrends Plant Sci200616359910No
358511051105.021.2921.3Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. A S BaldwinJ Clin Invest200111160144No
358622091104.547.2123.6Finding and evaluating community structure in networks. M E J Newman, M GirvanPhys Rev E Stat Nonlin Soft Matter Phys200414995526Yes
358722091104.548.3624.2Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. Daniel J Hicklin, Lee M EllisJ Clin Oncol200515585754No
358811041104.023.1823.2A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. J MilbrandtScience19873672127Yes
358911041104.026.3926.4Cells in stress: transcriptional activation of heat shock genes. R I MorimotoScience19938451637No
359011041104.032.9633.0Social support and patient adherence to medical treatment: a meta-analysis. M Robin DiMatteoHealth Psychol200415008666Yes
359122081104.054.0727.0Quorum sensing: cell-to-cell communication in bacteria. Christopher M Waters, Bonnie L BasslerAnnu Rev Cell Dev Biol200516212498No
359211041104.026.2726.3Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. Thomas A WynnJ Clin Invest200717332879No
359344161104.0147.6636.9Prevalence and trends in obesity among US adults, 1999-2008. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R CurtinJAMA201020071471Yes
359411041104.029.0629.1An introduction to data reduction: space-group determination, scaling and intensity statistics. Philip R EvansActa Crystallogr D Biol Crystallogr201121460446Yes
359511041104.045.9145.9A comprehensive review on metabolic syndrome. Jaspinder KaurCardiol Res Pract201424711954No
359622081104.0119.0859.5Sexually transmitted diseases treatment guidelines, 2015. Kimberly A Workowski, Gail A BolanMMWR Recomm Rep201526042815No
359722071103.5243.18121.6Mental Health and the Covid-19 Pandemic. Betty Pfefferbaum, Carol S NorthN Engl J Med202032283003Yes
359811031103.032.5932.6Tests for emotionality in rats and mice: a review. J ArcherAnim Behav19734578750No
359911031103.023.2723.3Twilight zone of protein sequence alignments. B RostProtein Eng199910195279Yes
360011031103.00.00.0Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins. R D OwenScience194517755278Yes
360111031103.038.3438.3Epidemiology of heart failure. Véronique L RogerCirc Res201323989710No
360222041102.051.6425.8T antigen is bound to a host protein in SV40-transformed cells. D P Lane, L V CrawfordNature1979218111Yes
360311021102.025.225.2The prefrontal cortex--an update: time is of the essence. J M FusterNeuron200111394996No
360422041102.00.00.0Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. A H Coons, M H KaplanJ Exp Med195015395569Yes
360522031101.582.9141.5The content validity index: are you sure you know what's being reported? Critique and recommendations. Denise F Polit, Cheryl Tatano BeckRes Nurs Health200616977646Yes
360611011101.033.733.7Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. D L ColemanDiabetologia1978350680No
360711011101.027.3527.4The Trk family of neurotrophin receptors. M BarbacidJ Neurobiol19947852993No
360811011101.028.128.1Glutathione and its role in cellular functions. H SiesFree Radic Biol Med199910569624No
360911011101.022.9422.9Phenotypic plasticity and the epigenetics of human disease. Andrew P FeinbergNature200717522677No
361011011101.00.00.0Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent. D L MorrisScience194817814729Yes
361111011101.028.7628.8Bile acids: regulation of synthesis. John Y L ChiangJ Lipid Res200919346330No
361233021100.7156.752.2Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG) P L Hudak, P C Amadio, C BombardierAm J Ind Med19968773720Yes
361311001100.020.2520.2Chronic myeloid leukemia. C L SawyersN Engl J Med199910219069No
361411001100.028.0428.0Unequal treatment: confronting racial and ethnic disparities in health care. Alan NelsonJ Natl Med Assoc200212152921No
361532981099.398.5432.8Depression: a new animal model sensitive to antidepressant treatments. R D Porsolt, M Le Pichon, M JalfreNature1977559941Yes
361610991099.056.3456.3The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. G A IlizarovClin Orthop Relat Res19892912628Yes
361710991099.042.442.4The role of endothelium in the responses of vascular smooth muscle to drugs. R F FurchgottAnnu Rev Pharmacol Toxicol19846203480No
361821981099.048.9324.5Cell cycle control and cancer. L H Hartwell, M B KastanScience19947997877No
361932971099.085.9428.6Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. M K Parmar, V Torri, L StewartStat Med19989921604Yes
362010991099.019.919.9Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. R A FryeBiochem Biophys Res Commun200010873683Yes
362110991099.022.2222.2Osmotic stress signaling and osmoadaptation in yeasts. Stefan HohmannMicrobiol Mol Biol Rev200212040128No
362221971098.50.00.0Cortisone in ulcerative colitis; final report on a therapeutic trial. S C Truelove, L J WittsBr Med J195513260656Yes
362321971098.589.4644.7Macrophages in Tissue Repair, Regeneration, and Fibrosis. Thomas A Wynn, Kevin M VannellaImmunity201626982353No
362410981098.024.3624.4The molecular biology of leukocyte chemoattractant receptors. P M MurphyAnnu Rev Immunol19948011292No
362510981098.028.1228.1Neuropathology of Parkinson's disease. L S FornoJ Neuropathol Exp Neurol19968786384No
362610981098.025.4525.4BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data. O GascuelMol Biol Evol19979254330Yes
362721951097.545.622.8p53: puzzle and paradigm. L J Ko, C PrivesGenes Dev19968654922No
362810971097.054.0354.0The sociological study of stress. L I PearlinJ Health Soc Behav19892674272No
362910971097.027.7627.8Two distinct classes of carbohydrate-recognition domains in animal lectins. K DrickamerJ Biol Chem19883290208No
363021941097.082.5241.3Understanding face recognition. V Bruce, A YoungBr J Psychol19863756376Yes
363121941097.064.0832.0Mental rotation of three-dimensional objects. R N Shepard, J MetzlerScience19715540314Yes
363210971097.027.3927.4A kinetic photometric method for serum gamma-glutamyl transpeptidase. G SzaszClin Chem19695773262Yes
363310971097.019.6519.6Time-dependent processes in memory storage. J L McGaughScience19665917768Yes
363410971097.024.7124.7Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system. T IkemuraJ Mol Biol19816175758Yes
363510971097.030.8230.8Limbic-cortical dysregulation: a proposed model of depression. H S MaybergJ Neuropsychiatry Clin Neurosci19979276848No
363610971097.00.00.0Cleavage of the haem-protein link by acid methylethylketone. F W TealeBiochim Biophys Acta195913837237Yes
363710971097.00.00.0Motivation reconsidered: the concept of competence. R W WhitePsychol Rev195913844397Yes
363821941097.027.0713.5Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques. P Gold, S O FreedmanJ Exp Med196514270243Yes
363910971097.040.2140.2Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms. Tamás RőszerMediators Inflamm201526089604No
3640109661096.6361.9236.2The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. N K Aaronson, S Ahmedzai, B Bergman, M Bullinger, A Cull, N J Duez, A Filiberti, H Flechtner, S B Fleishman, J C de HaesJ Natl Cancer Inst19938433390Yes
364110961096.058.6958.7The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement. M M PanjabiJ Spinal Disord19921490034Yes
364210961096.029.9229.9Aging, energy, and oxidative stress in neurodegenerative diseases. M F BealAnn Neurol19957668820No
364310961096.032.332.3Spatially heterogeneous dynamics in supercooled liquids. M D EdigerAnnu Rev Phys Chem200011031277Yes
364410961096.00.00.0Asymptomatic infections of the urinary tract. E H KassTrans Assoc Am Physicians195613380946Yes
364510961096.027.4227.4Fibrinogen and fibrin structure and functions. M W MosessonJ Thromb Haemost200516102057No
364610961096.034.2834.3The collagen family. Sylvie Ricard-BlumCold Spring Harb Perspect Biol201121421911No
364721911095.563.2931.6The acute phase response. H Baumann, J GauldieImmunol Today19947512342No
364821911095.543.8621.9Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. P E Wright, H J DysonJ Mol Biol199910550212No
364921911095.50.00.0Micromethod for the direct determination of serum triglycerides. E Van Handel, D B ZilversmitJ Lab Clin Med195713439279Yes
365032851095.0117.4539.1Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. P S Walsh, D A Metzger, R HiguchiBiotechniques19911867860Yes
365110951095.020.720.7Luciferase reporter gene vectors for analysis of promoters and enhancers. S K NordeenBiotechniques19882908509Yes
365221901095.065.7432.92,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. A Poland, J C KnutsonAnnu Rev Pharmacol Toxicol19826282188No
365310951095.074.8274.8Root canal anatomy of the human permanent teeth. F J VertucciOral Surg Oral Med Oral Pathol19846595621Yes
365421891094.550.0825.0Hepatitis C virus infection. G M Lauer, B D WalkerN Engl J Med200111439948No
365510941094.00.00.0The stereotaxic method and radiosurgery of the brain. L LeksellActa Chir Scand195114914373Yes
365632811093.788.2529.4Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation. Davis J McCarthy, Yunshun Chen, Gordon K SmythNucleic Acids Res201222287627Yes
365721871093.5112.656.3The Neck Disability Index: a study of reliability and validity. H Vernon, S MiorJ Manipulative Physiol Ther19911834753Yes
365821871093.582.441.2Visual search and stimulus similarity. J Duncan, G W HumphreysPsychol Rev19892756067Yes
365921871093.545.7422.9The Hsp70 and Hsp60 chaperone machines. B Bukau, A L HorwichCell19989476895No
366010931093.028.6728.7Philosophical conceptions of the self: implications for cognitive science. I GallagherTrends Cogn Sci200010637618Yes
366110931093.00.00.0The purine and pyrimidine composition of deoxypentose nucleic acids. G R WyattBiochem J195114838906Yes
366210931093.029.8829.9Principles of c-di-GMP signalling in bacteria. Regine HenggeNat Rev Microbiol200919287449No
366321851092.577.4938.7Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. A I Basbaum, H L FieldsAnnu Rev Neurosci19846143527No
366421851092.561.1530.6ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control. Graham Noctor, Christine H. FoyerAnnu Rev Plant Physiol Plant Mol Biol199815012235Yes
366554621092.4114.7522.9The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. J W Harper, G R Adami, N Wei, K Keyomarsi, S J ElledgeCell19938242751Yes
366610921092.022.3922.4mRNA stability in mammalian cells. J RossMicrobiol Rev19957565413No
366710921092.033.8533.9The oxidation hypothesis of atherosclerosis. J L WitztumLancet19947916078No
366821841092.055.1327.6Antibacterial resistance worldwide: causes, challenges and responses. Stuart B Levy, Bonnie MarshallNat Med200415577930No
366921841092.053.2626.6Sulforhodamine B colorimetric assay for cytotoxicity screening. Vanicha Vichai, Kanyawim KirtikaraNat Protoc200617406391Yes
367010921092.031.4331.4Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Gregg L SemenzaTrends Pharmacol Sci201222398146No
367165511091.8168.1928.0The capsaicin receptor: a heat-activated ion channel in the pain pathway. M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D JuliusNature19979349813Yes
367232751091.768.7822.95-fluorouracil: mechanisms of action and clinical strategies. Daniel B Longley, D Paul Harkin, Patrick G JohnstonNat Rev Cancer200312724731No
367321831091.576.138.0Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. Hirenkumar K Makadia, Steven J SiegelPolymers (Basel)201122577513Yes
367410911091.025.3125.3Selectins and their ligands: current concepts and controversies. G S KansasBlood19968896391No
367510911091.027.6327.6Redefining oxidative stress. Dean P JonesAntioxid Redox Signal200616987039No
367632721090.7128.9843.0Concurrent and predictive validity of a self-reported measure of medication adherence. D E Morisky, L W Green, D M LevineMed Care19863945130Yes
367721811090.561.0230.5Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Amit Etkin, Tor D WagerAm J Psychiatry200717898336Yes
367854511090.2147.7929.6Biodiversity hotspots for conservation priorities. N Myers, R A Mittermeier, C G Mittermeier, G A da Fonseca, J KentNature200010706275Yes
367910901090.030.3130.3Transport of molecules in the tumor interstitium: a review. R K JainCancer Res19873555767No
368021801090.061.6930.8Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. Ivan Sondi, Branka Salopek-SondiJ Colloid Interface Sci200415158396Yes
368110901090.028.9629.0Neuronal gamma-band synchronization as a fundamental process in cortical computation. Pascal FriesAnnu Rev Neurosci200919400723No
368221791089.589.9445.0AKT/PKB Signaling: Navigating the Network. Brendan D Manning, Alex TokerCell201728431241No
368354471089.4164.1332.8Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. Salim Yusuf, Bertram Pitt, Clarence E Davis, William B Hood, Jay N CohnN Engl J Med19912057034Yes
368410891089.026.6526.6DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. J F WardProg Nucleic Acid Res Mol Biol19883065826No
368510891089.021.5321.5Coiled coils: new structures and new functions. A LupasTrends Biochem Sci19968918191No
368610891089.025.1825.2P-450 metabolites of arachidonic acid in the control of cardiovascular function. Richard J RomanPhysiol Rev200211773611No
368721781089.040.1120.1AP-1 as a regulator of cell life and death. Eitan Shaulian, Michael KarinNat Cell Biol200211988758No
368810891089.00.00.0The effect of emotion on cue utilization and the organization of behavior. J A EasterbrookPsychol Rev195913658305Yes
368910881088.039.3439.3Attention, similarity, and the identification-categorization relationship. R M NosofskyJ Exp Psychol Gen19862937873Yes
369010881088.023.8823.9New ideas about atrial fibrillation 50 years on. Stanley NattelNature200211805846No
369110881088.024.2824.3Liver regeneration. George K MichalopoulosJ Cell Physiol200717559071No
369210881088.00.00.0Aniline hydrogen phthalate as a spraying reagent for chromatography of sugars. S M PartridgeNature194918140444Yes
369310881088.033.4533.5Lanthanide luminescence for biomedical analyses and imaging. Jean-Claude G BünzliChem Rev201020151630No
369421751087.568.2634.1Glutamate and the pathophysiology of hypoxic--ischemic brain damage. S M Rothman, J W OlneyAnn Neurol19862421636No
369521751087.597.6948.8Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. J B Mulliken, J GlowackiPlast Reconstr Surg19827063565Yes
369665251087.5159.0726.5Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. S Yusuf, P Sleight, J Pogue, J Bosch, R Davies, G DagenaisN Engl J Med200010639539Yes
369710871087.019.7719.8Protein denaturation. C. Theoretical models for the mechanism of denaturation. C TanfordAdv Protein Chem19704912353No
369810871087.023.923.9The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion. S RosemanChem Phys Lipids19705476326Yes
369910871087.040.8540.9Beyond curriculum reform: confronting medicine's hidden curriculum. F W HaffertyAcad Med19989580717Yes
370010871087.069.969.9A network theory of mental disorders. Denny BorsboomWorld Psychiatry201728127906Yes
370121731086.5102.6451.3Problems and proposals for recording gingivitis and plaque. J Ainamo, I BayInt Dent J19751058834Yes
370221731086.590.245.1The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities. Samuel Genheden, Ulf RydeExpert Opin Drug Discov201525835573No
370310861086.064.8364.8The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture. J CasselAm J Epidemiol1976782233No
370410861086.037.3737.4Multiple organ failure. Pathophysiology and potential future therapy. E A DeitchAnn Surg19921503516No
370510861086.020.5720.6At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. M KozakJ Mol Biol19873681984Yes
370610861086.036.3636.4Lipid peroxidation and antioxidants as biomarkers of tissue damage. J M GutteridgeClin Chem19957497639No
370710861086.029.2329.2Interval estimation for the difference between independent proportions: comparison of eleven methods. R G NewcombeStat Med19989595617Yes
370810861086.028.7328.7Invited review: Aging and sarcopenia. Timothy J DohertyJ Appl Physiol (1985)200312970377No
370921721086.00.00.0A revision of the Schoenheimer-Sperry method for cholesterol determination. W M Sperry, M WebbJ Biol Chem195014794694Yes
371010861086.025.525.5Nitric oxide, oxidants, and protein tyrosine nitration. Rafael RadiProc Natl Acad Sci U S A200415020765Yes
371110861086.025.3525.4Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures. Frank WürthnerChem Commun (Camb)200415263926Yes
371210861086.020.7820.8mTOR and cancer: insights into a complex relationship. David M SabatiniNat Rev Cancer200616915295No
371310861086.024.924.9Structure and signalling in the IL-17 receptor family. Sarah L GaffenNat Rev Immunol200919575028No
371410851085.022.522.5T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. R H SchwartzAnnu Rev Immunol19852415139No
371510851085.022.5122.5Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. Z YangMol Biol Evol19989580986Yes
371610851085.023.8323.8Molecular mechanisms of myocardial remodeling. B SwynghedauwPhysiol Rev19999922372No
371710851085.010.7510.8Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. R M BerneAm J Physiol196313971060Yes
371810851085.032.9933.0On the mechanisms of biocompatibility. David F WilliamsBiomaterials200818440630No
371910851085.023.3523.4Serine/threonine phosphatases: mechanism through structure. Yigong ShiCell200919879837No
372021691084.550.9625.5Peroxidase-labeled antibody. A new method of conjugation. P K Nakane, A KawaoiJ Histochem Cytochem19744443551Yes
372110841084.018.7318.7Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. R RothsteinMethods Enzymol19912005793Yes
372210841084.045.1345.1Corticosteroids and lymphoid cells. H N ClamanN Engl J Med19725043524Yes
372310841084.016.2716.3The moulding of senescence by natural selection. W D HamiltonJ Theor Biol19666015424Yes
372410841084.036.1136.1Why we need observational studies to evaluate the effectiveness of health care. N BlackBMJ19968634569Yes
372510841084.032.9132.9Social cognition and the brain: a meta-analysis. Frank Van OverwalleHum Brain Mapp200918381770Yes
372643341083.5157.9739.5Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. K F Schulz, I Chalmers, R J Hayes, D G AltmanJAMA19957823387Yes
372721661083.065.0932.5A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. J J Sedmak, S E GrossbergAnal Biochem197768686Yes
372810831083.021.421.4Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution. Mats G L GustafssonProc Natl Acad Sci U S A200516141335Yes
372910831083.031.8431.8Phosphoinositides: tiny lipids with giant impact on cell regulation. Tamas BallaPhysiol Rev201323899561No
373021641082.047.1423.6Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. T Hunter, J PinesCell19947954824No
373132461082.079.7426.6METAL: fast and efficient meta-analysis of genomewide association scans. Cristen J Willer, Yun Li, Gonçalo R AbecasisBioinformatics201020616382Yes
373210811081.029.9830.0A teacher rating scale for use in drug studies with children. C K ConnersAm J Psychiatry19694900822Yes
373310811081.019.1719.2Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities. F FonnumBiochem J19694982085Yes
373421621081.044.1622.1The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. A Bairoch, R ApweilerNucleic Acids Res200010592178Yes
373510811081.027.4827.5Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Betsy FoxmanAm J Med200212113866No
373610811081.029.1429.1A perspective on judgment and choice: mapping bounded rationality. Daniel KahnemanAm Psychol200314584987No
373710801080.027.2927.3Avidin. N M GreenAdv Protein Chem1975237414Yes
373821601080.063.5131.8Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. J M Reul, E R de KloetEndocrinology19852998738Yes
373910801080.020.2120.2Progress in human tumour immunology and immunotherapy. S A RosenbergNature200111357146No
374032401080.063.1221.0Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Paola Scaffidi, Tom Misteli, Marco E BianchiNature200212110890Yes
374121601080.054.6427.3Anemia of chronic disease. Guenter Weiss, Lawrence T GoodnoughN Engl J Med200515758012No
374210801080.028.228.2Physiology and immunology of the cholinergic antiinflammatory pathway. Kevin J TraceyJ Clin Invest200717273548No
374321591079.586.9643.5Hearing lips and seeing voices. H McGurk, J MacDonaldNature19761012311Yes
374421591079.543.3421.7A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. C S Hoffman, F WinstonGene19873319781Yes
374521591079.545.0122.5Mitogen-activated protein kinase pathways. M J Robinson, M H CobbCurr Opin Cell Biol19979069255No
374621591079.599.8749.9Organic Photoredox Catalysis. Nathan A Romero, David A NicewiczChem Rev201627285582Yes
374710791079.041.3741.4A new international staging system for lung cancer. C F MountainChest19863514171No
374810791079.031.3731.4Why people use health services. I M RosenstockMilbank Mem Fund Q19665967464Yes
374910791079.027.0427.0Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. M J BerridgeBiochem J19836309155Yes
375010791079.028.5928.6Optogenetics. Karl DeisserothNat Methods201121191368Yes
375110791079.045.6845.7Bisphenol A and human health: a review of the literature. Johanna R RochesterReprod Toxicol201323994667No
375264691078.2138.9323.2Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. D A Melton, P A Krieg, M R Rebagliati, T Maniatis, K Zinn, M R GreenNucleic Acids Res19846091052Yes
375310781078.054.1854.2The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. J A KoufmanLaryngoscope19911895864No
375410781078.026.626.6The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. David S LudwigJAMA200211988062No
375510781078.018.2918.3Molecular mechanisms of axon guidance. Barry J DicksonScience200212471249No
375610781078.011.5211.5The Permeability Of Capillaries In Various Organs As Determined By Use Of The 'Indicator Diffusion' Method. C CroneActa Physiol Scand196314078649Yes
375710781078.030.3330.3The mechanisms of alloxan- and streptozotocin-induced diabetes. S LenzenDiabetologia200818087688No
375810781078.043.1743.2Likert scales, levels of measurement and the "laws" of statistics. Geoff NormanAdv Health Sci Educ Theory Pract201020146096Yes
375921561078.072.6136.3Photoacoustic tomography: in vivo imaging from organelles to organs. Lihong V Wang, Song HuScience201222442475No
376010781078.031.3831.4ERK1/2 MAP kinases: structure, function, and regulation. Robert RoskoskiPharmacol Res201222569528No
376121551077.570.2535.1Prostaglandins and inflammation. Emanuela Ricciotti, Garret A FitzGeraldArterioscler Thromb Vasc Biol201121508345No
376264641077.3179.0929.8Mild cognitive impairment: clinical characterization and outcome. R C Petersen, G E Smith, S C Waring, R J Ivnik, E G Tangalos, E KokmenArch Neurol199910190820Yes
376353861077.2196.5939.3A new clinical scale for the staging of dementia. C P Hughes, L Berg, W L Danziger, L A Coben, R L MartinBr J Psychiatry19827104545Yes
376421541077.091.9946.0Severe psoriasis--oral therapy with a new retinoid. T Fredriksson, U PetterssonDermatologica1978357213Yes
376510771077.018.1618.2Evolution and tinkering. F JacobScience1977860134Yes
376610771077.027.227.2Selectins: interpreters of cell-specific carbohydrate information during inflammation. L A LaskyScience19921439808No
376710771077.027.4627.5Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. J P TamProc Natl Acad Sci U S A19883399498Yes
376810771077.038.9238.9Relativistic electronic-structure calculations employing a two-component no-pair formalism with external-field projection operators. B A HessPhys Rev A Gen Phys19869897114Yes
376910771077.029.1129.1Ion suppression in mass spectrometry. Thomas M AnnesleyClin Chem200312816898No
377010761076.033.033.0Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. P StastnyN Engl J Med1978147420Yes
377110761076.030.6230.6Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. T FeiziNature19852579340Yes
377221521076.083.9342.0Glutathione reductase. I Carlberg, B MannervikMethods Enzymol19853003504Yes
377310761076.028.9629.0Statistical quality control and routine data processing for radioimmunoassays and immunoradiometric assays. D RodbardClin Chem19744370388No
377410761076.023.0723.1PHD: predicting one-dimensional protein structure by profile-based neural networks. B RostMethods Enzymol19968743704Yes
377521521076.087.2543.6Chronic catheterization of the spinal subarachnoid space. T L Yaksh, T A RudyPhysiol Behav197614677603Yes
377621511075.556.7628.4The evolution of cooperation. R Axelrod, W D HamiltonScience19817466396Yes
377710751075.028.628.6Autistic disturbances of affective contact. L KannerActa Paedopsychiatr19684880460Yes
377810751075.026.0526.1Looking into the functional architecture of the brain with diffusion MRI. Denis Le BihanNat Rev Neurosci200312778119No
377921501075.046.2223.1Modified reagents for determination of urea and ammonia. A L Chaney, E P MarbachClin Chem196213878063Yes
378010751075.033.5433.5Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. Jeffrey N KatzJ Bone Joint Surg Am200616595438No
378164501075.0173.5728.9Cancer statistics, 2007. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Taylor Murray, Jiaquan Xu, Michael J ThunCA Cancer J Clin200717237035Yes
378221491074.553.6326.8The regulation and function of c-fos and other immediate early genes in the nervous system. M Sheng, M E GreenbergNeuron19901969743No
378342971074.2102.1425.5The epidemiology of sepsis in the United States from 1979 through 2000. Greg S Martin, David M Mannino, Stephanie Eaton, Marc MossN Engl J Med200312700374Yes
378421481074.043.3921.7In search of the 'missing self': MHC molecules and NK cell recognition. H G Ljunggren, K KärreImmunol Today19902201309No
378510741074.045.3445.3Clinical experience with impedance audiometry. J JergerArch Otolaryngol19705455571Yes
378610741074.037.4537.5Coronary physiology. E O FeiglPhysiol Rev19836296890No
378710741074.033.3933.4Food reward: brain substrates of wanting and liking. K C BerridgeNeurosci Biobehav Rev19968622814No
378810741074.042.0742.1Gait changes in older adults: predictors of falls or indicators of fear. B E MakiJ Am Geriatr Soc19979063277Yes
378910741074.018.7718.8Regulatory T cells in autoimmmunity*. E M ShevachAnnu Rev Immunol200010837065No
379010741074.00.00.0The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs. M VogtJ Physiol195413152692Yes
379110741074.042.0542.0Intention-to-treat concept: A review. Sandeep K GuptaPerspect Clin Res201121897887Yes
379210741074.051.9151.9Using Bayes to get the most out of non-significant results. Zoltan DienesFront Psychol201425120503Yes
379310731073.042.2442.2Functional connections between cells as revealed by dye-coupling with a highly fluorescent naphthalimide tracer. W W StewartCell1978688392Yes
379421461073.069.3734.7Population growth makes waves in the distribution of pairwise genetic differences. A R Rogers, H HarpendingMol Biol Evol19921316531Yes
379510731073.024.2324.2The neurobiology of consolidations, or, how stable is the engram? Yadin DudaiAnnu Rev Psychol200414744210No
379653611072.2210.4742.1Salmon provides fast and bias-aware quantification of transcript expression. Rob Patro, Geet Duggal, Michael I Love, Rafael A Irizarry, Carl KingsfordNat Methods201728263959Yes
379710721072.030.9731.0Microbial heavy-metal resistance. D H NiesAppl Microbiol Biotechnol199910422221No
379810721072.034.9835.0Dual-processing accounts of reasoning, judgment, and social cognition. Jonathan St B T EvansAnnu Rev Psychol200818154502No
379910721072.027.2827.3Targeting cancer metabolism: a therapeutic window opens. Matthew G Vander HeidenNat Rev Drug Discov201121878982No
380032151071.7220.7573.6Sample Size in Qualitative Interview Studies: Guided by Information Power. Kirsti Malterud, Volkert Dirk Siersma, Ann Dorrit GuassoraQual Health Res201626613970Yes
380121431071.563.231.6Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. C N Hales, D J BarkerDiabetologia19921644236No
380242861071.5110.5827.6A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. I Vermes, C Haanen, H Steffens-Nakken, C ReutelingspergerJ Immunol Methods19957622868Yes
380321431071.537.618.8Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. W Gu, R G RoederCell19979288740Yes
380410711071.043.7343.7Movement, posture and equilibrium: interaction and coordination. J MassionProg Neurobiol19921736324No
380532131071.074.4324.8Marginal structural models and causal inference in epidemiology. J M Robins, M A Hernán, B BrumbackEpidemiology200010955408Yes
380610701070.035.1635.2Perceptual load as a necessary condition for selective attention. N LavieJ Exp Psychol Hum Percept Perform19957790827Yes
380710701070.029.1829.2Synchronization of cortical activity and its putative role in information processing and learning. W SingerAnnu Rev Physiol19938466179No
380810701070.023.3423.3ECM and cell surface proteolysis: regulating cellular ecology. Z WerbCell19979390552No
380910701070.025.5925.6Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. Mark E BoutonBiol Psychiatry200212437938No
381010701070.029.4329.4Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. John W NewcomerCNS Drugs200515998156No
381121401070.064.1532.1The memory function of sleep. Susanne Diekelmann, Jan BornNat Rev Neurosci201020046194No
381210701070.049.149.1Cystic fibrosis. J Stuart ElbornLancet201627140670No
381321391069.548.1324.1Effect of pegylation on pharmaceuticals. J Milton Harris, Robert B ChessNat Rev Drug Discov200312612647No
381410691069.030.6630.7Muscarinic receptors--characterization, coupling and function. M P CaulfieldPharmacol Ther19937504306No
381542761069.0109.7727.4Real time quantitative PCR. C A Heid, J Stevens, K J Livak, P M WilliamsGenome Res19968908518Yes
381610691069.026.3726.4Anti-inflammatory actions of glucocorticoids: molecular mechanisms. P J BarnesClin Sci (Lond)19989854452No
381710691069.028.5828.6Inhibition of return. R M KleinTrends Cogn Sci200010740278Yes
381810681068.029.5729.6Mitochondrial genetics: a paradigm for aging and degenerative diseases? D C WallaceScience19921533953Yes
381910681068.026.1726.2Biological effects of resveratrol. L FrémontLife Sci200010680575No
382042721068.0106.6426.7An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Joseph A Maldjian, Paul J Laurienti, Robert A Kraft, Jonathan H BurdetteNeuroimage200312880848Yes
382121361068.057.9129.0Targeting hypoxia in cancer therapy. William R Wilson, Michael P HayNat Rev Cancer201121606941No
382232041068.0116.838.9Stimuli-responsive nanocarriers for drug delivery. Simona Mura, Julien Nicolas, Patrick CouvreurNat Mater201324150417No
382364041067.3162.3527.1Ghrelin is a growth-hormone-releasing acylated peptide from stomach. M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K KangawaNature199910604470Yes
382410671067.00.00.0On the prediction of occurrence of particular verbal intrusions in immediate recall. J DeeseJ Exp Psychol195913664879Yes
382510671067.035.3435.3What Good Are Positive Emotions? Barbara L FredricksonRev Gen Psychol199821850154Yes
382610671067.031.6731.7Regulation of immune responses by prostaglandin E2. Pawel KalinskiJ Immunol201222187483No
382742671066.8217.754.4National Institute of Mental Health Diagnostic Interview Schedule. Its history, characteristics, and validity. L N Robins, J E Helzer, J Croughan, K S RatcliffArch Gen Psychiatry19816260053Yes
382853331066.6199.8740.0Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Jonathan D Power, Kelly A Barnes, Abraham Z Snyder, Bradley L Schlaggar, Steven E PetersenNeuroimage201222019881Yes
382921321066.038.0219.0Calcium-dependent bacteriophage DNA infection. M Mandel, A HigaJ Mol Biol19704922220Yes
383031981066.0166.5855.5Relatives of the impaired elderly: correlates of feelings of burden. S H Zarit, K E Reever, J Bach-PetersonGerontologist19807203086Yes
383110661066.018.9318.9Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. W KolchBiochem J200011023813No
383210661066.036.6536.6Stochastic thermodynamics, fluctuation theorems and molecular machines. Udo SeifertRep Prog Phys201223168354No
383321311065.569.0534.5Polymyositis and dermatomyositis (second of two parts). A Bohan, J B PeterN Engl J Med19751089199No
383421311065.539.2119.6Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. R Daniel Gietz, Robin A WoodsMethods Enzymol200212073338Yes
383521311065.561.7430.9Accurate molecular van der Waals interactions from ground-state electron density and free-atom reference data. Alexandre Tkatchenko, Matthias SchefflerPhys Rev Lett200919257665Yes
383621301065.060.030.0Binding of soluble form of fibroblast surface protein, fibronectin, to collagen. E Engvall, E RuoslahtiInt J Cancer1977903179Yes
383710651065.026.9727.0Axonal growth-associated proteins. J H SkeneAnnu Rev Neurosci19892648946No
383810651065.022.7722.8Ligand-targeted therapeutics in anticancer therapy. Theresa M AllenNat Rev Cancer200212360278No
383910651065.00.00.0Neural basis of the spontaneous optokinetic response produced by visual inversion. R W SperryJ Comp Physiol Psychol195014794830Yes
384010651065.032.0232.0Periodontitis: a polymicrobial disruption of host homeostasis. Richard P DarveauNat Rev Microbiol201020514045No
384121281064.079.8239.9A psychomotor stimulant theory of addiction. R A Wise, M A BozarthPsychol Rev19873317472No
384210641064.032.7832.8Prevention of drug access to bacterial targets: permeability barriers and active efflux. H NikaidoScience19948153625No
384310641064.032.3432.3Pectin structure and biosynthesis. Debra MohnenCurr Opin Plant Biol200818486536No
384421271063.574.3337.2The pathogenesis of atherosclerosis (first of two parts). R Ross, J A GlomsetN Engl J Med1976819830No
384521271063.561.2630.6Accurate and robust brain image alignment using boundary-based registration. Douglas N Greve, Bruce FischlNeuroimage200919573611Yes
384631901063.381.027.0Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions. M Piotto, V Saudek, V SklenárJ Biomol NMR19921490109Yes
384710631063.028.7828.8Microtubule formation in vitro in solutions containing low calcium concentrations. R C WeisenbergScience19724626639Yes
384810631063.029.5129.5Epidemiology of cancer of the colon and rectum. D P BurkittCancer19715165022Yes
384921261063.048.2224.1The significance of digital gene expression profiles. S Audic, J M ClaverieGenome Res19979331369Yes
385010631063.022.0222.0Oxidant signals and oxidative stress. Toren FinkelCurr Opin Cell Biol200312648682No
385110631063.025.6625.7Metagenomics: application of genomics to uncultured microorganisms. Jo HandelsmanMicrobiol Mol Biol Rev200415590779No
385210631063.030.9430.9Serine, glycine and one-carbon units: cancer metabolism in full circle. Jason W LocasaleNat Rev Cancer201323822983No
385310631063.053.7453.7Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress. Helmut SiesRedox Biol201728110218No
385421251062.587.6243.8Using Effect Size-or Why the P Value Is Not Enough. Gail M Sullivan, Richard FeinnJ Grad Med Educ201223997866Yes
385531871062.3149.0149.7Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. M Jondal, G Holm, H WigzellJ Exp Med19724114496Yes
385610621062.039.4839.5Infection by verocytotoxin-producing Escherichia coli. M A KarmaliClin Microbiol Rev19892644022No
385710621062.029.6529.6Transcranial magnetic stimulation: a primer. Mark HallettNeuron200717640522No
385821231061.50.00.0A microcolorimetric method for the determination of inorganic phosphorus. H H Taussky, E ShorrJ Biol Chem195313061491Yes
385921221061.0104.6552.3Optimism, coping, and health: assessment and implications of generalized outcome expectancies. M F Scheier, C S CarverHealth Psychol19854029106Yes
386010611061.029.2129.2Junctional intercellular communication: the cell-to-cell membrane channel. W R LoewensteinPhysiol Rev19816270711No
386121221061.045.1522.6InterProScan--an integration platform for the signature-recognition methods in InterPro. E M Zdobnov, R ApweilerBioinformatics200111590104Yes
386210611061.021.0921.1Automated NMR structure calculation with CYANA. Peter GüntertMethods Mol Biol200415318003Yes
386310611061.031.8631.9Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. Bruce S McEwenEur J Pharmacol200818282566No
386410601060.024.5724.6Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. S H KaufmannCancer Res19892790800Yes
386510601060.030.1430.1Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine. E M TanAdv Immunol19826182766No
386610601060.026.3426.3Skeletal complications of malignancy. R E ColemanCancer19979362426No
386710601060.023.1623.2Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Ferric C FangNat Rev Microbiol200415378046No
386810601060.00.00.0A Serological Differentiation Of Human And Other Groups Of Hemolytic Streptococci. R C LancefieldJ Exp Med193319870148Yes
386910601060.033.7333.7Isolation By Distance In Equilibrium And Non-Equilibrium Populations. Montgomery SlatkinEvolution199328568097Yes
387021191059.582.6741.3Comparative aspects of the brain growth spurt. J Dobbing, J SandsEarly Hum Dev1979118862Yes
387110591059.030.3230.3Pathogenetic mechanisms of septic shock. J E ParrilloN Engl J Med19938479467No
387221181059.039.9320.0Wnt signaling: a common theme in animal development. K M Cadigan, R NusseGenes Dev19979407023No
387310591059.030.3330.3Depression in the elderly. George S AlexopoulosLancet200515936426No
387410591059.025.0425.0Sjögren's syndrome. Robert I FoxLancet200516039337No
387531761058.776.1425.4Nitric oxide and macrophage function. J MacMicking, Q W Xie, C NathanAnnu Rev Immunol19979143691No
387621171058.50.00.0Use of glucose oxidase, peroxidase, and O-dianisidine in determination of blood and urinary glucose. A S Huggett, D A NixonLancet195713464070Yes
387710581058.036.8636.9A colorimetric method for estimating serum triglycerides. M J FletcherClin Chim Acta19685696963Yes
387810581058.024.5524.6Biochemistry and genetics of von Willebrand factor. J E SadlerAnnu Rev Biochem19989759493No
387910581058.023.3423.3Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. J Denis McGarryDiabetes200211756317No
388021161058.00.00.0Histochemistry of hepatic phosphatases of a physiologic pH; with special reference to the demonstration of bile canaliculi. M Wachstein, E MeiselAm J Clin Pathol195713410831Yes
388110581058.026.6726.7The potential environmental impact of engineered nanomaterials. Vicki L ColvinNat Biotechnol200314520401Yes
388210581058.030.5330.5Distracted and confused?: selective attention under load. Nilli LavieTrends Cogn Sci200515668100No
388310581058.00.00.0On the Absorption of Fluids from the Connective Tissue Spaces. E H StarlingJ Physiol189616992325Yes
388442311057.881.3720.3DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. M Okano, D W Bell, D A Haber, E LiCell199910555141Yes
388521151057.555.2327.6Sterile inflammation: sensing and reacting to damage. Grace Y Chen, Gabriel NuñezNat Rev Immunol201021088683No
388642291057.2144.4536.1Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. S Pellow, P Chopin, S E File, M BrileyJ Neurosci Methods19852864480Yes
388710571057.040.040.0The ovariectomized rat model of postmenopausal bone loss. D N KaluBone Miner19911773131No
388821141057.061.6730.8The biochemistry of P-glycoprotein-mediated multidrug resistance. J A Endicott, V LingAnnu Rev Biochem19892570548No
388910571057.029.7129.7Hepatitis B virus. The major etiology of hepatocellular carcinoma. R P BeasleyCancer19882834034No
389010571057.040.0740.1Electrolytes and interphases in Li-ion batteries and beyond. Kang XuChem Rev201425351820Yes
389121131056.554.0327.0Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. M S Brown, J L GoldsteinAnnu Rev Biochem19836311077No
389221131056.554.1627.1Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Donald E Owens, Nicholas A PeppasInt J Pharm200616303268No
389321131056.547.5223.8Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. Sharon R Browning, Brian L BrowningAm J Hum Genet200717924348Yes
389410561056.025.4525.4The ultrastructural basis of capillary permeability studied with peroxidase as a tracer. M J KarnovskyJ Cell Biol19676061717Yes
389510561056.021.1321.1The sequence manipulation suite: JavaScript programs for analyzing and formatting protein and DNA sequences. P StothardBiotechniques200010868275Yes
389610551055.023.8923.9The inducible transcription activator NF-kappa B: regulation by distinct protein subunits. P A BaeuerleBiochim Biophys Acta19912018779No
389710551055.021.5821.6The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells. D MetcalfNature19892469962No
389810551055.025.6125.6The granulocyte-macrophage colony-stimulating factors. D MetcalfScience19852990035No
389910551055.029.629.6Micellar nanocarriers: pharmaceutical perspectives. V P TorchilinPharm Res200717109211No
390031641054.766.2622.1TGF-beta signalling from cell membrane to nucleus through SMAD proteins. C H Heldin, K Miyazono, P ten DijkeNature19979393997No
390121091054.552.9526.5An improved general amino acid replacement matrix. Si Quang Le, Olivier GascuelMol Biol Evol200818367465Yes
390210541054.035.8935.9A theory of visual attention. C BundesenPsychol Rev19902247540Yes
390321081054.045.0222.5The immunoglobulin superfamily--domains for cell surface recognition. A F Williams, A N BarclayAnnu Rev Immunol19883289571No
390421081054.032.7916.4The growth of mouse bone marrow cells in vitro. T R Bradley, D MetcalfAust J Exp Biol Med Sci19664164182Yes
390510541054.029.729.7Determination of total protein. G L PetersonMethods Enzymol19836855607Yes
390610541054.043.2943.3Toward terminological, conceptual, and statistical clarity in the study of mediators and moderators: examples from the child-clinical and pediatric psychology literatures. G N HolmbeckJ Consult Clin Psychol19979256561Yes
390721081054.062.4931.2Extended-spectrum beta-lactamases: a clinical update. David L Paterson, Robert A BonomoClin Microbiol Rev200516223952No
390821071053.545.7822.9Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. P J Roberts, C J DerOncogene200717496923No
390931601053.360.7220.2Genetic instabilities in human cancers. C Lengauer, K W Kinzler, B VogelsteinNature19989872311No
391042131053.2114.0128.5Gene ontology analysis for RNA-seq: accounting for selection bias. Matthew D Young, Matthew J Wakefield, Gordon K Smyth, Alicia OshlackGenome Biol201020132535Yes
391110531053.024.3324.3Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. E M TanAdv Immunol19892646863No
391210531053.013.7413.7Relative and absolute strength of response as a function of frequency of reinforcement. R J HerrnsteinJ Exp Anal Behav196113713775Yes
391310531053.029.1529.1Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes. R BonnetAntimicrob Agents Chemother200414693512No
391410531053.031.631.6G(ST) and its relatives do not measure differentiation. Lou JostMol Ecol200819238703Yes
391510531053.036.3936.4The frailty syndrome: definition and natural history. Qian-Li XueClin Geriatr Med201121093718No
391621051052.580.9440.5Analysis of probability as an aid in the clinical diagnosis of coronary-artery disease. G A Diamond, J S ForresterN Engl J Med1979440357Yes
391721051052.558.4229.2The diversity and biogeography of soil bacterial communities. Noah Fierer, Robert B JacksonProc Natl Acad Sci U S A200616407148Yes
391873671052.4128.4718.4The human genome browser at UCSC. W James Kent, Charles W Sugnet, Terrence S Furey, Krishna M Roskin, Tom H Pringle, Alan M Zahler, David HausslerGenome Res200212045153Yes
391910521052.048.0948.1Carcinoid tumors. An analysis of 2,837 cases. J D GodwinCancer19751157019Yes
392021041052.042.0121.0IAP family proteins--suppressors of apoptosis. Q L Deveraux, J C ReedGenes Dev19999990849No

              Download as CSV


Copyright © 2020-2023 Solid Scientometrics Sp. z o.o.                                         Terms of Service                                                             Designed by Lukasz P. Kozlowski

All information that Unicorn Papers provides is based on PubMed data that are within the public domain. We acknowledge the NCBI, NLM, ORCID and iCite teams.