Unicorn Papers
Top ‱ cited papers from PUBMED
Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authorsCurrently, the list contains 3318 papers with ECcit ≥ 792.0
‱ - permyriad,
, literally meaning "for (every) myriad (ten thousand)"
Volume 4, December 2020
| No. | Citations | ECcit | RCR | ECRCR | Title | Authors | Journal | Year | PMID | Article(?) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 160446 | 160446.0 | 0.0 | 0.0 | Cleavage of structural proteins during the assembly of the head of bacteriophage T4. | U K Laemmli | Nature | 1970 | 5432063 | Yes |
| 2 | 129538 | 129538.0 | 0.0 | 0.0 | A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. | M M Bradford | Anal. Biochem. | 1976 | 942051 | Yes |
| 3 | 191113 | 47778.2 | 0.0 | 0.0 | Protein measurement with the Folin phenol reagent. | O H LOWRY, N J ROSEBROUGH, A L FARR, R J RANDALL | J. Biol. Chem. | 1951 | 14907713 | Yes |
| 4 | 38937 | 38937.0 | 1533.49 | 1533.5 | A short history of SHELX. | George M Sheldrick | Acta Crystallogr., A, Found. Crystallogr. | 2008 | 18156677 | Yes |
| 5 | 77028 | 38514.0 | 2205.02 | 1102.5 | Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. | K J Livak, T D Schmittgen | Methods | 2001 | 11846609 | Yes |
| 6 | 25271 | 25271.0 | 1055.67 | 1055.7 | Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. | T Mosmann | J. Immunol. Methods | 1983 | 6606682 | Yes |
| 7 | 22923 | 22923.0 | 0.0 | 0.0 | Detection of specific sequences among DNA fragments separated by gel electrophoresis. | E M Southern | J. Mol. Biol. | 1975 | 1195397 | Yes |
| 8 | 45094 | 22547.0 | 1845.92 | 923.0 | Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. | P Chomczynski, N Sacchi | Anal. Biochem. | 1987 | 2440339 | Yes |
| 9 | 21022 | 21022.0 | 520.99 | 521.0 | MicroRNAs: genomics, biogenesis, mechanism, and function. | David P Bartel | Cell | 2004 | 14744438 | No |
| 10 | 20799 | 20799.0 | 0.0 | 0.0 | The assessment and analysis of handedness: the Edinburgh inventory. | R C Oldfield | Neuropsychologia | 1971 | 5146491 | Yes |
| 11 | 18123 | 18123.0 | 472.88 | 472.9 | A new mathematical model for relative quantification in real-time RT-PCR. | M W Pfaffl | Nucleic Acids Res. | 2001 | 11328886 | Yes |
| 12 | 17992 | 17992.0 | 484.2 | 484.2 | MUSCLE: multiple sequence alignment with high accuracy and high throughput. | Robert C Edgar | Nucleic Acids Res. | 2004 | 15034147 | Yes |
| 13 | 16811 | 16811.0 | 0.0 | 0.0 | A rating scale for depression. | M HAMILTON | J. Neurol. Neurosurg. Psychiatry | 1960 | 14399272 | Yes |
| 14 | 46673 | 15557.7 | 0.0 | 0.0 | "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. | M F Folstein, S E Folstein, P R McHugh | J Psychiatr Res | 1975 | 1202204 | Yes |
| 15 | 30618 | 15309.0 | 1153.45 | 576.7 | The neighbor-joining method: a new method for reconstructing phylogenetic trees. | N Saitou, M Nei | Mol. Biol. Evol. | 1987 | 3447015 | Yes |
| 16 | 44747 | 14915.7 | 0.0 | 0.0 | DNA sequencing with chain-terminating inhibitors. | F Sanger, S Nicklen, A R Coulson | Proc. Natl. Acad. Sci. U.S.A. | 1977 | 271968 | Yes |
| 17 | 13934 | 13934.0 | 0.0 | 0.0 | The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. | E S REYNOLDS | J. Cell Biol. | 1963 | 13986422 | Yes |
| 18 | 27018 | 13509.0 | 1637.93 | 819.0 | Statistical methods for assessing agreement between two methods of clinical measurement. | J M Bland, D G Altman | Lancet | 1986 | 2868172 | Yes |
| 19 | 13358 | 13358.0 | 407.28 | 407.3 | Atherosclerosis--an inflammatory disease. | R Ross | N. Engl. J. Med. | 1999 | 9887164 | No |
| 20 | 12753 | 12753.0 | 572.0 | 572.0 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. | M Kimura | J. Mol. Evol. | 1980 | 7463489 | Yes |
| 21 | 25485 | 12742.5 | 1035.02 | 517.5 | Hallmarks of cancer: the next generation. | Douglas Hanahan, Robert A Weinberg | Cell | 2011 | 21376230 | No |
| 22 | 12660 | 12660.0 | 0.0 | 0.0 | Tissue sulfhydryl groups. | G L ELLMAN | Arch. Biochem. Biophys. | 1959 | 13650640 | Yes |
| 23 | 24955 | 12477.5 | 0.0 | 0.0 | The measurement of observer agreement for categorical data. | J R Landis, G G Koch | Biometrics | 1977 | 843571 | Yes |
| 24 | 37138 | 12379.3 | 1263.71 | 421.2 | CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. | J D Thompson, D G Higgins, T J Gibson | Nucleic Acids Res. | 1994 | 7984417 | Yes |
| 25 | 12265 | 12265.0 | 466.58 | 466.6 | CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP. | Joseph Felsenstein | Evolution | 1985 | 28561359 | Yes |
| 26 | 12232 | 12232.0 | 544.46 | 544.5 | Density-functional exchange-energy approximation with correct asymptotic behavior. | Becke | Phys Rev A Gen Phys | 1988 | 9900728 | Yes |
| 27 | 35038 | 11679.3 | 0.0 | 0.0 | Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. | H Towbin, T Staehelin, J Gordon | Proc. Natl. Acad. Sci. U.S.A. | 1979 | 388439 | Yes |
| 28 | 11605 | 11605.0 | 0.0 | 0.0 | High resolution two-dimensional electrophoresis of proteins. | P H O'Farrell | J. Biol. Chem. | 1975 | 236308 | Yes |
| 29 | 11327 | 11327.0 | 339.8 | 339.8 | MicroRNAs: target recognition and regulatory functions. | David P Bartel | Cell | 2009 | 19167326 | No |
| 30 | 21619 | 10809.5 | 0.0 | 0.0 | A rapid method of total lipid extraction and purification. | E G BLIGH, W J DYER | Can J Biochem Physiol | 1959 | 13671378 | Yes |
| 31 | 10588 | 10588.0 | 561.72 | 561.7 | A power primer. | J Cohen | Psychol Bull | 1992 | 19565683 | Yes |
| 32 | 20842 | 10421.0 | 958.25 | 479.1 | Meta-analysis in clinical trials. | R DerSimonian, N Laird | Control Clin Trials | 1986 | 3802833 | Yes |
| 33 | 10223 | 10223.0 | 0.0 | 0.0 | DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS. | B J DAVIS | Ann. N. Y. Acad. Sci. | 1964 | 14240539 | Yes |
| 34 | 20143 | 10071.5 | 1038.17 | 519.1 | The hospital anxiety and depression scale. | A S Zigmond, R P Snaith | Acta Psychiatr Scand | 1983 | 6880820 | Yes |
| 35 | 29172 | 9724.0 | 0.0 | 0.0 | A simple method for the isolation and purification of total lipides from animal tissues. | J FOLCH, M LEES, G H SLOANE STANLEY | J. Biol. Chem. | 1957 | 13428781 | Yes |
| 36 | 9712 | 9712.0 | 0.0 | 0.0 | A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. | K BURTON | Biochem. J. | 1956 | 13293190 | Yes |
| 37 | 9650 | 9650.0 | 317.06 | 317.1 | Projector augmented-wave method. | Blöchl | Phys. Rev., B Condens. Matter | 1994 | 9976227 | Yes |
| 38 | 18655 | 9327.5 | 1024.03 | 512.0 | The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. | J E Ware, C D Sherbourne | Med Care | 1992 | 1593914 | Yes |
| 39 | 9286 | 9286.0 | 439.98 | 440.0 | Structure validation in chemical crystallography. | Anthony L Spek | Acta Crystallogr. D Biol. Crystallogr. | 2009 | 19171970 | Yes |
| 40 | 18448 | 9224.0 | 444.79 | 222.4 | Coot: model-building tools for molecular graphics. | Paul Emsley, Kevin Cowtan | Acta Crystallogr. D Biol. Crystallogr. | 2004 | 15572765 | Yes |
| 41 | 8825 | 8825.0 | 439.34 | 439.3 | Catalase in vitro. | H Aebi | Meth. Enzymol. | 1984 | 6727660 | Yes |
| 42 | 43900 | 8780.0 | 1493.38 | 298.7 | Basic local alignment search tool. | S F Altschul, W Gish, W Miller, E W Myers, D J Lipman | J. Mol. Biol. | 1990 | 2231712 | Yes |
| 43 | 8660 | 8660.0 | 0.0 | 0.0 | The genetics of Caenorhabditis elegans. | S Brenner | Genetics | 1974 | 4366476 | Yes |
| 44 | 8374 | 8374.0 | 0.0 | 0.0 | Phosphorus assay in column chromatography. | G R BARTLETT | J. Biol. Chem. | 1959 | 13641241 | Yes |
| 45 | 25002 | 8334.0 | 889.61 | 296.5 | Generalized Gradient Approximation Made Simple. | Perdew, Burke, Ernzerhof | Phys. Rev. Lett. | 1996 | 10062328 | Yes |
| 46 | 16550 | 8275.0 | 495.12 | 247.6 | Fast and accurate short read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2009 | 19451168 | Yes |
| 47 | 8177 | 8177.0 | 281.42 | 281.4 | The Psychophysics Toolbox. | D H Brainard | Spat Vis | 1997 | 9176952 | Yes |
| 48 | 7800 | 7800.0 | 253.49 | 253.5 | XDS. | Wolfgang Kabsch | Acta Crystallogr. D Biol. Crystallogr. | 2010 | 20124692 | Yes |
| 49 | 7789 | 7789.0 | 330.01 | 330.0 | Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). | J F Kurtzke | Neurology | 1983 | 6685237 | Yes |
| 50 | 7778 | 7778.0 | 318.05 | 318.1 | Search and clustering orders of magnitude faster than BLAST. | Robert C Edgar | Bioinformatics | 2010 | 20709691 | Yes |
| 51 | 15515 | 7757.5 | 580.55 | 290.3 | A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. | A P Feinberg, B Vogelstein | Anal. Biochem. | 1983 | 6312838 | Yes |
| 52 | 7660 | 7660.0 | 492.64 | 492.6 | RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. | Alexandros Stamatakis | Bioinformatics | 2014 | 24451623 | Yes |
| 53 | 15236 | 7618.0 | 373.45 | 186.7 | [20] Processing of X-ray diffraction data collected in oscillation mode. | Zbyszek Otwinowski, Wladek Minor | Meth. Enzymol. | 1997 | 27799103 | Yes |
| 54 | 7556 | 7556.0 | 180.7 | 180.7 | Mfold web server for nucleic acid folding and hybridization prediction. | Michael Zuker | Nucleic Acids Res. | 2003 | 12824337 | Yes |
| 55 | 7540 | 7540.0 | 265.09 | 265.1 | Studies on transformation of Escherichia coli with plasmids. | D Hanahan | J. Mol. Biol. | 1983 | 6345791 | Yes |
| 56 | 7512 | 7512.0 | 170.96 | 171.0 | Linear models and empirical bayes methods for assessing differential expression in microarray experiments. | Gordon K Smyth | Stat Appl Genet Mol Biol | 2004 | 16646809 | Yes |
| 57 | 7454 | 7454.0 | 0.0 | 0.0 | Self-efficacy: toward a unifying theory of behavioral change. | A Bandura | Psychol Rev | 1977 | 847061 | Yes |
| 58 | 22265 | 7421.7 | 1015.93 | 338.6 | Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. | Lee, Yang, Parr | Phys. Rev., B Condens. Matter | 1988 | 9944570 | Yes |
| 59 | 14647 | 7323.5 | 799.66 | 399.8 | The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. | R M Baron, D A Kenny | J Pers Soc Psychol | 1986 | 3806354 | Yes |
| 60 | 7318 | 7318.0 | 219.5 | 219.5 | RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. | Alexandros Stamatakis | Bioinformatics | 2006 | 16928733 | Yes |
| 61 | 7275 | 7275.0 | 252.1 | 252.1 | Evolutionary trees from DNA sequences: a maximum likelihood approach. | J Felsenstein | J. Mol. Evol. | 1981 | 7288891 | Yes |
| 62 | 7221 | 7221.0 | 347.26 | 347.3 | A new method for measuring daytime sleepiness: the Epworth sleepiness scale. | M W Johns | Sleep | 1991 | 1798888 | Yes |
| 63 | 14376 | 7188.0 | 346.96 | 173.5 | The hallmarks of cancer. | D Hanahan, R A Weinberg | Cell | 2000 | 10647931 | No |
| 64 | 7067 | 7067.0 | 261.65 | 261.6 | The pathogenesis of atherosclerosis: a perspective for the 1990s. | R Ross | Nature | 1993 | 8479518 | No |
| 65 | 14098 | 7049.0 | 493.44 | 246.7 | A simple method for displaying the hydropathic character of a protein. | J Kyte, R F Doolittle | J. Mol. Biol. | 1982 | 7108955 | Yes |
| 66 | 13873 | 6936.5 | 577.38 | 288.7 | Fast gapped-read alignment with Bowtie 2. | Ben Langmead, Steven L Salzberg | Nat. Methods | 2012 | 22388286 | Yes |
| 67 | 13704 | 6852.0 | 454.56 | 227.3 | Quantifying heterogeneity in a meta-analysis. | Julian P T Higgins, Simon G Thompson | Stat Med | 2002 | 12111919 | Yes |
| 68 | 6844 | 6844.0 | 247.89 | 247.9 | Vitamin D deficiency. | Michael F Holick | N. Engl. J. Med. | 2007 | 17634462 | No |
| 69 | 6756 | 6756.0 | 0.0 | 0.0 | Improvements in epoxy resin embedding methods. | J H LUFT | J Biophys Biochem Cytol | 1961 | 13764136 | Yes |
| 70 | 6538 | 6538.0 | 220.65 | 220.7 | Integrins: versatility, modulation, and signaling in cell adhesion. | R O Hynes | Cell | 1992 | 1555235 | No |
| 71 | 6536 | 6536.0 | 153.87 | 153.9 | The functions of animal microRNAs. | Victor Ambros | Nature | 2004 | 15372042 | No |
| 72 | 12872 | 6436.0 | 0.0 | 0.0 | The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. | K Weber, M Osborn | J. Biol. Chem. | 1969 | 5806584 | Yes |
| 73 | 6417 | 6417.0 | 277.08 | 277.1 | Banting lecture 1988. Role of insulin resistance in human disease. | G M Reaven | Diabetes | 1988 | 3056758 | No |
| 74 | 6402 | 6402.0 | 370.11 | 370.1 | Psychophysical bases of perceived exertion. | G A Borg | Med Sci Sports Exerc | 1982 | 7154893 | Yes |
| 75 | 12668 | 6334.0 | 318.16 | 159.1 | Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. | Kazutoshi Takahashi, Shinya Yamanaka | Cell | 2006 | 16904174 | Yes |
| 76 | 6290 | 6290.0 | 0.0 | 0.0 | On the origin of cancer cells. | O WARBURG | Science | 1956 | 13298683 | Yes |
| 77 | 24744 | 6186.0 | 879.55 | 219.9 | Measuring inconsistency in meta-analyses. | Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman | BMJ | 2003 | 12958120 | No |
| 78 | 12361 | 6180.5 | 394.32 | 197.2 | Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. | Kresse, Furthmüller | Phys. Rev., B Condens. Matter | 1996 | 9984901 | Yes |
| 79 | 6171 | 6171.0 | 190.82 | 190.8 | Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. | M C Hochberg | Arthritis Rheum. | 1997 | 9324032 | Yes |
| 80 | 6166 | 6166.0 | 574.44 | 574.4 | Crystal structure refinement with SHELXL. | George M Sheldrick | Acta Crystallogr C Struct Chem | 2015 | 25567568 | Yes |
| 81 | 12285 | 6142.5 | 345.6 | 172.8 | MrBayes 3: Bayesian phylogenetic inference under mixed models. | Fredrik Ronquist, John P Huelsenbeck | Bioinformatics | 2003 | 12912839 | Yes |
| 82 | 6130 | 6130.0 | 199.74 | 199.7 | TreeView: an application to display phylogenetic trees on personal computers. | R D Page | Comput. Appl. Biosci. | 1996 | 8902363 | Yes |
| 83 | 6118 | 6118.0 | 0.0 | 0.0 | COPPER ENZYMES IN ISOLATED CHLOROPLASTS. POLYPHENOLOXIDASE IN BETA VULGARIS. | D I Arnon | Plant Physiol. | 1949 | 16654194 | Yes |
| 84 | 42449 | 6064.1 | 1261.38 | 180.2 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. | S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J Lipman | Nucleic Acids Res. | 1997 | 9254694 | No |
| 85 | 6060 | 6060.0 | 185.1 | 185.1 | Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. | F Tajima | Genetics | 1989 | 2513255 | Yes |
| 86 | 18168 | 6056.0 | 560.08 | 186.7 | Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nat Protoc | 2009 | 19131956 | Yes |
| 87 | 17854 | 5951.3 | 521.76 | 173.9 | VMD: visual molecular dynamics. | W Humphrey, A Dalke, K Schulten | J Mol Graph | 1996 | 8744570 | Yes |
| 88 | 5906 | 5906.0 | 199.62 | 199.6 | Semiempirical GGA-type density functional constructed with a long-range dispersion correction. | Stefan Grimme | J Comput Chem | 2006 | 16955487 | Yes |
| 89 | 5896 | 5896.0 | 200.11 | 200.1 | AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. | R W Cox | Comput. Biomed. Res. | 1996 | 8812068 | Yes |
| 90 | 23261 | 5815.2 | 1067.56 | 266.9 | A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. | M E Charlson, P Pompei, K L Ales, C R MacKenzie | J Chronic Dis | 1987 | 3558716 | Yes |
| 91 | 5812 | 5812.0 | 242.56 | 242.6 | Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. | P S Thomas | Proc. Natl. Acad. Sci. U.S.A. | 1980 | 6159641 | Yes |
| 92 | 11579 | 5789.5 | 280.45 | 140.2 | Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. | S J Clough, A F Bent | Plant J. | 1998 | 10069079 | Yes |
| 93 | 5781 | 5781.0 | 141.98 | 142.0 | Chromatin modifications and their function. | Tony Kouzarides | Cell | 2007 | 17320507 | No |
| 94 | 5674 | 5674.0 | 159.5 | 159.5 | PAML 4: phylogenetic analysis by maximum likelihood. | Ziheng Yang | Mol. Biol. Evol. | 2007 | 17483113 | Yes |
| 95 | 5585 | 5585.0 | 221.93 | 221.9 | "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. | W N Burnette | Anal. Biochem. | 1981 | 6266278 | Yes |
| 96 | 22056 | 5514.0 | 858.48 | 214.6 | Bias in meta-analysis detected by a simple, graphical test. | M Egger, G Davey Smith, M Schneider, C Minder | BMJ | 1997 | 9310563 | Yes |
| 97 | 5507 | 5507.0 | 0.0 | 0.0 | A simplification of the protein assay method of Lowry et al. which is more generally applicable. | G L Peterson | Anal. Biochem. | 1977 | 603028 | Yes |
| 98 | 5461 | 5461.0 | 159.95 | 159.9 | Fast robust automated brain extraction. | Stephen M Smith | Hum Brain Mapp | 2002 | 12391568 | No |
| 99 | 10873 | 5436.5 | 339.48 | 169.7 | Analyzing real-time PCR data by the comparative C(T) method. | Thomas D Schmittgen, Kenneth J Livak | Nat Protoc | 2008 | 18546601 | Yes |
| 100 | 5428 | 5428.0 | 0.0 | 0.0 | Solvent content of protein crystals. | B W Matthews | J. Mol. Biol. | 1968 | 5700707 | Yes |
| 101 | 5405 | 5405.0 | 187.45 | 187.4 | The VideoToolbox software for visual psychophysics: transforming numbers into movies. | D G Pelli | Spat Vis | 1997 | 9176953 | Yes |
| 102 | 10693 | 5346.5 | 413.49 | 206.7 | Sequencing end-labeled DNA with base-specific chemical cleavages. | A M Maxam, W Gilbert | Meth. Enzymol. | 1980 | 6246368 | Yes |
| 103 | 5218 | 5218.0 | 218.82 | 218.8 | Ethical guidelines for investigations of experimental pain in conscious animals. | M Zimmermann | Pain | 1983 | 6877845 | No |
| 104 | 5208 | 5208.0 | 0.0 | 0.0 | A low-viscosity epoxy resin embedding medium for electron microscopy. | A R Spurr | J. Ultrastruct. Res. | 1969 | 4887011 | Yes |
| 105 | 15466 | 5155.3 | 0.0 | 0.0 | Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. | W T Friedewald, R I Levy, D S Fredrickson | Clin. Chem. | 1972 | 4337382 | Yes |
| 106 | 5127 | 5127.0 | 316.12 | 316.1 | Comparative fit indexes in structural models. | P M Bentler | Psychol Bull | 1990 | 2320703 | Yes |
| 107 | 15257 | 5085.7 | 577.29 | 192.4 | A new generation of Ca2+ indicators with greatly improved fluorescence properties. | G Grynkiewicz, M Poenie, R Y Tsien | J. Biol. Chem. | 1985 | 3838314 | Yes |
| 108 | 5059 | 5059.0 | 0.0 | 0.0 | Evaluation of survival data and two new rank order statistics arising in its consideration. | N Mantel | Cancer Chemother Rep | 1966 | 5910392 | Yes |
| 109 | 15143 | 5047.7 | 684.18 | 228.1 | NIH Image to ImageJ: 25 years of image analysis. | Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri | Nat. Methods | 2012 | 22930834 | No |
| 110 | 5046 | 5046.0 | 169.09 | 169.1 | Canonical dynamics: Equilibrium phase-space distributions. | Hoover | Phys Rev A Gen Phys | 1985 | 9895674 | Yes |
| 111 | 4985 | 4985.0 | 194.76 | 194.8 | The blockade of immune checkpoints in cancer immunotherapy. | Drew M Pardoll | Nat. Rev. Cancer | 2012 | 22437870 | No |
| 112 | 4970 | 4970.0 | 203.94 | 203.9 | The role of protein kinase C in cell surface signal transduction and tumour promotion. | Y Nishizuka | Nature | 1984 | 6232463 | No |
| 113 | 4963 | 4963.0 | 113.1 | 113.1 | Integrins: bidirectional, allosteric signaling machines. | Richard O Hynes | Cell | 2002 | 12297042 | No |
| 114 | 4877 | 4877.0 | 212.1 | 212.1 | Density-functional approximation for the correlation energy of the inhomogeneous electron gas. | Perdew | Phys. Rev., B Condens. Matter | 1986 | 9938299 | Yes |
| 115 | 9746 | 4873.0 | 0.0 | 0.0 | A rapid alkaline extraction procedure for screening recombinant plasmid DNA. | H C Birnboim, J Doly | Nucleic Acids Res. | 1979 | 388356 | Yes |
| 116 | 4870 | 4870.0 | 126.36 | 126.4 | Inflammation in atherosclerosis. | Peter Libby | Nature | 2002 | 12490960 | No |
| 117 | 4869 | 4869.0 | 0.0 | 0.0 | Tumor angiogenesis: therapeutic implications. | J Folkman | N. Engl. J. Med. | 1971 | 4938153 | No |
| 118 | 4868 | 4868.0 | 152.66 | 152.7 | Angiogenesis in cancer, vascular, rheumatoid and other disease. | J Folkman | Nat. Med. | 1995 | 7584949 | No |
| 119 | 4787 | 4787.0 | 190.18 | 190.2 | The Clinical Dementia Rating (CDR): current version and scoring rules. | J C Morris | Neurology | 1993 | 8232972 | Yes |
| 120 | 4781 | 4781.0 | 118.62 | 118.6 | p53, the cellular gatekeeper for growth and division. | A J Levine | Cell | 1997 | 9039259 | No |
| 121 | 4770 | 4770.0 | 134.52 | 134.5 | Inflammation, atherosclerosis, and coronary artery disease. | Göran K Hansson | N. Engl. J. Med. | 2005 | 15843671 | No |
| 122 | 4755 | 4755.0 | 0.0 | 0.0 | Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. | J R Vane | Nature New Biol. | 1971 | 5284360 | Yes |
| 123 | 9510 | 4755.0 | 219.28 | 109.6 | KEGG: kyoto encyclopedia of genes and genomes. | M Kanehisa, S Goto | Nucleic Acids Res. | 2000 | 10592173 | Yes |
| 124 | 9403 | 4701.5 | 0.0 | 0.0 | Intraclass correlations: uses in assessing rater reliability. | P E Shrout, J L Fleiss | Psychol Bull | 1979 | 18839484 | No |
| 125 | 4680 | 4680.0 | 213.73 | 213.7 | Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. | Andreas Stang | Eur. J. Epidemiol. | 2010 | 20652370 | Yes |
| 126 | 4673 | 4673.0 | 132.0 | 132.0 | Biochemistry and molecular cell biology of diabetic complications. | M Brownlee | Nature | 2001 | 11742414 | Yes |
| 127 | 9344 | 4672.0 | 307.89 | 153.9 | MODELTEST: testing the model of DNA substitution. | D Posada, K A Crandall | Bioinformatics | 1998 | 9918953 | Yes |
| 128 | 9341 | 4670.5 | 250.24 | 125.1 | A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. | Stéphane Guindon, Olivier Gascuel | Syst. Biol. | 2003 | 14530136 | Yes |
| 129 | 4650 | 4650.0 | 0.0 | 0.0 | Development of a rating scale for primary depressive illness. | M Hamilton | Br J Soc Clin Psychol | 1967 | 6080235 | Yes |
| 130 | 9284 | 4642.0 | 260.01 | 130.0 | MRBAYES: Bayesian inference of phylogenetic trees. | J P Huelsenbeck, F Ronquist | Bioinformatics | 2001 | 11524383 | Yes |
| 131 | 9267 | 4633.5 | 237.26 | 118.6 | Dendritic cells and the control of immunity. | J Banchereau, R M Steinman | Nature | 1998 | 9521319 | No |
| 132 | 18531 | 4632.8 | 923.07 | 230.8 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | PLoS Med. | 2009 | 19621072 | No |
| 133 | 9169 | 4584.5 | 0.0 | 0.0 | Statistical aspects of the analysis of data from retrospective studies of disease. | N MANTEL, W HAENSZEL | J. Natl. Cancer Inst. | 1959 | 13655060 | Yes |
| 134 | 4584 | 4584.0 | 93.82 | 93.8 | BLAT--the BLAST-like alignment tool. | W James Kent | Genome Res. | 2002 | 11932250 | Yes |
| 135 | 4579 | 4579.0 | 142.97 | 143.0 | Apoptosis: a review of programmed cell death. | Susan Elmore | Toxicol Pathol | 2007 | 17562483 | No |
| 136 | 22861 | 4572.2 | 724.04 | 144.8 | The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. | J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G Higgins | Nucleic Acids Res. | 1997 | 9396791 | Yes |
| 137 | 9121 | 4560.5 | 0.0 | 0.0 | Prediction of creatinine clearance from serum creatinine. | D W Cockcroft, M H Gault | Nephron | 1976 | 1244564 | Yes |
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