Unicorn Papers

Top ‱ cited papers from PUBMED

Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authors
Currently, the list contains 3816 papers with ECcit ≥ 1056.0
‱ - permyriad, , literally meaning "for (every) myriad (ten thousand)"

Volume 41, January 2024

No. Citations ECcit RCR ECRCR Title Authors Journal Year PMID Article(?)
1224539224539.05451.145451.1Cleavage of structural proteins during the assembly of the head of bacteriophage T4. U K LaemmliNature19705432063Yes
2171828171828.06755.36755.3A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. M M BradfordAnal Biochem1976942051Yes
328527271318.00.00.0Protein measurement with the Folin phenol reagent. O H Lowry, N J Rosebrough, A L Farr, R J RandallJ Biol Chem195114907713Yes
411944459722.02963.171481.6Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. K J Livak, T D SchmittgenMethods200111846609Yes
54513345133.01392.541392.5A short history of SHELX. George M SheldrickActa Crystallogr A200818156677Yes
63655336553.01176.931176.9Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. T MosmannJ Immunol Methods19836606682Yes
76434532172.51931.6965.8Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. P Chomczynski, N SacchiAnal Biochem19872440339Yes
83025830258.0821.37821.4Detection of specific sequences among DNA fragments separated by gel electrophoresis. E M SouthernJ Mol Biol19751195397Yes
92769127691.0900.98901.0The assessment and analysis of handedness: the Edinburgh inventory. R C OldfieldNeuropsychologia19715146491Yes
102759227592.0609.44609.4MicroRNAs: genomics, biogenesis, mechanism, and function. David P BartelCell200414744438No
112622626226.0620.81620.8MUSCLE: multiple sequence alignment with high accuracy and high throughput. Robert C EdgarNucleic Acids Res200415034147Yes
122573525735.0669.57669.6A rating scale for depression. M HamiltonJ Neurol Neurosurg Psychiatry196014399272Yes
132431324313.0557.49557.5A new mathematical model for relative quantification in real-time RT-PCR. M W PfafflNucleic Acids Res200111328886Yes
142424924249.0751.46751.5Confidence Limits On Phylogenies: An Approach Using The Bootstrap. Joseph FelsensteinEvolution198528561359Yes
156592821976.01647.7549.2DNA sequencing with chain-terminating inhibitors. F Sanger, S Nicklen, A R CoulsonProc Natl Acad Sci U S A1977271968Yes
166566021886.72499.48833.2"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. M F Folstein, S E Folstein, P R McHughJ Psychiatr Res19751202204Yes
174159520797.51309.5654.8Hallmarks of cancer: the next generation. Douglas Hanahan, Robert A WeinbergCell201121376230No
182064320643.0711.67711.7Density-functional exchange-energy approximation with correct asymptotic behavior. A D BeckePhys Rev A Gen Phys19889900728Yes
192025120251.0147.15147.2The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. E S ReynoldsJ Cell Biol196313986422Yes
203952419762.01219.34609.7The neighbor-joining method: a new method for reconstructing phylogenetic trees. N Saitou, M NeiMol Biol Evol19873447015Yes
211943719437.00.00.0Tissue sulfhydryl groups. G L EllmanArch Biochem Biophys195913650640Yes
223591817959.01699.3849.6Statistical methods for assessing agreement between two methods of clinical measurement. J M Bland, D G AltmanLancet19862868172Yes
231788617886.0501.36501.4Projector augmented-wave method. P E BlöchlPhys Rev B Condens Matter19949976227Yes
245352217840.71974.32658.1Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. H Towbin, T Staehelin, J GordonProc Natl Acad Sci U S A1979388439Yes
253485517427.51459.21729.6The measurement of observer agreement for categorical data. J R Landis, G G KochBiometrics1977843571Yes
261701217012.0622.72622.7A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. M KimuraJ Mol Evol19807463489Yes
271689016890.0424.33424.3Atherosclerosis--an inflammatory disease. R RossN Engl J Med19999887164No
281679516795.0636.46636.5Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. B J DavisAnn N Y Acad Sci196414240539Yes
291627916279.0706.06706.1RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Alexandros StamatakisBioinformatics201424451623Yes
301619316193.0447.67447.7High resolution two-dimensional electrophoresis of proteins. P H O'FarrellJ Biol Chem1975236308Yes
313213116065.50.00.0A rapid method of total lipid extraction and purification. E G Bligh, W J DyerCan J Biochem Physiol195913671378Yes
321594215942.00.00.0A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. K BurtonBiochem J195613293190Yes
331586115861.0652.52652.5A power primer. J CohenPsychol Bull199219565683Yes
341522815228.0385.1385.1MicroRNAs: target recognition and regulatory functions. David P BartelCell200919167326No
354518115060.31289.53429.8CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. J D Thompson, D G Higgins, T J GibsonNucleic Acids Res19947984417Yes
364483614945.31330.82443.6Generalized Gradient Approximation Made Simple. J P Perdew, K Burke, M ErnzerhofPhys Rev Lett199610062328Yes
372958614793.01184.67592.3The hospital anxiety and depression scale. A S Zigmond, R P SnaithActa Psychiatr Scand19836880820Yes
382936214681.01101.73550.9Meta-analysis in clinical trials. R DerSimonian, N LairdControl Clin Trials19863802833Yes
392888514442.5930.46465.2Fast gapped-read alignment with Bowtie 2. Ben Langmead, Steven L SalzbergNat Methods201222388286Yes
402848814244.0724.51362.3Fast and accurate short read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics200919451168Yes
411421814218.0554.04554.0Catalase in vitro. H AebiMethods Enzymol19846727660Yes
424151313837.70.00.0A simple method for the isolation and purification of total lipides from animal tissues. J Folch, M Lees, G H Sloane StanleyJ Biol Chem195713428781Yes
434042013473.31523.96508.0Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Michael I Love, Wolfgang Huber, Simon AndersGenome Biol201425516281Yes
441304213042.0687.46687.5Crystal structure refinement with SHELXL. George M SheldrickActa Crystallogr C Struct Chem201525567568Yes
451261212612.00.00.0Phosphorus assay in column chromatography. G R BartlettJ Biol Chem195913641241Yes
466218712437.41779.08355.8Basic local alignment search tool. S F Altschul, W Gish, W Miller, E W Myers, D J LipmanJ Mol Biol19902231712Yes
472450712253.5507.63253.8Coot: model-building tools for molecular graphics. Paul Emsley, Kevin CowtanActa Crystallogr D Biol Crystallogr200415572765Yes
483674512248.31302.95434.3Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. C Lee, W Yang, R G ParrPhys Rev B Condens Matter19889944570Yes
491219012190.0396.6396.6Search and clustering orders of magnitude faster than BLAST. Robert C EdgarBioinformatics201020709691Yes
502433312166.5998.92499.5The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. J E Ware, C D SherbourneMed Care19921593914Yes
512408912044.5527.92264.0Processing of X-ray diffraction data collected in oscillation mode. Z Otwinowski, W MinorMethods Enzymol199727754618Yes
521191011910.0307.77307.8Xds. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124692Yes
532372411862.0652.53326.3Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. G Kresse, J FurthmüllerPhys Rev B Condens Matter19969984901Yes
541177511775.0134.22134.2The genetics of Caenorhabditis elegans. S BrennerGenetics19744366476Yes
551162211622.0382.19382.2Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). J F KurtzkeNeurology19836685237Yes
561157411574.0349.88349.9The Psychophysics Toolbox. D H BrainardSpat Vis19979176952Yes
572308011540.0624.89312.4Quantifying heterogeneity in a meta-analysis. Julian P T Higgins, Simon G ThompsonStat Med200212111919Yes
581149011490.0537.93537.9Self-efficacy: toward a unifying theory of behavioral change. A BanduraPsychol Rev1977847061Yes
592158810794.0558.62279.3A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. A P Feinberg, B VogelsteinAnal Biochem19836312838Yes
601072910729.0410.39410.4A new method for measuring daytime sleepiness: the Epworth sleepiness scale. M W JohnsSleep19911798888Yes
612103310516.5460.8230.4[20] Processing of X-ray diffraction data collected in oscillation mode. Zbyszek Otwinowski, Wladek MinorMethods Enzymol199727799103Yes
621050910509.0365.6365.6Structure validation in chemical crystallography. Anthony L SpekActa Crystallogr D Biol Crystallogr200919171970Yes
631039010390.0365.08365.1Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Andreas StangEur J Epidemiol201020652370Yes
643105310351.01238.02412.7Trimmomatic: a flexible trimmer for Illumina sequence data. Anthony M Bolger, Marc Lohse, Bjoern UsadelBioinformatics201424695404Yes
651030710307.0202.69202.7Improvements in epoxy resin embedding methods. J H LuftJ Biophys Biochem Cytol196113764136Yes
663083310277.7802.05267.3VMD: visual molecular dynamics. W Humphrey, A Dalke, K SchultenJ Mol Graph19968744570Yes
671017610176.0415.0415.0Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Y KandaBone Marrow Transplant201323208313Yes
682030410152.0876.68438.3The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. R M Baron, D A KennyJ Pers Soc Psychol19863806354Yes
694049210123.01575.52393.9Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanPLoS Med200919621072No
704016310040.81150.39287.6Measuring inconsistency in meta-analyses. Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G AltmanBMJ200312958120No
71197919895.5402.09201.0The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. K Weber, M OsbornJ Biol Chem19695806584Yes
72296829894.01014.44338.1NIH Image to ImageJ: 25 years of image analysis. Caroline A Schneider, Wayne S Rasband, Kevin W EliceiriNat Methods201222930834No
73197709885.0769.75384.9MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Kazutaka Katoh, Daron M StandleyMol Biol Evol201323329690Yes
7497699769.00.00.0On the origin of cancer cells. O WarburgScience195613298683Yes
7596149614.0322.61322.6Banting lecture 1988. Role of insulin resistance in human disease. G M ReavenDiabetes19883056758No
7695399539.0268.49268.5Evolutionary trees from DNA sequences: a maximum likelihood approach. J FelsensteinJ Mol Evol19817288891Yes
77190039501.5409.95205.0KEGG: kyoto encyclopedia of genes and genomes. M Kanehisa, S GotoNucleic Acids Res200010592173Yes
78189129456.0487.7243.8A simple method for displaying the hydropathic character of a protein. J Kyte, R F DoolittleJ Mol Biol19827108955Yes
7994329432.0197.03197.0Mfold web server for nucleic acid folding and hybridization prediction. Michael ZukerNucleic Acids Res200312824337Yes
8093669366.0250.7250.7Semiempirical GGA-type density functional constructed with a long-range dispersion correction. Stefan GrimmeJ Comput Chem200616955487Yes
8193379337.0246.91246.9Studies on transformation of Escherichia coli with plasmids. D HanahanJ Mol Biol19836345791Yes
8292629262.0262.99263.0Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. P S ThomasProc Natl Acad Sci U S A19806159641Yes
8392429242.0398.26398.3Psychophysical bases of perceived exertion. G A BorgMed Sci Sports Exerc19827154893Yes
8492099209.0267.43267.4Vitamin D deficiency. Michael F HolickN Engl J Med200717634462No
8591919191.0239.06239.1RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. Alexandros StamatakisBioinformatics200616928733Yes
8691789178.0259.45259.4The pathogenesis of atherosclerosis: a perspective for the 1990s. R RossNature19938479518No
8790709070.0234.05234.1Integrins: versatility, modulation, and signaling in cell adhesion. R O HynesCell19921555235No
88181299064.5381.5190.8The hallmarks of cancer. D Hanahan, R A WeinbergCell200010647931No
8989838983.0266.14266.1The blockade of immune checkpoints in cancer immunotherapy. Drew M PardollNat Rev Cancer201222437870No
90357198929.81312.62328.2A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. M E Charlson, P Pompei, K L Ales, C R MacKenzieJ Chronic Dis19873558716Yes
9188218821.0407.77407.8Prokka: rapid prokaryotic genome annotation. Torsten SeemannBioinformatics201424642063Yes
9287978797.0178.45178.4Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Gordon K SmythStat Appl Genet Mol Biol200416646809Yes
93260828694.0672.92224.3Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Da Wei Huang, Brad T Sherman, Richard A LempickiNat Protoc200919131956Yes
94342768569.01106.49276.6Bias in meta-analysis detected by a simple, graphical test. M Egger, G Davey Smith, M Schneider, C MinderBMJ19979310563Yes
9585548554.0222.36222.4Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. M C HochbergArthritis Rheum19979324032Yes
96170968548.0452.37226.2Analyzing real-time PCR data by the comparative C(T) method. Thomas D Schmittgen, Kenneth J LivakNat Protoc200818546601Yes
9784858485.00.00.0Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. D I ArnonPlant Physiol194916654194Yes
9884748474.0180.0180.0The functions of animal microRNAs. Victor AmbrosNature200415372042No
99169438471.5373.26186.6Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Kazutoshi Takahashi, Shinya YamanakaCell200616904174Yes
10084098409.0203.93203.9PAML 4: phylogenetic analysis by maximum likelihood. Ziheng YangMol Biol Evol200717483113Yes
101503868397.73506.11584.4Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin JemalCA Cancer J Clin201830207593Yes
10283728372.0220.21220.2Canonical dynamics: Equilibrium phase-space distributions. W G HooverPhys Rev A Gen Phys19859895674Yes
10381108110.00.00.0The assessment of anxiety states by rating. M HamiltonBr J Med Psychol195913638508Yes
10480818081.0176.51176.5Solvent content of protein crystals. B W MatthewsJ Mol Biol19685700707Yes
10579977997.0210.32210.3Apoptosis: a review of programmed cell death. Susan ElmoreToxicol Pathol200717562483No
10679877987.0410.16410.2SHELXT - integrated space-group and crystal-structure determination. George M SheldrickActa Crystallogr A Found Adv201525537383Yes
107239077969.01374.67458.2MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Sudhir Kumar, Glen Stecher, Koichiro TamuraMol Biol Evol201627004904Yes
10879617961.0234.41234.4AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. R W CoxComput Biomed Res19968812068Yes
10979587958.0343.69343.7UPARSE: highly accurate OTU sequences from microbial amplicon reads. Robert C EdgarNat Methods201323955772Yes
11078667866.0217.57217.6"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. W N BurnetteAnal Biochem19816266278Yes
11178117811.0216.46216.5The role of protein kinase C in cell surface signal transduction and tumour promotion. Y NishizukaNature19846232463No
11277897789.0225.13225.1A simplification of the protein assay method of Lowry et al. which is more generally applicable. G L PetersonAnal Biochem1977603028Yes
113233277775.7626.31208.8edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Mark D Robinson, Davis J McCarthy, Gordon K SmythBioinformatics201019910308Yes
11477597759.0358.93358.9Comparative fit indexes in structural models. P M BentlerPsychol Bull19902320703Yes
115154607730.0377.76188.9MrBayes 3: Bayesian phylogenetic inference under mixed models. Fredrik Ronquist, John P HuelsenbeckBioinformatics200312912839Yes
11676537653.0205.53205.5Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. F TajimaGenetics19892513255Yes
11776537653.0156.5156.5Tumor angiogenesis: therapeutic implications. J FolkmanN Engl J Med19714938153No
11876447644.0226.54226.5Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. J R VaneNat New Biol19715284360Yes
11975847584.0251.99252.0Density-functional approximation for the correlation energy of the inhomogeneous electron gas. J P PerdewPhys Rev B Condens Matter19869938299Yes
12075757575.0204.07204.1Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. A BöyumScand J Clin Lab Invest Suppl19684179068Yes
121150927546.0338.52169.3Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. S J Clough, A F BentPlant J199810069079Yes
122224337477.7660.4220.1The PHQ-9: validity of a brief depression severity measure. K Kroenke, R L Spitzer, J B WilliamsJ Gen Intern Med200111556941Yes
12374687468.0160.18160.2Chromatin modifications and their function. Tony KouzaridesCell200717320507No
12474307430.0183.9183.9Fast robust automated brain extraction. Stephen M SmithHum Brain Mapp200212391568No
125222057401.7838.89279.6Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. W T Friedewald, R I Levy, D S FredricksonClin Chem19724337382Yes
12673567356.0134.4134.4A low-viscosity epoxy resin embedding medium for electron microscopy. A R SpurrJ Ultrastruct Res19694887011Yes
127511747310.61318.89188.4Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J LipmanNucleic Acids Res19979254694No
128143167158.0482.61241.3Three approaches to qualitative content analysis. Hsiu-Fang Hsieh, Sarah E ShannonQual Health Res200516204405Yes
129213427114.0649.64216.5Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Daniel Dindo, Nicolas Demartines, Pierre-Alain ClavienAnn Surg200415273542Yes
130142117105.5443.19221.6AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Oleg Trott, Arthur J OlsonJ Comput Chem201019499576Yes
13170487048.0213.08213.1The VideoToolbox software for visual psychophysics: transforming numbers into movies. D G PelliSpat Vis19979176953Yes
13270437043.0191.22191.2TreeView: an application to display phylogenetic trees on personal computers. R D PageComput Appl Biosci19968902363Yes
13370277027.0222.75222.8The Clinical Dementia Rating (CDR): current version and scoring rules. J C MorrisNeurology19938232972Yes
134138256912.5331.98166.0BEDTools: a flexible suite of utilities for comparing genomic features. Aaron R Quinlan, Ira M HallBioinformatics201020110278Yes
135138176908.5353.81176.9Continuous cultures of fused cells secreting antibody of predefined specificity. G Köhler, C MilsteinNature19751172191Yes
13668586858.0184.63184.6The steroid and thyroid hormone receptor superfamily. R M EvansScience19883283939No
13767616761.0237.37237.4The Strengths and Difficulties Questionnaire: a research note. R GoodmanJ Child Psychol Psychiatry19979255702Yes
138269296732.2885.76221.4G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel BuchnerBehav Res Methods200717695343Yes
13966966696.00.00.0The thiobarbituric acid assay of sialic acids. L WarrenJ Biol Chem195913672998Yes
14065766576.0172.32172.3Adhesion receptors of the immune system. T A SpringerNature19901974032No
141131146557.0309.31154.7Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Y Cheng, W H PrusoffBiochem Pharmacol19734202581Yes
142196126537.3549.0183.0A new generation of Ca2+ indicators with greatly improved fluorescence properties. G Grynkiewicz, M Poenie, R Y TsienJ Biol Chem19853838314Yes
14365336533.0213.24213.2Ethical guidelines for investigations of experimental pain in conscious animals. Manfred ZimmermannPain19836877845No
14465176517.0168.96169.0Angiogenesis in cancer, vascular, rheumatoid and other disease. J FolkmanNat Med19957584949No
145129286464.0699.25349.6Intraclass correlations: uses in assessing rater reliability. P E Shrout, J L FleissPsychol Bull197918839484No
14664586458.0128.43128.4Integrins: bidirectional, allosteric signaling machines. Richard O HynesCell200212297042No
147129146457.00.00.0Statistical aspects of the analysis of data from retrospective studies of disease. N Mantel, W HaenszelJ Natl Cancer Inst195913655060Yes
14863916391.0128.74128.7Rapid and efficient site-specific mutagenesis without phenotypic selection. T A KunkelProc Natl Acad Sci U S A19853881765Yes
14963576357.0168.74168.7A modified poisson regression approach to prospective studies with binary data. Guangyong ZouAm J Epidemiol200415033648Yes
15063426342.0135.74135.7p53, the cellular gatekeeper for growth and division. A J LevineCell19979039259No
15163096309.0149.22149.2Inflammation, atherosclerosis, and coronary artery disease. Göran K HanssonN Engl J Med200515843671No
152125256262.5347.51173.8EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Arnaud Delorme, Scott MakeigJ Neurosci Methods200415102499Yes
153125116255.5500.48250.2Prediction of creatinine clearance from serum creatinine. D W Cockcroft, M H GaultNephron19761244564Yes
15462446244.0111.5111.5A Self-Rating Depression Scale. W W ZungArch Gen Psychiatry196514221692Yes
155124286214.0426.09213.0The meaning and use of the area under a receiver operating characteristic (ROC) curve. J A Hanley, B J McNeilRadiology19827063747Yes
15661786178.0135.19135.2Inflammation in atherosclerosis. Peter LibbyNature200212490960No
15761496149.0144.07144.1Free radicals in the physiological control of cell function. Wulf DrögePhysiol Rev200211773609No
15861406140.0144.93144.9Biochemistry and molecular cell biology of diabetic complications. M BrownleeNature200111742414Yes
159122506125.0431.07215.5A rapid alkaline extraction procedure for screening recombinant plasmid DNA. H C Birnboim, J DolyNucleic Acids Res1979388356Yes
16061176117.0149.69149.7Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. T A SpringerCell19947507411No
16160666066.00.00.0Index for rating diagnostic tests. W J YoudenCancer195015405679Yes
162181316043.7894.16298.1Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. H Ohkawa, N Ohishi, K YagiAnal Biochem197936810Yes
16360396039.0152.35152.3Inositol trisphosphate and calcium signalling. M J BerridgeNature19938381210No
16460366036.0138.94138.9Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. J CastresanaMol Biol Evol200010742046Yes
16560256025.0153.0153.0G proteins: transducers of receptor-generated signals. A G GilmanAnnu Rev Biochem19873113327No
16660066006.0112.98113.0BLAT--the BLAST-like alignment tool. W James KentGenome Res200211932250Yes
167240056001.2767.25191.8Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. J M Chirgwin, A E Przybyla, R J MacDonald, W J RutterBiochemistry1979518835Yes
16859755975.0208.79208.8An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. Peter C AustinMultivariate Behav Res201121818162Yes
169119255962.5282.08141.0WGCNA: an R package for weighted correlation network analysis. Peter Langfelder, Steve HorvathBMC Bioinformatics200819114008Yes
17058935893.0142.86142.9Inflammation and metabolic disorders. Gökhan S HotamisligilNature200617167474No
171117805890.0285.83142.9MRBAYES: Bayesian inference of phylogenetic trees. J P Huelsenbeck, F RonquistBioinformatics200111524383Yes
17258535853.0135.44135.4Antimicrobial peptides of multicellular organisms. Michael ZasloffNature200211807545Yes
173115855792.5326.78163.4RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. Bo Li, Colin N DeweyBMC Bioinformatics201121816040Yes
174114985749.0265.07132.5Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. W Kabsch, C SanderBiopolymers19836667333Yes
17557415741.0171.34171.3Modification of seizure activity by electrical stimulation. II. Motor seizure. R J RacineElectroencephalogr Clin Neurophysiol19724110397Yes
17657245724.0143.08143.1Apoptosis in the pathogenesis and treatment of disease. C B ThompsonScience19957878464No
177114025701.0252.13126.1Dendritic cells and the control of immunity. J Banchereau, R M SteinmanNature19989521319No
178113795689.5434.26217.1The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. T Omura, R SatoJ Biol Chem196414209971Yes
179113385669.0248.34124.2One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. K A Datsenko, B L WannerProc Natl Acad Sci U S A200010829079Yes
180113245662.0308.98154.5Neuropathological stageing of Alzheimer-related changes. H Braak, E BraakActa Neuropathol19911759558No
18156495649.074.0974.1The Environment And Disease: Association Or Causation? A B HillProc R Soc Med196514283879Yes
182112035601.50.00.0A series of normal stages in the development of the chick embryo. V Hamburger, H L HamiltonJ Morphol195124539719Yes
183391175588.16816.35973.8Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie BrayCA Cancer J Clin202133538338Yes
18455595559.00.00.0Aging: a theory based on free radical and radiation chemistry. D HarmanJ Gerontol195613332224Yes
18555565556.0176.68176.7jModelTest: phylogenetic model averaging. David PosadaMol Biol Evol200818397919Yes
18655495549.0100.5100.5Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. F TietzeAnal Biochem19694388022Yes
18755255525.0155.08155.1A fast diffeomorphic image registration algorithm. John AshburnerNeuroimage200717761438Yes
188110455522.5289.86144.9Sequencing end-labeled DNA with base-specific chemical cleavages. A M Maxam, W GilbertMethods Enzymol19806246368Yes
18955215521.0133.17133.2Development of a rating scale for primary depressive illness. M HamiltonBr J Soc Clin Psychol19676080235Yes
19055115511.0119.93119.9The biochemistry of apoptosis. M O HengartnerNature200011048727No
19154915491.0122.05122.0MUSCLE: a multiple sequence alignment method with reduced time and space complexity. Robert C EdgarBMC Bioinformatics200415318951Yes
19254735473.0216.81216.8Orienting of attention. M I PosnerQ J Exp Psychol19807367577Yes
19354685468.0105.43105.4Evaluation of survival data and two new rank order statistics arising in its consideration. N MantelCancer Chemother Rep19665910392Yes
19454635463.095.8495.8Mutation and cancer: statistical study of retinoblastoma. A G KnudsonProc Natl Acad Sci U S A19715279523Yes
195109245462.0254.54127.3A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Stéphane Guindon, Olivier GascuelSyst Biol200314530136Yes
196163385446.0491.38163.8A simple salting out procedure for extracting DNA from human nucleated cells. S A Miller, D D Dykes, H F PoleskyNucleic Acids Res19883344216Yes
197108765438.0288.91144.5Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. Florian Weigend, Reinhart AhlrichsPhys Chem Chem Phys200516240044Yes
19853575357.0138.44138.4The Cambridge Structural Database: a quarter of a million crystal structures and rising. Frank H AllenActa Crystallogr B200212037359Yes
199106995349.5299.06149.5MODELTEST: testing the model of DNA substitution. D Posada, K A CrandallBioinformatics19989918953Yes
200106885344.0227.23113.6Inflammation and cancer. Lisa M Coussens, Zena WerbNature200212490959No
201106775338.5750.38375.2A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. Terry K Koo, Mae Y LiJ Chiropr Med201627330520Yes
20253125312.0135.07135.1New M13 vectors for cloning. J MessingMethods Enzymol19836310323Yes
20352925292.0156.77156.8Developments of a water-maze procedure for studying spatial learning in the rat. R MorrisJ Neurosci Methods19846471907Yes
20452925292.0127.7127.7The NF-kappa B and I kappa B proteins: new discoveries and insights. A S BaldwinAnnu Rev Immunol19968717528No
205105645282.01034.38517.2Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. Zunyou Wu, Jennifer M McGooganJAMA202032091533Yes
20652805280.0152.61152.6Studies and perspectives of protein kinase C. Y NishizukaScience19863014651No
207263965279.2712.08142.4The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G HigginsNucleic Acids Res19979396791Yes
208157805260.0560.29186.8Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Allison Tong, Peter Sainsbury, Jonathan CraigInt J Qual Health Care200717872937Yes
209104785239.0271.12135.6Differential expression analysis for sequence count data. Simon Anders, Wolfgang HuberGenome Biol201020979621Yes
21052355235.0102.36102.4Epithelial-mesenchymal transitions in tumour progression. Jean Paul ThieryNat Rev Cancer200212189386No
21152215221.00.00.0[A micro-method of immuno-electrophoresis]. J J ScheideggerInt Arch Allergy Appl Immunol195513262900Yes
212104375218.5345.7172.8Operating characteristics of a rank correlation test for publication bias. C B Begg, M MazumdarBiometrics19947786990Yes
213104255212.50.00.0A quantitative description of membrane current and its application to conduction and excitation in nerve. A L Hodgkin, A F HuxleyJ Physiol195212991237Yes
21452115211.0189.03189.0Oxygen-derived free radicals in postischemic tissue injury. J M McCordN Engl J Med19852981404No
21552035203.0172.72172.7Whatever happened to qualitative description? M SandelowskiRes Nurs Health200010940958No
21651895189.066.0966.1Selective extraction of polyoma DNA from infected mouse cell cultures. B HirtJ Mol Biol19674291934Yes
217155375179.0584.35194.8The positive and negative syndrome scale (PANSS) for schizophrenia. S R Kay, A Fiszbein, L A OplerSchizophr Bull19873616518Yes
218103555177.5482.73241.4A new depression scale designed to be sensitive to change. S A Montgomery, M AsbergBr J Psychiatry1979444788Yes
21951635163.0136.64136.6Mild cognitive impairment as a diagnostic entity. R C PetersenJ Intern Med200415324362No
220103075153.5365.25182.6The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. R F Furchgott, J V ZawadzkiNature19806253831Yes
22151395139.052.8752.9The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. P LaurenActa Pathol Microbiol Scand196514320675Yes
22251175117.0187.42187.4Analyzing Tables Of Statistical Tests. William R RiceEvolution198928568501Yes
223102145107.0271.53135.8Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. H Schägger, G von JagowAnal Biochem19872449095Yes
22451025102.0157.08157.1Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. Ilan H MeyerPsychol Bull200312956539No
22550995099.0101.75101.8Rho GTPases and the actin cytoskeleton. A HallScience19989438836No
22650825082.0139.79139.8How mitochondria produce reactive oxygen species. Michael P MurphyBiochem J200919061483No
22750795079.0124.16124.2Emotion circuits in the brain. J E LeDouxAnnu Rev Neurosci200010845062No
228152245074.7375.7125.2Inference of population structure using multilocus genotype data. J K Pritchard, M Stephens, P DonnellyGenetics200010835412Yes
229101225061.0241.04120.5Comparative protein modelling by satisfaction of spatial restraints. A Sali, T L BlundellJ Mol Biol19938254673Yes
23050375037.0192.21192.2Revisiting the behavioral model and access to medical care: does it matter? R M AndersenJ Health Soc Behav19957738325Yes
231100645032.0218.91109.5The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. John Hardy, Dennis J SelkoeScience200212130773No
23250265026.0228.73228.7Interrater reliability: the kappa statistic. Mary L McHughBiochem Med (Zagreb)201223092060Yes
23350175017.0101.48101.5Targeting HIF-1 for cancer therapy. Gregg L SemenzaNat Rev Cancer200313130303No
23499814990.5220.38110.2MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Jürgen Cox, Matthias MannNat Biotechnol200819029910Yes
235149444981.3538.39179.5Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. S M Hsu, L Raine, H FangerJ Histochem Cytochem19816166661Yes
23649594959.0143.67143.7A protein binding assay for adenosine 3':5'-cyclic monophosphate. A G GilmanProc Natl Acad Sci U S A19704318781Yes
23749224922.0140.66140.7Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. C B LaurellAnal Biochem19665959431Yes
238245964919.21087.86217.6MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir KumarMol Biol Evol201324132122Yes
23998064903.0350.12175.1Ligand: a versatile computerized approach for characterization of ligand-binding systems. P J Munson, D RodbardAnal Biochem19806254391Yes
24049004900.0191.74191.7The need for a new medical model: a challenge for biomedicine. G L EngelScience1977847460Yes
24148974897.0110.9110.9Tandem repeats finder: a program to analyze DNA sequences. G BensonNucleic Acids Res19999862982Yes
24297914895.5233.77116.9A genetic model for colorectal tumorigenesis. E R Fearon, B VogelsteinCell19902188735No
243146024867.3391.76130.6Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. C Yanisch-Perron, J Vieira, J MessingGene19852985470Yes
24448674867.0110.13110.1The clonal evolution of tumor cell populations. P C NowellScience1976959840Yes
24548484848.097.8697.9An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. M KozakNucleic Acids Res19873313277No
246144864828.71097.23365.7Cancer statistics, 2019. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201930620402Yes
247144694823.0357.35119.1A comprehensive set of sequence analysis programs for the VAX. J Devereux, P Haeberli, O SmithiesNucleic Acids Res19846546423Yes
24847854785.089.9489.9DNA methylation patterns and epigenetic memory. Adrian BirdGenes Dev200211782440No
249143394779.70.00.0Determination of serum proteins by means of the biuret reaction. A G Gornall, C J Bardawill, M M DavidJ Biol Chem194918110453Yes
250191084777.0494.1123.5Features and development of Coot. P Emsley, B Lohkamp, W G Scott, K CowtanActa Crystallogr D Biol Crystallogr201020383002Yes
25147724772.0128.53128.5Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. M RodbellJ Biol Chem196414169133Yes
252238514770.2407.5481.5An inventory for measuring depression. A T Beck, C H Ward, M Mendelson, J Mock, J ErbaughArch Gen Psychiatry196113688369Yes
25347584758.0104.3104.3Cancer cell cycles. C J SherrScience19968939849No
25495094754.5159.3179.7A new technique for the assay of infectivity of human adenovirus 5 DNA. F L Graham, A J van der EbVirology19734705382Yes
25547474747.0106.42106.4ras oncogenes in human cancer: a review. J L BosCancer Res19892547513No
25647364736.0157.12157.1Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. W H HarrisJ Bone Joint Surg Am19695783851Yes
25794724736.0256.85128.4The rise of graphene. A K Geim, K S NovoselovNat Mater200717330084Yes
25894054702.5237.45118.7Improved tools for biological sequence comparison. W R Pearson, D J LipmanProc Natl Acad Sci U S A19883162770Yes
25947024702.0157.03157.0The pathogenesis of atherosclerosis--an update. R RossN Engl J Med19863511384No
26047024702.0222.5222.5Executive functions. Adele DiamondAnnu Rev Psychol201323020641No
26193514675.5208.83104.4Parkinsonism: onset, progression and mortality. M M Hoehn, M D YahrNeurology19676067254Yes
26246704670.0103.05103.0Alzheimer's disease: genes, proteins, and therapy. D J SelkoePhysiol Rev200111274343No
26346684668.0129.87129.9Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. P MatsudairaJ Biol Chem19873611052Yes
26446634663.0215.3215.3The McGill Pain Questionnaire: major properties and scoring methods. Ronald MelzackPain19751235985Yes
26546624662.072.2772.3Aggregation of blood platelets by adenosine diphosphate and its reversal. G V BornNature196213871375Yes
266139524650.7305.33101.8Refinement of macromolecular structures by the maximum-likelihood method. G N Murshudov, A A Vagin, E J DodsonActa Crystallogr D Biol Crystallogr199715299926Yes
26746434643.0125.39125.4A rapid banding technique for human chromosomes. M SeabrightLancet19714107917Yes
268278584643.0982.75163.8Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G CondeJ Biomed Inform200918929686Yes
269139224640.71381.78460.6Cancer statistics, 2020. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin202031912902Yes
270139074635.7480.0160.0Nitric oxide: physiology, pathophysiology, and pharmacology. S Moncada, R M Palmer, E A HiggsPharmacol Rev19911852778No
271185284632.0535.03133.8MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir KumarMol Biol Evol200717488738Yes
27246044604.0102.27102.3Prions. S B PrusinerProc Natl Acad Sci U S A19989811807No
273183354583.8296.3474.1A new and rapid colorimetric determination of acetylcholinesterase activity. G L Ellman, K D Courtney, V Andres, R M Feather-StoneBiochem Pharmacol196113726518Yes
27445834583.040.340.3The Limited In Vitro Lifetime Of Human Diploid Cell Strains. L HayflickExp Cell Res196514315085Yes
27591564578.0182.3891.2Assessment of older people: self-maintaining and instrumental activities of daily living. M P Lawton, E M BrodyGerontologist19695349366Yes
27690914545.5249.48124.7Ab initio molecular dynamics for liquid metals. G Kresse, J HafnerPhys Rev B Condens Matter199310004490Yes
27790554527.5310.24155.1Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. U H Graneheim, B LundmanNurse Educ Today200414769454No
27845254525.098.0198.0ras genes. M BarbacidAnnu Rev Biochem19873304147No
27990484524.0330.99165.5Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Kristopher J Preacher, Andrew F HayesBehav Res Methods200818697684Yes
28045244524.0226.87226.9Minimap2: pairwise alignment for nucleotide sequences. Heng LiBioinformatics201829750242Yes
28190364518.0149.8774.9Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J M McCord, I FridovichJ Biol Chem19695389100Yes
28245164516.0106.2106.2The genetical evolution of social behaviour. I. W D HamiltonJ Theor Biol19645875341Yes
28390324516.0200.96100.5Primer3 on the WWW for general users and for biologist programmers. S Rozen, H SkaletskyMethods Mol Biol200010547847Yes
28445134513.093.2393.2Alternative activation of macrophages. Siamon GordonNat Rev Immunol200312511873No
28544974497.0140.77140.8Updating P300: an integrative theory of P3a and P3b. John PolichClin Neurophysiol200717573239No
28689474473.5148.2674.1Functional Evaluation: The Barthel Index. F I Mahoney, D W BarthelMd State Med J196514258950Yes
28789224461.00.00.0A simplified method of evaluating dose-effect experiments. J T Litchfield, F WilcoxonJ Pharmacol Exp Ther194918152921Yes
28844544454.090.1490.1Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. M KozakCell19863943125Yes
28944464446.0102.74102.7Cancer. p53, guardian of the genome. D P LaneNature19921614522No
29044464446.0107.75107.8A new method for predicting signal sequence cleavage sites. G von HeijneNucleic Acids Res19863714490Yes
291133044434.7528.71176.2A global measure of perceived stress. S Cohen, T Kamarck, R MermelsteinJ Health Soc Behav19836668417Yes
292133024434.0586.08195.4Development and validation of brief measures of positive and negative affect: the PANAS scales. D Watson, L A Clark, A TellegenJ Pers Soc Psychol19883397865Yes
293266034433.8930.36155.1Global cancer statistics. Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David FormanCA Cancer J Clin201121296855Yes
29444324432.0165.69165.7FreeSurfer. Bruce FischlNeuroimage201222248573No
29588394419.5236.91118.5A synaptic model of memory: long-term potentiation in the hippocampus. T V Bliss, G L CollingridgeNature19938421494No
29688304415.0211.44105.7Collective dynamics of 'small-world' networks. D J Watts, S H StrogatzNature19989623998Yes
29787824391.0161.0780.5A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. W M Bonner, R A LaskeyEur J Biochem19744850204Yes
29887714385.5221.62110.8Assessment of coma and impaired consciousness. A practical scale. G Teasdale, B JennettLancet19744136544Yes
29987454372.5202.13101.1SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. N Guex, M C PeitschElectrophoresis19979504803Yes
30043654365.090.1290.1Wnt/beta-catenin signaling in development and disease. Hans CleversCell200617081971No
30143594359.083.4683.5The phosphoinositide 3-kinase pathway. Lewis C CantleyScience200212040186No
30243554355.0218.8218.8Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. M M MesulamJ Histochem Cytochem197824068Yes
30343514351.0112.22112.2Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Y NishizukaScience19921411571No
30443504350.0103.59103.6Why most published research findings are false. John P A IoannidisPLoS Med200516060722Yes
305259134318.8959.65159.9MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir KumarMol Biol Evol201121546353Yes
306129504316.7653.89218.0Cancer statistics, 2016. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201626742998Yes
30743154315.0101.19101.2Mechanisms of angiogenesis. W RisauNature19979109485No
30843034303.0128.87128.9Glutamate neurotoxicity and diseases of the nervous system. D W ChoiNeuron19882908446No
30986064303.0116.7258.4Preparation of iodine-131 labelled human growth hormone of high specific activity. W M Hunter, F C GreenwoodNature196214450081Yes
31086044302.0232.28116.1Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii. Daniel E Voth, Robert A HeinzenCell Microbiol200717381428No
31142824282.093.1193.1Apoptosis by death factor. S NagataCell19979039262No
31242814281.0113.64113.6The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Y NishizukaNature19883045562No
31342584258.0110.49110.5Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. A H WyllieNature19806245367Yes
31442584258.0155.18155.2EuroQol: the current state of play. R BrooksHealth Policy199610158943No
31542494249.080.1580.2The detection of disease clustering and a generalized regression approach. N MantelCancer Res19676018555Yes
31642424242.00.00.0Evolution in Mendelian Populations. S WrightGenetics193117246615Yes
31742374237.00.00.0Estimation of nuclear population from microtome sections. M AbercrombieAnat Rec194621015608Yes
31842344234.00.00.0The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. T NashBiochem J195313105648Yes
31942284228.00.00.0Amino acid metabolism in mammalian cell cultures. H EagleScience195913675766Yes
32042204220.087.4387.4The retinoblastoma protein and cell cycle control. R A WeinbergCell19957736585No
32142174217.093.893.8Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. S HenikoffGene19846235151Yes
32242174217.00.00.0New methods for calculating metabolic rate with special reference to protein metabolism. J B De B WeirJ Physiol194915394301Yes
32384204210.0243.6121.8Estimating F-Statistics For The Analysis Of Population Structure. B S Weir, C Clark CockerhamEvolution198428563791Yes
324126244208.0405.31135.1Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. E R DeLong, D M DeLong, D L Clarke-PearsonBiometrics19883203132Yes
325126214207.0789.21263.1Cancer statistics, 2018. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201829313949Yes
32642004200.00.00.0A relation between non-esterified fatty acids in plasma and the metabolism of glucose. V P DoleJ Clin Invest195613286333Yes
32783894194.5310.67155.3The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. I F Benzie, J J StrainAnal Biochem19968660627Yes
32883784189.0347.04173.5The timed "Up & Go": a test of basic functional mobility for frail elderly persons. D Podsiadlo, S RichardsonJ Am Geriatr Soc19911991946Yes
32941814181.075.6875.7Generalized lacZ expression with the ROSA26 Cre reporter strain. P SorianoNat Genet19999916792Yes
33041804180.090.9791.0Atherosclerosis. A J LusisNature200011001066No
331125384179.3463.32154.4HTSeq--a Python framework to work with high-throughput sequencing data. Simon Anders, Paul Theodor Pyl, Wolfgang HuberBioinformatics201525260700Yes
33241794179.087.1387.1Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. C J MarshallCell19957834738No
33341554155.0155.97156.0Measuring the accuracy of diagnostic systems. J A SwetsScience19883287615No
334249304155.0813.45135.6Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C TurnerDiabetologia19853899825Yes
33541554155.088.8588.8Protein production by auto-induction in high density shaking cultures. F William StudierProtein Expr Purif200515915565Yes
33641524152.050.4650.5Bone: formation by autoinduction. M R UristScience19655319761Yes
33783024151.00.00.0Radiological assessment of osteo-arthrosis. J H Kellgren, J S LawrenceAnn Rheum Dis195713498604Yes
33882924146.0347.69173.8phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. Paul J McMurdie, Susan HolmesPLoS One201323630581Yes
33941434143.0166.9166.9Determination of protein: a modification of the Lowry method that gives a linear photometric response. E F HartreeAnal Biochem19724115981Yes
34082794139.5177.5588.8Genomic sequencing. G M Church, W GilbertProc Natl Acad Sci U S A19846326095Yes
34141364136.00.00.0The determination of enzyme inhibitor constants. M DixonBiochem J195313093635Yes
342123684122.7552.1184.0Deep learning. Yann LeCun, Yoshua Bengio, Geoffrey HintonNature201526017442No
34341174117.091.4491.4PAML: a program package for phylogenetic analysis by maximum likelihood. Z YangComput Appl Biosci19979367129Yes
34441154115.0107.52107.5Staphylococcus aureus infections. F D LowyN Engl J Med19989709046No
34540944094.0110.59110.6Mesenchymal stem cells. A I CaplanJ Orthop Res19911870029Yes
34640824082.0127.73127.7Bacterial evolution. C R WoeseMicrobiol Rev19872439888No
347122414080.3453.33151.1A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. J Ware, M Kosinski, S D KellerMed Care19968628042Yes
348162074051.8518.55129.6A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge KriegJ Chem Phys201020423165Yes
34980954047.5209.82104.9Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. D E Paglia, W N ValentineJ Lab Clin Med19676066618Yes
350161804045.0611.26152.8Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanAnn Intern Med200919622511No
35180814040.5259.92130.0DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. P Librado, J RozasBioinformatics200919346325Yes
35240364036.083.9483.9The green fluorescent protein. R Y TsienAnnu Rev Biochem19989759496No
353281874026.7623.2489.0UCSF Chimera--a visualization system for exploratory research and analysis. Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E FerrinJ Comput Chem200415264254Yes
35440264026.0175.69175.7A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. E PfeifferJ Am Geriatr Soc19751159263Yes
35540164016.0103.64103.6Integrins: a family of cell surface receptors. R O HynesCell19873028640No
356120164005.3650.79216.9Cancer Statistics, 2017. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201728055103Yes
35739973997.0101.52101.5The Scree Test For The Number Of Factors. R B CattellMultivariate Behav Res196626828106Yes
35879653982.5203.64101.8tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. T M Lowe, S R EddyNucleic Acids Res19979023104Yes
35939823982.0106.82106.8What is the evidence that tumors are angiogenesis dependent? J FolkmanJ Natl Cancer Inst19901688381No
36039803980.078.5678.6Hypoxia--a key regulatory factor in tumour growth. Adrian L HarrisNat Rev Cancer200211902584No
36139783978.0128.18128.2Tissue destruction by neutrophils. S J WeissN Engl J Med19892536474No
36239683968.00.00.0Staining of tissue sections for electron microscopy with heavy metals. M L WatsonJ Biophys Biochem Cytol195813563554Yes
36339643964.0115.68115.7Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. D VanderbiltPhys Rev B Condens Matter19909993096Yes
36439563956.0125.96126.0How do you feel--now? The anterior insula and human awareness. A D Bud CraigNat Rev Neurosci200919096369No
36539543954.070.0470.0Principles that govern the folding of protein chains. C B AnfinsenScience19734124164Yes
36639523952.0146.3146.3A concordance correlation coefficient to evaluate reproducibility. L I LinBiometrics19892720055Yes
36739493949.0129.52129.5Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. J CohenPsychol Bull196819673146Yes
368157393934.8578.22144.6Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanBMJ200919622551No
36939343934.0144.04144.0Disc Electrophoresis. I. Background And Theory. L OrnsteinAnn N Y Acad Sci196414240533Yes
37078653932.5148.0474.0A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. R S Sikorski, P HieterGenetics19892659436Yes
37178543927.0212.29106.1Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. H Aviv, P LederProc Natl Acad Sci U S A19724504350Yes
37239263926.096.796.7Multiple sequence alignment with hierarchical clustering. F CorpetNucleic Acids Res19882849754Yes
37339223922.0122.36122.4Emerging adulthood. A theory of development from the late teens through the twenties. J J ArnettAm Psychol200010842426Yes
37439013901.0120.26120.3Nitric oxide as a secretory product of mammalian cells. C NathanFASEB J19921381691No
37577843892.0293.85146.9Multiwfn: a multifunctional wavefunction analyzer. Tian Lu, Feiwu ChenJ Comput Chem201222162017Yes
376116723890.7304.58101.5Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. J F Kerr, A H Wyllie, A R CurrieBr J Cancer19724561027No
377116703890.0298.5799.5Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. W H Habig, M J Pabst, W B JakobyJ Biol Chem19744436300Yes
37838833883.098.5298.5Oxidative stress, antioxidants and stress tolerance. Ron MittlerTrends Plant Sci200212234732No
37977583879.0197.4698.7Control of goal-directed and stimulus-driven attention in the brain. Maurizio Corbetta, Gordon L ShulmanNat Rev Neurosci200211994752No
38038723872.0119.13119.1Pharmacological implications of microsomal enzyme induction. A H ConneyPharmacol Rev19674383307Yes
38138723872.080.1980.2Protein secondary structure prediction based on position-specific scoring matrices. D T JonesJ Mol Biol199910493868Yes
38238703870.0125.27125.3Preparation of isolated rat liver cells. P O SeglenMethods Cell Biol1976177845No
38338613861.083.883.8Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Rakesh K JainScience200515637262No
38477213860.5215.1107.5Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. S Duval, R TweedieBiometrics200010877304Yes
38538513851.0185.99186.0Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Daniël LakensFront Psychol201324324449No
38638503850.0127.99128.0Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Russell A BarkleyPsychol Bull19979000892No
38738483848.0102.66102.7Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. R B D'AgostinoStat Med19989802183Yes
38838383838.0101.88101.9Observational study of behavior: sampling methods. J AltmannBehaviour19744597405No
38976563828.0144.5972.3Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. A H Brand, N PerrimonDevelopment19938223268Yes
39038183818.090.9791.0Caspases: the executioners of apoptosis. G M CohenBiochem J19979337844No
39138183818.083.783.7Folding DNA to create nanoscale shapes and patterns. Paul W K RothemundNature200616541064Yes
392343343814.9874.8497.2The Sequence Alignment/Map format and SAMtools. Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard DurbinBioinformatics200919505943Yes
39338083808.0102.74102.7Revisions in the International System for Staging Lung Cancer. C F MountainChest19979187198Yes
394152253806.2461.85115.5clusterProfiler: an R package for comparing biological themes among gene clusters. Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu HeOMICS201222455463Yes
395114123804.0381.54127.2featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Yang Liao, Gordon K Smyth, Wei ShiBioinformatics201424227677Yes
39637953795.097.9497.9Sequencing technologies - the next generation. Michael L MetzkerNat Rev Genet201019997069No
39737913791.080.1280.1A catalogue of splice junction sequences. S M MountNucleic Acids Res19827063411Yes
39837843784.096.9496.9Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Kim A BrogdenNat Rev Microbiol200515703760No
39937773777.084.1684.2Instability and decay of the primary structure of DNA. T LindahlNature19938469282No
40075523776.0182.4891.2Mitochondria and apoptosis. D R Green, J C ReedScience19989721092No
40137733773.073.8473.8Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. G R MartinProc Natl Acad Sci U S A19816950406Yes
40237723772.077.677.6TGF-beta signal transduction. J MassaguéAnnu Rev Biochem19989759503No
40337613761.0146.54146.5Estimation of the molecular weights of proteins by Sephadex gel-filtration. P AndrewsBiochem J19644158310Yes
40437543754.0107.21107.2Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. J H MorrisseyAnal Biochem19816172996Yes
40537543754.094.494.4The origins and the future of microfluidics. George M WhitesidesNature200616871203No
406112233741.0215.3971.8Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. J D Dignam, R M Lebovitz, R G RoederNucleic Acids Res19836828386Yes
40737413741.088.9889.0Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. A T BrüngerNature199218481394Yes
408149603740.0352.5388.1Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Ben Langmead, Cole Trapnell, Mihai Pop, Steven L SalzbergGenome Biol200919261174Yes
40937353735.0100.62100.6Drug combination studies and their synergy quantification using the Chou-Talalay method. Ting-Chao ChouCancer Res201020068163Yes
41037323732.079.7879.8Scaling and assessment of data quality. Philip EvansActa Crystallogr D Biol Crystallogr200616369096No
41137313731.086.5486.5Novel proteinaceous infectious particles cause scrapie. S B PrusinerScience19826801762Yes
41237283728.0107.81107.8What's wrong with Bonferroni adjustments. T V PernegerBMJ19989553006No
41337213721.0107.17107.2Functions of DNA methylation: islands, start sites, gene bodies and beyond. Peter A JonesNat Rev Genet201222641018No
414148603715.0384.6396.2Global cancer statistics, 2002. D Max Parkin, Freddie Bray, J Ferlay, Paola PisaniCA Cancer J Clin200515761078Yes
41537123712.0117.48117.5genepop'007: a complete re-implementation of the genepop software for Windows and Linux. François RoussetMol Ecol Resour200821585727Yes
41674203710.0207.76103.9BEAST: Bayesian evolutionary analysis by sampling trees. Alexei J Drummond, Andrew RambautBMC Evol Biol200717996036Yes
41737053705.061.4961.5A membrane-filter technique for the detection of complementary DNA. D T DenhardtBiochem Biophys Res Commun19665963888Yes
41836983698.091.9892.0Origin and physiological roles of inflammation. Ruslan MedzhitovNature200818650913No
41936973697.066.9466.9Somatic generation of antibody diversity. S TonegawaNature19836300689No
42036943694.0167.24167.2Basic principles of ROC analysis. C E MetzSemin Nucl Med1978112681Yes
42136843684.0125.64125.6Generalized expectancies for internal versus external control of reinforcement. J B RotterPsychol Monogr19665340840No
42273453672.5182.9991.5Fast and accurate long-read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics201020080505Yes
42373383669.0161.8480.9Functional rafts in cell membranes. K Simons, E IkonenNature19979177342No
42473143657.0186.393.2The basics of epithelial-mesenchymal transition. Raghu Kalluri, Robert A WeinbergJ Clin Invest200919487818No
425109513650.3425.54141.8HISAT: a fast spliced aligner with low memory requirements. Daehwan Kim, Ben Langmead, Steven L SalzbergNat Methods201525751142Yes
42636473647.0105.47105.5Protective and damaging effects of stress mediators. B S McEwenN Engl J Med19989428819No
42736463646.0100.95101.0Biological roles of oligosaccharides: all of the theories are correct. A VarkiGlycobiology19938490246No
42836323632.088.6888.7I-TASSER server for protein 3D structure prediction. Yang ZhangBMC Bioinformatics200818215316Yes
429181583631.6698.26139.7The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. D J Buysse, C F Reynolds, T H Monk, S R Berman, D J KupferPsychiatry Res19892748771Yes
43072613630.5161.7380.9Inference of macromolecular assemblies from crystalline state. Evgeny Krissinel, Kim HenrickJ Mol Biol200717681537Yes
43172503625.0183.8791.9The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. R C Graham, M J KarnovskyJ Histochem Cytochem19665962951Yes
43236253625.0103.27103.3Graphene: status and prospects. A K GeimScience200919541989Yes
43336193619.0108.62108.6Inositol trisphosphate and diacylglycerol as second messengers. M J BerridgeBiochem J19846146314No
43472363618.0245.53122.8FLASH: fast length adjustment of short reads to improve genome assemblies. Tanja Magoč, Steven L SalzbergBioinformatics201121903629Yes
43572023601.0180.690.3An integrative theory of prefrontal cortex function. E K Miller, J D CohenAnnu Rev Neurosci200111283309No
43636003600.0101.07101.1EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. W KlimeschBrain Res Brain Res Rev199910209231No
43772003600.0173.6486.8The plant immune system. Jonathan D G Jones, Jeffery L DanglNature200617108957No
43871953597.5250.5125.2Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Laurent Excoffier, Heidi E L LischerMol Ecol Resour201021565059Yes
43935923592.084.5584.5Marrow stromal cells as stem cells for nonhematopoietic tissues. D J ProckopScience19979082988No
44035923592.093.7993.8The adolescent brain and age-related behavioral manifestations. L P SpearNeurosci Biobehav Rev200010817843No
441215143585.71006.3167.7Global cancer statistics, 2012. Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin JemalCA Cancer J Clin201525651787Yes
44235793579.084.4284.4Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Ting-Chao ChouPharmacol Rev200616968952No
44371103555.0287.13143.6The qualitative content analysis process. Satu Elo, Helvi KyngäsJ Adv Nurs200818352969Yes
44435483548.071.2171.2Mammalian neural stem cells. F H GageScience200010688783No
44570583529.0355.65177.8Microsomal lipid peroxidation. J A Buege, S D AustMethods Enzymol1978672633Yes
44635163516.066.9266.9Signal transduction by the JNK group of MAP kinases. R J DavisCell200011057897No
44735163516.0161.01161.0Estimation of average heterozygosity and genetic distance from a small number of individuals. M NeiGenetics197817248844Yes
448105453515.0257.2285.7Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Da Wei Huang, Brad T Sherman, Richard A LempickiNucleic Acids Res200919033363Yes
44970263513.0146.3373.2A new method for sequencing DNA. A M Maxam, W GilbertProc Natl Acad Sci U S A1977265521Yes
45035093509.073.4573.5Profile hidden Markov models. S R EddyBioinformatics19989918945No
45135083508.090.890.8Microglia: a sensor for pathological events in the CNS. G W KreutzbergTrends Neurosci19968843599No
452175203504.0495.3899.1Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. O P Hamill, A Marty, E Neher, B Sakmann, F J SigworthPflugers Arch19816270629Yes
45370023501.0126.7663.4Translating the histone code. T Jenuwein, C D AllisScience200111498575No
45435003500.054.2854.3Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. J D RowleyNature19734126434Yes
45535003500.079.7579.8Nonalcoholic fatty liver disease. Paul AnguloN Engl J Med200211961152No
45634973497.094.4194.4A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. Heng LiBioinformatics201121903627Yes
45734963496.059.0259.0Statistical estimations in enzyme kinetics. G N WilkinsonBiochem J196113785321Yes
45834953495.0104.41104.4Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. L R SquirePsychol Rev19921594723No
45934933493.054.9955.0Spectroscopic determination of tryptophan and tyrosine in proteins. H EdelhochBiochemistry19676049437Yes
46034923492.079.9479.9Glutamate uptake. N C DanboltProg Neurobiol200111369436No
46134893489.081.3381.3The dendritic cell system and its role in immunogenicity. R M SteinmanAnnu Rev Immunol19911910679No
46234863486.0101.12101.1Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Peter C AustinStat Med200919757444Yes
46334733473.0111.6111.6Modeling valuations for EuroQol health states. P DolanMed Care19979366889Yes
46434713471.085.0985.1The heat-shock response. S LindquistAnnu Rev Biochem19862427013No
46534713471.051.8951.9The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. J F WoessnerArch Biochem Biophys196113786180Yes
46669363468.077.5438.8Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. D H Hubel, T N WieselJ Physiol196214449617Yes
46734613461.095.9696.0Non-coding RNAs in human disease. Manel EstellerNat Rev Genet201122094949No
468103763458.7400.06133.4Cancer statistics, 2013. Rebecca Siegel, Deepa Naishadham, Ahmedin JemalCA Cancer J Clin201323335087Yes
46934543454.082.7382.7Neural networks and physical systems with emergent collective computational abilities. J J HopfieldProc Natl Acad Sci U S A19826953413Yes
47034503450.0134.59134.6Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. O W GriffithAnal Biochem19807416462Yes
47134493449.0101.72101.7Accelerated Profile HMM Searches. Sean R EddyPLoS Comput Biol201122039361Yes
47268783439.0162.6581.3"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. A P Feinberg, B VogelsteinAnal Biochem19846329026Yes
47334303430.0106.06106.1Health promotion by social cognitive means. Albert BanduraHealth Educ Behav200415090118Yes
47434283428.093.6593.7Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. R W MahleyScience19883283935No
47534213421.088.1988.2RELION: implementation of a Bayesian approach to cryo-EM structure determination. Sjors H W ScheresJ Struct Biol201223000701Yes
47668373418.5173.7286.9TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. T R Mosmann, R L CoffmanAnnu Rev Immunol19892523712No
47734183418.084.7684.8How do you feel? Interoception: the sense of the physiological condition of the body. A D CraigNat Rev Neurosci200212154366No
47834173417.074.3874.4Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. H F DvorakN Engl J Med19863537791No
47934153415.096.3196.3Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. Thomas WeltonChem Rev199911849019Yes
48034123412.085.3785.4The pathobiology of diabetic complications: a unifying mechanism. Michael BrownleeDiabetes200515919781No
481102353411.7464.69154.9Cancer statistics, 2015. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201525559415Yes
48234053405.00.00.0The magical number seven plus or minus two: some limits on our capacity for processing information. G A MillerPsychol Rev195613310704Yes
48334043404.00.00.0Some factors in the interpretation of protein denaturation. W KauzmannAdv Protein Chem195914404936Yes
48433953395.085.7385.7Biologic basis for interleukin-1 in disease. C A DinarelloBlood19968630372No
485101643388.070.2123.4The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. F C Greenwood, W M Hunter, J S GloverBiochem J196314097352Yes
486135203380.0436.02109.0A brief measure for assessing generalized anxiety disorder: the GAD-7. Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd LöweArch Intern Med200616717171Yes
48733753375.0107.03107.0DNA methylation age of human tissues and cell types. Steve HorvathGenome Biol201324138928Yes
48833673367.077.077.0Tolerance, danger, and the extended family. P MatzingerAnnu Rev Immunol19948011301No
489101013367.0251.8784.0Understanding the Warburg effect: the metabolic requirements of cell proliferation. Matthew G Vander Heiden, Lewis C Cantley, Craig B ThompsonScience200919460998No
49067333366.5133.8766.9Statistical significance for genomewide studies. John D Storey, Robert TibshiraniProc Natl Acad Sci U S A200312883005Yes
49133643364.0104.07104.1Psychometric properties of the strengths and difficulties questionnaire. R GoodmanJ Am Acad Child Adolesc Psychiatry200111699809Yes
492100913363.7365.98122.0Cancer statistics, 2012. Rebecca Siegel, Deepa Naishadham, Ahmedin JemalCA Cancer J Clin201222237781Yes
49367043352.0170.7185.4Long short-term memory. S Hochreiter, J SchmidhuberNeural Comput19979377276Yes
49433493349.068.4468.4The scanning model for translation: an update. M KozakJ Cell Biol19892645293No
49566893344.5184.6892.3Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Daniel R Zerbino, Ewan BirneyGenome Res200818349386Yes
49633343334.081.5381.5The basis of anisotropic water diffusion in the nervous system - a technical review. Christian BeaulieuNMR Biomed200212489094No
49733323332.068.1468.1Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. M KozakNucleic Acids Res19846694911Yes
49833253325.0122.77122.8You want to measure coping but your protocol's too long: consider the brief COPE. C S CarverInt J Behav Med199716250744Yes
49966383319.0127.3163.7The ubiquitin system. A Hershko, A CiechanoverAnnu Rev Biochem19989759494No
50033183318.083.8283.8Gene regulation by steroid hormones. M BeatoCell19892644044No
50166333316.5157.0778.5Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. C Tuerk, L GoldScience19902200121Yes
50266333316.5142.0471.0Angiogenesis in cancer and other diseases. P Carmeliet, R K JainNature200011001068No
50333163316.0148.67148.7The quality of care. How can it be assessed? A DonabedianJAMA19883045356No
50433063306.0104.07104.1Equilibrium Ultracentrifugation Of Dilute Solutions. D A YphantisBiochemistry196414155091Yes
50532983298.079.9479.9Wound healing--aiming for perfect skin regeneration. P MartinScience19979082989No
506130833270.8302.2675.6Improved methods for building protein models in electron density maps and the location of errors in these models. T A Jones, J Y Zou, S W Cowan, M KjeldgaardActa Crystallogr A19912025413Yes
50732683268.088.7588.8Hay fever, hygiene, and household size. D P StrachanBMJ19892513902Yes
50832653265.086.9987.0ABC transporters: from microorganisms to man. C F HigginsAnnu Rev Cell Biol19921282354No
50965223261.0204.03102.0Human malaria parasites in continuous culture. W Trager, J B JensenScience1976781840Yes
51032553255.063.9864.0The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Isaiah J FidlerNat Rev Cancer200312778135No
51132523252.093.4593.5Inositol trisphosphate and diacylglycerol: two interacting second messengers. M J BerridgeAnnu Rev Biochem19873304132No
51232483248.060.0360.0Cell signaling by receptor tyrosine kinases. J SchlessingerCell200011057895No
51332443244.0103.78103.8No adjustments are needed for multiple comparisons. K J RothmanEpidemiology19902081237Yes
51432413241.066.6766.7Alzheimer's disease is a synaptic failure. Dennis J SelkoeScience200212399581No
51532363236.076.276.2Photoelectrochemical cells. M GrätzelNature200111713540Yes
51632353235.069.8869.9Activators and target genes of Rel/NF-kappaB transcription factors. H L PahlOncogene199910602461No
51732303230.063.863.8STATs and gene regulation. J E DarnellScience19979287210No
51864443222.0218.59109.3Management of hepatocellular carcinoma: an update. Jordi Bruix, Morris ShermanHepatology201121374666No
51932123212.079.479.4The transforming growth factor-beta family. J MassaguéAnnu Rev Cell Biol19902177343No
520160323206.41172.76234.6MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro TamuraMol Biol Evol201829722887Yes
52132023202.065.6165.6CpG-rich islands and the function of DNA methylation. A P BirdNature19862423876No
52232023202.073.1573.2Mitochondrial formation of reactive oxygen species. Julio F TurrensJ Physiol200314561818No
52331993199.0111.39111.4Transformed up-down methods in psychoacoustics. H LevittJ Acoust Soc Am19715541744Yes
52431993199.095.4195.4adegenet: a R package for the multivariate analysis of genetic markers. Thibaut JombartBioinformatics200818397895Yes
52563873193.5199.5899.8Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. C Beauchamp, I FridovichAnal Biochem19714943714Yes
52631903190.066.9667.0Protein folding and misfolding. Christopher M DobsonNature200314685248No
52763753187.5174.4887.2Projections of global mortality and burden of disease from 2002 to 2030. Colin D Mathers, Dejan LoncarPLoS Med200617132052Yes
52831823182.096.4696.5Development of a classification system for periodontal diseases and conditions. G C ArmitageAnn Periodontol199910863370No
52931693169.0102.01102.0Essential oils: their antibacterial properties and potential applications in foods--a review. Sara BurtInt J Food Microbiol200415246235No
53031533153.066.7466.7Cardiac excitation-contraction coupling. Donald M BersNature200211805843No
53163033151.5199.5499.8Complex network measures of brain connectivity: uses and interpretations. Mikail Rubinov, Olaf SpornsNeuroimage201019819337Yes
53231403140.073.9273.9WHAT IF: a molecular modeling and drug design program. G VriendJ Mol Graph19902268628Yes
53362803140.0196.8598.4The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Stephen B Edge, Carolyn C ComptonAnn Surg Oncol201020180029No
53431363136.00.00.0Diffusion-in-gel methods for immunological analysis. O OuchterlonyProg Allergy195813578996Yes
53562633131.5132.8366.4Toll-like receptor signalling. Shizuo Akira, Kiyoshi TakedaNat Rev Immunol200415229469No
53631283128.066.3966.4Mechanisms of angiogenesis and arteriogenesis. P CarmelietNat Med200010742145No
53731193119.027.1327.1Gene action in the X-chromosome of the mouse (Mus musculus L.). M F LyonNature196113764598Yes
53831183118.066.0266.0Angiogenesis in health and disease. Peter CarmelietNat Med200312778163No
53931163116.096.1596.2Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Sarah E BarlowPediatrics200718055651Yes
54031073107.089.0589.0Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. Y X FuGenetics19979335623Yes
54193033101.0313.09104.4Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. R M Palmer, A G Ferrige, S MoncadaNature19873495737Yes
54262023101.0100.8550.4Pain mechanisms: a new theory. R Melzack, P D WallScience19655320816No
54361913095.5150.8375.4In vitro selection of RNA molecules that bind specific ligands. A D Ellington, J W SzostakNature19901697402Yes
54430953095.0119.61119.6Half a century of research on the Stroop effect: an integrative review. C M MacLeodPsychol Bull19912034749No
54561903095.0203.41101.7Measuring agreement in method comparison studies. J M Bland, D G AltmanStat Methods Med Res199910501650No
54692703090.0194.064.7Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Benjamin P Lewis, Christopher B Burge, David P BartelCell200515652477Yes
54730893089.085.8785.9Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. S W KesslerJ Immunol19751102604Yes
54861713085.5148.9874.5Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Weizhong Li, Adam GodzikBioinformatics200616731699Yes
549123353083.8469.38117.3APACHE II: a severity of disease classification system. W A Knaus, E A Draper, D P Wagner, J E ZimmermanCrit Care Med19853928249Yes
55061603080.0181.1190.6Complex brain networks: graph theoretical analysis of structural and functional systems. Ed Bullmore, Olaf SpornsNat Rev Neurosci200919190637No
55130793079.076.276.2Recent advances with liposomes as pharmaceutical carriers. Vladimir P TorchilinNat Rev Drug Discov200515688077No
55261563078.0155.7677.9Voxel-based morphometry--the methods. J Ashburner, K J FristonNeuroimage200010860804No
55361543077.0150.0975.0Exploring the full spectrum of macrophage activation. David M Mosser, Justin P EdwardsNat Rev Immunol200819029990No
55430733073.054.1654.2Automated electron microscope tomography using robust prediction of specimen movements. David N MastronardeJ Struct Biol200516182563Yes
55530713071.072.7972.8Obesity as a medical problem. P G KopelmanNature200010766250No
55661333066.553.4126.7The serial cultivation of human diploid cell strains. L Hayflick, P S MoorheadExp Cell Res196113905658Yes
55791903063.3259.586.5Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. G Evanno, S Regnaut, J GoudetMol Ecol200515969739Yes
55861263063.0136.3368.2MicroRNA signatures in human cancers. George A Calin, Carlo M CroceNat Rev Cancer200617060945No
55930593059.0108.03108.0The Danish Civil Registration System. Carsten Bøcker PedersenScand J Public Health201121775345Yes
56030583058.089.4589.5Hepatocellular carcinoma. Hashem B El-SeragN Engl J Med201121992124No
56160993049.5108.2354.1The language of covalent histone modifications. B D Strahl, C D AllisNature200010638745Yes
56230453045.070.5670.6Cadherin cell adhesion receptors as a morphogenetic regulator. M TakeichiScience19912006419No
56330453045.0104.7104.7The processing-speed theory of adult age differences in cognition. T A SalthousePsychol Rev19968759042No
56430413041.0122.9122.9Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. T E MoffittPsychol Rev19938255953No
56560553027.5161.9181.0The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Taro Kawai, Shizuo AkiraNat Immunol201020404851No
56660493024.5187.9594.0Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. K Tamura, M NeiMol Biol Evol19938336541Yes
56760493024.5178.1789.1Electrochemical photolysis of water at a semiconductor electrode. A Fujishima, K HondaNature197212635268Yes
56830183018.0108.59108.6Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. Joseph P WeirJ Strength Cond Res200515705040No
56930173017.076.2576.2Cellular and molecular mechanisms of fibrosis. T A WynnJ Pathol200818161745No
57030153015.0107.2107.2A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. S HakomoriJ Biochem196414135466Yes
57130123012.00.00.0A study of fixation for electron microscopy. G E PaladeJ Exp Med195214927794Yes
57260223011.00.00.0A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. S Reitman, S FrankelAm J Clin Pathol195713458125Yes
57360193009.5180.290.1mTOR signaling in growth control and disease. Mathieu Laplante, David M SabatiniCell201222500797No
57490273009.0177.7359.2Significance analysis of microarrays applied to the ionizing radiation response. V G Tusher, R Tibshirani, G ChuProc Natl Acad Sci U S A200111309499Yes
57530053005.064.864.8TGFbeta in Cancer. Joan MassaguéCell200818662538No
57629932993.095.0795.1An empirical correction for absorption anisotropy. R H BlessingActa Crystallogr A19957702794Yes
57729882988.072.6472.6The resurgence of platinum-based cancer chemotherapy. Lloyd KellandNat Rev Cancer200717625587No
57829832983.0101.99102.0Measurement of pain. E C HuskissonLancet19744139420Yes
579119222980.5282.6470.7Haploview: analysis and visualization of LD and haplotype maps. J C Barrett, B Fry, J Maller, M J DalyBioinformatics200515297300Yes
58029802980.055.9255.9Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. P SchuckBiophys J200010692345Yes
58129792979.00.00.0Catheter replacement of the needle in percutaneous arteriography; a new technique. S I SeldingerActa radiol195313057644Yes
58229782978.052.7852.8The gel-filtration behaviour of proteins related to their molecular weights over a wide range. P AndrewsBiochem J19655862401Yes
58329782978.069.0469.0Chemokines--chemotactic cytokines that mediate inflammation. A D LusterN Engl J Med19989459648No
58459552977.5252.72126.4Assessment of outcome after severe brain damage. B Jennett, M BondLancet197546957Yes
58559522976.0141.1570.6Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. T C Chou, P TalalayAdv Enzyme Regul19846382953Yes
58659482974.0125.4362.7Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. D B Smith, K S JohnsonGene19883047011Yes
58729682968.0134.52134.5The short-form McGill Pain Questionnaire. Ronald MelzackPain19873670870Yes
58859352967.5134.2367.1Oxidants, oxidative stress and the biology of ageing. T Finkel, N J HolbrookNature200011089981No
589237332966.6516.6464.6The Protein Data Bank. H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E BourneNucleic Acids Res200010592235Yes
59029632963.058.6158.6Toll-like receptors and innate immunity. R MedzhitovNat Rev Immunol200111905821No
59188812960.3207.0769.0TopHat: discovering splice junctions with RNA-Seq. Cole Trapnell, Lior Pachter, Steven L SalzbergBioinformatics200919289445Yes
59229602960.078.3978.4Accurate Coulomb-fitting basis sets for H to Rn. Florian WeigendPhys Chem Chem Phys200616633586Yes
59329522952.090.8190.8Matrix metalloproteinases and their inhibitors in connective tissue remodeling. J F WoessnerFASEB J19911850705No
59429512951.054.7954.8RNA interference. Gregory J HannonNature200212110901No
595265412949.0571.3563.5Cytoscape: a software environment for integrated models of biomolecular interaction networks. Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey IdekerGenome Res200314597658Yes
59629492949.0101.41101.4What is value in health care? Michael E PorterN Engl J Med201021142528Yes
59788422947.3242.4680.8Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Y Gavrieli, Y Sherman, S A Ben-SassonJ Cell Biol19921400587Yes
59858772938.5184.7492.4Tissue engineering. R Langer, J P VacantiScience19938493529No
59929372937.080.0480.0The nuclear factor NF-kappaB pathway in inflammation. Toby LawrenceCold Spring Harb Perspect Biol200920457564No
60058702935.0124.6562.3Emergence of scaling in random networks A L Barabasi, R AlbertScience199910521342Yes
60129322932.073.0773.1Optimal two-stage designs for phase II clinical trials. R SimonControl Clin Trials19892702835Yes
60287602920.0286.1195.4Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. R A Deyo, D C Cherkin, M A CiolJ Clin Epidemiol19921607900Yes
60358102905.0162.7881.4Inositol trisphosphate, a novel second messenger in cellular signal transduction. M J Berridge, R F IrvineNature19846095092No
60458092904.5173.6286.8The fluid mosaic model of the structure of cell membranes. S J Singer, G L NicolsonScience19724333397Yes
60587052901.7215.0771.7ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Kai Wang, Mingyao Li, Hakon HakonarsonNucleic Acids Res201020601685Yes
60629012901.088.3488.3Estimation of metabolite concentrations from localized in vivo proton NMR spectra. S W ProvencherMagn Reson Med19938139448Yes
60728972897.060.1760.2Principles of CDK regulation. D O MorganNature19957877684No
60828942894.00.00.0The genetical structure of populations. S WrightAnn Eugen195124540312Yes
60986812893.70.00.0The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. R J Havel, H A Eder, J H BragdonJ Clin Invest195513252080Yes
61028912891.065.3265.3Autophagy: process and function. Noboru MizushimaGenes Dev200718006683No
611115582889.5423.9106.0Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg LangBehav Res Methods200919897823Yes
61228892889.070.2570.2Phase separation of integral membrane proteins in Triton X-114 solution. C BordierJ Biol Chem19816257680Yes
61357652882.5251.81125.9GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. Rod Peakall, Peter E SmouseBioinformatics201222820204Yes
61428822882.086.4686.5Implications of normal brain development for the pathogenesis of schizophrenia. D R WeinbergerArch Gen Psychiatry19873606332Yes
61586432881.0164.0654.7Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Ron Edgar, Michael Domrachev, Alex E LashNucleic Acids Res200211752295Yes
61628782878.068.4968.5Structure and function of telomeres. E H BlackburnNature19911708110No
61786342878.0198.366.1The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. R C Lee, R L Feinbaum, V AmbrosCell19938252621Yes
61828752875.051.2351.2One-step gene disruption in yeast. R J RothsteinMethods Enzymol19836310324Yes
61928742874.083.2383.2Efficient methods to compute genomic predictions. P M VanRadenJ Dairy Sci200818946147Yes
62028712871.061.8961.9Inflammatory bowel disease. Daniel K PodolskyN Engl J Med200212167685No
62157372868.5126.8763.4Oncomirs - microRNAs with a role in cancer. Aurora Esquela-Kerscher, Frank J SlackNat Rev Cancer200616557279No
62228682868.095.6295.6Role of oxidative stress in development of complications in diabetes. J W BaynesDiabetes19912010041No
62328682868.043.5343.5Towards a network theory of the immune system. N K JerneAnn Immunol (Paris)19744142565No
62428682868.0100.13100.1Measures of reliability in sports medicine and science. W G HopkinsSports Med200010907753Yes
62528672867.029.3429.3Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. P MitchellNature196113771349Yes
62628632863.050.4850.5A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. E A GehanBiometrika196514341275Yes
62728602860.00.00.0Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. W C SchneiderJ Biol Chem194521005736Yes
62857142857.0120.0460.0Inflammation and cancer: back to Virchow? F Balkwill, A MantovaniLancet200111229684No
62928572857.00.00.0A study of the adrenotropic receptors. R P AhlquistAm J Physiol194818882199Yes
63028562856.052.6252.6Genome maintenance mechanisms for preventing cancer. J H HoeijmakersNature200111357144No
63157052852.5180.9290.5Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. R M Ryan, E L DeciAm Psychol200011392867Yes
63285522850.7255.7785.3Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. G Fairbanks, T L Steck, D F WallachBiochemistry19714326772Yes
63356952847.5145.0772.5Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Glowinski, L L IversenJ Neurochem19665950056Yes
63428462846.067.1767.2MapChart: software for the graphical presentation of linkage maps and QTLs. R E VoorripsJ Hered200212011185Yes
63528412841.046.5146.5A Rationale And Test For The Number Of Factors In Factor Analysis. J L HornPsychometrika196514306381Yes
63628402840.093.593.5Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. B E MurphyJ Clin Endocrinol Metab19674291524Yes
63756802840.0247.05123.5Revised methods for the Salmonella mutagenicity test. D M Maron, B N AmesMutat Res19836341825Yes
63828402840.00.00.0Notes on sugar determination. M SmogyiJ Biol Chem195214938350Yes
63956712835.5149.1674.6Pattern recognition receptors and inflammation. Osamu Takeuchi, Shizuo AkiraCell201020303872No
64028332833.054.7454.7A gene complex controlling segmentation in Drosophila. E B LewisNature1978103000Yes
64128292829.064.2564.2Calcium signaling. David E ClaphamCell200718083096No
64256362818.0149.2374.6Unified segmentation. John Ashburner, Karl J FristonNeuroimage200515955494Yes
643112712817.8333.0483.3Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Qiong Wang, George M Garrity, James M Tiedje, James R ColeAppl Environ Microbiol200717586664Yes
64456332816.5209.13104.6The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. P F Lovibond, S H LovibondBehav Res Ther19957726811Yes
64528162816.060.7460.7Nuclear factor-kappaB in cancer development and progression. Michael KarinNature200616724054No
64628102810.053.6353.6Elastic properties of lipid bilayers: theory and possible experiments. W HelfrichZ Naturforsch C19734273690Yes
64784292809.7431.25143.8Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. P J Van Soest, J B Robertson, B A LewisJ Dairy Sci19911660498No
64828082808.070.9370.9Analysis of gene diversity in subdivided populations. M NeiProc Natl Acad Sci U S A19734519626Yes
64928072807.055.6555.6Papillomaviruses and cancer: from basic studies to clinical application. Harald zur HausenNat Rev Cancer200212044010No
65028062806.055.4455.4Interleukin-12 and the regulation of innate resistance and adaptive immunity. Giorgio TrinchieriNat Rev Immunol200312563297No
65128052805.065.6165.6Modularity and community structure in networks. M E J NewmanProc Natl Acad Sci U S A200616723398Yes
65256022801.0152.2876.1The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. J Vieira, J MessingGene19826295879Yes
65328002800.093.4593.5Stereotaxic mapping of the monoamine pathways in the rat brain. U UngerstedtActa Physiol Scand Suppl19714109331Yes
65427982798.084.8484.8Primate models of movement disorders of basal ganglia origin. M R DeLongTrends Neurosci19901695404No
65555952797.5126.7663.4Caspases: enemies within. N A Thornberry, Y LazebnikScience19989721091No
65627952795.075.8775.9Separation of leukocytes from blood and bone marrow. Introduction. A BöyumScand J Clin Lab Invest Suppl19685707208Yes
65755782789.0112.4156.2Establishment in culture of pluripotential cells from mouse embryos. M J Evans, M H KaufmanNature19817242681Yes
65855782789.077.838.9A method for determining the sedimentation behavior of enzymes: application to protein mixtures. R G Martin, B N AmesJ Biol Chem196113767412Yes
65927882788.065.2565.2Molecular chaperones in cellular protein folding. F U HartlNature19968637592No
660111412785.2297.5274.4Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. P W Rigby, M Dieckmann, C Rhodes, P BergJ Mol Biol1977881736Yes
66155672783.5192.5696.3A method of comparing the areas under receiver operating characteristic curves derived from the same cases. J A Hanley, B J McNeilRadiology19836878708Yes
66255662783.0172.986.5Computed tomography--an increasing source of radiation exposure. David J Brenner, Eric J HallN Engl J Med200718046031No
66327822782.00.00.0Efficient trace-labelling of proteins with iodine. A S McFARLANENature195813566175Yes
66427802780.047.4647.5Mechanisms underlying ubiquitination. C M PickartAnnu Rev Biochem200111395416No
66527792779.0115.79115.8Colorimetric assay of catalase. A K SinhaAnal Biochem19724556490Yes
66655502775.0133.2766.6Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. S Marklund, G MarklundEur J Biochem19744215654Yes
66755482774.0177.4988.7Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. J Sedlak, R H LindsayAnal Biochem19684973948Yes
668110842771.0341.6285.4Cancer statistics, 2010. Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth WardCA Cancer J Clin201020610543Yes
66927652765.061.7461.7Salt and drought stress signal transduction in plants. Jian-Kang ZhuAnnu Rev Plant Biol200212221975No
67027652765.00.00.0Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. L SvennerholmBiochim Biophys Acta195713436486Yes
67127632763.0112.88112.9Microplastics in the marine environment. Anthony L AndradyMar Pollut Bull201121742351No
67227592759.0124.84124.8Detecting alcoholism. The CAGE questionnaire. J A EwingJAMA19846471323Yes
67327582758.0105.16105.2A simple technique for demonstrating centromeric heterochromatin. A T SumnerExp Cell Res19724117921Yes
67482742758.0189.163.0Pathogen recognition and innate immunity. Shizuo Akira, Satoshi Uematsu, Osamu TakeuchiCell200616497588No
67527572757.066.4566.5Cell death during development of the nervous system. R W OppenheimAnnu Rev Neurosci19912031577No
67655112755.5109.5454.8Innate immune recognition. Charles A Janeway, Ruslan MedzhitovAnnu Rev Immunol200211861602No
67755052752.5133.6366.8Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. D Hanahan, J FolkmanCell19968756718No
67854962748.0129.8664.9Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. F W Studier, B A MoffattJ Mol Biol19863537305Yes
67954902745.085.2442.6A modified uronic acid carbazole reaction. T Bitter, H M MuirAnal Biochem196213971270Yes
68027432743.068.3968.4Models for the specific adhesion of cells to cells. G I BellScience1978347575No
681301282738.9628.2557.1Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P MesirovProc Natl Acad Sci U S A200516199517Yes
68227362736.079.0579.0Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). Gunther EysenbachJ Med Internet Res200415471760No
68354672733.5167.0283.5Glutathione. A Meister, M E AndersonAnnu Rev Biochem19836137189No
68454602730.0197.4898.7Longitudinal data analysis for discrete and continuous outcomes. S L Zeger, K Y LiangBiometrics19863719049Yes
68527282728.069.1969.2The genetic legacy of the Quaternary ice ages. G HewittNature200010879524No
68627232723.070.3370.3Predictive reward signal of dopamine neurons. W SchultzJ Neurophysiol19989658025No
68727222722.053.1753.2The danger model: a renewed sense of self. Polly MatzingerScience200211951032Yes
68881542718.0353.31117.8Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. J L Cox, J M Holden, R SagovskyBr J Psychiatry19873651732Yes
68954342717.0107.5253.8High-efficiency transformation of mammalian cells by plasmid DNA. C Chen, H OkayamaMol Cell Biol19873670292Yes
69027172717.061.4661.5Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. S A BustinJ Mol Endocrinol200011013345No
69127152715.0102.56102.6KDIGO clinical practice guidelines for acute kidney injury. Arif KhwajaNephron Clin Pract201222890468No
69254262713.0150.675.3Adherence to medication. Lars Osterberg, Terrence BlaschkeN Engl J Med200516079372No
69381372712.3174.7658.3Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. C M Gorman, L F Moffat, B H HowardMol Cell Biol19826960240Yes
69427102710.068.4768.5Dietary pattern analysis: a new direction in nutritional epidemiology. Frank B HuCurr Opin Lipidol200211790957No
69527092709.058.6558.6Bone resorption by osteoclasts. S L TeitelbaumScience200010968780No
69654182709.0126.7863.4Autophagy in the pathogenesis of disease. Beth Levine, Guido KroemerCell200818191218No
69727082708.062.9763.0Memory--a century of consolidation. J L McGaughScience200010634773No
69854002700.0168.9284.5Accurate and simple analytic representation of the electron-gas correlation energy. J P Perdew, Y WangPhys Rev B Condens Matter199210001404Yes
69926982698.0103.04103.0Role of nrf2 in oxidative stress and toxicity. Qiang MaAnnu Rev Pharmacol Toxicol201323294312No
70026942694.060.6760.7Cell adhesion: the molecular basis of tissue architecture and morphogenesis. B M GumbinerCell19968608588No
70180822694.0200.866.9MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Sudhir Kumar, Koichiro Tamura, Masatoshi NeiBrief Bioinform200415260895Yes
70253752687.5257.57128.8Stress, social support, and the buffering hypothesis. S Cohen, T A WillsPsychol Bull19853901065No
70353732686.5153.8476.9The Social Readjustment Rating Scale. T H Holmes, R H RaheJ Psychosom Res19676059863Yes
704107332683.2227.9457.0Cluster analysis and display of genome-wide expression patterns. M B Eisen, P T Spellman, P O Brown, D BotsteinProc Natl Acad Sci U S A19989843981Yes
70580402680.0199.066.3Canonical sampling through velocity rescaling. Giovanni Bussi, Davide Donadio, Michele ParrinelloJ Chem Phys200717212484Yes
706187472678.1719.4102.8limma powers differential expression analyses for RNA-sequencing and microarray studies. Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K SmythNucleic Acids Res201525605792Yes
70726782678.075.7875.8Parkinson's disease: clinical features and diagnosis. J JankovicJ Neurol Neurosurg Psychiatry200818344392No
70826762676.060.2360.2Prostaglandins and leukotrienes: advances in eicosanoid biology. C D FunkScience200111729303No
709240432671.4770.5885.6STAR: ultrafast universal RNA-seq aligner. Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R GingerasBioinformatics201323104886Yes
71026682668.080.7280.7SF-36 health survey update. J E WareSpine (Phila Pa 1976)200011124729No
711106542663.5314.6878.7Establishing a standard definition for child overweight and obesity worldwide: international survey. T J Cole, M C Bellizzi, K M Flegal, W H DietzBMJ200010797032Yes
71226582658.051.5351.5Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Shimon SakaguchiAnnu Rev Immunol200415032588No
71326572657.068.7568.8Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. P CuatrecasasJ Biol Chem19705432796Yes
71426542654.023.3223.3Satellite cell of skeletal muscle fibers. A MauroJ Biophys Biochem Cytol196113768451Yes
71526502650.057.457.4On the number of segregating sites in genetical models without recombination. G A WattersonTheor Popul Biol19751145509Yes
71626492649.069.8569.8The magical number 4 in short-term memory: a reconsideration of mental storage capacity. N CowanBehav Brain Sci200111515286Yes
71726412641.063.7263.7T cell exhaustion. E John WherryNat Immunol201121739672No
71826382638.065.8365.8The nerve growth factor 35 years later. R Levi-MontalciniScience19873306916No
71952762638.0155.8577.9Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. Jeng-Da Chai, Martin Head-GordonPhys Chem Chem Phys200818989472Yes
72026372637.060.2760.3Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. G P SmithScience19854001944Yes
72152742637.0180.7890.4The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. S H Downs, N BlackJ Epidemiol Community Health19989764259Yes
72226342634.081.7781.8What are the functional consequences of neurocognitive deficits in schizophrenia? M F GreenAm J Psychiatry19968610818No
72352572628.50.00.0Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. J D Watson, F H CrickNature195313054692Yes
72452492624.5136.5368.3Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. L A Greene, A S TischlerProc Natl Acad Sci U S A19761065897Yes
72552492624.5181.6490.8Extracellular vesicles: exosomes, microvesicles, and friends. Graça Raposo, Willem StoorvogelJ Cell Biol201323420871No
72626242624.077.8577.8The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Claudio HetzNat Rev Mol Cell Biol201222251901No
72726212621.0104.74104.7The biology of oxygen radicals. I FridovichScience1978210504Yes
72852402620.0117.1158.6Signal transduction by receptors with tyrosine kinase activity. A Ullrich, J SchlessingerCell19902158859No
72952352617.5207.19103.6A feature-integration theory of attention. A M Treisman, G GeladeCogn Psychol19807351125Yes
73026122612.063.4963.5Molecular basis of bacterial outer membrane permeability revisited. Hiroshi NikaidoMicrobiol Mol Biol Rev200314665678No
73152232611.5180.4390.2A simple, rapid, and sensitive DNA assay procedure. C Labarca, K PaigenAnal Biochem19806158890Yes
73226112611.081.4181.4Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. B SamuelssonScience19836301011Yes
73352212610.50.00.0Some quantitative uses of drug antagonists. O Arunlakshana, H O SchildBr J Pharmacol Chemother195913651579Yes
73426102610.0116.82116.8The membrane actions of anesthetics and tranquilizers. P SeemanPharmacol Rev19724565956No
73526102610.058.9759.0Vascular endothelial growth factor: basic science and clinical progress. Napoleone FerraraEndocr Rev200415294883No
73626062606.074.574.5Formation and Structure of Self-Assembled Monolayers. Abraham UlmanChem Rev199611848802Yes
73752092604.5159.1579.6Rapid isolation of high molecular weight plant DNA. M G Murray, W F ThompsonNucleic Acids Res19807433111Yes
73825972597.055.6555.6G1 phase progression: cycling on cue. C J SherrCell19947954821No
739155502591.7349.0758.2Phaser crystallographic software. Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J ReadJ Appl Crystallogr200719461840Yes
74051832591.5101.5150.8Untangling the ErbB signalling network. Y Yarden, M X SliwkowskiNat Rev Mol Cell Biol200111252954No
74151822591.0106.753.4MicroRNAs: small RNAs with a big role in gene regulation. Lin He, Gregory J HannonNat Rev Genet200415211354No
74225892589.062.2362.2Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. E C ButcherCell19911760836No
74325832583.062.5462.5Cancer nanotechnology: opportunities and challenges. Mauro FerrariNat Rev Cancer200515738981No
74425822582.00.00.0The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. R R PorterBiochem J195914434282Yes
74551582579.0159.6379.8The L-arginine-nitric oxide pathway. S Moncada, A HiggsN Engl J Med19937504210No
74625772577.073.0873.1Delayed neuronal death in the gerbil hippocampus following ischemia. T KirinoBrain Res19827093691Yes
74725722572.056.9256.9Epigenetics in cancer. Manel EstellerN Engl J Med200818337604No
74851322566.0166.5183.3The neural basis of drug craving: an incentive-sensitization theory of addiction. T E Robinson, K C BerridgeBrain Res Brain Res Rev19938401595No
74925632563.053.5253.5Evolving concepts of rheumatoid arthritis. Gary S FiresteinNature200312748655No
75025612561.036.3536.4The catecholamine hypothesis of affective disorders: a review of supporting evidence. J J SchildkrautAm J Psychiatry19655319766No
75125602560.050.3450.3Tumour-educated macrophages promote tumour progression and metastasis. Jeffrey W PollardNat Rev Cancer200414708027No
75225592559.068.2968.3Dominant forces in protein folding. K A DillBiochemistry19902207096No
75325592559.00.00.0The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. M L AnsonJ Gen Physiol193819873094Yes
75451162558.080.8240.4A general method applicable to the search for similarities in the amino acid sequence of two proteins. S B Needleman, C D WunschJ Mol Biol19705420325Yes
75525582558.00.00.0Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. O SmithiesBiochem J195513276348Yes
75625572557.0103.73103.7Qualitative research. Introducing focus groups. J KitzingerBMJ19957633241Yes
75776442548.0227.6175.9FastTree 2--approximately maximum-likelihood trees for large alignments. Morgan N Price, Paramvir S Dehal, Adam P ArkinPLoS One201020224823Yes
75825472547.0100.82100.8Central sensitization: implications for the diagnosis and treatment of pain. Clifford J WoolfPain201120961685No
75925462546.073.0873.1Stress, adaptation, and disease. Allostasis and allostatic load. B S McEwenAnn N Y Acad Sci19989629234No
76025392539.026.6326.6The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. S BoydenJ Exp Med196213872176Yes
76125382538.071.2171.2Two-sided confidence intervals for the single proportion: comparison of seven methods. R G NewcombeStat Med19989595616Yes
76225362536.051.9151.9Telomere measurement by quantitative PCR. Richard M CawthonNucleic Acids Res200212000852Yes
76325352535.050.9450.9Universal control mechanism regulating onset of M-phase. P NurseNature19902138713No
76476002533.3261.7187.2Effect of the damping function in dispersion corrected density functional theory. Stefan Grimme, Stephan Ehrlich, Lars GoerigkJ Comput Chem201121370243Yes
76525312531.055.0655.1Angiogenesis in life, disease and medicine. Peter CarmelietNature200516355210No
76650602530.0273.39136.7A diagnostic interview: the schedule for affective disorders and schizophrenia. J Endicott, R L SpitzerArch Gen Psychiatry1978678037Yes
76725302530.077.7177.7Secretory products of macrophages. C F NathanJ Clin Invest19873543052No
76850492524.5230.77115.4Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. J Silness, H LoeActa Odontol Scand196414158464Yes
76950422521.0124.9862.5Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Klaus Apel, Heribert HirtAnnu Rev Plant Biol200415377225No
77025212521.070.2470.2Physiology and neurobiology of stress and adaptation: central role of the brain. Bruce S McEwenPhysiol Rev200717615391No
771100792519.8459.08114.8IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang MinhMol Biol Evol201525371430Yes
772100732518.21517.45379.4Cancer Statistics, 2021. Rebecca L Siegel, Kimberly D Miller, Hannah E Fuchs, Ahmedin JemalCA Cancer J Clin202133433946Yes
77325182518.087.3287.3A computational approach to edge detection. J CannyIEEE Trans Pattern Anal Mach Intell198621869365Yes
77425052505.061.5261.5A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Pascal FriesTrends Cogn Sci200516150631No
77525042504.079.0479.0Social cognitive theory: an agentic perspective. A BanduraAnnu Rev Psychol200111148297Yes
77625032503.070.0170.0Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. P CorreaCancer Res19921458460No
77725012501.082.2182.2A rating instrument for anxiety disorders. W W ZungPsychosomatics19715172928Yes
77824972497.044.9745.0Wnt signaling and cancer. P PolakisGenes Dev200010921899No
77949932496.5179.2589.6Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. P J Fraker, J C SpeckBiochem Biophys Res Commun1978637870Yes
78024912491.077.7977.8The free-energy principle: a unified brain theory? Karl FristonNat Rev Neurosci201020068583No
78199562489.0412.17103.0Cancer statistics, 2014. Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin JemalCA Cancer J Clin201424399786Yes
78224862486.0112.0112.0Oxygen-dependent microbial killing by phagocytes (first of two parts). B M BabiorN Engl J Med197824176Yes
78324852485.065.8565.8Evaluating the quality of medical care. A DonabedianMilbank Mem Fund Q19665338568No
78424832483.081.2881.3Perceived exertion as an indicator of somatic stress. G BorgScand J Rehabil Med19705523831Yes
78549632481.5141.4370.7Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. J V Durnin, J WomersleyBr J Nutr19744843734Yes
78624792479.0106.82106.8Statistics corner: A guide to appropriate use of correlation coefficient in medical research. M M MukakaMalawi Med J201223638278Yes
78749532476.5119.159.5Calculation of protein extinction coefficients from amino acid sequence data. S C Gill, P H von HippelAnal Biochem19892610349Yes
78849482474.099.4349.7Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. D Bonnet, J E DickNat Med19979212098Yes
78949462473.096.3648.2CDK inhibitors: positive and negative regulators of G1-phase progression. C J Sherr, J M RobertsGenes Dev199910385618No
79073822460.7201.2767.1Quantum mechanical continuum solvation models. Jacopo Tomasi, Benedetta Mennucci, Roberto CammiChem Rev200516092826Yes
79124552455.0147.6147.6Hepatocellular Carcinoma. Augusto VillanuevaN Engl J Med201930970190No
79224532453.054.4654.5Social controls on cell survival and cell death. M C RaffNature19921557121No
79348972448.5215.12107.6Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. N S Jacobson, P TruaxJ Consult Clin Psychol19912002127Yes
79473432447.7184.8161.6RNA-Seq: a revolutionary tool for transcriptomics. Zhong Wang, Mark Gerstein, Michael SnyderNat Rev Genet200919015660No
79524432443.047.2647.3Getting started with yeast. F ShermanMethods Enzymol19912005794Yes
79624432443.00.00.0Transduction of linked genetic characters of the host by bacteriophage P1. E S LennoxVirology195513267987Yes
79724422442.065.7865.8Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. H G GratznerScience19827123245Yes
79873252441.7195.9665.3Immunity, inflammation, and cancer. Sergei I Grivennikov, Florian R Greten, Michael KarinCell201020303878No
79948832441.5114.057.0Myeloid-derived suppressor cells as regulators of the immune system. Dmitry I Gabrilovich, Srinivas NagarajNat Rev Immunol200919197294No
80048622431.0145.0572.5SPSS and SAS procedures for estimating indirect effects in simple mediation models. Kristopher J Preacher, Andrew F HayesBehav Res Methods Instrum Comput200415641418Yes
80124292429.060.9861.0Immunological and inflammatory functions of the interleukin-1 family. Charles A DinarelloAnnu Rev Immunol200919302047No
80224232423.058.058.0Causes and consequences of microRNA dysregulation in cancer. Carlo M CroceNat Rev Genet200919763153No
80396742418.5254.5563.6GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. Berk Hess, Carsten Kutzner, David van der Spoel, Erik LindahlJ Chem Theory Comput200826620784Yes
80424152415.0122.08122.1Conservation of resources. A new attempt at conceptualizing stress. S E HobfollAm Psychol19892648906No
80548272413.5119.9460.0A global optimisation method for robust affine registration of brain images. M Jenkinson, S SmithMed Image Anal200111516708Yes
80648272413.5125.5662.8UniFrac: a new phylogenetic method for comparing microbial communities. Catherine Lozupone, Rob KnightAppl Environ Microbiol200516332807Yes
80772322410.7206.268.7Bacterial biofilms: a common cause of persistent infections. J W Costerton, P S Stewart, E P GreenbergScience199910334980No
80824092409.092.4292.4Missing data analysis: making it work in the real world. John W GrahamAnnu Rev Psychol200918652544No
80948122406.0107.4853.7Signal integration in the endoplasmic reticulum unfolded protein response. David Ron, Peter WalterNat Rev Mol Cell Biol200717565364No
81024012401.052.2852.3Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. T HunterCell19957834742No
81147992399.593.0746.5The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Igor Vivanco, Charles L SawyersNat Rev Cancer200212094235No
81271962398.7186.2662.1Cortical surface-based analysis. I. Segmentation and surface reconstruction. A M Dale, B Fischl, M I SerenoNeuroimage19999931268Yes
81323982398.076.8376.8Plant products as antimicrobial agents. M M CowanClin Microbiol Rev199910515903No
81447852392.594.3847.2Lipid rafts and signal transduction. K Simons, D ToomreNat Rev Mol Cell Biol200011413487No
81523922392.00.00.0The information capacity of the human motor system in controlling the amplitude of movement. P M FittsJ Exp Psychol195413174710Yes
81647842392.0119.8759.9The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Karen Bedard, Karl-Heinz KrausePhysiol Rev200717237347No
81723862386.094.2694.3The biology and function of fibroblasts in cancer. Raghu KalluriNat Rev Cancer201627550820No
81847582379.0126.7963.4Alzheimer's disease: the amyloid cascade hypothesis. J A Hardy, G A HigginsScience19921566067No
81923762376.060.0860.1Inferring the historical patterns of biological evolution. M PagelNature199910553904Yes
82023762376.049.6249.6Molecular physiology of P2X receptors. R Alan NorthPhysiol Rev200212270951No
82123762376.049.9249.9Cisplatin: mode of cytotoxic action and molecular basis of resistance. Zahid H SiddikOncogene200314576837No
82223732373.073.0973.1The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. B L FredricksonAm Psychol200111315248Yes
82347442372.0151.7175.9Microenvironmental regulation of tumor progression and metastasis. Daniela F Quail, Johanna A JoyceNat Med201324202395No
82447432371.548.7724.4Periodontal Disease In Pregnancy. I. Prevalence And Severity. H Loe, J SilnessActa Odontol Scand196314121956Yes
82523702370.082.3282.3Doxil®--the first FDA-approved nano-drug: lessons learned. Yechezkel BarenholzJ Control Release201222484195No
82647392369.5120.2460.1Management of hepatocellular carcinoma. Jordi Bruix, Morris ShermanHepatology200516250051No
82723692369.0107.83107.8Structural Model Evaluation and Modification: An Interval Estimation Approach. J H SteigerMultivariate Behav Res199026794479Yes
82823682368.054.0954.1A decade of molecular biology of retinoic acid receptors. P ChambonFASEB J19968801176No
82923682368.043.3843.4Java Treeview--extensible visualization of microarray data. Alok J SaldanhaBioinformatics200415180930Yes
83023672367.080.6680.7A rapid radiochemical method for the determination of choline acetyltransferase. F FonnumJ Neurochem19751113118Yes
83147332366.5140.8870.4Neural mechanisms of selective visual attention. R Desimone, J DuncanAnnu Rev Neurosci19957605061No
83247242362.0154.1177.1Random-effects models for longitudinal data. N M Laird, J H WareBiometrics19827168798Yes
83323622362.067.1867.2Scaffolds in tissue engineering bone and cartilage. D W HutmacherBiomaterials200011071603Yes
83447202360.0103.6651.8Death receptors: signaling and modulation. A Ashkenazi, V M DixitScience19989721089No
83523572357.0117.38117.4Electroimmuno assay. C B LaurellScand J Clin Lab Invest Suppl19724114358Yes
83623542354.057.2857.3The anatomy and taxonomy of protein structure. J S RichardsonAdv Protein Chem19817020376No
83723542354.075.9976.0Epidemiology of viral hepatitis and hepatocellular carcinoma. Hashem B El-SeragGastroenterology201222537432No
83823532353.0101.79101.8The Michigan alcoholism screening test: the quest for a new diagnostic instrument. M L SelzerAm J Psychiatry19715565851Yes
83923512351.051.8551.9Rab GTPases as coordinators of vesicle traffic. Harald StenmarkNat Rev Mol Cell Biol200919603039No
84023482348.043.2143.2Targeting RAS signalling pathways in cancer therapy. Julian DownwardNat Rev Cancer200312509763No
84146952347.5138.9569.5Missing data: our view of the state of the art. Joseph L Schafer, John W GrahamPsychol Methods200212090408Yes
84223462346.052.9553.0The inflammatory reflex. Kevin J TraceyNature200212490958No
84323452345.044.9845.0Mechanisms of type-I- and type-II-interferon-mediated signalling. Leonidas C PlataniasNat Rev Immunol200515864272No
84446892344.597.7448.9New functions for the matrix metalloproteinases in cancer progression. Mikala Egeblad, Zena WerbNat Rev Cancer200211990853No
84523442344.051.0151.0A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Douglas C WallaceAnnu Rev Genet200516285865No
84623432343.051.7151.7Mitochondrial diseases in man and mouse. D C WallaceScience199910066162No
84770292343.070.2623.4On The Nature Of Allosteric Transitions: A Plausible Model. J Monod, J Wyman, J P ChangeuxJ Mol Biol196514343300Yes
84823422342.051.8451.8The structure and regulation of protein phosphatases. P CohenAnnu Rev Biochem19892549856No
84923412341.077.977.9Working memory. A BaddeleyScience19921736359No
85046812340.5135.7967.9Nonparametric statistical testing of EEG- and MEG-data. Eric Maris, Robert OostenveldJ Neurosci Methods200717517438Yes
85170182339.3154.051.3The biology of VEGF and its receptors. Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouterNat Med200312778165No
85246742337.0103.251.6Screening lambdagt recombinant clones by hybridization to single plaques in situ. W D Benton, R W DavisScience1977322279Yes
85323332333.00.00.0Muscle structure and theories of contraction. A F HuxleyProg Biophys Biophys Chem195713485191Yes
85423332333.00.00.0Isolation by Distance. S WrightGenetics194317247074Yes
85546662333.0100.1450.1Judgment under Uncertainty: Heuristics and Biases. A Tversky, D KahnemanScience197417835457Yes
85623322332.084.3184.3Calmodulin plays a pivotal role in cellular regulation. W Y CheungScience19806243188No
85746582329.0126.7963.4Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. G Kresse, J HafnerPhys Rev B Condens Matter199410010505Yes
85846492324.587.2543.6A novel genetic system to detect protein-protein interactions. S Fields, O SongNature19892547163Yes
85923242324.061.0461.0A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. P ChomczynskiBiotechniques19937692896Yes
86046482324.0118.4759.2Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Marie-Christine Daniel, Didier AstrucChem Rev200414719978No
86146422321.0129.8164.9Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. R A Laskey, A D MillsEur J Biochem19751175627Yes
86223202320.046.5246.5Stereochemistry of cooperative effects in haemoglobin. M F PerutzNature19705528785Yes
86323192319.066.3266.3Interleukin-1 and interleukin-1 antagonism. C A DinarelloBlood19911826616No
86446382319.0131.1165.6The number of people with glaucoma worldwide in 2010 and 2020. H A Quigley, A T BromanBr J Ophthalmol200616488940Yes
86523182318.057.5657.6A model for receptor-regulated calcium entry. J W PutneyCell Calcium19862420465No
86646352317.5126.4963.2Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Michael D Fox, Marcus E RaichleNat Rev Neurosci200717704812No
86723162316.065.7665.8Inositol phospholipids and cell surface receptor function. R H MichellBiochim Biophys Acta1975164246No
86823162316.055.3255.3Ischemic cell death in brain neurons. P LiptonPhysiol Rev199910508238No
86946302315.0194.6897.3The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. H P Misra, I FridovichJ Biol Chem19724623845Yes
87069382312.7183.5261.2Regularization Paths for Generalized Linear Models via Coordinate Descent. Jerome Friedman, Trevor Hastie, Rob TibshiraniJ Stat Softw201020808728Yes
87123112311.090.0590.0Effective physician-patient communication and health outcomes: a review. M A StewartCMAJ19957728691Yes
87246212310.5160.3980.2The biofilm matrix. Hans-Curt Flemming, Jost WingenderNat Rev Microbiol201020676145No
87323072307.057.0657.1Bcl-2 and the regulation of programmed cell death. J C ReedJ Cell Biol19948294493No
87423062306.079.4579.5Gctf: Real-time CTF determination and correction. Kai ZhangJ Struct Biol201626592709Yes
87546102305.0121.9261.0Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. C W Elston, I O EllisHistopathology19911757079Yes
87646052302.5102.1851.1AKT/PKB signaling: navigating downstream. Brendan D Manning, Lewis C CantleyCell200717604717No
87723012301.048.6748.7NOX enzymes and the biology of reactive oxygen. J David LambethNat Rev Immunol200415039755No
87846002300.078.0339.0High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. M N Berry, D S FriendJ Cell Biol19694900611Yes
87945982299.074.1137.1On the size of the active site in proteases. I. Papain. I Schechter, A BergerBiochem Biophys Res Commun19676035483Yes
88045942297.0115.8657.9Acute-phase proteins and other systemic responses to inflammation. C Gabay, I KushnerN Engl J Med19999971870No
88122962296.071.5671.6Reactive oxygen species and the central nervous system. B HalliwellJ Neurochem19921402908No
88222932293.056.2656.3An index to quantify an individual's scientific research output. J E HirschProc Natl Acad Sci U S A200516275915Yes
88345792289.5116.1158.1A receptor-mediated pathway for cholesterol homeostasis. M S Brown, J L GoldsteinScience19863513311No
88422892289.019.3319.3Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. T HiguchiJ Pharm Sci196314088963Yes
88522872287.049.4649.5Nitric oxide and the immune response. C BogdanNat Immunol200111577346No
88622872287.058.1658.2Network pharmacology: the next paradigm in drug discovery. Andrew L HopkinsNat Chem Biol200818936753No
88722862286.045.2945.3SV40-transformed simian cells support the replication of early SV40 mutants. Y GluzmanCell19816260373Yes
88845722286.088.9744.5Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Yigong Shi, Joan MassaguéCell200312809600No
88922852285.056.3356.3Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. Jane GlazebrookAnnu Rev Phytopathol200516078883No
89022852285.061.8561.9Intestinal mucosal barrier function in health and disease. Jerrold R TurnerNat Rev Immunol200919855405No
89145692284.589.7444.9The interpretation of protein structures: estimation of static accessibility. B Lee, F M RichardsJ Mol Biol19715551392Yes
89222832283.078.4378.4Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. F F JöbsisScience1977929199Yes
89345642282.0167.6983.8Self-rated health and mortality: a review of twenty-seven community studies. E L Idler, Y BenyaminiJ Health Soc Behav19979097506No
89445642282.0107.4353.7Protein misfolding, functional amyloid, and human disease. Fabrizio Chiti, Christopher M DobsonAnnu Rev Biochem200616756495No
89522792279.093.9794.0The validity and practicality of sun-reactive skin types I through VI. T B FitzpatrickArch Dermatol19883377516Yes
89645572278.5166.9183.5The attention system of the human brain. M I Posner, S E PetersenAnnu Rev Neurosci19902183676No
89722772277.076.1776.2Glutamate, nitric oxide and cell-cell signalling in the nervous system. J GarthwaiteTrends Neurosci19911708538No
89822772277.00.00.0[Rapid physiological coagulation method in determination of fibrinogen]. A ClaussActa Haematol195713434757Yes
89922752275.069.1369.1A two process model of sleep regulation. A A BorbélyHum Neurobiol19827185792Yes
90091002275.0216.7454.2Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. C A Lipinski, F Lombardo, B W Dominy, P J FeeneyAdv Drug Deliv Rev200111259830No
90122732273.053.1153.1Specification of cerebral cortical areas. P RakicScience19883291116No
90222732273.049.249.2Chemokines and leukocyte traffic. M BaggioliniNature19989560152No
90345462273.0111.2255.6Nonparametric permutation tests for functional neuroimaging: a primer with examples. Thomas E Nichols, Andrew P HolmesHum Brain Mapp200211747097Yes
90422702270.042.8242.8Histone acetylation in chromatin structure and transcription. M GrunsteinNature19979311776No
90522692269.057.5657.6A theory of cortical responses. Karl FristonPhilos Trans R Soc Lond B Biol Sci200515937014No
90622692269.0104.56104.6Deep learning in neural networks: an overview. Jürgen SchmidhuberNeural Netw201525462637No
90722642264.071.071.0Human error: models and management. J ReasonBMJ200010720363Yes
90845282264.0121.9961.0Application of phylogenetic networks in evolutionary studies. Daniel H Huson, David BryantMol Biol Evol200616221896Yes
90922612261.047.2447.2Application of a microtechnique to viral serological investigations. J L SeverJ Immunol196213910995Yes
91022602260.060.0560.0The importance of selenium to human health. M P RaymanLancet200010963212No
91122592259.068.9168.9Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. R A DeFronzoDiabetes19883289989No
91222542254.058.2758.3The blood-brain barrier in health and chronic neurodegenerative disorders. Berislav V ZlokovicNeuron200818215617No
91390152253.8197.0249.3Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. A Krogh, B Larsson, G von Heijne, E L SonnhammerJ Mol Biol200111152613Yes
91445072253.594.9847.5Mass spectrometry-based proteomics. Ruedi Aebersold, Matthias MannNature200312634793No
91544982249.0102.8351.4A simple and very efficient method for generating cDNA libraries. U Gubler, B J HoffmanGene19836198242Yes
91622492249.044.3744.4The molecular biology of memory storage: a dialogue between genes and synapses. E R KandelScience200111691980No
91722472247.073.0573.0Eye movements in reading and information processing: 20 years of research. K RaynerPsychol Bull19989849112No
91822452245.061.5361.5Molecular diversity of glutamate receptors and implications for brain function. S NakanishiScience19921329206No
91922442244.049.1349.1Intracellular aspects of the process of protein synthesis. G PaladeScience19751096303No
92022442244.075.1575.2Simplified calculation of body-surface area. R D MostellerN Engl J Med19873657876Yes
92122442244.00.00.0Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. G BertaniJ Bacteriol195114888646Yes
92222432243.0109.27109.3Mechanisms of action of transmitters and other substances on smooth muscle. T B BoltonPhysiol Rev197937533No
92322422242.059.9259.9Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Claudiu T SupuranNat Rev Drug Discov200818167490No
92422402240.054.9454.9Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J Kyhse-AndersenJ Biochem Biophys Methods19846530509Yes
92522402240.053.0853.1Protein kinase C and lipid signaling for sustained cellular responses. Y NishizukaFASEB J19957737456No
92622402240.052.8452.8Mechanisms and genes of cellular suicide. H StellerScience19957878463No
92722392239.055.9355.9RGD and other recognition sequences for integrins. E RuoslahtiAnnu Rev Cell Dev Biol19968970741No
92822392239.058.7658.8MYC on the path to cancer. Chi V DangCell201222464321No
92922382238.083.683.6Specific impairments of planning. T ShallicePhilos Trans R Soc Lond B Biol Sci19826125971Yes
93022352235.077.5477.5Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. B N AmesScience19836351251No
93122342234.0123.0123.0Determination and quantification of content validity. M R LynnNurs Res19863640358Yes
93222342234.072.8672.9Qualitative research: standards, challenges, and guidelines. K MalterudLancet200111513933Yes
93322312231.070.7370.7Spinal and supraspinal factors in human muscle fatigue. S C GandeviaPhysiol Rev200111581501No
93422312231.053.5853.6Lead- and drug-like compounds: the rule-of-five revolution. Christopher A LipinskiDrug Discov Today Technol200424981612Yes
93544552227.5107.8553.9Regulation of the mevalonate pathway. J L Goldstein, M S BrownNature19901967820No
93644532226.5128.9964.5Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. C J Murray, A D LopezLancet19979167458Yes
93722262226.049.0449.0The regulation of AP-1 activity by mitogen-activated protein kinases. M KarinJ Biol Chem19957622446No
93844512225.598.1349.1Organization and expression of eucaryotic split genes coding for proteins. R Breathnach, P ChambonAnnu Rev Biochem19816791577No
93922252225.057.8257.8Working memory: looking back and looking forward. Alan BaddeleyNat Rev Neurosci200314523382No
94044482224.039.7619.9A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. J E TILL, E A McCULLOCHRadiat Res196113776896Yes
94144442222.087.9644.0Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. T V Bliss, T LomoJ Physiol19734727084Yes
94222212221.0536.14536.1Hallmarks of Cancer: New Dimensions. Douglas HanahanCancer Discov202235022204No
94322182218.068.568.5Biodiesel from microalgae. Yusuf ChistiBiotechnol Adv200717350212No
94422182218.063.5463.5TGFβ signalling in context. Joan MassaguéNat Rev Mol Cell Biol201222992590No
94544352217.591.245.6The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J A Spudich, S WattJ Biol Chem19714254541Yes
94622162216.053.9654.0Animal mitochondrial genomes. J L BooreNucleic Acids Res199910101183No
94722162216.058.2558.2Epidemiology of insomnia: what we know and what we still need to learn. Maurice M OhayonSleep Med Rev200212531146Yes
94844312215.5108.054.0A scaling normalization method for differential expression analysis of RNA-seq data. Mark D Robinson, Alicia OshlackGenome Biol201020196867Yes
949177152214.4559.269.9The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C SiebertN Engl J Med19938366922Yes
95022132213.0137.4137.4Presidential Address-1976. Social support as a moderator of life stress. S CobbPsychosom Med1976981490Yes
95122122212.068.0568.0Prooxidant states and tumor promotion. P A CeruttiScience19852981433No
95222122212.083.3583.3Role of endothelium in responses of vascular smooth muscle. R F FurchgottCirc Res19836313250No
95322112211.064.3264.3Hazards of heavy metal contamination. Lars JärupBr Med Bull200314757716No
95444212210.596.2848.1Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. F Sallusto, A LanzavecchiaJ Exp Med19948145033Yes
95544202210.099.2749.6The Bcl-2 protein family: arbiters of cell survival. J M Adams, S CoryScience19989735050No
95622092209.0112.74112.7The antibiotic resistance crisis: part 1: causes and threats. C Lee VentolaP T201525859123Yes
95722052205.065.4665.5Diagnosis of Alzheimer's disease. Z S KhachaturianArch Neurol19852864910Yes
95844022201.0119.4159.7A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Y Matsumura, H MaedaCancer Res19862946403Yes
95944012200.599.1449.6Brown adipose tissue: function and physiological significance. Barbara Cannon, Jan NedergaardPhysiol Rev200414715917No
96021992199.089.189.1Role of Streptococcus mutans in human dental decay. W J LoescheMicrobiol Rev19863540569No
96121982198.069.1169.1Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. W A CraigClin Infect Dis19989455502No
96221972197.057.5257.5Pancreatic cancer. Manuel HidalgoN Engl J Med201020427809No
96321952195.054.954.9Removal of fatty acids from serum albumin by charcoal treatment. R F ChenJ Biol Chem19676016603Yes
96421942194.061.8761.9Hybrid porous solids: past, present, future. Gérard FéreyChem Soc Rev200818197340Yes
96521922192.041.3641.4Shelterin: the protein complex that shapes and safeguards human telomeres. Titia de LangeGenes Dev200516166375No
96621912191.079.2179.2Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. H W SteinbuschNeuroscience19817017455Yes
96721912191.063.8263.8Social determinants of health inequalities. Michael MarmotLancet200515781105Yes
96843762188.0125.2962.6Distributed hierarchical processing in the primate cerebral cortex. D J Felleman, D C Van EssenCereb Cortex19911822724No
96921842184.055.6455.6Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. R D Pascual-MarquiMethods Find Exp Clin Pharmacol200212575463No
97021832183.048.4548.5Chemokines. B J RollinsBlood19979242519No
97121802180.065.2865.3PsychoPy--Psychophysics software in Python. Jonathan W PeirceJ Neurosci Methods200717254636Yes
97221792179.086.5486.5Approximate entropy as a measure of system complexity. S M PincusProc Natl Acad Sci U S A199111607165Yes
973196112179.0935.53103.9Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie BrayInt J Cancer201525220842Yes
97443562178.0111.2355.6Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. M Matsuda, R A DeFronzoDiabetes Care199910480510Yes
97521772177.046.4946.5Complement. First of two parts. M J WalportN Engl J Med200111287977No
97621762176.090.6390.6A systematic method for clinical description and classification of personality variants. A proposal. C R CloningerArch Gen Psychiatry19873579504Yes
97721742174.053.2253.2Breast cancer and hormone-replacement therapy in the Million Women Study. Valerie BeralLancet200312927427Yes
97865172172.3250.6383.5Glucose clamp technique: a method for quantifying insulin secretion and resistance. R A DeFronzo, J D Tobin, R AndresAm J Physiol1979382871Yes
97921722172.047.347.3The distribution of secondary growths in cancer of the breast. 1889. S PagetCancer Metastasis Rev19892673568No
98021692169.053.7353.7P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation. Berk HessJ Chem Theory Comput200826619985Yes
98121672167.065.7565.8Fetal origins of coronary heart disease. D J BarkerBMJ19957613432No
98221652165.071.5371.5A classification of glycosyl hydrolases based on amino acid sequence similarities. B HenrissatBiochem J19911747104Yes
98321652165.075.3175.3Large-scale brain networks and psychopathology: a unifying triple network model. Vinod MenonTrends Cogn Sci201121908230No
98421612161.041.8241.8Protein modules and signalling networks. T PawsonNature19957531822No
98521612161.058.6358.6Biofilms: microbial life on surfaces. Rodney M DonlanEmerg Infect Dis200212194761No
98686432160.8209.0752.3Matrix elasticity directs stem cell lineage specification. Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E DischerCell200616923388Yes
98721602160.060.0460.0Superoxide radical and superoxide dismutases. I FridovichAnnu Rev Biochem19957574505No
98821602160.069.6269.6Keratoconus. Y S RabinowitzSurv Ophthalmol19989493273No
98943192159.50.00.0Loss of recent memory after bilateral hippocampal lesions. W B Scoville, B MilnerJ Neurol Neurosurg Psychiatry195713406589Yes
99043172158.5104.5252.3Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Michael T Lin, M Flint BealNature200617051205No
99143162158.0148.0174.0Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. R B Devereux, N ReichekCirculation1977138494Yes
99221562156.047.9548.0A clearer vision for in vivo imaging. R WeisslederNat Biotechnol200111283581No
99321542154.058.3358.3The episodic buffer: a new component of working memory? A BaddeleyTrends Cogn Sci200011058819Yes
99421542154.031.0431.0Sedimentation Studies Of The Size And Shape Of Dna. F W StudierJ Mol Biol196514290352Yes
99564582152.7131.5843.9Immunochemical quantitation of antigens by single radial immunodiffusion. G Mancini, A O Carbonara, J F HeremansImmunochemistry19654956917Yes
99621512151.049.4549.5Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. G TrinchieriAnnu Rev Immunol19957612223No
99742982149.0111.7355.9ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. B Ravel, M NewvilleJ Synchrotron Radiat200515968136Yes
99842972148.581.2240.6Variations in pattern of pubertal changes in girls. W A Marshall, J M TannerArch Dis Child19695785179Yes
99921482148.048.948.9Pathways towards and away from Alzheimer's disease. Mark P MattsonNature200415295589No
100042942147.0100.850.4Assembly of asparagine-linked oligosaccharides. R Kornfeld, S KornfeldAnnu Rev Biochem19853896128No
100142922146.0123.5361.8Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. J S Beckman, W H KoppenolAm J Physiol19968944624No
100221452145.00.00.0Analysis of tissue and arterial blood temperatures in the resting human forearm. H H PennesJ Appl Physiol194818887578Yes
100342882144.0107.3953.7Function and activation of NF-kappa B in the immune system. P A Baeuerle, T HenkelAnnu Rev Immunol19948011280No
100421442144.054.1254.1The extracellular matrix: not just pretty fibrils. Richard O HynesScience200919965464No
100521412141.054.7554.8Descending control of pain. Mark J MillanProg Neurobiol200212034378No
100664232141.0191.1763.7The brain's default network: anatomy, function, and relevance to disease. Randy L Buckner, Jessica R Andrews-Hanna, Daniel L SchacterAnn N Y Acad Sci200818400922No
100721402140.055.8455.8The molecular pathology of Alzheimer's disease. D J SelkoeNeuron19911673054No
100821402140.061.2161.2The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. D E AtkinsonBiochemistry19684972613Yes
100942752137.5102.3351.2Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Hashem B El-Serag, K Lenhard RudolphGastroenterology200717570226No
101021372137.00.00.0A new specific color reaction of hexuronic acids. Z DischeJ Biol Chem194720281638Yes
101164082136.0184.9861.7Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. C E Murry, R B Jennings, K A ReimerCirculation19863769170Yes
101242702135.073.8836.9A Simplified Lead Citrate Stain For Use In Electron Microscopy. J H Venable, R CoggeshallJ Cell Biol196514287192Yes
101385242131.0173.1743.3WebLogo: a sequence logo generator. Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E BrennerGenome Res200415173120Yes
101463832127.7177.0459.0Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. F E Harrell, K L Lee, D B MarkStat Med19968668867No
101521272127.039.9239.9NK cell recognition. Lewis L LanierAnnu Rev Immunol200515771571No
101621232123.051.0451.0Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Edward V LoftusGastroenterology200415168363Yes
101721232123.060.0160.0Infrared spectroscopy of proteins. Andreas BarthBiochim Biophys Acta200717692815No
101863662122.0145.8348.6MOLMOL: a program for display and analysis of macromolecular structures. R Koradi, M Billeter, K WüthrichJ Mol Graph19968744573Yes
101942422121.0121.9161.0Angiogenic factors. J Folkman, M KlagsbrunScience19872432664No
102021202120.044.6244.6Mammalian G1 cyclins. C J SherrCell19938513492No
102121202120.052.4952.5Using circular dichroism spectra to estimate protein secondary structure. Norma J GreenfieldNat Protoc200617406547Yes
102242392119.580.5340.3The fundamental role of epigenetic events in cancer. Peter A Jones, Stephen B BaylinNat Rev Genet200212042769No
102321192119.042.4342.4Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Shimon SakaguchiNat Immunol200515785760No
102463542118.0285.7695.3Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. B N Ames, J Mccann, E YamasakiMutat Res1975768755Yes
102521162116.035.6935.7Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. D AminoffBiochem J196113860975Yes
102663472115.7197.9466.0Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. R L Spitzer, K Kroenke, J B WilliamsJAMA199910568646Yes
102721142114.047.7447.7Comparison of the predicted and observed secondary structure of T4 phage lysozyme. B W MatthewsBiochim Biophys Acta19751180967Yes
102842282114.0180.6290.3The Health Belief Model: a decade later. N K Janz, M H BeckerHealth Educ Q19846392204No
102921122112.063.9764.0The unbiased estimation of number and sizes of arbitrary particles using the disector. D C SterioJ Microsc19846737468Yes
103021122112.089.8189.8What's in a name? Qualitative description revisited. Margarete SandelowskiRes Nurs Health201020014004Yes
103163332111.0119.2839.8Control of regulatory T cell development by the transcription factor Foxp3. Shohei Hori, Takashi Nomura, Shimon SakaguchiScience200312522256Yes
103221082108.045.1345.1Theta oscillations in the hippocampus. György BuzsákiNeuron200211832222No
103342142107.0106.6853.3Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. E Lander, L KruglyakNat Genet19957581446Yes
103421072107.042.9643.0Role of angiogenesis in tumor growth and metastasis. Judah FolkmanSemin Oncol200212516034No
103563172105.7160.0553.4GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. R A Jefferson, T A Kavanagh, M W BevanEMBO J19873327686Yes
103621042104.054.3454.3The physiology of glucagon-like peptide 1. Jens Juul HolstPhysiol Rev200717928588No
1037126182103.0281.7947.0NMRPipe: a multidimensional spectral processing system based on UNIX pipes. F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A BaxJ Biomol NMR19958520220Yes
103842042102.0133.9367.0A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Gary J Bennett, Y-K XiePain19882837713Yes
103921012101.052.9553.0Accurate description of van der Waals complexes by density functional theory including empirical corrections. Stefan GrimmeJ Comput Chem200415224390Yes
104021012101.0103.72103.7Metazoan MicroRNAs. David P BartelCell201829570994No
104121002100.061.4661.5Hypoxia-inducible factors in physiology and medicine. Gregg L SemenzaCell201222304911No
104220992099.049.6449.6Patterns of amino acids near signal-sequence cleavage sites. G von HeijneEur J Biochem19836852022Yes
104320972097.038.238.2Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. P MitchellBiol Rev Camb Philos Soc19665329743No
104441932096.582.2741.1Network biology: understanding the cell's functional organization. Albert-László Barabási, Zoltán N OltvaiNat Rev Genet200414735121No
104520962096.0112.76112.8The assessment of clinical skills/competence/performance. G E MillerAcad Med19902400509Yes
104620962096.090.5790.6The Children's Depression, Inventory (CDI). M KovacsPsychopharmacol Bull19854089116Yes
104720952095.056.4656.5The plasma lecithins:cholesterol acyltransferase reaction. J A GlomsetJ Lipid Res19684868699No
104820922092.083.1583.2A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. E L BradleyArch Surg19938489394No
104941782089.082.2941.1Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Rik Derynck, Ying E ZhangNature200314534577No
105041772088.5110.2955.1The inflammasomes. Kate Schroder, Jurg TschoppCell201020303873No
105120882088.090.390.3Method For Assay Of Intestinal Disaccharidases. A DahlqvistAnal Biochem196414106916Yes
105241732086.5142.9971.5Shifting the genomic gold standard for the prokaryotic species definition. Michael Richter, Ramon Rosselló-MóraProc Natl Acad Sci U S A200919855009Yes
105320852085.045.7145.7Biology of natural killer cells. G TrinchieriAdv Immunol19892683611No
105420842084.063.8563.9Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Leonardo PantoniLancet Neurol201020610345No
105541602080.0101.4750.7Measuring the thickness of the human cerebral cortex from magnetic resonance images. B Fischl, A M DaleProc Natl Acad Sci U S A200010984517Yes
105641582079.0108.8454.4The heat-shock proteins. S Lindquist, E A CraigAnnu Rev Genet19882853609No
105720772077.0103.1103.1Abiotic Stress Signaling and Responses in Plants. Jian-Kang ZhuCell201627716505No
105862282076.0128.0742.7EMBOSS: the European Molecular Biology Open Software Suite. P Rice, I Longden, A BleasbyTrends Genet200010827456Yes
105920752075.074.1474.1International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. C HerrmannJ Psychosom Res19979055211No
106041462073.086.7543.4A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. G Shaw, R KamenCell19863488815Yes
106141452072.5100.5350.3Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. G G Glenner, C W WongBiochem Biophys Res Commun19846375662Yes
106241402070.082.0941.0Mammalian MAP kinase signalling cascades. L Chang, M KarinNature200111242034No
106362102070.0146.5748.9APE: Analyses of Phylogenetics and Evolution in R language. Emmanuel Paradis, Julien Claude, Korbinian StrimmerBioinformatics200414734327Yes
106420702070.050.2150.2Dopamine, learning and motivation. Roy A WiseNat Rev Neurosci200415152198No
106520692069.045.345.3Defensins: antimicrobial peptides of innate immunity. Tomas GanzNat Rev Immunol200312949495No
106620692069.038.038.0Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. J C SkouPhysiol Rev196514337569No
106741372068.536.4218.2Genetic regulatory mechanisms in the synthesis of proteins. F Jacob, J MonodJ Mol Biol196113718526Yes
106820682068.054.0554.0Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. J W LittlefieldScience196414168277Yes
106920672067.059.559.5ATP-regulated K+ channels in cardiac muscle. A NomaNature19836310409Yes
107020662066.042.4942.5G1 events and regulation of cell proliferation. A B PardeeScience19892683075No
107120662066.053.2353.2The heme oxygenase system: a regulator of second messenger gases. M D MainesAnnu Rev Pharmacol Toxicol19979131263No
107241302065.081.4540.7Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. M Gossen, H BujardProc Natl Acad Sci U S A19921319065Yes
107382552063.8303.2875.8Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanJ Clin Epidemiol200919631508No
107420632063.050.4850.5Drug-like properties and the causes of poor solubility and poor permeability. C A LipinskiJ Pharmacol Toxicol Methods200011274893No
107541192059.50.00.0Plaque formation and isolation of pure lines with poliomyelitis viruses. R Dulbecco, M VogtJ Exp Med195413130792Yes
107620582058.048.4648.5Interleukin-2: inception, impact, and implications. K A SmithScience19883131876No
107720562056.068.7168.7Purinergic nerves. G BurnstockPharmacol Rev19724404211No
107820532053.047.9447.9Metabolomics--the link between genotypes and phenotypes. Oliver FiehnPlant Mol Biol200211860207No
107920522052.067.0467.0Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. Peter C AustinPharm Stat201120925139Yes
108041012050.5110.9955.5New perspectives in cell adhesion: RGD and integrins. E Ruoslahti, M D PierschbacherScience19872821619No
108140952047.580.640.3Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Rudolf Jaenisch, Adrian BirdNat Genet200312610534No
108220472047.053.1753.2Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Gökhan S HotamisligilCell201020303879No
108320462046.013.4613.5The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. W W ClelandBiochim Biophys Acta196314021667Yes
108440842042.0183.4791.7Stages and processes of self-change of smoking: toward an integrative model of change. J O Prochaska, C C DiClementeJ Consult Clin Psychol19836863699Yes
108540832041.5100.6950.3Cutaneous wound healing. A J Singer, R A ClarkN Engl J Med199910471461No
108640812040.5173.8586.9The MOS social support survey. C D Sherbourne, A L StewartSoc Sci Med19912035047Yes
108720402040.041.3141.3Metastasis to bone: causes, consequences and therapeutic opportunities. Gregory R MundyNat Rev Cancer200212154351No
108820392039.051.1151.1Determination and analysis of urea and guanidine hydrochloride denaturation curves. C N PaceMethods Enzymol19863773761Yes
108920392039.058.3658.4Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. M LeavittMedGenMed200111549951No
109061092036.3182.3660.8Arlequin (version 3.0): an integrated software package for population genetics data analysis. Laurent Excoffier, Guillaume Laval, Stefan SchneiderEvol Bioinform Online200719325852Yes
109120362036.039.5939.6Signalling pathways of the TNF superfamily: a double-edged sword. Bharat B AggarwalNat Rev Immunol200312949498No
109240722036.0112.9256.5Autophagy: renovation of cells and tissues. Noboru Mizushima, Masaaki KomatsuCell201122078875No
109361062035.3201.0167.0Parallel organization of functionally segregated circuits linking basal ganglia and cortex. G E Alexander, M R DeLong, P L StrickAnnu Rev Neurosci19863085570No
109440702035.098.5449.3Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. P Liang, A B PardeeScience19921354393Yes
109520352035.072.4972.5Determination of glutathione and glutathione disulfide in biological samples. M E AndersonMethods Enzymol19854088074Yes
109620352035.047.7447.7Calcium signaling. D E ClaphamCell19957834745No
109720352035.050.4650.5Mechanisms of hepatic fibrogenesis. Scott L FriedmanGastroenterology200818471545No
109881382034.5174.9543.7MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi MiyataNucleic Acids Res200212136088Yes
109940672033.5124.6862.3Macrophage plasticity and polarization: in vivo veritas. Antonio Sica, Alberto MantovaniJ Clin Invest201222378047No
110081332033.2266.8966.7Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. A J Hughes, S E Daniel, L Kilford, A J LeesJ Neurol Neurosurg Psychiatry19921564476Yes
110120332033.041.9441.9Molecular bases for circadian clocks. J C DunlapCell19999988221No
110220322032.046.746.7Follicular helper CD4 T cells (TFH). Shane CrottyAnnu Rev Immunol201121314428No
110320312031.056.5156.5Estimating causal effects from large data sets using propensity scores. D B RubinAnn Intern Med19979382394No
110440572028.5129.6964.8Polymyositis and dermatomyositis (first of two parts). A Bohan, J B PeterN Engl J Med19751090839No
110520282028.044.3944.4Structural design and molecular evolution of a cytokine receptor superfamily. J F BazanProc Natl Acad Sci U S A19902169613Yes
110620282028.064.2864.3Health consequences of intimate partner violence. Jacquelyn C CampbellLancet200211965295No
110720242024.062.8562.9Ethical authorship and publishing. Andrew J S CoatsInt J Cardiol200919046787No
110840482024.0118.3259.2Wnt/β-catenin signaling and disease. Hans Clevers, Roel NusseCell201222682243No
110940452022.594.7447.4Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. B A Reynolds, S WeissScience19921553558Yes
111020212021.052.5452.5Analysis of bacteriophage T7 early RNAs and proteins on slab gels. F W StudierJ Mol Biol19734760132Yes
111120202020.058.4658.5Protein oxidation and aging. E R StadtmanScience19921355616No
111220202020.00.00.0Antigen-antibody reactions in gels. O OuchterlonyActa Pathol Microbiol Scand194918143039Yes
111340312015.579.3539.7The Wnt signaling pathway in development and disease. Catriona Y Logan, Roel NusseAnnu Rev Cell Dev Biol200415473860No
1114120852014.2379.6363.3Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell ParkinInt J Cancer201021351269Yes
111560392013.0186.4662.2Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. Aleksandr V Marenich, Christopher J Cramer, Donald G TruhlarJ Phys Chem B200919366259Yes
111660362012.0227.1875.7Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. G Muyzer, E C de Waal, A G UitterlindenAppl Environ Microbiol19937683183Yes
111720122012.039.039.0CpG motifs in bacterial DNA and their immune effects. Arthur M KriegAnnu Rev Immunol200211861616No
111860312010.3193.6764.6Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. C Lord, M Rutter, A Le CouteurJ Autism Dev Disord19947814313Yes
111920092009.035.0835.1ATM and related protein kinases: safeguarding genome integrity. Yosef ShilohNat Rev Cancer200312612651No
1120100452009.0235.1547.0Development and testing of a general amber force field. Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A CaseJ Comput Chem200415116359Yes
112120072007.041.6341.6XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. D E McReeJ Struct Biol199910222271Yes
112220032003.046.9246.9DAMPs, PAMPs and alarmins: all we need to know about danger. Marco E BianchiJ Leukoc Biol200717032697No
112340032001.50.00.0A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. R F Beers, I W SizerJ Biol Chem195214938361Yes
112420002000.078.3678.4Perception of risk. P SlovicScience19873563507Yes
112520002000.047.347.3Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Scott L FriedmanPhysiol Rev200818195085No
112639981999.0173.2586.6The Brief Symptom Inventory: an introductory report. L R Derogatis, N MelisaratosPsychol Med19836622612Yes
112739971998.5103.3251.7Building better batteries. M Armand, J-M TarasconNature200818256660No
112879921998.0380.2695.1The Satisfaction With Life Scale. E Diener, R A Emmons, R J Larsen, S GriffinJ Pers Assess198516367493Yes
112939961998.0107.6253.8The unfolded protein response: from stress pathway to homeostatic regulation. Peter Walter, David RonScience201122116877No
113039941997.096.6448.3Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. M Nei, T GojoboriMol Biol Evol19863444411Yes
113119961996.042.4942.5The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. U E LoeningBiochem J19675339944Yes
113219941994.036.5336.5In situ hybridization: an improved whole-mount method for Xenopus embryos. R M HarlandMethods Cell Biol19911811161Yes
113319911991.050.6950.7Flow-mediated endothelial mechanotransduction. P F DaviesPhysiol Rev19957624393No
113419911991.040.9741.0Mechanisms of intracellular protein transport. J E RothmanNature19947969419No
113519901990.082.7882.8A rating scale for drug-induced akathisia. T R BarnesBr J Psychiatry19892574607Yes
113659661988.7172.9857.7GSVA: gene set variation analysis for microarray and RNA-seq data. Sonja Hänzelmann, Robert Castelo, Justin GuinneyBMC Bioinformatics201323323831Yes
113739741987.086.0643.0The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. A J Ridley, A HallCell19921643657Yes
113839721986.0143.6671.8Deciphering key features in protein structures with the new ENDscript server. Xavier Robert, Patrice GouetNucleic Acids Res201424753421Yes
113939701985.085.2142.6Lessons from hereditary colorectal cancer. K W Kinzler, B VogelsteinCell19968861899No
114079371984.2297.5774.4The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. T F Heatherton, L T Kozlowski, R C Frecker, K O FagerströmBr J Addict19911932883Yes
114119841984.053.0253.0Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. J FolkmanN Engl J Med19957491141No
114219821982.095.1795.2Performance-oriented assessment of mobility problems in elderly patients. M E TinettiJ Am Geriatr Soc19863944402Yes
114319821982.072.2172.2UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. D W RussellJ Pers Assess19968576833Yes
114419821982.039.1639.2DNA topoisomerases: structure, function, and mechanism. J J ChampouxAnnu Rev Biochem200111395412No
114519821982.048.2548.2Interfaces and the driving force of hydrophobic assembly. David ChandlerNature200516193038No
114619811981.054.4354.4The biology of interleukin-6. T KishimotoBlood19892473791No
114719801980.038.2438.2Antiviral actions of interferons. C E SamuelClin Microbiol Rev200111585785No
114819801980.055.2755.3Japanese Classification of Gastric Carcinoma - 2nd English Edition - Japanese Gastric Cancer AssociationGastric Cancer199811957040Yes
114919771977.065.8865.9The use of a plus-maze to measure anxiety in the mouse. R G ListerPsychopharmacology (Berl)19873110839Yes
115019771977.020.5820.6Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? J V NeelAm J Hum Genet196213937884Yes
115139441972.097.6848.8Leptin and the regulation of body weight in mammals. J M Friedman, J L HalaasNature19989796811No
115239391969.589.8444.9The acute respiratory distress syndrome. L B Ware, M A MatthayN Engl J Med200010793167No
115339361968.090.1445.1Base-calling of automated sequencer traces using phred. II. Error probabilities. B Ewing, P GreenGenome Res19989521922Yes
115419681968.048.5948.6Negative refraction makes a perfect lens J B PendryPhys Rev Lett200011041972Yes
1155137711967.3304.0343.4Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank SpelemanGenome Biol200212184808Yes
115619671967.058.0758.1Intracellular calcium homeostasis. E CarafoliAnnu Rev Biochem19873304139No
115719671967.050.3650.4What is cognitive reserve? Theory and research application of the reserve concept. Yaakov SternJ Int Neuropsychol Soc200211939702No
115819671967.041.4641.5TRP channels as cellular sensors. David E ClaphamNature200314654832No
115919661966.041.6141.6Developmental regulation of the growth plate. Henry M KronenbergNature200312748651No
116019641964.086.3186.3A modified card sorting test sensitive to frontal lobe defects. H E NelsonCortex19761009768Yes
116119641964.035.0635.1Signaling--2000 and beyond. T HunterCell200010647936No
116219641964.058.7658.8Global epidemiology of oral and oropharyngeal cancer. Saman WarnakulasuriyaOral Oncol200918804401No
116339211960.596.6548.3Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. P J Barnes, M KarinN Engl J Med19979091804No
116439181959.0107.4253.7Insulin-like growth factors and their binding proteins: biological actions. J I Jones, D R ClemmonsEndocr Rev19957758431No
116519591959.055.0255.0Flavonoids as antioxidants. P G PiettaJ Nat Prod200010924197No
116619591959.042.7442.7Neutrophils and immunity: challenges and opportunities. Carl NathanNat Rev Immunol200616498448No
116739141957.074.5637.3SIFT: Predicting amino acid changes that affect protein function. Pauline C Ng, Steven HenikoffNucleic Acids Res200312824425Yes
116839121956.065.5132.8Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. I W McLean, P K NakaneJ Histochem Cytochem19744374474Yes
116919561956.00.00.0Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. M KunitzJ Gen Physiol194719873496Yes
117019541954.038.1138.1Approaching the asymptote? Evolution and revolution in immunology. C A JanewayCold Spring Harb Symp Quant Biol19892700931No
117119541954.090.7690.8The brain's default mode network. Marcus E RaichleAnnu Rev Neurosci201525938726No
117258611953.7120.7640.3Rapid and efficient site-specific mutagenesis without phenotypic selection. T A Kunkel, J D Roberts, R A ZakourMethods Enzymol19873323813Yes
117339051952.5123.4161.7Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. A C Chang, S N CohenJ Bacteriol1978149110Yes
117419511951.00.00.0The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. S V BoydenJ Exp Med195114803635Yes
117539011950.5109.1154.6Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. B J Marshall, J R WarrenLancet19846145023Yes
117619501950.079.579.5Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. A FleckensteinAnnu Rev Pharmacol Toxicol1977326161No
117719501950.058.8958.9Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? George A BonannoAm Psychol200414736317No
117819491949.060.2860.3Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. J P ChamberlainAnal Biochem1979543547Yes
117919481948.00.00.0On estimating the relation between blood group and disease. B WoolfAnn Hum Genet195514388528Yes
118077891947.2231.9758.0Antibiotic susceptibility testing by a standardized single disk method. A W Bauer, W M Kirby, J C Sherris, M TurckAm J Clin Pathol19665325707Yes
118119471947.069.2769.3The emerging role of lncRNAs in cancer. Maite HuarteNat Med201526540387No
118219461946.064.264.2Intermediate filaments as mechanical integrators of cellular space. E LazaridesNature19807188712Yes
118319461946.00.00.0Influences of glucose loading and of injected insulin on hepatic glucose output. R SteeleAnn N Y Acad Sci195913833973Yes
118419461946.038.6438.6DNA methylation and human disease. Keith D RobertsonNat Rev Genet200516136652No
118577831945.8323.6680.9jModelTest 2: more models, new heuristics and parallel computing. Diego Darriba, Guillermo L Taboada, Ramón Doallo, David PosadaNat Methods201222847109Yes
118658331944.3189.4963.2AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. P G Reeves, F H Nielsen, G C FaheyJ Nutr19938229312No
118719431943.040.9741.0The immunopathogenesis of sepsis. Jonathan CohenNature200212490963No
118819431943.0140.85140.8Obesity: global epidemiology and pathogenesis. Matthias BlüherNat Rev Endocrinol201930814686No
118919421942.037.7337.7Systems biology: a brief overview. Hiroaki KitanoScience200211872829No
119019411941.045.7745.8Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. A BreslowAnn Surg19705477666Yes
1191310461940.41012.9563.3Fiji: an open-source platform for biological-image analysis. Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert CardonaNat Methods201222743772Yes
119219401940.053.553.5Trail Making Test A and B: normative data stratified by age and education. Tom N TombaughArch Clin Neuropsychol200415010086Yes
119338771938.594.2347.1Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. J G Rheinwald, H GreenCell19751052771Yes
1194135681938.3311.1944.5Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya YamanakaCell200718035408Yes
119519371937.055.2955.3Excitotoxic cell death. D W ChoiJ Neurobiol19921361523No
119619361936.039.0539.0The complex language of chromatin regulation during transcription. Shelley L BergerNature200717522673No
119738711935.5132.5966.3Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. W R Morrison, L M SmithJ Lipid Res196414221106Yes
119877411935.2189.8347.5Cancer-related inflammation. Alberto Mantovani, Paola Allavena, Antonio Sica, Frances BalkwillNature200818650914No
119919351935.040.3740.4A cell culture model for T lymphocyte clonal anergy. R H SchwartzScience19902113314Yes
120058051935.0175.8358.6Estimating the mean and variance from the median, range, and the size of a sample. Stela Pudar Hozo, Benjamin Djulbegovic, Iztok HozoBMC Med Res Methodol200515840177Yes
120119351935.045.4745.5The global health burden of infection-associated cancers in the year 2002. Donald Maxwell ParkinInt J Cancer200616404738Yes
120258031934.3107.4735.8Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Jason D Fontenot, Marc A Gavin, Alexander Y RudenskyNat Immunol200312612578Yes
120319341934.057.3957.4Calbindin D-28k and parvalbumin in the rat nervous system. M R CelioNeuroscience19902199841Yes
120419331933.061.2361.2Calculation of substrate oxidation rates in vivo from gaseous exchange. K N FraynJ Appl Physiol Respir Environ Exerc Physiol19836618956Yes
120519321932.060.8460.8Sick individuals and sick populations. G RoseInt J Epidemiol19853872850Yes
120619321932.044.6644.7Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. B L WajchenbergEndocr Rev200011133069No
120719321932.00.00.0On respiratory impairment in cancer cells. O WarburgScience195613351639Yes
120838641932.087.9744.0Liver fibrosis. Ramón Bataller, David A BrennerJ Clin Invest200515690074No
120938641932.0114.4857.2Oncology meets immunology: the cancer-immunity cycle. Daniel S Chen, Ira MellmanImmunity201323890059No
121019311931.039.7539.8Thrombin signalling and protease-activated receptors. S R CoughlinNature200011001069No
121119311931.062.6262.6Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Sergio PecorelliInt J Gynaecol Obstet200919367689No
121238601930.0102.8951.4Inositol phosphates and cell signalling. M J Berridge, R F IrvineNature19892550825No
121338591929.585.1842.6Issues and challenges facing rechargeable lithium batteries. J M Tarascon, M ArmandNature200111713543Yes
121419291929.050.4750.5DNA topoisomerase poisons as antitumor drugs. L F LiuAnnu Rev Biochem19892549853No
121519291929.042.9242.9Signal sequences. The limits of variation. G von HeijneJ Mol Biol19854032478Yes
121619261926.060.6960.7Epidemiological features of chronic low-back pain. G B AnderssonLancet199910470716No
121738511925.586.143.0The DNA-damage response in human biology and disease. Stephen P Jackson, Jiri BartekNature200919847258No
121838491924.594.8947.4The endophenotype concept in psychiatry: etymology and strategic intentions. Irving I Gottesman, Todd D GouldAm J Psychiatry200312668349No
121938471923.5123.6261.8Oxygen toxicity, oxygen radicals, transition metals and disease. B Halliwell, J M GutteridgeBiochem J19846326753No
122019231923.033.8633.9Mechanisms of alternative pre-messenger RNA splicing. Douglas L BlackAnnu Rev Biochem200312626338No
122119221922.046.9446.9DNA topoisomerases. J C WangAnnu Rev Biochem19852992360No
122219221922.052.6552.6Determination of minimum inhibitory concentrations. J M AndrewsJ Antimicrob Chemother200111420333Yes
122338421921.073.6736.8Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. M Karin, Y Ben-NeriahAnnu Rev Immunol200010837071No
122419201920.038.9839.0The expanding role of mitochondria in apoptosis. X WangGenes Dev200111711427No
122519191919.046.5446.5Thioredoxin. A HolmgrenAnnu Rev Biochem19853896121No
122619171917.082.9482.9Brain dopamine receptors. P SeemanPharmacol Rev19806117090No
122719161916.033.8533.9The regulation of E2F by pRB-family proteins. N DysonGenes Dev19989694791No
122819141914.045.3445.3The dawning era of polymer therapeutics. Ruth DuncanNat Rev Drug Discov200312750738No
122976531913.2188.6947.2p53 mutations in human cancers. M Hollstein, D Sidransky, B Vogelstein, C C HarrisScience19911905840No
123019131913.036.5836.6Notch signalling: a simple pathway becomes complex. Sarah J BrayNat Rev Mol Cell Biol200616921404No
123138251912.5128.0464.0Mathematical model for studying genetic variation in terms of restriction endonucleases. M Nei, W H LiProc Natl Acad Sci U S A1979291943Yes
123219121912.040.8340.8The etiology of chondromalacia patellae. R E OuterbridgeJ Bone Joint Surg Br196114038135Yes
123338231911.50.00.0Acetylornithinase of Escherichia coli: partial purification and some properties. H J Vogel, D M BonnerJ Biol Chem195613278318Yes
123419111911.042.8842.9High-speed scanning in human memory. S SternbergScience19665939936Yes
123519111911.056.1256.1Inhibited spontaneous emission in solid-state physics and electronics. E YablonovitchPhys Rev Lett198710034639Yes
123619111911.053.9353.9Introduction and General Overview of Cyclodextrin Chemistry. József SzejtliChem Rev199811848947Yes
123776421910.5297.8174.5A simple technique for quantitation of low levels of DNA damage in individual cells. N P Singh, M T McCoy, R R Tice, E L SchneiderExp Cell Res19883345800Yes
123819101910.063.0163.0Physiological actions of taurine. R J HuxtablePhysiol Rev19921731369No
123919101910.059.8259.8A new automated colorimetric method for measuring total oxidant status. Ozcan ErelClin Biochem200516214125Yes
124019081908.039.1639.2Mechanisms of cancer drug resistance. Michael M GottesmanAnnu Rev Med200211818492No
124157181906.0187.7462.6Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. L Excoffier, P E Smouse, J M QuattroGenetics19921644282Yes
124219061906.046.1746.2Cancer chemoprevention with dietary phytochemicals. Young-Joon SurhNat Rev Cancer200314570043No
124319061906.061.0161.0Grounded cognition. Lawrence W BarsalouAnnu Rev Psychol200817705682No
124438111905.5119.2959.6Efficient pseudopotentials for plane-wave calculations. N Troullier, J L MartinsPhys Rev B Condens Matter19919997467Yes
124538101905.098.0849.0Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering S Nie, S R EmoryScience19979027306Yes
124619051905.041.3741.4A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. J SantaLuciaProc Natl Acad Sci U S A19989465037Yes
124719051905.049.0349.0Dengue and dengue hemorrhagic fever. D J GublerClin Microbiol Rev19989665979No
124838091904.588.1144.1PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. Alexander W Schüttelkopf, Daan M F van AaltenActa Crystallogr D Biol Crystallogr200415272157Yes
124919041904.062.3762.4The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. G S ManningQ Rev Biophys1978353876No
125019031903.046.2346.2Episodic memory: from mind to brain. Endel TulvingAnnu Rev Psychol200211752477Yes
125176111902.82319.67579.9Cancer statistics, 2022. Rebecca L Siegel, Kimberly D Miller, Hannah E Fuchs, Ahmedin JemalCA Cancer J Clin202235020204Yes
125219011901.054.3854.4The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. G P ChrousosN Engl J Med19957715646No
125357001900.0336.8112.3Research diagnostic criteria: rationale and reliability. R L Spitzer, J Endicott, E RobinsArch Gen Psychiatry1978655775Yes
125419001900.00.00.0The oxidation of ribonuclease with performic acid. C H HirsJ Biol Chem195613319283Yes
125537991899.5112.3156.2Mechanisms of salinity tolerance. Rana Munns, Mark TesterAnnu Rev Plant Biol200818444910No
125618991899.047.0347.0Pathogen recognition and inflammatory signaling in innate immune defenses. Trine H MogensenClin Microbiol Rev200919366914No
125718981898.053.9453.9In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. T R ChenExp Cell Res197765285Yes
125818971897.024.7224.7A theory of cerebellar cortex. D MarrJ Physiol19695784296Yes
125937871893.5134.8767.4ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. M Gardes, T D BrunsMol Ecol19938180733Yes
126018931893.069.869.8Pro-resolving lipid mediators are leads for resolution physiology. Charles N SerhanNature201424899309No
126118911891.041.0241.0The mitogen-activated protein kinase signal transduction pathway. R J DavisJ Biol Chem19938325833No
126237811890.586.4243.2The Fas death factor. S Nagata, P GolsteinScience19957533326No
126337801890.0112.0156.0Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. James J Gross, Oliver P JohnJ Pers Soc Psychol200312916575Yes
126418901890.043.2543.2Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Jeffrey A EngelmanNat Rev Cancer200919629070No
126537791889.588.7644.4Neuronal oscillations in cortical networks. György Buzsáki, Andreas DraguhnScience200415218136No
1266207801889.1519.1547.2PLINK: a tool set for whole-genome association and population-based linkage analyses. Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C ShamAm J Hum Genet200717701901Yes
126737771888.5132.9866.5Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. Sarvajeet Singh Gill, Narendra TutejaPlant Physiol Biochem201020870416No
126818881888.059.5259.5Complete nucleotide sequence of the Escherichia coli plasmid pBR322. J G SutcliffeCold Spring Harb Symp Quant Biol1979383387Yes
126937761888.084.9342.5Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. T Miyashita, J C ReedCell19957834749Yes
127018871887.017.517.5Positional information and the spatial pattern of cellular differentiation. L WolpertJ Theor Biol19694390734Yes
127137741887.0128.6564.3Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. M H Zweig, G CampbellClin Chem19938472349No
127218861886.045.5345.5Python: a programming language for software integration and development. M F SannerJ Mol Graph Model199910660911Yes
127337721886.084.0942.0Parkinson's disease: mechanisms and models. William Dauer, Serge PrzedborskiNeuron200312971891No
127437701885.0112.0956.0An efficient mRNA-dependent translation system from reticulocyte lysates. H R Pelham, R J JacksonEur J Biochem1976823012Yes
127518851885.059.1759.2Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Berislav V ZlokovicNat Rev Neurosci201122048062No
127637631881.589.6644.8The future of genetic studies of complex human diseases. N Risch, K MerikangasScience19968801636Yes
127718801880.045.2145.2The genetics of ageing. Cynthia J KenyonNature201020336132No
127818791879.00.00.0Dendritic organization in the neurons of the visual and motor cortices of the cat. D A ShollJ Anat195313117757Yes
127918791879.064.0264.0Guided Search 2.0 A revised model of visual search. J M WolfePsychon Bull Rev199424203471Yes
128056301876.7144.1448.0Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. G S Hotamisligil, N S Shargill, B M SpiegelmanScience19937678183Yes
128118761876.052.8952.9Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. A DunaifEndocr Rev19979408743No
128218761876.041.3241.3Cellular mechanisms of insulin resistance. G I ShulmanJ Clin Invest200010903330No
128337511875.5126.6263.3Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. G Di Chiara, A ImperatoProc Natl Acad Sci U S A19882899326Yes
128418751875.086.7686.8A simple fluorometric assay for lipoperoxide in blood plasma. K YagiBiochem Med1976962904Yes
128518751875.050.950.9A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. P J GoodfordJ Med Chem19853892003Yes
128618741874.069.2769.3Recognition-by-components: a theory of human image understanding. Irving BiedermanPsychol Rev19873575582Yes
128774921873.0251.9863.0Reporting results of cancer treatment. A B Miller, B Hoogstraten, M Staquet, A WinklerCancer19817459811Yes
128874811870.2184.3746.1Epithelial-mesenchymal transitions in development and disease. Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela NietoCell200919945376No
128918701870.041.7741.8The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Michael R LieberAnnu Rev Biochem201020192759No
129037381869.0105.8652.9Event-related EEG/MEG synchronization and desynchronization: basic principles. G Pfurtscheller, F H Lopes da SilvaClin Neurophysiol199910576479No
129156071869.0243.181.0Scoping studies: advancing the methodology. Danielle Levac, Heather Colquhoun, Kelly K O'BrienImplement Sci201020854677Yes
129237351867.579.1539.6Raster3D: photorealistic molecular graphics. E A Merritt, D J BaconMethods Enzymol199718488322Yes
129318671867.051.951.9Cell biology and molecular basis of denitrification. W G ZumftMicrobiol Mol Biol Rev19979409151No
129418671867.040.0140.0Exploring complex networks. S H StrogatzNature200111258382No
129537331866.5129.1264.6PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. Daniel R Roe, Thomas E CheathamJ Chem Theory Comput201326583988Yes
129618651865.053.4453.4Multiple imputation: a primer. J L SchaferStat Methods Med Res199910347857No
129755921864.0125.4241.8A new statistical method for haplotype reconstruction from population data. M Stephens, N J Smith, P DonnellyAm J Hum Genet200111254454Yes
129818641864.045.1445.1The hydrogen bond in the solid state. Thomas SteinerAngew Chem Int Ed Engl200212491444Yes
129918621862.068.1468.1Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. D R JaneroFree Radic Biol Med19902079232No
1300148901861.2364.3645.5Electric field effect in atomically thin carbon films. K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A FirsovScience200415499015Yes
1301111661861.0617.36102.9DADA2: High-resolution sample inference from Illumina amplicon data. Benjamin J Callahan, Paul J McMurdie, Michael J Rosen, Andrew W Han, Amy Jo A Johnson, Susan P HolmesNat Methods201627214047Yes
130237201860.067.9834.0Rho GTPases in cell biology. Sandrine Etienne-Manneville, Alan HallNature200212478284No
130318591859.041.6541.6Fabrication of novel biomaterials through molecular self-assembly. Shuguang ZhangNat Biotechnol200314520402No
130418581858.053.853.8Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. D M NevilleJ Biol Chem19715127429Yes
130518571857.048.5448.5Hepatitis B virus infection. W M LeeN Engl J Med19979392700No
130618561856.037.3237.3Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. R J KaufmanGenes Dev199910346810No
1307129881855.4463.7566.2Assessing the quality of reports of randomized clinical trials: is blinding necessary? A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuayControl Clin Trials19968721797Yes
130818541854.043.0243.0The retinal pigment epithelium in visual function. Olaf StraussPhysiol Rev200515987797No
130955581852.7138.8146.3Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Z N Oltvai, C L Milliman, S J KorsmeyerCell19938358790Yes
131037051852.576.6238.3Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. C D Nobes, A HallCell19957536630Yes
131118511851.0113.79113.8Understanding Bland Altman analysis. Davide GiavarinaBiochem Med (Zagreb)201526110027No
131236981849.0111.7655.9Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. R L Heath, L PackerArch Biochem Biophys19685655425Yes
131336971848.5116.3758.2Understanding interobserver agreement: the kappa statistic. Anthony J Viera, Joanne M GarrettFam Med200515883903Yes
131436951847.537.818.9Immunoassay of insulin with insulin-antibody precipitate. C N Hales, P J RandleBiochem J196313952078Yes
131518471847.046.6746.7Protein denaturation. C TanfordAdv Protein Chem19684882248No
131618471847.049.2749.3Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. Robert E MarxJ Oral Maxillofac Surg200312966493Yes
1317147681846.0415.652.0Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A ErlichScience19882448875Yes
131818461846.041.7841.8Integrating cell-signalling pathways with NF-kappaB and IKK function. Neil D PerkinsNat Rev Mol Cell Biol200717183360No
131918451845.041.4641.5Global cancer statistics in the year 2000. D M ParkinLancet Oncol200111905707No
132036901845.0112.5856.3Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Stephen M Smith, Thomas E NicholsNeuroimage200918501637Yes
132136891844.578.0239.0Monocyte and macrophage heterogeneity. Siamon Gordon, Philip R TaylorNat Rev Immunol200516322748No
132218431843.044.8344.8Evolutionary relationship of DNA sequences in finite populations. F TajimaGenetics19836628982Yes
132318431843.077.2277.2The drug abuse screening test. H A SkinnerAddict Behav19827183189Yes
132418421842.096.3296.3Subjective well-being. E DienerPsychol Bull19846399758No
132518421842.043.6643.7The mitochondrial permeability transition pore and its role in cell death. M CromptonBiochem J199910393078No
132655201840.0121.4240.5A rapid method for the isolation of functional thymus-derived murine lymphocytes. M H Julius, E Simpson, L A HerzenbergEur J Immunol19734587740Yes
132718401840.068.2568.2Physiological aspects of primary hypertension. B FolkowPhysiol Rev19826461865No
132818401840.041.6141.6DNA topoisomerases. J C WangAnnu Rev Biochem19968811192No
132973581839.5177.8844.5Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. A Shevchenko, M Wilm, O Vorm, M MannAnal Chem19968779443Yes
133073551838.8336.3284.1Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. D J Sahn, A DeMaria, J Kisslo, A WeymanCirculation1978709763Yes
133118381838.066.1966.2Why patients use alternative medicine: results of a national study. J A AstinJAMA19989605899Yes
133218381838.048.4748.5The comet assay for DNA damage and repair: principles, applications, and limitations. Andrew R CollinsMol Biotechnol200415004294No
133336751837.576.2538.1Identification of common molecular subsequences. T F Smith, M S WatermanJ Mol Biol19817265238Yes
133418351835.055.6455.6The atom economy--a search for synthetic efficiency. B M TrostScience19911962206Yes
133536691834.5109.8154.9Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). Kathryn M Connor, Jonathan R T DavidsonDepress Anxiety200312964174Yes
133636681834.0120.2860.1Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. R A DeFronzo, E FerranniniDiabetes Care19912044434No
133791691833.8219.3143.9Mapping and quantifying mammalian transcriptomes by RNA-Seq. Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara WoldNat Methods200818516045Yes
133818331833.057.6757.7The Gingival Index, the Plaque Index and the Retention Index Systems. H LöeJ Periodontol19675237684Yes
133918331833.037.2737.3The lasso method for variable selection in the Cox model. R TibshiraniStat Med19979044528Yes
134018331833.054.254.2An overview of brominated flame retardants in the environment. Cynthia A de WitChemosphere200211999784No
134154931831.0121.5540.5Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Michael W Pfaffl, Graham W Horgan, Leo DempfleNucleic Acids Res200211972351Yes
134218301830.045.0245.0Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Fiona TurnbullLancet200314615107Yes
134354821827.3249.3683.1Fast and sensitive protein alignment using DIAMOND. Benjamin Buchfink, Chao Xie, Daniel H HusonNat Methods201525402007Yes
134418271827.049.349.3A classification of hand preference by association analysis. M AnnettBr J Psychol19705457503Yes
134518271827.036.4636.5MicroRNA biogenesis: coordinated cropping and dicing. V Narry KimNat Rev Mol Cell Biol200515852042No
134618261826.048.348.3Molecular dissection of reactive astrogliosis and glial scar formation. Michael V SofroniewTrends Neurosci200919782411No
134736481824.0110.555.2New method for quantitative determination of uronic acids. N Blumenkrantz, G Asboe-HansenAnal Biochem19734269305Yes
134818241824.046.8346.8From sensation to cognition. M M MesulamBrain19989648540No
134918241824.012.8312.8A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. D A RobinsonIEEE Trans Biomed Eng196314121113Yes
135018241824.057.2857.3Matching methods for causal inference: A review and a look forward. Elizabeth A StuartStat Sci201020871802Yes
135136461823.081.440.7Amino acid substitution matrices from protein blocks. S Henikoff, J G HenikoffProc Natl Acad Sci U S A19921438297Yes
135236461823.076.1238.1Cell death: critical control points. Nika N Danial, Stanley J KorsmeyerCell200414744432No
135318221822.083.9584.0Determinants of low birth weight: methodological assessment and meta-analysis. M S KramerBull World Health Organ19873322602No
135418211821.035.4535.5Cancer and the chemokine network. Fran BalkwillNat Rev Cancer200415229479No
135518211821.050.0450.0Systemic lupus erythematosus. George C TsokosN Engl J Med201122129255No
135636371818.5131.4165.7miRBase: annotating high confidence microRNAs using deep sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201424275495Yes
135718171817.00.00.0The influence of some cations on an adenosine triphosphatase from peripheral nerves. J C SkouBiochim Biophys Acta195713412736Yes
135818171817.059.2759.3Cognitive reserve. Yaakov SternNeuropsychologia200919467352No
135918161816.069.8569.8Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. H U WittchenJ Psychiatr Res19948064641No
136036311815.598.849.4Biofilms: survival mechanisms of clinically relevant microorganisms. Rodney M Donlan, J William CostertonClin Microbiol Rev200211932229No
136118151815.036.4836.5Evolutionary rate at the molecular level. M KimuraNature19685637732Yes
136254421814.0194.9565.0Molecular mechanisms of epithelial-mesenchymal transition. Samy Lamouille, Jian Xu, Rik DerynckNat Rev Mol Cell Biol201424556840No
136336281814.0127.1863.6Regulation of microRNA biogenesis. Minju Ha, V Narry KimNat Rev Mol Cell Biol201425027649No
136418131813.036.736.7Molecular regulation of vessel maturation. Rakesh K JainNat Med200312778167No
136536261813.0307.53153.8The biology, function, and biomedical applications of exosomes. Raghu Kalluri, Valerie S LeBleuScience202032029601No
136654371812.3161.9354.0Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Helga Thorvaldsdóttir, James T Robinson, Jill P MesirovBrief Bioinform201322517427Yes
136718101810.059.0159.0Heavy metal intensification of DAB-based HRP reaction product. J C AdamsJ Histochem Cytochem19817252134Yes
136854291809.7481.08160.4An interactive web-based dashboard to track COVID-19 in real time. Ensheng Dong, Hongru Du, Lauren GardnerLancet Infect Dis202032087114Yes
136936151807.596.448.2Variations in the pattern of pubertal changes in boys. W A Marshall, J M TannerArch Dis Child19705440182Yes
137018071807.070.6770.7Predicting basal metabolic rate, new standards and review of previous work. W N SchofieldHum Nutr Clin Nutr19854044297Yes
137118061806.057.3557.4Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. U UngerstedtActa Physiol Scand Suppl19714332693Yes
137218051805.048.5448.5New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. R Y TsienBiochemistry19806770893Yes
137336091804.592.1346.1Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. K D McCarthy, J de VellisJ Cell Biol19806248568Yes
137454121804.0102.7734.3Surfing the p53 network. B Vogelstein, D Lane, A J LevineNature200011099028No
137518041804.018.6318.6Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. S CohenJ Biol Chem196213880319Yes
137618031803.049.1149.1Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. H LeVineProtein Sci19938453378Yes
137718011801.066.0166.0The Resonating Valence Bond State in La2CuO4 and Superconductivity. P W AndersonScience198717818979Yes
137836011800.5104.6752.3Molecular mechanisms and clinical applications of angiogenesis. Peter Carmeliet, Rakesh K JainNature201121593862No
137918001800.039.4939.5Gene finding in novel genomes. Ian KorfBMC Bioinformatics200415144565Yes
138017981798.00.00.0Cognitive maps in rats and men. E C TolmanPsychol Rev194818870876Yes
138171911797.8174.5943.6Improved optimization for the robust and accurate linear registration and motion correction of brain images. Mark Jenkinson, Peter Bannister, Michael Brady, Stephen SmithNeuroimage200212377157Yes
138235941797.086.2543.1Protein folding in the cell. M J Gething, J SambrookNature19921731198No
138317951795.056.4956.5Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. M ZasloffProc Natl Acad Sci U S A19873299384Yes
138435881794.0159.6579.8Multiple receptors for dopamine. J W Kebabian, D B CalneNature1979215920No
138517941794.098.2798.3Estimability and estimation in case-referent studies. O MiettinenAm J Epidemiol19761251836Yes
138617931793.062.5462.5A cortical network for directed attention and unilateral neglect. M M MesulamAnn Neurol19817032417No
138717931793.042.4842.5Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. D LavanchyJ Viral Hepat200414996343No
138817921792.051.3751.4Perceptual symbol systems. L W BarsalouBehav Brain Sci199911301525No
138935841792.087.0943.5Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Christian Haass, Dennis J SelkoeNat Rev Mol Cell Biol200717245412No
139017911791.035.8835.9The effect of infections on susceptibility to autoimmune and allergic diseases. Jean-Francois BachN Engl J Med200212239261No
139117911791.00.00.0The measurement of volume changes in human limbs. R J WhitneyJ Physiol195313085295Yes
139217911791.039.5939.6Recognition of microorganisms and activation of the immune response. Ruslan MedzhitovNature200717943118No
139317891789.042.2742.3Type III protein secretion systems in bacterial pathogens of animals and plants. C J HueckMicrobiol Mol Biol Rev19989618447No
139417891789.067.3267.3Cognitive reserve in ageing and Alzheimer's disease. Yaakov SternLancet Neurol201223079557No
139589391787.8234.3646.9Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary KingDiabetes Care200415111519Yes
139635741787.099.1449.6EQ-5D: a measure of health status from the EuroQol Group. R Rabin, F de CharroAnn Med200111491192No
139717871787.043.2243.2Integration, scaling, space-group assignment and post-refinement. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124693Yes
139817861786.049.049.0Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Ralph A DefronzoDiabetes200919336687No
1399107141785.7313.4252.2Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939837Yes
140035711785.594.147.0Receptive fields and functional architecture of monkey striate cortex. D H Hubel, T N WieselJ Physiol19684966457Yes
140135681784.0177.8188.9Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. M Mihara, M UchiyamaAnal Biochem1978655387Yes
140217841784.036.6136.6Structure and regulation of voltage-gated Ca2+ channels. W A CatterallAnnu Rev Cell Dev Biol200011031246No
140317831783.0116.3116.3Toward understanding the origin and evolution of cellular organisms. Minoru KanehisaProtein Sci201931441146No
140417821782.058.4358.4The crisis in antibiotic resistance. H C NeuScience19921509257No
140535631781.588.5344.3Maturation of the head of bacteriophage T4. I. DNA packaging events. U K Laemmli, M FavreJ Mol Biol19734204102Yes
140653431781.0160.2553.4Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. P A Wolf, R D Abbott, W B KannelStroke19911866765Yes
140717801780.047.0547.0Interleukin-6: an overview. J Van SnickAnnu Rev Immunol19902188664No
140817791779.058.7758.8Large-scale neurocognitive networks and distributed processing for attention, language, and memory. M M MesulamAnn Neurol19902260847No
140971101777.5197.6849.4Comorbidity measures for use with administrative data. A Elixhauser, C Steiner, D R Harris, R M CoffeyMed Care19989431328Yes
141053301776.7111.3637.1A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J H Zhang, T D Chung, K R OldenburgJ Biomol Screen199910838414Yes
141117761776.035.9435.9Points of control in inflammation. Carl NathanNature200212490957No
141217751775.032.8332.8Cellular roles of DNA topoisomerases: a molecular perspective. James C WangNat Rev Mol Cell Biol200212042765No
141317741774.048.4848.5Leptospirosis. P N LevettClin Microbiol Rev200111292640No
141417731773.058.8458.8Drugs of abuse: anatomy, pharmacology and function of reward pathways. G F KoobTrends Pharmacol Sci19921604710No
141517731773.057.7557.8Pineal melatonin: cell biology of its synthesis and of its physiological interactions. R J ReiterEndocr Rev19911649044No
141617731773.049.3349.3Porous scaffold design for tissue engineering. Scott J HollisterNat Mater200516003400No
141717721772.043.6243.6Adipose tissue, adipokines, and inflammation. Giamila FantuzziJ Allergy Clin Immunol200515867843No
141817691769.053.9253.9Social relationships and health. Sheldon CohenAm Psychol200415554821No
141917661766.057.3857.4The inverse care law. J T HartLancet19714100731Yes
142035321766.088.4944.2The biology of vascular endothelial growth factor. N Ferrara, T Davis-SmythEndocr Rev19979034784No
142117651765.047.8747.9G proteins and dual control of adenylate cyclase. A G GilmanCell19846321035Yes
142235271763.5128.1464.1The need to belong: desire for interpersonal attachments as a fundamental human motivation. R F Baumeister, M R LearyPsychol Bull19957777651No
142317631763.037.7337.7Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. J N DumontJ Morphol19724109871Yes
142470521763.0137.6234.4Stem cells, cancer, and cancer stem cells. T Reya, S J Morrison, M F Clarke, I L WeissmanNature200111689955No
142517621762.036.0536.0An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. R M EsnoufJ Mol Graph Model19979385560Yes
142617621762.00.00.0The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. S HestrinJ Biol Chem194918133390Yes
142717611761.042.4742.5Growth of the plant cell wall. Daniel J CosgroveNat Rev Mol Cell Biol200516261190No
142817611761.047.3547.4What we can do and what we cannot do with fMRI. Nikos K LogothetisNature200818548064No
142917601760.044.8244.8The pathophysiology of tumor necrosis factors. P VassalliAnnu Rev Immunol19921590993No
143017601760.040.1140.1Steroid receptor regulated transcription of specific genes and gene networks. K R YamamotoAnnu Rev Genet19853909942No
143117601760.0108.49108.5Making sense of implementation theories, models and frameworks. Per NilsenImplement Sci201525895742Yes
143217591759.00.00.0A personality scale of manifest anxiety. J A TaylorJ Abnorm Psychol195313052352Yes
143317591759.046.3846.4Oxidative stress and neurodegeneration: where are we now? Barry HalliwellJ Neurochem200616805774No
143417581758.061.0761.1The role of hormone receptors and GTP-regulatory proteins in membrane transduction. M RodbellNature19806101906Yes
143517581758.049.1649.2Oxidative stress: oxidants and antioxidants. H SiesExp Physiol19979129943No
143652741758.0139.046.3Median-joining networks for inferring intraspecific phylogenies. H J Bandelt, P Forster, A RöhlMol Biol Evol199910331250Yes
1437175731757.3549.9155.0Measurement of protein using bicinchoninic acid. P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C KlenkAnal Biochem19853843705Yes
143817571757.048.8148.8Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. M J CasadabanJ Mol Biol1976781293Yes
143935121756.086.5743.3Matrix metalloproteinases. H Nagase, J F WoessnerJ Biol Chem199910419448No
144017551755.018.6118.6Chromatin structure: a repeating unit of histones and DNA. R D KornbergScience19744825889Yes
144135081754.0108.554.2Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. F Denizot, R LangJ Immunol Methods19863486233Yes
144235081754.0136.5768.3Assays of glutathione peroxidase. L Flohé, W A GünzlerMethods Enzymol19846727659Yes
144317541754.035.8935.9Protein homology detection by HMM-HMM comparison. Johannes SödingBioinformatics200515531603Yes
144435071753.549.0324.5A complementation analysis of the restriction and modification of DNA in Escherichia coli. H W Boyer, D Roulland-DussoixJ Mol Biol19694896022Yes
144535071753.590.3245.2Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. M A Nitsche, W PaulusJ Physiol200010990547Yes
144617531753.038.8138.8The synaptic vesicle cycle: a cascade of protein-protein interactions. T C SüdhofNature19957791897No
144717521752.040.6440.6Areas, volumes, packing and protein structure. F M RichardsAnnu Rev Biophys Bioeng1977326146No
144852561752.0139.1346.4The metabolic syndrome--a new worldwide definition. K George M M Alberti, Paul Zimmet, Jonathan ShawLancet200516182882Yes
144917511751.043.6643.7Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. B Winkel-ShirleyPlant Physiol200111402179No
1450122521750.3296.5642.4Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M NathanN Engl J Med200211832527Yes
145117501750.036.4436.4Excitatory actions of gaba during development: the nature of the nurture. Yehezkel Ben-AriNat Rev Neurosci200212209121No
145217501750.046.046.0Chlorpromazine equivalent doses for the newer atypical antipsychotics. Scott W WoodsJ Clin Psychiatry200312823080No
145370001750.0270.367.6Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanInt J Surg201020171303No
145417491749.055.0355.0The stress response in fish. S E Wendelaar BongaPhysiol Rev19979234959No
145569951748.8382.1895.5fastp: an ultra-fast all-in-one FASTQ preprocessor. Shifu Chen, Yanqing Zhou, Yaru Chen, Jia GuBioinformatics201830423086Yes
145634961748.092.7146.4Prediction of protein antigenic determinants from amino acid sequences. T P Hopp, K R WoodsProc Natl Acad Sci U S A19816167991Yes
145734961748.0125.462.7Pain assessment: global use of the Brief Pain Inventory. C S Cleeland, K M RyanAnn Acad Med Singap19948080219No
145834951747.5138.569.2ROS function in redox signaling and oxidative stress. Michael Schieber, Navdeep S ChandelCurr Biol201424845678No
145917461746.044.0144.0Hydrogels for biomedical applications. Allan S HoffmanAdv Drug Deliv Rev200211755703No
146017461746.038.5138.5The hippo signaling pathway in development and cancer. Duojia PanDev Cell201020951342No
146117451745.057.257.2Serum albumin. T PetersAdv Protein Chem19853904348No
146234891744.574.2837.1Insulin signalling and the regulation of glucose and lipid metabolism. A R Saltiel, C R KahnNature200111742412Yes
146317441744.033.5433.5Transplacental carcinogenesis by stilbestrol. J FolkmanN Engl J Med19715556579Yes
146417441744.042.1342.1Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Paul M RidkerCirculation200312551853No
146517431743.041.941.9Why genes in pieces? W GilbertNature1978622185Yes
146617431743.037.7337.7ATPase activity of myosin correlated with speed of muscle shortening. M BárányJ Gen Physiol19674227924Yes
146734861743.072.9936.5Why do cancers have high aerobic glycolysis? Robert A Gatenby, Robert J GilliesNat Rev Cancer200415516961No
146817421742.071.5871.6Dynamic properties of mammalian skeletal muscles. R I ClosePhysiol Rev19724256989No
146917421742.054.4854.5Glutamate: a neurotransmitter in mammalian brain. F FonnumJ Neurochem19846139418No
147034821741.094.6847.3Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. K B Mullis, F A FaloonaMethods Enzymol19873431465Yes
147117401740.046.9346.9Oxidative stress hypothesis in Alzheimer's disease. W R MarkesberyFree Radic Biol Med19979165306No
147234801740.096.9248.5The precuneus: a review of its functional anatomy and behavioural correlates. Andrea E Cavanna, Michael R TrimbleBrain200616399806No
147334791739.585.2542.6Macrophage diversity enhances tumor progression and metastasis. Bin-Zhi Qian, Jeffrey W PollardCell201020371344No
147434771738.573.0736.5Integrin signaling. F G Giancotti, E RuoslahtiScience199910446041No
147517381738.061.8561.9Cyclosporine. B D KahanN Engl J Med19892687689No
147634721736.0122.4861.2The transtheoretical model of health behavior change. J O Prochaska, W F VelicerAm J Health Promot199710170434No
147717361736.058.758.7Functional and effective connectivity: a review. Karl J FristonBrain Connect201122432952No
147834711735.592.1446.1The mirror-neuron system. Giacomo Rizzolatti, Laila CraigheroAnnu Rev Neurosci200415217330No
147934711735.5148.4874.2mTOR Signaling in Growth, Metabolism, and Disease. Robert A Saxton, David M SabatiniCell201728283069No
148017351735.040.6840.7Solvent-accessible surfaces of proteins and nucleic acids. M L ConnollyScience19836879170Yes
148169391734.8135.5733.9Transformation of intact yeast cells treated with alkali cations. H Ito, Y Fukuda, K Murata, A KimuraJ Bacteriol19836336730Yes
148234691734.5113.7156.9Saliency, switching, attention and control: a network model of insula function. Vinod Menon, Lucina Q UddinBrain Struct Funct201020512370No
148334681734.091.0245.5Cloned glutamate receptors. M Hollmann, S HeinemannAnnu Rev Neurosci19948210177No
148452001733.3112.6537.6Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. A Nicholls, K A Sharp, B HonigProteins19911758883Yes
148517331733.031.4231.4CD4+ CD25+ suppressor T cells: more questions than answers. Ethan M ShevachNat Rev Immunol200212093005No
148617321732.040.840.8Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. A KrishanJ Cell Biol197549354Yes
148717321732.064.764.7Simple proton spectroscopic imaging. W T DixonRadiology19846089263Yes
148817311731.035.4335.4Oxidative stress shortens telomeres. Thomas von ZglinickiTrends Biochem Sci200212114022Yes
148917301730.038.2838.3Mode of cell migration to the superficial layers of fetal monkey neocortex. P RakicJ Comp Neurol19724624784Yes
149017301730.074.3574.3Optical properties of biological tissues: a review. Steven L JacquesPhys Med Biol201323666068No
149117291729.059.459.4Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? B HalliwellLancet19947915779No
149217291729.036.436.4Maintenance of C. elegans. Theresa StiernagleWormBook200618050451No
149334571728.5118.9259.5The Oswestry Disability Index. J C Fairbank, P B PynsentSpine (Phila Pa 1976)200011074683No
149434571728.599.4449.7Alzheimer's disease. Henry W Querfurth, Frank M LaFerlaN Engl J Med201020107219No
149517281728.065.465.4Antibiotics in the aquatic environment--a review--part I. Klaus KümmererChemosphere200919185900No
149651831727.7140.5746.9trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. Salvador Capella-Gutiérrez, José M Silla-Martínez, Toni GabaldónBioinformatics200919505945Yes
149734551727.579.8539.9The incidence of congenital heart disease. Julien I E Hoffman, Samuel KaplanJ Am Coll Cardiol200212084585No
149817271727.060.6860.7Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. M Wong-RileyBrain Res1979223730Yes
149917271727.037.537.5Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. A F HabeebAnal Biochem19664161471Yes
150017271727.00.00.0The recurrence of intracranial meningiomas after surgical treatment. D SimpsonJ Neurol Neurosurg Psychiatry195713406590Yes
150117271727.0118.98119.0High-performance medicine: the convergence of human and artificial intelligence. Eric J TopolNat Med201930617339No
150234521726.082.541.2Origins and Mechanisms of miRNAs and siRNAs. Richard W Carthew, Erik J SontheimerCell200919239886No
150317251725.049.7749.8Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. E M WassermannElectroencephalogr Clin Neurophysiol19989474057No
150434501725.078.7539.4Shared principles in NF-kappaB signaling. Matthew S Hayden, Sankar GhoshCell200818267068No
150517231723.059.5959.6Falls in older people: epidemiology, risk factors and strategies for prevention. Laurence Z RubensteinAge Ageing200616926202No
150651671722.3117.0439.0Inflammation and atherosclerosis. Peter Libby, Paul M Ridker, Attilio MaseriCirculation200211877368No
150717221722.00.00.0The general adaptation syndrome and the diseases of adaptation. H SelyeJ Clin Endocrinol Metab194621025115Yes
150817211721.056.2256.2Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. E M WitkinBacteriol Rev1976795416No
150934421721.0176.8388.4Interrater reliability of a modified Ashworth scale of muscle spasticity. R W Bohannon, M B SmithPhys Ther19873809245Yes
151017211721.042.7742.8Cellular basis of working memory. P S Goldman-RakicNeuron19957695894No
151151611720.3229.8176.6Some statistical methods useful in circulation research. S Wallenstein, C L Zucker, J L FleissCirc Res19807379260Yes
151234401720.0108.9854.5Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Jennifer A Doudna, Emmanuelle CharpentierScience201425430774No
151317191719.043.7843.8The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. R RossJ Cell Biol19714327464Yes
151417191719.052.1152.1Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. F RoussetGenetics19979093870Yes
151517191719.051.7251.7Aging, cellular senescence, and cancer. Judith CampisiAnnu Rev Physiol201323140366No
151617181718.033.3633.4Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Judith CampisiCell200515734683No
151734341717.0124.8762.4The integrative review: updated methodology. Robin Whittemore, Kathleen KnaflJ Adv Nurs200516268861Yes
151817161716.064.5664.6Modeling and variable selection in epidemiologic analysis. S GreenlandAm J Public Health19892916724Yes
1519102941715.7312.4952.1New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier GascuelSyst Biol201020525638Yes
152017141714.056.9356.9Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. C E MogensenN Engl J Med19846690964Yes
152151411713.7161.1353.7Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. H Esterbauer, R J Schaur, H ZollnerFree Radic Biol Med19911937131No
152234271713.50.00.0Convergent and discriminant validation by the multitrait-multimethod matrix. D T Campbell, D W FiskePsychol Bull195913634291Yes
152334271713.587.0243.5Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. Steven E Nissen, Kathy WolskiN Engl J Med200717517853Yes
152417131713.044.5844.6Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. G C WalkerMicrobiol Rev19846371470No
152534251712.583.1241.6The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. A E Bolton, W M HunterBiochem J19734733239Yes
152634231711.586.4943.2Quantum dot bioconjugates for ultrasensitive nonisotopic detection. W C Chan, S NieScience19989748158Yes
152717111711.040.3840.4The relationship between the spleen colony-forming cell and the haemopoietic stem cell. R SchofieldBlood Cells1978747780Yes
152817111711.040.8940.9Tricine-SDS-PAGE. Hermann SchäggerNat Protoc200617406207Yes
152917111711.039.0539.0Tumor angiogenesis. Robert S KerbelN Engl J Med200818463380No
153034201710.0146.9273.5A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. J G Snodgrass, M VanderwartJ Exp Psychol Hum Learn19807373248Yes
153134201710.0111.9956.0A "Direct-Coloring" Thiocholine Method For Cholinesterases. M J Karnovsky, L RootsJ Histochem Cytochem196414187330Yes
153268371709.2448.97112.2Rayyan-a web and mobile app for systematic reviews. Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz, Ahmed ElmagarmidSyst Rev201627919275Yes
153317091709.031.6331.6How eukaryotic transcriptional activators work. M PtashneNature19883050531No
153417091709.038.5638.6Effects of cytochalasin and phalloidin on actin. J A CooperJ Cell Biol19873312229No
153517091709.00.00.0Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. J SpizizenProc Natl Acad Sci U S A195816590310Yes
153617091709.032.3832.4Network motifs: theory and experimental approaches. Uri AlonNat Rev Genet200717510665No
153734101705.0145.472.7A fluorometric method for determination of oxidized and reduced glutathione in tissues. P J Hissin, R HilfAnal Biochem1976962076Yes
153817051705.060.8460.8Computerized transverse axial scanning (tomography). 1. Description of system. G N HounsfieldBr J Radiol19734757352Yes
153934081704.0151.976.0Cancer immunotherapy using checkpoint blockade. Antoni Ribas, Jedd D WolchokScience201829567705No
154034071703.5129.664.8The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. A J Stunkard, S MessickJ Psychosom Res19853981480Yes
154168141703.5143.8136.0Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. E A Jaffe, R L Nachman, C G Becker, C R MinickJ Clin Invest19734355998Yes
154217031703.052.1252.1A measure of population subdivision based on microsatellite allele frequencies. M SlatkinGenetics19957705646Yes
154317021702.041.4541.5Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. Z YangJ Mol Evol19947932792Yes
154434041702.073.5136.8Fibroblasts in cancer. Raghu Kalluri, Michael ZeisbergNat Rev Cancer200616572188No
154517021702.057.1157.1Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. Lutz AckermannChem Rev201121391562Yes
154617011701.045.4945.5Integrins. E RuoslahtiJ Clin Invest19911985087No
1547170031700.3539.6954.0The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S LuthraArthritis Rheum19883358796Yes
154816991699.045.0445.0THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. Kozi AsadaAnnu Rev Plant Physiol Plant Mol Biol199915012221Yes
154916991699.036.8436.8Trastuzumab--mechanism of action and use in clinical practice. Clifford A HudisN Engl J Med200717611206No
155016971697.041.2941.3The statistical analysis of enzyme kinetic data. W W ClelandAdv Enzymol Relat Areas Mol Biol19674881884No
155116971697.054.9454.9Validation of a decisional conflict scale. A M O'ConnorMed Decis Making19957898294Yes
155233941697.0135.5867.8Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. A Y Finlay, G K KhanClin Exp Dermatol19948033378Yes
155333941697.093.6846.8Biochemistry of multidrug resistance mediated by the multidrug transporter. M M Gottesman, I PastanAnnu Rev Biochem19938102521No
155416971697.038.3638.4Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. S A BustinJ Mol Endocrinol200212200227No
155516961696.076.9176.9The micronucleus test. W SchmidMutat Res197548190Yes
155616961696.038.8938.9A graphic method for the determination and presentation of binding parameters in a complex system. H E RosenthalAnal Biochem19676048188Yes
155716961696.037.2737.3AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. D Grahame HardieNat Rev Mol Cell Biol200717712357No
1558135611695.1574.6771.8The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jörg Peplies, Frank Oliver GlöcknerNucleic Acids Res201323193283Yes
155916951695.040.7840.8The molecular genetics of cancer. J M BishopScience19873541204No
156016951695.043.0843.1Carbonic anhydrase: chemistry, physiology, and inhibition. T H MarenPhysiol Rev19674964060No
156116951695.069.6869.7Adverse health effects of high-effort/low-reward conditions. J SiegristJ Occup Health Psychol19969547031No
156216951695.033.4633.5The synaptic vesicle cycle. Thomas C SudhofAnnu Rev Neurosci200415217342No
156316951695.069.1969.2Whatever next? Predictive brains, situated agents, and the future of cognitive science. Andy ClarkBehav Brain Sci201323663408No
156484731694.6192.8838.6Stages of embryonic development of the zebrafish. C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F SchillingDev Dyn19958589427Yes
156584711694.2210.1342.0Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan HsuN Engl J Med200415385656Yes
156633881694.0110.655.3Role of free radicals and catalytic metal ions in human disease: an overview. B Halliwell, J M GutteridgeMethods Enzymol19902172697No
156716941694.046.3646.4The glomerular permeability determined by dextran clearance using Sephadex gel filtration. C E MogensenScand J Clin Lab Invest19685637478Yes
156833851692.5109.0854.5Separate visual pathways for perception and action. M A Goodale, A D MilnerTrends Neurosci19921374953No
156916921692.065.3565.3Selenium and human health. Margaret P RaymanLancet201222381456No
157016911691.068.1468.1Negative symptoms in schizophrenia. Definition and reliability. N C AndreasenArch Gen Psychiatry19827165477Yes
1571101431690.5284.1847.4Positional cloning of the mouse obese gene and its human homologue. Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M FriedmanNature19947984236Yes
157216901690.036.1236.1Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. S L FriedmanJ Biol Chem200010644669No
157350691689.7111.7737.3An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J K Eng, A L McCormack, J R YatesJ Am Soc Mass Spectrom199424226387Yes
157467491687.2285.271.3An inventory for measuring clinical anxiety: psychometric properties. A T Beck, N Epstein, G Brown, R A SteerJ Consult Clin Psychol19883204199Yes
157533731686.578.639.3The BCL-2 protein family: opposing activities that mediate cell death. Richard J Youle, Andreas StrasserNat Rev Mol Cell Biol200818097445No
157616861686.031.1231.1Cyclin-dependent kinases: engines, clocks, and microprocessors. D O MorganAnnu Rev Cell Dev Biol19979442875No
157716861686.053.6953.7Receiver operating characteristic curve in diagnostic test assessment. Jayawant N MandrekarJ Thorac Oncol201020736804No
157833721686.0252.29126.1Interactive Tree Of Life (iTOL) v4: recent updates and new developments. Ivica Letunic, Peer BorkNucleic Acids Res201930931475Yes
157933701685.088.0344.0Multiple sclerosis. Alastair Compston, Alasdair ColesLancet200818970977Yes
158033701685.093.8946.9Protective and pathogenic functions of macrophage subsets. Peter J Murray, Thomas A WynnNat Rev Immunol201121997792No
158116841684.039.6839.7Angiogenesis: an organizing principle for drug discovery? Judah FolkmanNat Rev Drug Discov200717396134No
158216831683.059.8959.9Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). G G GlennerN Engl J Med19806154243No
158316831683.010.110.1Chromatographic Separation Of Human Brain Gangliosides. L SvennerholmJ Neurochem196314066623Yes
158450471682.3130.1343.4The rapid generation of mutation data matrices from protein sequences. D T Jones, W R Taylor, J M ThorntonComput Appl Biosci19921633570Yes
158516821682.032.3432.3Generating samples under a Wright-Fisher neutral model of genetic variation. Richard R HudsonBioinformatics200211847089Yes
158616821682.066.7866.8Plastic Embedding Mixtures For Use In Electron Microscopy. H H MollenhauerStain Technol196414127791Yes
158733641682.0101.9951.0The pathogenesis of rheumatoid arthritis. Iain B McInnes, Georg SchettN Engl J Med201122150039No
158816811681.050.7150.7Constructions of masculinity and their influence on men's well-being: a theory of gender and health. W H CourtenaySoc Sci Med200010741575No
158933621681.066.8233.4An automated method for finding molecular complexes in large protein interaction networks. Gary D Bader, Christopher W V HogueBMC Bioinformatics200312525261Yes
159016811681.00.00.0The theory and applications of the exchange of inert gas at the lungs and tissues. S S KetyPharmacol Rev195114833874Yes
159133611680.580.5540.3CAP3: A DNA sequence assembly program. X Huang, A MadanGenome Res199910508846Yes
159284021680.4285.4257.1The hallmarks of aging. Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido KroemerCell201323746838No
159316801680.063.0263.0Paced auditory serial-addition task: a measure of recovery from concussion. D M GronwallPercept Mot Skills1977866038Yes
159416801680.049.4649.5Pedigrees of some mutant strains of Escherichia coli K-12. B J BachmannBacteriol Rev19724568763No
159516801680.032.9432.9Hox genes in vertebrate development. R KrumlaufCell19947913880No
159616801680.055.1755.2The polyvagal perspective. Stephen W PorgesBiol Psychol200717049418No
159733601680.083.8441.9Protein structure prediction on the Web: a case study using the Phyre server. Lawrence A Kelley, Michael J E SternbergNat Protoc200919247286Yes
159816791679.038.6938.7The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. D M KingsleyGenes Dev19948299934No
159916791679.047.1947.2The in vitro micronucleus technique. M FenechMutat Res200011113469No
160033581679.0155.8377.9The amyloid hypothesis of Alzheimer's disease at 25 years. Dennis J Selkoe, John HardyEMBO Mol Med201627025652No
160133551677.567.2733.6A guided tour into subcellular colocalization analysis in light microscopy. S Bolte, F P CordelièresJ Microsc200617210054Yes
160283871677.4320.6564.1UCHIME improves sensitivity and speed of chimera detection. Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob KnightBioinformatics201121700674Yes
160350311677.0108.9836.3Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. J E Darnell, I M Kerr, G R StarkScience19948197455No
160450301676.7119.6539.9Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Prateek Kumar, Steven Henikoff, Pauline C NgNat Protoc200919561590Yes
160516761676.049.1849.2Drugs which inhibit prostaglandin biosynthesis. R J FlowerPharmacol Rev19744208101Yes
160633521676.0341.12170.6WHO Declares COVID-19 a Pandemic. Domenico Cucinotta, Maurizio VanelliActa Biomed202032191675Yes
160733511675.571.6435.8The epigenomics of cancer. Peter A Jones, Stephen B BaylinCell200717320506No
160816751675.018.4118.4Impulses and Physiological States in Theoretical Models of Nerve Membrane. R FitzhughBiophys J196119431309Yes
160916741674.034.1334.1Neurotrophins and their receptors: a convergence point for many signalling pathways. Moses V ChaoNat Rev Neurosci200312671646No
161050201673.3131.3443.8A neural substrate of prediction and reward. W Schultz, P Dayan, P R MontagueScience19979054347No
161116731673.058.0958.1Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. A H ConneyCancer Res19826814745No
161233451672.569.5634.8A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. D Wessel, U I FlüggeAnal Biochem19846731838Yes
161316721672.038.9238.9A revolution in optical manipulation. David G GrierNature200312917694No
161433441672.050.6725.3Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. J Marmur, P DotyJ Mol Biol196214470099Yes
161516711671.039.8939.9Inflammatory bowel disease: etiology and pathogenesis. C FiocchiGastroenterology19989649475No
161616711671.038.3938.4NADPH oxidase: an update. B M BabiorBlood199910029572No
161716711671.038.5338.5PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. Michael F. ThomashowAnnu Rev Plant Physiol Plant Mol Biol199915012220Yes
161816711671.049.6549.6phangorn: phylogenetic analysis in R. Klaus Peter SchliepBioinformatics201121169378Yes
161966821670.5224.5756.1SignalP 4.0: discriminating signal peptides from transmembrane regions. Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik NielsenNat Methods201121959131Yes
162016701670.053.7853.8Synaptic density in human frontal cortex - developmental changes and effects of aging. P R HuttenlocherBrain Res1979427544Yes
162116701670.050.3150.3Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. J A MillerCancer Res19704915745No
162233381669.078.9839.5The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. P Angel, M KarinBiochim Biophys Acta19911751545No
162333381669.078.2539.1Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Robert Visse, Hideaki NagaseCirc Res200312730128No
162416681668.052.5852.6Metallothionein. D H HamerAnnu Rev Biochem19863527054No
162516681668.026.9126.9RNA-dependent DNA polymerase in virions of RNA tumour viruses. D BaltimoreNature19704316300Yes
162633361668.082.8841.4Receptors for purines and pyrimidines. V Ralevic, G BurnstockPharmacol Rev19989755289No
162750031667.7163.9854.7A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. J R Le Gall, S Lemeshow, F SaulnierJAMA19938254858Yes
162816671667.00.00.0Method for the determination of hexosamines in tissues. N F BoasJ Biol Chem195313117829Yes
162916671667.036.5536.5Perceptions of epigenetics. Adrian BirdNature200717522671Yes
163066651666.2191.8748.0The validity of the Hospital Anxiety and Depression Scale. An updated literature review. Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag NeckelmannJ Psychosom Res200211832252No
163116661666.032.3332.3Cell cycle checkpoints: preventing an identity crisis. S J ElledgeScience19968939848No
163233321666.083.8741.9Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. S Schulman, C KearonJ Thromb Haemost200515842354Yes
163333261663.0217.87108.9The structure of coping. L I Pearlin, C SchoolerJ Health Soc Behav1978649936Yes
163466441661.0152.7838.2Use of T7 RNA polymerase to direct expression of cloned genes. F W Studier, A H Rosenberg, J J Dunn, J W DubendorffMethods Enzymol19902199796Yes
163533211660.583.7141.9Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. M Grunstein, D S HognessProc Natl Acad Sci U S A19751105573Yes
163633211660.597.3848.7An information-maximization approach to blind separation and blind deconvolution. A J Bell, T J SejnowskiNeural Comput19957584893Yes
163716591659.054.6854.7Number of people with glaucoma worldwide. H A QuigleyBr J Ophthalmol19968695555No
163816581658.044.2444.2Synergy, antagonism, and what the chequerboard puts between them. F C OddsJ Antimicrob Chemother200312805255No
163933161658.086.6943.3Regulation of chromatin by histone modifications. Andrew J Bannister, Tony KouzaridesCell Res201121321607No
164049731657.7261.4587.1Impact of Event Scale: a measure of subjective stress. M Horowitz, N Wilner, W AlvarezPsychosom Med1979472086Yes
164116571657.048.8148.8Classification of inflammatory bowel disease. J E Lennard-JonesScand J Gastroenterol Suppl19892617184Yes
164299401656.7203.0533.8Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C MelloNature19989486653Yes
1643115951656.4389.3355.6GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J SchünemannBMJ200818436948Yes
164449691656.3196.0665.4The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. C A McHorney, J E Ware, A E RaczekMed Care19938450681Yes
164582811656.264.8513.0Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. S Katz, A B Ford, R W Moskowitz, B A Jackson, M W JaffeJAMA196314044222Yes
164633121656.058.8629.4Method for the isolation of intact islets of Langerhans from the rat pancreas. P E Lacy, M KostianovskyDiabetes19675333500Yes
164716561656.035.9936.0The NCI60 human tumour cell line anticancer drug screen. Robert H ShoemakerNat Rev Cancer200616990858No
164866221655.5190.7147.7Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. B Biswal, F Z Yetkin, V M Haughton, J S HydeMagn Reson Med19958524021Yes
164933111655.594.2347.1Astrocytes: biology and pathology. Michael V Sofroniew, Harry V VintersActa Neuropathol201020012068No
165016551655.046.946.9The many roles for fluorine in medicinal chemistry. William K HagmannJ Med Chem200818570365Yes
165116551655.052.6252.6Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Joseph J VolpeLancet Neurol200919081519No
165233071653.587.4543.7Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis). S M Rogers, L BernatchezMol Ecol200515660930Yes
165316531653.066.1366.1Sample size in qualitative research. M SandelowskiRes Nurs Health19957899572Yes
165416531653.00.00.0Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. E G GrayJ Anat195913829103Yes
165516531653.037.0537.0Introduction to NF-kappaB: players, pathways, perspectives. T D GilmoreOncogene200617072321No
165616521652.041.941.9Neurotrophins and neuronal plasticity. H ThoenenScience19957570017No
165733041652.0121.0560.5The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. T Omura, R SatoJ Biol Chem196414209972Yes
165833031651.566.8833.4A general framework for weighted gene co-expression network analysis. Bin Zhang, Steve HorvathStat Appl Genet Mol Biol200516646834Yes
165966041651.0261.3365.316S ribosomal DNA amplification for phylogenetic study. W G Weisburg, S M Barns, D A Pelletier, D J LaneJ Bacteriol19911987160Yes
166016511651.044.444.4An improved procedure for serum creatine phosphokinase determination. S B RosalkiJ Lab Clin Med19674381359Yes
166116501650.039.1239.1Two pathogenetic types of endometrial carcinoma. J V BokhmanGynecol Oncol19836822361Yes
166216501650.00.00.0Note on the sampling error of the difference between correlated proportions or percentages. Q McNEMARPsychometrika194720254758Yes
166316491649.080.5780.6Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. K O FagerströmAddict Behav1978735910Yes
166416481648.033.3633.4DNA in a material world. Nadrian C SeemanNature200312540916No
166516471647.042.742.7Alpha-crystallin can function as a molecular chaperone. J HorwitzProc Natl Acad Sci U S A19921438232Yes
166616471647.067.5767.6Responses to depression and their effects on the duration of depressive episodes. S Nolen-HoeksemaJ Abnorm Psychol19911757671No
166716471647.031.2131.2Switching and signaling at the telomere. E H BlackburnCell200111572773No
166832911645.5122.8661.4The mini-mental state examination: a comprehensive review. T N Tombaugh, N J McIntyreJ Am Geriatr Soc19921512391No
166916451645.067.2767.3A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. D J SchuirmannJ Pharmacokinet Biopharm19873450848Yes
167016451645.045.4845.5Turnover of inositol phospholipids and signal transduction. Y NishizukaScience19846147898No
167132891644.5106.6253.3Neurocircuitry of addiction. George F Koob, Nora D VolkowNeuropsychopharmacology201019710631No
167216441644.046.4646.5Semiempirical hybrid density functional with perturbative second-order correlation. Stefan GrimmeJ Chem Phys200616438568Yes
167316441644.045.1145.1The origins of the developmental origins theory. D J P BarkerJ Intern Med200717444880No
167416441644.047.0747.1Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. James J P StewartJ Mol Model200717828561Yes
167516431643.019.6219.6Amino acid difference formula to help explain protein evolution. R GranthamScience19744843792Yes
167632861643.066.4833.2Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Gary L Johnson, Razvan LapadatScience200212471242No
167716431643.030.5630.6Neuroblastoma: biological insights into a clinical enigma. Garrett M BrodeurNat Rev Cancer200312612655No
167832841642.066.033.0Upstream and downstream of mTOR. Nissim Hay, Nahum SonenbergGenes Dev200415314020No
167932831641.571.1335.6Protein structure comparison by alignment of distance matrices. L Holm, C SanderJ Mol Biol19938377180Yes
168016411641.049.0149.0Extracellular ATP: effects, sources and fate. J L GordonBiochem J19863006665No
168116411641.039.1439.1The failing heart--an engine out of fuel. Stefan NeubauerN Engl J Med200717360992No
168265591639.8202.5150.6The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. S P Baker, B O'Neill, W Haddon, W B LongJ Trauma19744814394Yes
168316391639.053.7953.8Archaea in coastal marine environments. E F DeLongProc Natl Acad Sci U S A19921608980Yes
168416391639.032.4632.5Simple memory: a theory for archicortex. D MarrPhilos Trans R Soc Lond B Biol Sci19714399412Yes
168516391639.040.3440.3Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Shitij KapurAm J Psychiatry200312505794No
168616381638.037.4537.5In vivo near-infrared fluorescence imaging. John V FrangioniCurr Opin Chem Biol200314580568No
168716381638.053.0753.1The global impact of pre-eclampsia and eclampsia. Lelia DuleySemin Perinatol200919464502No
168816371637.062.6862.7Probiotics in man and animals. R FullerJ Appl Bacteriol19892666378No
168916371637.037.9337.9A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. D MattinglyJ Clin Pathol196214471419Yes
169016361636.034.734.7Neuronal calcium signaling. M J BerridgeNeuron19989697848No
169116361636.050.7350.7Stress and disorders of the stress system. George P ChrousosNat Rev Endocrinol200919488073No
169232691634.574.7237.4Human mesenchymal stem cells modulate allogeneic immune cell responses. Sudeepta Aggarwal, Mark F PittengerBlood200515494428Yes
169316341634.058.4658.5Dual-task interference in simple tasks: data and theory. H PashlerPsychol Bull19947972591No
169416341634.035.4935.5Hematopoietic stem-cell transplantation. Edward A CopelanN Engl J Med200616641398No
169532681634.091.1745.6A perspective on cancer cell metastasis. Christine L Chaffer, Robert A WeinbergScience201121436443No
169632661633.0212.12106.1A clinical method of functional assessment of the shoulder. C R Constant, A H MurleyClin Orthop Relat Res19873791738Yes
169732651632.598.9549.5The benefits of being present: mindfulness and its role in psychological well-being. Kirk Warren Brown, Richard M RyanJ Pers Soc Psychol200312703651Yes
169816321632.071.1271.1Neurogenetic adaptive mechanisms in alcoholism. C R CloningerScience19872882604Yes
169916321632.030.5630.6Germinal centers. I C MacLennanAnnu Rev Immunol19948011279No
170016321632.040.1640.2Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. M J MeaneyAnnu Rev Neurosci200111520931No
170116321632.035.3335.3An approximately unbiased test of phylogenetic tree selection. Hidetoshi ShimodairaSyst Biol200212079646Yes
170216321632.041.7541.8Understanding biofilm resistance to antibacterial agents. David DaviesNat Rev Drug Discov200312563302No
170316311631.056.4256.4Frontal-subcortical circuits and human behavior. J L CummingsArch Neurol19938352676No
170416311631.029.1629.2Maximum-likelihood density modification. T C TerwilligerActa Crystallogr D Biol Crystallogr200010944333Yes
170532601630.077.1938.6Adipose tissue as an endocrine organ. Erin E Kershaw, Jeffrey S FlierJ Clin Endocrinol Metab200415181022No
170616291629.058.2658.3Cell damage in the brain: a speculative synthesis. B K SiesjöJ Cereb Blood Flow Metab19816276420No
170716291629.034.8134.8Bone morphogenetic proteins: multifunctional regulators of vertebrate development. B L HoganGenes Dev19968682290No
170816291629.030.3530.4Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. M G GustafssonJ Microsc200010810003Yes
170932571628.5129.9165.0The Emerging Hallmarks of Cancer Metabolism. Natalya N Pavlova, Craig B ThompsonCell Metab201626771115No
171097681628.0226.7837.8Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuireScience19873798106Yes
171116281628.072.4872.5Mood and memory. G H BowerAm Psychol19817224324Yes
171248831627.7208.1869.4The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Susan Michie, Maartje M van Stralen, Robert WestImplement Sci201121513547No
171332521626.085.2742.6Early identification of refractory epilepsy. P Kwan, M J BrodieN Engl J Med200010660394Yes
171416261626.023.1323.1Structural considerations in the interaction of DNA and acridines. L S LermanJ Mol Biol196113761054Yes
171516261626.038.4538.5Five rules for the evolution of cooperation. Martin A NowakScience200617158317No
171665021625.5280.3970.1A rating scale for mania: reliability, validity and sensitivity. R C Young, J T Biggs, V E Ziegler, D A MeyerBr J Psychiatry1978728692Yes
171716251625.042.5742.6Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. D A DoughertyScience19968539615No
1718113701624.3339.6748.5AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J OlsonJ Comput Chem200919399780Yes
171916241624.046.0746.1Fluorescence energy transfer as a spectroscopic ruler. L StryerAnnu Rev Biochem1978354506No
172016241624.049.0449.0Stress signalling pathways that impair prefrontal cortex structure and function. Amy F T ArnstenNat Rev Neurosci200919455173No
172132471623.587.8843.9Bronchopulmonary dysplasia. A H Jobe, E BancalariAm J Respir Crit Care Med200111401896No
172232471623.5110.055.0Neutrophil recruitment and function in health and inflammation. Elzbieta Kolaczkowska, Paul KubesNat Rev Immunol201323435331No
172316231623.033.0733.1Structural features in eukaryotic mRNAs that modulate the initiation of translation. M KozakJ Biol Chem19911939050No
172416231623.046.346.3The basal ganglia: focused selection and inhibition of competing motor programs. J W MinkProg Neurobiol19969004351No
172516231623.034.2834.3The caveolae membrane system. R G AndersonAnnu Rev Biochem19989759488No
172616221622.045.2145.2Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. B HilleJ Gen Physiol1977300786Yes
172716221622.050.8750.9Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. D W ChoiTrends Neurosci19882469166No
172832431621.596.7548.4Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. M Karas, F HillenkampAnal Chem19883239801Yes
1729129701621.2377.1147.1The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. Ziad S Nasreddine, Natalie A Phillips, Valérie Bédirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard ChertkowJ Am Geriatr Soc200515817019Yes
173016211621.058.0258.0The linear-quadratic formula and progress in fractionated radiotherapy. J F FowlerBr J Radiol19892670032No
173148631621.0147.1449.0Simultaneous inference in general parametric models. Torsten Hothorn, Frank Bretz, Peter WestfallBiom J200818481363No
173216191619.047.347.3Metalloproteinases and their inhibitors in matrix remodeling. L M MatrisianTrends Genet19902132731No
173316191619.027.727.7Cell cycle checkpoint signaling through the ATM and ATR kinases. R T AbrahamGenes Dev200111544175No
173432361618.076.6238.3Rapid and sensitive protein similarity searches. D J Lipman, W R PearsonScience19852983426Yes
173516181618.041.1741.2The importance of the ratio of omega-6/omega-3 essential fatty acids. A P SimopoulosBiomed Pharmacother200212442909No
173648531617.794.8431.6T-Coffee: A novel method for fast and accurate multiple sequence alignment. C Notredame, D G Higgins, J HeringaJ Mol Biol200010964570Yes
173716171617.036.9436.9VLA proteins in the integrin family: structures, functions, and their role on leukocytes. M E HemlerAnnu Rev Immunol19902188667No
173897001616.7335.155.9Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R TannenbaumAnal Biochem19827181105Yes
173916161616.057.7957.8Aging, natural death, and the compression of morbidity. J F FriesN Engl J Med19807383070Yes
174016161616.00.00.0Discharge patterns and functional organization of mammalian retina. S W KufflerJ Neurophysiol195313035466Yes
174132291614.595.2947.6Unified approach for molecular dynamics and density-functional theory. R Car, M ParrinelloPhys Rev Lett198510032153Yes
174216141614.058.5258.5Interhemispheric differences in the localization of psychological processes in man. B MilnerBr Med Bull19714937273No
174316141614.071.3571.3The structure and properties of the sense of coherence scale. A AntonovskySoc Sci Med19938480217Yes
174432281614.089.1144.6Diarrheagenic Escherichia coli. J P Nataro, J B KaperClin Microbiol Rev19989457432No
174516131613.036.9336.9Cellular oncogenes and retroviruses. J M BishopAnnu Rev Biochem19836351725No
174632251612.585.943.0Molecular mechanisms of long noncoding RNAs. Kevin C Wang, Howard Y ChangMol Cell201121925379No
174764491612.2212.953.2Common method biases in behavioral research: a critical review of the literature and recommended remedies. Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P PodsakoffJ Appl Psychol200314516251No
174848341611.3176.5958.9Multiple imputation using chained equations: Issues and guidance for practice. Ian R White, Patrick Royston, Angela M WoodStat Med201121225900Yes
174916111611.030.4930.5Protein kinases--the major drug targets of the twenty-first century? Philip CohenNat Rev Drug Discov200212120282No
175032221611.081.9441.0ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. Markus Wiederstein, Manfred J SipplNucleic Acids Res200717517781Yes
175116111611.045.4345.4Understanding organofluorine chemistry. An introduction to the C-F bond. David O'HaganChem Soc Rev200818197347No
175216101610.051.0451.0Cellular defenses against damage from reactive oxygen species. B P YuPhysiol Rev19948295932No
175316101610.049.7549.8Apoptosis in cancer: from pathogenesis to treatment. Rebecca S Y WongJ Exp Clin Cancer Res201121943236No
175432171608.562.5831.3Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. M E Greenberg, E B ZiffNature19846090941Yes
175516081608.039.2239.2Recognition of errors in three-dimensional structures of proteins. M J SipplProteins19938108378Yes
175616071607.039.5139.5Tumor necrosis factor (TNF). L J OldScience19852413547Yes
175716061606.045.5545.5Ionic dependence of glutamate neurotoxicity. D W ChoiJ Neurosci19872880938Yes
175816061606.040.6540.6External validity of randomised controlled trials: "to whom do the results of this trial apply?". Peter M RothwellLancet200515639683Yes
175916041604.081.2281.2Hydrogel: Preparation, characterization, and applications: A review. Enas M AhmedJ Adv Res201525750745No
176016041604.0221.62221.6COVID-19 and mental health: A review of the existing literature. Ravi Philip RajkumarAsian J Psychiatr202032302935Yes
176116031603.056.7456.7The case-crossover design: a method for studying transient effects on the risk of acute events. M MaclureAm J Epidemiol19911985444Yes
176216031603.00.00.0Application of a Theory of Enzyme Specificity to Protein Synthesis. D E KoshlandProc Natl Acad Sci U S A195816590179Yes
176332061603.0152.176.0Making sense of Cronbach's alpha. Mohsen Tavakol, Reg DennickInt J Med Educ201128029643No
176432051602.5114.0157.0Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. M M Bradley, P J LangJ Behav Ther Exp Psychiatry19947962581Yes
176532041602.067.1433.6The Ki-67 protein: from the known and the unknown. T Scholzen, J GerdesJ Cell Physiol200010653597No
176632021601.0112.8756.4Avoiding false positives with PCR. S Kwok, R HiguchiNature19892716852Yes
176716011601.046.0446.0The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. R R LlinásScience19883059497No
176816011601.033.4133.4The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. A G PearseJ Histochem Cytochem19694143745No
176916011601.00.00.0Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. O OuchterlonyActa Pathol Microbiol Scand195313079779Yes
177016011601.00.00.0Cerebral blood flow and oxygen consumption in man. N A LassenPhysiol Rev195913645234Yes
177116011601.030.9631.0The microRNA Registry. Sam Griffiths-JonesNucleic Acids Res200414681370Yes
177232011600.567.6433.8Inhibitors of mammalian G1 cyclin-dependent kinases. C J Sherr, J M RobertsGenes Dev19957758941No
177316001600.040.6240.6Molecular biology of prion diseases. S B PrusinerScience19911675487No
177416001600.031.6431.6An analysis of vertebrate mRNA sequences: intimations of translational control. M KozakJ Cell Biol19911955461No
177532001600.066.1233.1Signaling to NF-kappaB. Matthew S Hayden, Sankar GhoshGenes Dev200415371334No
177647991599.7133.1144.4Cell death: the significance of apoptosis. A H Wyllie, J F Kerr, A R CurrieInt Rev Cytol19807014501No
177731991599.563.9732.0The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. J O'Keefe, J DostrovskyBrain Res19715124915Yes
177831991599.561.7930.9Automated MAD and MIR structure solution. T C Terwilliger, J BerendzenActa Crystallogr D Biol Crystallogr199910089316Yes
177915991599.044.4544.5Multiple imputation of discrete and continuous data by fully conditional specification. Stef van BuurenStat Methods Med Res200717621469Yes
178015991599.057.0957.1Cytokines in inflammatory bowel disease. Markus F NeurathNat Rev Immunol201424751956No
178115981598.034.2334.2On finding all suboptimal foldings of an RNA molecule. M ZukerScience19892468181No
178231961598.088.5744.3Polyamines. C W Tabor, H TaborAnnu Rev Biochem19846206782No
178315981598.041.8241.8Task switching. Stephen MonsellTrends Cogn Sci200312639695Yes
178447941598.0114.2838.1Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck ØrntoftCancer Res200415289330Yes
178515971597.052.0552.0Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). M N MarshGastroenterology19921727768No
178615971597.044.8244.8Gold-catalyzed organic reactions. A Stephen K HashmiChem Rev200717580975Yes
178715971597.053.0553.0Asthma phenotypes: the evolution from clinical to molecular approaches. Sally E WenzelNat Med201222561835No
178831941597.0156.3478.2Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. Ivica Letunic, Peer BorkNucleic Acids Res201627095192Yes
178915961596.036.236.2Thiazolidinediones. Hannele Yki-JärvinenN Engl J Med200415356308No
179031911595.583.3641.7Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. D B Dill, D L CostillJ Appl Physiol19744850854Yes
179115951595.072.6372.6Measurement of health state utilities for economic appraisal. G W TorranceJ Health Econ198610311607No
179215951595.036.4236.4Getting formal with dopamine and reward. Wolfram SchultzNeuron200212383780No
179315941594.028.7628.8Altering the genome by homologous recombination. M R CapecchiScience19892660260No
179415941594.070.8770.9The contribution of low birth weight to infant mortality and childhood morbidity. M C McCormickN Engl J Med19853880598No
179515941594.036.6636.7A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. D A GewirtzBiochem Pharmacol199910075079No
179615941594.036.3536.4Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. S C ManolagasEndocr Rev200010782361No
179715931593.036.6836.7Neurovascular regulation in the normal brain and in Alzheimer's disease. Costantino IadecolaNat Rev Neurosci200415100718No
179815921592.038.9639.0The corticosteroid receptor hypothesis of depression. F HolsboerNeuropsychopharmacology200011027914No
179931831591.577.5638.8A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. S Tabor, C C RichardsonProc Natl Acad Sci U S A19853156376Yes
180031821591.091.3845.7Oxidative stress, glutamate, and neurodegenerative disorders. J T Coyle, P PuttfarckenScience19937901908No
180115901590.031.3631.4Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. D I SvergunBiophys J199910354416Yes
180215901590.035.6535.6Hypertrophic cardiomyopathy: a systematic review. Barry J MaronJAMA200211886323No
180315891589.048.4548.5Chlorophyll fluorescence: a probe of photosynthesis in vivo. Neil R BakerAnnu Rev Plant Biol200818444897No
180415881588.048.7548.8Efficient analysis of experimental observations. W J DixonAnnu Rev Pharmacol Toxicol19807387124Yes
180515881588.043.9143.9Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. P A BradfordClin Microbiol Rev200111585791No
180615871587.056.6156.6Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. P HolzerPharmacol Rev19911852779No
180715871587.041.8741.9Precision mapping of quantitative trait loci. Z B ZengGenetics19948013918Yes
180815871587.035.5735.6The proto-oncogene Bcl-2 and its role in regulating apoptosis. G KroemerNat Med19979176486No
180915861586.051.7951.8Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. W H OldendorfAm J Physiol19715124307Yes
181015861586.054.9354.9The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. E J KhantzianHarv Rev Psychiatry19979385000No
181131711585.597.1548.6Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. D S Bredt, S H SnyderProc Natl Acad Sci U S A19901689048Yes
181215851585.065.3265.3Regulation of noradrenaline release by presynaptic receptor systems. K StarkeRev Physiol Biochem Pharmacol197714389No
181315851585.034.3334.3Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. G L SemenzaAnnu Rev Cell Dev Biol199910611972No
181415831583.029.4529.4How cells read TGF-beta signals. J MassaguéNat Rev Mol Cell Biol200011252892No
181531631581.565.8732.9Fitting a mixture model by expectation maximization to discover motifs in biopolymers. T L Bailey, C ElkanProc Int Conf Intell Syst Mol Biol19947584402Yes
181647441581.3115.6938.6Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. Earl S Ford, Wayne H Giles, William H DietzJAMA200211790215Yes
181715811581.044.0244.0Dithiothreitol, A New Protective Reagent For Sh Groups. W W ClelandBiochemistry196414192894Yes
181815801580.052.5852.6Which elements are excited in electrical stimulation of mammalian central nervous system: a review. J B RanckBrain Res19751102064No
181915801580.048.6348.6The role of the amygdala in fear and anxiety. M DavisAnnu Rev Neurosci19921575447No
182015801580.035.6335.6The genetical evolution of social behaviour. II. W D HamiltonJ Theor Biol19645875340Yes
182115801580.047.4947.5Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. L BravoNutr Rev19989838798No
182215801580.031.2331.2Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. R K JainNat Med200111533692No
182331591579.562.4831.2NF-kappaB regulation in the immune system. Qiutang Li, Inder M VermaNat Rev Immunol200212360211No
182431571578.570.435.2Lipopolysaccharide endotoxins. Christian R H Raetz, Chris WhitfieldAnnu Rev Biochem200212045108No
182515781578.037.3637.4The blood-brain barrier: bottleneck in brain drug development. William M PardridgeNeuroRx200515717053No
182615771577.034.0634.1Mechanisms of bone metastasis. G David RoodmanN Engl J Med200415084698No
182731541577.092.6446.3Density functionals with broad applicability in chemistry. Yan Zhao, Donald G TruhlarAcc Chem Res200818186612Yes
182831521576.0115.7957.9A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. J A Horne, O OstbergInt J Chronobiol19761027738Yes
182915761576.042.6442.6The complete general secretory pathway in gram-negative bacteria. A P PugsleyMicrobiol Rev19938096622No
183031521576.0174.3587.2Natural Products as Sources of New Drugs from 1981 to 2014. David J Newman, Gordon M CraggJ Nat Prod201626852623No
183147251575.0128.8843.0Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. M Hasegawa, H Kishino, T YanoJ Mol Evol19853934395Yes
183215741574.052.552.5Biology of interleukin 1. C A DinarelloFASEB J19883277884No
183315741574.045.045.0Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. S HakomoriAnnu Rev Biochem19817023369No
183431481574.068.4734.2Neurotrophins: roles in neuronal development and function. E J Huang, L F ReichardtAnnu Rev Neurosci200111520916No
183531481574.099.8249.9Palladium-catalyzed ligand-directed C-H functionalization reactions. Thomas W Lyons, Melanie S SanfordChem Rev201020078038No
183615731573.040.0840.1Aspergillus fumigatus and aspergillosis. J P LatgéClin Microbiol Rev199910194462No
183715731573.029.9830.0Immunosuppressive networks in the tumour environment and their therapeutic relevance. Weiping ZouNat Rev Cancer200515776005No
183815731573.036.6336.6Insulin and insulin-like growth factor signalling in neoplasia. Michael PollakNat Rev Cancer200819029956No
183931451572.564.7532.4Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. E Krissinel, K HenrickActa Crystallogr D Biol Crystallogr200415572779Yes
184047171572.3115.1538.4Two-photon laser scanning fluorescence microscopy. W Denk, J H Strickler, W W WebbScience19902321027Yes
1841172931572.1547.2949.8A new equation to estimate glomerular filtration rate. Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef CoreshAnn Intern Med200919414839Yes
184231441572.098.6449.3Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. G R Gibson, M B RoberfroidJ Nutr19957782892No
184331441572.057.9929.0The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Michael H Glickman, Aaron CiechanoverPhysiol Rev200211917093No
184431441572.088.1344.1Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Sally S Dickerson, Margaret E KemenyPsychol Bull200415122924Yes
184515711571.037.7937.8HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. J M CoffinScience19957824947Yes
184615711571.030.430.4Regulatory T cells, tumour immunity and immunotherapy. Weiping ZouNat Rev Immunol200616557261No
184715701570.041.5341.5Molecular bases of the acute coronary syndromes. P LibbyCirculation19957758192No
184831391569.561.2530.6The evolutionary fate and consequences of duplicate genes. M Lynch, J S ConeryScience200011073452No
184915691569.059.9760.0Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. P HolzerNeuroscience19883288903No
185015691569.029.6229.6Intrinsically unstructured proteins. Peter TompaTrends Biochem Sci200212368089No
185131341567.060.5230.3Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. O Tetsu, F McCormickNature199910201372Yes
185231341567.0126.8163.4Methods for the thematic synthesis of qualitative research in systematic reviews. James Thomas, Angela HardenBMC Med Res Methodol200818616818Yes
185315671567.0103.95104.0The Global Epidemic of the Metabolic Syndrome. Mohammad G SaklayenCurr Hypertens Rep201829480368No
185431311565.596.7948.4Oxidative stress and diabetic complications. Ferdinando Giacco, Michael BrownleeCirc Res201021030723No
185515651565.00.00.0The estimation of phosphorus. R J AllenBiochem J194016747230Yes
185631291564.567.9734.0Microtubules as a target for anticancer drugs. Mary Ann Jordan, Leslie WilsonNat Rev Cancer200415057285No
185715641564.0106.48106.5Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. C S NeerJ Bone Joint Surg Am19725054450Yes
185815641564.00.00.0A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. B C HummelCan J Biochem Physiol195914405350Yes
185915641564.039.0239.0Marine viruses--major players in the global ecosystem. Curtis A SuttleNat Rev Microbiol200717853907No
186015631563.028.5228.5Selforganization of matter and the evolution of biological macromolecules. M EigenNaturwissenschaften19714942363No
186115631563.066.5566.5Structure, Function, and Evolution of Coronavirus Spike Proteins. Fang LiAnnu Rev Virol201627578435No
186231251562.567.0933.5Complex networks orchestrate epithelial-mesenchymal transitions. Jean Paul Thiery, Jonathan P SleemanNat Rev Mol Cell Biol200616493418No
186315621562.033.3733.4From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. W A CatterallNeuron200010798388No
186415621562.029.7429.7Protein degradation and protection against misfolded or damaged proteins. Alfred L GoldbergNature200314685250No
186531231561.5134.1567.1Parkinson's disease. Lorraine V Kalia, Anthony E LangLancet201525904081No
186615611561.047.6147.6Ordinary magic. Resilience processes in development. A S MastenAm Psychol200111315249Yes
186715611561.046.3146.3A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Ozcan ErelClin Biochem200415003729Yes
186815611561.035.7135.7Neurotrophin-regulated signalling pathways. Louis F ReichardtPhilos Trans R Soc Lond B Biol Sci200616939974No
186915601560.037.2337.2The biology of incretin hormones. Daniel J DruckerCell Metab200616517403No
187015591559.052.4552.5Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. Virginia A MoyerAnn Intern Med201222801674No
187146761558.7120.940.3Optimization by simulated annealing. S Kirkpatrick, C D Gelatt, M P VecchiScience198317813860Yes
187231161558.065.3932.7Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. C B Lozzio, B B LozzioBlood1975163658Yes
187331151557.5100.9850.5The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. R Doll, R PetoJ Natl Cancer Inst19817017215No
187446721557.387.1629.1Notch signaling: cell fate control and signal integration in development. S Artavanis-Tsakonas, M D Rand, R J LakeScience199910221902No
187531131556.574.2837.1Unravelling the pathogenesis of inflammatory bowel disease. R J Xavier, D K PodolskyNature200717653185No
187615561556.031.3931.4The ubiquitin-proteasome proteolytic pathway. A CiechanoverCell19947923371No
187715561556.025.8725.9Neuronal specification in the spinal cord: inductive signals and transcriptional codes. T M JessellNat Rev Genet200011262869No
187831121556.069.9535.0The human plasma proteome: history, character, and diagnostic prospects. N Leigh Anderson, Norman G AndersonMol Cell Proteomics200212488461No
187931101555.066.8333.4Cancer metastasis: building a framework. Gaorav P Gupta, Joan MassaguéCell200617110329No
188015551555.052.0952.1The role of senescent cells in ageing. Jan M van DeursenNature201424848057No
188146641554.792.2630.8Efficient selection for high-expression transfectants with a novel eukaryotic vector. H Niwa, K Yamamura, J MiyazakiGene19911660837Yes
188246641554.7103.834.6Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. M A Frohman, M K Dush, G R MartinProc Natl Acad Sci U S A19882461560Yes
188315541554.077.4777.5Bias in analytic research. D L SackettJ Chronic Dis1979447779Yes
188431081554.0123.461.7Alginate: properties and biomedical applications. Kuen Yong Lee, David J MooneyProg Polym Sci201222125349Yes
188515541554.058.7458.7Modeling Development and Disease with Organoids. Hans CleversCell201627315476No
188631061553.043.4321.7Computed circular dichroism spectra for the evaluation of protein conformation. N Greenfield, G D FasmanBiochemistry19695346390Yes
188762081552.0153.4538.4Most mammalian mRNAs are conserved targets of microRNAs. Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P BartelGenome Res200918955434Yes
188831041552.079.539.8Dali server: conservation mapping in 3D. Liisa Holm, Päivi RosenströmNucleic Acids Res201020457744Yes
188931031551.558.3529.2Mutations affecting segment number and polarity in Drosophila. C Nüsslein-Volhard, E WieschausNature19806776413Yes
189015511551.077.6177.6Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. F E ZajacCrit Rev Biomed Eng19892676342No
189115511551.032.4832.5Drug discovery: a historical perspective. J DrewsScience200010720314No
189215511551.033.3233.3Tumor metastasis: mechanistic insights and clinical challenges. Patricia S SteegNat Med200616892035No
189331011550.5100.3250.2Neoantigens in cancer immunotherapy. Ton N Schumacher, Robert D SchreiberScience201525838375No
189415501550.041.0741.1A more meaningful scoring system for determining the severity of coronary heart disease. G G GensiniAm J Cardiol19836823874Yes
189546481549.388.4629.5A highly sensitive adenylate cyclase assay. Y Salomon, C Londos, M RodbellAnal Biochem19744827395Yes
189615491549.036.5636.6The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. H MaedaAdv Enzyme Regul200111384745No
189730981549.066.433.2Self-assembly at all scales. George M Whitesides, Bartosz GrzybowskiScience200211923529Yes
189815471547.042.3942.4Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. A FabiatoAm J Physiol19836346892No
189930941547.073.7536.9Malignant gliomas in adults. Patrick Y Wen, Santosh KesariN Engl J Med200818669428No
190030931546.5102.7951.4The future of immune checkpoint therapy. Padmanee Sharma, James P AllisonScience201525838373No
1901154621546.2368.7736.9Multilineage potential of adult human mesenchymal stem cells. M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R MarshakScience199910102814Yes
190215461546.073.473.4Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. Kevin A HallgrenTutor Quant Methods Psychol201222833776Yes
190346361545.3155.3551.8Phylogenetic identification and in situ detection of individual microbial cells without cultivation. R I Amann, W Ludwig, K H SchleiferMicrobiol Rev19957535888No
190430901545.062.0131.0Toll-like receptor control of the adaptive immune responses. Akiko Iwasaki, Ruslan MedzhitovNat Immunol200415454922No
190515441544.047.2247.2Domino Reactions in Organic Synthesis. Lutz F. TietzeChem Rev199611848746Yes
190692601543.3219.3536.6GROMACS: fast, flexible, and free. David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C BerendsenJ Comput Chem200516211538Yes
190715421542.030.3630.4E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. J R NevinsScience19921411535Yes
190815421542.044.0444.0Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. A E PeggCancer Res19883123052No
190915421542.00.00.0Cerebral vascular accidents in patients over the age of 60. II. Prognosis. J RankinScott Med J195713432835Yes
191030831541.574.6937.3Steatohepatitis: a tale of two "hits"? C P Day, O F JamesGastroenterology19989547102No
191130831541.574.9437.5Cell signaling by receptor tyrosine kinases. Mark A Lemmon, Joseph SchlessingerCell201020602996No
191230821541.071.835.9New Giemsa method for the differential staining of sister chromatids. P Perry, S WolffNature19744138930Yes
191315411541.053.7453.7Multimodal approach to control postoperative pathophysiology and rehabilitation. H KehletBr J Anaesth19979175983No
191415401540.056.1356.1Statistical analysis of enzyme kinetic data. W W ClelandMethods Enzymol1979502857Yes
191515401540.034.9234.9Pathogenesis of group A streptococcal infections. M W CunninghamClin Microbiol Rev200010885988No
191615401540.043.5643.6Glycobiology: Toward Understanding the Function of Sugars. Raymond A. DwekChem Rev199611848770Yes
191715401540.065.5565.5Macrophage Polarization. Peter J MurrayAnnu Rev Physiol201727813830No
191815391539.030.9530.9RNA silencing in plants. David BaulcombeNature200415372043No
191915381538.052.9252.9Biological applications of ionophores. B C PressmanAnnu Rev Biochem1976786156No
192015381538.034.034.0Molecular themes in oncogenesis. J M BishopCell19911988146No
192115381538.047.847.8Evidence for a central component of post-injury pain hypersensitivity. C J WoolfNature19836656869Yes
192215371537.042.6442.6Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Y Ben-AriNeuroscience19852859548No
192330741537.078.9839.5Empirical threshold values for quantitative trait mapping. G A Churchill, R W DoergeGenetics19947851788Yes
192430731536.50.00.0A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. G Schmidt, S J ThannhauserJ Biol Chem194521005717Yes
192515361536.030.7730.8The Buccaneer software for automated model building. 1. Tracing protein chains. Kevin CowtanActa Crystallogr D Biol Crystallogr200616929101Yes
192615351535.045.8245.8Calcium release from the sarcoplasmic reticulum. M EndoPhysiol Rev197713441Yes
192715351535.060.960.9A structured interview guide for the Hamilton Depression Rating Scale. J B WilliamsArch Gen Psychiatry19883395203Yes
192815351535.00.00.0Nutrition needs of mammalian cells in tissue culture. H EagleScience195513255879Yes
192930701535.015.517.8Junctional complexes in various epithelia. M G Farquhar, G E PaladeJ Cell Biol196313944428Yes
193015351535.031.2931.3Antigen-Antibody Crossed Electrophoresis. C B LaurellAnal Biochem196514302464Yes
193130691534.5105.4552.7Diabetes and cardiovascular disease. The Framingham study. W B Kannel, D L McGeeJAMA1979430798Yes
193215341534.024.0424.0An enzymic method for the trace iodination of immunoglobulins and other proteins. J J MarchalonisBiochem J19694185494Yes
193315341534.048.1448.1The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. G R BuettnerArch Biochem Biophys19938434935No
193415341534.035.9536.0Upconversion and anti-Stokes processes with f and d ions in solids. François AuzelChem Rev200414719973Yes
193515341534.041.9642.0n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Philip C CalderAm J Clin Nutr200616841861No
193615341534.038.0238.0Use and misuse of the receiver operating characteristic curve in risk prediction. Nancy R CookCirculation200717309939Yes
193730671533.5114.257.1Universal chemical assay for the detection and determination of siderophores. B Schwyn, J B NeilandsAnal Biochem19872952030Yes
193830661533.067.633.8Cell migration: a physically integrated molecular process. D A Lauffenburger, A F HorwitzCell19968608589No
193915331533.061.4661.5α-band oscillations, attention, and controlled access to stored information. Wolfgang KlimeschTrends Cogn Sci201223141428No
194015331533.058.5158.5A Protection Motivation Theory of Fear Appeals and Attitude Change1. Ronald W RogersJ Psychol197528136248Yes
194130641532.070.8535.4A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. L Buck, R AxelCell19911840504Yes
194215321532.038.7238.7Early signals in the mitogenic response. E RozengurtScience19863018928No
194315321532.036.8836.9Myeloperoxidase: friend and foe. Seymour J KlebanoffJ Leukoc Biol200515689384No
194415321532.043.4343.4Surface plasmon resonance sensors for detection of chemical and biological species. Jirí HomolaChem Rev200818229953No
194515311531.045.3745.4Recent advances in the biochemistry of polyamines in eukaryotes. A E PeggBiochem J19863087344No
194630621531.061.7830.9The Bcl2 family: regulators of the cellular life-or-death switch. Suzanne Cory, Jerry M AdamsNat Rev Cancer200212209154No
194776551531.0152.2930.5Prospective identification of tumorigenic breast cancer cells. Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F ClarkeProc Natl Acad Sci U S A200312629218Yes
194861211530.2119.9430.0A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. B M Bolstad, R A Irizarry, M Astrand, T P SpeedBioinformatics200312538238Yes
194915301530.048.7348.7Some observations upon a new inhibitor of monoamine oxidase in brain tissue. J P JohnstonBiochem Pharmacol19685659776Yes
195030601530.056.4628.2Cellular motility driven by assembly and disassembly of actin filaments. Thomas D Pollard, Gary G BorisyCell200312600310No
195130581529.062.5831.3Development by self-digestion: molecular mechanisms and biological functions of autophagy. Beth Levine, Daniel J KlionskyDev Cell200415068787No
195261121528.0208.2852.1Guidelines for the process of cross-cultural adaptation of self-report measures. D E Beaton, C Bombardier, F Guillemin, M B FerrazSpine (Phila Pa 1976)200011124735No
195315271527.050.6950.7Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. K Anders EricssonAcad Med200415383395No
195430531526.563.131.6Coordination of circadian timing in mammals. Steven M Reppert, David R WeaverNature200212198538No
195545781526.096.8932.3Adjusting batch effects in microarray expression data using empirical Bayes methods. W Evan Johnson, Cheng Li, Ariel RabinovicBiostatistics200716632515Yes
195630501525.0180.6490.3A scaled version of the General Health Questionnaire. D P Goldberg, V F HillierPsychol Med1979424481Yes
195715251525.036.9136.9Clinical features of metastatic bone disease and risk of skeletal morbidity. Robert E ColemanClin Cancer Res200617062708No
195815251525.041.341.3Stress and depression. Constance HammenAnnu Rev Clin Psychol200517716090No
195930501525.095.0447.5How good are my data and what is the resolution? Philip R Evans, Garib N MurshudovActa Crystallogr D Biol Crystallogr201323793146Yes
196015241524.041.3141.3Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. L A LiottaCancer Res19862998604No
196115241524.034.4534.5Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). K M FoxLancet200313678872Yes
196215241524.063.2763.3Nonalcoholic fatty liver disease: a systematic review. Mary E RinellaJAMA201526057287No
196315231523.038.0838.1Trophic factors and neuronal survival. Y A BardeNeuron19892697237No
196415231523.029.7729.8Macromolecular crowding: obvious but underappreciated. R J EllisTrends Biochem Sci200111590012No
196515231523.033.833.8Ordered porous materials for emerging applications. Mark E DavisNature200212075343No
196615231523.028.3828.4Vienna RNA secondary structure server. Ivo L HofackerNucleic Acids Res200312824340Yes
196730451522.5102.0551.0Thermodynamics of protein association reactions: forces contributing to stability. P D Ross, S SubramanianBiochemistry19817248271Yes
196830441522.091.4145.7Quality control and preprocessing of metagenomic datasets. Robert Schmieder, Robert EdwardsBioinformatics201121278185Yes
196945631521.096.8232.3The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. S K Hanks, A M Quinn, T HunterScience19883291115No
197015201520.037.9137.9Type I diabetes mellitus. A chronic autoimmune disease. G S EisenbarthN Engl J Med19863517648No
197115201520.018.5918.6A soluble protein characteristic of the nervous system. B W MooreBiochem Biophys Res Commun19654953930Yes
197230401520.075.8237.9Obesity. David W Haslam, W Philip T JamesLancet200516198769No
197330381519.070.9235.5Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. F Q Schafer, G R BuettnerFree Radic Biol Med200111368918No
197415191519.034.3134.3The Unified Medical Language System (UMLS): integrating biomedical terminology. Olivier BodenreiderNucleic Acids Res200414681409Yes
197515181518.048.0248.0Stability of proteins: small globular proteins. P L PrivalovAdv Protein Chem197944431No
197615171517.041.9141.9Bioactive microbial metabolites. János BérdyJ Antibiot (Tokyo)200515813176No
197715161516.034.4234.4Dopamine (3-hydroxytyramine) and brain function. O HornykiewiczPharmacol Rev19665328389No
197830321516.067.0733.5NF-kappaB: a key role in inflammatory diseases. P P Tak, G S FiresteinJ Clin Invest200111134171No
197945481516.0102.334.1Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Hartmuth C. Kolb, M G Finn, K. Barry SharplessAngew Chem Int Ed Engl200111433435Yes
198015131513.047.9848.0Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. C A BarnesJ Comp Physiol Psychol1979221551Yes
198115131513.047.1747.2The law of attrition. Gunther EysenbachJ Med Internet Res200515829473Yes
198245371512.398.432.8Osteoclast differentiation and activation. William J Boyle, W Scott Simonet, David L LaceyNature200312748652No
198315121512.040.040.0Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. H S PenefskyJ Biol Chem197716006Yes
198415121512.089.4289.4Stimulated acoustic emissions from within the human auditory system. D T KempJ Acoust Soc Am1978744838Yes
198515121512.050.6150.6A Social Neuroscience Perspective on Adolescent Risk-Taking. Laurence SteinbergDev Rev200818509515Yes
198630241512.0140.8770.4MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Rajesha Rupaimoole, Frank J SlackNat Rev Drug Discov201728209991No
198790671511.2260.1443.4A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle CharpentierScience201222745249Yes
198815111511.055.7355.7Atherogenesis: a postprandial phenomenon. D B ZilversmitCirculation1979222498Yes
198915111511.028.0428.0Aggresomes, inclusion bodies and protein aggregation. R R KopitoTrends Cell Biol200011121744No
199030221511.080.1140.1The gut microbiota shapes intestinal immune responses during health and disease. June L Round, Sarkis K MazmanianNat Rev Immunol200919343057No
199130221511.0104.7952.4Van der Waals heterostructures. A K Geim, I V GrigorievaNature201323887427Yes
199245281509.3162.1954.1Hydroperoxide metabolism in mammalian organs. B Chance, H Sies, A BoverisPhysiol Rev197937532Yes
199315091509.050.150.1Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. H J GundersenJ Microsc19863761363Yes
199415081508.033.0733.1Far-field optical nanoscopy. Stefan W HellScience200717525330No
199515081508.032.7832.8The tumor microenvironment and its role in promoting tumor growth. T L WhitesideOncogene200818836471No
199645221507.3115.3838.5Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. B Fischl, M I Sereno, A M DaleNeuroimage19999931269Yes
199715071507.045.1745.2Signal transduction by reactive oxygen species. Toren FinkelJ Cell Biol201121746850No
199830121506.058.9829.5Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. P J Mitchell, R TjianScience19892667136No
199930101505.0107.9154.0The M1 and M2 paradigm of macrophage activation: time for reassessment. Fernando O Martinez, Siamon GordonF1000Prime Rep201424669294No
200030071503.579.5439.8Materials for electrochemical capacitors. Patrice Simon, Yury GogotsiNat Mater200818956000Yes
200130061503.086.2343.1What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. J Zhang, K F YuJAMA19989832001Yes
200230061503.057.4428.7Missing pieces in the NF-kappaB puzzle. Sankar Ghosh, Michael KarinCell200211983155No
200315031503.033.6333.6The molecular logic of endocannabinoid signalling. Daniele PiomelliNat Rev Neurosci200314595399No
200415021502.051.5651.6Lyme disease. A C SteereN Engl J Med19892668764No
200515021502.047.9147.9Health consequences of obesity in youth: childhood predictors of adult disease. W H DietzPediatrics199812224658No
200615021502.059.0159.0Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement. Virginia A MoyerAnn Intern Med201424378917No
200730031501.586.7843.4Accessories to the crime: functions of cells recruited to the tumor microenvironment. Douglas Hanahan, Lisa M CoussensCancer Cell201222439926No
200815011501.034.1634.2Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J C UnkelessJ Exp Med197990108Yes
200930021501.067.7333.9The DNA damage response: making it safe to play with knives. Alberto Ciccia, Stephen J ElledgeMol Cell201020965415No
201030011500.589.7744.9Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. P J Basser, C PierpaoliJ Magn Reson B19968661285Yes
201115001500.040.3340.3Rheumatoid arthritis. Pathophysiology and implications for therapy. E D HarrisN Engl J Med19902271017No
201215001500.031.6131.6Cancer epigenomics: DNA methylomes and histone-modification maps. Manel EstellerNat Rev Genet200717339880No
201329991499.588.9744.5Extended-connectivity fingerprints. David Rogers, Mathew HahnJ Chem Inf Model201020426451Yes
201444981499.3126.942.3The fusiform face area: a module in human extrastriate cortex specialized for face perception. N Kanwisher, J McDermott, M M ChunJ Neurosci19979151747Yes
201529981499.078.7539.4Lipid rafts as a membrane-organizing principle. Daniel Lingwood, Kai SimonsScience201020044567No
201614981498.042.7442.7Isolated removal of hypothalamic or other brain nuclei of the rat. M PalkovitsBrain Res19734747772Yes
201714971497.033.6833.7Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. M B LuskinNeuron19938338665Yes
201889811496.8282.847.1TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L SalzbergGenome Biol201323618408Yes
201929931496.50.00.0Lactic dehydrogenase activity in blood. F Wroblewski, J S LadueProc Soc Exp Biol Med195513273400Yes
202029921496.0176.2188.1Rating systems in the evaluation of knee ligament injuries. Y Tegner, J LysholmClin Orthop Relat Res19854028566Yes
202114961496.032.9933.0Hyaluronan: from extracellular glue to pericellular cue. Bryan P TooleNat Rev Cancer200415229478No
202214951495.00.00.0The colorimetric determination of phosphorus. E J KingBiochem J193216744823Yes
202314941494.039.0639.1The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. A S FauciScience19883277274No
202429881494.088.3944.2Porosity of 3D biomaterial scaffolds and osteogenesis. Vassilis Karageorgiou, David KaplanBiomaterials200515860204No
202514931493.033.1333.1Tumor suppressor genes. R A WeinbergScience19911659741No
202629861493.060.330.1Chemokines: a new classification system and their role in immunity. A Zlotnik, O YoshieImmunity200010714678No
202714921492.037.1137.1Reconciling the chemistry and biology of reactive oxygen species. Christine C WinterbournNat Chem Biol200818421291No
202829831491.50.00.0Mutations of Bacteria from Virus Sensitivity to Virus Resistance. S E Luria, M DelbrückGenetics194317247100Yes
202914911491.029.7229.7Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. S AvrameasImmunochemistry19694975324Yes
203044731491.0120.7940.3I-TASSER: a unified platform for automated protein structure and function prediction. Ambrish Roy, Alper Kucukural, Yang ZhangNat Protoc201020360767Yes
203114891489.033.1633.2Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. C TaswellJ Immunol19817009746Yes
203214891489.039.8239.8Redox signaling: nitrosylation and related target interactions of nitric oxide. J S StamlerCell19947923362No
203329781489.065.9733.0How matrix metalloproteinases regulate cell behavior. M D Sternlicht, Z WerbAnnu Rev Cell Dev Biol200111687497No
203414881488.058.4358.4MorphoJ: an integrated software package for geometric morphometrics. Christian Peter KlingenbergMol Ecol Resour201121429143Yes
203514871487.036.9136.9An economic method for the fluorescent labeling of PCR fragments. M SchuelkeNat Biotechnol200010657137Yes
203629741487.091.7945.9LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. Roman A Laskowski, Mark B SwindellsJ Chem Inf Model201121919503Yes
203714861486.019.9920.0The mechanism of muscular contraction. H E HuxleyScience19694181952No
203814861486.021.5221.5Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. J W OlneyScience19695778021Yes
203914861486.046.1946.2Polycystic ovary syndrome. S FranksN Engl J Med19957651477No
204014861486.026.026.0Histone acetylation and transcriptional regulatory mechanisms. K StruhlGenes Dev19989499396No
204114851485.041.1541.1Emotion regulation: affective, cognitive, and social consequences. James J GrossPsychophysiology200212212647No
204214851485.048.5148.5The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. Poul Erik PetersenCommunity Dent Oral Epidemiol200315015736Yes
204314851485.032.0132.0Critical period plasticity in local cortical circuits. Takao K HenschNat Rev Neurosci200516261181No
204414841484.042.9843.0Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. M D MainesFASEB J19883290025No
204514841484.049.8249.8The measurement of psychological androgyny. S L BemJ Consult Clin Psychol19744823550Yes
204614841484.040.6940.7Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. J A BeavoPhysiol Rev19957480160No
204714841484.047.8447.8SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. B P O'ConnorBehav Res Methods Instrum Comput200011029811Yes
204829671483.564.1532.1Escaping free-energy minima. Alessandro Laio, Michele ParrinelloProc Natl Acad Sci U S A200212271136Yes
2049192791483.0502.1238.6Clustal W and Clustal X version 2.0. M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G HigginsBioinformatics200717846036Yes
205029651482.564.5832.3Cellular senescence: when bad things happen to good cells. Judith Campisi, Fabrizio d'Adda di FagagnaNat Rev Mol Cell Biol200717667954No
205114821482.033.6733.7Defective repair replication of DNA in xeroderma pigmentosum. J E CleaverNature19685655953Yes
205214821482.05.685.7Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. R W SperryProc Natl Acad Sci U S A196314077501Yes
2053103721481.7221.5431.6Embryonic stem cell lines derived from human blastocysts. J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M JonesScience19989804556Yes
205429631481.599.6149.8How useful is SBF in predicting in vivo bone bioactivity? Tadashi Kokubo, Hiroaki TakadamaBiomaterials200616448693No
205514811481.045.945.9Superoxide dismutases. I FridovichAnnu Rev Biochem19751094908No
205644421480.7108.8436.3Membrane lipids: where they are and how they behave. Gerrit van Meer, Dennis R Voelker, Gerald W FeigensonNat Rev Mol Cell Biol200818216768No
205729611480.582.2441.1Genome regulation by long noncoding RNAs. John L Rinn, Howard Y ChangAnnu Rev Biochem201222663078No
205888821480.3209.0834.8Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O LötvallNat Cell Biol200717486113Yes
205914801480.065.465.4Human agency in social cognitive theory. A BanduraAm Psychol19892782727Yes
206014801480.030.7330.7Ionic blockage of sodium channels in nerve. A M WoodhullJ Gen Physiol19734541078Yes
206114801480.035.1935.2Neuronal synchrony: a versatile code for the definition of relations? W SingerNeuron199910677026No
206244391479.7114.7338.2How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. R M Sapolsky, L M Romero, A U MunckEndocr Rev200010696570No
206329581479.076.6838.3The expanding universe of T-cell subsets: Th1, Th2 and more. T R Mosmann, S SadImmunol Today19968820272No
206414791479.032.5632.6The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. S E KahnDiabetologia200312637977No
206514781478.033.8433.8The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. M TakeichiDevelopment19883048970No
206659081477.0243.3460.8A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. M A Markwell, S M Haas, L L Bieber, N E TolbertAnal Biochem197898070Yes
206714771477.026.1326.1R factor transfer in Rhizobium leguminosarum. J E BeringerJ Gen Microbiol19744612098Yes
206814771477.034.7434.7Oxidative stress in Parkinson's disease. Peter JennerAnn Neurol200312666096No
206944311477.074.0324.7Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. C A Winter, E A Risley, G W NussProc Soc Exp Biol Med196214001233Yes
207014771477.042.9543.0Mitochondria and cancer. Douglas C WallaceNat Rev Cancer201223001348No
207129521476.0115.9658.0Assessment of eating disorders: interview or self-report questionnaire? C G Fairburn, S J BeglinInt J Eat Disord19947866415Yes
207214761476.039.7639.8A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. J EngelEpilepsia200111422340Yes
207344271475.732.5810.9The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. J T Dodge, C Mitchell, D J HanahanArch Biochem Biophys196314028302Yes
207488511475.2261.2643.5Cancer statistics, 2009. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J ThunCA Cancer J Clin200919474385Yes
207514751475.064.4764.5Derivation and validation of a short-form oral health impact profile. G D SladeCommunity Dent Oral Epidemiol19979332805Yes
207614751475.048.0748.1Inflammation in atherosclerosis. Peter LibbyArterioscler Thromb Vasc Biol201222895665No
207714741474.024.9124.9Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. K FuxeActa Physiol Scand Suppl196514319769Yes
207829471473.577.5938.8A general method for isolation of high molecular weight DNA from eukaryotes. N Blin, D W StaffordNucleic Acids Res1976987581Yes
207929471473.576.4938.2Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. Gerard Talavera, Jose CastresanaSyst Biol200717654362Yes
208014711471.070.5470.5Chronic illness as biographical disruption. M BurySociol Health Illn198210260456Yes
208114711471.038.5338.5Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Michael F HolickAm J Clin Nutr200415585788No
208244111470.3153.7451.2CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Teresa C Horan, Mary Andrus, Margaret A DudeckAm J Infect Control200818538699No
208314701470.037.1437.1Interoception: the sense of the physiological condition of the body. A D CraigCurr Opin Neurobiol200312965300No
208414691469.045.6745.7The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. J L CummingsNeurology19979153155No
208514691469.07.647.6Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. H E HuxleyJ Mol Biol196314064165Yes
208629371468.574.9837.5Abdominal obesity and metabolic syndrome. Jean-Pierre Després, Isabelle LemieuxNature200617167477No
208744021467.392.9731.0TOR signaling in growth and metabolism. Stephan Wullschleger, Robbie Loewith, Michael N HallCell200616469695No
2088132041467.1405.1345.0The 1982 revised criteria for the classification of systemic lupus erythematosus. E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J WinchesterArthritis Rheum19827138600Yes
208914671467.033.3833.4Simple methods for "staining with lead" at high pH in electron microscopy. M J KarnovskyJ Biophys Biochem Cytol196114454024Yes
209014671467.036.0836.1Fast and robust fixed-point algorithms for independent component analysis. A HyvärinenIEEE Trans Neural Netw199918252563Yes
209114661466.031.1531.1Topoisomerase I inhibitors: camptothecins and beyond. Yves PommierNat Rev Cancer200616990856No
209243971465.7265.8688.6SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Antoine Daina, Olivier Michielin, Vincent ZoeteSci Rep201728256516Yes
209314651465.00.00.0Modality and topographic properties of single neurons of cat's somatic sensory cortex. V B MountcastleJ Neurophysiol195713439410Yes
209414651465.00.00.0The free amino groups of insulin. F SangerBiochem J194516747948Yes
209529281464.0456.21228.1Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation. Ivica Letunic, Peer BorkNucleic Acids Res202133885785Yes
209629271463.591.6645.8Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Riccardo Lencioni, Josep M LlovetSemin Liver Dis201020175033No
209714631463.033.9433.9PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. B M SpiegelmanDiabetes19989568680No
209858521463.0128.1932.0Probability-based protein identification by searching sequence databases using mass spectrometry data. D N Perkins, D J Pappin, D M Creasy, J S CottrellElectrophoresis199910612281Yes
209914631463.031.4931.5Autophagy: from phenomenology to molecular understanding in less than a decade. Daniel J KlionskyNat Rev Mol Cell Biol200717712358No
210014621462.045.1545.1Equipoise and the ethics of clinical research. B FreedmanN Engl J Med19873600702Yes
210129241462.086.3543.2From best evidence to best practice: effective implementation of change in patients' care. Richard Grol, Jeremy GrimshawLancet200314568747No
210214621462.00.00.0Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. I E BushBiochem J195214915960Yes
210314621462.040.1440.1Leishmaniasis: current situation and new perspectives. P DesjeuxComp Immunol Microbiol Infect Dis200415225981No
210429221461.038.8619.4The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. E G Gray, V P WhittakerJ Anat196213901297Yes
210514611461.00.00.0The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. O V BatsonAnn Surg194017857618Yes
210614611461.073.1373.1Neutrophil extracellular traps in immunity and disease. Venizelos PapayannopoulosNat Rev Immunol201828990587No
210714601460.034.4334.4Binary Agrobacterium vectors for plant transformation. M BevanNucleic Acids Res19846095209Yes
210814591459.036.0336.0Microbial ecology of the gastrointestinal tract. D C SavageAnnu Rev Microbiol1977334036No
210914581458.028.9729.0The organization of proteins in the human red blood cell membrane. A review. T L SteckJ Cell Biol19744600883No
211014581458.026.6426.6The Relation Of Recombination To Mutational Advance. H J MullerMutat Res196414195748Yes
211129141457.00.00.0Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. D H Clarke, J CasalsAm J Trop Med Hyg195813571577Yes
211229141457.085.8442.9The cortical organization of speech processing. Gregory Hickok, David PoeppelNat Rev Neurosci200717431404No
211314561456.053.9453.9Cardiac valve surgery--the "French correction". A CarpentierJ Thorac Cardiovasc Surg19836887954Yes
211414561456.033.6733.7Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. P C NowellCancer Res196014427849Yes
211529101455.099.2349.6Assay of proteins in the presence of interfering materials. A Bensadoun, D WeinsteinAnal Biochem19761259145Yes
211629091454.5113.7256.9Elements of cancer immunity and the cancer-immune set point. Daniel S Chen, Ira MellmanNature201728102259No
211714541454.019.5919.6Codon--anticodon pairing: the wobble hypothesis. F H CrickJ Mol Biol19665969078Yes
211814541454.041.2541.2The Hospital Anxiety And Depression Scale. R Philip SnaithHealth Qual Life Outcomes200312914662Yes
211914541454.00.00.0A modified ninhydrin colorimetric analysis for amino acids. H RosenArch Biochem Biophys195713412116Yes
212014541454.032.9833.0Cell signaling. H2O2, a necessary evil for cell signaling. Sue Goo RheeScience200616809515Yes
212114541454.00.00.0Potential, Impedance, And Rectification In Membranes. D E GoldmanJ Gen Physiol194319873371Yes
212243601453.335.2611.8Improved method for the determination of blood glutathione. E Beutler, O Duron, B M KellyJ Lab Clin Med196313967893Yes
212343591453.094.9231.6Telomeres shorten during ageing of human fibroblasts. C B Harley, A B Futcher, C W GreiderNature19902342578Yes
212429061453.066.2933.1Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. C Auffray, F RougeonEur J Biochem19806772444Yes
212529061453.085.0342.5Mediation in experimental and nonexperimental studies: new procedures and recommendations. Patrick E Shrout, Niall BolgerPsychol Methods200212530702Yes
212614531453.072.3472.3International classification of sleep disorders-third edition: highlights and modifications. Michael J SateiaChest201425367475No
212743571452.3109.6236.5The metabolic syndrome. Robert H Eckel, Scott M Grundy, Paul Z ZimmetLancet200515836891No
212814521452.035.535.5General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. R A HoughtenProc Natl Acad Sci U S A19852410914Yes
212914521452.031.6631.7Protein misfolding, evolution and disease. C M DobsonTrends Biochem Sci199910470028No
213029031451.567.2833.6The MAPK signaling cascade. R Seger, E G KrebsFASEB J19957601337No
213129031451.557.8928.9Intrinsically unstructured proteins and their functions. H Jane Dyson, Peter E WrightNat Rev Mol Cell Biol200515738986No
213229031451.560.3830.2Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Joshua E Elias, Steven P GygiNat Methods200717327847Yes
213314511451.048.4348.4Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. G A McPhersonJ Pharmacol Methods19853840547Yes
213414511451.036.2636.3Stress and hippocampal plasticity. B S McEwenAnnu Rev Neurosci199910202533No
213514511451.030.4930.5Neurotrophins as synaptic modulators. M M PooNat Rev Neurosci200111253356No
213629021451.077.5438.8Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. B R Celli, W MacNeeEur Respir J200415219010No
213714511451.044.0144.0The functional gastrointestinal disorders and the Rome III process. Douglas A DrossmanGastroenterology200616678553No
213858031450.8180.3345.1The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. L A Sternberger, P H Hardy, J J Cuculis, H G MeyerJ Histochem Cytochem19704192899Yes
213929001450.090.7445.4Functional architecture of basal ganglia circuits: neural substrates of parallel processing. G E Alexander, M D CrutcherTrends Neurosci19901695401No
214029001450.074.3637.2Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. I Issemann, S GreenNature19902129546Yes
214114501450.046.1446.1A clinical method for assessing the ventilatory response to carbon dioxide. D J ReadAustralas Ann Med19676032026Yes
214243501450.0132.2144.1Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. S van der Linden, H A Valkenburg, A CatsArthritis Rheum19846231933Yes
214328991449.594.3747.2Peptidoglycan types of bacterial cell walls and their taxonomic implications. K H Schleifer, O KandlerBacteriol Rev19724568761No
214428991449.579.2939.6A rapid boiling method for the preparation of bacterial plasmids. D S Holmes, M QuigleyAnal Biochem19816269464Yes
214514491449.049.749.7Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. S KatzJ Am Geriatr Soc19836418786No
214628961448.072.0936.03' non-coding region sequences in eukaryotic messenger RNA. N J Proudfoot, G G BrownleeNature1976822353Yes
214714481448.033.5333.5Developmental cell death: morphological diversity and multiple mechanisms. P G ClarkeAnat Embryol (Berl)19902186664No
214814481448.040.7740.8Treatment of infections associated with surgical implants. Rabih O DarouicheN Engl J Med200415070792No
214914481448.036.2836.3Wound healing and its impairment in the diabetic foot. Vincent FalangaLancet200516291068No
215014481448.031.731.7Mitochondria: dynamic organelles in disease, aging, and development. David C ChanCell200616814712No
215143431447.792.6330.9NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. S Ghosh, M J May, E B KoppAnnu Rev Immunol19989597130No
215214471447.00.00.0Starch gel electrophoresis in a discontinous system of buffers. M D PoulikNature195713493570Yes
2153130161446.2400.2444.5The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C DunbarJ Clin Psychiatry19989881538No
215414461446.035.535.5The amygdala modulates the consolidation of memories of emotionally arousing experiences. James L McGaughAnnu Rev Neurosci200415217324No
2155101181445.4283.6640.5BLAST+: architecture and applications. Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L MaddenBMC Bioinformatics200920003500Yes
215614451445.042.4242.4Human cardiovascular adjustments to exercise and thermal stress. L B RowellPhysiol Rev19744587247No
215728881444.058.0529.0A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. A H Anton, D F SayreJ Pharmacol Exp Ther196214013351Yes
215828861443.0109.5754.8A new initiative on precision medicine. Francis S Collins, Harold VarmusN Engl J Med201525635347Yes
215914421442.042.3442.3Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. M Robin DiMatteoMed Care200415076819Yes
216014421442.050.3250.3Phase retrieval algorithms: a comparison. J R FienupAppl Opt198220396114Yes
216128831441.585.8742.9The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. J D Hayes, D J PulfordCrit Rev Biochem Mol Biol19958770536No
216228831441.50.00.0Mutants of Escherichia coli requiring methionine or vitamin B12. B D Davis, E S MingioliJ Bacteriol195015436457Yes
216314411441.074.2174.2The determinants of parenting: a process model. J BelskyChild Dev19846705636Yes
216414401440.037.2937.3Capacitative calcium entry revisited. J W PutneyCell Calcium19901965707No
216514391439.037.9638.0Cell and environment interactions in tumor microregions: the multicell spheroid model. R M SutherlandScience19882451290Yes
216614391439.056.8256.8An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. J Kabat-ZinnGen Hosp Psychiatry19827042457Yes
216714391439.037.6437.6The world health report 2002 - reducing risks, promoting healthy life. J J GuilbertEduc Health (Abingdon)200314741909Yes
216814391439.0117.9117.9User's guide to correlation coefficients. Haldun AkogluTurk J Emerg Med201830191186No
216928771438.594.2947.1The efficiency of systematic sampling in stereology and its prediction. H J Gundersen, E B JensenJ Microsc19873430576Yes
2170129451438.3632.5170.3Cancer statistics in China, 2015. Wanqing Chen, Rongshou Zheng, Peter D Baade, Siwei Zhang, Hongmei Zeng, Freddie Bray, Ahmedin Jemal, Xue Qin Yu, Jie HeCA Cancer J Clin201626808342Yes
217128761438.078.139.0Angiogenesis. J Folkman, Y ShingJ Biol Chem19921375931No
217214371437.056.3756.4Reliability and factor analysis of the Epworth Sleepiness Scale. M W JohnsSleep19921519015Yes
217314371437.034.6334.6Origin, biogenesis, and activity of plant microRNAs. Olivier VoinnetCell200919239888No
217428721436.060.0930.0The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. M S Brown, J L GoldsteinCell19979150132No
217514361436.029.3629.4Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. S S FergusonPharmacol Rev200111171937No
217614351435.031.4731.5DNA damage, aging, and cancer. Jan H J HoeijmakersN Engl J Med200919812404No
217714351435.059.1559.1Working memory: theories, models, and controversies. Alan BaddeleyAnnu Rev Psychol201221961947No
217828681434.091.4945.7Synchronization of Plasmodium falciparum erythrocytic stages in culture. C Lambros, J P VanderbergJ Parasitol1979383936Yes
217928681434.00.00.0Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. H J Bloom, W W RichardsonBr J Cancer195713499785Yes
2180157591432.6416.5137.9The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristoGenome Res201020644199Yes
218128651432.567.4533.7Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. H Cai, D G HarrisonCirc Res200011073878No
218228651432.50.00.0Brain stem reticular formation and activation of the EEG. G Moruzzi, H W MagounElectroencephalogr Clin Neurophysiol194918421835Yes
218314321432.034.1334.1The use of nanocrystals in biological detection. Paul AlivisatosNat Biotechnol200414704706Yes
218414321432.040.2440.2Graphene transistors. Frank SchwierzNat Nanotechnol201020512128Yes
218542951431.7100.7733.6Long non-coding RNAs: insights into functions. Tim R Mercer, Marcel E Dinger, John S MattickNat Rev Genet200919188922No
218628611430.573.236.6Molecular replacement with MOLREP. Alexei Vagin, Alexei TeplyakovActa Crystallogr D Biol Crystallogr201020057045Yes
218728591429.554.1127.1T-cell antigen receptor genes and T-cell recognition. M M Davis, P J BjorkmanNature19883043226No
218814291429.050.6750.7The prevalence of 'alexithymic' characteristics in psychosomatic patients. P E SifneosPsychother Psychosom19734770536Yes
218914291429.042.5242.5Strong localization of photons in certain disordered dielectric superlattices. S JohnPhys Rev Lett198710034761Yes
219014291429.00.00.0A new readability yardstick. R FleschJ Appl Psychol194818867058Yes
219171421428.4153.3130.7Site-directed mutagenesis by overlap extension using the polymerase chain reaction. S N Ho, H D Hunt, R M Horton, J K Pullen, L R PeaseGene19892744487Yes
219214281428.047.8147.8Gene flow and the geographic structure of natural populations. M SlatkinScience19873576198Yes
219314281428.092.1992.2The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. F DenisSpine (Phila Pa 1976)19836670016Yes
219414281428.049.6149.6Colorimetric determination of phospholipids with ammonium ferrothiocyanate. J C StewartAnal Biochem19806892980Yes
219514281428.033.3333.3Functions of ceramide in coordinating cellular responses to stress. Y A HannunScience19968943189No
219614271427.041.9742.0Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. E N BergmanPhysiol Rev19902181501No
219714271427.041.1841.2The aging process. D HarmanProc Natl Acad Sci U S A19816947277Yes
219842801426.784.0128.0The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Fabio Martinon, Kimberly Burns, Jürg TschoppMol Cell200212191486Yes
219942791426.388.129.4Toll-like receptors. Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo AkiraAnnu Rev Immunol200312524386No
220028511425.569.7234.9Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. E S Lander, D BotsteinGenetics19892563713Yes
220114251425.041.6441.6The fetal and infant origins of adult disease. D J BarkerBMJ19902252919No
220214251425.037.0137.0Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. J WymanAdv Protein Chem196414268785No
2203113961424.5283.8435.5Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M JoliotNeuroimage200211771995Yes
220414241424.043.5543.5Biological basis of the behavior of sick animals. B L HartNeurosci Biobehav Rev19883050629No
220514241424.040.840.8Recent developments in isocyanide based multicomponent reactions in applied chemistry. Alexander DömlingChem Rev200616402771No
220614231423.035.2735.3The 'effective number of codons' used in a gene. F WrightGene19902110097Yes
220714231423.026.6726.7Ubiquitin-dependent protein degradation. M HochstrasserAnnu Rev Genet19968982460No
220828451422.555.0527.5Autophagy as a regulated pathway of cellular degradation. D J Klionsky, S D EmrScience200011099404No
220942671422.3113.0937.7Fast model-based estimation of ancestry in unrelated individuals. David H Alexander, John Novembre, Kenneth LangeGenome Res200919648217Yes
221028431421.5144.7672.4A simple practice guide for dose conversion between animals and human. Anroop B Nair, Shery JacobJ Basic Clin Pharm201627057123No
221128421421.096.5148.3Selective loss of central cholinergic neurons in Alzheimer's disease. P Davies, A J MaloneyLancet197663862Yes
221214211421.051.5651.6Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. M P BlausteinAm J Physiol1977324293No
221314211421.093.3493.3The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. F C EwaldClin Orthop Relat Res19892805502Yes
221414211421.025.7225.7The DNA methyltransferases of mammals. T H BestorHum Mol Genet200011005794No
221528401420.084.3542.2Intracellular pH. A Roos, W F BoronPhysiol Rev19817012859No
221656791419.8262.9265.7Prevalence of childhood and adult obesity in the United States, 2011-2012. Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M FlegalJAMA201424570244Yes
221714191419.044.8844.9Formation of glasses from liquids and biopolymers. C A AngellScience199517770101Yes
221828371418.554.9927.5Cancer genes and the pathways they control. Bert Vogelstein, Kenneth W KinzlerNat Med200415286780No
221914181418.041.0741.1Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Charles A DinarelloBlood201121304099No
222056711417.8165.4241.4Reversible middle cerebral artery occlusion without craniectomy in rats. E Z Longa, P R Weinstein, S Carlson, R CumminsStroke19892643202Yes
222142511417.0141.0947.0Vascular endothelial cells synthesize nitric oxide from L-arginine. R M Palmer, D S Ashton, S MoncadaNature19883131684Yes
222214171417.036.0236.0Hemispheric asymmetry reduction in older adults: the HAROLD model. Roberto CabezaPsychol Aging200211931290No
222342511417.0221.373.8Radiomics: Images Are More than Pictures, They Are Data. Robert J Gillies, Paul E Kinahan, Hedvig HricakRadiology201626579733Yes
222414161416.056.5556.5Social phobia. M R LiebowitzMod Probl Pharmacopsychiatry19872885745Yes
222528321416.079.5939.8Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. F D Lublin, S C ReingoldNeurology19968780061Yes
222628321416.0119.3459.73D bioprinting of tissues and organs. Sean V Murphy, Anthony AtalaNat Biotechnol201425093879Yes
2227169831415.2714.7859.6Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Sue Richards, Nazneen Aziz, Sherri Bale, David Bick, Soma Das, Julie Gastier-Foster, Wayne W Grody, Madhuri Hegde, Elaine Lyon, Elaine Spector, Karl Voelkerding, Heidi L RehmGenet Med201525741868No
222814151415.042.8542.9Mate selection-a selection for a handicap. A ZahaviJ Theor Biol19751195756Yes
222914151415.035.3235.3Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. S S LehrerBiochemistry19715119250Yes
223014151415.033.4733.5Proinflammatory cytokines. C A DinarelloChest200010936147No
223128301415.00.00.0Virus interference. I. The interferon. A Isaacs, J LindenmannProc R Soc Lond B Biol Sci195713465720Yes
223256601415.0144.436.1Microbial ecology: human gut microbes associated with obesity. Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I GordonNature200617183309Yes
223328291414.597.0448.5The framing of decisions and the psychology of choice. A Tversky, D KahnemanScience19817455683Yes
223428291414.572.0436.0Morris water maze: procedures for assessing spatial and related forms of learning and memory. Charles V Vorhees, Michael T WilliamsNat Protoc200617406317Yes
223514141414.022.8622.9Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. K S McCullyAm J Pathol19695792556Yes
223628281414.056.4828.2Short-term synaptic plasticity. Robert S Zucker, Wade G RegehrAnnu Rev Physiol200211826273No
223714131413.026.3626.4NK cell receptors. L L LanierAnnu Rev Immunol19989597134No
223814131413.033.1933.2Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Bei-Fan ZhouBiomed Environ Sci200212046553Yes
223914131413.026.9727.0The significance of responses of the genome to challenge. B McClintockScience198415739260No
224014121412.032.1932.2Nonaqueous liquid electrolytes for lithium-based rechargeable batteries. Kang XuChem Rev200415669157Yes
224114111411.039.7139.7Isolation and cultivation of Lyme disease spirochetes. A G BarbourYale J Biol Med19846393604Yes
224228221411.00.00.0The effect of sodium ions on the electrical activity of giant axon of the squid. A L Hodgkin, B KatzJ Physiol194918128147Yes
224314111411.042.2442.2The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Artemis P SimopoulosExp Biol Med (Maywood)200818408140No
224414101410.052.0952.1Diversity in tropical rain forests and coral reefs. J H ConnellScience197817840770Yes
224528191409.567.7733.9Decision curve analysis: a novel method for evaluating prediction models. Andrew J Vickers, Elena B ElkinMed Decis Making200617099194Yes
224614091409.032.8832.9Speculations on the functions of the major heat shock and glucose-regulated proteins. H R PelhamCell19862944601Yes
224714091409.059.4459.4The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. E J KhantzianAm J Psychiatry19853904487No
224814091409.048.1348.1Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. Russell LandeEvolution197928568194Yes
224928171408.580.4940.2Empirical predictions of protein conformation. P Y Chou, G D FasmanAnnu Rev Biochem1978354496No
225014081408.033.5433.5The basic science of gene therapy. R C MulliganScience19938493530No
225128151407.571.4935.7A globally coherent fingerprint of climate change impacts across natural systems. Camille Parmesan, Gary YoheNature200312511946Yes
225228151407.5107.4653.7Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. Susan Whitfield-Gabrieli, Alfonso Nieto-CastanonBrain Connect201222642651Yes
225314071407.037.4737.5A note on robust variance estimation for cluster-correlated data. R L WilliamsBiometrics200010877330Yes
225414071407.035.8235.8The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. T SzkudelskiPhysiol Res200111829314No
225528131406.554.7527.4Wnt signalling in stem cells and cancer. Tannishtha Reya, Hans CleversNature200515829953No
225628121406.057.5928.8'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? George Davey Smith, Shah EbrahimInt J Epidemiol200312689998No
225728111405.552.2126.1Oncogenic kinase signalling. P Blume-Jensen, T HunterNature200111357143No
225828101405.077.1538.6Transforming growth factor beta in tissue fibrosis. W A Border, N A NobleN Engl J Med19947935686No
225914041404.025.525.5Selection of successive tumour lines for metastasis. I J FidlerNat New Biol19734512654Yes
226014041404.061.3161.3A New Weighting System For Mean Surface Temperature Of The Human Body. N L RamanathanJ Appl Physiol196414173555Yes
226142121404.0121.0940.4Dose translation from animal to human studies revisited. Shannon Reagan-Shaw, Minakshi Nihal, Nihal AhmadFASEB J200817942826Yes
226242101403.3146.3248.8Structure-antioxidant activity relationships of flavonoids and phenolic acids. C A Rice-Evans, N J Miller, G PagangaFree Radic Biol Med19968743980Yes
226328061403.087.7543.9Performing the exact test of Hardy-Weinberg proportion for multiple alleles. S W Guo, E A ThompsonBiometrics19921637966Yes
226414031403.035.2635.3Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. Y ShaiBiochim Biophys Acta199910590302No
226514031403.036.6936.7The epidemiology of venous thromboembolism. Richard H WhiteCirculation200312814979No
226614031403.050.4350.4Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. T Florian JaegerJ Mem Lang200819884961Yes
226728051402.569.6434.8Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. M D Pierschbacher, E RuoslahtiNature19846325925Yes
226814021402.045.9345.9Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. N KriegerAm J Public Health19921566949Yes
226914021402.036.0436.0The intraclass correlation coefficient as a measure of reliability. J J BartkoPsychol Rep19665942109Yes
227028041402.072.4836.2Alternative activation of macrophages: mechanism and functions. Siamon Gordon, Fernando O MartinezImmunity201020510870No
227114021402.040.6540.6Breakthrough of the year 2013. Cancer immunotherapy. Jennifer Couzin-FrankelScience201324357284No
227228031401.562.4931.2Raster3D Version 2.0. A program for photorealistic molecular graphics. E A Merritt, M E MurphyActa Crystallogr D Biol Crystallogr199415299354Yes
227356051401.2155.4938.9Image quality assessment: from error visibility to structural similarity. Zhou Wang, Alan Conrad Bovik, Hamid Rahim Sheikh, Eero P SimoncelliIEEE Trans Image Process200415376593Yes
227428021401.071.0735.5CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. D G Higgins, P M SharpGene19883243435Yes
227514011401.038.9338.9The debate over dopamine's role in reward: the case for incentive salience. Kent C BerridgePsychopharmacology (Berl)200717072591No
227628011400.542.1421.1Prediction of protein conformation. P Y Chou, G D FasmanBiochemistry19744358940Yes
227714001400.032.0432.0Protein kinase C: structure, function, and regulation. A C NewtonJ Biol Chem19957499357No
227841991399.785.2928.4Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Michael J Rust, Mark Bates, Xiaowei ZhuangNat Methods200616896339Yes
227927991399.561.5930.8An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. A A Beg, D BaltimoreScience19968864118Yes
228013991399.062.5362.5Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. P de LevaJ Biomech19968872282Yes
228113981398.050.3150.3The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. A RaineSchizophr Bull19911805349Yes
228227961398.069.7934.9Molecular beacons: probes that fluoresce upon hybridization. S Tyagi, F R KramerNat Biotechnol19969630890Yes
228327951397.561.9331.0The pathophysiology and treatment of sepsis. Richard S Hotchkiss, Irene E KarlN Engl J Med200312519925No
228483821397.0215.2235.9Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur WheelerN Engl J Med200010793162Yes
228513971397.060.6460.6Periodontitis: from microbial immune subversion to systemic inflammation. George HajishengallisNat Rev Immunol201525534621No
228627931396.5121.0960.5Sex differences in immune responses. Sabra L Klein, Katie L FlanaganNat Rev Immunol201627546235No
228713961396.028.0528.1The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. R C LewontinGenetics196417248194Yes
228827891394.582.5441.3Glycine potentiates the NMDA response in cultured mouse brain neurons. J W Johnson, P AscherNature19872433595Yes
228927891394.588.7444.4Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. Johan W S Vlaeyen, Steven J LintonPain200010781906No
229027881394.086.2843.1Unidentified curved bacilli on gastric epithelium in active chronic gastritis. J R Warren, B MarshallLancet19836134060Yes
229113941394.030.5730.6The ATP synthase--a splendid molecular machine. P D BoyerAnnu Rev Biochem19979242922No
229213941394.033.3733.4Drug-induced prolongation of the QT interval. Dan M RodenN Engl J Med200414999113No
229327851392.582.2841.1Microdetermination of long-chain fatty acids in plasma and tissues. V P Dole, H MeinertzJ Biol Chem196013817286Yes
229427841392.072.8636.4Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. E Engvall, P PerlmannImmunochemistry19715135623Yes
229513921392.052.7952.8Presidential address, 1980. Surprise!...Surprise? E DonchinPsychophysiology19817280146Yes
229613921392.024.1824.2The economics of ribosome biosynthesis in yeast. J R WarnerTrends Biochem Sci199910542411No
229727841392.0110.7855.4Cisplatin in cancer therapy: molecular mechanisms of action. Shaloam Dasari, Paul Bernard TchounwouEur J Pharmacol201425058905No
229827821391.0149.1274.6Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. L F Berkman, S L SymeAm J Epidemiol1979425958Yes
229913911391.050.1150.1Quantitative methods in the review of epidemiologic literature. S GreenlandEpidemiol Rev19873678409Yes
230013911391.027.0427.0Natively unfolded proteins: a point where biology waits for physics. Vladimir N UverskyProtein Sci200211910019No
230113891389.029.629.6Cancer of the ovary. Stephen A CannistraN Engl J Med200415590954No
230227771388.584.3242.2An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. O Johnell, J A KanisOsteoporos Int200616983459Yes
230327761388.080.3340.2CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. Mattias Jakobsson, Noah A RosenbergBioinformatics200717485429Yes
230441631387.7100.3633.5Wnt/beta-catenin signaling: components, mechanisms, and diseases. Bryan T MacDonald, Keiko Tamai, Xi HeDev Cell200919619488No
230513871387.028.328.3Origin of concatemeric T7 DNA. J D WatsonNat New Biol19724507727Yes
230627731386.588.6944.3The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. W R Gibb, A J LeesJ Neurol Neurosurg Psychiatry19882841426No
230727731386.563.531.8A method of trace iodination of proteins for immunologic studies. P J McConahey, F J DixonInt Arch Allergy Appl Immunol19664160044Yes
230827731386.565.5432.8Inflammation, stress, and diabetes. Kathryn E Wellen, Gökhan S HotamisligilJ Clin Invest200515864338No
230913861386.033.7733.8Tobacco smoke carcinogens and lung cancer. S S HechtJ Natl Cancer Inst199910413421No
231027721386.062.1531.1Immunoassay of endogenous plasma insulin in man. R S Yalow, S A BersonJ Clin Invest196013846364Yes
231113861386.034.6534.6The cancer stem cell: premises, promises and challenges. Hans CleversNat Med201121386835No
231227721386.068.9634.5Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. Felix Krueger, Simon R AndrewsBioinformatics201121493656Yes
231313861386.062.762.7Mechanisms linking social ties and support to physical and mental health. Peggy A ThoitsJ Health Soc Behav201121673143No
231427711385.571.3435.7A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. J Messing, J VieiraGene19826295880Yes
231513851385.030.1230.1Target-oriented and diversity-oriented organic synthesis in drug discovery. S L SchreiberScience200010720315No
231641551385.0120.1640.1Validation of the Insomnia Severity Index as an outcome measure for insomnia research. C H. Bastien, A Vallières, C M. MorinSleep Med200111438246Yes
231741531384.3194.1864.7Risk factors for falls among elderly persons living in the community. M E Tinetti, M Speechley, S F GinterN Engl J Med19883205267Yes
231813841384.035.0535.0Diagnosis of osteoporosis and assessment of fracture risk. John A KanisLancet200212057569No
231955361384.0204.3651.1FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs SchoffelenComput Intell Neurosci201121253357Yes
232041511383.7111.237.1TCS: a computer program to estimate gene genealogies. M Clement, D Posada, K A CrandallMol Ecol200011050560Yes
232113831383.046.546.5Interleukin-1. C A DinarelloRev Infect Dis19846369481No
232241491383.087.7929.3Multidrug resistance in cancer: role of ATP-dependent transporters. Michael M Gottesman, Tito Fojo, Susan E BatesNat Rev Cancer200211902585No
232327661383.067.2233.6Powering the planet: chemical challenges in solar energy utilization. Nathan S Lewis, Daniel G NoceraProc Natl Acad Sci U S A200617043226Yes
232413821382.00.00.0Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. W C SchneiderJ Biol Chem194818886166Yes
232513811381.018.718.7Hippocampal electrical activity and voluntary movement in the rat. C H VanderwolfElectroencephalogr Clin Neurophysiol19694183562Yes
232613811381.031.1631.2Molecular basis of long-term plasticity underlying addiction. E J NestlerNat Rev Neurosci200111252991No
232741391379.783.7327.9The versatility and universality of calcium signalling. M J Berridge, P Lipp, M D BootmanNat Rev Mol Cell Biol200011413485No
232813791379.030.6230.6Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. M KozakMicrobiol Rev19836343825No
232913791379.035.9435.9Genetic consequences of climatic oscillations in the Quaternary. G M HewittPhilos Trans R Soc Lond B Biol Sci200415101575No
233013791379.044.1744.2The role of autophagy in neurodegenerative disease. Ralph A NixonNat Med201323921753No
233127571378.580.8240.4Physiological time-series analysis using approximate entropy and sample entropy. J S Richman, J R MoormanAm J Physiol Heart Circ Physiol200010843903Yes
233213781378.058.8358.8Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. T SpectorAnal Biochem1978655375Yes
233368901378.0254.7450.9Evidence based medicine: what it is and what it isn't. D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S RichardsonBMJ19968555924No
233427561378.080.0140.0Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. C J Murray, A D LopezLancet19979164317Yes
233513771377.029.3129.3A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Dale R NyholtAm J Hum Genet200414997420Yes
233627531376.595.2447.6A new scale of social desirability independent of psychopathology. D P Crowne, D MarloweJ Consult Psychol196013813058Yes
233741281376.0136.5245.5Global estimates of the prevalence of diabetes for 2010 and 2030. J E Shaw, R A Sicree, P Z ZimmetDiabetes Res Clin Pract201019896746Yes
233827521376.0109.3754.7Natural products as sources of new drugs over the 30 years from 1981 to 2010. David J Newman, Gordon M CraggJ Nat Prod201222316239No
233941271375.7140.4846.8Factor structure of the Barratt impulsiveness scale. J H Patton, M S Stanford, E S BarrattJ Clin Psychol19958778124Yes
234027511375.599.2649.6Biology of disease: free radicals and tissue injury. B A Freeman, J D CrapoLab Invest19826290784No
234141261375.398.3232.8Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Daniel Falush, Matthew Stephens, Jonathan K PritchardGenetics200312930761Yes
234241261375.391.9530.7OrthoMCL: identification of ortholog groups for eukaryotic genomes. Li Li, Christian J Stoeckert, David S RoosGenome Res200312952885Yes
234313751375.024.3324.3The snail superfamily of zinc-finger transcription factors. M Angela NietoNat Rev Mol Cell Biol200211994736No
234413741374.021.7821.8Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. J R DavidProc Natl Acad Sci U S A19665229858Yes
234527481374.070.3235.2Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. D Marion, K WüthrichBiochem Biophys Res Commun19836307308Yes
234613731373.028.3428.3Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. R I MorimotoGenes Dev19989869631No
234727461373.073.7436.9Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Robert E W Hancock, Hans-Georg SahlNat Biotechnol200617160061No
234813731373.057.0357.0The global burden of IBD: from 2015 to 2025. Gilaad G KaplanNat Rev Gastroenterol Hepatol201526323879No
234954911372.8211.8153.0Bayesian phylogenetics with BEAUti and the BEAST 1.7. Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew RambautMol Biol Evol201222367748Yes
235082331372.2269.8345.0Antioxidant activity applying an improved ABTS radical cation decolorization assay. R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-EvansFree Radic Biol Med199910381194Yes
235113721372.039.1139.1Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. P WillnerPsychopharmacology (Berl)19979452163No
235213721372.00.00.0An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. O SmithiesBiochem J195913638269Yes
235313721372.035.2835.3The human orbitofrontal cortex: linking reward to hedonic experience. Morten L KringelbachNat Rev Neurosci200516136173No
235413721372.043.5543.5Amino acids: metabolism, functions, and nutrition. Guoyao WuAmino Acids200919301095No
235527431371.555.2227.6Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. A J Berk, P A SharpCell1977922889Yes
235627421371.077.3238.7Mortality by cause for eight regions of the world: Global Burden of Disease Study. C J Murray, A D LopezLancet19979142060Yes
235713711371.031.9531.9Huntington's disease. Francis O WalkerLancet200717240289No
235813701370.042.4342.4The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. L W SwansonBrain Res Bull19826816390Yes
235913701370.032.2132.2Regulation of differentiation of vascular smooth muscle cells. G K OwensPhysiol Rev19957624392No
236013701370.00.00.0The generalisation of student's problems when several different population variances are involved. B L WelchBiometrika194720287819Yes
236141091369.7117.9539.3Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Garnier, D J Osguthorpe, B RobsonJ Mol Biol1978642007Yes
236213691369.039.8839.9Depression in late life: review and commentary. Dan G BlazerJ Gerontol A Biol Sci Med Sci200312634292No
236313691369.054.154.1AliView: a fast and lightweight alignment viewer and editor for large datasets. Anders LarssonBioinformatics201425095880Yes
236413681368.047.0147.0Multiple calcium channels and neuronal function. R J MillerScience19872432656No
236513681368.025.9225.9Epithelial-mesenchymal transitions in development and pathologies. Jean Paul ThieryCurr Opin Cell Biol200314644200No
236627351367.567.8733.9Myocardial reperfusion injury. Derek M Yellon, Derek J HausenloyN Engl J Med200717855673No
236727341367.085.1842.6A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. R L Juliano, V LingBiochim Biophys Acta1976990323Yes
236827341367.070.9335.5EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. Stefan Stoll, Arthur SchweigerJ Magn Reson200616188474Yes
236913671367.044.2244.2Synopsis of some recent tactical application of bioisosteres in drug design. Nicholas A MeanwellJ Med Chem201121413808Yes
237013671367.064.9164.9PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors. Anthony L SpekActa Crystallogr C Struct Chem201525567569Yes
237168331366.6198.4639.7Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939839Yes
237227331366.593.1846.6Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. D H Figurski, D R HelinskiProc Natl Acad Sci U S A1979377280Yes
237327311365.581.740.9Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. D Filmer, L H PritchettDemography200111227840Yes
237413651365.022.3322.3Cancer. Addiction to oncogenes--the Achilles heal of cancer. I Bernard WeinsteinScience200212098689No
237513651365.037.3137.3The pollution of the marine environment by plastic debris: a review. José G B DerraikMar Pollut Bull200212405208No
237627281364.072.9936.5Antibiotic resistance of bacteria in biofilms. P S Stewart, J W CostertonLancet200111463434No
237713641364.048.9248.9The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. Eleonore FröhlichInt J Nanomedicine201223144561No
237813631363.049.6349.6The structure of beta-lactamases. R P AmblerPhilos Trans R Soc Lond B Biol Sci19806109327Yes
237913631363.00.00.0Effects of varying the vehicle for OsO4 in tissue fixation. J B CaulfieldJ Biophys Biochem Cytol195713475399Yes
238027231361.580.1140.1The Measurement Of Selection On Correlated Characters. Russell Lande, Stevan J ArnoldEvolution198328556011Yes
238113611361.032.7532.8Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. G von HeijneJ Mol Biol19921593632Yes
238213611361.064.4464.4Molecular pathology of schizophrenia: more than one disease process? T J CrowBr Med J19806101544No
238313611361.028.0428.0Stability and flexibility of epigenetic gene regulation in mammalian development. Wolf ReikNature200717522676No
238413611361.041.041.0Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. Chao-Jun LiAcc Chem Res200919220064Yes
238527211360.552.2226.1A protein sequenator. P Edman, G BeggEur J Biochem19676059350Yes
238627201360.054.0227.0Prediction of complete gene structures in human genomic DNA. C Burge, S KarlinJ Mol Biol19979149143Yes
238727201360.057.8128.9LTP and LTD: an embarrassment of riches. Robert C Malenka, Mark F BearNeuron200415450156No
238813601360.034.2834.3Mitochondrial fusion and fission in cell life and death. Benedikt WestermannNat Rev Mol Cell Biol201021102612No
238927191359.595.5347.8A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. C M Tsai, C E FraschAnal Biochem19826176137Yes
239027181359.074.837.4miRBase: integrating microRNA annotation and deep-sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201121037258Yes
239127161358.062.5631.3NF-kappa B: ten years after. P A Baeuerle, D BaltimoreCell19968858144No
239213581358.031.2631.3Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? Rui WangFASEB J200212409322Yes
239313581358.012.112.1Immunological function of the thymus. J F MillerLancet196114474038Yes
239413571357.027.1627.2Dimerization of cell surface receptors in signal transduction. C H HeldinCell19957834741No
239527141357.055.3427.7Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. J M Kyriakis, J AvruchPhysiol Rev200111274345No
239613571357.035.8635.9Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. P LipsEndocr Rev200111493580No
239713571357.024.224.2Chromatin modification and epigenetic reprogramming in mammalian development. En LiNat Rev Genet200212209141No
239827141357.00.00.0The respiratory chain and oxidative phosphorylation. B Chance, G R WilliamsAdv Enzymol Relat Subj Biochem195613313307Yes
239913561356.029.9730.0Diarylethenes for Memories and Switches. Masahiro IrieChem Rev200011777416Yes
240027111355.566.3833.2Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. M P Lutolf, J A HubbellNat Biotechnol200515637621No
240113551355.052.8652.9Blood gas calculator. J W SeveringhausJ Appl Physiol19665912737Yes
240213551355.042.7742.8Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. J J GrossJ Pers Soc Psychol19989457784Yes
240340631354.390.8230.3Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. Christian W Tornøe, Caspar Christensen, Morten MeldalJ Org Chem200211975567Yes
240413541354.042.942.9Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. A A GraceNeuroscience19911676137No
240513541354.026.1826.2The origin of the genetic code. F H CrickJ Mol Biol19684887876Yes
240627081354.062.5131.3Emerging roles of caspase-3 in apoptosis. A G Porter, R U JänickeCell Death Differ199910200555No
240767661353.2165.033.0Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory CollinsLancet200212493255Yes
240813531353.034.6234.6The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. R G KhalifahJ Biol Chem19714994926Yes
240913531353.043.3843.4History of the Rochester Epidemiology Project. L J MeltonMayo Clin Proc19968594285No
241013531353.00.00.0Notes on continuous stochastic phenomena. P A P MoranBiometrika195015420245Yes
241127051352.558.9329.5NMR View: A computer program for the visualization and analysis of NMR data. B A Johnson, R A BlevinsJ Biomol NMR199422911360Yes
241240561352.035.9312.0Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. D D Sabatini, K Bensch, R J BarrnettJ Cell Biol196313975866Yes
241327031351.567.533.8The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Clay B Holroyd, Michael G H ColesPsychol Rev200212374324Yes
241413511351.041.1541.1Neurotransmitters and neuromodulators in the basal ganglia. A M GraybielTrends Neurosci19901695398No
241581061351.0203.1333.9A default mode of brain function. M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L ShulmanProc Natl Acad Sci U S A200111209064Yes
241627011350.5125.0262.5Glutathione peroxidase activity in selenium-deficient rat liver. R A Lawrence, R F BurkBiochem Biophys Res Commun1976971321Yes
241754001350.0127.5531.9The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten SchwedeBioinformatics200616301204Yes
241813501350.00.00.0An approximate distribution of estimates of variance components. F E SatterthwaiteBiometrics194620287815Yes
241926991349.561.1530.6Disruption of epithelial cell-matrix interactions induces apoptosis. S M Frisch, H FrancisJ Cell Biol19948106557Yes
242013491349.042.3642.4Glutathione metabolism and its selective modification. A MeisterJ Biol Chem19883053703No
242113491349.036.3236.3Atopic dermatitis. Thomas BieberN Engl J Med200818385500Yes
242253941348.5124.5531.1Quantitative monitoring of gene expression patterns with a complementary DNA microarray. M Schena, D Shalon, R W Davis, P O BrownScience19957569999Yes
242313481348.035.5835.6Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. S L FriedmanN Engl J Med19938502273No
242440431347.7104.234.7Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Robert D Schreiber, Lloyd J Old, Mark J SmythScience201121436444No
242513471347.042.1142.1Renin-angiotensin system: biochemistry and mechanisms of action. M J PeachPhysiol Rev1977191856No
242613471347.028.1128.1Stereological principles for morphometry in electron microscopic cytology. E R WeibelInt Rev Cytol19694899604No
242713471347.0140.18140.2A Review of Coronavirus Disease-2019 (COVID-19). Tanu SinghalIndian J Pediatr202032166607No
242826931346.564.9232.5Regulation mechanisms and signaling pathways of autophagy. Congcong He, Daniel J KlionskyAnnu Rev Genet200919653858No
242926921346.061.630.8The RXR heterodimers and orphan receptors. D J Mangelsdorf, R M EvansCell19958521508No
243013461346.033.7233.7A molecular view of microbial diversity and the biosphere. N R PaceScience19979115194No
243113461346.028.4928.5HIF-1: mediator of physiological and pathophysiological responses to hypoxia. G L SemenzaJ Appl Physiol (1985)200010749844No
243226921346.075.5737.8Epidemiology of invasive candidiasis: a persistent public health problem. M A Pfaller, D J DiekemaClin Microbiol Rev200717223626No
243326911345.565.8432.9The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Daniel J Drucker, Michael A NauckLancet200617098089No
243413451345.026.0526.1Chromosomal translocations in human cancer. T H RabbittsNature19947969446No
243526881344.090.6745.3Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. G J Miller, N E MillerLancet197546338Yes
243613441344.045.1945.2Functional organization of central pathways regulating the cardiovascular system. R A DampneyPhysiol Rev19948171117No
243740321344.0115.638.5A rapid bootstrap algorithm for the RAxML Web servers. Alexandros Stamatakis, Paul Hoover, Jacques RougemontSyst Biol200818853362Yes
243826861343.061.5430.8Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. G Blobel, B DobbersteinJ Cell Biol1975811671Yes
243913431343.039.0739.1Osteoblast adhesion on biomaterials. K AnselmeBiomaterials200010711964No
244080551342.5239.4339.9The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gøtzsche, Jan P VandenbrouckeLancet200718064739Yes
244113421342.033.2433.2The biologic clock: the mitochondria? D HarmanJ Am Geriatr Soc19725016631Yes
244213421342.042.2242.2The phenomenon of the acute phase response. I KushnerAnn N Y Acad Sci19827046585No
244326831341.575.4237.7The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. W L Jorgensen, J Tirado-RivesJ Am Chem Soc198827557051Yes
244426821341.078.8939.4A cognitive model of posttraumatic stress disorder. A Ehlers, D M ClarkBehav Res Ther200010761279No
244513411341.037.7137.7Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. Felix KratzJ Control Release200818582981No
244613401340.024.2324.2c-Myc target genes involved in cell growth, apoptosis, and metabolism. C V DangMol Cell Biol19999858526No
244713401340.027.3827.4The many faces of macrophage activation. David M MosserJ Leukoc Biol200312554797No
244813401340.00.00.0The critical incident technique. J C FlanaganPsychol Bull195413177800Yes
244913401340.043.243.2The amazing osteocyte. Lynda F BonewaldJ Bone Miner Res201121254230No
245013391339.047.8947.9Letter: Grading of angina pectoris. L CampeauCirculation1976947585Yes
245113391339.035.6135.6Fibronectin and its receptors. E RuoslahtiAnnu Rev Biochem19882972252No
245293731339.0380.3854.3Development and validation of a geriatric depression screening scale: a preliminary report. J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O LeirerJ Psychiatr Res19827183759Yes
245313391339.050.650.6Translating social ecological theory into guidelines for community health promotion. D StokolsAm J Health Promot199610159709No
245413391339.00.00.0A simple ultraviolet spectrophotometric method for the determination of protein. W J WaddellJ Lab Clin Med195613346201Yes
245513391339.012.6712.7Cellular resistance to infection. G B MackanessJ Exp Med196214467923Yes
245613391339.025.1625.2A modified procedure for lead staining of thin sections. G MillonigJ Biophys Biochem Cytol196114474176Yes
245726761338.093.4546.7Total energy intake: implications for epidemiologic analyses. W Willett, M J StampferAm J Epidemiol19863521261No
245813381338.047.2447.2Neuropeptide Y: complete amino acid sequence of the brain peptide. K TatemotoProc Natl Acad Sci U S A19826957876Yes
245913381338.029.2529.2Physiological concentrations of purines and pyrimidines. T W TrautMol Cell Biochem19947877593No
246013381338.041.9441.9Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Thomas HebererToxicol Lett200211988354Yes
246113371337.034.9735.0The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. K KuwajimaProteins19892695928No
246226731336.577.4438.7Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. A Dahlstroem, K FuxeActa Physiol Scand Suppl196414229500Yes
246313361336.028.528.5The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. G B MorinCell19892805070Yes
246426721336.059.7529.9A comparison of bayesian methods for haplotype reconstruction from population genotype data. Matthew Stephens, Peter DonnellyAm J Hum Genet200314574645Yes
246513361336.023.0423.0Protein modification by SUMO. Erica S JohnsonAnnu Rev Biochem200415189146No
246613361336.029.3529.4Transcriptional control of adipocyte formation. Stephen R FarmerCell Metab200617011499No
246713361336.038.238.2Cytokinesis-block micronucleus cytome assay. Michael FenechNat Protoc200717546000Yes
246813341334.028.6728.7Codon usage and tRNA content in unicellular and multicellular organisms. T IkemuraMol Biol Evol19853916708No
246913341334.029.6329.6Physiological and molecular basis of thyroid hormone action. P M YenPhysiol Rev200111427693No
247026681334.054.2827.1Regulated portals of entry into the cell. Sean D Conner, Sandra L SchmidNature200312621426No
247126681334.087.2443.6Origins and evolution of antibiotic resistance. Julian Davies, Dorothy DaviesMicrobiol Mol Biol Rev201020805405No
247226671333.574.8237.4Further improvements in the plaque technique for detecting single antibody-forming cells. A J Cunningham, A SzenbergImmunology19685653817Yes
247313331333.025.5825.6microRNAs: tiny regulators with great potential. V AmbrosCell200111779458No
247413331333.035.8335.8Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. E B HunzikerOsteoarthritis Cartilage200212056848No
247513321332.020.7220.7A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. A M OlovnikovJ Theor Biol19734754905Yes
247613301330.034.6434.6The aryl hydrocarbon receptor complex. O HankinsonAnnu Rev Pharmacol Toxicol19957598497No
247713301330.039.3439.3Circuitry and functional aspects of the insular lobe in primates including humans. J R AugustineBrain Res Brain Res Rev19968957561No
247813301330.041.9241.9Electrocatalyst approaches and challenges for automotive fuel cells. Mark K DebeNature201222678278Yes
247953151328.8130.6932.7Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. D W Cleveland, S G Fischer, M W Kirschner, U K LaemmliJ Biol Chem1977320200Yes
248026571328.582.6141.3CTFFIND4: Fast and accurate defocus estimation from electron micrographs. Alexis Rohou, Nikolaus GrigorieffJ Struct Biol201526278980Yes
248139821327.399.6533.2LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. A C Wallace, R A Laskowski, J M ThorntonProtein Eng19957630882Yes
248213271327.033.6933.7Thioredoxin and glutaredoxin systems. A HolmgrenJ Biol Chem19892668278No
248326541327.060.3930.2Integrins and signal transduction pathways: the road taken. E A Clark, J S BruggeScience19957716514No
248466301326.0181.9436.4Transection of the oesophagus for bleeding oesophageal varices. R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R WilliamsBr J Surg19734541913Yes
248513261326.025.5825.6Mechanisms of caspase activation and inhibition during apoptosis. Yigong ShiMol Cell200211931755No
248613261326.032.8632.9N-heterocyclic carbenes: a new concept in organometallic catalysis. Wolfgang A HerrmannAngew Chem Int Ed Engl200219750753Yes
248726511325.567.1833.6Therapeutic potential of resveratrol: the in vivo evidence. Joseph A Baur, David A SinclairNat Rev Drug Discov200616732220No
248826501325.072.4836.2A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. B G Durie, S E SalmonCancer19751182674Yes
248926501325.054.4327.2Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. P J Southern, P BergJ Mol Appl Genet19826286831Yes
249013251325.031.7531.8Apoptosis in cancer therapy: crossing the threshold. D E FisherCell19948069905No
249113251325.029.9329.9Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. W D SniderCell19948205613No
249239751325.096.9232.3Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. Y Zhang, M Brady, S SmithIEEE Trans Med Imaging200111293691Yes
249339731324.3209.4569.8Shedding light on the cell biology of extracellular vesicles. Guillaume van Niel, Gisela D'Angelo, Graça RaposoNat Rev Mol Cell Biol201829339798No
249413241324.023.0823.1Regulatory T cells: key controllers of immunologic self-tolerance. S SakaguchiCell200010850488No
249513241324.023.423.4SUMO: a history of modification. Ronald T HayMol Cell200515808504No
249613241324.033.9934.0Microbial influences in inflammatory bowel diseases. R Balfour SartorGastroenterology200818242222No
249713231323.050.9350.9Free-radical mechanisms in tissue injury. T F SlaterBiochem J19846383353No
249813231323.063.4363.4The clinical application of the biopsychosocial model. G L EngelAm J Psychiatry19807369396Yes
249913231323.028.0828.1The enzymes, regulation, and genetics of bile acid synthesis. David W RussellAnnu Rev Biochem200312543708No
250013231323.031.4231.4Recent advances in neuroblastoma. John M MarisN Engl J Med201020558371No
250113221322.024.6124.6Antigen-specific interaction between T and B cells. A LanzavecchiaNature19853157869Yes
250213221322.00.00.0On the psychophysical law. S S StevensPsychol Rev195713441853Yes
250339651321.7102.3734.1Cognitive and emotional influences in anterior cingulate cortex. G Bush, P Luu, M I PosnerTrends Cogn Sci200010827444Yes
250452841321.0116.8829.2Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J ThunN Engl J Med200312711737Yes
250539621320.797.3532.4The p53 tumour suppressor gene. A J Levine, J Momand, C A FinlayNature19912046748No
250639621320.790.330.1Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Witold Filipowicz, Suvendra N Bhattacharyya, Nahum SonenbergNat Rev Genet200818197166No
250726411320.555.4827.7Liver regeneration. G K Michalopoulos, M C DeFrancesScience19979082986No
250826411320.564.2132.1Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Uwe-Karsten Hanisch, Helmut KettenmannNat Neurosci200717965659No
250913201320.029.0629.1Measuring information transfer T SchreiberPhys Rev Lett200010991308Yes
251039581319.3106.8635.6Nitric oxide and peroxynitrite in health and disease. Pál Pacher, Joseph S Beckman, Lucas LiaudetPhysiol Rev200717237348No
251113191319.037.6837.7Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. W W DouglasBr J Pharmacol19684882190No
251213191319.065.2265.2Displaced proximal humeral fractures. I. Classification and evaluation. C S NeerJ Bone Joint Surg Am19705455339Yes
251313191319.023.0423.0Clonal selection and learning in the antibody system. K RajewskyNature19968657279No
251426381319.090.6645.3Functional interactions between the gut microbiota and host metabolism. Valentina Tremaroli, Fredrik BäckhedNature201222972297No
251526371318.596.7248.4Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. E Engvall, P PerlmannJ Immunol19724113792Yes
251626371318.548.5924.3Immunization of dissociated spleen cell cultures from normal mice. R I Mishell, R W DuttonJ Exp Med19676034749Yes
251713181318.048.148.1The life and times of the Enterococcus. B E MurrayClin Microbiol Rev19902404568No
251839541318.083.9628.0A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. R Medzhitov, P Preston-Hurlburt, C A JanewayNature19979237759Yes
251913181318.035.3735.4Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Arnold I CaplanJ Cell Physiol200717620285No
252013171317.042.6542.6An application of prefrontal cortex function theory to cognitive aging. R L WestPsychol Bull19968831298No
252113161316.036.9637.0The matrix-degrading metalloproteinases. L M MatrisianBioessays19921445287No
252213161316.039.0839.1Classification of chronic viral hepatitis: a need for reassessment. P J ScheuerJ Hepatol19911808228No
252313161316.017.0617.1Disconnexion syndromes in animals and man. I. N GeschwindBrain19655318481No
252413161316.033.333.3Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. R M SapolskyArch Gen Psychiatry200011015810No
252513161316.00.00.0A quantitative immunochemical measure of the primary interaction between I BSA and antibody. R S FarrJ Infect Dis195813611294Yes
252613161316.051.2751.3What is self-rated health and why does it predict mortality? Towards a unified conceptual model. Marja JylhäSoc Sci Med200919520474Yes
252713151315.034.6334.6Phylogenies from molecular sequences: inference and reliability. J FelsensteinAnnu Rev Genet19883071258No
252813151315.045.1145.1Carnitine--metabolism and functions. J BremerPhysiol Rev19836361812No
252913151315.028.5228.5Mechanisms of foxp3+ T regulatory cell-mediated suppression. Ethan M ShevachImmunity200919464986No
253026281314.0100.6250.3Malondialdehyde determination as index of lipid peroxidation. H H Draper, M HadleyMethods Enzymol19902233309Yes
253126281314.041.4520.7Functions of lysosomes. C De Duve, R WattiauxAnnu Rev Physiol19665322983No
253213141314.027.6627.7Double identity for proteins of the Bcl-2 family. J C ReedNature19979194558No
253313141314.028.0628.1Prediction of protein cellular attributes using pseudo-amino acid composition. K C ChouProteins200111288174Yes
253413141314.058.6658.7Machine Learning in Medicine. Rahul C DeoCirculation201526572668No
253526261313.048.8724.4New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. R D Gietz, A SuginoGene19883073106Yes
253626261313.058.2129.1Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Jane E Visvader, Geoffrey J LindemanNat Rev Cancer200818784658No
253726251312.546.3823.2Rab proteins as membrane organizers. M Zerial, H McBrideNat Rev Mol Cell Biol200111252952No
253852491312.2132.0833.0Universal sample preparation method for proteome analysis. Jacek R Wiśniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias MannNat Methods200919377485Yes
253913121312.026.9827.0Solving structures of protein complexes by molecular replacement with Phaser. Airlie J McCoyActa Crystallogr D Biol Crystallogr200717164524Yes
254013121312.037.6337.6BEDTools: The Swiss-Army Tool for Genome Feature Analysis. Aaron R QuinlanCurr Protoc Bioinformatics201425199790Yes
254152441311.0123.8131.0Improved prediction of signal peptides: SignalP 3.0. Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren BrunakJ Mol Biol200415223320Yes
254213101310.032.8232.8Comparative physiology of salt and water stress. R. MunnsPlant Cell Environ200211841667Yes
254326201310.061.330.6Microenvironmental regulation of metastasis. Johanna A Joyce, Jeffrey W PollardNat Rev Cancer200919279573No
254413101310.00.00.0Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. P F ScholanderJ Biol Chem194720281644Yes
254513101310.0118.66118.7Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Jonas F LudvigssonActa Paediatr202032202343Yes
254626191309.559.3329.7Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. E Y Chen, P H SeeburgDNA19853996185Yes
254713091309.033.8833.9Supported membranes: scientific and practical applications. E SackmannScience19968539599No
254813091309.032.5532.5Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. G L SemenzaOncogene201019946328No
254939251308.3139.5646.5A new method for off-line removal of ocular artifact. G Gratton, M G Coles, E DonchinElectroencephalogr Clin Neurophysiol19836187540Yes
255026161308.0117.0658.5Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. J M Tanner, R H WhitehouseArch Dis Child1976952550Yes
255126161308.058.0629.0ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. Matthew D Wilkerson, D Neil HayesBioinformatics201020427518Yes
255226161308.071.3535.7Tumor metastasis: molecular insights and evolving paradigms. Scott Valastyan, Robert A WeinbergCell201122000009No
255313071307.029.9229.9Oxidative stress in neurodegeneration: cause or consequence? Julie K AndersenNat Med200415298006No
255413071307.027.5227.5Human natural killer cells. Michael A CaligiuriBlood200818650461No
255539201306.793.2431.1Functional porous coordination polymers. Susumu Kitagawa, Ryo Kitaura, Shin-ichiro NoroAngew Chem Int Ed Engl200415114565Yes
255613061306.054.254.2Error in medicine. L L LeapeJAMA19947503827Yes
255713061306.023.6623.7CD95's deadly mission in the immune system. P H KrammerNature200011048730No
255813061306.00.00.0The anterior approach for removal of ruptured cervical disks. R B ClowardJ Neurosurg195813599052Yes
255913051305.069.8869.9Psychosocial resilience and protective mechanisms. Michael RutterAm J Orthopsychiatry19873303954No
256013051305.039.039.0Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Thomas GrobnerNephrol Dial Transplant200616431890Yes
256113041304.038.0738.1Qinghaosu (artemisinin): an antimalarial drug from China. D L KlaymanScience19853887571No
256226081304.040.2820.1The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. J Shine, L DalgarnoProc Natl Acad Sci U S A19744598299Yes
256313041304.035.2835.3Polycystic ovary syndrome. David A EhrmannN Engl J Med200515788499No
256413041304.044.2144.2AmpC beta-lactamases. George A JacobyClin Microbiol Rev200919136439No
256565181303.6250.8950.2Fsl. Mark Jenkinson, Christian F Beckmann, Timothy E J Behrens, Mark W Woolrich, Stephen M SmithNeuroimage201221979382No
256626071303.5106.0253.0A typology of reviews: an analysis of 14 review types and associated methodologies. Maria J Grant, Andrew BoothHealth Info Libr J200919490148No
256726071303.563.3331.7Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Subhra K Biswas, Alberto MantovaniNat Immunol201020856220No
256813031303.029.5429.5Metastatic bone disease: clinical features, pathophysiology and treatment strategies. R E ColemanCancer Treat Rev200111417967No
256913031303.030.9430.9Non-Smad pathways in TGF-beta signaling. Ying E ZhangCell Res200919114990No
257026051302.556.1728.1Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. M Zuker, P StieglerNucleic Acids Res19816163133Yes
257139071302.3146.6148.9Complex heatmaps reveal patterns and correlations in multidimensional genomic data. Zuguang Gu, Roland Eils, Matthias SchlesnerBioinformatics201627207943Yes
257213021302.031.2231.2Receptors for epidermal growth factor and other polypeptide mitogens. G CarpenterAnnu Rev Biochem19873039909No
257313021302.021.6521.6Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. W D HamiltonScience19676021675Yes
257426031301.543.6121.8Genetic transformation of Drosophila with transposable element vectors. G M Rubin, A C SpradlingScience19826289436Yes
257526031301.587.0243.5Social conditions as fundamental causes of disease. B G Link, J PhelanJ Health Soc Behav19957560851No
257613011301.044.5344.5The theoretical bases of indirect calorimetry: a review. E FerranniniMetabolism19883278194No
257739031301.080.2926.8Calcium signalling: dynamics, homeostasis and remodelling. Michael J Berridge, Martin D Bootman, H Llewelyn RoderickNat Rev Mol Cell Biol200312838335No
257813011301.034.234.2The sympathetic control of blood pressure. Patrice G GuyenetNat Rev Neurosci200616760914No
257926021301.095.047.5Role of the microbiota in immunity and inflammation. Yasmine Belkaid, Timothy W HandCell201424679531No
258026011300.582.6541.3Epidermal growth factor. G Carpenter, S CohenAnnu Rev Biochem1979382984No
258139001300.085.9728.7Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Axel Nimmerjahn, Frank Kirchhoff, Fritjof HelmchenScience200515831717Yes
258238981299.390.5530.2Tissue cells feel and respond to the stiffness of their substrate. Dennis E Discher, Paul Janmey, Yu-Li WangScience200516293750No
258312981298.011.6511.7Metabolic stability and epigenesis in randomly constructed genetic nets. S A KauffmanJ Theor Biol19695803332Yes
258425961298.066.8833.4Apoptosis, oncosis, and necrosis. An overview of cell death. G Majno, I JorisAm J Pathol19957856735No
258512981298.057.3157.31,500 scientists lift the lid on reproducibility. Monya BakerNature201627225100No
258625961298.0190.795.3ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R. Emmanuel Paradis, Klaus SchliepBioinformatics201930016406Yes
258712971297.042.342.3Optimal foraging, the marginal value theorem. E L CharnovTheor Popul Biol19761273796Yes
258812971297.034.4934.5Sarcopenia: origins and clinical relevance. I H RosenbergJ Nutr19979164280No
258977771296.2197.0232.8Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat RoblesBioinformatics200516081474Yes
259012961296.028.4728.5Long-term potentiation and memory. M A LynchPhysiol Rev200414715912No
259112961296.029.8929.9The path to ubiquitous and low-cost organic electronic appliances on plastic. Stephen R ForrestNature200415118718Yes
259212951295.043.643.6Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. J H LuftAnat Rec19714108333Yes
259312951295.060.160.1Oxidative stress: a concept in redox biology and medicine. Helmut SiesRedox Biol201525588755No
259425891294.555.7427.9Mitochondrial control of cell death. G Kroemer, J C ReedNat Med200010802706No
259538831294.399.4733.2Atomic force microscope. G Binnig, C F Quate, C GerberPhys Rev Lett198610033323Yes
259612941294.00.00.0On the local reactions of the arterial wall to changes of internal pressure. W M BaylissJ Physiol190216992618Yes
259712941294.00.00.0Limitations of the application of fourfold table analysis to hospital data. J BerksonBiometrics194621001024Yes
259864671293.4158.8431.8Enzymatic determination of total serum cholesterol. C C Allain, L S Poon, C S Chan, W Richmond, P C FuClin Chem19744818200Yes
259925861293.061.5230.8Multipoint quantitative-trait linkage analysis in general pedigrees. L Almasy, J BlangeroAm J Hum Genet19989545414Yes
260012931293.030.1630.2Pathways of oxidative damage. James A ImlayAnnu Rev Microbiol200314527285No
260151711292.8103.6625.9Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. D D Sarbassov, David A Guertin, Siraj M Ali, David M SabatiniScience200515718470Yes
260225851292.537.7718.9Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. J E Sulston, H R HorvitzDev Biol1977838129Yes
260312921292.031.7431.7Surrogate endpoints in clinical trials: definition and operational criteria. R L PrenticeStat Med19892727467Yes
260425841292.082.7241.4Tumor-associated macrophages: from mechanisms to therapy. Roy Noy, Jeffrey W PollardImmunity201425035953No
260525831291.558.9129.5Cell cycle, CDKs and cancer: a changing paradigm. Marcos Malumbres, Mariano BarbacidNat Rev Cancer200919238148No
260625801290.075.0737.5Prediction of the secondary structure of proteins from their amino acid sequence. P Y Chou, G D FasmanAdv Enzymol Relat Areas Mol Biol1978364941No
260712901290.029.5229.5Oxyradicals and DNA damage. L J MarnettCarcinogenesis200010688856No
260812901290.037.9738.0Endometriosis. Serdar E BulunN Engl J Med200919144942No
260925791289.561.2730.6Production of single-stranded plasmid DNA. J Vieira, J MessingMethods Enzymol19873323803Yes
261012891289.029.7329.7Tumour necrosis factor and cancer. Frances BalkwillNat Rev Cancer200919343034No
261138661288.7101.0633.7Bacterial biofilms: from the natural environment to infectious diseases. Luanne Hall-Stoodley, J William Costerton, Paul StoodleyNat Rev Microbiol200415040259No
261225771288.571.1135.6What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? K C Berridge, T E RobinsonBrain Res Brain Res Rev19989858756No
261312881288.030.4230.4Lymphokine production by human T cells in disease states. S RomagnaniAnnu Rev Immunol19948011282No
261464401288.0121.624.3Crystal structure of the nucleosome core particle at 2.8 A resolution. K Luger, A W Mäder, R K Richmond, D F Sargent, T J RichmondNature19979305837Yes
261551501287.5224.0756.0Progressive statistics for studies in sports medicine and exercise science. William G Hopkins, Stephen W Marshall, Alan M Batterham, Juri HaninMed Sci Sports Exerc200919092709No
261612871287.034.4234.4Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. A BöyumScand J Clin Lab Invest Suppl19684179066Yes
261712871287.039.3439.3Chronic disease management: what will it take to improve care for chronic illness? E H WagnerEff Clin Pract199810345255No
261812871287.033.133.1Psychological and neural mechanisms of the affective dimension of pain. D D PriceScience200010846154No
261912871287.027.227.2The stem-cell niche as an entity of action. David T ScaddenNature200616810242No
262038601286.790.8630.3Evolution and functions of long noncoding RNAs. Chris P Ponting, Peter L Oliver, Wolf ReikCell200919239885No
262125731286.587.6443.8Regulatory sequences involved in the promotion and termination of RNA transcription. M Rosenberg, D CourtAnnu Rev Genet197994251No
262212861286.040.4340.4Electrophoretic separation of plasma lipoproteins in agarose gel. R P NobleJ Lipid Res19684176473Yes
262312861286.059.3259.3Cardiovascular and renal actions of dopamine: potential clinical applications. L I GoldbergPharmacol Rev19724554480No
262412861286.035.1635.2The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. R G GerrityAm J Pathol19817234961Yes
262512861286.029.0829.1Refined structure of the nicotinic acetylcholine receptor at 4A resolution. Nigel UnwinJ Mol Biol200515701510Yes
262625711285.581.9241.0Oxidative mechanisms in the toxicity of metal ions. S J Stohs, D BagchiFree Radic Biol Med19957744317No
262725701285.065.3132.7Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. J A Ledbetter, L A HerzenbergImmunol Rev1979398327No
262812851285.029.0429.0Chemistry and biology of the immunophilins and their immunosuppressive ligands. S L SchreiberScience19911702904No
262912851285.038.938.9Diversity and ubiquity of K channels. B RudyNeuroscience19882457185No
263012851285.030.6730.7Papillomavirus infections--a major cause of human cancers. H zur HausenBiochim Biophys Acta19968876633No
263112851285.040.4540.5Thermal properties of graphene and nanostructured carbon materials. Alexander A BalandinNat Mater201121778997Yes
263225691284.556.5728.3Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. S W Hell, J WichmannOpt Lett199419844443Yes
263312841284.032.6832.7Pain and emotion interactions in subregions of the cingulate gyrus. Brent A VogtNat Rev Neurosci200515995724No
263425671283.5158.779.3Facial nerve grading system. J W House, D E BrackmannOtolaryngol Head Neck Surg19853921901Yes
263525671283.563.7231.9Interneurons of the hippocampus. T F Freund, G BuzsákiHippocampus19968915675No
263625671283.561.4830.7C-reactive protein: a critical update. Mark B Pepys, Gideon M HirschfieldJ Clin Invest200312813013No
263725641282.0129.1364.6A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. M Roland, R MorrisSpine (Phila Pa 1976)19836222486Yes
263825641282.046.7123.4Live or let die: the cell's response to p53. Karen H Vousden, Xin LuNat Rev Cancer200212154352No
2639141021282.0380.7534.6The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J RoccellaJAMA200312748199No
264025641282.00.00.0Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. H A Edmondson, P E SteinerCancer195413160935Yes
264112821282.031.731.7Overview of general physiologic features and functions of vitamin D. Hector F DeLucaAm J Clin Nutr200415585789No
264212811281.039.4539.5Somatostatin. S ReichlinN Engl J Med19836139753No
264312811281.028.3528.4Liver fibrosis -- from bench to bedside. Scott L FriedmanJ Hepatol200312591185No
264412811281.023.9624.0Mobile elements: drivers of genome evolution. Haig H KazazianScience200415016989No
264512811281.026.8926.9Neuroligins and neurexins link synaptic function to cognitive disease. Thomas C SüdhofNature200818923512No
264625611280.566.1733.1Establishment and characterization of a human histiocytic lymphoma cell line (U-937). C Sundström, K NilssonInt J Cancer1976178611Yes
264725611280.546.0223.0DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Christopher J Bakkenist, Michael B KastanNature200312556884Yes
264825611280.555.0227.5The pathophysiology of mitochondrial cell death. Douglas R Green, Guido KroemerScience200415286356No
264912801280.041.1841.2How stigma interferes with mental health care. Patrick CorriganAm Psychol200415491256Yes
265038381279.386.7628.9Photodynamic therapy for cancer. Dennis E J G J Dolmans, Dai Fukumura, Rakesh K JainNat Rev Cancer200312724736No
265138381279.3127.0942.4Rehospitalizations among patients in the Medicare fee-for-service program. Stephen F Jencks, Mark V Williams, Eric A ColemanN Engl J Med200919339721Yes
265212791279.046.6746.7Substance P. B PernowPharmacol Rev19836196797No
265312791279.028.4928.5Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. T A SpringerAnnu Rev Physiol19957778885No
265412791279.00.00.0Agammaglobulinemia. O C BrutonPediatrics195214929630Yes
265512791279.054.9254.9Rhythms for Cognition: Communication through Coherence. Pascal FriesNeuron201526447583No
265689501278.6253.5136.2Cancer statistics, 2008. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J ThunCA Cancer J Clin200818287387Yes
265725571278.552.5826.3The molecular biology of axon guidance. M Tessier-Lavigne, C S GoodmanScience19968895455No
265812781278.040.9741.0Bee and wasp venoms. E HabermannScience19724113805No
265912781278.079.9479.9A comparison of canal preparations in straight and curved root canals. S W SchneiderOral Surg Oral Med Oral Pathol19715284110Yes
266012781278.043.0543.0Density matrix formulation for quantum renormalization groups. S R WhitePhys Rev Lett199210046608Yes
266125551277.562.7831.4The free radical theory of aging matures. K B Beckman, B N AmesPhysiol Rev19989562038No
266225551277.50.00.0Construct validity in psychological tests. L J Cronbach, P E MeehlPsychol Bull195513245896Yes
266312771277.032.0132.0The mitochondrial electron transport and oxidative phosphorylation system. Y HatefiAnnu Rev Biochem19852862839No
266425541277.023.6211.8Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Altman, G D DasJ Comp Neurol19655861717Yes
266512771277.044.7444.7Plasma perspective on strong field multiphoton ionization. P B CorkumPhys Rev Lett199310054556Yes
266612771277.034.5434.5Neural simulation of action: a unifying mechanism for motor cognition. M JeannerodNeuroimage200111373140No
266712771277.022.4622.5The molecular motor toolbox for intracellular transport. Ronald D ValeCell200312600311No
266812771277.041.3941.4The epidemiology of adult obstructive sleep apnea. Naresh M PunjabiProc Am Thorac Soc200818250205No
266925541277.054.6727.3The canonical Notch signaling pathway: unfolding the activation mechanism. Raphael Kopan, Maria Xenia G IlaganCell200919379690No
267012771277.055.155.1Transcriptional architecture of the mammalian circadian clock. Joseph S TakahashiNat Rev Genet201727990019No
267112761276.027.1827.2Sustainable hydrogen production. John A TurnerScience200415310892Yes
267212761276.026.926.9Recognition and processing of ubiquitin-protein conjugates by the proteasome. Daniel FinleyAnnu Rev Biochem200919489727No
267312751275.055.8555.9Biomaterial-centered infection: microbial adhesion versus tissue integration. A G GristinaScience19873629258Yes
267412751275.060.8360.8New norms of upper limb fat and muscle areas for assessment of nutritional status. A R FrisanchoAm J Clin Nutr19816975564Yes
267512751275.00.00.0Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. H M KalckarJ Biol Chem194720285041Yes
267676481274.7191.9132.0An obesity-associated gut microbiome with increased capacity for energy harvest. Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I GordonNature200617183312Yes
267712741274.025.5725.6Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. R H SchwartzCell19921335362No
267812741274.020.9120.9Antigen receptor tail clue. M RethNature19892927501Yes
267925471273.567.1933.6Integrins in cancer: biological implications and therapeutic opportunities. Jay S Desgrosellier, David A ChereshNat Rev Cancer201020029421No
268025461273.063.1431.6Neuronal plasticity: increasing the gain in pain. C J Woolf, M W SalterScience200010846153No
268112731273.033.8433.8The biochemistry and medical significance of the flavonoids. Bent H HavsteenPharmacol Ther200212453566No
268225451272.567.4633.7Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Ajay Kumar Gupta, Mona GuptaBiomaterials200515626447No
268338171272.3135.9145.3Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Marina Colombo, Graça Raposo, Clotilde ThéryAnnu Rev Cell Dev Biol201425288114No
268412721272.029.2529.2The prefrontal cortex and cognitive control. E K MillerNat Rev Neurosci200011252769No
268512721272.032.1332.1Plasmonics: merging photonics and electronics at nanoscale dimensions. Ekmel OzbayScience200616410515Yes
268612721272.031.4231.4Hydrogen sulphide and its therapeutic potential. Csaba SzabóNat Rev Drug Discov200717948022No
268712721272.00.00.0The antidiuretic hormone and the factors which determine its release. E B VerneyProc R Soc Lond B Biol Sci194718918876Yes
268812721272.038.5338.5Persister cells. Kim LewisAnnu Rev Microbiol201020528688No
268925431271.548.8324.4Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. M Fried, D M CrothersNucleic Acids Res19816275366Yes
269025431271.558.7229.4Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Kornelia Polyak, Robert A WeinbergNat Rev Cancer200919262571No
269125421271.056.5928.3The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. P M Sharp, W H LiNucleic Acids Res19873547335Yes
269225421271.050.6425.3A rapid, sensitive, and specific method for the determination of protein in dilute solution. W Schaffner, C WeissmannAnal Biochem19734128882Yes
269325421271.059.0929.5Quorum sensing in bacteria. M B Miller, B L BasslerAnnu Rev Microbiol200111544353No
269425421271.073.3136.7Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. Aluísio J D Barros, Vânia N HirakataBMC Med Res Methodol200314567763Yes
269550821270.5112.3828.1A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry SharplessAngew Chem Int Ed Engl200212203546Yes
269625401270.061.4430.7Drug delivery systems: entering the mainstream. Theresa M Allen, Pieter R CullisScience200415031496Yes
269712701270.042.2942.3Phenylpropanoid biosynthesis. Thomas VogtMol Plant201020035037No
269812701270.0117.54117.5COVID-19 and African Americans. Clyde W YancyJAMA202032293639Yes
269925381269.076.1138.1An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Sun Ho Kim, Jin Mo ChungPain19921333581Yes
270025381269.057.1628.6Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. D A Brown, J K RoseCell19921531449Yes
270112691269.034.7834.8Tumor angiogenesis. J FolkmanAdv Cancer Res19852581424No
270212691269.034.2734.3How brains beware: neural mechanisms of emotional attention. Patrik VuilleumierTrends Cogn Sci200516289871Yes
270325371268.586.1543.1Surgical risk as related to time of intervention in the repair of intracranial aneurysms. W E Hunt, R M HessJ Neurosurg19685635959Yes
270412681268.029.9630.0Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Hiroshi TakayanagiNat Rev Immunol200717380158No
270512681268.036.7936.8Species concepts and species delimitation. Kevin De QueirozSyst Biol200718027281Yes
270638001266.790.4930.2Dystrophin: the protein product of the Duchenne muscular dystrophy locus. E P Hoffman, R H Brown, L M KunkelCell19873319190Yes
270738001266.7127.5942.5Job burnout. C Maslach, W B Schaufeli, M P LeiterAnnu Rev Psychol200111148311Yes
270825331266.567.8533.9Chlorophyll fluorescence--a practical guide. K Maxwell, G N JohnsonJ Exp Bot200010938857No
270912661266.030.4930.5Short-term synaptic plasticity. R S ZuckerAnnu Rev Neurosci19892648947No
271012661266.043.9844.0PaDEL-descriptor: an open source software to calculate molecular descriptors and fingerprints. Chun Wei YapJ Comput Chem201121425294Yes
271125321266.076.9238.5Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Christine Vogel, Edward M MarcotteNat Rev Genet201222411467No
271225321266.080.0140.0Molecular and cellular insights into T cell exhaustion. E John Wherry, Makoto KurachiNat Rev Immunol201526205583No
271337971265.7169.3456.4In search of how people change. Applications to addictive behaviors. J O Prochaska, C C DiClemente, J C NorcrossAm Psychol19921329589Yes
271450621265.5184.8746.2The chemistry and applications of metal-organic frameworks. Hiroyasu Furukawa, Kyle E Cordova, Michael O'Keeffe, Omar M YaghiScience201323990564Yes
271537961265.3103.0734.4Molecular characterization of a peripheral receptor for cannabinoids. S Munro, K L Thomas, M Abu-ShaarNature19937689702Yes
271612651265.025.825.8Endocytosis and molecular sorting. I MellmanAnnu Rev Cell Dev Biol19968970738No
271712651265.036.5336.5Deconvoluting the context-dependent role for autophagy in cancer. Eileen WhiteNat Rev Cancer201222534666No
271825291264.59.584.8Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. G J Todaro, H GreenJ Cell Biol196313985244Yes
271912641264.024.7924.8Structure and function of intercellular junctions. L A StaehelinInt Rev Cytol19744611943No
272012641264.026.0226.0Signal transduction via the MAP kinases: proceed at your own RSK. J BlenisProc Natl Acad Sci U S A19938392180No
272112641264.021.5921.6Cancer susceptibility and the functions of BRCA1 and BRCA2. Ashok R VenkitaramanCell200211832208No
272212631263.032.1632.2Rapid evolution of a protein in vitro by DNA shuffling. W P StemmerNature19948047147Yes
272312631263.031.5431.5Apoptosis. J J CohenImmunol Today19938466628No
272412631263.034.9434.9Regulation of glutathione synthesis. Shelly C LuMol Aspects Med200918601945No
272525261263.080.5940.3DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI. Yan Chao-Gan, Zang Yu-FengFront Syst Neurosci201020577591Yes
272612621262.036.2436.2A Wilcoxon-type test for trend. J CuzickStat Med19853992076Yes
272725231261.549.0124.5CpG islands in vertebrate genomes. M Gardiner-Garden, M FrommerJ Mol Biol19873656447Yes
272825231261.544.4922.2The DNA damage response: putting checkpoints in perspective. B B Zhou, S J ElledgeNature200011100718No
272912611261.014.1314.1A restriction point for control of normal animal cell proliferation. A B PardeeProc Natl Acad Sci U S A19744524638Yes
273012611261.031.3131.3Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. J DeisenhoferBiochemistry19817236608Yes
273112611261.025.825.8SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. S V EvansJ Mol Graph19938347566Yes
273225221261.062.0331.0Pharmacology and functions of metabotropic glutamate receptors. P J Conn, J P PinAnnu Rev Pharmacol Toxicol19979131252No
273312611261.025.2725.3Searching for genetic determinants in the new millennium. N J RischNature200010866211No
273425221261.051.5325.8Tumorigenesis and the angiogenic switch. Gabriele Bergers, Laura E BenjaminNat Rev Cancer200312778130No
273512601260.033.7533.8Signaling through phosphatidylcholine breakdown. J H ExtonJ Biol Chem19902104616No
273625201260.066.9133.5Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. J L Weber, P E MayAm J Hum Genet19892916582Yes
273712601260.031.5831.6The effective period of preventive antibiotic action in experimental incisions and dermal lesions. J F BurkeSurgery196116722001Yes
273825181259.068.8334.4Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Taro Kawai, Shizuo AkiraImmunity201121616434No
273937761258.790.0330.0Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Christopher R Genovese, Nicole A Lazar, Thomas NicholsNeuroimage200211906227Yes
274025171258.556.2228.1Can the pharmaceutical industry reduce attrition rates? Ismail Kola, John LandisNat Rev Drug Discov200415286737No
274125171258.594.7947.4Liposomal drug delivery systems: from concept to clinical applications. Theresa M Allen, Pieter R CullisAdv Drug Deliv Rev201323036225No
274212581258.027.827.8Life, death, and the pursuit of apoptosis. E WhiteGenes Dev19968557188No
274312581258.035.5935.6Plant productivity and environment. J S BoyerScience198217808529Yes
274412581258.00.00.0A simple objective technique for measuring flexibility in thinking. E A BergJ Gen Psychol194818889466Yes
274512581258.040.1940.2Tumor delivery of macromolecular drugs based on the EPR effect. Vladimir TorchilinAdv Drug Deliv Rev201120304019No
274612581258.072.6272.6DLS and zeta potential - What they are and what they are not? Sourav BhattacharjeeJ Control Release201627297779No
274712571257.035.935.9Strategy and tactics in protein chemistry. B S HartleyBiochem J19704923920No
274825141257.077.6238.8Modeling and comparison of dissolution profiles. P Costa, J M Sousa LoboEur J Pharm Sci200111297896No
274950271256.8144.6336.2Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Weidner, J P Semple, W R Welch, J FolkmanN Engl J Med19911701519Yes
275025131256.5152.5276.3A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. E S Grood, W J SuntayJ Biomech Eng19836865355Yes
275112561256.026.2126.2Nucleic acid junctions and lattices. N C SeemanJ Theor Biol19826188926Yes
275212561256.036.0336.0Peptide antibiotics and their role in innate immunity. H G BomanAnnu Rev Immunol19957612236No
275312561256.029.9229.9Somatostatin and its receptor family. Y C PatelFront Neuroendocrinol199910433861No
275412561256.029.5329.5Reactive oxygen radicals in signaling and damage in the ischemic brain. P H ChanJ Cereb Blood Flow Metab200111149664No
275512561256.062.262.2Biological roles of glycans. Ajit VarkiGlycobiology201727558841No
275612551255.053.8553.9Environmentally induced oxidative stress in aquatic animals. Volodymyr I LushchakAquat Toxicol201121074869No
275737641254.7111.0337.0The functional anatomy of basal ganglia disorders. R L Albin, A B Young, J B PenneyTrends Neurosci19892479133No
275825091254.572.7536.4Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. J I Morgan, T CurranAnnu Rev Neurosci19911903243No
275925091254.550.9525.5ERBB receptors and cancer: the complexity of targeted inhibitors. Nancy E Hynes, Heidi A LaneNat Rev Cancer200515864276No
276012541254.034.2334.2Internal models for motor control and trajectory planning. M KawatoCurr Opin Neurobiol199910607637No
276125071253.547.0923.5The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. T Maehama, J E DixonJ Biol Chem19989593664Yes
276225051252.557.9229.0DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. S Tabor, C C RichardsonProc Natl Acad Sci U S A19873474623Yes
276312521252.042.0842.1Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. R LotanBiochim Biophys Acta19806989400No
276437561252.0112.0837.4Oxidants, antioxidants, and the degenerative diseases of aging. B N Ames, M K Shigenaga, T M HagenProc Natl Acad Sci U S A19938367443No
276512521252.024.7724.8STATs: signal transducers and activators of transcription. J N IhleCell19968608586No
276612521252.033.133.1Persister cells, dormancy and infectious disease. Kim LewisNat Rev Microbiol200717143318No
276712511251.034.7834.8Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. P VestergaardOsteoporos Int200717068657No
276825011250.5213.13106.6Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. R B Gustilo, J T AndersonJ Bone Joint Surg Am1976773941Yes
276912501250.027.1127.1S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. R DonatoInt J Biochem Cell Biol200111390274No
277012501250.026.7526.8Molecular physiology of low-voltage-activated t-type calcium channels. Edward Perez-ReyesPhysiol Rev200312506128No
277125001250.063.7431.9Hydrogels for tissue engineering: scaffold design variables and applications. Jeanie L Drury, David J MooneyBiomaterials200312922147No
277237471249.0136.9545.6Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. C J Caspersen, K E Powell, G M ChristensonPublic Health Rep19853920711Yes
277312491249.062.762.7Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. Anna Maria CarlssonPain19836602967Yes
277424981249.068.8734.4Nitric oxide synthases: roles, tolls, and controls. C Nathan, Q W XieCell19947522969No
277512491249.042.6342.6Inhibition and facilitation of nucleic acid amplification. I G WilsonAppl Environ Microbiol19979327537No
277612491249.026.026.0The roles of intracellular protein-degradation pathways in neurodegeneration. David C RubinszteinNature200617051204No
277737451248.3103.9734.7Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Günter Oberdörster, Eva Oberdörster, Jan OberdörsterEnviron Health Perspect200516002369No
2778137261247.8328.1829.8New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G GwytherJ Natl Cancer Inst200010655437No
277949911247.8104.7226.2Interleukin-10 and the interleukin-10 receptor. K W Moore, R de Waal Malefyt, R L Coffman, A O'GarraAnnu Rev Immunol200111244051No
278049901247.5116.0129.0Autophagy fights disease through cellular self-digestion. Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J KlionskyNature200818305538No
278112471247.082.6182.6The problem of rigor in qualitative research. M SandelowskiANS Adv Nurs Sci19863083765Yes
278212471247.057.4357.4A cognitive approach to panic. D M ClarkBehav Res Ther19863741311Yes
278324941247.048.6324.3Gene silencing in cancer in association with promoter hypermethylation. James G Herman, Stephen B BaylinN Engl J Med200314627790No
278424941247.062.8231.4Nanostructures in biodiagnostics. Nathaniel L Rosi, Chad A MirkinChem Rev200515826019No
278512471247.038.3238.3Understanding diagnostic tests 3: Receiver operating characteristic curves. Anthony K AkobengActa Paediatr200717376185No
278637411247.0295.4298.5Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles. Aldenor G Santos, Gisele O da Rocha, Jailson B de AndradeSci Rep201930626917Yes
278712461246.032.6732.7The lipocalin protein family: structure and function. D R FlowerBiochem J19968761444No
278812461246.024.4224.4Cytokines induce the development of functionally heterogeneous T helper cell subsets. A O'GarraImmunity19989529145No
278912461246.090.0690.1SARS-CoV-2 vaccines in development. Florian KrammerNature202032967006No
279012451245.041.8941.9How is the level of free arachidonic acid controlled in mammalian cells? R F IrvineBiochem J19826810878No
279112451245.034.634.6The effects of stressful life events on depression. R C KesslerAnnu Rev Psychol19979046559No
279212451245.028.2328.2Evaluating medication effects outside of clinical trials: new-user designs. Wayne A RayAm J Epidemiol200314585769Yes
279312451245.031.2831.3TNF-mediated inflammatory disease. J R BradleyJ Pathol200818161752No
279424891244.563.331.6Genetic dissection of complex traits. E S Lander, N J SchorkScience19948091226No
279512441244.023.4623.5Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. P RakicJ Comp Neurol19714101340Yes
279624881244.061.6630.8Molecular mechanisms of action of steroid/thyroid receptor superfamily members. M J Tsai, B W O'MalleyAnnu Rev Biochem19947979245No
279724881244.094.5347.3Cronbach's alpha. J M Bland, D G AltmanBMJ19979055718Yes
279812441244.030.8130.8Optimal experimental design for event-related fMRI. A M DaleHum Brain Mapp199910524601Yes
279974631243.8215.3635.9Free radicals and antioxidants in normal physiological functions and human disease. Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua TelserInt J Biochem Cell Biol200716978905No
280012431243.028.528.5Optical microcavities. Kerry J VahalaNature200312917698Yes
280112431243.00.00.0Intra-sexual selection in Drosophila. A J BatemanHeredity (Edinb)194818103134Yes
280224851242.590.2245.1The stunned myocardium: prolonged, postischemic ventricular dysfunction. E Braunwald, R A KlonerCirculation19826754130No
280324851242.565.632.8Epidemiology and outcomes of osteoporotic fractures. Steven R Cummings, L Joseph MeltonLancet200212049882No
280424831241.564.6732.3Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Barry J Everitt, Trevor W RobbinsNat Neurosci200516251991No
280512411241.030.2230.2Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. P KuzmicAnal Biochem19968660575Yes
280612411241.035.8735.9Invasive aspergillosis. D W DenningClin Infect Dis19989564455No
280724811240.561.1930.6Hydrogels for tissue engineering. K Y Lee, D J MooneyChem Rev200111710233No
280837211240.3116.3538.8MR diffusion tensor spectroscopy and imaging. P J Basser, J Mattiello, D LeBihanBiophys J19948130344Yes
280912401240.037.8137.8Calcium channel modulation by neurotransmitters, enzymes and drugs. H ReuterNature19836131381No
281012401240.035.8535.9Subcutaneous and visceral adipose tissue: structural and functional differences. M Mohsen IbrahimObes Rev201019656312No
281137181239.387.1429.0Global and societal implications of the diabetes epidemic. P Zimmet, K G Alberti, J ShawNature200111742409No
281261961239.2284.356.9BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs. Felipe A Simão, Robert M Waterhouse, Panagiotis Ioannidis, Evgenia V Kriventseva, Evgeny M ZdobnovBioinformatics201526059717Yes
281312391239.026.0226.0Antigen-presenting function of the macrophage. E R UnanueAnnu Rev Immunol19846242349No
281412391239.031.8131.8Drug delivery and targeting. R LangerNature19989579855No
281512391239.00.00.0A modification of receptor theory. R P StephensonBr J Pharmacol Chemother195613383117Yes
281624771238.579.5639.8The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. Julie D Henry, John R CrawfordBr J Clin Psychol200516004657Yes
281712381238.030.0830.1Primate anterior cingulate cortex: where motor control, drive and cognition interface. T PausNat Rev Neurosci200111389475No
281812381238.038.0238.0Risk and maintenance factors for eating pathology: a meta-analytic review. Eric SticePsychol Bull200212206196No
281912381238.026.4226.4Assortative mixing in networks. M E J NewmanPhys Rev Lett200212443515Yes
282012381238.030.0230.0Electrochemiluminescence (ECL). Mark M RichterChem Rev200415186186No
282112381238.038.7538.8Nanobodies: natural single-domain antibodies. Serge MuyldermansAnnu Rev Biochem201323495938No
282224751237.547.9824.0Proliferation, cell cycle and apoptosis in cancer. G I Evan, K H VousdenNature200111357141No
282324751237.553.1826.6Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Eugenia E Calle, Rudolf KaaksNat Rev Cancer200415286738No
282461871237.4248.249.6The Phyre2 web portal for protein modeling, prediction and analysis. Lawrence A Kelley, Stefans Mezulis, Christopher M Yates, Mark N Wass, Michael J E SternbergNat Protoc201525950237Yes
282586611237.3219.0531.3Integrative genomics viewer. James T Robinson, Helga Thorvaldsdóttir, Wendy Winckler, Mitchell Guttman, Eric S Lander, Gad Getz, Jill P MesirovNat Biotechnol201121221095Yes
282624741237.047.7423.9Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. C W Greider, E H BlackburnCell19853907856Yes
282712371237.047.7847.8Minority stress and mental health in gay men. I H MeyerJ Health Soc Behav19957738327Yes
282837111237.0141.1447.0Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis. Christopher K Prier, Danica A Rankic, David W C MacMillanChem Rev201323509883No
282924731236.553.4226.7The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. B N Ames, D T DubinJ Biol Chem196013793161Yes
283024731236.562.3731.2Epidemiology of Parkinson's disease. Lonneke M L de Lau, Monique M B BretelerLancet Neurol200616713924No
283112361236.00.00.0Sequential tests for the detection of linkage. N E MortonAm J Hum Genet195513258560Yes
283212361236.032.4332.4Thermo- and pH-responsive polymers in drug delivery. Dirk SchmaljohannAdv Drug Deliv Rev200617125884No
283324701235.0101.7150.9Reading senseless sentences: brain potentials reflect semantic incongruity. M Kutas, S A HillyardScience19807350657Yes
283412351235.035.1635.2Varieties of impulsivity. J L EvendenPsychopharmacology (Berl)199910550486No
283512351235.032.0132.0Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Earl S FordDiabetes Care200515983333No
283624691234.548.3724.2Checkpoints: controls that ensure the order of cell cycle events. L H Hartwell, T A WeinertScience19892683079No
283724691234.5103.5651.8Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Roel Nusse, Hans CleversCell201728575679No
283837031234.371.6223.9Exosomes: composition, biogenesis and function. Clotilde Théry, Laurence Zitvogel, Sebastian AmigorenaNat Rev Immunol200212154376No
283912341234.051.3851.4A cochlear frequency-position function for several species--29 years later. D D GreenwoodJ Acoust Soc Am19902373794Yes
284012341234.00.00.0The relation of the trail making test to organic brain damage. R M ReitanJ Consult Psychol195513263471Yes
284112341234.034.9234.9Targeting recovery: priorities of the spinal cord-injured population. Kim D AndersonJ Neurotrauma200415672628Yes
284212341234.046.5546.5Microtiter dish biofilm formation assay. George A O'TooleJ Vis Exp201121307833Yes
284386371233.9254.5236.4Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E MarshStroke19937678184Yes
284424671233.566.1433.1Meeting of minds: the medial frontal cortex and social cognition. David M Amodio, Chris D FrithNat Rev Neurosci200616552413No
284524671233.566.3233.2Increasing incidence of thyroid cancer in the United States, 1973-2002. Louise Davies, H Gilbert WelchJAMA200616684987Yes
284612331233.032.4532.5Low density lipoprotein oxidation and its pathobiological significance. D SteinbergJ Biol Chem19979261091No
284712331233.040.3440.3Function and information content of DNA methylation. Dirk SchübelerNature201525592537No
284812321232.027.3427.3Neurobiology of Pavlovian fear conditioning. S MarenAnnu Rev Neurosci200111520922No
284924631231.568.2434.1Ageing and Parkinson's disease: substantia nigra regional selectivity. J M Fearnley, A J LeesBrain19911933245Yes
285024631231.567.6833.8The cognitive control of emotion. Kevin N Ochsner, James J GrossTrends Cogn Sci200515866151No
285149261231.5130.3632.6Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S VasanStat Med200817569110Yes
285261571231.4192.7238.5Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. J S Beckman, T W Beckman, J Chen, P A Marshall, B A FreemanProc Natl Acad Sci U S A19902154753Yes
285336941231.3103.8534.6The Patient Health Questionnaire-2: validity of a two-item depression screener. Kurt Kroenke, Robert L Spitzer, Janet B W WilliamsMed Care200314583691Yes
285412311231.038.4838.5Antioxidants in human health and disease. B HalliwellAnnu Rev Nutr19968839918No
285512301230.026.5926.6Nuclear factor-kappaB: the enemy within. Bharat B AggarwalCancer Cell200415380510No
285624601230.055.3827.7Cellular processing of platinum anticancer drugs. Dong Wang, Stephen J LippardNat Rev Drug Discov200515789122No
285712301230.026.4226.4Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nicholas C DenkoNat Rev Cancer200819143055No
285812291229.021.7321.7Mutation selection and the natural history of cancer. J CairnsNature19751143315Yes
285912291229.044.1344.1Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. R M PostAm J Psychiatry19921353322No
286024581229.064.732.4A review of central 5-HT receptors and their function. N M Barnes, T SharpNeuropharmacology199910462127No
286112291229.022.7822.8Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Ricky W JohnstoneNat Rev Drug Discov200212120280No
286212291229.031.1231.1Polymer conjugates as anticancer nanomedicines. Ruth DuncanNat Rev Cancer200616900224No
286312291229.033.3533.4Infection in solid-organ transplant recipients. Jay A FishmanN Engl J Med200718094380No
286412291229.041.7741.8Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. Rui WangPhysiol Rev201222535897No
286536851228.3115.0238.3Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. B K Matuszewski, M L Constanzer, C M Chavez-EngAnal Chem200312964746Yes
286624551227.556.8728.4Peroxisome proliferator-activated receptors: nuclear control of metabolism. B Desvergne, W WahliEndocr Rev199910529898No
286724551227.543.421.7Stats: transcriptional control and biological impact. David E Levy, J E DarnellNat Rev Mol Cell Biol200212209125No
286824551227.562.3131.2An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Gary Aston-Jones, Jonathan D CohenAnnu Rev Neurosci200516022602No
286912271227.043.7343.7The LMS method for constructing normalized growth standards. T J ColeEur J Clin Nutr19902354692Yes
287024541227.039.3119.7A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. D Tautz, C PfeifleChromosoma19892476281Yes
287112271227.055.2255.2Continuous improvement as an ideal in health care. D M BerwickN Engl J Med19892909878Yes
287212271227.033.133.1Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. U MitzdorfPhysiol Rev19853880898No
287312271227.032.1232.1Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. P O SeglenExp Cell Res19734358115Yes
287424541227.048.8924.4Community structure in social and biological networks. M Girvan, M E J NewmanProc Natl Acad Sci U S A200212060727No
287512271227.040.0240.0Photoplethysmography and its application in clinical physiological measurement. John AllenPhysiol Meas200717322588No
287612261226.030.7230.7Endothelial-leukocyte adhesion molecules. M P BevilacquaAnnu Rev Immunol19938476577No
287724511225.554.0127.0Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. G K McMaster, G G CarmichaelProc Natl Acad Sci U S A197773185Yes
287824511225.563.2431.6Biology of incretins: GLP-1 and GIP. Laurie L Baggio, Daniel J DruckerGastroenterology200717498508No
287912251225.018.5218.5The concept of immunological surveillance. F M BurnetProg Exp Tumor Res19704921480No
288012251225.022.322.3Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. H E RuleyNature19836308473Yes
288112251225.025.3125.3MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. R N GermainCell19948293464No
288212251225.018.9619.0The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. G A RoseBull World Health Organ196213974778Yes
288312241224.026.6726.7Heterotrimeric G proteins: organizers of transmembrane signals. E J NeerCell19957834744No
288412241224.026.1226.1Microglia as a source and target of cytokines. Uwe-Karsten HanischGlia200212379902No
288536721224.0109.4136.5Health benefits of physical activity: the evidence. Darren E R Warburton, Crystal Whitney Nicol, Shannon S D BredinCMAJ200616534088No
288612231223.062.8562.9Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. K SatohClin Chim Acta1978719890Yes
288712231223.052.3252.3The Laboratory Rat: Relating Its Age With Human's. Pallav SenguptaInt J Prev Med201323930179Yes
288824441222.065.2632.6Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. M A Pfeffer, E BraunwaldCirculation19902138525No
288912221222.028.4628.5A likelihood approach to estimating phylogeny from discrete morphological character data. P O LewisSyst Biol200112116640Yes
289012221222.034.6434.6T follicular helper cell differentiation, function, and roles in disease. Shane CrottyImmunity201425367570No
289148851221.2273.6568.4Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. L A Papile, J Burstein, R Burstein, H KofflerJ Pediatr1978305471Yes
289224421221.075.4237.7Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J E Hixson, D T VernierJ Lipid Res19902341813Yes
289312211221.048.848.8Bone "mass" and the "mechanostat": a proposal. H M FrostAnat Rec19873688455Yes
289412211221.033.7633.8Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. F HeftiJ Neurosci19863746405Yes
289512211221.031.9131.9Measurement of feelings using visual analogue scales. R C AitkenProc R Soc Med19694899510No
289612211221.030.8230.8Neural systems for recognizing emotion. Ralph AdolphsCurr Opin Neurobiol200212015233No
289712211221.037.5137.5Evaluating the quality of medical care. 1966. Avedis DonabedianMilbank Q200516279964No
289812211221.037.1237.1Delirium in older persons. Sharon K InouyeN Engl J Med200616540616No
289912211221.028.7128.7Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. R Balfour SartorNat Clin Pract Gastroenterol Hepatol200616819502No
290012201220.045.5445.5A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. S T TiffanyPsychol Rev19902186423No
290112201220.044.4844.5Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants. R W BohannonAge Ageing19979143432Yes
290212201220.023.1323.1ChIP-seq: advantages and challenges of a maturing technology. Peter J ParkNat Rev Genet200919736561No
290312191219.023.5723.6Lipid rafts: elusive or illusive? Sean MunroCell200314622593No
290412191219.027.5727.6Production of recombinant protein therapeutics in cultivated mammalian cells. Florian M WurmNat Biotechnol200415529164No
290512181218.043.143.1Experience from a multicentre stroke register: a preliminary report. S HatanoBull World Health Organ19761088404Yes
290612181218.044.7144.7The P300 wave of the human event-related potential. T W PictonJ Clin Neurophysiol19921464675No
290712181218.028.5828.6Growth factors and cancer. S A AaronsonScience19911659742No
290812181218.036.0236.0Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. Louis B RiceJ Infect Dis200818419525No
290924351217.578.639.3Atomic structure and chemistry of human serum albumin. X M He, D C CarterNature19921630489Yes
291012171217.025.125.1Platelets in atherothrombosis. Zaverio M RuggeriNat Med200212411949No
291112171217.010.7510.8Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. J M Van RossumArch Int Pharmacodyn Ther196313996119Yes
291212161216.059.0659.1ROC methodology in radiologic imaging. C E MetzInvest Radiol19863095258No
291312161216.044.5144.5Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. S H SafeCrit Rev Toxicol19948037844No
291412161216.025.725.7Dendritic cells: unique leukocyte populations which control the primary immune response. D N HartBlood19979345009No
291512161216.022.1222.1Kinesin and dynein superfamily proteins and the mechanism of organelle transport. N HirokawaScience19989438838No
291636481216.061.5620.5A system for stable expression of short interfering RNAs in mammalian cells. Thijn R Brummelkamp, René Bernards, Reuven AgamiScience200211910072Yes
291712161216.030.7930.8Functionalized acenes and heteroacenes for organic electronics. John E AnthonyChem Rev200617165682Yes
291824321216.087.3343.7Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. John F Cryan, Timothy G DinanNat Rev Neurosci201222968153No
291912161216.067.2167.2ROS Are Good. Ron MittlerTrends Plant Sci201727666517No
292024311215.547.9924.0Molecular chaperones in the cytosol: from nascent chain to folded protein. F Ulrich Hartl, Manajit Hayer-HartlScience200211884745No
292124311215.518.839.4The Aggregation Of Blood Platelets. G V Born, M J CrossJ Physiol196314056485Yes
2922133691215.4343.0631.2Frailty in older adults: evidence for a phenotype. L P Fried, C M Tangen, J Walston, A B Newman, C Hirsch, J Gottdiener, T Seeman, R Tracy, W J Kop, G Burke, M A McBurnieJ Gerontol A Biol Sci Med Sci200111253156Yes
292312151215.027.2827.3Brain tumors. L M DeAngelisN Engl J Med200111150363No
292412151215.024.3824.4Basement membranes: structure, assembly and role in tumour angiogenesis. Raghu KalluriNat Rev Cancer200312778132No
292512141214.027.0527.1Translating cell biology into therapeutic advances in Alzheimer's disease. D J SelkoeNature199910392577No
292612141214.032.3232.3Akaike's information criterion in generalized estimating equations. W PanBiometrics200111252586Yes
292712141214.033.4733.5Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Antoine BecharaNat Neurosci200516251988No
292812131213.032.6632.7Levels of racism: a theoretic framework and a gardener's tale. C P JonesAm J Public Health200010936998Yes
292912121212.024.9324.9Morphogenetic roles of classic cadherins. M TakeichiCurr Opin Cell Biol19958573335No
293024221211.039.4119.7High resolution acrylamide gel electrophoresis of histones. S Panyim, R ChalkleyArch Biochem Biophys19695778650Yes
293112111211.029.0429.0Plant salt tolerance. J K ZhuTrends Plant Sci200111173290Yes
293212111211.034.7534.8High prevalence of vitamin D inadequacy and implications for health. Michael F HolickMayo Clin Proc200616529140No
293324221211.064.1832.1A neurotrophic model for stress-related mood disorders. Ronald S Duman, Lisa M MonteggiaBiol Psychiatry200616631126No
293424221211.086.5343.3Nitric oxide synthases: regulation and function. Ulrich Förstermann, William C SessaEur Heart J201221890489No
293512101210.029.3329.3Bcl-2 initiates a new category of oncogenes: regulators of cell death. S J KorsmeyerBlood19921498330No
293612101210.025.1425.1Caspase structure, proteolytic substrates, and function during apoptotic cell death. D W NicholsonCell Death Differ199910578171No
293712101210.034.3534.4Electrochemical glucose biosensors. Joseph WangChem Rev200818154363No
293824191209.572.6636.3Inflammatory mechanisms in obesity. Margaret F Gregor, Gökhan S HotamisligilAnnu Rev Immunol201121219177No
293936281209.3178.6259.5Assessing coping strategies: a theoretically based approach. C S Carver, M F Scheier, J K WeintraubJ Pers Soc Psychol19892926629Yes
294012091209.041.9942.0Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. A J AlpertJ Chromatogr19902324207Yes
294112091209.052.9352.9Inflammation, metaflammation and immunometabolic disorders. Gökhan S HotamisligilNature201728179656No
294212081208.028.6828.7Rapid and sensitive sequence comparison with FASTP and FASTA. W R PearsonMethods Enzymol19902156132Yes
294312081208.020.0720.1Mitotic kinases as regulators of cell division and its checkpoints. E A NiggNat Rev Mol Cell Biol200111413462No
294424161208.052.6826.3Toll-like receptors in innate immunity. Kiyoshi Takeda, Shizuo AkiraInt Immunol200515585605No
294512081208.033.733.7Water as an active constituent in cell biology. Philip BallChem Rev200818095715No
294624151207.5128.3864.2Sensitivity Analysis in Observational Research: Introducing the E-Value. Tyler J VanderWeele, Peng DingAnn Intern Med201728693043Yes
294760371207.4147.2129.4Jalview Version 2--a multiple sequence alignment editor and analysis workbench. Andrew M Waterhouse, James B Procter, David M A Martin, Michèle Clamp, Geoffrey J BartonBioinformatics200919151095Yes
294872431207.2135.0522.5Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T TuschlNature200111373684Yes
294912071207.038.1338.1Linkage map of Escherichia coli K-12, edition 7. B J BachmannMicrobiol Rev19836348505No
295012071207.048.4548.5Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. E H BeacheyJ Infect Dis19817014727No
295112071207.023.1123.1IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Yong-Jun LiuAnnu Rev Immunol200515771572No
295212071207.037.8937.9Clinical practice. Endometriosis. Linda C GiudiceN Engl J Med201020573927No
295312061206.031.5831.6Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Paul WillnerNeuropsychobiology200516037678No
295496471205.9249.4331.2A method and server for predicting damaging missense mutations. Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R SunyaevNat Methods201020354512Yes
295536161205.372.5224.2Large-scale analysis of the yeast proteome by multidimensional protein identification technology. M P Washburn, D Wolters, J R YatesNat Biotechnol200111231557Yes
295624101205.096.8448.4The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. R Näätänen, T PictonPsychophysiology19873615753Yes
295712051205.028.1928.2Intracellular protein topogenesis. G BlobelProc Natl Acad Sci U S A19806929499Yes
295824101205.059.9230.0Rising incidence of hepatocellular carcinoma in the United States. H B El-Serag, A C MasonN Engl J Med199910072408Yes
295912051205.051.4251.4Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation. Karimollah Hajian-TilakiCaspian J Intern Med201324009950No
296036141204.7101.7133.9Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. H King, R E Aubert, W H HermanDiabetes Care19989727886Yes
296112041204.029.2429.2The neuropathology of schizophrenia. A critical review of the data and their interpretation. P J HarrisonBrain199910219775No
296248131203.2111.9928.0Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. G L Wang, B H Jiang, E A Rue, G L SemenzaProc Natl Acad Sci U S A19957539918Yes
296324061203.074.1837.1A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. A Ennaceur, J DelacourBehav Brain Res19883228475Yes
296436081202.7113.5637.9Qualitative research in health care. Analysing qualitative data. C Pope, S Ziebland, N MaysBMJ200010625273No
296524051202.557.2128.6Principles of bioactive lipid signalling: lessons from sphingolipids. Yusuf A Hannun, Lina M ObeidNat Rev Mol Cell Biol200818216770No
296612021202.029.529.5Automatic quantitation of localized in vivo 1H spectra with LCModel. S W ProvencherNMR Biomed200111410943Yes
296724041202.082.6141.3Factors affecting wound healing. S Guo, L A DipietroJ Dent Res201020139336No
296848071201.8153.7338.4Validation of a combined comorbidity index. M Charlson, T P Szatrowski, J Peterson, J GoldJ Clin Epidemiol19947722560Yes
296912011201.040.0640.1Assay of intestinal disaccharidases. A DahlqvistAnal Biochem19685636962Yes
297012011201.021.3321.3Studies on phosphatidylcholine vesicles. Formation and physical characteristics. C HuangBiochemistry19695777332Yes
297112011201.025.6525.6The finer things in X-ray diffraction data collection. J W PflugrathActa Crystallogr D Biol Crystallogr199910531521Yes
297212011201.037.1937.2Sensorimotor integration in human postural control. R J PeterkaJ Neurophysiol200212205132Yes
297312011201.048.8648.9The variable nature of cognitive control: a dual mechanisms framework. Todd S BraverTrends Cogn Sci201222245618Yes
297436021200.786.4928.8Functional diversity of helper T lymphocytes. A K Abbas, K M Murphy, A SherNature19968893001No
297524001200.070.7535.4Recent advances in the phencyclidine model of schizophrenia. D C Javitt, S R ZukinAm J Psychiatry19911654746No
297624001200.064.1232.1Leukocyte-endothelial adhesion molecules. T M Carlos, J M HarlanBlood19947522621No
297712001200.027.1227.1Mitochondrial transport of cations: channels, exchangers, and permeability transition. P BernardiPhysiol Rev199910508231No
297812001200.024.5924.6Fibrotic disease and the T(H)1/T(H)2 paradigm. Thomas A WynnNat Rev Immunol200415286725No
297912001200.030.7830.8The complex role of estrogens in inflammation. Rainer H StraubEndocr Rev200717640948No
298012001200.050.4150.4The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults. L S RadloffJ Youth Adolesc199124265004Yes
298123991199.596.4148.2Unique features of long non-coding RNA biogenesis and function. Jeffrey J Quinn, Howard Y ChangNat Rev Genet201626666209No
298223991199.5101.5850.8The Warburg Effect: How Does it Benefit Cancer Cells? Maria V Liberti, Jason W LocasaleTrends Biochem Sci201626778478No
298311991199.038.1938.2The pathogenesis of sepsis. R C BoneAnn Intern Med19911872494No
298423981199.053.3826.7Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. T Hunter, B M SeftonProc Natl Acad Sci U S A19806246487Yes
298511991199.038.3938.4The Danish Register of Causes of Death. Karin Helweg-LarsenScand J Public Health201121775346Yes
298623971198.563.0731.5Imaging cognition II: An empirical review of 275 PET and fMRI studies. R Cabeza, L NybergJ Cogn Neurosci200010769304No
298711981198.052.1552.1Campylobacter enteritis: a "new" disease. M B SkirrowBr Med J1977871765Yes
298811981198.020.4620.5Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J O HolloszyJ Biol Chem19674290225Yes
298911981198.031.9531.9The emotional dog and its rational tail: a social intuitionist approach to moral judgment. J HaidtPsychol Rev200111699120Yes
299023961198.068.6134.3Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. Xiaobo Chen, Samuel S MaoChem Rev200717590053Yes
299123951197.5244.7122.3The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. Hussin A Rothan, Siddappa N ByrareddyJ Autoimmun202032113704No
299247891197.2132.1933.0Toxic potential of materials at the nanolevel. Andre Nel, Tian Xia, Lutz Mädler, Ning LiScience200616456071No
299347891197.2184.5646.1Predicting effective microRNA target sites in mammalian mRNAs. Vikram Agarwal, George W Bell, Jin-Wu Nam, David P BartelElife201526267216Yes
299411971197.041.0141.0The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. N M KaplanArch Intern Med19892662932No
299511971197.060.9460.9Rating scales to assess depression in school-aged children. M KovacsActa Paedopsychiatr19817025571Yes
299611971197.037.5337.5Socioeconomic status and obesity. Lindsay McLarenEpidemiol Rev200717478442No
299711961196.046.7646.8Geriatric Depression Scale. J A YesavagePsychopharmacol Bull19883249773Yes
299811961196.025.9125.9An overview of epithelio-mesenchymal transformation. E D HayActa Anat (Basel)19958714286No
299911941194.029.629.6Hereditary cancer, oncogenes, and antioncogenes. A G KnudsonCancer Res19852983882Yes
300011941194.027.9628.0Matrix proteoglycans: from molecular design to cellular function. R V IozzoAnnu Rev Biochem19989759499No
300111941194.031.0231.0Q-ball imaging. David S TuchMagn Reson Med200415562495Yes
300211941194.034.6334.6MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Amy E PasquinelliNat Rev Genet201222411466No
300311931193.048.948.9Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). S SafeCrit Rev Toxicol19902124811No
300411931193.036.7336.7Biosynthesis and metabolism of endothelium-derived nitric oxide. L J IgnarroAnnu Rev Pharmacol Toxicol19902188578No
300511931193.036.0236.0The mysteries of lipoprotein(a). G UtermannScience19892530631No
300611931193.044.5844.6The evolving concept of health literacy. Don NutbeamSoc Sci Med200818952344Yes
300747711192.8130.5832.6Measurement of the elastic properties and intrinsic strength of monolayer graphene. Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James HoneScience200818635798Yes
300823851192.547.723.9Of mice and not men: differences between mouse and human immunology. Javier Mestas, Christopher C W HughesJ Immunol200414978070No
300923851192.549.124.6NF-kappaB: linking inflammation and immunity to cancer development and progression. Michael Karin, Florian R GretenNat Rev Immunol200516175180No
301035771192.373.1824.4Toll-like receptors: critical proteins linking innate and acquired immunity. S Akira, K Takeda, T KaishoNat Immunol200111477402No
301111921192.032.8632.9Normalization of cell responses in cat striate cortex. D J HeegerVis Neurosci19921504027Yes
301211921192.020.820.8Stem cells: units of development, units of regeneration, and units in evolution. I L WeissmanCell200010647940No
301311921192.028.5328.5Metabolism and functions of glutathione in brain. R DringenProg Neurobiol200010880854No
301411911191.032.7632.8Diversity of group types, regulation, and function of phospholipase A2. E A DennisJ Biol Chem19948175726No
301511911191.033.2433.2Papillary and follicular thyroid carcinoma. M J SchlumbergerN Engl J Med19989445411No
301623821191.057.9529.0Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. M E Feder, G E HofmannAnnu Rev Physiol199910099689No
301711911191.052.752.7The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. W G DuncombeClin Chim Acta196414122498Yes
301811911191.030.5530.6Physiology and pathophysiology of purinergic neurotransmission. Geoffrey BurnstockPhysiol Rev200717429044No
301923811190.549.4224.7Atherosclerosis. the road ahead. C K Glass, J L WitztumCell200111239408No
302047611190.2239.2159.8Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. Xiang Wan, Wenqian Wang, Jiming Liu, Tiejun TongBMC Med Res Methodol201425524443Yes
302111901190.034.6434.6Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. W SieghartPharmacol Rev19957568326No
302211901190.033.933.9Atomic layer deposition: an overview. Steven M GeorgeChem Rev201019947596Yes
302323791189.545.3822.7Dynamic instability of microtubule growth. T Mitchison, M KirschnerNature19846504138Yes
302447561189.0137.0234.3Place navigation impaired in rats with hippocampal lesions. R G Morris, P Garrud, J N Rawlins, J O'KeefeNature19827088155Yes
302511891189.019.319.3Themes and variations on ubiquitylation. A M WeissmanNat Rev Mol Cell Biol200111265246No
302611891189.029.929.9Molecular genetics of colorectal cancer. Eric R FearonAnnu Rev Pathol201121090969No
302711891189.045.2845.3Glutathione synthesis. Shelly C LuBiochim Biophys Acta201322995213No
302823771188.561.1730.6Humans integrate visual and haptic information in a statistically optimal fashion. Marc O Ernst, Martin S BanksNature200211807554Yes
302923771188.569.5134.8Natural products as sources of new drugs over the last 25 years. David J Newman, Gordon M CraggJ Nat Prod200717309302No
3030106941188.2354.3739.4A novel potent vasoconstrictor peptide produced by vascular endothelial cells. M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T MasakiNature19882451132Yes
303123761188.049.1924.6Sequence logos: a new way to display consensus sequences. T D Schneider, R M StephensNucleic Acids Res19902172928Yes
303211881188.021.4521.4Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. D HanahanNature19852986015Yes
303311881188.030.1330.1Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. G BodenDiabetes19978971073No
303423761188.043.9222.0Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. C Li, W H WongProc Natl Acad Sci U S A200111134512Yes
303511881188.023.7623.8Protein tyrosine phosphatases: from genes, to function, to disease. Nicholas K TonksNat Rev Mol Cell Biol200617057753No
303659361187.2141.1228.2Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L CoffmanJ Immunol19862419430Yes
303723741187.0111.9156.0Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. J D Peuler, G A JohnsonLife Sci1977904439Yes
303823741187.066.2933.1New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. Jonathan B Baell, Georgina A HollowayJ Med Chem201020131845Yes
303923731186.584.0742.0Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. A Fabiato, F FabiatoJ Physiol (Paris)1979533865Yes
304011861186.034.8134.8The structure of common mental disorders. R F KruegerArch Gen Psychiatry199910530634Yes
304111861186.059.1259.1The new statistics: why and how. Geoff CummingPsychol Sci201424220629Yes
304259291185.8198.6839.7Posttraumatic stress disorder in the National Comorbidity Survey. R C Kessler, A Sonnega, E Bromet, M Hughes, C B NelsonArch Gen Psychiatry19957492257Yes
304347421185.5194.0848.5QUAST: quality assessment tool for genome assemblies. Alexey Gurevich, Vladislav Saveliev, Nikolay Vyahhi, Glenn TeslerBioinformatics201323422339Yes
3044165951185.4354.025.3Crystallography & NMR system: A new software suite for macromolecular structure determination. A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L WarrenActa Crystallogr D Biol Crystallogr19989757107Yes
304511851185.052.0652.1Presynaptic regulation of the release of catecholamines. S Z LangerPharmacol Rev19806267618Yes
304611851185.023.1923.2A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. Xuemei ChenScience200412893888Yes
304711851185.024.0724.1Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. Sean B CarrollCell200818614008Yes
304823691184.561.1230.6Statistical tests of neutrality of mutations. Y X Fu, W H LiGenetics19938454210Yes
304935521184.0104.4334.8The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. G Blessed, B E Tomlinson, M RothBr J Psychiatry19685662937Yes
305011841184.026.8326.8Hybridization of denatured RNA transferred or dotted nitrocellulose paper. P S ThomasMethods Enzymol19836194404Yes
305123681184.095.1147.6Rapid procedure for detection and isolation of large and small plasmids. C I Kado, S T LiuJ Bacteriol19817009583Yes
305211841184.030.0530.1Disorders of iron metabolism. N C AndrewsN Engl J Med199910607817No
305311841184.023.6423.6Up on the tightrope: natural killer cell activation and inhibition. Lewis L LanierNat Immunol200818425106No
305411841184.00.00.0Histological demonstration of mucin after periodic acid. J F A McMANUSNature194620995486Yes
305535501183.372.0524.0Cellular survival: a play in three Akts. S R Datta, A Brunet, M E GreenbergGenes Dev199910579998No
305611831183.026.2626.3The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. S J CollinsBlood19873311197No
305711831183.023.4323.4Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. Harold F DvorakJ Clin Oncol200212409337No
305811831183.034.234.2The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. R G PertweeBr J Pharmacol200817828291No
305923661183.071.6735.8Plasmonics for improved photovoltaic devices. Harry A Atwater, Albert PolmanNat Mater201020168344Yes
306047291182.2132.5733.1AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang GuanNat Cell Biol201121258367Yes
3061189131182.1542.6733.9New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). E A Eisenhauer, P Therasse, J Bogaerts, L H Schwartz, D Sargent, R Ford, J Dancey, S Arbuck, S Gwyther, M Mooney, L Rubinstein, L Shankar, L Dodd, R Kaplan, D Lacombe, J VerweijEur J Cancer200919097774No
306211821182.00.00.0Voluntary strength and fatigue. P A MertonJ Physiol195413152698Yes
306311821182.025.6725.7Simple model of spiking neurons. E M IzhikevichIEEE Trans Neural Netw200318244602Yes
306411821182.054.7154.7Salience processing and insular cortical function and dysfunction. Lucina Q UddinNat Rev Neurosci201525406711No
306523631181.565.1832.6Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. R G Phillips, J E LeDouxBehav Neurosci19921590953Yes
306611811181.045.245.2Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. H V GelboinPhysiol Rev19807001511No
306711811181.036.5236.5Peritonectomy procedures. P H SugarbakerAnn Surg19957826158Yes
306811811181.036.1936.2The somatic marker hypothesis and the possible functions of the prefrontal cortex. A R DamasioPhilos Trans R Soc Lond B Biol Sci19968941953No
306911811181.032.4432.4The stress response to trauma and surgery. J P DesboroughBr J Anaesth200010927999No
307023621181.030.2115.1Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. R R Guillard, J H RytherCan J Microbiol196213902807Yes
307111811181.020.7520.8Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. G D WinterNature196214007593Yes
307223621181.048.524.2The mammalian unfolded protein response. Martin Schröder, Randal J KaufmanAnnu Rev Biochem200515952902No
307311801180.065.565.5Nontuberculous mycobacteria and associated diseases. E WolinskyAm Rev Respir Dis1979369415No
307423591179.588.044.0Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. H Esterbauer, K H CheesemanMethods Enzymol19902233308Yes
307523581179.068.1534.1The low-density lipoprotein pathway and its relation to atherosclerosis. J L Goldstein, M S BrownAnnu Rev Biochem1977197883No
307611791179.038.838.8Interleukin-1 and the pathogenesis of the acute-phase response. C A DinarelloN Engl J Med19846208485No
307711791179.047.1347.1The anatomy of stages of change. A BanduraAm J Health Promot199710170438No
307811791179.028.4328.4Targeting DNA topoisomerase II in cancer chemotherapy. John L NitissNat Rev Cancer200919377506No
307923571178.5101.9751.0Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. P R Hunter, M A GastonJ Clin Microbiol19883069867Yes
308047131178.2147.7836.9Epidemiology and causes of preterm birth. Robert L Goldenberg, Jennifer F Culhane, Jay D Iams, Roberto RomeroLancet200818177778No
308158901178.0190.7638.2Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L WitztumN Engl J Med19892648148No
308211781178.038.5538.5Checklists for improving rigour in qualitative research: a case of the tail wagging the dog? R S BarbourBMJ200111337448No
308311781178.025.4325.4The myofibroblast in wound healing and fibrocontractive diseases. G GabbianiJ Pathol200312845617No
308458891177.8287.7257.5Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W StittJ Rheumatol19883068365Yes
308523551177.572.3636.2Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. A Warshel, M LevittJ Mol Biol1976985660Yes
308623551177.550.7725.4Lymphocyte homing and homeostasis. E C Butcher, L J PickerScience19968600538No
308723551177.548.624.3Toll-like receptors in the induction of the innate immune response. A Aderem, R J UlevitchNature200010963608No
308811771177.034.5434.5Analyzing the mosaic structure of genes. J M SmithJ Mol Evol19921556748No
308911771177.072.9973.0Impingement lesions. C S NeerClin Orthop Relat Res19836825348Yes
309023541177.076.3638.2Physiological parameters in laboratory animals and humans. B Davies, T MorrisPharm Res19938378254No
309111771177.028.1528.1A tension-based theory of morphogenesis and compact wiring in the central nervous system. D C Van EssenNature19979002514Yes
309211771177.030.5830.6The neurobiology of stress: from serendipity to clinical relevance. B S McEwenBrain Res200011119695No
309311771177.025.7525.8How neutrophils kill microbes. Anthony W SegalAnnu Rev Immunol200515771570No
309423541177.052.4826.2Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Jing Yang, Robert A WeinbergDev Cell200818539112No
309535311177.090.7430.2Methods in mammalian autophagy research. Noboru Mizushima, Tamotsu Yoshimori, Beth LevineCell201020144757Yes
309682331176.1162.5723.2Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P SpeedBiostatistics200312925520Yes
309723521176.076.4338.2Quantitative determination of serum triglycerides by the use of enzymes. G Bucolo, H DavidClin Chem19734703655Yes
309811761176.030.8130.8Bacteroides: the good, the bad, and the nitty-gritty. Hannah M WexlerClin Microbiol Rev200717934076No
3099105841176.0273.8730.4MolProbity: all-atom structure validation for macromolecular crystallography. Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C RichardsonActa Crystallogr D Biol Crystallogr201020057044Yes
310011761176.046.0546.0A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading. Cathy J PriceNeuroimage201222584224No
310147021175.5105.2426.3Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. J E Walker, M Saraste, M J Runswick, N J GayEMBO J19826329717Yes
310211751175.034.4734.5A human model of gastric carcinogenesis. P CorreaCancer Res19883288329No
310311751175.045.8445.8Freezing of living cells: mechanisms and implications. P MazurAm J Physiol19846383068No
310411751175.024.1224.1Apoptosis in neurodegenerative disorders. M P MattsonNat Rev Mol Cell Biol200011253364No
310511751175.00.00.0Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. P B MedawarBr J Exp Pathol194818865105Yes
310623491174.546.023.0Multiple nuclear factors interact with the immunoglobulin enhancer sequences. R Sen, D BaltimoreCell19863091258Yes
310723491174.542.221.1Hedgehog signaling in animal development: paradigms and principles. P W Ingham, A P McMahonGenes Dev200111731473No
310823491174.566.433.2Heterogeneous photocatalyst materials for water splitting. Akihiko Kudo, Yugo MisekiChem Soc Rev200919088977Yes
310935231174.3162.7354.2Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. F Guillemin, C Bombardier, D BeatonJ Clin Epidemiol19938263569No
311011741174.040.5640.6An approach for the treatment of penile carcinoma. R M CabanasCancer1977837331Yes
311111741174.037.8737.9Agents that increase the permeability of the outer membrane. M VaaraMicrobiol Rev19921406489No
311211741174.026.1126.1Cadherins: a molecular family important in selective cell-cell adhesion. M TakeichiAnnu Rev Biochem19902197976No
311311741174.032.3132.3The induction of pain: an integrative review. M J MillanProg Neurobiol19999987804No
311411741174.00.00.0A production of amino acids under possible primitive earth conditions. S L MillerScience195313056598Yes
311511741174.039.8739.9Volumetric modulated arc therapy: IMRT in a single gantry arc. Karl OttoMed Phys200818293586Yes
311635191173.090.0630.0Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. C R Woese, O Kandler, M L WheelisProc Natl Acad Sci U S A19902112744Yes
311711731173.041.3841.4Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. M A LempCLAO J19958565190No
311823461173.061.5430.8The ubiquitin code. David Komander, Michael RapeAnnu Rev Biochem201222524316No
311923451172.5201.57100.8Radiological demarcation of cemented sockets in total hip replacement. J G DeLee, J CharnleyClin Orthop Relat Res1976991504Yes
312023451172.556.1828.1Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects. R P Rao, D H BallardNat Neurosci199910195184Yes
312123441172.073.2536.6Antiseptics and disinfectants: activity, action, and resistance. G McDonnell, A D RussellClin Microbiol Rev19999880479No
312211721172.043.6943.7Energy metabolism in the liver. Liangyou RuiCompr Physiol201424692138No
312323431171.574.5937.3Solubilization of membranes by detergents. A Helenius, K SimonsBiochim Biophys Acta19751091302No
312411711171.030.7430.7Pathogenesis of dengue: challenges to molecular biology. S B HalsteadScience19883277268No
312511711171.021.8421.8Shrinkage necrosis: a distinct mode of cellular death. J F KerrJ Pathol19714108566Yes
312611711171.024.2324.2Microsatellites: simple sequences with complex evolution. Hans EllegrenNat Rev Genet200415153996No
312735121170.784.8628.3Astrocyte-endothelial interactions at the blood-brain barrier. N Joan Abbott, Lars Rönnbäck, Elisabeth HanssonNat Rev Neurosci200616371949No
312835101170.070.4623.5Predicting coiled coils from protein sequences. A Lupas, M Van Dyke, J StockScience19912031185Yes
312935101170.0116.9539.0Hepatocellular carcinoma. Alejandro Forner, Josep M Llovet, Jordi BruixLancet201222353262No
313035091169.787.9229.3Use and abuse of HOMA modeling. Tara M Wallace, Jonathan C Levy, David R MatthewsDiabetes Care200415161807No
313123391169.536.8418.4Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. J D McGhee, P H von HippelJ Mol Biol19744416620Yes
313223381169.052.4826.2Adaptive protein evolution at the Adh locus in Drosophila. J H McDonald, M KreitmanNature19911904993Yes
313311691169.038.7538.8Enhancing the quality and credibility of qualitative analysis. M Q PattonHealth Serv Res199910591279No
313423381169.076.3938.2Efficacy of the Theory of Planned Behaviour: a meta-analytic review. C J Armitage, M ConnerBr J Soc Psychol200111795063Yes
313523371168.563.1831.6A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions. Yan Zhao, Donald G TruhlarJ Chem Phys200617129083Yes
313670101168.3199.4833.2Genome engineering using the CRISPR-Cas9 system. F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng ZhangNat Protoc201324157548Yes
313711681168.030.830.86-Hydroxy-dopamine induced degeneration of central monoamine neurons. U UngerstedtEur J Pharmacol19685718510Yes
313811681168.034.8534.9Low-molecular-weight heparins. J I WeitzN Engl J Med19979278467No
313911681168.00.00.0A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. J B BrownBiochem J195514389222Yes
314011681168.022.8122.8Telomeres and human disease: ageing, cancer and beyond. Maria A BlascoNat Rev Genet200516136653No
314123361168.070.9535.5Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. S Geman, D GemanIEEE Trans Pattern Anal Mach Intell198422499653Yes
3142116731167.3423.642.4The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gøtzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David MoherBMJ200919622552No
314346691167.2132.0833.0Biological identifications through DNA barcodes. Paul D N Hebert, Alina Cywinska, Shelley L Ball, Jeremy R deWaardProc Biol Sci200312614582Yes
314411671167.031.331.3Presynaptic regulation of catecholamine release. S Z LangerBiochem Pharmacol19744617579No
314511671167.0106.38106.4The analysis of errors in orthodontic measurements. W J HoustonAm J Orthod19836573846Yes
314611671167.035.7235.7Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. M E BoutonPsychol Bull19938346330No
314711671167.00.00.0A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. M G BuonocoreJ Dent Res195513271655Yes
314811671167.00.00.0The cytoarchitectonic organization of the spinal cord in the cat. B RexedJ Comp Neurol195214946260Yes
314958331166.6216.1543.2DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates. O Folmer, M Black, W Hoeh, R Lutz, R VrijenhoekMol Mar Biol Biotechnol19947881515Yes
315046661166.5108.4927.1Base-calling of automated sequencer traces using phred. I. Accuracy assessment. B Ewing, L Hillier, M C Wendl, P GreenGenome Res19989521921Yes
315134991166.378.7226.2Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. A L Shapiro, E Viñuela, J V MaizelBiochem Biophys Res Commun19674861258Yes
315211661166.035.4635.5Platelet-rich plasma: evidence to support its use. Robert E MarxJ Oral Maxillofac Surg200415085519No
315311661166.044.8444.8The biogenesis and emerging roles of circular RNAs. Ling-Ling ChenNat Rev Mol Cell Biol201626908011Yes
315411651165.035.7335.7MOPAC: a semiempirical molecular orbital program. J J StewartJ Comput Aided Mol Des19902197373No
315511651165.022.122.1Contingent genetic regulatory events in T lymphocyte activation. G R CrabtreeScience19892783497Yes
315634951165.073.2524.4Computer visualization of three-dimensional image data using IMOD. J R Kremer, D N Mastronarde, J R McIntoshJ Struct Biol19968742726Yes
315711651165.031.7231.7Pharmacology of cannabinoid CB1 and CB2 receptors. R G PertweePharmacol Ther19979336020No
315823301165.049.2224.6Functions of lipid rafts in biological membranes. D A Brown, E LondonAnnu Rev Cell Dev Biol19989891780No
315911651165.031.2131.2Core affect and the psychological construction of emotion. James A RussellPsychol Rev200312529060No
316011651165.037.737.7On the law of effect. R J HerrnsteinJ Exp Anal Behav197016811440Yes
316146601165.0124.1331.0Organometal halide perovskites as visible-light sensitizers for photovoltaic cells. Akihiro Kojima, Kenjiro Teshima, Yasuo Shirai, Tsutomu MiyasakaJ Am Chem Soc200919366264Yes
316246591164.889.5822.4Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. L Alexopoulou, A C Holt, R Medzhitov, R A FlavellNature200111607032Yes
316369851164.2237.2839.5The occurrence of sleep-disordered breathing among middle-aged adults. T Young, M Palta, J Dempsey, J Skatrud, S Weber, S BadrN Engl J Med19938464434Yes
316411641164.023.7523.8Biogenic amines and the states of sleep. M JouvetScience19694303225No
316511641164.011.5111.5Pathologic anatomy of the pancreas in juvenile diabetes mellitus. W GeptsDiabetes19655318831Yes
316611641164.022.0222.0Microarray data normalization and transformation. John QuackenbushNat Genet200212454644No
316711641164.031.3631.4Production and scavenging of reactive oxygen species in chloroplasts and their functions. Kozi AsadaPlant Physiol200616760493Yes
316823271163.595.6947.8Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. Ian Janssen, Allana G LeblancInt J Behav Nutr Phys Act201020459784Yes
3169104711163.4270.2230.0Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Cole Trapnell, Brian A Williams, Geo Pertea, Ali Mortazavi, Gordon Kwan, Marijke J van Baren, Steven L Salzberg, Barbara J Wold, Lior PachterNat Biotechnol201020436464Yes
317034901163.377.025.7Hepatocellular carcinoma. Josep M Llovet, Andrew Burroughs, Jordi BruixLancet200314667750No
317111631163.041.9542.0The case for motivated reasoning. Z KundaPsychol Bull19902270237No
317211631163.033.1933.2What is synergy? M C BerenbaumPharmacol Rev19892692037No
317311631163.036.6836.7Molecular biology of steroid hormone synthesis. W L MillerEndocr Rev19883061784No
317411631163.034.7534.8Effect of anoxia on ion distribution in the brain. A J HansenPhysiol Rev19853880896No
317523261163.060.1830.1Verification of protein structures: patterns of nonbonded atomic interactions. C Colovos, T O YeatesProtein Sci19938401235Yes
317611631163.030.5630.6Epidemiology of women and depression. Ronald C KesslerJ Affect Disord200312646294Yes
317711631163.051.151.1Preliminary Trial Of Carisoprodol In Multiple Sclerosis. B AshworthPractitioner196414143329Yes
317834881162.7138.5146.2Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. A DeLean, P J Munson, D RodbardAm J Physiol1978686171Yes
317923251162.571.4635.7bold: The Barcode of Life Data System (http://www.barcodinglife.org). Sujeevan Ratnasingham, Paul D N HebertMol Ecol Notes200718784790Yes
318034871162.3118.8339.6The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting. C Kirschbaum, K M Pirke, D H HellhammerNeuropsychobiology19938255414Yes
318111621162.034.2634.3Determinants of tumor blood flow: a review. R K JainCancer Res19883282647No
318211621162.025.825.8Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. H J DargieLancet200111356434Yes
318311621162.027.927.9Context and behavioral processes in extinction. Mark E BoutonLearn Mem200415466298No
318411621162.055.9556.0When to use the Bonferroni correction. Richard A ArmstrongOphthalmic Physiol Opt201424697967No
318523231161.579.5539.8The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. G P Chrousos, P W GoldJAMA19921538563No
318611611161.026.7726.8Neurons with graded response have collective computational properties like those of two-state neurons. J J HopfieldProc Natl Acad Sci U S A19846587342Yes
318711611161.039.1939.2beta-Lactamases in laboratory and clinical resistance. D M LivermoreClin Microbiol Rev19958665470No
318811611161.026.6926.7Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. William C AirdCirc Res200717272818No
318911601160.022.0722.1The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. Y YardenEur J Cancer200111597398No
319011601160.023.3523.4Liver regeneration: from myth to mechanism. Rebecca TaubNat Rev Mol Cell Biol200415459664No
319123201160.083.9742.0Severe sepsis and septic shock. Derek C Angus, Tom van der PollN Engl J Med201323984731No
319223201160.091.5745.8Kraken: ultrafast metagenomic sequence classification using exact alignments. Derrick E Wood, Steven L SalzbergGenome Biol201424580807Yes
319323191159.550.2825.1Blinded by the Light: The Growing Complexity of p53. Karen H Vousden, Carol PrivesCell200919410540No
319411591159.035.9536.0Strategies of antioxidant defense. H SiesEur J Biochem19937688300No
319511591159.021.3621.4Biological robustness. Hiroaki KitanoNat Rev Genet200415520792No
319634751158.384.6328.2High resolution two-dimensional electrophoresis of basic as well as acidic proteins. P Z O'Farrell, H M Goodman, P H O'FarrellCell197723215Yes
319711581158.014.7114.7Central dogma of molecular biology. F CrickNature19704913914No
319811581158.022.0422.0RNA metabolism in the HeLa cell nucleus. S PenmanJ Mol Biol19665961144Yes
319911581158.050.6550.6Coping theory and research: past, present, and future. R S LazarusPsychosom Med19938346332No
320023161158.047.4623.7Learning the parts of objects by non-negative matrix factorization. D D Lee, H S SeungNature199910548103Yes
320123161158.053.9527.0Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Josep M Llovet, Jordi BruixHepatology200312540794No
320223161158.053.4726.7Regulation of wound healing by growth factors and cytokines. Sabine Werner, Richard GrosePhysiol Rev200312843410No
320311581158.017.4417.4The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. R E Hope-SimpsonProc R Soc Med196514267505Yes
320411581158.038.5738.6Mediators and mechanisms of change in psychotherapy research. Alan E KazdinAnnu Rev Clin Psychol200717716046No
320523151157.549.5524.8Defining the role of mTOR in cancer. David A Guertin, David M SabatiniCancer Cell200717613433No
320611571157.052.4952.5The problem with the phrase women and minorities: intersectionality-an important theoretical framework for public health. Lisa BowlegAm J Public Health201222594719Yes
320734701156.7146.8448.9Measurement of health status. Ascertaining the minimal clinically important difference. R Jaeschke, J Singer, G H GuyattControl Clin Trials19892691207Yes
320857791155.8108.221.6The protein kinase complement of the human genome. G Manning, D B Whyte, R Martinez, T Hunter, S SudarsanamScience200212471243No
320934671155.7107.2635.8Evaluating the public health impact of health promotion interventions: the RE-AIM framework. R E Glasgow, T M Vogt, S M BolesAm J Public Health199910474547No
321023111155.554.0127.0Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Julie A Law, Steven E JacobsenNat Rev Genet201020142834No
321111551155.028.3128.3The epidemiologic transition. A theory of the epidemiology of population change. A R OmranMilbank Mem Fund Q19715155251Yes
321211551155.026.8126.8Amyloid, the presenilins and Alzheimer's disease. J HardyTrends Neurosci19979106355No
321311551155.037.8737.9Starting at the beginning: an introduction to coefficient alpha and internal consistency. David L StreinerJ Pers Assess200312584072Yes
321411551155.00.00.0Observations on the isolated phrenic nerve diaphragm preparation of the rat. E BulbringBr J Pharmacol Chemother194620999334Yes
321523091154.566.7333.4Excitatory amino acids as a final common pathway for neurologic disorders. S A Lipton, P A RosenbergN Engl J Med19947905600No
321623091154.572.4836.2The reward circuit: linking primate anatomy and human imaging. Suzanne N Haber, Brian KnutsonNeuropsychopharmacology201019812543No
321711541154.012.8812.9Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J AltmanJ Comp Neurol19695361244Yes
321823081154.043.8621.9NF-kappaB at the crossroads of life and death. Michael Karin, Anning LinNat Immunol200211875461No
321911541154.024.3724.4The advantages and disadvantages of being polyploid. Luca ComaiNat Rev Genet200516304599No
322023071153.564.3832.2Growth of a rat neuroblastoma cell line in serum-free supplemented medium. J E Bottenstein, G H SatoProc Natl Acad Sci U S A1979284369Yes
322123071153.546.4423.2A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. N C Andrews, D V FallerNucleic Acids Res19912041787Yes
322223071153.536.4218.2Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. R W Butcher, E W SutherlandJ Biol Chem196213875173Yes
322346131153.2174.1243.5Near-optimal probabilistic RNA-seq quantification. Nicolas L Bray, Harold Pimentel, Páll Melsted, Lior PachterNat Biotechnol201627043002Yes
322457651153.0163.732.7Quantitative assessment of tactile allodynia in the rat paw. S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L YakshJ Neurosci Methods19947990513Yes
322511531153.024.2524.2Stem cells in the central nervous system. R McKayScience19979082987No
322611531153.022.0722.1Mechanisms and consequences of activation of protein kinase B/Akt. J DownwardCurr Opin Cell Biol19989561851No
322711531153.025.1725.2G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. Jeffery T DavisAngew Chem Int Ed Engl200414755695No
3228115281152.8291.0629.1Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. M Dominici, K Le Blanc, I Mueller, I Slaper-Cortenbach, Fc Marini, Ds Krause, Rj Deans, A Keating, Dj Prockop, Em HorwitzCytotherapy200616923606Yes
322923051152.566.6233.3Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. P Brugada, J BrugadaJ Am Coll Cardiol19921309182Yes
323023051152.570.9335.5Role of oxidized low density lipoprotein in atherogenesis. J L Witztum, D SteinbergJ Clin Invest19911752940No
323111521152.019.8419.8Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. M S WoldAnnu Rev Biochem19979242902No
323234561152.091.330.4Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Dunyaporn Trachootham, Jerome Alexandre, Peng HuangNat Rev Drug Discov200919478820No
323334541151.381.0127.0Prediction of total genetic value using genome-wide dense marker maps. T H Meuwissen, B J Hayes, M E GoddardGenetics200111290733Yes
323411511151.027.2727.3Selective coronary arteriography. I. A percutaneous transfemoral technic. M P JudkinsRadiology19676048074Yes
323511511151.024.3224.3Epstein-Barr virus infection. J I CohenN Engl J Med200010944566No
323623021151.047.9424.0Protein aggregation and neurodegenerative disease. Christopher A Ross, Michelle A PoirierNat Med200415272267No
323711511151.035.2735.3A practical solution to the pervasive problems of p values. Eric-Jan WagenmakersPsychon Bull Rev200718087943Yes
323834531151.0103.5434.5SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building. Manolo Gouy, Stéphane Guindon, Olivier GascuelMol Biol Evol201019854763Yes
323923011150.556.5328.3Plasminogen: purification from human plasma by affinity chromatography. D G Deutsch, E T MertzScience19705475635Yes
324023011150.576.7838.4Pharmaceuticals and personal care products in the environment: agents of subtle change? C G Daughton, T A TernesEnviron Health Perspect199910592150No
324123011150.543.5421.8Rho GTPases: biochemistry and biology. Aron B Jaffe, Alan HallAnnu Rev Cell Dev Biol200516212495No
324211501150.036.036.0Relations between the statistics of natural images and the response properties of cortical cells. D J FieldJ Opt Soc Am A19873430225Yes
324311501150.00.00.0A sensitive method for the assay of 5-hydroxytryptamine. J R VaneBr J Pharmacol Chemother195713460242Yes
324411491149.031.3931.4Leishmaniasis. B L HerwaldtLancet199910513726No
324511491149.00.00.0The perceptron: a probabilistic model for information storage and organization in the brain. F RosenblattPsychol Rev195813602029Yes
324622971148.551.7425.9Shape-controlled synthesis of gold and silver nanoparticles. Yugang Sun, Younan XiaScience200212481134Yes
324711481148.033.0233.0Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. D B ClewellJ Bacteriol19724336693Yes
324811481148.029.4229.4The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. R A JainBiomaterials200011055295No
324911481148.024.7324.7Serine protease mechanism and specificity. Lizbeth HedstromChem Rev200212475199No
325011481148.022.1322.1Regulation of cadherin-mediated adhesion in morphogenesis. Barry M GumbinerNat Rev Mol Cell Biol200516025097No
325111481148.027.9628.0Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. Christof M NiemeyerAngew Chem Int Ed Engl200129712109No
325222951147.567.2333.6Nitric oxide synthases in mammals. R G Knowles, S MoncadaBiochem J19947510950No
325311471147.031.9431.9DNA topoisomerases. M GellertAnnu Rev Biochem19816267993No
325411471147.00.00.0The powerful placebo. H K BeecherJ Am Med Assoc195513271123Yes
325511471147.041.1841.2Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls? Fay B HorakAge Ageing200616926210No
325622941147.093.5346.8Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Ulrich M Zanger, Matthias SchwabPharmacol Ther201323333322No
325722931146.566.7533.4A rating scale for extrapyramidal side effects. G M Simpson, J W AngusActa Psychiatr Scand Suppl19704917967Yes
325822931146.550.5525.3Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. N Sreerama, R W WoodyAnal Biochem200011112271Yes
325922931146.550.3825.2Esophageal cancer. Peter C Enzinger, Robert J MayerN Engl J Med200314657432No
326022931146.554.227.1Endometriosis. Linda C Giudice, Lee C KaoLancet200415541453No
326111461146.031.131.1Diseases of the mitochondrial DNA. D C WallaceAnnu Rev Biochem19921497308No
326211461146.039.239.2Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases. K TamuraMol Biol Evol19921630306Yes
326311461146.048.2848.3A spreading-activation theory of retrieval in sentence production. G S DellPsychol Rev19863749399Yes
326411461146.027.7527.8Mode of action of membrane active antimicrobial peptides. Yechiel ShaiBiopolymers200212491537No
326545821145.5110.9527.7Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. H Nielsen, J Engelbrecht, S Brunak, G von HeijneProtein Eng19979051728Yes
326622911145.567.3233.7The capacity of visual working memory for features and conjunctions. S J Luck, E K VogelNature19979384378Yes
326780161145.1279.7140.0Metagenomic biomarker discovery and explanation. Nicola Segata, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis HuttenhowerGenome Biol201121702898Yes
326822901145.0109.0254.5Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. S F Dworkin, L LeRescheJ Craniomandib Disord19921298767No
326922901145.068.3834.2Multiple significance tests: the Bonferroni method. J M Bland, D G AltmanBMJ19957833759Yes
327011451145.07.077.1A New Serum Type System In Man--The Lp System. K BergActa Pathol Microbiol Scand196314064818Yes
327111451145.024.0824.1Version 1.2 of the Crystallography and NMR system. Axel T BrungerNat Protoc200718007608Yes
327234341144.791.5930.5Matrix metalloproteinases: regulators of the tumor microenvironment. Kai Kessenbrock, Vicki Plaks, Zena WerbCell201020371345No
327334331144.395.6131.9Regulation of cancer cell metabolism. Rob A Cairns, Isaac S Harris, Tak W MakNat Rev Cancer201121258394No
327411441144.045.9245.9Radioimmunological determination of human C-peptide in serum. L G HedingDiabetologia19751239396Yes
327511441144.042.0142.0Omega-3 fatty acids in health and disease and in growth and development. A P SimopoulosAm J Clin Nutr19911908631No
327622881144.089.2544.6A simple method to assess exercise behavior in the community. G Godin, R J ShephardCan J Appl Sport Sci19854053261Yes
327711441144.032.9833.0An improved fluorometric assay for DNA. R T HinegardnerAnal Biochem19715544593Yes
327811441144.022.3522.4Inferences, questions and possibilities in Toll-like receptor signalling. Bruce BeutlerNature200415241424No
327922881144.061.1130.6BODIPY dyes and their derivatives: syntheses and spectroscopic properties. Aurore Loudet, Kevin BurgessChem Rev200717924696Yes
328022881144.068.4734.2Software survey: VOSviewer, a computer program for bibliometric mapping. Nees Jan van Eck, Ludo WaltmanScientometrics201020585380Yes
328111441144.032.7832.8Rethinking schizophrenia. Thomas R InselNature201021068826No
328234311143.787.8829.3The widespread regulation of microRNA biogenesis, function and decay. Jacek Krol, Inga Loedige, Witold FilipowiczNat Rev Genet201020661255No
328322871143.547.0323.5Plant pathogens and integrated defence responses to infection. J L Dangl, J D JonesNature200111459065No
328422871143.567.8533.9Type 2 diabetes as an inflammatory disease. Marc Y Donath, Steven E ShoelsonNat Rev Immunol201121233852No
328534291143.0107.8936.0Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. G M Wahl, M Stern, G R StarkProc Natl Acad Sci U S A1979291033Yes
328611431143.033.2533.2Animal mitochondrial DNA: structure and evolution. D R WolstenholmeInt Rev Cytol19921452431No
328711431143.028.7228.7Two-stage model of memory trace formation: a role for "noisy" brain states. G BuzsákiNeuroscience19892687720No
328811431143.042.742.7Molecular aspects of ligand binding to serum albumin. U Kragh-HansenPharmacol Rev19817027277No
328911431143.00.00.0Fertilizing capacity of spermatozoa deposited into the fallopian tubes. M C ChangNature195114882325Yes
329034281142.7217.0172.3Production, use, and fate of all plastics ever made. Roland Geyer, Jenna R Jambeck, Kara Lavender LawSci Adv201728776036Yes
329122851142.548.0924.0Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Nahum Sonenberg, Alan G HinnebuschCell200919239892No
329268531142.2198.1733.0The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis. A Miyake, N P Friedman, M J Emerson, A H Witzki, A Howerter, T D WagerCogn Psychol200010945922Yes
329311421142.016.616.6Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. R J PenningtonBiochem J196113734134Yes
329411411141.033.3433.3Reducing children's television viewing to prevent obesity: a randomized controlled trial. T N RobinsonJAMA199910546696Yes
329511411141.021.3521.4Diffusion-in-gel methods for immunological analysis. II. O OuchterlonyProg Allergy196214482809Yes
329611411141.029.9730.0A theory of magnitude: common cortical metrics of time, space and quantity. Vincent WalshTrends Cogn Sci200314585444Yes
329711411141.048.7748.8The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review. Erik G WillcuttNeurotherapeutics201222976615No
329811411141.057.4557.5The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease. Costantino IadecolaNeuron201728957666No
329922811140.544.4422.2Homeobox genes and axial patterning. W McGinnis, R KrumlaufCell19921346368No
330011401140.040.4140.4Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. W A CatterallAnnu Rev Pharmacol Toxicol19806247957No
330111401140.025.6125.6Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. Michael J SandersonMol Biol Evol200211752195Yes
330222801140.050.825.4microRNA functions. Natascha Bushati, Stephen M CohenAnnu Rev Cell Dev Biol200717506695No
330311401140.025.425.4Next-generation DNA sequencing methods. Elaine R MardisAnnu Rev Genomics Hum Genet200818576944No
330411391139.059.2959.3A "rationalized" arcsine transform. G A StudebakerJ Speech Hear Res19854046587Yes
330522781139.060.2230.1Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. M J Casadaban, S N CohenJ Mol Biol19806997493Yes
330611391139.021.1321.1Regulation of phosphoinositide-specific phospholipase C. S G RheeAnnu Rev Biochem200111395409No
330711391139.035.4335.4Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Ronald A HitesEnviron Sci Technol200414998004Yes
330822771138.553.7426.9ZINC--a free database of commercially available compounds for virtual screening. John J Irwin, Brian K ShoichetJ Chem Inf Model200515667143Yes
330911381138.022.0722.1Structure of chromatin. R D KornbergAnnu Rev Biochem1977332067No
331011381138.031.2631.3Riddle of biofilm resistance. K LewisAntimicrob Agents Chemother200111257008No
331111381138.021.4721.5The power and the promise of DNA methylation markers. Peter W LairdNat Rev Cancer200312671664No
331222761138.00.00.0Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. H H Ussing, K ZerahnActa Physiol Scand195114868510Yes
331322751137.546.5623.3Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. G A Gonzalez, M R MontminyCell19892573431Yes
331468231137.2153.0225.5Principal components analysis corrects for stratification in genome-wide association studies. Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David ReichNat Genet200616862161Yes
331511371137.033.7333.7Unstable angina. A classification. E BraunwaldCirculation19892752565Yes
331634111137.096.4332.1Cytochemical identification of monocytes and granulocytes. L T Yam, C Y Li, W H CrosbyAm J Clin Pathol19715549896Yes
331711371137.049.9550.0How neuroinflammation contributes to neurodegeneration. Richard M RansohoffScience201627540165No
331811361136.056.1456.1The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. G A IlizarovClin Orthop Relat Res19892910611Yes
331922721136.066.7933.4Health effects of fine particulate air pollution: lines that connect. C Arden Pope, Douglas W DockeryJ Air Waste Manag Assoc200616805397No
332034081136.0144.6748.2Principles of nanoparticle design for overcoming biological barriers to drug delivery. Elvin Blanco, Haifa Shen, Mauro FerrariNat Biotechnol201526348965Yes
332134051135.097.0932.4A sensitive and reliable locomotor rating scale for open field testing in rats. D M Basso, M S Beattie, J C BresnahanJ Neurotrauma19957783230Yes
332211351135.020.1520.1Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Eric C LaiNat Genet200211896390Yes
332311351135.021.8721.9VEGF and the quest for tumour angiogenesis factors. Napoleone FerraraNat Rev Cancer200212360282No
332411351135.026.6826.7Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Richard C ScarpullaPhysiol Rev200818391175No
332534051135.0106.6735.6Development and applications of CRISPR-Cas9 for genome engineering. Patrick D Hsu, Eric S Lander, Feng ZhangCell201424906146No
332611341134.030.7630.8A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Ron HardmanEnviron Health Perspect200616451849No
332711341134.027.5127.5Correlates of protection induced by vaccination. Stanley A PlotkinClin Vaccine Immunol201020463105No
332811341134.057.2157.2Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review. Dariush MozaffarianCirculation201626746178No
332911331133.049.749.7Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. S Z LangerBr J Pharmacol197720190No
333022661133.077.3438.7A simple index of Crohn's-disease activity. R F Harvey, J M BradshawLancet19806102236Yes
333111331133.022.1122.1Regulation of transcription by MAP kinase cascades. R TreismanCurr Opin Cell Biol19968791420No
333211331133.044.6544.6Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. Konrad M AndrassyKidney Int201323989362Yes
333367951132.5226.5137.8The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gøtzsche, Jan P VandenbrouckeJ Clin Epidemiol200818313558Yes
333411321132.042.2142.2Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. J T DaugirdasJ Am Soc Nephrol19938305648Yes
333511321132.026.1326.1Allelic discrimination using fluorogenic probes and the 5' nuclease assay. K J LivakGenet Anal199910084106Yes
333611321132.030.7230.7Venous thrombosis: a multicausal disease. F R RosendaalLancet199910209995No
333711321132.023.8923.9Molecular imaging of cancer with positron emission tomography. Sanjiv Sam GambhirNat Rev Cancer200212209157No
333822641132.049.0524.5Deep tissue two-photon microscopy. Fritjof Helmchen, Winfried DenkNat Methods200516299478No
333911321132.00.00.0A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. R D HotchkissArch Biochem194818921848Yes
334011321132.050.3450.3Canadian Diabetes Association 2013 clinical practice guidelines for the prevention and management of diabetes in Canada. Introduction. Alice Y Y ChengCan J Diabetes201324070926No
334111311131.020.2820.3The development of neural stem cells. S TempleNature200111689956No
334211311131.023.1223.1Understanding the odd science of aging. Thomas B L KirkwoodCell200515734677No
334311311131.030.830.8Stronger Brønsted acids. Takahiko AkiyamaChem Rev200717983247Yes
334411301130.028.2428.2Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. I J FidlerCancer Res19901698118Yes
334533901130.072.3124.1A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. M Serrano, G J Hannon, D BeachNature19938259215Yes
334611301130.026.4726.5Aptamers: an emerging class of molecules that rival antibodies in diagnostics. S D JayasenaClin Chem199910471678No
334722601130.044.4422.2Tumour-cell invasion and migration: diversity and escape mechanisms. Peter Friedl, Katarina WolfNat Rev Cancer200312724734No
334811301130.030.5630.6AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. D Grahame HardieGenes Dev201121937710No
334922591129.590.745.4Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococcus species. R Vilgalys, M HesterJ Bacteriol19902376561Yes
335022591129.542.3321.2The druggable genome. Andrew L Hopkins, Colin R GroomNat Rev Drug Discov200212209152No
335111291129.023.5223.5Evolution of ageing. T B KirkwoodNature1977593350Yes
335233871129.090.6330.2Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. R Schreck, P Rieber, P A BaeuerleEMBO J19912065663Yes
335311291129.028.5528.6Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units. C M VenkatachalamBiopolymers19685685102Yes
335411291129.038.2738.3Selective attention and the organization of visual information. J DuncanJ Exp Psychol Gen19846240521Yes
335522581129.058.3829.2Protein oxidation in aging, disease, and oxidative stress. B S Berlett, E R StadtmanJ Biol Chem19979252331No
335611291129.036.0136.0Predictors of postpartum depression: an update. C T BeckNurs Res200111570712Yes
335711291129.030.2130.2Disseminating innovations in health care. Donald M BerwickJAMA200312697800Yes
335833871129.091.2730.4Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Robert G Hart, Lesly A Pearce, Maria I AguilarAnn Intern Med200717577005Yes
335922571128.551.3825.7The Polycomb complex PRC2 and its mark in life. Raphaël Margueron, Danny ReinbergNature201121248841No
336011281128.038.5238.5Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. A R MidgleyEndocrinology19665950482Yes
336111281128.030.2330.2The chromosomal basis of human neoplasia. J J YunisScience19836336310Yes
336211281128.024.7224.7r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock. Michael J SandersonBioinformatics200312538260Yes
336311281128.00.00.0Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. A B StavitskyJ Immunol195413163409Yes
336422561128.020.9110.5A Generalization Of The Retention Index System Including Linear Temperature Programmed Gas-Liquid Partition Chromatography. H Vandendool, P D KratzJ Chromatogr196314062605Yes
336522561128.099.0749.5The lifelong effects of early childhood adversity and toxic stress. Jack P Shonkoff, Andrew S GarnerPediatrics201222201156Yes
336611281128.043.5943.6Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. L SjöströmJ Intern Med201323163728No
336722551127.532.8216.4Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. L M Siegel, K J MontyBiochim Biophys Acta19665329026Yes
336811271127.031.9131.9Cholesterol and the cell membrane. P L YeagleBiochim Biophys Acta19853904832No
336911271127.014.8114.8The nature and significance of platelet products in human plasma. P WolfBr J Haematol19676025241Yes
337011271127.042.5542.5On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. D CollenThromb Haemost19806450468No
337111271127.023.9523.9Fluorescence spectroscopy of single biomolecules. S WeissScience199910073925No
337222541127.068.7634.4Self-management education: history, definition, outcomes, and mechanisms. Kate R Lorig, Halsted HolmanAnn Behav Med200312867348No
337311271127.031.7931.8Neurophysiological and computational principles of cortical rhythms in cognition. Xiao-Jing WangPhysiol Rev201020664082No
337422541127.073.1736.6Long non-coding RNAs: new players in cell differentiation and development. Alessandro Fatica, Irene BozzoniNat Rev Genet201424296535No
3375112691126.9444.4644.4MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space. Fredrik Ronquist, Maxim Teslenko, Paul van der Mark, Daniel L Ayres, Aaron Darling, Sebastian Höhna, Bret Larget, Liang Liu, Marc A Suchard, John P HuelsenbeckSyst Biol201222357727Yes
337622521126.075.4737.7Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. A E Czeizel, I DudásN Engl J Med19921307234Yes
337711261126.023.6323.6Mutator phenotype may be required for multistage carcinogenesis. L A LoebCancer Res19912039987No
337811261126.028.5828.6Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. M M WeiserJ Biol Chem19734698230Yes
337911261126.024.9524.9Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. M KozakNucleic Acids Res19817301588Yes
338022521126.060.4630.2Mechanisms of biofilm resistance to antimicrobial agents. T F Mah, G A O'TooleTrends Microbiol200111166241No
338111261126.020.5920.6DNA methylation in cancer: too much, but also too little. Melanie EhrlichOncogene200212154403No
338222521126.054.1127.1ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Benoît D'Autréaux, Michel B ToledanoNat Rev Mol Cell Biol200717848967No
338311261126.00.00.0Knee joint changes after meniscectomy. T J FairbankJ Bone Joint Surg Br194818894618Yes
338411261126.00.00.0pA, a new scale for the measurement of drug antagonism. H O SchildBr J Pharmacol Chemother194720258355Yes
338511251125.026.5326.5Mechanisms of lipid peroxide formation in animal tissues. E D WillsBiochem J19665964963Yes
338611251125.033.1233.1Cell surface interactions with extracellular materials. K M YamadaAnnu Rev Biochem19836351729No
338722501125.055.0227.5The protective effects of estrogen on the cardiovascular system. M E Mendelsohn, R H KarasN Engl J Med199910362825No
338822501125.053.8826.9Toxoplasmosis. J G Montoya, O LiesenfeldLancet200415194258No
338911251125.042.9242.9Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. George S BloomJAMA Neurol201424493463No
339011251125.045.9445.9The biology and function of exosomes in cancer. Raghu KalluriJ Clin Invest201627035812No
339111241124.067.4667.5Cytoprotection by prostaglandins. A RobertGastroenterology197938173Yes
339211241124.054.4854.5Self-discrepancy: a theory relating self and affect. E T HigginsPsychol Rev19873615707Yes
339311241124.023.0423.0Differentiation and proliferation of hematopoietic stem cells. M OgawaBlood19938499622No
339422481124.059.1329.6Oxidative stress, caloric restriction, and aging. R S Sohal, R WeindruchScience19968658196No
339511241124.00.00.0The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. J VagueAm J Clin Nutr195613282851Yes
339611241124.017.2517.2Inherited Antithrombin Deficiency Causing Thrombophilia. O EgebergThromb Diath Haemorrh196514347873Yes
339722481124.049.0224.5Regeneration beyond the glial scar. Jerry Silver, Jared H MillerNat Rev Neurosci200414735117No
339822481124.068.4134.2Mitochondrial fission, fusion, and stress. Richard J Youle, Alexander M van der BliekScience201222936770No
339911231123.023.4423.4ALSCRIPT: a tool to format multiple sequence alignments. G J BartonProtein Eng19938433969Yes
340011231123.025.4225.4The columnar organization of the neocortex. V B MountcastleBrain19979153131No
340122461123.088.5544.3Statistical methods for assessing measurement error (reliability) in variables relevant to sports medicine. G Atkinson, A M NevillSports Med19989820922No
340211231123.045.9546.0The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. Natalie A de MortonAust J Physiother200919463084Yes
340311231123.070.8370.8Information bias in health research: definition, pitfalls, and adjustment methods. Alaa AlthubaitiJ Multidiscip Healthc201627217764No
340444891122.2103.2825.8SCOP: a structural classification of proteins database for the investigation of sequences and structures. A G Murzin, S E Brenner, T Hubbard, C ChothiaJ Mol Biol19957723011Yes
340511221122.027.727.7Formation and function of the myofibroblast during tissue repair. Boris HinzJ Invest Dermatol200717299435No
340622441122.050.0325.0Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. William G Kaelin, Peter J RatcliffeMol Cell200818498744No
340711221122.064.3264.3Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV. Douglas A DrossmanGastroenterology201627144617Yes
340844861121.5110.1927.5Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod MenonProc Natl Acad Sci U S A200312506194Yes
340922431121.550.9725.5Next-generation DNA sequencing. Jay Shendure, Hanlee JiNat Biotechnol200818846087Yes
341011211121.022.0522.1Cytokine receptor signalling. J N IhleNature19957566171No
341111211121.032.6232.6Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. P S ToftsJ Magn Reson Imaging19979039598No
341211211121.029.5929.6Time is brain--quantified. Jeffrey L SaverStroke200616339467Yes
341322411120.559.1629.6Fitness effects on the cognitive function of older adults: a meta-analytic study. Stanley Colcombe, Arthur F KramerPsychol Sci200312661673Yes
341411201120.034.4534.5Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J E OesterlingJ Urol19911707989No
341522401120.048.9124.5Prediction of protein secondary structure at better than 70% accuracy. B Rost, C SanderJ Mol Biol19938345525Yes
341622401120.051.1225.6Modes of resistance to anti-angiogenic therapy. Gabriele Bergers, Douglas HanahanNat Rev Cancer200818650835No
341722401120.064.5132.3Strategies in the design of nanoparticles for therapeutic applications. Robby A Petros, Joseph M DeSimoneNat Rev Drug Discov201020616808No
341844761119.0145.0736.3The cholinergic hypothesis of geriatric memory dysfunction. R T Bartus, R L Dean, B Beer, A S LippaScience19827046051No
341922371118.550.1525.1Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. P van den Driessche, James WatmoughMath Biosci200212387915Yes
342011181118.051.5151.5Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder. M RutterBr J Psychiatry19853830321Yes
342111181118.00.00.0Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins. R D OwenScience194517755278Yes
342211181118.057.0157.0Patient reported outcome measures could help transform healthcare. Nick BlackBMJ201323358487Yes
342344701117.5107.8727.0C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. P M Ridker, C H Hennekens, J E Buring, N RifaiN Engl J Med200010733371Yes
342455861117.2110.8722.2Electrostatics of nanosystems: application to microtubules and the ribosome. N A Baker, D Sept, S Joseph, M J Holst, J A McCammonProc Natl Acad Sci U S A200111517324Yes
342511171117.023.5223.5Molecular cloning and expression of glycogen synthase kinase-3/factor A. J R WoodgettEMBO J19902164470Yes
342611171117.051.4751.5Analysis of Fickian and non-Fickian drug release from polymers. N A PeppasPharm Acta Helv19854011621Yes
342733501116.7119.3939.8Neighborhoods and violent crime: a multilevel study of collective efficacy. R J Sampson, S W Raudenbush, F EarlsScience19979252316Yes
342866991116.5153.425.6Staging of brain pathology related to sporadic Parkinson's disease. Heiko Braak, Kelly Del Tredici, Udo Rüb, Rob A I de Vos, Ernst N H Jansen Steur, Eva BraakNeurobiol Aging200312498954Yes
342911161116.023.8123.8Complement. Second of two parts. M J WalportN Engl J Med200111297706No
343022311115.545.1622.6A survey of telomerase activity in human cancer. J W Shay, S BacchettiEur J Cancer19979282118No
343122311115.572.9536.5Microdroplet Assay Of Human Serum Cytotoxins. P I Terasaki, J D McclellandNature196414248725Yes
343233461115.389.2729.8A nonparametric method for automatic correction of intensity nonuniformity in MRI data. J G Sled, A P Zijdenbos, A C EvansIEEE Trans Med Imaging19989617910Yes
343311151115.036.9637.0Chemoprevention of cancer. L W WattenbergCancer Res19853880665No
343411151115.026.5426.5Molecular drive: a cohesive mode of species evolution. G DoverNature19827110332Yes
343511151115.025.6325.6Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis. M M TirionPhys Rev Lett199610063201Yes
343611151115.025.2725.3The impact of next-generation sequencing technology on genetics. Elaine R MardisTrends Genet200818262675No
343722291114.569.8834.9Excitatory amino acid transmitters. J C Watkins, R H EvansAnnu Rev Pharmacol Toxicol19816112965No
343822291114.549.6424.8Obesity and insulin resistance. B B Kahn, J S FlierJ Clin Invest200010953022No
343922291114.560.8130.4Mechanisms of mitophagy. Richard J Youle, Derek P NarendraNat Rev Mol Cell Biol201121179058No
344011141114.034.6634.7Protein damage and degradation by oxygen radicals. I. general aspects. K J DaviesJ Biol Chem19873036875Yes
344122281114.050.1125.1Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. R J Britten, D E KohneScience19684874239Yes
344211141114.031.4531.4Studies on histones. 7. Preparative methods for histone fractions from calf thymus. E W JohnsBiochem J19645840387Yes
344311141114.020.6420.6The ubiquitin-proteasome pathway: on protein death and cell life. A CiechanoverEMBO J19989857172No
344411141114.027.7327.7Immortal time bias in pharmaco-epidemiology. Samy SuissaAm J Epidemiol200818056625No
344522271113.534.4517.2Construction of phylogenetic trees. W M Fitch, E MargoliashScience19675334057No
344611131113.028.4728.5Linkage strategies for genetically complex traits. I. Multilocus models. N RischAm J Hum Genet19902301392Yes
344711131113.028.0328.0Sex-hormone-binding globulin. D C AndersonClin Endocrinol (Oxf)19744134992No
344811131113.019.8719.9NFAT proteins: key regulators of T-cell development and function. Fernando MacianNat Rev Immunol200515928679No
344911131113.035.7135.7Social support and health: a review of physiological processes potentially underlying links to disease outcomes. Bert N UchinoJ Behav Med200616758315No
3450111291112.9253.3725.3Scalable molecular dynamics with NAMD. James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kalé, Klaus SchultenJ Comput Chem200516222654Yes
345111121112.039.3539.4Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. J N WasserheitSex Transm Dis19921595015No
345222241112.059.029.5Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. R A Ignotz, J MassaguéJ Biol Chem19863456347Yes
345322241112.044.8322.4RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. M B Shapiro, P SenapathyNucleic Acids Res19873658675Yes
345411121112.029.3429.3Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. S IrwinPsychopharmacologia19685679627Yes
345511121112.032.9232.9Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. M J GassonJ Bacteriol19836403500Yes
345611121112.037.4437.4A review of psychological risk factors in back and neck pain. S J LintonSpine (Phila Pa 1976)200010788861No
345744481112.0116.929.2Prevalence and trends in obesity among US adults, 1999-2000. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L JohnsonJAMA200212365955Yes
345811121112.00.00.0A cytoarchitectonic atlas of the spinal cord in the cat. B RexedJ Comp Neurol195413163236Yes
345922241112.00.00.0Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. A H Coons, M H KaplanJ Exp Med195015395569Yes
346011121112.026.1926.2Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. Christopher Paul WildCancer Epidemiol Biomarkers Prev200516103423No
346111121112.00.00.0The Stability of Broken Ends of Chromosomes in Zea Mays. B McClintockGenetics194117247004Yes
346222241112.063.2831.6Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Patrick S Ward, Craig B ThompsonCancer Cell201222439925No
346311111111.031.8731.9The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. S Nolen-HoeksemaJ Abnorm Psychol200011016119Yes
346411111111.025.7725.8Anatomy and regulation of the central melanocortin system. Roger D ConeNat Neurosci200515856065No
346511111111.025.2125.2Viruses in the sea. Curtis A SuttleNature200516163346No
346611111111.00.00.0Comparing individual means in the analysis of variance. J W TukeyBiometrics194918151955Yes
346766661111.0252.1542.0Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Laura J Damschroder, David C Aron, Rosalind E Keith, Susan R Kirsh, Jeffery A Alexander, Julie C LoweryImplement Sci200919664226Yes
346833321110.780.7526.9Mechanisms linking obesity to insulin resistance and type 2 diabetes. Steven E Kahn, Rebecca L Hull, Kristina M UtzschneiderNature200617167471No
346922211110.545.5922.8Genomic control for association studies. B Devlin, K RoederBiometrics199911315092Yes
347011101110.030.8330.8On the utility of P3 amplitude as a measure of processing capacity. A KokPsychophysiology200111352145No
347122191109.554.0927.0Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Herbert Tilg, Alexander R MoschenNat Rev Immunol200616998510No
347244371109.224.266.1The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. P J Randle, P B Garland, C N Hales, E A NewsholmeLancet196313990765Yes
347333271109.0113.6437.9Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. M Hamberg, J Svensson, B SamuelssonProc Natl Acad Sci U S A19751059088Yes
347422181109.051.9926.0Cellular uptake of the tat protein from human immunodeficiency virus. A D Frankel, C O PaboCell19882849510Yes
347511091109.024.5624.6The molecular biology of leukocyte chemoattractant receptors. P M MurphyAnnu Rev Immunol19948011292No
347611091109.033.6633.7Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. P J BasserNMR Biomed19958739270No
347722161108.071.4235.7Wine, alcohol, platelets, and the French paradox for coronary heart disease. S Renaud, M de LorgerilLancet19921351198Yes
347822161108.090.5645.3Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. L A Clark, D WatsonJ Abnorm Psychol19911918611No
347911081108.024.1524.1Toward self-organization and complex matter. Jean-Marie LehnScience200211923524Yes
348011081108.021.0621.1Focal adhesion kinase: the first ten years. J Thomas ParsonsJ Cell Sci200312640026No
348111081108.044.1644.2Myeloid-Derived Suppressor Cells. Dmitry I GabrilovichCancer Immunol Res201728052991No
348222151107.547.4523.7Roles of CHOP/GADD153 in endoplasmic reticulum stress. S Oyadomari, M MoriCell Death Differ200414685163No
348311071107.027.3527.4Avidin. N M GreenAdv Protein Chem1975237414Yes
348411071107.022.2822.3Primary response genes induced by growth factors and tumor promoters. H R HerschmanAnnu Rev Biochem19911883198No
348511071107.026.1726.2Cells in stress: transcriptional activation of heat shock genes. R I MorimotoScience19938451637No
348622141107.059.9930.0Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J A Sterne, M EggerJ Clin Epidemiol200111576817Yes
348711071107.026.1126.1Differential projections of the infralimbic and prelimbic cortex in the rat. Robert P VertesSynapse200414579424Yes
348855311106.2234.0546.8Integrating single-cell transcriptomic data across different conditions, technologies, and species. Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi, Rahul SatijaNat Biotechnol201829608179Yes
348911061106.023.2723.3A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. J MilbrandtScience19873672127Yes
349022121106.049.3124.7Synaptic activity and the construction of cortical circuits. L C Katz, C J ShatzScience19968895456No
349111061106.040.1840.2Relativistic electronic-structure calculations employing a two-component no-pair formalism with external-field projection operators. B A HessPhys Rev A Gen Phys19869897114Yes
349211061106.026.3626.4Quantification of beta-sheet amyloid fibril structures with thioflavin T. H LeVineMethods Enzymol199910507030Yes
349311061106.029.0229.0Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. F P GuengerichChem Res Toxicol200111409933No
349411061106.023.623.6VEGF as a key mediator of angiogenesis in cancer. Peter CarmelietOncology200516301830No
349522111105.570.7635.4Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Thomas A Wynn, Thirumalai R RamalingamNat Med201222772564No
349633161105.366.0322.0SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. Jay D Horton, Joseph L Goldstein, Michael S BrownJ Clin Invest200211994399No
349711051105.027.1727.2The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion. S RosemanChem Phys Lipids19705476326Yes
349811051105.024.4424.4Lithium batteries and cathode materials. M Stanley WhittinghamChem Rev200415669156Yes
349933141104.791.8530.6Spirometric reference values from a sample of the general U.S. population. J L Hankinson, J R Odencrantz, K B FedanAm J Respir Crit Care Med19999872837Yes
350022091104.582.341.1Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. I B Wilson, P D ClearyJAMA19957996652Yes
350111041104.021.3121.3Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. A S BaldwinJ Clin Invest200111160144No
350211041104.032.6832.7Cognitive and affective development in adolescence. Laurence SteinbergTrends Cogn Sci200515668099No
350311041104.022.0322.0Models, mechanisms and clinical evidence for cancer dormancy. Julio A Aguirre-GhisoNat Rev Cancer200717957189No
350422071103.50.00.0Cortisone in ulcerative colitis; final report on a therapeutic trial. S C Truelove, L J WittsBr Med J195513260656Yes
350522071103.552.6626.3Reducing the dimensionality of data with neural networks. G E Hinton, R R SalakhutdinovScience200616873662Yes
350622071103.565.2732.6Chronic hepatitis B: update 2009. Anna S F Lok, Brian J McMahonHepatology200919714720Yes
350722071103.567.1533.6Reactive oxygen species, cellular redox systems, and apoptosis. Magdalena L Circu, Tak Yee AwFree Radic Biol Med201020045723No
350822061103.027.6913.8Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques. P Gold, S O FreedmanJ Exp Med196514270243Yes
350911031103.025.725.7Solid-state nanopores. Cees DekkerNat Nanotechnol200718654264No
351033081102.794.5931.5Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Geoffrey R Norman, Jeff A Sloan, Kathleen W WyrwichMed Care200312719681No
351122051102.558.129.1Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. I Chopra, M RobertsMicrobiol Mol Biol Rev200111381101Yes
351266141102.3173.0128.8Prediction of coronary heart disease using risk factor categories. P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B KannelCirculation19989603539Yes
351311021102.029.9730.0Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. S G JohnsenHormones19705527187Yes
351411021102.042.3842.4The role of endothelium in the responses of vascular smooth muscle to drugs. R F FurchgottAnnu Rev Pharmacol Toxicol19846203480No
351511021102.027.3527.4The Trk family of neurotrophin receptors. M BarbacidJ Neurobiol19947852993No
351644081102.0148.9237.2Prevalence and trends in obesity among US adults, 1999-2008. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R CurtinJAMA201020071471Yes
351711021102.037.5237.5Globalization of diabetes: the role of diet, lifestyle, and genes. Frank B HuDiabetes Care201121617109No
351822031101.549.8624.9A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. J N Cohn, G TognoniN Engl J Med200111759645Yes
351911011101.039.6339.6Methods for dealing with reaction time outliers. R RatcliffPsychol Bull19938272468Yes
352011011101.028.1828.2Neuropathology of Parkinson's disease. L S FornoJ Neuropathol Exp Neurol19968786384No
352111011101.024.624.6Current concepts of the pathogenesis of the acute coronary syndromes. P LibbyCirculation200111457759No
352222021101.063.5631.8Relaxing the rule of ten events per variable in logistic and Cox regression. Eric Vittinghoff, Charles E McCullochAm J Epidemiol200717182981Yes
352322021101.050.9325.5The host defense of Drosophila melanogaster. Bruno Lemaitre, Jules HoffmannAnnu Rev Immunol200717201680No
352411011101.00.00.0Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent. D L MorrisScience194817814729Yes
352522011100.538.2719.1A synthetic oscillatory network of transcriptional regulators. M B Elowitz, S LeiblerNature200010659856Yes
352611001100.050.9951.0Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Y KonoArch Biochem Biophys197824422Yes
352711001100.023.0223.0T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. R H SchwartzAnnu Rev Immunol19852415139No
352811001100.029.9229.9Aging, energy, and oxidative stress in neurodegenerative diseases. M F BealAnn Neurol19957668820No
352911001100.022.4122.4Osmotic stress signaling and osmoadaptation in yeasts. Stefan HohmannMicrobiol Mol Biol Rev200212040128No
353011001100.022.8222.8Membrane recognition by phospholipid-binding domains. Mark A LemmonNat Rev Mol Cell Biol200818216767No
353121991099.563.5231.8The acute phase response. H Baumann, J GauldieImmunol Today19947512342No
353221981099.051.7825.9T antigen is bound to a host protein in SV40-transformed cells. D P Lane, L V CrawfordNature1979218111Yes
353310991099.033.3933.4Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. D L ColemanDiabetologia1978350680No
353421981099.049.0724.5Cell cycle control and cancer. L H Hartwell, M B KastanScience19947997877No
353510991099.022.9823.0Phenotypic plasticity and the epigenetics of human disease. Andrew P FeinbergNature200717522677No
353610991099.039.8739.9Visual attention: the past 25 years. Marisa CarrascoVision Res201121549742No
353721971098.585.8342.9Long Noncoding RNAs in Cancer Pathways. Adam M Schmitt, Howard Y ChangCancer Cell201627070700No
353810981098.019.6419.6Time-dependent processes in memory storage. J L McGaughScience19665917768Yes
353921961098.045.4522.7p53: puzzle and paradigm. L J Ko, C PrivesGenes Dev19968654922No
354010981098.036.0936.1Socioeconomic disadvantage and child development. V C McLoydAm Psychol19989491747No
354110981098.00.00.0Cleavage of the haem-protein link by acid methylethylketone. F W TealeBiochim Biophys Acta195913837237Yes
354210981098.045.1445.1How does sexual minority stigma "get under the skin"? A psychological mediation framework. Mark L HatzenbuehlerPsychol Bull200919702379No
354376841097.7239.0434.1Toxicity and response criteria of the Eastern Cooperative Oncology Group. M M Oken, R H Creech, D C Tormey, J Horton, T E Davis, E T McFadden, P P CarboneAm J Clin Oncol19827165009Yes
354421951097.570.2535.1Central sensitization: a generator of pain hypersensitivity by central neural plasticity. Alban Latremoliere, Clifford J WoolfJ Pain200919712899No
354521951097.594.9847.5Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. Peter C Austin, Elizabeth A StuartStat Med201526238958No
354610971097.018.8518.9Cell lines derived from late embryonic stages of Drosophila melanogaster. I SchneiderJ Embryol Exp Morphol19724625067Yes
354765821097.0142.9323.8Obesity is associated with macrophage accumulation in adipose tissue. Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W FerranteJ Clin Invest200314679176Yes
354810971097.024.2124.2Personal genomes: The case of the missing heritability. Brendan MaherNature200818987709No
354910971097.028.1928.2Ovarian cancer development and metastasis. Ernst LengyelAm J Pathol201020651229Yes
355010961096.055.0655.1Osseointegration and its experimental background. P I BrånemarkJ Prosthet Dent19836352924No
355110961096.020.2620.3Chronic myeloid leukemia. C L SawyersN Engl J Med199910219069No
355210961096.027.3427.3Pathogenesis of osteoporosis: concepts, conflicts, and prospects. Lawrence G RaiszJ Clin Invest200516322775No
355332881096.0585.12195.0MEGA11: Molecular Evolutionary Genetics Analysis Version 11. Koichiro Tamura, Glen Stecher, Sudhir KumarMol Biol Evol202133892491Yes
355421911095.565.632.82,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. A Poland, J C KnutsonAnnu Rev Pharmacol Toxicol19826282188No
355521911095.557.828.9Localized surface plasmon resonance spectroscopy and sensing. Katherine A Willets, Richard P Van DuyneAnnu Rev Phys Chem200717067281No
355610951095.018.9819.0Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. R RothsteinMethods Enzymol19912005793Yes
355710951095.020.7520.8Luciferase reporter gene vectors for analysis of promoters and enhancers. S K NordeenBiotechniques19882908509Yes
355810951095.00.00.0Motivation reconsidered: the concept of competence. R W WhitePsychol Rev195913844397Yes
355910951095.00.00.0The purine and pyrimidine composition of deoxypentose nucleic acids. G R WyattBiochem J195114838906Yes
356010951095.032.8132.8Social support and patient adherence to medical treatment: a meta-analysis. M Robin DiMatteoHealth Psychol200415008666Yes
356132851095.076.0825.4Obesity induces a phenotypic switch in adipose tissue macrophage polarization. Carey N Lumeng, Jennifer L Bodzin, Alan R SaltielJ Clin Invest200717200717Yes
356221891094.545.7922.9The Hsp70 and Hsp60 chaperone machines. B Bukau, A L HorwichCell19989476895No
356321891094.553.826.9Quorum sensing: cell-to-cell communication in bacteria. Christopher M Waters, Bonnie L BasslerAnnu Rev Cell Dev Biol200516212498No
356410941094.027.727.7Two distinct classes of carbohydrate-recognition domains in animal lectins. K DrickamerJ Biol Chem19883290208No
356521881094.077.6238.8Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. A I Basbaum, H L FieldsAnnu Rev Neurosci19846143527No
356610941094.022.4122.4mRNA stability in mammalian cells. J RossMicrobiol Rev19957565413No
356710941094.027.9928.0Glutathione and its role in cellular functions. H SiesFree Radic Biol Med199910569624No
356832821094.0101.6233.9PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. J W Varni, M Seid, P S KurtinMed Care200111468499Yes
356910941094.027.0527.1Seed Germination and Dormancy. J. D. BewleyPlant Cell199712237375Yes
357021871093.50.00.0Micromethod for the direct determination of serum triglycerides. E Van Handel, D B ZilversmitJ Lab Clin Med195713439279Yes
357110931093.032.6332.6Tests for emotionality in rats and mice: a review. J ArcherAnim Behav19734578750No
357210931093.032.3132.3Spatially heterogeneous dynamics in supercooled liquids. M D EdigerAnnu Rev Phys Chem200011031277Yes
357310931093.025.0425.0The prefrontal cortex--an update: time is of the essence. J M FusterNeuron200111394996No
357410931093.046.4346.4CONSORT-EHEALTH: improving and standardizing evaluation reports of Web-based and mobile health interventions. Gunther EysenbachJ Med Internet Res201122209829No
357510921092.038.4938.5Spin trapping: ESR parameters of spin adducts. G R BuettnerFree Radic Biol Med19872826304No
357610921092.042.9643.0Corticosteroids and lymphoid cells. H N ClamanN Engl J Med19725043524Yes
357710921092.033.9834.0The oxidation hypothesis of atherosclerosis. J L WitztumLancet19947916078No
357854601092.0114.9823.0The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. J W Harper, G R Adami, N Wei, K Keyomarsi, S J ElledgeCell19938242751Yes
357910921092.025.2525.2P-450 metabolites of arachidonic acid in the control of cardiovascular function. Richard J RomanPhysiol Rev200211773611No
358021841092.074.5437.3The complexity of NF-κB signaling in inflammation and cancer. Bastian Hoesel, Johannes A SchmidMol Cancer201323915189No
358132741091.398.0932.7Depression: a new animal model sensitive to antidepressant treatments. R D Porsolt, M Le Pichon, M JalfreNature1977559941Yes
358210911091.027.6427.6Selectins: interpreters of cell-specific carbohydrate information during inflammation. L A LaskyScience19921439808No
358310911091.029.2429.2A kinetic photometric method for serum gamma-glutamyl transpeptidase. G SzaszClin Chem19695773262Yes
358421811090.5105.0652.5Functional Classification and Experimental Dissection of Long Noncoding RNAs. Florian Kopp, Joshua T MendellCell201829373828No
358510901090.019.7519.8Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. R A FryeBiochem Biophys Res Commun200010873683Yes
358610901090.025.9325.9Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. Thomas A WynnJ Clin Invest200717332879No
358721791089.568.7734.4Glutamate and the pathophysiology of hypoxic--ischemic brain damage. S M Rothman, J W OlneyAnn Neurol19862421636No
358821791089.549.9525.0Hepatitis C virus infection. G M Lauer, B D WalkerN Engl J Med200111439948No
358921791089.547.9724.0Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. Daniel J Hicklin, Lee M EllisJ Clin Oncol200515585754No
359032681089.3177.2159.1Hepatocellular carcinoma. Alejandro Forner, María Reig, Jordi BruixLancet201829307467No
359121781089.043.6621.8Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. P E Wright, H J DysonJ Mol Biol199910550212No
359210891089.00.00.0Aniline hydrogen phthalate as a spraying reagent for chromatography of sugars. S M PartridgeNature194918140444Yes
359354441088.8164.1232.8Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. Salim Yusuf, Bertram Pitt, Clarence E Davis, William B Hood, Jay N CohnN Engl J Med19912057034Yes
359421771088.564.2332.1Are the dorsal and ventral hippocampus functionally distinct structures? Michael S Fanselow, Hong-Wei DongNeuron201020152109No
359521761088.081.8140.9Understanding face recognition. V Bruce, A YoungBr J Psychol19863756376Yes
359610881088.024.6324.6Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system. T IkemuraJ Mol Biol19816175758Yes
359721761088.074.337.1Consensus methods for medical and health services research. J Jones, D HunterBMJ19957640549No
359810881088.07.827.8Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. R M BerneAm J Physiol196313971060Yes
359910881088.025.4925.5Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures. Frank WürthnerChem Commun (Camb)200415263926Yes
360010881088.023.3623.4Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. Michael ForgacNat Rev Mol Cell Biol200717912264No
360165271087.8159.3526.6Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. S Yusuf, P Sleight, J Pogue, J Bosch, R Davies, G DagenaisN Engl J Med200010639539Yes
360210871087.042.4842.5A simple method for determination of serum catalase activity and revision of reference range. L GóthClin Chim Acta19912029780Yes
360310871087.027.5927.6Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. M J BerridgeBiochem J19836309155Yes
360410871087.022.9823.0Twilight zone of protein sequence alignments. B RostProtein Eng199910195279Yes
360510871087.00.00.0Asymptomatic infections of the urinary tract. E H KassTrans Assoc Am Physicians195613380946Yes
360621731086.579.9740.0The Modified Mini-Mental State (3MS) examination. E L Teng, H C ChuiJ Clin Psychiatry19873611032Yes
360710861086.055.0255.0The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. J A KoufmanLaryngoscope19911895864No
360810861086.030.8430.8Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. T FeiziNature19852579340Yes
360921721086.050.9625.5Peroxidase-labeled antibody. A new method of conjugation. P K Nakane, A KawaoiJ Histochem Cytochem19744443551Yes
361010861086.025.1325.1Selectins and their ligands: current concepts and controversies. G S KansasBlood19968896391No
361110861086.023.8923.9Molecular mechanisms of myocardial remodeling. B SwynghedauwPhysiol Rev19999922372No
361210861086.029.8329.8Cholinesterase inhibitors for Alzheimer's disease. J BirksCochrane Database Syst Rev200616437532No
361310861086.046.2546.2A comprehensive review on metabolic syndrome. Jaspinder KaurCardiol Res Pract201424711954No
361421711085.50.00.0A revision of the Schoenheimer-Sperry method for cholesterol determination. W M Sperry, M WebbJ Biol Chem195014794694Yes
361554261085.2302.4160.5ModelFinder: fast model selection for accurate phylogenetic estimates. Subha Kalyaanamoorthy, Bui Quang Minh, Thomas K F Wong, Arndt von Haeseler, Lars S JermiinNat Methods201728481363Yes
361610851085.037.2937.3Multiple organ failure. Pathophysiology and potential future therapy. E A DeitchAnn Surg19921503516No
361710851085.020.5920.6At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. M KozakJ Mol Biol19873681984Yes
361810851085.023.7523.8New ideas about atrial fibrillation 50 years on. Stanley NattelNature200211805846No
361910851085.00.00.0The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs. M VogtJ Physiol195413152692Yes
362021701085.060.7230.4Burden of major musculoskeletal conditions. Anthony D Woolf, Bruce PflegerBull World Health Organ200314710506No
362165071084.5167.5627.9The capsaicin receptor: a heat-activated ion channel in the pain pathway. M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D JuliusNature19979349813Yes
362221681084.081.6640.8Visual search and stimulus similarity. J Duncan, G W HumphreysPsychol Rev19892756067Yes
362310841084.026.5626.6DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. J F WardProg Nucleic Acid Res Mol Biol19883065826No
362410841084.023.323.3PHD: predicting one-dimensional protein structure by profile-based neural networks. B RostMethods Enzymol19968743704Yes
362510841084.020.3120.3Progress in human tumour immunology and immunotherapy. S A RosenbergNature200111357146No
362610831083.041.6841.7A new international staging system for lung cancer. C F MountainChest19863514171No
362710831083.032.4832.5A teacher rating scale for use in drug studies with children. C K ConnersAm J Psychiatry19694900822Yes
362821661083.047.223.6Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. T Hunter, J PinesCell19947954824No
362910831083.030.4630.5Limbic-cortical dysregulation: a proposed model of depression. H S MaybergJ Neuropsychiatry Clin Neurosci19979276848No
363021651082.566.9233.5Mental rotation of three-dimensional objects. R N Shepard, J MetzlerScience19715540314Yes
363121641082.064.9732.5A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. J J Sedmak, S E GrossbergAnal Biochem197768686Yes
363210821082.025.1525.1BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data. O GascuelMol Biol Evol19979254330Yes
363321631081.563.4331.7Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. J M Reul, E R de KloetEndocrinology19852998738Yes
363410811081.032.7732.8Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. P StastnyN Engl J Med1978147420Yes
363510811081.058.0358.0The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement. M M PanjabiJ Spinal Disord19921490034Yes
363610811081.020.7220.7Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities. F FonnumBiochem J19694982085Yes
363721621081.082.6741.3The Posttraumatic Growth Inventory: measuring the positive legacy of trauma. R G Tedeschi, L G CalhounJ Trauma Stress19968827649Yes
363810811081.00.00.0The stereotaxic method and radiosurgery of the brain. L LeksellActa Chir Scand195114914373Yes
363910811081.028.5628.6Abiotic stress, the field environment and stress combination. Ron MittlerTrends Plant Sci200616359910No
364021621081.0154.0377.0OrthoFinder: phylogenetic orthology inference for comparative genomics. David M Emms, Steven KellyGenome Biol201931727128Yes
364132421080.784.6728.2Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. M K Parmar, V Torri, L StewartStat Med19989921604Yes
364221611080.545.1422.6Mitogen-activated protein kinase pathways. M J Robinson, M H CobbCurr Opin Cell Biol19979069255No
364321611080.560.630.3ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control. Graham Noctor, Christine H. FoyerAnnu Rev Plant Physiol Plant Mol Biol199815012235Yes
364421611080.575.9238.0A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. Walter J Paulus, Carsten TschöpeJ Am Coll Cardiol201323684677No
364543211080.2207.0151.8Genome sequence-based species delimitation with confidence intervals and improved distance functions. Jan P Meier-Kolthoff, Alexander F Auch, Hans-Peter Klenk, Markus GökerBMC Bioinformatics201323432962Yes
364610801080.061.6961.7The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture. J CasselAm J Epidemiol1976782233No
364710801080.030.2130.2Transport of molecules in the tumor interstitium: a review. R K JainCancer Res19873555767No
364810801080.021.3821.4Coiled coils: new structures and new functions. A LupasTrends Biochem Sci19968918191No
364910801080.029.1529.1What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. Michael A BabyakPsychosom Med200415184705Yes
365010801080.021.4121.4Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution. Mats G L GustafssonProc Natl Acad Sci U S A200516141335Yes
365110801080.020.7820.8mTOR and cancer: insights into a complex relationship. David M SabatiniNat Rev Cancer200616915295No
365210791079.021.3821.4Protein denaturation. C. Theoretical models for the mechanism of denaturation. C TanfordAdv Protein Chem19704912353No
365310791079.022.3422.3Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. Z YangMol Biol Evol19989580986Yes
365410791079.00.00.0The effect of emotion on cue utilization and the organization of behavior. J A EasterbrookPsychol Rev195913658305Yes
365510791079.08.278.3The Permeability Of Capillaries In Various Organs As Determined By Use Of The 'Indicator Diffusion' Method. C CroneActa Physiol Scand196314078649Yes
365610791079.039.6639.7The pathobiology of vascular dementia. Costantino IadecolaNeuron201324267647No
365732361078.7115.3938.5Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. P S Walsh, D A Metzger, R HiguchiBiotechniques19911867860Yes
365864721078.7138.9723.2Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. D A Melton, P A Krieg, M R Rebagliati, T Maniatis, K Zinn, M R GreenNucleic Acids Res19846091052Yes
365910781078.056.3256.3The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. G A IlizarovClin Orthop Relat Res19892912628Yes
366010781078.018.8318.8Regulatory T cells in autoimmmunity*. E M ShevachAnnu Rev Immunol200010837065No
366110781078.018.3118.3Molecular mechanisms of axon guidance. Barry J DicksonScience200212471249No
366210781078.025.8525.9ImageJ for microscopy. Tony J CollinsBiotechniques200717936939No
366310781078.033.5933.6Lanthanide luminescence for biomedical analyses and imaging. Jean-Claude G BünzliChem Rev201020151630No
366443111077.8157.2539.3Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. K F Schulz, I Chalmers, R J Hayes, D G AltmanJAMA19957823387Yes
366521541077.043.5321.8In search of the 'missing self': MHC molecules and NK cell recognition. H G Ljunggren, K KärreImmunol Today19902201309No
366610771077.025.3925.4Nitric oxide, oxidants, and protein tyrosine nitration. Rafael RadiProc Natl Acad Sci U S A200415020765Yes
366710771077.027.0927.1Fibrinogen and fibrin structure and functions. M W MosessonJ Thromb Haemost200516102057No
366821541077.065.6532.8Ischemia and reperfusion--from mechanism to translation. Holger K Eltzschig, Tobias EckleNat Med201122064429No
366910771077.038.0638.1Epidemiology of heart failure. Véronique L RogerCirc Res201323989710No
367021531076.596.4448.2Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. J B Mulliken, J GlowackiPlast Reconstr Surg19827063565Yes
367121521076.074.6337.3A formula to estimate the approximate surface area if height and weight be known. 1916. D Du Bois, E F Du BoisNutrition19892520314No
367210761076.024.8324.8Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. E M TanAdv Immunol19892646863No
367310761076.016.016.0The moulding of senescence by natural selection. W D HamiltonJ Theor Biol19666015424Yes
367410761076.036.0336.0Lipid peroxidation and antioxidants as biomarkers of tissue damage. J M GutteridgeClin Chem19957497639No
367510761076.035.8335.8Why we need observational studies to evaluate the effectiveness of health care. N BlackBMJ19968634569Yes
367621511075.539.6919.8AP-1 as a regulator of cell life and death. Eitan Shaulian, Michael KarinNat Cell Biol200211988758No
367721511075.541.8620.9STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Hiroki Ishikawa, Glen N BarberNature200818724357Yes
367810751075.031.2331.2Why people use health services. I M RosenstockMilbank Mem Fund Q19665967464Yes
367910751075.037.8237.8Coronary physiology. E O FeiglPhysiol Rev19836296890No
368010751075.040.240.2Beyond curriculum reform: confronting medicine's hidden curriculum. F W HaffertyAcad Med19989580717Yes
368121501075.046.2223.1Finding and evaluating community structure in networks. M E J Newman, M GirvanPhys Rev E Stat Nonlin Soft Matter Phys200414995526Yes
368221501075.061.1230.6Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. Ivan Sondi, Branka Salopek-SondiJ Colloid Interface Sci200415158396Yes
368310751075.072.8172.8Non-alcoholic fatty liver disease - A global public health perspective. Zobair M YounossiJ Hepatol201930414863No
368421501075.0247.54123.8Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. David J Newman, Gordon M CraggJ Nat Prod202032162523No
368532231074.3127.2442.4Concurrent and predictive validity of a self-reported measure of medication adherence. D E Morisky, L W Green, D M LevineMed Care19863945130Yes
368610741074.027.427.4Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. J P TamProc Natl Acad Sci U S A19883399498Yes
368710741074.028.6728.7Statistical quality control and routine data processing for radioimmunoassays and immunoradiometric assays. D RodbardClin Chem19744370388No
368810741074.028.3228.3Microtubule formation in vitro in solutions containing low calcium concentrations. R C WeisenbergScience19724626639Yes
368910741074.028.4328.4Invited review: Aging and sarcopenia. Timothy J DohertyJ Appl Physiol (1985)200312970377No
369010741074.030.0330.0The locus coeruleus and noradrenergic modulation of cognition. Susan J SaraNat Rev Neurosci200919190638No
369132211073.763.0521.0Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Paola Scaffidi, Tom Misteli, Marco E BianchiNature200212110890Yes
369221471073.583.5641.8Glutathione reductase. I Carlberg, B MannervikMethods Enzymol19853003504Yes
369321471073.583.2841.6Chronic catheterization of the spinal subarachnoid space. T L Yaksh, T A RudyPhysiol Behav197614677603Yes
369410731073.041.6341.6Functional connections between cells as revealed by dye-coupling with a highly fluorescent naphthalimide tracer. W W StewartCell1978688392Yes
369521461073.043.0721.5A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. C S Hoffman, F WinstonGene19873319781Yes
369610731073.023.4123.4ECM and cell surface proteolysis: regulating cellular ecology. Z WerbCell19979390552No
369710731073.031.0531.1Microbial heavy-metal resistance. D H NiesAppl Microbiol Biotechnol199910422221No
369810731073.032.832.8On the mechanisms of biocompatibility. David F WilliamsBiomaterials200818440630No
369964351072.5174.3229.1Cancer statistics, 2007. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Taylor Murray, Jiaquan Xu, Michael J ThunCA Cancer J Clin200717237035Yes
370021451072.560.430.2Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Amit Etkin, Tor D WagerAm J Psychiatry200717898336Yes
370121441072.082.5741.3Hearing lips and seeing voices. H McGurk, J MacDonaldNature19761012311Yes
370210721072.033.2733.3Food reward: brain substrates of wanting and liking. K C BerridgeNeurosci Biobehav Rev19968622814No
370332161072.0152.2950.8Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG) P L Hudak, P C Amadio, C BombardierAm J Ind Med19968773720Yes
370410721072.029.0829.1Ion suppression in mass spectrometry. Thomas M AnnesleyClin Chem200312816898No
370510721072.028.9128.9A perspective on judgment and choice: mapping bounded rationality. Daniel KahnemanAm Psychol200314584987No
370610721072.029.5629.6Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. John W NewcomerCNS Drugs200515998156No
370710721072.027.3427.3Redefining oxidative stress. Dean P JonesAntioxid Redox Signal200616987039No
370842881072.0241.7460.4The Cambridge Structural Database. Colin R Groom, Ian J Bruno, Matthew P Lightfoot, Suzanna C WardActa Crystallogr B Struct Sci Cryst Eng Mater201627048719Yes
370910711071.018.1218.1Evolution and tinkering. F JacobScience1977860134Yes
371010711071.027.4327.4Unequal treatment: confronting racial and ethnic disparities in health care. Alan NelsonJ Natl Med Assoc200212152921No
371110711071.024.0224.0Liver regeneration. George K MichalopoulosJ Cell Physiol200717559071No
371210711071.028.2628.3Bile acids: regulation of synthesis. John Y L ChiangJ Lipid Res200919346330No
371310701070.029.7529.8Mitochondrial genetics: a paradigm for aging and degenerative diseases? D C WallaceScience19921533953Yes
371410701070.026.3726.4Anti-inflammatory actions of glucocorticoids: molecular mechanisms. P J BarnesClin Sci (Lond)19989854452No
371532101070.075.3125.1Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis. Sang-Dong Yoo, Young-Hee Cho, Jen SheenNat Protoc200717585298Yes
371610701070.031.3531.4Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Gregg L SemenzaTrends Pharmacol Sci201222398146No
371710701070.055.2555.2Systematic text condensation: a strategy for qualitative analysis. Kirsti MalterudScand J Public Health201223221918Yes
371821391069.554.2127.1Antibacterial resistance worldwide: causes, challenges and responses. Stuart B Levy, Bonnie MarshallNat Med200415577930No
371921381069.090.7845.4Severe psoriasis--oral therapy with a new retinoid. T Fredriksson, U PetterssonDermatologica1978357213Yes
372010691069.027.0827.1Axonal growth-associated proteins. J H SkeneAnnu Rev Neurosci19892648946No
372110691069.026.2526.2Biological effects of resveratrol. L FrémontLife Sci200010680575No
372210691069.026.4526.4The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. David S LudwigJAMA200211988062No
372310691069.029.529.5Principles of c-di-GMP signalling in bacteria. Regine HenggeNat Rev Microbiol200919287449No
372421371068.571.4835.7The pathogenesis of atherosclerosis (first of two parts). R Ross, J A GlomsetN Engl J Med1976819830No
372542741068.5110.2227.6A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. I Vermes, C Haanen, H Steffens-Nakken, C ReutelingspergerJ Immunol Methods19957622868Yes
372621361068.059.9530.0Binding of soluble form of fibroblast surface protein, fibronectin, to collagen. E Engvall, E RuoslahtiInt J Cancer1977903179Yes
372710681068.050.250.2Clinical experience with impedance audiometry. J JergerArch Otolaryngol19705455571Yes
372810681068.030.6530.6Muscarinic receptors--characterization, coupling and function. M P CaulfieldPharmacol Ther19937504306No
372921361068.037.4818.7Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. W Gu, R G RoederCell19979288740Yes
373010681068.024.6924.7Structure and signalling in the IL-17 receptor family. Sarah L GaffenNat Rev Immunol200919575028No
373142701067.5109.427.4Real time quantitative PCR. C A Heid, J Stevens, K J Livak, P M WilliamsGenome Res19968908518Yes
3732117411067.4332.9630.3International physical activity questionnaire: 12-country reliability and validity. Cora L Craig, Alison L Marshall, Michael Sjöström, Adrian E Bauman, Michael L Booth, Barbara E Ainsworth, Michael Pratt, Ulf Ekelund, Agneta Yngve, James F Sallis, Pekka OjaMed Sci Sports Exerc200312900694Yes
373310671067.025.8425.8The ultrastructural basis of capillary permeability studied with peroxidase as a tracer. M J KarnovskyJ Cell Biol19676061717Yes
373410671067.030.2430.2Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine. E M TanAdv Immunol19826182766No
373521341067.075.4737.7Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. Hirenkumar K Makadia, Steven J SiegelPolymers (Basel)201122577513Yes
3736106651066.5351.5135.2The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. N K Aaronson, S Ahmedzai, B Bergman, M Bullinger, A Cull, N J Duez, A Filiberti, H Flechtner, S B Fleishman, J C de HaesJ Natl Cancer Inst19938433390Yes
373742641066.0217.354.3National Institute of Mental Health Diagnostic Interview Schedule. Its history, characteristics, and validity. L N Robins, J E Helzer, J Croughan, K S RatcliffArch Gen Psychiatry19816260053Yes
373810661066.024.1624.2The neurobiology of consolidations, or, how stable is the engram? Yadin DudaiAnnu Rev Psychol200414744210No
373931971065.7142.6347.5Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. M Jondal, G Holm, H WigzellJ Exp Med19724114496Yes
374021311065.562.7231.4Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. C N Hales, D J BarkerDiabetologia19921644236No
374131961065.367.4722.55-fluorouracil: mechanisms of action and clinical strategies. Daniel B Longley, D Paul Harkin, Patrick G JohnstonNat Rev Cancer200312724731No
374210651065.038.738.7Attention, similarity, and the identification-categorization relationship. R M NosofskyJ Exp Psychol Gen19862937873Yes
374310651065.027.9527.9Philosophical conceptions of the self: implications for cognitive science. I GallagherTrends Cogn Sci200010637618Yes
374410651065.032.6432.6Social cognition and the brain: a meta-analysis. Frank Van OverwalleHum Brain Mapp200918381770Yes
374510651065.028.3928.4An introduction to data reduction: space-group determination, scaling and intensity statistics. Philip R EvansActa Crystallogr D Biol Crystallogr201121460446Yes
374621301065.079.039.5Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. Claudio Franceschi, Judith CampisiJ Gerontol A Biol Sci Med Sci201424833586No
374721291064.542.0621.0Calcium-dependent bacteriophage DNA infection. M Mandel, A HigaJ Mol Biol19704922220Yes
374810641064.021.7621.8The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells. D MetcalfNature19892469962No
374910641064.052.5352.5The sociological study of stress. L I PearlinJ Health Soc Behav19892674272No
375010641064.029.1629.2Synchronization of cortical activity and its putative role in information processing and learning. W SingerAnnu Rev Physiol19938466179No
375163841064.0176.8929.5Mild cognitive impairment: clinical characterization and outcome. R C Petersen, G E Smith, S C Waring, R J Ivnik, E G Tangalos, E KokmenArch Neurol199910190820Yes
375221281064.054.1127.1Anemia of chronic disease. Guenter Weiss, Lawrence T GoodnoughN Engl J Med200515758012No
375310631063.036.0136.0A colorimetric method for estimating serum triglycerides. M J FletcherClin Chim Acta19685696963Yes
375453151063.0194.0338.8A new clinical scale for the staging of dementia. C P Hughes, L Berg, W L Danziger, L A Coben, R L MartinBr J Psychiatry19827104545Yes
375510631063.022.0822.1Oxidant signals and oxidative stress. Toren FinkelCurr Opin Cell Biol200312648682No
375642521063.0101.3225.3The epidemiology of sepsis in the United States from 1979 through 2000. Greg S Martin, David M Mannino, Stephanie Eaton, Marc MossN Engl J Med200312700374Yes
375710631063.025.8325.8Looking into the functional architecture of the brain with diffusion MRI. Denis Le BihanNat Rev Neurosci200312778119No
375821251062.553.226.6The regulation and function of c-fos and other immediate early genes in the nervous system. M Sheng, M E GreenbergNeuron19901969743No
375921251062.556.2928.1The evolution of cooperation. R Axelrod, W D HamiltonScience19817466396Yes
376010621062.025.5125.5The granulocyte-macrophage colony-stimulating factors. D MetcalfScience19852990035No
376110621062.029.8229.8Junctional intercellular communication: the cell-to-cell membrane channel. W R LoewensteinPhysiol Rev19816270711No
376210621062.030.4630.5Pathogenetic mechanisms of septic shock. J E ParrilloN Engl J Med19938479467No
376310621062.028.6228.6Interval estimation for the difference between independent proportions: comparison of eleven methods. R G NewcombeStat Med19989595617Yes
376410621062.025.525.5Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. Mark E BoutonBiol Psychiatry200212437938No
376521241062.051.9326.0Sulforhodamine B colorimetric assay for cytotoxicity screening. Vanicha Vichai, Kanyawim KirtikaraNat Protoc200617406391Yes
376663701061.7161.7127.0Ghrelin is a growth-hormone-releasing acylated peptide from stomach. M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K KangawaNature199910604470Yes
376753071061.4144.2828.9Biodiversity hotspots for conservation priorities. N Myers, R A Mittermeier, C G Mittermeier, G A da Fonseca, J KentNature200010706275Yes
376810611061.031.6231.6Epidemiology of cancer of the colon and rectum. D P BurkittCancer19715165022Yes
376910611061.032.6732.7Prevention of drug access to bacterial targets: permeability barriers and active efflux. H NikaidoScience19948153625No
377010611061.030.0330.0The mechanisms of alloxan- and streptozotocin-induced diabetes. S LenzenDiabetologia200818087688No
377110611061.00.00.0A Serological Differentiation Of Human And Other Groups Of Hemolytic Streptococci. R C LancefieldJ Exp Med193319870148Yes
377221221061.072.7736.4Photoacoustic tomography: in vivo imaging from organelles to organs. Lihong V Wang, Song HuScience201222442475No
377321221061.0116.6758.3Sexually transmitted diseases treatment guidelines, 2015. Kimberly A Workowski, Gail A BolanMMWR Recomm Rep201526042815No
377431821060.780.9227.0Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions. M Piotto, V Saudek, V SklenárJ Biomol NMR19921490109Yes
377521211060.50.00.0Histochemistry of hepatic phosphatases of a physiologic pH; with special reference to the demonstration of bile canaliculi. M Wachstein, E MeiselAm J Clin Pathol195713410831Yes
377621201060.061.8430.9The biochemistry of P-glycoprotein-mediated multidrug resistance. J A Endicott, V LingAnnu Rev Biochem19892570548No
377710601060.028.3928.4Inhibition of return. R M KleinTrends Cogn Sci200010740278Yes
377821201060.00.00.0Use of glucose oxidase, peroxidase, and O-dianisidine in determination of blood and urinary glucose. A S Huggett, D A NixonLancet195713464070Yes
377910601060.028.3428.3Neuronal gamma-band synchronization as a fundamental process in cortical computation. Pascal FriesAnnu Rev Neurosci200919400723No
378010601060.037.0937.1Stochastic thermodynamics, fluctuation theorems and molecular machines. Udo SeifertRep Prog Phys201223168354No
378121201060.087.6143.8Communication by Extracellular Vesicles: Where We Are and Where We Need to Go. Mercedes Tkach, Clotilde ThéryCell201626967288No
378221191059.532.8616.4The growth of mouse bone marrow cells in vitro. T R Bradley, D MetcalfAust J Exp Biol Med Sci19664164182Yes
378321191059.554.0427.0Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. M S Brown, J L GoldsteinAnnu Rev Biochem19836311077No
378410591059.039.3239.3Infection by verocytotoxin-producing Escherichia coli. M A KarmaliClin Microbiol Rev19892644022No
378510591059.024.4624.5Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. S H KaufmannCancer Res19892790800Yes
378610591059.029.8529.9Determination of total protein. G L PetersonMethods Enzymol19836855607Yes
378710591059.041.541.5Gait changes in older adults: predictors of falls or indicators of fear. B E MakiJ Am Geriatr Soc19979063277Yes
378821181059.047.9724.0The significance of digital gene expression profiles. S Audic, J M ClaverieGenome Res19979331369Yes
378921181059.040.1120.1Wnt signaling: a common theme in animal development. K M Cadigan, R NusseGenes Dev19979407023No
379010591059.018.8618.9Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. W KolchBiochem J200011023813No
379121181059.047.9824.0Effect of pegylation on pharmaceuticals. J Milton Harris, Robert B ChessNat Rev Drug Discov200312612647No
379221181059.00.00.0A microcolorimetric method for the determination of inorganic phosphorus. H H Taussky, E ShorrJ Biol Chem195313061491Yes
379310591059.00.00.0On the Absorption of Fluids from the Connective Tissue Spaces. E H StarlingJ Physiol189616992325Yes
379410591059.027.7827.8Physiology and immunology of the cholinergic antiinflammatory pathway. Kevin J TraceyJ Clin Invest200717273548No
379531771059.086.6328.9Improved vectors and genome-wide libraries for CRISPR screening. Neville E Sanjana, Ophir Shalem, Feng ZhangNat Methods201425075903Yes
379610591059.033.9534.0Isolation By Distance In Equilibrium And Non-Equilibrium Populations. Montgomery SlatkinEvolution199328568097Yes
379742351058.8105.926.5An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Joseph A Maldjian, Paul J Laurienti, Robert A Kraft, Jonathan H BurdetteNeuroimage200312880848Yes
379821171058.579.3939.7A psychomotor stimulant theory of addiction. R A Wise, M A BozarthPsychol Rev19873317472No
379910581058.043.2743.3Movement, posture and equilibrium: interaction and coordination. J MassionProg Neurobiol19921736324No
380021161058.045.322.6The immunoglobulin superfamily--domains for cell surface recognition. A F Williams, A N BarclayAnnu Rev Immunol19883289571No
380110581058.034.6834.7Perceptual load as a necessary condition for selective attention. N LavieJ Exp Psychol Hum Percept Perform19957790827Yes
380210581058.022.7722.8Ligand-targeted therapeutics in anticancer therapy. Theresa M AllenNat Rev Cancer200212360278No
380310581058.029.8129.8Micellar nanocarriers: pharmaceutical perspectives. V P TorchilinPharm Res200717109211No
380410581058.0142.75142.8COVID-19 Vaccine Hesitancy Worldwide: A Concise Systematic Review of Vaccine Acceptance Rates. Malik SallamVaccines (Basel)202133669441No
380521151057.543.0421.5Modified reagents for determination of urea and ammonia. A L Chaney, E P MarbachClin Chem196213878063Yes
380610571057.074.0274.0Root canal anatomy of the human permanent teeth. F J VertucciOral Surg Oral Med Oral Pathol19846595621Yes
380731711057.076.0425.3Nitric oxide and macrophage function. J MacMicking, Q W Xie, C NathanAnnu Rev Immunol19979143691No
380810571057.026.6726.7The potential environmental impact of engineered nanomaterials. Vicki L ColvinNat Biotechnol200314520401Yes
380910571057.00.00.0Neural basis of the spontaneous optokinetic response produced by visual inversion. R W SperryJ Comp Physiol Psychol195014794830Yes
381010571057.022.9623.0Serine/threonine phosphatases: mechanism through structure. Yigong ShiCell200919879837No
381131711057.0118.239.4Stimuli-responsive nanocarriers for drug delivery. Simona Mura, Julien Nicolas, Patrick CouvreurNat Mater201324150417No
381221131056.582.1241.1Comparative aspects of the brain growth spurt. J Dobbing, J SandsEarly Hum Dev1979118862Yes
381321121056.069.0234.5Polymyositis and dermatomyositis (second of two parts). A Bohan, J B PeterN Engl J Med19751089199No
381421121056.080.0740.0Societal and individual determinants of medical care utilization in the United States. R Andersen, J F NewmanMilbank Mem Fund Q Health Soc19734198894Yes
381510561056.028.4528.4T-cell growth factor. K A SmithImmunol Rev19807000676No
381610561056.024.4724.5Biochemistry and genetics of von Willebrand factor. J E SadlerAnnu Rev Biochem19989759493No

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