Unicorn Papers

Top ‱ cited papers from PUBMED

Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authors
Currently, the list contains 3802 papers with ECcit ≥ 1057.5
‱ - permyriad, , literally meaning "for (every) myriad (ten thousand)"

Volume 40, December 2023

No. Citations ECcit RCR ECRCR Title Authors Journal Year PMID Article(?)
1224745224745.05467.725467.7Cleavage of structural proteins during the assembly of the head of bacteriophage T4. U K LaemmliNature19705432063Yes
2172345172345.06782.526782.5A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. M M BradfordAnal Biochem1976942051Yes
328512171280.20.00.0Protein measurement with the Folin phenol reagent. O H Lowry, N J Rosebrough, A L Farr, R J RandallJ Biol Chem195114907713Yes
411919359596.52957.651478.8Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. K J Livak, T D SchmittgenMethods200111846609Yes
54520945209.01394.81394.8A short history of SHELX. George M SheldrickActa Crystallogr A200818156677Yes
63657036570.01177.191177.2Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. T MosmannJ Immunol Methods19836606682Yes
76440132200.51934.45967.2Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. P Chomczynski, N SacchiAnal Biochem19872440339Yes
83026330263.0823.31823.3Detection of specific sequences among DNA fragments separated by gel electrophoresis. E M SouthernJ Mol Biol19751195397Yes
92770127701.0901.89901.9The assessment and analysis of handedness: the Edinburgh inventory. R C OldfieldNeuropsychologia19715146491Yes
102759227592.0609.54609.5MicroRNAs: genomics, biogenesis, mechanism, and function. David P BartelCell200414744438No
112618126181.0619.62619.6MUSCLE: multiple sequence alignment with high accuracy and high throughput. Robert C EdgarNucleic Acids Res200415034147Yes
122571625716.0669.91669.9A rating scale for depression. M HamiltonJ Neurol Neurosurg Psychiatry196014399272Yes
132430124301.0557.48557.5A new mathematical model for relative quantification in real-time RT-PCR. M W PfafflNucleic Acids Res200111328886Yes
142423124231.0751.38751.4Confidence Limits On Phylogenies: An Approach Using The Bootstrap. Joseph FelsensteinEvolution198528561359Yes
156593121977.01650.94550.3DNA sequencing with chain-terminating inhibitors. F Sanger, S Nicklen, A R CoulsonProc Natl Acad Sci U S A1977271968Yes
166562621875.32479.85826.6"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. M F Folstein, S E Folstein, P R McHughJ Psychiatr Res19751202204Yes
174153020765.01308.05654.0Hallmarks of cancer: the next generation. Douglas Hanahan, Robert A WeinbergCell201121376230No
182073120731.0714.34714.3Density-functional exchange-energy approximation with correct asymptotic behavior. A D BeckePhys Rev A Gen Phys19889900728Yes
192030520305.0149.51149.5The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. E S ReynoldsJ Cell Biol196313986422Yes
203942219711.01216.33608.2The neighbor-joining method: a new method for reconstructing phylogenetic trees. N Saitou, M NeiMol Biol Evol19873447015Yes
211947719477.00.00.0Tissue sulfhydryl groups. G L EllmanArch Biochem Biophys195913650640Yes
223583017915.01697.49848.7Statistical methods for assessing agreement between two methods of clinical measurement. J M Bland, D G AltmanLancet19862868172Yes
231789117891.0500.54500.5Projector augmented-wave method. P E BlöchlPhys Rev B Condens Matter19949976227Yes
245354117847.01976.98659.0Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. H Towbin, T Staehelin, J GordonProc Natl Acad Sci U S A1979388439Yes
253467417337.01455.82727.9The measurement of observer agreement for categorical data. J R Landis, G G KochBiometrics1977843571Yes
261700217002.0622.94622.9A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. M KimuraJ Mol Evol19807463489Yes
271687416874.0423.87423.9Atherosclerosis--an inflammatory disease. R RossN Engl J Med19999887164No
281684516845.0649.98650.0Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. B J DavisAnn N Y Acad Sci196414240539Yes
291620916209.0702.54702.5RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Alexandros StamatakisBioinformatics201424451623Yes
301618616186.0449.49449.5High resolution two-dimensional electrophoresis of proteins. P H O'FarrellJ Biol Chem1975236308Yes
313208516042.50.00.0A rapid method of total lipid extraction and purification. E G Bligh, W J DyerCan J Biochem Physiol195913671378Yes
321594215942.00.00.0A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. K BurtonBiochem J195613293190Yes
331576415764.0648.95649.0A power primer. J CohenPsychol Bull199219565683Yes
341523215232.0385.36385.4MicroRNAs: target recognition and regulatory functions. David P BartelCell200919167326No
354518415061.31289.74429.9CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. J D Thompson, D G Higgins, T J GibsonNucleic Acids Res19947984417Yes
364484114947.01329.15443.1Generalized Gradient Approximation Made Simple. J P Perdew, K Burke, M ErnzerhofPhys Rev Lett199610062328Yes
372956514782.51183.67591.8The hospital anxiety and depression scale. A S Zigmond, R P SnaithActa Psychiatr Scand19836880820Yes
382935614678.01102.33551.2Meta-analysis in clinical trials. R DerSimonian, N LairdControl Clin Trials19863802833Yes
392867714338.5923.18461.6Fast gapped-read alignment with Bowtie 2. Ben Langmead, Steven L SalzbergNat Methods201222388286Yes
401422314223.0553.82553.8Catalase in vitro. H AebiMethods Enzymol19846727660Yes
412832114160.5720.19360.1Fast and accurate short read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics200919451168Yes
424144013813.30.00.0A simple method for the isolation and purification of total lipides from animal tissues. J Folch, M Lees, G H Sloane StanleyJ Biol Chem195713428781Yes
433986313287.71500.31500.1Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Michael I Love, Wolfgang Huber, Simon AndersGenome Biol201425516281Yes
441314313143.0691.83691.8Crystal structure refinement with SHELXL. George M SheldrickActa Crystallogr C Struct Chem201525567568Yes
451261012610.00.00.0Phosphorus assay in column chromatography. G R BartlettJ Biol Chem195913641241Yes
466207412414.81776.5355.3Basic local alignment search tool. S F Altschul, W Gish, W Miller, E W Myers, D J LipmanJ Mol Biol19902231712Yes
473691512305.01308.28436.1Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. C Lee, W Yang, R G ParrPhys Rev B Condens Matter19889944570Yes
482445412227.0506.58253.3Coot: model-building tools for molecular graphics. Paul Emsley, Kevin CowtanActa Crystallogr D Biol Crystallogr200415572765Yes
491216212162.0395.75395.8Search and clustering orders of magnitude faster than BLAST. Robert C EdgarBioinformatics201020709691Yes
502423612118.0995.26497.6The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. J E Ware, C D SherbourneMed Care19921593914Yes
512409312046.5528.05264.0Processing of X-ray diffraction data collected in oscillation mode. Z Otwinowski, W MinorMethods Enzymol199727754618Yes
521189111891.0307.69307.7Xds. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124692Yes
532370211851.0650.94325.5Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. G Kresse, J FurthmüllerPhys Rev B Condens Matter19969984901Yes
541174811748.0133.91133.9The genetics of Caenorhabditis elegans. S BrennerGenetics19744366476Yes
551160311603.0381.81381.8Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). J F KurtzkeNeurology19836685237Yes
562308211541.0625.05312.5Quantifying heterogeneity in a meta-analysis. Julian P T Higgins, Simon G ThompsonStat Med200212111919Yes
571152111521.0348.33348.3The Psychophysics Toolbox. D H BrainardSpat Vis19979176952Yes
581142011420.0535.91535.9Self-efficacy: toward a unifying theory of behavioral change. A BanduraPsychol Rev1977847061Yes
592159010795.0558.76279.4A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. A P Feinberg, B VogelsteinAnal Biochem19836312838Yes
601071910719.0409.97410.0A new method for measuring daytime sleepiness: the Epworth sleepiness scale. M W JohnsSleep19911798888Yes
611051910519.0366.07366.1Structure validation in chemical crystallography. Anthony L SpekActa Crystallogr D Biol Crystallogr200919171970Yes
622103310516.5460.8230.4[20] Processing of X-ray diffraction data collected in oscillation mode. Zbyszek Otwinowski, Wladek MinorMethods Enzymol199727799103Yes
631036110361.0203.45203.4Improvements in epoxy resin embedding methods. J H LuftJ Biophys Biochem Cytol196113764136Yes
641034510345.0363.24363.2Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Andreas StangEur J Epidemiol201020652370Yes
653101510338.3807.58269.2VMD: visual molecular dynamics. W Humphrey, A Dalke, K SchultenJ Mol Graph19968744570Yes
663076610255.31225.43408.5Trimmomatic: a flexible trimmer for Illumina sequence data. Anthony M Bolger, Marc Lohse, Bjoern UsadelBioinformatics201424695404Yes
674064110160.21584.56396.1Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanPLoS Med200919621072No
682024510122.5875.75437.9The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. R M Baron, D A KennyJ Pers Soc Psychol19863806354Yes
691009210092.0411.84411.8Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Y KandaBone Marrow Transplant201323208313Yes
704015110037.81150.17287.5Measuring inconsistency in meta-analyses. Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G AltmanBMJ200312958120No
71197919895.5402.77201.4The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. K Weber, M OsbornJ Biol Chem19695806584Yes
72295799859.71011.03337.0NIH Image to ImageJ: 25 years of image analysis. Caroline A Schneider, Wayne S Rasband, Kevin W EliceiriNat Methods201222930834No
73196119805.5763.13381.6MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Kazutaka Katoh, Daron M StandleyMol Biol Evol201323329690Yes
7497449744.00.00.0On the origin of cancer cells. O WarburgScience195613298683Yes
7596399639.0323.83323.8Banting lecture 1988. Role of insulin resistance in human disease. G M ReavenDiabetes19883056758No
7695439543.0268.65268.6Evolutionary trees from DNA sequences: a maximum likelihood approach. J FelsensteinJ Mol Evol19817288891Yes
77189119455.5488.78244.4A simple method for displaying the hydropathic character of a protein. J Kyte, R F DoolittleJ Mol Biol19827108955Yes
7894269426.0196.89196.9Mfold web server for nucleic acid folding and hybridization prediction. Michael ZukerNucleic Acids Res200312824337Yes
79188239411.5406.04203.0KEGG: kyoto encyclopedia of genes and genomes. M Kanehisa, S GotoNucleic Acids Res200010592173Yes
8094019401.0251.58251.6Semiempirical GGA-type density functional constructed with a long-range dispersion correction. Stefan GrimmeJ Comput Chem200616955487Yes
8193289328.0246.73246.7Studies on transformation of Escherichia coli with plasmids. D HanahanJ Mol Biol19836345791Yes
8292629262.0263.44263.4Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. P S ThomasProc Natl Acad Sci U S A19806159641Yes
8392079207.0267.2267.2Vitamin D deficiency. Michael F HolickN Engl J Med200717634462No
8491929192.0239.21239.2RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. Alexandros StamatakisBioinformatics200616928733Yes
8591909190.0396.5396.5Psychophysical bases of perceived exertion. G A BorgMed Sci Sports Exerc19827154893Yes
8691819181.0259.66259.7The pathogenesis of atherosclerosis: a perspective for the 1990s. R RossNature19938479518No
8790719071.0234.11234.1Integrins: versatility, modulation, and signaling in cell adhesion. R O HynesCell19921555235No
88181169058.0381.57190.8The hallmarks of cancer. D Hanahan, R A WeinbergCell200010647931No
8989508950.0265.03265.0The blockade of immune checkpoints in cancer immunotherapy. Drew M PardollNat Rev Cancer201222437870No
90356518912.81309.74327.4A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. M E Charlson, P Pompei, K L Ales, C R MacKenzieJ Chronic Dis19873558716Yes
9187948794.0178.49178.5Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Gordon K SmythStat Appl Genet Mol Biol200416646809Yes
9287058705.0401.75401.8Prokka: rapid prokaryotic genome annotation. Torsten SeemannBioinformatics201424642063Yes
93260338677.7672.11224.0Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Da Wei Huang, Brad T Sherman, Richard A LempickiNat Protoc200919131956Yes
94342708567.51107.37276.8Bias in meta-analysis detected by a simple, graphical test. M Egger, G Davey Smith, M Schneider, C MinderBMJ19979310563Yes
9585378537.0222.07222.1Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. M C HochbergArthritis Rheum19979324032Yes
96170298514.5450.8225.4Analyzing real-time PCR data by the comparative C(T) method. Thomas D Schmittgen, Kenneth J LivakNat Protoc200818546601Yes
9784858485.00.00.0Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. D I ArnonPlant Physiol194916654194Yes
9884828482.0180.22180.2The functions of animal microRNAs. Victor AmbrosNature200415372042No
99169148457.0372.84186.4Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Kazutoshi Takahashi, Shinya YamanakaCell200616904174Yes
10083978397.0221.28221.3Canonical dynamics: Equilibrium phase-space distributions. W G HooverPhys Rev A Gen Phys19859895674Yes
101502498374.83499.86583.3Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin JemalCA Cancer J Clin201830207593Yes
10283748374.0203.02203.0PAML 4: phylogenetic analysis by maximum likelihood. Ziheng YangMol Biol Evol200717483113Yes
10380968096.00.00.0The assessment of anxiety states by rating. M HamiltonBr J Med Psychol195913638508Yes
10480888088.0155.77155.8Solvent content of protein crystals. B W MatthewsJ Mol Biol19685700707Yes
10580688068.0413.6413.6SHELXT - integrated space-group and crystal-structure determination. George M SheldrickActa Crystallogr A Found Adv201525537383Yes
10680018001.0210.64210.6Apoptosis: a review of programmed cell death. Susan ElmoreToxicol Pathol200717562483No
10779697969.0343.86343.9UPARSE: highly accurate OTU sequences from microbial amplicon reads. Robert C EdgarNat Methods201323955772Yes
10879517951.0234.14234.1AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. R W CoxComput Biomed Res19968812068Yes
109238457948.31370.35456.8MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Sudhir Kumar, Glen Stecher, Koichiro TamuraMol Biol Evol201627004904Yes
11078777877.0218.13218.1"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. W N BurnetteAnal Biochem19816266278Yes
11178147814.0216.65216.7The role of protein kinase C in cell surface signal transduction and tumour promotion. Y NishizukaNature19846232463No
11277937793.0225.65225.7A simplification of the protein assay method of Lowry et al. which is more generally applicable. G L PetersonAnal Biochem1977603028Yes
11377447744.0358.59358.6Comparative fit indexes in structural models. P M BentlerPsychol Bull19902320703Yes
114154597729.5377.75188.9MrBayes 3: Bayesian phylogenetic inference under mixed models. Fredrik Ronquist, John P HuelsenbeckBioinformatics200312912839Yes
115231447714.7621.23207.1edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Mark D Robinson, Davis J McCarthy, Gordon K SmythBioinformatics201019910308Yes
11676617661.0227.97228.0Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. J R VaneNat New Biol19715284360Yes
11776407640.0156.39156.4Tumor angiogenesis: therapeutic implications. J FolkmanN Engl J Med19714938153No
11876397639.0205.28205.3Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. F TajimaGenetics19892513255Yes
11976297629.0253.22253.2Density-functional approximation for the correlation energy of the inhomogeneous electron gas. J P PerdewPhys Rev B Condens Matter19869938299Yes
120150837541.5338.04169.0Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. S J Clough, A F BentPlant J199810069079Yes
12174627462.0160.15160.2Chromatin modifications and their function. Tony KouzaridesCell200717320507No
122223357445.0657.35219.1The PHQ-9: validity of a brief depression severity measure. K Kroenke, R L Spitzer, J B WilliamsJ Gen Intern Med200111556941Yes
12374277427.0183.8183.8Fast robust automated brain extraction. Stephen M SmithHum Brain Mapp200212391568No
124147937396.5462.4231.2AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Oleg Trott, Arthur J OlsonJ Comput Chem201019499576Yes
125221567385.3838.89279.6Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. W T Friedewald, R I Levy, D S FredricksonClin Chem19724337382Yes
12673807380.0135.35135.3A low-viscosity epoxy resin embedding medium for electron microscopy. A R SpurrJ Ultrastruct Res19694887011Yes
12773217321.0178.25178.2Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. A BöyumScand J Clin Lab Invest Suppl19684179068Yes
128511947313.41319.89188.6Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J LipmanNucleic Acids Res19979254694No
129142267113.0479.26239.6Three approaches to qualitative content analysis. Hsiu-Fang Hsieh, Sarah E ShannonQual Health Res200516204405Yes
130212737091.0647.4215.8Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Daniel Dindo, Nicolas Demartines, Pierre-Alain ClavienAnn Surg200415273542Yes
13170407040.0191.19191.2TreeView: an application to display phylogenetic trees on personal computers. R D PageComput Appl Biosci19968902363Yes
13270277027.0212.51212.5The VideoToolbox software for visual psychophysics: transforming numbers into movies. D G PelliSpat Vis19979176953Yes
13370147014.0222.45222.4The Clinical Dementia Rating (CDR): current version and scoring rules. J C MorrisNeurology19938232972Yes
134138466923.0356.46178.2Continuous cultures of fused cells secreting antibody of predefined specificity. G Köhler, C MilsteinNature19751172191Yes
13568646864.0185.03185.0The steroid and thyroid hormone receptor superfamily. R M EvansScience19883283939No
136136846842.0328.6164.3BEDTools: a flexible suite of utilities for comparing genomic features. Aaron R Quinlan, Ira M HallBioinformatics201020110278Yes
13767426742.0236.59236.6The Strengths and Difficulties Questionnaire: a research note. R GoodmanJ Child Psychol Psychiatry19979255702Yes
138268486712.0882.23220.6G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel BuchnerBehav Res Methods200717695343Yes
13966926692.00.00.0The thiobarbituric acid assay of sialic acids. L WarrenJ Biol Chem195913672998Yes
14065776577.0172.39172.4Adhesion receptors of the immune system. T A SpringerNature19901974032No
141131166558.0302.2151.1Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Y Cheng, W H PrusoffBiochem Pharmacol19734202581Yes
142196026534.0549.38183.1A new generation of Ca2+ indicators with greatly improved fluorescence properties. G Grynkiewicz, M Poenie, R Y TsienJ Biol Chem19853838314Yes
14365346534.0213.34213.3Ethical guidelines for investigations of experimental pain in conscious animals. Manfred ZimmermannPain19836877845No
14465186518.0168.99169.0Angiogenesis in cancer, vascular, rheumatoid and other disease. J FolkmanNat Med19957584949No
14564646464.0128.54128.5Integrins: bidirectional, allosteric signaling machines. Richard O HynesCell200212297042No
146128886444.0698.51349.3Intraclass correlations: uses in assessing rater reliability. P E Shrout, J L FleissPsychol Bull197918839484No
147128826441.00.00.0Statistical aspects of the analysis of data from retrospective studies of disease. N Mantel, W HaenszelJ Natl Cancer Inst195913655060Yes
14863906390.0128.92128.9Rapid and efficient site-specific mutagenesis without phenotypic selection. T A KunkelProc Natl Acad Sci U S A19853881765Yes
14963366336.0135.58135.6p53, the cellular gatekeeper for growth and division. A J LevineCell19979039259No
15063286328.0167.88167.9A modified poisson regression approach to prospective studies with binary data. Guangyong ZouAm J Epidemiol200415033648Yes
15163076307.0149.16149.2Inflammation, atherosclerosis, and coronary artery disease. Göran K HanssonN Engl J Med200515843671No
152125486274.0348.17174.1EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Arnaud Delorme, Scott MakeigJ Neurosci Methods200415102499Yes
153125106255.0501.22250.6Prediction of creatinine clearance from serum creatinine. D W Cockcroft, M H GaultNephron19761244564Yes
15462356235.0111.5111.5A Self-Rating Depression Scale. W W ZungArch Gen Psychiatry196514221692Yes
155124176208.5425.8212.9The meaning and use of the area under a receiver operating characteristic (ROC) curve. J A Hanley, B J McNeilRadiology19827063747Yes
15661836183.0135.28135.3Inflammation in atherosclerosis. Peter LibbyNature200212490960No
15761556155.0144.16144.2Free radicals in the physiological control of cell function. Wulf DrögePhysiol Rev200211773609No
15861336133.0144.86144.9Biochemistry and molecular cell biology of diabetic complications. M BrownleeNature200111742414Yes
159122586129.0431.54215.8A rapid alkaline extraction procedure for screening recombinant plasmid DNA. H C Birnboim, J DolyNucleic Acids Res1979388356Yes
16061176117.0149.75149.8Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. T A SpringerCell19947507411No
161181696056.3896.24298.7Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. H Ohkawa, N Ohishi, K YagiAnal Biochem197936810Yes
16260426042.0152.48152.5Inositol trisphosphate and calcium signalling. M J BerridgeNature19938381210No
16360366036.0139.02139.0Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. J CastresanaMol Biol Evol200010742046Yes
16460276027.0153.1153.1G proteins: transducers of receptor-generated signals. A G GilmanAnnu Rev Biochem19873113327No
16560116011.00.00.0Index for rating diagnostic tests. W J YoudenCancer195015405679Yes
166240206005.0768.46192.1Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. J M Chirgwin, A E Przybyla, R J MacDonald, W J RutterBiochemistry1979518835Yes
16759795979.0112.47112.5BLAT--the BLAST-like alignment tool. W James KentGenome Res200211932250Yes
16859635963.0208.64208.6An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. Peter C AustinMultivariate Behav Res201121818162Yes
169117745887.0278.23139.1WGCNA: an R package for weighted correlation network analysis. Peter Langfelder, Steve HorvathBMC Bioinformatics200819114008Yes
170117635881.5285.44142.7MRBAYES: Bayesian inference of phylogenetic trees. J P Huelsenbeck, F RonquistBioinformatics200111524383Yes
17158795879.0142.62142.6Inflammation and metabolic disorders. Gökhan S HotamisligilNature200617167474No
17258515851.0135.41135.4Antimicrobial peptides of multicellular organisms. Michael ZasloffNature200211807545Yes
173115055752.5324.89162.4RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. Bo Li, Colin N DeweyBMC Bioinformatics201121816040Yes
174114905745.0264.91132.5Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. W Kabsch, C SanderBiopolymers19836667333Yes
17557425742.0171.71171.7Modification of seizure activity by electrical stimulation. II. Motor seizure. R J RacineElectroencephalogr Clin Neurophysiol19724110397Yes
17657265726.0143.2143.2Apoptosis in the pathogenesis and treatment of disease. C B ThompsonScience19957878464No
177113925696.0251.8125.9Dendritic cells and the control of immunity. J Banchereau, R M SteinmanNature19989521319No
178113755687.5442.39221.2The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. T Omura, R SatoJ Biol Chem196414209971Yes
179113135656.5308.89154.4Neuropathological stageing of Alzheimer-related changes. H Braak, E BraakActa Neuropathol19911759558No
180113105655.0247.85123.9One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. K A Datsenko, B L WannerProc Natl Acad Sci U S A200010829079Yes
18156285628.073.873.8The Environment And Disease: Association Or Causation? A B HillProc R Soc Med196514283879Yes
182111905595.00.00.0A series of normal stages in the development of the chick embryo. V Hamburger, H L HamiltonJ Morphol195124539719Yes
183111495574.5293.53146.8Sequencing end-labeled DNA with base-specific chemical cleavages. A M Maxam, W GilbertMethods Enzymol19806246368Yes
18455655565.00.00.0Aging: a theory based on free radical and radiation chemistry. D HarmanJ Gerontol195613332224Yes
18555565556.0100.94100.9Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. F TietzeAnal Biochem19694388022Yes
18655545554.0176.69176.7jModelTest: phylogenetic model averaging. David PosadaMol Biol Evol200818397919Yes
18755345534.0155.25155.2A fast diffeomorphic image registration algorithm. John AshburnerNeuroimage200717761438Yes
18855195519.0133.33133.3Development of a rating scale for primary depressive illness. M HamiltonBr J Soc Clin Psychol19676080235Yes
18955135513.0120.13120.1The biochemistry of apoptosis. M O HengartnerNature200011048727No
190110035501.5291.98146.0Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. Florian Weigend, Reinhart AhlrichsPhys Chem Chem Phys200516240044Yes
19154775477.0217.19217.2Orienting of attention. M I PosnerQ J Exp Psychol19807367577Yes
19254765476.0121.68121.7MUSCLE: a multiple sequence alignment method with reduced time and space complexity. Robert C EdgarBMC Bioinformatics200415318951Yes
193109285464.0254.63127.3A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Stéphane Guindon, Olivier GascuelSyst Biol200314530136Yes
19454605460.096.1796.2Mutation and cancer: statistical study of retinoblastoma. A G KnudsonProc Natl Acad Sci U S A19715279523Yes
19554515451.0105.32105.3Evaluation of survival data and two new rank order statistics arising in its consideration. N MantelCancer Chemother Rep19665910392Yes
196163305443.3491.3163.8A simple salting out procedure for extracting DNA from human nucleated cells. S A Miller, D D Dykes, H F PoleskyNucleic Acids Res19883344216Yes
197379225417.46713.1959.0Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie BrayCA Cancer J Clin202133538338Yes
19853675367.0138.63138.6The Cambridge Structural Database: a quarter of a million crystal structures and rising. Frank H AllenActa Crystallogr B200212037359Yes
19953585358.0136.34136.3New M13 vectors for cloning. J MessingMethods Enzymol19836310323Yes
200106915345.5298.7149.3MODELTEST: testing the model of DNA substitution. D Posada, K A CrandallBioinformatics19989918953Yes
201106705335.0226.91113.5Inflammation and cancer. Lisa M Coussens, Zena WerbNature200212490959No
20253005300.0157.01157.0Developments of a water-maze procedure for studying spatial learning in the rat. R MorrisJ Neurosci Methods19846471907Yes
203105965298.0744.33372.2A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. Terry K Koo, Mae Y LiJ Chiropr Med201627330520Yes
20452955295.0128.03128.0The NF-kappa B and I kappa B proteins: new discoveries and insights. A S BaldwinAnnu Rev Immunol19968717528No
20552855285.0152.99153.0Studies and perspectives of protein kinase C. Y NishizukaScience19863014651No
206264215284.2712.99142.6The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G HigginsNucleic Acids Res19979396791Yes
207105295264.51034.96517.5Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. Zunyou Wu, Jennifer M McGooganJAMA202032091533Yes
20852285228.0102.19102.2Epithelial-mesenchymal transitions in tumour progression. Jean Paul ThieryNat Rev Cancer200212189386No
209104465223.0270.5135.2Differential expression analysis for sequence count data. Simon Anders, Wolfgang HuberGenome Biol201020979621Yes
21052195219.00.00.0[A micro-method of immuno-electrophoresis]. J J ScheideggerInt Arch Allergy Appl Immunol195513262900Yes
21152125212.0189.08189.1Oxygen-derived free radicals in postischemic tissue injury. J M McCordN Engl J Med19852981404No
212104075203.50.00.0A quantitative description of membrane current and its application to conduction and excitation in nerve. A L Hodgkin, A F HuxleyJ Physiol195212991237Yes
213103985199.0344.37172.2Operating characteristics of a rank correlation test for publication bias. C B Begg, M MazumdarBiometrics19947786990Yes
214155815193.7552.71184.2Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Allison Tong, Peter Sainsbury, Jonathan CraigInt J Qual Health Care200717872937Yes
21551925192.066.1766.2Selective extraction of polyoma DNA from infected mouse cell cultures. B HirtJ Mol Biol19674291934Yes
216155315177.0583.96194.7The positive and negative syndrome scale (PANSS) for schizophrenia. S R Kay, A Fiszbein, L A OplerSchizophr Bull19873616518Yes
217103505175.0483.02241.5A new depression scale designed to be sensitive to change. S A Montgomery, M AsbergBr J Psychiatry1979444788Yes
21851645164.0136.66136.7Mild cognitive impairment as a diagnostic entity. R C PetersenJ Intern Med200415324362No
219103105155.0365.93183.0The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. R F Furchgott, J V ZawadzkiNature19806253831Yes
22051545154.052.9653.0The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. P LaurenActa Pathol Microbiol Scand196514320675Yes
22151405140.0170.87170.9Whatever happened to qualitative description? M SandelowskiRes Nurs Health200010940958No
22251315131.0187.98188.0Analyzing Tables Of Statistical Tests. William R RiceEvolution198928568501Yes
223102195109.5271.75135.9Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. H Schägger, G von JagowAnal Biochem19872449095Yes
22451045104.0157.09157.1Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. Ilan H MeyerPsychol Bull200312956539No
22550925092.0101.56101.6Rho GTPases and the actin cytoskeleton. A HallScience19989438836No
22650855085.0124.24124.2Emotion circuits in the brain. J E LeDouxAnnu Rev Neurosci200010845062No
22750765076.0139.69139.7How mitochondria produce reactive oxygen species. Michael P MurphyBiochem J200919061483No
228101355067.5241.44120.7Comparative protein modelling by satisfaction of spatial restraints. A Sali, T L BlundellJ Mol Biol19938254673Yes
229151975065.7375.21125.1Inference of population structure using multilocus genotype data. J K Pritchard, M Stephens, P DonnellyGenetics200010835412Yes
230100765038.0219.05109.5The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. John Hardy, Dennis J SelkoeScience200212130773No
23150175017.0191.3191.3Revisiting the behavioral model and access to medical care: does it matter? R M AndersenJ Health Soc Behav19957738325Yes
23250155015.0101.57101.6Targeting HIF-1 for cancer therapy. Gregg L SemenzaNat Rev Cancer200313130303No
23349884988.0145.41145.4A protein binding assay for adenosine 3':5'-cyclic monophosphate. A G GilmanProc Natl Acad Sci U S A19704318781Yes
234149354978.3538.2179.4Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. S M Hsu, L Raine, H FangerJ Histochem Cytochem19816166661Yes
23599254962.5219.17109.6MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Jürgen Cox, Matthias MannNat Biotechnol200819029910Yes
23649324932.0140.95140.9Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. C B LaurellAnal Biochem19665959431Yes
237245884917.61087.41217.5MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir KumarMol Biol Evol201324132122Yes
23849174917.0223.67223.7Interrater reliability: the kappa statistic. Mary L McHughBiochem Med (Zagreb)201223092060Yes
23998064903.0350.69175.3Ligand: a versatile computerized approach for characterization of ligand-binding systems. P J Munson, D RodbardAnal Biochem19806254391Yes
24048954895.0191.82191.8The need for a new medical model: a challenge for biomedicine. G L EngelScience1977847460Yes
24197884894.0233.91117.0A genetic model for colorectal tumorigenesis. E R Fearon, B VogelsteinCell19902188735No
242146074869.0392.22130.7Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. C Yanisch-Perron, J Vieira, J MessingGene19852985470Yes
24348664866.0110.12110.1Tandem repeats finder: a program to analyze DNA sequences. G BensonNucleic Acids Res19999862982Yes
24448604860.0110.14110.1The clonal evolution of tumor cell populations. P C NowellScience1976959840Yes
24548494849.097.9898.0An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. M KozakNucleic Acids Res19873313277No
246144904830.01100.06366.7Cancer statistics, 2019. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201930620402Yes
247144734824.3357.73119.2A comprehensive set of sequence analysis programs for the VAX. J Devereux, P Haeberli, O SmithiesNucleic Acids Res19846546423Yes
24847834783.089.9189.9DNA methylation patterns and epigenetic memory. Adrian BirdGenes Dev200211782440No
249143304776.70.00.0Determination of serum proteins by means of the biuret reaction. A G Gornall, C J Bardawill, M M DavidJ Biol Chem194918110453Yes
25047684768.0131.38131.4Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. M RodbellJ Biol Chem196414169133Yes
251238314766.2406.9281.4An inventory for measuring depression. A T Beck, C H Ward, M Mendelson, J Mock, J ErbaughArch Gen Psychiatry196113688369Yes
252190384759.5492.7123.2Features and development of Coot. P Emsley, B Lohkamp, W G Scott, K CowtanActa Crystallogr D Biol Crystallogr201020383002Yes
25347574757.0104.5104.5Cancer cell cycles. C J SherrScience19968939849No
25495114755.5155.6977.8A new technique for the assay of infectivity of human adenovirus 5 DNA. F L Graham, A J van der EbVirology19734705382Yes
25547464746.0106.43106.4ras oncogenes in human cancer: a review. J L BosCancer Res19892547513No
25694564728.0256.17128.1The rise of graphene. A K Geim, K S NovoselovNat Mater200717330084Yes
25747254725.0157.75157.8Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. W H HarrisJ Bone Joint Surg Am19695783851Yes
25847214721.0223.42223.4Executive functions. Adele DiamondAnnu Rev Psychol201323020641No
25994074703.5237.66118.8Improved tools for biological sequence comparison. W R Pearson, D J LipmanProc Natl Acad Sci U S A19883162770Yes
26047034703.0156.99157.0The pathogenesis of atherosclerosis--an update. R RossN Engl J Med19863511384No
26146814681.077.1877.2Aggregation of blood platelets by adenosine diphosphate and its reversal. G V BornNature196213871375Yes
26246764676.0103.28103.3Alzheimer's disease: genes, proteins, and therapy. D J SelkoePhysiol Rev200111274343No
26393474673.5209.02104.5Parkinsonism: onset, progression and mortality. M M Hoehn, M D YahrNeurology19676067254Yes
26446684668.0129.89129.9Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. P MatsudairaJ Biol Chem19873611052Yes
26546644664.0212.42212.4The McGill Pain Questionnaire: major properties and scoring methods. Ronald MelzackPain19751235985Yes
26646534653.0125.92125.9A rapid banding technique for human chromosomes. M SeabrightLancet19714107917Yes
267139464648.7305.26101.8Refinement of macromolecular structures by the maximum-likelihood method. G N Murshudov, A A Vagin, E J DodsonActa Crystallogr D Biol Crystallogr199715299926Yes
268139084636.01387.55462.5Cancer statistics, 2020. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin202031912902Yes
269185344633.5534.96133.7MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir KumarMol Biol Evol200717488738Yes
270138984632.7480.53160.2Nitric oxide: physiology, pathophysiology, and pharmacology. S Moncada, R M Palmer, E A HiggsPharmacol Rev19911852778No
271276894614.8977.66162.9Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G CondeJ Biomed Inform200918929686Yes
27246014601.0102.15102.2Prions. S B PrusinerProc Natl Acad Sci U S A19989811807No
273183894597.2296.7674.2A new and rapid colorimetric determination of acetylcholinesterase activity. G L Ellman, K D Courtney, V Andres, R M Feather-StoneBiochem Pharmacol196113726518Yes
27445794579.040.3840.4The Limited In Vitro Lifetime Of Human Diploid Cell Strains. L HayflickExp Cell Res196514315085Yes
27591114555.5182.1291.1Assessment of older people: self-maintaining and instrumental activities of daily living. M P Lawton, E M BrodyGerontologist19695349366Yes
27690974548.5249.49124.7Ab initio molecular dynamics for liquid metals. G Kresse, J HafnerPhys Rev B Condens Matter199310004490Yes
27745344534.0141.83141.8Updating P300: an integrative theory of P3a and P3b. John PolichClin Neurophysiol200717573239No
27845274527.098.1398.1ras genes. M BarbacidAnnu Rev Biochem19873304147No
27990424521.0330.93165.5Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Kristopher J Preacher, Andrew F HayesBehav Res Methods200818697684Yes
28045204520.0109.05109.0The genetical evolution of social behaviour. I. W D HamiltonJ Theor Biol19645875341Yes
28190394519.5309.81154.9Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. U H Graneheim, B LundmanNurse Educ Today200414769454No
28245144514.093.2693.3Alternative activation of macrophages. Siamon GordonNat Rev Immunol200312511873No
28390264513.0200.98100.5Primer3 on the WWW for general users and for biologist programmers. S Rozen, H SkaletskyMethods Mol Biol200010547847Yes
28490174508.5150.1475.1Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J M McCord, I FridovichJ Biol Chem19695389100Yes
28544744474.0108.54108.5A new method for predicting signal sequence cleavage sites. G von HeijneNucleic Acids Res19863714490Yes
28689064453.00.00.0A simplified method of evaluating dose-effect experiments. J T Litchfield, F WilcoxonJ Pharmacol Exp Ther194918152921Yes
28744524452.090.1290.1Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. M KozakCell19863943125Yes
28844454445.0102.69102.7Cancer. p53, guardian of the genome. D P LaneNature19921614522No
28988694434.5146.9573.5Functional Evaluation: The Barthel Index. F I Mahoney, D W BarthelMd State Med J196514258950Yes
290265944432.3930.29155.0Global cancer statistics. Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David FormanCA Cancer J Clin201121296855Yes
29188384419.0237.09118.5A synaptic model of memory: long-term potentiation in the hippocampus. T V Bliss, G L CollingridgeNature19938421494No
29288214410.5211.41105.7Collective dynamics of 'small-world' networks. D J Watts, S H StrogatzNature19989623998Yes
293132304410.0583.05194.3Development and validation of brief measures of positive and negative affect: the PANAS scales. D Watson, L A Clark, A TellegenJ Pers Soc Psychol19883397865Yes
29444094409.0220.98221.0Minimap2: pairwise alignment for nucleotide sequences. Heng LiBioinformatics201829750242Yes
29587954397.5161.180.5A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. W M Bonner, R A LaskeyEur J Biochem19744850204Yes
29643954395.0164.22164.2FreeSurfer. Bruce FischlNeuroimage201222248573No
29787864393.0221.86110.9Assessment of coma and impaired consciousness. A practical scale. G Teasdale, B JennettLancet19744136544Yes
298131684389.3523.33174.4A global measure of perceived stress. S Cohen, T Kamarck, R MermelsteinJ Health Soc Behav19836668417Yes
29987684384.0202.87101.4SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. N Guex, M C PeitschElectrophoresis19979504803Yes
30043584358.090.0190.0Wnt/beta-catenin signaling in development and disease. Hans CleversCell200617081971No
30143564356.0218.95218.9Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. M M MesulamJ Histochem Cytochem197824068Yes
30243534353.083.3483.3The phosphoinositide 3-kinase pathway. Lewis C CantleyScience200212040186No
30343484348.0112.46112.5Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Y NishizukaScience19921411571No
30443464346.0103.53103.5Why most published research findings are false. John P A IoannidisPLoS Med200516060722Yes
30543214321.0101.37101.4Mechanisms of angiogenesis. W RisauNature19979109485No
306259034317.2959.28159.9MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir KumarMol Biol Evol201121546353Yes
307129274309.0652.99217.7Cancer statistics, 2016. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201626742998Yes
30886144307.0124.1262.1Preparation of iodine-131 labelled human growth hormone of high specific activity. W M Hunter, F C GreenwoodNature196214450081Yes
30943064306.0129.22129.2Glutamate neurotoxicity and diseases of the nervous system. D W ChoiNeuron19882908446No
31086084304.0232.29116.1Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii. Daniel E Voth, Robert A HeinzenCell Microbiol200717381428No
31142834283.0113.73113.7The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Y NishizukaNature19883045562No
31242814281.093.1893.2Apoptosis by death factor. S NagataCell19979039262No
31342594259.0154.95154.9EuroQol: the current state of play. R BrooksHealth Policy199610158943No
31442574257.0110.85110.8Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. A H WyllieNature19806245367Yes
31542504250.00.00.0Amino acid metabolism in mammalian cell cultures. H EagleScience195913675766Yes
31642494249.00.00.0Estimation of nuclear population from microtome sections. M AbercrombieAnat Rec194621015608Yes
31742384238.00.00.0The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. T NashBiochem J195313105648Yes
31842324232.00.00.0Evolution in Mendelian Populations. S WrightGenetics193117246615Yes
31942314231.079.979.9The detection of disease clustering and a generalized regression approach. N MantelCancer Res19676018555Yes
32042194219.093.8993.9Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. S HenikoffGene19846235151Yes
32142194219.087.4687.5The retinoblastoma protein and cell cycle control. R A WeinbergCell19957736585No
32242164216.00.00.0New methods for calculating metabolic rate with special reference to protein metabolism. J B De B WeirJ Physiol194915394301Yes
32342044204.00.00.0A relation between non-esterified fatty acids in plasma and the metabolism of glucose. V P DoleJ Clin Invest195613286333Yes
324125974199.0788.2262.7Cancer statistics, 2018. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201829313949Yes
32583914195.5310.59155.3The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. I F Benzie, J J StrainAnal Biochem19968660627Yes
32683794189.5242.77121.4Estimating F-Statistics For The Analysis Of Population Structure. B S Weir, C Clark CockerhamEvolution198428563791Yes
32741834183.075.7675.8Generalized lacZ expression with the ROSA26 Cre reporter strain. P SorianoNat Genet19999916792Yes
32883644182.0346.7173.3The timed "Up & Go": a test of basic functional mobility for frail elderly persons. D Podsiadlo, S RichardsonJ Am Geriatr Soc19911991946Yes
32941814181.087.1887.2Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. C J MarshallCell19957834738No
330125304176.7402.48134.2Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. E R DeLong, D M DeLong, D L Clarke-PearsonBiometrics19883203132Yes
33141764176.090.8690.9Atherosclerosis. A J LusisNature200011001066No
332124864162.0461.38153.8HTSeq--a Python framework to work with high-throughput sequencing data. Simon Anders, Paul Theodor Pyl, Wolfgang HuberBioinformatics201525260700Yes
33341524152.0156.13156.1Measuring the accuracy of diagnostic systems. J A SwetsScience19883287615No
33441514151.050.4750.5Bone: formation by autoinduction. M R UristScience19655319761Yes
33541504150.0167.29167.3Determination of protein: a modification of the Lowry method that gives a linear photometric response. E F HartreeAnal Biochem19724115981Yes
33641504150.088.7988.8Protein production by auto-induction in high density shaking cultures. F William StudierProtein Expr Purif200515915565Yes
337248944149.0812.72135.5Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C TurnerDiabetologia19853899825Yes
33882924146.00.00.0Radiological assessment of osteo-arthrosis. J H Kellgren, J S LawrenceAnn Rheum Dis195713498604Yes
33941414141.00.00.0The determination of enzyme inhibitor constants. M DixonBiochem J195313093635Yes
34082784139.0177.788.8Genomic sequencing. G M Church, W GilbertProc Natl Acad Sci U S A19846326095Yes
34141154115.0107.46107.5Staphylococcus aureus infections. F D LowyN Engl J Med19989709046No
34241074107.091.2391.2PAML: a program package for phylogenetic analysis by maximum likelihood. Z YangComput Appl Biosci19979367129Yes
34381984099.0343.31171.7phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. Paul J McMurdie, Susan HolmesPLoS One201323630581Yes
344122974099.0548.56182.9Deep learning. Yann LeCun, Yoshua Bengio, Geoffrey HintonNature201526017442No
34540954095.0110.58110.6Mesenchymal stem cells. A I CaplanJ Orthop Res19911870029Yes
34640854085.0127.6127.6Bacterial evolution. C R WoeseMicrobiol Rev19872439888No
347163334083.2522.32130.6A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge KriegJ Chem Phys201020423165Yes
348122294076.3452.69150.9A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. J Ware, M Kosinski, S D KellerMed Care19968628042Yes
349162034050.8612.99153.2Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanAnn Intern Med200919622511No
350283054043.6626.4589.5UCSF Chimera--a visualization system for exploratory research and analysis. Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E FerrinJ Comput Chem200415264254Yes
35180734036.5259.89129.9DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. P Librado, J RozasBioinformatics200919346325Yes
35280664033.0209.36104.7Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. D E Paglia, W N ValentineJ Lab Clin Med19676066618Yes
35340334033.083.7983.8The green fluorescent protein. R Y TsienAnnu Rev Biochem19989759496No
35440224022.0173.38173.4A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. E PfeifferJ Am Geriatr Soc19751159263Yes
35540174017.0103.69103.7Integrins: a family of cell surface receptors. R O HynesCell19873028640No
356120044001.3651.35217.1Cancer Statistics, 2017. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201728055103Yes
35740014001.00.00.0Staining of tissue sections for electron microscopy with heavy metals. M L WatsonJ Biophys Biochem Cytol195813563554Yes
35839893989.0101.34101.3The Scree Test For The Number Of Factors. R B CattellMultivariate Behav Res196626828106Yes
35939853985.0106.89106.9What is the evidence that tumors are angiogenesis dependent? J FolkmanJ Natl Cancer Inst19901688381No
36039833983.078.6378.6Hypoxia--a key regulatory factor in tumour growth. Adrian L HarrisNat Rev Cancer200211902584No
36139773977.0127.92127.9Tissue destruction by neutrophils. S J WeissN Engl J Med19892536474No
36239673967.0115.68115.7Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. D VanderbiltPhys Rev B Condens Matter19909993096Yes
36379333966.5202.77101.4tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. T M Lowe, S R EddyNucleic Acids Res19979023104Yes
36479313965.5298.77149.4Multiwfn: a multifunctional wavefunction analyzer. Tian Lu, Feiwu ChenJ Comput Chem201222162017Yes
36539613961.068.8668.9Principles that govern the folding of protein chains. C B AnfinsenScience19734124164Yes
36639513951.0126.07126.1How do you feel--now? The anterior insula and human awareness. A D Bud CraigNat Rev Neurosci200919096369No
36739493949.0121.35121.3Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. J CohenPsychol Bull196819673146Yes
36839453945.0147.16147.2Disc Electrophoresis. I. Background And Theory. L OrnsteinAnn N Y Acad Sci196414240533Yes
369157423935.5579.02144.8Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanBMJ200919622551No
37078653932.5212.85106.4Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. H Aviv, P LederProc Natl Acad Sci U S A19724504350Yes
37139273927.096.8696.9Multiple sequence alignment with hierarchical clustering. F CorpetNucleic Acids Res19882849754Yes
37278513925.5147.8473.9A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. R S Sikorski, P HieterGenetics19892659436Yes
37339253925.0145.31145.3A concordance correlation coefficient to evaluate reproducibility. L I LinBiometrics19892720055Yes
37439013901.0120.26120.3Nitric oxide as a secretory product of mammalian cells. C NathanFASEB J19921381691No
375116683889.3305.4101.8Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. J F Kerr, A H Wyllie, A R CurrieBr J Cancer19724561027No
37638823882.0121.18121.2Emerging adulthood. A theory of development from the late teens through the twenties. J J ArnettAm Psychol200010842426Yes
37738823882.098.4598.5Oxidative stress, antioxidants and stress tolerance. Ron MittlerTrends Plant Sci200212234732No
378116453881.7298.099.3Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. W H Habig, M J Pabst, W B JakobyJ Biol Chem19744436300Yes
37977593879.5197.4298.7Control of goal-directed and stimulus-driven attention in the brain. Maurizio Corbetta, Gordon L ShulmanNat Rev Neurosci200211994752No
38038793879.080.3880.4Protein secondary structure prediction based on position-specific scoring matrices. D T JonesJ Mol Biol199910493868Yes
38138673867.083.8783.9Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Rakesh K JainScience200515637262No
38238663866.0125.2125.2Preparation of isolated rat liver cells. P O SeglenMethods Cell Biol1976177845No
38338663866.0118.9118.9Pharmacological implications of microsomal enzyme induction. A H ConneyPharmacol Rev19674383307Yes
38477243862.0215.36107.7Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. S Duval, R TweedieBiometrics200010877304Yes
38538563856.0186.18186.2Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Daniël LakensFront Psychol201324324449No
38638543854.0128.12128.1Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Russell A BarkleyPsychol Bull19979000892No
38738453845.0102.18102.2Observational study of behavior: sampling methods. J AltmannBehaviour19744597405No
38838373837.0102.36102.4Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. R B D'AgostinoStat Med19989802183Yes
38938263826.083.8283.8Folding DNA to create nanoscale shapes and patterns. Paul W K RothemundNature200616541064Yes
39038233823.091.2291.2Caspases: the executioners of apoptosis. G M CohenBiochem J19979337844No
39176453822.5144.3172.2Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. A H Brand, N PerrimonDevelopment19938223268Yes
39238123812.0102.86102.9Revisions in the International System for Staging Lung Cancer. C F MountainChest19979187198Yes
39337953795.097.9698.0Sequencing technologies - the next generation. Michael L MetzkerNat Rev Genet201019997069No
39437913791.080.2880.3A catalogue of splice junction sequences. S M MountNucleic Acids Res19827063411Yes
395341183790.9869.2396.6The Sequence Alignment/Map format and SAMtools. Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard DurbinBioinformatics200919505943Yes
39637843784.096.9597.0Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Kim A BrogdenNat Rev Microbiol200515703760No
39737783778.084.1984.2Instability and decay of the primary structure of DNA. T LindahlNature19938469282No
39837783778.077.7177.7TGF-beta signal transduction. J MassaguéAnnu Rev Biochem19989759503No
39975503775.0182.3391.2Mitochondria and apoptosis. D R Green, J C ReedScience19989721092No
40037713771.073.8673.9Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. G R MartinProc Natl Acad Sci U S A19816950406Yes
40137683768.094.7294.7The origins and the future of microfluidics. George M WhitesidesNature200616871203No
40237613761.0149.18149.2Estimation of the molecular weights of proteins by Sephadex gel-filtration. P AndrewsBiochem J19644158310Yes
40337553755.0107.28107.3Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. J H MorrisseyAnal Biochem19816172996Yes
404112393746.3375.21125.1featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Yang Liao, Gordon K Smyth, Wei ShiBioinformatics201424227677Yes
405149813745.2453.83113.5clusterProfiler: an R package for comparing biological themes among gene clusters. Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu HeOMICS201222455463Yes
40637413741.089.089.0Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. A T BrüngerNature199218481394Yes
407112223740.7215.571.8Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. J D Dignam, R M Lebovitz, R G RoederNucleic Acids Res19836828386Yes
40837373737.086.8686.9Novel proteinaceous infectious particles cause scrapie. S B PrusinerScience19826801762Yes
409149273731.8351.8588.0Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Ben Langmead, Cole Trapnell, Mihai Pop, Steven L SalzbergGenome Biol200919261174Yes
41037283728.0107.79107.8What's wrong with Bonferroni adjustments. T V PernegerBMJ19989553006No
41137283728.0100.47100.5Drug combination studies and their synergy quantification using the Chou-Talalay method. Ting-Chao ChouCancer Res201020068163Yes
41237273727.079.6979.7Scaling and assessment of data quality. Philip EvansActa Crystallogr D Biol Crystallogr200616369096No
41337153715.0107.21107.2Functions of DNA methylation: islands, start sites, gene bodies and beyond. Peter A JonesNat Rev Genet201222641018No
414148593714.8384.5196.1Global cancer statistics, 2002. D Max Parkin, Freddie Bray, J Ferlay, Paola PisaniCA Cancer J Clin200515761078Yes
41537083708.0117.41117.4genepop'007: a complete re-implementation of the genepop software for Windows and Linux. François RoussetMol Ecol Resour200821585727Yes
41674153707.5207.46103.7BEAST: Bayesian evolutionary analysis by sampling trees. Alexei J Drummond, Andrew RambautBMC Evol Biol200717996036Yes
41737073707.061.561.5A membrane-filter technique for the detection of complementary DNA. D T DenhardtBiochem Biophys Res Commun19665963888Yes
41836993699.067.067.0Somatic generation of antibody diversity. S TonegawaNature19836300689No
41936983698.092.0192.0Origin and physiological roles of inflammation. Ruslan MedzhitovNature200818650913No
42036903690.0167.35167.3Basic principles of ROC analysis. C E MetzSemin Nucl Med1978112681Yes
42136733673.0125.39125.4Generalized expectancies for internal versus external control of reinforcement. J B RotterPsychol Monogr19665340840No
42273343667.0161.8180.9Functional rafts in cell membranes. K Simons, E IkonenNature19979177342No
42373053652.5182.1491.1Fast and accurate long-read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics201020080505Yes
42436513651.0101.12101.1Biological roles of oligosaccharides: all of the theories are correct. A VarkiGlycobiology19938490246No
42572943647.0185.9393.0The basics of epithelial-mesenchymal transition. Raghu Kalluri, Robert A WeinbergJ Clin Invest200919487818No
42636463646.0105.34105.3Protective and damaging effects of stress mediators. B S McEwenN Engl J Med19989428819No
42736403640.088.9589.0I-TASSER server for protein 3D structure prediction. Yang ZhangBMC Bioinformatics200818215316Yes
42872533626.5183.9392.0The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. R C Graham, M J KarnovskyJ Histochem Cytochem19665962951Yes
429108613620.3421.98140.7HISAT: a fast spliced aligner with low memory requirements. Daehwan Kim, Ben Langmead, Steven L SalzbergNat Methods201525751142Yes
43036183618.0108.71108.7Inositol trisphosphate and diacylglycerol as second messengers. M J BerridgeBiochem J19846146314No
43136173617.0103.04103.0Graphene: status and prospects. A K GeimScience200919541989Yes
43272333616.5161.1280.6Inference of macromolecular assemblies from crystalline state. Evgeny Krissinel, Kim HenrickJ Mol Biol200717681537Yes
433180813616.2695.55139.1The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. D J Buysse, C F Reynolds, T H Monk, S R Berman, D J KupferPsychiatry Res19892748771Yes
43436053605.094.1394.1The adolescent brain and age-related behavioral manifestations. L P SpearNeurosci Biobehav Rev200010817843No
43572043602.0244.15122.1FLASH: fast length adjustment of short reads to improve genome assemblies. Tanja Magoč, Steven L SalzbergBioinformatics201121903629Yes
43636013601.0101.03101.0EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. W KlimeschBrain Res Brain Res Rev199910209231No
43772013600.5173.6186.8The plant immune system. Jonathan D G Jones, Jeffery L DanglNature200617108957No
43872003600.0180.6790.3An integrative theory of prefrontal cortex function. E K Miller, J D CohenAnnu Rev Neurosci200111283309No
43971863593.0250.14125.1Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Laurent Excoffier, Heidi E L LischerMol Ecol Resour201021565059Yes
44035913591.084.5684.6Marrow stromal cells as stem cells for nonhematopoietic tissues. D J ProckopScience19979082988No
441214953582.51005.25167.5Global cancer statistics, 2012. Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin JemalCA Cancer J Clin201525651787Yes
44235793579.084.3984.4Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Ting-Chao ChouPharmacol Rev200616968952No
44370953547.5358.28179.1Microsomal lipid peroxidation. J A Buege, S D AustMethods Enzymol1978672633Yes
44435473547.071.2371.2Mammalian neural stem cells. F H GageScience200010688783No
44570803540.0286.19143.1The qualitative content analysis process. Satu Elo, Helvi KyngäsJ Adv Nurs200818352969Yes
44635153515.066.9166.9Signal transduction by the JNK group of MAP kinases. R J DavisCell200011057897No
44735133513.091.0191.0Microglia: a sensor for pathological events in the CNS. G W KreutzbergTrends Neurosci19968843599No
448105383512.7257.3485.8Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Da Wei Huang, Brad T Sherman, Richard A LempickiNucleic Acids Res200919033363Yes
44970253512.5146.5373.3A new method for sequencing DNA. A M Maxam, W GilbertProc Natl Acad Sci U S A1977265521Yes
45035113511.0161.22161.2Estimation of average heterozygosity and genetic distance from a small number of individuals. M NeiGenetics197817248844Yes
45135103510.073.3873.4Profile hidden Markov models. S R EddyBioinformatics19989918945No
45235053505.053.0853.1Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. J D RowleyNature19734126434Yes
453175233504.6495.6699.1Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. O P Hamill, A Marty, E Neher, B Sakmann, F J SigworthPflugers Arch19816270629Yes
45435003500.055.1455.1Spectroscopic determination of tryptophan and tyrosine in proteins. H EdelhochBiochemistry19676049437Yes
45535003500.079.779.7Nonalcoholic fatty liver disease. Paul AnguloN Engl J Med200211961152No
45634993499.080.1580.2Glutamate uptake. N C DanboltProg Neurobiol200111369436No
45769963498.0126.6763.3Translating the histone code. T Jenuwein, C D AllisScience200111498575No
45834943494.058.8858.9Statistical estimations in enzyme kinetics. G N WilkinsonBiochem J196113785321Yes
45934913491.081.4281.4The dendritic cell system and its role in immunogenicity. R M SteinmanAnnu Rev Immunol19911910679No
46034863486.0104.26104.3Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. L R SquirePsychol Rev19921594723No
46134753475.0111.71111.7Modeling valuations for EuroQol health states. P DolanMed Care19979366889Yes
46234743474.051.8951.9The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. J F WoessnerArch Biochem Biophys196113786180Yes
46334733473.085.2885.3The heat-shock response. S LindquistAnnu Rev Biochem19862427013No
46434723472.0100.75100.8Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Peter C AustinStat Med200919757444Yes
46534723472.093.7393.7A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. Heng LiBioinformatics201121903627Yes
46669263463.082.4341.2Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. D H Hubel, T N WieselJ Physiol196214449617Yes
467103723457.3400.46133.5Cancer statistics, 2013. Rebecca Siegel, Deepa Naishadham, Ahmedin JemalCA Cancer J Clin201323335087Yes
46834553455.0135.06135.1Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. O W GriffithAnal Biochem19807416462Yes
46934543454.095.7595.8Non-coding RNAs in human disease. Manel EstellerNat Rev Genet201122094949No
47034483448.082.982.9Neural networks and physical systems with emergent collective computational abilities. J J HopfieldProc Natl Acad Sci U S A19826953413Yes
47168783439.0162.7881.4"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. A P Feinberg, B VogelsteinAnal Biochem19846329026Yes
47234233423.093.5393.5Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. R W MahleyScience19883283935No
47368423421.0174.1487.1TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. T R Mosmann, R L CoffmanAnnu Rev Immunol19892523712No
47434213421.096.4596.5Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. Thomas WeltonChem Rev199911849019Yes
47534213421.0105.8105.8Health promotion by social cognitive means. Albert BanduraHealth Educ Behav200415090118Yes
47634193419.084.7984.8How do you feel? Interoception: the sense of the physiological condition of the body. A D CraigNat Rev Neurosci200212154366No
47734193419.0100.81100.8Accelerated Profile HMM Searches. Sean R EddyPLoS Comput Biol201122039361Yes
47834183418.074.4674.5Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. H F DvorakN Engl J Med19863537791No
479102353411.7464.64154.9Cancer statistics, 2015. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201525559415Yes
48034103410.085.4185.4The pathobiology of diabetic complications: a unifying mechanism. Michael BrownleeDiabetes200515919781No
48134033403.087.6987.7RELION: implementation of a Bayesian approach to cryo-EM structure determination. Sjors H W ScheresJ Struct Biol201223000701Yes
48234023402.00.00.0Some factors in the interpretation of protein denaturation. W KauzmannAdv Protein Chem195914404936Yes
48333963396.00.00.0The magical number seven plus or minus two: some limits on our capacity for processing information. G A MillerPsychol Rev195613310704Yes
48433893389.085.6185.6Biologic basis for interleukin-1 in disease. C A DinarelloBlood19968630372No
485101663388.771.1423.7The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. F C Greenwood, W M Hunter, J S GloverBiochem J196314097352Yes
48633683368.077.1777.2Tolerance, danger, and the extended family. P MatzingerAnnu Rev Immunol19948011301No
487100943364.7366.2122.1Cancer statistics, 2012. Rebecca Siegel, Deepa Naishadham, Ahmedin JemalCA Cancer J Clin201222237781Yes
488100923364.0251.9284.0Understanding the Warburg effect: the metabolic requirements of cell proliferation. Matthew G Vander Heiden, Lewis C Cantley, Craig B ThompsonScience200919460998No
48967163358.0133.5366.8Statistical significance for genomewide studies. John D Storey, Robert TibshiraniProc Natl Acad Sci U S A200312883005Yes
49033573357.0103.78103.8Psychometric properties of the strengths and difficulties questionnaire. R GoodmanJ Am Acad Child Adolesc Psychiatry200111699809Yes
491134233355.8432.51108.1A brief measure for assessing generalized anxiety disorder: the GAD-7. Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd LöweArch Intern Med200616717171Yes
49233493349.068.4868.5The scanning model for translation: an update. M KozakJ Cell Biol19892645293No
49366893344.5184.7592.4Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Daniel R Zerbino, Ewan BirneyGenome Res200818349386Yes
49433403340.081.6881.7The basis of anisotropic water diffusion in the nervous system - a technical review. Christian BeaulieuNMR Biomed200212489094No
49566753337.5169.8584.9Long short-term memory. S Hochreiter, J SchmidhuberNeural Comput19979377276Yes
49633323332.068.2168.2Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. M KozakNucleic Acids Res19846694911Yes
49733253325.0105.51105.5DNA methylation age of human tissues and cell types. Steve HorvathGenome Biol201324138928Yes
49866423321.0157.4478.7Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. C Tuerk, L GoldScience19902200121Yes
49933203320.083.9684.0Gene regulation by steroid hormones. M BeatoCell19892644044No
50033193319.0122.52122.5You want to measure coping but your protocol's too long: consider the brief COPE. C S CarverInt J Behav Med199716250744Yes
50166373318.5127.1763.6The ubiquitin system. A Hershko, A CiechanoverAnnu Rev Biochem19989759494No
50266353317.5142.1671.1Angiogenesis in cancer and other diseases. P Carmeliet, R K JainNature200011001068No
50333123312.0106.48106.5Equilibrium Ultracentrifugation Of Dilute Solutions. D A YphantisBiochemistry196414155091Yes
50433053305.0148.41148.4The quality of care. How can it be assessed? A DonabedianJAMA19883045356No
50533003300.080.0480.0Wound healing--aiming for perfect skin regeneration. P MartinScience19979082989No
506130903272.5302.575.6Improved methods for building protein models in electron density maps and the location of errors in these models. T A Jones, J Y Zou, S W Cowan, M KjeldgaardActa Crystallogr A19912025413Yes
50732723272.088.9188.9Hay fever, hygiene, and household size. D P StrachanBMJ19892513902Yes
50832673267.087.0987.1ABC transporters: from microorganisms to man. C F HigginsAnnu Rev Cell Biol19921282354No
50965223261.0204.13102.1Human malaria parasites in continuous culture. W Trager, J B JensenScience1976781840Yes
51032533253.063.963.9The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Isaiah J FidlerNat Rev Cancer200312778135No
51132503250.093.4593.5Inositol trisphosphate and diacylglycerol: two interacting second messengers. M J BerridgeAnnu Rev Biochem19873304132No
51232443244.060.0360.0Cell signaling by receptor tyrosine kinases. J SchlessingerCell200011057895No
51332413241.066.6666.7Alzheimer's disease is a synaptic failure. Dennis J SelkoeScience200212399581No
51432393239.069.9970.0Activators and target genes of Rel/NF-kappaB transcription factors. H L PahlOncogene199910602461No
51532353235.076.1176.1Photoelectrochemical cells. M GrätzelNature200111713540Yes
51632343234.063.9664.0STATs and gene regulation. J E DarnellScience19979287210No
51732233223.0103.25103.2No adjustments are needed for multiple comparisons. K J RothmanEpidemiology19902081237Yes
51864323216.0218.17109.1Management of hepatocellular carcinoma: an update. Jordi Bruix, Morris ShermanHepatology201121374666No
51932133213.079.4679.5The transforming growth factor-beta family. J MassaguéAnnu Rev Cell Biol19902177343No
52032013201.065.6765.7CpG-rich islands and the function of DNA methylation. A P BirdNature19862423876No
52164003200.0200.23100.1Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. C Beauchamp, I FridovichAnal Biochem19714943714Yes
52231983198.073.0673.1Mitochondrial formation of reactive oxygen species. Julio F TurrensJ Physiol200314561818No
52331923192.0111.32111.3Transformed up-down methods in psychoacoustics. H LevittJ Acoust Soc Am19715541744Yes
52431913191.096.6696.7Development of a classification system for periodontal diseases and conditions. G C ArmitageAnn Periodontol199910863370No
52531913191.067.0167.0Protein folding and misfolding. Christopher M DobsonNature200314685248No
526159423188.41166.16233.2MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro TamuraMol Biol Evol201829722887Yes
52763663183.0174.2887.1Projections of global mortality and burden of disease from 2002 to 2030. Colin D Mathers, Dejan LoncarPLoS Med200617132052Yes
52831803180.094.8694.9adegenet: a R package for the multivariate analysis of genetic markers. Thibaut JombartBioinformatics200818397895Yes
52931693169.0102.01102.0Essential oils: their antibacterial properties and potential applications in foods--a review. Sara BurtInt J Food Microbiol200415246235No
53031523152.066.7266.7Cardiac excitation-contraction coupling. Donald M BersNature200211805843No
53163033151.5199.5599.8Complex network measures of brain connectivity: uses and interpretations. Mikail Rubinov, Olaf SpornsNeuroimage201019819337Yes
53231413141.074.0274.0WHAT IF: a molecular modeling and drug design program. G VriendJ Mol Graph19902268628Yes
53362703135.0132.9866.5Toll-like receptor signalling. Shizuo Akira, Kiyoshi TakedaNat Rev Immunol200415229469No
53462613130.5196.3998.2The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Stephen B Edge, Carolyn C ComptonAnn Surg Oncol201020180029No
53531293129.00.00.0Diffusion-in-gel methods for immunological analysis. O OuchterlonyProg Allergy195813578996Yes
53631283128.066.4166.4Mechanisms of angiogenesis and arteriogenesis. P CarmelietNat Med200010742145No
53731223122.027.2127.2Gene action in the X-chromosome of the mouse (Mus musculus L.). M F LyonNature196113764598Yes
53831153115.065.9265.9Angiogenesis in health and disease. Peter CarmelietNat Med200312778163No
53931113111.095.8895.9Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Sarah E BarlowPediatrics200718055651Yes
54031043104.088.9188.9Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. Y X FuGenetics19979335623Yes
54192983099.3313.05104.4Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. R M Palmer, A G Ferrige, S MoncadaNature19873495737Yes
54261973098.5100.7250.4Pain mechanisms: a new theory. R Melzack, P D WallScience19655320816No
54361953097.5150.9775.5In vitro selection of RNA molecules that bind specific ligands. A D Ellington, J W SzostakNature19901697402Yes
54461903095.0203.36101.7Measuring agreement in method comparison studies. J M Bland, D G AltmanStat Methods Med Res199910501650No
54530913091.0119.39119.4Half a century of research on the Stroop effect: an integrative review. C M MacLeodPsychol Bull19912034749No
54630873087.085.8385.8Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. S W KesslerJ Immunol19751102604Yes
54792583086.0193.7764.6Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Benjamin P Lewis, Christopher B Burge, David P BartelCell200515652477Yes
54830853085.076.2476.2Recent advances with liposomes as pharmaceutical carriers. Vladimir P TorchilinNat Rev Drug Discov200515688077No
54961623081.0181.4390.7Complex brain networks: graph theoretical analysis of structural and functional systems. Ed Bullmore, Olaf SpornsNat Rev Neurosci200919190637No
55061553077.5148.6174.3Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Weizhong Li, Adam GodzikBioinformatics200616731699Yes
551123063076.5468.48117.1APACHE II: a severity of disease classification system. W A Knaus, E A Draper, D P Wagner, J E ZimmermanCrit Care Med19853928249Yes
55261523076.0150.2475.1Exploring the full spectrum of macrophage activation. David M Mosser, Justin P EdwardsNat Rev Immunol200819029990No
55361503075.0155.6177.8Voxel-based morphometry--the methods. J Ashburner, K J FristonNeuroimage200010860804No
55430663066.072.7572.8Obesity as a medical problem. P G KopelmanNature200010766250No
55561203060.0136.2868.1MicroRNA signatures in human cancers. George A Calin, Carlo M CroceNat Rev Cancer200617060945No
55661153057.553.1826.6The serial cultivation of human diploid cell strains. L Hayflick, P S MoorheadExp Cell Res196113905658Yes
55791693056.3258.7586.2Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. G Evanno, S Regnaut, J GoudetMol Ecol200515969739Yes
55830493049.053.753.7Automated electron microscope tomography using robust prediction of specimen movements. David N MastronardeJ Struct Biol200516182563Yes
55930493049.0107.8107.8The Danish Civil Registration System. Carsten Bøcker PedersenScand J Public Health201121775345Yes
56030493049.089.2789.3Hepatocellular carcinoma. Hashem B El-SeragN Engl J Med201121992124No
56130473047.070.7570.8Cadherin cell adhesion receptors as a morphogenetic regulator. M TakeichiScience19912006419No
56230453045.0104.74104.7The processing-speed theory of adult age differences in cognition. T A SalthousePsychol Rev19968759042No
56360863043.0108.0754.0The language of covalent histone modifications. B D Strahl, C D AllisNature200010638745Yes
56430343034.0122.75122.8Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. T E MoffittPsychol Rev19938255953No
56560563028.0178.689.3Electrochemical photolysis of water at a semiconductor electrode. A Fujishima, K HondaNature197212635268Yes
56660503025.0161.8780.9The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Taro Kawai, Shizuo AkiraNat Immunol201020404851No
56730133013.00.00.0A study of fixation for electron microscopy. G E PaladeJ Exp Med195214927794Yes
56860193009.50.00.0A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. S Reitman, S FrankelAm J Clin Pathol195713458125Yes
56990283009.3177.859.3Significance analysis of microarrays applied to the ionizing radiation response. V G Tusher, R Tibshirani, G ChuProc Natl Acad Sci U S A200111309499Yes
57060163008.0187.093.5Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. K Tamura, M NeiMol Biol Evol19938336541Yes
57130083008.076.0576.0Cellular and molecular mechanisms of fibrosis. T A WynnJ Pathol200818161745No
57260163008.0180.390.2mTOR signaling in growth control and disease. Mathieu Laplante, David M SabatiniCell201222500797No
57330043004.0108.59108.6A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. S HakomoriJ Biochem196414135466Yes
57429992999.072.8872.9The resurgence of platinum-based cancer chemotherapy. Lloyd KellandNat Rev Cancer200717625587No
57529962996.064.6464.6TGFbeta in Cancer. Joan MassaguéCell200818662538No
57629952995.079.2779.3Accurate Coulomb-fitting basis sets for H to Rn. Florian WeigendPhys Chem Chem Phys200616633586Yes
57729942994.095.0895.1An empirical correction for absorption anisotropy. R H BlessingActa Crystallogr A19957702794Yes
57829942994.00.00.0Catheter replacement of the needle in percutaneous arteriography; a new technique. S I SeldingerActa radiol195313057644Yes
57929882988.0107.26107.3Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. Joseph P WeirJ Strength Cond Res200515705040No
58059622981.0250.24125.1Assessment of outcome after severe brain damage. B Jennett, M BondLancet197546957Yes
58129812981.0101.94101.9Measurement of pain. E C HuskissonLancet19744139420Yes
58229802980.069.0169.0Chemokines--chemotactic cytokines that mediate inflammation. A D LusterN Engl J Med19989459648No
58329782978.052.7552.8The gel-filtration behaviour of proteins related to their molecular weights over a wide range. P AndrewsBiochem J19655862401Yes
584118992974.8282.0870.5Haploview: analysis and visualization of LD and haplotype maps. J C Barrett, B Fry, J Maller, M J DalyBioinformatics200515297300Yes
58559492974.5125.5662.8Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. D B Smith, K S JohnsonGene19883047011Yes
58629742974.055.9155.9Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. P SchuckBiophys J200010692345Yes
587237882973.5518.5764.8The Protein Data Bank. H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E BourneNucleic Acids Res200010592235Yes
58859422971.0141.0370.5Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. T C Chou, P TalalayAdv Enzyme Regul19846382953Yes
58929642964.0134.39134.4The short-form McGill Pain Questionnaire. Ronald MelzackPain19873670870Yes
59059262963.0134.0767.0Oxidants, oxidative stress and the biology of ageing. T Finkel, N J HolbrookNature200011089981No
59129612961.058.6158.6Toll-like receptors and innate immunity. R MedzhitovNat Rev Immunol200111905821No
59288762958.7207.0869.0TopHat: discovering splice junctions with RNA-Seq. Cole Trapnell, Lior Pachter, Steven L SalzbergBioinformatics200919289445Yes
59329532953.054.8454.8RNA interference. Gregory J HannonNature200212110901No
59429502950.090.8690.9Matrix metalloproteinases and their inhibitors in connective tissue remodeling. J F WoessnerFASEB J19911850705No
59529482948.0101.48101.5What is value in health care? Michael E PorterN Engl J Med201021142528Yes
59688402946.7242.5580.9Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Y Gavrieli, Y Sherman, S A Ben-SassonJ Cell Biol19921400587Yes
59758772938.5184.4292.2Tissue engineering. R Langer, J P VacantiScience19938493529No
59829322932.073.2273.2Optimal two-stage designs for phase II clinical trials. R SimonControl Clin Trials19892702835Yes
59958642932.0124.6962.3Emergence of scaling in random networks A L Barabasi, R AlbertScience199910521342Yes
60029282928.079.8379.8The nuclear factor NF-kappaB pathway in inflammation. Toby LawrenceCold Spring Harb Perspect Biol200920457564No
601263422926.9566.5863.0Cytoscape: a software environment for integrated models of biomolecular interaction networks. Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey IdekerGenome Res200314597658Yes
60258422921.0174.8887.4The fluid mosaic model of the structure of cell membranes. S J Singer, G L NicolsonScience19724333397Yes
60387522917.3285.8295.3Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. R A Deyo, D C Cherkin, M A CiolJ Clin Epidemiol19921607900Yes
60458102905.0162.8481.4Inositol trisphosphate, a novel second messenger in cellular signal transduction. M J Berridge, R F IrvineNature19846095092No
60529002900.088.3988.4Estimation of metabolite concentrations from localized in vivo proton NMR spectra. S W ProvencherMagn Reson Med19938139448Yes
60628962896.065.5565.5Autophagy: process and function. Noboru MizushimaGenes Dev200718006683No
60786822894.00.00.0The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. R J Havel, H A Eder, J H BragdonJ Clin Invest195513252080Yes
60828922892.051.6451.6One-step gene disruption in yeast. R J RothsteinMethods Enzymol19836310324Yes
60928912891.060.1760.2Principles of CDK regulation. D O MorganNature19957877684No
61028892889.00.00.0The genetical structure of populations. S WrightAnn Eugen195124540312Yes
61128872887.070.2770.3Phase separation of integral membrane proteins in Triton X-114 solution. C BordierJ Biol Chem19816257680Yes
61228832883.086.586.5Implications of normal brain development for the pathogenesis of schizophrenia. D R WeinbergerArch Gen Psychiatry19873606332Yes
613115302882.5423.43105.9Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg LangBehav Res Methods200919897823Yes
61486352878.3213.4871.2ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Kai Wang, Mingyao Li, Hakon HakonarsonNucleic Acids Res201020601685Yes
61528762876.068.6368.6Structure and function of telomeres. E H BlackburnNature19911708110No
61628762876.00.00.0Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. L SvennerholmBiochim Biophys Acta195713436486Yes
61786232874.3198.1766.1The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. R C Lee, R L Feinbaum, V AmbrosCell19938252621Yes
61886152871.7163.5354.5Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Ron Edgar, Michael Domrachev, Alex E LashNucleic Acids Res200211752295Yes
61957432871.5250.88125.4GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. Rod Peakall, Peter E SmouseBioinformatics201222820204Yes
62028692869.096.196.1Stereotaxic mapping of the monoamine pathways in the rat brain. U UngerstedtActa Physiol Scand Suppl19714109331Yes
62128682868.061.8961.9Inflammatory bowel disease. Daniel K PodolskyN Engl J Med200212167685No
62257332866.5126.7363.4Oncomirs - microRNAs with a role in cancer. Aurora Esquela-Kerscher, Frank J SlackNat Rev Cancer200616557279No
62328652865.029.2929.3Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. P MitchellNature196113771349Yes
62428632863.095.2195.2Role of oxidative stress in development of complications in diabetes. J W BaynesDiabetes19912010041No
62528622862.094.1694.2Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. B E MurphyJ Clin Endocrinol Metab19674291524Yes
62628622862.050.4850.5A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. E A GehanBiometrika196514341275Yes
62728622862.00.00.0A study of the adrenotropic receptors. R P AhlquistAm J Physiol194818882199Yes
62885752858.3256.4385.5Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. G Fairbanks, T L Steck, D F WallachBiochemistry19714326772Yes
62928582858.099.9499.9Measures of reliability in sports medicine and science. W G HopkinsSports Med200010907753Yes
63057102855.0145.7372.9Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Glowinski, L L IversenJ Neurochem19665950056Yes
63128552855.00.00.0Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. W C SchneiderJ Biol Chem194521005736Yes
63228542854.052.6952.7Genome maintenance mechanisms for preventing cancer. J H HoeijmakersNature200111357144No
63328492849.082.4582.5Efficient methods to compute genomic predictions. P M VanRadenJ Dairy Sci200818946147Yes
63456962848.0119.6859.8Inflammation and cancer: back to Virchow? F Balkwill, A MantovaniLancet200111229684No
63556772838.5247.35123.7Revised methods for the Salmonella mutagenicity test. D M Maron, B N AmesMutat Res19836341825Yes
63628382838.00.00.0Notes on sugar determination. M SmogyiJ Biol Chem195214938350Yes
63728372837.046.4746.5A Rationale And Test For The Number Of Factors In Factor Analysis. J L HornPsychometrika196514306381Yes
63856742837.0149.3574.7Pattern recognition receptors and inflammation. Osamu Takeuchi, Shizuo AkiraCell201020303872No
63928342834.042.9743.0Towards a network theory of the immune system. N K JerneAnn Immunol (Paris)19744142565No
64028322832.064.3164.3Calcium signaling. David E ClaphamCell200718083096No
64128292829.054.8454.8A gene complex controlling segmentation in Drosophila. E B LewisNature1978103000Yes
64228282828.066.7366.7MapChart: software for the graphical presentation of linkage maps and QTLs. R E VoorripsJ Hered200212011185Yes
64356432821.5149.3174.7Unified segmentation. John Ashburner, Karl J FristonNeuroimage200515955494Yes
64456392819.5178.8489.4Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. R M Ryan, E L DeciAm Psychol200011392867Yes
64528152815.060.7460.7Nuclear factor-kappaB in cancer development and progression. Michael KarinNature200616724054No
646112572814.2332.1583.0Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Qiong Wang, George M Garrity, James M Tiedje, James R ColeAppl Environ Microbiol200717586664Yes
64728082808.065.7365.7Modularity and community structure in networks. M E J NewmanProc Natl Acad Sci U S A200616723398Yes
64828072807.052.3452.3Elastic properties of lipid bilayers: theory and possible experiments. W HelfrichZ Naturforsch C19734273690Yes
64956132806.5208.0104.0The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. P F Lovibond, S H LovibondBehav Res Ther19957726811Yes
65028052805.069.2169.2Analysis of gene diversity in subdivided populations. M NeiProc Natl Acad Sci U S A19734519626Yes
65156012800.5152.4776.2The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. J Vieira, J MessingGene19826295879Yes
65227992799.055.4755.5Papillomaviruses and cancer: from basic studies to clinical application. Harald zur HausenNat Rev Cancer200212044010No
65327992799.055.2955.3Interleukin-12 and the regulation of innate resistance and adaptive immunity. Giorgio TrinchieriNat Rev Immunol200312563297No
65455942797.0126.6963.3Caspases: enemies within. N A Thornberry, Y LazebnikScience19989721091No
65527962796.084.8784.9Primate models of movement disorders of basal ganglia origin. M R DeLongTrends Neurosci19901695404No
65683862795.3429.04143.0Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. P J Van Soest, J B Robertson, B A LewisJ Dairy Sci19911660498No
65727912791.0113.45113.5Microplastics in the marine environment. Anthony L AndradyMar Pollut Bull201121742351No
65827882788.065.2765.3Molecular chaperones in cellular protein folding. F U HartlNature19968637592No
65927872787.00.00.0Efficient trace-labelling of proteins with iodine. A S McFARLANENature195813566175Yes
66055742787.077.5938.8A method for determining the sedimentation behavior of enzymes: application to protein mixtures. R G Martin, B N AmesJ Biol Chem196113767412Yes
661111422785.5297.874.5Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. P W Rigby, M Dieckmann, C Rhodes, P BergJ Mol Biol1977881736Yes
66255712785.5112.356.1Establishment in culture of pluripotential cells from mouse embryos. M J Evans, M H KaufmanNature19817242681Yes
66355702785.0172.9186.5Computed tomography--an increasing source of radiation exposure. David J Brenner, Eric J HallN Engl J Med200718046031No
66455682784.0133.6866.8Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. S Marklund, G MarklundEur J Biochem19744215654Yes
66555672783.5192.5896.3A method of comparing the areas under receiver operating characteristic curves derived from the same cases. J A Hanley, B J McNeilRadiology19836878708Yes
66627812781.047.5347.5Mechanisms underlying ubiquitination. C M PickartAnnu Rev Biochem200111395416No
66727802780.0116.03116.0Colorimetric assay of catalase. A K SinhaAnal Biochem19724556490Yes
66855532776.5165.7982.9Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. J Sedlak, R H LindsayAnal Biochem19684973948Yes
669110842771.0341.7785.4Cancer statistics, 2010. Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth WardCA Cancer J Clin201020610543Yes
67082782759.3189.1563.1Pathogen recognition and innate immunity. Shizuo Akira, Satoshi Uematsu, Osamu TakeuchiCell200616497588No
67127592759.061.6161.6Salt and drought stress signal transduction in plants. Jian-Kang ZhuAnnu Rev Plant Biol200212221975No
67227572757.0105.38105.4A simple technique for demonstrating centromeric heterochromatin. A T SumnerExp Cell Res19724117921Yes
67355132756.5109.6154.8Innate immune recognition. Charles A Janeway, Ruslan MedzhitovAnnu Rev Immunol200211861602No
67455112755.5133.8166.9Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. D Hanahan, J FolkmanCell19968756718No
67527552755.066.4166.4Cell death during development of the nervous system. R W OppenheimAnnu Rev Neurosci19912031577No
67627542754.0124.58124.6Detecting alcoholism. The CAGE questionnaire. J A EwingJAMA19846471323Yes
67755052752.590.9345.5A modified uronic acid carbazole reaction. T Bitter, H M MuirAnal Biochem196213971270Yes
67854972748.5129.8864.9Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. F W Studier, B A MoffattJ Mol Biol19863537305Yes
67927412741.068.5168.5Models for the specific adhesion of cells to cells. G I BellScience1978347575No
68054712735.5167.1783.6Glutathione. A Meister, M E AndersonAnnu Rev Biochem19836137189No
68154512725.5197.4198.7Longitudinal data analysis for discrete and continuous outcomes. S L Zeger, K Y LiangBiometrics19863719049Yes
68227252725.070.3970.4Predictive reward signal of dopamine neurons. W SchultzJ Neurophysiol19989658025No
68327232723.069.0869.1The genetic legacy of the Quaternary ice ages. G HewittNature200010879524No
68427202720.053.1653.2The danger model: a renewed sense of self. Polly MatzingerScience200211951032Yes
685298902717.3623.0356.6Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P MesirovProc Natl Acad Sci U S A200516199517Yes
68681502716.7352.43117.5Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. J L Cox, J M Holden, R SagovskyBr J Psychiatry19873651732Yes
68754332716.5107.6453.8High-efficiency transformation of mammalian cells by plasmid DNA. C Chen, H OkayamaMol Cell Biol19873670292Yes
68854292714.5127.0963.5Autophagy in the pathogenesis of disease. Beth Levine, Guido KroemerCell200818191218No
68927132713.061.461.4Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. S A BustinJ Mol Endocrinol200011013345No
69081372712.3175.1458.4Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. C M Gorman, L F Moffat, B H HowardMol Cell Biol19826960240Yes
69154172708.5149.7874.9Adherence to medication. Lars Osterberg, Terrence BlaschkeN Engl J Med200516079372No
69254082704.0168.7284.4Accurate and simple analytic representation of the electron-gas correlation energy. J P Perdew, Y WangPhys Rev B Condens Matter199210001404Yes
69327042704.058.5658.6Bone resorption by osteoclasts. S L TeitelbaumScience200010968780No
69427042704.068.3168.3Dietary pattern analysis: a new direction in nutritional epidemiology. Frank B HuCurr Opin Lipidol200211790957No
69527002700.062.8362.8Memory--a century of consolidation. J L McGaughScience200010634773No
69680862695.3200.8667.0MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Sudhir Kumar, Koichiro Tamura, Masatoshi NeiBrief Bioinform200415260895Yes
69726932693.0102.92102.9Role of nrf2 in oxidative stress and toxicity. Qiang MaAnnu Rev Pharmacol Toxicol201323294312No
69880772692.3200.166.7Canonical sampling through velocity rescaling. Giovanni Bussi, Davide Donadio, Michele ParrinelloJ Chem Phys200717212484Yes
69926902690.060.6260.6Cell adhesion: the molecular basis of tissue architecture and morphogenesis. B M GumbinerCell19968608588No
70026902690.077.5777.6Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). Gunther EysenbachJ Med Internet Res200415471760No
70126872687.060.560.5Prostaglandins and leukotrienes: advances in eicosanoid biology. C D FunkScience200111729303No
70226872687.0101.41101.4KDIGO clinical practice guidelines for acute kidney injury. Arif KhwajaNephron Clin Pract201222890468No
70353662683.0153.9277.0The Social Readjustment Rating Scale. T H Holmes, R H RaheJ Psychosom Res19676059863Yes
704107292682.2227.6756.9Cluster analysis and display of genome-wide expression patterns. M B Eisen, P T Spellman, P O Brown, D BotsteinProc Natl Acad Sci U S A19989843981Yes
70526772677.075.875.8Parkinson's disease: clinical features and diagnosis. J JankovicJ Neurol Neurosurg Psychiatry200818344392No
70653382669.0255.82127.9Stress, social support, and the buffering hypothesis. S Cohen, T A WillsPsychol Bull19853901065No
70753352667.5157.4978.7Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. Jeng-Da Chai, Martin Head-GordonPhys Chem Chem Phys200818989472Yes
70826662666.080.5580.5SF-36 health survey update. J E WareSpine (Phila Pa 1976)200011124729No
709106532663.2314.8778.7Establishing a standard definition for child overweight and obesity worldwide: international survey. T J Cole, M C Bellizzi, K M Flegal, W H DietzBMJ200010797032Yes
71026602660.051.5851.6Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Shimon SakaguchiAnnu Rev Immunol200415032588No
71126512651.068.5968.6Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. P CuatrecasasJ Biol Chem19705432796Yes
71226512651.023.3223.3Satellite cell of skeletal muscle fibers. A MauroJ Biophys Biochem Cytol196113768451Yes
71326492649.069.8969.9The magical number 4 in short-term memory: a reconsideration of mental storage capacity. N CowanBehav Brain Sci200111515286Yes
714185312647.3710.57101.5limma powers differential expression analyses for RNA-sequencing and microarray studies. Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K SmythNucleic Acids Res201525605792Yes
71526432643.057.657.6On the number of segregating sites in genetical models without recombination. G A WattersonTheor Popul Biol19751145509Yes
716237672640.8761.6484.6STAR: ultrafast universal RNA-seq aligner. Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R GingerasBioinformatics201323104886Yes
71752802640.0181.0290.5The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. S H Downs, N BlackJ Epidemiol Community Health19989764259Yes
71826392639.060.3260.3Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. G P SmithScience19854001944Yes
71926362636.065.8265.8The nerve growth factor 35 years later. R Levi-MontalciniScience19873306916No
72026342634.081.7581.8What are the functional consequences of neurocognitive deficits in schizophrenia? M F GreenAm J Psychiatry19968610818No
72126312631.081.9281.9Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. B SamuelssonScience19836301011Yes
72252602630.00.00.0Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. J D Watson, F H CrickNature195313054692Yes
72326282628.063.5363.5T cell exhaustion. E John WherryNat Immunol201121739672No
72452532626.5136.7268.4Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. L A Greene, A S TischlerProc Natl Acad Sci U S A19761065897Yes
72552532626.5181.7990.9Extracellular vesicles: exosomes, microvesicles, and friends. Graça Raposo, Willem StoorvogelJ Cell Biol201323420871No
72626222622.0104.97105.0The biology of oxygen radicals. I FridovichScience1978210504Yes
72752412620.5207.87103.9A feature-integration theory of attention. A M Treisman, G GeladeCogn Psychol19807351125Yes
72852402620.0117.2458.6Signal transduction by receptors with tyrosine kinase activity. A Ullrich, J SchlessingerCell19902158859No
72926162616.077.777.7The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Claudio HetzNat Rev Mol Cell Biol201222251901No
73026142614.059.1359.1Vascular endothelial growth factor: basic science and clinical progress. Napoleone FerraraEndocr Rev200415294883No
73152272613.50.00.0Some quantitative uses of drug antagonists. O Arunlakshana, H O SchildBr J Pharmacol Chemother195913651579Yes
73252212610.5180.6990.3A simple, rapid, and sensitive DNA assay procedure. C Labarca, K PaigenAnal Biochem19806158890Yes
73326082608.063.4263.4Molecular basis of bacterial outer membrane permeability revisited. Hiroshi NikaidoMicrobiol Mol Biol Rev200314665678No
73426052605.0115.18115.2The membrane actions of anesthetics and tranquilizers. P SeemanPharmacol Rev19724565956No
73526042604.074.574.5Formation and Structure of Self-Assembled Monolayers. Abraham UlmanChem Rev199611848802Yes
73625982598.055.7155.7G1 phase progression: cycling on cue. C J SherrCell19947954821No
73751892594.5106.8653.4MicroRNAs: small RNAs with a big role in gene regulation. Lin He, Gregory J HannonNat Rev Genet200415211354No
73851832591.5158.5479.3Rapid isolation of high molecular weight plant DNA. M G Murray, W F ThompsonNucleic Acids Res19807433111Yes
73951802590.0101.3750.7Untangling the ErbB signalling network. Y Yarden, M X SliwkowskiNat Rev Mol Cell Biol200111252954No
74025892589.062.362.3Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. E C ButcherCell19911760836No
74125892589.062.6362.6Cancer nanotechnology: opportunities and challenges. Mauro FerrariNat Rev Cancer200515738981No
742155162586.0348.4258.1Phaser crystallographic software. Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J ReadJ Appl Crystallogr200719461840Yes
74325822582.00.00.0The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. R R PorterBiochem J195914434282Yes
74425782578.057.0557.0Epigenetics in cancer. Manel EstellerN Engl J Med200818337604No
74551552577.5159.6479.8The L-arginine-nitric oxide pathway. S Moncada, A HiggsN Engl J Med19937504210No
74625762576.073.1573.2Delayed neuronal death in the gerbil hippocampus following ischemia. T KirinoBrain Res19827093691Yes
74751412570.5166.9283.5The neural basis of drug craving: an incentive-sensitization theory of addiction. T E Robinson, K C BerridgeBrain Res Brain Res Rev19938401595No
74825652565.036.536.5The catecholamine hypothesis of affective disorders: a review of supporting evidence. J J SchildkrautAm J Psychiatry19655319766No
74925642564.068.3968.4Dominant forces in protein folding. K A DillBiochemistry19902207096No
75025612561.00.00.0Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. O SmithiesBiochem J195513276348Yes
75176822560.7264.5688.2Effect of the damping function in dispersion corrected density functional theory. Stefan Grimme, Stephan Ehrlich, Lars GoerigkJ Comput Chem201121370243Yes
75225602560.050.3450.3Tumour-educated macrophages promote tumour progression and metastasis. Jeffrey W PollardNat Rev Cancer200414708027No
75351182559.081.0240.5A general method applicable to the search for similarities in the amino acid sequence of two proteins. S B Needleman, C D WunschJ Mol Biol19705420325Yes
75425592559.00.00.0The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. M L AnsonJ Gen Physiol193819873094Yes
75525582558.0103.72103.7Qualitative research. Introducing focus groups. J KitzingerBMJ19957633241Yes
75625572557.053.3553.4Evolving concepts of rheumatoid arthritis. Gary S FiresteinNature200312748655No
75725432543.028.3828.4The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. S BoydenJ Exp Med196213872176Yes
75825422542.0100.57100.6Central sensitization: implications for the diagnosis and treatment of pain. Clifford J WoolfPain201120961685No
75950782539.0235.98118.0Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. J Silness, H LoeActa Odontol Scand196414158464Yes
76025362536.072.7872.8Stress, adaptation, and disease. Allostasis and allostatic load. B S McEwenAnn N Y Acad Sci19989629234No
76125342534.050.9551.0Universal control mechanism regulating onset of M-phase. P NurseNature19902138713No
76225322532.082.5582.5Perceived exertion as an indicator of somatic stress. G BorgScand J Rehabil Med19705523831Yes
76325312531.051.8151.8Telomere measurement by quantitative PCR. Richard M CawthonNucleic Acids Res200212000852Yes
76450602530.0274.14137.1A diagnostic interview: the schedule for affective disorders and schizophrenia. J Endicott, R L SpitzerArch Gen Psychiatry1978678037Yes
76525302530.077.7377.7Secretory products of macrophages. C F NathanJ Clin Invest19873543052No
76625302530.055.0355.0Angiogenesis in life, disease and medicine. Peter CarmelietNature200516355210No
76775772525.7225.5275.2FastTree 2--approximately maximum-likelihood trees for large alignments. Morgan N Price, Paramvir S Dehal, Adam P ArkinPLoS One201020224823Yes
76850482524.0125.0762.5Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Klaus Apel, Heribert HirtAnnu Rev Plant Biol200415377225No
76925242524.070.3270.3Physiology and neurobiology of stress and adaptation: central role of the brain. Bruce S McEwenPhysiol Rev200717615391No
77025222522.070.870.8Two-sided confidence intervals for the single proportion: comparison of seven methods. R G NewcombeStat Med19989595616Yes
77125152515.061.7561.8A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Pascal FriesTrends Cogn Sci200516150631No
77225052505.086.8386.8A computational approach to edge detection. J CannyIEEE Trans Pattern Anal Mach Intell198621869365Yes
77349952497.5179.7889.9Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. P J Fraker, J C SpeckBiochem Biophys Res Commun1978637870Yes
77499892497.2454.61113.7IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang MinhMol Biol Evol201525371430Yes
77599892497.21532.53383.1Cancer Statistics, 2021. Rebecca L Siegel, Kimberly D Miller, Hannah E Fuchs, Ahmedin JemalCA Cancer J Clin202133433946Yes
77624962496.044.9845.0Wnt signaling and cancer. P PolakisGenes Dev200010921899No
77724962496.077.9678.0The free-energy principle: a unified brain theory? Karl FristonNat Rev Neurosci201020068583No
77824942494.069.7169.7Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. P CorreaCancer Res19921458460No
77999522488.0412.15103.0Cancer statistics, 2014. Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin JemalCA Cancer J Clin201424399786Yes
78024872487.0112.32112.3Oxygen-dependent microbial killing by phagocytes (first of two parts). B M BabiorN Engl J Med197824176Yes
78124872487.081.9381.9A rating instrument for anxiety disorders. W W ZungPsychosomatics19715172928Yes
78224842484.078.5278.5Social cognitive theory: an agentic perspective. A BanduraAnnu Rev Psychol200111148297Yes
78324832483.060.3160.3Separation of leukocytes from blood and bone marrow. Introduction. A BöyumScand J Clin Lab Invest Suppl19685707208Yes
78449612480.5141.4970.7Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. J V Durnin, J WomersleyBr J Nutr19744843734Yes
78524782478.066.1166.1Evaluating the quality of medical care. A DonabedianMilbank Mem Fund Q19665338568No
78674282476.0202.3767.5Quantum mechanical continuum solvation models. Jacopo Tomasi, Benedetta Mennucci, Roberto CammiChem Rev200516092826Yes
78749512475.5119.1459.6Calculation of protein extinction coefficients from amino acid sequence data. S C Gill, P H von HippelAnal Biochem19892610349Yes
78849492474.599.5149.8Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. D Bonnet, J E DickNat Med19979212098Yes
78949442472.096.3548.2CDK inhibitors: positive and negative regulators of G1-phase progression. C J Sherr, J M RobertsGenes Dev199910385618No
79024542454.054.4954.5Social controls on cell survival and cell death. M C RaffNature19921557121No
79173412447.0184.9561.6RNA-Seq: a revolutionary tool for transcriptomics. Zhong Wang, Mark Gerstein, Michael SnyderNat Rev Genet200919015660No
79224462446.047.3647.4Getting started with yeast. F ShermanMethods Enzymol19912005794Yes
79324462446.0105.31105.3Statistics corner: A guide to appropriate use of correlation coefficient in medical research. M M MukakaMalawi Med J201223638278Yes
79424442444.065.8965.9Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. H G GratznerScience19827123245Yes
79524442444.00.00.0Transduction of linked genetic characters of the host by bacteriophage P1. E S LennoxVirology195513267987Yes
79648822441.0113.9857.0Myeloid-derived suppressor cells as regulators of the immune system. Dmitry I Gabrilovich, Srinivas NagarajNat Rev Immunol200919197294No
79724402440.0147.04147.0Hepatocellular Carcinoma. Augusto VillanuevaN Engl J Med201930970190No
79848752437.5213.98107.0Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. N S Jacobson, P TruaxJ Consult Clin Psychol19912002127Yes
79948752437.5145.4172.7SPSS and SAS procedures for estimating indirect effects in simple mediation models. Kristopher J Preacher, Andrew F HayesBehav Res Methods Instrum Comput200415641418Yes
80097252431.2256.1264.0GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. Berk Hess, Carsten Kutzner, David van der Spoel, Erik LindahlJ Chem Theory Comput200826620784Yes
80172922430.7195.2865.1Immunity, inflammation, and cancer. Sergei I Grivennikov, Florian R Greten, Michael KarinCell201020303878No
80224262426.060.9961.0Immunological and inflammatory functions of the interleukin-1 family. Charles A DinarelloAnnu Rev Immunol200919302047No
80324242424.058.0758.1Causes and consequences of microRNA dysregulation in cancer. Carlo M CroceNat Rev Genet200919763153No
80424132413.092.6492.6Missing data analysis: making it work in the real world. John W GrahamAnnu Rev Psychol200918652544No
80572342411.3206.1668.7Bacterial biofilms: a common cause of persistent infections. J W Costerton, P S Stewart, E P GreenbergScience199910334980No
80648202410.0125.3162.7UniFrac: a new phylogenetic method for comparing microbial communities. Catherine Lozupone, Rob KnightAppl Environ Microbiol200516332807Yes
80748192409.5107.8353.9Signal integration in the endoplasmic reticulum unfolded protein response. David Ron, Peter WalterNat Rev Mol Cell Biol200717565364No
80848162408.0119.6859.8A global optimisation method for robust affine registration of brain images. M Jenkinson, S SmithMed Image Anal200111516708Yes
80948042402.093.1946.6The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Igor Vivanco, Charles L SawyersNat Rev Cancer200212094235No
81024002400.076.8776.9Plant products as antimicrobial agents. M M CowanClin Microbiol Rev199910515903No
81123992399.0119.67119.7Electroimmuno assay. C B LaurellScand J Clin Lab Invest Suppl19724114358Yes
81271972399.0186.2562.1Cortical surface-based analysis. I. Segmentation and surface reconstruction. A M Dale, B Fischl, M I SerenoNeuroimage19999931268Yes
81323982398.052.2152.2Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. T HunterCell19957834742No
81447842392.0119.8759.9The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Karen Bedard, Karl-Heinz KrausePhysiol Rev200717237347No
81523912391.082.9482.9Doxil®--the first FDA-approved nano-drug: lessons learned. Yechezkel BarenholzJ Control Release201222484195No
81647802390.094.4247.2Lipid rafts and signal transduction. K Simons, D ToomreNat Rev Mol Cell Biol200011413487No
81723892389.00.00.0The information capacity of the human motor system in controlling the amplitude of movement. P M FittsJ Exp Psychol195413174710Yes
81847782389.049.8124.9Periodontal Disease In Pregnancy. I. Prevalence And Severity. H Loe, J SilnessActa Odontol Scand196314121956Yes
81923852385.050.0950.1Cisplatin: mode of cytotoxic action and molecular basis of resistance. Zahid H SiddikOncogene200314576837No
82047662383.0127.0263.5Alzheimer's disease: the amyloid cascade hypothesis. J A Hardy, G A HigginsScience19921566067No
82123792379.0120.19120.2Conservation of resources. A new attempt at conceptualizing stress. S E HobfollAm Psychol19892648906No
82223792379.049.6149.6Molecular physiology of P2X receptors. R Alan NorthPhysiol Rev200212270951No
82323782378.060.2160.2Inferring the historical patterns of biological evolution. M PagelNature199910553904Yes
82423752375.093.9794.0The biology and function of fibroblasts in cancer. Raghu KalluriNat Rev Cancer201627550820No
82523742374.080.9681.0A rapid radiochemical method for the determination of choline acetyltransferase. F FonnumJ Neurochem19751113118Yes
82623692369.043.4143.4Java Treeview--extensible visualization of microarray data. Alok J SaldanhaBioinformatics200415180930Yes
82723672367.054.0754.1A decade of molecular biology of retinoic acid receptors. P ChambonFASEB J19968801176No
82823672367.067.3267.3Scaffolds in tissue engineering bone and cartilage. D W HutmacherBiomaterials200011071603Yes
82947332366.5120.0660.0Management of hepatocellular carcinoma. Jordi Bruix, Morris ShermanHepatology200516250051No
83023652365.0107.52107.5Structural Model Evaluation and Modification: An Interval Estimation Approach. J H SteigerMultivariate Behav Res199026794479Yes
83147292364.5151.3575.7Microenvironmental regulation of tumor progression and metastasis. Daniela F Quail, Johanna A JoyceNat Med201324202395No
83247282364.0140.6870.3Neural mechanisms of selective visual attention. R Desimone, J DuncanAnnu Rev Neurosci19957605061No
83347192359.5103.751.9Death receptors: signaling and modulation. A Ashkenazi, V M DixitScience19989721089No
83447122356.0154.4677.2Random-effects models for longitudinal data. N M Laird, J H WareBiometrics19827168798Yes
83523552355.057.3457.3The anatomy and taxonomy of protein structure. J S RichardsonAdv Protein Chem19817020376No
83623532353.0101.89101.9The Michigan alcoholism screening test: the quest for a new diagnostic instrument. M L SelzerAm J Psychiatry19715565851Yes
83723522352.072.4172.4The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. B L FredricksonAm Psychol200111315248Yes
83846992349.5103.9352.0Screening lambdagt recombinant clones by hybridization to single plaques in situ. W D Benton, R W DavisScience1977322279Yes
83946992349.5136.368.2Nonparametric statistical testing of EEG- and MEG-data. Eric Maris, Robert OostenveldJ Neurosci Methods200717517438Yes
84023492349.043.2943.3Targeting RAS signalling pathways in cancer therapy. Julian DownwardNat Rev Cancer200312509763No
84123482348.051.8351.8Rab GTPases as coordinators of vesicle traffic. Harald StenmarkNat Rev Mol Cell Biol200919603039No
84246922346.097.7348.9New functions for the matrix metalloproteinases in cancer progression. Mikala Egeblad, Zena WerbNat Rev Cancer200211990853No
84323462346.075.7875.8Epidemiology of viral hepatitis and hepatocellular carcinoma. Hashem B El-SeragGastroenterology201222537432No
84423452345.078.0478.0Working memory. A BaddeleyScience19921736359No
84570342344.770.3723.5On The Nature Of Allosteric Transitions: A Plausible Model. J Monod, J Wyman, J P ChangeuxJ Mol Biol196514343300Yes
84623442344.051.7551.8Mitochondrial diseases in man and mouse. D C WallaceScience199910066162No
84723442344.052.9252.9The inflammatory reflex. Kevin J TraceyNature200212490958No
84870292343.0154.2751.4The biology of VEGF and its receptors. Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouterNat Med200312778165No
84923432343.051.0251.0A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Douglas C WallaceAnnu Rev Genet200516285865No
85023422342.085.0385.0Calmodulin plays a pivotal role in cellular regulation. W Y CheungScience19806243188No
85123412341.051.9351.9The structure and regulation of protein phosphatases. P CohenAnnu Rev Biochem19892549856No
85246772338.5138.4669.2Missing data: our view of the state of the art. Joseph L Schafer, John W GrahamPsychol Methods200212090408Yes
85323372337.044.8544.9Mechanisms of type-I- and type-II-interferon-mediated signalling. Leonidas C PlataniasNat Rev Immunol200515864272No
85423342334.00.00.0Isolation by Distance. S WrightGenetics194317247074Yes
85546652332.5100.0150.0Judgment under Uncertainty: Heuristics and Biases. A Tversky, D KahnemanScience197417835457Yes
85646562328.0126.6863.3Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. G Kresse, J HafnerPhys Rev B Condens Matter199410010505Yes
85723272327.00.00.0Muscle structure and theories of contraction. A F HuxleyProg Biophys Biophys Chem195713485191Yes
85846532326.5130.2465.1Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. R A Laskey, A D MillsEur J Biochem19751175627Yes
85946472323.587.3943.7A novel genetic system to detect protein-protein interactions. S Fields, O SongNature19892547163Yes
86023232323.046.7446.7Stereochemistry of cooperative effects in haemoglobin. M F PerutzNature19705528785Yes
86146452322.5118.459.2Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Marie-Christine Daniel, Didier AstrucChem Rev200414719978No
86223212321.060.9961.0A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. P ChomczynskiBiotechniques19937692896Yes
86346412320.5161.0180.5The biofilm matrix. Hans-Curt Flemming, Jost WingenderNat Rev Microbiol201020676145No
86423182318.065.8565.8Inositol phospholipids and cell surface receptor function. R H MichellBiochim Biophys Acta1975164246No
86523182318.066.2966.3Interleukin-1 and interleukin-1 antagonism. C A DinarelloBlood19911826616No
86623182318.057.5857.6A model for receptor-regulated calcium entry. J W PutneyCell Calcium19862420465No
86746342317.0130.9565.5The number of people with glaucoma worldwide in 2010 and 2020. H A Quigley, A T BromanBr J Ophthalmol200616488940Yes
86823162316.055.3155.3Ischemic cell death in brain neurons. P LiptonPhysiol Rev199910508238No
86946312315.5126.3263.2Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Michael D Fox, Marcus E RaichleNat Rev Neurosci200717704812No
87023072307.057.0657.1Bcl-2 and the regulation of programmed cell death. J C ReedJ Cell Biol19948294493No
87146132306.5194.3997.2The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. H P Misra, I FridovichJ Biol Chem19724623845Yes
87223052305.048.7448.7NOX enzymes and the biology of reactive oxygen. J David LambethNat Rev Immunol200415039755No
87323042304.089.6789.7Effective physician-patient communication and health outcomes: a review. M A StewartCMAJ19957728691Yes
87446072303.574.3837.2On the size of the active site in proteases. I. Papain. I Schechter, A BergerBiochem Biophys Res Commun19676035483Yes
87546062303.0121.8460.9Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. C W Elston, I O EllisHistopathology19911757079Yes
87646032301.5102.2151.1AKT/PKB signaling: navigating downstream. Brendan D Manning, Lewis C CantleyCell200717604717No
87746012300.578.2739.1High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. M N Berry, D S FriendJ Cell Biol19694900611Yes
87822982298.071.8971.9Reactive oxygen species and the central nervous system. B HalliwellJ Neurochem19921402908No
87945922296.0115.8357.9Acute-phase proteins and other systemic responses to inflammation. C Gabay, I KushnerN Engl J Med19999971870No
88022952295.079.1579.2Gctf: Real-time CTF determination and correction. Kai ZhangJ Struct Biol201626592709Yes
88122922292.049.6449.6Nitric oxide and the immune response. C BogdanNat Immunol200111577346No
88245792289.5116.1458.1A receptor-mediated pathway for cholesterol homeostasis. M S Brown, J L GoldsteinScience19863513311No
88322892289.00.00.0[Rapid physiological coagulation method in determination of fibrinogen]. A ClaussActa Haematol195713434757Yes
88422892289.019.5919.6Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. T HiguchiJ Pharm Sci196314088963Yes
88545772288.5107.7453.9Protein misfolding, functional amyloid, and human disease. Fabrizio Chiti, Christopher M DobsonAnnu Rev Biochem200616756495No
88622882288.045.3145.3SV40-transformed simian cells support the replication of early SV40 mutants. Y GluzmanCell19816260373Yes
88745732286.589.9445.0The interpretation of protein structures: estimation of static accessibility. B Lee, F M RichardsJ Mol Biol19715551392Yes
88845702285.088.9844.5Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Yigong Shi, Joan MassaguéCell200312809600No
88922822282.078.678.6Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. F F JöbsisScience1977929199Yes
89022822282.056.2356.2Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. Jane GlazebrookAnnu Rev Phytopathol200516078883No
89122822282.061.7361.7Intestinal mucosal barrier function in health and disease. Jerrold R TurnerNat Rev Immunol200919855405No
89222802280.076.2576.2Glutamate, nitric oxide and cell-cell signalling in the nervous system. J GarthwaiteTrends Neurosci19911708538No
89368402280.0180.8860.3Regularization Paths for Generalized Linear Models via Coordinate Descent. Jerome Friedman, Trevor Hastie, Rob TibshiraniJ Stat Softw201020808728Yes
89422792279.057.9257.9Network pharmacology: the next paradigm in drug discovery. Andrew L HopkinsNat Chem Biol200818936753No
89545522276.0167.5783.8Self-rated health and mortality: a review of twenty-seven community studies. E L Idler, Y BenyaminiJ Health Soc Behav19979097506No
89645512275.5166.883.4The attention system of the human brain. M I Posner, S E PetersenAnnu Rev Neurosci19902183676No
89722752275.056.056.0An index to quantify an individual's scientific research output. J E HirschProc Natl Acad Sci U S A200516275915Yes
89822722272.049.1549.1Chemokines and leukocyte traffic. M BaggioliniNature19989560152No
89990872271.8216.3554.1Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. C A Lipinski, F Lombardo, B W Dominy, P J FeeneyAdv Drug Deliv Rev200111259830No
90022712271.057.5957.6A theory of cortical responses. Karl FristonPhilos Trans R Soc Lond B Biol Sci200515937014No
90122712271.0104.6104.6Deep learning in neural networks: an overview. Jürgen SchmidhuberNeural Netw201525462637No
90222702270.053.1153.1Specification of cerebral cortical areas. P RakicScience19883291116No
90322692269.042.8342.8Histone acetylation in chromatin structure and transcription. M GrunsteinNature19979311776No
90445332266.5110.8755.4Nonparametric permutation tests for functional neuroimaging: a primer with examples. Thomas E Nichols, Andrew P HolmesHum Brain Mapp200211747097Yes
90522652265.054.4454.4Lead- and drug-like compounds: the rule-of-five revolution. Christopher A LipinskiDrug Discov Today Technol200424981612Yes
90622642264.071.1471.1Human error: models and management. J ReasonBMJ200010720363Yes
90722622262.049.9249.9Intracellular aspects of the process of protein synthesis. G PaladeScience19751096303No
90822622262.093.3293.3The validity and practicality of sun-reactive skin types I through VI. T B FitzpatrickArch Dermatol19883377516Yes
90922602260.050.1650.2Application of a microtechnique to viral serological investigations. J L SeverJ Immunol196213910995Yes
91022592259.068.9168.9Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. R A DeFronzoDiabetes19883289989No
91122592259.060.0860.1The importance of selenium to human health. M P RaymanLancet200010963212No
91245182259.0121.7460.9Application of phylogenetic networks in evolutionary studies. Daniel H Huson, David BryantMol Biol Evol200616221896Yes
91322582258.068.6968.7A two process model of sleep regulation. A A BorbélyHum Neurobiol19827185792Yes
91445072253.595.1647.6Mass spectrometry-based proteomics. Ruedi Aebersold, Matthias MannNature200312634793No
91590012250.2196.7349.2Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. A Krogh, B Larsson, G von Heijne, E L SonnhammerJ Mol Biol200111152613Yes
91644992249.5102.7251.4A simple and very efficient method for generating cDNA libraries. U Gubler, B J HoffmanGene19836198242Yes
91722452245.055.1155.1Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J Kyhse-AndersenJ Biochem Biophys Methods19846530509Yes
91822452245.072.9472.9Eye movements in reading and information processing: 20 years of research. K RaynerPsychol Bull19989849112No
91922452245.058.0158.0The blood-brain barrier in health and chronic neurodegenerative disorders. Berislav V ZlokovicNeuron200818215617No
92022442244.0109.53109.5Mechanisms of action of transmitters and other substances on smooth muscle. T B BoltonPhysiol Rev197937533No
92122442244.044.2844.3The molecular biology of memory storage: a dialogue between genes and synapses. E R KandelScience200111691980No
92222442244.060.1360.1Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Claudiu T SupuranNat Rev Drug Discov200818167490No
92322432243.061.5161.5Molecular diversity of glutamate receptors and implications for brain function. S NakanishiScience19921329206No
92422412241.052.8652.9Mechanisms and genes of cellular suicide. H StellerScience19957878463No
92522412241.056.056.0RGD and other recognition sequences for integrins. E RuoslahtiAnnu Rev Cell Dev Biol19968970741No
92622402240.053.0753.1Protein kinase C and lipid signaling for sustained cellular responses. Y NishizukaFASEB J19957737456No
92722392239.083.7983.8Specific impairments of planning. T ShallicePhilos Trans R Soc Lond B Biol Sci19826125971Yes
92822392239.00.00.0Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. G BertaniJ Bacteriol195114888646Yes
92922362236.074.9374.9Simplified calculation of body-surface area. R D MostellerN Engl J Med19873657876Yes
93022352235.077.5377.5Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. B N AmesScience19836351251No
93122332233.058.158.1Working memory: looking back and looking forward. Alan BaddeleyNat Rev Neurosci200314523382No
93222322232.072.9272.9Qualitative research: standards, challenges, and guidelines. K MalterudLancet200111513933Yes
93322322232.058.6258.6MYC on the path to cancer. Chi V DangCell201222464321No
93444562228.098.3249.2Organization and expression of eucaryotic split genes coding for proteins. R Breathnach, P ChambonAnnu Rev Biochem19816791577No
93522262226.068.5968.6Biodiesel from microalgae. Yusuf ChistiBiotechnol Adv200717350212No
93644502225.0107.9754.0Regulation of the mevalonate pathway. J L Goldstein, M S BrownNature19901967820No
93722252225.049.0149.0The regulation of AP-1 activity by mitogen-activated protein kinases. M KarinJ Biol Chem19957622446No
93844502225.0128.9864.5Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. C J Murray, A D LopezLancet19979167458Yes
93922252225.070.5370.5Spinal and supraspinal factors in human muscle fatigue. S C GandeviaPhysiol Rev200111581501No
94022232223.064.4764.5Hazards of heavy metal contamination. Lars JärupBr Med Bull200314757716No
94144442222.039.5619.8A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. J E TILL, E A McCULLOCHRadiat Res196113776896Yes
94244372218.585.9143.0Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. T V Bliss, T LomoJ Physiol19734727084Yes
94322172217.058.2358.2Epidemiology of insomnia: what we know and what we still need to learn. Maurice M OhayonSleep Med Rev200212531146Yes
944177292216.1559.4169.9The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C SiebertN Engl J Med19938366922Yes
94522152215.0122.78122.8Determination and quantification of content validity. M R LynnNurs Res19863640358Yes
94644302215.091.2145.6The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J A Spudich, S WattJ Biol Chem19714254541Yes
94722142214.068.1668.2Prooxidant states and tumor promotion. P A CeruttiScience19852981433No
94822132213.0137.46137.5Presidential Address-1976. Social support as a moderator of life stress. S CobbPsychosom Med1976981490Yes
94922122212.083.3183.3Role of endothelium in responses of vascular smooth muscle. R F FurchgottCirc Res19836313250No
95022102210.063.2863.3TGFβ signalling in context. Joan MassaguéNat Rev Mol Cell Biol201222992590No
95144182209.096.3248.2Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. F Sallusto, A LanzavecchiaJ Exp Med19948145033Yes
95244182209.099.1849.6The Bcl-2 protein family: arbiters of cell survival. J M Adams, S CoryScience19989735050No
95322092209.053.7453.7Animal mitochondrial genomes. J L BooreNucleic Acids Res199910101183No
95422052205.065.5265.5Diagnosis of Alzheimer's disease. Z S KhachaturianArch Neurol19852864910Yes
95544062203.099.2149.6Brown adipose tissue: function and physiological significance. Barbara Cannon, Jan NedergaardPhysiol Rev200414715917No
95643982199.0107.3253.7A scaling normalization method for differential expression analysis of RNA-seq data. Mark D Robinson, Alicia OshlackGenome Biol201020196867Yes
95721962196.089.089.0Role of Streptococcus mutans in human dental decay. W J LoescheMicrobiol Rev19863540569No
95821952195.054.954.9Removal of fatty acids from serum albumin by charcoal treatment. R F ChenJ Biol Chem19676016603Yes
95921952195.061.9161.9Hybrid porous solids: past, present, future. Gérard FéreyChem Soc Rev200818197340Yes
96021942194.057.4757.5Pancreatic cancer. Manuel HidalgoN Engl J Med201020427809No
96121932193.069.9670.0Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. W A CraigClin Infect Dis19989455502No
96221922192.079.2979.3Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. H W SteinbuschNeuroscience19817017455Yes
96321912191.063.763.7Social determinants of health inequalities. Michael MarmotLancet200515781105Yes
96421892189.041.2741.3Shelterin: the protein complex that shapes and safeguards human telomeres. Titia de LangeGenes Dev200516166375No
96543722186.0118.2559.1A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Y Matsumura, H MaedaCancer Res19862946403Yes
96643682184.0125.0662.5Distributed hierarchical processing in the primate cerebral cortex. D J Felleman, D C Van EssenCereb Cortex19911822724No
96721822182.048.4348.4Chemokines. B J RollinsBlood19979242519No
96821792179.054.054.0P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation. Berk HessJ Chem Theory Comput200826619985Yes
96921782178.090.6790.7A systematic method for clinical description and classification of personality variants. A proposal. C R CloningerArch Gen Psychiatry19873579504Yes
97021772177.046.4846.5Complement. First of two parts. M J WalportN Engl J Med200111287977No
971195812175.7933.96103.8Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie BrayInt J Cancer201525220842Yes
97243502175.0110.9855.5Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. M Matsuda, R A DeFronzoDiabetes Care199910480510Yes
97321752175.053.4153.4Breast cancer and hormone-replacement therapy in the Million Women Study. Valerie BeralLancet200312927427Yes
97421752175.065.2565.2PsychoPy--Psychophysics software in Python. Jonathan W PeirceJ Neurosci Methods200717254636Yes
97521752175.075.6975.7Large-scale brain networks and psychopathology: a unifying triple network model. Vinod MenonTrends Cogn Sci201121908230No
97621742174.055.3455.3Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. R D Pascual-MarquiMethods Find Exp Clin Pharmacol200212575463No
97721732173.086.386.3Approximate entropy as a measure of system complexity. S M PincusProc Natl Acad Sci U S A199111607165Yes
97865042168.0250.5183.5Glucose clamp technique: a method for quantifying insulin secretion and resistance. R A DeFronzo, J D Tobin, R AndresAm J Physiol1979382871Yes
97921682168.065.7365.7Fetal origins of coronary heart disease. D J BarkerBMJ19957613432No
98086682167.0209.7452.4Matrix elasticity directs stem cell lineage specification. Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E DischerCell200616923388Yes
98121622162.071.4371.4A classification of glycosyl hydrolases based on amino acid sequence similarities. B HenrissatBiochem J19911747104Yes
98243232161.5104.7252.4Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Michael T Lin, M Flint BealNature200617051205No
98321612161.041.8241.8Protein modules and signalling networks. T PawsonNature19957531822No
98421612161.060.0160.0Superoxide radical and superoxide dismutases. I FridovichAnnu Rev Biochem19957574505No
98564822160.7132.0344.0Immunochemical quantitation of antigens by single radial immunodiffusion. G Mancini, A O Carbonara, J F HeremansImmunochemistry19654956917Yes
98621592159.069.7169.7Keratoconus. Y S RabinowitzSurv Ophthalmol19989493273No
98721582158.058.4958.5The episodic buffer: a new component of working memory? A BaddeleyTrends Cogn Sci200011058819Yes
98843162158.00.00.0Loss of recent memory after bilateral hippocampal lesions. W B Scoville, B MilnerJ Neurol Neurosurg Psychiatry195713406589Yes
98921572157.047.9648.0A clearer vision for in vivo imaging. R WeisslederNat Biotechnol200111283581No
99021562156.030.9931.0Sedimentation Studies Of The Size And Shape Of Dna. F W StudierJ Mol Biol196514290352Yes
99143112155.5148.2174.1Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. R B Devereux, N ReichekCirculation1977138494Yes
99221552155.046.9647.0The distribution of secondary growths in cancer of the breast. 1889. S PagetCancer Metastasis Rev19892673568No
99321552155.058.4358.4Biofilms: microbial life on surfaces. Rodney M DonlanEmerg Infect Dis200212194761No
99421532153.049.4149.4Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. G TrinchieriAnnu Rev Immunol19957612223No
99543052152.5123.9662.0Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. J S Beckman, W H KoppenolAm J Physiol19968944624No
99621502150.049.049.0Pathways towards and away from Alzheimer's disease. Mark P MattsonNature200415295589No
99721482148.054.2754.3The extracellular matrix: not just pretty fibrils. Richard O HynesScience200919965464No
99842952147.5111.5855.8ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. B Ravel, M NewvilleJ Synchrotron Radiat200515968136Yes
99942942147.0100.9850.5Assembly of asparagine-linked oligosaccharides. R Kornfeld, S KornfeldAnnu Rev Biochem19853896128No
100021472147.00.00.0Analysis of tissue and arterial blood temperatures in the resting human forearm. H H PennesJ Appl Physiol194818887578Yes
100142932146.581.3140.7Variations in pattern of pubertal changes in girls. W A Marshall, J M TannerArch Dis Child19695785179Yes
100242922146.0107.5453.8Function and activation of NF-kappa B in the immune system. P A Baeuerle, T HenkelAnnu Rev Immunol19948011280No
100321462146.0110.15110.2The antibiotic resistance crisis: part 1: causes and threats. C Lee VentolaP T201525859123Yes
100421452145.054.8454.8Descending control of pain. Mark J MillanProg Neurobiol200212034378No
100542892144.574.1937.1A Simplified Lead Citrate Stain For Use In Electron Microscopy. J H Venable, R CoggeshallJ Cell Biol196514287192Yes
100621422142.055.8855.9The molecular pathology of Alzheimer's disease. D J SelkoeNeuron19911673054No
100721422142.056.0456.0The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. D E AtkinsonBiochemistry19684972613Yes
100864262142.0191.3863.8The brain's default network: anatomy, function, and relevance to disease. Randy L Buckner, Jessica R Andrews-Hanna, Daniel L SchacterAnn N Y Acad Sci200818400922No
100921392139.014.3414.3The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. W W ClelandBiochim Biophys Acta196314021667Yes
101021382138.00.00.0A new specific color reaction of hexuronic acids. Z DischeJ Biol Chem194720281638Yes
101164102136.7185.2861.8Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. C E Murry, R B Jennings, K A ReimerCirculation19863769170Yes
101242672133.5102.251.1Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Hashem B El-Serag, K Lenhard RudolphGastroenterology200717570226No
101321332133.038.8538.9Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. P MitchellBiol Rev Camb Philos Soc19665329743No
101421322132.052.8652.9Using circular dichroism spectra to estimate protein secondary structure. Norma J GreenfieldNat Protoc200617406547Yes
101521322132.060.5360.5Infrared spectroscopy of proteins. Andreas BarthBiochim Biophys Acta200717692815No
101621272127.050.3750.4Patterns of amino acids near signal-sequence cleavage sites. G von HeijneEur J Biochem19836852022Yes
101742472123.5122.0961.0Angiogenic factors. J Folkman, M KlagsbrunScience19872432664No
101863672122.3145.9448.6MOLMOL: a program for display and analysis of macromolecular structures. R Koradi, M Billeter, K WüthrichJ Mol Graph19968744573Yes
101921222122.039.8439.8NK cell recognition. Lewis L LanierAnnu Rev Immunol200515771571No
102084852121.2172.4243.1WebLogo: a sequence logo generator. Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E BrennerGenome Res200415173120Yes
102142422121.080.5440.3The fundamental role of epigenetic events in cancer. Peter A Jones, Stephen B BaylinNat Rev Genet200212042769No
102221212121.043.2543.2Role of angiogenesis in tumor growth and metastasis. Judah FolkmanSemin Oncol200212516034No
102321202120.045.4145.4Theta oscillations in the hippocampus. György BuzsákiNeuron200211832222No
102421192119.044.5944.6Mammalian G1 cyclins. C J SherrCell19938513492No
102521192119.050.9551.0Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Edward V LoftusGastroenterology200415168363Yes
102621182118.035.7135.7Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. D AminoffBiochem J196113860975Yes
102763512117.0282.4594.1Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. B N Ames, J Mccann, E YamasakiMutat Res1975768755Yes
102821162116.042.4342.4Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Shimon SakaguchiNat Immunol200515785760No
102963442114.7176.158.7Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. F E Harrell, K L Lee, D B MarkStat Med19968668867No
103021132113.048.148.1Comparison of the predicted and observed secondary structure of T4 phage lysozyme. B W MatthewsBiochim Biophys Acta19751180967Yes
103142222111.0181.2690.6The Health Belief Model: a decade later. N K Janz, M H BeckerHealth Educ Q19846392204No
103221112111.064.064.0The unbiased estimation of number and sizes of arbitrary particles using the disector. D C SterioJ Microsc19846737468Yes
103363322110.7119.2739.8Control of regulatory T cell development by the transcription factor Foxp3. Shohei Hori, Takashi Nomura, Shimon SakaguchiScience200312522256Yes
103421102110.053.0453.0Accurate description of van der Waals complexes by density functional theory including empirical corrections. Stefan GrimmeJ Comput Chem200415224390Yes
103563292109.7197.3565.8Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. R L Spitzer, K Kroenke, J B WilliamsJAMA199910568646Yes
103642132106.5106.6253.3Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. E Lander, L KruglyakNat Genet19957581446Yes
103763152105.0160.0753.4GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. R A Jefferson, T A Kavanagh, M W BevanEMBO J19873327686Yes
103842072103.5134.0167.0A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Gary J Bennett, Y-K XiePain19882837713Yes
103921032103.089.3789.4What's in a name? Qualitative description revisited. Margarete SandelowskiRes Nurs Health201020014004Yes
104021012101.054.2554.2The physiology of glucagon-like peptide 1. Jens Juul HolstPhysiol Rev200717928588No
1041126032100.5281.3546.9NMRPipe: a multidimensional spectral processing system based on UNIX pipes. F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A BaxJ Biomol NMR19958520220Yes
104221002100.0531.11531.1Hallmarks of Cancer: New Dimensions. Douglas HanahanCancer Discov202235022204No
104341992099.582.3441.2Network biology: understanding the cell's functional organization. Albert-László Barabási, Zoltán N OltvaiNat Rev Genet200414735121No
104420952095.090.4390.4The Children's Depression, Inventory (CDI). M KovacsPsychopharmacol Bull19854089116Yes
104520942094.051.1751.2The plasma lecithins:cholesterol acyltransferase reaction. J A GlomsetJ Lipid Res19684868699No
104620942094.061.4361.4Hypoxia-inducible factors in physiology and medicine. Gregg L SemenzaCell201222304911No
104720932093.092.0192.0Method For Assay Of Intestinal Disaccharidases. A DahlqvistAnal Biochem196414106916Yes
104820912091.083.2283.2A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. E L BradleyArch Surg19938489394No
104941802090.0143.2671.6Shifting the genomic gold standard for the prokaryotic species definition. Michael Richter, Ramon Rosselló-MóraProc Natl Acad Sci U S A200919855009Yes
105041762088.0110.4555.2The inflammasomes. Kate Schroder, Jurg TschoppCell201020303873No
105141752087.582.341.1Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Rik Derynck, Ying E ZhangNature200314534577No
105220872087.045.7545.8Biology of natural killer cells. G TrinchieriAdv Immunol19892683611No
105320852085.0112.24112.2The assessment of clinical skills/competence/performance. G E MillerAcad Med19902400509Yes
105441652082.5109.1254.6The heat-shock proteins. S Lindquist, E A CraigAnnu Rev Genet19882853609No
105520812081.0103.14103.1Metazoan MicroRNAs. David P BartelCell201829570994No
105641602080.0101.5450.8Measuring the thickness of the human cerebral cortex from magnetic resonance images. B Fischl, A M DaleProc Natl Acad Sci U S A200010984517Yes
105720772077.055.4855.5Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. J W LittlefieldScience196414168277Yes
105820752075.063.6163.6Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Leonardo PantoniLancet Neurol201020610345No
105962242074.7146.9549.0APE: Analyses of Phylogenetics and Evolution in R language. Emmanuel Paradis, Julien Claude, Korbinian StrimmerBioinformatics200414734327Yes
106041482074.0100.8250.4Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. G G Glenner, C W WongBiochem Biophys Res Commun19846375662Yes
106120742074.074.1774.2International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. C HerrmannJ Psychosom Res19979055211No
106220742074.050.7550.8Drug-like properties and the causes of poor solubility and poor permeability. C A LipinskiJ Pharmacol Toxicol Methods200011274893No
106341462073.086.843.4A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. G Shaw, R KamenCell19863488815Yes
106420732073.045.4845.5Defensins: antimicrobial peptides of innate immunity. Tomas GanzNat Rev Immunol200312949495No
106520712071.038.038.0Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. J C SkouPhysiol Rev196514337569No
106662122070.7127.8542.6EMBOSS: the European Molecular Biology Open Software Suite. P Rice, I Longden, A BleasbyTrends Genet200010827456Yes
106741392069.582.0841.0Mammalian MAP kinase signalling cascades. L Chang, M KarinNature200111242034No
106820692069.053.3953.4The heme oxygenase system: a regulator of second messenger gases. M D MainesAnnu Rev Pharmacol Toxicol19979131263No
106941372068.536.4818.2Genetic regulatory mechanisms in the synthesis of proteins. F Jacob, J MonodJ Mol Biol196113718526Yes
107020682068.059.5459.5ATP-regulated K+ channels in cardiac muscle. A NomaNature19836310409Yes
107182662066.5304.1376.0Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanJ Clin Epidemiol200919631508No
107220662066.050.1350.1Dopamine, learning and motivation. Roy A WiseNat Rev Neurosci200415152198No
107320652065.042.5242.5G1 events and regulation of cell proliferation. A B PardeeScience19892683075No
107441242062.081.3740.7Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. M Gossen, H BujardProc Natl Acad Sci U S A19921319065Yes
107520612061.0102.12102.1Abiotic Stress Signaling and Responses in Plants. Jian-Kang ZhuCell201627716505No
107641202060.00.00.0Plaque formation and isolation of pure lines with poliomyelitis viruses. R Dulbecco, M VogtJ Exp Med195413130792Yes
107720592059.048.5348.5Interleukin-2: inception, impact, and implications. K A SmithScience19883131876No
107841072053.5111.1555.6New perspectives in cell adhesion: RGD and integrins. E Ruoslahti, M D PierschbacherScience19872821619No
107920532053.068.6468.6Purinergic nerves. G BurnstockPharmacol Rev19724404211No
108041032051.580.7540.4Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Rudolf Jaenisch, Adrian BirdNat Genet200312610534No
108120512051.051.4551.5Determination and analysis of urea and guanidine hydrochloride denaturation curves. C N PaceMethods Enzymol19863773761Yes
108220502050.053.2753.3Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Gökhan S HotamisligilCell201020303879No
108320452045.073.0173.0Determination of glutathione and glutathione disulfide in biological samples. M E AndersonMethods Enzymol19854088074Yes
108440892044.5100.7550.4Cutaneous wound healing. A J Singer, R A ClarkN Engl J Med199910471461No
108520442044.047.7147.7Metabolomics--the link between genotypes and phenotypes. Oliver FiehnPlant Mol Biol200211860207No
108620442044.066.8666.9Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. Peter C AustinPharm Stat201120925139Yes
108740872043.5183.5791.8Stages and processes of self-change of smoking: toward an integrative model of change. J O Prochaska, C C DiClementeJ Consult Clin Psychol19836863699Yes
108820392039.058.3858.4Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. M LeavittMedGenMed200111549951No
108961142038.0182.4460.8Arlequin (version 3.0): an integrated software package for population genetics data analysis. Laurent Excoffier, Guillaume Laval, Stefan SchneiderEvol Bioinform Online200719325852Yes
109020372037.047.7847.8Calcium signaling. D E ClaphamCell19957834745No
109120372037.041.2741.3Metastasis to bone: causes, consequences and therapeutic opportunities. Gregory R MundyNat Rev Cancer200212154351No
109240712035.598.5849.3Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. P Liang, A B PardeeScience19921354393Yes
109340702035.0173.4686.7The MOS social support survey. C D Sherbourne, A L StewartSoc Sci Med19912035047Yes
109461052035.0201.0167.0Parallel organization of functionally segregated circuits linking basal ganglia and cortex. G E Alexander, M R DeLong, P L StrickAnnu Rev Neurosci19863085570No
109520352035.039.5839.6Signalling pathways of the TNF superfamily: a double-edged sword. Bharat B AggarwalNat Rev Immunol200312949498No
109620342034.041.9842.0Molecular bases for circadian clocks. J C DunlapCell19999988221No
109720342034.050.4250.4Mechanisms of hepatic fibrogenesis. Scott L FriedmanGastroenterology200818471545No
109840652032.5112.8156.4Autophagy: renovation of cells and tissues. Noboru Mizushima, Masaaki KomatsuCell201122078875No
109920322032.056.5356.5Estimating causal effects from large data sets using propensity scores. D B RubinAnn Intern Med19979382394No
110040642032.0124.7462.4Macrophage plasticity and polarization: in vivo veritas. Antonio Sica, Alberto MantovaniJ Clin Invest201222378047No
110160942031.3188.262.7Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. Aleksandr V Marenich, Christopher J Cramer, Donald G TruhlarJ Phys Chem B200919366259Yes
110240612030.5129.0164.5Polymyositis and dermatomyositis (first of two parts). A Bohan, J B PeterN Engl J Med19751090839No
110381212030.2266.6366.7Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. A J Hughes, S E Daniel, L Kilford, A J LeesJ Neurol Neurosurg Psychiatry19921564476Yes
110420292029.064.1364.1Health consequences of intimate partner violence. Jacquelyn C CampbellLancet200211965295No
110520292029.046.6746.7Follicular helper CD4 T cells (TFH). Shane CrottyAnnu Rev Immunol201121314428No
110620272027.044.444.4Structural design and molecular evolution of a cytokine receptor superfamily. J F BazanProc Natl Acad Sci U S A19902169613Yes
1107101222024.4236.9747.4Development and testing of a general amber force field. Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A CaseJ Comput Chem200415116359Yes
110820242024.051.2951.3Analysis of bacteriophage T7 early RNAs and proteins on slab gels. F W StudierJ Mol Biol19734760132Yes
110920242024.00.00.0Antigen-antibody reactions in gels. O OuchterlonyActa Pathol Microbiol Scand194918143039Yes
111020242024.062.9262.9Ethical authorship and publishing. Andrew J S CoatsInt J Cardiol200919046787No
111140482024.0118.4959.2Wnt/β-catenin signaling and disease. Hans Clevers, Roel NusseCell201222682243No
111280892022.2173.7843.4MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi MiyataNucleic Acids Res200212136088Yes
111320202020.058.5358.5Protein oxidation and aging. E R StadtmanScience19921355616No
111440392019.594.6747.3Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. B A Reynolds, S WeissScience19921553558Yes
111540332016.579.4139.7The Wnt signaling pathway in development and disease. Catriona Y Logan, Roel NusseAnnu Rev Cell Dev Biol200415473860No
111660402013.3227.6175.9Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. G Muyzer, E C de Waal, A G UitterlindenAppl Environ Microbiol19937683183Yes
111720132013.039.0939.1CpG motifs in bacterial DNA and their immune effects. Arthur M KriegAnnu Rev Immunol200211861616No
1118120772012.8379.5363.3Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell ParkinInt J Cancer201021351269Yes
111920092009.035.0935.1ATM and related protein kinases: safeguarding genome integrity. Yosef ShilohNat Rev Cancer200312612651No
112020072007.041.6441.6XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. D E McReeJ Struct Biol199910222271Yes
112160152005.0193.0964.4Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. C Lord, M Rutter, A Le CouteurJ Autism Dev Disord19947814313Yes
112220012001.046.946.9DAMPs, PAMPs and alarmins: all we need to know about danger. Marco E BianchiJ Leukoc Biol200717032697No
112319991999.047.3847.4Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Scott L FriedmanPhysiol Rev200818195085No
112419971997.042.4742.5The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. U E LoeningBiochem J19675339944Yes
112539941997.00.00.0A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. R F Beers, I W SizerJ Biol Chem195214938361Yes
112619951995.036.5736.6In situ hybridization: an improved whole-mount method for Xenopus embryos. R M HarlandMethods Cell Biol19911811161Yes
112739901995.096.5448.3Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. M Nei, T GojoboriMol Biol Evol19863444411Yes
112819951995.078.1378.1Perception of risk. P SlovicScience19873563507Yes
112939881994.0107.6453.8The unfolded protein response: from stress pathway to homeostatic regulation. Peter Walter, David RonScience201122116877No
113039851992.5172.786.3The Brief Symptom Inventory: an introductory report. L R Derogatis, N MelisaratosPsychol Med19836622612Yes
113119911991.040.9841.0Mechanisms of intracellular protein transport. J E RothmanNature19947969419No
113239811990.5102.7151.4Building better batteries. M Armand, J-M TarasconNature200818256660No
113319901990.082.882.8A rating scale for drug-induced akathisia. T R BarnesBr J Psychiatry19892574607Yes
113479561989.0378.294.5The Satisfaction With Life Scale. E Diener, R A Emmons, R J Larsen, S GriffinJ Pers Assess198516367493Yes
113519881988.050.5950.6Flow-mediated endothelial mechanotransduction. P F DaviesPhysiol Rev19957624393No
113639741987.086.0743.0The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. A J Ridley, A HallCell19921643657Yes
113719861986.048.3848.4Interfaces and the driving force of hydrophobic assembly. David ChandlerNature200516193038No
113819851985.053.0653.1Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. J FolkmanN Engl J Med19957491141No
113939681984.085.2642.6Lessons from hereditary colorectal cancer. K W Kinzler, B VogelsteinCell19968861899No
114039661983.0143.5971.8Deciphering key features in protein structures with the new ENDscript server. Xavier Robert, Patrice GouetNucleic Acids Res201424753421Yes
114119821982.095.2395.2Performance-oriented assessment of mobility problems in elderly patients. M E TinettiJ Am Geriatr Soc19863944402Yes
114219821982.039.2139.2DNA topoisomerases: structure, function, and mechanism. J J ChampouxAnnu Rev Biochem200111395412No
114379271981.8296.8974.2The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. T F Heatherton, L T Kozlowski, R C Frecker, K O FagerströmBr J Addict19911932883Yes
114419811981.038.2838.3Antiviral actions of interferons. C E SamuelClin Microbiol Rev200111585785No
114519801980.054.454.4The biology of interleukin-6. T KishimotoBlood19892473791No
114619791979.055.3455.3Japanese Classification of Gastric Carcinoma - 2nd English Edition - Japanese Gastric Cancer AssociationGastric Cancer199811957040Yes
114719761976.065.8565.8The use of a plus-maze to measure anxiety in the mouse. R G ListerPsychopharmacology (Berl)19873110839Yes
114819741974.021.8621.9Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? J V NeelAm J Hum Genet196213937884Yes
114939441972.097.748.9Leptin and the regulation of body weight in mammals. J M Friedman, J L HalaasNature19989796811No
115019701970.041.5641.6TRP channels as cellular sensors. David E ClaphamNature200314654832No
115139391969.589.9445.0The acute respiratory distress syndrome. L B Ware, M A MatthayN Engl J Med200010793167No
115219691969.058.1158.1Intracellular calcium homeostasis. E CarafoliAnnu Rev Biochem19873304139No
115319671967.049.5849.6The glomerular permeability determined by dextran clearance using Sephadex gel filtration. C E MogensenScand J Clin Lab Invest19685637478Yes
115419671967.071.6471.6UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. D W RussellJ Pers Assess19968576833Yes
115519671967.041.6541.6Developmental regulation of the growth plate. Henry M KronenbergNature200312748651No
115619661966.048.5448.5Negative refraction makes a perfect lens J B PendryPhys Rev Lett200011041972Yes
1157137611965.9303.7743.4Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank SpelemanGenome Biol200212184808Yes
115839291964.589.945.0Base-calling of automated sequencer traces using phred. II. Error probabilities. B Ewing, P GreenGenome Res19989521922Yes
115919641964.086.3686.4A modified card sorting test sensitive to frontal lobe defects. H E NelsonCortex19761009768Yes
116019631963.035.0735.1Signaling--2000 and beyond. T HunterCell200010647936No
116119621962.055.0855.1Flavonoids as antioxidants. P G PiettaJ Nat Prod200010924197No
116239231961.596.7348.4Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. P J Barnes, M KarinN Engl J Med19979091804No
116319611961.00.00.0Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. M KunitzJ Gen Physiol194719873496Yes
116458811960.3121.3140.4Rapid and efficient site-specific mutagenesis without phenotypic selection. T A Kunkel, J D Roberts, R A ZakourMethods Enzymol19873323813Yes
116519591959.050.1450.1What is cognitive reserve? Theory and research application of the reserve concept. Yaakov SternJ Int Neuropsychol Soc200211939702No
116619591959.042.742.7Neutrophils and immunity: challenges and opportunities. Carl NathanNat Rev Immunol200616498448No
116739161958.0107.3753.7Insulin-like growth factors and their binding proteins: biological actions. J I Jones, D R ClemmonsEndocr Rev19957758431No
116839111955.565.4932.7Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. I W McLean, P K NakaneJ Histochem Cytochem19744374474Yes
116919551955.00.00.0The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. S V BoydenJ Exp Med195114803635Yes
117019541954.079.8579.8Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. A FleckensteinAnnu Rev Pharmacol Toxicol1977326161No
117119531953.038.1538.1Approaching the asymptote? Evolution and revolution in immunology. C A JanewayCold Spring Harb Symp Quant Biol19892700931No
117239061953.074.4437.2SIFT: Predicting amino acid changes that affect protein function. Pauline C Ng, Steven HenikoffNucleic Acids Res200312824425Yes
117339051952.5109.4254.7Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. B J Marshall, J R WarrenLancet19846145023Yes
117439041952.0123.6861.8Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. A C Chang, S N CohenJ Bacteriol1978149110Yes
117519521952.058.5258.5Global epidemiology of oral and oropharyngeal cancer. Saman WarnakulasuriyaOral Oncol200918804401No
117619511951.00.00.0On estimating the relation between blood group and disease. B WoolfAnn Hum Genet195514388528Yes
117719511951.090.5690.6The brain's default mode network. Marcus E RaichleAnnu Rev Neurosci201525938726No
117819501950.060.3460.3Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. J P ChamberlainAnal Biochem1979543547Yes
117919501950.058.8758.9Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? George A BonannoAm Psychol200414736317No
118019481948.00.00.0Influences of glucose loading and of injected insulin on hepatic glucose output. R SteeleAnn N Y Acad Sci195913833973Yes
118119471947.038.6738.7DNA methylation and human disease. Keith D RobertsonNat Rev Genet200516136652No
118258401946.7189.7963.3AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. P G Reeves, F H Nielsen, G C FaheyJ Nutr19938229312No
118319461946.069.3969.4The emerging role of lncRNAs in cancer. Maite HuarteNat Med201526540387No
118419451945.064.2664.3Intermediate filaments as mechanical integrators of cellular space. E LazaridesNature19807188712Yes
118519431943.043.2843.3Signal sequences. The limits of variation. G von HeijneJ Mol Biol19854032478Yes
118619431943.053.5853.6Trail Making Test A and B: normative data stratified by age and education. Tom N TombaughArch Clin Neuropsychol200415010086Yes
118777711942.8323.0880.8jModelTest 2: more models, new heuristics and parallel computing. Diego Darriba, Guillermo L Taboada, Ramón Doallo, David PosadaNat Methods201222847109Yes
118819411941.055.4455.4Excitotoxic cell death. D W ChoiJ Neurobiol19921361523No
118977641941.0231.5257.9Antibiotic susceptibility testing by a standardized single disk method. A W Bauer, W M Kirby, J C Sherris, M TurckAm J Clin Pathol19665325707Yes
119038801940.094.7447.4Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. J G Rheinwald, H GreenCell19751052771Yes
119119401940.037.7337.7Systems biology: a brief overview. Hiroaki KitanoScience200211872829No
119219401940.040.8940.9The immunopathogenesis of sepsis. Jonathan CohenNature200212490963No
119319391939.045.7445.7Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. A BreslowAnn Surg19705477666Yes
119458081936.0175.858.6Estimating the mean and variance from the median, range, and the size of a sample. Stela Pudar Hozo, Benjamin Djulbegovic, Iztok HozoBMC Med Res Methodol200515840177Yes
119558081936.0168.0356.0GSVA: gene set variation analysis for microarray and RNA-seq data. Sonja Hänzelmann, Robert Castelo, Justin GuinneyBMC Bioinformatics201323323831Yes
1196135481935.4310.7444.4Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya YamanakaCell200718035408Yes
119719351935.040.3940.4A cell culture model for T lymphocyte clonal anergy. R H SchwartzScience19902113314Yes
119838681934.0135.1767.6Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. W R Morrison, L M SmithJ Lipid Res196414221106Yes
119919331933.057.4157.4Calbindin D-28k and parvalbumin in the rat nervous system. M R CelioNeuroscience19902199841Yes
120019331933.044.7144.7Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. B L WajchenbergEndocr Rev200011133069No
120157991933.0107.3735.8Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Jason D Fontenot, Marc A Gavin, Alexander Y RudenskyNat Immunol200312612578Yes
120219331933.045.4545.5The global health burden of infection-associated cancers in the year 2002. Donald Maxwell ParkinInt J Cancer200616404738Yes
120319321932.038.9939.0The complex language of chromatin regulation during transcription. Shelley L BergerNature200717522673No
120419311931.061.0161.0Sick individuals and sick populations. G RoseInt J Epidemiol19853872850Yes
120519311931.039.839.8Thrombin signalling and protease-activated receptors. S R CoughlinNature200011001069No
120677201930.0189.5247.4Cancer-related inflammation. Alberto Mantovani, Paola Allavena, Antonio Sica, Frances BalkwillNature200818650914No
120738591929.5102.951.5Inositol phosphates and cell signalling. M J Berridge, R F IrvineNature19892550825No
120819291929.050.4950.5DNA topoisomerase poisons as antitumor drugs. L F LiuAnnu Rev Biochem19892549853No
120938581929.087.9244.0Liver fibrosis. Ramón Bataller, David A BrennerJ Clin Invest200515690074No
121019291929.062.5562.5Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Sergio PecorelliInt J Gynaecol Obstet200919367689No
121138561928.095.0347.5The endophenotype concept in psychiatry: etymology and strategic intentions. Irving I Gottesman, Todd D GouldAm J Psychiatry200312668349No
121238551927.589.2944.6PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. Alexander W Schüttelkopf, Daan M F van AaltenActa Crystallogr D Biol Crystallogr200415272157Yes
121338531926.584.942.5Issues and challenges facing rechargeable lithium batteries. J M Tarascon, M ArmandNature200111713543Yes
121419261926.060.660.6Epidemiological features of chronic low-back pain. G B AnderssonLancet199910470716No
121538491924.586.0943.0The DNA-damage response in human biology and disease. Stephen P Jackson, Jiri BartekNature200919847258No
1216307891924.31004.2762.8Fiji: an open-source platform for biological-image analysis. Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert CardonaNat Methods201222743772Yes
121719241924.061.0461.0Calculation of substrate oxidation rates in vivo from gaseous exchange. K N FraynJ Appl Physiol Respir Environ Exerc Physiol19836618956Yes
121838471923.5123.6461.8Oxygen toxicity, oxygen radicals, transition metals and disease. B Halliwell, J M GutteridgeBiochem J19846326753No
121938471923.5114.1157.1Oncology meets immunology: the cancer-immunity cycle. Daniel S Chen, Ira MellmanImmunity201323890059No
122019221922.046.9847.0DNA topoisomerases. J C WangAnnu Rev Biochem19852992360No
122119221922.00.00.0On respiratory impairment in cancer cells. O WarburgScience195613351639Yes
122238411920.573.7136.9Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. M Karin, Y Ben-NeriahAnnu Rev Immunol200010837071No
122319201920.033.7933.8Mechanisms of alternative pre-messenger RNA splicing. Douglas L BlackAnnu Rev Biochem200312626338No
122419201920.0139.95139.9Obesity: global epidemiology and pathogenesis. Matthias BlüherNat Rev Endocrinol201930814686No
122519191919.046.6246.6Thioredoxin. A HolmgrenAnnu Rev Biochem19853896121No
122619181918.052.5652.6Determination of minimum inhibitory concentrations. J M AndrewsJ Antimicrob Chemother200111420333Yes
122719171917.038.9539.0The expanding role of mitochondria in apoptosis. X WangGenes Dev200111711427No
122819171917.045.445.4The dawning era of polymer therapeutics. Ruth DuncanNat Rev Drug Discov200312750738No
122919161916.082.9783.0Brain dopamine receptors. P SeemanPharmacol Rev19806117090No
123019161916.059.9760.0A new automated colorimetric method for measuring total oxidant status. Ozcan ErelClin Biochem200516214125Yes
123119151915.063.1963.2Physiological actions of taurine. R J HuxtablePhysiol Rev19921731369No
123219151915.033.8333.8The regulation of E2F by pRB-family proteins. N DysonGenes Dev19989694791No
123319141914.040.8340.8The etiology of chondromalacia patellae. R E OuterbridgeJ Bone Joint Surg Br196114038135Yes
123476541913.5188.7247.2p53 mutations in human cancers. M Hollstein, D Sidransky, B Vogelstein, C C HarrisScience19911905840No
123576541913.5298.3774.6A simple technique for quantitation of low levels of DNA damage in individual cells. N P Singh, M T McCoy, R R Tice, E L SchneiderExp Cell Res19883345800Yes
123619121912.053.9954.0Introduction and General Overview of Cyclodextrin Chemistry. József SzejtliChem Rev199811848947Yes
123719111911.042.9543.0High-speed scanning in human memory. S SternbergScience19665939936Yes
123819101910.036.5436.5Notch signalling: a simple pathway becomes complex. Sarah J BrayNat Rev Mol Cell Biol200616921404No
123938191909.50.00.0Acetylornithinase of Escherichia coli: partial purification and some properties. H J Vogel, D M BonnerJ Biol Chem195613278318Yes
124019091909.062.5662.6The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. G S ManningQ Rev Biophys1978353876No
124119091909.049.1149.1Dengue and dengue hemorrhagic fever. D J GublerClin Microbiol Rev19989665979No
124219091909.055.6955.7Inhibited spontaneous emission in solid-state physics and electronics. E YablonovitchPhys Rev Lett198710034639Yes
124357241908.0187.9862.7Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. L Excoffier, P E Smouse, J M QuattroGenetics19921644282Yes
124438161908.098.1349.1Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering S Nie, S R EmoryScience19979027306Yes
124519081908.041.3741.4A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. J SantaLuciaProc Natl Acad Sci U S A19989465037Yes
124619081908.039.1339.1Mechanisms of cancer drug resistance. Michael M GottesmanAnnu Rev Med200211818492No
124719081908.046.2246.2Cancer chemoprevention with dietary phytochemicals. Young-Joon SurhNat Rev Cancer200314570043No
124838141907.0127.8663.9Mathematical model for studying genetic variation in terms of restriction endonucleases. M Nei, W H LiProc Natl Acad Sci U S A1979291943Yes
124938121906.0119.3659.7Efficient pseudopotentials for plane-wave calculations. N Troullier, J L MartinsPhys Rev B Condens Matter19919997467Yes
125019061906.061.0761.1Grounded cognition. Lawrence W BarsalouAnnu Rev Psychol200817705682No
125119041904.046.2146.2Episodic memory: from mind to brain. Endel TulvingAnnu Rev Psychol200211752477Yes
125257051901.7337.76112.6Research diagnostic criteria: rationale and reliability. R L Spitzer, J Endicott, E RobinsArch Gen Psychiatry1978655775Yes
125319011901.054.1154.1In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. T R ChenExp Cell Res197765285Yes
125418991899.054.2754.3The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. G P ChrousosN Engl J Med19957715646No
125518991899.00.00.0The oxidation of ribonuclease with performic acid. C H HirsJ Biol Chem195613319283Yes
125618981898.024.8124.8A theory of cerebellar cortex. D MarrJ Physiol19695784296Yes
125737901895.089.0644.5Neuronal oscillations in cortical networks. György Buzsáki, Andreas DraguhnScience200415218136No
125818941894.069.9169.9Pro-resolving lipid mediators are leads for resolution physiology. Charles N SerhanNature201424899309No
125918931893.059.9760.0The Gingival Index, the Plaque Index and the Retention Index Systems. H LöeJ Periodontol19675237684Yes
126037861893.0111.8455.9Mechanisms of salinity tolerance. Rana Munns, Mark TesterAnnu Rev Plant Biol200818444910No
126137851892.586.4843.2The Fas death factor. S Nagata, P GolsteinScience19957533326No
126218921892.046.7846.8Pathogen recognition and inflammatory signaling in innate immune defenses. Trine H MogensenClin Microbiol Rev200919366914No
126337811890.5112.0456.0Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. James J Gross, Oliver P JohnJ Pers Soc Psychol200312916575Yes
126418901890.040.9741.0The mitogen-activated protein kinase signal transduction pathway. R J DavisJ Biol Chem19938325833No
126518891889.017.5917.6Positional information and the spatial pattern of cellular differentiation. L WolpertJ Theor Biol19694390734Yes
126618881888.059.4959.5Complete nucleotide sequence of the Escherichia coli plasmid pBR322. J G SutcliffeCold Spring Harb Symp Quant Biol1979383387Yes
126737761888.0134.5267.3ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. M Gardes, T D BrunsMol Ecol19938180733Yes
126837751887.5112.2556.1An efficient mRNA-dependent translation system from reticulocyte lysates. H R Pelham, R J JacksonEur J Biochem1976823012Yes
126937751887.584.942.5Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. T Miyashita, J C ReedCell19957834749Yes
127037731886.5130.6865.3PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. Daniel R Roe, Thomas E CheathamJ Chem Theory Comput201326583988Yes
127137711885.5132.7166.4Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. Sarvajeet Singh Gill, Narendra TutejaPlant Physiol Biochem201020870416No
127218851885.043.1443.1Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Jeffrey A EngelmanNat Rev Cancer200919629070No
127337681884.084.0142.0Parkinson's disease: mechanisms and models. William Dauer, Serge PrzedborskiNeuron200312971891No
127437661883.0128.4864.2Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. M H Zweig, G CampbellClin Chem19938472349No
127537601880.089.6244.8The future of genetic studies of complex human diseases. N Risch, K MerikangasScience19968801636Yes
1276206741879.5516.1946.9PLINK: a tool set for whole-genome association and population-based linkage analyses. Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C ShamAm J Hum Genet200717701901Yes
127718781878.051.0851.1A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. P J GoodfordJ Med Chem19853892003Yes
127818781878.064.0264.0Guided Search 2.0 A revised model of visual search. J M WolfePsychon Bull Rev199424203471Yes
127937541877.0126.7463.4Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. G Di Chiara, A ImperatoProc Natl Acad Sci U S A19882899326Yes
128018761876.086.9286.9A simple fluorometric assay for lipoperoxide in blood plasma. K YagiBiochem Med1976962904Yes
128118751875.041.9642.0The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Michael R LieberAnnu Rev Biochem201020192759No
128256241874.7143.948.0Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. G S Hotamisligil, N S Shargill, B M SpiegelmanScience19937678183Yes
128318741874.00.00.0Dendritic organization in the neurons of the visual and motor cortices of the cat. D A ShollJ Anat195313117757Yes
128418741874.045.145.1The genetics of ageing. Cynthia J KenyonNature201020336132No
128518741874.058.8858.9Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Berislav V ZlokovicNat Rev Neurosci201122048062No
128618731873.041.2241.2Cellular mechanisms of insulin resistance. G I ShulmanJ Clin Invest200010903330No
128718721872.069.2369.2Recognition-by-components: a theory of human image understanding. Irving BiedermanPsychol Rev19873575582Yes
128818721872.039.9740.0Exploring complex networks. S H StrogatzNature200111258382No
128974861871.5252.0663.0Reporting results of cancer treatment. A B Miller, B Hoogstraten, M Staquet, A WinklerCancer19817459811Yes
129018711871.052.7552.8Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. A DunaifEndocr Rev19979408743No
129137401870.0105.8552.9Event-related EEG/MEG synchronization and desynchronization: basic principles. G Pfurtscheller, F H Lopes da SilvaClin Neurophysiol199910576479No
129218681868.068.468.4Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. D R JaneroFree Radic Biol Med19902079232No
129337361868.079.239.6Raster3D: photorealistic molecular graphics. E A Merritt, D J BaconMethods Enzymol199718488322Yes
129474661866.5184.0146.0Epithelial-mesenchymal transitions in development and disease. Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela NietoCell200919945376No
129518661866.045.0545.0Python: a programming language for software integration and development. M F SannerJ Mol Graph Model199910660911Yes
129618661866.041.7641.8Fabrication of novel biomaterials through molecular self-assembly. Shuguang ZhangNat Biotechnol200314520402No
129718641864.053.3753.4Multiple imputation: a primer. J L SchaferStat Methods Med Res199910347857No
129855911863.7125.4241.8A new statistical method for haplotype reconstruction from population data. M Stephens, N J Smith, P DonnellyAm J Hum Genet200111254454Yes
1299148841860.5363.8345.5Electric field effect in atomically thin carbon films. K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A FirsovScience200415499015Yes
130055811860.3241.7780.6Scoping studies: advancing the methodology. Danielle Levac, Heather Colquhoun, Kelly K O'BrienImplement Sci201020854677Yes
130118601860.045.0545.0The hydrogen bond in the solid state. Thomas SteinerAngew Chem Int Ed Engl200212491444Yes
130218591859.037.4137.4Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. R J KaufmanGenes Dev199910346810No
130318581858.048.6348.6Hepatitis B virus infection. W M LeeN Engl J Med19979392700No
130418581858.051.751.7Cell biology and molecular basis of denitrification. W G ZumftMicrobiol Mol Biol Rev19979409151No
130518561856.053.7253.7Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. D M NevilleJ Biol Chem19715127429Yes
130637111855.567.8133.9Rho GTPases in cell biology. Sandrine Etienne-Manneville, Alan HallNature200212478284No
1307129871855.3463.2666.2Assessing the quality of reports of randomized clinical trials: is blinding necessary? A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuayControl Clin Trials19968721797Yes
130837061853.0103.2951.6Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. R L Heath, L PackerArch Biochem Biophys19685655425Yes
130955571852.3138.8646.3Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Z N Oltvai, C L Milliman, S J KorsmeyerCell19938358790Yes
131018521852.042.9543.0The retinal pigment epithelium in visual function. Olaf StraussPhysiol Rev200515987797No
131137021851.076.5438.3Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. C D Nobes, A HallCell19957536630Yes
131236971848.538.3319.2Immunoassay of insulin with insulin-antibody precipitate. C N Hales, P J RandleBiochem J196313952078Yes
131318481848.041.9742.0Protein denaturation. C TanfordAdv Protein Chem19684882248No
131418471847.049.2949.3Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. Robert E MarxJ Oral Maxillofac Surg200312966493Yes
1315147691846.1415.8952.0Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A ErlichScience19882448875Yes
131618461846.077.3977.4The drug abuse screening test. H A SkinnerAddict Behav19827183189Yes
131755371845.7118.9539.6A rapid method for the isolation of functional thymus-derived murine lymphocytes. M H Julius, E Simpson, L A HerzenbergEur J Immunol19734587740Yes
131818451845.055.855.8The atom economy--a search for synthetic efficiency. B M TrostScience19911962206Yes
131918451845.048.7148.7The comet assay for DNA damage and repair: principles, applications, and limitations. Andrew R CollinsMol Biotechnol200415004294No
132018441844.041.7641.8Integrating cell-signalling pathways with NF-kappaB and IKK function. Neil D PerkinsNat Rev Mol Cell Biol200717183360No
132118431843.041.7141.7DNA topoisomerases. J C WangAnnu Rev Biochem19968811192No
132218431843.041.4241.4Global cancer statistics in the year 2000. D M ParkinLancet Oncol200111905707No
132336841842.077.9939.0Monocyte and macrophage heterogeneity. Siamon Gordon, Philip R TaylorNat Rev Immunol200516322748No
132436811840.5112.456.2Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Stephen M Smith, Thomas E NicholsNeuroimage200918501637Yes
132518401840.068.3568.3Physiological aspects of primary hypertension. B FolkowPhysiol Rev19826461865No
132618401840.066.2266.2Why patients use alternative medicine: results of a national study. J A AstinJAMA19989605899Yes
132773581839.5178.1144.5Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. A Shevchenko, M Wilm, O Vorm, M MannAnal Chem19968779443Yes
132818391839.044.6944.7Evolutionary relationship of DNA sequences in finite populations. F TajimaGenetics19836628982Yes
132936781839.076.5238.3Identification of common molecular subsequences. T F Smith, M S WatermanJ Mol Biol19817265238Yes
133018391839.043.5743.6The mitochondrial permeability transition pore and its role in cell death. M CromptonBiochem J199910393078No
133173551838.8337.2184.3Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. D J Sahn, A DeMaria, J Kisslo, A WeymanCirculation1978709763Yes
133236741837.0115.4957.7Understanding interobserver agreement: the kappa statistic. Anthony J Viera, Joanne M GarrettFam Med200515883903Yes
133336731836.5120.460.2Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. R A DeFronzo, E FerranniniDiabetes Care19912044434No
133418361836.054.2154.2An overview of brominated flame retardants in the environment. Cynthia A de WitChemosphere200211999784No
133518351835.0113.03113.0Understanding Bland Altman analysis. Davide GiavarinaBiochem Med (Zagreb)201526110027No
133655001833.3121.7240.6Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Michael W Pfaffl, Graham W Horgan, Leo DempfleNucleic Acids Res200211972351Yes
1337109841830.7605.94101.0DADA2: High-resolution sample inference from Illumina amplicon data. Benjamin J Callahan, Paul J McMurdie, Michael J Rosen, Andrew W Han, Amy Jo A Johnson, Susan P HolmesNat Methods201627214047Yes
133818301830.045.0245.0Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Fiona TurnbullLancet200314615107Yes
133991471829.4218.7643.8Mapping and quantifying mammalian transcriptomes by RNA-Seq. Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara WoldNat Methods200818516045Yes
134073171829.22329.74582.4Cancer statistics, 2022. Rebecca L Siegel, Kimberly D Miller, Hannah E Fuchs, Ahmedin JemalCA Cancer J Clin202235020204Yes
134118291829.00.00.0The influence of some cations on an adenosine triphosphatase from peripheral nerves. J C SkouBiochim Biophys Acta195713412736Yes
134218291829.048.3648.4Molecular dissection of reactive astrogliosis and glial scar formation. Michael V SofroniewTrends Neurosci200919782411No
134336531826.5108.0554.0New method for quantitative determination of uronic acids. N Blumenkrantz, G Asboe-HansenAnal Biochem19734269305Yes
134418261826.049.3949.4A classification of hand preference by association analysis. M AnnettBr J Psychol19705457503Yes
134518261826.035.5635.6Cancer and the chemokine network. Fran BalkwillNat Rev Cancer200415229479No
134618261826.036.4536.5MicroRNA biogenesis: coordinated cropping and dicing. V Narry KimNat Rev Mol Cell Biol200515852042No
134718241824.095.6295.6Subjective well-being. E DienerPsychol Bull19846399758No
134818241824.013.0113.0A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. D A RobinsonIEEE Trans Biomed Eng196314121113Yes
134936481824.076.2638.1Cell death: critical control points. Nika N Danial, Stanley J KorsmeyerCell200414744432No
135018231823.050.1450.1Systemic lupus erythematosus. George C TsokosN Engl J Med201122129255No
135136451822.5108.9254.5Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). Kathryn M Connor, Jonathan R T DavidsonDepress Anxiety200312964174Yes
135218211821.059.5959.6Cognitive reserve. Yaakov SternNeuropsychologia200919467352No
135318201820.046.846.8From sensation to cognition. M M MesulamBrain19989648540No
135418181818.083.1683.2Determinants of low birth weight: methodological assessment and meta-analysis. M S KramerBull World Health Organ19873322602No
135536351817.581.240.6Amino acid substitution matrices from protein blocks. S Henikoff, J G HenikoffProc Natl Acad Sci U S A19921438297Yes
135636341817.0127.3563.7Regulation of microRNA biogenesis. Minju Ha, V Narry KimNat Rev Mol Cell Biol201425027649No
135718161816.069.7169.7Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. H U WittchenJ Psychiatr Res19948064641No
135818161816.057.1157.1Matching methods for causal inference: A review and a look forward. Elizabeth A StuartStat Sci201020871802Yes
135936321816.0131.1965.6miRBase: annotating high confidence microRNAs using deep sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201424275495Yes
136018131813.057.9257.9Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. U UngerstedtActa Physiol Scand Suppl19714332693Yes
136136251812.598.5449.3Biofilms: survival mechanisms of clinically relevant microorganisms. Rodney M Donlan, J William CostertonClin Microbiol Rev200211932229No
136218121812.031.8331.8Evolutionary rate at the molecular level. M KimuraNature19685637732Yes
136354331811.0194.7464.9Molecular mechanisms of epithelial-mesenchymal transition. Samy Lamouille, Jian Xu, Rik DerynckNat Rev Mol Cell Biol201424556840No
136418101810.036.7536.8The lasso method for variable selection in the Cox model. R TibshiraniStat Med19979044528Yes
136518081808.048.7948.8New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. R Y TsienBiochemistry19806770893Yes
136618071807.058.9358.9Heavy metal intensification of DAB-based HRP reaction product. J C AdamsJ Histochem Cytochem19817252134Yes
136718071807.036.5636.6Molecular regulation of vessel maturation. Rakesh K JainNat Med200312778167No
136836121806.096.3748.2Variations in the pattern of pubertal changes in boys. W A Marshall, J M TannerArch Dis Child19705440182Yes
136918051805.049.1349.1Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. H LeVineProtein Sci19938453378Yes
137054131804.3102.934.3Surfing the p53 network. B Vogelstein, D Lane, A J LevineNature200011099028No
137136081804.092.3146.2Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. K D McCarthy, J de VellisJ Cell Biol19806248568Yes
137254121804.0245.9882.0Fast and sensitive protein alignment using DIAMOND. Benjamin Buchfink, Chao Xie, Daniel H HusonNat Methods201525402007Yes
137354121804.0481.23160.4An interactive web-based dashboard to track COVID-19 in real time. Ensheng Dong, Hongru Du, Lauren GardnerLancet Infect Dis202032087114Yes
137454071802.3161.2153.7Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Helga Thorvaldsdóttir, James T Robinson, Jill P MesirovBrief Bioinform201322517427Yes
137536031801.5105.1152.6Molecular mechanisms and clinical applications of angiogenesis. Peter Carmeliet, Rakesh K JainNature201121593862No
137617991799.019.7819.8Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. S CohenJ Biol Chem196213880319Yes
137717991799.065.8765.9The Resonating Valence Bond State in La2CuO4 and Superconductivity. P W AndersonScience198717818979Yes
137817981798.036.0636.1The effect of infections on susceptibility to autoimmune and allergic diseases. Jean-Francois BachN Engl J Med200212239261No
137935951797.586.3243.2Protein folding in the cell. M J Gething, J SambrookNature19921731198No
138017971797.056.5256.5Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. M ZasloffProc Natl Acad Sci U S A19873299384Yes
138117971797.067.4567.5Cognitive reserve in ageing and Alzheimer's disease. Yaakov SternLancet Neurol201223079557No
138217961796.00.00.0The measurement of volume changes in human limbs. R J WhitneyJ Physiol195313085295Yes
138317961796.039.7639.8Recognition of microorganisms and activation of the immune response. Ruslan MedzhitovNature200717943118No
138417961796.00.00.0Cognitive maps in rats and men. E C TolmanPsychol Rev194818870876Yes
138535921796.0305.98153.0The biology, function, and biomedical applications of exosomes. Raghu Kalluri, Valerie S LeBleuScience202032029601No
138617951795.098.4398.4Estimability and estimation in case-referent studies. O MiettinenAm J Epidemiol19761251836Yes
138735881794.0159.7279.9Multiple receptors for dopamine. J W Kebabian, D B CalneNature1979215920No
138835851792.587.1943.6Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Christian Haass, Dennis J SelkoeNat Rev Mol Cell Biol200717245412No
138917921792.062.4862.5A cortical network for directed attention and unilateral neglect. M M MesulamAnn Neurol19817032417No
139017921792.051.3551.4Perceptual symbol systems. L W BarsalouBehav Brain Sci199911301525No
139135831791.5178.8889.4Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. M Mihara, M UchiyamaAnal Biochem1978655387Yes
139217911791.069.9770.0Predicting basal metabolic rate, new standards and review of previous work. W N SchofieldHum Nutr Clin Nutr19854044297Yes
139317911791.042.4342.4Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. D LavanchyJ Viral Hepat200414996343No
139417881788.042.242.2Type III protein secretion systems in bacterial pathogens of animals and plants. C J HueckMicrobiol Mol Biol Rev19989618447No
1395107251787.5313.452.2Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939837Yes
139617871787.036.736.7Structure and regulation of voltage-gated Ca2+ channels. W A CatterallAnnu Rev Cell Dev Biol200011031246No
139789331786.6234.246.8Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary KingDiabetes Care200415111519Yes
139817861786.058.458.4The crisis in antibiotic resistance. H C NeuScience19921509257No
139917861786.043.2343.2Integration, scaling, space-group assignment and post-refinement. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124693Yes
140035691784.599.0149.5EQ-5D: a measure of health status from the EuroQol Group. R Rabin, F de CharroAnn Med200111491192No
140135671783.586.5243.3Maturation of the head of bacteriophage T4. I. DNA packaging events. U K Laemmli, M FavreJ Mol Biol19734204102Yes
140271321783.0173.0443.3Improved optimization for the robust and accurate linear registration and motion correction of brain images. Mark Jenkinson, Peter Bannister, Michael Brady, Stephen SmithNeuroimage200212377157Yes
140317831783.048.8748.9Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Ralph A DefronzoDiabetes200919336687No
140435651782.584.8842.4Receptive fields and functional architecture of monkey striate cortex. D H Hubel, T N WieselJ Physiol19684966457Yes
140517821782.039.0439.0Gene finding in novel genomes. Ian KorfBMC Bioinformatics200415144565Yes
140617811781.058.8658.9Large-scale neurocognitive networks and distributed processing for attention, language, and memory. M M MesulamAnn Neurol19902260847No
140717811781.036.0836.1Points of control in inflammation. Carl NathanNature200212490957No
140817801780.047.0847.1Interleukin-6: an overview. J Van SnickAnnu Rev Immunol19902188664No
140917801780.049.4149.4Porous scaffold design for tissue engineering. Scott J HollisterNat Mater200516003400No
141017781778.032.9633.0Cellular roles of DNA topoisomerases: a molecular perspective. James C WangNat Rev Mol Cell Biol200212042765No
141117771777.057.7757.8Pineal melatonin: cell biology of its synthesis and of its physiological interactions. R J ReiterEndocr Rev19911649044No
141217771777.054.1854.2Social relationships and health. Sheldon CohenAm Psychol200415554821No
141353291776.3158.8252.9Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. P A Wolf, R D Abbott, W B KannelStroke19911866765Yes
141453251775.0111.2737.1A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J H Zhang, T D Chung, K R OldenburgJ Biomol Screen199910838414Yes
141570991774.8197.2249.3Comorbidity measures for use with administrative data. A Elixhauser, C Steiner, D R Harris, R M CoffeyMed Care19989431328Yes
141617741774.058.8658.9Drugs of abuse: anatomy, pharmacology and function of reward pathways. G F KoobTrends Pharmacol Sci19921604710No
141717741774.048.548.5Leptospirosis. P N LevettClin Microbiol Rev200111292640No
141817711771.018.7918.8Chromatin structure: a repeating unit of histones and DNA. R D KornbergScience19744825889Yes
141917671767.034.0734.1Transplacental carcinogenesis by stilbestrol. J FolkmanN Engl J Med19715556579Yes
142035341767.088.544.2The biology of vascular endothelial growth factor. N Ferrara, T Davis-SmythEndocr Rev19979034784No
142135331766.5137.7268.9Assays of glutathione peroxidase. L Flohé, W A GünzlerMethods Enzymol19846727659Yes
142217651765.047.8847.9G proteins and dual control of adenylate cyclase. A G GilmanCell19846321035Yes
142317651765.049.3449.3Oxidative stress: oxidants and antioxidants. H SiesExp Physiol19979129943No
142417651765.043.4743.5Adipose tissue, adipokines, and inflammation. Giamila FantuzziJ Allergy Clin Immunol200515867843No
142517651765.042.5342.5Growth of the plant cell wall. Daniel J CosgroveNat Rev Mol Cell Biol200516261190No
142617641764.037.8237.8Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. J N DumontJ Morphol19724109871Yes
142717641764.038.2238.2ATPase activity of myosin correlated with speed of muscle shortening. M BárányJ Gen Physiol19674227924Yes
142817641764.00.00.0A personality scale of manifest anxiety. J A TaylorJ Abnorm Psychol195313052352Yes
142917631763.046.546.5Oxidative stress and neurodegeneration: where are we now? Barry HalliwellJ Neurochem200616805774No
143070511762.8137.6834.4Stem cells, cancer, and cancer stem cells. T Reya, S J Morrison, M F Clarke, I L WeissmanNature200111689955No
143117621762.057.257.2The inverse care law. J T HartLancet19714100731Yes
143217621762.036.0536.0An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. R M EsnoufJ Mol Graph Model19979385560Yes
143317611761.040.1940.2Steroid receptor regulated transcription of specific genes and gene networks. K R YamamotoAnnu Rev Genet19853909942No
143417601760.00.00.0The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. S HestrinJ Biol Chem194918133390Yes
143517601760.047.3347.3What we can do and what we cannot do with fMRI. Nikos K LogothetisNature200818548064No
143617591759.044.844.8The pathophysiology of tumor necrosis factors. P VassalliAnnu Rev Immunol19921590993No
143717591759.061.1761.2The role of hormone receptors and GTP-regulatory proteins in membrane transduction. M RodbellNature19806101906Yes
143835181759.086.6743.3Matrix metalloproteinases. H Nagase, J F WoessnerJ Biol Chem199910419448No
143917571757.048.8548.9Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. M J CasadabanJ Mol Biol1976781293Yes
144017571757.055.2855.3The stress response in fish. S E Wendelaar BongaPhysiol Rev19979234959No
144117571757.035.9536.0Protein homology detection by HMM-HMM comparison. Johannes SödingBioinformatics200515531603Yes
1442175681756.8550.1755.0Measurement of protein using bicinchoninic acid. P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C KlenkAnal Biochem19853843705Yes
144352661755.3138.7446.2Median-joining networks for inferring intraspecific phylogenies. H J Bandelt, P Forster, A RöhlMol Biol Evol199910331250Yes
144417551755.040.7840.8Areas, volumes, packing and protein structure. F M RichardsAnnu Rev Biophys Bioeng1977326146No
144535081754.0108.5254.3Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. F Denizot, R LangJ Immunol Methods19863486233Yes
144635081754.0127.5363.8The need to belong: desire for interpersonal attachments as a fundamental human motivation. R F Baumeister, M R LearyPsychol Bull19957777651No
144717541754.038.8238.8The synaptic vesicle cycle: a cascade of protein-protein interactions. T C SüdhofNature19957791897No
144835061753.049.1324.6A complementation analysis of the restriction and modification of DNA in Escherichia coli. H W Boyer, D Roulland-DussoixJ Mol Biol19694896022Yes
144917531753.044.1444.1Hydrogels for biomedical applications. Allan S HoffmanAdv Drug Deliv Rev200211755703No
145035051752.590.2245.1Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. M A Nitsche, W PaulusJ Physiol200010990547Yes
145117521752.057.557.5Serum albumin. T PetersAdv Protein Chem19853904348No
145217521752.036.4936.5Excitatory actions of gaba during development: the nature of the nurture. Yehezkel Ben-AriNat Rev Neurosci200212209121No
145352511750.3138.7546.2The metabolic syndrome--a new worldwide definition. K George M M Alberti, Paul Zimmet, Jonathan ShawLancet200516182882Yes
1454122491749.9296.3542.3Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M NathanN Engl J Med200211832527Yes
145534991749.592.8146.4Prediction of protein antigenic determinants from amino acid sequences. T P Hopp, K R WoodsProc Natl Acad Sci U S A19816167991Yes
145669981749.5270.0667.5Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanInt J Surg201020171303No
145734991749.5138.7669.4ROS function in redox signaling and oxidative stress. Michael Schieber, Navdeep S ChandelCurr Biol201424845678No
145834971748.595.0147.5Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. K B Mullis, F A FaloonaMethods Enzymol19873431465Yes
145917481748.0107.22107.2Making sense of implementation theories, models and frameworks. Per NilsenImplement Sci201525895742Yes
146017461746.047.0747.1Oxidative stress hypothesis in Alzheimer's disease. W R MarkesberyFree Radic Biol Med19979165306No
146134921746.074.3737.2Insulin signalling and the regulation of glucose and lipid metabolism. A R Saltiel, C R KahnNature200111742412Yes
146217461746.045.8945.9Chlorpromazine equivalent doses for the newer atypical antipsychotics. Scott W WoodsJ Clin Psychiatry200312823080No
146317451745.042.0942.1Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Paul M RidkerCirculation200312551853No
146417441744.054.4754.5Glutamate: a neurotransmitter in mammalian brain. F FonnumJ Neurochem19846139418No
146517431743.071.771.7Dynamic properties of mammalian skeletal muscles. R I ClosePhysiol Rev19724256989No
146634861743.072.9636.5Why do cancers have high aerobic glycolysis? Robert A Gatenby, Robert J GilliesNat Rev Cancer200415516961No
146717431743.038.538.5The hippo signaling pathway in development and cancer. Duojia PanDev Cell201020951342No
146817421742.041.9942.0Why genes in pieces? W GilbertNature1978622185Yes
146917411741.00.00.0The general adaptation syndrome and the diseases of adaptation. H SelyeJ Clin Endocrinol Metab194621025115Yes
147017401740.043.3443.3Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. B Winkel-ShirleyPlant Physiol200111402179No
147117401740.065.9566.0Antibiotics in the aquatic environment--a review--part I. Klaus KümmererChemosphere200919185900No
147217391739.061.7461.7Cyclosporine. B D KahanN Engl J Med19892687689No
147317391739.040.7840.8Solvent-accessible surfaces of proteins and nucleic acids. M L ConnollyScience19836879170Yes
147434771738.5113.9357.0Saliency, switching, attention and control: a network model of insula function. Vinod Menon, Lucina Q UddinBrain Struct Funct201020512370No
147534761738.092.346.1The mirror-neuron system. Giacomo Rizzolatti, Laila CraigheroAnnu Rev Neurosci200415217330No
147634751737.573.0636.5Integrin signaling. F G Giancotti, E RuoslahtiScience199910446041No
147734741737.096.8148.4The precuneus: a review of its functional anatomy and behavioural correlates. Andrea E Cavanna, Michael R TrimbleBrain200616399806No
147834731736.5100.0150.0Alzheimer's disease. Henry W Querfurth, Frank M LaFerlaN Engl J Med201020107219No
147934731736.585.2242.6Macrophage diversity enhances tumor progression and metastasis. Bin-Zhi Qian, Jeffrey W PollardCell201020371344No
148034711735.5122.5961.3The transtheoretical model of health behavior change. J O Prochaska, W F VelicerAm J Health Promot199710170434No
148117351735.031.4831.5CD4+ CD25+ suppressor T cells: more questions than answers. Ethan M ShevachNat Rev Immunol200212093005No
148234681734.091.0245.5Cloned glutamate receptors. M Hollmann, S HeinemannAnnu Rev Neurosci19948210177No
148317341734.058.758.7Functional and effective connectivity: a review. Karl J FristonBrain Connect201122432952No
148469351733.8135.5433.9Transformation of intact yeast cells treated with alkali cations. H Ito, Y Fukuda, K Murata, A KimuraJ Bacteriol19836336730Yes
148534671733.5148.5674.3mTOR Signaling in Growth, Metabolism, and Disease. Robert A Saxton, David M SabatiniCell201728283069No
148652001733.3112.6837.6Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. A Nicholls, K A Sharp, B HonigProteins19911758883Yes
148717331733.041.0641.1Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. A KrishanJ Cell Biol197549354Yes
148817321732.059.4859.5Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? B HalliwellLancet19947915779No
148917311731.064.7264.7Simple proton spectroscopic imaging. W T DixonRadiology19846089263Yes
149017301730.038.3538.4Mode of cell migration to the superficial layers of fetal monkey neocortex. P RakicJ Comp Neurol19724624784Yes
149117301730.035.4135.4Oxidative stress shortens telomeres. Thomas von ZglinickiTrends Biochem Sci200212114022Yes
149217301730.0112.96113.0Toward understanding the origin and evolution of cellular organisms. Minoru KanehisaProtein Sci201931441146No
149334591729.5123.9362.0Pain assessment: global use of the Brief Pain Inventory. C S Cleeland, K M RyanAnn Acad Med Singap19948080219No
149434581729.079.9140.0The incidence of congenital heart disease. Julien I E Hoffman, Samuel KaplanJ Am Coll Cardiol200212084585No
149517281728.060.7660.8Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. M Wong-RileyBrain Res1979223730Yes
149617281728.037.5537.5Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. A F HabeebAnal Biochem19664161471Yes
149734541727.082.6141.3Origins and Mechanisms of miRNAs and siRNAs. Richard W Carthew, Erik J SontheimerCell200919239886No
149817261726.049.849.8Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. E M WassermannElectroencephalogr Clin Neurophysiol19989474057No
149934511725.5177.0688.5Interrater reliability of a modified Ashworth scale of muscle spasticity. R W Bohannon, M B SmithPhys Ther19873809245Yes
150034491724.578.8339.4Shared principles in NF-kappaB signaling. Matthew S Hayden, Sankar GhoshCell200818267068No
150117221722.064.7664.8Modeling and variable selection in epidemiologic analysis. S GreenlandAm J Public Health19892916724Yes
150217221722.043.9343.9The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. R RossJ Cell Biol19714327464Yes
150334441722.0118.4859.2The Oswestry Disability Index. J C Fairbank, P B PynsentSpine (Phila Pa 1976)200011074683No
150417211721.00.00.0The recurrence of intracranial meningiomas after surgical treatment. D SimpsonJ Neurol Neurosurg Psychiatry195713406590Yes
150534411720.5109.0954.5Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Jennifer A Doudna, Emmanuelle CharpentierScience201425430774No
150617201720.055.7855.8Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. E M WitkinBacteriol Rev1976795416No
150751601720.0230.0776.7Some statistical methods useful in circulation research. S Wallenstein, C L Zucker, J L FleissCirc Res19807379260Yes
150817181718.042.742.7Cellular basis of working memory. P S Goldman-RakicNeuron19957695894No
150951541718.0116.7238.9Inflammation and atherosclerosis. Peter Libby, Paul M Ridker, Attilio MaseriCirculation200211877368No
151017171717.033.4133.4Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Judith CampisiCell200515734683No
151151491716.3161.1453.7Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. H Esterbauer, R J Schaur, H ZollnerFree Radic Biol Med19911937131No
151217161716.059.3959.4Falls in older people: epidemiology, risk factors and strategies for prevention. Laurence Z RubensteinAge Ageing200616926202No
151334321716.087.1443.6Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. Steven E Nissen, Kathy WolskiN Engl J Med200717517853Yes
151417131713.044.5944.6Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. G C WalkerMicrobiol Rev19846371470No
151517131713.056.9156.9Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. C E MogensenN Engl J Med19846690964Yes
151634261713.086.3243.2Quantum dot bioconjugates for ultrasensitive nonisotopic detection. W C Chan, S NieScience19989748158Yes
151734241712.081.1240.6The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. A E Bolton, W M HunterBiochem J19734733239Yes
151817121712.051.8551.9Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. F RoussetGenetics19979093870Yes
151917121712.040.940.9Tricine-SDS-PAGE. Hermann SchäggerNat Protoc200617406207Yes
152017121712.039.0839.1Tumor angiogenesis. Robert S KerbelN Engl J Med200818463380No
152134231711.5124.5962.3The integrative review: updated methodology. Robin Whittemore, Kathleen KnaflJ Adv Nurs200516268861Yes
1522102681711.3311.952.0New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier GascuelSyst Biol201020525638Yes
152317111711.036.0536.0Maintenance of C. elegans. Theresa StiernagleWormBook200618050451No
152417111711.051.6151.6Aging, cellular senescence, and cancer. Judith CampisiAnnu Rev Physiol201323140366No
152517111711.073.3673.4Optical properties of biological tissues: a review. Steven L JacquesPhys Med Biol201323666068No
152634211710.50.00.0Convergent and discriminant validation by the multitrait-multimethod matrix. D T Campbell, D W FiskePsychol Bull195913634291Yes
152734211710.5114.3557.2A "Direct-Coloring" Thiocholine Method For Cholinesterases. M J Karnovsky, L RootsJ Histochem Cytochem196414187330Yes
152817101710.0117.96118.0High-performance medicine: the convergence of human and artificial intelligence. Eric J TopolNat Med201930617339No
152934191709.5147.1473.6A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. J G Snodgrass, M VanderwartJ Exp Psychol Hum Learn19807373248Yes
153017091709.031.6631.7How eukaryotic transcriptional activators work. M PtashneNature19883050531No
153117091709.038.5638.6Effects of cytochalasin and phalloidin on actin. J A CooperJ Cell Biol19873312229No
153251271709.0138.8846.3trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. Salvador Capella-Gutiérrez, José M Silla-Martínez, Toni GabaldónBioinformatics200919505945Yes
153317081708.00.00.0Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. J SpizizenProc Natl Acad Sci U S A195816590310Yes
153417081708.057.457.4Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. Lutz AckermannChem Rev201121391562Yes
153534151707.5145.5972.8A fluorometric method for determination of oxidized and reduced glutathione in tissues. P J Hissin, R HilfAnal Biochem1976962076Yes
153617071707.059.5959.6Computerized transverse axial scanning (tomography). 1. Description of system. G N HounsfieldBr J Radiol19734757352Yes
153717071707.032.3932.4Network motifs: theory and experimental approaches. Uri AlonNat Rev Genet200717510665No
153817061706.040.440.4The relationship between the spleen colony-forming cell and the haemopoietic stem cell. R SchofieldBlood Cells1978747780Yes
153968151703.8140.4735.1Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. E A Jaffe, R L Nachman, C G Becker, C R MinickJ Clin Invest19734355998Yes
154017031703.052.0852.1A measure of population subdivision based on microsatellite allele frequencies. M SlatkinGenetics19957705646Yes
154134061703.073.6236.8Fibroblasts in cancer. Raghu Kalluri, Michael ZeisbergNat Rev Cancer200616572188No
154234051702.5129.6164.8The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. A J Stunkard, S MessickJ Psychosom Res19853981480Yes
154317021702.045.5345.5Integrins. E RuoslahtiJ Clin Invest19911985087No
154417011701.041.4741.5Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. Z YangJ Mol Evol19947932792Yes
1545170071700.7539.7654.0The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S LuthraArthritis Rheum19883358796Yes
154633991699.593.8346.9Biochemistry of multidrug resistance mediated by the multidrug transporter. M M Gottesman, I PastanAnnu Rev Biochem19938102521No
154716991699.075.9776.0The micronucleus test. W SchmidMutat Res197548190Yes
154816991699.043.2143.2Carbonic anhydrase: chemistry, physiology, and inhibition. T H MarenPhysiol Rev19674964060No
154916991699.038.9338.9A graphic method for the determination and presentation of binding parameters in a complex system. H E RosenthalAnal Biochem19676048188Yes
155016981698.038.3438.3Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. S A BustinJ Mol Endocrinol200212200227No
155133961698.0151.5575.8Cancer immunotherapy using checkpoint blockade. Antoni Ribas, Jedd D WolchokScience201829567705No
155267921698.0370.7892.7fastp: an ultra-fast all-in-one FASTQ preprocessor. Shifu Chen, Yanqing Zhou, Yaru Chen, Jia GuBioinformatics201830423086Yes
155316971697.041.2741.3The statistical analysis of enzyme kinetic data. W W ClelandAdv Enzymol Relat Areas Mol Biol19674881884No
155416971697.033.533.5The synaptic vesicle cycle. Thomas C SudhofAnnu Rev Neurosci200415217342No
155516971697.065.7265.7Selenium and human health. Margaret P RaymanLancet201222381456No
155633931696.5110.8155.4Role of free radicals and catalytic metal ions in human disease: an overview. B Halliwell, J M GutteridgeMethods Enzymol19902172697No
155716961696.054.8954.9Validation of a decisional conflict scale. A M O'ConnorMed Decis Making19957898294Yes
155816961696.044.8844.9THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. Kozi AsadaAnnu Rev Plant Physiol Plant Mol Biol199915012221Yes
155916961696.055.6155.6The polyvagal perspective. Stephen W PorgesBiol Psychol200717049418No
156016961696.069.2669.3Whatever next? Predictive brains, situated agents, and the future of cognitive science. Andy ClarkBehav Brain Sci201323663408No
156116951695.040.7940.8The molecular genetics of cancer. J M BishopScience19873541204No
156233881694.0135.3467.7Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. A Y Finlay, G K KhanClin Exp Dermatol19948033378Yes
156384651693.0192.6538.5Stages of embryonic development of the zebrafish. C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F SchillingDev Dyn19958589427Yes
156433841692.0109.1754.6Separate visual pathways for perception and action. M A Goodale, A D MilnerTrends Neurosci19921374953No
156584601692.0209.6841.9Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan HsuN Engl J Med200415385656Yes
156616911691.037.2237.2AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. D Grahame HardieNat Rev Mol Cell Biol200717712357No
1567101441690.7284.2747.4Positional cloning of the mouse obese gene and its human homologue. Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M FriedmanNature19947984236Yes
156816901690.068.2968.3Negative symptoms in schizophrenia. Definition and reliability. N C AndreasenArch Gen Psychiatry19827165477Yes
156916901690.010.2810.3Chromatographic Separation Of Human Brain Gangliosides. L SvennerholmJ Neurochem196314066623Yes
157016891689.036.1236.1Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. S L FriedmanJ Biol Chem200010644669No
157167561689.0443.54110.9Rayyan-a web and mobile app for systematic reviews. Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz, Ahmed ElmagarmidSyst Rev201627919275Yes
157216881688.036.6536.6Trastuzumab--mechanism of action and use in clinical practice. Clifford A HudisN Engl J Med200717611206No
157350641688.0111.7537.2An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J K Eng, A L McCormack, J R YatesJ Am Soc Mass Spectrom199424226387Yes
157416871687.069.2469.2Adverse health effects of high-effort/low-reward conditions. J SiegristJ Occup Health Psychol19969547031No
157533741687.078.7339.4The BCL-2 protein family: opposing activities that mediate cell death. Richard J Youle, Andreas StrasserNat Rev Mol Cell Biol200818097445No
157616861686.039.7539.8Angiogenesis: an organizing principle for drug discovery? Judah FolkmanNat Rev Drug Discov200717396134No
157716851685.032.432.4Generating samples under a Wright-Fisher neutral model of genetic variation. Richard R HudsonBioinformatics200211847089Yes
157833701685.094.0247.0Protective and pathogenic functions of macrophage subsets. Peter J Murray, Thomas A WynnNat Rev Immunol201121997792No
157916841684.060.0360.0Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). G G GlennerN Engl J Med19806154243No
158016841684.031.0731.1Cyclin-dependent kinases: engines, clocks, and microprocessors. D O MorganAnnu Rev Cell Dev Biol19979442875No
158133651682.584.0542.0Protein structure prediction on the Web: a case study using the Phyre server. Lawrence A Kelley, Michael J E SternbergNat Protoc200919247286Yes
158216821682.050.7750.8Constructions of masculinity and their influence on men's well-being: a theory of gender and health. W H CourtenaySoc Sci Med200010741575No
158333641682.0156.378.2The amyloid hypothesis of Alzheimer's disease at 25 years. Dennis J Selkoe, John HardyEMBO Mol Med201627025652No
158433641682.0251.93126.0Interactive Tree Of Life (iTOL) v4: recent updates and new developments. Ivica Letunic, Peer BorkNucleic Acids Res201930931475Yes
1585134491681.1569.0771.1The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jörg Peplies, Frank Oliver GlöcknerNucleic Acids Res201323193283Yes
158616811681.063.1663.2Paced auditory serial-addition task: a measure of recovery from concussion. D M GronwallPercept Mot Skills1977866038Yes
158716811681.038.7538.8The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. D M KingsleyGenes Dev19948299934No
158816811681.047.2847.3The in vitro micronucleus technique. M FenechMutat Res200011113469No
158933611680.5101.8450.9The pathogenesis of rheumatoid arthritis. Iain B McInnes, Georg SchettN Engl J Med201122150039No
159033601680.087.7443.9Multiple sclerosis. Alastair Compston, Alasdair ColesLancet200818970977Yes
159167161679.0283.8471.0An inventory for measuring clinical anxiety: psychometric properties. A T Beck, N Epstein, G Brown, R A SteerJ Consult Clin Psychol19883204199Yes
159216791679.049.5349.5Pedigrees of some mutant strains of Escherichia coli K-12. B J BachmannBacteriol Rev19724568763No
159316791679.032.9332.9Hox genes in vertebrate development. R KrumlaufCell19947913880No
159433581679.080.4840.2CAP3: A DNA sequence assembly program. X Huang, A MadanGenome Res199910508846Yes
159550351678.3129.7843.3The rapid generation of mutation data matrices from protein sequences. D T Jones, W R Taylor, J M ThorntonComput Appl Biosci19921633570Yes
159633551677.571.8135.9The epigenomics of cancer. Peter A Jones, Stephen B BaylinCell200717320506No
159733541677.066.6733.3An automated method for finding molecular complexes in large protein interaction networks. Gary D Bader, Christopher W V HogueBMC Bioinformatics200312525261Yes
159833521676.053.6326.8Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. J Marmur, P DotyJ Mol Biol196214470099Yes
159983791675.8320.1864.0UCHIME improves sensitivity and speed of chimera detection. Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob KnightBioinformatics201121700674Yes
160050241674.7119.6339.9Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Prateek Kumar, Steven Henikoff, Pauline C NgNat Protoc200919561590Yes
160150231674.3108.8836.3Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. J E Darnell, I M Kerr, G R StarkScience19948197455No
160216741674.038.9939.0A revolution in optical manipulation. David G GrierNature200312917694No
160316741674.00.00.0The theory and applications of the exchange of inert gas at the lungs and tissues. S S KetyPharmacol Rev195114833874Yes
160416731673.049.0249.0Drugs which inhibit prostaglandin biosynthesis. R J FlowerPharmacol Rev19744208101Yes
160516721672.053.9854.0Synaptic density in human frontal cortex - developmental changes and effects of aging. P R HuttenlocherBrain Res1979427544Yes
160616721672.058.1358.1Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. A H ConneyCancer Res19826814745No
160716721672.018.3818.4Impulses and Physiological States in Theoretical Models of Nerve Membrane. R FitzhughBiophys J196119431309Yes
160816711671.039.8639.9Inflammatory bowel disease: etiology and pathogenesis. C FiocchiGastroenterology19989649475No
160916711671.038.3938.4NADPH oxidase: an update. B M BabiorBlood199910029572No
161033421671.067.0233.5A guided tour into subcellular colocalization analysis in light microscopy. S Bolte, F P CordelièresJ Microsc200617210054Yes
161116711671.036.6436.6Perceptions of epigenetics. Adrian BirdNature200717522671Yes
161266841671.0224.8256.2SignalP 4.0: discriminating signal peptides from transmembrane regions. Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik NielsenNat Methods201121959131Yes
161316701670.052.8352.8Metallothionein. D H HamerAnnu Rev Biochem19863527054No
161416701670.034.0934.1Neurotrophins and their receptors: a convergence point for many signalling pathways. Moses V ChaoNat Rev Neurosci200312671646No
161550091669.7131.1443.7A neural substrate of prediction and reward. W Schultz, P Dayan, P R MontagueScience19979054347No
161633391669.569.5634.8A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. D Wessel, U I FlüggeAnal Biochem19846731838Yes
161733391669.578.2539.1Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Robert Visse, Hideaki NagaseCirc Res200312730128No
161816691669.026.9827.0RNA-dependent DNA polymerase in virions of RNA tumour viruses. D BaltimoreNature19704316300Yes
161916691669.050.3350.3Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. J A MillerCancer Res19704915745No
162033361668.078.9739.5The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. P Angel, M KarinBiochim Biophys Acta19911751545No
162116681668.067.2967.3Plastic Embedding Mixtures For Use In Electron Microscopy. H H MollenhauerStain Technol196414127791Yes
162233331666.582.7641.4Receptors for purines and pyrimidines. V Ralevic, G BurnstockPharmacol Rev19989755289No
162316661666.00.00.0Method for the determination of hexosamines in tissues. N F BoasJ Biol Chem195313117829Yes
162416661666.038.438.4PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. Michael F. ThomashowAnnu Rev Plant Physiol Plant Mol Biol199915012220Yes
162516651665.032.3432.3Cell cycle checkpoints: preventing an identity crisis. S J ElledgeScience19968939848No
162616651665.049.5549.5phangorn: phylogenetic analysis in R. Klaus Peter SchliepBioinformatics201121169378Yes
162783251665.0282.9556.6The hallmarks of aging. Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido KroemerCell201323746838No
162833281664.088.0344.0Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis). S M Rogers, L BernatchezMol Ecol200515660930Yes
1629116451663.6348.6249.8AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J OlsonJ Comput Chem200919399780Yes
163066541663.5191.4847.9The validity of the Hospital Anxiety and Depression Scale. An updated literature review. Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag NeckelmannJ Psychosom Res200211832252No
163133261663.083.7341.9Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. S Schulman, C KearonJ Thromb Haemost200515842354Yes
163233251662.584.142.0Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. M Grunstein, D S HognessProc Natl Acad Sci U S A19751105573Yes
163349871662.3163.6754.6A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. J R Le Gall, S Lemeshow, F SaulnierJAMA19938254858Yes
163416621662.047.0247.0The many roles for fluorine in medicinal chemistry. William K HagmannJ Med Chem200818570365Yes
163516621662.052.852.8Receiver operating characteristic curve in diagnostic test assessment. Jayawant N MandrekarJ Thorac Oncol201020736804No
163666431660.8152.8238.2Use of T7 RNA polymerase to direct expression of cloned genes. F W Studier, A H Rosenberg, J J Dunn, J W DubendorffMethods Enzymol19902199796Yes
163749821660.7262.2387.4Impact of Event Scale: a measure of subjective stress. M Horowitz, N Wilner, W AlvarezPsychosom Med1979472086Yes
163816601660.048.8548.9Classification of inflammatory bowel disease. J E Lennard-JonesScand J Gastroenterol Suppl19892617184Yes
163933201660.097.3648.7An information-maximization approach to blind separation and blind deconvolution. A J Bell, T J SejnowskiNeural Comput19957584893Yes
164033191659.5218.02109.0The structure of coping. L I Pearlin, C SchoolerJ Health Soc Behav1978649936Yes
164116581658.054.754.7Number of people with glaucoma worldwide. H A QuigleyBr J Ophthalmol19968695555No
164216581658.045.5345.5The origins of the developmental origins theory. D J P BarkerJ Intern Med200717444880No
164366281657.0190.8647.7Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. B Biswal, F Z Yetkin, V M Haughton, J S HydeMagn Reson Med19958524021Yes
164416571657.036.0336.0The NCI60 human tumour cell line anticancer drug screen. Robert H ShoemakerNat Rev Cancer200616990858No
164533131656.558.6829.3Method for the isolation of intact islets of Langerhans from the rat pancreas. P E Lacy, M KostianovskyDiabetes19675333500Yes
1646115941656.3389.455.6GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J SchünemannBMJ200818436948Yes
164749681656.0196.3365.4The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. C A McHorney, J E Ware, A E RaczekMed Care19938450681Yes
164899361656.0202.8133.8Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C MelloNature19989486653Yes
164933101655.094.3147.2Astrocytes: biology and pathology. Michael V Sofroniew, Harry V VintersActa Neuropathol201020012068No
165033091654.586.7243.4Regulation of chromatin by histone modifications. Andrew J Bannister, Tony KouzaridesCell Res201121321607No
165116541654.047.3247.3Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. James J P StewartJ Mol Model200717828561Yes
165282691653.865.6913.1Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. S Katz, A B Ford, R W Moskowitz, B A Jackson, M W JaffeJAMA196314044222Yes
165316521652.033.4133.4DNA in a material world. Nadrian C SeemanNature200312540916No
165416521652.046.6746.7Semiempirical hybrid density functional with perturbative second-order correlation. Stefan GrimmeJ Chem Phys200616438568Yes
165516521652.052.5952.6Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Joseph J VolpeLancet Neurol200919081519No
165616511651.041.8441.8Neurotrophins and neuronal plasticity. H ThoenenScience19957570017No
165733021651.0123.2961.6The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. T Omura, R SatoJ Biol Chem196414209972Yes
165816511651.037.0237.0Introduction to NF-kappaB: players, pathways, perspectives. T D GilmoreOncogene200617072321No
165932991649.5335.96168.0WHO Declares COVID-19 a Pandemic. Domenico Cucinotta, Maurizio VanelliActa Biomed202032191675Yes
166016491649.080.8280.8Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. K O FagerströmAddict Behav1978735910Yes
166116491649.044.3644.4An improved procedure for serum creatine phosphokinase determination. S B RosalkiJ Lab Clin Med19674381359Yes
166216491649.031.2231.2Switching and signaling at the telomere. E H BlackburnCell200111572773No
166316481648.042.7342.7Alpha-crystallin can function as a molecular chaperone. J HorwitzProc Natl Acad Sci U S A19921438232Yes
166416481648.039.0339.0Two pathogenetic types of endometrial carcinoma. J V BokhmanGynecol Oncol19836822361Yes
166516481648.043.8943.9Synergy, antagonism, and what the chequerboard puts between them. F C OddsJ Antimicrob Chemother200312805255No
166632951647.5122.8561.4The mini-mental state examination: a comprehensive review. T N Tombaugh, N J McIntyreJ Am Geriatr Soc19921512391No
166765901647.5260.9565.216S ribosomal DNA amplification for phylogenetic study. W G Weisburg, S M Barns, D A Pelletier, D J LaneJ Bacteriol19911987160Yes
166816471647.065.8865.9Sample size in qualitative research. M SandelowskiRes Nurs Health19957899572Yes
166932931646.5106.7653.4Neurocircuitry of addiction. George F Koob, Nora D VolkowNeuropsychopharmacology201019710631No
167016461646.045.5145.5Turnover of inositol phospholipids and signal transduction. Y NishizukaScience19846147898No
167116451645.040.5140.5A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. D MattinglyJ Clin Pathol196214471419Yes
167216451645.00.00.0Note on the sampling error of the difference between correlated proportions or percentages. Q McNEMARPsychometrika194720254758Yes
167316431643.040.4740.5Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Shitij KapurAm J Psychiatry200312505794No
167432851642.566.5333.3Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Gary L Johnson, Razvan LapadatScience200212471242No
167516421642.067.3567.3A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. D J SchuirmannJ Pharmacokinet Biopharm19873450848Yes
167632831641.571.1335.6Protein structure comparison by alignment of distance matrices. L Holm, C SanderJ Mol Biol19938377180Yes
167716411641.049.0649.1Extracellular ATP: effects, sources and fate. J L GordonBiochem J19863006665No
167816401640.053.7953.8Archaea in coastal marine environments. E F DeLongProc Natl Acad Sci U S A19921608980Yes
167916401640.030.530.5Neuroblastoma: biological insights into a clinical enigma. Garrett M BrodeurNat Rev Cancer200312612655No
168032791639.565.933.0Upstream and downstream of mTOR. Nissim Hay, Nahum SonenbergGenes Dev200415314020No
168116391639.019.5719.6Amino acid difference formula to help explain protein evolution. R GranthamScience19744843792Yes
168216391639.037.4337.4In vivo near-infrared fluorescence imaging. John V FrangioniCurr Opin Chem Biol200314580568No
168332771638.566.3733.2A general framework for weighted gene co-expression network analysis. Bin Zhang, Steve HorvathStat Appl Genet Mol Biol200516646834Yes
168416381638.067.1467.1Responses to depression and their effects on the duration of depressive episodes. S Nolen-HoeksemaJ Abnorm Psychol19911757671No
168516381638.034.7334.7Neuronal calcium signaling. M J BerridgeNeuron19989697848No
168616381638.050.8350.8Stress and disorders of the stress system. George P ChrousosNat Rev Endocrinol200919488073No
168716371637.035.4335.4An approximately unbiased test of phylogenetic tree selection. Hidetoshi ShimodairaSyst Biol200212079646Yes
168816371637.035.5735.6Hematopoietic stem-cell transplantation. Edward A CopelanN Engl J Med200616641398No
168965431635.8202.2450.6The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. S P Baker, B O'Neill, W Haddon, W B LongJ Trauma19744814394Yes
169016351635.023.2223.2Structural considerations in the interaction of DNA and acridines. L S LermanJ Mol Biol196113761054Yes
169132691634.574.7437.4Human mesenchymal stem cells modulate allogeneic immune cell responses. Sudeepta Aggarwal, Mark F PittengerBlood200515494428Yes
169216341634.071.2271.2Neurogenetic adaptive mechanisms in alcoholism. C R CloningerScience19872882604Yes
169316341634.032.3732.4Simple memory: a theory for archicortex. D MarrPhilos Trans R Soc Lond B Biol Sci19714399412Yes
169416341634.058.5158.5Dual-task interference in simple tasks: data and theory. H PashlerPsychol Bull19947972591No
169516341634.038.9739.0The failing heart--an engine out of fuel. Stefan NeubauerN Engl J Med200717360992No
169616341634.052.9352.9The global impact of pre-eclampsia and eclampsia. Lelia DuleySemin Perinatol200919464502No
169716331633.062.5262.5Probiotics in man and animals. R FullerJ Appl Bacteriol19892666378No
169816331633.040.240.2Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. M J MeaneyAnnu Rev Neurosci200111520931No
169916321632.030.5530.6Germinal centers. I C MacLennanAnnu Rev Immunol19948011279No
170032641632.085.442.7Early identification of refractory epilepsy. P Kwan, M J BrodieN Engl J Med200010660394Yes
170132621631.098.8449.4The benefits of being present: mindfulness and its role in psychological well-being. Kirk Warren Brown, Richard M RyanJ Pers Soc Psychol200312703651Yes
170232611630.577.3638.7Adipose tissue as an endocrine organ. Erin E Kershaw, Jeffrey S FlierJ Clin Endocrinol Metab200415181022No
170316301630.058.3158.3Cell damage in the brain: a speculative synthesis. B K SiesjöJ Cereb Blood Flow Metab19816276420No
170416301630.056.4656.5Frontal-subcortical circuits and human behavior. J L CummingsArch Neurol19938352676No
170516301630.034.8734.9Bone morphogenetic proteins: multifunctional regulators of vertebrate development. B L HoganGenes Dev19968682290No
170616301630.029.1629.2Maximum-likelihood density modification. T C TerwilligerActa Crystallogr D Biol Crystallogr200010944333Yes
170716301630.041.6641.7Understanding biofilm resistance to antibacterial agents. David DaviesNat Rev Drug Discov200312563302No
170832591629.582.8641.4ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. Markus Wiederstein, Manfred J SipplNucleic Acids Res200717517781Yes
170932591629.591.0545.5A perspective on cancer cell metastasis. Christine L Chaffer, Robert A WeinbergScience201121436443No
171016281628.049.2449.2Stress signalling pathways that impair prefrontal cortex structure and function. Amy F T ArnstenNat Rev Neurosci200919455173No
171132551627.5211.32105.7A clinical method of functional assessment of the shoulder. C R Constant, A H MurleyClin Orthop Relat Res19873791738Yes
171216271627.00.00.0Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. E G GrayJ Anat195913829103Yes
171316261626.072.4872.5Mood and memory. G H BowerAm Psychol19817224324Yes
171416261626.042.642.6Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. D A DoughertyScience19968539615No
171597551625.8226.5837.8Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuireScience19873798106Yes
171616251625.030.3230.3Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. M G GustafssonJ Microsc200010810003Yes
171716251625.038.4938.5Five rules for the evolution of cooperation. Martin A NowakScience200617158317No
171864971624.2281.2770.3A rating scale for mania: reliability, validity and sensitivity. R C Young, J T Biggs, V E Ziegler, D A MeyerBr J Psychiatry1978728692Yes
171916241624.046.1646.2Fluorescence energy transfer as a spectroscopic ruler. L StryerAnnu Rev Biochem1978354506No
172016241624.050.9250.9Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. D W ChoiTrends Neurosci19882469166No
172116241624.034.334.3The caveolae membrane system. R G AndersonAnnu Rev Biochem19989759488No
172232481624.0129.5764.8The Emerging Hallmarks of Cancer Metabolism. Natalya N Pavlova, Craig B ThompsonCell Metab201626771115No
172332471623.5110.0655.0Neutrophil recruitment and function in health and inflammation. Elzbieta Kolaczkowska, Paul KubesNat Rev Immunol201323435331No
172416231623.033.0933.1Structural features in eukaryotic mRNAs that modulate the initiation of translation. M KozakJ Biol Chem19911939050No
172516231623.046.3246.3The basal ganglia: focused selection and inhibition of competing motor programs. J W MinkProg Neurobiol19969004351No
172616221622.045.345.3Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. B HilleJ Gen Physiol1977300786Yes
172732441622.076.9138.5Rapid and sensitive protein similarity searches. D J Lipman, W R PearsonScience19852983426Yes
172832441622.096.8448.4Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. M Karas, F HillenkampAnal Chem19883239801Yes
172916221622.082.0982.1Hydrogel: Preparation, characterization, and applications: A review. Enas M AhmedJ Adv Res201525750745No
173097201620.0336.3856.1Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R TannenbaumAnal Biochem19827181105Yes
173148591619.795.131.7T-Coffee: A novel method for fast and accurate multiple sequence alignment. C Notredame, D G Higgins, J HeringaJ Mol Biol200010964570Yes
173216191619.047.3347.3Metalloproteinases and their inhibitors in matrix remodeling. L M MatrisianTrends Genet19902132731No
173316191619.058.1958.2The linear-quadratic formula and progress in fractionated radiotherapy. J F FowlerBr J Radiol19892670032No
173416191619.027.7227.7Cell cycle checkpoint signaling through the ATM and ATR kinases. R T AbrahamGenes Dev200111544175No
173516181618.045.6545.6Understanding organofluorine chemistry. An introduction to the C-F bond. David O'HaganChem Soc Rev200818197347No
173616171617.036.9637.0VLA proteins in the integrin family: structures, functions, and their role on leukocytes. M E HemlerAnnu Rev Immunol19902188667No
173732341617.087.5443.8Bronchopulmonary dysplasia. A H Jobe, E BancalariAm J Respir Crit Care Med200111401896No
173816171617.041.1141.1The importance of the ratio of omega-6/omega-3 essential fatty acids. A P SimopoulosBiomed Pharmacother200212442909No
173916171617.00.00.0Discharge patterns and functional organization of mammalian retina. S W KufflerJ Neurophysiol195313035466Yes
174048511617.0206.7468.9The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Susan Michie, Maartje M van Stralen, Robert WestImplement Sci201121513547No
1741129301616.2375.7347.0The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. Ziad S Nasreddine, Natalie A Phillips, Valérie Bédirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard ChertkowJ Am Geriatr Soc200515817019Yes
174216161616.058.7958.8Interhemispheric differences in the localization of psychological processes in man. B MilnerBr Med Bull19714937273No
174332311615.595.4147.7Unified approach for molecular dynamics and density-functional theory. R Car, M ParrinelloPhys Rev Lett198510032153Yes
174416151615.057.8757.9Aging, natural death, and the compression of morbidity. J F FriesN Engl J Med19807383070Yes
174548441614.7146.5848.9Simultaneous inference in general parametric models. Torsten Hothorn, Frank Bretz, Peter WestfallBiom J200818481363No
174616141614.039.3939.4Recognition of errors in three-dimensional structures of proteins. M J SipplProteins19938108378Yes
174716141614.071.5271.5The structure and properties of the sense of coherence scale. A AntonovskySoc Sci Med19938480217Yes
174816131613.036.9336.9Cellular oncogenes and retroviruses. J M BishopAnnu Rev Biochem19836351725No
174916131613.051.0951.1Cellular defenses against damage from reactive oxygen species. B P YuPhysiol Rev19948295932No
175032231611.585.8942.9Molecular mechanisms of long noncoding RNAs. Kevin C Wang, Howard Y ChangMol Cell201121925379No
175116111611.030.530.5Protein kinases--the major drug targets of the twenty-first century? Philip CohenNat Rev Drug Discov200212120282No
175232191609.562.6731.3Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. M E Greenberg, E B ZiffNature19846090941Yes
175332171608.588.7344.4Diarrheagenic Escherichia coli. J P Nataro, J B KaperClin Microbiol Rev19989457432No
175416071607.039.5539.5Tumor necrosis factor (TNF). L J OldScience19852413547Yes
175516061606.00.00.0Cerebral blood flow and oxygen consumption in man. N A LassenPhysiol Rev195913645234Yes
175616051605.040.6240.6External validity of randomised controlled trials: "to whom do the results of this trial apply?". Peter M RothwellLancet200515639683Yes
175716041604.045.5945.6Ionic dependence of glutamate neurotoxicity. D W ChoiJ Neurosci19872880938Yes
175816041604.049.6549.6Apoptosis in cancer: from pathogenesis to treatment. Rebecca S Y WongJ Exp Clin Cancer Res201121943236No
175916031603.056.8356.8The case-crossover design: a method for studying transient effects on the risk of acute events. M MaclureAm J Epidemiol19911985444Yes
176016031603.036.336.3Thiazolidinediones. Hannele Yki-JärvinenN Engl J Med200415356308No
176148091603.0175.8858.6Multiple imputation using chained equations: Issues and guidance for practice. Ian R White, Patrick Royston, Angela M WoodStat Med201121225900Yes
176216021602.00.00.0Application of a Theory of Enzyme Specificity to Protein Synthesis. D E KoshlandProc Natl Acad Sci U S A195816590179Yes
176316021602.044.944.9Gold-catalyzed organic reactions. A Stephen K HashmiChem Rev200717580975Yes
176416021602.053.1653.2Asthma phenotypes: the evolution from clinical to molecular approaches. Sally E WenzelNat Med201222561835No
176532031601.5112.9456.5Avoiding false positives with PCR. S Kwok, R HiguchiNature19892716852Yes
176632031601.5113.8356.9Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. M M Bradley, P J LangJ Behav Ther Exp Psychiatry19947962581Yes
176748041601.3133.5544.5Cell death: the significance of apoptosis. A H Wyllie, J F Kerr, A R CurrieInt Rev Cytol19807014501No
176816011601.031.6331.6An analysis of vertebrate mRNA sequences: intimations of translational control. M KozakJ Cell Biol19911955461No
176916011601.046.0846.1The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. R R LlinásScience19883059497No
177016011601.033.4833.5The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. A G PearseJ Histochem Cytochem19694143745No
177132021601.066.233.1Signaling to NF-kappaB. Matthew S Hayden, Sankar GhoshGenes Dev200415371334No
177216001600.040.6240.6Molecular biology of prion diseases. S B PrusinerScience19911675487No
177332001600.067.5933.8Inhibitors of mammalian G1 cyclin-dependent kinases. C J Sherr, J M RobertsGenes Dev19957758941No
177432001600.061.8230.9Automated MAD and MIR structure solution. T C Terwilliger, J BerendzenActa Crystallogr D Biol Crystallogr199910089316Yes
177516001600.030.9430.9The microRNA Registry. Sam Griffiths-JonesNucleic Acids Res200414681370Yes
177615991599.036.7836.8A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. D A GewirtzBiochem Pharmacol199910075079No
177715991599.041.8241.8Task switching. Stephen MonsellTrends Cogn Sci200312639695Yes
177815991599.00.00.0Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. O OuchterlonyActa Pathol Microbiol Scand195313079779Yes
177915981598.034.334.3On finding all suboptimal foldings of an RNA molecule. M ZukerScience19892468181No
178031961598.088.6244.3Polyamines. C W Tabor, H TaborAnnu Rev Biochem19846206782No
178115981598.0221.4221.4COVID-19 and mental health: A review of the existing literature. Ravi Philip RajkumarAsian J Psychiatr202032302935Yes
178263901597.5210.952.7Common method biases in behavioral research: a critical review of the literature and recommended remedies. Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P PodsakoffJ Appl Psychol200314516251No
178331931596.566.9533.5The Ki-67 protein: from the known and the unknown. T Scholzen, J GerdesJ Cell Physiol200010653597No
178415961596.028.8328.8Altering the genome by homologous recombination. M R CapecchiScience19892660260No
178515961596.056.9557.0Cytokines in inflammatory bowel disease. Markus F NeurathNat Rev Immunol201424751956No
178647861595.3114.0838.0Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck ØrntoftCancer Res200415289330Yes
178731901595.063.9232.0The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. J O'Keefe, J DostrovskyBrain Res19715124915Yes
178815951595.036.436.4Getting formal with dopamine and reward. Wolfram SchultzNeuron200212383780No
178931901595.0151.3175.7Making sense of Cronbach's alpha. Mohsen Tavakol, Reg DennickInt J Med Educ201128029643No
179031891594.583.2441.6Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. D B Dill, D L CostillJ Appl Physiol19744850854Yes
179115941594.072.6472.6Measurement of health state utilities for economic appraisal. G W TorranceJ Health Econ198610311607No
179215941594.036.736.7Neurovascular regulation in the normal brain and in Alzheimer's disease. Costantino IadecolaNat Rev Neurosci200415100718No
179315931593.070.8870.9The contribution of low birth weight to infant mortality and childhood morbidity. M C McCormickN Engl J Med19853880598No
179415921592.051.8251.8Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). M N MarshGastroenterology19921727768No
179531841592.091.6145.8Oxidative stress, glutamate, and neurodegenerative disorders. J T Coyle, P PuttfarckenScience19937901908No
179615911591.065.8565.8Regulation of noradrenaline release by presynaptic receptor systems. K StarkeRev Physiol Biochem Pharmacol197714389No
179731821591.077.6238.8A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. S Tabor, C C RichardsonProc Natl Acad Sci U S A19853156376Yes
179815911591.052.1552.1Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. W H OldendorfAm J Physiol19715124307Yes
179915911591.038.9238.9The corticosteroid receptor hypothesis of depression. F HolsboerNeuropsychopharmacology200011027914No
180015911591.048.548.5Chlorophyll fluorescence: a probe of photosynthesis in vivo. Neil R BakerAnnu Rev Plant Biol200818444897No
180131821591.0155.7877.9Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. Ivica Letunic, Peer BorkNucleic Acids Res201627095192Yes
180215901590.031.3731.4Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. D I SvergunBiophys J199910354416Yes
180315901590.035.6435.6Hypertrophic cardiomyopathy: a systematic review. Barry J MaronJAMA200211886323No
180415901590.044.2244.2Multiple imputation of discrete and continuous data by fully conditional specification. Stef van BuurenStat Methods Med Res200717621469Yes
180515891589.048.9849.0Efficient analysis of experimental observations. W J DixonAnnu Rev Pharmacol Toxicol19807387124Yes
180631761588.097.348.6Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. D S Bredt, S H SnyderProc Natl Acad Sci U S A19901689048Yes
180715881588.035.635.6The proto-oncogene Bcl-2 and its role in regulating apoptosis. G KroemerNat Med19979176486No
180815881588.054.9555.0The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. E J KhantzianHarv Rev Psychiatry19979385000No
180915871587.036.236.2Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. S C ManolagasEndocr Rev200010782361No
181015861586.056.5556.5Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. P HolzerPharmacol Rev19911852779No
181115861586.043.8543.9Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. P A BradfordClin Microbiol Rev200111585791No
181231711585.5175.1687.6Natural Products as Sources of New Drugs from 1981 to 2014. David J Newman, Gordon M CraggJ Nat Prod201626852623No
181315851585.041.841.8Precision mapping of quantitative trait loci. Z B ZengGenetics19948013918Yes
181415841584.034.3234.3Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. G L SemenzaAnnu Rev Cell Dev Biol199910611972No
181515841584.029.5129.5How cells read TGF-beta signals. J MassaguéNat Rev Mol Cell Biol200011252892No
181615841584.031.331.3Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. R K JainNat Med200111533692No
181715831583.045.1645.2Dithiothreitol, A New Protective Reagent For Sh Groups. W W ClelandBiochemistry196414192894Yes
181815821582.036.636.6The genetical evolution of social behaviour. II. W D HamiltonJ Theor Biol19645875340Yes
181947461582.0115.7138.6Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. Earl S Ford, Wayne H Giles, William H DietzJAMA200211790215Yes
182031631581.5100.3750.2Palladium-catalyzed ligand-directed C-H functionalization reactions. Thomas W Lyons, Melanie S SanfordChem Rev201020078038No
182115811581.037.3937.4The blood-brain barrier: bottleneck in brain drug development. William M PardridgeNeuroRx200515717053No
182231621581.092.846.4Density functionals with broad applicability in chemistry. Yan Zhao, Donald G TruhlarAcc Chem Res200818186612Yes
182315801580.047.4547.5Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. L BravoNutr Rev19989838798No
182431591579.562.4731.2NF-kappaB regulation in the immune system. Qiutang Li, Inder M VermaNat Rev Immunol200212360211No
182515791579.048.5848.6The role of the amygdala in fear and anxiety. M DavisAnnu Rev Neurosci19921575447No
182615781578.052.3752.4Which elements are excited in electrical stimulation of mammalian central nervous system: a review. J B RanckBrain Res19751102064No
182731551577.570.3135.2Lipopolysaccharide endotoxins. Christian R H Raetz, Chris WhitfieldAnnu Rev Biochem200212045108No
182815761576.044.8944.9Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. S HakomoriAnnu Rev Biochem19817023369No
182915761576.042.6642.7The complete general secretory pathway in gram-negative bacteria. A P PugsleyMicrobiol Rev19938096622No
183031521576.068.634.3Neurotrophins: roles in neuronal development and function. E J Huang, L F ReichardtAnnu Rev Neurosci200111520916No
183131511575.588.3144.2Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Sally S Dickerson, Margaret E KemenyPsychol Bull200415122924Yes
183247231574.3128.9543.0Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. M Hasegawa, H Kishino, T YanoJ Mol Evol19853934395Yes
183315741574.052.552.5Biology of interleukin 1. C A DinarelloFASEB J19883277884No
183415741574.034.034.0Mechanisms of bone metastasis. G David RoodmanN Engl J Med200415084698No
183531461573.058.0329.0The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Michael H Glickman, Aaron CiechanoverPhysiol Rev200211917093No
183615731573.036.6636.7Insulin and insulin-like growth factor signalling in neoplasia. Michael PollakNat Rev Cancer200819029956No
183715721572.039.8539.9Aspergillus fumigatus and aspergillosis. J P LatgéClin Microbiol Rev199910194462No
183815721572.046.6546.6A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Ozcan ErelClin Biochem200415003729Yes
183915721572.029.9930.0Immunosuppressive networks in the tumour environment and their therapeutic relevance. Weiping ZouNat Rev Cancer200515776005No
184031431571.565.4232.7Fitting a mixture model by expectation maximization to discover motifs in biopolymers. T L Bailey, C ElkanProc Int Conf Intell Syst Mol Biol19947584402Yes
184131431571.5124.6362.3Alginate: properties and biomedical applications. Kuen Yong Lee, David J MooneyProg Polym Sci201222125349Yes
184215711571.041.5441.5Molecular bases of the acute coronary syndromes. P LibbyCirculation19957758192No
184315711571.037.7837.8HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. J M CoffinScience19957824947Yes
184447121570.7115.1238.4Two-photon laser scanning fluorescence microscopy. W Denk, J H Strickler, W W WebbScience19902321027Yes
184531411570.598.4649.2Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. G R Gibson, M B RoberfroidJ Nutr19957782892No
184615691569.059.9560.0Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. P HolzerNeuroscience19883288903No
184715691569.029.6329.6Intrinsically unstructured proteins. Peter TompaTrends Biochem Sci200212368089No
184831371568.564.5932.3Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. E Krissinel, K HenrickActa Crystallogr D Biol Crystallogr200415572779Yes
184931361568.060.6130.3Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. O Tetsu, F McCormickNature199910201372Yes
185015681568.030.3530.4Regulatory T cells, tumour immunity and immunotherapy. Weiping ZouNat Rev Immunol200616557261No
185131341567.0126.863.4Methods for the thematic synthesis of qualitative research in systematic reviews. James Thomas, Angela HardenBMC Med Res Methodol200818616818Yes
185231321566.061.1630.6The evolutionary fate and consequences of duplicate genes. M Lynch, J S ConeryScience200011073452No
185315661566.00.00.0The estimation of phosphorus. R J AllenBiochem J194016747230Yes
185431301565.068.034.0Microtubules as a target for anticancer drugs. Mary Ann Jordan, Leslie WilsonNat Rev Cancer200415057285No
185515651565.035.8435.8Neurotrophin-regulated signalling pathways. Louis F ReichardtPhilos Trans R Soc Lond B Biol Sci200616939974No
185631271563.596.648.3Oxidative stress and diabetic complications. Ferdinando Giacco, Michael BrownleeCirc Res201021030723No
185715631563.029.7929.8Protein degradation and protection against misfolded or damaged proteins. Alfred L GoldbergNature200314685250No
185831261563.0134.2967.1Parkinson's disease. Lorraine V Kalia, Anthony E LangLancet201525904081No
185915621562.0107.78107.8Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. C S NeerJ Bone Joint Surg Am19725054450Yes
186015621562.00.00.0A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. B C HummelCan J Biochem Physiol195914405350Yes
186131241562.067.1133.6Complex networks orchestrate epithelial-mesenchymal transitions. Jean Paul Thiery, Jonathan P SleemanNat Rev Mol Cell Biol200616493418No
1862171671560.6543.8849.4A new equation to estimate glomerular filtration rate. Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef CoreshAnn Intern Med200919414839Yes
186315601560.033.3233.3From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. W A CatterallNeuron200010798388No
186446791559.7121.0140.3Optimization by simulated annealing. S Kirkpatrick, C D Gelatt, M P VecchiScience198317813860Yes
186515581558.037.1937.2The biology of incretin hormones. Daniel J DruckerCell Metab200616517403No
186615581558.052.4452.4Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. Virginia A MoyerAnn Intern Med201222801674No
186731151557.565.933.0Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. C B Lozzio, B B LozzioBlood1975163658Yes
186831141557.043.7521.9Computed circular dichroism spectra for the evaluation of protein conformation. N Greenfield, G D FasmanBiochemistry19695346390Yes
186946701556.787.2229.1Notch signaling: cell fate control and signal integration in development. S Artavanis-Tsakonas, M D Rand, R J LakeScience199910221902No
187031131556.569.9535.0The human plasma proteome: history, character, and diagnostic prospects. N Leigh Anderson, Norman G AndersonMol Cell Proteomics200212488461No
187193351555.8221.5136.9GROMACS: fast, flexible, and free. David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C BerendsenJ Comput Chem200516211538Yes
187215551555.028.5328.5Selforganization of matter and the evolution of biological macromolecules. M EigenNaturwissenschaften19714942363No
187331101555.0100.9450.5The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. R Doll, R PetoJ Natl Cancer Inst19817017215No
187415551555.031.3731.4The ubiquitin-proteasome proteolytic pathway. A CiechanoverCell19947923371No
187515551555.025.8825.9Neuronal specification in the spinal cord: inductive signals and transcriptional codes. T M JessellNat Rev Genet200011262869No
187615551555.036.6636.7The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. H MaedaAdv Enzyme Regul200111384745No
187731101555.066.5933.3Self-assembly at all scales. George M Whitesides, Bartosz GrzybowskiScience200211923529Yes
187831101555.074.2437.1Unravelling the pathogenesis of inflammatory bowel disease. R J Xavier, D K PodolskyNature200717653185No
187915551555.058.8758.9Modeling Development and Disease with Organoids. Hans CleversCell201627315476No
188015551555.066.1766.2Structure, Function, and Evolution of Coronavirus Spike Proteins. Fang LiAnnu Rev Virol201627578435No
188146631554.392.2530.8Efficient selection for high-expression transfectants with a novel eukaryotic vector. H Niwa, K Yamamura, J MiyazakiGene19911660837Yes
188246631554.3103.8434.6Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. M A Frohman, M K Dush, G R MartinProc Natl Acad Sci U S A19882461560Yes
188315541554.047.4147.4Ordinary magic. Resilience processes in development. A S MastenAm Psychol200111315249Yes
188415531553.077.4577.5Bias in analytic research. D L SackettJ Chronic Dis1979447779Yes
188531061553.066.7533.4Cancer metastasis: building a framework. Gaorav P Gupta, Joan MassaguéCell200617110329No
188631051552.579.6139.8Dali server: conservation mapping in 3D. Liisa Holm, Päivi RosenströmNucleic Acids Res201020457744Yes
188715521552.0103.05103.0The Global Epidemic of the Metabolic Syndrome. Mohammad G SaklayenCurr Hypertens Rep201829480368No
188815511551.032.5132.5Drug discovery: a historical perspective. J DrewsScience200010720314No
188931011550.558.5129.3Mutations affecting segment number and polarity in Drosophila. C Nüsslein-Volhard, E WieschausNature19806776413Yes
189031011550.573.9337.0Malignant gliomas in adults. Patrick Y Wen, Santosh KesariN Engl J Med200818669428No
189146511550.388.629.5A highly sensitive adenylate cyclase assay. Y Salomon, C Londos, M RodbellAnal Biochem19744827395Yes
189230991549.5100.3250.2Neoantigens in cancer immunotherapy. Ton N Schumacher, Robert D SchreiberScience201525838375No
189315491549.033.2533.2Tumor metastasis: mechanistic insights and clinical challenges. Patricia S SteegNat Med200616892035No
189461961549.0153.1938.3Most mammalian mRNAs are conserved targets of microRNAs. Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P BartelGenome Res200918955434Yes
189530981549.0103.1751.6The future of immune checkpoint therapy. Padmanee Sharma, James P AllisonScience201525838373No
189630971548.5113.9557.0A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. J A Horne, O OstbergInt J Chronobiol19761027738Yes
189715481548.038.6138.6Marine viruses--major players in the global ecosystem. Curtis A SuttleNat Rev Microbiol200717853907No
189815471547.042.3642.4Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. A FabiatoAm J Physiol19836346892No
189915471547.047.2247.2Domino Reactions in Organic Synthesis. Lutz F. TietzeChem Rev199611848746Yes
1900154611546.1368.7236.9Multilineage potential of adult human mesenchymal stem cells. M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R MarshakScience199910102814Yes
190146381546.0155.1851.7Phylogenetic identification and in situ detection of individual microbial cells without cultivation. R I Amann, W Ludwig, K H SchleiferMicrobiol Rev19957535888No
190215461546.073.5373.5Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. Kevin A HallgrenTutor Quant Methods Psychol201222833776Yes
190315461546.051.7751.8The role of senescent cells in ageing. Jan M van DeursenNature201424848057No
190430901545.071.9436.0New Giemsa method for the differential staining of sister chromatids. P Perry, S WolffNature19744138930Yes
190515451545.040.9140.9A more meaningful scoring system for determining the severity of coronary heart disease. G G GensiniAm J Cardiol19836823874Yes
190615441544.00.00.0Cerebral vascular accidents in patients over the age of 60. II. Prognosis. J RankinScott Med J195713432835Yes
190730871543.561.9231.0Toll-like receptor control of the adaptive immune responses. Akiko Iwasaki, Ruslan MedzhitovNat Immunol200415454922No
190815431543.030.3930.4E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. J R NevinsScience19921411535Yes
190915421542.056.2656.3Statistical analysis of enzyme kinetic data. W W ClelandMethods Enzymol1979502857Yes
191015421542.077.0977.1Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. F E ZajacCrit Rev Biomed Eng19892676342No
191130841542.074.6237.3Steatohepatitis: a tale of two "hits"? C P Day, O F JamesGastroenterology19989547102No
191215421542.043.6243.6Glycobiology: Toward Understanding the Function of Sugars. Raymond A. DwekChem Rev199611848770Yes
191315421542.061.8361.8α-band oscillations, attention, and controlled access to stored information. Wolfgang KlimeschTrends Cogn Sci201223141428No
191430831541.575.0737.5Cell signaling by receptor tyrosine kinases. Mark A Lemmon, Joseph SchlessingerCell201020602996No
191515411541.036.0536.0Upconversion and anti-Stokes processes with f and d ions in solids. François AuzelChem Rev200414719973Yes
191615391539.052.9753.0Biological applications of ionophores. B C PressmanAnnu Rev Biochem1976786156No
191715391539.034.9334.9Pathogenesis of group A streptococcal infections. M W CunninghamClin Microbiol Rev200010885988No
191815381538.034.0134.0Molecular themes in oncogenesis. J M BishopCell19911988146No
191915381538.043.9744.0Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. A E PeggCancer Res19883123052No
192015381538.046.0146.0Some observations upon a new inhibitor of monoamine oxidase in brain tissue. J P JohnstonBiochem Pharmacol19685659776Yes
192130751537.515.837.9Junctional complexes in various epithelia. M G Farquhar, G E PaladeJ Cell Biol196313944428Yes
192215371537.042.6842.7Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Y Ben-AriNeuroscience19852859548No
192315371537.047.7947.8Evidence for a central component of post-injury pain hypersensitivity. C J WoolfNature19836656869Yes
192430741537.0102.9651.5Thermodynamics of protein association reactions: forces contributing to stability. P D Ross, S SubramanianBiochemistry19817248271Yes
192515371537.042.0542.0n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Philip C CalderAm J Clin Nutr200616841861No
192615361536.045.9245.9Calcium release from the sarcoplasmic reticulum. M EndoPhysiol Rev197713441Yes
192730721536.078.9239.5Empirical threshold values for quantitative trait mapping. G A Churchill, R W DoergeGenetics19947851788Yes
192815361536.048.2348.2The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. G R BuettnerArch Biochem Biophys19938434935No
192915361536.065.5465.5Macrophage Polarization. Peter J MurrayAnnu Rev Physiol201727813830No
193015351535.038.8138.8Early signals in the mitogenic response. E RozengurtScience19863018928No
193115341534.060.8260.8A structured interview guide for the Hamilton Depression Rating Scale. J B WilliamsArch Gen Psychiatry19883395203Yes
193215341534.024.0824.1An enzymic method for the trace iodination of immunoglobulins and other proteins. J J MarchalonisBiochem J19694185494Yes
193315341534.053.553.5Multimodal approach to control postoperative pathophysiology and rehabilitation. H KehletBr J Anaesth19979175983No
193415341534.00.00.0Nutrition needs of mammalian cells in tissue culture. H EagleScience195513255879Yes
193515341534.031.2231.2Antigen-Antibody Crossed Electrophoresis. C B LaurellAnal Biochem196514302464Yes
193615341534.036.9336.9Myeloperoxidase: friend and foe. Seymour J KlebanoffJ Leukoc Biol200515689384No
193730671533.50.00.0A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. G Schmidt, S J ThannhauserJ Biol Chem194521005717Yes
193830641532.061.8330.9The Bcl2 family: regulators of the cellular life-or-death switch. Suzanne Cory, Jerry M AdamsNat Rev Cancer200212209154No
193915321532.043.2843.3Surface plasmon resonance sensors for detection of chemical and biological species. Jirí HomolaChem Rev200818229953No
194030631531.567.5933.8Cell migration: a physically integrated molecular process. D A Lauffenburger, A F HorwitzCell19968608589No
194130621531.0105.452.7Diabetes and cardiovascular disease. The Framingham study. W B Kannel, D L McGeeJAMA1979430798Yes
194215311531.030.7530.8RNA silencing in plants. David BaulcombeNature200415372043No
194315311531.058.0358.0A Protection Motivation Theory of Fear Appeals and Attitude Change1. Ronald W RogersJ Psychol197528136248Yes
194430611530.570.8335.4A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. L Buck, R AxelCell19911840504Yes
194515301530.045.3745.4Recent advances in the biochemistry of polyamines in eukaryotes. A E PeggBiochem J19863087344No
194615301530.030.6730.7The Buccaneer software for automated model building. 1. Tracing protein chains. Kevin CowtanActa Crystallogr D Biol Crystallogr200616929101Yes
194730591529.556.4428.2Cellular motility driven by assembly and disassembly of actin filaments. Thomas D Pollard, Gary G BorisyCell200312600310No
194861171529.2119.8830.0A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. B M Bolstad, R A Irizarry, M Astrand, T P SpeedBioinformatics200312538238Yes
194930581529.062.5931.3Development by self-digestion: molecular mechanisms and biological functions of autophagy. Beth Levine, Daniel J KlionskyDev Cell200415068787No
195015291529.037.937.9Use and misuse of the receiver operating characteristic curve in risk prediction. Nancy R CookCirculation200717309939Yes
195176421528.4152.0430.4Prospective identification of tumorigenic breast cancer cells. Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F ClarkeProc Natl Acad Sci U S A200312629218Yes
195230551527.563.1831.6Coordination of circadian timing in mammals. Steven M Reppert, David R WeaverNature200212198538No
195315261526.034.4734.5Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). K M FoxLancet200313678872Yes
195415261526.036.9236.9Clinical features of metastatic bone disease and risk of skeletal morbidity. Robert E ColemanClin Cancer Res200617062708No
195530511525.5113.5356.8Universal chemical assay for the detection and determination of siderophores. B Schwyn, J B NeilandsAnal Biochem19872952030Yes
195615251525.018.6318.6A soluble protein characteristic of the nervous system. B W MooreBiochem Biophys Res Commun19654953930Yes
195715251525.033.8233.8Ordered porous materials for emerging applications. Mark E DavisNature200212075343No
195815241524.050.6150.6Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. K Anders EricssonAcad Med200415383395No
195915241524.041.2441.2Stress and depression. Constance HammenAnnu Rev Clin Psychol200517716090No
196030471523.571.1535.6Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. F Q Schafer, G R BuettnerFree Radic Biol Med200111368918No
196115231523.041.3141.3Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. L A LiottaCancer Res19862998604No
196260921523.0207.3551.8Guidelines for the process of cross-cultural adaptation of self-report measures. D E Beaton, C Bombardier, F Guillemin, M B FerrazSpine (Phila Pa 1976)200011124735No
196315231523.063.2563.2Nonalcoholic fatty liver disease: a systematic review. Mary E RinellaJAMA201526057287No
196430451522.590.4445.2Extended-connectivity fingerprints. David Rogers, Mathew HahnJ Chem Inf Model201020426451Yes
196515221522.038.0738.1Trophic factors and neuronal survival. Y A BardeNeuron19892697237No
196645631521.096.8932.3The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. S K Hanks, A M Quinn, T HunterScience19883291115No
196715211521.041.9141.9Bioactive microbial metabolites. János BérdyJ Antibiot (Tokyo)200515813176No
196830411520.575.7937.9Obesity. David W Haslam, W Philip T JamesLancet200516198769No
196915201520.037.8637.9Type I diabetes mellitus. A chronic autoimmune disease. G S EisenbarthN Engl J Med19863517648No
197015201520.029.7129.7Macromolecular crowding: obvious but underappreciated. R J EllisTrends Biochem Sci200111590012No
197115201520.028.3228.3Vienna RNA secondary structure server. Ivo L HofackerNucleic Acids Res200312824340Yes
197215201520.034.2634.3The Unified Medical Language System (UMLS): integrating biomedical terminology. Olivier BodenreiderNucleic Acids Res200414681409Yes
197330391519.5180.390.2A scaled version of the General Health Questionnaire. D P Goldberg, V F HillierPsychol Med1979424481Yes
197445581519.396.532.2Adjusting batch effects in microarray expression data using empirical Bayes methods. W Evan Johnson, Cheng Li, Ariel RabinovicBiostatistics200716632515Yes
197515191519.048.0848.1Stability of proteins: small globular proteins. P L PrivalovAdv Protein Chem197944431No
197630371518.594.7147.4How good are my data and what is the resolution? Philip R Evans, Garib N MurshudovActa Crystallogr D Biol Crystallogr201323793146Yes
197730351517.591.1245.6Quality control and preprocessing of metagenomic datasets. Robert Schmieder, Robert EdwardsBioinformatics201121278185Yes
197830281514.066.9933.5NF-kappaB: a key role in inflammatory diseases. P P Tak, G S FiresteinJ Clin Invest200111134171No
197915131513.089.7289.7Stimulated acoustic emissions from within the human auditory system. D T KempJ Acoust Soc Am1978744838Yes
198015131513.045.3545.4Signal transduction by reactive oxygen species. Toren FinkelJ Cell Biol201121746850No
198130261513.0141.4170.7MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Rajesha Rupaimoole, Frank J SlackNat Rev Drug Discov201728209991No
198245381512.798.2832.8Osteoclast differentiation and activation. William J Boyle, W Scott Simonet, David L LaceyNature200312748652No
198315121512.040.0540.0Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. H S PenefskyJ Biol Chem197716006Yes
198415121512.055.8655.9Atherogenesis: a postprandial phenomenon. D B ZilversmitCirculation1979222498Yes
198515111511.034.5234.5Dopamine (3-hydroxytyramine) and brain function. O HornykiewiczPharmacol Rev19665328389No
198615111511.050.550.5A Social Neuroscience Perspective on Adolescent Risk-Taking. Laurence SteinbergDev Rev200818509515Yes
198745321510.7162.4454.1Hydroperoxide metabolism in mammalian organs. B Chance, H Sies, A BoverisPhysiol Rev197937532Yes
198815101510.028.0428.0Aggresomes, inclusion bodies and protein aggregation. R R KopitoTrends Cell Biol200011121744No
198930191509.580.0440.0The gut microbiota shapes intestinal immune responses during health and disease. June L Round, Sarkis K MazmanianNat Rev Immunol200919343057No
199030191509.593.5346.8LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. Roman A Laskowski, Mark B SwindellsJ Chem Inf Model201121919503Yes
199145271509.0101.9334.0Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Hartmuth C. Kolb, M G Finn, K. Barry SharplessAngew Chem Int Ed Engl200111433435Yes
199215091509.033.133.1Far-field optical nanoscopy. Stefan W HellScience200717525330No
199330171508.579.6839.8Materials for electrochemical capacitors. Patrice Simon, Yury GogotsiNat Mater200818956000Yes
199490491508.2260.0943.3A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle CharpentierScience201222745249Yes
199515081508.050.1150.1Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. H J GundersenJ Microsc19863761363Yes
199615081508.046.9747.0The law of attrition. Gunther EysenbachJ Med Internet Res200515829473Yes
199745231507.7115.3638.5Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. B Fischl, M I Sereno, A M DaleNeuroimage19999931269Yes
199815071507.047.8947.9Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. C A BarnesJ Comp Physiol Psychol1979221551Yes
199930141507.057.6228.8Missing pieces in the NF-kappaB puzzle. Sankar Ghosh, Michael KarinCell200211983155No
200030131506.5104.4852.2Van der Waals heterostructures. A K Geim, I V GrigorievaNature201323887427Yes
200130111505.588.7944.4Porosity of 3D biomaterial scaffolds and osteogenesis. Vassilis Karageorgiou, David KaplanBiomaterials200515860204No
200230101505.058.9829.5Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. P J Mitchell, R TjianScience19892667136No
200315051505.033.6833.7The molecular logic of endocannabinoid signalling. Daniele PiomelliNat Rev Neurosci200314595399No
200415021502.032.7132.7The tumor microenvironment and its role in promoting tumor growth. T L WhitesideOncogene200818836471No
200530041502.0107.8553.9The M1 and M2 paradigm of macrophage activation: time for reassessment. Fernando O Martinez, Siamon GordonF1000Prime Rep201424669294No
200615011501.034.1934.2Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J C UnkelessJ Exp Med197990108Yes
200715011501.051.6851.7Lyme disease. A C SteereN Engl J Med19892668764No
200830011500.589.8244.9Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. P J Basser, C PierpaoliJ Magn Reson B19968661285Yes
200930001500.085.9643.0What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. J Zhang, K F YuJAMA19989832001Yes
201015001500.047.8347.8Health consequences of obesity in youth: childhood predictors of adult disease. W H DietzPediatrics199812224658No
201115001500.031.6931.7Cancer epigenomics: DNA methylomes and histone-modification maps. Manel EstellerNat Rev Genet200717339880No
201229991499.50.00.0Lactic dehydrogenase activity in blood. F Wroblewski, J S LadueProc Soc Exp Biol Med195513273400Yes
201314991499.041.8441.8Isolated removal of hypothalamic or other brain nuclei of the rat. M PalkovitsBrain Res19734747772Yes
201414991499.033.0233.0Hyaluronan: from extracellular glue to pericellular cue. Bryan P TooleNat Rev Cancer200415229478No
201514981498.040.2740.3Rheumatoid arthritis. Pathophysiology and implications for therapy. E D HarrisN Engl J Med19902271017No
201614981498.033.7133.7Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. M B LuskinNeuron19938338665Yes
201729961498.078.7739.4Lipid rafts as a membrane-organizing principle. Daniel Lingwood, Kai SimonsScience201020044567No
201814981498.058.8458.8Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement. Virginia A MoyerAnn Intern Med201424378917No
201929951497.586.6443.3Accessories to the crime: functions of cells recruited to the tumor microenvironment. Douglas Hanahan, Lisa M CoussensCancer Cell201222439926No
202044901496.7126.6842.2The fusiform face area: a module in human extrastriate cortex specialized for face perception. N Kanwisher, J McDermott, M M ChunJ Neurosci19979151747Yes
202144901496.7121.3640.5I-TASSER: a unified platform for automated protein structure and function prediction. Ambrish Roy, Alper Kucukural, Yang ZhangNat Protoc201020360767Yes
202229931496.567.6733.8The DNA damage response: making it safe to play with knives. Alberto Ciccia, Stephen J ElledgeMol Cell201020965415No
202314951495.029.8529.9Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. S AvrameasImmunochemistry19694975324Yes
202414941494.033.1633.2Tumor suppressor genes. R A WeinbergScience19911659741No
202514941494.039.0839.1The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. A S FauciScience19883277274No
202614941494.020.1520.1The mechanism of muscular contraction. H E HuxleyScience19694181952No
202789641494.0282.5247.1TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L SalzbergGenome Biol201323618408Yes
202829871493.560.4130.2Chemokines: a new classification system and their role in immunity. A Zlotnik, O YoshieImmunity200010714678No
202914921492.00.00.0The colorimetric determination of phosphorus. E J KingBiochem J193216744823Yes
203029821491.00.00.0Mutations of Bacteria from Virus Sensitivity to Virus Resistance. S E Luria, M DelbrückGenetics194317247100Yes
203114911491.037.0637.1Reconciling the chemistry and biology of reactive oxygen species. Christine C WinterbournNat Chem Biol200818421291No
203244731491.0269.8489.9SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Antoine Daina, Olivier Michielin, Vincent ZoeteSci Rep201728256516Yes
203329801490.099.8249.9How useful is SBF in predicting in vivo bone bioactivity? Tadashi Kokubo, Hiroaki TakadamaBiomaterials200616448693No
203414891489.033.1833.2Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. C TaswellJ Immunol19817009746Yes
203514891489.039.8239.8Redox signaling: nitrosylation and related target interactions of nitric oxide. J S StamlerCell19947923362No
203629781489.065.933.0How matrix metalloproteinases regulate cell behavior. M D Sternlicht, Z WerbAnnu Rev Cell Dev Biol200111687497No
203714891489.05.85.8Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. R W SperryProc Natl Acad Sci U S A196314077501Yes
203814881488.021.6121.6Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. J W OlneyScience19695778021Yes
203914871487.026.0126.0Histone acetylation and transcriptional regulatory mechanisms. K StruhlGenes Dev19989499396No
204014871487.036.9537.0An economic method for the fluorescent labeling of PCR fragments. M SchuelkeNat Biotechnol200010657137Yes
204114861486.041.1941.2Emotion regulation: affective, cognitive, and social consequences. James J GrossPsychophysiology200212212647No
204229711485.5174.9987.5Rating systems in the evaluation of knee ligament injuries. Y Tegner, J LysholmClin Orthop Relat Res19854028566Yes
204314841484.045.9546.0Superoxide dismutases. I FridovichAnnu Rev Biochem19751094908No
204414841484.040.6940.7Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. J A BeavoPhysiol Rev19957480160No
204514831483.032.0232.0Critical period plasticity in local cortical circuits. Takao K HenschNat Rev Neurosci200516261181No
204644481482.7108.9936.3Membrane lipids: where they are and how they behave. Gerrit van Meer, Dennis R Voelker, Gerald W FeigensonNat Rev Mol Cell Biol200818216768No
204729651482.564.0932.0Escaping free-energy minima. Alessandro Laio, Michele ParrinelloProc Natl Acad Sci U S A200212271136Yes
2048192681482.2501.6938.6Clustal W and Clustal X version 2.0. M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G HigginsBioinformatics200717846036Yes
204914821482.042.9442.9Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. M D MainesFASEB J19883290025No
205014821482.034.8534.9Oxidative stress in Parkinson's disease. Peter JennerAnn Neurol200312666096No
205114821482.048.3648.4The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. Poul Erik PetersenCommunity Dent Oral Epidemiol200315015736Yes
205229631481.582.4141.2Genome regulation by long noncoding RNAs. John L Rinn, Howard Y ChangAnnu Rev Biochem201222663078No
205314811481.030.0430.0Ionic blockage of sodium channels in nerve. A M WoodhullJ Gen Physiol19734541078Yes
205414811481.029.8729.9Defective repair replication of DNA in xeroderma pigmentosum. J E CleaverNature19685655953Yes
205514811481.033.6533.6Simple methods for "staining with lead" at high pH in electron microscopy. M J KarnovskyJ Biophys Biochem Cytol196114454024Yes
205644411480.379.0526.3Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. C A Winter, E A Risley, G W NussProc Soc Exp Biol Med196214001233Yes
205714801480.049.7149.7The measurement of psychological androgyny. S L BemJ Consult Clin Psychol19744823550Yes
205814801480.046.1446.1Polycystic ovary syndrome. S FranksN Engl J Med19957651477No
205929601480.076.7438.4The expanding universe of T-cell subsets: Th1, Th2 and more. T R Mosmann, S SadImmunol Today19968820272No
206014801480.047.7847.8SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. B P O'ConnorBehav Res Methods Instrum Comput200011029811Yes
2061103591479.9221.1331.6Embryonic stem cell lines derived from human blastocysts. J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M JonesScience19989804556Yes
206214791479.035.1535.1Neuronal synchrony: a versatile code for the definition of relations? W SingerNeuron199910677026No
206314791479.039.8239.8A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. J EngelEpilepsia200111422340Yes
206414791479.032.5632.6The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. S E KahnDiabetologia200312637977No
206529581479.064.4232.2Cellular senescence: when bad things happen to good cells. Judith Campisi, Fabrizio d'Adda di FagagnaNat Rev Mol Cell Biol200717667954No
206614791479.058.0758.1MorphoJ: an integrated software package for geometric morphometrics. Christian Peter KlingenbergMol Ecol Resour201121429143Yes
206788731478.8208.8834.8Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O LötvallNat Cell Biol200717486113Yes
206859131478.2244.1661.0A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. M A Markwell, S M Haas, L L Bieber, N E TolbertAnal Biochem197898070Yes
206914781478.033.8633.9The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. M TakeichiDevelopment19883048970No
207044331477.733.0611.0The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. J T Dodge, C Mitchell, D J HanahanArch Biochem Biophys196314028302Yes
207114771477.070.8270.8Chronic illness as biographical disruption. M BurySociol Health Illn198210260456Yes
207214771477.037.3637.4Interoception: the sense of the physiological condition of the body. A D CraigCurr Opin Neurobiol200312965300No
207388471474.5261.3843.6Cancer statistics, 2009. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J ThunCA Cancer J Clin200919474385Yes
207414741474.026.126.1R factor transfer in Rhizobium leguminosarum. J E BeringerJ Gen Microbiol19744612098Yes
207514741474.048.0248.0Inflammation in atherosclerosis. Peter LibbyArterioscler Thromb Vasc Biol201222895665No
207614731473.042.8642.9Mitochondria and cancer. Douglas C WallaceNat Rev Cancer201223001348No
207744181472.7114.1738.1How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. R M Sapolsky, L M Romero, A U MunckEndocr Rev200010696570No
207829431471.577.5238.8A general method for isolation of high molecular weight DNA from eukaryotes. N Blin, D W StaffordNucleic Acids Res1976987581Yes
207914701470.064.9164.9Human agency in social cognitive theory. A BanduraAm Psychol19892782727Yes
208014701470.038.4738.5Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Michael F HolickAm J Clin Nutr200415585788No
208129401470.076.3538.2Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. Gerard Talavera, Jose CastresanaSyst Biol200717654362Yes
208214691469.064.1964.2Derivation and validation of a short-form oral health impact profile. G D SladeCommunity Dent Oral Epidemiol19979332805Yes
208314681468.07.747.7Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. H E HuxleyJ Mol Biol196314064165Yes
208414681468.031.6731.7Autophagy: from phenomenology to molecular understanding in less than a decade. Daniel J KlionskyNat Rev Mol Cell Biol200717712358No
208544021467.3153.1651.1CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Teresa C Horan, Mary Andrus, Margaret A DudeckAm J Infect Control200818538699No
2086132051467.2406.045.1The 1982 revised criteria for the classification of systemic lupus erythematosus. E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J WinchesterArthritis Rheum19827138600Yes
208744001466.792.9531.0TOR signaling in growth and metabolism. Stephan Wullschleger, Robbie Loewith, Michael N HallCell200616469695No
208829321466.0115.2657.6Assessment of eating disorders: interview or self-report questionnaire? C G Fairburn, S J BeglinInt J Eat Disord19947866415Yes
208914661466.033.9934.0PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. B M SpiegelmanDiabetes19989568680No
209014661466.00.00.0Modality and topographic properties of single neurons of cat's somatic sensory cortex. V B MountcastleJ Neurophysiol195713439410Yes
209129321466.074.8437.4Abdominal obesity and metabolic syndrome. Jean-Pierre Després, Isabelle LemieuxNature200617167477No
209214651465.045.245.2Equipoise and the ethics of clinical research. B FreedmanN Engl J Med19873600702Yes
209314651465.045.5845.6The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. J L CummingsNeurology19979153155No
209414651465.00.00.0The free amino groups of insulin. F SangerBiochem J194516747948Yes
209514641464.031.131.1Topoisomerase I inhibitors: camptothecins and beyond. Yves PommierNat Rev Cancer200616990856No
209614631463.036.1936.2Microbial ecology of the gastrointestinal tract. D C SavageAnnu Rev Microbiol1977334036No
209714631463.035.935.9Fast and robust fixed-point algorithms for independent component analysis. A HyvärinenIEEE Trans Neural Netw199918252563Yes
209829241462.086.3743.2From best evidence to best practice: effective implementation of change in patients' care. Richard Grol, Jeremy GrimshawLancet200314568747No
209914621462.00.00.0Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. I E BushBiochem J195214915960Yes
210058441461.0128.0332.0Probability-based protein identification by searching sequence databases using mass spectrometry data. D N Perkins, D J Pappin, D M Creasy, J S CottrellElectrophoresis199910612281Yes
210114601460.034.4634.5Binary Agrobacterium vectors for plant transformation. M BevanNucleic Acids Res19846095209Yes
210214601460.040.0440.0Leishmaniasis: current situation and new perspectives. P DesjeuxComp Immunol Microbiol Infect Dis200415225981No
210314591459.028.9428.9The organization of proteins in the human red blood cell membrane. A review. T L SteckJ Cell Biol19744600883No
210414591459.00.00.0The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. O V BatsonAnn Surg194017857618Yes
210529171458.599.5449.8Assay of proteins in the presence of interfering materials. A Bensadoun, D WeinsteinAnal Biochem19761259145Yes
210629151457.50.00.0Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. D H Clarke, J CasalsAm J Trop Med Hyg195813571577Yes
210729131456.585.7342.9The cortical organization of speech processing. Gregory Hickok, David PoeppelNat Rev Neurosci200717431404No
210814561456.027.3327.3The Relation Of Recombination To Mutational Advance. H J MullerMutat Res196414195748Yes
210914551455.00.00.0Potential, Impedance, And Rectification In Membranes. D E GoldmanJ Gen Physiol194319873371Yes
211029101455.091.1345.6Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Riccardo Lencioni, Josep M LlovetSemin Liver Dis201020175033No
211129081454.066.5133.3Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. C Auffray, F RougeonEur J Biochem19806772444Yes
211214541454.054.0154.0Cardiac valve surgery--the "French correction". A CarpentierJ Thorac Cardiovasc Surg19836887954Yes
211314541454.00.00.0A modified ninhydrin colorimetric analysis for amino acids. H RosenArch Biochem Biophys195713412116Yes
211414541454.036.436.4Wound healing and its impairment in the diabetic foot. Vincent FalangaLancet200516291068No
211529071453.558.029.0Intrinsically unstructured proteins and their functions. H Jane Dyson, Peter E WrightNat Rev Mol Cell Biol200515738986No
211614531453.033.5633.6Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. P C NowellCancer Res196014427849Yes
211743571452.394.9331.6Telomeres shorten during ageing of human fibroblasts. C B Harley, A B Futcher, C W GreiderNature19902342578Yes
211814521452.035.5335.5General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. R A HoughtenProc Natl Acad Sci U S A19852410914Yes
211914521452.048.4848.5Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. G A McPhersonJ Pharmacol Methods19853840547Yes
212014521452.019.6219.6Codon--anticodon pairing: the wobble hypothesis. F H CrickJ Mol Biol19665969078Yes
212114521452.031.6731.7Protein misfolding, evolution and disease. C M DobsonTrends Biochem Sci199910470028No
212229031451.577.5638.8Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. B R Celli, W MacNeeEur Respir J200415219010No
212329021451.094.2447.1Peptidoglycan types of bacterial cell walls and their taxonomic implications. K H Schleifer, O KandlerBacteriol Rev19724568761No
212414511451.046.2846.3A clinical method for assessing the ventilatory response to carbon dioxide. D J ReadAustralas Ann Med19676032026Yes
212514511451.072.5772.6Neutrophil extracellular traps in immunity and disease. Venizelos PapayannopoulosNat Rev Immunol201828990587No
212629011450.574.4837.2Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. I Issemann, S GreenNature19902129546Yes
212758011450.2180.6645.2The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. L A Sternberger, P H Hardy, J J Cuculis, H G MeyerJ Histochem Cytochem19704192899Yes
212829001450.090.8345.4Functional architecture of basal ganglia circuits: neural substrates of parallel processing. G E Alexander, M D CrutcherTrends Neurosci19901695401No
212914501450.042.0842.1Human cardiovascular adjustments to exercise and thermal stress. L B RowellPhysiol Rev19744587247No
213029001450.079.3439.7A rapid boiling method for the preparation of bacterial plasmids. D S Holmes, M QuigleyAnal Biochem19816269464Yes
213114501450.036.2236.2Stress and hippocampal plasticity. B S McEwenAnnu Rev Neurosci199910202533No
213214501450.030.4930.5Neurotrophins as synaptic modulators. M M PooNat Rev Neurosci200111253356No
213314501450.00.00.0Starch gel electrophoresis in a discontinous system of buffers. M D PoulikNature195713493570Yes
213428991449.572.2136.13' non-coding region sequences in eukaryotic messenger RNA. N J Proudfoot, G G BrownleeNature1976822353Yes
213528991449.567.1533.6The MAPK signaling cascade. R Seger, E G KrebsFASEB J19957601337No
213643481449.3132.1544.1Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. S van der Linden, H A Valkenburg, A CatsArthritis Rheum19846231933Yes
213714491449.035.635.6The amygdala modulates the consolidation of memories of emotionally arousing experiences. James L McGaughAnnu Rev Neurosci200415217324No
213814491449.043.9443.9The functional gastrointestinal disorders and the Rome III process. Douglas A DrossmanGastroenterology200616678553No
213914491449.032.8332.8Cell signaling. H2O2, a necessary evil for cell signaling. Sue Goo RheeScience200616809515Yes
214014491449.031.7231.7Mitochondria: dynamic organelles in disease, aging, and development. David C ChanCell200616814712No
214143451448.3109.3136.4The metabolic syndrome. Robert H Eckel, Scott M Grundy, Paul Z ZimmetLancet200515836891No
214243431447.792.6830.9NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. S Ghosh, M J May, E B KoppAnnu Rev Immunol19989597130No
214328951447.560.2430.1Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Joshua E Elias, Steven P GygiNat Methods200717327847Yes
214414471447.033.5633.6Developmental cell death: morphological diversity and multiple mechanisms. P G ClarkeAnat Embryol (Berl)19902186664No
214528931446.584.642.3Mediation in experimental and nonexperimental studies: new procedures and recommendations. Patrick E Shrout, Niall BolgerPsychol Methods200212530702Yes
214628931446.5113.0856.5Elements of cancer immunity and the cancer-immune set point. Daniel S Chen, Ira MellmanNature201728102259No
214714461446.040.6940.7Treatment of infections associated with surgical implants. Rabih O DarouicheN Engl J Med200415070792No
214828891444.50.00.0Mutants of Escherichia coli requiring methionine or vitamin B12. B D Davis, E S MingioliJ Bacteriol195015436457Yes
214914441444.049.4849.5Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. S KatzJ Am Geriatr Soc19836418786No
215014441444.040.9440.9The Hospital Anxiety And Depression Scale. R Philip SnaithHealth Qual Life Outcomes200312914662Yes
215128851442.561.6530.8A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. A H Anton, D F SayreJ Pharmacol Exp Ther196214013351Yes
215214421442.037.3837.4Capacitative calcium entry revisited. J W PutneyCell Calcium19901965707No
215328841442.085.943.0The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. J D Hayes, D J PulfordCrit Rev Biochem Mol Biol19958770536No
215443251441.735.4611.8Improved method for the determination of blood glutathione. E Beutler, O Duron, B M KellyJ Lab Clin Med196313967893Yes
215514411441.057.0457.0An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. J Kabat-ZinnGen Hosp Psychiatry19827042457Yes
215628811440.5109.4254.7A new initiative on precision medicine. Francis S Collins, Harold VarmusN Engl J Med201525635347Yes
215714401440.037.9938.0Cell and environment interactions in tumor microregions: the multicell spheroid model. R M SutherlandScience19882451290Yes
215828801440.094.5347.3The efficiency of systematic sampling in stereology and its prediction. H J Gundersen, E B JensenJ Microsc19873430576Yes
215914401440.034.7434.7Origin, biogenesis, and activity of plant microRNAs. Olivier VoinnetCell200919239888No
216014391439.071.771.7International classification of sleep disorders-third edition: highlights and modifications. Michael J SateiaChest201425367475No
216128761438.078.1139.1Angiogenesis. J Folkman, Y ShingJ Biol Chem19921375931No
216214381438.059.3259.3Working memory: theories, models, and controversies. Alan BaddeleyAnnu Rev Psychol201221961947No
216314371437.050.2550.2Phase retrieval algorithms: a comparison. J R FienupAppl Opt198220396114Yes
216428711435.560.1630.1The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. M S Brown, J L GoldsteinCell19979150132No
216514351435.037.5337.5The world health report 2002 - reducing risks, promoting healthy life. J J GuilbertEduc Health (Abingdon)200314741909Yes
2166129081434.2630.9470.1Cancer statistics in China, 2015. Wanqing Chen, Rongshou Zheng, Peter D Baade, Siwei Zhang, Hongmei Zeng, Freddie Bray, Ahmedin Jemal, Xue Qin Yu, Jie HeCA Cancer J Clin201626808342Yes
216714341434.056.2156.2Reliability and factor analysis of the Epworth Sleepiness Scale. M W JohnsSleep19921519015Yes
216814341434.074.0474.0The determinants of parenting: a process model. J BelskyChild Dev19846705636Yes
216928681434.00.00.0Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. H J Bloom, W W RichardsonBr J Cancer195713499785Yes
217014341434.034.1834.2The use of nanocrystals in biological detection. Paul AlivisatosNat Biotechnol200414704706Yes
217114341434.042.1242.1Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. M Robin DiMatteoMed Care200415076819Yes
217214341434.031.4931.5DNA damage, aging, and cancer. Jan H J HoeijmakersN Engl J Med200919812404No
217328631431.567.533.8Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. H Cai, D G HarrisonCirc Res200011073878No
217414311431.029.2529.2Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. S S FergusonPharmacol Rev200111171937No
217542921430.7100.7433.6Long non-coding RNAs: insights into functions. Tim R Mercer, Marcel E Dinger, John S MattickNat Rev Genet200919188922No
217628591429.50.00.0Brain stem reticular formation and activation of the EEG. G Moruzzi, H W MagounElectroencephalogr Clin Neurophysiol194918421835Yes
2177100061429.4280.740.1BLAST+: architecture and applications. Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L MaddenBMC Bioinformatics200920003500Yes
217814291429.040.1840.2Graphene transistors. Frank SchwierzNat Nanotechnol201020512128Yes
217928571428.591.3645.7Synchronization of Plasmodium falciparum erythrocytic stages in culture. C Lambros, J P VanderbergJ Parasitol1979383936Yes
218028571428.573.1736.6Molecular replacement with MOLREP. Alexei Vagin, Alexei TeplyakovActa Crystallogr D Biol Crystallogr201020057045Yes
2181128531428.1394.9243.9The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C DunbarJ Clin Psychiatry19989881538No
218228561428.054.1427.1T-cell antigen receptor genes and T-cell recognition. M M Davis, P J BjorkmanNature19883043226No
218314281428.043.6543.6Biological basis of the behavior of sick animals. B L HartNeurosci Biobehav Rev19883050629No
218414281428.049.5649.6The prevalence of 'alexithymic' characteristics in psychosomatic patients. P E SifneosPsychother Psychosom19734770536Yes
218514281428.091.8491.8The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. F DenisSpine (Phila Pa 1976)19836670016Yes
218671371427.4153.2830.7Site-directed mutagenesis by overlap extension using the polymerase chain reaction. S N Ho, H D Hunt, R M Horton, J K Pullen, L R PeaseGene19892744487Yes
2187114171427.1284.3435.5Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M JoliotNeuroimage200211771995Yes
218814271427.042.0742.1Strong localization of photons in certain disordered dielectric superlattices. S JohnPhys Rev Lett198710034761Yes
218942811427.088.1429.4Toll-like receptors. Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo AkiraAnnu Rev Immunol200312524386No
219014271427.040.6640.7Recent developments in isocyanide based multicomponent reactions in applied chemistry. Alexander DömlingChem Rev200616402771No
219128521426.069.7534.9Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. E S Lander, D BotsteinGenetics19892563713Yes
219214261426.047.6747.7Gene flow and the geographic structure of natural populations. M SlatkinScience19873576198Yes
219314261426.049.6249.6Colorimetric determination of phospholipids with ammonium ferrothiocyanate. J C StewartAnal Biochem19806892980Yes
219414261426.041.1341.1The aging process. D HarmanProc Natl Acad Sci U S A19816947277Yes
219514261426.033.333.3Functions of ceramide in coordinating cellular responses to stress. Y A HannunScience19968943189No
219614261426.037.8737.9Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. J WymanAdv Protein Chem196414268785No
219728521426.0120.4460.23D bioprinting of tissues and organs. Sean V Murphy, Anthony AtalaNat Biotechnol201425093879Yes
219814251425.041.9441.9Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. E N BergmanPhysiol Rev19902181501No
219914251425.026.7526.8Ubiquitin-dependent protein degradation. M HochstrasserAnnu Rev Genet19968982460No
220028491424.596.7748.4Selective loss of central cholinergic neurons in Alzheimer's disease. P Davies, A J MaloneyLancet197663862Yes
220128491424.540.4120.2The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. E G Gray, V P WhittakerJ Anat196213901297Yes
220214241424.00.00.0A new readability yardstick. R FleschJ Appl Psychol194818867058Yes
220314231423.051.7551.8Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. M P BlausteinAm J Physiol1977324293No
220414231423.035.2735.3The 'effective number of codons' used in a gene. F WrightGene19902110097Yes
2205156531423.0413.8837.6The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristoGenome Res201020644199Yes
220642681422.783.7627.9The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Fabio Martinon, Kimberly Burns, Jürg TschoppMol Cell200212191486Yes
220714221422.025.7925.8The DNA methyltransferases of mammals. T H BestorHum Mol Genet200011005794No
220828421421.084.4842.2Intracellular pH. A Roos, W F BoronPhysiol Rev19817012859No
220956841421.0263.6265.9Prevalence of childhood and adult obesity in the United States, 2011-2012. Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M FlegalJAMA201424570244Yes
221028411420.555.0327.5Autophagy as a regulated pathway of cellular degradation. D J Klionsky, S D EmrScience200011099404No
221128401420.0144.5572.3A simple practice guide for dose conversion between animals and human. Anroop B Nair, Shery JacobJ Basic Clin Pharm201627057123No
221228391419.555.0727.5Cancer genes and the pathways they control. Bert Vogelstein, Kenneth W KinzlerNat Med200415286780No
221314191419.042.9843.0Mate selection-a selection for a handicap. A ZahaviJ Theor Biol19751195756Yes
221414191419.093.2593.2The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. F C EwaldClin Orthop Relat Res19892805502Yes
221514191419.042.5142.5The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Artemis P SimopoulosExp Biol Med (Maywood)200818408140No
221656751418.8165.6341.4Reversible middle cerebral artery occlusion without craniectomy in rats. E Z Longa, P R Weinstein, S Carlson, R CumminsStroke19892643202Yes
221714181418.041.4941.5The fetal and infant origins of adult disease. D J BarkerBMJ19902252919No
221842541418.0141.1547.1Vascular endothelial cells synthesize nitric oxide from L-arginine. R M Palmer, D S Ashton, S MoncadaNature19883131684Yes
221914171417.056.7456.7Social phobia. M R LiebowitzMod Probl Pharmacopsychiatry19872885745Yes
222014171417.035.4135.4Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. S S LehrerBiochemistry19715119250Yes
222114171417.033.5233.5Proinflammatory cytokines. C A DinarelloChest200010936147No
222214171417.044.7844.8Formation of glasses from liquids and biopolymers. C A AngellScience199517770101Yes
222314171417.0115.81115.8User's guide to correlation coefficients. Haldun AkogluTurk J Emerg Med201830191186No
222456651416.2144.5236.1Microbial ecology: human gut microbes associated with obesity. Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I GordonNature200617183309Yes
222514161416.035.9836.0Hemispheric asymmetry reduction in older adults: the HAROLD model. Roberto CabezaPsychol Aging200211931290No
222628321416.00.00.0Virus interference. I. The interferon. A Isaacs, J LindenmannProc R Soc Lond B Biol Sci195713465720Yes
222714161416.032.2132.2Nonaqueous liquid electrolytes for lithium-based rechargeable batteries. Kang XuChem Rev200415669157Yes
222814161416.052.5752.6Diversity in tropical rain forests and coral reefs. J H ConnellScience197817840770Yes
222928281414.079.2939.6Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. F D Lublin, S C ReingoldNeurology19968780061Yes
223014141414.026.3526.4NK cell receptors. L L LanierAnnu Rev Immunol19989597134No
223128281414.071.9436.0Morris water maze: procedures for assessing spatial and related forms of learning and memory. Charles V Vorhees, Michael T WilliamsNat Protoc200617406317Yes
223214131413.022.9222.9Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. K S McCullyAm J Pathol19695792556Yes
223328261413.096.9548.5The framing of decisions and the psychology of choice. A Tversky, D KahnemanScience19817455683Yes
223414131413.040.9541.0Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Charles A DinarelloBlood201121304099No
223514111411.059.5459.5The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. E J KhantzianAm J Psychiatry19853904487No
223614111411.039.7439.7Isolation and cultivation of Lyme disease spirochetes. A G BarbourYale J Biol Med19846393604Yes
223728221411.071.6135.8A globally coherent fingerprint of climate change impacts across natural systems. Camille Parmesan, Gary YoheNature200312511946Yes
223828211410.50.00.0The effect of sodium ions on the electrical activity of giant axon of the squid. A L Hodgkin, B KatzJ Physiol194918128147Yes
223928201410.080.7940.4Empirical predictions of protein conformation. P Y Chou, G D FasmanAnnu Rev Biochem1978354496No
224014101410.033.5833.6The basic science of gene therapy. R C MulliganScience19938493530No
224114091409.026.9126.9The significance of responses of the genome to challenge. B McClintockScience198415739260No
224228171408.556.2528.1Short-term synaptic plasticity. Robert S Zucker, Wade G RegehrAnnu Rev Physiol200211826273No
224314081408.032.8732.9Speculations on the functions of the major heat shock and glucose-regulated proteins. H R PelhamCell19862944601Yes
224428161408.0107.553.8Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. Susan Whitfield-Gabrieli, Alfonso Nieto-CastanonBrain Connect201222642651Yes
224528141407.054.927.4Wnt signalling in stem cells and cancer. Tannishtha Reya, Hans CleversNature200515829953No
224628131406.577.2838.6Transforming growth factor beta in tissue fibrosis. W A Border, N A NobleN Engl J Med19947935686No
224714061406.035.3235.3Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. Y ShaiBiochim Biophys Acta199910590302No
224814061406.037.4837.5A note on robust variance estimation for cluster-correlated data. R L WilliamsBiometrics200010877330Yes
224928121406.052.3626.2Oncogenic kinase signalling. P Blume-Jensen, T HunterNature200111357143No
225028101405.069.7134.9Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. M D Pierschbacher, E RuoslahtiNature19846325925Yes
225114051405.062.3462.3A New Weighting System For Mean Surface Temperature Of The Human Body. N L RamanathanJ Appl Physiol196414173555Yes
225242121404.0111.6137.2Fast model-based estimation of ancestry in unrelated individuals. David H Alexander, John Novembre, Kenneth LangeGenome Res200919648217Yes
225314041404.048.0248.0Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. Russell LandeEvolution197928568194Yes
225442111403.7121.1140.4Dose translation from animal to human studies revisited. Shannon Reagan-Shaw, Minakshi Nihal, Nihal AhmadFASEB J200817942826Yes
225514031403.045.8845.9Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. N KriegerAm J Public Health19921566949Yes
225628061403.087.7743.9Performing the exact test of Hardy-Weinberg proportion for multiple alleles. S W Guo, E A ThompsonBiometrics19921637966Yes
225714031403.035.6735.7The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. T SzkudelskiPhysiol Res200111829314No
225814031403.038.9639.0The debate over dopamine's role in reward: the case for incentive salience. Kent C BerridgePsychopharmacology (Berl)200717072591No
225928051402.571.1935.6CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. D G Higgins, P M SharpGene19883243435Yes
226028051402.572.5736.3Alternative activation of macrophages: mechanism and functions. Siamon Gordon, Fernando O MartinezImmunity201020510870No
226114021402.025.1125.1Selection of successive tumour lines for metastasis. I J FidlerNat New Biol19734512654Yes
226242061402.0146.048.7Structure-antioxidant activity relationships of flavonoids and phenolic acids. C A Rice-Evans, N J Miller, G PagangaFree Radic Biol Med19968743980Yes
226328031401.542.1521.1Prediction of protein conformation. P Y Chou, G D FasmanBiochemistry19744358940Yes
226428031401.562.4931.2Raster3D Version 2.0. A program for photorealistic molecular graphics. E A Merritt, M E MurphyActa Crystallogr D Biol Crystallogr199415299354Yes
226514011401.032.0632.1Protein kinase C: structure, function, and regulation. A C NewtonJ Biol Chem19957499357No
226614011401.036.6236.6The epidemiology of venous thromboembolism. Richard H WhiteCirculation200312814979No
226728001400.061.6730.8An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. A A Beg, D BaltimoreScience19968864118Yes
226827981399.069.8234.9Molecular beacons: probes that fluoresce upon hybridization. S Tyagi, F R KramerNat Biotechnol19969630890Yes
2269167871398.9706.1658.8Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Sue Richards, Nazneen Aziz, Sherri Bale, David Bick, Soma Das, Julie Gastier-Foster, Wayne W Grody, Madhuri Hegde, Elaine Lyon, Elaine Spector, Karl Voelkerding, Heidi L RehmGenet Med201525741868No
227013981398.028.8828.9The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. R C LewontinGenetics196417248194Yes
227141921397.3218.0772.7Radiomics: Images Are More than Pictures, They Are Data. Robert J Gillies, Paul E Kinahan, Hedvig HricakRadiology201626579733Yes
227213971397.036.0536.0The intraclass correlation coefficient as a measure of reliability. J J BartkoPsychol Rep19665942109Yes
227313971397.062.3962.4Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. P de LevaJ Biomech19968872282Yes
227441911397.085.1428.4Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Michael J Rust, Mark Bates, Xiaowei ZhuangNat Methods200616896339Yes
227527941397.067.1433.6Decision curve analysis: a novel method for evaluating prediction models. Andrew J Vickers, Elena B ElkinMed Decis Making200617099194Yes
227613971397.040.5640.6Breakthrough of the year 2013. Cancer immunotherapy. Jennifer Couzin-FrankelScience201324357284No
227727911395.573.0136.5Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. E Engvall, P PerlmannImmunochemistry19715135623Yes
227827911395.589.0944.5Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. Johan W S Vlaeyen, Steven J LintonPain200010781906No
227927911395.561.8430.9The pathophysiology and treatment of sepsis. Richard S Hotchkiss, Irene E KarlN Engl J Med200312519925No
228013951395.050.1850.2The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. A RaineSchizophr Bull19911805349Yes
228113951395.050.1850.2Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. T Florian JaegerJ Mem Lang200819884961Yes
228213951395.066.2666.3PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors. Anthony L SpekActa Crystallogr C Struct Chem201525567569Yes
228327881394.082.5341.3Glycine potentiates the NMDA response in cultured mouse brain neurons. J W Johnson, P AscherNature19872433595Yes
228413941394.052.8852.9Presidential address, 1980. Surprise!...Surprise? E DonchinPsychophysiology19817280146Yes
228513941394.060.560.5Periodontitis: from microbial immune subversion to systemic inflammation. George HajishengallisNat Rev Immunol201525534621No
228683621393.7214.7935.8Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur WheelerN Engl J Med200010793162Yes
228727871393.5149.5274.8Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. L F Berkman, S L SymeAm J Epidemiol1979425958Yes
228813931393.033.433.4Drug-induced prolongation of the QT interval. Dan M RodenN Engl J Med200414999113No
228927851392.562.531.2Immunoassay of endogenous plasma insulin in man. R S Yalow, S A BersonJ Clin Invest196013846364Yes
229027851392.5120.8760.4Sex differences in immune responses. Sabra L Klein, Katie L FlanaganNat Rev Immunol201627546235No
229113921392.032.6832.7Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Bei-Fan ZhouBiomed Environ Sci200212046553Yes
229227831391.582.2941.1Microdetermination of long-chain fatty acids in plasma and tissues. V P Dole, H MeinertzJ Biol Chem196013817286Yes
229313911391.030.4630.5The ATP synthase--a splendid molecular machine. P D BoyerAnnu Rev Biochem19979242922No
229413911391.024.1724.2The economics of ribosome biosynthesis in yeast. J R WarnerTrends Biochem Sci199910542411No
229513911391.027.0827.1Natively unfolded proteins: a point where biology waits for physics. Vladimir N UverskyProtein Sci200211910019No
229655641391.0154.4538.6Image quality assessment: from error visibility to structural similarity. Zhou Wang, Alan Conrad Bovik, Hamid Rahim Sheikh, Eero P SimoncelliIEEE Trans Image Process200415376593Yes
229713901390.050.0950.1Quantitative methods in the review of epidemiologic literature. S GreenlandEpidemiol Rev19873678409Yes
229827801390.085.9943.0Unidentified curved bacilli on gastric epithelium in active chronic gastritis. J R Warren, B MarshallLancet19836134060Yes
229913901390.062.8862.9Mechanisms linking social ties and support to physical and mental health. Peggy A ThoitsJ Health Soc Behav201121673143No
230013891389.023.3423.3Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. K FuxeActa Physiol Scand Suppl196514319769Yes
230127781389.065.7132.9Inflammation, stress, and diabetes. Kathryn E Wellen, Gökhan S HotamisligilJ Clin Invest200515864338No
230227771388.580.4440.2CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. Mattias Jakobsson, Noah A RosenbergBioinformatics200717485429Yes
230313881388.029.629.6Cancer of the ovary. Stephen A CannistraN Engl J Med200415590954No
230427751387.563.531.8A method of trace iodination of proteins for immunologic studies. P J McConahey, F J DixonInt Arch Allergy Appl Immunol19664160044Yes
230527751387.567.4133.7Powering the planet: chemical challenges in solar energy utilization. Nathan S Lewis, Daniel G NoceraProc Natl Acad Sci U S A200617043226Yes
230641621387.3100.3633.5Wnt/beta-catenin signaling: components, mechanisms, and diseases. Bryan T MacDonald, Keiko Tamai, Xi HeDev Cell200919619488No
230727741387.0436.8218.4Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation. Ivica Letunic, Peer BorkNucleic Acids Res202133885785Yes
230827721386.071.4535.7A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. J Messing, J VieiraGene19826295880Yes
230913861386.033.7733.8Tobacco smoke carcinogens and lung cancer. S S HechtJ Natl Cancer Inst199910413421No
231013861386.034.7734.8The cancer stem cell: premises, promises and challenges. Hans CleversNat Med201121386835No
231127711385.588.5644.3The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. W R Gibb, A J LeesJ Neurol Neurosurg Psychiatry19882841426No
231227701385.056.6928.3'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? George Davey Smith, Shah EbrahimInt J Epidemiol200312689998No
231341541384.787.8729.3Multidrug resistance in cancer: role of ATP-dependent transporters. Michael M Gottesman, Tito Fojo, Susan E BatesNat Rev Cancer200211902585No
231441531384.3194.2764.8Risk factors for falls among elderly persons living in the community. M E Tinetti, M Speechley, S F GinterN Engl J Med19883205267Yes
231513841384.028.2528.2Origin of concatemeric T7 DNA. J D WatsonNat New Biol19724507727Yes
231613841384.046.5546.5Interleukin-1. C A DinarelloRev Infect Dis19846369481No
231713841384.030.0830.1Target-oriented and diversity-oriented organic synthesis in drug discovery. S L SchreiberScience200010720315No
231813841384.037.7437.7The pollution of the marine environment by plastic debris: a review. José G B DerraikMar Pollut Bull200212405208No
231927671383.5110.0355.0Cisplatin in cancer therapy: molecular mechanisms of action. Shaloam Dasari, Paul Bernard TchounwouEur J Pharmacol201425058905No
232041461382.0111.0937.0TCS: a computer program to estimate gene genealogies. M Clement, D Posada, K A CrandallMol Ecol200011050560Yes
232127641382.084.0142.0An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. O Johnell, J A KanisOsteoporos Int200616983459Yes
232213821382.00.00.0Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. W C SchneiderJ Biol Chem194818886166Yes
232355281382.0204.0851.0FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs SchoffelenComput Intell Neurosci201121253357Yes
232413821382.044.3144.3The role of autophagy in neurodegenerative disease. Ralph A NixonNat Med201323921753No
232513811381.059.0959.1Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. T SpectorAnal Biochem1978655375Yes
232613811381.031.1631.2Molecular basis of long-term plasticity underlying addiction. E J NestlerNat Rev Neurosci200111252991No
232713811381.035.9536.0Genetic consequences of climatic oscillations in the Quaternary. G M HewittPhilos Trans R Soc Lond B Biol Sci200415101575No
232841411380.383.8427.9The versatility and universality of calcium signalling. M J Berridge, P Lipp, M D BootmanNat Rev Mol Cell Biol200011413485No
232913801380.018.7618.8Hippocampal electrical activity and voluntary movement in the rat. C H VanderwolfElectroencephalogr Clin Neurophysiol19694183562Yes
233041401380.0119.6939.9Validation of the Insomnia Severity Index as an outcome measure for insomnia research. C H. Bastien, A Vallières, C M. MorinSleep Med200111438246Yes
233113801380.034.9234.9Diagnosis of osteoporosis and assessment of fracture risk. John A KanisLancet200212057569No
233227581379.095.4947.7A new scale of social desirability independent of psychopathology. D P Crowne, D MarloweJ Consult Psychol196013813058Yes
233313791379.029.3529.4A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Dale R NyholtAm J Hum Genet200414997420Yes
233427581379.0109.5854.8Natural products as sources of new drugs over the 30 years from 1981 to 2010. David J Newman, Gordon M CraggJ Nat Prod201222316239No
233568931378.6254.4650.9Evidence based medicine: what it is and what it isn't. D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S RichardsonBMJ19968555924No
233613781378.030.630.6Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. M KozakMicrobiol Rev19836343825No
233713771377.021.8921.9Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. J R DavidProc Natl Acad Sci U S A19665229858Yes
233827541377.079.9740.0Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. C J Murray, A D LopezLancet19979164317Yes
233941301376.7136.6345.5Global estimates of the prevalence of diabetes for 2010 and 2030. J E Shaw, R A Sicree, P Z ZimmetDiabetes Res Clin Pract201019896746Yes
234027511375.599.3949.7Biology of disease: free radicals and tissue injury. B A Freeman, J D CrapoLab Invest19826290784No
234127511375.570.4135.2Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. D Marion, K WüthrichBiochem Biophys Res Commun19836307308Yes
234213751375.035.3535.4The human orbitofrontal cortex: linking reward to hedonic experience. Morten L KringelbachNat Rev Neurosci200516136173No
234327491374.573.6936.8Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Robert E W Hancock, Hans-Georg SahlNat Biotechnol200617160061No
234427481374.077.5538.8Mortality by cause for eight regions of the world: Global Burden of Disease Study. C J Murray, A D LopezLancet19979142060Yes
234513741374.044.4344.4Synopsis of some recent tactical application of bioisosteres in drug design. Nicholas A MeanwellJ Med Chem201121413808Yes
234654951373.8211.9653.0Bayesian phylogenetics with BEAUti and the BEAST 1.7. Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew RambautMol Biol Evol201222367748Yes
234713731373.028.3228.3Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. R I MorimotoGenes Dev19989869631No
234827461373.068.3334.2Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. Felix Krueger, Simon R AndrewsBioinformatics201121493656Yes
234982351372.5269.4844.9Antioxidant activity applying an improved ABTS radical cation decolorization assay. R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-EvansFree Radic Biol Med199910381194Yes
235013721372.024.2724.3The snail superfamily of zinc-finger transcription factors. M Angela NietoNat Rev Mol Cell Biol200211994736No
235113721372.039.9239.9Depression in late life: review and commentary. Dan G BlazerJ Gerontol A Biol Sci Med Sci200312634292No
235213721372.00.00.0Effects of varying the vehicle for OsO4 in tissue fixation. J B CaulfieldJ Biophys Biochem Cytol195713475399Yes
235327441372.071.1335.6EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. Stefan Stoll, Arthur SchweigerJ Magn Reson200616188474Yes
235441151371.798.0132.7Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Daniel Falush, Matthew Stephens, Jonathan K PritchardGenetics200312930761Yes
235527431371.555.2527.6Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. A J Berk, P A SharpCell1977922889Yes
235641141371.3118.4239.5Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Garnier, D J Osguthorpe, B RobsonJ Mol Biol1978642007Yes
235713711371.00.00.0An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. O SmithiesBiochem J195913638269Yes
235813711371.041.3341.3Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. Chao-Jun LiAcc Chem Res200919220064Yes
235941111370.3139.8846.6Factor structure of the Barratt impulsiveness scale. J H Patton, M S Stanford, E S BarrattJ Clin Psychol19958778124Yes
236013701370.047.0847.1Multiple calcium channels and neuronal function. R J MillerScience19872432656No
236113701370.032.2232.2Regulation of differentiation of vascular smooth muscle cells. G K OwensPhysiol Rev19957624392No
236213701370.039.0839.1Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. P WillnerPsychopharmacology (Berl)19979452163No
236327401370.080.5440.3Physiological time-series analysis using approximate entropy and sample entropy. J S Richman, J R MoormanAm J Physiol Heart Circ Physiol200010843903Yes
236413701370.049.1149.1The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. Eleonore FröhlichInt J Nanomedicine201223144561No
236541091369.791.5630.5OrthoMCL: identification of ortholog groups for eukaryotic genomes. Li Li, Christian J Stoeckert, David S RoosGenome Res200312952885Yes
236627391369.567.8733.9Myocardial reperfusion injury. Derek M Yellon, Derek J HausenloyN Engl J Med200717855673No
236713691369.042.4742.5The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. L W SwansonBrain Res Bull19826816390Yes
236813691369.012.3312.3Immunological function of the thymus. J F MillerLancet196114474038Yes
236968421368.4198.5739.7Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939839Yes
237013681368.025.9225.9Epithelial-mesenchymal transitions in development and pathologies. Jean Paul ThieryCurr Opin Cell Biol200314644200No
237113681368.031.8831.9Huntington's disease. Francis O WalkerLancet200717240289No
237227351367.584.9842.5A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. R L Juliano, V LingBiochim Biophys Acta1976990323Yes
237327311365.593.2446.6Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. D H Figurski, D R HelinskiProc Natl Acad Sci U S A1979377280Yes
237427311365.580.440.2The Measurement Of Selection On Correlated Characters. Russell Lande, Stevan J ArnoldEvolution198328556011Yes
237513651365.031.4131.4Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? Rui WangFASEB J200212409322Yes
237613651365.043.3743.4Amino acids: metabolism, functions, and nutrition. Guoyao WuAmino Acids200919301095No
237713651365.034.534.5Mitochondrial fusion and fission in cell life and death. Benedikt WestermannNat Rev Mol Cell Biol201021102612No
237813641364.022.3122.3Cancer. Addiction to oncogenes--the Achilles heal of cancer. I Bernard WeinsteinScience200212098689No
237913631363.028.128.1Stability and flexibility of epigenetic gene regulation in mammalian development. Wolf ReikNature200717522676No
238013631363.00.00.0The generalisation of student's problems when several different population variances are involved. B L WelchBiometrika194720287819Yes
238127251362.572.9836.5Antibiotic resistance of bacteria in biofilms. P S Stewart, J W CostertonLancet200111463434No
238213621362.032.7832.8Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. G von HeijneJ Mol Biol19921593632Yes
238327221361.052.2426.1A protein sequenator. P Edman, G BeggEur J Biochem19676059350Yes
238413601360.064.4464.4Molecular pathology of schizophrenia: more than one disease process? T J CrowBr Med J19806101544No
238513601360.049.5749.6The structure of beta-lactamases. R P AmblerPhilos Trans R Soc Lond B Biol Sci19806109327Yes
238627201360.081.3840.7Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. D Filmer, L H PritchettDemography200111227840Yes
238727191359.595.6647.8A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. C M Tsai, C E FraschAnal Biochem19826176137Yes
238827191359.555.4627.7Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. J M Kyriakis, J AvruchPhysiol Rev200111274345No
238927191359.566.5333.3Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. M P Lutolf, J A HubbellNat Biotechnol200515637621No
239027181359.057.7928.9LTP and LTD: an embarrassment of riches. Robert C Malenka, Mark F BearNeuron200415450156No
239127161358.062.6131.3NF-kappa B: ten years after. P A Baeuerle, D BaltimoreCell19968858144No
239213581358.056.356.3The global burden of IBD: from 2015 to 2025. Gilaad G KaplanNat Rev Gastroenterol Hepatol201526323879No
239327151357.574.7737.4miRBase: integrating microRNA annotation and deep-sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201121037258Yes
239413571357.035.8835.9Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. P LipsEndocr Rev200111493580No
239513561356.052.9452.9Blood gas calculator. J W SeveringhausJ Appl Physiol19665912737Yes
239613561356.029.8629.9Diarylethenes for Memories and Switches. Masahiro IrieChem Rev200011777416Yes
239740671355.790.8730.3Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. Christian W Tornøe, Caspar Christensen, Morten MeldalJ Org Chem200211975567Yes
239813551355.027.1327.1Dimerization of cell surface receptors in signal transduction. C H HeldinCell19957834741No
239913551355.024.1624.2Chromatin modification and epigenetic reprogramming in mammalian development. En LiNat Rev Genet200212209141No
240040651355.036.5112.2Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. D D Sabatini, K Bensch, R J BarrnettJ Cell Biol196313975866Yes
240127091354.553.826.9Prediction of complete gene structures in human genomic DNA. C Burge, S KarlinJ Mol Biol19979149143Yes
240227091354.50.00.0The respiratory chain and oxidative phosphorylation. B Chance, G R WilliamsAdv Enzymol Relat Subj Biochem195613313307Yes
240313541354.028.3228.3Stereological principles for morphometry in electron microscopic cytology. E R WeibelInt Rev Cytol19694899604No
240427071353.5125.5862.8Glutathione peroxidase activity in selenium-deficient rat liver. R A Lawrence, R F BurkBiochem Biophys Res Commun1976971321Yes
240527071353.562.5331.3Emerging roles of caspase-3 in apoptosis. A G Porter, R U JänickeCell Death Differ199910200555No
240627061353.067.6233.8The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Clay B Holroyd, Michael G H ColesPsychol Rev200212374324Yes
240767651353.0164.7833.0Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory CollinsLancet200212493255Yes
240813521352.022.7722.8The origin of the genetic code. F H CrickJ Mol Biol19684887876Yes
240913521352.043.2643.3History of the Rochester Epidemiology Project. L J MeltonMayo Clin Proc19968594285No
241013521352.036.3836.4Atopic dermatitis. Thomas BieberN Engl J Med200818385500Yes
241181091351.5203.4133.9A default mode of brain function. M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L ShulmanProc Natl Acad Sci U S A200111209064Yes
241213511351.041.1741.2Neurotransmitters and neuromodulators in the basal ganglia. A M GraybielTrends Neurosci19901695398No
241313511351.042.6542.6Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. J J GrossJ Pers Soc Psychol19989457784Yes
241454041351.0127.6931.9The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten SchwedeBioinformatics200616301204Yes
241527011350.565.2332.6Regulation mechanisms and signaling pathways of autophagy. Congcong He, Daniel J KlionskyAnnu Rev Genet200919653858No
241627011350.558.8329.4NMR View: A computer program for the visualization and analysis of NMR data. B A Johnson, R A BlevinsJ Biomol NMR199422911360Yes
241713501350.034.5734.6The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. R G KhalifahJ Biol Chem19714994926Yes
241853981349.5124.8131.2Quantitative monitoring of gene expression patterns with a complementary DNA microarray. M Schena, D Shalon, R W Davis, P O BrownScience19957569999Yes
241913491349.042.7242.7Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. A A GraceNeuroscience19911676137No
242013491349.045.3645.4Functional organization of central pathways regulating the cardiovascular system. R A DampneyPhysiol Rev19948171117No
242113491349.035.6235.6Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. S L FriedmanN Engl J Med19938502273No
242213481348.042.242.2Renin-angiotensin system: biochemistry and mechanisms of action. M J PeachPhysiol Rev1977191856No
242326961348.075.7837.9The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. W L Jorgensen, J Tirado-RivesJ Am Chem Soc198827557051Yes
242426951347.590.7645.4Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. G J Miller, N E MillerLancet197546338Yes
242526951347.565.9533.0The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Daniel J Drucker, Michael A NauckLancet200617098089No
242613471347.042.442.4Glutathione metabolism and its selective modification. A MeisterJ Biol Chem19883053703No
242713471347.039.1739.2Osteoblast adhesion on biomaterials. K AnselmeBiomaterials200010711964No
242840401346.7104.1534.7Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Robert D Schreiber, Lloyd J Old, Mark J SmythScience201121436444No
242926931346.561.0730.5Disruption of epithelial cell-matrix interactions induces apoptosis. S M Frisch, H FrancisJ Cell Biol19948106557Yes
243013461346.025.2725.3A modified procedure for lead staining of thin sections. G MillonigJ Biophys Biochem Cytol196114474176Yes
243113461346.037.8337.8Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. Felix KratzJ Control Release200818582981No
243226901345.061.9831.0Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. G Blobel, B DobbersteinJ Cell Biol1975811671Yes
243326901345.061.5530.8The RXR heterodimers and orphan receptors. D J Mangelsdorf, R M EvansCell19958521508No
243413451345.033.7733.8A molecular view of microbial diversity and the biosphere. N R PaceScience19979115194No
243540341344.7115.6538.6A rapid bootstrap algorithm for the RAxML Web servers. Alexandros Stamatakis, Paul Hoover, Jacques RougemontSyst Biol200818853362Yes
243613441344.026.0426.0Chromosomal translocations in human cancer. T H RabbittsNature19947969446No
243726881344.075.4337.7Epidemiology of invasive candidiasis: a persistent public health problem. M A Pfaller, D J DiekemaClin Microbiol Rev200717223626No
243813441344.00.00.0An approximate distribution of estimates of variance components. F E SatterthwaiteBiometrics194620287815Yes
243913431343.041.9642.0Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Thomas HebererToxicol Lett200211988354Yes
244013431343.027.4527.4The many faces of macrophage activation. David M MosserJ Leukoc Biol200312554797No
244113431343.00.00.0The critical incident technique. J C FlanaganPsychol Bull195413177800Yes
244213421342.042.2442.2The phenomenon of the acute phase response. I KushnerAnn N Y Acad Sci19827046585No
244313421342.028.4328.4HIF-1: mediator of physiological and pathophysiological responses to hypoxia. G L SemenzaJ Appl Physiol (1985)200010749844No
244413421342.052.8752.9AliView: a fast and lightweight alignment viewer and editor for large datasets. Anders LarssonBioinformatics201425095880Yes
244513411341.033.2333.2The biologic clock: the mitochondria? D HarmanJ Am Geriatr Soc19725016631Yes
244640231341.0100.6933.6LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. A C Wallace, R A Laskowski, J M ThorntonProtein Eng19957630882Yes
244713411341.042.2342.2Electrocatalyst approaches and challenges for automotive fuel cells. Mark K DebeNature201222678278Yes
244826801340.093.4646.7Total energy intake: implications for epidemiologic analyses. W Willett, M J StampferAm J Epidemiol19863521261No
244913401340.024.2424.2c-Myc target genes involved in cell growth, apoptosis, and metabolism. C V DangMol Cell Biol19999858526No
245026801340.078.8739.4A cognitive model of posttraumatic stress disorder. A Ehlers, D M ClarkBehav Res Ther200010761279No
245113401340.013.4813.5Cellular resistance to infection. G B MackanessJ Exp Med196214467923Yes
245213401340.00.00.0Notes on continuous stochastic phenomena. P A P MoranBiometrika195015420245Yes
245313401340.038.2638.3Cytokinesis-block micronucleus cytome assay. Michael FenechNat Protoc200717546000Yes
245493741339.1381.1854.5Development and validation of a geriatric depression screening scale: a preliminary report. J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O LeirerJ Psychiatr Res19827183759Yes
245513391339.035.6635.7Fibronectin and its receptors. E RuoslahtiAnnu Rev Biochem19882972252No
245613391339.047.3447.3Neuropeptide Y: complete amino acid sequence of the brain peptide. K TatemotoProc Natl Acad Sci U S A19826957876Yes
245713381338.035.035.0The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. K KuwajimaProteins19892695928No
245813381338.043.1643.2The amazing osteocyte. Lynda F BonewaldJ Bone Miner Res201121254230No
245913371337.048.0748.1Letter: Grading of angina pectoris. L CampeauCirculation1976947585Yes
246013371337.050.6650.7Translating social ecological theory into guidelines for community health promotion. D StokolsAm J Health Promot199610159709No
246113371337.035.8935.9Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. E B HunzikerOsteoarthritis Cartilage200212056848No
246213361336.025.6525.6microRNAs: tiny regulators with great potential. V AmbrosCell200111779458No
246326711335.554.3127.2Regulated portals of entry into the cell. Sean D Conner, Sandra L SchmidNature200312621426No
246426711335.559.7329.9A comparison of bayesian methods for haplotype reconstruction from population genotype data. Matthew Stephens, Peter DonnellyAm J Hum Genet200314574645Yes
246513351335.028.528.5The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. G B MorinCell19892805070Yes
246613351335.023.0323.0Protein modification by SUMO. Erica S JohnsonAnnu Rev Biochem200415189146No
246726691334.587.3443.7Origins and evolution of antibiotic resistance. Julian Davies, Dorothy DaviesMicrobiol Mol Biol Rev201020805405No
246813341334.029.229.2Physiological concentrations of purines and pyrimidines. T W TrautMol Cell Biochem19947877593No
246913341334.0139.13139.1A Review of Coronavirus Disease-2019 (COVID-19). Tanu SinghalIndian J Pediatr202032166607No
247013331333.028.6728.7Codon usage and tRNA content in unicellular and multicellular organisms. T IkemuraMol Biol Evol19853916708No
247113331333.029.3229.3Transcriptional control of adipocyte formation. Stephen R FarmerCell Metab200617011499No
247226641332.068.0834.0Further improvements in the plaque technique for detecting single antibody-forming cells. A J Cunningham, A SzenbergImmunology19685653817Yes
247313311331.039.3739.4Circuitry and functional aspects of the insular lobe in primates including humans. J R AugustineBrain Res Brain Res Rev19968957561No
247413311331.029.5729.6Physiological and molecular basis of thyroid hormone action. P M YenPhysiol Rev200111427693No
247513311331.025.6925.7Mechanisms of caspase activation and inhibition during apoptosis. Yigong ShiMol Cell200211931755No
247613301330.00.00.0A simple ultraviolet spectrophotometric method for the determination of protein. W J WaddellJ Lab Clin Med195613346201Yes
247753151328.8130.8732.7Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. D W Cleveland, S G Fischer, M W Kirschner, U K LaemmliJ Biol Chem1977320200Yes
247813281328.020.1920.2A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. A M OlovnikovJ Theor Biol19734754905Yes
247913281328.023.1723.2Regulatory T cells: key controllers of immunologic self-tolerance. S SakaguchiCell200010850488No
248013271327.034.5234.5The aryl hydrocarbon receptor complex. O HankinsonAnnu Rev Pharmacol Toxicol19957598497No
248126541327.060.3730.2Integrins and signal transduction pathways: the road taken. E A Clark, J S BruggeScience19957716514No
248213261326.033.6933.7Thioredoxin and glutaredoxin systems. A HolmgrenJ Biol Chem19892668278No
248313261326.031.7931.8Apoptosis in cancer therapy: crossing the threshold. D E FisherCell19948069905No
248413261326.029.9830.0Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. W D SniderCell19948205613No
248513261326.028.1928.2The enzymes, regulation, and genetics of bile acid synthesis. David W RussellAnnu Rev Biochem200312543708No
248626511325.548.8424.4Immunization of dissociated spleen cell cultures from normal mice. R I Mishell, R W DuttonJ Exp Med19676034749Yes
248766271325.4177.4635.5Transection of the oesophagus for bleeding oesophageal varices. R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R WilliamsBr J Surg19734541913Yes
248826501325.064.5232.3Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Uwe-Karsten Hanisch, Helmut KettenmannNat Neurosci200717965659No
248926491324.567.1233.6Therapeutic potential of resveratrol: the in vivo evidence. Joseph A Baur, David A SinclairNat Rev Drug Discov200616732220No
249079471324.5236.0439.3The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gøtzsche, Jan P VandenbrouckeLancet200718064739Yes
249126481324.054.5127.3Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. P J Southern, P BergJ Mol Appl Genet19826286831Yes
249213241324.032.8232.8N-heterocyclic carbenes: a new concept in organometallic catalysis. Wolfgang A HerrmannAngew Chem Int Ed Engl200219750753Yes
249326471323.572.5836.3A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. B G Durie, S E SalmonCancer19751182674Yes
249439701323.3107.135.7Nitric oxide and peroxynitrite in health and disease. Pál Pacher, Joseph S Beckman, Lucas LiaudetPhysiol Rev200717237348No
249513231323.050.9350.9Free-radical mechanisms in tissue injury. T F SlaterBiochem J19846383353No
249639681322.7102.5134.2Cognitive and emotional influences in anterior cingulate cortex. G Bush, P Luu, M I PosnerTrends Cogn Sci200010827444Yes
249713221322.024.6324.6Antigen-specific interaction between T and B cells. A LanzavecchiaNature19853157869Yes
249813221322.023.1523.1Clonal selection and learning in the antibody system. K RajewskyNature19968657279No
249913221322.00.00.0On the psychophysical law. S S StevensPsychol Rev195713441853Yes
250013221322.023.3923.4SUMO: a history of modification. Ronald T HayMol Cell200515808504No
250113221322.033.9534.0Microbial influences in inflammatory bowel diseases. R Balfour SartorGastroenterology200818242222No
250239651321.796.832.3Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. Y Zhang, M Brady, S SmithIEEE Trans Med Imaging200111293691Yes
250339641321.390.3730.1Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Witold Filipowicz, Suvendra N Bhattacharyya, Nahum SonenbergNat Rev Genet200818197166No
250439631321.097.3632.5The p53 tumour suppressor gene. A J Levine, J Momand, C A FinlayNature19912046748No
250513211321.063.3763.4The clinical application of the biopsychosocial model. G L EngelAm J Psychiatry19807369396Yes
250613211321.028.228.2Prediction of protein cellular attributes using pseudo-amino acid composition. K C ChouProteins200111288174Yes
250713211321.035.4335.4Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Arnold I CaplanJ Cell Physiol200717620285No
250826411320.555.5427.8Liver regeneration. G K Michalopoulos, M C DeFrancesScience19979082986No
250952811320.2116.8329.2Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J ThunN Engl J Med200312711737Yes
251013201320.034.4834.5Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. W W DouglasBr J Pharmacol19684882190No
251126381319.041.6520.8Functions of lysosomes. C De Duve, R WattiauxAnnu Rev Physiol19665322983No
251213191319.033.4133.4Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. R M SapolskyArch Gen Psychiatry200011015810No
251313181318.048.1348.1The life and times of the Enterococcus. B E MurrayClin Microbiol Rev19902404568No
251413181318.017.0917.1Disconnexion syndromes in animals and man. I. N GeschwindBrain19655318481No
251513181318.042.6942.7An application of prefrontal cortex function theory to cognitive aging. R L WestPsychol Bull19968831298No
251639521317.3209.1869.7Shedding light on the cell biology of extracellular vesicles. Guillaume van Niel, Gisela D'Angelo, Graça RaposoNat Rev Mol Cell Biol201829339798No
251726341317.0100.950.5Malondialdehyde determination as index of lipid peroxidation. H H Draper, M HadleyMethods Enzymol19902233309Yes
251826331316.590.5545.3Functional interactions between the gut microbiota and host metabolism. Valentina Tremaroli, Fredrik BäckhedNature201222972297No
251913161316.039.0739.1Classification of chronic viral hepatitis: a need for reassessment. P J ScheuerJ Hepatol19911808228No
252013161316.027.7927.8Double identity for proteins of the Bcl-2 family. J C ReedNature19979194558No
252113161316.029.0229.0Measuring information transfer T SchreiberPhys Rev Lett200010991308Yes
252213161316.00.00.0A quantitative immunochemical measure of the primary interaction between I BSA and antibody. R S FarrJ Infect Dis195813611294Yes
252313161316.051.3951.4What is self-rated health and why does it predict mortality? Towards a unified conceptual model. Marja JylhäSoc Sci Med200919520474Yes
252413161316.031.331.3Recent advances in neuroblastoma. John M MarisN Engl J Med201020558371No
252539471315.783.9528.0A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. R Medzhitov, P Preston-Hurlburt, C A JanewayNature19979237759Yes
252613151315.034.6434.6Phylogenies from molecular sequences: inference and reliability. J FelsensteinAnnu Rev Genet19883071258No
252713151315.065.1365.1Displaced proximal humeral fractures. I. Classification and evaluation. C S NeerJ Bone Joint Surg Am19705455339Yes
252839441314.7311.44103.8Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles. Aldenor G Santos, Gisele O da Rocha, Jailson B de AndradeSci Rep201930626917Yes
252913141314.036.8936.9The matrix-degrading metalloproteinases. L M MatrisianBioessays19921445287No
253013141314.028.5128.5Mechanisms of foxp3+ T regulatory cell-mediated suppression. Ethan M ShevachImmunity200919464986No
253126281314.081.7340.9CTFFIND4: Fast and accurate defocus estimation from electron micrographs. Alexis Rohou, Nikolaus GrigorieffJ Struct Biol201526278980Yes
253213131313.045.0745.1Carnitine--metabolism and functions. J BremerPhysiol Rev19836361812No
253313131313.030.0930.1Oxidative stress in neurodegeneration: cause or consequence? Julie K AndersenNat Med200415298006No
253426251312.548.8824.4New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. R D Gietz, A SuginoGene19883073106Yes
253526241312.096.348.1Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. E Engvall, P PerlmannJ Immunol19724113792Yes
253626231311.546.3423.2Rab proteins as membrane organizers. M Zerial, H McBrideNat Rev Mol Cell Biol200111252952No
253752461311.5123.8931.0Improved prediction of signal peptides: SignalP 3.0. Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren BrunakJ Mol Biol200415223320Yes
253852451311.2132.0233.0Universal sample preparation method for proteome analysis. Jacek R Wiśniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias MannNat Methods200919377485Yes
253926221311.058.1229.1Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Jane E Visvader, Geoffrey J LindemanNat Rev Cancer200818784658No
254039281309.3139.7446.6A new method for off-line removal of ocular artifact. G Gratton, M G Coles, E DonchinElectroencephalogr Clin Neurophysiol19836187540Yes
254113091309.033.8633.9Supported membranes: scientific and practical applications. E SackmannScience19968539599No
254226171308.559.3329.7Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. E Y Chen, P H SeeburgDNA19853996185Yes
254313081308.032.832.8Comparative physiology of salt and water stress. R. MunnsPlant Cell Environ200211841667Yes
254439241308.093.431.1Functional porous coordination polymers. Susumu Kitagawa, Ryo Kitaura, Shin-ichiro NoroAngew Chem Int Ed Engl200415114565Yes
254513081308.031.1531.1Non-Smad pathways in TGF-beta signaling. Ying E ZhangCell Res200919114990No
254626151307.561.1530.6Microenvironmental regulation of metastasis. Johanna A Joyce, Jeffrey W PollardNat Rev Cancer200919279573No
254713071307.00.00.0Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. P F ScholanderJ Biol Chem194720281644Yes
254826141307.071.3435.7Tumor metastasis: molecular insights and evolving paradigms. Scott Valastyan, Robert A WeinbergCell201122000009No
254926131306.540.3320.2The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. J Shine, L DalgarnoProc Natl Acad Sci U S A19744598299Yes
255013061306.069.8469.8Psychosocial resilience and protective mechanisms. Michael RutterAm J Orthopsychiatry19873303954No
255113061306.054.1754.2Error in medicine. L L LeapeJAMA19947503827Yes
255213061306.039.0439.0Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Thomas GrobnerNephrol Dial Transplant200616431890Yes
255313061306.026.8726.9Solving structures of protein complexes by molecular replacement with Phaser. Airlie J McCoyActa Crystallogr D Biol Crystallogr200717164524Yes
255413051305.023.6923.7CD95's deadly mission in the immune system. P H KrammerNature200011048730No
255513051305.0118.69118.7Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Jonas F LudvigssonActa Paediatr202032202343Yes
255626091304.5116.7458.4Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. J M Tanner, R H WhitehouseArch Dis Child1976952550Yes
255726081304.056.2528.1Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. M Zuker, P StieglerNucleic Acids Res19816163133Yes
255813031303.038.0938.1Qinghaosu (artemisinin): an antimalarial drug from China. D L KlaymanScience19853887571No
255913031303.029.5529.6Metastatic bone disease: clinical features, pathophysiology and treatment strategies. R E ColemanCancer Treat Rev200111417967No
256013031303.035.2635.3Polycystic ovary syndrome. David A EhrmannN Engl J Med200515788499No
256113031303.034.2834.3The sympathetic control of blood pressure. Patrice G GuyenetNat Rev Neurosci200616760914No
256226061303.063.3731.7Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Subhra K Biswas, Alberto MantovaniNat Immunol201020856220No
256339081302.780.5426.8Calcium signalling: dynamics, homeostasis and remodelling. Michael J Berridge, Martin D Bootman, H Llewelyn RoderickNat Rev Mol Cell Biol200312838335No
256413021302.031.2331.2Receptors for epidermal growth factor and other polypeptide mitogens. G CarpenterAnnu Rev Biochem19873039909No
256513021302.00.00.0The anterior approach for removal of ruptured cervical disks. R B ClowardJ Neurosurg195813599052Yes
256613021302.027.3927.4Human natural killer cells. Michael A CaligiuriBlood200818650461No
256713021302.032.4432.4Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. G L SemenzaOncogene201019946328No
256826031301.582.7841.4Epidermal growth factor. G Carpenter, S CohenAnnu Rev Biochem1979382984No
256926031301.543.7521.9Genetic transformation of Drosophila with transposable element vectors. G M Rubin, A C SpradlingScience19826289436Yes
257039041301.386.0728.7Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Axel Nimmerjahn, Frank Kirchhoff, Fritjof HelmchenScience200515831717Yes
257113011301.021.6621.7Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. W D HamiltonScience19676021675Yes
257239031301.090.6930.2Tissue cells feel and respond to the stiffness of their substrate. Dennis E Discher, Paul Janmey, Yu-Li WangScience200516293750No
257313011301.037.2837.3BEDTools: The Swiss-Army Tool for Genome Feature Analysis. Aaron R QuinlanCurr Protoc Bioinformatics201425199790Yes
257413001300.044.5544.5The theoretical bases of indirect calorimetry: a review. E FerranniniMetabolism19883278194No
257513001300.011.6811.7Metabolic stability and epigenesis in randomly constructed genetic nets. S A KauffmanJ Theor Biol19695803332Yes
257664971299.4250.2450.0Fsl. Mark Jenkinson, Christian F Beckmann, Timothy E J Behrens, Mark W Woolrich, Stephen M SmithNeuroimage201221979382No
257712991299.028.5528.6Long-term potentiation and memory. M A LynchPhysiol Rev200414715912No
257825981299.0105.8352.9A typology of reviews: an analysis of 14 review types and associated methodologies. Maria J Grant, Andrew BoothHealth Info Libr J200919490148No
257938961298.799.7433.2Atomic force microscope. G Binnig, C F Quate, C GerberPhys Rev Lett198610033323Yes
258012981298.029.8629.9The path to ubiquitous and low-cost organic electronic appliances on plastic. Stephen R ForrestNature200415118718Yes
258112981298.044.0144.0AmpC beta-lactamases. George A JacobyClin Microbiol Rev200919136439No
258212971297.043.6743.7Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. J H LuftAnat Rec19714108333Yes
258312971297.057.8157.8Machine Learning in Medicine. Rahul C DeoCirculation201526572668No
258425931296.561.6830.8Production of single-stranded plasmid DNA. J Vieira, J MessingMethods Enzymol19873323803Yes
258512961296.042.4242.4Optimal foraging, the marginal value theorem. E L CharnovTheor Popul Biol19761273796Yes
258625921296.0190.8695.4ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R. Emmanuel Paradis, Klaus SchliepBioinformatics201930016406Yes
258712951295.030.230.2Pathways of oxidative damage. James A ImlayAnnu Rev Microbiol200314527285No
258812951295.00.00.0On the local reactions of the arterial wall to changes of internal pressure. W M BaylissJ Physiol190216992618Yes
258925901295.094.4847.2Role of the microbiota in immunity and inflammation. Yasmine Belkaid, Timothy W HandCell201424679531No
259025891294.566.6733.3Apoptosis, oncosis, and necrosis. An overview of cell death. G Majno, I JorisAm J Pathol19957856735No
259125891294.555.8527.9Mitochondrial control of cell death. G Kroemer, J C ReedNat Med200010802706No
259212941294.060.1460.1Oxidative stress: a concept in redox biology and medicine. Helmut SiesRedox Biol201525588755No
259325871293.586.443.2Social conditions as fundamental causes of disease. B G Link, J PhelanJ Health Soc Behav19957560851No
259425871293.561.5630.8Multipoint quantitative-trait linkage analysis in general pedigrees. L Almasy, J BlangeroAm J Hum Genet19989545414Yes
259577591293.2196.5832.8Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat RoblesBioinformatics200516081474Yes
259612931293.057.0357.01,500 scientists lift the lid on reproducibility. Monya BakerNature201627225100No
259725851292.537.8918.9Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. J E Sulston, H R HorvitzDev Biol1977838129Yes
259864611292.2158.6931.7Enzymatic determination of total serum cholesterol. C C Allain, L S Poon, C S Chan, W Richmond, P C FuClin Chem19744818200Yes
259938761292.0101.1733.7Bacterial biofilms: from the natural environment to infectious diseases. Luanne Hall-Stoodley, J William Costerton, Paul StoodleyNat Rev Microbiol200415040259No
260051651291.2103.5325.9Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. D D Sarbassov, David A Guertin, Siraj M Ali, David M SabatiniScience200515718470Yes
260112911291.030.4930.5Lymphokine production by human T cells in disease states. S RomagnaniAnnu Rev Immunol19948011282No
260212911291.034.4734.5Sarcopenia: origins and clinical relevance. I H RosenbergJ Nutr19979164280No
260325811290.582.6941.3Tumor-associated macrophages: from mechanisms to therapy. Roy Noy, Jeffrey W PollardImmunity201425035953No
260425801290.082.1741.1Oxidative mechanisms in the toxicity of metal ions. S J Stohs, D BagchiFree Radic Biol Med19957744317No
260512901290.029.5529.6Oxyradicals and DNA damage. L J MarnettCarcinogenesis200010688856No
260612901290.00.00.0Limitations of the application of fourfold table analysis to hospital data. J BerksonBiometrics194621001024Yes
260725791289.558.9529.5Cell cycle, CDKs and cancer: a changing paradigm. Marcos Malumbres, Mariano BarbacidNat Rev Cancer200919238148No
260812891289.031.6831.7Surrogate endpoints in clinical trials: definition and operational criteria. R L PrenticeStat Med19892727467Yes
260912891289.037.9838.0Endometriosis. Serdar E BulunN Engl J Med200919144942No
261012881288.041.3141.3Bee and wasp venoms. E HabermannScience19724113805No
261112881288.040.5740.6Thermal properties of graphene and nanostructured carbon materials. Alexander A BalandinNat Mater201121778997Yes
261225751287.587.6943.8Regulatory sequences involved in the promotion and termination of RNA transcription. M Rosenberg, D CourtAnnu Rev Genet197994251No
261325751287.571.0235.5What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? K C Berridge, T E RobinsonBrain Res Brain Res Rev19989858756No
261412871287.033.0933.1Psychological and neural mechanisms of the affective dimension of pain. D D PriceScience200010846154No
261512871287.032.7532.8Pain and emotion interactions in subregions of the cingulate gyrus. Brent A VogtNat Rev Neurosci200515995724No
261664341286.8121.5724.3Crystal structure of the nucleosome core particle at 2.8 A resolution. K Luger, A W Mäder, R K Richmond, D F Sargent, T J RichmondNature19979305837Yes
261725731286.5158.3579.2Facial nerve grading system. J W House, D E BrackmannOtolaryngol Head Neck Surg19853921901Yes
261825721286.075.0337.5Prediction of the secondary structure of proteins from their amino acid sequence. P Y Chou, G D FasmanAdv Enzymol Relat Areas Mol Biol1978364941No
261925721286.065.4132.7Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. J A Ledbetter, L A HerzenbergImmunol Rev1979398327No
262012861286.035.1935.2The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. R G GerrityAm J Pathol19817234961Yes
262112861286.027.2127.2The stem-cell niche as an entity of action. David T ScaddenNature200616810242No
262212851285.038.9138.9Diversity and ubiquity of K channels. B RudyNeuroscience19882457185No
262312851285.027.3327.3Sustainable hydrogen production. John A TurnerScience200415310892Yes
262412851285.029.0629.1Refined structure of the nicotinic acetylcholine receptor at 4A resolution. Nigel UnwinJ Mol Biol200515701510Yes
262525691284.566.4533.2Establishment and characterization of a human histiocytic lymphoma cell line (U-937). C Sundström, K NilssonInt J Cancer1976178611Yes
262638531284.386.9729.0Photodynamic therapy for cancer. Dennis E J G J Dolmans, Dai Fukumura, Rakesh K JainNat Rev Cancer200312724736No
262712841284.029.0929.1Chemistry and biology of the immunophilins and their immunosuppressive ligands. S L SchreiberScience19911702904No
262812841284.037.5137.5Electrophoretic separation of plasma lipoproteins in agarose gel. R P NobleJ Lipid Res19684176473Yes
262912841284.059.5959.6Cardiovascular and renal actions of dopamine: potential clinical applications. L I GoldbergPharmacol Rev19724554480No
263012841284.031.7331.7Overview of general physiologic features and functions of vitamin D. Hector F DeLucaAm J Clin Nutr200415585789No
263112841284.029.6129.6Tumour necrosis factor and cancer. Frances BalkwillNat Rev Cancer200919343034No
263212831283.055.1155.1Rhythms for Cognition: Communication through Coherence. Pascal FriesNeuron201526447583No
263338481282.790.6330.2Evolution and functions of long noncoding RNAs. Chris P Ponting, Peter L Oliver, Wolf ReikCell200919239885No
263451291282.2223.5555.9Progressive statistics for studies in sports medicine and exercise science. William G Hopkins, Stephen W Marshall, Alan M Batterham, Juri HaninMed Sci Sports Exerc200919092709No
263512821282.014.3914.4A restriction point for control of normal animal cell proliferation. A B PardeeProc Natl Acad Sci U S A19744524638Yes
263612821282.030.6130.6Papillomavirus infections--a major cause of human cancers. H zur HausenBiochim Biophys Acta19968876633No
263725641282.055.127.6The pathophysiology of mitochondrial cell death. Douglas R Green, Guido KroemerScience200415286356No
263812821282.037.1437.1Species concepts and species delimitation. Kevin De QueirozSyst Biol200718027281Yes
263925641282.056.4728.2Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. S W Hell, J WichmannOpt Lett199419844443Yes
264025631281.546.7123.4Live or let die: the cell's response to p53. Karen H Vousden, Xin LuNat Rev Cancer200212154352No
264125631281.546.0823.0DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Christopher J Bakkenist, Michael B KastanNature200312556884Yes
2642140961281.5380.6534.6The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J RoccellaJAMA200312748199No
264312811281.039.4539.5Somatostatin. S ReichlinN Engl J Med19836139753No
264425621281.0129.1464.6A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. M Roland, R MorrisSpine (Phila Pa 1976)19836222486Yes
264512811281.028.3428.3Liver fibrosis -- from bench to bedside. Scott L FriedmanJ Hepatol200312591185No
264612811281.026.926.9Neuroligins and neurexins link synaptic function to cognitive disease. Thomas C SüdhofNature200818923512No
264712801280.032.1332.1The mitochondrial electron transport and oxidative phosphorylation system. Y HatefiAnnu Rev Biochem19852862839No
264812801280.043.1143.1Density matrix formulation for quantum renormalization groups. S R WhitePhys Rev Lett199210046608Yes
264925601280.00.00.0Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. H A Edmondson, P E SteinerCancer195413160935Yes
265012801280.041.1941.2How stigma interferes with mental health care. Patrick CorriganAm Psychol200415491256Yes
265112801280.00.00.0The antidiuretic hormone and the factors which determine its release. E B VerneyProc R Soc Lond B Biol Sci194718918876Yes
265212791279.046.6546.6Substance P. B PernowPharmacol Rev19836196797No
265312791279.044.344.3PaDEL-descriptor: an open source software to calculate molecular descriptors and fingerprints. Chun Wei YapJ Comput Chem201121425294Yes
265489491278.4253.5336.2Cancer statistics, 2008. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J ThunCA Cancer J Clin200818287387Yes
265512781278.079.9479.9A comparison of canal preparations in straight and curved root canals. S W SchneiderOral Surg Oral Med Oral Pathol19715284110Yes
265625561278.063.4731.7Interneurons of the hippocampus. T F Freund, G BuzsákiHippocampus19968915675No
265712781278.023.9123.9Mobile elements: drivers of genome evolution. Haig H KazazianScience200415016989No
265812781278.073.2173.2DLS and zeta potential - What they are and what they are not? Sourav BhattacharjeeJ Control Release201627297779No
265938331277.7127.1142.4Rehospitalizations among patients in the Medicare fee-for-service program. Stephen F Jencks, Mark V Williams, Eric A ColemanN Engl J Med200919339721Yes
266012771277.028.5528.6Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. T A SpringerAnnu Rev Physiol19957778885No
266125541277.052.5826.3The molecular biology of axon guidance. M Tessier-Lavigne, C S GoodmanScience19968895455No
266212771277.038.738.7Chronic disease management: what will it take to improve care for chronic illness? E H WagnerEff Clin Pract199810345255No
266325541277.061.1430.6C-reactive protein: a critical update. Mark B Pepys, Gideon M HirschfieldJ Clin Invest200312813013No
266412771277.00.00.0Agammaglobulinemia. O C BrutonPediatrics195214929630Yes
266525541277.056.5728.3ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking. Matthew D Wilkerson, D Neil HayesBioinformatics201020427518Yes
266625531276.561.7230.9Drug delivery systems: entering the mainstream. Theresa M Allen, Pieter R CullisScience200415031496Yes
266738291276.3143.4647.8Complex heatmaps reveal patterns and correlations in multidimensional genomic data. Zuguang Gu, Roland Eils, Matthias SchlesnerBioinformatics201627207943Yes
266812761276.060.8660.9New norms of upper limb fat and muscle areas for assessment of nutritional status. A R FrisanchoAm J Clin Nutr19816975564Yes
266925521276.062.6731.3The free radical theory of aging matures. K B Beckman, B N AmesPhysiol Rev19989562038No
267012761276.031.5331.5Hydrogen sulphide and its therapeutic potential. Csaba SzabóNat Rev Drug Discov200717948022No
267125511275.523.6511.8Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Altman, G D DasJ Comp Neurol19655861717Yes
267225511275.50.00.0Construct validity in psychological tests. L J Cronbach, P E MeehlPsychol Bull195513245896Yes
267325511275.554.7327.4The canonical Notch signaling pathway: unfolding the activation mechanism. Raphael Kopan, Maria Xenia G IlaganCell200919379690No
267425491274.575.2237.6Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. A Dahlstroem, K FuxeActa Physiol Scand Suppl196414229500Yes
267512741274.025.5725.6Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. R H SchwartzCell19921335362No
267612741274.030.7830.8Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. A BöyumScand J Clin Lab Invest Suppl19684179066Yes
267725481274.067.5533.8Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Ajay Kumar Gupta, Mona GuptaBiomaterials200515626447No
267812731273.020.8920.9Antigen receptor tail clue. M RethNature19892927501Yes
267912731273.055.7255.7Biomaterial-centered infection: microbial adhesion versus tissue integration. A G GristinaScience19873629258Yes
268012731273.022.4122.4The molecular motor toolbox for intracellular transport. Ronald D ValeCell200312600311No
268112731273.032.1332.1Plasmonics: merging photonics and electronics at nanoscale dimensions. Ekmel OzbayScience200616410515Yes
268212731273.026.8526.9Recognition and processing of ubiquitin-protein conjugates by the proteasome. Daniel FinleyAnnu Rev Biochem200919489727No
268312731273.00.00.0Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. H M KalckarJ Biol Chem194720285041Yes
268425451272.549.5624.8A rapid, sensitive, and specific method for the determination of protein in dilute solution. W Schaffner, C WeissmannAnal Biochem19734128882Yes
268525451272.563.1931.6Neuronal plasticity: increasing the gain in pain. C J Woolf, M W SalterScience200010846153No
268625451272.567.1833.6Integrins in cancer: biological implications and therapeutic opportunities. Jay S Desgrosellier, David A ChereshNat Rev Cancer201020029421No
268712721272.044.6644.7Plasma perspective on strong field multiphoton ionization. P B CorkumPhys Rev Lett199310054556Yes
268812721272.034.3934.4Neural simulation of action: a unifying mechanism for motor cognition. M JeannerodNeuroimage200111373140No
268976301271.7191.3531.9An obesity-associated gut microbiome with increased capacity for energy harvest. Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I GordonNature200617183312Yes
269038151271.7135.9845.3Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Marina Colombo, Graça Raposo, Clotilde ThéryAnnu Rev Cell Dev Biol201425288114No
269125431271.548.8724.4Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. M Fried, D M CrothersNucleic Acids Res19816275366Yes
269225421271.059.1429.6Quorum sensing in bacteria. M B Miller, B L BasslerAnnu Rev Microbiol200111544353No
269312711271.033.833.8The biochemistry and medical significance of the flavonoids. Bent H HavsteenPharmacol Ther200212453566No
269412711271.034.3434.3How brains beware: neural mechanisms of emotional attention. Patrik VuilleumierTrends Cogn Sci200516289871Yes
269512711271.041.2741.3The epidemiology of adult obstructive sleep apnea. Naresh M PunjabiProc Am Thorac Soc200818250205No
269612711271.0118.23118.2COVID-19 and African Americans. Clyde W YancyJAMA202032293639Yes
269725411270.556.6628.3The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. P M Sharp, W H LiNucleic Acids Res19873547335Yes
269812701270.029.2229.2The prefrontal cortex and cognitive control. E K MillerNat Rev Neurosci200011252769No
269912701270.038.5638.6Persister cells. Kim LewisAnnu Rev Microbiol201020528688No
270050801270.0185.0346.3The chemistry and applications of metal-organic frameworks. Hiroyasu Furukawa, Kyle E Cordova, Michael O'Keeffe, Omar M YaghiScience201323990564Yes
270125391269.557.1528.6Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. D A Brown, J K RoseCell19921531449Yes
270225391269.573.2736.6Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. Aluísio J D Barros, Vânia N HirakataBMC Med Res Methodol200314567763Yes
270312691269.034.8134.8Tumor angiogenesis. J FolkmanAdv Cancer Res19852581424No
270412691269.024.8724.9Structure and function of intercellular junctions. L A StaehelinInt Rev Cytol19744611943No
270525371268.576.0638.0An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Sun Ho Kim, Jin Mo ChungPain19921333581Yes
270625371268.558.6329.3Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Kornelia Polyak, Robert A WeinbergNat Rev Cancer200919262571No
270712681268.040.540.5Tumor delivery of macromolecular drugs based on the EPR effect. Vladimir TorchilinAdv Drug Deliv Rev201120304019No
270812681268.054.3554.4Environmentally induced oxidative stress in aquatic animals. Volodymyr I LushchakAquat Toxicol201121074869No
270912681268.036.6536.6Deconvoluting the context-dependent role for autophagy in cancer. Eileen WhiteNat Rev Cancer201222534666No
271025351267.581.1940.6Surgical risk as related to time of intervention in the repair of intracranial aneurysms. W E Hunt, R M HessJ Neurosurg19685635959Yes
271138011267.0169.4556.5In search of how people change. Applications to addictive behaviors. J O Prochaska, C C DiClemente, J C NorcrossAm Psychol19921329589Yes
271238011267.090.5230.2Dystrophin: the protein product of the Duchenne muscular dystrophy locus. E P Hoffman, R H Brown, L M KunkelCell19873319190Yes
271312671267.025.8925.9Endocytosis and molecular sorting. I MellmanAnnu Rev Cell Dev Biol19968970738No
271412671267.029.9329.9Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Hiroshi TakayanagiNat Rev Immunol200717380158No
271512661266.030.5130.5Short-term synaptic plasticity. R S ZuckerAnnu Rev Neurosci19892648947No
271650641266.0111.9928.0A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry SharplessAngew Chem Int Ed Engl200212203546Yes
271712651265.032.1932.2Rapid evolution of a protein in vitro by DNA shuffling. W P StemmerNature19948047147Yes
271812651265.034.9935.0Regulation of glutathione synthesis. Shelly C LuMol Aspects Med200918601945No
271937941264.7103.0634.4Molecular characterization of a peripheral receptor for cannabinoids. S Munro, K L Thomas, M Abu-ShaarNature19937689702Yes
272025291264.59.714.9Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. G J Todaro, H GreenJ Cell Biol196313985244Yes
272125291264.577.0138.5Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Christine Vogel, Edward M MarcotteNat Rev Genet201222411467No
272212641264.026.0226.0Signal transduction via the MAP kinases: proceed at your own RSK. J BlenisProc Natl Acad Sci U S A19938392180No
272325281264.095.3347.7Liposomal drug delivery systems: from concept to clinical applications. Theresa M Allen, Pieter R CullisAdv Drug Deliv Rev201323036225No
272412641264.054.8254.8Transcriptional architecture of the mammalian circadian clock. Joseph S TakahashiNat Rev Genet201727990019No
272512631263.031.5531.6Apoptosis. J J CohenImmunol Today19938466628No
272625251262.562.1531.1Pharmacology and functions of metabotropic glutamate receptors. P J Conn, J P PinAnnu Rev Pharmacol Toxicol19979131252No
272725251262.544.5622.3The DNA damage response: putting checkpoints in perspective. B B Zhou, S J ElledgeNature200011100718No
272825251262.551.5725.8Tumorigenesis and the angiogenic switch. Gabriele Bergers, Laura E BenjaminNat Rev Cancer200312778130No
272912621262.026.3926.4Nucleic acid junctions and lattices. N C SeemanJ Theor Biol19826188926Yes
273012621262.041.9742.0Phenylpropanoid biosynthesis. Thomas VogtMol Plant201020035037No
273112611261.025.825.8SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. S V EvansJ Mol Graph19938347566Yes
273212611261.025.2925.3Searching for genetic determinants in the new millennium. N J RischNature200010866211No
273325221261.077.6538.8Modeling and comparison of dissolution profiles. P Costa, J M Sousa LoboEur J Pharm Sci200111297896No
273412611261.021.5421.5Cancer susceptibility and the functions of BRCA1 and BRCA2. Ashok R VenkitaramanCell200211832208No
273537821260.7127.0342.3Job burnout. C Maslach, W B Schaufeli, M P LeiterAnnu Rev Psychol200111148311Yes
273612601260.033.7733.8Signaling through phosphatidylcholine breakdown. J H ExtonJ Biol Chem19902104616No
273712601260.036.236.2A Wilcoxon-type test for trend. J CuzickStat Med19853992076Yes
273825201260.079.5639.8Molecular and cellular insights into T cell exhaustion. E John Wherry, Makoto KurachiNat Rev Immunol201526205583No
273925191259.548.9724.5CpG islands in vertebrate genomes. M Gardiner-Garden, M FrommerJ Mol Biol19873656447Yes
274012591259.031.2431.2Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. J DeisenhoferBiochemistry19817236608Yes
274112591259.031.5331.5The effective period of preventive antibiotic action in experimental incisions and dermal lesions. J F BurkeSurgery196116722001Yes
274225171258.566.8833.4Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. J L Weber, P E MayAm J Hum Genet19892916582Yes
274325171258.556.2728.1Can the pharmaceutical industry reduce attrition rates? Ismail Kola, John LandisNat Rev Drug Discov200415286737No
274412581258.027.8327.8Life, death, and the pursuit of apoptosis. E WhiteGenes Dev19968557188No
274537741258.089.9730.0Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Christopher R Genovese, Nicole A Lazar, Thomas NicholsNeuroimage200211906227Yes
274612581258.00.00.0A simple objective technique for measuring flexibility in thinking. E A BergJ Gen Psychol194818889466Yes
274712571257.035.8835.9Strategy and tactics in protein chemistry. B S HartleyBiochem J19704923920No
274825141257.067.3633.7Chlorophyll fluorescence--a practical guide. K Maxwell, G N JohnsonJ Exp Bot200010938857No
274912571257.029.5429.5Reactive oxygen radicals in signaling and damage in the ischemic brain. P H ChanJ Cereb Blood Flow Metab200111149664No
275025131256.564.1632.1Hydrogels for tissue engineering: scaffold design variables and applications. Jeanie L Drury, David J MooneyBiomaterials200312922147No
275137681256.0111.1737.1The functional anatomy of basal ganglia disorders. R L Albin, A B Young, J B PenneyTrends Neurosci19892479133No
275212561256.036.0136.0Peptide antibiotics and their role in innate immunity. H G BomanAnnu Rev Immunol19957612236No
275350231255.8144.7336.2Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Weidner, J P Semple, W R Welch, J FolkmanN Engl J Med19911701519Yes
275425111255.572.8236.4Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. J I Morgan, T CurranAnnu Rev Neurosci19911903243No
275525111255.5152.4176.2A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. E S Grood, W J SuntayJ Biomech Eng19836865355Yes
275612551255.035.5735.6Plant productivity and environment. J S BoyerScience198217808529Yes
275712551255.062.4862.5Biological roles of glycans. Ajit VarkiGlycobiology201727558841No
275812541254.024.8424.8STATs: signal transducers and activators of transcription. J N IhleCell19968608586No
275925061253.047.0323.5The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. T Maehama, J E DixonJ Biol Chem19989593664Yes
276012531253.029.8429.8Somatostatin and its receptor family. Y C PatelFront Neuroendocrinol199910433861No
276125051252.557.9229.0DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. S Tabor, C C RichardsonProc Natl Acad Sci U S A19873474623Yes
276225051252.550.8925.4ERBB receptors and cancer: the complexity of targeted inhibitors. Nancy E Hynes, Heidi A LaneNat Rev Cancer200515864276No
276325051252.568.5134.3Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Taro Kawai, Shizuo AkiraImmunity201121616434No
276412521252.042.1542.1Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. R LotanBiochim Biophys Acta19806989400No
276512521252.027.1527.1S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. R DonatoInt J Biochem Cell Biol200111390274No
276625011250.579.7939.9DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI. Yan Chao-Gan, Zang Yu-FengFront Syst Neurosci201020577591Yes
276737511250.3112.037.3Oxidants, antioxidants, and the degenerative diseases of aging. B N Ames, M K Shigenaga, T M HagenProc Natl Acad Sci U S A19938367443No
276837511250.3104.034.7Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Günter Oberdörster, Eva Oberdörster, Jan OberdörsterEnviron Health Perspect200516002369No
276912501250.042.6742.7Inhibition and facilitation of nucleic acid amplification. I G WilsonAppl Environ Microbiol19979327537No
277012501250.034.1134.1Internal models for motor control and trajectory planning. M KawatoCurr Opin Neurobiol199910607637No
277112501250.026.0126.0The roles of intracellular protein-degradation pathways in neurodegeneration. David C RubinszteinNature200617051204No
277224991249.548.7424.4Gene silencing in cancer in association with promoter hypermethylation. James G Herman, Stephen B BaylinN Engl J Med200314627790No
277312491249.023.623.6Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. P RakicJ Comp Neurol19714101340Yes
277424981249.062.931.4Nanostructures in biodiagnostics. Nathaniel L Rosi, Chad A MirkinChem Rev200515826019No
277524971248.5213.1106.5Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. R B Gustilo, J T AndersonJ Bone Joint Surg Am1976773941Yes
277637451248.3142.3247.4Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis. Christopher K Prier, Danica A Rankic, David W C MacMillanChem Rev201323509883No
277712481248.082.7882.8The problem of rigor in qualitative research. M SandelowskiANS Adv Nurs Sci19863083765Yes
277812481248.062.7162.7Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. Anna Maria CarlssonPain19836602967Yes
277924961248.068.7834.4Nitric oxide synthases: roles, tolls, and controls. C Nathan, Q W XieCell19947522969No
278012481248.032.9833.0Persister cells, dormancy and infectious disease. Kim LewisNat Rev Microbiol200717143318No
278124951247.561.6530.8Hydrogels for tissue engineering. K Y Lee, D J MooneyChem Rev200111710233No
278249901247.5116.0529.0Autophagy fights disease through cellular self-digestion. Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J KlionskyNature200818305538No
278349891247.2104.9726.2Interleukin-10 and the interleukin-10 receptor. K W Moore, R de Waal Malefyt, R L Coffman, A O'GarraAnnu Rev Immunol200111244051No
278412471247.057.4757.5A cognitive approach to panic. D M ClarkBehav Res Ther19863741311Yes
278512471247.030.2530.2Electrochemiluminescence (ECL). Mark M RichterChem Rev200415186186No
278612471247.034.734.7Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. P VestergaardOsteoporos Int200717068657No
278712471247.038.338.3Understanding diagnostic tests 3: Receiver operating characteristic curves. Anthony K AkobengActa Paediatr200717376185No
2788137141246.7328.3429.8New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G GwytherJ Natl Cancer Inst200010655437No
278974801246.7215.7136.0Free radicals and antioxidants in normal physiological functions and human disease. Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua TelserInt J Biochem Cell Biol200716978905No
279012461246.034.6334.6The effects of stressful life events on depression. R C KesslerAnnu Rev Psychol19979046559No
279112461246.026.6726.7Molecular physiology of low-voltage-activated t-type calcium channels. Edward Perez-ReyesPhysiol Rev200312506128No
279212451245.041.9441.9How is the level of free arachidonic acid controlled in mammalian cells? R F IrvineBiochem J19826810878No
279312451245.00.00.0Intra-sexual selection in Drosophila. A J BatemanHeredity (Edinb)194818103134Yes
279424881244.061.6730.8Molecular mechanisms of action of steroid/thyroid receptor superfamily members. M J Tsai, B W O'MalleyAnnu Rev Biochem19947979245No
279524881244.063.2731.6Genetic dissection of complex traits. E S Lander, N J SchorkScience19948091226No
279612441244.032.6432.6The lipocalin protein family: structure and function. D R FlowerBiochem J19968761444No
279712441244.024.3724.4Cytokines induce the development of functionally heterogeneous T helper cell subsets. A O'GarraImmunity19989529145No
279812441244.030.8130.8Optimal experimental design for event-related fMRI. A M DaleHum Brain Mapp199910524601Yes
279924871243.565.5632.8Epidemiology and outcomes of osteoporotic fractures. Steven R Cummings, L Joseph MeltonLancet200212049882No
280012431243.030.2130.2Primate anterior cingulate cortex: where motor control, drive and cognition interface. T PausNat Rev Neurosci200111389475No
280112431243.00.00.0A modification of receptor theory. R P StephensonBr J Pharmacol Chemother195613383117Yes
280212421242.037.8537.9Calcium channel modulation by neurotransmitters, enzymes and drugs. H ReuterNature19836131381No
280324841242.090.3245.2The stunned myocardium: prolonged, postischemic ventricular dysfunction. E Braunwald, R A KlonerCirculation19826754130No
280412421242.032.6532.6Thermo- and pH-responsive polymers in drug delivery. Dirk SchmaljohannAdv Drug Deliv Rev200617125884No
280512411241.030.2430.2Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. P KuzmicAnal Biochem19968660575Yes
280624821241.064.6132.3Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Barry J Everitt, Trevor W RobbinsNat Neurosci200516251991No
280712411241.090.590.5SARS-CoV-2 vaccines in development. Florian KrammerNature202032967006No
280824811240.594.3347.2Cronbach's alpha. J M Bland, D G AltmanBMJ19979055718Yes
280937201240.0116.2738.8MR diffusion tensor spectroscopy and imaging. P J Basser, J Mattiello, D LeBihanBiophys J19948130344Yes
281012401240.035.835.8Invasive aspergillosis. D W DenningClin Infect Dis19989564455No
281112401240.038.0938.1Risk and maintenance factors for eating pathology: a meta-analytic review. Eric SticePsychol Bull200212206196No
281237191239.787.2129.1Global and societal implications of the diabetes epidemic. P Zimmet, K G Alberti, J ShawNature200111742409No
281324791239.562.5331.3Epidemiology of Parkinson's disease. Lonneke M L de Lau, Monique M B BretelerLancet Neurol200616713924No
281412391239.035.2935.3Varieties of impulsivity. J L EvendenPsychopharmacology (Berl)199910550486No
281512391239.028.3828.4Optical microcavities. Kerry J VahalaNature200312917698Yes
281637141238.0135.7345.2Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. C J Caspersen, K E Powell, G M ChristensonPublic Health Rep19853920711Yes
281712381238.026.0426.0Antigen-presenting function of the macrophage. E R UnanueAnnu Rev Immunol19846242349No
281812381238.028.1128.1Evaluating medication effects outside of clinical trials: new-user designs. Wayne A RayAm J Epidemiol200314585769Yes
281924741237.047.9124.0Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. C W Greider, E H BlackburnCell19853907856Yes
282012371237.027.4427.4Neurobiology of Pavlovian fear conditioning. S MarenAnnu Rev Neurosci200111520922No
282161851237.0248.1949.6The Phyre2 web portal for protein modeling, prediction and analysis. Lawrence A Kelley, Stefans Mezulis, Christopher M Yates, Mark N Wass, Michael J E SternbergNat Protoc201525950237Yes
282224731236.555.7527.9Cellular processing of platinum anticancer drugs. Dong Wang, Stephen J LippardNat Rev Drug Discov200515789122No
282324721236.0102.1751.1Reading senseless sentences: brain potentials reflect semantic incongruity. M Kutas, S A HillyardScience19807350657Yes
282412361236.00.00.0The relation of the trail making test to organic brain damage. R M ReitanJ Consult Psychol195513263471Yes
282524721236.053.4226.7The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. B N Ames, D T DubinJ Biol Chem196013793161Yes
282624721236.066.3833.2Meeting of minds: the medial frontal cortex and social cognition. David M Amodio, Chris D FrithNat Rev Neurosci200616552413No
282712361236.031.2431.2Polymer conjugates as anticancer nanomedicines. Ruth DuncanNat Rev Cancer200616900224No
282812361236.031.1131.1TNF-mediated inflammatory disease. J R BradleyJ Pathol200818161752No
282912361236.038.7638.8Nanobodies: natural single-domain antibodies. Serge MuyldermansAnnu Rev Biochem201323495938No
283024711235.553.1126.6Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Eugenia E Calle, Rudolf KaaksNat Rev Cancer200415286738No
283124711235.579.2839.6The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. Julie D Henry, John R CrawfordBr J Clin Psychol200516004657Yes
283212351235.031.6631.7Drug delivery and targeting. R LangerNature19989579855No
283312351235.034.7534.8Targeting recovery: priorities of the spinal cord-injured population. Kim D AndersonJ Neurotrauma200415672628Yes
283424691234.548.2824.1Checkpoints: controls that ensure the order of cell cycle events. L H Hartwell, T A WeinertScience19892683079No
283512341234.026.3626.4Assortative mixing in networks. M E J NewmanPhys Rev Lett200212443515Yes
283624671233.547.8723.9Proliferation, cell cycle and apoptosis in cancer. G I Evan, K H VousdenNature200111357141No
283724671233.567.7833.9The cognitive control of emotion. Kevin N Ochsner, James J GrossTrends Cogn Sci200515866151No
283812331233.051.2751.3A cochlear frequency-position function for several species--29 years later. D D GreenwoodJ Acoust Soc Am19902373794Yes
283912331233.032.4432.4Low density lipoprotein oxidation and its pathobiological significance. D SteinbergJ Biol Chem19979261091No
284012331233.035.6335.6Subcutaneous and visceral adipose tissue: structural and functional differences. M Mohsen IbrahimObes Rev201019656312No
284112331233.040.4640.5Function and information content of DNA methylation. Dirk SchübelerNature201525592537No
284224661233.0103.8151.9Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Roel Nusse, Hans CleversCell201728575679No
284324641232.068.3334.2Ageing and Parkinson's disease: substantia nigra regional selectivity. J M Fearnley, A J LeesBrain19911933245Yes
284412321232.031.9231.9Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Earl S FordDiabetes Care200515983333No
284561581231.6192.9538.6Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. J S Beckman, T W Beckman, J Chen, P A Marshall, B A FreemanProc Natl Acad Sci U S A19902154753Yes
284624631231.564.9432.5A review of central 5-HT receptors and their function. N M Barnes, T SharpNeuropharmacology199910462127No
284736941231.371.423.8Exosomes: composition, biogenesis and function. Clotilde Théry, Laurence Zitvogel, Sebastian AmigorenaNat Rev Immunol200212154376No
284824621231.066.1533.1Increasing incidence of thyroid cancer in the United States, 1973-2002. Louise Davies, H Gilbert WelchJAMA200616684987Yes
284912311231.033.3833.4Infection in solid-organ transplant recipients. Jay A FishmanN Engl J Med200718094380No
285036921230.7115.1538.4Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. B K Matuszewski, M L Constanzer, C M Chavez-EngAnal Chem200312964746Yes
285112301230.038.4638.5Antioxidants in human health and disease. B HalliwellAnnu Rev Nutr19968839918No
285212301230.022.8122.8Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Ricky W JohnstoneNat Rev Drug Discov200212120280No
285386091229.9253.7436.2Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E MarshStroke19937678184Yes
285449171229.2130.1232.5Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S VasanStat Med200817569110Yes
285512291229.021.9722.0Mutation selection and the natural history of cancer. J CairnsNature19751143315Yes
285612291229.031.4431.4Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. P O SeglenExp Cell Res19734358115Yes
285712291229.018.6918.7The concept of immunological surveillance. F M BurnetProg Exp Tumor Res19704921480No
285812291229.00.00.0Sequential tests for the detection of linkage. N E MortonAm J Hum Genet195513258560Yes
285986011228.7217.6731.1Integrative genomics viewer. James T Robinson, Helga Thorvaldsdóttir, Wendy Winckler, Mitchell Guttman, Eric S Lander, Gad Getz, Jill P MesirovNat Biotechnol201121221095Yes
286012281228.044.0844.1Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. R M PostAm J Psychiatry19921353322No
286112281228.055.2455.2Continuous improvement as an ideal in health care. D M BerwickN Engl J Med19892909878Yes
286212281228.028.6228.6A likelihood approach to estimating phylogeny from discrete morphological character data. P O LewisSyst Biol200112116640Yes
286312281228.026.5626.6Nuclear factor-kappaB: the enemy within. Bharat B AggarwalCancer Cell200415380510No
286424561228.062.3131.2An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Gary Aston-Jones, Jonathan D CohenAnnu Rev Neurosci200516022602No
286524551227.554.1827.1Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. G K McMaster, G G CarmichaelProc Natl Acad Sci U S A197773185Yes
286624541227.063.2731.6Biology of incretins: GLP-1 and GIP. Laurie L Baggio, Daniel J DruckerGastroenterology200717498508No
286724531226.539.3219.7A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. D Tautz, C PfeifleChromosoma19892476281Yes
286824531226.556.8328.4Peroxisome proliferator-activated receptors: nuclear control of metabolism. B Desvergne, W WahliEndocr Rev199910529898No
286912261226.033.1833.2Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. U MitzdorfPhysiol Rev19853880898No
287012261226.047.3947.4Minority stress and mental health in gay men. I H MeyerJ Health Soc Behav19957738327Yes
287112261226.030.7330.7Endothelial-leukocyte adhesion molecules. M P BevilacquaAnnu Rev Immunol19938476577No
287224521226.048.8524.4Community structure in social and biological networks. M Girvan, M E J NewmanProc Natl Acad Sci U S A200212060727No
287324521226.043.3221.7Stats: transcriptional control and biological impact. David E Levy, J E DarnellNat Rev Mol Cell Biol200212209125No
287412261226.026.1726.2Microglia as a source and target of cytokines. Uwe-Karsten HanischGlia200212379902No
287512251225.025.3625.4MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. R N GermainCell19948293464No
287636751225.0103.234.4The Patient Health Questionnaire-2: validity of a two-item depression screener. Kurt Kroenke, Robert L Spitzer, Janet B W WilliamsMed Care200314583691Yes
287712251225.026.3426.3Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nicholas C DenkoNat Rev Cancer200819143055No
287812251225.041.6941.7Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. Rui WangPhysiol Rev201222535897No
287912241224.045.7145.7A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. S T TiffanyPsychol Rev19902186423No
288012241224.043.6543.6The LMS method for constructing normalized growth standards. T J ColeEur J Clin Nutr19902354692Yes
288112241224.022.322.3Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. H E RuleyNature19836308473Yes
288212241224.026.6626.7Heterotrimeric G proteins: organizers of transmembrane signals. E J NeerCell19957834744No
288361181223.6280.2256.0BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs. Felipe A Simão, Robert M Waterhouse, Panagiotis Ioannidis, Evgenia V Kriventseva, Evgeny M ZdobnovBioinformatics201526059717Yes
288436701223.3109.2936.4Health benefits of physical activity: the evidence. Darren E R Warburton, Crystal Whitney Nicol, Shannon S D BredinCMAJ200616534088No
288548921223.0274.6868.7Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. L A Papile, J Burstein, R Burstein, H KofflerJ Pediatr1978305471Yes
288624431221.565.2732.6Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. M A Pfeffer, E BraunwaldCirculation19902138525No
288712211221.062.9763.0Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. K SatohClin Chim Acta1978719890Yes
288812211221.030.7830.8Neural systems for recognizing emotion. Ralph AdolphsCurr Opin Neurobiol200212015233No
288912211221.027.6827.7Production of recombinant protein therapeutics in cultivated mammalian cells. Florian M WurmNat Biotechnol200415529164No
289012211221.037.0937.1Delirium in older persons. Sharon K InouyeN Engl J Med200616540616No
289112211221.028.7228.7Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. R Balfour SartorNat Clin Pract Gastroenterol Hepatol200616819502No
289212211221.039.7639.8Photoplethysmography and its application in clinical physiological measurement. John AllenPhysiol Meas200717322588No
289312201220.048.4448.4Bone "mass" and the "mechanostat": a proposal. H M FrostAnat Rec19873688455Yes
289412201220.033.7433.7Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. F HeftiJ Neurosci19863746405Yes
289512201220.044.5244.5Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants. R W BohannonAge Ageing19979143432Yes
289612201220.030.7730.8Functionalized acenes and heteroacenes for organic electronics. John E AnthonyChem Rev200617165682Yes
289724391219.578.6539.3Atomic structure and chemistry of human serum albumin. X M He, D C CarterNature19921630489Yes
289824391219.519.219.6The Aggregation Of Blood Platelets. G V Born, M J CrossJ Physiol196314056485Yes
289912191219.044.5644.6Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. S H SafeCrit Rev Toxicol19948037844No
290012191219.023.5723.6Lipid rafts: elusive or illusive? Sean MunroCell200314622593No
290112191219.023.1223.1ChIP-seq: advantages and challenges of a maturing technology. Peter J ParkNat Rev Genet200919736561No
290212191219.045.9846.0Microtiter dish biofilm formation assay. George A O'TooleJ Vis Exp201121307833Yes
290312191219.034.6634.7T follicular helper cell differentiation, function, and roles in disease. Shane CrottyImmunity201425367570No
290412181218.028.5928.6Growth factors and cancer. S A AaronsonScience19911659742No
290524361218.075.4237.7Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J E Hixson, D T VernierJ Lipid Res19902341813Yes
290612181218.029.2629.3Plant salt tolerance. J K ZhuTrends Plant Sci200111173290Yes
290712181218.020.0620.1The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. G A RoseBull World Health Organ196213974778Yes
290812181218.037.4137.4Evaluating the quality of medical care. 1966. Avedis DonabedianMilbank Q200516279964No
290912171217.044.6444.6The P300 wave of the human event-related potential. T W PictonJ Clin Neurophysiol19921464675No
291012171217.032.1232.1Measurement of feelings using visual analogue scales. R C AitkenProc R Soc Med19694899510No
291112171217.022.1522.1Kinesin and dynein superfamily proteins and the mechanism of organelle transport. N HirokawaScience19989438838No
291212171217.025.0725.1Platelets in atherothrombosis. Zaverio M RuggeriNat Med200212411949No
291312171217.00.00.0The cytoarchitectonic organization of the spinal cord in the cat. B RexedJ Comp Neurol195214946260Yes
291412171217.034.5334.5Electrochemical glucose biosensors. Joseph WangChem Rev200818154363No
291536491216.361.5820.5A system for stable expression of short interfering RNAs in mammalian cells. Thijn R Brummelkamp, René Bernards, Reuven AgamiScience200211910072Yes
291612161216.059.1359.1ROC methodology in radiologic imaging. C E MetzInvest Radiol19863095258No
291712161216.025.7125.7Dendritic cells: unique leukocyte populations which control the primary immune response. D N HartBlood19979345009No
291812161216.027.327.3Brain tumors. L M DeAngelisN Engl J Med200111150363No
291912161216.024.3924.4Basement membranes: structure, assembly and role in tumour angiogenesis. Raghu KalluriNat Rev Cancer200312778132No
292012161216.066.9867.0ROS Are Good. Ron MittlerTrends Plant Sci201727666517No
292124301215.039.6419.8High resolution acrylamide gel electrophoresis of histones. S Panyim, R ChalkleyArch Biochem Biophys19695778650Yes
292212151215.027.0727.1Translating cell biology into therapeutic advances in Alzheimer's disease. D J SelkoeNature199910392577No
292324301215.047.9624.0Molecular chaperones in the cytosol: from nascent chain to folded protein. F Ulrich Hartl, Manajit Hayer-HartlScience200211884745No
292412141214.043.0643.1Experience from a multicentre stroke register: a preliminary report. S HatanoBull World Health Organ19761088404Yes
292512141214.032.632.6Levels of racism: a theoretic framework and a gardener's tale. C P JonesAm J Public Health200010936998Yes
292612141214.033.4333.4Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Antoine BecharaNat Neurosci200516251988No
292712141214.034.8534.9High prevalence of vitamin D inadequacy and implications for health. Michael F HolickMayo Clin Proc200616529140No
292824281214.072.9936.5Inflammatory mechanisms in obesity. Margaret F Gregor, Gökhan S HotamisligilAnnu Rev Immunol201121219177No
292912131213.042.142.1Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. A J AlpertJ Chromatogr19902324207Yes
293012131213.035.8435.8Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. Louis B RiceJ Infect Dis200818419525No
293124261213.086.8943.4Nitric oxide synthases: regulation and function. Ulrich Förstermann, William C SessaEur Heart J201221890489No
293212131213.051.8751.9The Laboratory Rat: Relating Its Age With Human's. Pallav SenguptaInt J Prev Med201323930179Yes
293312121212.033.8233.8Water as an active constituent in cell biology. Philip BallChem Rev200818095715No
293424231211.564.2132.1A neurotrophic model for stress-related mood disorders. Ronald S Duman, Lisa M MonteggiaBiol Psychiatry200616631126No
293512111211.024.924.9Morphogenetic roles of classic cadherins. M TakeichiCurr Opin Cell Biol19958573335No
293612101210.029.3429.3Bcl-2 initiates a new category of oncogenes: regulators of cell death. S J KorsmeyerBlood19921498330No
293712101210.028.7528.8Rapid and sensitive sequence comparison with FASTP and FASTA. W R PearsonMethods Enzymol19902156132Yes
293812101210.029.3929.4The neuropathology of schizophrenia. A critical review of the data and their interpretation. P J HarrisonBrain199910219775No
293912101210.010.8110.8Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. J M Van RossumArch Int Pharmacodyn Ther196313996119Yes
2940133041209.5340.5131.0Frailty in older adults: evidence for a phenotype. L P Fried, C M Tangen, J Walston, A B Newman, C Hirsch, J Gottdiener, T Seeman, R Tracy, W J Kop, G Burke, M A McBurnieJ Gerontol A Biol Sci Med Sci200111253156Yes
294112091209.038.1738.2Linkage map of Escherichia coli K-12, edition 7. B J BachmannMicrobiol Rev19836348505No
294212091209.025.1425.1Caspase structure, proteolytic substrates, and function during apoptotic cell death. D W NicholsonCell Death Differ199910578171No
294312091209.037.937.9Clinical practice. Endometriosis. Linda C GiudiceN Engl J Med201020573927No
294424171208.597.2548.6The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. R Näätänen, T PictonPsychophysiology19873615753Yes
294524171208.552.7726.4Toll-like receptors in innate immunity. Kiyoshi Takeda, Shizuo AkiraInt Immunol200515585605No
294612081208.032.2132.2Akaike's information criterion in generalized estimating equations. W PanBiometrics200111252586Yes
294772481208.0135.2922.5Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T TuschlNature200111373684Yes
294812081208.031.031.0The complex role of estrogens in inflammation. Rainer H StraubEndocr Rev200717640948No
294924161208.086.843.4Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. John F Cryan, Timothy G DinanNat Rev Neurosci201222968153No
295012071207.031.5931.6Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Paul WillnerNeuropsychobiology200516037678No
295136191206.372.6424.2Large-scale analysis of the yeast proteome by multidimensional protein identification technology. M P Washburn, D Wolters, J R YatesNat Biotechnol200111231557Yes
295212061206.028.2828.3Intracellular protein topogenesis. G BlobelProc Natl Acad Sci U S A19806929499Yes
295312061206.048.4148.4Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. E H BeacheyJ Infect Dis19817014727No
295412061206.023.1123.1IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Yong-Jun LiuAnnu Rev Immunol200515771572No
295524111205.559.9430.0Rising incidence of hepatocellular carcinoma in the United States. H B El-Serag, A C MasonN Engl J Med199910072408Yes
295636131204.3101.6433.9Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. H King, R E Aubert, W H HermanDiabetes Care19989727886Yes
295760211204.2146.9229.4Jalview Version 2--a multiple sequence alignment editor and analysis workbench. Andrew M Waterhouse, James B Procter, David M A Martin, Michèle Clamp, Geoffrey J BartonBioinformatics200919151095Yes
295812041204.037.7437.7Assay of intestinal disaccharidases. A DahlqvistAnal Biochem19685636962Yes
295912041204.048.9949.0The variable nature of cognitive control: a dual mechanisms framework. Todd S BraverTrends Cogn Sci201222245618Yes
296096311203.9249.2231.2A method and server for predicting damaging missense mutations. Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R SunyaevNat Methods201020354512Yes
296136091203.0177.7259.2Assessing coping strategies: a theoretically based approach. C S Carver, M F Scheier, J K WeintraubJ Pers Soc Psychol19892926629Yes
296212031203.027.227.2Mitochondrial transport of cations: channels, exchangers, and permeability transition. P BernardiPhysiol Rev199910508231No
296312031203.019.9820.0Mitotic kinases as regulators of cell division and its checkpoints. E A NiggNat Rev Mol Cell Biol200111413462No
296412031203.038.5838.6The Danish Register of Causes of Death. Karin Helweg-LarsenScand J Public Health201121775346Yes
296512031203.052.7652.8Inflammation, metaflammation and immunometabolic disorders. Gökhan S HotamisligilNature201728179656No
296612021202.031.9331.9The emotional dog and its rational tail: a social intuitionist approach to moral judgment. J HaidtPsychol Rev200111699120Yes
296724021201.073.9137.0A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. A Ennaceur, J DelacourBehav Brain Res19883228475Yes
296812011201.021.3821.4Studies on phosphatidylcholine vesicles. Formation and physical characteristics. C HuangBiochemistry19695777332Yes
296912011201.029.4729.5Automatic quantitation of localized in vivo 1H spectra with LCModel. S W ProvencherNMR Biomed200111410943Yes
297024021201.057.228.6Principles of bioactive lipid signalling: lessons from sphingolipids. Yusuf A Hannun, Lina M ObeidNat Rev Mol Cell Biol200818216770No
297112011201.050.4150.4The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults. L S RadloffJ Youth Adolesc199124265004Yes
297236021200.7113.3737.8Qualitative research in health care. Analysing qualitative data. C Pope, S Ziebland, N MaysBMJ200010625273No
297336011200.386.5528.8Functional diversity of helper T lymphocytes. A K Abbas, K M Murphy, A SherNature19968893001No
297447991199.8111.5827.9Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. G L Wang, B H Jiang, E A Rue, G L SemenzaProc Natl Acad Sci U S A19957539918Yes
297523991199.570.8735.4Recent advances in the phencyclidine model of schizophrenia. D C Javitt, S R ZukinAm J Psychiatry19911654746No
297623991199.553.5826.8Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. T Hunter, B M SeftonProc Natl Acad Sci U S A19806246487Yes
297723991199.564.132.0Leukocyte-endothelial adhesion molecules. T M Carlos, J M HarlanBlood19947522621No
297823991199.563.1731.6Imaging cognition II: An empirical review of 275 PET and fMRI studies. R Cabeza, L NybergJ Cogn Neurosci200010769304No
297923991199.5246.37123.2The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. Hussin A Rothan, Siddappa N ByrareddyJ Autoimmun202032113704No
298011991199.052.452.4Campylobacter enteritis: a "new" disease. M B SkirrowBr Med J1977871765Yes
298111991199.038.1838.2The pathogenesis of sepsis. R C BoneAnn Intern Med19911872494No
298211991199.025.6125.6The finer things in X-ray diffraction data collection. J W PflugrathActa Crystallogr D Biol Crystallogr199910531521Yes
298311991199.037.1237.1Sensorimotor integration in human postural control. R J PeterkaJ Neurophysiol200212205132Yes
298411991199.037.5737.6Socioeconomic status and obesity. Lindsay McLarenEpidemiol Rev200717478442No
298523981199.068.5634.3Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. Xiaobo Chen, Samuel S MaoChem Rev200717590053Yes
298647941198.5153.2438.3Validation of a combined comorbidity index. M Charlson, T P Szatrowski, J Peterson, J GoldJ Clin Epidemiol19947722560Yes
298711981198.024.5624.6Fibrotic disease and the T(H)1/T(H)2 paradigm. Thomas A WynnNat Rev Immunol200415286725No
298847891197.2132.2333.1Toxic potential of materials at the nanolevel. Andre Nel, Tian Xia, Lutz Mädler, Ning LiScience200616456071No
298911971197.060.9661.0Rating scales to assess depression in school-aged children. M KovacsActa Paedopsychiatr19817025571Yes
299011971197.030.6730.7Physiology and pathophysiology of purinergic neurotransmission. Geoffrey BurnstockPhysiol Rev200717429044No
299111971197.044.8844.9The evolving concept of health literacy. Don NutbeamSoc Sci Med200818952344Yes
299223931196.5127.6263.8Sensitivity Analysis in Observational Research: Introducing the E-Value. Tyler J VanderWeele, Peng DingAnn Intern Med201728693043Yes
299311961196.040.9641.0The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. N M KaplanArch Intern Med19892662932No
299411961196.025.9125.9An overview of epithelio-mesenchymal transformation. E D HayActa Anat (Basel)19958714286No
299511961196.028.028.0Matrix proteoglycans: from molecular design to cellular function. R V IozzoAnnu Rev Biochem19989759499No
299623911195.582.0341.0Factors affecting wound healing. S Guo, L A DipietroJ Dent Res201020139336No
299723911195.596.0748.0Unique features of long non-coding RNA biogenesis and function. Jeffrey J Quinn, Howard Y ChangNat Rev Genet201626666209No
299811951195.028.6328.6Metabolism and functions of glutathione in brain. R DringenProg Neurobiol200010880854No
299911951195.031.0731.1Q-ball imaging. David S TuchMagn Reson Med200415562495Yes
300011941194.048.9649.0Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). S SafeCrit Rev Toxicol19902124811No
300111941194.036.7636.8Biosynthesis and metabolism of endothelium-derived nitric oxide. L J IgnarroAnnu Rev Pharmacol Toxicol19902188578No
300211941194.036.0236.0The mysteries of lipoprotein(a). G UtermannScience19892530631No
300311941194.020.4420.4Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J O HolloszyJ Biol Chem19674290225Yes
300447751193.8130.4432.6Measurement of the elastic properties and intrinsic strength of monolayer graphene. Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James HoneScience200818635798Yes
300511931193.029.6129.6Hereditary cancer, oncogenes, and antioncogenes. A G KnudsonCancer Res19852983882Yes
300623861193.058.0729.0Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. M E Feder, G E HofmannAnnu Rev Physiol199910099689No
300747691192.2183.7145.9Predicting effective microRNA target sites in mammalian mRNAs. Vikram Agarwal, George W Bell, Jin-Wu Nam, David P BartelElife201526267216Yes
300811921192.046.5846.6Geriatric Depression Scale. J A YesavagePsychopharmacol Bull19883249773Yes
300911921192.027.0427.0Hybridization of denatured RNA transferred or dotted nitrocellulose paper. P S ThomasMethods Enzymol19836194404Yes
301011921192.033.2633.3Papillary and follicular thyroid carcinoma. M J SchlumbergerN Engl J Med19989445411No
301111921192.020.8120.8Stem cells: units of development, units of regeneration, and units in evolution. I L WeissmanCell200010647940No
301211921192.053.6153.6The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. W G DuncombeClin Chim Acta196414122498Yes
301311921192.030.0130.0Molecular genetics of colorectal cancer. Eric R FearonAnnu Rev Pathol201121090969No
301411921192.034.5934.6MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Amy E PasquinelliNat Rev Genet201222411466No
301523831191.549.124.6NF-kappaB: linking inflammation and immunity to cancer development and progression. Michael Karin, Florian R GretenNat Rev Immunol200516175180No
301623821191.045.5122.8Dynamic instability of microtubule growth. T Mitchison, M KirschnerNature19846504138Yes
301735731191.073.0324.3Toll-like receptors: critical proteins linking innate and acquired immunity. S Akira, K Takeda, T KaishoNat Immunol200111477402No
301811911191.00.00.0Histological demonstration of mucin after periodic acid. J F A McMANUSNature194620995486Yes
301911911191.059.3959.4The new statistics: why and how. Geoff CummingPsychol Sci201424220629Yes
302023811190.549.4524.7Atherosclerosis. the road ahead. C K Glass, J L WitztumCell200111239408No
302123811190.569.5934.8Natural products as sources of new drugs over the last 25 years. David J Newman, Gordon M CraggJ Nat Prod200717309302No
302223811190.566.5633.3New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. Jonathan B Baell, Georgina A HollowayJ Med Chem201020131845Yes
302311901190.032.7532.8Diversity of group types, regulation, and function of phospholipase A2. E A DennisJ Biol Chem19948175726No
302411901190.033.8933.9Atomic layer deposition: an overview. Steven M GeorgeChem Rev201019947596Yes
302547591189.8137.4234.4Place navigation impaired in rats with hippocampal lesions. R G Morris, P Garrud, J N Rawlins, J O'KeefeNature19827088155Yes
302623791189.547.6223.8Of mice and not men: differences between mouse and human immunology. Javier Mestas, Christopher C W HughesJ Immunol200414978070No
302747581189.5238.9559.7Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. Xiang Wan, Wenqian Wang, Jiming Liu, Tiejun TongBMC Med Res Methodol201425524443Yes
302823781189.0112.2156.1Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. J D Peuler, G A JohnsonLife Sci1977904439Yes
302911891189.032.7932.8Normalization of cell responses in cat striate cortex. D J HeegerVis Neurosci19921504027Yes
303011891189.021.5421.5Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. D HanahanNature19852986015Yes
3031106981188.7354.039.3A novel potent vasoconstrictor peptide produced by vascular endothelial cells. M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T MasakiNature19882451132Yes
303211881188.034.5634.6Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. W SieghartPharmacol Rev19957568326No
303323761188.043.9422.0Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. C Li, W H WongProc Natl Acad Sci U S A200111134512Yes
303411881188.019.2919.3Themes and variations on ubiquitylation. A M WeissmanNat Rev Mol Cell Biol200111265246No
303511881188.022.2522.2Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. G D WinterNature196214007593Yes
303611871187.034.8334.8The structure of common mental disorders. R F KruegerArch Gen Psychiatry199910530634Yes
303759331186.6198.6439.7Posttraumatic stress disorder in the National Comorbidity Survey. R C Kessler, A Sonnega, E Bromet, M Hughes, C B NelsonArch Gen Psychiatry19957492257Yes
303823721186.072.8736.4Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. A Warshel, M LevittJ Mol Biol1976985660Yes
303959301186.0141.1628.2Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L CoffmanJ Immunol19862419430Yes
3040166001185.7353.9225.3Crystallography & NMR system: A new software suite for macromolecular structure determination. A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L WarrenActa Crystallogr D Biol Crystallogr19989757107Yes
304123711185.584.0642.0Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. A Fabiato, F FabiatoJ Physiol (Paris)1979533865Yes
304223711185.588.4444.2Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. H Esterbauer, K H CheesemanMethods Enzymol19902233308Yes
304323711185.5100.350.1The Warburg Effect: How Does it Benefit Cancer Cells? Maria V Liberti, Jason W LocasaleTrends Biochem Sci201626778478No
304411851185.052.1252.1Presynaptic regulation of the release of catecholamines. S Z LangerPharmacol Rev19806267618Yes
304511851185.030.0830.1Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. G BodenDiabetes19978971073No
304611851185.023.6823.7Up on the tightrope: natural killer cell activation and inhibition. Lewis L LanierNat Immunol200818425106No
304723691184.561.3630.7Verification of protein structures: patterns of nonbonded atomic interactions. C Colovos, T O YeatesProtein Sci19938401235Yes
304835531184.372.1724.1Cellular survival: a play in three Akts. S R Datta, A Brunet, M E GreenbergGenes Dev199910579998No
304923681184.049.2524.6Sequence logos: a new way to display consensus sequences. T D Schneider, R M StephensNucleic Acids Res19902172928Yes
305023681184.095.1647.6Rapid procedure for detection and isolation of large and small plasmids. C I Kado, S T LiuJ Bacteriol19817009583Yes
305111841184.036.336.3The somatic marker hypothesis and the possible functions of the prefrontal cortex. A R DamasioPhilos Trans R Soc Lond B Biol Sci19968941953No
305235511183.796.0732.0The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. G Blessed, B E Tomlinson, M RothBr J Psychiatry19685662937Yes
305323671183.561.0730.5Statistical tests of neutrality of mutations. Y X Fu, W H LiGenetics19938454210Yes
305411831183.026.2826.3The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. S J CollinsBlood19873311197No
305511831183.047.2847.3The anatomy of stages of change. A BanduraAm J Health Promot199710170438No
305611831183.030.0230.0Disorders of iron metabolism. N C AndrewsN Engl J Med199910607817No
305723661183.060.8730.4Humans integrate visual and haptic information in a statistically optimal fashion. Marc O Ernst, Martin S BanksNature200211807554Yes
305811831183.045.0345.0Glutathione synthesis. Shelly C LuBiochim Biophys Acta201322995213No
305923641182.066.8233.4Heterogeneous photocatalyst materials for water splitting. Akihiko Kudo, Yugo MisekiChem Soc Rev200919088977Yes
306011821182.054.7354.7Salience processing and insular cortical function and dysfunction. Lucina Q UddinNat Rev Neurosci201525406711No
306111811181.023.1123.1A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. Xuemei ChenScience200412893888Yes
306211811181.00.00.0Voluntary strength and fatigue. P A MertonJ Physiol195413152698Yes
306323621181.048.5224.3The mammalian unfolded protein response. Martin Schröder, Randal J KaufmanAnnu Rev Biochem200515952902No
306411811181.023.9423.9Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. Sean B CarrollCell200818614008Yes
306511811181.050.3550.4Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation. Karimollah Hajian-TilakiCaspian J Intern Med201324009950No
306623611180.568.3234.2The low-density lipoprotein pathway and its relation to atherosclerosis. J L Goldstein, M S BrownAnnu Rev Biochem1977197883No
306723611180.571.3335.7Plasmonics for improved photovoltaic devices. Harry A Atwater, Albert PolmanNat Mater201020168344Yes
306847201180.0132.4533.1AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang GuanNat Cell Biol201121258367Yes
306923591179.548.7724.4Toll-like receptors in the induction of the innate immune response. A Aderem, R J UlevitchNature200010963608No
307023591179.532.0916.0Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. R R Guillard, J H RytherCan J Microbiol196213902807Yes
307111791179.065.4965.5Nontuberculous mycobacteria and associated diseases. E WolinskyAm Rev Respir Dis1979369415No
307211791179.038.838.8Interleukin-1 and the pathogenesis of the acute-phase response. C A DinarelloN Engl J Med19846208485No
307311791179.045.1945.2Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. H V GelboinPhysiol Rev19807001511No
307411791179.028.2428.2A tension-based theory of morphogenesis and compact wiring in the central nervous system. D C Van EssenNature19979002514Yes
307511791179.032.4132.4The stress response to trauma and surgery. J P DesboroughBr J Anaesth200010927999No
307611791179.023.3623.4Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. Harold F DvorakJ Clin Oncol200212409337No
307711791179.023.5823.6Protein tyrosine phosphatases: from genes, to function, to disease. Nicholas K TonksNat Rev Mol Cell Biol200617057753No
307811791179.033.9634.0The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. R G PertweeBr J Pharmacol200817828291No
307923571178.565.0632.5Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. R G Phillips, J E LeDouxBehav Neurosci19921590953Yes
308011781178.045.8245.8Freezing of living cells: mechanisms and implications. P MazurAm J Physiol19846383068No
308111781178.025.4125.4The myofibroblast in wound healing and fibrocontractive diseases. G GabbianiJ Pathol200312845617No
308223551177.550.7925.4Lymphocyte homing and homeostasis. E C Butcher, L J PickerScience19968600538No
308358861177.2190.6438.1Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L WitztumN Engl J Med19892648148No
308411771177.072.9372.9Impingement lesions. C S NeerClin Orthop Relat Res19836825348Yes
308511771177.030.5830.6The neurobiology of stress: from serendipity to clinical relevance. B S McEwenBrain Res200011119695No
308623531176.5101.6950.8Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. P R Hunter, M A GastonJ Clin Microbiol19883069867Yes
308735291176.390.7630.3Methods in mammalian autophagy research. Noboru Mizushima, Tamotsu Yoshimori, Beth LevineCell201020144757Yes
308811761176.034.5134.5Analyzing the mosaic structure of genes. J M SmithJ Mol Evol19921556748No
308923521176.077.0238.5Physiological parameters in laboratory animals and humans. B Davies, T MorrisPharm Res19938378254No
309023521176.052.4326.2Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Jing Yang, Robert A WeinbergDev Cell200818539112No
309111761176.046.0446.0A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading. Cathy J PriceNeuroimage201222584224No
309247031175.8105.4726.4Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. J E Walker, M Saraste, M J Runswick, N J GayEMBO J19826329717Yes
309382281175.4162.4923.2Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P SpeedBiostatistics200312925520Yes
309411751175.037.8637.9Agents that increase the permeability of the outer membrane. M VaaraMicrobiol Rev19921406489No
309511751175.031.7431.7Presynaptic regulation of catecholamine release. S Z LangerBiochem Pharmacol19744617579No
309611751175.036.4136.4Peritonectomy procedures. P H SugarbakerAnn Surg19957826158Yes
309711751175.032.3332.3The induction of pain: an integrative review. M J MillanProg Neurobiol19999987804No
309811751175.024.124.1Apoptosis in neurodegenerative disorders. M P MattsonNat Rev Mol Cell Biol200011253364No
309911751175.028.3728.4Targeting DNA topoisomerase II in cancer chemotherapy. John L NitissNat Rev Cancer200919377506No
310046991174.8192.2648.1QUAST: quality assessment tool for genome assemblies. Alexey Gurevich, Vladislav Saveliev, Nikolay Vyahhi, Glenn TeslerBioinformatics201323422339Yes
3101187951174.7539.8333.7New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). E A Eisenhauer, P Therasse, J Bogaerts, L H Schwartz, D Sargent, R Ford, J Dancey, S Arbuck, S Gwyther, M Mooney, L Rubinstein, L Shankar, L Dodd, R Kaplan, D Lacombe, J VerweijEur J Cancer200919097774No
3102105671174.1273.830.4MolProbity: all-atom structure validation for macromolecular crystallography. Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C RichardsonActa Crystallogr D Biol Crystallogr201020057044Yes
310311741174.040.6440.6An approach for the treatment of penile carcinoma. R M CabanasCancer1977837331Yes
310411741174.038.4838.5Checklists for improving rigour in qualitative research: a case of the tail wagging the dog? R S BarbourBMJ200111337448No
310511741174.025.5125.5Simple model of spiking neurons. E M IzhikevichIEEE Trans Neural Netw200318244602Yes
310635211173.790.1430.0Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. C R Woese, O Kandler, M L WheelisProc Natl Acad Sci U S A19902112744Yes
310723471173.574.6637.3Quantitative determination of serum triglycerides by the use of enzymes. G Bucolo, H DavidClin Chem19734703655Yes
310823471173.573.2336.6Antiseptics and disinfectants: activity, action, and resistance. G McDonnell, A D RussellClin Microbiol Rev19999880479No
310911731173.026.0926.1Cadherins: a molecular family important in selective cell-cell adhesion. M TakeichiAnnu Rev Biochem19902197976No
311023461173.045.9123.0Multiple nuclear factors interact with the immunoglobulin enhancer sequences. R Sen, D BaltimoreCell19863091258Yes
311111731173.034.4834.5A human model of gastric carcinogenesis. P CorreaCancer Res19883288329No
311211731173.022.3222.3The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. Y YardenEur J Cancer200111597398No
311311731173.025.6525.6How neutrophils kill microbes. Anthony W SegalAnnu Rev Immunol200515771570No
311411731173.039.8639.9Volumetric modulated arc therapy: IMRT in a single gantry arc. Karl OttoMed Phys200818293586Yes
311546911172.8147.1836.8Epidemiology and causes of preterm birth. Robert L Goldenberg, Jennifer F Culhane, Jay D Iams, Roberto RomeroLancet200818177778No
311623451172.542.1821.1Hedgehog signaling in animal development: paradigms and principles. P W Ingham, A P McMahonGenes Dev200111731473No
311723441172.056.2128.1Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects. R P Rao, D H BallardNat Neurosci199910195184Yes
311811721172.038.038.0On the law of effect. R J HerrnsteinJ Exp Anal Behav197016811440Yes
311935151171.7162.5954.2Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. F Guillemin, C Bombardier, D BeatonJ Clin Epidemiol19938263569No
312058581171.6286.1157.2Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W StittJ Rheumatol19883068365Yes
312123431171.574.437.2Solubilization of membranes by detergents. A Helenius, K SimonsBiochim Biophys Acta19751091302No
312211711171.030.7530.8Pathogenesis of dengue: challenges to molecular biology. S B HalsteadScience19883277268No
312311711171.021.8621.9Shrinkage necrosis: a distinct mode of cellular death. J F KerrJ Pathol19714108566Yes
312411711171.027.8327.86-Hydroxy-dopamine induced degeneration of central monoamine neurons. U UngerstedtEur J Pharmacol19685718510Yes
312511711171.0106.15106.2The analysis of errors in orthodontic measurements. W J HoustonAm J Orthod19836573846Yes
312611711171.00.00.0A production of amino acids under possible primitive earth conditions. S L MillerScience195313056598Yes
312723421171.063.3331.7A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions. Yan Zhao, Donald G TruhlarJ Chem Phys200617129083Yes
312811711171.00.00.0Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. P B MedawarBr J Exp Pathol194818865105Yes
312935111170.370.4923.5Predicting coiled coils from protein sequences. A Lupas, M Van Dyke, J StockScience19912031185Yes
313023401170.036.8718.4Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. J D McGhee, P H von HippelJ Mol Biol19744416620Yes
313123401170.076.4838.2Efficacy of the Theory of Planned Behaviour: a meta-analytic review. C J Armitage, M ConnerBr J Soc Psychol200111795063Yes
313235101170.084.8528.3Astrocyte-endothelial interactions at the blood-brain barrier. N Joan Abbott, Lars Rönnbäck, Elisabeth HanssonNat Rev Neurosci200616371949No
313311701170.030.6330.6Bacteroides: the good, the bad, and the nitty-gritty. Hannah M WexlerClin Microbiol Rev200717934076No
313423391169.5201.39100.7Radiological demarcation of cemented sockets in total hip replacement. J G DeLee, J CharnleyClin Orthop Relat Res1976991504Yes
313523391169.561.4130.7The ubiquitin code. David Komander, Michael RapeAnnu Rev Biochem201222524316No
313611691169.022.1122.1Microarray data normalization and transformation. John QuackenbushNat Genet200212454644No
313711691169.00.00.0A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. J B BrownBiochem J195514389222Yes
313835071169.087.8229.3Use and abuse of HOMA modeling. Tara M Wallace, Jonathan C Levy, David R MatthewsDiabetes Care200415161807No
313923361168.052.4326.2Adaptive protein evolution at the Adh locus in Drosophila. J H McDonald, M KreitmanNature19911904993Yes
314011681168.042.0742.1The case for motivated reasoning. Z KundaPsychol Bull19902270237No
314135041168.078.7826.3Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. A L Shapiro, E Viñuela, J V MaizelBiochem Biophys Res Commun19674861258Yes
314211681168.035.7435.7Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. M E BoutonPsychol Bull19938346330No
314311681168.034.8434.8Low-molecular-weight heparins. J I WeitzN Engl J Med19979278467No
314411681168.00.00.0A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. M G BuonocoreJ Dent Res195513271655Yes
314535031167.7116.8939.0Hepatocellular carcinoma. Alejandro Forner, Josep M Llovet, Jordi BruixLancet201222353262No
314623351167.570.9235.5Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. S Geman, D GemanIEEE Trans Pattern Anal Mach Intell198422499653Yes
314735021167.3119.3539.8The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting. C Kirschbaum, K M Pirke, D H HellhammerNeuropsychobiology19938255414Yes
314846691167.2124.0231.0Organometal halide perovskites as visible-light sensitizers for photovoltaic cells. Akihiro Kojima, Kenjiro Teshima, Yasuo Shirai, Tsutomu MiyasakaJ Am Chem Soc200919366264Yes
314911671167.031.7931.8Pharmacology of cannabinoid CB1 and CB2 receptors. R G PertweePharmacol Ther19979336020No
315011671167.030.6930.7Epidemiology of women and depression. Ronald C KesslerJ Affect Disord200312646294Yes
315111671167.035.4535.5Platelet-rich plasma: evidence to support its use. Robert E MarxJ Oral Maxillofac Surg200415085519No
315211671167.028.0728.1Context and behavioral processes in extinction. Mark E BoutonLearn Mem200415466298No
315311671167.022.8122.8Telomeres and human disease: ageing, cancer and beyond. Maria A BlascoNat Rev Genet200516136653No
315446671166.8108.4627.1Base-calling of automated sequencer traces using phred. I. Accuracy assessment. B Ewing, L Hillier, M C Wendl, P GreenGenome Res19989521921Yes
3155116641166.4423.9442.4The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gøtzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David MoherBMJ200919622552No
315611661166.035.6335.6MOPAC: a semiempirical molecular orbital program. J J StewartJ Comput Aided Mol Des19902197373No
315711661166.023.8623.9Biogenic amines and the states of sleep. M JouvetScience19694303225No
315811661166.031.2231.2Core affect and the psychological construction of emotion. James A RussellPsychol Rev200312529060No
315911651165.022.1222.1Contingent genetic regulatory events in T lymphocyte activation. G R CrabtreeScience19892783497Yes
316011651165.011.5411.5Pathologic anatomy of the pancreas in juvenile diabetes mellitus. W GeptsDiabetes19655318831Yes
316123301165.049.1924.6Functions of lipid rafts in biological membranes. D A Brown, E LondonAnnu Rev Cell Dev Biol19989891780No
316211651165.025.7325.7Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. H J DargieLancet200111356434Yes
316311651165.024.1624.2Microsatellites: simple sequences with complex evolution. Hans EllegrenNat Rev Genet200415153996No
316411651165.031.3731.4Production and scavenging of reactive oxygen species in chloroplasts and their functions. Kozi AsadaPlant Physiol200616760493Yes
316511651165.043.4843.5Energy metabolism in the liver. Liangyou RuiCompr Physiol201424692138No
316646581164.589.5822.4Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. L Alexopoulou, A C Holt, R Medzhitov, R A FlavellNature200111607032Yes
316711641164.036.7136.7Molecular biology of steroid hormone synthesis. W L MillerEndocr Rev19883061784No
316811641164.041.0441.0Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. M A LempCLAO J19958565190No
316911641164.044.8544.9The biogenesis and emerging roles of circular RNAs. Ling-Ling ChenNat Rev Mol Cell Biol201626908011Yes
317069831163.8237.4439.6The occurrence of sleep-disordered breathing among middle-aged adults. T Young, M Palta, J Dempsey, J Skatrud, S Weber, S BadrN Engl J Med19938464434Yes
317123271163.595.6847.8Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. Ian Janssen, Allana G LeblancInt J Behav Nutr Phys Act201020459784Yes
317234891163.0139.2646.4Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. A DeLean, P J Munson, D RodbardAm J Physiol1978686171Yes
317334891163.076.9725.7Hepatocellular carcinoma. Josep M Llovet, Andrew Burroughs, Jordi BruixLancet200314667750No
317446501162.5131.4932.9Biological identifications through DNA barcodes. Paul D N Hebert, Alina Cywinska, Shelley L Ball, Jeremy R deWaardProc Biol Sci200312614582Yes
317511621162.034.2534.2Determinants of tumor blood flow: a review. R K JainCancer Res19883282647No
317611621162.034.7634.8Effect of anoxia on ion distribution in the brain. A J HansenPhysiol Rev19853880896No
317711621162.051.9351.9Preliminary Trial Of Carisoprodol In Multiple Sclerosis. B AshworthPractitioner196414143329Yes
317811621162.023.423.4Liver regeneration: from myth to mechanism. Rebecca TaubNat Rev Mol Cell Biol200415459664No
317923241162.071.3435.7bold: The Barcode of Life Data System (http://www.barcodinglife.org). Sujeevan Ratnasingham, Paul D N HebertMol Ecol Notes200718784790Yes
318034851161.773.0624.4Computer visualization of three-dimensional image data using IMOD. J R Kremer, D N Mastronarde, J R McIntoshJ Struct Biol19968742726Yes
3181104541161.6270.030.0Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Cole Trapnell, Brian A Williams, Geo Pertea, Ali Mortazavi, Gordon Kwan, Marijke J van Baren, Steven L Salzberg, Barbara J Wold, Lior PachterNat Biotechnol201020436464Yes
318211601160.022.0822.1RNA metabolism in the HeLa cell nucleus. S PenmanJ Mol Biol19665961144Yes
318311601160.026.6626.7Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. William C AirdCirc Res200717272818No
318469601160.0198.233.0Genome engineering using the CRISPR-Cas9 system. F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng ZhangNat Protoc201324157548Yes
318523191159.557.0328.5Plasminogen: purification from human plasma by affinity chromatography. D G Deutsch, E T MertzScience19705475635Yes
318611591159.026.7526.8Neurons with graded response have collective computational properties like those of two-state neurons. J J HopfieldProc Natl Acad Sci U S A19846587342Yes
318711591159.035.9836.0Strategies of antioxidant defense. H SiesEur J Biochem19937688300No
318811591159.039.1539.1beta-Lactamases in laboratory and clinical resistance. D M LivermoreClin Microbiol Rev19958665470No
318934761158.784.7828.3High resolution two-dimensional electrophoresis of basic as well as acidic proteins. P Z O'Farrell, H M Goodman, P H O'FarrellCell197723215Yes
319023171158.579.4139.7The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. G P Chrousos, P W GoldJAMA19921538563No
319123171158.572.8536.4The reward circuit: linking primate anatomy and human imaging. Suzanne N Haber, Brian KnutsonNeuropsychopharmacology201019812543No
319211581158.033.1133.1What is synergy? M C BerenbaumPharmacol Rev19892692037No
319323161158.067.6433.8A rating scale for extrapyramidal side effects. G M Simpson, J W AngusActa Psychiatr Scand Suppl19704917967Yes
319411581158.026.8826.9Amyloid, the presenilins and Alzheimer's disease. J HardyTrends Neurosci19979106355No
319511581158.038.3338.3Enhancing the quality and credibility of qualitative analysis. M Q PattonHealth Serv Res199910591279No
319611581158.00.00.0Observations on the isolated phrenic nerve diaphragm preparation of the rat. E BulbringBr J Pharmacol Chemother194620999334Yes
319734741158.0219.4573.1Production, use, and fate of all plastics ever made. Roland Geyer, Jenna R Jambeck, Kara Lavender LawSci Adv201728776036Yes
319823151157.577.0538.5Pharmaceuticals and personal care products in the environment: agents of subtle change? C G Daughton, T A TernesEnviron Health Perspect199910592150No
319911571157.017.4217.4The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. R E Hope-SimpsonProc R Soc Med196514267505Yes
320011571157.021.3421.3Biological robustness. Hiroaki KitanoNat Rev Genet200415520792No
320123141157.049.5224.8Defining the role of mTOR in cancer. David A Guertin, David M SabatiniCancer Cell200717613433No
320223141157.050.225.1Blinded by the Light: The Growing Complexity of p53. Karen H Vousden, Carol PrivesCell200919410540No
320311571157.055.7455.7When to use the Bonferroni correction. Richard A ArmstrongOphthalmic Physiol Opt201424697967No
320434691156.3146.8448.9Measurement of health status. Ascertaining the minimal clinically important difference. R Jaeschke, J Singer, G H GuyattControl Clin Trials19892691207Yes
320523121156.053.8326.9Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Josep M Llovet, Jordi BruixHepatology200312540794No
320623121156.053.4926.7Regulation of wound healing by growth factors and cytokines. Sabine Werner, Richard GrosePhysiol Rev200312843410No
320711561156.025.2725.3G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. Jeffery T DavisAngew Chem Int Ed Engl200414755695No
320857771155.4108.2221.6The protein kinase complement of the human genome. G Manning, D B Whyte, R Martinez, T Hunter, S SudarsanamScience200212471243No
320923101155.047.4623.7Learning the parts of objects by non-negative matrix factorization. D D Lee, H S SeungNature199910548103Yes
321034651155.091.530.5Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Dunyaporn Trachootham, Jerome Alexandre, Peng HuangNat Rev Drug Discov200919478820No
321157741154.8213.5942.7DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates. O Folmer, M Black, W Hoeh, R Lutz, R VrijenhoekMol Mar Biol Biotechnol19947881515Yes
321223091154.566.733.4Excitatory amino acids as a final common pathway for neurologic disorders. S A Lipton, P A RosenbergN Engl J Med19947905600No
321311541154.012.9112.9Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J AltmanJ Comp Neurol19695361244Yes
321411541154.050.5650.6Coping theory and research: past, present, and future. R S LazarusPsychosom Med19938346332No
321511541154.022.0722.1Mechanisms and consequences of activation of protein kinase B/Akt. J DownwardCurr Opin Cell Biol19989561851No
321623081154.043.8621.9NF-kappaB at the crossroads of life and death. Michael Karin, Anning LinNat Immunol200211875461No
321711541154.038.3838.4Mediators and mechanisms of change in psychotherapy research. Alan E KazdinAnnu Rev Clin Psychol200717716046No
321823071153.564.4432.2Growth of a rat neuroblastoma cell line in serum-free supplemented medium. J E Bottenstein, G H SatoProc Natl Acad Sci U S A1979284369Yes
321923071153.546.4623.2A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. N C Andrews, D V FallerNucleic Acids Res19912041787Yes
322023071153.583.5141.8Severe sepsis and septic shock. Derek C Angus, Tom van der PollN Engl J Med201323984731No
322123061153.070.8435.4Role of oxidized low density lipoprotein in atherogenesis. J L Witztum, D SteinbergJ Clin Invest19911752940No
322211531153.024.2524.2Stem cells in the central nervous system. R McKayScience19979082987No
322311531153.00.00.0A sensitive method for the assay of 5-hydroxytryptamine. J R VaneBr J Pharmacol Chemother195713460242Yes
322423061153.053.9927.0Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Julie A Law, Steven E JacobsenNat Rev Genet201020142834No
322534571152.3103.7134.6SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building. Manolo Gouy, Stéphane Guindon, Olivier GascuelMol Biol Evol201019854763Yes
322611521152.027.3127.3Selective coronary arteriography. I. A percutaneous transfemoral technic. M P JudkinsRadiology19676048074Yes
322734561152.0106.5535.5Evaluating the public health impact of health promotion interventions: the RE-AIM framework. R E Glasgow, T M Vogt, S M BolesAm J Public Health199910474547No
322823041152.038.6519.3Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. R W Butcher, E W SutherlandJ Biol Chem196213875173Yes
322911521152.052.352.3The problem with the phrase women and minorities: intersectionality-an important theoretical framework for public health. Lisa BowlegAm J Public Health201222594719Yes
323023031151.566.5133.3Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. P Brugada, J BrugadaJ Am Coll Cardiol19921309182Yes
323123031151.548.0324.0Protein aggregation and neurodegenerative disease. Christopher A Ross, Michelle A PoirierNat Med200415272267No
323223031151.590.845.4Kraken: ultrafast metagenomic sequence classification using exact alignments. Derrick E Wood, Steven L SalzbergGenome Biol201424580807Yes
323311511151.045.7645.8Radioimmunological determination of human C-peptide in serum. L G HedingDiabetologia19751239396Yes
323457551151.0163.5132.7Quantitative assessment of tactile allodynia in the rat paw. S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L YakshJ Neurosci Methods19947990513Yes
323523011150.551.6125.8Shape-controlled synthesis of gold and silver nanoparticles. Yugang Sun, Younan XiaScience200212481134Yes
3236115021150.2290.0329.0Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. M Dominici, K Le Blanc, I Mueller, I Slaper-Cortenbach, Fc Marini, Ds Krause, Rj Deans, A Keating, Dj Prockop, Em HorwitzCytotherapy200616923606Yes
323711501150.036.0936.1Relations between the statistics of natural images and the response properties of cortical cells. D J FieldJ Opt Soc Am A19873430225Yes
323811501150.029.4929.5The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. R A JainBiomaterials200011055295No
323911501150.024.7624.8Serine protease mechanism and specificity. Lizbeth HedstromChem Rev200212475199No
324011501150.035.2235.2A practical solution to the pervasive problems of p values. Eric-Jan WagenmakersPsychon Bull Rev200718087943Yes
324122991149.567.3533.7Nitric oxide synthases in mammals. R G Knowles, S MoncadaBiochem J19947510950No
324211491149.014.6514.7Central dogma of molecular biology. F CrickNature19704913914No
324311491149.031.3631.4Leishmaniasis. B L HerwaldtLancet199910513726No
324411491149.024.124.1Epstein-Barr virus infection. J I CohenN Engl J Med200010944566No
324522981149.043.5221.8Rho GTPases: biochemistry and biology. Aron B Jaffe, Alan HallAnnu Rev Cell Dev Biol200516212495No
324622981149.061.3730.7BODIPY dyes and their derivatives: syntheses and spectroscopic properties. Aurore Loudet, Kevin BurgessChem Rev200717924696Yes
324711481148.033.033.0Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. D B ClewellJ Bacteriol19724336693Yes
324811481148.019.7719.8Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. M S WoldAnnu Rev Biochem19979242902No
324922961148.050.6525.3Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. N Sreerama, R W WoodyAnal Biochem200011112271Yes
325011481148.027.7927.8Mode of action of membrane active antimicrobial peptides. Yechiel ShaiBiopolymers200212491537No
325111481148.037.6537.6Starting at the beginning: an introduction to coefficient alpha and internal consistency. David L StreinerJ Pers Assess200312584072Yes
325211481148.00.00.0Fertilizing capacity of spermatozoa deposited into the fallopian tubes. M C ChangNature195114882325Yes
325311481148.024.1924.2The advantages and disadvantages of being polyploid. Luca ComaiNat Rev Genet200516304599No
325411481148.032.9132.9Rethinking schizophrenia. Thomas R InselNature201021068826No
325511481148.027.9628.0Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. Christof M NiemeyerAngew Chem Int Ed Engl200129712109No
325634431147.780.6526.9Prediction of total genetic value using genome-wide dense marker maps. T H Meuwissen, B J Hayes, M E GoddardGenetics200111290733Yes
325711471147.028.4428.4The epidemiologic transition. A theory of the epidemiology of population change. A R OmranMilbank Mem Fund Q19715155251Yes
325811471147.031.9431.9DNA topoisomerases. M GellertAnnu Rev Biochem19816267993No
325922941147.093.5746.8Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Ulrich M Zanger, Matthias SchwabPharmacol Ther201323333322No
326011461146.031.131.1Diseases of the mitochondrial DNA. D C WallaceAnnu Rev Biochem19921497308No
326111461146.022.3922.4Inferences, questions and possibilities in Toll-like receptor signalling. Bruce BeutlerNature200415241424No
326211461146.022.1122.1Regulation of cadherin-mediated adhesion in morphogenesis. Barry M GumbinerNat Rev Mol Cell Biol200516025097No
326311461146.024.1224.1Version 1.2 of the Crystallography and NMR system. Axel T BrungerNat Protoc200718007608Yes
326445831145.8110.9727.7Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. H Nielsen, J Engelbrecht, S Brunak, G von HeijneProtein Eng19979051728Yes
326534371145.7145.6648.6Principles of nanoparticle design for overcoming biological barriers to drug delivery. Elvin Blanco, Haifa Shen, Mauro FerrariNat Biotechnol201526348965Yes
326634361145.391.7730.6Matrix metalloproteinases: regulators of the tumor microenvironment. Kai Kessenbrock, Vicki Plaks, Zena WerbCell201020371345No
326711451145.039.1439.1Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases. K TamuraMol Biol Evol19921630306Yes
326811451145.059.5659.6A "rationalized" arcsine transform. G A StudebakerJ Speech Hear Res19854046587Yes
326911451145.033.0133.0An improved fluorometric assay for DNA. R T HinegardnerAnal Biochem19715544593Yes
327022901145.050.325.1Esophageal cancer. Peter C Enzinger, Robert J MayerN Engl J Med200314657432No
327111451145.031.131.1Stronger Brønsted acids. Takahiko AkiyamaChem Rev200717983247Yes
327211451145.050.5450.5How neuroinflammation contributes to neurodegeneration. Richard M RansohoffScience201627540165No
327368671144.5198.6533.1The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis. A Miyake, N P Friedman, M J Emerson, A H Witzki, A Howerter, T D WagerCogn Psychol200010945922Yes
327434331144.395.6531.9Regulation of cancer cell metabolism. Rob A Cairns, Isaac S Harris, Tak W MakNat Rev Cancer201121258394No
327534321144.0107.9736.0Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. G M Wahl, M Stern, G R StarkProc Natl Acad Sci U S A1979291033Yes
327622881144.068.3334.2Multiple significance tests: the Bonferroni method. J M Bland, D G AltmanBMJ19957833759Yes
327711441144.00.00.0The powerful placebo. H K BeecherJ Am Med Assoc195513271123Yes
327811441144.07.167.2A New Serum Type System In Man--The Lp System. K BergActa Pathol Microbiol Scand196314064818Yes
327922881144.067.9734.0Type 2 diabetes as an inflammatory disease. Marc Y Donath, Steven E ShoelsonNat Rev Immunol201121233852No
328022871143.567.2233.6The capacity of visual working memory for features and conjunctions. S J Luck, E K VogelNature19979384378Yes
328111431143.048.1848.2A spreading-activation theory of retrieval in sentence production. G S DellPsychol Rev19863749399Yes
328211431143.00.00.0The perceptron: a probabilistic model for information storage and organization in the brain. F RosenblattPsychol Rev195813602029Yes
328311431143.016.5916.6Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. R J PenningtonBiochem J196113734134Yes
328411431143.022.722.7Diffusion-in-gel methods for immunological analysis. II. O OuchterlonyProg Allergy196214482809Yes
328534291143.087.8829.3The widespread regulation of microRNA biogenesis, function and decay. Jacek Krol, Inga Loedige, Witold FilipowiczNat Rev Genet201020661255No
328611431143.048.7848.8The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review. Erik G WillcuttNeurotherapeutics201222976615No
328722851142.547.0223.5Plant pathogens and integrated defence responses to infection. J L Dangl, J D JonesNature200111459065No
328811421142.041.941.9Omega-3 fatty acids in health and disease and in growth and development. A P SimopoulosAm J Clin Nutr19911908631No
328911421142.028.7128.7Two-stage model of memory trace formation: a role for "noisy" brain states. G BuzsákiNeuroscience19892687720No
329011421142.040.5440.5Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. W A CatterallAnnu Rev Pharmacol Toxicol19806247957No
329111421142.040.9941.0Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls? Fay B HorakAge Ageing200616926210No
329211411141.033.3233.3Reducing children's television viewing to prevent obesity: a randomized controlled trial. T N RobinsonJAMA199910546696Yes
329311411141.025.6225.6Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. Michael J SandersonMol Biol Evol200211752195Yes
329411411141.035.5335.5Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Ronald A HitesEnviron Sci Technol200414998004Yes
329522811140.548.0824.0Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Nahum Sonenberg, Alan G HinnebuschCell200919239892No
329622801140.060.4130.2Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. M J Casadaban, S N CohenJ Mol Biol19806997493Yes
329711401140.031.2831.3Riddle of biofilm resistance. K LewisAntimicrob Agents Chemother200111257008No
329811401140.021.5321.5The power and the promise of DNA methylation markers. Peter W LairdNat Rev Cancer200312671664No
329922791139.544.4122.2Homeobox genes and axial patterning. W McGinnis, R KrumlaufCell19921346368No
330022791139.50.00.0Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. H H Ussing, K ZerahnActa Physiol Scand195114868510Yes
330122791139.553.8826.9Endometriosis. Linda C Giudice, Lee C KaoLancet200415541453No
330211391139.042.5642.6Molecular aspects of ligand binding to serum albumin. U Kragh-HansenPharmacol Rev19817027277No
330311391139.021.1321.1Regulation of phosphoinositide-specific phospholipase C. S G RheeAnnu Rev Biochem200111395409No
330422781139.066.933.5Health effects of fine particulate air pollution: lines that connect. C Arden Pope, Douglas W DockeryJ Air Waste Manag Assoc200616805397No
330511391139.025.3825.4Next-generation DNA sequencing methods. Elaine R MardisAnnu Rev Genomics Hum Genet200818576944No
330645561139.0171.9243.0Near-optimal probabilistic RNA-seq quantification. Nicolas L Bray, Harold Pimentel, Páll Melsted, Lior PachterNat Biotechnol201627043002Yes
330711391139.057.3657.4The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease. Costantino IadecolaNeuron201728957666No
330811381138.022.1622.2Structure of chromatin. R D KornbergAnnu Rev Biochem1977332067No
330911381138.029.8929.9A theory of magnitude: common cortical metrics of time, space and quantity. Vincent WalshTrends Cogn Sci200314585444Yes
331011381138.030.8230.8A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Ron HardmanEnviron Health Perspect200616451849No
331122761138.050.7325.4microRNA functions. Natascha Bushati, Stephen M CohenAnnu Rev Cell Dev Biol200717506695No
331222751137.5108.4254.2Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. S F Dworkin, L LeRescheJ Craniomandib Disord19921298767No
331334121137.396.5132.2Cytochemical identification of monocytes and granulocytes. L T Yam, C Y Li, W H CrosbyAm J Clin Pathol19715549896Yes
331411371137.050.1150.1Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. S Z LangerBr J Pharmacol197720190No
331511371137.033.033.0Animal mitochondrial DNA: structure and evolution. D R WolstenholmeInt Rev Cytol19921452431No
331611371137.033.7533.8Unstable angina. A classification. E BraunwaldCirculation19892752565Yes
331722741137.088.6944.3A simple method to assess exercise behavior in the community. G Godin, R J ShephardCan J Appl Sport Sci19854053261Yes
331811371137.020.1820.2Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Eric C LaiNat Genet200211896390Yes
331911371137.021.9221.9VEGF and the quest for tumour angiogenesis factors. Napoleone FerraraNat Rev Cancer200212360282No
332011371137.050.5550.5Canadian Diabetes Association 2013 clinical practice guidelines for the prevention and management of diabetes in Canada. Introduction. Alice Y Y ChengCan J Diabetes201324070926No
332122731136.546.5623.3Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. G A Gonzalez, M R MontminyCell19892573431Yes
332211361136.038.738.7Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. A R MidgleyEndocrinology19665950482Yes
332379501135.7277.3739.6Metagenomic biomarker discovery and explanation. Nicola Segata, Jacques Izard, Levi Waldron, Dirk Gevers, Larisa Miropolsky, Wendy S Garrett, Curtis HuttenhowerGenome Biol201121702898Yes
332411351135.025.9325.9Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units. C M VenkatachalamBiopolymers19685685102Yes
332534021134.096.9132.3A sensitive and reliable locomotor rating scale for open field testing in rats. D M Basso, M S Beattie, J C BresnahanJ Neurotrauma19957783230Yes
332611341134.030.7730.8Venous thrombosis: a multicausal disease. F R RosendaalLancet199910209995No
332711341134.026.6426.6Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Richard C ScarpullaPhysiol Rev200818391175No
332834021134.0106.5435.5Development and applications of CRISPR-Cas9 for genome engineering. Patrick D Hsu, Eric S Lander, Feng ZhangCell201424906146No
332922671133.521.310.7A Generalization Of The Retention Index System Including Linear Temperature Programmed Gas-Liquid Partition Chromatography. H Vandendool, P D KratzJ Chromatogr196314062605Yes
333011331133.022.1322.1Regulation of transcription by MAP kinase cascades. R TreismanCurr Opin Cell Biol19968791420No
333111331133.026.1626.2Allelic discrimination using fluorogenic probes and the 5' nuclease assay. K J LivakGenet Anal199910084106Yes
333211331133.020.3220.3The development of neural stem cells. S TempleNature200111689956No
333367971132.8152.3825.4Principal components analysis corrects for stratification in genome-wide association studies. Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David ReichNat Genet200616862161Yes
333422651132.577.4938.7A simple index of Crohn's-disease activity. R F Harvey, J M BradshawLancet19806102236Yes
333511321132.056.3456.3The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. G A IlizarovClin Orthop Relat Res19892910611Yes
333622631131.553.3926.7ZINC--a free database of commercially available compounds for virtual screening. John J Irwin, Brian K ShoichetJ Chem Inf Model200515667143Yes
333722621131.044.4922.2Tumour-cell invasion and migration: diversity and escape mechanisms. Peter Friedl, Katarina WolfNat Rev Cancer200312724734No
333811311131.00.00.0pA, a new scale for the measurement of drug antagonism. H O SchildBr J Pharmacol Chemother194720258355Yes
333911311131.056.8756.9Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review. Dariush MozaffarianCirculation201626746178No
334011301130.028.2628.3Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. I J FidlerCancer Res19901698118Yes
334111301130.032.0432.0Cholesterol and the cell membrane. P L YeagleBiochim Biophys Acta19853904832No
334233901130.072.3624.1A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. M Serrano, G J Hannon, D BeachNature19938259215Yes
334322601130.058.4729.2Protein oxidation in aging, disease, and oxidative stress. B S Berlett, E R StadtmanJ Biol Chem19979252331No
334411301130.026.4626.5Aptamers: an emerging class of molecules that rival antibodies in diagnostics. S D JayasenaClin Chem199910471678No
334522601130.049.024.5Deep tissue two-photon microscopy. Fritjof Helmchen, Winfried DenkNat Methods200516299478No
334611301130.042.9643.0Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. L SjöströmJ Intern Med201323163728No
334722591129.542.3621.2The druggable genome. Andrew L Hopkins, Colin R GroomNat Rev Drug Discov200212209152No
334822581129.032.8916.4Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. L M Siegel, K J MontyBiochim Biophys Acta19665329026Yes
334911291129.023.1223.1Understanding the odd science of aging. Thomas B L KirkwoodCell200515734677No
335011291129.027.3927.4Correlates of protection induced by vaccination. Stanley A PlotkinClin Vaccine Immunol201020463105No
335133861128.790.6230.2Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. R Schreck, P Rieber, P A BaeuerleEMBO J19912065663Yes
335211281128.023.6523.6Evolution of ageing. T B KirkwoodNature1977593350Yes
335311281128.038.2638.3Selective attention and the organization of visual information. J DuncanJ Exp Psychol Gen19846240521Yes
335411281128.030.2230.2The chromosomal basis of human neoplasia. J J YunisScience19836336310Yes
335511281128.042.142.1Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. J T DaugirdasJ Am Soc Nephrol19938305648Yes
335611281128.036.036.0Predictors of postpartum depression: an update. C T BeckNurs Res200111570712Yes
335711281128.023.8823.9Molecular imaging of cancer with positron emission tomography. Sanjiv Sam GambhirNat Rev Cancer200212209157No
335811281128.030.2130.2Disseminating innovations in health care. Donald M BerwickJAMA200312697800Yes
335933831127.790.1330.0Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Robert G Hart, Lesly A Pearce, Maria I AguilarAnn Intern Med200717577005Yes
336011271127.042.642.6On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. D CollenThromb Haemost19806450468No
336111271127.023.9523.9Fluorescence spectroscopy of single biomolecules. S WeissScience199910073925No
336211271127.00.00.0A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. R D HotchkissArch Biochem194818921848Yes
336311271127.030.5430.5AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. D Grahame HardieGenes Dev201121937710No
336411271127.046.0846.1The biology and function of exosomes in cancer. Raghu KalluriJ Clin Invest201627035812No
336522531126.568.7434.4Self-management education: history, definition, outcomes, and mechanisms. Kate R Lorig, Halsted HolmanAnn Behav Med200312867348No
336622531126.554.1527.1ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Benoît D'Autréaux, Michel B ToledanoNat Rev Mol Cell Biol200717848967No
336722531126.599.1449.6The lifelong effects of early childhood adversity and toxic stress. Jack P Shonkoff, Andrew S GarnerPediatrics201222201156Yes
336811261126.023.6323.6Mutator phenotype may be required for multistage carcinogenesis. L A LoebCancer Res19912039987No
336911261126.027.9127.9Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. M M WeiserJ Biol Chem19734698230Yes
337011261126.026.6226.6Mechanisms of lipid peroxide formation in animal tissues. E D WillsBiochem J19665964963Yes
337111261126.033.1333.1Cell surface interactions with extracellular materials. K M YamadaAnnu Rev Biochem19836351729No
337222511125.560.3930.2Mechanisms of biofilm resistance to antimicrobial agents. T F Mah, G A O'TooleTrends Microbiol200111166241No
337322501125.075.6437.8Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. A E Czeizel, I DudásN Engl J Med19921307234Yes
337411251125.024.9625.0Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. M KozakNucleic Acids Res19817301588Yes
337511251125.00.00.0The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. J VagueAm J Clin Nutr195613282851Yes
337622501125.049.0624.5Regeneration beyond the glial scar. Jerry Silver, Jared H MillerNat Rev Neurosci200414735117No
337722501125.053.9427.0Toxoplasmosis. J G Montoya, O LiesenfeldLancet200415194258No
337822501125.068.6934.3Mitochondrial fission, fusion, and stress. Richard J Youle, Alexander M van der BliekScience201222936770No
337922491124.551.0725.5Next-generation DNA sequencing. Jay Shendure, Hanlee JiNat Biotechnol200818846087Yes
338011241124.023.0423.0Differentiation and proliferation of hematopoietic stem cells. M OgawaBlood19938499622No
338156201124.0111.722.3Electrostatics of nanosystems: application to microtubules and the ribosome. N A Baker, D Sept, S Joseph, M J Holst, J A McCammonProc Natl Acad Sci U S A200111517324Yes
338211241124.00.00.0Knee joint changes after meniscectomy. T J FairbankJ Bone Joint Surg Br194818894618Yes
338311241124.031.7431.7Neurophysiological and computational principles of cortical rhythms in cognition. Xiao-Jing WangPhysiol Rev201020664082No
338422481124.051.1625.6The Polycomb complex PRC2 and its mark in life. Raphaël Margueron, Danny ReinbergNature201121248841No
338522471123.559.129.6Oxidative stress, caloric restriction, and aging. R S Sohal, R WeindruchScience19968658196No
338622471123.554.9527.5The protective effects of estrogen on the cardiovascular system. M E Mendelsohn, R H KarasN Engl J Med199910362825No
3387112351123.5442.944.3MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space. Fredrik Ronquist, Maxim Teslenko, Paul van der Mark, Daniel L Ayres, Aaron Darling, Sebastian Höhna, Bret Larget, Liang Liu, Marc A Suchard, John P HuelsenbeckSyst Biol201222357727Yes
338811231123.067.4467.4Cytoprotection by prostaglandins. A RobertGastroenterology197938173Yes
338922461123.044.6222.3Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. R J Britten, D E KohneScience19684874239Yes
339011231123.014.7514.8The nature and significance of platelet products in human plasma. P WolfBr J Haematol19676025241Yes
339111231123.023.4423.4ALSCRIPT: a tool to format multiple sequence alignments. G J BartonProtein Eng19938433969Yes
339211231123.025.4725.5The columnar organization of the neocortex. V B MountcastleBrain19979153131No
339311231123.00.00.0Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. A B StavitskyJ Immunol195413163409Yes
339411231123.017.2317.2Inherited Antithrombin Deficiency Causing Thrombophilia. O EgebergThromb Diath Haemorrh196514347873Yes
339511231123.046.0146.0The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. Natalie A de MortonAust J Physiother200919463084Yes
339622451122.564.7132.4Strategies in the design of nanoparticles for therapeutic applications. Robby A Petros, Joseph M DeSimoneNat Rev Drug Discov201020616808No
339711221122.028.1128.1Sex-hormone-binding globulin. D C AndersonClin Endocrinol (Oxf)19744134992No
339811221122.020.5420.5DNA methylation in cancer: too much, but also too little. Melanie EhrlichOncogene200212154403No
339911221122.024.5924.6r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock. Michael J SandersonBioinformatics200312538260Yes
340011221122.029.629.6Time is brain--quantified. Jeffrey L SaverStroke200616339467Yes
340111221122.064.3864.4Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV. Douglas A DrossmanGastroenterology201627144617Yes
340244851121.2103.1425.8SCOP: a structural classification of proteins database for the investigation of sequences and structures. A G Murzin, S E Brenner, T Hubbard, C ChothiaJ Mol Biol19957723011Yes
340311211121.054.3354.3Self-discrepancy: a theory relating self and affect. E T HigginsPsychol Rev19873615707Yes
340444841121.0145.4736.4The cholinergic hypothesis of geriatric memory dysfunction. R T Bartus, R L Dean, B Beer, A S LippaScience19827046051No
340511211121.022.0622.1Cytokine receptor signalling. J N IhleNature19957566171No
340611211121.00.00.0Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins. R D OwenScience194517755278Yes
340722421121.072.7836.4Long non-coding RNAs: new players in cell differentiation and development. Alessandro Fatica, Irene BozzoniNat Rev Genet201424296535No
340811211121.042.7942.8Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. George S BloomJAMA Neurol201424493463No
340944831120.8110.0727.5Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod MenonProc Natl Acad Sci U S A200312506194Yes
341011201120.034.4534.5Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J E OesterlingJ Urol19911707989No
341122401120.089.9145.0Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococcus species. R Vilgalys, M HesterJ Bacteriol19902376561Yes
341222401120.088.3744.2Statistical methods for assessing measurement error (reliability) in variables relevant to sports medicine. G Atkinson, A M NevillSports Med19989820922No
341367201120.0223.9937.3The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gøtzsche, Jan P VandenbrouckeJ Clin Epidemiol200818313558Yes
341422401120.050.025.0Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. William G Kaelin, Peter J RatcliffeMol Cell200818498744No
341522391119.574.5737.3Microdroplet Assay Of Human Serum Cytotoxins. P I Terasaki, J D McclellandNature196414248725Yes
341611191119.023.5923.6Molecular cloning and expression of glycogen synthase kinase-3/factor A. J R WoodgettEMBO J19902164470Yes
341722381119.048.8624.4Prediction of protein secondary structure at better than 70% accuracy. B Rost, C SanderJ Mol Biol19938345525Yes
341811191119.027.6227.6Formation and function of the myofibroblast during tissue repair. Boris HinzJ Invest Dermatol200717299435No
3419111891118.9254.9725.5Scalable molecular dynamics with NAMD. James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kalé, Klaus SchultenJ Comput Chem200516222654Yes
342022361118.059.0129.5Fitness effects on the cognitive function of older adults: a meta-analytic study. Stanley Colcombe, Arthur F KramerPsychol Sci200312661673Yes
342122361118.051.0425.5Modes of resistance to anti-angiogenic therapy. Gabriele Bergers, Douglas HanahanNat Rev Cancer200818650835No
342244701117.5107.9127.0C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. P M Ridker, C H Hennekens, J E Buring, N RifaiN Engl J Med200010733371Yes
342311171117.051.451.4Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder. M RutterBr J Psychiatry19853830321Yes
342411171117.032.532.5Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. P S ToftsJ Magn Reson Imaging19979039598No
342511171117.00.00.0A cytoarchitectonic atlas of the spinal cord in the cat. B RexedJ Comp Neurol195413163236Yes
342611171117.027.7527.8Immortal time bias in pharmaco-epidemiology. Samy SuissaAm J Epidemiol200818056625No
342722331116.534.5917.3Construction of phylogenetic trees. W M Fitch, E MargoliashScience19675334057No
342811161116.026.6126.6Molecular drive: a cohesive mode of species evolution. G DoverNature19827110332Yes
342911161116.025.6625.7Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis. M M TirionPhys Rev Lett199610063201Yes
343011161116.023.8223.8Complement. Second of two parts. M J WalportN Engl J Med200111297706No
343122321116.049.9625.0Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. P van den Driessche, James WatmoughMath Biosci200212387915Yes
343266961116.0153.4225.6Staging of brain pathology related to sporadic Parkinson's disease. Heiko Braak, Kelly Del Tredici, Udo Rüb, Rob A I de Vos, Ernst N H Jansen Steur, Eva BraakNeurobiol Aging200312498954Yes
343333471115.789.3429.8A nonparametric method for automatic correction of intensity nonuniformity in MRI data. J G Sled, A P Zijdenbos, A C EvansIEEE Trans Med Imaging19989617910Yes
343422301115.069.8634.9Excitatory amino acid transmitters. J C Watkins, R H EvansAnnu Rev Pharmacol Toxicol19816112965No
343533451115.0119.2939.8Neighborhoods and violent crime: a multilevel study of collective efficacy. R J Sampson, S W Raudenbush, F EarlsScience19979252316Yes
343611151115.020.6420.6The ubiquitin-proteasome pathway: on protein death and cell life. A CiechanoverEMBO J19989857172No
343722301115.066.9333.5Software survey: VOSviewer, a computer program for bibliometric mapping. Nees Jan van Eck, Ludo WaltmanScientometrics201020585380Yes
343811151115.069.9970.0Information bias in health research: definition, pitfalls, and adjustment methods. Alaa AlthubaitiJ Multidiscip Healthc201627217764No
343922291114.545.122.6A survey of telomerase activity in human cancer. J W Shay, S BacchettiEur J Cancer19979282118No
344011141114.032.1432.1Studies on histones. 7. Preparative methods for histone fractions from calf thymus. E W JohnsBiochem J19645840387Yes
344111141114.030.930.9On the utility of P3 amplitude as a measure of processing capacity. A KokPsychophysiology200111352145No
344211141114.056.7756.8Patient reported outcome measures could help transform healthcare. Nick BlackBMJ201323358487Yes
344322271113.549.6424.8Obesity and insulin resistance. B B Kahn, J S FlierJ Clin Invest200010953022No
344433401113.3114.1938.1Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. M Hamberg, J Svensson, B SamuelssonProc Natl Acad Sci U S A19751059088Yes
344511131113.034.6234.6Protein damage and degradation by oxygen radicals. I. general aspects. K J DaviesJ Biol Chem19873036875Yes
344622261113.044.8722.4RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. M B Shapiro, P SenapathyNucleic Acids Res19873658675Yes
344711131113.036.9436.9Chemoprevention of cancer. L W WattenbergCancer Res19853880665No
344811131113.040.4340.4Relativistic electronic-structure calculations employing a two-component no-pair formalism with external-field projection operators. B A HessPhys Rev A Gen Phys19869897114Yes
344911131113.035.735.7Social support and health: a review of physiological processes potentially underlying links to disease outcomes. Bert N UchinoJ Behav Med200616758315No
345011131113.025.2425.2The impact of next-generation sequencing technology on genetics. Elaine R MardisTrends Genet200818262675No
345122261113.060.8730.4Mechanisms of mitophagy. Richard J Youle, Derek P NarendraNat Rev Mol Cell Biol201121179058No
345211121112.039.3439.3Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. J N WasserheitSex Transm Dis19921595015No
345311121112.028.4628.5Linkage strategies for genetically complex traits. I. Multilocus models. N RischAm J Hum Genet19902301392Yes
345411121112.026.5226.5Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. S IrwinPsychopharmacologia19685679627Yes
345511121112.032.9332.9Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. M J GassonJ Bacteriol19836403500Yes
345644481112.0116.8229.2Prevalence and trends in obesity among US adults, 1999-2000. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L JohnsonJAMA200212365955Yes
345722241112.00.00.0Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. A H Coons, M H KaplanJ Exp Med195015395569Yes
345822231111.558.9929.5Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. R A Ignotz, J MassaguéJ Biol Chem19863456347Yes
345911111111.026.2726.3Cells in stress: transcriptional activation of heat shock genes. R I MorimotoScience19938451637No
346011111111.033.5733.6Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. P J BasserNMR Biomed19958739270No
346111111111.024.224.2Toward self-organization and complex matter. Jean-Marie LehnScience200211923524Yes
346211111111.025.7825.8Anatomy and regulation of the central melanocortin system. Roger D ConeNat Neurosci200515856065No
346311111111.026.226.2Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. Christopher Paul WildCancer Epidemiol Biomarkers Prev200516103423No
346411111111.00.00.0The Stability of Broken Ends of Chromosomes in Zea Mays. B McClintockGenetics194117247004Yes
346511101110.037.4137.4A review of psychological risk factors in back and neck pain. S J LintonSpine (Phila Pa 1976)200010788861No
346611101110.019.8419.8NFAT proteins: key regulators of T-cell development and function. Fernando MacianNat Rev Immunol200515928679No
346744371109.224.736.2The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. P J Randle, P B Garland, C N Hales, E A NewsholmeLancet196313990765Yes
346822181109.071.4335.7Wine, alcohol, platelets, and the French paradox for coronary heart disease. S Renaud, M de LorgerilLancet19921351198Yes
346911091109.051.0451.0Analysis of Fickian and non-Fickian drug release from polymers. N A PeppasPharm Acta Helv19854011621Yes
347022181109.045.5422.8Genomic control for association studies. B Devlin, K RoederBiometrics199911315092Yes
347111091109.029.129.1Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. F P GuengerichChem Res Toxicol200111409933No
347211091109.025.1225.1Viruses in the sea. Curtis A SuttleNature200516163346No
347311091109.023.6923.7VEGF as a key mediator of angiogenesis in cancer. Peter CarmelietOncology200516301830No
347422181109.054.0827.0Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Herbert Tilg, Alexander R MoschenNat Rev Immunol200616998510No
347522171108.552.0426.0Cellular uptake of the tat protein from human immunodeficiency virus. A D Frankel, C O PaboCell19882849510Yes
347611081108.024.6524.6The molecular biology of leukocyte chemoattractant receptors. P M MurphyAnnu Rev Immunol19948011292No
347711081108.021.0521.1Focal adhesion kinase: the first ten years. J Thomas ParsonsJ Cell Sci200312640026No
347811081108.026.1326.1Differential projections of the infralimbic and prelimbic cortex in the rat. Robert P VertesSynapse200414579424Yes
347911081108.024.524.5Lithium batteries and cathode materials. M Stanley WhittinghamChem Rev200415669156Yes
348033231107.780.5626.9Mechanisms linking obesity to insulin resistance and type 2 diabetes. Steven E Kahn, Rebecca L Hull, Kristina M UtzschneiderNature200617167471No
348122151107.590.5845.3Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. L A Clark, D WatsonJ Abnorm Psychol19911918611No
348211071107.027.4827.5Avidin. N M GreenAdv Protein Chem1975237414Yes
348311071107.022.2822.3Primary response genes induced by growth factors and tumor promoters. H R HerschmanAnnu Rev Biochem19911883198No
348411071107.023.2823.3A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. J MilbrandtScience19873672127Yes
348511071107.027.2227.2The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion. S RosemanChem Phys Lipids19705476326Yes
348611071107.021.3921.4Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. A S BaldwinJ Clin Invest200111160144No
348722141107.047.4823.7Roles of CHOP/GADD153 in endoplasmic reticulum stress. S Oyadomari, M MoriCell Death Differ200414685163No
348822141107.062.9331.5Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Patrick S Ward, Craig B ThompsonCancer Cell201222439925No
348922131106.559.9630.0Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J A Sterne, M EggerJ Clin Epidemiol200111576817Yes
349011061106.051.4151.4Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Y KonoArch Biochem Biophys197824422Yes
349111061106.055.0555.0Osseointegration and its experimental background. P I BrånemarkJ Prosthet Dent19836352924No
349211061106.036.4136.4Socioeconomic disadvantage and child development. V C McLoydAm Psychol19989491747No
349311061106.026.3926.4Quantification of beta-sheet amyloid fibril structures with thioflavin T. H LeVineMethods Enzymol199910507030Yes
349422121106.00.00.0Cortisone in ulcerative colitis; final report on a therapeutic trial. S C Truelove, L J WittsBr Med J195513260656Yes
349511061106.025.7325.7Solid-state nanopores. Cees DekkerNat Nanotechnol200718654264No
349622111105.549.3224.7Synaptic activity and the construction of cortical circuits. L C Katz, C J ShatzScience19968895456No
349711051105.031.7131.7The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. S Nolen-HoeksemaJ Abnorm Psychol200011016119Yes
349822101105.067.3133.7Reactive oxygen species, cellular redox systems, and apoptosis. Magdalena L Circu, Tak Yee AwFree Radic Biol Med201020045723No
349933131104.391.830.6Spirometric reference values from a sample of the general U.S. population. J L Hankinson, J R Odencrantz, K B FedanAm J Respir Crit Care Med19999872837Yes
350011041104.032.6732.7Cognitive and affective development in adolescence. Laurence SteinbergTrends Cogn Sci200515668099No
350111041104.00.00.0Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent. D L MorrisScience194817814729Yes
350211041104.044.0844.1Myeloid-Derived Suppressor Cells. Dmitry I GabrilovichCancer Immunol Res201728052991No
350322071103.527.8413.9Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques. P Gold, S O FreedmanJ Exp Med196514270243Yes
350466191103.2250.4741.7Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Laura J Damschroder, David C Aron, Rosalind E Keith, Susan R Kirsh, Jeffery A Alexander, Julie C LoweryImplement Sci200919664226Yes
350511031103.00.00.0Comparing individual means in the analysis of variance. J W TukeyBiometrics194918151955Yes
350622061103.065.2832.6Chronic hepatitis B: update 2009. Anna S F Lok, Brian J McMahonHepatology200919714720Yes
350722051102.549.824.9A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. J N Cohn, G TognoniN Engl J Med200111759645Yes
350822051102.570.5335.3Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Thomas A Wynn, Thirumalai R RamalingamNat Med201222772564No
350911021102.042.342.3The role of endothelium in the responses of vascular smooth muscle to drugs. R F FurchgottAnnu Rev Pharmacol Toxicol19846203480No
351011021102.029.9229.9Aging, energy, and oxidative stress in neurodegenerative diseases. M F BealAnn Neurol19957668820No
351111021102.027.3927.4The Trk family of neurotrophin receptors. M BarbacidJ Neurobiol19947852993No
351211021102.028.1828.2Neuropathology of Parkinson's disease. L S FornoJ Neuropathol Exp Neurol19968786384No
351333061102.065.8321.9SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. Jay D Horton, Joseph L Goldstein, Michael S BrownJ Clin Invest200211994399No
351444071101.8148.9437.2Prevalence and trends in obesity among US adults, 1999-2008. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R CurtinJAMA201020071471Yes
351511011101.039.6639.7Methods for dealing with reaction time outliers. R RatcliffPsychol Bull19938272468Yes
351611011101.00.00.0Cleavage of the haem-protein link by acid methylethylketone. F W TealeBiochim Biophys Acta195913837237Yes
351766051100.8173.0528.8Prediction of coronary heart disease using risk factor categories. P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B KannelCirculation19989603539Yes
351822011100.581.9441.0Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. I B Wilson, P D ClearyJAMA19957996652Yes
351911001100.023.0423.0T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. R H SchwartzAnnu Rev Immunol19852415139No
352011001100.024.5824.6Current concepts of the pathogenesis of the acute coronary syndromes. P LibbyCirculation200111457759No
352111001100.022.0122.0Models, mechanisms and clinical evidence for cancer dormancy. Julio A Aguirre-GhisoNat Rev Cancer200717957189No
352211001100.045.0845.1How does sexual minority stigma "get under the skin"? A psychological mediation framework. Mark L HatzenbuehlerPsychol Bull200919702379No
352311001100.037.4337.4Globalization of diabetes: the role of diet, lifestyle, and genes. Frank B HuDiabetes Care201121617109No
352421991099.538.2519.1A synthetic oscillatory network of transcriptional regulators. M B Elowitz, S LeiblerNature200010659856Yes
352521991099.550.8725.4The host defense of Drosophila melanogaster. Bruno Lemaitre, Jules HoffmannAnnu Rev Immunol200717201680No
352632981099.394.4731.5Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Geoffrey R Norman, Jeff A Sloan, Kathleen W WyrwichMed Care200312719681No
352710991099.042.9943.0A simple method for determination of serum catalase activity and revision of reference range. L GóthClin Chim Acta19912029780Yes
352810991099.029.9129.9Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. S G JohnsenHormones19705527187Yes
352910991099.019.6719.7Time-dependent processes in memory storage. J L McGaughScience19665917768Yes
353021981099.049.1524.6Cell cycle control and cancer. L H Hartwell, M B KastanScience19947997877No
353121981099.057.9229.0Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. I Chopra, M RobertsMicrobiol Mol Biol Rev200111381101Yes
353221981099.052.4126.2Reducing the dimensionality of data with neural networks. G E Hinton, R R SalakhutdinovScience200616873662Yes
353321971098.563.4531.7The acute phase response. H Baumann, J GauldieImmunol Today19947512342No
353421961098.051.725.9T antigen is bound to a host protein in SV40-transformed cells. D P Lane, L V CrawfordNature1979218111Yes
353521961098.045.4922.7p53: puzzle and paradigm. L J Ko, C PrivesGenes Dev19968654922No
353610981098.022.3522.4Osmotic stress signaling and osmoadaptation in yeasts. Stefan HohmannMicrobiol Mol Biol Rev200212040128No
353710981098.022.8122.8Membrane recognition by phospholipid-binding domains. Mark A LemmonNat Rev Mol Cell Biol200818216767No
353821961098.085.8342.9Long Noncoding RNAs in Cancer Pathways. Adam M Schmitt, Howard Y ChangCancer Cell201627070700No
353910971097.033.4233.4Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. D L ColemanDiabetologia1978350680No
354010971097.020.320.3Chronic myeloid leukemia. C L SawyersN Engl J Med199910219069No
354121931096.570.3535.2Central sensitization: a generator of pain hypersensitivity by central neural plasticity. Alban Latremoliere, Clifford J WoolfJ Pain200919712899No
354210961096.019.0219.0Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. R RothsteinMethods Enzymol19912005793Yes
354310961096.025.1325.1The prefrontal cortex--an update: time is of the essence. J M FusterNeuron200111394996No
354410961096.025.7325.7Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures. Frank WürthnerChem Commun (Camb)200415263926Yes
354521921096.057.5328.8Localized surface plasmon resonance spectroscopy and sensing. Katherine A Willets, Richard P Van DuyneAnnu Rev Phys Chem200717067281No
354610961096.022.9723.0Phenotypic plasticity and the epigenetics of human disease. Andrew P FeinbergNature200717522677No
354710961096.024.224.2Personal genomes: The case of the missing heritability. Brendan MaherNature200818987709No
354810961096.039.7739.8Visual attention: the past 25 years. Marisa CarrascoVision Res201121549742No
354921911095.566.1633.12,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. A Poland, J C KnutsonAnnu Rev Pharmacol Toxicol19826282188No
355021901095.077.6938.8Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. A I Basbaum, H L FieldsAnnu Rev Neurosci19846143527No
355110951095.00.00.0Motivation reconsidered: the concept of competence. R W WhitePsychol Rev195913844397Yes
355210951095.00.00.0The purine and pyrimidine composition of deoxypentose nucleic acids. G R WyattBiochem J195114838906Yes
355321901095.053.7926.9Quorum sensing: cell-to-cell communication in bacteria. Christopher M Waters, Bonnie L BasslerAnnu Rev Cell Dev Biol200516212498No
355421901095.063.2831.6Relaxing the rule of ten events per variable in logistic and Cox regression. Eric Vittinghoff, Charles E McCullochAm J Epidemiol200717182981Yes
355521891094.545.7822.9The Hsp70 and Hsp60 chaperone machines. B Bukau, A L HorwichCell19989476895No
355610941094.020.7620.8Luciferase reporter gene vectors for analysis of promoters and enhancers. S K NordeenBiotechniques19882908509Yes
355710941094.027.7127.7Two distinct classes of carbohydrate-recognition domains in animal lectins. K DrickamerJ Biol Chem19883290208No
355810941094.043.0543.0Corticosteroids and lymphoid cells. H N ClamanN Engl J Med19725043524Yes
355910941094.022.422.4mRNA stability in mammalian cells. J RossMicrobiol Rev19957565413No
356010941094.032.3432.3Spatially heterogeneous dynamics in supercooled liquids. M D EdigerAnnu Rev Phys Chem200011031277Yes
356110941094.027.2727.3Pathogenesis of osteoporosis: concepts, conflicts, and prospects. Lawrence G RaiszJ Clin Invest200516322775No
356232811093.7101.5933.9PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. J W Varni, M Seid, P S KurtinMed Care200111468499Yes
356332811093.776.0225.3Obesity induces a phenotypic switch in adipose tissue macrophage polarization. Carey N Lumeng, Jennifer L Bodzin, Alan R SaltielJ Clin Invest200717200717Yes
356454681093.6231.7146.3Integrating single-cell transcriptomic data across different conditions, technologies, and species. Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi, Rahul SatijaNat Biotechnol201829608179Yes
356521871093.574.5437.3Consensus methods for medical and health services research. J Jones, D HunterBMJ19957640549No
356632791093.098.3732.8Depression: a new animal model sensitive to antidepressant treatments. R D Porsolt, M Le Pichon, M JalfreNature1977559941Yes
356710931093.027.7127.7Selectins: interpreters of cell-specific carbohydrate information during inflammation. L A LaskyScience19921439808No
356810931093.018.8318.8Cell lines derived from late embryonic stages of Drosophila melanogaster. I SchneiderJ Embryol Exp Morphol19724625067Yes
356910931093.034.034.0The oxidation hypothesis of atherosclerosis. J L WitztumLancet19947916078No
357010931093.025.2825.3P-450 metabolites of arachidonic acid in the control of cardiovascular function. Richard J RomanPhysiol Rev200211773611No
357165581093.0142.3923.7Obesity is associated with macrophage accumulation in adipose tissue. Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W FerranteJ Clin Invest200314679176Yes
357210931093.028.1728.2Ovarian cancer development and metastasis. Ernst LengyelAm J Pathol201020651229Yes
357321861093.094.5747.3Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. Peter C Austin, Elizabeth A StuartStat Med201526238958No
357410921092.027.9427.9Glutathione and its role in cellular functions. H SiesFree Radic Biol Med199910569624No
357576431091.9238.3834.1Toxicity and response criteria of the Eastern Cooperative Oncology Group. M M Oken, R H Creech, D C Tormey, J Horton, T E Davis, E T McFadden, P P CarboneAm J Clin Oncol19827165009Yes
357654581091.6115.0523.0The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. J W Harper, G R Adami, N Wei, K Keyomarsi, S J ElledgeCell19938242751Yes
357710911091.031.9531.9Tests for emotionality in rats and mice: a review. J ArcherAnim Behav19734578750No
357810911091.029.329.3A kinetic photometric method for serum gamma-glutamyl transpeptidase. G SzaszClin Chem19695773262Yes
357910911091.032.6832.7Social support and patient adherence to medical treatment: a meta-analysis. M Robin DiMatteoHealth Psychol200415008666Yes
358054521090.4163.9832.8Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. Salim Yusuf, Bertram Pitt, Clarence E Davis, William B Hood, Jay N CohnN Engl J Med19912057034Yes
358132711090.3177.8959.3Hepatocellular carcinoma. Alejandro Forner, María Reig, Jordi BruixLancet201829307467No
358210901090.038.2838.3Spin trapping: ESR parameters of spin adducts. G R BuettnerFree Radic Biol Med19872826304No
358310901090.00.00.0Aniline hydrogen phthalate as a spraying reagent for chromatography of sugars. S M PartridgeNature194918140444Yes
358421791089.581.8140.9Understanding face recognition. V Bruce, A YoungBr J Psychol19863756376Yes
358521791089.543.7121.9Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. P E Wright, H J DysonJ Mol Biol199910550212No
358621781089.049.9725.0Hepatitis C virus infection. G M Lauer, B D WalkerN Engl J Med200111439948No
358765311088.5159.5426.6Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. S Yusuf, P Sleight, J Pogue, J Bosch, R Davies, G DagenaisN Engl J Med200010639539Yes
358821771088.574.4337.2The complexity of NF-κB signaling in inflammation and cancer. Bastian Hoesel, Johannes A SchmidMol Cancer201323915189No
358921761088.068.9134.5Glutamate and the pathophysiology of hypoxic--ischemic brain damage. S M Rothman, J W OlneyAnn Neurol19862421636No
359010881088.024.6524.6Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system. T IkemuraJ Mol Biol19816175758Yes
359110881088.027.5827.6Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. M J BerridgeBiochem J19836309155Yes
359210881088.019.7219.7Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. R A FryeBiochem Biophys Res Commun200010873683Yes
359310881088.00.00.0The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs. M VogtJ Physiol195413152692Yes
359410881088.07.917.9Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. R M BerneAm J Physiol196313971060Yes
359510881088.025.8625.9Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. Thomas A WynnJ Clin Invest200717332879No
359610881088.023.3623.4Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. Michael ForgacNat Rev Mol Cell Biol200717912264No
359710871087.022.9723.0Twilight zone of protein sequence alignments. B RostProtein Eng199910195279Yes
359810871087.026.8626.9Seed Germination and Dormancy. J. D. BewleyPlant Cell199712237375Yes
359921741087.064.1732.1Are the dorsal and ventral hippocampus functionally distinct structures? Michael S Fanselow, Hong-Wei DongNeuron201020152109No
360021731086.50.00.0Micromethod for the direct determination of serum triglycerides. E Van Handel, D B ZilversmitJ Lab Clin Med195713439279Yes
360121731086.547.9224.0Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. Daniel J Hicklin, Lee M EllisJ Clin Oncol200515585754No
360210861086.037.2237.2Multiple organ failure. Pathophysiology and potential future therapy. E A DeitchAnn Surg19921503516No
360310861086.054.9555.0The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. J A KoufmanLaryngoscope19911895864No
360410861086.030.8630.9Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. T FeiziNature19852579340Yes
360510861086.026.626.6DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. J F WardProg Nucleic Acid Res Mol Biol19883065826No
360610861086.023.3623.4PHD: predicting one-dimensional protein structure by profile-based neural networks. B RostMethods Enzymol19968743704Yes
360710861086.023.923.9Molecular mechanisms of myocardial remodeling. B SwynghedauwPhysiol Rev19999922372No
360810861086.033.733.7Lanthanide luminescence for biomedical analyses and imaging. Jean-Claude G BünzliChem Rev201020151630No
360921711085.551.0325.5Peroxidase-labeled antibody. A new method of conjugation. P K Nakane, A KawaoiJ Histochem Cytochem19744443551Yes
361010851085.020.620.6At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. M KozakJ Mol Biol19873681984Yes
361110851085.032.5232.5A teacher rating scale for use in drug studies with children. C K ConnersAm J Psychiatry19694900822Yes
361210851085.020.3120.3Progress in human tumour immunology and immunotherapy. S A RosenbergNature200111357146No
361310851085.023.7623.8New ideas about atrial fibrillation 50 years on. Stanley NattelNature200211805846No
361410851085.046.2446.2A comprehensive review on metabolic syndrome. Jaspinder KaurCardiol Res Pract201424711954No
361521691084.579.8639.9The Modified Mini-Mental State (3MS) examination. E L Teng, H C ChuiJ Clin Psychiatry19873611032Yes
361665061084.3167.6427.9The capsaicin receptor: a heat-activated ion channel in the pain pathway. M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D JuliusNature19979349813Yes
361710841084.032.9533.0Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. P StastnyN Engl J Med1978147420Yes
361810841084.061.9461.9The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture. J CasselAm J Epidemiol1976782233No
361910841084.041.7541.8A new international staging system for lung cancer. C F MountainChest19863514171No
362010841084.025.1425.1Selectins and their ligands: current concepts and controversies. G S KansasBlood19968896391No
362121681084.00.00.0A revision of the Schoenheimer-Sperry method for cholesterol determination. W M Sperry, M WebbJ Biol Chem195014794694Yes
362210841084.029.7829.8Cholinesterase inhibitors for Alzheimer's disease. J BirksCochrane Database Syst Rev200616437532No
362321671083.581.7140.9Visual search and stimulus similarity. J Duncan, G W HumphreysPsychol Rev19892756067Yes
362410831083.058.058.0The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement. M M PanjabiJ Spinal Disord19921490034Yes
362510831083.020.9120.9Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities. F FonnumBiochem J19694982085Yes
362610831083.00.00.0Asymptomatic infections of the urinary tract. E H KassTrans Assoc Am Physicians195613380946Yes
362710831083.08.448.4The Permeability Of Capillaries In Various Organs As Determined By Use Of The 'Indicator Diffusion' Method. C CroneActa Physiol Scand196314078649Yes
362810831083.046.046.0CONSORT-EHEALTH: improving and standardizing evaluation reports of Web-based and mobile health interventions. Gunther EysenbachJ Med Internet Res201122209829No
362921651082.547.2623.6Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. T Hunter, J PinesCell19947954824No
363021641082.067.0733.5Mental rotation of three-dimensional objects. R N Shepard, J MetzlerScience19715540314Yes
363110821082.025.1625.2BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data. O GascuelMol Biol Evol19979254330Yes
363210821082.030.4930.5Limbic-cortical dysregulation: a proposed model of depression. H S MaybergJ Neuropsychiatry Clin Neurosci19979276848No
363310821082.033.133.1On the mechanisms of biocompatibility. David F WilliamsBiomaterials200818440630No
363443281082.0207.1951.8Genome sequence-based species delimitation with confidence intervals and improved distance functions. Jan P Meier-Kolthoff, Alexander F Auch, Hans-Peter Klenk, Markus GökerBMC Bioinformatics201323432962Yes
363521631081.565.0432.5A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. J J Sedmak, S E GrossbergAnal Biochem197768686Yes
363621631081.545.2522.6Mitogen-activated protein kinase pathways. M J Robinson, M H CobbCurr Opin Cell Biol19979069255No
363721621081.063.4431.7Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. J M Reul, E R de KloetEndocrinology19852998738Yes
363810811081.025.525.5Nitric oxide, oxidants, and protein tyrosine nitration. Rafael RadiProc Natl Acad Sci U S A200415020765Yes
363910811081.027.1927.2Fibrinogen and fibrin structure and functions. M W MosessonJ Thromb Haemost200516102057No
364010801080.030.1830.2Transport of molecules in the tumor interstitium: a review. R K JainCancer Res19873555767No
364110801080.028.4928.5Microtubule formation in vitro in solutions containing low calcium concentrations. R C WeisenbergScience19724626639Yes
364210801080.035.9435.9Why we need observational studies to evaluate the effectiveness of health care. N BlackBMJ19968634569Yes
364310801080.021.421.4Coiled coils: new structures and new functions. A LupasTrends Biochem Sci19968918191No
364410801080.00.00.0The effect of emotion on cue utilization and the organization of behavior. J A EasterbrookPsychol Rev195913658305Yes
364510801080.021.4321.4Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution. Mats G L GustafssonProc Natl Acad Sci U S A200516141335Yes
364610801080.042.5342.5Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. Konrad M AndrassyKidney Int201323989362Yes
364721591079.583.8141.9Glutathione reductase. I Carlberg, B MannervikMethods Enzymol19853003504Yes
364821591079.560.4930.2ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control. Graham Noctor, Christine H. FoyerAnnu Rev Plant Physiol Plant Mol Biol199815012235Yes
364921591079.561.3830.7Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. Ivan Sondi, Branka Salopek-SondiJ Colloid Interface Sci200415158396Yes
365064741079.0139.0523.2Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. D A Melton, P A Krieg, M R Rebagliati, T Maniatis, K Zinn, M R GreenNucleic Acids Res19846091052Yes
365110791079.022.3322.3Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. Z YangMol Biol Evol19989580986Yes
365221581079.060.3530.2Burden of major musculoskeletal conditions. Anthony D Woolf, Bruce PflegerBull World Health Organ200314710506No
365310791079.020.7920.8mTOR and cancer: insights into a complex relationship. David M SabatiniNat Rev Cancer200616915295No
365410791079.039.6639.7The pathobiology of vascular dementia. Costantino IadecolaNeuron201324267647No
365521581079.0104.6252.3Functional Classification and Experimental Dissection of Long Noncoding RNAs. Florian Kopp, Joshua T MendellCell201829373828No
365643151078.8242.8460.7The Cambridge Structural Database. Colin R Groom, Ian J Bruno, Matthew P Lightfoot, Suzanna C WardActa Crystallogr B Struct Sci Cryst Eng Mater201627048719Yes
365721571078.575.6237.8A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. Walter J Paulus, Carsten TschöpeJ Am Coll Cardiol201323684677No
365832351078.384.4428.1Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. M K Parmar, V Torri, L StewartStat Med19989921604Yes
365910781078.018.8518.9Regulatory T cells in autoimmmunity*. E M ShevachAnnu Rev Immunol200010837065No
366010781078.038.0838.1Epidemiology of heart failure. Véronique L RogerCirc Res201323989710No
366121551077.582.2641.1The Posttraumatic Growth Inventory: measuring the positive legacy of trauma. R G Tedeschi, L G CalhounJ Trauma Stress19968827649Yes
366210771077.024.7924.8Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. E M TanAdv Immunol19892646863No
366310771077.021.3721.4Protein denaturation. C. Theoretical models for the mechanism of denaturation. C TanfordAdv Protein Chem19704912353No
366410771077.018.2918.3Molecular mechanisms of axon guidance. Barry J DicksonScience200212471249No
366510771077.029.229.2Ion suppression in mass spectrometry. Thomas M AnnesleyClin Chem200312816898No
366610771077.00.00.0The stereotaxic method and radiosurgery of the brain. L LeksellActa Chir Scand195114914373Yes
366710771077.028.4328.4Abiotic stress, the field environment and stress combination. Ron MittlerTrends Plant Sci200616359910No
366810761076.041.8741.9Functional connections between cells as revealed by dye-coupling with a highly fluorescent naphthalimide tracer. W W StewartCell1978688392Yes
366921521076.043.621.8In search of the 'missing self': MHC molecules and NK cell recognition. H G Ljunggren, K KärreImmunol Today19902201309No
367021521076.096.5848.3Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. J B Mulliken, J GlowackiPlast Reconstr Surg19827063565Yes
367110761076.036.0236.0Lipid peroxidation and antioxidants as biomarkers of tissue damage. J M GutteridgeClin Chem19957497639No
367243041076.0156.9339.2Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. K F Schulz, I Chalmers, R J Hayes, D G AltmanJAMA19957823387Yes
367310761076.026.4826.5Biological effects of resveratrol. L FrémontLife Sci200010680575No
367410761076.028.4928.5Invited review: Aging and sarcopenia. Timothy J DohertyJ Appl Physiol (1985)200312970377No
367510761076.029.0529.1What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. Michael A BabyakPsychosom Med200415184705Yes
367610761076.030.1230.1The locus coeruleus and noradrenergic modulation of cognition. Susan J SaraNat Rev Neurosci200919190638No
367732251075.0114.9338.3Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. P S Walsh, D A Metzger, R HiguchiBiotechniques19911867860Yes
367810751075.015.9916.0The moulding of senescence by natural selection. W D HamiltonJ Theor Biol19666015424Yes
367910751075.037.8137.8Coronary physiology. E O FeiglPhysiol Rev19836296890No
368010751075.040.1840.2Beyond curriculum reform: confronting medicine's hidden curriculum. F W HaffertyAcad Med19989580717Yes
368121501075.039.719.9AP-1 as a regulator of cell life and death. Eitan Shaulian, Michael KarinNat Cell Biol200211988758No
368210751075.028.9929.0A perspective on judgment and choice: mapping bounded rationality. Daniel KahnemanAm Psychol200314584987No
368310751075.027.4427.4Redefining oxidative stress. Dean P JonesAntioxid Redox Signal200616987039No
368410751075.025.825.8ImageJ for microscopy. Tony J CollinsBiotechniques200717936939No
368521501075.0248.57124.3Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. David J Newman, Gordon M CraggJ Nat Prod202032162523No
368632241074.763.1521.1Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Paola Scaffidi, Tom Misteli, Marco E BianchiNature200212110890Yes
368710741074.027.4227.4Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. J P TamProc Natl Acad Sci U S A19883399498Yes
368810741074.033.3133.3Food reward: brain substrates of wanting and liking. K C BerridgeNeurosci Biobehav Rev19968622814No
368910741074.023.4423.4ECM and cell surface proteolysis: regulating cellular ecology. Z WerbCell19979390552No
369021471073.583.7341.9Chronic catheterization of the spinal subarachnoid space. T L Yaksh, T A RudyPhysiol Behav197614677603Yes
369121461073.082.6741.3Hearing lips and seeing voices. H McGurk, J MacDonaldNature19761012311Yes
369210731073.029.8429.8Mitochondrial genetics: a paradigm for aging and degenerative diseases? D C WallaceScience19921533953Yes
369310731073.056.0456.0The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. G A IlizarovClin Orthop Relat Res19892912628Yes
369410731073.028.6328.6Statistical quality control and routine data processing for radioimmunoassays and immunoradiometric assays. D RodbardClin Chem19744370388No
369510731073.031.0731.1Microbial heavy-metal resistance. D H NiesAppl Microbiol Biotechnol199910422221No
369621461073.041.7320.9STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Hiroki Ishikawa, Glen N BarberNature200818724357Yes
369710731073.028.3228.3Bile acids: regulation of synthesis. John Y L ChiangJ Lipid Res200919346330No
369810721072.018.1918.2Evolution and tinkering. F JacobScience1977860134Yes
369921441072.043.0721.5A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. C S Hoffman, F WinstonGene19873319781Yes
370010721072.026.3326.3Anti-inflammatory actions of glucocorticoids: molecular mechanisms. P J BarnesClin Sci (Lond)19989854452No
370121441072.054.2627.1Antibacterial resistance worldwide: causes, challenges and responses. Stuart B Levy, Bonnie MarshallNat Med200415577930No
370264311071.8174.2329.0Cancer statistics, 2007. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Taylor Murray, Jiaquan Xu, Michael J ThunCA Cancer J Clin200717237035Yes
370353581071.6298.9459.8ModelFinder: fast model selection for accurate phylogenetic estimates. Subha Kalyaanamoorthy, Bui Quang Minh, Thomas K F Wong, Arndt von Haeseler, Lars S JermiinNat Methods201728481363Yes
370421431071.571.7535.9The pathogenesis of atherosclerosis (first of two parts). R Ross, J A GlomsetN Engl J Med1976819830No
370521431071.533.1116.6The growth of mouse bone marrow cells in vitro. T R Bradley, D MetcalfAust J Exp Biol Med Sci19664164182Yes
370621431071.546.0723.0Finding and evaluating community structure in networks. M E J Newman, M GirvanPhys Rev E Stat Nonlin Soft Matter Phys200414995526Yes
370721431071.565.3632.7Ischemia and reperfusion--from mechanism to translation. Holger K Eltzschig, Tobias EckleNat Med201122064429No
370810711071.031.1831.2Why people use health services. I M RosenstockMilbank Mem Fund Q19665967464Yes
370910711071.029.5229.5Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. John W NewcomerCNS Drugs200515998156No
371021411070.560.2630.1Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Amit Etkin, Tor D WagerAm J Psychiatry200717898336Yes
371121401070.060.1330.1Binding of soluble form of fibroblast surface protein, fibronectin, to collagen. E Engvall, E RuoslahtiInt J Cancer1977903179Yes
371210701070.050.550.5Clinical experience with impedance audiometry. J JergerArch Otolaryngol19705455571Yes
371310701070.029.5729.6Principles of c-di-GMP signalling in bacteria. Regine HenggeNat Rev Microbiol200919287449No
371432091069.7126.6742.2Concurrent and predictive validity of a self-reported measure of medication adherence. D E Morisky, L W Green, D M LevineMed Care19863945130Yes
371532091069.7151.7450.6Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG) P L Hudak, P C Amadio, C BombardierAm J Ind Med19968773720Yes
371632091069.775.2625.1Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis. Sang-Dong Yoo, Young-Hee Cho, Jen SheenNat Protoc200717585298Yes
371742781069.5110.2727.6A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. I Vermes, C Haanen, H Steffens-Nakken, C ReutelingspergerJ Immunol Methods19957622868Yes
371821391069.575.6837.8Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. Hirenkumar K Makadia, Steven J SiegelPolymers (Basel)201122577513Yes
371921391069.591.6245.8The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities. Samuel Genheden, Ulf RydeExpert Opin Drug Discov201525835573No
372021381069.074.4837.2A formula to estimate the approximate surface area if height and weight be known. 1916. D Du Bois, E F Du BoisNutrition19892520314No
372110691069.027.0927.1Axonal growth-associated proteins. J H SkeneAnnu Rev Neurosci19892648946No
372210691069.030.830.8Muscarinic receptors--characterization, coupling and function. M P CaulfieldPharmacol Ther19937504306No
372310691069.023.9924.0Liver regeneration. George K MichalopoulosJ Cell Physiol200717559071No
372421371068.537.5218.8Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. W Gu, R G RoederCell19979288740Yes
372542731068.2109.5627.4Real time quantitative PCR. C A Heid, J Stevens, K J Livak, P M WilliamsGenome Res19968908518Yes
372621361068.090.8545.4Severe psoriasis--oral therapy with a new retinoid. T Fredriksson, U PetterssonDermatologica1978357213Yes
372710681068.034.1234.1A colorimetric method for estimating serum triglycerides. M J FletcherClin Chim Acta19685696963Yes
372810681068.025.8825.9The ultrastructural basis of capillary permeability studied with peroxidase as a tracer. M J KarnovskyJ Cell Biol19676061717Yes
372942691067.2217.6954.4National Institute of Mental Health Diagnostic Interview Schedule. Its history, characteristics, and validity. L N Robins, J E Helzer, J Croughan, K S RatcliffArch Gen Psychiatry19816260053Yes
373010671067.030.2930.3Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine. E M TanAdv Immunol19826182766No
373110671067.032.7332.7Social cognition and the brain: a meta-analysis. Frank Van OverwalleHum Brain Mapp200918381770Yes
373210671067.031.2731.3Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Gregg L SemenzaTrends Pharmacol Sci201222398146No
373310671067.072.572.5Non-alcoholic fatty liver disease - A global public health perspective. Zobair M YounossiJ Hepatol201930414863No
373432001066.7119.2639.8Stimuli-responsive nanocarriers for drug delivery. Simona Mura, Julien Nicolas, Patrick CouvreurNat Mater201324150417No
373531981066.0142.6647.6Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. M Jondal, G Holm, H WigzellJ Exp Med19724114496Yes
373610661066.026.5626.6The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. David S LudwigJAMA200211988062No
373710661066.025.5725.6Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. Mark E BoutonBiol Psychiatry200212437938No
373810661066.024.1224.1The neurobiology of consolidations, or, how stable is the engram? Yadin DudaiAnnu Rev Psychol200414744210No
373910661066.028.4228.4An introduction to data reduction: space-group determination, scaling and intensity statistics. Philip R EvansActa Crystallogr D Biol Crystallogr201121460446Yes
374010661066.037.3237.3Stochastic thermodynamics, fluctuation theorems and molecular machines. Udo SeifertRep Prog Phys201223168354No
374121311065.542.1821.1Calcium-dependent bacteriophage DNA infection. M Mandel, A HigaJ Mol Biol19704922220Yes
374210651065.021.821.8The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells. D MetcalfNature19892469962No
374310651065.027.9628.0Philosophical conceptions of the self: implications for cognitive science. I GallagherTrends Cogn Sci200010637618Yes
374410651065.030.1630.2The mechanisms of alloxan- and streptozotocin-induced diabetes. S LenzenDiabetologia200818087688No
374510651065.055.0555.0Systematic text condensation: a strategy for qualitative analysis. Kirsti MalterudScand J Public Health201223221918Yes
374610651065.045.8745.9Bisphenol A and human health: a review of the literature. Johanna R RochesterReprod Toxicol201323994667No
374721291064.562.6631.3Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. C N Hales, D J BarkerDiabetologia19921644236No
374863871064.5176.9929.5Mild cognitive impairment: clinical characterization and outcome. R C Petersen, G E Smith, S C Waring, R J Ivnik, E G Tangalos, E KokmenArch Neurol199910190820Yes
374910641064.025.5825.6The granulocyte-macrophage colony-stimulating factors. D MetcalfScience19852990035No
375010641064.022.1122.1Oxidant signals and oxidative stress. Toren FinkelCurr Opin Cell Biol200312648682No
375131921064.067.3622.55-fluorouracil: mechanisms of action and clinical strategies. Daniel B Longley, D Paul Harkin, Patrick G JohnstonNat Rev Cancer200312724731No
375210641064.025.8625.9Looking into the functional architecture of the brain with diffusion MRI. Denis Le BihanNat Rev Neurosci200312778119No
375321281064.054.1127.1Anemia of chronic disease. Guenter Weiss, Lawrence T GoodnoughN Engl J Med200515758012No
375410641064.024.6124.6Structure and signalling in the IL-17 receptor family. Sarah L GaffenNat Rev Immunol200919575028No
3755106341063.4350.4935.0The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. N K Aaronson, S Ahmedzai, B Bergman, M Bullinger, A Cull, N J Duez, A Filiberti, H Flechtner, S B Fleishman, J C de HaesJ Natl Cancer Inst19938433390Yes
375610631063.038.6438.6Attention, similarity, and the identification-categorization relationship. R M NosofskyJ Exp Psychol Gen19862937873Yes
375710631063.029.8629.9Junctional intercellular communication: the cell-to-cell membrane channel. W R LoewensteinPhysiol Rev19816270711No
375810631063.029.1829.2Synchronization of cortical activity and its putative role in information processing and learning. W SingerAnnu Rev Physiol19938466179No
375910631063.022.8322.8Ligand-targeted therapeutics in anticancer therapy. Theresa M AllenNat Rev Cancer200212360278No
376010631063.029.9529.9Micellar nanocarriers: pharmaceutical perspectives. V P TorchilinPharm Res200717109211No
376121261063.051.9326.0Sulforhodamine B colorimetric assay for cytotoxicity screening. Vanicha Vichai, Kanyawim KirtikaraNat Protoc200617406391Yes
376210631063.00.00.0A Serological Differentiation Of Human And Other Groups Of Hemolytic Streptococci. R C LancefieldJ Exp Med193319870148Yes
3763116901062.7331.3230.1International physical activity questionnaire: 12-country reliability and validity. Cora L Craig, Alison L Marshall, Michael Sjöström, Adrian E Bauman, Michael L Booth, Barbara E Ainsworth, Michael Pratt, Ulf Ekelund, Agneta Yngve, James F Sallis, Pekka OjaMed Sci Sports Exerc200312900694Yes
376453121062.4194.3738.9A new clinical scale for the staging of dementia. C P Hughes, L Berg, W L Danziger, L A Coben, R L MartinBr J Psychiatry19827104545Yes
376521241062.053.2126.6The regulation and function of c-fos and other immediate early genes in the nervous system. M Sheng, M E GreenbergNeuron19901969743No
376610621062.032.6432.6Prevention of drug access to bacterial targets: permeability barriers and active efflux. H NikaidoScience19948153625No
376721241062.00.00.0Histochemistry of hepatic phosphatases of a physiologic pH; with special reference to the demonstration of bile canaliculi. M Wachstein, E MeiselAm J Clin Pathol195713410831Yes
376821241062.00.00.0Use of glucose oxidase, peroxidase, and O-dianisidine in determination of blood and urinary glucose. A S Huggett, D A NixonLancet195713464070Yes
376921231061.568.6834.3Polymyositis and dermatomyositis (second of two parts). A Bohan, J B PeterN Engl J Med19751089199No
377021231061.556.3628.2The evolution of cooperation. R Axelrod, W D HamiltonScience19817466396Yes
377121231061.572.6536.3Photoacoustic tomography: in vivo imaging from organelles to organs. Lihong V Wang, Song HuScience201222442475No
377263681061.3161.7227.0Ghrelin is a growth-hormone-releasing acylated peptide from stomach. M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K KangawaNature199910604470Yes
377342451061.2101.1425.3The epidemiology of sepsis in the United States from 1979 through 2000. Greg S Martin, David M Mannino, Stephanie Eaton, Marc MossN Engl J Med200312700374Yes
377410611061.031.6531.6Epidemiology of cancer of the colon and rectum. D P BurkittCancer19715165022Yes
377510611061.030.4530.4Pathogenetic mechanisms of septic shock. J E ParrilloN Engl J Med19938479467No
377621221061.048.0624.0Effect of pegylation on pharmaceuticals. J Milton Harris, Robert B ChessNat Rev Drug Discov200312612647No
377731811060.380.8727.0Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions. M Piotto, V Saudek, V SklenárJ Biomol NMR19921490109Yes
377810601060.043.2943.3Movement, posture and equilibrium: interaction and coordination. J MassionProg Neurobiol19921736324No
377910601060.052.3352.3The sociological study of stress. L I PearlinJ Health Soc Behav19892674272No
378010601060.029.8229.8Determination of total protein. G L PetersonMethods Enzymol19836855607Yes
378110601060.041.5541.5Gait changes in older adults: predictors of falls or indicators of fear. B E MakiJ Am Geriatr Soc19979063277Yes
378221201060.040.1720.1Wnt signaling: a common theme in animal development. K M Cadigan, R NusseGenes Dev19979407023No
378310601060.028.4128.4Inhibition of return. R M KleinTrends Cogn Sci200010740278Yes
378410601060.00.00.0On the Absorption of Fluids from the Connective Tissue Spaces. E H StarlingJ Physiol189616992325Yes
378510601060.00.00.0Cell deaths in normal vertebrate ontogeny. A GlucksmannBiol Rev Camb Philos Soc195124540363Yes
378652991059.8144.0728.8Biodiversity hotspots for conservation priorities. N Myers, R A Mittermeier, C G Mittermeier, G A da Fonseca, J KentNature200010706275Yes
378721191059.561.9431.0The biochemistry of P-glycoprotein-mediated multidrug resistance. J A Endicott, V LingAnnu Rev Biochem19892570548No
378842371059.2105.9426.5An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Joseph A Maldjian, Paul J Laurienti, Robert A Kraft, Jonathan H BurdetteNeuroimage200312880848Yes
378910591059.039.3339.3Infection by verocytotoxin-producing Escherichia coli. M A KarmaliClin Microbiol Rev19892644022No
379021181059.00.00.0A microcolorimetric method for the determination of inorganic phosphorus. H H Taussky, E ShorrJ Biol Chem195313061491Yes
379110591059.028.3428.3Neuronal gamma-band synchronization as a fundamental process in cortical computation. Pascal FriesAnnu Rev Neurosci200919400723No
379221181059.078.5139.3Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. Claudio Franceschi, Judith CampisiJ Gerontol A Biol Sci Med Sci201424833586No
379321171058.554.027.0Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. M S Brown, J L GoldsteinAnnu Rev Biochem19836311077No
379421171058.547.9624.0The significance of digital gene expression profiles. S Audic, J M ClaverieGenome Res19979331369Yes
379510581058.024.4624.5Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. S H KaufmannCancer Res19892790800Yes
379621161058.045.3322.7The immunoglobulin superfamily--domains for cell surface recognition. A F Williams, A N BarclayAnnu Rev Immunol19883289571No
379710581058.026.9226.9From Microporous to Mesoporous Molecular Sieve Materials and Their Use in Catalysis. Avelino CormaChem Rev199711848903Yes
379810581058.027.1927.2Unequal treatment: confronting racial and ethnic disparities in health care. Alan NelsonJ Natl Med Assoc200212152921No
379910581058.026.6426.6The potential environmental impact of engineered nanomaterials. Vicki L ColvinNat Biotechnol200314520401Yes
380010581058.00.00.0Neural basis of the spontaneous optokinetic response produced by visual inversion. R W SperryJ Comp Physiol Psychol195014794830Yes
380121151057.579.3239.7A psychomotor stimulant theory of addiction. R A Wise, M A BozarthPsychol Rev19873317472No
380221151057.5101.5750.8Organic Photoredox Catalysis. Nathan A Romero, David A NicewiczChem Rev201627285582Yes

              Download as CSV


Copyright © 2020-2023 Solid Scientometrics Sp. z o.o.                                         Terms of Service                                                             Designed by Lukasz P. Kozlowski

All information that Unicorn Papers provides is based on PubMed data that are within the public domain. We acknowledge the NCBI, NLM, ORCID and iCite teams.