Unicorn Papers - Top cited papers from PUBMED

No.	Citations	EC_cit	RCR	EC_RCR	Title	Authors	Journal	Year	PMID	Article(?)
1	223478	223478.0	0.0	0.0	Cleavage of structural proteins during the assembly of the head of bacteriophage T4.	U K Laemmli	Nature	1970	5432063	Yes
2	171401	171401.0	0.0	0.0	A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.	M M Bradford	Anal Biochem	1976	942051	Yes
3	283539	70884.8	0.0	0.0	Protein measurement with the Folin phenol reagent.	O H Lowry, N J Rosebrough, A L Farr, R J Randall	J Biol Chem	1951	14907713	Yes
4	111470	55735.0	2798.67	1399.3	Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.	K J Livak, T D Schmittgen	Methods	2001	11846609	Yes
5	44518	44518.0	1416.44	1416.4	A short history of SHELX.	George M Sheldrick	Acta Crystallogr A	2008	18156677	Yes
6	35553	35553.0	1146.02	1146.0	Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.	T Mosmann	J Immunol Methods	1983	6606682	Yes
7	65191	32595.5	1963.96	982.0	Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.	P Chomczynski, N Sacchi	Anal Biochem	1987	2440339	Yes
8	30225	30225.0	0.0	0.0	Detection of specific sequences among DNA fragments separated by gel electrophoresis.	E M Southern	J Mol Biol	1975	1195397	Yes
9	26963	26963.0	0.0	0.0	The assessment and analysis of handedness: the Edinburgh inventory.	R C Oldfield	Neuropsychologia	1971	5146491	Yes
10	26779	26779.0	601.46	601.5	MicroRNAs: genomics, biogenesis, mechanism, and function.	David P Bartel	Cell	2004	14744438	No
11	24894	24894.0	0.0	0.0	A rating scale for depression.	M Hamilton	J Neurol Neurosurg Psychiatry	1960	14399272	Yes
12	24386	24386.0	586.76	586.8	MUSCLE: multiple sequence alignment with high accuracy and high throughput.	Robert C Edgar	Nucleic Acids Res	2004	15034147	Yes
13	23632	23632.0	736.7	736.7	Confidence Limits On Phylogenies: An Approach Using The Bootstrap.	Joseph Felsenstein	Evolution	1985	28561359	Yes
14	23299	23299.0	540.47	540.5	A new mathematical model for relative quantification in real-time RT-PCR.	M W Pfaffl	Nucleic Acids Res	2001	11328886	Yes
15	65737	21912.3	0.0	0.0	DNA sequencing with chain-terminating inhibitors.	F Sanger, S Nicklen, A R Coulson	Proc Natl Acad Sci U S A	1977	271968	Yes
16	63916	21305.3	0.0	0.0	"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician.	M F Folstein, S E Folstein, P R McHugh	J Psychiatr Res	1975	1202204	Yes
17	20155	20155.0	0.0	0.0	The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.	E S Reynolds	J Cell Biol	1963	13986422	Yes
18	19760	19760.0	689.63	689.6	Density-functional exchange-energy approximation with correct asymptotic behavior.	Becke	Phys Rev A Gen Phys	1988	9900728	Yes
19	38614	19307.0	1266.41	633.2	Hallmarks of cancer: the next generation.	Douglas Hanahan, Robert A Weinberg	Cell	2011	21376230	No
20	38609	19304.5	1193.16	596.6	The neighbor-joining method: a new method for reconstructing phylogenetic trees.	N Saitou, M Nei	Mol Biol Evol	1987	3447015	Yes
21	18987	18987.0	0.0	0.0	Tissue sulfhydryl groups.	G L Ellman	Arch Biochem Biophys	1959	13650640	Yes
22	53373	17791.0	0.0	0.0	Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.	H Towbin, T Staehelin, J Gordon	Proc Natl Acad Sci U S A	1979	388439	Yes
23	34433	17216.5	1644.05	822.0	Statistical methods for assessing agreement between two methods of clinical measurement.	J M Bland, D G Altman	Lancet	1986	2868172	Yes
24	16825	16825.0	0.0	0.0	Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins.	B J Davis	Ann N Y Acad Sci	1964	14240539	Yes
25	16629	16629.0	423.14	423.1	Atherosclerosis--an inflammatory disease.	R Ross	N Engl J Med	1999	9887164	No
26	16395	16395.0	603.91	603.9	A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences.	M Kimura	J Mol Evol	1980	7463489	Yes
27	16151	16151.0	0.0	0.0	High resolution two-dimensional electrophoresis of proteins.	P H O'Farrell	J Biol Chem	1975	236308	Yes
28	16091	16091.0	460.64	460.6	Projector augmented-wave method.	Blöchl	Phys Rev B Condens Matter	1994	9976227	Yes
29	15915	15915.0	0.0	0.0	A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.	K Burton	Biochem J	1956	13293190	Yes
30	31620	15810.0	0.0	0.0	The measurement of observer agreement for categorical data.	J R Landis, G G Koch	Biometrics	1977	843571	Yes
31	31434	15717.0	0.0	0.0	A rapid method of total lipid extraction and purification.	E G Bligh, W J Dyer	Can J Biochem Physiol	1959	13671378	Yes
32	44607	14869.0	1277.57	425.9	CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.	J D Thompson, D G Higgins, T J Gibson	Nucleic Acids Res	1994	7984417	Yes
33	14729	14729.0	384.23	384.2	MicroRNAs: target recognition and regulatory functions.	David P Bartel	Cell	2009	19167326	No
34	14673	14673.0	677.39	677.4	RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies.	Alexandros Stamatakis	Bioinformatics	2014	24451623	Yes
35	14314	14314.0	595.86	595.9	A power primer.	J Cohen	Psychol Bull	1992	19565683	Yes
36	28025	14012.5	1060.06	530.0	Meta-analysis in clinical trials.	R DerSimonian, N Laird	Control Clin Trials	1986	3802833	Yes
37	27950	13975.0	1131.07	565.5	The hospital anxiety and depression scale.	A S Zigmond, R P Snaith	Acta Psychiatr Scand	1983	6880820	Yes
38	40765	13588.3	1233.66	411.2	Generalized Gradient Approximation Made Simple.	Perdew, Burke, Ernzerhof	Phys Rev Lett	1996	10062328	Yes
39	40662	13554.0	0.0	0.0	A simple method for the isolation and purification of total lipides from animal tissues.	J Folch, M Lees, G H Sloane Stanley	J Biol Chem	1957	13428781	Yes
40	13413	13413.0	526.68	526.7	Catalase in vitro.	H Aebi	Methods Enzymol	1984	6727660	Yes
41	25520	12760.0	670.83	335.4	Fast and accurate short read alignment with Burrows-Wheeler transform.	Heng Li, Richard Durbin	Bioinformatics	2009	19451168	Yes
42	12585	12585.0	0.0	0.0	Phosphorus assay in column chromatography.	G R Bartlett	J Biol Chem	1959	13641241	Yes
43	25123	12561.5	847.44	423.7	Fast gapped-read alignment with Bowtie 2.	Ben Langmead, Steven L Salzberg	Nat Methods	2012	22388286	Yes
44	59667	11933.4	1717.52	343.5	Basic local alignment search tool.	S F Altschul, W Gish, W Miller, E W Myers, D J Lipman	J Mol Biol	1990	2231712	Yes
45	11732	11732.0	671.48	671.5	Crystal structure refinement with SHELXL.	George M Sheldrick	Acta Crystallogr C Struct Chem	2015	25567568	Yes
46	35143	11714.3	1263.07	421.0	Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density.	Lee, Yang, Parr	Phys Rev B Condens Matter	1988	9944570	Yes
47	23331	11665.5	494.31	247.2	Coot: model-building tools for molecular graphics.	Paul Emsley, Kevin Cowtan	Acta Crystallogr D Biol Crystallogr	2004	15572765	Yes
48	23183	11591.5	962.7	481.4	The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection.	J E Ware, C D Sherbourne	Med Care	1992	1593914	Yes
49	11480	11480.0	388.75	388.8	Search and clustering orders of magnitude faster than BLAST.	Robert C Edgar	Bioinformatics	2010	20709691	Yes
50	11198	11198.0	371.02	371.0	Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS).	J F Kurtzke	Neurology	1983	6685237	Yes
51	11088	11088.0	297.73	297.7	Xds.	Wolfgang Kabsch	Acta Crystallogr D Biol Crystallogr	2010	20124692	Yes
52	10957	10957.0	0.0	0.0	The genetics of Caenorhabditis elegans.	S Brenner	Genetics	1974	4366476	Yes
53	21569	10784.5	558.81	279.4	A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.	A P Feinberg, B Vogelstein	Anal Biochem	1983	6312838	Yes
54	10757	10757.0	327.38	327.4	The Psychophysics Toolbox.	D H Brainard	Spat Vis	1997	9176952	Yes
55	32188	10729.3	1280.23	426.7	Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.	Michael I Love, Wolfgang Huber, Simon Anders	Genome Biol	2014	25516281	Yes
56	10587	10587.0	0.0	0.0	Self-efficacy: toward a unifying theory of behavioral change.	A Bandura	Psychol Rev	1977	847061	Yes
57	21031	10515.5	592.16	296.1	Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set.	Kresse, Furthmüller	Phys Rev B Condens Matter	1996	9984901	Yes
58	20775	10387.5	458.12	229.1	[20] Processing of X-ray diffraction data collected in oscillation mode.	Zbyszek Otwinowski, Wladek Minor	Methods Enzymol	1997	27799103	Yes
59	10362	10362.0	375.69	375.7	Structure validation in chemical crystallography.	Anthony L Spek	Acta Crystallogr D Biol Crystallogr	2009	19171970	Yes
60	10343	10343.0	0.0	0.0	Improvements in epoxy resin embedding methods.	J H Luft	J Biophys Biochem Cytol	1961	13764136	Yes
61	20560	10280.0	563.22	281.6	Quantifying heterogeneity in a meta-analysis.	Julian P T Higgins, Simon G Thompson	Stat Med	2002	12111919	Yes
62	10200	10200.0	394.27	394.3	A new method for measuring daytime sleepiness: the Epworth sleepiness scale.	M W Johns	Sleep	1991	1798888	Yes
63	19771	9885.5	0.0	0.0	The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.	K Weber, M Osborn	J Biol Chem	1969	5806584	Yes
64	19280	9640.0	848.99	424.5	The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations.	R M Baron, D A Kenny	J Pers Soc Psychol	1986	3806354	Yes
65	9525	9525.0	321.44	321.4	Banting lecture 1988. Role of insulin resistance in human disease.	G M Reaven	Diabetes	1988	3056758	No
66	28389	9463.0	746.93	249.0	VMD: visual molecular dynamics.	W Humphrey, A Dalke, K Schulten	J Mol Graph	1996	8744570	Yes
67	37623	9405.8	1517.26	379.3	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	PLoS Med	2009	19621072	No
68	18640	9320.0	485.56	242.8	A simple method for displaying the hydropathic character of a protein.	J Kyte, R F Doolittle	J Mol Biol	1982	7108955	Yes
69	9281	9281.0	0.0	0.0	On the origin of cancer cells.	O Warburg	Science	1956	13298683	Yes
70	9256	9256.0	265.01	265.0	Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.	P S Thomas	Proc Natl Acad Sci U S A	1980	6159641	Yes
71	9247	9247.0	244.93	244.9	Studies on transformation of Escherichia coli with plasmids.	D Hanahan	J Mol Biol	1983	6345791	Yes
72	36982	9245.5	1076.28	269.1	Measuring inconsistency in meta-analyses.	Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman	BMJ	2003	12958120	No
73	9172	9172.0	259.81	259.8	Evolutionary trees from DNA sequences: a maximum likelihood approach.	J Felsenstein	J Mol Evol	1981	7288891	Yes
74	9140	9140.0	260.22	260.2	The pathogenesis of atherosclerosis: a perspective for the 1990s.	R Ross	Nature	1993	8479518	No
75	9132	9132.0	194.33	194.3	Mfold web server for nucleic acid folding and hybridization prediction.	Michael Zuker	Nucleic Acids Res	2003	12824337	Yes
76	9069	9069.0	330.81	330.8	Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses.	Andreas Stang	Eur J Epidemiol	2010	20652370	Yes
77	9025	9025.0	234.82	234.8	Integrins: versatility, modulation, and signaling in cell adhesion.	R O Hynes	Cell	1992	1555235	No
78	8959	8959.0	237.8	237.8	RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models.	Alexandros Stamatakis	Bioinformatics	2006	16928733	Yes
79	8928	8928.0	266.12	266.1	Vitamin D deficiency.	Michael F Holick	N Engl J Med	2007	17634462	No
80	17528	8764.0	374.29	187.1	The hallmarks of cancer.	D Hanahan, R A Weinberg	Cell	2000	10647931	No
81	26265	8755.0	938.31	312.8	NIH Image to ImageJ: 25 years of image analysis.	Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri	Nat Methods	2012	22930834	No
82	26241	8747.0	1113.2	371.1	Trimmomatic: a flexible trimmer for Illumina sequence data.	Anthony M Bolger, Marc Lohse, Bjoern Usadel	Bioinformatics	2014	24695404	Yes
83	8726	8726.0	241.35	241.3	Semiempirical GGA-type density functional constructed with a long-range dispersion correction.	Stefan Grimme	J Comput Chem	2006	16955487	Yes
84	8617	8617.0	371.44	371.4	Investigation of the freely available easy-to-use software 'EZR' for medical statistics.	Y Kanda	Bone Marrow Transplant	2013	23208313	Yes
85	8578	8578.0	376.01	376.0	Psychophysical bases of perceived exertion.	G A Borg	Med Sci Sports Exerc	1982	7154893	Yes
86	8564	8564.0	177.18	177.2	Linear models and empirical bayes methods for assessing differential expression in microarray experiments.	Gordon K Smyth	Stat Appl Genet Mol Biol	2004	16646809	Yes
87	17100	8550.0	703.02	351.5	MAFFT multiple sequence alignment software version 7: improvements in performance and usability.	Kazutaka Katoh, Daron M Standley	Mol Biol Evol	2013	23329690	Yes
88	33505	8376.2	1248.82	312.2	A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.	M E Charlson, P Pompei, K L Ales, C R MacKenzie	J Chronic Dis	1987	3558716	Yes
89	8294	8294.0	178.89	178.9	The functions of animal microRNAs.	Victor Ambros	Nature	2004	15372042	No
90	8254	8254.0	256.8	256.8	The blockade of immune checkpoints in cancer immunotherapy.	Drew M Pardoll	Nat Rev Cancer	2012	22437870	No
91	24718	8239.3	658.93	219.6	Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.	Da Wei Huang, Brad T Sherman, Richard A Lempicki	Nat Protoc	2009	19131956	Yes
92	16452	8226.0	359.1	179.6	KEGG: kyoto encyclopedia of genes and genomes.	M Kanehisa, S Goto	Nucleic Acids Res	2000	10592173	Yes
93	8189	8189.0	216.17	216.2	Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.	M C Hochberg	Arthritis Rheum	1997	9324032	Yes
94	8122	8122.0	0.0	0.0	Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris.	D I Arnon	Plant Physiol	1949	16654194	Yes
95	16185	8092.5	366.11	183.1	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.	Kazutoshi Takahashi, Shinya Yamanaka	Cell	2006	16904174	Yes
96	8042	8042.0	0.0	0.0	Solvent content of protein crystals.	B W Matthews	J Mol Biol	1968	5700707	Yes
97	31919	7979.8	1042.28	260.6	Bias in meta-analysis detected by a simple, graphical test.	M Egger, G Davey Smith, M Schneider, C Minder	BMJ	1997	9310563	Yes
98	15855	7927.5	431.18	215.6	Analyzing real-time PCR data by the comparative C(T) method.	Thomas D Schmittgen, Kenneth J Livak	Nat Protoc	2008	18546601	Yes
99	7826	7826.0	218.17	218.2	"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.	W N Burnette	Anal Biochem	1981	6266278	Yes
100	7795	7795.0	216.69	216.7	The role of protein kinase C in cell surface signal transduction and tumour promotion.	Y Nishizuka	Nature	1984	6232463	No
101	7789	7789.0	193.38	193.4	PAML 4: phylogenetic analysis by maximum likelihood.	Ziheng Yang	Mol Biol Evol	2007	17483113	Yes
102	7783	7783.0	208.93	208.9	Canonical dynamics: Equilibrium phase-space distributions.	Hoover	Phys Rev A Gen Phys	1985	9895674	Yes
103	7757	7757.0	0.0	0.0	A simplification of the protein assay method of Lowry et al. which is more generally applicable.	G L Peterson	Anal Biochem	1977	603028	Yes
104	7629	7629.0	0.0	0.0	Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.	J R Vane	Nat New Biol	1971	5284360	Yes
105	7558	7558.0	225.29	225.3	AFNI: software for analysis and visualization of functional magnetic resonance neuroimages.	R W Cox	Comput Biomed Res	1996	8812068	Yes
106	45292	7548.7	3645.81	607.6	Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.	Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal	CA Cancer J Clin	2018	30207593	Yes
107	14955	7477.5	369.52	184.8	MrBayes 3: Bayesian phylogenetic inference under mixed models.	Fredrik Ronquist, John P Huelsenbeck	Bioinformatics	2003	12912839	Yes
108	7455	7455.0	0.0	0.0	Tumor angiogenesis: therapeutic implications.	J Folkman	N Engl J Med	1971	4938153	No
109	14895	7447.5	316.04	158.0	Processing of X-ray diffraction data collected in oscillation mode.	Z Otwinowski, W Minor	Methods Enzymol	1997	27754618	Yes
110	7396	7396.0	199.97	200.0	Apoptosis: a review of programmed cell death.	Susan Elmore	Toxicol Pathol	2007	17562483	No
111	7370	7370.0	345.17	345.2	Comparative fit indexes in structural models.	P M Bentler	Psychol Bull	1990	2320703	Yes
112	7333	7333.0	362.31	362.3	Prokka: rapid prokaryotic genome annotation.	Torsten Seemann	Bioinformatics	2014	24642063	Yes
113	7310	7310.0	0.0	0.0	A low-viscosity epoxy resin embedding medium for electron microscopy.	A R Spurr	J Ultrastruct Res	1969	4887011	Yes
114	21919	7306.3	1378.91	459.6	MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets.	Sudhir Kumar, Glen Stecher, Koichiro Tamura	Mol Biol Evol	2016	27004904	Yes
115	7293	7293.0	244.97	245.0	Density-functional approximation for the correlation energy of the inhomogeneous electron gas.	Perdew	Phys Rev B Condens Matter	1986	9938299	Yes
116	7218	7218.0	194.3	194.3	Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.	F Tajima	Genetics	1989	2513255	Yes
117	50312	7187.4	1310.09	187.2	Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.	S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J Lipman	Nucleic Acids Res	1997	9254694	No
118	14366	7183.0	326.76	163.4	Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana.	S J Clough, A F Bent	Plant J	1998	10069079	Yes
119	7173	7173.0	157.85	157.8	Chromatin modifications and their function.	Tony Kouzarides	Cell	2007	17320507	No
120	21476	7158.7	0.0	0.0	Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.	W T Friedewald, R I Levy, D S Fredrickson	Clin Chem	1972	4337382	Yes
121	7115	7115.0	325.14	325.1	UPARSE: highly accurate OTU sequences from microbial amplicon reads.	Robert C Edgar	Nat Methods	2013	23955772	Yes
122	7098	7098.0	178.28	178.3	Fast robust automated brain extraction.	Stephen M Smith	Hum Brain Mapp	2002	12391568	No
123	7047	7047.0	192.74	192.7	TreeView: an application to display phylogenetic trees on personal computers.	R D Page	Comput Appl Biosci	1996	8902363	Yes
124	6997	6997.0	0.0	0.0	The assessment of anxiety states by rating.	M Hamilton	Br J Med Psychol	1959	13638508	Yes
125	6988	6988.0	0.0	0.0	Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.	A Böyum	Scand J Clin Lab Invest Suppl	1968	4179068	Yes
126	6876	6876.0	381.86	381.9	SHELXT - integrated space-group and crystal-structure determination.	George M Sheldrick	Acta Crystallogr A Found Adv	2015	25537383	Yes
127	13682	6841.0	0.0	0.0	Continuous cultures of fused cells secreting antibody of predefined specificity.	G Köhler, C Milstein	Nature	1975	1172191	Yes
128	6818	6818.0	184.65	184.7	The steroid and thyroid hormone receptor superfamily.	R M Evans	Science	1988	3283939	No
129	20328	6776.0	565.36	188.5	edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.	Mark D Robinson, Davis J McCarthy, Gordon K Smyth	Bioinformatics	2010	19910308	Yes
130	6681	6681.0	0.0	0.0	The thiobarbituric acid assay of sialic acids.	L Warren	J Biol Chem	1959	13672998	Yes
131	6670	6670.0	203.49	203.5	The VideoToolbox software for visual psychophysics: transforming numbers into movies.	D G Pelli	Spat Vis	1997	9176953	Yes
132	6637	6637.0	213.77	213.8	The Clinical Dementia Rating (CDR): current version and scoring rules.	J C Morris	Neurology	1993	8232972	Yes
133	6546	6546.0	172.58	172.6	Adhesion receptors of the immune system.	T A Springer	Nature	1990	1974032	No
134	19562	6520.7	586.14	195.4	The PHQ-9: validity of a brief depression severity measure.	K Kroenke, R L Spitzer, J B Williams	J Gen Intern Med	2001	11556941	Yes
135	19527	6509.0	606.19	202.1	Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.	Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien	Ann Surg	2004	15273542	Yes
136	19495	6498.3	551.72	183.9	A new generation of Ca2+ indicators with greatly improved fluorescence properties.	G Grynkiewicz, M Poenie, R Y Tsien	J Biol Chem	1985	3838314	Yes
137	12973	6486.5	0.0	0.0	Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.	Y Cheng, W H Prusoff	Biochem Pharmacol	1973	4202581	Yes
138	6478	6478.0	169.12	169.1	Angiogenesis in cancer, vascular, rheumatoid and other disease.	J Folkman	Nat Med	1995	7584949	No
139	12891	6445.5	0.0	0.0	Statistical aspects of the analysis of data from retrospective studies of disease.	N Mantel, W Haenszel	J Natl Cancer Inst	1959	13655060	Yes
140	12842	6421.0	416.56	208.3	AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading.	Oleg Trott, Arthur J Olson	J Comput Chem	2010	19499576	Yes
141	6415	6415.0	210.89	210.9	Ethical guidelines for investigations of experimental pain in conscious animals.	Manfred Zimmermann	Pain	1983	6877845	No
142	6377	6377.0	129.7	129.7	Rapid and efficient site-specific mutagenesis without phenotypic selection.	T A Kunkel	Proc Natl Acad Sci U S A	1985	3881765	Yes
143	12695	6347.5	439.27	219.6	Three approaches to qualitative content analysis.	Hsiu-Fang Hsieh, Sarah E Shannon	Qual Health Res	2005	16204405	Yes
144	6270	6270.0	126.69	126.7	Integrins: bidirectional, allosteric signaling machines.	Richard O Hynes	Cell	2002	12297042	No
145	6269	6269.0	135.64	135.6	p53, the cellular gatekeeper for growth and division.	A J Levine	Cell	1997	9039259	No
146	6191	6191.0	220.11	220.1	The Strengths and Difficulties Questionnaire: a research note.	R Goodman	J Child Psychol Psychiatry	1997	9255702	Yes
147	12330	6165.0	0.0	0.0	Prediction of creatinine clearance from serum creatinine.	D W Cockcroft, M H Gault	Nephron	1976	1244564	Yes
148	6127	6127.0	148.17	148.2	Inflammation, atherosclerosis, and coronary artery disease.	Göran K Hansson	N Engl J Med	2005	15843671	No
149	12241	6120.5	0.0	0.0	Intraclass correlations: uses in assessing rater reliability.	P E Shrout, J L Fleiss	Psychol Bull	1979	18839484	No
150	12229	6114.5	0.0	0.0	A rapid alkaline extraction procedure for screening recombinant plasmid DNA.	H C Birnboim, J Doly	Nucleic Acids Res	1979	388356	Yes
151	6079	6079.0	149.65	149.7	Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm.	T A Springer	Cell	1994	7507411	No
152	6070	6070.0	135.05	135.1	Inflammation in atherosclerosis.	Peter Libby	Nature	2002	12490960	No
153	12068	6034.0	419.45	209.7	The meaning and use of the area under a receiver operating characteristic (ROC) curve.	J A Hanley, B J McNeil	Radiology	1982	7063747	Yes
154	6005	6005.0	0.0	0.0	A Self-Rating Depression Scale.	W W Zung	Arch Gen Psychiatry	1965	14221692	Yes
155	6003	6003.0	152.39	152.4	Inositol trisphosphate and calcium signalling.	M J Berridge	Nature	1993	8381210	No
156	24010	6002.5	0.0	0.0	Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.	J M Chirgwin, A E Przybyla, R J MacDonald, W J Rutter	Biochemistry	1979	518835	Yes
157	5973	5973.0	142.89	142.9	Biochemistry and molecular cell biology of diabetic complications.	M Brownlee	Nature	2001	11742414	Yes
158	5968	5968.0	152.15	152.2	G proteins: transducers of receptor-generated signals.	A G Gilman	Annu Rev Biochem	1987	3113327	No
159	5968	5968.0	141.93	141.9	Free radicals in the physiological control of cell function.	Wulf Dröge	Physiol Rev	2002	11773609	No
160	11919	5959.5	295.83	147.9	BEDTools: a flexible suite of utilities for comparing genomic features.	Aaron R Quinlan, Ira M Hall	Bioinformatics	2010	20110278	Yes
161	23757	5939.2	798.31	199.6	G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences.	Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner	Behav Res Methods	2007	17695343	Yes
162	17493	5831.0	0.0	0.0	Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.	H Ohkawa, N Ohishi, K Yagi	Anal Biochem	1979	36810	Yes
163	5793	5793.0	157.44	157.4	A modified poisson regression approach to prospective studies with binary data.	Guangyong Zou	Am J Epidemiol	2004	15033648	Yes
164	5764	5764.0	110.39	110.4	BLAT--the BLAST-like alignment tool.	W James Kent	Genome Res	2002	11932250	Yes
165	11490	5745.0	281.45	140.7	MRBAYES: Bayesian inference of phylogenetic trees.	J P Huelsenbeck, F Ronquist	Bioinformatics	2001	11524383	Yes
166	5718	5718.0	133.0	133.0	Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis.	J Castresana	Mol Biol Evol	2000	10742046	Yes
167	5701	5701.0	143.84	143.8	Apoptosis in the pathogenesis and treatment of disease.	C B Thompson	Science	1995	7878464	No
168	11387	5693.5	320.72	160.4	EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis.	Arnaud Delorme, Scott Makeig	J Neurosci Methods	2004	15102499	Yes
169	5689	5689.0	133.92	133.9	Antimicrobial peptides of multicellular organisms.	Michael Zasloff	Nature	2002	11807545	Yes
170	11320	5660.0	0.0	0.0	The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature.	T Omura, R Sato	J Biol Chem	1964	14209971	Yes
171	5624	5624.0	139.46	139.5	Inflammation and metabolic disorders.	Gökhan S Hotamisligil	Nature	2006	17167474	No
172	11230	5615.0	252.14	126.1	Dendritic cells and the control of immunity.	J Banchereau, R M Steinman	Nature	1998	9521319	No
173	11128	5564.0	295.48	147.7	Sequencing end-labeled DNA with base-specific chemical cleavages.	A M Maxam, W Gilbert	Methods Enzymol	1980	6246368	Yes
174	5559	5559.0	0.0	0.0	Modification of seizure activity by electrical stimulation. II. Motor seizure.	R J Racine	Electroencephalogr Clin Neurophysiol	1972	4110397	Yes
175	11103	5551.5	258.45	129.2	Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features.	W Kabsch, C Sander	Biopolymers	1983	6667333	Yes
176	11007	5503.5	0.0	0.0	A series of normal stages in the development of the chick embryo.	V Hamburger, H L Hamilton	J Morphol	1951	24539719	Yes
177	5493	5493.0	0.0	0.0	Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues.	F Tietze	Anal Biochem	1969	4388022	Yes
178	5454	5454.0	0.0	0.0	Evaluation of survival data and two new rank order statistics arising in its consideration.	N Mantel	Cancer Chemother Rep	1966	5910392	Yes
179	10884	5442.0	242.07	121.0	One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.	K A Datsenko, B L Wanner	Proc Natl Acad Sci U S A	2000	10829079	Yes
180	5442	5442.0	0.0	0.0	The Environment And Disease: Association Or Causation?	A B Hill	Proc R Soc Med	1965	14283879	Yes
181	5439	5439.0	119.74	119.7	The biochemistry of apoptosis.	M O Hengartner	Nature	2000	11048727	No
182	5406	5406.0	0.0	0.0	Aging: a theory based on free radical and radiation chemistry.	D Harman	J Gerontol	1956	13332224	Yes
183	5390	5390.0	176.18	176.2	jModelTest: phylogenetic model averaging.	David Posada	Mol Biol Evol	2008	18397919	Yes
184	10761	5380.5	298.12	149.1	Neuropathological stageing of Alzheimer-related changes.	H Braak, E Braak	Acta Neuropathol	1991	1759558	No
185	10742	5371.0	253.67	126.8	A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood.	Stéphane Guindon, Olivier Gascuel	Syst Biol	2003	14530136	Yes
186	16111	5370.3	485.75	161.9	A simple salting out procedure for extracting DNA from human nucleated cells.	S A Miller, D D Dykes, H F Polesky	Nucleic Acids Res	1988	3344216	Yes
187	5348	5348.0	136.3	136.3	New M13 vectors for cloning.	J Messing	Methods Enzymol	1983	6310323	Yes
188	5342	5342.0	0.0	0.0	Mutation and cancer: statistical study of retinoblastoma.	A G Knudson	Proc Natl Acad Sci U S A	1971	5279523	Yes
189	5339	5339.0	139.6	139.6	The Cambridge Structural Database: a quarter of a million crystal structures and rising.	Frank H Allen	Acta Crystallogr B	2002	12037359	Yes
190	5324	5324.0	212.17	212.2	Orienting of attention.	M I Posner	Q J Exp Psychol	1980	7367577	Yes
191	10635	5317.5	300.27	150.1	MODELTEST: testing the model of DNA substitution.	D Posada, K A Crandall	Bioinformatics	1998	9918953	Yes
192	5313	5313.0	195.02	195.0	An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies.	Peter C Austin	Multivariate Behav Res	2011	21818162	Yes
193	5301	5301.0	0.0	0.0	Development of a rating scale for primary depressive illness.	M Hamilton	Br J Soc Clin Psychol	1967	6080235	Yes
194	5274	5274.0	153.24	153.2	Studies and perspectives of protein kinase C.	Y Nishizuka	Science	1986	3014651	No
195	5239	5239.0	127.42	127.4	The NF-kappa B and I kappa B proteins: new discoveries and insights.	A S Baldwin	Annu Rev Immunol	1996	8717528	No
196	26185	5237.0	711.61	142.3	The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.	J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G Higgins	Nucleic Acids Res	1997	9396791	Yes
197	5221	5221.0	0.0	0.0	[A micro-method of immuno-electrophoresis].	J J Scheidegger	Int Arch Allergy Appl Immunol	1955	13262900	Yes
198	5205	5205.0	149.83	149.8	A fast diffeomorphic image registration algorithm.	John Ashburner	Neuroimage	2007	17761438	Yes
199	5197	5197.0	190.34	190.3	Oxygen-derived free radicals in postischemic tissue injury.	J M McCord	N Engl J Med	1985	2981404	No
200	5181	5181.0	0.0	0.0	Index for rating diagnostic tests.	W J Youden	Cancer	1950	15405679	Yes
201	5177	5177.0	0.0	0.0	Selective extraction of polyoma DNA from infected mouse cell cultures.	B Hirt	J Mol Biol	1967	4291934	Yes
202	5137	5137.0	153.48	153.5	Developments of a water-maze procedure for studying spatial learning in the rat.	R Morris	J Neurosci Methods	1984	6471907	Yes
203	5125	5125.0	101.84	101.8	Epithelial-mesenchymal transitions in tumour progression.	Jean Paul Thiery	Nat Rev Cancer	2002	12189386	No
204	10245	5122.5	367.55	183.8	The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.	R F Furchgott, J V Zawadzki	Nature	1980	6253831	Yes
205	5088	5088.0	115.19	115.2	MUSCLE: a multiple sequence alignment method with reduced time and space complexity.	Robert C Edgar	BMC Bioinformatics	2004	15318951	Yes
206	10171	5085.5	220.13	110.1	Inflammation and cancer.	Lisa M Coussens, Zena Werb	Nature	2002	12490959	No
207	10155	5077.5	270.22	135.1	Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa.	H Schägger, G von Jagow	Anal Biochem	1987	2449095	Yes
208	5076	5076.0	187.0	187.0	Analyzing Tables Of Statistical Tests.	William R Rice	Evolution	1989	28568501	Yes
209	10141	5070.5	0.0	0.0	A quantitative description of membrane current and its application to conduction and excitation in nerve.	A L Hodgkin, A F Huxley	J Physiol	1952	12991237	Yes
210	5043	5043.0	102.17	102.2	Rho GTPases and the actin cytoskeleton.	A Hall	Science	1998	9438836	No
211	10044	5022.0	294.49	147.2	RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome.	Bo Li, Colin N Dewey	BMC Bioinformatics	2011	21816040	Yes
212	5008	5008.0	0.0	0.0	The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification.	P Lauren	Acta Pathol Microbiol Scand	1965	14320675	Yes
213	4988	4988.0	0.0	0.0	A protein binding assay for adenosine 3':5'-cyclic monophosphate.	A G Gilman	Proc Natl Acad Sci U S A	1970	4318781	Yes
214	9941	4970.5	0.0	0.0	A new depression scale designed to be sensitive to change.	S A Montgomery, M Asberg	Br J Psychiatry	1979	444788	Yes
215	14884	4961.3	537.99	179.3	Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.	S M Hsu, L Raine, H Fanger	J Histochem Cytochem	1981	6166661	Yes
216	14876	4958.7	563.84	187.9	The positive and negative syndrome scale (PANSS) for schizophrenia.	S R Kay, A Fiszbein, L A Opler	Schizophr Bull	1987	3616518	Yes
217	4953	4953.0	122.32	122.3	Emotion circuits in the brain.	J E LeDoux	Annu Rev Neurosci	2000	10845062	No
218	9871	4935.5	237.08	118.5	Comparative protein modelling by satisfaction of spatial restraints.	A Sali, T L Blundell	J Mol Biol	1993	8254673	Yes
219	4929	4929.0	0.0	0.0	Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.	C B Laurell	Anal Biochem	1966	5959431	Yes
220	9821	4910.5	238.47	119.2	WGCNA: an R package for weighted correlation network analysis.	Peter Langfelder, Steve Horvath	BMC Bioinformatics	2008	19114008	Yes
221	9806	4903.0	262.78	131.4	Differential expression analysis for sequence count data.	Simon Anders, Wolfgang Huber	Genome Biol	2010	20979621	Yes
222	9803	4901.5	352.33	176.2	Ligand: a versatile computerized approach for characterization of ligand-binding systems.	P J Munson, D Rodbard	Anal Biochem	1980	6254391	Yes
223	9748	4874.0	1262.93	631.5	Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention.	Zunyou Wu, Jennifer M McGoogan	JAMA	2020	32091533	Yes
224	4873	4873.0	131.78	131.8	Mild cognitive impairment as a diagnostic entity.	R C Petersen	J Intern Med	2004	15324362	No
225	9744	4872.0	215.43	107.7	The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.	John Hardy, Dennis J Selkoe	Science	2002	12130773	No
226	14579	4859.7	394.65	131.5	Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors.	C Yanisch-Perron, J Vieira, J Messing	Gene	1985	2985470	Yes
227	9718	4859.0	264.77	132.4	Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy.	Florian Weigend, Reinhart Ahlrichs	Phys Chem Chem Phys	2005	16240044	Yes
228	4844	4844.0	100.21	100.2	Targeting HIF-1 for cancer therapy.	Gregg L Semenza	Nat Rev Cancer	2003	13130303	No
229	14474	4824.7	358.92	119.6	A comprehensive set of sequence analysis programs for the VAX.	J Devereux, P Haeberli, O Smithies	Nucleic Acids Res	1984	6546423	Yes
230	4819	4819.0	97.75	97.8	An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.	M Kozak	Nucleic Acids Res	1987	3313277	No
231	9614	4807.0	232.61	116.3	A genetic model for colorectal tumorigenesis.	E R Fearon, B Vogelstein	Cell	1990	2188735	No
232	14390	4796.7	359.85	120.0	Inference of population structure using multilocus genotype data.	J K Pritchard, M Stephens, P Donnelly	Genetics	2000	10835412	Yes
233	9548	4774.0	317.92	159.0	Operating characteristics of a rank correlation test for publication bias.	C B Begg, M Mazumdar	Biometrics	1994	7786990	Yes
234	23864	4772.8	1110.48	222.1	MEGA6: Molecular Evolutionary Genetics Analysis version 6.0.	Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir Kumar	Mol Biol Evol	2013	24132122	Yes
235	4759	4759.0	0.0	0.0	Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis.	M Rodbell	J Biol Chem	1964	14169133	Yes
236	4749	4749.0	0.0	0.0	The clonal evolution of tumor cell populations.	P C Nowell	Science	1976	959840	Yes
237	9491	4745.5	0.0	0.0	A new technique for the assay of infectivity of human adenovirus 5 DNA.	F L Graham, A J van der Eb	Virology	1973	4705382	Yes
238	14191	4730.3	0.0	0.0	Determination of serum proteins by means of the biuret reaction.	A G Gornall, C J Bardawill, M M David	J Biol Chem	1949	18110453	Yes
239	4729	4729.0	134.65	134.7	How mitochondria produce reactive oxygen species.	Michael P Murphy	Biochem J	2009	19061483	No
240	4723	4723.0	106.91	106.9	ras oncogenes in human cancer: a review.	J L Bos	Cancer Res	1989	2547513	No
241	4712	4712.0	104.47	104.5	Cancer cell cycles.	C J Sherr	Science	1996	8939849	No
242	9388	4694.0	237.65	118.8	Improved tools for biological sequence comparison.	W R Pearson, D J Lipman	Proc Natl Acad Sci U S A	1988	3162770	Yes
243	4688	4688.0	157.08	157.1	The pathogenesis of atherosclerosis--an update.	R Ross	N Engl J Med	1986	3511384	No
244	4673	4673.0	89.31	89.3	DNA methylation patterns and epigenetic memory.	Adrian Bird	Genes Dev	2002	11782440	No
245	4663	4663.0	129.83	129.8	Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.	P Matsudaira	J Biol Chem	1987	3611052	Yes
246	4654	4654.0	0.0	0.0	Aggregation of blood platelets by adenosine diphosphate and its reversal.	G V Born	Nature	1962	13871375	Yes
247	4651	4651.0	179.93	179.9	Revisiting the behavioral model and access to medical care: does it matter?	R M Andersen	J Health Soc Behav	1995	7738325	Yes
248	13948	4649.3	485.56	161.9	Nitric oxide: physiology, pathophysiology, and pharmacology.	S Moncada, R M Palmer, E A Higgs	Pharmacol Rev	1991	1852778	No
249	23215	4643.0	0.0	0.0	An inventory for measuring depression.	A T Beck, C H Ward, M Mendelson, J Mock, J Erbaugh	Arch Gen Psychiatry	1961	13688369	Yes
250	4636	4636.0	0.0	0.0	The need for a new medical model: a challenge for biomedicine.	G L Engel	Science	1977	847460	Yes
251	18535	4633.8	547.69	136.9	MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0.	Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir Kumar	Mol Biol Evol	2007	17488738	Yes
252	4615	4615.0	0.0	0.0	A rapid banding technique for human chromosomes.	M Seabright	Lancet	1971	4107917	Yes
253	4600	4600.0	0.0	0.0	The McGill Pain Questionnaire: major properties and scoring methods.	Ronald Melzack	Pain	1975	1235985	Yes
254	13780	4593.3	304.91	101.6	Refinement of macromolecular structures by the maximum-likelihood method.	G N Murshudov, A A Vagin, E J Dodson	Acta Crystallogr D Biol Crystallogr	1997	15299926	Yes
255	4579	4579.0	102.47	102.5	Alzheimer's disease: genes, proteins, and therapy.	D J Selkoe	Physiol Rev	2001	11274343	No
256	9122	4561.0	255.44	127.7	The rise of graphene.	A K Geim, K S Novoselov	Nat Mater	2007	17330084	Yes
257	9105	4552.5	0.0	0.0	Parkinsonism: onset, progression and mortality.	M M Hoehn, M D Yahr	Neurology	1967	6067254	Yes
258	9098	4549.0	206.9	103.5	MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification.	Jürgen Cox, Matthias Mann	Nat Biotechnol	2008	19029910	Yes
259	4543	4543.0	0.0	0.0	Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation.	W H Harris	J Bone Joint Surg Am	1969	5783851	Yes
260	4515	4515.0	102.28	102.3	Prions.	S B Prusiner	Proc Natl Acad Sci U S A	1998	9811807	No
261	4497	4497.0	97.78	97.8	ras genes.	M Barbacid	Annu Rev Biochem	1987	3304147	No
262	8961	4480.5	201.48	100.7	Primer3 on the WWW for general users and for biologist programmers.	S Rozen, H Skaletsky	Methods Mol Biol	2000	10547847	Yes
263	4479	4479.0	0.0	0.0	The Limited In Vitro Lifetime Of Human Diploid Cell Strains.	L Hayflick	Exp Cell Res	1965	14315085	Yes
264	8944	4472.0	0.0	0.0	A simplified method of evaluating dose-effect experiments.	J T Litchfield, F Wilcoxon	J Pharmacol Exp Ther	1949	18152921	Yes
265	4467	4467.0	109.13	109.1	A new method for predicting signal sequence cleavage sites.	G von Heijne	Nucleic Acids Res	1986	3714490	Yes
266	13346	4448.7	1221.05	407.0	Cancer statistics, 2019.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2019	30620402	Yes
267	4444	4444.0	140.94	140.9	Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence.	Ilan H Meyer	Psychol Bull	2003	12956539	No
268	17772	4443.0	0.0	0.0	A new and rapid colorimetric determination of acetylcholinesterase activity.	G L Ellman, K D Courtney, V Andres, R M Feather-Stone	Biochem Pharmacol	1961	13726518	Yes
269	8879	4439.5	0.0	0.0	Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).	J M McCord, I Fridovich	J Biol Chem	1969	5389100	Yes
270	4439	4439.0	101.73	101.7	Tandem repeats finder: a program to analyze DNA sequences.	G Benson	Nucleic Acids Res	1999	9862982	Yes
271	4419	4419.0	90.36	90.4	Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.	M Kozak	Cell	1986	3943125	Yes
272	4410	4410.0	149.16	149.2	Whatever happened to qualitative description?	M Sandelowski	Res Nurs Health	2000	10940958	No
273	8786	4393.0	0.0	0.0	A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.	W M Bonner, R A Laskey	Eur J Biochem	1974	4850204	Yes
274	4388	4388.0	102.55	102.5	Cancer. p53, guardian of the genome.	D P Lane	Nature	1992	1614522	No
275	26312	4385.3	958.6	159.8	Global cancer statistics.	Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David Forman	CA Cancer J Clin	2011	21296855	Yes
276	4381	4381.0	92.1	92.1	Alternative activation of macrophages.	Siamon Gordon	Nat Rev Immunol	2003	12511873	No
277	8754	4377.0	0.0	0.0	Assessment of coma and impaired consciousness. A practical scale.	G Teasdale, B Jennett	Lancet	1974	4136544	Yes
278	4376	4376.0	0.0	0.0	The genetical evolution of social behaviour. I.	W D Hamilton	J Theor Biol	1964	5875341	Yes
279	8701	4350.5	234.97	117.5	A synaptic model of memory: long-term potentiation in the hippocampus.	T V Bliss, G L Collingridge	Nature	1993	8421494	No
280	17394	4348.5	468.07	117.0	Features and development of Coot.	P Emsley, B Lohkamp, W G Scott, K Cowtan	Acta Crystallogr D Biol Crystallogr	2010	20383002	Yes
281	4346	4346.0	0.0	0.0	Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents.	M M Mesulam	J Histochem Cytochem	1978	24068	Yes
282	4338	4338.0	112.74	112.7	Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C.	Y Nishizuka	Science	1992	1411571	No
283	8646	4323.0	0.0	0.0	Functional Evaluation: The Barthel Index.	F I Mahoney, D W Barthel	Md State Med J	1965	14258950	Yes
284	8606	4303.0	0.0	0.0	Preparation of iodine-131 labelled human growth hormone of high specific activity.	W M Hunter, F C Greenwood	Nature	1962	14450081	Yes
285	8595	4297.5	200.71	100.4	SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling.	N Guex, M C Peitsch	Electrophoresis	1997	9504803	Yes
286	4290	4290.0	137.47	137.5	Updating P300: an integrative theory of P3a and P3b.	John Polich	Clin Neurophysiol	2007	17573239	No
287	4279	4279.0	113.71	113.7	The molecular heterogeneity of protein kinase C and its implications for cellular regulation.	Y Nishizuka	Nature	1988	3045562	No
288	4270	4270.0	93.84	93.8	Apoptosis by death factor.	S Nagata	Cell	1997	9039262	No
289	25569	4261.5	984.6	164.1	MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods.	Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir Kumar	Mol Biol Evol	2011	21546353	Yes
290	8522	4261.0	0.0	0.0	Assessment of older people: self-maintaining and instrumental activities of daily living.	M P Lawton, E M Brody	Gerontologist	1969	5349366	Yes
291	4253	4253.0	100.98	101.0	Mechanisms of angiogenesis.	W Risau	Nature	1997	9109485	No
292	4251	4251.0	82.54	82.5	The phosphoinositide 3-kinase pathway.	Lewis C Cantley	Science	2002	12040186	No
293	4247	4247.0	111.38	111.4	Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation.	A H Wyllie	Nature	1980	6245367	Yes
294	12740	4246.7	464.77	154.9	Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups.	Allison Tong, Peter Sainsbury, Jonathan Craig	Int J Qual Health Care	2007	17872937	Yes
295	8487	4243.5	319.7	159.8	Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models.	Kristopher J Preacher, Andrew F Hayes	Behav Res Methods	2008	18697684	Yes
296	4234	4234.0	0.0	0.0	Amino acid metabolism in mammalian cell cultures.	H Eagle	Science	1959	13675766	Yes
297	4229	4229.0	89.23	89.2	Wnt/beta-catenin signaling in development and disease.	Hans Clevers	Cell	2006	17081971	No
298	4227	4227.0	0.0	0.0	Estimation of nuclear population from microtome sections.	M Abercrombie	Anat Rec	1946	21015608	Yes
299	8443	4221.5	204.7	102.3	Collective dynamics of 'small-world' networks.	D J Watts, S H Strogatz	Nature	1998	9623998	Yes
300	4213	4213.0	94.13	94.1	Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing.	S Henikoff	Gene	1984	6235151	Yes
301	4212	4212.0	0.0	0.0	The colorimetric estimation of formaldehyde by means of the Hantzsch reaction.	T Nash	Biochem J	1953	13105648	Yes
302	12614	4204.7	698.44	232.8	Cancer statistics, 2016.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2016	26742998	Yes
303	4197	4197.0	0.0	0.0	A relation between non-esterified fatty acids in plasma and the metabolism of glucose.	V P Dole	J Clin Invest	1956	13286333	Yes
304	8392	4196.0	648.71	324.4	A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research.	Terry K Koo, Mae Y Li	J Chiropr Med	2016	27330520	Yes
305	4188	4188.0	87.52	87.5	The retinoblastoma protein and cell cycle control.	R A Weinberg	Cell	1995	7736585	No
306	8351	4175.5	234.48	117.2	Ab initio molecular dynamics for liquid metals.	Kresse, Hafner	Phys Rev B Condens Matter	1993	10004490	Yes
307	8339	4169.5	291.77	145.9	Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness.	U H Graneheim, B Lundman	Nurse Educ Today	2004	14769454	No
308	4165	4165.0	126.16	126.2	Glutamate neurotoxicity and diseases of the nervous system.	D W Choi	Neuron	1988	2908446	No
309	4147	4147.0	87.15	87.2	Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.	C J Marshall	Cell	1995	7834738	No
310	4134	4134.0	100.27	100.3	Why most published research findings are false.	John P A Ioannidis	PLoS Med	2005	16060722	Yes
311	8262	4131.0	178.08	89.0	Genomic sequencing.	G M Church, W Gilbert	Proc Natl Acad Sci U S A	1984	6326095	Yes
312	4131	4131.0	75.68	75.7	Generalized lacZ expression with the ROSA26 Cre reporter strain.	P Soriano	Nat Genet	1999	9916792	Yes
313	4119	4119.0	0.0	0.0	The detection of disease clustering and a generalized regression approach.	N Mantel	Cancer Res	1967	6018555	Yes
314	4116	4116.0	0.0	0.0	The determination of enzyme inhibitor constants.	M Dixon	Biochem J	1953	13093635	Yes
315	4113	4113.0	0.0	0.0	Determination of protein: a modification of the Lowry method that gives a linear photometric response.	E F Hartree	Anal Biochem	1972	4115981	Yes
316	4100	4100.0	0.0	0.0	Bone: formation by autoinduction.	M R Urist	Science	1965	5319761	Yes
317	4098	4098.0	150.87	150.9	EuroQol: the current state of play.	R Brooks	Health Policy	1996	10158943	No
318	12291	4097.0	1607.79	535.9	Cancer statistics, 2020.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2020	31912902	Yes
319	12273	4091.0	543.72	181.2	Development and validation of brief measures of positive and negative affect: the PANAS scales.	D Watson, L A Clark, A Tellegen	J Pers Soc Psychol	1988	3397865	Yes
320	4062	4062.0	89.38	89.4	Atherosclerosis.	A J Lusis	Nature	2000	11001066	No
321	4059	4059.0	0.0	0.0	New methods for calculating metabolic rate with special reference to protein metabolism.	J B De B Weir	J Physiol	1949	15394301	Yes
322	4055	4055.0	202.71	202.7	Executive functions.	Adele Diamond	Annu Rev Psychol	2013	23020641	No
323	8070	4035.0	235.29	117.6	Estimating F-Statistics For The Analysis Of Population Structure.	B S Weir, C Clark Cockerham	Evolution	1984	28563791	Yes
324	4032	4032.0	126.65	126.7	Bacterial evolution.	C R Woese	Microbiol Rev	1987	2439888	No
325	4025	4025.0	90.34	90.3	PAML: a program package for phylogenetic analysis by maximum likelihood.	Z Yang	Comput Appl Biosci	1997	9367129	Yes
326	24102	4017.0	796.32	132.7	Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.	D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C Turner	Diabetologia	1985	3899825	Yes
327	12014	4004.7	868.11	289.4	Cancer statistics, 2018.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2018	29313949	Yes
328	4001	4001.0	0.0	0.0	Staining of tissue sections for electron microscopy with heavy metals.	M L Watson	J Biophys Biochem Cytol	1958	13563554	Yes
329	3998	3998.0	103.74	103.7	Integrins: a family of cell surface receptors.	R O Hynes	Cell	1987	3028640	No
330	3975	3975.0	104.94	104.9	Staphylococcus aureus infections.	F D Lowy	N Engl J Med	1998	9709046	No
331	3959	3959.0	128.12	128.1	Tissue destruction by neutrophils.	S J Weiss	N Engl J Med	1989	2536474	No
332	7907	3953.5	331.67	165.8	The timed "Up & Go": a test of basic functional mobility for frail elderly persons.	D Podsiadlo, S Richardson	J Am Geriatr Soc	1991	1991946	Yes
333	7902	3951.0	0.0	0.0	Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.	D E Paglia, W N Valentine	J Lab Clin Med	1967	6066618	Yes
334	23691	3948.5	869.93	145.0	Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support.	Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G Conde	J Biomed Inform	2009	18929686	Yes
335	3941	3941.0	0.0	0.0	Disc Electrophoresis. I. Background And Theory.	L Ornstein	Ann N Y Acad Sci	1964	14240533	Yes
336	3938	3938.0	107.15	107.2	What is the evidence that tumors are angiogenesis dependent?	J Folkman	J Natl Cancer Inst	1990	1688381	No
337	3936	3936.0	148.87	148.9	Measuring the accuracy of diagnostic systems.	J A Swets	Science	1988	3287615	No
338	3932	3932.0	83.16	83.2	The green fluorescent protein.	R Y Tsien	Annu Rev Biochem	1998	9759496	No
339	7864	3932.0	0.0	0.0	Radiological assessment of osteo-arthrosis.	J H Kellgren, J S Lawrence	Ann Rheum Dis	1957	13498604	Yes
340	7857	3928.5	0.0	0.0	Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.	H Aviv, P Leder	Proc Natl Acad Sci U S A	1972	4504350	Yes
341	3921	3921.0	0.0	0.0	A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients.	E Pfeiffer	J Am Geriatr Soc	1975	1159263	Yes
342	11721	3907.0	712.04	237.3	Cancer Statistics, 2017.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2017	28055103	Yes
343	7811	3905.5	258.96	129.5	DnaSP v5: a software for comprehensive analysis of DNA polymorphism data.	P Librado, J Rozas	Bioinformatics	2009	19346325	Yes
344	3903	3903.0	0.0	0.0	Evolution in Mendelian Populations.	S Wright	Genetics	1931	17246615	Yes
345	3900	3900.0	85.77	85.8	Protein production by auto-induction in high density shaking cultures.	F William Studier	Protein Expr Purif	2005	15915565	Yes
346	7794	3897.0	292.26	146.1	The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay.	I F Benzie, J J Strain	Anal Biochem	1996	8660627	Yes
347	3891	3891.0	119.88	119.9	Nitric oxide as a secretory product of mammalian cells.	C Nathan	FASEB J	1992	1381691	No
348	11639	3879.7	438.37	146.1	A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity.	J Ware, M Kosinski, S D Keller	Med Care	1996	8628042	Yes
349	3862	3862.0	0.0	0.0	Pharmacological implications of microsomal enzyme induction.	A H Conney	Pharmacol Rev	1967	4383307	Yes
350	3859	3859.0	77.65	77.7	Hypoxia--a key regulatory factor in tumour growth.	Adrian L Harris	Nat Rev Cancer	2002	11902584	No
351	3852	3852.0	95.12	95.1	Multiple sequence alignment with hierarchical clustering.	F Corpet	Nucleic Acids Res	1988	2849754	Yes
352	3852	3852.0	0.0	0.0	Principles that govern the folding of protein chains.	C B Anfinsen	Science	1973	4124164	Yes
353	11555	3851.7	464.35	154.8	A global measure of perceived stress.	S Cohen, T Kamarck, R Mermelstein	J Health Soc Behav	1983	6668417	Yes
354	3846	3846.0	0.0	0.0	The Scree Test For The Number Of Factors.	R B Cattell	Multivariate Behav Res	1966	26828106	Yes
355	7657	3828.5	145.02	72.5	A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.	R S Sikorski, P Hieter	Genetics	1989	2659436	Yes
356	3825	3825.0	0.0	0.0	Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit.	J Cohen	Psychol Bull	1968	19673146	Yes
357	11458	3819.3	0.0	0.0	Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.	J F Kerr, A H Wyllie, A R Currie	Br J Cancer	1972	4561027	No
358	3817	3817.0	0.0	0.0	Preparation of isolated rat liver cells.	P O Seglen	Methods Cell Biol	1976	177845	No
359	7621	3810.5	196.06	98.0	tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence.	T M Lowe, S R Eddy	Nucleic Acids Res	1997	9023104	Yes
360	3803	3803.0	112.54	112.5	Soft self-consistent pseudopotentials in a generalized eigenvalue formalism.	Vanderbilt	Phys Rev B Condens Matter	1990	9993096	Yes
361	3793	3793.0	103.56	103.6	Revisions in the International System for Staging Lung Cancer.	C F Mountain	Chest	1997	9187198	Yes
362	3790	3790.0	79.47	79.5	Protein secondary structure prediction based on position-specific scoring matrices.	D T Jones	J Mol Biol	1999	10493868	Yes
363	15139	3784.8	593.1	148.3	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	Ann Intern Med	2009	19622511	No
364	3783	3783.0	80.56	80.6	A catalogue of splice junction sequences.	S M Mount	Nucleic Acids Res	1982	7063411	Yes
365	3769	3769.0	90.96	91.0	Caspases: the executioners of apoptosis.	G M Cohen	Biochem J	1997	9337844	No
366	3761	3761.0	124.08	124.1	How do you feel--now? The anterior insula and human awareness.	A D Bud Craig	Nat Rev Neurosci	2009	19096369	No
367	3759	3759.0	0.0	0.0	Estimation of the molecular weights of proteins by Sephadex gel-filtration.	P Andrews	Biochem J	1964	4158310	Yes
368	3747	3747.0	83.61	83.6	Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.	Rakesh K Jain	Science	2005	15637262	No
369	7483	3741.5	182.9	91.5	Mitochondria and apoptosis.	D R Green, J C Reed	Science	1998	9721092	No
370	3741	3741.0	107.33	107.3	Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity.	J H Morrissey	Anal Biochem	1981	6172996	Yes
371	3735	3735.0	125.3	125.3	Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD.	Russell A Barkley	Psychol Bull	1997	9000892	No
372	11202	3734.0	215.46	71.8	Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.	J D Dignam, R M Lebovitz, R G Roeder	Nucleic Acids Res	1983	6828386	Yes
373	3730	3730.0	146.05	146.1	FreeSurfer.	Bruce Fischl	Neuroimage	2012	22248573	No
374	3728	3728.0	78.0	78.0	TGF-beta signal transduction.	J Massagué	Annu Rev Biochem	1998	9759503	No
375	11176	3725.3	0.0	0.0	Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.	W H Habig, M J Pabst, W B Jakoby	J Biol Chem	1974	4436300	Yes
376	11174	3724.7	445.95	148.7	HTSeq--a Python framework to work with high-throughput sequencing data.	Simon Anders, Paul Theodor Pyl, Wolfgang Huber	Bioinformatics	2015	25260700	Yes
377	3717	3717.0	99.52	99.5	Sequencing technologies - the next generation.	Michael L Metzker	Nat Rev Genet	2010	19997069	No
378	3712	3712.0	88.88	88.9	Free R value: a novel statistical quantity for assessing the accuracy of crystal structures.	A T Brünger	Nature	1992	18481394	Yes
379	7421	3710.5	191.31	95.7	Control of goal-directed and stimulus-driven attention in the brain.	Maurizio Corbetta, Gordon L Shulman	Nat Rev Neurosci	2002	11994752	No
380	3702	3702.0	0.0	0.0	A membrane-filter technique for the detection of complementary DNA.	D T Denhardt	Biochem Biophys Res Commun	1966	5963888	Yes
381	14774	3693.5	389.64	97.4	Global cancer statistics, 2002.	D Max Parkin, Freddie Bray, J Ferlay, Paola Pisani	CA Cancer J Clin	2005	15761078	Yes
382	3693	3693.0	73.32	73.3	Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.	G R Martin	Proc Natl Acad Sci U S A	1981	6950406	Yes
383	3688	3688.0	99.82	99.8	Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group.	R B D'Agostino	Stat Med	1998	9802183	Yes
384	25798	3685.4	582.05	83.1	UCSF Chimera--a visualization system for exploratory research and analysis.	Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin	J Comput Chem	2004	15264254	Yes
385	3683	3683.0	86.23	86.2	Novel proteinaceous infectious particles cause scrapie.	S B Prusiner	Science	1982	6801762	Yes
386	11030	3676.7	356.89	119.0	Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.	E R DeLong, D M DeLong, D L Clarke-Pearson	Biometrics	1988	3203132	Yes
387	3676	3676.0	82.76	82.8	Instability and decay of the primary structure of DNA.	T Lindahl	Nature	1993	8469282	No
388	3659	3659.0	66.93	66.9	Somatic generation of antibody diversity.	S Tonegawa	Nature	1983	6300689	No
389	3656	3656.0	93.88	93.9	Oxidative stress, antioxidants and stress tolerance.	Ron Mittler	Trends Plant Sci	2002	12234732	No
390	7255	3627.5	137.12	68.6	Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.	A H Brand, N Perrimon	Development	1993	8223268	Yes
391	3627	3627.0	95.13	95.1	Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?	Kim A Brogden	Nat Rev Microbiol	2005	15703760	No
392	7248	3624.0	0.0	0.0	The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.	R C Graham, M J Karnovsky	J Histochem Cytochem	1966	5962951	Yes
393	14483	3620.8	551.41	137.9	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	BMJ	2009	19622551	No
394	3619	3619.0	106.11	106.1	What's wrong with Bonferroni adjustments.	T V Perneger	BMJ	1998	9553006	No
395	3610	3610.0	108.85	108.8	Inositol trisphosphate and diacylglycerol as second messengers.	M J Berridge	Biochem J	1984	6146314	No
396	3601	3601.0	100.58	100.6	Biological roles of oligosaccharides: all of the theories are correct.	A Varki	Glycobiology	1993	8490246	No
397	7202	3601.0	206.96	103.5	BEAST: Bayesian evolutionary analysis by sampling trees.	Alexei J Drummond, Andrew Rambaut	BMC Evol Biol	2007	17996036	Yes
398	3599	3599.0	0.0	0.0	Basic principles of ROC analysis.	C E Metz	Semin Nucl Med	1978	112681	Yes
399	3599	3599.0	0.0	0.0	Generalized expectancies for internal versus external control of reinforcement.	J B Rotter	Psychol Monogr	1966	5340840	No
400	3599	3599.0	79.06	79.1	Scaling and assessment of data quality.	Philip Evans	Acta Crystallogr D Biol Crystallogr	2006	16369096	No
401	7192	3596.0	160.29	80.1	Functional rafts in cell membranes.	K Simons, E Ikonen	Nature	1997	9177342	No
402	3594	3594.0	117.06	117.1	genepop'007: a complete re-implementation of the genepop software for Windows and Linux.	François Rousset	Mol Ecol Resour	2008	21585727	Yes
403	3587	3587.0	0.0	0.0	Observational study of behavior: sampling methods.	J Altmann	Behaviour	1974	4597405	No
404	3581	3581.0	135.76	135.8	A concordance correlation coefficient to evaluate reproducibility.	L I Lin	Biometrics	1989	2720055	Yes
405	3560	3560.0	92.09	92.1	The origins and the future of microfluidics.	George M Whitesides	Nature	2006	16871203	No
406	3557	3557.0	84.63	84.6	Marrow stromal cells as stem cells for nonhematopoietic tissues.	D J Prockop	Science	1997	9082988	No
407	3555	3555.0	80.17	80.2	Folding DNA to create nanoscale shapes and patterns.	Paul W K Rothemund	Nature	2006	16541064	Yes
408	14190	3547.5	345.85	86.5	Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.	Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg	Genome Biol	2009	19261174	Yes
409	3537	3537.0	168.93	168.9	Interrater reliability: the kappa statistic.	Mary L McHugh	Biochem Med (Zagreb)	2012	23092060	Yes
410	3536	3536.0	103.71	103.7	Protective and damaging effects of stress mediators.	B S McEwen	N Engl J Med	1998	9428819	No
411	7069	3534.5	199.99	100.0	Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis.	S Duval, R Tweedie	Biometrics	2000	10877304	Yes
412	14124	3531.0	472.48	118.1	A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu.	Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge Krieg	J Chem Phys	2010	20423165	Yes
413	10582	3527.3	510.7	170.2	Deep learning.	Yann LeCun, Yoshua Bengio, Geoffrey Hinton	Nature	2015	26017442	No
414	3510	3510.0	106.1	106.1	Functions of DNA methylation: islands, start sites, gene bodies and beyond.	Peter A Jones	Nat Rev Genet	2012	22641018	No
415	6994	3497.0	0.0	0.0	A new method for sequencing DNA.	A M Maxam, W Gilbert	Proc Natl Acad Sci U S A	1977	265521	Yes
416	3495	3495.0	71.05	71.0	Mammalian neural stem cells.	F H Gage	Science	2000	10688783	No
417	3495	3495.0	87.87	87.9	I-TASSER server for protein 3D structure prediction.	Yang Zhang	BMC Bioinformatics	2008	18215316	Yes
418	3494	3494.0	92.32	92.3	The adolescent brain and age-related behavioral manifestations.	L P Spear	Neurosci Biobehav Rev	2000	10817843	No
419	17465	3493.0	497.79	99.6	Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.	O P Hamill, A Marty, E Neher, B Sakmann, F J Sigworth	Pflugers Arch	1981	6270629	Yes
420	3492	3492.0	0.0	0.0	Statistical estimations in enzyme kinetics.	G N Wilkinson	Biochem J	1961	13785321	Yes
421	3489	3489.0	0.0	0.0	Spectroscopic determination of tryptophan and tyrosine in proteins.	H Edelhoch	Biochemistry	1967	6049437	Yes
422	20889	3481.5	1056.43	176.1	Global cancer statistics, 2012.	Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin Jemal	CA Cancer J Clin	2015	25651787	Yes
423	3479	3479.0	110.35	110.3	Emerging adulthood. A theory of development from the late teens through the twenties.	J J Arnett	Am Psychol	2000	10842426	Yes
424	3472	3472.0	102.7	102.7	Graphene: status and prospects.	A K Geim	Science	2009	19541989	Yes
425	6941	3470.5	176.43	88.2	An integrative theory of prefrontal cortex function.	E K Miller, J D Cohen	Annu Rev Neurosci	2001	11283309	No
426	3463	3463.0	90.32	90.3	Microglia: a sensor for pathological events in the CNS.	G W Kreutzberg	Trends Neurosci	1996	8843599	No
427	3460	3460.0	66.57	66.6	Signal transduction by the JNK group of MAP kinases.	R J Davis	Cell	2000	11057897	No
428	6906	3453.0	181.85	90.9	The basics of epithelial-mesenchymal transition.	Raghu Kalluri, Robert A Weinberg	J Clin Invest	2009	19487818	No
429	3447	3447.0	0.0	0.0	Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.	J D Rowley	Nature	1973	4126434	Yes
430	3441	3441.0	103.85	103.8	Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans.	L R Squire	Psychol Rev	1992	1594723	No
431	6881	3440.5	163.39	81.7	"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.	A P Feinberg, B Vogelstein	Anal Biochem	1984	6329026	Yes
432	3440	3440.0	0.0	0.0	The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid.	J F Woessner	Arch Biochem Biophys	1961	13786180	Yes
433	3433	3433.0	84.89	84.9	The heat-shock response.	S Lindquist	Annu Rev Biochem	1986	2427013	No
434	10298	3432.7	419.44	139.8	Cancer statistics, 2013.	Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal	CA Cancer J Clin	2013	23335087	Yes
435	3429	3429.0	95.86	95.9	Drug combination studies and their synergy quantification using the Chou-Talalay method.	Ting-Chao Chou	Cancer Res	2010	20068163	Yes
436	6834	3417.0	125.57	62.8	Translating the histone code.	T Jenuwein, C D Allis	Science	2001	11498575	No
437	3416	3416.0	79.42	79.4	Glutamate uptake.	N C Danbolt	Prog Neurobiol	2001	11369436	No
438	3414	3414.0	72.32	72.3	Profile hidden Markov models.	S R Eddy	Bioinformatics	1998	9918945	No
439	6826	3413.0	245.77	122.9	Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows.	Laurent Excoffier, Heidi E L Lischer	Mol Ecol Resour	2010	21565059	Yes
440	3408	3408.0	96.73	96.7	EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis.	W Klimesch	Brain Res Brain Res Rev	1999	10209231	No
441	30644	3404.9	807.16	89.7	The Sequence Alignment/Map format and SAMtools.	Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin	Bioinformatics	2009	19505943	Yes
442	3401	3401.0	78.57	78.6	Nonalcoholic fatty liver disease.	Paul Angulo	N Engl J Med	2002	11961152	No
443	3396	3396.0	86.86	86.9	Origin and physiological roles of inflammation.	Ruslan Medzhitov	Nature	2008	18650913	No
444	3395	3395.0	79.64	79.6	The dendritic cell system and its role in immunogenicity.	R M Steinman	Annu Rev Immunol	1991	1910679	No
445	6787	3393.5	155.9	78.0	Inference of macromolecular assemblies from crystalline state.	Evgeny Krissinel, Kim Henrick	J Mol Biol	2007	17681537	Yes
446	6787	3393.5	300.75	150.4	phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data.	Paul J McMurdie, Susan Holmes	PLoS One	2013	23630581	Yes
447	3389	3389.0	0.0	0.0	Estimation of average heterozygosity and genetic distance from a small number of individuals.	M Nei	Genetics	1978	17248844	Yes
448	6776	3388.0	174.14	87.1	TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.	T R Mosmann, R L Coffman	Annu Rev Immunol	1989	2523712	No
449	6772	3386.0	0.0	0.0	Receptive fields, binocular interaction and functional architecture in the cat's visual cortex.	D H Hubel, T N Wiesel	J Physiol	1962	14449617	Yes
450	10157	3385.7	0.0	0.0	The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity.	F C Greenwood, W M Hunter, J S Glover	Biochem J	1963	14097352	Yes
451	6770	3385.0	0.0	0.0	Microsomal lipid peroxidation.	J A Buege, S D Aust	Methods Enzymol	1978	672633	Yes
452	3385	3385.0	133.37	133.4	Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine.	O W Griffith	Anal Biochem	1980	7416462	Yes
453	3384	3384.0	93.35	93.3	Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.	R W Mahley	Science	1988	3283935	No
454	3368	3368.0	109.49	109.5	Modeling valuations for EuroQol health states.	P Dolan	Med Care	1997	9366889	Yes
455	3368	3368.0	81.55	81.5	Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies.	Ting-Chao Chou	Pharmacol Rev	2006	16968952	No
456	10099	3366.3	495.62	165.2	Cancer statistics, 2015.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2015	25559415	Yes
457	6718	3359.0	165.67	82.8	The plant immune system.	Jonathan D G Jones, Jeffery L Dangl	Nature	2006	17108957	No
458	6704	3352.0	173.16	86.6	Fast and accurate long-read alignment with Burrows-Wheeler transform.	Heng Li, Richard Durbin	Bioinformatics	2010	20080505	Yes
459	10054	3351.3	253.41	84.5	Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists.	Da Wei Huang, Brad T Sherman, Richard A Lempicki	Nucleic Acids Res	2009	19033363	Yes
460	10052	3350.7	381.69	127.2	Cancer statistics, 2012.	Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal	CA Cancer J Clin	2012	22237781	Yes
461	3348	3348.0	0.0	0.0	Some factors in the interpretation of protein denaturation.	W Kauzmann	Adv Protein Chem	1959	14404936	Yes
462	3342	3342.0	68.91	68.9	The scanning model for translation: an update.	M Kozak	J Cell Biol	1989	2645293	No
463	3329	3329.0	68.55	68.5	Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.	M Kozak	Nucleic Acids Res	1984	6694911	Yes
464	3324	3324.0	84.79	84.8	Biologic basis for interleukin-1 in disease.	C A Dinarello	Blood	1996	8630372	No
465	3322	3322.0	73.46	73.5	Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.	H F Dvorak	N Engl J Med	1986	3537791	No
466	3315	3315.0	0.0	0.0	Equilibrium Ultracentrifugation Of Dilute Solutions.	D A Yphantis	Biochemistry	1964	14155091	Yes
467	3313	3313.0	84.42	84.4	Gene regulation by steroid hormones.	M Beato	Cell	1989	2644044	No
468	3308	3308.0	76.43	76.4	Tolerance, danger, and the extended family.	P Matzinger	Annu Rev Immunol	1994	8011301	No
469	3305	3305.0	80.42	80.4	Neural networks and physical systems with emergent collective computational abilities.	J J Hopfield	Proc Natl Acad Sci U S A	1982	6953413	Yes
470	3305	3305.0	168.02	168.0	Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs.	Daniël Lakens	Front Psychol	2013	24324449	No
471	3298	3298.0	94.9	94.9	Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis.	Thomas Welton	Chem Rev	1999	11849019	Yes
472	3294	3294.0	84.04	84.0	The pathobiology of diabetic complications: a unifying mechanism.	Michael Brownlee	Diabetes	2005	15919781	No
473	3278	3278.0	0.0	0.0	The magical number seven plus or minus two: some limits on our capacity for processing information.	G A Miller	Psychol Rev	1956	13310704	Yes
474	6549	3274.5	186.24	93.1	Velvet: algorithms for de novo short read assembly using de Bruijn graphs.	Daniel R Zerbino, Ewan Birney	Genome Res	2008	18349386	Yes
475	16371	3274.2	646.42	129.3	The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research.	D J Buysse, C F Reynolds, T H Monk, S R Berman, D J Kupfer	Psychiatry Res	1989	2748771	Yes
476	13079	3269.8	303.94	76.0	Improved methods for building protein models in electron density maps and the location of errors in these models.	T A Jones, J Y Zou, S W Cowan, M Kjeldgaard	Acta Crystallogr A	1991	2025413	Yes
477	3257	3257.0	93.74	93.7	Non-coding RNAs in human disease.	Manel Esteller	Nat Rev Genet	2011	22094949	No
478	3256	3256.0	81.89	81.9	How do you feel? Interoception: the sense of the physiological condition of the body.	A D Craig	Nat Rev Neurosci	2002	12154366	No
479	6507	3253.5	131.86	65.9	Statistical significance for genomewide studies.	John D Storey, Robert Tibshirani	Proc Natl Acad Sci U S A	2003	12883005	Yes
480	6472	3236.0	125.79	62.9	The ubiquitin system.	A Hershko, A Ciechanover	Annu Rev Biochem	1998	9759494	No
481	3232	3232.0	86.78	86.8	ABC transporters: from microorganisms to man.	C F Higgins	Annu Rev Cell Biol	1992	1282354	No
482	3230	3230.0	101.85	101.8	Health promotion by social cognitive means.	Albert Bandura	Health Educ Behav	2004	15090118	Yes
483	3228	3228.0	92.9	92.9	Inositol trisphosphate and diacylglycerol: two interacting second messengers.	M J Berridge	Annu Rev Biochem	1987	3304132	No
484	22570	3224.3	6246.5	892.4	Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.	Hyuna Sung, Jacques Ferlay, Rebecca L Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, Freddie Bray	CA Cancer J Clin	2021	33538338	Yes
485	6446	3223.0	140.54	70.3	Angiogenesis in cancer and other diseases.	P Carmeliet, R K Jain	Nature	2000	11001068	No
486	3210	3210.0	78.68	78.7	Wound healing--aiming for perfect skin regeneration.	P Martin	Science	1997	9082989	No
487	3198	3198.0	79.29	79.3	The basis of anisotropic water diffusion in the nervous system - a technical review.	Christian Beaulieu	NMR Biomed	2002	12489094	No
488	6395	3197.5	0.0	0.0	Human malaria parasites in continuous culture.	W Trager, J B Jensen	Science	1976	781840	Yes
489	3197	3197.0	69.82	69.8	Activators and target genes of Rel/NF-kappaB transcription factors.	H L Pahl	Oncogene	1999	10602461	No
490	3194	3194.0	59.69	59.7	Cell signaling by receptor tyrosine kinases.	J Schlessinger	Cell	2000	11057895	No
491	3192	3192.0	184.12	184.1	Minimap2: pairwise alignment for nucleotide sequences.	Heng Li	Bioinformatics	2018	29750242	Yes
492	3191	3191.0	79.33	79.3	The transforming growth factor-beta family.	J Massagué	Annu Rev Cell Biol	1990	2177343	No
493	6363	3181.5	153.17	76.6	Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase.	C Tuerk, L Gold	Science	1990	2200121	Yes
494	6358	3179.0	224.84	112.4	FLASH: fast length adjustment of short reads to improve genome assemblies.	Tanja Magoč, Steven L Salzberg	Bioinformatics	2011	21903629	Yes
495	3178	3178.0	86.87	86.9	Hay fever, hygiene, and household size.	D P Strachan	BMJ	1989	2513902	Yes
496	3178	3178.0	63.64	63.6	STATs and gene regulation.	J E Darnell	Science	1997	9287210	No
497	3172	3172.0	86.32	86.3	Mesenchymal stem cells.	A I Caplan	J Orthop Res	1991	1870029	Yes
498	3171	3171.0	65.51	65.5	CpG-rich islands and the function of DNA methylation.	A P Bird	Nature	1986	2423876	No
499	3160	3160.0	75.67	75.7	Photoelectrochemical cells.	M Grätzel	Nature	2001	11713540	Yes
500	3152	3152.0	0.0	0.0	Diffusion-in-gel methods for immunological analysis.	O Ouchterlony	Prog Allergy	1958	13578996	Yes
501	3149	3149.0	63.26	63.3	The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited.	Isaiah J Fidler	Nat Rev Cancer	2003	12778135	No
502	9416	3138.7	243.66	81.2	Understanding the Warburg effect: the metabolic requirements of cell proliferation.	Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson	Science	2009	19460998	No
503	6261	3130.5	221.57	110.8	Management of hepatocellular carcinoma: an update.	Jordi Bruix, Morris Sherman	Hepatology	2011	21374666	No
504	3130	3130.0	0.0	0.0	Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.	S W Kessler	J Immunol	1975	1102604	Yes
505	3113	3113.0	65.17	65.2	Alzheimer's disease is a synaptic failure.	Dennis J Selkoe	Science	2002	12399581	No
506	3110	3110.0	73.67	73.7	WHAT IF: a molecular modeling and drug design program.	G Vriend	J Mol Graph	1990	2268628	Yes
507	6219	3109.5	260.03	130.0	The qualitative content analysis process.	Satu Elo, Helvi Kyngäs	J Adv Nurs	2008	18352969	Yes
508	3101	3101.0	97.28	97.3	Psychometric properties of the strengths and difficulties questionnaire.	R Goodman	J Am Acad Child Adolesc Psychiatry	2001	11699809	Yes
509	6189	3094.5	0.0	0.0	Superoxide dismutase: improved assays and an assay applicable to acrylamide gels.	C Beauchamp, I Fridovich	Anal Biochem	1971	4943714	Yes
510	6178	3089.0	247.99	124.0	Multiwfn: a multifunctional wavefunction analyzer.	Tian Lu, Feiwu Chen	J Comput Chem	2012	22162017	Yes
511	9242	3080.7	312.97	104.3	Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor.	R M Palmer, A G Ferrige, S Moncada	Nature	1987	3495737	Yes
512	3079	3079.0	94.47	94.5	Development of a classification system for periodontal diseases and conditions.	G C Armitage	Ann Periodontol	1999	10863370	No
513	3076	3076.0	65.55	65.5	Protein folding and misfolding.	Christopher M Dobson	Nature	2003	14685248	No
514	3062	3062.0	83.19	83.2	RELION: implementation of a Bayesian approach to cryo-EM structure determination.	Sjors H W Scheres	J Struct Biol	2012	23000701	Yes
515	6114	3057.0	171.35	85.7	Projections of global mortality and burden of disease from 2002 to 2030.	Colin D Mathers, Dejan Loncar	PLoS Med	2006	17132052	Yes
516	3055	3055.0	0.0	0.0	Gene action in the X-chromosome of the mouse (Mus musculus L.).	M F Lyon	Nature	1961	13764598	Yes
517	3054	3054.0	114.2	114.2	You want to measure coping but your protocol's too long: consider the brief COPE.	C S Carver	Int J Behav Med	1997	16250744	Yes
518	6100	3050.0	131.76	65.9	Toll-like receptor signalling.	Shizuo Akira, Kiyoshi Takeda	Nat Rev Immunol	2004	15229469	No
519	3048	3048.0	0.0	0.0	Transformed up-down methods in psychoacoustics.	H Levitt	J Acoust Soc Am	1971	5541744	Yes
520	3047	3047.0	65.64	65.6	Mechanisms of angiogenesis and arteriogenesis.	P Carmeliet	Nat Med	2000	10742145	No
521	3041	3041.0	137.72	137.7	The quality of care. How can it be assessed?	A Donabedian	JAMA	1988	3045356	No
522	3035	3035.0	65.4	65.4	Angiogenesis in health and disease.	Peter Carmeliet	Nat Med	2003	12778163	No
523	3028	3028.0	65.01	65.0	Cardiac excitation-contraction coupling.	Donald M Bers	Nature	2002	11805843	No
524	3026	3026.0	70.64	70.6	Cadherin cell adhesion receptors as a morphogenetic regulator.	M Takeichi	Science	1991	2006419	No
525	3025	3025.0	84.95	85.0	A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data.	Heng Li	Bioinformatics	2011	21903627	Yes
526	9073	3024.3	193.43	64.5	Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.	Benjamin P Lewis, Christopher B Burge, David P Bartel	Cell	2005	15652477	Yes
527	9067	3022.3	319.45	106.5	featureCounts: an efficient general purpose program for assigning sequence reads to genomic features.	Yang Liao, Gordon K Smyth, Wei Shi	Bioinformatics	2014	24227677	Yes
528	3020	3020.0	70.22	70.2	Mitochondrial formation of reactive oxygen species.	Julio F Turrens	J Physiol	2003	14561818	No
529	3011	3011.0	90.7	90.7	Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples.	Peter C Austin	Stat Med	2009	19757444	Yes
530	3010	3010.0	116.82	116.8	Half a century of research on the Stroop effect: an integrative review.	C M MacLeod	Psychol Bull	1991	2034749	No
531	9023	3007.7	376.88	125.6	HISAT: a fast spliced aligner with low memory requirements.	Daehwan Kim, Ben Langmead, Steven L Salzberg	Nat Methods	2015	25751142	Yes
532	6012	3006.0	137.02	68.5	MicroRNA signatures in human cancers.	George A Calin, Carlo M Croce	Nat Rev Cancer	2006	17060945	No
533	3004	3004.0	0.0	0.0	A study of fixation for electron microscopy.	G E Palade	J Exp Med	1952	14927794	Yes
534	2999	2999.0	0.0	0.0	Towards a network theory of the immune system.	N K Jerne	Ann Immunol (Paris)	1974	4142565	No
535	2999	2999.0	92.43	92.4	Accelerated Profile HMM Searches.	Sean R Eddy	PLoS Comput Biol	2011	22039361	Yes
536	2998	2998.0	72.07	72.1	Obesity as a medical problem.	P G Kopelman	Nature	2000	10766250	No
537	2997	2997.0	0.0	0.0	A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide.	S Hakomori	J Biochem	1964	14135466	Yes
538	5989	2994.5	0.0	0.0	Pain mechanisms: a new theory.	R Melzack, P D Wall	Science	1965	5320816	No
539	2993	2993.0	94.69	94.7	Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report.	Sarah E Barlow	Pediatrics	2007	18055651	Yes
540	2989	2989.0	98.16	98.2	Essential oils: their antibacterial properties and potential applications in foods--a review.	Sara Burt	Int J Food Microbiol	2004	15246235	No
541	5972	2986.0	153.01	76.5	Voxel-based morphometry--the methods.	J Ashburner, K J Friston	Neuroimage	2000	10860804	No
542	2981	2981.0	90.68	90.7	Hepatocellular carcinoma.	Hashem B El-Serag	N Engl J Med	2011	21992124	No
543	8932	2977.3	178.53	59.5	Significance analysis of microarrays applied to the ionizing radiation response.	V G Tusher, R Tibshirani, G Chu	Proc Natl Acad Sci U S A	2001	11309499	Yes
544	2975	2975.0	0.0	0.0	The gel-filtration behaviour of proteins related to their molecular weights over a wide range.	P Andrews	Biochem J	1965	5862401	Yes
545	5939	2969.5	125.46	62.7	Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.	D B Smith, K S Johnson	Gene	1988	3047011	Yes
546	2968	2968.0	75.22	75.2	Recent advances with liposomes as pharmaceutical carriers.	Vladimir P Torchilin	Nat Rev Drug Discov	2005	15688077	No
547	11863	2965.8	375.29	93.8	clusterProfiler: an R package for comparing biological themes among gene clusters.	Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu He	OMICS	2012	22455463	Yes
548	5931	2965.5	146.65	73.3	In vitro selection of RNA molecules that bind specific ligands.	A D Ellington, J W Szostak	Nature	1990	1697402	Yes
549	11853	2963.2	459.47	114.9	APACHE II: a severity of disease classification system.	W A Knaus, E A Draper, D P Wagner, J E Zimmerman	Crit Care Med	1985	3928249	Yes
550	2963	2963.0	0.0	0.0	Catheter replacement of the needle in percutaneous arteriography; a new technique.	S I Seldinger	Acta radiol	1953	13057644	Yes
551	5924	2962.0	106.45	53.2	The language of covalent histone modifications.	B D Strahl, C D Allis	Nature	2000	10638745	Yes
552	2960	2960.0	69.38	69.4	Chemokines--chemotactic cytokines that mediate inflammation.	A D Luster	N Engl J Med	1998	9459648	No
553	2953	2953.0	120.5	120.5	Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy.	T E Moffitt	Psychol Rev	1993	8255953	No
554	2948	2948.0	94.49	94.5	An empirical correction for absorption anisotropy.	R H Blessing	Acta Crystallogr A	1995	7702794	Yes
555	5883	2941.5	0.0	0.0	The serial cultivation of human diploid cell strains.	L Hayflick, P S Moorhead	Exp Cell Res	1961	13905658	Yes
556	5882	2941.0	191.56	95.8	The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM.	Stephen B Edge, Carolyn C Compton	Ann Surg Oncol	2010	20180029	No
557	5877	2938.5	0.0	0.0	A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.	S Reitman, S Frankel	Am J Clin Pathol	1957	13458125	Yes
558	2936	2936.0	90.76	90.8	Matrix metalloproteinases and their inhibitors in connective tissue remodeling.	J F Woessner	FASEB J	1991	1850705	No
559	5872	2936.0	195.39	97.7	Measuring agreement in method comparison studies.	J M Bland, D G Altman	Stat Methods Med Res	1999	10501650	No
560	2935	2935.0	101.88	101.9	The processing-speed theory of adult age differences in cognition.	T A Salthouse	Psychol Rev	1996	8759042	No
561	8803	2934.3	243.37	81.1	Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.	Y Gavrieli, Y Sherman, S A Ben-Sasson	J Cell Biol	1992	1400587	Yes
562	11687	2921.8	282.21	70.6	Haploview: analysis and visualization of LD and haplotype maps.	J C Barrett, B Fry, J Maller, M J Daly	Bioinformatics	2005	15297300	Yes
563	2920	2920.0	94.26	94.3	No adjustments are needed for multiple comparisons.	K J Rothman	Epidemiology	1990	2081237	Yes
564	2917	2917.0	83.5	83.5	Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection.	Y X Fu	Genetics	1997	9335623	Yes
565	2911	2911.0	54.96	55.0	RNA interference.	Gregory J Hannon	Nature	2002	12110901	No
566	2907	2907.0	0.0	0.0	Measurement of pain.	E C Huskisson	Lancet	1974	4139420	Yes
567	5807	2903.5	0.0	0.0	Assessment of outcome after severe brain damage.	B Jennett, M Bond	Lancet	1975	46957	Yes
568	5790	2895.0	138.59	69.3	Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.	T C Chou, P Talalay	Adv Enzyme Regul	1984	6382953	Yes
569	5787	2893.5	145.47	72.7	Exploring the full spectrum of macrophage activation.	David M Mosser, Justin P Edwards	Nat Rev Immunol	2008	19029990	No
570	2893	2893.0	64.36	64.4	TGFbeta in Cancer.	Joan Massagué	Cell	2008	18662538	No
571	5780	2890.0	162.85	81.4	Inositol trisphosphate, a novel second messenger in cellular signal transduction.	M J Berridge, R F Irvine	Nature	1984	6095092	No
572	5776	2888.0	180.48	90.2	mTOR signaling in growth control and disease.	Mathieu Laplante, David M Sabatini	Cell	2012	22500797	No
573	2887	2887.0	57.98	58.0	Toll-like receptors and innate immunity.	R Medzhitov	Nat Rev Immunol	2001	11905821	No
574	8655	2885.0	0.0	0.0	The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum.	R J Havel, H A Eder, J H Bragdon	J Clin Invest	1955	13252080	Yes
575	8641	2880.3	208.14	69.4	TopHat: discovering splice junctions with RNA-Seq.	Cole Trapnell, Lior Pachter, Steven L Salzberg	Bioinformatics	2009	19289445	Yes
576	2880	2880.0	51.32	51.3	One-step gene disruption in yeast.	R J Rothstein	Methods Enzymol	1983	6310324	Yes
577	2879	2879.0	71.94	71.9	The resurgence of platinum-based cancer chemotherapy.	Lloyd Kelland	Nat Rev Cancer	2007	17625587	No
578	5746	2873.0	188.08	94.0	Complex network measures of brain connectivity: uses and interpretations.	Mikail Rubinov, Olaf Sporns	Neuroimage	2010	19819337	Yes
579	2872	2872.0	60.16	60.2	Principles of CDK regulation.	D O Morgan	Nature	1995	7877684	No
580	2869	2869.0	70.37	70.4	Phase separation of integral membrane proteins in Triton X-114 solution.	C Bordier	J Biol Chem	1981	6257680	Yes
581	5737	2868.5	0.0	0.0	The fluid mosaic model of the structure of cell membranes.	S J Singer, G L Nicolson	Science	1972	4333397	Yes
582	2868	2868.0	0.0	0.0	Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method.	L Svennerholm	Biochim Biophys Acta	1957	13436486	Yes
583	5733	2866.5	174.09	87.0	Complex brain networks: graph theoretical analysis of structural and functional systems.	Ed Bullmore, Olaf Sporns	Nat Rev Neurosci	2009	19190637	No
584	5731	2865.5	158.63	79.3	The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.	Taro Kawai, Shizuo Akira	Nat Immunol	2010	20404851	No
585	2865	2865.0	54.62	54.6	Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling.	P Schuck	Biophys J	2000	10692345	Yes
586	5730	2865.0	131.17	65.6	Oxidants, oxidative stress and the biology of ageing.	T Finkel, N J Holbrook	Nature	2000	11089981	No
587	2862	2862.0	0.0	0.0	Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay.	B E Murphy	J Clin Endocrinol Metab	1967	4291524	Yes
588	5721	2860.5	182.23	91.1	Tissue engineering.	R Langer, J P Vacanti	Science	1993	8493529	No
589	2859	2859.0	87.95	88.0	adegenet: a R package for the multivariate analysis of genetic markers.	Thibaut Jombart	Bioinformatics	2008	18397895	Yes
590	2858	2858.0	95.43	95.4	DNA methylation age of human tissues and cell types.	Steve Horvath	Genome Biol	2013	24138928	Yes
591	2857	2857.0	130.51	130.5	The short-form McGill Pain Questionnaire.	Ronald Melzack	Pain	1987	3670870	Yes
592	2853	2853.0	72.95	73.0	Optimal two-stage designs for phase II clinical trials.	R Simon	Control Clin Trials	1989	2702835	Yes
593	8553	2851.0	0.0	0.0	Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane.	G Fairbanks, T L Steck, D F Wallach	Biochemistry	1971	4326772	Yes
594	2850	2850.0	0.0	0.0	Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid.	W C Schneider	J Biol Chem	1945	21005736	Yes
595	5699	2849.5	0.0	0.0	Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain.	J Glowinski, L L Iversen	J Neurochem	1966	5950056	Yes
596	5690	2845.0	0.0	0.0	Electrochemical photolysis of water at a semiconductor electrode.	A Fujishima, K Honda	Nature	1972	12635268	Yes
597	2844	2844.0	85.77	85.8	Implications of normal brain development for the pathogenesis of schizophrenia.	D R Weinberger	Arch Gen Psychiatry	1987	3606332	Yes
598	2842	2842.0	0.0	0.0	A study of the adrenotropic receptors.	R P Ahlquist	Am J Physiol	1948	18882199	Yes
599	2838	2838.0	95.04	95.0	Role of oxidative stress in development of complications in diabetes.	J W Baynes	Diabetes	1991	2010041	No
600	5673	2836.5	176.7	88.3	Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees.	K Tamura, M Nei	Mol Biol Evol	1993	8336541	Yes
601	2831	2831.0	0.0	0.0	A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples.	E A Gehan	Biometrika	1965	14341275	Yes
602	5656	2828.0	121.88	60.9	Emergence of scaling in random networks	Barabasi, Albert	Science	1999	10521342	Yes
603	8459	2819.7	278.85	93.0	Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases.	R A Deyo, D C Cherkin, M A Ciol	J Clin Epidemiol	1992	1607900	Yes
604	2815	2815.0	0.0	0.0	Notes on sugar determination.	M Smogyi	J Biol Chem	1952	14938350	Yes
605	2813	2813.0	61.46	61.5	Inflammatory bowel disease.	Daniel K Podolsky	N Engl J Med	2002	12167685	No
606	22498	2812.2	496.54	62.1	The Protein Data Bank.	H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E Bourne	Nucleic Acids Res	2000	10592235	Yes
607	2807	2807.0	67.14	67.1	Structure and function of telomeres.	E H Blackburn	Nature	1991	1708110	No
608	5614	2807.0	127.05	63.5	Oncomirs - microRNAs with a role in cancer.	Aurora Esquela-Kerscher, Frank J Slack	Nat Rev Cancer	2006	16557279	No
609	2805	2805.0	86.1	86.1	Estimation of metabolite concentrations from localized in vivo proton NMR spectra.	S W Provencher	Magn Reson Med	1993	8139448	Yes
610	5608	2804.0	246.43	123.2	Revised methods for the Salmonella mutagenicity test.	D M Maron, B N Ames	Mutat Res	1983	6341825	Yes
611	2804	2804.0	52.61	52.6	Genome maintenance mechanisms for preventing cancer.	J H Hoeijmakers	Nature	2001	11357144	No
612	2803	2803.0	0.0	0.0	Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism.	P Mitchell	Nature	1961	13771349	Yes
613	5605	2802.5	139.19	69.6	Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences.	Weizhong Li, Adam Godzik	Bioinformatics	2006	16731699	Yes
614	2801	2801.0	73.64	73.6	Cellular and molecular mechanisms of fibrosis.	T A Wynn	J Pathol	2008	18161745	No
615	11202	2800.5	370.92	92.7	A brief measure for assessing generalized anxiety disorder: the GAD-7.	Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd Löwe	Arch Intern Med	2006	16717171	Yes
616	2799	2799.0	104.25	104.2	The Danish Civil Registration System.	Carsten Bøcker Pedersen	Scand J Public Health	2011	21775345	Yes
617	2797	2797.0	102.56	102.6	Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM.	Joseph P Weir	J Strength Cond Res	2005	15705040	No
618	5590	2795.0	153.04	76.5	The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers.	J Vieira, J Messing	Gene	1982	6295879	Yes
619	8380	2793.3	242.23	80.7	Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study.	G Evanno, S Regnaut, J Goudet	Mol Ecol	2005	15969739	Yes
620	11144	2786.0	0.0	0.0	Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.	P W Rigby, M Dieckmann, C Rhodes, P Berg	J Mol Biol	1977	881736	Yes
621	5570	2785.0	0.0	0.0	A method for determining the sedimentation behavior of enzymes: application to protein mixtures.	R G Martin, B N Ames	J Biol Chem	1961	13767412	Yes
622	5561	2780.5	127.73	63.9	Caspases: enemies within.	N A Thornberry, Y Lazebnik	Science	1998	9721091	No
623	2780	2780.0	0.0	0.0	Efficient trace-labelling of proteins with iodine.	A S McFARLANE	Nature	1958	13566175	Yes
624	8333	2777.7	192.2	64.1	The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.	R C Lee, R L Feinbaum, V Ambros	Cell	1993	8252621	Yes
625	5555	2777.5	143.46	71.7	Long short-term memory.	S Hochreiter, J Schmidhuber	Neural Comput	1997	9377276	Yes
626	2770	2770.0	0.0	0.0	A gene complex controlling segmentation in Drosophila.	E B Lewis	Nature	1978	103000	Yes
627	2763	2763.0	63.97	64.0	Autophagy: process and function.	Noboru Mizushima	Genes Dev	2007	18006683	No
628	2763	2763.0	98.54	98.5	What is value in health care?	Michael E Porter	N Engl J Med	2010	21142528	Yes
629	2762	2762.0	0.0	0.0	The genetical structure of populations.	S Wright	Ann Eugen	1951	24540312	Yes
630	2760	2760.0	65.03	65.0	Molecular chaperones in cellular protein folding.	F U Hartl	Nature	1996	8637592	No
631	11018	2754.5	352.04	88.0	Cancer statistics, 2010.	Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth Ward	CA Cancer J Clin	2010	20610543	Yes
632	2749	2749.0	0.0	0.0	Analysis of gene diversity in subdivided populations.	M Nei	Proc Natl Acad Sci U S A	1973	4519626	Yes
633	2747	2747.0	60.53	60.5	Nuclear factor-kappaB in cancer development and progression.	Michael Karin	Nature	2006	16724054	No
634	5490	2745.0	108.87	54.4	High-efficiency transformation of mammalian cells by plasmid DNA.	C Chen, H Okayama	Mol Cell Biol	1987	3670292	Yes
635	2744	2744.0	66.59	66.6	Cell death during development of the nervous system.	R W Oppenheim	Annu Rev Neurosci	1991	2031577	No
636	8218	2739.3	177.68	59.2	Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.	C M Gorman, L F Moffat, B H Howard	Mol Cell Biol	1982	6960240	Yes
637	2735	2735.0	83.66	83.7	Primate models of movement disorders of basal ganglia origin.	M R DeLong	Trends Neurosci	1990	1695404	No
638	2735	2735.0	55.02	55.0	Papillomaviruses and cancer: from basic studies to clinical application.	Harald zur Hausen	Nat Rev Cancer	2002	12044010	No
639	2731	2731.0	0.0	0.0	Stereotaxic mapping of the monoamine pathways in the rat brain.	U Ungerstedt	Acta Physiol Scand Suppl	1971	4109331	Yes
640	5461	2730.5	191.4	95.7	A method of comparing the areas under receiver operating characteristic curves derived from the same cases.	J A Hanley, B J McNeil	Radiology	1983	6878708	Yes
641	5460	2730.0	0.0	0.0	A modified uronic acid carbazole reaction.	T Bitter, H M Muir	Anal Biochem	1962	13971270	Yes
642	5455	2727.5	129.62	64.8	Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes.	F W Studier, B A Moffatt	J Mol Biol	1986	3537305	Yes
643	5449	2724.5	116.28	58.1	Inflammation and cancer: back to Virchow?	F Balkwill, A Mantovani	Lancet	2001	11229684	No
644	2724	2724.0	54.83	54.8	Interleukin-12 and the regulation of innate resistance and adaptive immunity.	Giorgio Trinchieri	Nat Rev Immunol	2003	12563297	No
645	2722	2722.0	96.59	96.6	Measures of reliability in sports medicine and science.	W G Hopkins	Sports Med	2000	10907753	Yes
646	5438	2719.0	110.81	55.4	Establishment in culture of pluripotential cells from mouse embryos.	M J Evans, M H Kaufman	Nature	1981	7242681	Yes
647	5437	2718.5	133.44	66.7	Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis.	D Hanahan, J Folkman	Cell	1996	8756718	No
648	2712	2712.0	0.0	0.0	A simple technique for demonstrating centromeric heterochromatin.	A T Sumner	Exp Cell Res	1972	4117921	Yes
649	2711	2711.0	0.0	0.0	Elastic properties of lipid bilayers: theory and possible experiments.	W Helfrich	Z Naturforsch C	1973	4273690	Yes
650	2708	2708.0	46.77	46.8	Mechanisms underlying ubiquitination.	C M Pickart	Annu Rev Biochem	2001	11395416	No
651	5410	2705.0	166.11	83.1	Glutathione.	A Meister, M E Anderson	Annu Rev Biochem	1983	6137189	No
652	8115	2705.0	204.96	68.3	MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment.	Sudhir Kumar, Koichiro Tamura, Masatoshi Nei	Brief Bioinform	2004	15260895	Yes
653	5405	2702.5	174.96	87.5	Computed tomography--an increasing source of radiation exposure.	David J Brenner, Eric J Hall	N Engl J Med	2007	18046031	No
654	5384	2692.0	108.94	54.5	Innate immune recognition.	Charles A Janeway, Ruslan Medzhitov	Annu Rev Immunol	2002	11861602	No
655	5372	2686.0	144.98	72.5	Unified segmentation.	John Ashburner, Karl J Friston	Neuroimage	2005	15955494	Yes
656	8051	2683.7	155.47	51.8	Gene Expression Omnibus: NCBI gene expression and hybridization array data repository.	Ron Edgar, Michael Domrachev, Alex E Lash	Nucleic Acids Res	2002	11752295	Yes
657	5363	2681.5	0.0	0.0	Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent.	J Sedlak, R H Lindsay	Anal Biochem	1968	4973948	Yes
658	2680	2680.0	53.31	53.3	The danger model: a renewed sense of self.	Polly Matzinger	Science	2002	11951032	Yes
659	2672	2672.0	122.5	122.5	Detecting alcoholism. The CAGE questionnaire.	J A Ewing	JAMA	1984	6471323	Yes
660	2666	2666.0	0.0	0.0	Colorimetric assay of catalase.	A K Sinha	Anal Biochem	1972	4556490	Yes
661	10645	2661.2	229.15	57.3	Cluster analysis and display of genome-wide expression patterns.	M B Eisen, P T Spellman, P O Brown, D Botstein	Proc Natl Acad Sci U S A	1998	9843981	Yes
662	2661	2661.0	60.83	60.8	Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays.	S A Bustin	J Mol Endocrinol	2000	11013345	No
663	2658	2658.0	63.59	63.6	MapChart: software for the graphical presentation of linkage maps and QTLs.	R E Voorrips	J Hered	2002	12011185	Yes
664	2657	2657.0	60.49	60.5	Cell adhesion: the molecular basis of tissue architecture and morphogenesis.	B M Gumbiner	Cell	1996	8608588	No
665	5309	2654.5	193.34	96.7	Longitudinal data analysis for discrete and continuous outcomes.	S L Zeger, K Y Liang	Biometrics	1986	3719049	Yes
666	13272	2654.4	1115.94	223.2	MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms.	Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro Tamura	Mol Biol Evol	2018	29722887	Yes
667	2653	2653.0	69.48	69.5	Predictive reward signal of dopamine neurons.	W Schultz	J Neurophysiol	1998	9658025	No
668	2652	2652.0	0.0	0.0	Models for the specific adhesion of cells to cells.	G I Bell	Science	1978	347575	No
669	2651	2651.0	0.0	0.0	Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads.	P Cuatrecasas	J Biol Chem	1970	5432796	Yes
670	2651	2651.0	0.0	0.0	Perceived exertion as an indicator of somatic stress.	G Borg	Scand J Rehabil Med	1970	5523831	Yes
671	7947	2649.0	186.5	62.2	Pathogen recognition and innate immunity.	Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi	Cell	2006	16497588	No
672	5285	2642.5	241.2	120.6	GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update.	Rod Peakall, Peter E Smouse	Bioinformatics	2012	22820204	Yes
673	2642	2642.0	67.94	67.9	The genetic legacy of the Quaternary ice ages.	G Hewitt	Nature	2000	10879524	No
674	2642	2642.0	52.1	52.1	Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses.	Shimon Sakaguchi	Annu Rev Immunol	2004	15032588	No
675	5282	2641.0	144.19	72.1	Pattern recognition receptors and inflammation.	Osamu Takeuchi, Shizuo Akira	Cell	2010	20303872	No
676	2640	2640.0	59.78	59.8	Salt and drought stress signal transduction in plants.	Jian-Kang Zhu	Annu Rev Plant Biol	2002	12221975	No
677	2636	2636.0	62.12	62.1	Memory--a century of consolidation.	J L McGaugh	Science	2000	10634773	No
678	2634	2634.0	61.44	61.4	Calcium signaling.	David E Clapham	Cell	2007	18083096	No
679	5262	2631.0	0.0	0.0	Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase.	S Marklund, G Marklund	Eur J Biochem	1974	4215654	Yes
680	5262	2631.0	149.02	74.5	Adherence to medication.	Lars Osterberg, Terrence Blaschke	N Engl J Med	2005	16079372	No
681	5253	2626.5	0.0	0.0	The Social Readjustment Rating Scale.	T H Holmes, R H Rahe	J Psychosom Res	1967	6059863	Yes
682	5241	2620.5	0.0	0.0	Some quantitative uses of drug antagonists.	O Arunlakshana, H O Schild	Br J Pharmacol Chemother	1959	13651579	Yes
683	2616	2616.0	82.14	82.1	Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.	B Samuelsson	Science	1983	6301011	Yes
684	10461	2615.2	318.2	79.5	Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy.	Qiong Wang, George M Garrity, James M Tiedje, James R Cole	Appl Environ Microbiol	2007	17586664	Yes
685	2615	2615.0	65.42	65.4	The nerve growth factor 35 years later.	R Levi-Montalcini	Science	1987	3306916	No
686	7841	2613.7	411.27	137.1	Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition.	P J Van Soest, J B Robertson, B A Lewis	J Dairy Sci	1991	1660498	No
687	2613	2613.0	57.33	57.3	Bone resorption by osteoclasts.	S L Teitelbaum	Science	2000	10968780	No
688	2612	2612.0	0.0	0.0	A Rationale And Test For The Number Of Factors In Factor Analysis.	J L Horn	Psychometrika	1965	14306381	Yes
689	2611	2611.0	59.71	59.7	Prostaglandins and leukotrienes: advances in eicosanoid biology.	C D Funk	Science	2001	11729303	No
690	5218	2609.0	117.52	58.8	Signal transduction by receptors with tyrosine kinase activity.	A Ullrich, J Schlessinger	Cell	1990	2158859	No
691	2609	2609.0	62.51	62.5	Modularity and community structure in networks.	M E J Newman	Proc Natl Acad Sci U S A	2006	16723398	Yes
692	5218	2609.0	125.49	62.7	Autophagy in the pathogenesis of disease.	Beth Levine, Guido Kroemer	Cell	2008	18191218	No
693	2609	2609.0	73.35	73.3	The nuclear factor NF-kappaB pathway in inflammation.	Toby Lawrence	Cold Spring Harb Perspect Biol	2009	20457564	No
694	5217	2608.5	0.0	0.0	Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.	L A Greene, A S Tischler	Proc Natl Acad Sci U S A	1976	1065897	Yes
695	5214	2607.0	181.28	90.6	A simple, rapid, and sensitive DNA assay procedure.	C Labarca, K Paigen	Anal Biochem	1980	6158890	Yes
696	2605	2605.0	0.0	0.0	The biology of oxygen radicals.	I Fridovich	Science	1978	210504	Yes
697	2605	2605.0	81.68	81.7	What are the functional consequences of neurocognitive deficits in schizophrenia?	M F Green	Am J Psychiatry	1996	8610818	No
698	5199	2599.5	165.09	82.5	Accurate and simple analytic representation of the electron-gas correlation energy.	Perdew, Wang	Phys Rev B Condens Matter	1992	10001404	Yes
699	10391	2597.8	311.79	77.9	Establishing a standard definition for child overweight and obesity worldwide: international survey.	T J Cole, M C Bellizzi, K M Flegal, W H Dietz	BMJ	2000	10797032	Yes
700	2596	2596.0	0.0	0.0	On the number of segregating sites in genetical models without recombination.	G A Watterson	Theor Popul Biol	1975	1145509	Yes
701	2595	2595.0	0.0	0.0	The membrane actions of anesthetics and tranquilizers.	P Seeman	Pharmacol Rev	1972	4565956	No
702	2594	2594.0	47.01	47.0	Automated electron microscope tomography using robust prediction of specimen movements.	David N Mastronarde	J Struct Biol	2005	16182563	Yes
703	7782	2594.0	198.8	66.3	ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data.	Kai Wang, Mingyao Li, Hakon Hakonarson	Nucleic Acids Res	2010	20601685	Yes
704	2588	2588.0	55.8	55.8	G1 phase progression: cycling on cue.	C J Sherr	Cell	1994	7954821	No
705	2581	2581.0	0.0	0.0	Satellite cell of skeletal muscle fibers.	A Mauro	J Biophys Biochem Cytol	1961	13768451	Yes
706	23205	2578.3	506.08	56.2	Cytoscape: a software environment for integrated models of biomolecular interaction networks.	Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey Ideker	Genome Res	2003	14597658	Yes
707	2576	2576.0	0.0	0.0	The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.	R R Porter	Biochem J	1959	14434282	Yes
708	2573	2573.0	62.48	62.5	Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity.	E C Butcher	Cell	1991	1760836	No
709	2564	2564.0	0.0	0.0	Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults.	O Smithies	Biochem J	1955	13276348	Yes
710	5127	2563.5	205.38	102.7	A feature-integration theory of attention.	A M Treisman, G Gelade	Cogn Psychol	1980	7351125	Yes
711	2562	2562.0	73.08	73.1	Delayed neuronal death in the gerbil hippocampus following ischemia.	T Kirino	Brain Res	1982	7093691	Yes
712	2559	2559.0	69.93	69.9	Accurate Coulomb-fitting basis sets for H to Rn.	Florian Weigend	Phys Chem Chem Phys	2006	16633586	Yes
713	5117	2558.5	159.6	79.8	The L-arginine-nitric oxide pathway.	S Moncada, A Higgs	N Engl J Med	1993	7504210	No
714	2542	2542.0	58.78	58.8	Vascular endothelial growth factor: basic science and clinical progress.	Napoleone Ferrara	Endocr Rev	2004	15294883	No
715	5072	2536.0	0.0	0.0	Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid.	J D Watson, F H Crick	Nature	1953	13054692	Yes
716	2536	2536.0	75.13	75.1	Efficient methods to compute genomic predictions.	P M VanRaden	J Dairy Sci	2008	18946147	Yes
717	2532	2532.0	0.0	0.0	The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin.	M L Anson	J Gen Physiol	1938	19873094	Yes
718	2531	2531.0	67.49	67.5	The magical number 4 in short-term memory: a reconsideration of mental storage capacity.	N Cowan	Behav Brain Sci	2001	11515286	Yes
719	2530	2530.0	65.22	65.2	Dietary pattern analysis: a new direction in nutritional epidemiology.	Frank B Hu	Curr Opin Lipidol	2002	11790957	No
720	2529	2529.0	0.0	0.0	The catecholamine hypothesis of affective disorders: a review of supporting evidence.	J J Schildkraut	Am J Psychiatry	1965	5319766	No
721	2528	2528.0	46.01	46.0	Wnt signaling and cancer.	P Polakis	Genes Dev	2000	10921899	No
722	2526	2526.0	77.57	77.6	Secretory products of macrophages.	C F Nathan	J Clin Invest	1987	3543052	No
723	7572	2524.0	332.41	110.8	Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale.	J L Cox, J M Holden, R Sagovsky	Br J Psychiatry	1987	3651732	Yes
724	2524	2524.0	59.34	59.3	Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface.	G P Smith	Science	1985	4001944	Yes
725	5048	2524.0	105.54	52.8	MicroRNAs: small RNAs with a big role in gene regulation.	Lin He, Gregory J Hannon	Nat Rev Genet	2004	15211354	No
726	5047	2523.5	100.24	50.1	Untangling the ErbB signalling network.	Y Yarden, M X Sliwkowski	Nat Rev Mol Cell Biol	2001	11252954	No
727	2523	2523.0	72.94	72.9	Formation and Structure of Self-Assembled Monolayers.	Abraham Ulman	Chem Rev	1996	11848802	Yes
728	2521	2521.0	50.87	50.9	Universal control mechanism regulating onset of M-phase.	P Nurse	Nature	1990	2138713	No
729	2517	2517.0	0.0	0.0	The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes.	S Boyden	J Exp Med	1962	13872176	Yes
730	5031	2515.5	0.0	0.0	A diagnostic interview: the schedule for affective disorders and schizophrenia.	J Endicott, R L Spitzer	Arch Gen Psychiatry	1978	678037	Yes
731	2511	2511.0	67.41	67.4	Dominant forces in protein folding.	K A Dill	Biochemistry	1990	2207096	No
732	2506	2506.0	57.18	57.2	Epigenetics in cancer.	Manel Esteller	N Engl J Med	2008	18337604	No
733	5007	2503.5	163.66	81.8	The neural basis of drug craving: an incentive-sensitization theory of addiction.	T E Robinson, K C Berridge	Brain Res Brain Res Rev	1993	8401595	No
734	2500	2500.0	61.82	61.8	Cancer nanotechnology: opportunities and challenges.	Mauro Ferrari	Nat Rev Cancer	2005	15738981	No
735	4992	2496.0	0.0	0.0	Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.	P J Fraker, J C Speck	Biochem Biophys Res Commun	1978	637870	Yes
736	4987	2493.5	186.57	93.3	The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories.	P F Lovibond, S H Lovibond	Behav Res Ther	1995	7726811	Yes
737	4981	2490.5	172.32	86.2	The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions.	S H Downs, N Black	J Epidemiol Community Health	1998	9764259	Yes
738	4980	2490.0	0.0	0.0	A general method applicable to the search for similarities in the amino acid sequence of two proteins.	S B Needleman, C D Wunsch	J Mol Biol	1970	5420325	Yes
739	2490	2490.0	76.55	76.5	SF-36 health survey update.	J E Ware	Spine (Phila Pa 1976)	2000	11124729	No
740	4977	2488.5	159.51	79.8	Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being.	R M Ryan, E L Deci	Am Psychol	2000	11392867	Yes
741	2486	2486.0	61.3	61.3	Molecular basis of bacterial outer membrane permeability revisited.	Hiroshi Nikaido	Microbiol Mol Biol Rev	2003	14665678	No
742	4969	2484.5	153.11	76.6	Rapid isolation of high molecular weight plant DNA.	M G Murray, W F Thompson	Nucleic Acids Res	1980	7433111	Yes
743	2483	2483.0	0.0	0.0	Oxygen-dependent microbial killing by phagocytes (first of two parts).	B M Babior	N Engl J Med	1978	24176	Yes
744	2479	2479.0	101.68	101.7	Qualitative research. Introducing focus groups.	J Kitzinger	BMJ	1995	7633241	Yes
745	2478	2478.0	49.68	49.7	Tumour-educated macrophages promote tumour progression and metastasis.	Jeffrey W Pollard	Nat Rev Cancer	2004	14708027	No
746	2476	2476.0	72.38	72.4	Parkinson's disease: clinical features and diagnosis.	J Jankovic	J Neurol Neurosurg Psychiatry	2008	18344392	No
747	4951	2475.5	242.5	121.2	Stress, social support, and the buffering hypothesis.	S Cohen, T A Wills	Psychol Bull	1985	3901065	No
748	2471	2471.0	52.51	52.5	Evolving concepts of rheumatoid arthritis.	Gary S Firestein	Nature	2003	12748655	No
749	2468	2468.0	54.83	54.8	Angiogenesis in life, disease and medicine.	Peter Carmeliet	Nature	2005	16355210	No
750	9866	2466.5	376.33	94.1	Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses.	Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg Lang	Behav Res Methods	2009	19897823	Yes
751	4926	2463.0	0.0	0.0	Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion.	J Silness, H Loe	Acta Odontol Scand	1964	14158464	Yes
752	9846	2461.5	434.23	108.6	Cancer statistics, 2014.	Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin Jemal	CA Cancer J Clin	2014	24399786	Yes
753	4921	2460.5	0.0	0.0	Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years.	J V Durnin, J Womersley	Br J Nutr	1974	4843734	Yes
754	4898	2449.0	118.56	59.3	Calculation of protein extinction coefficients from amino acid sequence data.	S C Gill, P H von Hippel	Anal Biochem	1989	2610349	Yes
755	2446	2446.0	54.8	54.8	Social controls on cell survival and cell death.	M C Raff	Nature	1992	1557121	No
756	4888	2444.0	96.28	48.1	CDK inhibitors: positive and negative regulators of G1-phase progression.	C J Sherr, J M Roberts	Genes Dev	1999	10385618	No
757	2440	2440.0	69.3	69.3	Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention.	P Correa	Cancer Res	1992	1458460	No
758	14635	2439.2	338.07	56.3	Phaser crystallographic software.	Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J Read	J Appl Crystallogr	2007	19461840	Yes
759	2436	2436.0	0.0	0.0	Transduction of linked genetic characters of the host by bacteriophage P1.	E S Lennox	Virology	1955	13267987	Yes
760	2422	2422.0	104.47	104.5	Microplastics in the marine environment.	Anthony L Andrady	Mar Pollut Bull	2011	21742351	No
761	2419	2419.0	65.59	65.6	Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication.	H G Gratzner	Science	1982	7123245	Yes
762	2416	2416.0	50.79	50.8	Telomere measurement by quantitative PCR.	Richard M Cawthon	Nucleic Acids Res	2002	12000852	Yes
763	4819	2409.5	175.88	87.9	Extracellular vesicles: exosomes, microvesicles, and friends.	Graça Raposo, Willem Stoorvogel	J Cell Biol	2013	23420871	No
764	2407	2407.0	46.98	47.0	Getting started with yeast.	F Sherman	Methods Enzymol	1991	2005794	Yes
765	4801	2400.5	97.96	49.0	Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.	D Bonnet, J E Dick	Nat Med	1997	9212098	Yes
766	2396	2396.0	68.4	68.4	Physiology and neurobiology of stress and adaptation: central role of the brain.	Bruce S McEwen	Physiol Rev	2007	17615391	No
767	2394	2394.0	74.39	74.4	The unfolded protein response: controlling cell fate decisions under ER stress and beyond.	Claudio Hetz	Nat Rev Mol Cell Biol	2012	22251901	No
768	4776	2388.0	146.06	73.0	Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections.	Jeng-Da Chai, Martin Head-Gordon	Phys Chem Chem Phys	2008	18989472	Yes
769	2388	2388.0	84.25	84.2	A computational approach to edge detection.	J Canny	IEEE Trans Pattern Anal Mach Intell	1986	21869365	Yes
770	26264	2387.6	557.91	50.7	Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.	Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P Mesirov	Proc Natl Acad Sci U S A	2005	16199517	Yes
771	7143	2381.0	182.72	60.9	Canonical sampling through velocity rescaling.	Giovanni Bussi, Davide Donadio, Michele Parrinello	J Chem Phys	2007	17212484	Yes
772	4754	2377.0	120.04	60.0	Reactive oxygen species: metabolism, oxidative stress, and signal transduction.	Klaus Apel, Heribert Hirt	Annu Rev Plant Biol	2004	15377225	No
773	2376	2376.0	97.78	97.8	Central sensitization: implications for the diagnosis and treatment of pain.	Clifford J Woolf	Pain	2011	20961685	No
774	2376	2376.0	59.98	60.0	T cell exhaustion.	E John Wherry	Nat Immunol	2011	21739672	No
775	2375	2375.0	58.52	58.5	Causes and consequences of microRNA dysregulation in cancer.	Carlo M Croce	Nat Rev Genet	2009	19763153	No
776	2374	2374.0	51.95	52.0	Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling.	T Hunter	Cell	1995	7834742	No
777	2372	2372.0	0.0	0.0	The glomerular permeability determined by dextran clearance using Sephadex gel filtration.	C E Mogensen	Scand J Clin Lab Invest	1968	5637478	Yes
778	2372	2372.0	59.23	59.2	A mechanism for cognitive dynamics: neuronal communication through neuronal coherence.	Pascal Fries	Trends Cogn Sci	2005	16150631	No
779	2371	2371.0	0.0	0.0	Electroimmuno assay.	C B Laurell	Scand J Clin Lab Invest Suppl	1972	4114358	Yes
780	2369	2369.0	0.0	0.0	A rapid radiochemical method for the determination of choline acetyltransferase.	F Fonnum	J Neurochem	1975	1113118	Yes
781	2363	2363.0	69.11	69.1	Stress, adaptation, and disease. Allostasis and allostatic load.	B S McEwen	Ann N Y Acad Sci	1998	9629234	No
782	4714	2357.0	92.63	46.3	The phosphatidylinositol 3-Kinase AKT pathway in human cancer.	Igor Vivanco, Charles L Sawyers	Nat Rev Cancer	2002	12094235	No
783	2352	2352.0	67.2	67.2	Two-sided confidence intervals for the single proportion: comparison of seven methods.	R G Newcombe	Stat Med	1998	9595616	Yes
784	4697	2348.5	0.0	0.0	Screening lambdagt recombinant clones by hybridization to single plaques in situ.	W D Benton, R W Davis	Science	1977	322279	Yes
785	4695	2347.5	93.9	47.0	Lipid rafts and signal transduction.	K Simons, D Toomre	Nat Rev Mol Cell Biol	2000	11413487	No
786	2345	2345.0	0.0	0.0	Evaluating the quality of medical care.	A Donabedian	Milbank Mem Fund Q	1966	5338568	No
787	2344	2344.0	0.0	0.0	The Michigan alcoholism screening test: the quest for a new diagnostic instrument.	M L Selzer	Am J Psychiatry	1971	5565851	Yes
788	4686	2343.0	104.42	52.2	Death receptors: signaling and modulation.	A Ashkenazi, V M Dixit	Science	1998	9721089	No
789	2341	2341.0	53.7	53.7	A decade of molecular biology of retinoic acid receptors.	P Chambon	FASEB J	1996	8801176	No
790	2337	2337.0	85.24	85.2	Calmodulin plays a pivotal role in cellular regulation.	W Y Cheung	Science	1980	6243188	No
791	2336	2336.0	94.34	94.3	Role of nrf2 in oxidative stress and toxicity.	Qiang Ma	Annu Rev Pharmacol Toxicol	2013	23294312	No
792	2332	2332.0	49.49	49.5	Molecular physiology of P2X receptors.	R Alan North	Physiol Rev	2002	12270951	No
793	6993	2331.0	182.06	60.7	RNA-Seq: a revolutionary tool for transcriptomics.	Zhong Wang, Mark Gerstein, Michael Snyder	Nat Rev Genet	2009	19015660	No
794	6989	2329.7	195.46	65.2	Quantum mechanical continuum solvation models.	Jacopo Tomasi, Benedetta Mennucci, Roberto Cammi	Chem Rev	2005	16092826	Yes
795	4659	2329.5	121.76	60.9	Management of hepatocellular carcinoma.	Jordi Bruix, Morris Sherman	Hepatology	2005	16250051	No
796	9314	2328.5	253.41	63.4	GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation.	Berk Hess, Carsten Kutzner, David van der Spoel, Erik Lindahl	J Chem Theory Comput	2008	26620784	Yes
797	2325	2325.0	52.11	52.1	The structure and regulation of protein phosphatases.	P Cohen	Annu Rev Biochem	1989	2549856	No
798	6971	2323.7	201.49	67.2	Bacterial biofilms: a common cause of persistent infections.	J W Costerton, P S Stewart, E P Greenberg	Science	1999	10334980	No
799	4647	2323.5	0.0	0.0	Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography.	R A Laskey, A D Mills	Eur J Biochem	1975	1175627	Yes
800	2323	2323.0	0.0	0.0	The information capacity of the human motor system in controlling the amplitude of movement.	P M Fitts	J Exp Psychol	1954	13174710	Yes
801	4644	2322.0	106.44	53.2	Signal integration in the endoplasmic reticulum unfolded protein response.	David Ron, Peter Walter	Nat Rev Mol Cell Biol	2007	17565364	No
802	2318	2318.0	60.1	60.1	Immunological and inflammatory functions of the interleukin-1 family.	Charles A Dinarello	Annu Rev Immunol	2009	19302047	No
803	4634	2317.0	0.0	0.0	Periodontal Disease In Pregnancy. I. Prevalence And Severity.	H Loe, J Silness	Acta Odontol Scand	1963	14121956	Yes
804	2316	2316.0	0.0	0.0	Muscle structure and theories of contraction.	A F Huxley	Prog Biophys Biophys Chem	1957	13485191	Yes
805	6946	2315.3	0.0	0.0	On The Nature Of Allosteric Transitions: A Plausible Model.	J Monod, J Wyman, J P Changeux	J Mol Biol	1965	14343300	Yes
806	4629	2314.5	140.5	70.2	SPSS and SAS procedures for estimating indirect effects in simple mediation models.	Kristopher J Preacher, Andrew F Hayes	Behav Res Methods Instrum Comput	2004	15641418	Yes
807	4627	2313.5	112.45	56.2	Myeloid-derived suppressor cells as regulators of the immune system.	Dmitry I Gabrilovich, Srinivas Nagaraj	Nat Rev Immunol	2009	19197294	No
808	2312	2312.0	0.0	0.0	Inositol phospholipids and cell surface receptor function.	R H Michell	Biochim Biophys Acta	1975	164246	No
809	2311	2311.0	0.0	0.0	Application of a microtechnique to viral serological investigations.	J L Sever	J Immunol	1962	13910995	Yes
810	2308	2308.0	51.78	51.8	Mitochondrial diseases in man and mouse.	D C Wallace	Science	1999	10066162	No
811	2307	2307.0	66.31	66.3	Interleukin-1 and interleukin-1 antagonism.	C A Dinarello	Blood	1991	1826616	No
812	2303	2303.0	57.22	57.2	Bcl-2 and the regulation of programmed cell death.	J C Reed	J Cell Biol	1994	8294493	No
813	2302	2302.0	0.0	0.0	Stereochemistry of cooperative effects in haemoglobin.	M F Perutz	Nature	1970	5528785	Yes
814	4602	2301.0	97.37	48.7	New functions for the matrix metalloproteinases in cancer progression.	Mikala Egeblad, Zena Werb	Nat Rev Cancer	2002	11990853	No
815	4600	2300.0	138.03	69.0	Neural mechanisms of selective visual attention.	R Desimone, J Duncan	Annu Rev Neurosci	1995	7605061	No
816	2300	2300.0	42.99	43.0	Java Treeview--extensible visualization of microarray data.	Alok J Saldanha	Bioinformatics	2004	15180930	Yes
817	6890	2296.7	191.15	63.7	Immunity, inflammation, and cancer.	Sergei I Grivennikov, Florian R Greten, Michael Karin	Cell	2010	20303878	No
818	2296	2296.0	57.37	57.4	A model for receptor-regulated calcium entry.	J W Putney	Cell Calcium	1986	2420465	No
819	2296	2296.0	60.81	60.8	A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.	P Chomczynski	Biotechniques	1993	7692896	Yes
820	2296	2296.0	43.1	43.1	Targeting RAS signalling pathways in cancer therapy.	Julian Downward	Nat Rev Cancer	2003	12509763	No
821	2296	2296.0	49.21	49.2	Cisplatin: mode of cytotoxic action and molecular basis of resistance.	Zahid H Siddik	Oncogene	2003	14576837	No
822	4589	2294.5	86.95	43.5	A novel genetic system to detect protein-protein interactions.	S Fields, O Song	Nature	1989	2547163	Yes
823	4586	2293.0	0.0	0.0	High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.	M N Berry, D S Friend	J Cell Biol	1969	4900611	Yes
824	4584	2292.0	119.41	59.7	Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology.	Marie-Christine Daniel, Didier Astruc	Chem Rev	2004	14719978	No
825	2291	2291.0	0.0	0.0	A rating instrument for anxiety disorders.	W W Zung	Psychosomatics	1971	5172928	Yes
826	6860	2286.7	153.75	51.2	The biology of VEGF and its receptors.	Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter	Nat Med	2003	12778165	No
827	4566	2283.0	203.46	101.7	Clinical significance: a statistical approach to defining meaningful change in psychotherapy research.	N S Jacobson, P Truax	J Consult Clin Psychol	1991	2002127	Yes
828	4565	2282.5	115.2	57.6	A global optimisation method for robust affine registration of brain images.	M Jenkinson, S Smith	Med Image Anal	2001	11516708	Yes
829	2282	2282.0	45.61	45.6	SV40-transformed simian cells support the replication of early SV40 mutants.	Y Gluzman	Cell	1981	6260373	Yes
830	4559	2279.5	150.67	75.3	Random-effects models for longitudinal data.	N M Laird, J H Ware	Biometrics	1982	7168798	Yes
831	2279	2279.0	73.5	73.5	The free-energy principle: a unified brain theory?	Karl Friston	Nat Rev Neurosci	2010	20068583	No
832	4553	2276.5	116.92	58.5	The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.	Karen Bedard, Karl-Heinz Krause	Physiol Rev	2007	17237347	No
833	2276	2276.0	55.96	56.0	The anatomy and taxonomy of protein structure.	J S Richardson	Adv Protein Chem	1981	7020376	No
834	2275	2275.0	50.63	50.6	A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine.	Douglas C Wallace	Annu Rev Genet	2005	16285865	No
835	4550	2275.0	121.01	60.5	UniFrac: a new phylogenetic method for comparing microbial communities.	Catherine Lozupone, Rob Knight	Appl Environ Microbiol	2005	16332807	Yes
836	4548	2274.0	0.0	0.0	On the size of the active site in proteases. I. Papain.	I Schechter, A Berger	Biochem Biophys Res Commun	1967	6035483	Yes
837	2273	2273.0	76.36	76.4	Glutamate, nitric oxide and cell-cell signalling in the nervous system.	J Garthwaite	Trends Neurosci	1991	1708538	No
838	2271	2271.0	71.9	71.9	Reactive oxygen species and the central nervous system.	B Halliwell	J Neurochem	1992	1402908	No
839	2271	2271.0	54.93	54.9	Ischemic cell death in brain neurons.	P Lipton	Physiol Rev	1999	10508238	No
840	2271	2271.0	65.6	65.6	Scaffolds in tissue engineering bone and cartilage.	D W Hutmacher	Biomaterials	2000	11071603	Yes
841	2270	2270.0	89.12	89.1	Effective physician-patient communication and health outcomes: a review.	M A Stewart	CMAJ	1995	7728691	Yes
842	4527	2263.5	0.0	0.0	The interpretation of protein structures: estimation of static accessibility.	B Lee, F M Richards	J Mol Biol	1971	5551392	Yes
843	2263	2263.0	104.0	104.0	Structural Model Evaluation and Modification: An Interval Estimation Approach.	J H Steiger	Multivariate Behav Res	1990	26794479	Yes
844	4518	2259.0	121.52	60.8	Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up.	C W Elston, I O Ellis	Histopathology	1991	1757079	Yes
845	2259	2259.0	65.7	65.7	Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century.	M Leavitt	MedGenMed	2001	11549951	No
846	2259	2259.0	90.03	90.0	Missing data analysis: making it work in the real world.	John W Graham	Annu Rev Psychol	2009	18652544	No
847	4513	2256.5	116.33	58.2	A receptor-mediated pathway for cholesterol homeostasis.	M S Brown, J L Goldstein	Science	1986	3513311	No
848	2254	2254.0	49.43	49.4	Chemokines and leukocyte traffic.	M Baggiolini	Nature	1998	9560152	No
849	2249	2249.0	72.15	72.2	Social cognitive theory: an agentic perspective.	A Bandura	Annu Rev Psychol	2001	11148297	Yes
850	4497	2248.5	102.82	51.4	A simple and very efficient method for generating cDNA libraries.	U Gubler, B J Hoffman	Gene	1983	6198242	Yes
851	2244	2244.0	0.0	0.0	Separation of leukocytes from blood and bone marrow. Introduction.	A Böyum	Scand J Clin Lab Invest Suppl	1968	5707208	Yes
852	2241	2241.0	51.55	51.5	The inflammatory reflex.	Kevin J Tracey	Nature	2002	12490958	No
853	6715	2238.3	176.07	58.7	Cortical surface-based analysis. I. Segmentation and surface reconstruction.	A M Dale, B Fischl, M I Sereno	Neuroimage	1999	9931268	Yes
854	2238	2238.0	68.64	68.6	Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.	R A DeFronzo	Diabetes	1988	3289989	No
855	2238	2238.0	76.01	76.0	Epidemiology of viral hepatitis and hepatocellular carcinoma.	Hashem B El-Serag	Gastroenterology	2012	22537432	No
856	2236	2236.0	74.9	74.9	Working memory.	A Baddeley	Science	1992	1736359	No
857	4468	2234.0	88.35	44.2	Mechanisms of TGF-beta signaling from cell membrane to the nucleus.	Yigong Shi, Joan Massagué	Cell	2003	12809600	No
858	2234	2234.0	0.0	0.0	[Rapid physiological coagulation method in determination of fibrinogen].	A Clauss	Acta Haematol	1957	13434757	Yes
859	2233	2233.0	55.01	55.0	Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose.	J Kyhse-Andersen	J Biochem Biophys Methods	1984	6530509	Yes
860	2233	2233.0	53.0	53.0	Mechanisms and genes of cellular suicide.	H Steller	Science	1995	7878463	No
861	2231	2231.0	0.0	0.0	Mechanisms of action of transmitters and other substances on smooth muscle.	T B Bolton	Physiol Rev	1979	37533	No
862	2231	2231.0	61.85	61.9	Molecular diversity of glutamate receptors and implications for brain function.	S Nakanishi	Science	1992	1329206	No
863	2230	2230.0	42.45	42.5	Histone acetylation in chromatin structure and transcription.	M Grunstein	Nature	1997	9311776	No
864	2229	2229.0	48.06	48.1	NOX enzymes and the biology of reactive oxygen.	J David Lambeth	Nat Rev Immunol	2004	15039755	No
865	2227	2227.0	77.51	77.5	Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases.	B N Ames	Science	1983	6351251	No
866	4452	2226.0	120.1	60.0	Alzheimer's disease: the amyloid cascade hypothesis.	J A Hardy, G A Higgins	Science	1992	1566067	No
867	2226	2226.0	53.06	53.1	Protein kinase C and lipid signaling for sustained cellular responses.	Y Nishizuka	FASEB J	1995	7737456	No
868	4449	2224.5	99.07	49.5	Organization and expression of eucaryotic split genes coding for proteins.	R Breathnach, P Chambon	Annu Rev Biochem	1981	6791577	No
869	6670	2223.3	207.19	69.1	FastTree 2--approximately maximum-likelihood trees for large alignments.	Morgan N Price, Paramvir S Dehal, Adam P Arkin	PLoS One	2010	20224823	Yes
870	4446	2223.0	113.34	56.7	Acute-phase proteins and other systemic responses to inflammation.	C Gabay, I Kushner	N Engl J Med	1999	9971870	No
871	2221	2221.0	0.0	0.0	Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices.	T Higuchi	J Pharm Sci	1963	14088963	Yes
872	4441	2220.5	100.96	50.5	AKT/PKB signaling: navigating downstream.	Brendan D Manning, Lewis C Cantley	Cell	2007	17604717	No
873	2218	2218.0	50.62	50.6	Rab GTPases as coordinators of vesicle traffic.	Harald Stenmark	Nat Rev Mol Cell Biol	2009	19603039	No
874	4435	2217.5	123.99	62.0	Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging.	Michael D Fox, Marcus E Raichle	Nat Rev Neurosci	2007	17704812	No
875	4434	2217.0	163.19	81.6	The attention system of the human brain.	M I Posner, S E Petersen	Annu Rev Neurosci	1990	2183676	No
876	4434	2217.0	106.93	53.5	Protein misfolding, functional amyloid, and human disease.	Fabrizio Chiti, Christopher M Dobson	Annu Rev Biochem	2006	16756495	No
877	2216	2216.0	0.0	0.0	Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters.	F F Jöbsis	Science	1977	929199	Yes
878	2215	2215.0	56.75	56.8	Inferring the historical patterns of biological evolution.	M Pagel	Nature	1999	10553904	Yes
879	2213	2213.0	52.07	52.1	Specification of cerebral cortical areas.	P Rakic	Science	1988	3291116	No
880	4426	2213.0	129.28	64.6	Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9167458	Yes
881	2211	2211.0	48.87	48.9	The regulation of AP-1 activity by mitogen-activated protein kinases.	M Karin	J Biol Chem	1995	7622446	No
882	15473	2210.4	640.5	91.5	limma powers differential expression analyses for RNA-sequencing and microarray studies.	Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth	Nucleic Acids Res	2015	25605792	Yes
883	2210	2210.0	0.0	0.0	Intracellular aspects of the process of protein synthesis.	G Palade	Science	1975	1096303	No
884	4417	2208.5	95.05	47.5	Mass spectrometry-based proteomics.	Ruedi Aebersold, Matthias Mann	Nature	2003	12634793	No
885	4415	2207.5	0.0	0.0	A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.	J E TILL, E A McCULLOCH	Radiat Res	1961	13776896	Yes
886	4411	2205.5	127.87	63.9	The number of people with glaucoma worldwide in 2010 and 2020.	H A Quigley, A T Broman	Br J Ophthalmol	2006	16488940	Yes
887	2205	2205.0	83.38	83.4	Role of endothelium in responses of vascular smooth muscle.	R F Furchgott	Circ Res	1983	6313250	No
888	4409	2204.5	132.03	66.0	Missing data: our view of the state of the art.	Joseph L Schafer, John W Graham	Psychol Methods	2002	12090408	Yes
889	2202	2202.0	68.48	68.5	Prooxidant states and tumor promotion.	P A Cerutti	Science	1985	2981433	No
890	2202	2202.0	48.03	48.0	Nitric oxide and the immune response.	C Bogdan	Nat Immunol	2001	11577346	No
891	4403	2201.5	0.0	0.0	The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin.	J A Spudich, S Watt	J Biol Chem	1971	4254541	Yes
892	2201	2201.0	43.23	43.2	Mechanisms of type-I- and type-II-interferon-mediated signalling.	Leonidas C Platanias	Nat Rev Immunol	2005	15864272	No
893	2201	2201.0	87.49	87.5	KDIGO clinical practice guidelines for acute kidney injury.	Arif Khwaja	Nephron Clin Pract	2012	22890468	No
894	2199	2199.0	82.39	82.4	Specific impairments of planning.	T Shallice	Philos Trans R Soc Lond B Biol Sci	1982	6125971	Yes
895	2196	2196.0	0.0	0.0	Isolation by Distance.	S Wright	Genetics	1943	17247074	Yes
896	4390	2195.0	163.74	81.9	Self-rated health and mortality: a review of twenty-seven community studies.	E L Idler, Y Benyamini	J Health Soc Behav	1997	9097506	No
897	2195	2195.0	43.92	43.9	The molecular biology of memory storage: a dialogue between genes and synapses.	E R Kandel	Science	2001	11691980	No
898	4388	2194.0	99.57	49.8	The Bcl-2 protein family: arbiters of cell survival.	J M Adams, S Cory	Science	1998	9735050	No
899	2193	2193.0	54.94	54.9	Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens.	Jane Glazebrook	Annu Rev Phytopathol	2005	16078883	No
900	6579	2193.0	201.02	67.0	Arlequin (version 3.0): an integrated software package for population genetics data analysis.	Laurent Excoffier, Guillaume Laval, Stefan Schneider	Evol Bioinform Online	2007	19325852	Yes
901	19734	2192.7	662.82	73.6	STAR: ultrafast universal RNA-seq aligner.	Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R Gingeras	Bioinformatics	2013	23104886	Yes
902	4384	2192.0	107.71	53.9	Regulation of the mevalonate pathway.	J L Goldstein, M S Brown	Nature	1990	1967820	No
903	2192	2192.0	0.0	0.0	Removal of fatty acids from serum albumin by charcoal treatment.	R F Chen	J Biol Chem	1967	6016603	Yes
904	4383	2191.5	0.0	0.0	Judgment under Uncertainty: Heuristics and Biases.	A Tversky, D Kahneman	Science	1974	17835457	Yes
905	2187	2187.0	55.28	55.3	RGD and other recognition sequences for integrins.	E Ruoslahti	Annu Rev Cell Dev Biol	1996	8970741	No
906	4373	2186.5	95.79	47.9	Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.	F Sallusto, A Lanzavecchia	J Exp Med	1994	8145033	Yes
907	2186	2186.0	66.08	66.1	Diagnosis of Alzheimer's disease.	Z S Khachaturian	Arch Neurol	1985	2864910	Yes
908	4366	2183.0	126.62	63.3	Distributed hierarchical processing in the primate cerebral cortex.	D J Felleman, D C Van Essen	Cereb Cortex	1991	1822724	No
909	6548	2182.7	236.69	78.9	Effect of the damping function in dispersion corrected density functional theory.	Stefan Grimme, Stephan Ehrlich, Lars Goerigk	J Comput Chem	2011	21370243	Yes
910	2182	2182.0	70.83	70.8	Plant products as antimicrobial agents.	M M Cowan	Clin Microbiol Rev	1999	10515903	No
911	4363	2181.5	0.0	0.0	Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.	T V Bliss, T Lomo	J Physiol	1973	4727084	Yes
912	2181	2181.0	69.07	69.1	Human error: models and management.	J Reason	BMJ	2000	10720363	Yes
913	17446	2180.8	556.43	69.6	The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.	D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C Siebert	N Engl J Med	1993	8366922	Yes
914	2177	2177.0	63.95	64.0	Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES).	Gunther Eysenbach	J Med Internet Res	2004	15471760	No
915	2176	2176.0	68.82	68.8	Biodiesel from microalgae.	Yusuf Chisti	Biotechnol Adv	2007	17350212	No
916	2171	2171.0	48.54	48.5	Chemokines.	B J Rollins	Blood	1997	9242519	No
917	2170	2170.0	0.0	0.0	Presidential Address-1976. Social support as a moderator of life stress.	S Cobb	Psychosom Med	1976	981490	Yes
918	4338	2169.0	107.43	53.7	Nonparametric permutation tests for functional neuroimaging: a primer with examples.	Thomas E Nichols, Andrew P Holmes	Hum Brain Mapp	2002	11747097	Yes
919	2168	2168.0	79.14	79.1	Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals.	H W Steinbusch	Neuroscience	1981	7017455	Yes
920	2165	2165.0	58.58	58.6	The importance of selenium to human health.	M P Rayman	Lancet	2000	10963212	No
921	2163	2163.0	79.31	79.3	Doxil®--the first FDA-approved nano-drug: lessons learned.	Yechezkel Barenholz	J Control Release	2012	22484195	No
922	2156	2156.0	0.0	0.0	Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli.	G Bertani	J Bacteriol	1951	14888646	Yes
923	2155	2155.0	0.0	0.0	Sedimentation Studies Of The Size And Shape Of Dna.	F W Studier	J Mol Biol	1965	14290352	Yes
924	2154	2154.0	89.81	89.8	A systematic method for clinical description and classification of personality variants. A proposal.	C R Cloninger	Arch Gen Psychiatry	1987	3579504	Yes
925	2153	2153.0	0.0	0.0	The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations.	W W Cleland	Biochim Biophys Acta	1963	14021667	Yes
926	2152	2152.0	41.93	41.9	Protein modules and signalling networks.	T Pawson	Nature	1995	7531822	No
927	2152	2152.0	70.46	70.5	Eye movements in reading and information processing: 20 years of research.	K Rayner	Psychol Bull	1998	9849112	No
928	2146	2146.0	56.63	56.6	Working memory: looking back and looking forward.	Alan Baddeley	Nat Rev Neurosci	2003	14523382	No
929	4291	2145.5	118.64	59.3	A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.	Y Matsumura, H Maeda	Cancer Res	1986	2946403	Yes
930	4290	2145.0	0.0	0.0	The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase.	H P Misra, I Fridovich	J Biol Chem	1972	4623845	Yes
931	4290	2145.0	118.8	59.4	Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium.	Kresse, Hafner	Phys Rev B Condens Matter	1994	10010505	Yes
932	2144	2144.0	65.57	65.6	A two process model of sleep regulation.	A A Borbély	Hum Neurobiol	1982	7185792	Yes
933	8573	2143.2	190.04	47.5	Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.	A Krogh, B Larsson, G von Heijne, E L Sonnhammer	J Mol Biol	2001	11152613	Yes
934	2141	2141.0	72.25	72.2	Simplified calculation of body-surface area.	R D Mosteller	N Engl J Med	1987	3657876	Yes
935	2140	2140.0	70.66	70.7	Qualitative research: standards, challenges, and guidelines.	K Malterud	Lancet	2001	11513933	Yes
936	2139	2139.0	62.33	62.3	Hybrid porous solids: past, present, future.	Gérard Férey	Chem Soc Rev	2008	18197340	Yes
937	4274	2137.0	0.0	0.0	A Simplified Lead Citrate Stain For Use In Electron Microscopy.	J H Venable, R Coggeshall	J Cell Biol	1965	14287192	Yes
938	4271	2135.5	0.0	0.0	Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method.	R B Devereux, N Reichek	Circulation	1977	138494	Yes
939	4271	2135.5	107.29	53.6	Function and activation of NF-kappa B in the immune system.	P A Baeuerle, T Henkel	Annu Rev Immunol	1994	8011280	No
940	4271	2135.5	117.45	58.7	Application of phylogenetic networks in evolutionary studies.	Daniel H Huson, David Bryant	Mol Biol Evol	2006	16221896	Yes
941	6405	2135.0	0.0	0.0	Glucose clamp technique: a method for quantifying insulin secretion and resistance.	R A DeFronzo, J D Tobin, R Andres	Am J Physiol	1979	382871	Yes
942	2135	2135.0	57.08	57.1	The blood-brain barrier in health and chronic neurodegenerative disorders.	Berislav V Zlokovic	Neuron	2008	18215617	No
943	2135	2135.0	0.0	0.0	A new specific color reaction of hexuronic acids.	Z Dische	J Biol Chem	1947	20281638	Yes
944	2134	2134.0	49.25	49.2	Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity.	G Trinchieri	Annu Rev Immunol	1995	7612223	No
945	2134	2134.0	46.42	46.4	Complement. First of two parts.	M J Walport	N Engl J Med	2001	11287977	No
946	2134	2134.0	58.09	58.1	Pancreatic cancer.	Manuel Hidalgo	N Engl J Med	2010	20427809	No
947	4266	2133.0	101.39	50.7	Assembly of asparagine-linked oligosaccharides.	R Kornfeld, S Kornfeld	Annu Rev Biochem	1985	3896128	No
948	4262	2131.0	124.12	62.1	Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly.	J S Beckman, W H Koppenol	Am J Physiol	1996	8944624	No
949	2130	2130.0	96.35	96.3	Statistics corner: A guide to appropriate use of correlation coefficient in medical research.	M M Mukaka	Malawi Med J	2012	23638278	Yes
950	2128	2128.0	68.93	68.9	Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men.	W A Craig	Clin Infect Dis	1998	9455502	No
951	2128	2128.0	68.3	68.3	Spinal and supraspinal factors in human muscle fatigue.	S C Gandevia	Physiol Rev	2001	11581501	No
952	4253	2126.5	153.67	76.8	The biofilm matrix.	Hans-Curt Flemming, Jost Wingender	Nat Rev Microbiol	2010	20676145	No
953	2126	2126.0	59.13	59.1	Carbonic anhydrases: novel therapeutic applications for inhibitors and activators.	Claudiu T Supuran	Nat Rev Drug Discov	2008	18167490	No
954	2125	2125.0	53.04	53.0	Breast cancer and hormone-replacement therapy in the Million Women Study.	Valerie Beral	Lancet	2003	12927427	Yes
955	2124	2124.0	0.0	0.0	The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers.	D E Atkinson	Biochemistry	1968	4972613	Yes
956	4248	2124.0	126.07	63.0	Nonparametric statistical testing of EEG- and MEG-data.	Eric Maris, Robert Oostenveld	J Neurosci Methods	2007	17517438	Yes
957	2119	2119.0	50.3	50.3	Patterns of amino acids near signal-sequence cleavage sites.	G von Heijne	Eur J Biochem	1983	6852022	Yes
958	2116	2116.0	70.49	70.5	A classification of glycosyl hydrolases based on amino acid sequence similarities.	B Henrissat	Biochem J	1991	1747104	Yes
959	2115	2115.0	59.18	59.2	Superoxide radical and superoxide dismutases.	I Fridovich	Annu Rev Biochem	1995	7574505	No
960	2115	2115.0	0.0	0.0	Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids.	D Aminoff	Biochem J	1961	13860975	Yes
961	2114	2114.0	54.5	54.5	A theory of cortical responses.	Karl Friston	Philos Trans R Soc Lond B Biol Sci	2005	15937014	No
962	6338	2112.7	184.52	61.5	Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.	C E Murry, R B Jennings, K A Reimer	Circulation	1986	3769170	Yes
963	2112	2112.0	85.64	85.6	Role of Streptococcus mutans in human dental decay.	W J Loesche	Microbiol Rev	1986	3540569	No
964	2110	2110.0	44.78	44.8	Mammalian G1 cyclins.	C J Sherr	Cell	1993	8513492	No
965	4215	2107.5	121.33	60.7	Angiogenic factors.	J Folkman, M Klagsbrun	Science	1987	2432664	No
966	6322	2107.3	145.9	48.6	MOLMOL: a program for display and analysis of macromolecular structures.	R Koradi, M Billeter, K Wüthrich	J Mol Graph	1996	8744573	Yes
967	6315	2105.0	0.0	0.0	Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.	B N Ames, J Mccann, E Yamasaki	Mutat Res	1975	768755	Yes
968	2104	2104.0	56.27	56.3	Epidemiology of insomnia: what we know and what we still need to learn.	Maurice M Ohayon	Sleep Med Rev	2002	12531146	Yes
969	2104	2104.0	0.0	0.0	Analysis of tissue and arterial blood temperatures in the resting human forearm.	H H Pennes	J Appl Physiol	1948	18887578	Yes
970	2103	2103.0	51.51	51.5	Animal mitochondrial genomes.	J L Boore	Nucleic Acids Res	1999	10101183	No
971	4206	2103.0	0.0	0.0	Loss of recent memory after bilateral hippocampal lesions.	W B Scoville, B Milner	J Neurol Neurosurg Psychiatry	1957	13406589	Yes
972	2101	2101.0	64.44	64.4	Fetal origins of coronary heart disease.	D J Barker	BMJ	1995	7613432	No
973	4202	2101.0	142.28	71.1	Microenvironmental regulation of tumor progression and metastasis.	Daniela F Quail, Johanna A Joyce	Nat Med	2013	24202395	No
974	2100	2100.0	40.49	40.5	Shelterin: the protein complex that shapes and safeguards human telomeres.	Titia de Lange	Genes Dev	2005	16166375	No
975	2099	2099.0	0.0	0.0	Chemiosmotic coupling in oxidative and photosynthetic phosphorylation.	P Mitchell	Biol Rev Camb Philos Soc	1966	5329743	No
976	2099	2099.0	62.56	62.6	Hazards of heavy metal contamination.	Lars Järup	Br Med Bull	2003	14757716	No
977	4196	2098.0	108.4	54.2	Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.	M Matsuda, R A DeFronzo	Diabetes Care	1999	10480510	Yes
978	4193	2096.5	106.74	53.4	Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results.	E Lander, L Kruglyak	Nat Genet	1995	7581446	Yes
979	2094	2094.0	63.72	63.7	The unbiased estimation of number and sizes of arbitrary particles using the disector.	D C Sterio	J Microsc	1984	6737468	Yes
980	18846	2094.0	972.38	108.0	Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.	Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray	Int J Cancer	2015	25220842	Yes
981	2091	2091.0	54.06	54.1	Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details.	R D Pascual-Marqui	Methods Find Exp Clin Pharmacol	2002	12575463	No
982	2090	2090.0	55.19	55.2	The molecular pathology of Alzheimer's disease.	D J Selkoe	Neuron	1991	1673054	No
983	4180	2090.0	80.82	40.4	The fundamental role of epigenetic events in cancer.	Peter A Jones, Stephen B Baylin	Nat Rev Genet	2002	12042769	No
984	2089	2089.0	0.0	0.0	The plasma lecithins:cholesterol acyltransferase reaction.	J A Glomset	J Lipid Res	1968	4868699	No
985	2088	2088.0	64.59	64.6	The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions.	B L Fredrickson	Am Psychol	2001	11315248	Yes
986	4175	2087.5	95.75	47.9	Brown adipose tissue: function and physiological significance.	Barbara Cannon, Jan Nedergaard	Physiol Rev	2004	14715917	No
987	2086	2086.0	83.47	83.5	Approximate entropy as a measure of system complexity.	S M Pincus	Proc Natl Acad Sci U S A	1991	11607165	Yes
988	2085	2085.0	42.7	42.7	Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self.	Shimon Sakaguchi	Nat Immunol	2005	15785760	No
989	2084	2084.0	0.0	0.0	Method For Assay Of Intestinal Disaccharidases.	A Dahlqvist	Anal Biochem	1964	14106916	Yes
990	2080	2080.0	54.0	54.0	Descending control of pain.	Mark J Millan	Prog Neurobiol	2002	12034378	No
991	2080	2080.0	58.27	58.3	Intestinal mucosal barrier function in health and disease.	Jerrold R Turner	Nat Rev Immunol	2009	19855405	No
992	2079	2079.0	48.23	48.2	Pathways towards and away from Alzheimer's disease.	Mark P Mattson	Nature	2004	15295589	No
993	2079	2079.0	54.44	54.4	Network pharmacology: the next paradigm in drug discovery.	Andrew L Hopkins	Nat Chem Biol	2008	18936753	No
994	4150	2075.0	102.23	51.1	Hepatocellular carcinoma: epidemiology and molecular carcinogenesis.	Hashem B El-Serag, K Lenhard Rudolph	Gastroenterology	2007	17570226	No
995	4147	2073.5	0.0	0.0	Variations in pattern of pubertal changes in girls.	W A Marshall, J M Tanner	Arch Dis Child	1969	5785179	Yes
996	2072	2072.0	86.3	86.3	The validity and practicality of sun-reactive skin types I through VI.	T B Fitzpatrick	Arch Dermatol	1988	3377516	Yes
997	2072	2072.0	39.75	39.8	NK cell recognition.	Lewis L Lanier	Annu Rev Immunol	2005	15771571	No
998	2071	2071.0	83.09	83.1	A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992.	E L Bradley	Arch Surg	1993	8489394	No
999	2069	2069.0	68.64	68.6	Keratoconus.	Y S Rabinowitz	Surv Ophthalmol	1998	9493273	No
1000	8275	2068.8	205.42	51.4	Matrix elasticity directs stem cell lineage specification.	Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E Discher	Cell	2006	16923388	Yes
1001	2068	2068.0	46.91	46.9	A clearer vision for in vivo imaging.	R Weissleder	Nat Biotechnol	2001	11283581	No
1002	2068	2068.0	0.0	0.0	Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane.	J C Skou	Physiol Rev	1965	14337569	No
1003	4135	2067.5	87.27	43.6	A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.	G Shaw, R Kamen	Cell	1986	3488815	Yes
1004	2067	2067.0	106.58	106.6	Conservation of resources. A new attempt at conceptualizing stress.	S E Hobfoll	Am Psychol	1989	2648906	No
1005	2067	2067.0	0.0	0.0	Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants.	J W Littlefield	Science	1964	14168277	Yes
1006	2065	2065.0	61.71	61.7	TGFβ signalling in context.	Joan Massagué	Nat Rev Mol Cell Biol	2012	22992590	No
1007	6194	2064.7	0.0	0.0	Immunochemical quantitation of antigens by single radial immunodiffusion.	G Mancini, A O Carbonara, J F Heremans	Immunochemistry	1965	4956917	Yes
1008	2063	2063.0	57.09	57.1	The episodic buffer: a new component of working memory?	Baddeley	Trends Cogn Sci	2000	11058819	Yes
1009	2062	2062.0	42.86	42.9	Role of angiogenesis in tumor growth and metastasis.	Judah Folkman	Semin Oncol	2002	12516034	No
1010	6186	2062.0	119.07	39.7	Control of regulatory T cell development by the transcription factor Foxp3.	Shohei Hori, Takashi Nomura, Shimon Sakaguchi	Science	2003	12522256	Yes
1011	2061	2061.0	50.52	50.5	Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences.	Edward V Loftus	Gastroenterology	2004	15168363	Yes
1012	2059	2059.0	42.79	42.8	G1 events and regulation of cell proliferation.	A B Pardee	Science	1989	2683075	No
1013	2057	2057.0	52.34	52.3	An index to quantify an individual's scientific research output.	J E Hirsch	Proc Natl Acad Sci U S A	2005	16275915	Yes
1014	4112	2056.0	131.8	65.9	A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.	Gary J Bennett, Y-K Xie	Pain	1988	2837713	Yes
1015	4112	2056.0	102.04	51.0	Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.	Michael T Lin, M Flint Beal	Nature	2006	17051205	No
1016	4109	2054.5	0.0	0.0	Plaque formation and isolation of pure lines with poliomyelitis viruses.	R Dulbecco, M Vogt	J Exp Med	1954	13130792	Yes
1017	2054	2054.0	59.48	59.5	ATP-regulated K+ channels in cardiac muscle.	A Noma	Nature	1983	6310409	Yes
1018	4106	2053.0	107.68	53.8	The heat-shock proteins.	S Lindquist, E A Craig	Annu Rev Genet	1988	2853609	No
1019	2048	2048.0	53.5	53.5	The heme oxygenase system: a regulator of second messenger gases.	M D Maines	Annu Rev Pharmacol Toxicol	1997	9131263	No
1020	8190	2047.5	404.32	101.1	IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies.	Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang Minh	Mol Biol Evol	2015	25371430	Yes
1021	2045	2045.0	48.27	48.3	Interleukin-2: inception, impact, and implications.	K A Smith	Science	1988	3131876	No
1022	12268	2044.7	276.13	46.0	NMRPipe: a multidimensional spectral processing system based on UNIX pipes.	F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A Bax	J Biomol NMR	1995	8520220	Yes
1023	2044	2044.0	55.98	56.0	MYC on the path to cancer.	Chi V Dang	Cell	2012	22464321	No
1024	2041	2041.0	89.13	89.1	The Children's Depression, Inventory (CDI).	M Kovacs	Psychopharmacol Bull	1985	4089116	Yes
1025	4081	2040.5	81.39	40.7	Network biology: understanding the cell's functional organization.	Albert-László Barabási, Zoltán N Oltvai	Nat Rev Genet	2004	14735121	No
1026	6120	2040.0	187.37	62.5	The brain's default network: anatomy, function, and relevance to disease.	Randy L Buckner, Jessica R Andrews-Hanna, Daniel L Schacter	Ann N Y Acad Sci	2008	18400922	No
1027	4079	2039.5	82.01	41.0	Mammalian MAP kinase signalling cascades.	L Chang, M Karin	Nature	2001	11242034	No
1028	4072	2036.0	0.0	0.0	Genetic regulatory mechanisms in the synthesis of proteins.	F Jacob, J Monod	J Mol Biol	1961	13718526	Yes
1029	4070	2035.0	81.1	40.5	Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.	M Gossen, H Bujard	Proc Natl Acad Sci U S A	1992	1319065	Yes
1030	4065	2032.5	99.3	49.6	Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction.	P Liang, A B Pardee	Science	1992	1354393	Yes
1031	4061	2030.5	110.65	55.3	New perspectives in cell adhesion: RGD and integrins.	E Ruoslahti, M D Pierschbacher	Science	1987	2821619	No
1032	4059	2029.5	99.23	49.6	Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.	G G Glenner, C W Wong	Biochem Biophys Res Commun	1984	6375662	Yes
1033	2029	2029.0	87.99	88.0	The biology and function of fibroblasts in cancer.	Raghu Kalluri	Nat Rev Cancer	2016	27550820	No
1034	2028	2028.0	60.08	60.1	Social determinants of health inequalities.	Michael Marmot	Lancet	2005	15781105	Yes
1035	2026	2026.0	0.0	0.0	Purinergic nerves.	G Burnstock	Pharmacol Rev	1972	4404211	No
1036	2026	2026.0	47.78	47.8	Calcium signaling.	D E Clapham	Cell	1995	7834745	No
1037	2025	2025.0	51.12	51.1	Determination and analysis of urea and guanidine hydrochloride denaturation curves.	C N Pace	Methods Enzymol	1986	3773761	Yes
1038	2025	2025.0	52.06	52.1	Accurate description of van der Waals complexes by density functional theory including empirical corrections.	Stefan Grimme	J Comput Chem	2004	15224390	Yes
1039	2024	2024.0	44.77	44.8	Structural design and molecular evolution of a cytokine receptor superfamily.	J F Bazan	Proc Natl Acad Sci U S A	1990	2169613	Yes
1040	2023	2023.0	0.0	0.0	Antigen-antibody reactions in gels.	O Ouchterlony	Acta Pathol Microbiol Scand	1949	18143039	Yes
1041	2022	2022.0	45.15	45.1	Defensins: antimicrobial peptides of innate immunity.	Tomas Ganz	Nat Rev Immunol	2003	12949495	No
1042	2022	2022.0	61.99	62.0	PsychoPy--Psychophysics software in Python.	Jonathan W Peirce	J Neurosci Methods	2007	17254636	Yes
1043	2022	2022.0	64.82	64.8	Ethical authorship and publishing.	Andrew J S Coats	Int J Cardiol	2009	19046787	No
1044	2021	2021.0	0.0	0.0	Analysis of bacteriophage T7 early RNAs and proteins on slab gels.	F W Studier	J Mol Biol	1973	4760132	Yes
1045	2020	2020.0	73.16	73.2	International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results.	C Herrmann	J Psychosom Res	1997	9055211	No
1046	4039	2019.5	177.4	88.7	The Health Belief Model: a decade later.	N K Janz, M H Becker	Health Educ Q	1984	6392204	No
1047	2015	2015.0	55.57	55.6	Biofilms: microbial life on surfaces.	Rodney M Donlan	Emerg Infect Dis	2002	12194761	No
1048	2015	2015.0	52.49	52.5	The extracellular matrix: not just pretty fibrils.	Richard O Hynes	Science	2009	19965464	No
1049	2014	2014.0	0.0	0.0	Comparison of the predicted and observed secondary structure of T4 phage lysozyme.	B W Matthews	Biochim Biophys Acta	1975	1180967	Yes
1050	2014	2014.0	43.81	43.8	Theta oscillations in the hippocampus.	György Buzsáki	Neuron	2002	11832222	No
1051	2014	2014.0	76.4	76.4	Gctf: Real-time CTF determination and correction.	Kai Zhang	J Struct Biol	2016	26592709	Yes
1052	2013	2013.0	100.24	100.2	Deep learning in neural networks: an overview.	Jürgen Schmidhuber	Neural Netw	2015	25462637	No
1053	8049	2012.2	194.43	48.6	Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.	C A Lipinski, F Lombardo, B W Dominy, P J Feeney	Adv Drug Deliv Rev	2001	11259830	No
1054	2012	2012.0	72.0	72.0	Determination of glutathione and glutathione disulfide in biological samples.	M E Anderson	Methods Enzymol	1985	4088074	Yes
1055	2011	2011.0	53.36	53.4	The physiology of glucagon-like peptide 1.	Jens Juul Holst	Physiol Rev	2007	17928588	No
1056	4021	2010.5	80.59	40.3	Smad-dependent and Smad-independent pathways in TGF-beta family signalling.	Rik Derynck, Ying E Zhang	Nature	2003	14534577	No
1057	4018	2009.0	182.07	91.0	Stages and processes of self-change of smoking: toward an integrative model of change.	J O Prochaska, C C DiClemente	J Consult Clin Psychol	1983	6863699	Yes
1058	2005	2005.0	56.59	56.6	Estimating causal effects from large data sets using propensity scores.	D B Rubin	Ann Intern Med	1997	9382394	No
1059	2004	2004.0	41.76	41.8	Molecular bases for circadian clocks.	J C Dunlap	Cell	1999	9988221	No
1060	2004	2004.0	41.98	42.0	XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density.	D E McRee	J Struct Biol	1999	10222271	Yes
1061	2003	2003.0	58.49	58.5	Protein oxidation and aging.	E R Stadtman	Science	1992	1355616	No
1062	2001	2001.0	44.26	44.3	Biology of natural killer cells.	G Trinchieri	Adv Immunol	1989	2683611	No
1063	11991	1998.5	390.65	65.1	Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.	Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell Parkin	Int J Cancer	2010	21351269	Yes
1064	7981	1995.2	165.38	41.3	WebLogo: a sequence logo generator.	Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E Brenner	Genome Res	2004	15173120	Yes
1065	3988	1994.0	79.9	40.0	Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals.	Rudolf Jaenisch, Adrian Bird	Nat Genet	2003	12610534	No
1066	3985	1992.5	100.66	50.3	A scaling normalization method for differential expression analysis of RNA-seq data.	Mark D Robinson, Alicia Oshlack	Genome Biol	2010	20196867	Yes
1067	5977	1992.3	198.82	66.3	Parallel organization of functionally segregated circuits linking basal ganglia and cortex.	G E Alexander, M R DeLong, P L Strick	Annu Rev Neurosci	1986	3085570	No
1068	1992	1992.0	49.29	49.3	Dopamine, learning and motivation.	Roy A Wise	Nat Rev Neurosci	2004	15152198	No
1069	1991	1991.0	0.0	0.0	The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis.	U E Loening	Biochem J	1967	5339944	Yes
1070	1991	1991.0	41.11	41.1	Metastasis to bone: causes, consequences and therapeutic opportunities.	Gregory R Mundy	Nat Rev Cancer	2002	12154351	No
1071	3981	1990.5	94.07	47.0	Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.	B A Reynolds, S Weiss	Science	1992	1553558	Yes
1072	5966	1988.7	188.84	62.9	Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire.	R L Spitzer, K Kroenke, J B Williams	JAMA	1999	10568646	Yes
1073	1988	1988.0	35.3	35.3	ATM and related protein kinases: safeguarding genome integrity.	Yosef Shiloh	Nat Rev Cancer	2003	12612651	No
1074	1987	1987.0	53.71	53.7	Endoplasmic reticulum stress and the inflammatory basis of metabolic disease.	Gökhan S Hotamisligil	Cell	2010	20303879	No
1075	1986	1986.0	111.67	111.7	Determination and quantification of content validity.	M R Lynn	Nurs Res	1986	3640358	Yes
1076	5951	1983.7	123.78	41.3	EMBOSS: the European Molecular Biology Open Software Suite.	P Rice, I Longden, A Bleasby	Trends Genet	2000	10827456	Yes
1077	1980	1980.0	39.31	39.3	CpG motifs in bacterial DNA and their immune effects.	Arthur M Krieg	Annu Rev Immunol	2002	11861616	No
1078	1979	1979.0	40.93	40.9	Mechanisms of intracellular protein transport.	J E Rothman	Nature	1994	7969419	No
1079	5937	1979.0	142.77	47.6	APE: Analyses of Phylogenetics and Evolution in R language.	Emmanuel Paradis, Julien Claude, Korbinian Strimmer	Bioinformatics	2004	14734327	Yes
1080	3955	1977.5	98.7	49.4	Cutaneous wound healing.	A J Singer, R A Clark	N Engl J Med	1999	10471461	No
1081	1977	1977.0	53.25	53.2	Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis.	J Folkman	N Engl J Med	1995	7491141	No
1082	5931	1977.0	226.11	75.4	Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA.	G Muyzer, E C de Waal, A G Uitterlinden	Appl Environ Microbiol	1993	7683183	Yes
1083	5930	1976.7	149.69	49.9	GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants.	R A Jefferson, T A Kavanagh, M W Bevan	EMBO J	1987	3327686	Yes
1084	1973	1973.0	50.32	50.3	Mechanisms of hepatic fibrogenesis.	Scott L Friedman	Gastroenterology	2008	18471545	No
1085	1967	1967.0	50.16	50.2	P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation.	Berk Hess	J Chem Theory Comput	2008	26619985	Yes
1086	3933	1966.5	96.37	48.2	Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.	M Nei, T Gojobori	Mol Biol Evol	1986	3444411	Yes
1087	5898	1966.0	166.04	55.3	Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors.	F E Harrell, K L Lee, D B Mark	Stat Med	1996	8668867	No
1088	1965	1965.0	39.06	39.1	Signalling pathways of the TNF superfamily: a double-edged sword.	Bharat B Aggarwal	Nat Rev Immunol	2003	12949498	No
1089	3930	1965.0	105.6	52.8	ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT.	B Ravel, M Newville	J Synchrotron Radiat	2005	15968136	Yes
1090	7860	1965.0	299.18	74.8	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	J Clin Epidemiol	2009	19631508	No
1091	3929	1964.5	84.99	42.5	Lessons from hereditary colorectal cancer.	K W Kinzler, B Vogelstein	Cell	1996	8861899	No
1092	3928	1964.0	85.69	42.8	The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.	A J Ridley, A Hall	Cell	1992	1643657	Yes
1093	1964	1964.0	54.37	54.4	The biology of interleukin-6.	T Kishimoto	Blood	1989	2473791	No
1094	7848	1962.0	259.46	64.9	Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.	A J Hughes, S E Daniel, L Kilford, A J Lees	J Neurol Neurosurg Psychiatry	1992	1564476	Yes
1095	3923	1961.5	96.86	48.4	Measuring the thickness of the human cerebral cortex from magnetic resonance images.	B Fischl, A M Dale	Proc Natl Acad Sci U S A	2000	10984517	Yes
1096	3921	1960.5	107.01	53.5	The inflammasomes.	Kate Schroder, Jurg Tschopp	Cell	2010	20303873	No
1097	1960	1960.0	105.48	105.5	The assessment of clinical skills/competence/performance.	G E Miller	Acad Med	1990	2400509	Yes
1098	5880	1960.0	121.47	40.5	Rapid and efficient site-specific mutagenesis without phenotypic selection.	T A Kunkel, J D Roberts, R A Zakour	Methods Enzymol	1987	3323813	Yes
1099	1960	1960.0	57.38	57.4	Infrared spectroscopy of proteins.	Andreas Barth	Biochim Biophys Acta	2007	17692815	No
1100	3919	1959.5	78.38	39.2	The Wnt signaling pathway in development and disease.	Catriona Y Logan, Roel Nusse	Annu Rev Cell Dev Biol	2004	15473860	No
1101	1959	1959.0	82.14	82.1	A rating scale for drug-induced akathisia.	T R Barnes	Br J Psychiatry	1989	2574607	Yes
1102	1959	1959.0	70.81	70.8	Large-scale brain networks and psychopathology: a unifying triple network model.	Vinod Menon	Trends Cogn Sci	2011	21908230	No
1103	1958	1958.0	36.06	36.1	In situ hybridization: an improved whole-mount method for Xenopus embryos.	R M Harland	Methods Cell Biol	1991	1811161	Yes
1104	1958	1958.0	49.82	49.8	Using circular dichroism spectra to estimate protein secondary structure.	Norma J Greenfield	Nat Protoc	2006	17406547	Yes
1105	3911	1955.5	108.2	54.1	Insulin-like growth factors and their binding proteins: biological actions.	J I Jones, D R Clemmons	Endocr Rev	1995	7758431	No
1106	3910	1955.0	0.0	0.0	Polymyositis and dermatomyositis (first of two parts).	A Bohan, J B Peter	N Engl J Med	1975	1090839	No
1107	1954	1954.0	0.0	0.0	The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera.	S V Boyden	J Exp Med	1951	14803635	Yes
1108	1953	1953.0	48.66	48.7	Drug-like properties and the causes of poor solubility and poor permeability.	C A Lipinski	J Pharmacol Toxicol Methods	2000	11274893	No
1109	1952	1952.0	0.0	0.0	Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?	J V Neel	Am J Hum Genet	1962	13937884	Yes
1110	1951	1951.0	0.0	0.0	Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle.	A Fleckenstein	Annu Rev Pharmacol Toxicol	1977	326161	No
1111	1949	1949.0	57.62	57.6	Intracellular calcium homeostasis.	E Carafoli	Annu Rev Biochem	1987	3304139	No
1112	3898	1949.0	0.0	0.0	Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy.	I W McLean, P K Nakane	J Histochem Cytochem	1974	4374474	Yes
1113	1949	1949.0	49.93	49.9	Flow-mediated endothelial mechanotransduction.	P F Davies	Physiol Rev	1995	7624393	No
1114	5838	1946.0	188.27	62.8	Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders.	C Lord, M Rutter, A Le Couteur	J Autism Dev Disord	1994	7814313	Yes
1115	1945	1945.0	0.0	0.0	Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate.	J P Chamberlain	Anal Biochem	1979	543547	Yes
1116	1944	1944.0	46.95	47.0	Follicular helper CD4 T cells (TFH).	Shane Crotty	Annu Rev Immunol	2011	21314428	No
1117	1944	1944.0	59.72	59.7	Hypoxia-inducible factors in physiology and medicine.	Gregg L Semenza	Cell	2012	22304911	No
1118	3886	1943.0	97.67	48.8	Leptin and the regulation of body weight in mammals.	J M Friedman, J L Halaas	Nature	1998	9796811	No
1119	3885	1942.5	0.0	0.0	Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid.	A C Chang, S N Cohen	J Bacteriol	1978	149110	Yes
1120	1942	1942.0	0.0	0.0	Crystalline Soybean Trypsin Inhibitor : Ii. General Properties.	M Kunitz	J Gen Physiol	1947	19873496	Yes
1121	3883	1941.5	96.82	48.4	Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.	P J Barnes, M Karin	N Engl J Med	1997	9091804	No
1122	1940	1940.0	34.99	35.0	Signaling--2000 and beyond.	T Hunter	Cell	2000	10647936	No
1123	1940	1940.0	46.66	46.7	DAMPs, PAMPs and alarmins: all we need to know about danger.	Marco E Bianchi	J Leukoc Biol	2007	17032697	No
1124	1939	1939.0	141.65	141.7	Hepatocellular Carcinoma.	Augusto Villanueva	N Engl J Med	2019	30970190	No
1125	1935	1935.0	64.36	64.4	Intermediate filaments as mechanical integrators of cellular space.	E Lazarides	Nature	1980	7188712	Yes
1126	1935	1935.0	37.97	38.0	Antiviral actions of interferons.	C E Samuel	Clin Microbiol Rev	2001	11585785	No
1127	1934	1934.0	61.7	61.7	Health consequences of intimate partner violence.	Jacquelyn C Campbell	Lancet	2002	11965295	No
1128	3867	1933.5	89.68	44.8	Base-calling of automated sequencer traces using phred. II. Error probabilities.	B Ewing, P Green	Genome Res	1998	9521922	Yes
1129	1933	1933.0	0.0	0.0	A modified card sorting test sensitive to frontal lobe defects.	H E Nelson	Cortex	1976	1009768	Yes
1130	1933	1933.0	93.27	93.3	Performance-oriented assessment of mobility problems in elderly patients.	M E Tinetti	J Am Geriatr Soc	1986	3944402	Yes
1131	3863	1931.5	89.46	44.7	The acute respiratory distress syndrome.	L B Ware, M A Matthay	N Engl J Med	2000	10793167	No
1132	1931	1931.0	64.6	64.6	The use of a plus-maze to measure anxiety in the mouse.	R G Lister	Psychopharmacology (Berl)	1987	3110839	Yes
1133	1931	1931.0	45.78	45.8	Metabolomics--the link between genotypes and phenotypes.	Oliver Fiehn	Plant Mol Biol	2002	11860207	No
1134	1930	1930.0	40.52	40.5	A cell culture model for T lymphocyte clonal anergy.	R H Schwartz	Science	1990	2113314	Yes
1135	1929	1929.0	0.0	0.0	Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma.	A Breslow	Ann Surg	1970	5477666	Yes
1136	1927	1927.0	38.64	38.6	DNA topoisomerases: structure, function, and mechanism.	J J Champoux	Annu Rev Biochem	2001	11395412	No
1137	1927	1927.0	0.0	0.0	Influences of glucose loading and of injected insulin on hepatic glucose output.	R Steele	Ann N Y Acad Sci	1959	13833973	Yes
1138	3854	1927.0	0.0	0.0	A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase.	R F Beers, I W Sizer	J Biol Chem	1952	14938361	Yes
1139	1926	1926.0	55.48	55.5	Excitotoxic cell death.	D W Choi	J Neurobiol	1992	1361523	No
1140	1925	1925.0	42.64	42.6	The distribution of secondary growths in cancer of the breast. 1889.	S Paget	Cancer Metastasis Rev	1989	2673568	No
1141	1925	1925.0	48.33	48.3	Negative refraction makes a perfect lens	Pendry	Phys Rev Lett	2000	11041972	Yes
1142	1925	1925.0	0.0	0.0	On estimating the relation between blood group and disease.	B Woolf	Ann Hum Genet	1955	14388528	Yes
1143	1925	1925.0	41.23	41.2	TRP channels as cellular sensors.	David E Clapham	Nature	2003	14654832	No
1144	1924	1924.0	43.29	43.3	Signal sequences. The limits of variation.	G von Heijne	J Mol Biol	1985	4032478	Yes
1145	1924	1924.0	47.76	47.8	Interfaces and the driving force of hydrophobic assembly.	David Chandler	Nature	2005	16193038	No
1146	3846	1923.0	166.63	83.3	The MOS social support survey.	C D Sherbourne, A L Stewart	Soc Sci Med	1991	2035047	Yes
1147	3846	1923.0	103.74	51.9	Inositol phosphates and cell signalling.	M J Berridge, R F Irvine	Nature	1989	2550825	No
1148	1921	1921.0	50.7	50.7	DNA topoisomerase poisons as antitumor drugs.	L F Liu	Annu Rev Biochem	1989	2549853	No
1149	7681	1920.2	290.75	72.7	The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire.	T F Heatherton, L T Kozlowski, R C Frecker, K O Fagerström	Br J Addict	1991	1932883	Yes
1150	3835	1917.5	109.19	54.6	Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration.	B J Marshall, J R Warren	Lancet	1984	6145023	Yes
1151	3832	1916.0	116.96	58.5	Wnt/β-catenin signaling and disease.	Hans Clevers, Roel Nusse	Cell	2012	22682243	No
1152	1915	1915.0	76.08	76.1	Perception of risk.	P Slovic	Science	1987	3563507	Yes
1153	3829	1914.5	136.13	68.1	Shifting the genomic gold standard for the prokaryotic species definition.	Michael Richter, Ramon Rosselló-Móra	Proc Natl Acad Sci U S A	2009	19855009	Yes
1154	1914	1914.0	57.3	57.3	Calbindin D-28k and parvalbumin in the rat nervous system.	M R Celio	Neuroscience	1990	2199841	Yes
1155	1914	1914.0	47.01	47.0	DNA topoisomerases.	J C Wang	Annu Rev Biochem	1985	2992360	No
1156	1913	1913.0	47.43	47.4	Lead- and drug-like compounds: the rule-of-five revolution.	Christopher A Lipinski	Drug Discov Today Technol	2004	24981612	Yes
1157	3825	1912.5	0.0	0.0	Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells.	J G Rheinwald, H Green	Cell	1975	1052771	Yes
1158	1912	1912.0	106.15	106.2	The antibiotic resistance crisis: part 1: causes and threats.	C Lee Ventola	P T	2015	25859123	Yes
1159	3823	1911.5	0.0	0.0	Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol.	W R Morrison, L M Smith	J Lipid Res	1964	14221106	Yes
1160	1907	1907.0	60.85	60.9	Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges.	Leonardo Pantoni	Lancet Neurol	2010	20610345	No
1161	1905	1905.0	37.69	37.7	Systems biology: a brief overview.	Hiroaki Kitano	Science	2002	11872829	No
1162	1904	1904.0	82.61	82.6	Brain dopamine receptors.	P Seeman	Pharmacol Rev	1980	6117090	No
1163	1904	1904.0	40.8	40.8	The immunopathogenesis of sepsis.	Jonathan Cohen	Nature	2002	12490963	No
1164	3808	1904.0	0.0	0.0	Acetylornithinase of Escherichia coli: partial purification and some properties.	H J Vogel, D M Bonner	J Biol Chem	1956	13278318	Yes
1165	7612	1903.0	189.48	47.4	p53 mutations in human cancers.	M Hollstein, D Sidransky, B Vogelstein, C C Harris	Science	1991	1905840	No
1166	1903	1903.0	39.72	39.7	Thrombin signalling and protease-activated receptors.	S R Coughlin	Nature	2000	11001069	No
1167	1903	1903.0	39.05	39.0	The expanding role of mitochondria in apoptosis.	X Wang	Genes Dev	2001	11711427	No
1168	3802	1901.0	166.67	83.3	The Brief Symptom Inventory: an introductory report.	L R Derogatis, N Melisaratos	Psychol Med	1983	6622612	Yes
1169	3801	1900.5	123.17	61.6	Oxygen toxicity, oxygen radicals, transition metals and disease.	B Halliwell, J M Gutteridge	Biochem J	1984	6326753	No
1170	1900	1900.0	0.0	0.0	In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain.	T R Chen	Exp Cell Res	1977	65285	Yes
1171	1900	1900.0	0.0	0.0	The oxidation of ribonuclease with performic acid.	C H Hirs	J Biol Chem	1956	13319283	Yes
1172	5695	1898.3	186.69	62.2	AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet.	P G Reeves, F H Nielsen, G C Fahey	J Nutr	1993	8229312	No
1173	1898	1898.0	54.63	54.6	Japanese Classification of Gastric Carcinoma - 2nd English Edition -	Japanese Gastric Cancer Association	Gastric Cancer	1998	11957040	Yes
1174	1896	1896.0	40.78	40.8	Developmental regulation of the growth plate.	Henry M Kronenberg	Nature	2003	12748651	No
1175	5688	1896.0	156.17	52.1	Regularization Paths for Generalized Linear Models via Coordinate Descent.	Jerome Friedman, Trevor Hastie, Rob Tibshirani	J Stat Softw	2010	20808728	Yes
1176	1893	1893.0	46.4	46.4	Thioredoxin.	A Holmgren	Annu Rev Biochem	1985	3896121	No
1177	3786	1893.0	94.94	47.5	The endophenotype concept in psychiatry: etymology and strategic intentions.	Irving I Gottesman, Todd D Gould	Am J Psychiatry	2003	12668349	No
1178	5678	1892.7	0.0	0.0	Research diagnostic criteria: rationale and reliability.	R L Spitzer, J Endicott, E Robins	Arch Gen Psychiatry	1978	655775	Yes
1179	13246	1892.3	296.29	42.3	Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes.	Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman	Genome Biol	2002	12184808	Yes
1180	1891	1891.0	33.87	33.9	The regulation of E2F by pRB-family proteins.	N Dyson	Genes Dev	1998	9694791	No
1181	7559	1889.8	1807.34	451.8	Cancer Statistics, 2021.	Rebecca L Siegel, Kimberly D Miller, Hannah E Fuchs, Ahmedin Jemal	CA Cancer J Clin	2021	33433946	Yes
1182	1889	1889.0	41.19	41.2	The mitogen-activated protein kinase signal transduction pathway.	R J Davis	J Biol Chem	1993	8325833	No
1183	1888	1888.0	37.05	37.0	Approaching the asymptote? Evolution and revolution in immunology.	C A Janeway	Cold Spring Harb Symp Quant Biol	1989	2700931	No
1184	3775	1887.5	86.63	43.3	The Fas death factor.	S Nagata, P Golstein	Science	1995	7533326	No
1185	1887	1887.0	0.0	0.0	The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides.	G S Manning	Q Rev Biophys	1978	353876	No
1186	1887	1887.0	39.01	39.0	The complex language of chromatin regulation during transcription.	Shelley L Berger	Nature	2007	17522673	No
1187	3773	1886.5	73.04	36.5	Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.	M Karin, Y Ben-Neriah	Annu Rev Immunol	2000	10837071	No
1188	1886	1886.0	46.31	46.3	Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver.	Scott L Friedman	Physiol Rev	2008	18195085	No
1189	1885	1885.0	0.0	0.0	Complete nucleotide sequence of the Escherichia coli plasmid pBR322.	J G Sutcliffe	Cold Spring Harb Symp Quant Biol	1979	383387	Yes
1190	5653	1884.3	106.97	35.7	Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.	Jason D Fontenot, Marc A Gavin, Alexander Y Rudensky	Nat Immunol	2003	12612578	Yes
1191	3768	1884.0	0.0	0.0	An efficient mRNA-dependent translation system from reticulocyte lysates.	H R Pelham, R J Jackson	Eur J Biochem	1976	823012	Yes
1192	1882	1882.0	45.47	45.5	The global health burden of infection-associated cancers in the year 2002.	Donald Maxwell Parkin	Int J Cancer	2006	16404738	Yes
1193	1880	1880.0	42.02	42.0	Neutrophils and immunity: challenges and opportunities.	Carl Nathan	Nat Rev Immunol	2006	16498448	No
1194	1879	1879.0	53.48	53.5	Flavonoids as antioxidants.	P G Pietta	J Nat Prod	2000	10924197	No
1195	1879	1879.0	0.0	0.0	The etiology of chondromalacia patellae.	R E Outerbridge	J Bone Joint Surg Br	1961	14038135	Yes
1196	1879	1879.0	46.13	46.1	Cancer chemoprevention with dietary phytochemicals.	Young-Joon Surh	Nat Rev Cancer	2003	14570043	No
1197	1878	1878.0	62.52	62.5	Physiological actions of taurine.	R J Huxtable	Physiol Rev	1992	1731369	No
1198	1878	1878.0	54.07	54.1	The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation.	G P Chrousos	N Engl J Med	1995	7715646	No
1199	1877	1877.0	60.13	60.1	Sick individuals and sick populations.	G Rose	Int J Epidemiol	1985	3872850	Yes
1200	1874	1874.0	0.0	0.0	High-speed scanning in human memory.	S Sternberg	Science	1966	5939936	Yes
1201	3744	1872.0	0.0	0.0	Mathematical model for studying genetic variation in terms of restriction endonucleases.	M Nei, W H Li	Proc Natl Acad Sci U S A	1979	291943	Yes
1202	3742	1871.0	84.82	42.4	Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.	T Miyashita, J C Reed	Cell	1995	7834749	Yes
1203	7482	1870.5	0.0	0.0	Antibiotic susceptibility testing by a standardized single disk method.	A W Bauer, W M Kirby, J C Sherris, M Turck	Am J Clin Pathol	1966	5325707	Yes
1204	1868	1868.0	43.95	44.0	Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome.	B L Wajchenberg	Endocr Rev	2000	11133069	No
1205	7466	1866.5	292.88	73.2	A simple technique for quantitation of low levels of DNA damage in individual cells.	N P Singh, M T McCoy, R R Tice, E L Schneider	Exp Cell Res	1988	3345800	Yes
1206	3733	1866.5	79.94	40.0	Raster3D: photorealistic molecular graphics.	E A Merritt, D J Bacon	Methods Enzymol	1997	18488322	Yes
1207	1866	1866.0	0.0	0.0	A theory of cerebellar cortex.	D Marr	J Physiol	1969	5784296	Yes
1208	1866	1866.0	37.85	37.9	DNA methylation and human disease.	Keith D Robertson	Nat Rev Genet	2005	16136652	No
1209	1866	1866.0	58.24	58.2	Global epidemiology of oral and oropharyngeal cancer.	Saman Warnakulasuriya	Oral Oncol	2009	18804401	No
1210	1865	1865.0	59.82	59.8	Calculation of substrate oxidation rates in vivo from gaseous exchange.	K N Frayn	J Appl Physiol Respir Environ Exerc Physiol	1983	6618956	Yes
1211	1864	1864.0	59.98	60.0	Epidemiological features of chronic low-back pain.	G B Andersson	Lancet	1999	10470716	No
1212	1864	1864.0	33.41	33.4	Mechanisms of alternative pre-messenger RNA splicing.	Douglas L Black	Annu Rev Biochem	2003	12626338	No
1213	3727	1863.5	100.32	50.2	Building better batteries.	M Armand, J-M Tarascon	Nature	2008	18256660	No
1214	3726	1863.0	104.38	52.2	The unfolded protein response: from stress pathway to homeostatic regulation.	Peter Walter, David Ron	Science	2011	22116877	No
1215	3724	1862.0	89.62	44.8	The future of genetic studies of complex human diseases.	N Risch, K Merikangas	Science	1996	8801636	Yes
1216	13024	1860.6	306.71	43.8	Induction of pluripotent stem cells from adult human fibroblasts by defined factors.	Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka	Cell	2007	18035408	Yes
1217	3719	1859.5	117.62	58.8	Efficient pseudopotentials for plane-wave calculations.	Troullier, Martins	Phys Rev B Condens Matter	1991	9997467	Yes
1218	1859	1859.0	0.0	0.0	A simple fluorometric assay for lipoperoxide in blood plasma.	K Yagi	Biochem Med	1976	962904	Yes
1219	1859	1859.0	45.15	45.1	The dawning era of polymer therapeutics.	Ruth Duncan	Nat Rev Drug Discov	2003	12750738	No
1220	1858	1858.0	0.0	0.0	Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system.	D M Neville	J Biol Chem	1971	5127429	Yes
1221	1858	1858.0	40.93	40.9	A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics.	J SantaLucia	Proc Natl Acad Sci U S A	1998	9465037	Yes
1222	1857	1857.0	50.97	51.0	A computational procedure for determining energetically favorable binding sites on biologically important macromolecules.	P J Goodford	J Med Chem	1985	3892003	Yes
1223	3714	1857.0	119.99	60.0	Macrophage plasticity and polarization: in vivo veritas.	Antonio Sica, Alberto Mantovani	J Clin Invest	2012	22378047	No
1224	1856	1856.0	36.17	36.2	Notch signalling: a simple pathway becomes complex.	Sarah J Bray	Nat Rev Mol Cell Biol	2006	16921404	No
1225	1854	1854.0	41.21	41.2	Cellular mechanisms of insulin resistance.	G I Shulman	J Clin Invest	2000	10903330	No
1226	9269	1853.8	222.34	44.5	Development and testing of a general amber force field.	Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A Case	J Comput Chem	2004	15116359	Yes
1227	7413	1853.2	253.98	63.5	Reporting results of cancer treatment.	A B Miller, B Hoogstraten, M Staquet, A Winkler	Cancer	1981	7459811	Yes
1228	1853	1853.0	62.73	62.7	Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium.	Sergio Pecorelli	Int J Gynaecol Obstet	2009	19367689	No
1229	1852	1852.0	48.8	48.8	Hepatitis B virus infection.	W M Lee	N Engl J Med	1997	9392700	No
1230	3701	1850.5	106.28	53.1	Autophagy: renovation of cells and tissues.	Noboru Mizushima, Masaaki Komatsu	Cell	2011	22078875	No
1231	1848	1848.0	63.16	63.2	Guided Search 2.0 A revised model of visual search.	J M Wolfe	Psychon Bull Rev	1994	24203471	Yes
1232	1846	1846.0	43.58	43.6	Targeting PI3K signalling in cancer: opportunities, challenges and limitations.	Jeffrey A Engelman	Nat Rev Cancer	2009	19629070	No
1233	1845	1845.0	54.77	54.8	Inhibited spontaneous emission in solid-state physics and electronics.	Yablonovitch	Phys Rev Lett	1987	10034639	Yes
1234	5533	1844.3	0.0	0.0	A rapid method for the isolation of functional thymus-derived murine lymphocytes.	M H Julius, E Simpson, L A Herzenberg	Eur J Immunol	1973	4587740	Yes
1235	3688	1844.0	0.0	0.0	Immunoassay of insulin with insulin-antibody precipitate.	C N Hales, P J Randle	Biochem J	1963	13952078	Yes
1236	5528	1842.7	125.38	41.8	A new statistical method for haplotype reconstruction from population data.	M Stephens, N J Smith, P Donnelly	Am J Hum Genet	2001	11254454	Yes
1237	3683	1841.5	125.19	62.6	Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.	G Di Chiara, A Imperato	Proc Natl Acad Sci U S A	1988	2899326	Yes
1238	1841	1841.0	52.33	52.3	Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.	A Dunaif	Endocr Rev	1997	9408743	No
1239	1841	1841.0	0.0	0.0	A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field.	D A Robinson	IEEE Trans Biomed Eng	1963	14121113	Yes
1240	3682	1841.0	85.87	42.9	Liver fibrosis.	Ramón Bataller, David A Brenner	J Clin Invest	2005	15690074	No
1241	1841	1841.0	81.6	81.6	What's in a name? Qualitative description revisited.	Margarete Sandelowski	Res Nurs Health	2010	20014004	Yes
1242	3681	1840.5	96.7	48.4	Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering	Nie, Emory	Science	1997	9027306	Yes
1243	1840	1840.0	45.62	45.6	The hydrogen bond in the solid state.	Thomas Steiner	Angew Chem Int Ed Engl	2002	12491444	Yes
1244	1839	1839.0	68.52	68.5	Recognition-by-components: a theory of human image understanding.	Irving Biederman	Psychol Rev	1987	3575582	Yes
1245	3678	1839.0	126.43	63.2	Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine.	M H Zweig, G Campbell	Clin Chem	1993	8472349	No
1246	5516	1838.7	138.77	46.3	Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.	Z N Oltvai, C L Milliman, S J Korsmeyer	Cell	1993	8358790	Yes
1247	5515	1838.3	181.74	60.6	Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data.	L Excoffier, P E Smouse, J M Quattro	Genetics	1992	1644282	Yes
1248	7350	1837.5	0.0	0.0	Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.	D J Sahn, A DeMaria, J Kisslo, A Weyman	Circulation	1978	709763	Yes
1249	7344	1836.0	355.45	88.9	The Satisfaction With Life Scale.	E Diener, R A Emmons, R J Larsen, S Griffin	J Pers Assess	1985	16367493	Yes
1250	1833	1833.0	47.67	47.7	What is cognitive reserve? Theory and research application of the reserve concept.	Yaakov Stern	J Int Neuropsychol Soc	2002	11939702	No
1251	1831	1831.0	68.04	68.0	Physiological aspects of primary hypertension.	B Folkow	Physiol Rev	1982	6461865	No
1252	1831	1831.0	41.65	41.6	DNA topoisomerases.	J C Wang	Annu Rev Biochem	1996	8811192	No
1253	1831	1831.0	38.09	38.1	Mechanisms of cancer drug resistance.	Michael M Gottesman	Annu Rev Med	2002	11818492	No
1254	14647	1830.9	414.2	51.8	Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.	R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A Erlich	Science	1988	2448875	Yes
1255	1828	1828.0	37.21	37.2	Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls.	R J Kaufman	Genes Dev	1999	10346810	No
1256	3656	1828.0	70.86	35.4	SIFT: Predicting amino acid changes that affect protein function.	Pauline C Ng, Steven Henikoff	Nucleic Acids Res	2003	12824425	Yes
1257	1828	1828.0	56.29	56.3	Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events?	George A Bonanno	Am Psychol	2004	14736317	No
1258	3656	1828.0	86.25	43.1	PRODRG: a tool for high-throughput crystallography of protein-ligand complexes.	Alexander W Schüttelkopf, Daan M F van Aalten	Acta Crystallogr D Biol Crystallogr	2004	15272157	Yes
1259	1827	1827.0	66.23	66.2	Why patients use alternative medicine: results of a national study.	J A Astin	JAMA	1998	9605899	Yes
1260	3652	1826.0	75.88	37.9	Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia.	C D Nobes, A Hall	Cell	1995	7536630	Yes
1261	1826	1826.0	41.68	41.7	Global cancer statistics in the year 2000.	D M Parkin	Lancet Oncol	2001	11905707	No
1262	5476	1825.3	141.55	47.2	Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.	G S Hotamisligil, N S Shargill, B M Spiegelman	Science	1993	7678183	Yes
1263	1825	1825.0	0.0	0.0	A classification of hand preference by association analysis.	M Annett	Br J Psychol	1970	5457503	Yes
1264	7300	1825.0	184.71	46.2	Cancer-related inflammation.	Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill	Nature	2008	18650914	No
1265	3643	1821.5	120.62	60.3	Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease.	R A DeFronzo, E Ferrannini	Diabetes Care	1991	2044434	No
1266	1821	1821.0	0.0	0.0	Positional information and the spatial pattern of cellular differentiation.	L Wolpert	J Theor Biol	1969	4390734	Yes
1267	3641	1820.5	81.98	41.0	Issues and challenges facing rechargeable lithium batteries.	J M Tarascon, M Armand	Nature	2001	11713543	Yes
1268	7278	1819.5	177.56	44.4	Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels.	A Shevchenko, M Wilm, O Vorm, M Mann	Anal Chem	1996	8779443	Yes
1269	3634	1817.0	67.56	33.8	Rho GTPases in cell biology.	Sandrine Etienne-Manneville, Alan Hall	Nature	2002	12478284	No
1270	1815	1815.0	67.11	67.1	Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury.	D R Janero	Free Radic Biol Med	1990	2079232	No
1271	7259	1814.8	158.56	39.6	MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform.	Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi Miyata	Nucleic Acids Res	2002	12136088	Yes
1272	1814	1814.0	39.3	39.3	Exploring complex networks.	S H Strogatz	Nature	2001	11258382	No
1273	1814	1814.0	44.66	44.7	Episodic memory: from mind to brain.	Endel Tulving	Annu Rev Psychol	2002	11752477	Yes
1274	7251	1812.8	314.74	78.7	jModelTest 2: more models, new heuristics and parallel computing.	Diego Darriba, Guillermo L Taboada, Ramón Doallo, David Posada	Nat Methods	2012	22847109	Yes
1275	1812	1812.0	43.39	43.4	The mitochondrial permeability transition pore and its role in cell death.	M Crompton	Biochem J	1999	10393078	No
1276	1811	1811.0	0.0	0.0	Dendritic organization in the neurons of the visual and motor cortices of the cat.	D A Sholl	J Anat	1953	13117757	Yes
1277	1811	1811.0	0.0	0.0	The influence of some cations on an adenosine triphosphatase from peripheral nerves.	J C Skou	Biochim Biophys Acta	1957	13412736	Yes
1278	1811	1811.0	59.57	59.6	Grounded cognition.	Lawrence W Barsalou	Annu Rev Psychol	2008	17705682	No
1279	1809	1809.0	44.86	44.9	Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials.	Fiona Turnbull	Lancet	2003	14615107	Yes
1280	1808	1808.0	50.87	50.9	Trail Making Test A and B: normative data stratified by age and education.	Tom N Tombaugh	Arch Clin Neuropsychol	2004	15010086	Yes
1281	1803	1803.0	0.0	0.0	Protein denaturation.	C Tanford	Adv Protein Chem	1968	4882248	No
1282	1803	1803.0	51.8	51.8	Introduction and General Overview of Cyclodextrin Chemistry.	József Szejtli	Chem Rev	1998	11848947	Yes
1283	1801	1801.0	0.0	0.0	Transplacental carcinogenesis by stilbestrol.	J Folkman	N Engl J Med	1971	5556579	Yes
1284	5402	1800.7	173.78	57.9	Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions.	Aleksandr V Marenich, Christopher J Cramer, Donald G Truhlar	J Phys Chem B	2009	19366259	Yes
1285	7201	1800.2	183.35	45.8	Epithelial-mesenchymal transitions in development and disease.	Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela Nieto	Cell	2009	19945376	No
1286	1798	1798.0	49.9	49.9	Determination of minimum inhibitory concentrations.	J M Andrews	J Antimicrob Chemother	2001	11420333	Yes
1287	3594	1797.0	81.49	40.7	Parkinson's disease: mechanisms and models.	William Dauer, Serge Przedborski	Neuron	2003	12971891	No
1288	1797	1797.0	0.0	0.0	On respiratory impairment in cancer cells.	O Warburg	Science	1956	13351639	Yes
1289	1796	1796.0	49.13	49.1	New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures.	R Y Tsien	Biochemistry	1980	6770893	Yes
1290	1796	1796.0	36.48	36.5	MicroRNA biogenesis: coordinated cropping and dicing.	V Narry Kim	Nat Rev Mol Cell Biol	2005	15852042	No
1291	1796	1796.0	41.82	41.8	Integrating cell-signalling pathways with NF-kappaB and IKK function.	Neil D Perkins	Nat Rev Mol Cell Biol	2007	17183360	No
1292	3591	1795.5	75.68	37.8	Identification of common molecular subsequences.	T F Smith, M S Waterman	J Mol Biol	1981	7265238	Yes
1293	1795	1795.0	0.0	0.0	Estimability and estimation in case-referent studies.	O Miettinen	Am J Epidemiol	1976	1251836	Yes
1294	1795	1795.0	82.39	82.4	Determinants of low birth weight: methodological assessment and meta-analysis.	M S Kramer	Bull World Health Organ	1987	3322602	No
1295	1794	1794.0	69.23	69.2	The emerging role of lncRNAs in cancer.	Maite Huarte	Nat Med	2015	26540387	No
1296	1793	1793.0	40.97	41.0	Fabrication of novel biomaterials through molecular self-assembly.	Shuguang Zhang	Nat Biotechnol	2003	14520402	No
1297	3586	1793.0	82.73	41.4	The DNA-damage response in human biology and disease.	Stephen P Jackson, Jiri Bartek	Nature	2009	19847258	No
1298	1793	1793.0	61.53	61.5	Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies.	Peter C Austin	Pharm Stat	2011	20925139	Yes
1299	1792	1792.0	54.59	54.6	An overview of brominated flame retardants in the environment.	Cynthia A de Wit	Chemosphere	2002	11999784	No
1300	1792	1792.0	44.57	44.6	The genetics of ageing.	Cynthia J Kenyon	Nature	2010	20336132	No
1301	1790	1790.0	58.56	58.6	Heavy metal intensification of DAB-based HRP reaction product.	J C Adams	J Histochem Cytochem	1981	7252134	Yes
1302	1790	1790.0	0.0	0.0	The measurement of volume changes in human limbs.	R J Whitney	J Physiol	1953	13085295	Yes
1303	1789	1789.0	0.0	0.0	Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal.	S Cohen	J Biol Chem	1962	13880319	Yes
1304	3578	1789.0	76.18	38.1	Cell death: critical control points.	Nika N Danial, Stanley J Korsmeyer	Cell	2004	14744432	No
1305	1789	1789.0	35.5	35.5	Cancer and the chemokine network.	Fran Balkwill	Nat Rev Cancer	2004	15229479	No
1306	3577	1788.5	92.53	46.3	Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.	K D McCarthy, J de Vellis	J Cell Biol	1980	6248568	Yes
1307	1788	1788.0	0.0	0.0	Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.	U Ungerstedt	Acta Physiol Scand Suppl	1971	4332693	Yes
1308	5363	1787.7	120.13	40.0	Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR.	Michael W Pfaffl, Graham W Horgan, Leo Dempfle	Nucleic Acids Res	2002	11972351	Yes
1309	3575	1787.5	86.32	43.2	Protein folding in the cell.	M J Gething, J Sambrook	Nature	1992	1731198	No
1310	1787	1787.0	41.34	41.3	The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.	Michael R Lieber	Annu Rev Biochem	2010	20192759	No
1311	1786	1786.0	46.74	46.7	Dengue and dengue hemorrhagic fever.	D J Gubler	Clin Microbiol Rev	1998	9665979	No
1312	3568	1784.0	0.0	0.0	Multiple receptors for dopamine.	J W Kebabian, D B Calne	Nature	1979	215920	No
1313	1784	1784.0	43.58	43.6	Python: a programming language for software integration and development.	M F Sanner	J Mol Graph Model	1999	10660911	Yes
1314	3566	1783.0	0.0	0.0	Maturation of the head of bacteriophage T4. I. DNA packaging events.	U K Laemmli, M Favre	J Mol Biol	1973	4204102	Yes
1315	1782	1782.0	68.98	69.0	Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review.	H U Wittchen	J Psychiatr Res	1994	8064641	No
1316	1780	1780.0	54.71	54.7	The atom economy--a search for synthetic efficiency.	B M Trost	Science	1991	1962206	Yes
1317	1780	1780.0	70.27	70.3	Predicting basal metabolic rate, new standards and review of previous work.	W N Schofield	Hum Nutr Clin Nutr	1985	4044297	Yes
1318	3557	1778.5	76.88	38.4	Monocyte and macrophage heterogeneity.	Siamon Gordon, Philip R Taylor	Nat Rev Immunol	2005	16322748	No
1319	1778	1778.0	62.41	62.4	A cortical network for directed attention and unilateral neglect.	M M Mesulam	Ann Neurol	1981	7032417	No
1320	3555	1777.5	101.65	50.8	Event-related EEG/MEG synchronization and desynchronization: basic principles.	G Pfurtscheller, F H Lopes da Silva	Clin Neurophysiol	1999	10576479	No
1321	12419	1774.1	447.72	64.0	Assessing the quality of reports of randomized clinical trials: is blinding necessary?	A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuay	Control Clin Trials	1996	8721797	Yes
1322	3547	1773.5	84.67	42.3	Neuronal oscillations in cortical networks.	György Buzsáki, Andreas Draguhn	Science	2004	15218136	No
1323	1772	1772.0	47.68	47.7	The comet assay for DNA damage and repair: principles, applications, and limitations.	Andrew R Collins	Mol Biotechnol	2004	15004294	No
1324	1772	1772.0	66.75	66.8	The Resonating Valence Bond State in La2CuO4 and Superconductivity.	P W Anderson	Science	1987	17818979	Yes
1325	5314	1771.3	102.22	34.1	Surfing the p53 network.	B Vogelstein, D Lane, A J Levine	Nature	2000	11099028	No
1326	1771	1771.0	49.76	49.8	Cell biology and molecular basis of denitrification.	W G Zumft	Microbiol Mol Biol Rev	1997	9409151	No
1327	1771	1771.0	48.01	48.0	Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic.	Robert E Marx	J Oral Maxillofac Surg	2003	12966493	Yes
1328	1769	1769.0	56.72	56.7	A new automated colorimetric method for measuring total oxidant status.	Ozcan Erel	Clin Biochem	2005	16214125	Yes
1329	1766	1766.0	42.93	42.9	Evolutionary relationship of DNA sequences in finite populations.	F Tajima	Genetics	1983	6628982	Yes
1330	1764	1764.0	36.41	36.4	Molecular regulation of vessel maturation.	Rakesh K Jain	Nat Med	2003	12778167	No
1331	3526	1763.0	80.08	40.0	Amino acid substitution matrices from protein blocks.	S Henikoff, J G Henikoff	Proc Natl Acad Sci U S A	1992	1438297	Yes
1332	1762	1762.0	55.76	55.8	Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.	M Zasloff	Proc Natl Acad Sci U S A	1987	3299384	Yes
1333	1762	1762.0	47.92	47.9	G proteins and dual control of adenylate cyclase.	A G Gilman	Cell	1984	6321035	Yes
1334	3524	1762.0	126.66	63.3	ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts.	M Gardes, T D Bruns	Mol Ecol	1993	8180733	Yes
1335	1762	1762.0	36.63	36.6	Structure and regulation of voltage-gated Ca2+ channels.	W A Catterall	Annu Rev Cell Dev Biol	2000	11031246	No
1336	1762	1762.0	42.54	42.5	Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures.	D Lavanchy	J Viral Hepat	2004	14996343	No
1337	3523	1761.5	0.0	0.0	New method for quantitative determination of uronic acids.	N Blumenkrantz, G Asboe-Hansen	Anal Biochem	1973	4269305	Yes
1338	1760	1760.0	58.83	58.8	Drugs of abuse: anatomy, pharmacology and function of reward pathways.	G F Koob	Trends Pharmacol Sci	1992	1604710	No
1339	1760	1760.0	0.0	0.0	Evolutionary rate at the molecular level.	M Kimura	Nature	1968	5637732	Yes
1340	8798	1759.6	216.97	43.4	Mapping and quantifying mammalian transcriptomes by RNA-Seq.	Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara Wold	Nat Methods	2008	18516045	Yes
1341	3519	1759.5	112.81	56.4	Understanding interobserver agreement: the kappa statistic.	Anthony J Viera, Joanne M Garrett	Fam Med	2005	15883903	Yes
1342	14065	1758.1	353.12	44.1	Electric field effect in atomically thin carbon films.	K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A Firsov	Science	2004	15499015	Yes
1343	1757	1757.0	61.4	61.4	The role of hormone receptors and GTP-regulatory proteins in membrane transduction.	M Rodbell	Nature	1980	6101906	Yes
1344	1757	1757.0	48.29	48.3	Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution.	H LeVine	Protein Sci	1993	8453378	Yes
1345	1757	1757.0	45.26	45.3	Pathogen recognition and inflammatory signaling in innate immune defenses.	Trine H Mogensen	Clin Microbiol Rev	2009	19366914	No
1346	3514	1757.0	134.68	67.3	miRBase: annotating high confidence microRNAs using deep sequencing data.	Ana Kozomara, Sam Griffiths-Jones	Nucleic Acids Res	2014	24275495	Yes
1347	1756	1756.0	46.74	46.7	Interleukin-6: an overview.	J Van Snick	Annu Rev Immunol	1990	2188664	No
1348	3512	1756.0	88.7	44.4	The biology of vascular endothelial growth factor.	N Ferrara, T Davis-Smyth	Endocr Rev	1997	9034784	No
1349	1756	1756.0	36.31	36.3	An extensively modified version of MolScript that includes greatly enhanced coloring capabilities.	R M Esnouf	J Mol Graph Model	1997	9385560	Yes
1350	3511	1755.5	97.09	48.5	Biofilms: survival mechanisms of clinically relevant microorganisms.	Rodney M Donlan, J William Costerton	Clin Microbiol Rev	2002	11932229	No
1351	1755	1755.0	57.61	57.6	Pineal melatonin: cell biology of its synthesis and of its physiological interactions.	R J Reiter	Endocr Rev	1991	1649044	No
1352	1755	1755.0	58.69	58.7	Large-scale neurocognitive networks and distributed processing for attention, language, and memory.	M M Mesulam	Ann Neurol	1990	2260847	No
1353	1755	1755.0	0.0	0.0	The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application.	S Hestrin	J Biol Chem	1949	18133390	Yes
1354	8774	1754.8	233.77	46.8	Global prevalence of diabetes: estimates for the year 2000 and projections for 2030.	Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary King	Diabetes Care	2004	15111519	Yes
1355	1754	1754.0	0.0	0.0	Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu.	M J Casadaban	J Mol Biol	1976	781293	Yes
1356	1753	1753.0	0.0	0.0	A personality scale of manifest anxiety.	J A Taylor	J Abnorm Psychol	1953	13052352	Yes
1357	1751	1751.0	44.82	44.8	The pathophysiology of tumor necrosis factors.	P Vassalli	Annu Rev Immunol	1992	1590993	No
1358	1751	1751.0	0.0	0.0	ATPase activity of myosin correlated with speed of muscle shortening.	M Bárány	J Gen Physiol	1967	4227924	Yes
1359	1750	1750.0	40.25	40.2	Steroid receptor regulated transcription of specific genes and gene networks.	K R Yamamoto	Annu Rev Genet	1985	3909942	No
1360	3500	1750.0	0.0	0.0	Receptive fields and functional architecture of monkey striate cortex.	D H Hubel, T N Wiesel	J Physiol	1968	4966457	Yes
1361	1750	1750.0	50.94	50.9	Multiple imputation: a primer.	J L Schafer	Stat Methods Med Res	1999	10347857	No
1362	1748	1748.0	35.82	35.8	The effect of infections on susceptibility to autoimmune and allergic diseases.	Jean-Francois Bach	N Engl J Med	2002	12239261	No
1363	3495	1747.5	0.0	0.0	A complementation analysis of the restriction and modification of DNA in Escherichia coli.	H W Boyer, D Roulland-Dussoix	J Mol Biol	1969	4896022	Yes
1364	3495	1747.5	134.72	67.4	Deciphering key features in protein structures with the new ENDscript server.	Xavier Robert, Patrice Gouet	Nucleic Acids Res	2014	24753421	Yes
1365	1746	1746.0	57.91	57.9	The crisis in antibiotic resistance.	H C Neu	Science	1992	1509257	No
1366	1746	1746.0	38.9	38.9	The synaptic vesicle cycle: a cascade of protein-protein interactions.	T C Südhof	Nature	1995	7791897	No
1367	1745	1745.0	73.73	73.7	The drug abuse screening test.	H A Skinner	Addict Behav	1982	7183189	Yes
1368	1745	1745.0	41.63	41.6	Type III protein secretion systems in bacterial pathogens of animals and plants.	C J Hueck	Microbiol Mol Biol Rev	1998	9618447	No
1369	1744	1744.0	41.3	41.3	The retinal pigment epithelium in visual function.	Olaf Strauss	Physiol Rev	2005	15987797	No
1370	1743	1743.0	0.0	0.0	Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals.	J N Dumont	J Morphol	1972	4109871	Yes
1371	3486	1743.0	0.0	0.0	Variations in the pattern of pubertal changes in boys.	W A Marshall, J M Tanner	Arch Dis Child	1970	5440182	Yes
1372	3485	1742.5	86.8	43.4	Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.	Christian Haass, Dennis J Selkoe	Nat Rev Mol Cell Biol	2007	17245412	No
1373	3479	1739.5	93.24	46.6	Prediction of protein antigenic determinants from amino acid sequences.	T P Hopp, K R Woods	Proc Natl Acad Sci U S A	1981	6167991	Yes
1374	3478	1739.0	86.49	43.2	Matrix metalloproteinases.	H Nagase, J F Woessner	J Biol Chem	1999	10419448	No
1375	1739	1739.0	47.52	47.5	Molecular dissection of reactive astrogliosis and glial scar formation.	Michael V Sofroniew	Trends Neurosci	2009	19782411	No
1376	1738	1738.0	39.55	39.5	Recognition of microorganisms and activation of the immune response.	Ruslan Medzhitov	Nature	2007	17943118	No
1377	1737	1737.0	64.02	64.0	UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure.	D W Russell	J Pers Assess	1996	8576833	Yes
1378	1736	1736.0	32.76	32.8	Cellular roles of DNA topoisomerases: a molecular perspective.	James C Wang	Nat Rev Mol Cell Biol	2002	12042765	No
1379	19081	1734.6	488.39	44.4	PLINK: a tool set for whole-genome association and population-based linkage analyses.	Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C Sham	Am J Hum Genet	2007	17701901	Yes
1380	1733	1733.0	0.0	0.0	Dynamic properties of mammalian skeletal muscles.	R I Close	Physiol Rev	1972	4256989	No
1381	1733	1733.0	31.95	31.9	CD4+ CD25+ suppressor T cells: more questions than answers.	Ethan M Shevach	Nat Rev Immunol	2002	12093005	No
1382	3465	1732.5	94.36	47.2	Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction.	K B Mullis, F A Faloona	Methods Enzymol	1987	3431465	Yes
1383	1732	1732.0	0.0	0.0	Areas, volumes, packing and protein structure.	F M Richards	Annu Rev Biophys Bioeng	1977	326146	No
1384	17318	1731.8	546.83	54.7	Measurement of protein using bicinchoninic acid.	P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C Klenk	Anal Biochem	1985	3843705	Yes
1385	5193	1731.0	113.19	37.7	Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons.	A Nicholls, K A Sharp, B Honig	Proteins	1991	1758883	Yes
1386	1731	1731.0	62.18	62.2	Cyclosporine.	B D Kahan	N Engl J Med	1989	2687689	No
1387	5193	1731.0	160.79	53.6	Estimating the mean and variance from the median, range, and the size of a sample.	Stela Pudar Hozo, Benjamin Djulbegovic, Iztok Hozo	BMC Med Res Methodol	2005	15840177	Yes
1388	3455	1727.5	0.0	0.0	Determination of malonaldehyde precursor in tissues by thiobarbituric acid test.	M Mihara, M Uchiyama	Anal Biochem	1978	655387	Yes
1389	3455	1727.5	91.07	45.5	Cloned glutamate receptors.	M Hollmann, S Heinemann	Annu Rev Neurosci	1994	8210177	No
1390	1726	1726.0	0.0	0.0	Why genes in pieces?	W Gilbert	Nature	1978	622185	Yes
1391	3452	1726.0	103.72	51.9	Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being.	James J Gross, Oliver P John	J Pers Soc Psychol	2003	12916575	Yes
1392	6902	1725.5	134.96	33.7	Transformation of intact yeast cells treated with alkali cations.	H Ito, Y Fukuda, K Murata, A Kimura	J Bacteriol	1983	6336730	Yes
1393	1725	1725.0	57.49	57.5	Serum albumin.	T Peters	Adv Protein Chem	1985	3904348	No
1394	1725	1725.0	45.36	45.4	From sensation to cognition.	M M Mesulam	Brain	1998	9648540	No
1395	1724	1724.0	54.32	54.3	Glutamate: a neurotransmitter in mammalian brain.	F Fonnum	J Neurochem	1984	6139418	No
1396	1724	1724.0	97.68	97.7	Metazoan MicroRNAs.	David P Bartel	Cell	2018	29570994	No
1397	5169	1723.0	156.89	52.3	Atrial fibrillation as an independent risk factor for stroke: the Framingham Study.	P A Wolf, R D Abbott, W B Kannel	Stroke	1991	1866765	Yes
1398	1723	1723.0	67.86	67.9	Pro-resolving lipid mediators are leads for resolution physiology.	Charles N Serhan	Nature	2014	24899309	No
1399	6891	1722.8	136.56	34.1	Stem cells, cancer, and cancer stem cells.	T Reya, S J Morrison, M F Clarke, I L Weissman	Nature	2001	11689955	No
1400	3441	1720.5	108.47	54.2	Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference.	Stephen M Smith, Thomas E Nichols	Neuroimage	2009	18501637	Yes
1401	1718	1718.0	0.0	0.0	The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers.	R Ross	J Cell Biol	1971	4327464	Yes
1402	5154	1718.0	230.09	76.7	Some statistical methods useful in circulation research.	S Wallenstein, C L Zucker, J L Fleiss	Circ Res	1980	7379260	Yes
1403	1718	1718.0	56.55	56.5	Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders.	Berislav V Zlokovic	Nat Rev Neurosci	2011	22048062	No
1404	1717	1717.0	92.89	92.9	Abiotic Stress Signaling and Responses in Plants.	Jian-Kang Zhu	Cell	2016	27716505	No
1405	1716	1716.0	57.1	57.1	Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes.	C E Mogensen	N Engl J Med	1984	6690964	Yes
1406	1716	1716.0	40.34	40.3	Solvent-accessible surfaces of proteins and nucleic acids.	M L Connolly	Science	1983	6879170	Yes
1407	3432	1716.0	125.33	62.7	Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants.	Sarvajeet Singh Gill, Narendra Tuteja	Plant Physiol Biochem	2010	20870416	No
1408	1715	1715.0	0.0	0.0	Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.	A Krishan	J Cell Biol	1975	49354	Yes
1409	1715	1715.0	0.0	0.0	Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry.	M Wong-Riley	Brain Res	1979	223730	Yes
1410	3430	1715.0	72.88	36.4	Integrin signaling.	F G Giancotti, E Ruoslahti	Science	1999	10446041	No
1411	1714	1714.0	0.0	0.0	Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.	E M Witkin	Bacteriol Rev	1976	795416	No
1412	3424	1712.0	106.26	53.1	Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability.	F Denizot, R Lang	J Immunol Methods	1986	3486233	Yes
1413	1712	1712.0	0.0	0.0	Determination of free amino groups in proteins by trinitrobenzenesulfonic acid.	A F Habeeb	Anal Biochem	1966	4161471	Yes
1414	3424	1712.0	134.29	67.1	Assays of glutathione peroxidase.	L Flohé, W A Günzler	Methods Enzymol	1984	6727659	Yes
1415	1712	1712.0	35.19	35.2	Points of control in inflammation.	Carl Nathan	Nature	2002	12490957	No
1416	1712	1712.0	41.87	41.9	Clinical application of C-reactive protein for cardiovascular disease detection and prevention.	Paul M Ridker	Circulation	2003	12551853	No
1417	1711	1711.0	0.0	0.0	The general adaptation syndrome and the diseases of adaptation.	H Selye	J Clin Endocrinol Metab	1946	21025115	Yes
1418	5132	1710.7	108.8	36.3	A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays.	Zhang, Chung, Oldenburg	J Biomol Screen	1999	10838414	Yes
1419	3421	1710.5	0.0	0.0	The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent.	A E Bolton, W M Hunter	Biochem J	1973	4733239	Yes
1420	1708	1708.0	0.0	0.0	Chromatin structure: a repeating unit of histones and DNA.	R D Kornberg	Science	1974	4825889	Yes
1421	1708	1708.0	45.6	45.6	Chlorpromazine equivalent doses for the newer atypical antipsychotics.	Scott W Woods	J Clin Psychiatry	2003	12823080	No
1422	1707	1707.0	49.78	49.8	Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996.	E M Wassermann	Electroencephalogr Clin Neurophysiol	1998	9474057	No
1423	1707	1707.0	35.78	35.8	Protein homology detection by HMM-HMM comparison.	Johannes Söding	Bioinformatics	2005	15531603	Yes
1424	1706	1706.0	59.13	59.1	Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?	B Halliwell	Lancet	1994	7915779	No
1425	1706	1706.0	46.51	46.5	Oxidative stress hypothesis in Alzheimer's disease.	W R Markesbery	Free Radic Biol Med	1997	9165306	No
1426	1704	1704.0	44.48	44.5	Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.	G C Walker	Microbiol Rev	1984	6371470	No
1427	1704	1704.0	36.05	36.0	Excitatory actions of gaba during development: the nature of the nurture.	Yehezkel Ben-Ari	Nat Rev Neurosci	2002	12209121	No
1428	1703	1703.0	46.92	46.9	Leptospirosis.	P N Levett	Clin Microbiol Rev	2001	11292640	No
1429	1702	1702.0	31.62	31.6	How eukaryotic transcriptional activators work.	M Ptashne	Nature	1988	3050531	No
1430	1701	1701.0	45.75	45.8	Integrins.	E Ruoslahti	J Clin Invest	1991	1985087	No
1431	1701	1701.0	0.0	0.0	Mode of cell migration to the superficial layers of fetal monkey neocortex.	P Rakic	J Comp Neurol	1972	4624784	Yes
1432	3402	1701.0	0.0	0.0	A "Direct-Coloring" Thiocholine Method For Cholinesterases.	M J Karnovsky, L Roots	J Histochem Cytochem	1964	14187330	Yes
1433	1700	1700.0	0.0	0.0	Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate.	J Spizizen	Proc Natl Acad Sci U S A	1958	16590310	Yes
1434	1699	1699.0	0.0	0.0	A graphic method for the determination and presentation of binding parameters in a complex system.	H E Rosenthal	Anal Biochem	1967	6048188	Yes
1435	1698	1698.0	57.46	57.5	Cognitive reserve.	Yaakov Stern	Neuropsychologia	2009	19467352	No
1436	3395	1697.5	72.99	36.5	Insulin signalling and the regulation of glucose and lipid metabolism.	A R Saltiel, C R Kahn	Nature	2001	11742412	Yes
1437	1697	1697.0	49.01	49.0	Perceptual symbol systems.	L W Barsalou	Behav Brain Sci	1999	11301525	No
1438	1697	1697.0	42.85	42.9	Adipose tissue, adipokines, and inflammation.	Giamila Fantuzzi	J Allergy Clin Immunol	2005	15867843	No
1439	1697	1697.0	45.94	45.9	Oxidative stress and neurodegeneration: where are we now?	Barry Halliwell	J Neurochem	2006	16805774	No
1440	11875	1696.4	293.27	41.9	Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.	William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan	N Engl J Med	2002	11832527	Yes
1441	5087	1695.7	137.29	45.8	The metabolic syndrome--a new worldwide definition.	K George M M Alberti, Paul Zimmet, Jonathan Shaw	Lancet	2005	16182882	Yes
1442	3390	1695.0	0.0	0.0	Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation.	R L Heath, L Packer	Arch Biochem Biophys	1968	5655425	Yes
1443	3390	1695.0	91.29	45.6	The mirror-neuron system.	Giacomo Rizzolatti, Laila Craighero	Annu Rev Neurosci	2004	15217330	No
1444	10168	1694.7	303.3	50.6	Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication.	Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E Walters	Arch Gen Psychiatry	2005	15939837	Yes
1445	6770	1692.5	0.0	0.0	Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.	E A Jaffe, R L Nachman, C G Becker, C R Minick	J Clin Invest	1973	4355998	Yes
1446	3383	1691.5	102.89	51.4	Molecular mechanisms and clinical applications of angiogenesis.	Peter Carmeliet, Rakesh K Jain	Nature	2011	21593862	No
1447	3381	1690.5	93.85	46.9	Biochemistry of multidrug resistance mediated by the multidrug transporter.	M M Gottesman, I Pastan	Annu Rev Biochem	1993	8102521	No
1448	1690	1690.0	40.68	40.7	The molecular genetics of cancer.	J M Bishop	Science	1987	3541204	No
1449	1690	1690.0	0.0	0.0	The statistical analysis of enzyme kinetic data.	W W Cleland	Adv Enzymol Relat Areas Mol Biol	1967	4881884	No
1450	5065	1688.3	159.91	53.3	Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.	H Esterbauer, R J Schaur, H Zollner	Free Radic Biol Med	1991	1937131	No
1451	1688	1688.0	53.64	53.6	The stress response in fish.	S E Wendelaar Bonga	Physiol Rev	1997	9234959	No
1452	3376	1688.0	87.99	44.0	Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes.	Steven E Nissen, Kathy Wolski	N Engl J Med	2007	17517853	Yes
1453	1687	1687.0	38.18	38.2	Effects of cytochalasin and phalloidin on actin.	J A Cooper	J Cell Biol	1987	3312229	No
1454	1687	1687.0	0.0	0.0	Cognitive maps in rats and men.	E C Tolman	Psychol Rev	1948	18870876	Yes
1455	3373	1686.5	102.54	51.3	Mechanisms of salinity tolerance.	Rana Munns, Mark Tester	Annu Rev Plant Biol	2008	18444910	No
1456	1686	1686.0	60.36	60.4	Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts).	G G Glenner	N Engl J Med	1980	6154243	No
1457	1686	1686.0	84.17	84.2	The brain's default mode network.	Marcus E Raichle	Annu Rev Neurosci	2015	25938726	No
1458	1685	1685.0	0.0	0.0	The micronucleus test.	W Schmid	Mutat Res	1975	48190	Yes
1459	1683	1683.0	0.0	0.0	Chromatographic Separation Of Human Brain Gangliosides.	L Svennerholm	J Neurochem	1963	14066623	Yes
1460	1683	1683.0	47.63	47.6	Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.	Ralph A Defronzo	Diabetes	2009	19336687	No
1461	1682	1682.0	0.0	0.0	Carbonic anhydrase: chemistry, physiology, and inhibition.	T H Maren	Physiol Rev	1967	4964060	No
1462	5045	1681.7	134.13	44.7	Median-joining networks for inferring intraspecific phylogenies.	H J Bandelt, P Forster, A Röhl	Mol Biol Evol	1999	10331250	Yes
1463	16816	1681.6	535.23	53.5	The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.	F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S Luthra	Arthritis Rheum	1988	3358796	Yes
1464	1680	1680.0	63.48	63.5	Simple proton spectroscopic imaging.	W T Dixon	Radiology	1984	6089263	Yes
1465	1680	1680.0	47.59	47.6	Porous scaffold design for tissue engineering.	Scott J Hollister	Nat Mater	2005	16003400	No
1466	1679	1679.0	0.0	0.0	The inverse care law.	J T Hart	Lancet	1971	4100731	Yes
1467	3358	1679.0	145.05	72.5	A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity.	J G Snodgrass, M Vanderwart	J Exp Psychol Hum Learn	1980	7373248	Yes
1468	1679	1679.0	0.0	0.0	Plastic Embedding Mixtures For Use In Electron Microscopy.	H H Mollenhauer	Stain Technol	1964	14127791	Yes
1469	1679	1679.0	0.0	0.0	The theory and applications of the exchange of inert gas at the lungs and tissues.	S S Kety	Pharmacol Rev	1951	14833874	Yes
1470	1678	1678.0	0.0	0.0	The relationship between the spleen colony-forming cell and the haemopoietic stem cell.	R Schofield	Blood Cells	1978	747780	Yes
1471	1678	1678.0	64.22	64.2	Modeling and variable selection in epidemiologic analysis.	S Greenland	Am J Public Health	1989	2916724	Yes
1472	3355	1677.5	85.87	42.9	Quantum dot bioconjugates for ultrasensitive nonisotopic detection.	W C Chan, S Nie	Science	1998	9748158	Yes
1473	1676	1676.0	33.39	33.4	Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.	Judith Campisi	Cell	2005	15734683	No
1474	5027	1675.7	115.9	38.6	Inflammation and atherosclerosis.	Peter Libby, Paul M Ridker, Attilio Maseri	Circulation	2002	11877368	No
1475	3350	1675.0	110.48	55.2	Role of free radicals and catalytic metal ions in human disease: an overview.	B Halliwell, J M Gutteridge	Methods Enzymol	1990	2172697	No
1476	1675	1675.0	36.16	36.2	Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury.	S L Friedman	J Biol Chem	2000	10644669	No
1477	1674	1674.0	38.73	38.7	The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.	D M Kingsley	Genes Dev	1994	8299934	No
1478	1674	1674.0	41.26	41.3	Growth of the plant cell wall.	Daniel J Cosgrove	Nat Rev Mol Cell Biol	2005	16261190	No
1479	1674	1674.0	48.44	48.4	Systemic lupus erythematosus.	George C Tsokos	N Engl J Med	2011	22129255	No
1480	3346	1673.0	0.0	0.0	A fluorometric method for determination of oxidized and reduced glutathione in tissues.	P J Hissin, R Hilf	Anal Biochem	1976	962076	Yes
1481	1672	1672.0	51.81	51.8	Social relationships and health.	Sheldon Cohen	Am Psychol	2004	15554821	No
1482	3343	1671.5	0.0	0.0	Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature.	J Marmur, P Doty	J Mol Biol	1962	14470099	Yes
1483	1671	1671.0	0.0	0.0	Drugs which inhibit prostaglandin biosynthesis.	R J Flower	Pharmacol Rev	1974	4208101	Yes
1484	3341	1670.5	86.08	43.0	Protein structure prediction on the Web: a case study using the Phyre server.	Lawrence A Kelley, Michael J E Sternberg	Nat Protoc	2009	19247286	Yes
1485	1670	1670.0	58.12	58.1	Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.	A H Conney	Cancer Res	1982	6814745	No
1486	1670	1670.0	47.52	47.5	Oxidative stress: oxidants and antioxidants.	H Sies	Exp Physiol	1997	9129943	No
1487	3339	1669.5	83.98	42.0	Receptors for purines and pyrimidines.	V Ralevic, G Burnstock	Pharmacol Rev	1998	9755289	No
1488	1669	1669.0	0.0	0.0	Method for the determination of hexosamines in tissues.	N F Boas	J Biol Chem	1953	13117829	Yes
1489	1669	1669.0	46.12	46.1	What we can do and what we cannot do with fMRI.	Nikos K Logothetis	Nature	2008	18548064	No
1490	10012	1668.7	282.86	47.1	Positional cloning of the mouse obese gene and its human homologue.	Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M Friedman	Nature	1994	7984236	Yes
1491	5005	1668.3	191.1	63.7	Molecular mechanisms of epithelial-mesenchymal transition.	Samy Lamouille, Jian Xu, Rik Derynck	Nat Rev Mol Cell Biol	2014	24556840	No
1492	1668	1668.0	0.0	0.0	Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.	J A Miller	Cancer Res	1970	4915745	No
1493	1668	1668.0	39.27	39.3	Tumor angiogenesis.	Robert S Kerbel	N Engl J Med	2008	18463380	No
1494	1668	1668.0	37.93	37.9	The hippo signaling pathway in development and cancer.	Duojia Pan	Dev Cell	2010	20951342	No
1495	3334	1667.0	86.73	43.4	Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation.	M A Nitsche, W Paulus	J Physiol	2000	10990547	Yes
1496	1667	1667.0	58.97	59.0	Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope.	Lutz Ackermann	Chem Rev	2011	21391562	Yes
1497	3334	1667.0	104.89	52.4	Oncology meets immunology: the cancer-immunity cycle.	Daniel S Chen, Ira Mellman	Immunity	2013	23890059	No
1498	1666	1666.0	0.0	0.0	Pedigrees of some mutant strains of Escherichia coli K-12.	B J Bachmann	Bacteriol Rev	1972	4568763	No
1499	1666	1666.0	68.35	68.3	Negative symptoms in schizophrenia. Definition and reliability.	N C Andreasen	Arch Gen Psychiatry	1982	7165477	Yes
1500	1666	1666.0	38.19	38.2	Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems.	S A Bustin	J Mol Endocrinol	2002	12200227	No
1501	1665	1665.0	65.79	65.8	Antibiotics in the aquatic environment--a review--part I.	Klaus Kümmerer	Chemosphere	2009	19185900	No
1502	3329	1664.5	123.75	61.9	Regulation of microRNA biogenesis.	Minju Ha, V Narry Kim	Nat Rev Mol Cell Biol	2014	25027649	No
1503	3328	1664.0	82.23	41.1	Origins and Mechanisms of miRNAs and siRNAs.	Richard W Carthew, Erik J Sontheimer	Cell	2009	19239886	No
1504	3325	1662.5	71.31	35.7	Why do cancers have high aerobic glycolysis?	Robert A Gatenby, Robert J Gillies	Nat Rev Cancer	2004	15516961	No
1505	3324	1662.0	171.68	85.8	Interrater reliability of a modified Ashworth scale of muscle spasticity.	R W Bohannon, M B Smith	Phys Ther	1987	3809245	Yes
1506	1661	1661.0	30.98	31.0	Cyclin-dependent kinases: engines, clocks, and microprocessors.	D O Morgan	Annu Rev Cell Dev Biol	1997	9442875	No
1507	3321	1660.5	0.0	0.0	Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.	M Grunstein, D S Hogness	Proc Natl Acad Sci U S A	1975	1105573	Yes
1508	1658	1658.0	88.21	88.2	Subjective well-being.	E Diener	Psychol Bull	1984	6399758	No
1509	6630	1657.5	153.64	38.4	Use of T7 RNA polymerase to direct expression of cloned genes.	F W Studier, A H Rosenberg, J J Dunn, J W Dubendorff	Methods Enzymol	1990	2199796	Yes
1510	1657	1657.0	0.0	0.0	RNA-dependent DNA polymerase in virions of RNA tumour viruses.	D Baltimore	Nature	1970	4316300	Yes
1511	1657	1657.0	38.45	38.5	NADPH oxidase: an update.	B M Babior	Blood	1999	10029572	No
1512	3312	1656.0	78.95	39.5	The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.	P Angel, M Karin	Biochim Biophys Acta	1991	1751545	No
1513	1656	1656.0	0.0	0.0	Computerized transverse axial scanning (tomography). 1. Description of system.	G N Hounsfield	Br J Radiol	1973	4757352	Yes
1514	1656	1656.0	33.2	33.2	The synaptic vesicle cycle.	Thomas C Sudhof	Annu Rev Neurosci	2004	15217342	No
1515	3311	1655.5	98.77	49.4	Alzheimer's disease.	Henry W Querfurth, Frank M LaFerla	N Engl J Med	2010	20107219	No
1516	26470	1654.4	901.75	56.4	Fiji: an open-source platform for biological-image analysis.	Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert Cardona	Nat Methods	2012	22743772	Yes
1517	1653	1653.0	0.0	0.0	An improved procedure for serum creatine phosphokinase determination.	S B Rosalki	J Lab Clin Med	1967	4381359	Yes
1518	1653	1653.0	0.0	0.0	The recurrence of intracranial meningiomas after surgical treatment.	D Simpson	J Neurol Neurosurg Psychiatry	1957	13406590	Yes
1519	3306	1653.0	0.0	0.0	Convergent and discriminant validation by the multitrait-multimethod matrix.	D T Campbell, D W Fiske	Psychol Bull	1959	13634291	Yes
1520	1653	1653.0	39.99	40.0	Angiogenesis: an organizing principle for drug discovery?	Judah Folkman	Nat Rev Drug Discov	2007	17396134	No
1521	3304	1652.0	77.66	38.8	Shared principles in NF-kappaB signaling.	Matthew S Hayden, Sankar Ghosh	Cell	2008	18267068	No
1522	1652	1652.0	54.53	54.5	Matching methods for causal inference: A review and a look forward.	Elizabeth A Stuart	Stat Sci	2010	20871802	Yes
1523	3302	1651.0	128.0	64.0	The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger.	A J Stunkard, S Messick	J Psychosom Res	1985	3981480	Yes
1524	1651	1651.0	39.84	39.8	Inflammatory bowel disease: etiology and pathogenesis.	C Fiocchi	Gastroenterology	1998	9649475	No
1525	1651	1651.0	41.44	41.4	Integration, scaling, space-group assignment and post-refinement.	Wolfgang Kabsch	Acta Crystallogr D Biol Crystallogr	2010	20124693	Yes
1526	1650	1650.0	52.57	52.6	Metallothionein.	D H Hamer	Annu Rev Biochem	1986	3527054	No
1527	1650	1650.0	50.86	50.9	A measure of population subdivision based on microsatellite allele frequencies.	M Slatkin	Genetics	1995	7705646	Yes
1528	1650	1650.0	32.43	32.4	Hox genes in vertebrate development.	R Krumlauf	Cell	1994	7913880	No
1529	3299	1649.5	0.0	0.0	Method for the isolation of intact islets of Langerhans from the rat pancreas.	P E Lacy, M Kostianovsky	Diabetes	1967	5333500	Yes
1530	3299	1649.5	79.82	39.9	CAP3: A DNA sequence assembly program.	X Huang, A Madan	Genome Res	1999	10508846	Yes
1531	1647	1647.0	0.0	0.0	Paced auditory serial-addition task: a measure of recovery from concussion.	D M Gronwall	Percept Mot Skills	1977	866038	Yes
1532	1647	1647.0	40.55	40.5	Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods.	Z Yang	J Mol Evol	1994	7932792	Yes
1533	1647	1647.0	32.25	32.2	Cell cycle checkpoints: preventing an identity crisis.	S J Elledge	Science	1996	8939848	No
1534	1647	1647.0	32.25	32.2	Generating samples under a Wright-Fisher neutral model of genetic variation.	Richard R Hudson	Bioinformatics	2002	11847089	Yes
1535	3293	1646.5	107.16	53.6	Separate visual pathways for perception and action.	M A Goodale, A D Milner	Trends Neurosci	1992	1374953	No
1536	1645	1645.0	48.76	48.8	Classification of inflammatory bowel disease.	J E Lennard-Jones	Scand J Gastroenterol Suppl	1989	2617184	Yes
1537	1645	1645.0	0.0	0.0	A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma.	D Mattingly	J Clin Pathol	1962	14471419	Yes
1538	1644	1644.0	41.32	41.3	Cellular basis of working memory.	P S Goldman-Rakic	Neuron	1995	7695894	No
1539	3288	1644.0	0.0	0.0	The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties.	T Omura, R Sato	J Biol Chem	1964	14209972	Yes
1540	1643	1643.0	45.46	45.5	Turnover of inositol phospholipids and signal transduction.	Y Nishizuka	Science	1984	6147898	No
1541	1643	1643.0	41.96	42.0	Neurotrophins and neuronal plasticity.	H Thoenen	Science	1995	7570017	No
1542	4929	1643.0	107.54	35.8	Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.	J E Darnell, I M Kerr, G R Stark	Science	1994	8197455	No
1543	6572	1643.0	186.26	46.6	Comorbidity measures for use with administrative data.	A Elixhauser, C Steiner, D R Harris, R M Coffey	Med Care	1998	9431328	Yes
1544	1642	1642.0	40.28	40.3	Tricine-SDS-PAGE.	Hermann Schägger	Nat Protoc	2006	17406207	Yes
1545	3281	1640.5	117.54	58.8	The transtheoretical model of health behavior change.	J O Prochaska, W F Velicer	Am J Health Promot	1997	10170434	No
1546	1639	1639.0	50.67	50.7	Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance.	F Rousset	Genetics	1997	9093870	Yes
1547	8195	1639.0	207.29	41.5	Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.	Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan Hsu	N Engl J Med	2004	15385656	Yes
1548	4917	1639.0	109.39	36.5	An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database.	J K Eng, A L McCormack, J R Yates	J Am Soc Mass Spectrom	1994	24226387	Yes
1549	4916	1638.7	155.02	51.7	Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration.	Helga Thorvaldsdóttir, James T Robinson, Jill P Mesirov	Brief Bioinform	2013	22517427	Yes
1550	3274	1637.0	93.04	46.5	The precuneus: a review of its functional anatomy and behavioural correlates.	Andrea E Cavanna, Michael R Trimble	Brain	2006	16399806	No
1551	3273	1636.5	68.6	34.3	A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids.	D Wessel, U I Flügge	Anal Biochem	1984	6731838	Yes
1552	3273	1636.5	93.01	46.5	EQ-5D: a measure of health status from the EuroQol Group.	R Rabin, F de Charro	Ann Med	2001	11491192	No
1553	3273	1636.5	72.72	36.4	Fibroblasts in cancer.	Raghu Kalluri, Michael Zeisberg	Nat Rev Cancer	2006	16572188	No
1554	1636	1636.0	33.96	34.0	Oxidative stress shortens telomeres.	Thomas von Zglinicki	Trends Biochem Sci	2002	12114022	Yes
1555	1636	1636.0	43.73	43.7	THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons.	Kozi Asada	Annu Rev Plant Physiol Plant Mol Biol	1999	15012221	Yes
1556	3272	1636.0	71.88	35.9	The epigenomics of cancer.	Peter A Jones, Stephen B Baylin	Cell	2007	17320506	No
1557	3271	1635.5	71.37	35.7	Protein structure comparison by alignment of distance matrices.	L Holm, C Sander	J Mol Biol	1993	8377180	Yes
1558	6541	1635.2	262.51	65.6	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	Int J Surg	2010	20171303	No
1559	1635	1635.0	36.82	36.8	AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.	D Grahame Hardie	Nat Rev Mol Cell Biol	2007	17712357	No
1560	1633	1633.0	42.59	42.6	Alpha-crystallin can function as a molecular chaperone.	J Horwitz	Proc Natl Acad Sci U S A	1992	1438232	Yes
1561	1633	1633.0	46.59	46.6	The in vitro micronucleus technique.	M Fenech	Mutat Res	2000	11113469	No
1562	1632	1632.0	49.13	49.1	Extracellular ATP: effects, sources and fate.	J L Gordon	Biochem J	1986	3006665	No
1563	1632	1632.0	31.83	31.8	Network motifs: theory and experimental approaches.	Uri Alon	Nat Rev Genet	2007	17510665	No
1564	4892	1630.7	194.88	65.0	The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs.	C A McHorney, J E Ware, A E Raczek	Med Care	1993	8450681	Yes
1565	1630	1630.0	54.35	54.4	Number of people with glaucoma worldwide.	H A Quigley	Br J Ophthalmol	1996	8695555	No
1566	1629	1629.0	41.16	41.2	Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology.	B Winkel-Shirley	Plant Physiol	2001	11402179	No
1567	4884	1628.0	0.0	0.0	Impact of Event Scale: a measure of subjective stress.	M Horowitz, N Wilner, W Alvarez	Psychosom Med	1979	472086	Yes
1568	1628	1628.0	36.39	36.4	Trastuzumab--mechanism of action and use in clinical practice.	Clifford A Hudis	N Engl J Med	2007	17611206	No
1569	1627	1627.0	0.0	0.0	Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment.	K O Fagerström	Addict Behav	1978	735910	Yes
1570	4880	1626.7	577.58	192.5	An interactive web-based dashboard to track COVID-19 in real time.	Ensheng Dong, Hongru Du, Lauren Gardner	Lancet Infect Dis	2020	32087114	Yes
1571	1626	1626.0	58.29	58.3	Cell damage in the brain: a speculative synthesis.	B K Siesjö	J Cereb Blood Flow Metab	1981	6276420	No
1572	1626	1626.0	57.3	57.3	Falls in older people: epidemiology, risk factors and strategies for prevention.	Laurence Z Rubenstein	Age Ageing	2006	16926202	No
1573	6501	1625.2	227.31	56.8	SignalP 4.0: discriminating signal peptides from transmembrane regions.	Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik Nielsen	Nat Methods	2011	21959131	Yes
1574	1625	1625.0	31.15	31.1	Switching and signaling at the telomere.	E H Blackburn	Cell	2001	11572773	No
1575	8122	1624.4	185.55	37.1	Stages of embryonic development of the zebrafish.	C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F Schilling	Dev Dyn	1995	8589427	Yes
1576	1624	1624.0	70.7	70.7	Neurogenetic adaptive mechanisms in alcoholism.	C R Cloninger	Science	1987	2882604	Yes
1577	1624	1624.0	0.0	0.0	Structural considerations in the interaction of DNA and acridines.	L S Lerman	J Mol Biol	1961	13761054	Yes
1578	3248	1624.0	77.68	38.8	The BCL-2 protein family: opposing activities that mediate cell death.	Richard J Youle, Andreas Strasser	Nat Rev Mol Cell Biol	2008	18097445	No
1579	4867	1622.3	119.65	39.9	Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm.	Prateek Kumar, Steven Henikoff, Pauline C Ng	Nat Protoc	2009	19561590	Yes
1580	1622	1622.0	49.8	49.8	Constructions of masculinity and their influence on men's well-being: a theory of gender and health.	W H Courtenay	Soc Sci Med	2000	10741575	No
1581	1622	1622.0	0.0	0.0	Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study.	E G Gray	J Anat	1959	13829103	Yes
1582	1621	1621.0	34.92	34.9	Bone morphogenetic proteins: multifunctional regulators of vertebrate development.	B L Hogan	Genes Dev	1996	8682290	No
1583	1620	1620.0	50.93	50.9	Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage.	D W Choi	Trends Neurosci	1988	2469166	No
1584	1619	1619.0	72.65	72.7	Mood and memory.	G H Bower	Am Psychol	1981	7224324	Yes
1585	1619	1619.0	29.24	29.2	Maximum-likelihood density modification.	T C Terwilliger	Acta Crystallogr D Biol Crystallogr	2000	10944333	Yes
1586	3237	1618.5	76.02	38.0	The incidence of congenital heart disease.	Julien I E Hoffman, Samuel Kaplan	J Am Coll Cardiol	2002	12084585	No
1587	3235	1617.5	77.23	38.6	Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry.	Robert Visse, Hideaki Nagase	Circ Res	2003	12730128	No
1588	4851	1617.0	126.07	42.0	The rapid generation of mutation data matrices from protein sequences.	D T Jones, W R Taylor, J M Thornton	Comput Appl Biosci	1992	1633570	Yes
1589	3232	1616.0	77.29	38.6	Rapid and sensitive protein similarity searches.	D J Lipman, W R Pearson	Science	1985	2983426	Yes
1590	1615	1615.0	0.0	0.0	Synaptic density in human frontal cortex - developmental changes and effects of aging.	P R Huttenlocher	Brain Res	1979	427544	Yes
1591	3230	1615.0	0.0	0.0	The structure of coping.	L I Pearlin, C Schooler	J Health Soc Behav	1978	649936	Yes
1592	6460	1615.0	159.03	39.8	Improved optimization for the robust and accurate linear registration and motion correction of brain images.	Mark Jenkinson, Peter Bannister, Michael Brady, Stephen Smith	Neuroimage	2002	12377157	Yes
1593	3229	1614.5	109.5	54.8	Saliency, switching, attention and control: a network model of insula function.	Vinod Menon, Lucina Q Uddin	Brain Struct Funct	2010	20512370	No
1594	9685	1614.2	201.21	33.5	Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.	A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C Mello	Nature	1998	9486653	Yes
1595	1614	1614.0	0.0	0.0	Interhemispheric differences in the localization of psychological processes in man.	B Milner	Br Med Bull	1971	4937273	No
1596	1614	1614.0	0.0	0.0	The Gingival Index, the Plaque Index and the Retention Index Systems.	H Löe	J Periodontol	1967	5237684	Yes
1597	1613	1613.0	33.17	33.2	Structural features in eukaryotic mRNAs that modulate the initiation of translation.	M Kozak	J Biol Chem	1991	1939050	No
1598	1613	1613.0	34.5	34.5	The caveolae membrane system.	R G Anderson	Annu Rev Biochem	1998	9759488	No
1599	3223	1611.5	82.24	41.1	Macrophage diversity enhances tumor progression and metastasis.	Bin-Zhi Qian, Jeffrey W Pollard	Cell	2010	20371344	No
1600	1611	1611.0	47.26	47.3	Metalloproteinases and their inhibitors in matrix remodeling.	L M Matrisian	Trends Genet	1990	2132731	No
1601	1611	1611.0	34.71	34.7	Neuronal calcium signaling.	M J Berridge	Neuron	1998	9697848	No
1602	3221	1610.5	117.04	58.5	Pain assessment: global use of the Brief Pain Inventory.	C S Cleeland, K M Ryan	Ann Acad Med Singap	1994	8080219	No
1603	1610	1610.0	53.14	53.1	Archaea in coastal marine environments.	E F DeLong	Proc Natl Acad Sci U S A	1992	1608980	Yes
1604	1610	1610.0	36.9	36.9	Cellular oncogenes and retroviruses.	J M Bishop	Annu Rev Biochem	1983	6351725	No
1605	1610	1610.0	36.19	36.2	Perceptions of epigenetics.	Adrian Bird	Nature	2007	17522671	Yes
1606	1609	1609.0	30.34	30.3	Germinal centers.	I C MacLennan	Annu Rev Immunol	1994	8011279	No
1607	1609	1609.0	38.19	38.2	A revolution in optical manipulation.	David G Grier	Nature	2003	12917694	No
1608	3218	1609.0	86.47	43.2	Multiple sclerosis.	Alastair Compston, Alasdair Coles	Lancet	2008	18970977	Yes
1609	1608	1608.0	0.0	0.0	Fluorescence energy transfer as a spectroscopic ruler.	L Stryer	Annu Rev Biochem	1978	354506	No
1610	1608	1608.0	36.94	36.9	VLA proteins in the integrin family: structures, functions, and their role on leukocytes.	M E Hemler	Annu Rev Immunol	1990	2188667	No
1611	1607	1607.0	52.52	52.5	Validation of a decisional conflict scale.	A M O'Connor	Med Decis Making	1995	7898294	Yes
1612	1606	1606.0	56.36	56.4	Functional and effective connectivity: a review.	Karl J Friston	Brain Connect	2011	22432952	No
1613	1605	1605.0	55.93	55.9	Frontal-subcortical circuits and human behavior.	J L Cummings	Arch Neurol	1993	8352676	No
1614	1605	1605.0	42.39	42.4	Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp.	D A Dougherty	Science	1996	8539615	No
1615	1604	1604.0	0.0	0.0	Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.	B Hille	J Gen Physiol	1977	300786	Yes
1616	3208	1604.0	96.27	48.1	Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons.	M Karas, F Hillenkamp	Anal Chem	1988	3239801	Yes
1617	1604	1604.0	67.5	67.5	A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability.	D J Schuirmann	J Pharmacokinet Biopharm	1987	3450848	Yes
1618	3207	1603.5	63.02	31.5	Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene.	M E Greenberg, E B Ziff	Nature	1984	6090941	Yes
1619	1602	1602.0	39.62	39.6	Tumor necrosis factor (TNF).	L J Old	Science	1985	2413547	Yes
1620	8010	1602.0	0.0	0.0	Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function.	S Katz, A B Ford, R W Moskowitz, B A Jackson, M W Jaffe	JAMA	1963	14044222	Yes
1621	1602	1602.0	63.45	63.5	Cognitive reserve in ageing and Alzheimer's disease.	Yaakov Stern	Lancet Neurol	2012	23079557	No
1622	1601	1601.0	0.0	0.0	Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion.	O Ouchterlony	Acta Pathol Microbiol Scand	1953	13079779	Yes
1623	9601	1600.2	301.94	50.3	New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0.	Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier Gascuel	Syst Biol	2010	20525638	Yes
1624	3200	1600.0	113.36	56.7	Avoiding false positives with PCR.	S Kwok, R Higuchi	Nature	1989	2716852	Yes
1625	1600	1600.0	33.19	33.2	Neurotrophins and their receptors: a convergence point for many signalling pathways.	Moses V Chao	Nat Rev Neurosci	2003	12671646	No
1626	1600	1600.0	0.0	0.0	Impulses and Physiological States in Theoretical Models of Nerve Membrane.	R Fitzhugh	Biophys J	1961	19431309	Yes
1627	3199	1599.5	65.44	32.7	Upstream and downstream of mTOR.	Nissim Hay, Nahum Sonenberg	Genes Dev	2004	15314020	No
1628	9585	1597.5	224.45	37.4	Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.	D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuire	Science	1987	3798106	Yes
1629	3195	1597.5	62.32	31.2	Automated MAD and MIR structure solution.	T C Terwilliger, J Berendzen	Acta Crystallogr D Biol Crystallogr	1999	10089316	Yes
1630	1597	1597.0	31.75	31.8	An analysis of vertebrate mRNA sequences: intimations of translational control.	M Kozak	J Cell Biol	1991	1955461	No
1631	1597	1597.0	27.63	27.6	Cell cycle checkpoint signaling through the ATM and ATR kinases.	R T Abraham	Genes Dev	2001	11544175	No
1632	1597	1597.0	30.31	30.3	Neuroblastoma: biological insights into a clinical enigma.	Garrett M Brodeur	Nat Rev Cancer	2003	12612655	No
1633	3193	1596.5	111.1	55.5	The Oswestry Disability Index.	J C Fairbank, P B Pynsent	Spine (Phila Pa 1976)	2000	11074683	No
1634	1595	1595.0	45.63	45.6	Ionic dependence of glutamate neurotoxicity.	D W Choi	J Neurosci	1987	2880938	Yes
1635	1595	1595.0	0.0	0.0	The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept.	A G Pearse	J Histochem Cytochem	1969	4143745	No
1636	1595	1595.0	50.8	50.8	Cellular defenses against damage from reactive oxygen species.	B P Yu	Physiol Rev	1994	8295932	No
1637	3190	1595.0	74.48	37.2	Human mesenchymal stem cells modulate allogeneic immune cell responses.	Sudeepta Aggarwal, Mark F Pittenger	Blood	2005	15494428	Yes
1638	3188	1594.0	67.89	33.9	Inhibitors of mammalian G1 cyclin-dependent kinases.	C J Sherr, J M Roberts	Genes Dev	1995	7758941	No
1639	1594	1594.0	0.0	0.0	Discharge patterns and functional organization of mammalian retina.	S W Kuffler	J Neurophysiol	1953	13035466	Yes
1640	1593	1593.0	36.5	36.5	Introduction to NF-kappaB: players, pathways, perspectives.	T D Gilmore	Oncogene	2006	17072321	No
1641	3185	1592.5	65.36	32.7	Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases.	Gary L Johnson, Razvan Lapadat	Science	2002	12471242	No
1642	4777	1592.3	126.86	42.3	A neural substrate of prediction and reward.	W Schultz, P Dayan, P R Montague	Science	1997	9054347	No
1643	3183	1591.5	116.85	58.4	PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data.	Daniel R Roe, Thomas E Cheatham	J Chem Theory Comput	2013	26583988	Yes
1644	1591	1591.0	57.37	57.4	Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.	P Holzer	Pharmacol Rev	1991	1852779	No
1645	3180	1590.0	120.69	60.3	The mini-mental state examination: a comprehensive review.	T N Tombaugh, N J McIntyre	J Am Geriatr Soc	1992	1512391	No
1646	1590	1590.0	39.57	39.6	Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations.	M J Meaney	Annu Rev Neurosci	2001	11520931	No
1647	1590	1590.0	53.29	53.3	The polyvagal perspective.	Stephen W Porges	Biol Psychol	2007	17049418	No
1648	3177	1588.5	88.59	44.3	Polyamines.	C W Tabor, H Tabor	Annu Rev Biochem	1984	6206782	No
1649	1588	1588.0	40.87	40.9	Molecular biology of prion diseases.	S B Prusiner	Science	1991	1675487	No
1650	1588	1588.0	34.48	34.5	On finding all suboptimal foldings of an RNA molecule.	M Zuker	Science	1989	2468181	No
1651	9528	1588.0	330.12	55.0	Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.	L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R Tannenbaum	Anal Biochem	1982	7181105	Yes
1652	1587	1587.0	45.95	46.0	The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function.	R R Llinás	Science	1988	3059497	No
1653	4761	1587.0	159.02	53.0	A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study.	J R Le Gall, S Lemeshow, F Saulnier	JAMA	1993	8254858	Yes
1654	6347	1586.8	184.17	46.0	Functional connectivity in the motor cortex of resting human brain using echo-planar MRI.	B Biswal, F Z Yetkin, V M Haughton, J S Hyde	Magn Reson Med	1995	8524021	Yes
1655	3173	1586.5	78.34	39.2	A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes.	S Tabor, C C Richardson	Proc Natl Acad Sci U S A	1985	3156376	Yes
1656	4759	1586.3	133.25	44.4	Cell death: the significance of apoptosis.	A H Wyllie, J F Kerr, A R Currie	Int Rev Cytol	1980	7014501	No
1657	1586	1586.0	58.04	58.0	The linear-quadratic formula and progress in fractionated radiotherapy.	J F Fowler	Br J Radiol	1989	2670032	No
1658	1584	1584.0	61.35	61.4	Probiotics in man and animals.	R Fuller	J Appl Bacteriol	1989	2666378	No
1659	1584	1584.0	32.78	32.8	DNA in a material world.	Nadrian C Seeman	Nature	2003	12540916	No
1660	1584	1584.0	35.17	35.2	The NCI60 human tumour cell line anticancer drug screen.	Robert H Shoemaker	Nat Rev Cancer	2006	16990858	No
1661	1583	1583.0	45.63	45.6	The basal ganglia: focused selection and inhibition of competing motor programs.	J W Mink	Prog Neurobiol	1996	9004351	No
1662	3165	1582.5	93.4	46.7	An information-maximization approach to blind separation and blind deconvolution.	A J Bell, T J Sejnowski	Neural Comput	1995	7584893	Yes
1663	3164	1582.0	97.68	48.8	Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.	D S Bredt, S H Snyder	Proc Natl Acad Sci U S A	1990	1689048	Yes
1664	1582	1582.0	36.8	36.8	PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms.	Michael F. Thomashow	Annu Rev Plant Physiol Plant Mol Biol	1999	15012220	Yes
1665	1581	1581.0	35.72	35.7	The proto-oncogene Bcl-2 and its role in regulating apoptosis.	G Kroemer	Nat Med	1997	9176486	No
1666	1581	1581.0	39.53	39.5	Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia.	Shitij Kapur	Am J Psychiatry	2003	12505794	No
1667	3161	1580.5	116.4	58.2	The need to belong: desire for interpersonal attachments as a fundamental human motivation.	R F Baumeister, M R Leary	Psychol Bull	1995	7777651	No
1668	1580	1580.0	0.0	0.0	Simple memory: a theory for archicortex.	D Marr	Philos Trans R Soc Lond B Biol Sci	1971	4399412	Yes
1669	1579	1579.0	0.0	0.0	Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection.	W H Oldendorf	Am J Physiol	1971	5124307	Yes
1670	3158	1579.0	96.23	48.1	Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC).	Kathryn M Connor, Jonathan R T Davidson	Depress Anxiety	2003	12964174	Yes
1671	3154	1577.0	91.61	45.8	Oxidative stress, glutamate, and neurodegenerative disorders.	J T Coyle, P Puttfarcken	Science	1993	7901908	No
1672	1577	1577.0	45.73	45.7	Semiempirical hybrid density functional with perturbative second-order correlation.	Stefan Grimme	J Chem Phys	2006	16438568	Yes
1673	6302	1575.5	252.09	63.0	16S ribosomal DNA amplification for phylogenetic study.	W G Weisburg, S M Barns, D A Pelletier, D J Lane	J Bacteriol	1991	1987160	Yes
1674	3151	1575.5	66.13	33.1	Signaling to NF-kappaB.	Matthew S Hayden, Sankar Ghosh	Genes Dev	2004	15371334	No
1675	7877	1575.4	314.55	62.9	UCHIME improves sensitivity and speed of chimera detection.	Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob Knight	Bioinformatics	2011	21700674	Yes
1676	1575	1575.0	0.0	0.0	Regulation of noradrenaline release by presynaptic receptor systems.	K Starke	Rev Physiol Biochem Pharmacol	1977	14389	No
1677	1575	1575.0	70.71	70.7	The contribution of low birth weight to infant mortality and childhood morbidity.	M C McCormick	N Engl J Med	1985	3880598	No
1678	1575	1575.0	0.0	0.0	Amino acid difference formula to help explain protein evolution.	R Grantham	Science	1974	4843792	Yes
1679	1575	1575.0	57.71	57.7	Aging, natural death, and the compression of morbidity.	J F Fries	N Engl J Med	1980	7383070	Yes
1680	1575	1575.0	51.94	51.9	Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances.	Joseph J Volpe	Lancet Neurol	2009	19081519	No
1681	1574	1574.0	38.56	38.6	Recognition of errors in three-dimensional structures of proteins.	M J Sippl	Proteins	1993	8108378	Yes
1682	3148	1574.0	106.62	53.3	Genome editing. The new frontier of genome engineering with CRISPR-Cas9.	Jennifer A Doudna, Emmanuelle Charpentier	Science	2014	25430774	No
1683	1573	1573.0	52.4	52.4	Biology of interleukin 1.	C A Dinarello	FASEB J	1988	3277884	No
1684	1573	1573.0	36.26	36.3	Thiazolidinediones.	Hannele Yki-Järvinen	N Engl J Med	2004	15356308	No
1685	4716	1572.0	93.33	31.1	T-Coffee: A novel method for fast and accurate multiple sequence alignment.	C Notredame, D G Higgins, J Heringa	J Mol Biol	2000	10964570	Yes
1686	1571	1571.0	28.57	28.6	Altering the genome by homologous recombination.	M R Capecchi	Science	1989	2660260	No
1687	1571	1571.0	36.41	36.4	Getting formal with dopamine and reward.	Wolfram Schultz	Neuron	2002	12383780	No
1688	3142	1571.0	76.0	38.0	Adipose tissue as an endocrine organ.	Erin E Kershaw, Jeffrey S Flier	J Clin Endocrinol Metab	2004	15181022	No
1689	3141	1570.5	127.35	63.7	Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use.	A Y Finlay, G K Khan	Clin Exp Dermatol	1994	8033378	Yes
1690	1570	1570.0	38.03	38.0	HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy.	J M Coffin	Science	1995	7824947	Yes
1691	3140	1570.0	94.17	47.1	Unified approach for molecular dynamics and density-functional theory.	Car, Parrinello	Phys Rev Lett	1985	10032153	Yes
1692	1570	1570.0	29.53	29.5	How cells read TGF-beta signals.	J Massagué	Nat Rev Mol Cell Biol	2000	11252892	No
1693	6279	1569.8	183.06	45.8	The validity of the Hospital Anxiety and Depression Scale. An updated literature review.	Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag Neckelmann	J Psychosom Res	2002	11832252	No
1694	4708	1569.3	116.34	38.8	Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey.	Earl S Ford, Wayne H Giles, William H Dietz	JAMA	2002	11790215	Yes
1695	1569	1569.0	56.56	56.6	Dual-task interference in simple tasks: data and theory.	H Pashler	Psychol Bull	1994	7972591	No
1696	1569	1569.0	30.79	30.8	The microRNA Registry.	Sam Griffiths-Jones	Nucleic Acids Res	2004	14681370	Yes
1697	1568	1568.0	44.91	44.9	Glycosphingolipids in cellular interaction, differentiation, and oncogenesis.	S Hakomori	Annu Rev Biochem	1981	7023369	No
1698	3135	1567.5	0.0	0.0	Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration.	D B Dill, D L Costill	J Appl Physiol	1974	4850854	Yes
1699	1567	1567.0	51.58	51.6	Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue').	M N Marsh	Gastroenterology	1992	1727768	No
1700	1567	1567.0	41.64	41.6	Molecular bases of the acute coronary syndromes.	P Libby	Circulation	1995	7758192	No
1701	1567	1567.0	42.73	42.7	The complete general secretory pathway in gram-negative bacteria.	A P Pugsley	Microbiol Rev	1993	8096622	No
1702	1566	1566.0	0.0	0.0	The estimation of phosphorus.	R J Allen	Biochem J	1940	16747230	Yes
1703	3131	1565.5	206.1	103.0	A clinical method of functional assessment of the shoulder.	C R Constant, A H Murley	Clin Orthop Relat Res	1987	3791738	Yes
1704	3131	1565.5	104.98	52.5	Neurocircuitry of addiction.	George F Koob, Nora D Volkow	Neuropsychopharmacology	2010	19710631	No
1705	1565	1565.0	71.38	71.4	Measurement of health state utilities for economic appraisal.	G W Torrance	J Health Econ	1986	10311607	No
1706	1564	1564.0	34.34	34.3	An approximately unbiased test of phylogenetic tree selection.	Hidetoshi Shimodaira	Syst Biol	2002	12079646	Yes
1707	1564	1564.0	0.0	0.0	Application of a Theory of Enzyme Specificity to Protein Synthesis.	D E Koshland	Proc Natl Acad Sci U S A	1958	16590179	Yes
1708	1562	1562.0	45.38	45.4	Gold-catalyzed organic reactions.	A Stephen K Hashmi	Chem Rev	2007	17580975	Yes
1709	1561	1561.0	60.2	60.2	Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides.	P Holzer	Neuroscience	1988	3288903	No
1710	1561	1561.0	0.0	0.0	Dithiothreitol, A New Protective Reagent For Sh Groups.	W W Cleland	Biochemistry	1964	14192894	Yes
1711	1561	1561.0	0.0	0.0	A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin.	B C Hummel	Can J Biochem Physiol	1959	14405350	Yes
1712	1561	1561.0	0.0	0.0	Note on the sampling error of the difference between correlated proportions or percentages.	Q McNEMAR	Psychometrika	1947	20254758	Yes
1713	1560	1560.0	0.0	0.0	Which elements are excited in electrical stimulation of mammalian central nervous system: a review.	J B Ranck	Brain Res	1975	1102064	No
1714	1560	1560.0	45.95	46.0	The many roles for fluorine in medicinal chemistry.	William K Hagmann	J Med Chem	2008	18570365	Yes
1715	1559	1559.0	45.9	45.9	Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements.	James J P Stewart	J Mol Model	2007	17828561	Yes
1716	4677	1559.0	211.92	70.6	Scoping studies: advancing the methodology.	Danielle Levac, Heather Colquhoun, Kelly K O'Brien	Implement Sci	2010	20854677	Yes
1717	1559	1559.0	104.11	104.1	Understanding Bland Altman analysis.	Davide Giavarina	Biochem Med (Zagreb)	2015	26110027	No
1718	6234	1558.5	0.0	0.0	The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care.	S P Baker, B O'Neill, W Haddon, W B Long	J Trauma	1974	4814394	Yes
1719	1558	1558.0	35.53	35.5	Hypertrophic cardiomyopathy: a systematic review.	Barry J Maron	JAMA	2002	11886323	No
1720	1558	1558.0	37.05	37.0	In vivo near-infrared fluorescence imaging.	John V Frangioni	Curr Opin Chem Biol	2003	14580568	No
1721	1558	1558.0	38.16	38.2	The failing heart--an engine out of fuel.	Stefan Neubauer	N Engl J Med	2007	17360992	No
1722	1557	1557.0	64.45	64.5	Adverse health effects of high-effort/low-reward conditions.	J Siegrist	J Occup Health Psychol	1996	9547031	No
1723	6224	1556.0	0.0	0.0	A rating scale for mania: reliability, validity and sensitivity.	R C Young, J T Biggs, V E Ziegler, D A Meyer	Br J Psychiatry	1978	728692	Yes
1724	1556	1556.0	34.09	34.1	Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1.	G L Semenza	Annu Rev Cell Dev Biol	1999	10611972	No
1725	1556	1556.0	38.64	38.6	The corticosteroid receptor hypothesis of depression.	F Holsboer	Neuropsychopharmacology	2000	11027914	No
1726	1556	1556.0	0.0	0.0	Cerebral blood flow and oxygen consumption in man.	N A Lassen	Physiol Rev	1959	13645234	Yes
1727	3111	1555.5	130.67	65.3	ROS function in redox signaling and oxidative stress.	Michael Schieber, Navdeep S Chandel	Curr Biol	2014	24845678	No
1728	1555	1555.0	48.31	48.3	The role of the amygdala in fear and anxiety.	M Davis	Annu Rev Neurosci	1992	1575447	No
1729	6218	1554.5	264.87	66.2	An inventory for measuring clinical anxiety: psychometric properties.	A T Beck, N Epstein, G Brown, R A Steer	J Consult Clin Psychol	1988	3204199	Yes
1730	1554	1554.0	36.15	36.1	A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin.	D A Gewirtz	Biochem Pharmacol	1999	10075079	No
1731	3106	1553.0	98.35	49.2	The pathogenesis of rheumatoid arthritis.	Iain B McInnes, Georg Schett	N Engl J Med	2011	22150039	No
1732	3105	1552.5	60.77	30.4	Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.	O Tetsu, F McCormick	Nature	1999	10201372	Yes
1733	1551	1551.0	55.7	55.7	The case-crossover design: a method for studying transient effects on the risk of acute events.	M Maclure	Am J Epidemiol	1991	1985444	Yes
1734	1551	1551.0	49.37	49.4	Aging, cellular senescence, and cancer.	Judith Campisi	Annu Rev Physiol	2013	23140366	No
1735	4652	1550.7	103.63	34.5	Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.	M A Frohman, M K Dush, G R Martin	Proc Natl Acad Sci U S A	1988	2461560	Yes
1736	4651	1550.3	0.0	0.0	A highly sensitive adenylate cyclase assay.	Y Salomon, C Londos, M Rodbell	Anal Biochem	1974	4827395	Yes
1737	1550	1550.0	0.0	0.0	Statistical analysis of enzyme kinetic data.	W W Cleland	Methods Enzymol	1979	502857	Yes
1738	1550	1550.0	70.35	70.3	The structure and properties of the sense of coherence scale.	A Antonovsky	Soc Sci Med	1993	8480217	Yes
1739	3100	1550.0	89.99	45.0	Protective and pathogenic functions of macrophage subsets.	Peter J Murray, Thomas A Wynn	Nat Rev Immunol	2011	21997792	No
1740	3099	1549.5	102.47	51.2	The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today.	R Doll, R Peto	J Natl Cancer Inst	1981	7017215	No
1741	1549	1549.0	41.11	41.1	Precision mapping of quantitative trait loci.	Z B Zeng	Genetics	1994	8013918	Yes
1742	3098	1549.0	82.25	41.1	Early identification of refractory epilepsy.	P Kwan, M J Brodie	N Engl J Med	2000	10660394	Yes
1743	1549	1549.0	34.56	34.6	Hematopoietic stem-cell transplantation.	Edward A Copelan	N Engl J Med	2006	16641398	No
1744	3092	1546.0	102.2	51.1	Palladium-catalyzed ligand-directed C-H functionalization reactions.	Thomas W Lyons, Melanie S Sanford	Chem Rev	2010	20078038	No
1745	1545	1545.0	63.75	63.8	Responses to depression and their effects on the duration of depressive episodes.	S Nolen-Hoeksema	J Abnorm Psychol	1991	1757671	No
1746	1545	1545.0	69.96	70.0	Optical properties of biological tissues: a review.	Steven L Jacques	Phys Med Biol	2013	23666068	No
1747	1544	1544.0	34.38	34.4	Gene finding in novel genomes.	Ian Korf	BMC Bioinformatics	2004	15144565	Yes
1748	3087	1543.5	0.0	0.0	Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome.	C B Lozzio, B B Lozzio	Blood	1975	163658	Yes
1749	1542	1542.0	43.26	43.3	Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat.	P A Bradford	Clin Microbiol Rev	2001	11585791	No
1750	1542	1542.0	36.28	36.3	Neurovascular regulation in the normal brain and in Alzheimer's disease.	Costantino Iadecola	Nat Rev Neurosci	2004	15100718	No
1751	3083	1541.5	61.92	31.0	NF-kappaB regulation in the immune system.	Qiutang Li, Inder M Verma	Nat Rev Immunol	2002	12360211	No
1752	3078	1539.0	0.0	0.0	Computed circular dichroism spectra for the evaluation of protein conformation.	N Greenfield, G D Fasman	Biochemistry	1969	5346390	Yes
1753	1539	1539.0	31.27	31.3	The ubiquitin-proteasome proteolytic pathway.	A Ciechanover	Cell	1994	7923371	No
1754	1539	1539.0	39.98	40.0	External validity of randomised controlled trials: "to whom do the results of this trial apply?".	Peter M Rothwell	Lancet	2005	15639683	Yes
1755	1538	1538.0	30.52	30.5	E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.	J R Nevins	Science	1992	1411535	Yes
1756	1538	1538.0	42.33	42.3	Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum.	A Fabiato	Am J Physiol	1983	6346892	No
1757	1538	1538.0	36.95	37.0	Two pathogenetic types of endometrial carcinoma.	J V Bokhman	Gynecol Oncol	1983	6822361	Yes
1758	1538	1538.0	33.15	33.1	Maintenance of C. elegans.	Theresa Stiernagle	WormBook	2006	18050451	No
1759	3075	1537.5	114.52	57.3	The integrative review: updated methodology.	Robin Whittemore, Kathleen Knafl	J Adv Nurs	2005	16268861	Yes
1760	1537	1537.0	0.0	0.0	Bias in analytic research.	D L Sackett	J Chronic Dis	1979	447779	Yes
1761	1537	1537.0	30.65	30.6	Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing.	D I Svergun	Biophys J	1999	10354416	Yes
1762	3074	1537.0	0.0	0.0	A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues.	G Schmidt, S J Thannhauser	J Biol Chem	1945	21005717	Yes
1763	3072	1536.0	0.0	0.0	New Giemsa method for the differential staining of sister chromatids.	P Perry, S Wolff	Nature	1974	4138930	Yes
1764	1536	1536.0	28.97	29.0	Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy.	M G Gustafsson	J Microsc	2000	10810003	Yes
1765	1535	1535.0	29.53	29.5	Intrinsically unstructured proteins.	Peter Tompa	Trends Biochem Sci	2002	12368089	No
1766	4603	1534.3	126.66	42.2	Dating of the human-ape splitting by a molecular clock of mitochondrial DNA.	M Hasegawa, H Kishino, T Yano	J Mol Evol	1985	3934395	Yes
1767	4602	1534.0	92.0	30.7	Efficient selection for high-expression transfectants with a novel eukaryotic vector.	H Niwa, K Yamamura, J Miyazaki	Gene	1991	1660837	Yes
1768	1534	1534.0	44.26	44.3	Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.	A E Pegg	Cancer Res	1988	3123052	No
1769	1534	1534.0	0.0	0.0	Antigen-Antibody Crossed Electrophoresis.	C B Laurell	Anal Biochem	1965	14302464	Yes
1770	1533	1533.0	38.95	39.0	Early signals in the mitogenic response.	E Rozengurt	Science	1986	3018928	No
1771	1533	1533.0	62.09	62.1	Sample size in qualitative research.	M Sandelowski	Res Nurs Health	1995	7899572	Yes
1772	3065	1532.5	90.53	45.3	Astrocytes: biology and pathology.	Michael V Sofroniew, Harry V Vinters	Acta Neuropathol	2010	20012068	No
1773	1532	1532.0	34.11	34.1	Molecular themes in oncogenesis.	J M Bishop	Cell	1991	1988146	No
1774	3064	1532.0	62.96	31.5	A guided tour into subcellular colocalization analysis in light microscopy.	S Bolte, F P Cordelières	J Microsc	2006	17210054	Yes
1775	3063	1531.5	85.45	42.7	Diarrheagenic Escherichia coli.	J P Nataro, J B Kaper	Clin Microbiol Rev	1998	9457432	No
1776	1530	1530.0	0.0	0.0	An enzymic method for the trace iodination of immunoglobulins and other proteins.	J J Marchalonis	Biochem J	1969	4185494	Yes
1777	4590	1530.0	86.7	28.9	Notch signaling: cell fate control and signal integration in development.	S Artavanis-Tsakonas, M D Rand, R J Lake	Science	1999	10221902	No
1778	1530	1530.0	30.96	31.0	Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy.	R K Jain	Nat Med	2001	11533692	No
1779	1529	1529.0	36.95	37.0	Five rules for the evolution of cooperation.	Martin A Nowak	Science	2006	17158317	No
1780	1528	1528.0	0.0	0.0	Calcium release from the sarcoplasmic reticulum.	M Endo	Physiol Rev	1977	13441	Yes
1781	1528	1528.0	0.0	0.0	Biological applications of ionophores.	B C Pressman	Annu Rev Biochem	1976	786156	No
1782	1528	1528.0	34.23	34.2	Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.	C Taswell	J Immunol	1981	7009746	Yes
1783	1528	1528.0	30.57	30.6	Regulatory T cells, tumour immunity and immunotherapy.	Weiping Zou	Nat Rev Immunol	2006	16557261	No
1784	1528	1528.0	65.72	65.7	Whatever next? Predictive brains, situated agents, and the future of cognitive science.	Andy Clark	Behav Brain Sci	2013	23663408	No
1785	1527	1527.0	42.69	42.7	Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy.	Y Ben-Ari	Neuroscience	1985	2859548	No
1786	1527	1527.0	45.39	45.4	Recent advances in the biochemistry of polyamines in eukaryotes.	A E Pegg	Biochem J	1986	3087344	No
1787	1527	1527.0	25.76	25.8	Neuronal specification in the spinal cord: inductive signals and transcriptional codes.	T M Jessell	Nat Rev Genet	2000	11262869	No
1788	1527	1527.0	41.52	41.5	Synergy, antagonism, and what the chequerboard puts between them.	F C Odds	J Antimicrob Chemother	2003	12805255	No
1789	1527	1527.0	51.39	51.4	The global impact of pre-eclampsia and eclampsia.	Lelia Duley	Semin Perinatol	2009	19464502	No
1790	1527	1527.0	62.31	62.3	Selenium and human health.	Margaret P Rayman	Lancet	2012	22381456	No
1791	3053	1526.5	67.09	33.5	Complex networks orchestrate epithelial-mesenchymal transitions.	Jean Paul Thiery, Jonathan P Sleeman	Nat Rev Mol Cell Biol	2006	16493418	No
1792	3052	1526.0	57.22	28.6	The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.	Michael H Glickman, Aaron Ciechanover	Physiol Rev	2002	11917093	No
1793	1526	1526.0	47.97	48.0	Stress signalling pathways that impair prefrontal cortex structure and function.	Amy F T Arnsten	Nat Rev Neurosci	2009	19455173	No
1794	3049	1524.5	0.0	0.0	The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat.	J O'Keefe, J Dostrovsky	Brain Res	1971	5124915	Yes
1795	1524	1524.0	35.28	35.3	Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis.	S C Manolagas	Endocr Rev	2000	10782361	No
1796	3045	1522.5	64.53	32.3	The Ki-67 protein: from the known and the unknown.	T Scholzen, J Gerdes	J Cell Physiol	2000	10653597	No
1797	1522	1522.0	33.79	33.8	Mechanisms of bone metastasis.	G David Roodman	N Engl J Med	2004	15084698	No
1798	1521	1521.0	41.41	41.4	Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.	L A Liotta	Cancer Res	1986	2998604	No
1799	1521	1521.0	0.0	0.0	Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report.	C S Neer	J Bone Joint Surg Am	1972	5054450	Yes
1800	1521	1521.0	0.0	0.0	Some observations upon a new inhibitor of monoamine oxidase in brain tissue.	J P Johnston	Biochem Pharmacol	1968	5659776	Yes
1801	1521	1521.0	37.29	37.3	The biology of incretin hormones.	Daniel J Drucker	Cell Metab	2006	16517403	No
1802	3041	1520.5	97.46	48.7	Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics.	G R Gibson, M B Roberfroid	J Nutr	1995	7782892	No
1803	1520	1520.0	32.21	32.2	Drug discovery: a historical perspective.	J Drews	Science	2000	10720314	No
1804	3040	1520.0	0.0	0.0	Junctional complexes in various epithelia.	M G Farquhar, G E Palade	J Cell Biol	1963	13944428	Yes
1805	3040	1520.0	86.58	43.3	Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research.	Sally S Dickerson, Margaret E Kemeny	Psychol Bull	2004	15122924	Yes
1806	3039	1519.5	83.91	42.0	Molecular mechanisms of long noncoding RNAs.	Kevin C Wang, Howard Y Chang	Mol Cell	2011	21925379	No
1807	3039	1519.5	144.33	72.2	mTOR Signaling in Growth, Metabolism, and Disease.	Robert A Saxton, David M Sabatini	Cell	2017	28283069	No
1808	1519	1519.0	29.39	29.4	Protein degradation and protection against misfolded or damaged proteins.	Alfred L Goldberg	Nature	2003	14685250	No
1809	3038	1519.0	63.79	31.9	Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions.	E Krissinel, K Henrick	Acta Crystallogr D Biol Crystallogr	2004	15572779	Yes
1810	3038	1519.0	92.21	46.1	Density functionals with broad applicability in chemistry.	Yan Zhao, Donald G Truhlar	Acc Chem Res	2008	18186612	Yes
1811	1518	1518.0	0.0	0.0	Selforganization of matter and the evolution of biological macromolecules.	M Eigen	Naturwissenschaften	1971	4942363	No
1812	1518	1518.0	31.29	31.3	The lasso method for variable selection in the Cox model.	R Tibshirani	Stat Med	1997	9044528	Yes
1813	4552	1517.3	112.25	37.4	Two-photon laser scanning fluorescence microscopy.	W Denk, J H Strickler, W W Webb	Science	1990	2321027	Yes
1814	1517	1517.0	0.0	0.0	Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase.	H S Penefsky	J Biol Chem	1977	16006	Yes
1815	1517	1517.0	47.66	47.7	Evidence for a central component of post-injury pain hypersensitivity.	C J Woolf	Nature	1983	6656869	Yes
1816	3033	1516.5	88.41	44.2	A perspective on cancer cell metastasis.	Christine L Chaffer, Robert A Weinberg	Science	2011	21436443	No
1817	1516	1516.0	40.15	40.1	Task switching.	Stephen Monsell	Trends Cogn Sci	2003	12639695	Yes
1818	1516	1516.0	29.68	29.7	Immunosuppressive networks in the tumour environment and their therapeutic relevance.	Weiping Zou	Nat Rev Cancer	2005	15776005	No
1819	1516	1516.0	36.34	36.3	Insulin and insulin-like growth factor signalling in neoplasia.	Michael Pollak	Nat Rev Cancer	2008	19029956	No
1820	3031	1515.5	66.87	33.4	Neurotrophins: roles in neuronal development and function.	E J Huang, L F Reichardt	Annu Rev Neurosci	2001	11520916	No
1821	1515	1515.0	38.13	38.1	Trophic factors and neuronal survival.	Y A Barde	Neuron	1989	2697237	No
1822	4543	1514.3	109.98	36.7	Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets.	Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck Ørntoft	Cancer Res	2004	15289330	Yes
1823	1514	1514.0	47.58	47.6	Efficient analysis of experimental observations.	W J Dixon	Annu Rev Pharmacol Toxicol	1980	7387124	Yes
1824	1514	1514.0	54.19	54.2	Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement.	Virginia A Moyer	Ann Intern Med	2012	22801674	No
1825	15133	1513.3	365.51	36.6	Multilineage potential of adult human mesenchymal stem cells.	M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R Marshak	Science	1999	10102814	Yes
1826	1513	1513.0	32.62	32.6	From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.	W A Catterall	Neuron	2000	10798388	No
1827	3025	1512.5	69.22	34.6	The human plasma proteome: history, character, and diagnostic prospects.	N Leigh Anderson, Norman G Anderson	Mol Cell Proteomics	2002	12488461	No
1828	1512	1512.0	42.82	42.8	The origins of the developmental origins theory.	D J P Barker	J Intern Med	2007	17444880	No
1829	1512	1512.0	48.52	48.5	Stress and disorders of the stress system.	George P Chrousos	Nat Rev Endocrinol	2009	19488073	No
1830	3023	1511.5	57.33	28.7	Mutations affecting segment number and polarity in Drosophila.	C Nüsslein-Volhard, E Wieschaus	Nature	1980	6776413	Yes
1831	4534	1511.3	152.84	50.9	Phylogenetic identification and in situ detection of individual microbial cells without cultivation.	R I Amann, W Ludwig, K H Schleifer	Microbiol Rev	1995	7535888	No
1832	1510	1510.0	0.0	0.0	A soluble protein characteristic of the nervous system.	B W Moore	Biochem Biophys Res Commun	1965	4953930	Yes
1833	1510	1510.0	46.07	46.1	Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance.	L Bravo	Nutr Rev	1998	9838798	No
1834	3019	1509.5	80.25	40.1	Dali server: conservation mapping in 3D.	Liisa Holm, Päivi Rosenström	Nucleic Acids Res	2010	20457744	Yes
1835	1509	1509.0	0.0	0.0	Dopamine (3-hydroxytyramine) and brain function.	O Hornykiewicz	Pharmacol Rev	1966	5328389	No
1836	3018	1509.0	68.46	34.2	Lipopolysaccharide endotoxins.	Christian R H Raetz, Chris Whitfield	Annu Rev Biochem	2002	12045108	No
1837	1509	1509.0	38.83	38.8	The importance of the ratio of omega-6/omega-3 essential fatty acids.	A P Simopoulos	Biomed Pharmacother	2002	12442909	No
1838	3018	1509.0	61.56	30.8	Toll-like receptor control of the adaptive immune responses.	Akiko Iwasaki, Ruslan Medzhitov	Nat Immunol	2004	15454922	No
1839	3016	1508.0	66.94	33.5	Cell migration: a physically integrated molecular process.	D A Lauffenburger, A F Horwitz	Cell	1996	8608589	No
1840	4523	1507.7	117.6	39.2	Optimization by simulated annealing.	S Kirkpatrick, C D Gelatt, M P Vecchi	Science	1983	17813860	Yes
1841	3015	1507.5	81.83	40.9	Regulation of chromatin by histone modifications.	Andrew J Bannister, Tony Kouzarides	Cell Res	2011	21321607	No
1842	4521	1507.0	96.13	32.0	The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.	S K Hanks, A M Quinn, T Hunter	Science	1988	3291115	No
1843	1507	1507.0	35.1	35.1	Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study).	K M Fox	Lancet	2003	13678872	Yes
1844	1506	1506.0	38.57	38.6	Hydrogels for biomedical applications.	Allan S Hoffman	Adv Drug Deliv Rev	2002	11755703	No
1845	1506	1506.0	39.46	39.5	Understanding biofilm resistance to antibacterial agents.	David Davies	Nat Rev Drug Discov	2003	12563302	No
1846	1505	1505.0	48.45	48.5	Health consequences of obesity in youth: childhood predictors of adult disease.	W H Dietz	Pediatrics	1998	12224658	No
1847	3010	1505.0	66.64	33.3	Microtubules as a target for anticancer drugs.	Mary Ann Jordan, Leslie Wilson	Nat Rev Cancer	2004	15057285	No
1848	3009	1504.5	0.0	0.0	Diabetes and cardiovascular disease. The Framingham study.	W B Kannel, D L McGee	JAMA	1979	430798	Yes
1849	1504	1504.0	0.0	0.0	Nutrition needs of mammalian cells in tissue culture.	H Eagle	Science	1955	13255879	Yes
1850	3007	1503.5	62.79	31.4	Fitting a mixture model by expectation maximization to discover motifs in biopolymers.	T L Bailey, C Elkan	Proc Int Conf Intell Syst Mol Biol	1994	7584402	Yes
1851	1503	1503.0	47.83	47.8	The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate.	G R Buettner	Arch Biochem Biophys	1993	8434935	No
1852	3006	1503.0	61.7	30.9	The Bcl2 family: regulators of the cellular life-or-death switch.	Suzanne Cory, Jerry M Adams	Nat Rev Cancer	2002	12209154	No
1853	1502	1502.0	37.87	37.9	Type I diabetes mellitus. A chronic autoimmune disease.	G S Eisenbarth	N Engl J Med	1986	3517648	No
1854	1502	1502.0	35.85	35.9	The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting.	H Maeda	Adv Enzyme Regul	2001	11384745	No
1855	1502	1502.0	46.48	46.5	Domino Reactions in Organic Synthesis.	Lutz F. Tietze	Chem Rev	1996	11848746	Yes
1856	3004	1502.0	60.53	30.3	An automated method for finding molecular complexes in large protein interaction networks.	Gary D Bader, Christopher W V Hogue	BMC Bioinformatics	2003	12525261	Yes
1857	3004	1502.0	92.38	46.2	The benefits of being present: mindfulness and its role in psychological well-being.	Kirk Warren Brown, Richard M Ryan	J Pers Soc Psychol	2003	12703651	Yes
1858	6004	1501.0	119.89	30.0	A comparison of normalization methods for high density oligonucleotide array data based on variance and bias.	B M Bolstad, R A Irizarry, M Astrand, T P Speed	Bioinformatics	2003	12538238	Yes
1859	1501	1501.0	51.34	51.3	Asthma phenotypes: the evolution from clinical to molecular approaches.	Sally E Wenzel	Nat Med	2012	22561835	No
1860	3001	1500.5	107.09	53.5	Measuring emotion: the Self-Assessment Manikin and the Semantic Differential.	M M Bradley, P J Lang	J Behav Ther Exp Psychiatry	1994	7962581	Yes
1861	1500	1500.0	0.0	0.0	Atherogenesis: a postprandial phenomenon.	D B Zilversmit	Circulation	1979	222498	Yes
1862	2999	1499.5	73.88	36.9	Malignant gliomas in adults.	Patrick Y Wen, Santosh Kesari	N Engl J Med	2008	18669428	No
1863	1498	1498.0	0.0	0.0	Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.	J C Unkeless	J Exp Med	1979	90108	Yes
1864	2995	1497.5	59.42	29.7	Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins.	P J Mitchell, R Tjian	Science	1989	2667136	No
1865	2994	1497.0	73.95	37.0	Steatohepatitis: a tale of two "hits"?	C P Day, O F James	Gastroenterology	1998	9547102	No
1866	1495	1495.0	51.69	51.7	Lyme disease.	A C Steere	N Engl J Med	1989	2668764	No
1867	1495	1495.0	34.32	34.3	Pathogenesis of group A streptococcal infections.	M W Cunningham	Clin Microbiol Rev	2000	10885988	No
1868	2990	1495.0	56.07	28.0	Cellular motility driven by assembly and disassembly of actin filaments.	Thomas D Pollard, Gary G Borisy	Cell	2003	12600310	No
1869	1495	1495.0	43.76	43.8	Understanding organofluorine chemistry. An introduction to the C-F bond.	David O'Hagan	Chem Soc Rev	2008	18197347	No
1870	1494	1494.0	75.68	75.7	Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control.	F E Zajac	Crit Rev Biomed Eng	1989	2676342	No
1871	1494	1494.0	39.08	39.1	The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.	A S Fauci	Science	1988	3277274	No
1872	2988	1494.0	61.61	30.8	A general framework for weighted gene co-expression network analysis.	Bin Zhang, Steve Horvath	Stat Appl Genet Mol Biol	2005	16646834	Yes
1873	1494	1494.0	41.93	41.9	n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases.	Philip C Calder	Am J Clin Nutr	2006	16841861	No
1874	4479	1493.0	0.0	0.0	Hydroperoxide metabolism in mammalian organs.	B Chance, H Sies, A Boveris	Physiol Rev	1979	37532	Yes
1875	1493	1493.0	36.46	36.5	Myeloperoxidase: friend and foe.	Seymour J Klebanoff	J Leukoc Biol	2005	15689384	No
1876	7464	1492.8	151.35	30.3	Prospective identification of tumorigenic breast cancer cells.	Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F Clarke	Proc Natl Acad Sci U S A	2003	12629218	Yes
1877	2985	1492.5	0.0	0.0	Lactic dehydrogenase activity in blood.	F Wroblewski, J S Ladue	Proc Soc Exp Biol Med	1955	13273400	Yes
1878	2985	1492.5	151.9	76.0	The amyloid hypothesis of Alzheimer's disease at 25 years.	Dennis J Selkoe, John Hardy	EMBO Mol Med	2016	27025652	No
1879	1492	1492.0	40.17	40.2	Rheumatoid arthritis. Pathophysiology and implications for therapy.	E D Harris	N Engl J Med	1990	2271017	No
1880	1492	1492.0	30.42	30.4	RNA silencing in plants.	David Baulcombe	Nature	2004	15372043	No
1881	2983	1491.5	77.09	38.5	Empirical threshold values for quantitative trait mapping.	G A Churchill, R W Doerge	Genetics	1994	7851788	Yes
1882	1491	1491.0	0.0	0.0	Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies.	S Avrameas	Immunochemistry	1969	4975324	Yes
1883	2982	1491.0	76.85	38.4	Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients.	S Schulman, C Kearon	J Thromb Haemost	2005	15842354	Yes
1884	1491	1491.0	32.93	32.9	Tumor metastasis: mechanistic insights and clinical challenges.	Patricia S Steeg	Nat Med	2006	16892035	No
1885	2982	1491.0	65.66	32.8	Cancer metastasis: building a framework.	Gaorav P Gupta, Joan Massagué	Cell	2006	17110329	No
1886	1490	1490.0	0.0	0.0	Stimulated acoustic emissions from within the human auditory system.	D T Kemp	J Acoust Soc Am	1978	744838	Yes
1887	2980	1490.0	57.81	28.9	Missing pieces in the NF-kappaB puzzle.	Sankar Ghosh, Michael Karin	Cell	2002	11983155	No
1888	2978	1489.0	69.63	34.8	A novel multigene family may encode odorant receptors: a molecular basis for odor recognition.	L Buck, R Axel	Cell	1991	1840504	Yes
1889	1489	1489.0	39.61	39.6	A more meaningful scoring system for determining the severity of coronary heart disease.	G G Gensini	Am J Cardiol	1983	6823874	Yes
1890	1489	1489.0	0.0	0.0	The colorimetric determination of phosphorus.	E J King	Biochem J	1932	16744823	Yes
1891	1489	1489.0	34.83	34.8	Neurotrophin-regulated signalling pathways.	Louis F Reichardt	Philos Trans R Soc Lond B Biol Sci	2006	16939974	No
1892	1488	1488.0	0.0	0.0	Isolated removal of hypothalamic or other brain nuclei of the rat.	M Palkovits	Brain Res	1973	4747772	Yes
1893	1488	1488.0	33.84	33.8	Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone.	M B Luskin	Neuron	1993	8338665	Yes
1894	1487	1487.0	33.4	33.4	Tumor suppressor genes.	R A Weinberg	Science	1991	1659741	No
1895	2972	1486.0	81.5	40.8	Bronchopulmonary dysplasia.	A H Jobe, E Bancalari	Am J Respir Crit Care Med	2001	11401896	No
1896	2971	1485.5	159.02	79.5	Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees.	Ivica Letunic, Peer Bork	Nucleic Acids Res	2016	27095192	Yes
1897	1485	1485.0	0.0	0.0	The genetical evolution of social behaviour. II.	W D Hamilton	J Theor Biol	1964	5875340	Yes
1898	1485	1485.0	42.5	42.5	Glycobiology: Toward Understanding the Function of Sugars.	Raymond A. Dwek	Chem Rev	1996	11848770	Yes
1899	1485	1485.0	28.65	28.6	Protein kinases--the major drug targets of the twenty-first century?	Philip Cohen	Nat Rev Drug Discov	2002	12120282	No
1900	2969	1484.5	180.3	90.2	Natural Products as Sources of New Drugs from 1981 to 2014.	David J Newman, Gordon M Cragg	J Nat Prod	2016	26852623	No
1901	10390	1484.3	321.44	45.9	AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility.	Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J Olson	J Comput Chem	2009	19399780	Yes
1902	1483	1483.0	59.46	59.5	A structured interview guide for the Hamilton Depression Rating Scale.	J B Williams	Arch Gen Psychiatry	1988	3395203	Yes
1903	1483	1483.0	0.0	0.0	The mechanism of muscular contraction.	H E Huxley	Science	1969	4181952	No
1904	1483	1483.0	0.0	0.0	Cerebral vascular accidents in patients over the age of 60. II. Prognosis.	J Rankin	Scott Med J	1957	13432835	Yes
1905	2966	1483.0	61.73	30.9	Development by self-digestion: molecular mechanisms and biological functions of autophagy.	Beth Levine, Daniel J Klionsky	Dev Cell	2004	15068787	No
1906	1482	1482.0	49.35	49.4	Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson.	H J Gundersen	J Microsc	1986	3761363	Yes
1907	1482	1482.0	38.17	38.2	Aspergillus fumigatus and aspergillosis.	J P Latgé	Clin Microbiol Rev	1999	10194462	No
1908	2963	1481.5	0.0	0.0	A scaled version of the General Health Questionnaire.	D P Goldberg, V F Hillier	Psychol Med	1979	424481	Yes
1909	1481	1481.0	27.85	27.9	Aggresomes, inclusion bodies and protein aggregation.	R R Kopito	Trends Cell Biol	2000	11121744	No
1910	2962	1481.0	62.07	31.0	Coordination of circadian timing in mammals.	Steven M Reppert, David R Weaver	Nature	2002	12198538	No
1911	2961	1480.5	70.16	35.1	Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.	F Q Schafer, G R Buettner	Free Radic Biol Med	2001	11368918	No
1912	2961	1480.5	64.82	32.4	Self-assembly at all scales.	George M Whitesides, Bartosz Grzybowski	Science	2002	11923529	Yes
1913	2961	1480.5	72.48	36.2	Unravelling the pathogenesis of inflammatory bowel disease.	R J Xavier, D K Podolsky	Nature	2007	17653185	No
1914	1480	1480.0	40.65	40.6	Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms.	J A Beavo	Physiol Rev	1995	7480160	No
1915	2960	1480.0	58.33	29.2	The evolutionary fate and consequences of duplicate genes.	M Lynch, J S Conery	Science	2000	11073452	No
1916	1480	1480.0	0.0	0.0	Simple methods for "staining with lead" at high pH in electron microscopy.	M J Karnovsky	J Biophys Biochem Cytol	1961	14454024	Yes
1917	2960	1480.0	77.26	38.6	ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins.	Markus Wiederstein, Manfred J Sippl	Nucleic Acids Res	2007	17517781	Yes
1918	5919	1479.8	150.72	37.7	Most mammalian mRNAs are conserved targets of microRNAs.	Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel	Genome Res	2009	18955434	Yes
1919	1479	1479.0	39.78	39.8	Redox signaling: nitrosylation and related target interactions of nitric oxide.	J S Stamler	Cell	1994	7923362	No
1920	1479	1479.0	51.63	51.6	The self-medication hypothesis of substance use disorders: a reconsideration and recent applications.	E J Khantzian	Harv Rev Psychiatry	1997	9385000	No
1921	1479	1479.0	33.45	33.5	Ordered porous materials for emerging applications.	Mark E Davis	Nature	2002	12075343	No
1922	1479	1479.0	0.0	0.0	Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections.	R W Sperry	Proc Natl Acad Sci U S A	1963	14077501	Yes
1923	1477	1477.0	28.04	28.0	Vienna RNA secondary structure server.	Ivo L Hofacker	Nucleic Acids Res	2003	12824340	Yes
1924	1477	1477.0	42.59	42.6	Multiple imputation of discrete and continuous data by fully conditional specification.	Stef van Buuren	Stat Methods Med Res	2007	17621469	Yes
1925	1477	1477.0	43.01	43.0	Surface plasmon resonance sensors for detection of chemical and biological species.	Jirí Homola	Chem Rev	2008	18229953	No
1926	1475	1475.0	30.33	30.3	The Buccaneer software for automated model building. 1. Tracing protein chains.	Kevin Cowtan	Acta Crystallogr D Biol Crystallogr	2006	16929101	Yes
1927	4418	1472.7	0.0	0.0	The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes.	J T Dodge, C Mitchell, D J Hanahan	Arch Biochem Biophys	1963	14028302	Yes
1928	2945	1472.5	60.26	30.1	Chemokines: a new classification system and their role in immunity.	A Zlotnik, O Yoshie	Immunity	2000	10714678	No
1929	10301	1471.6	356.93	51.0	GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.	Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J Schünemann	BMJ	2008	18436948	Yes
1930	4413	1471.0	217.62	72.5	Fast and sensitive protein alignment using DIAMOND.	Benjamin Buchfink, Chao Xie, Daniel H Huson	Nat Methods	2015	25402007	Yes
1931	5882	1470.5	0.0	0.0	A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples.	M A Markwell, S M Haas, L L Bieber, N E Tolbert	Anal Biochem	1978	98070	Yes
1932	2941	1470.5	76.78	38.4	The expanding universe of T-cell subsets: Th1, Th2 and more.	T R Mosmann, S Sad	Immunol Today	1996	8820272	No
1933	1470	1470.0	33.37	33.4	The molecular logic of endocannabinoid signalling.	Daniele Piomelli	Nat Rev Neurosci	2003	14595399	No
1934	1470	1470.0	33.08	33.1	Far-field optical nanoscopy.	Stefan W Hell	Science	2007	17525330	No
1935	8816	1469.3	268.98	44.8	Cancer statistics, 2009.	Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J Thun	CA Cancer J Clin	2009	19474385	Yes
1936	1469	1469.0	0.0	0.0	Ionic blockage of sodium channels in nerve.	A M Woodhull	J Gen Physiol	1973	4541078	Yes
1937	1469	1469.0	0.0	0.0	Defective repair replication of DNA in xeroderma pigmentosum.	J E Cleaver	Nature	1968	5655953	Yes
1938	1469	1469.0	0.0	0.0	Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate.	J W Olney	Science	1969	5778021	Yes
1939	2937	1468.5	0.0	0.0	A general method for isolation of high molecular weight DNA from eukaryotes.	N Blin, D W Stafford	Nucleic Acids Res	1976	987581	Yes
1940	1468	1468.0	26.05	26.1	Histone acetylation and transcriptional regulatory mechanisms.	K Struhl	Genes Dev	1998	9499396	No
1941	1467	1467.0	0.0	0.0	Superoxide dismutases.	I Fridovich	Annu Rev Biochem	1975	1094908	No
1942	2934	1467.0	74.76	37.4	Obesity.	David W Haslam, W Philip T James	Lancet	2005	16198769	No
1943	1467	1467.0	37.27	37.3	Use and misuse of the receiver operating characteristic curve in risk prediction.	Nancy R Cook	Circulation	2007	17309939	Yes
1944	1467	1467.0	277.62	277.6	COVID-19 and mental health: A review of the existing literature.	Ravi Philip Rajkumar	Asian J Psychiatr	2020	32302935	Yes
1945	1466	1466.0	42.81	42.8	Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications.	M D Maines	FASEB J	1988	3290025	No
1946	2930	1465.0	104.82	52.4	Neutrophil recruitment and function in health and inflammation.	Elzbieta Kolaczkowska, Paul Kubes	Nat Rev Immunol	2013	23435331	No
1947	1464	1464.0	44.33	44.3	A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation.	Ozcan Erel	Clin Biochem	2004	15003729	Yes
1948	1462	1462.0	45.8	45.8	Polycystic ovary syndrome.	S Franks	N Engl J Med	1995	7651477	No
1949	1462	1462.0	35.14	35.1	Upconversion and anti-Stokes processes with f and d ions in solids.	François Auzel	Chem Rev	2004	14719973	Yes
1950	2923	1461.5	65.67	32.8	How matrix metalloproteinases regulate cell behavior.	M D Sternlicht, Z Werb	Annu Rev Cell Dev Biol	2001	11687497	No
1951	1461	1461.0	0.0	0.0	Stability of proteins: small globular proteins.	P L Privalov	Adv Protein Chem	1979	44431	No
1952	1460	1460.0	0.0	0.0	Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat.	C A Barnes	J Comp Physiol Psychol	1979	221551	Yes
1953	1460	1460.0	29.02	29.0	Macromolecular crowding: obvious but underappreciated.	R J Ellis	Trends Biochem Sci	2001	11590012	No
1954	1460	1460.0	0.0	0.0	The free amino groups of insulin.	F Sanger	Biochem J	1945	16747948	Yes
1955	4380	1460.0	136.42	45.5	Simultaneous inference in general parametric models.	Torsten Hothorn, Frank Bretz, Peter Westfall	Biom J	2008	18481363	No
1956	2919	1459.5	65.55	32.8	NF-kappaB: a key role in inflammatory diseases.	P P Tak, G S Firestein	J Clin Invest	2001	11134171	No
1957	1459	1459.0	0.0	0.0	Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues.	I E Bush	Biochem J	1952	14915960	Yes
1958	1459	1459.0	31.74	31.7	Cancer epigenomics: DNA methylomes and histone-modification maps.	Manel Esteller	Nat Rev Genet	2007	17339880	No
1959	13129	1458.8	406.05	45.1	The 1982 revised criteria for the classification of systemic lupus erythematosus.	E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J Winchester	Arthritis Rheum	1982	7138600	Yes
1960	1458	1458.0	0.0	0.0	The organization of proteins in the human red blood cell membrane. A review.	T L Steck	J Cell Biol	1974	4600883	No
1961	1458	1458.0	0.0	0.0	Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes.	P C Nowell	Cancer Res	1960	14427849	Yes
1962	4372	1457.3	0.0	0.0	Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs.	C A Winter, E A Risley, G W Nuss	Proc Soc Exp Biol Med	1962	14001233	Yes
1963	1457	1457.0	34.2	34.2	PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.	B M Spiegelman	Diabetes	1998	9568680	No
1964	1457	1457.0	45.87	45.9	Chlorophyll fluorescence: a probe of photosynthesis in vivo.	Neil R Baker	Annu Rev Plant Biol	2008	18444897	No
1965	2913	1456.5	0.0	0.0	Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses.	D H Clarke, J Casals	Am J Trop Med Hyg	1958	13571577	Yes
1966	2912	1456.0	262.15	131.1	Interactive Tree Of Life (iTOL) v4: recent updates and new developments.	Ivica Letunic, Peer Bork	Nucleic Acids Res	2019	30931475	Yes
1967	7277	1455.4	260.4	52.1	The hallmarks of aging.	Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer	Cell	2013	23746838	No
1968	2910	1455.0	0.0	0.0	A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines.	A H Anton, D F Sayre	J Pharmacol Exp Ther	1962	14013351	Yes
1969	1455	1455.0	48.98	49.0	Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains.	K Anders Ericsson	Acad Med	2004	15383395	No
1970	1453	1453.0	0.0	0.0	Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle.	H E Huxley	J Mol Biol	1963	14064165	Yes
1971	1453	1453.0	35.22	35.2	The blood-brain barrier: bottleneck in brain drug development.	William M Pardridge	NeuroRx	2005	15717053	No
1972	1452	1452.0	34.36	34.4	Binary Agrobacterium vectors for plant transformation.	M Bevan	Nucleic Acids Res	1984	6095209	Yes
1973	2903	1451.5	87.95	44.0	Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI.	P J Basser, C Pierpaoli	J Magn Reson B	1996	8661285	Yes
1974	2902	1451.0	0.0	0.0	A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms.	J A Horne, O Ostberg	Int J Chronobiol	1976	1027738	Yes
1975	2901	1450.5	66.92	33.5	Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.	C Auffray, F Rougeon	Eur J Biochem	1980	6772444	Yes
1976	4351	1450.3	123.72	41.2	The fusiform face area: a module in human extrastriate cortex specialized for face perception.	N Kanwisher, J McDermott, M M Chun	J Neurosci	1997	9151747	Yes
1977	1450	1450.0	0.0	0.0	Modality and topographic properties of single neurons of cat's somatic sensory cortex.	V B Mountcastle	J Neurophysiol	1957	13439410	Yes
1978	2899	1449.5	79.97	40.0	A rapid boiling method for the preparation of bacterial plasmids.	D S Holmes, M Quigley	Anal Biochem	1981	6269464	Yes
1979	1449	1449.0	0.0	0.0	Starch gel electrophoresis in a discontinous system of buffers.	M D Poulik	Nature	1957	13493570	Yes
1980	2897	1448.5	0.0	0.0	Assay of proteins in the presence of interfering materials.	A Bensadoun, D Weinstein	Anal Biochem	1976	1259145	Yes
1981	2897	1448.5	79.24	39.6	Materials for electrochemical capacitors.	Patrice Simon, Yury Gogotsi	Nat Mater	2008	18956000	Yes
1982	1448	1448.0	33.81	33.8	Developmental cell death: morphological diversity and multiple mechanisms.	P G Clarke	Anat Embryol (Berl)	1990	2186664	No
1983	1448	1448.0	48.57	48.6	Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC.	G A McPherson	J Pharmacol Methods	1985	3840547	Yes
1984	1448	1448.0	45.15	45.1	phangorn: phylogenetic analysis in R.	Klaus Peter Schliep	Bioinformatics	2011	21169378	Yes
1985	4341	1447.0	99.79	33.3	Click Chemistry: Diverse Chemical Function from a Few Good Reactions.	Hartmuth C. Kolb, M G Finn, K. Barry Sharpless	Angew Chem Int Ed Engl	2001	11433435	Yes
1986	5787	1446.8	0.0	0.0	The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes.	L A Sternberger, P H Hardy, J J Cuculis, H G Meyer	J Histochem Cytochem	1970	4192899	Yes
1987	4340	1446.7	96.26	32.1	Osteoclast differentiation and activation.	William J Boyle, W Scott Simonet, David L Lacey	Nature	2003	12748652	No
1988	1446	1446.0	0.0	0.0	A modified ninhydrin colorimetric analysis for amino acids.	H Rosen	Arch Biochem Biophys	1957	13412116	Yes
1989	1446	1446.0	0.0	0.0	The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases.	O V Batson	Ann Surg	1940	17857618	Yes
1990	1445	1445.0	0.0	0.0	R factor transfer in Rhizobium leguminosarum.	J E Beringer	J Gen Microbiol	1974	4612098	Yes
1991	1445	1445.0	34.78	34.8	Neuronal synchrony: a versatile code for the definition of relations?	W Singer	Neuron	1999	10677026	No
1992	1445	1445.0	44.5	44.5	Ordinary magic. Resilience processes in development.	A S Masten	Am Psychol	2001	11315249	Yes
1993	2889	1444.5	0.0	0.0	3' non-coding region sequences in eukaryotic messenger RNA.	N J Proudfoot, G G Brownlee	Nature	1976	822353	Yes
1994	10110	1444.3	219.93	31.4	Embryonic stem cell lines derived from human blastocysts.	J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M Jones	Science	1998	9804556	Yes
1995	1444	1444.0	36.26	36.3	An economic method for the fluorescent labeling of PCR fragments.	M Schuelke	Nat Biotechnol	2000	10657137	Yes
1996	1444	1444.0	40.61	40.6	Bioactive microbial metabolites.	János Bérdy	J Antibiot (Tokyo)	2005	15813176	No
1997	2887	1443.5	0.0	0.0	Mutants of Escherichia coli requiring methionine or vitamin B12.	B D Davis, E S Mingioli	J Bacteriol	1950	15436457	Yes
1998	1443	1443.0	0.0	0.0	Microbial ecology of the gastrointestinal tract.	D C Savage	Annu Rev Microbiol	1977	334036	No
1999	2883	1441.5	97.66	48.8	Thermodynamics of protein association reactions: forces contributing to stability.	P D Ross, S Subramanian	Biochemistry	1981	7248271	Yes
2000	1441	1441.0	0.0	0.0	The measurement of psychological androgyny.	S L Bem	J Consult Clin Psychol	1974	4823550	Yes
2001	2882	1441.0	0.0	0.0	Mutations of Bacteria from Virus Sensitivity to Virus Resistance.	S E Luria, M Delbrück	Genetics	1943	17247100	Yes
2002	1438	1438.0	37.43	37.4	Capacitative calcium entry revisited.	J W Putney	Cell Calcium	1990	1965707	No
2003	1438	1438.0	35.49	35.5	General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.	R A Houghten	Proc Natl Acad Sci U S A	1985	2410914	Yes
2004	1438	1438.0	0.0	0.0	A clinical method for assessing the ventilatory response to carbon dioxide.	D J Read	Australas Ann Med	1967	6032026	Yes
2005	2876	1438.0	72.36	36.2	Cell signaling by receptor tyrosine kinases.	Mark A Lemmon, Joseph Schlessinger	Cell	2010	20602996	No
2006	1438	1438.0	96.25	96.2	Making sense of implementation theories, models and frameworks.	Per Nilsen	Implement Sci	2015	25895742	Yes
2007	4313	1437.7	120.54	40.2	I-TASSER: a unified platform for automated protein structure and function prediction.	Ambrish Roy, Alper Kucukural, Yang Zhang	Nat Protoc	2010	20360767	Yes
2008	4309	1436.3	93.28	31.1	NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.	S Ghosh, M J May, E B Kopp	Annu Rev Immunol	1998	9597130	No
2009	4307	1435.7	111.15	37.1	Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system.	B Fischl, M I Sereno, A M Dale	Neuroimage	1999	9931269	Yes
2010	1435	1435.0	34.28	34.3	Oxidative stress in Parkinson's disease.	Peter Jenner	Ann Neurol	2003	12666096	No
2011	4304	1434.7	165.34	55.1	Multiple imputation using chained equations: Issues and guidance for practice.	Ian R White, Patrick Royston, Angela M Wood	Stat Med	2011	21225900	Yes
2012	2869	1434.5	91.71	45.9	Oxidative stress and diabetic complications.	Ferdinando Giacco, Michael Brownlee	Circ Res	2010	21030723	No
2013	2868	1434.0	74.46	37.2	Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators.	I Issemann, S Green	Nature	1990	2129546	Yes
2014	1434	1434.0	39.11	39.1	A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology.	J Engel	Epilepsia	2001	11422340	Yes
2015	1434	1434.0	32.32	32.3	Hyaluronan: from extracellular glue to pericellular cue.	Bryan P Toole	Nat Rev Cancer	2004	15229478	No
2016	2867	1433.5	90.59	45.3	Functional architecture of basal ganglia circuits: neural substrates of parallel processing.	G E Alexander, M D Crutcher	Trends Neurosci	1990	1695401	No
2017	1433	1433.0	32.15	32.1	The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes.	S E Kahn	Diabetologia	2003	12637977	No
2018	1433	1433.0	45.67	45.7	The law of attrition.	Gunther Eysenbach	J Med Internet Res	2005	15829473	Yes
2019	1433	1433.0	49.14	49.1	A Social Neuroscience Perspective on Adolescent Risk-Taking.	Laurence Steinberg	Dev Rev	2008	18509515	Yes
2020	1432	1432.0	31.47	31.5	Protein misfolding, evolution and disease.	C M Dobson	Trends Biochem Sci	1999	10470028	No
2021	1432	1432.0	39.86	39.9	Leishmaniasis: current situation and new perspectives.	P Desjeux	Comp Immunol Microbiol Infect Dis	2004	15225981	No
2022	1432	1432.0	125.01	125.0	Obesity: global epidemiology and pathogenesis.	Matthias Blüher	Nat Rev Endocrinol	2019	30814686	No
2023	18610	1431.5	496.09	38.2	Clustal W and Clustal X version 2.0.	M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G Higgins	Bioinformatics	2007	17846036	Yes
2024	1431	1431.0	36.06	36.1	Clinical features of metastatic bone disease and risk of skeletal morbidity.	Robert E Coleman	Clin Cancer Res	2006	17062708	No
2025	4288	1429.3	130.58	43.5	GSVA: gene set variation analysis for microarray and RNA-seq data.	Sonja Hänzelmann, Robert Castelo, Justin Guinney	BMC Bioinformatics	2013	23323831	Yes
2026	11433	1429.1	339.91	42.5	The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment.	Ziad S Nasreddine, Natalie A Phillips, Valérie Bédirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard Chertkow	J Am Geriatr Soc	2005	15817019	Yes
2027	1429	1429.0	44.63	44.6	Equipoise and the ethics of clinical research.	B Freedman	N Engl J Med	1987	3600702	Yes
2028	2858	1429.0	66.65	33.3	The MAPK signaling cascade.	R Seger, E G Krebs	FASEB J	1995	7601337	No
2029	4287	1429.0	92.66	30.9	TOR signaling in growth and metabolism.	Stephan Wullschleger, Robbie Loewith, Michael N Hall	Cell	2006	16469695	No
2030	2858	1429.0	78.49	39.2	The gut microbiota shapes intestinal immune responses during health and disease.	June L Round, Sarkis K Mazmanian	Nat Rev Immunol	2009	19343057	No
2031	2858	1429.0	146.84	73.4	Cancer immunotherapy using checkpoint blockade.	Antoni Ribas, Jedd D Wolchok	Science	2018	29567705	No
2032	4286	1428.7	120.05	40.0	trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses.	Salvador Capella-Gutiérrez, José M Silla-Martínez, Toni Gabaldón	Bioinformatics	2009	19505945	Yes
2033	2857	1428.5	78.24	39.1	Angiogenesis.	J Folkman, Y Shing	J Biol Chem	1992	1375931	No
2034	2855	1427.5	78.03	39.0	Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper.	B R Celli, W MacNee	Eur Respir J	2004	15219010	No
2035	2853	1426.5	0.0	0.0	Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.	H J Bloom, W W Richardson	Br J Cancer	1957	13499785	Yes
2036	2852	1426.0	85.32	42.7	The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.	J D Hayes, D J Pulford	Crit Rev Biochem Mol Biol	1995	8770536	No
2037	2851	1425.5	106.46	53.2	Universal chemical assay for the detection and determination of siderophores.	B Schwyn, J B Neilands	Anal Biochem	1987	2952030	Yes
2038	2850	1425.0	85.37	42.7	From best evidence to best practice: effective implementation of change in patients' care.	Richard Grol, Jeremy Grimshaw	Lancet	2003	14568747	No
2039	1425	1425.0	31.47	31.5	Autophagy: from phenomenology to molecular understanding in less than a decade.	Daniel J Klionsky	Nat Rev Mol Cell Biol	2007	17712358	No
2040	1425	1425.0	36.49	36.5	Marine viruses--major players in the global ecosystem.	Curtis A Suttle	Nat Rev Microbiol	2007	17853907	No
2041	1425	1425.0	44.36	44.4	Signal transduction by reactive oxygen species.	Toren Finkel	J Cell Biol	2011	21746850	No
2042	1424	1424.0	0.0	0.0	Human cardiovascular adjustments to exercise and thermal stress.	L B Rowell	Physiol Rev	1974	4587247	No
2043	1424	1424.0	30.29	30.3	Neurotrophins as synaptic modulators.	M M Poo	Nat Rev Neurosci	2001	11253356	No
2044	2848	1424.0	77.58	38.8	Lipid rafts as a membrane-organizing principle.	Daniel Lingwood, Kai Simons	Science	2010	20044567	No
2045	1423	1423.0	0.0	0.0	Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis.	M P Blaustein	Am J Physiol	1977	324293	No
2046	1423	1423.0	36.01	36.0	Stress and hippocampal plasticity.	B S McEwen	Annu Rev Neurosci	1999	10202533	No
2047	5692	1423.0	126.56	31.6	Probability-based protein identification by searching sequence databases using mass spectrometry data.	D N Perkins, D J Pappin, D M Creasy, J S Cottrell	Electrophoresis	1999	10612281	Yes
2048	1423	1423.0	0.0	0.0	Potential, Impedance, And Rectification In Membranes.	D E Goldman	J Gen Physiol	1943	19873371	Yes
2049	15651	1422.8	515.75	46.9	A new equation to estimate glomerular filtration rate.	Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef Coresh	Ann Intern Med	2009	19414839	Yes
2050	8537	1422.8	283.78	47.3	TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions.	Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg	Genome Biol	2013	23618408	Yes
2051	2844	1422.0	83.37	41.7	What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes.	J Zhang, K F Yu	JAMA	1998	9832001	Yes
2052	2843	1421.5	93.77	46.9	The efficiency of systematic sampling in stereology and its prediction.	H J Gundersen, E B Jensen	J Microsc	1987	3430576	Yes
2053	8529	1421.5	207.07	34.5	GROMACS: fast, flexible, and free.	David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C Berendsen	J Comput Chem	2005	16211538	Yes
2054	1421	1421.0	47.19	47.2	The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme.	Poul Erik Petersen	Community Dent Oral Epidemiol	2003	15015736	Yes
2055	1421	1421.0	53.59	53.6	Cytokines in inflammatory bowel disease.	Markus F Neurath	Nat Rev Immunol	2014	24751956	No
2056	1420	1420.0	37.67	37.7	Cell and environment interactions in tumor microregions: the multicell spheroid model.	R M Sutherland	Science	1988	2451290	Yes
2057	1420	1420.0	0.0	0.0	Codon--anticodon pairing: the wobble hypothesis.	F H Crick	J Mol Biol	1966	5969078	Yes
2058	1420	1420.0	46.44	46.4	SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test.	B P O'Connor	Behav Res Methods Instrum Comput	2000	11029811	Yes
2059	1420	1420.0	39.44	39.4	Stress and depression.	Constance Hammen	Annu Rev Clin Psychol	2005	17716090	No
2060	11349	1418.6	509.44	63.7	The SILVA ribosomal RNA gene database project: improved data processing and web-based tools.	Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jörg Peplies, Frank Oliver Glöckner	Nucleic Acids Res	2013	23193283	Yes
2061	1417	1417.0	26.74	26.7	Ubiquitin-dependent protein degradation.	M Hochstrasser	Annu Rev Genet	1996	8982460	No
2062	1417	1417.0	50.16	50.2	Multimodal approach to control postoperative pathophysiology and rehabilitation.	H Kehlet	Br J Anaesth	1997	9175983	No
2063	2834	1417.0	57.71	28.9	Intrinsically unstructured proteins and their functions.	H Jane Dyson, Peter E Wright	Nat Rev Mol Cell Biol	2005	15738986	No
2064	2833	1416.5	123.61	61.8	The Emerging Hallmarks of Cancer Metabolism.	Natalya N Pavlova, Craig B Thompson	Cell Metab	2016	26771115	No
2065	7082	1416.4	153.22	30.6	Site-directed mutagenesis by overlap extension using the polymerase chain reaction.	S N Ho, H D Hunt, R M Horton, J K Pullen, L R Pease	Gene	1989	2744487	Yes
2066	1416	1416.0	45.62	45.6	Apoptosis in cancer: from pathogenesis to treatment.	Rebecca S Y Wong	J Exp Clin Cancer Res	2011	21943236	No
2067	4246	1415.3	93.71	31.2	Telomeres shorten during ageing of human fibroblasts.	C B Harley, A B Futcher, C W Greider	Nature	1990	2342578	Yes
2068	1414	1414.0	0.0	0.0	Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look.	J Wyman	Adv Protein Chem	1964	14268785	No
2069	1414	1414.0	37.84	37.8	Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease.	Michael F Holick	Am J Clin Nutr	2004	15585788	No
2070	1413	1413.0	32.31	32.3	The cadherins: cell-cell adhesion molecules controlling animal morphogenesis.	M Takeichi	Development	1988	3048970	No
2071	2826	1413.0	0.0	0.0	Peptidoglycan types of bacterial cell walls and their taxonomic implications.	K H Schleifer, O Kandler	Bacteriol Rev	1972	4568761	No
2072	2826	1413.0	0.0	0.0	Brain stem reticular formation and activation of the EEG.	G Moruzzi, H W Magoun	Electroencephalogr Clin Neurophysiol	1949	18421835	Yes
2073	1412	1412.0	0.0	0.0	Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.	K S McCully	Am J Pathol	1969	5792556	Yes
2074	1412	1412.0	36.27	36.3	Interoception: the sense of the physiological condition of the body.	A D Craig	Curr Opin Neurobiol	2003	12965300	No
2075	2824	1412.0	102.44	51.2	The future of immune checkpoint therapy.	Padmanee Sharma, James P Allison	Science	2015	25838373	No
2076	1411	1411.0	29.24	29.2	Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.	S S Ferguson	Pharmacol Rev	2001	11171937	No
2077	1411	1411.0	35.25	35.2	The amygdala modulates the consolidation of memories of emotionally arousing experiences.	James L McGaugh	Annu Rev Neurosci	2004	15217324	No
2078	1411	1411.0	31.03	31.0	Critical period plasticity in local cortical circuits.	Takao K Hensch	Nat Rev Neurosci	2005	16261181	No
2079	2822	1411.0	99.97	50.0	Neoantigens in cancer immunotherapy.	Ton N Schumacher, Robert D Schreiber	Science	2015	25838375	No
2080	4231	1410.3	88.44	29.5	Toll-like receptors.	Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira	Annu Rev Immunol	2003	12524386	No
2081	2820	1410.0	86.15	43.1	Porosity of 3D biomaterial scaffolds and osteogenesis.	Vassilis Karageorgiou, David Kaplan	Biomaterials	2005	15860204	No
2082	2820	1410.0	81.76	40.9	Genome regulation by long noncoding RNAs.	John L Rinn, Howard Y Chang	Annu Rev Biochem	2012	22663078	No
2083	1410	1410.0	67.25	67.2	Structure, Function, and Evolution of Coronavirus Spike Proteins.	Fang Li	Annu Rev Virol	2016	27578435	No
2084	1409	1409.0	33.19	33.2	Functions of ceramide in coordinating cellular responses to stress.	Y A Hannun	Science	1996	8943189	No
2085	2817	1408.5	63.03	31.5	Raster3D Version 2.0. A program for photorealistic molecular graphics.	E A Merritt, M E Murphy	Acta Crystallogr D Biol Crystallogr	1994	15299354	Yes
2086	2816	1408.0	84.75	42.4	Intracellular pH.	A Roos, W F Boron	Physiol Rev	1981	7012859	No
2087	1408	1408.0	43.77	43.8	The functional gastrointestinal disorders and the Rome III process.	Douglas A Drossman	Gastroenterology	2006	16678553	No
2088	2815	1407.5	65.73	32.9	The DNA damage response: making it safe to play with knives.	Alberto Ciccia, Stephen J Elledge	Mol Cell	2010	20965415	No
2089	1407	1407.0	36.05	36.0	Reconciling the chemistry and biology of reactive oxygen species.	Christine C Winterbourn	Nat Chem Biol	2008	18421291	No
2090	2812	1406.0	0.0	0.0	Empirical predictions of protein conformation.	P Y Chou, G D Fasman	Annu Rev Biochem	1978	354496	No
2091	1406	1406.0	35.02	35.0	Origin, biogenesis, and activity of plant microRNAs.	Olivier Voinnet	Cell	2009	19239888	No
2092	5623	1405.8	189.45	47.4	Common method biases in behavioral research: a critical review of the literature and recommended remedies.	Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P Podsakoff	J Appl Psychol	2003	14516251	No
2093	2810	1405.0	53.86	26.9	T-cell antigen receptor genes and T-cell recognition.	M M Davis, P J Bjorkman	Nature	1988	3043226	No
2094	1405	1405.0	40.97	41.0	The aging process.	D Harman	Proc Natl Acad Sci U S A	1981	6947277	Yes
2095	2810	1405.0	0.0	0.0	The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.	E G Gray, V P Whittaker	J Anat	1962	13901297	Yes
2096	1405	1405.0	58.89	58.9	Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement.	Virginia A Moyer	Ann Intern Med	2014	24378917	No
2097	1405	1405.0	63.23	63.2	Nonalcoholic fatty liver disease: a systematic review.	Mary E Rinella	JAMA	2015	26057287	No
2098	1405	1405.0	0.0	0.0	A Protection Motivation Theory of Fear Appeals and Attitude Change1.	Ronald W Rogers	J Psychol	1975	28136248	Yes
2099	4212	1404.0	141.78	47.3	Vascular endothelial cells synthesize nitric oxide from L-arginine.	R M Palmer, D S Ashton, S Moncada	Nature	1988	3131684	Yes
2100	1404	1404.0	52.66	52.7	Cardiac valve surgery--the "French correction".	A Carpentier	J Thorac Cardiovasc Surg	1983	6887954	Yes
2101	1404	1404.0	0.0	0.0	The Relation Of Recombination To Mutational Advance.	H J Muller	Mutat Res	1964	14195748	Yes
2102	1403	1403.0	32.9	32.9	Speculations on the functions of the major heat shock and glucose-regulated proteins.	H R Pelham	Cell	1986	2944601	Yes
2103	1403	1403.0	34.02	34.0	The use of nanocrystals in biological detection.	Paul Alivisatos	Nat Biotechnol	2004	14704706	Yes
2104	2805	1402.5	66.99	33.5	Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress.	H Cai, D G Harrison	Circ Res	2000	11073878	No
2105	1402	1402.0	32.2	32.2	The Unified Medical Language System (UMLS): integrating biomedical terminology.	Olivier Bodenreider	Nucleic Acids Res	2004	14681409	Yes
2106	1402	1402.0	70.24	70.2	Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial.	Kevin A Hallgren	Tutor Quant Methods Psychol	2012	22833776	Yes
2107	2803	1401.5	62.77	31.4	Cellular senescence: when bad things happen to good cells.	Judith Campisi, Fabrizio d'Adda di Fagagna	Nat Rev Mol Cell Biol	2007	17667954	No
2108	1401	1401.0	49.43	49.4	Colorimetric determination of phospholipids with ammonium ferrothiocyanate.	J C Stewart	Anal Biochem	1980	6892980	Yes
2109	2801	1400.5	73.15	36.6	Abdominal obesity and metabolic syndrome.	Jean-Pierre Després, Isabelle Lemieux	Nature	2006	17167477	No
2110	1400	1400.0	0.0	0.0	Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion.	S S Lehrer	Biochemistry	1971	5119250	Yes
2111	1400	1400.0	37.1	37.1	The world health report 2002 - reducing risks, promoting healthy life.	J J Guilbert	Educ Health (Abingdon)	2003	14741909	Yes
2112	1399	1399.0	33.56	33.6	The basic science of gene therapy.	R C Mulligan	Science	1993	8493530	No
2113	1399	1399.0	25.67	25.7	The DNA methyltransferases of mammals.	T H Bestor	Hum Mol Genet	2000	11005794	No
2114	2797	1398.5	77.19	38.6	Transforming growth factor beta in tissue fibrosis.	W A Border, N A Noble	N Engl J Med	1994	7935686	No
2115	1398	1398.0	39.96	40.0	Isolation and cultivation of Lyme disease spirochetes.	A G Barbour	Yale J Biol Med	1984	6393604	Yes
2116	1398	1398.0	47.64	47.6	Inflammation in atherosclerosis.	Peter Libby	Arterioscler Thromb Vasc Biol	2012	22895665	No
2117	5591	1397.8	275.68	68.9	Prevalence of childhood and adult obesity in the United States, 2011-2012.	Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M Flegal	JAMA	2014	24570244	Yes
2118	12576	1397.3	391.19	43.5	The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10.	D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C Dunbar	J Clin Psychiatry	1998	9881538	No
2119	1397	1397.0	26.37	26.4	NK cell receptors.	L L Lanier	Annu Rev Immunol	1998	9597134	No
2120	2794	1397.0	87.5	43.8	Quality control and preprocessing of metagenomic datasets.	Robert Schmieder, Robert Edwards	Bioinformatics	2011	21278185	Yes
2121	2792	1396.0	71.09	35.5	CLUSTAL: a package for performing multiple sequence alignment on a microcomputer.	D G Higgins, P M Sharp	Gene	1988	3243435	Yes
2122	1396	1396.0	0.0	0.0	Selection of successive tumour lines for metastasis.	I J Fidler	Nat New Biol	1973	4512654	Yes
2123	1396	1396.0	39.02	39.0	Emotion regulation: affective, cognitive, and social consequences.	James J Gross	Psychophysiology	2002	12212647	No
2124	2792	1396.0	55.22	27.6	Cancer genes and the pathways they control.	Bert Vogelstein, Kenneth W Kinzler	Nat Med	2004	15286780	No
2125	2790	1395.0	102.74	51.4	Van der Waals heterostructures.	A K Geim, I V Grigorieva	Nature	2013	23887427	Yes
2126	4184	1394.7	108.15	36.1	The metabolic syndrome.	Robert H Eckel, Scott M Grundy, Paul Z Zimmet	Lancet	2005	15836891	No
2127	2789	1394.5	0.0	0.0	Prediction of protein conformation.	P Y Chou, G D Fasman	Biochemistry	1974	4358940	Yes
2128	2789	1394.5	0.0	0.0	The effect of sodium ions on the electrical activity of giant axon of the squid.	A L Hodgkin, B Katz	J Physiol	1949	18128147	Yes
2129	2788	1394.0	61.81	30.9	An essential role for NF-kappaB in preventing TNF-alpha-induced cell death.	A A Beg, D Baltimore	Science	1996	8864118	Yes
2130	2788	1394.0	61.41	30.7	Escaping free-energy minima.	Alessandro Laio, Michele Parrinello	Proc Natl Acad Sci U S A	2002	12271136	Yes
2131	2787	1393.5	68.58	34.3	Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.	E S Lander, D Botstein	Genetics	1989	2563713	Yes
2132	1393	1393.0	40.6	40.6	Recent developments in isocyanide based multicomponent reactions in applied chemistry.	Alexander Dömling	Chem Rev	2006	16402771	No
2133	1393	1393.0	77.07	77.1	Hydrogel: Preparation, characterization, and applications: A review.	Enas M Ahmed	J Adv Res	2015	25750745	No
2134	1393	1393.0	114.99	115.0	High-performance medicine: the convergence of human and artificial intelligence.	Eric J Topol	Nat Med	2019	30617339	No
2135	2785	1392.5	117.02	58.5	Alginate: properties and biomedical applications.	Kuen Yong Lee, David J Mooney	Prog Polym Sci	2012	22125349	Yes
2136	4177	1392.3	150.21	50.1	CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting.	Teresa C Horan, Mary Andrus, Margaret A Dudeck	Am J Infect Control	2008	18538699	No
2137	1392	1392.0	32.04	32.0	Protein kinase C: structure, function, and regulation.	A C Newton	J Biol Chem	1995	7499357	No
2138	1392	1392.0	32.36	32.4	Cell signaling. H2O2, a necessary evil for cell signaling.	Sue Goo Rhee	Science	2006	16809515	Yes
2139	4174	1391.3	108.66	36.2	How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.	R M Sapolsky, L M Romero, A U Munck	Endocr Rev	2000	10696570	No
2140	4172	1390.7	128.76	42.9	Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria.	S van der Linden, H A Valkenburg, A Cats	Arthritis Rheum	1984	6231933	Yes
2141	2781	1390.5	0.0	0.0	Microdetermination of long-chain fatty acids in plasma and tissues.	V P Dole, H Meinertz	J Biol Chem	1960	13817286	Yes
2142	2779	1389.5	0.0	0.0	Selective loss of central cholinergic neurons in Alzheimer's disease.	P Davies, A J Maloney	Lancet	1976	63862	Yes
2143	1389	1389.0	43.7	43.7	The Neuropsychiatric Inventory: assessing psychopathology in dementia patients.	J L Cummings	Neurology	1997	9153155	No
2144	4167	1389.0	0.0	0.0	Improved method for the determination of blood glutathione.	E Beutler, O Duron, B M Kelly	J Lab Clin Med	1963	13967893	Yes
2145	1389	1389.0	41.53	41.5	Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research.	M Robin DiMatteo	Med Care	2004	15076819	Yes
2146	1389	1389.0	34.64	34.6	Fast and robust fixed-point algorithms for independent component analysis.	A Hyvärinen	IEEE Trans Neural Netw	1999	18252563	Yes
2147	2777	1388.5	0.0	0.0	Synchronization of Plasmodium falciparum erythrocytic stages in culture.	C Lambros, J P Vanderberg	J Parasitol	1979	383936	Yes
2148	1388	1388.0	46.13	46.1	Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology.	N Krieger	Am J Public Health	1992	1566949	Yes
2149	2776	1388.0	59.04	29.5	The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.	M S Brown, J L Goldstein	Cell	1997	9150132	No
2150	1388	1388.0	31.22	31.2	Mitochondria: dynamic organelles in disease, aging, and development.	David C Chan	Cell	2006	16814712	No
2151	8327	1387.8	505.48	84.2	DADA2: High-resolution sample inference from Illumina amplicon data.	Benjamin J Callahan, Paul J McMurdie, Michael J Rosen, Andrew W Han, Amy Jo A Johnson, Susan P Holmes	Nat Methods	2016	27214047	Yes
2152	2775	1387.5	0.0	0.0	A method of trace iodination of proteins for immunologic studies.	P J McConahey, F J Dixon	Int Arch Allergy Appl Immunol	1966	4160044	Yes
2153	2775	1387.5	105.82	52.9	The M1 and M2 paradigm of macrophage activation: time for reassessment.	Fernando O Martinez, Siamon Gordon	F1000Prime Rep	2014	24669294	No
2154	2774	1387.0	87.25	43.6	Unidentified curved bacilli on gastric epithelium in active chronic gastritis.	J R Warren, B Marshall	Lancet	1983	6134060	Yes
2155	2774	1387.0	78.38	39.2	Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis.	F D Lublin, S C Reingold	Neurology	1996	8780061	Yes
2156	2773	1386.5	167.72	83.9	Rating systems in the evaluation of knee ligament injuries.	Y Tegner, J Lysholm	Clin Orthop Relat Res	1985	4028566	Yes
2157	1386	1386.0	56.5	56.5	MorphoJ: an integrated software package for geometric morphometrics.	Christian Peter Klingenberg	Mol Ecol Resour	2011	21429143	Yes
2158	2771	1385.5	0.0	0.0	Immunoassay of endogenous plasma insulin in man.	R S Yalow, S A Berson	J Clin Invest	1960	13846364	Yes
2159	1385	1385.0	36.84	36.8	The epidemiology of venous thromboembolism.	Richard H White	Circulation	2003	12814979	No
2160	2769	1384.5	82.34	41.2	Glycine potentiates the NMDA response in cultured mouse brain neurons.	J W Johnson, P Ascher	Nature	1987	2433595	Yes
2161	2769	1384.5	71.66	35.8	A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.	J Messing, J Vieira	Gene	1982	6295880	Yes
2162	2769	1384.5	54.27	27.1	Autophagy as a regulated pathway of cellular degradation.	D J Klionsky, S D Emr	Science	2000	11099404	No
2163	1384	1384.0	67.25	67.2	Chronic illness as biographical disruption.	M Bury	Sociol Health Illn	1982	10260456	Yes
2164	8304	1384.0	200.8	33.5	Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.	Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O Lötvall	Nat Cell Biol	2007	17486113	Yes
2165	1383	1383.0	0.0	0.0	Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions.	W C Schneider	J Biol Chem	1948	18886166	Yes
2166	1382	1382.0	46.45	46.5	Gene flow and the geographic structure of natural populations.	M Slatkin	Science	1987	3576198	Yes
2167	1382	1382.0	30.29	30.3	Topoisomerase I inhibitors: camptothecins and beyond.	Yves Pommier	Nat Rev Cancer	2006	16990856	No
2168	2763	1381.5	69.0	34.5	Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule.	M D Pierschbacher, E Ruoslahti	Nature	1984	6325925	Yes
2169	2763	1381.5	0.0	0.0	Virus interference. I. The interferon.	A Isaacs, J Lindenmann	Proc R Soc Lond B Biol Sci	1957	13465720	Yes
2170	2760	1380.0	95.16	47.6	How useful is SBF in predicting in vivo bone bioactivity?	Tadashi Kokubo, Hiroaki Takadama	Biomaterials	2006	16448693	No
2171	1379	1379.0	0.0	0.0	Mate selection-a selection for a handicap.	A Zahavi	J Theor Biol	1975	1195756	Yes
2172	2756	1378.0	69.54	34.8	Molecular beacons: probes that fluoresce upon hybridization.	S Tyagi, F R Kramer	Nat Biotechnol	1996	9630890	Yes
2173	2756	1378.0	51.92	26.0	Oncogenic kinase signalling.	P Blume-Jensen, T Hunter	Nature	2001	11357143	No
2174	1377	1377.0	89.31	89.3	The three column spine and its significance in the classification of acute thoracolumbar spinal injuries.	F Denis	Spine (Phila Pa 1976)	1983	6670016	Yes
2175	1377	1377.0	39.91	39.9	Treatment of infections associated with surgical implants.	Rabih O Darouiche	N Engl J Med	2004	15070792	No
2176	2754	1377.0	59.21	29.6	Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry.	Joshua E Elias, Steven P Gygi	Nat Methods	2007	17327847	Yes
2177	2754	1377.0	137.37	68.7	Making sense of Cronbach's alpha.	Mohsen Tavakol, Reg Dennick	Int J Med Educ	2011	28029643	No
2178	2753	1376.5	83.5	41.8	Accessories to the crime: functions of cells recruited to the tumor microenvironment.	Douglas Hanahan, Lisa M Coussens	Cancer Cell	2012	22439926	No
2179	4126	1375.3	104.24	34.7	Membrane lipids: where they are and how they behave.	Gerrit van Meer, Dennis R Voelker, Gerald W Feigenson	Nat Rev Mol Cell Biol	2008	18216768	No
2180	2750	1375.0	0.0	0.0	Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G.	E Engvall, P Perlmann	Immunochemistry	1971	5135623	Yes
2181	1375	1375.0	57.31	57.3	α-band oscillations, attention, and controlled access to stored information.	Wolfgang Klimesch	Trends Cogn Sci	2012	23141428	No
2182	2749	1374.5	86.37	43.2	Performing the exact test of Hardy-Weinberg proportion for multiple alleles.	S W Guo, E A Thompson	Biometrics	1992	1637966	Yes
2183	2749	1374.5	82.78	41.4	The cortical organization of speech processing.	Gregory Hickok, David Poeppel	Nat Rev Neurosci	2007	17431404	No
2184	4122	1374.0	99.5	33.2	Long non-coding RNAs: insights into functions.	Tim R Mercer, Marcel E Dinger, John S Mattick	Nat Rev Genet	2009	19188922	No
2185	1374	1374.0	49.27	49.3	Phase retrieval algorithms: a comparison.	J R Fienup	Appl Opt	1982	20396114	Yes
2186	2747	1373.5	54.74	27.4	Wnt signalling in stem cells and cancer.	Tannishtha Reya, Hans Clevers	Nature	2005	15829953	No
2187	1373	1373.0	0.0	0.0	An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals.	O Smithies	Biochem J	1959	13638269	Yes
2188	1373	1373.0	40.17	40.2	Graphene transistors.	Frank Schwierz	Nat Nanotechnol	2010	20512128	Yes
2189	2744	1372.0	99.34	49.7	Biology of disease: free radicals and tissue injury.	B A Freeman, J D Crapo	Lab Invest	1982	6290784	No
2190	2744	1372.0	70.49	35.2	Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins.	D Marion, K Wüthrich	Biochem Biophys Res Commun	1983	6307308	Yes
2191	1372	1372.0	46.03	46.0	Interleukin-1.	C A Dinarello	Rev Infect Dis	1984	6369481	No
2192	1372	1372.0	34.81	34.8	Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides.	Y Shai	Biochim Biophys Acta	1999	10590302	No
2193	1372	1372.0	35.24	35.2	The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.	T Szkudelski	Physiol Res	2001	11829314	No
2194	1372	1372.0	0.0	0.0	Effects of varying the vehicle for OsO4 in tissue fixation.	J B Caulfield	J Biophys Biochem Cytol	1957	13475399	Yes
2195	2743	1371.5	0.0	0.0	Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.	A J Berk, P A Sharp	Cell	1977	922889	Yes
2196	2743	1371.5	94.46	47.2	The framing of decisions and the psychology of choice.	A Tversky, D Kahneman	Science	1981	7455683	Yes
2197	1371	1371.0	54.26	54.3	Reliability and factor analysis of the Epworth Sleepiness Scale.	M W Johns	Sleep	1992	1519015	Yes
2198	1371	1371.0	41.03	41.0	Strong localization of photons in certain disordered dielectric superlattices.	John	Phys Rev Lett	1987	10034761	Yes
2199	1371	1371.0	36.91	36.9	A note on robust variance estimation for cluster-correlated data.	R L Williams	Biometrics	2000	10877330	Yes
2200	5483	1370.8	189.9	47.5	Guidelines for the process of cross-cultural adaptation of self-report measures.	D E Beaton, C Bombardier, F Guillemin, M B Ferraz	Spine (Phila Pa 1976)	2000	11124735	No
2201	1370	1370.0	0.0	0.0	Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein.	T Spector	Anal Biochem	1978	655375	Yes
2202	2740	1370.0	61.94	31.0	The pathophysiology and treatment of sepsis.	Richard S Hotchkiss, Irene E Karl	N Engl J Med	2003	12519925	No
2203	1369	1369.0	0.0	0.0	Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.	J R David	Proc Natl Acad Sci U S A	1966	5229858	Yes
2204	1369	1369.0	30.45	30.4	Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles.	M Kozak	Microbiol Rev	1983	6343825	No
2205	1368	1368.0	58.16	58.2	The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence.	E J Khantzian	Am J Psychiatry	1985	3904487	No
2206	1368	1368.0	0.0	0.0	The prevalence of 'alexithymic' characteristics in psychosomatic patients.	P E Sifneos	Psychother Psychosom	1973	4770536	Yes
2207	1368	1368.0	44.29	44.3	Formation of glasses from liquids and biopolymers.	C A Angell	Science	1995	17770101	Yes
2208	1367	1367.0	34.17	34.2	The 'effective number of codons' used in a gene.	F Wright	Gene	1990	2110097	Yes
2209	4098	1366.0	0.0	0.0	Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins.	J Garnier, D J Osguthorpe, B Robson	J Mol Biol	1978	642007	Yes
2210	1366	1366.0	55.12	55.1	An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results.	J Kabat-Zinn	Gen Hosp Psychiatry	1982	7042457	Yes
2211	1366	1366.0	27.15	27.1	Natively unfolded proteins: a point where biology waits for physics.	Vladimir N Uversky	Protein Sci	2002	11910019	No
2212	1366	1366.0	33.34	33.3	Drug-induced prolongation of the QT interval.	Dan M Roden	N Engl J Med	2004	14999113	No
2213	5462	1365.5	161.3	40.3	Reversible middle cerebral artery occlusion without craniectomy in rats.	E Z Longa, P R Weinstein, S Carlson, R Cummins	Stroke	1989	2643202	Yes
2214	2731	1365.5	72.67	36.3	Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments.	Gerard Talavera, Jose Castresana	Syst Biol	2007	17654362	Yes
2215	1365	1365.0	32.69	32.7	Proinflammatory cytokines.	C A Dinarello	Chest	2000	10936147	No
2216	8186	1364.3	246.49	41.1	A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.	Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier	Science	2012	22745249	Yes
2217	1364	1364.0	46.92	46.9	Multiple calcium channels and neuronal function.	R J Miller	Science	1987	2432656	No
2218	1364	1364.0	60.83	60.8	Human agency in social cognitive theory.	A Bandura	Am Psychol	1989	2782727	Yes
2219	1364	1364.0	0.0	0.0	The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models.	R C Lewontin	Genetics	1964	17248194	Yes
2220	1364	1364.0	30.71	30.7	The tumor microenvironment and its role in promoting tumor growth.	T L Whiteside	Oncogene	2008	18836471	No
2221	1364	1364.0	48.86	48.9	The role of senescent cells in ageing.	Jan M van Deursen	Nature	2014	24848057	No
2222	1363	1363.0	33.69	33.7	Tobacco smoke carcinogens and lung cancer.	S S Hecht	J Natl Cancer Inst	1999	10413421	No
2223	1363	1363.0	0.0	0.0	A New Weighting System For Mean Surface Temperature Of The Human Body.	N L Ramanathan	J Appl Physiol	1964	14173555	Yes
2224	2725	1362.5	0.0	0.0	A protein sequenator.	P Edman, G Begg	Eur J Biochem	1967	6059350	Yes
2225	2725	1362.5	126.38	63.2	Parkinson's disease.	Lorraine V Kalia, Anthony E Lang	Lancet	2015	25904081	No
2226	2724	1362.0	0.0	0.0	Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents.	L F Berkman, S L Syme	Am J Epidemiol	1979	425958	Yes
2227	1362	1362.0	42.04	42.0	Biological basis of the behavior of sick animals.	B L Hart	Neurosci Biobehav Rev	1988	3050629	No
2228	4086	1362.0	144.47	48.2	Structure-antioxidant activity relationships of flavonoids and phenolic acids.	C A Rice-Evans, N J Miller, G Paganga	Free Radic Biol Med	1996	8743980	Yes
2229	2722	1361.0	77.55	38.8	Mortality by cause for eight regions of the world: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9142060	Yes
2230	1361	1361.0	28.42	28.4	Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators.	R I Morimoto	Genes Dev	1998	9869631	No
2231	1361	1361.0	29.65	29.6	Cancer of the ovary.	Stephen A Cannistra	N Engl J Med	2004	15590954	No
2232	1361	1361.0	38.76	38.8	The debate over dopamine's role in reward: the case for incentive salience.	Kent C Berridge	Psychopharmacology (Berl)	2007	17072591	No
2233	2720	1360.0	79.77	39.9	Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9164317	Yes
2234	2720	1360.0	364.51	182.3	WHO Declares COVID-19 a Pandemic.	Domenico Cucinotta, Maurizio Vanelli	Acta Biomed	2020	32191675	Yes
2235	2719	1359.5	72.07	36.0	Molecular replacement with MOLREP.	Alexei Vagin, Alexei Teplyakov	Acta Crystallogr D Biol Crystallogr	2010	20057045	Yes
2236	1359	1359.0	0.0	0.0	Immunological function of the thymus.	J F Miller	Lancet	1961	14474038	Yes
2237	1359	1359.0	0.0	0.0	Diversity in tropical rain forests and coral reefs.	J H Connell	Science	1978	17840770	Yes
2238	2718	1359.0	89.71	44.9	How good are my data and what is the resolution?	Philip R Evans, Garib N Murshudov	Acta Crystallogr D Biol Crystallogr	2013	23793146	Yes
2239	2718	1359.0	112.24	56.1	A new initiative on precision medicine.	Francis S Collins, Harold Varmus	N Engl J Med	2015	25635347	Yes
2240	2717	1358.5	84.9	42.5	Extended-connectivity fingerprints.	David Rogers, Mathew Hahn	J Chem Inf Model	2010	20426451	Yes
2241	1358	1358.0	51.87	51.9	Presidential address, 1980. Surprise!...Surprise?	E Donchin	Psychophysiology	1981	7280146	Yes
2242	1357	1357.0	25.9	25.9	The significance of responses of the genome to challenge.	B McClintock	Science	1984	15739260	No
2243	2713	1356.5	0.0	0.0	Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons.	A Dahlstroem, K Fuxe	Acta Physiol Scand Suppl	1964	14229500	Yes
2244	1356	1356.0	29.38	29.4	A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other.	Dale R Nyholt	Am J Hum Genet	2004	14997420	Yes
2245	1355	1355.0	32.91	32.9	Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule.	G von Heijne	J Mol Biol	1992	1593632	Yes
2246	1355	1355.0	90.22	90.2	The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system.	F C Ewald	Clin Orthop Relat Res	1989	2805502	Yes
2247	1355	1355.0	0.0	0.0	Origin of concatemeric T7 DNA.	J D Watson	Nat New Biol	1972	4507727	Yes
2248	1355	1355.0	49.19	49.2	Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living.	S Katz	J Am Geriatr Soc	1983	6418786	No
2249	1355	1355.0	60.08	60.1	Derivation and validation of a short-form oral health impact profile.	G D Slade	Community Dent Oral Epidemiol	1997	9332805	Yes
2250	4065	1355.0	0.0	0.0	Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation.	D D Sabatini, K Bensch, R J Barrnett	J Cell Biol	1963	13975866	Yes
2251	1355	1355.0	0.0	0.0	Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry.	Russell Lande	Evolution	1979	28568194	Yes
2252	2709	1354.5	62.85	31.4	NF-kappa B: ten years after.	P A Baeuerle, D Baltimore	Cell	1996	8858144	No
2253	4063	1354.3	88.33	29.4	Adjusting batch effects in microarray expression data using empirical Bayes methods.	W Evan Johnson, Cheng Li, Ariel Rabinovic	Biostatistics	2007	16632515	Yes
2254	2708	1354.0	0.0	0.0	A new scale of social desirability independent of psychopathology.	D P Crowne, D Marlowe	J Consult Psychol	1960	13813058	Yes
2255	10829	1353.6	273.39	34.2	Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain.	N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M Joliot	Neuroimage	2002	11771995	Yes
2256	4059	1353.0	191.3	63.8	Risk factors for falls among elderly persons living in the community.	M E Tinetti, M Speechley, S F Ginter	N Engl J Med	1988	3205267	Yes
2257	1353	1353.0	49.5	49.5	Quantitative methods in the review of epidemiologic literature.	S Greenland	Epidemiol Rev	1987	3678409	Yes
2258	1353	1353.0	30.92	30.9	Molecular basis of long-term plasticity underlying addiction.	E J Nestler	Nat Rev Neurosci	2001	11252991	No
2259	2703	1351.5	0.0	0.0	Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans.	D H Figurski, D R Helinski	Proc Natl Acad Sci U S A	1979	377280	Yes
2260	12160	1351.1	653.1	72.6	Cancer statistics in China, 2015.	Wanqing Chen, Rongshou Zheng, Peter D Baade, Siwei Zhang, Hongmei Zeng, Freddie Bray, Ahmedin Jemal, Xue Qin Yu, Jie He	CA Cancer J Clin	2016	26808342	Yes
2261	2701	1350.5	65.16	32.6	Inflammation, stress, and diabetes.	Kathryn E Wellen, Gökhan S Hotamisligil	J Clin Invest	2005	15864338	No
2262	1350	1350.0	70.57	70.6	The determinants of parenting: a process model.	J Belsky	Child Dev	1984	6705636	Yes
2263	1350	1350.0	42.16	42.2	The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat.	L W Swanson	Brain Res Bull	1982	6816390	Yes
2264	2699	1349.5	54.85	27.4	Short-term synaptic plasticity.	Robert S Zucker, Wade G Regehr	Annu Rev Physiol	2002	11826273	No
2265	4048	1349.3	180.48	60.2	The behaviour change wheel: a new method for characterising and designing behaviour change interventions.	Susan Michie, Maartje M van Stralen, Robert West	Implement Sci	2011	21513547	No
2266	2698	1349.0	95.53	47.8	A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels.	C M Tsai, C E Frasch	Anal Biochem	1982	6176137	Yes
2267	1348	1348.0	27.2	27.2	Dimerization of cell surface receptors in signal transduction.	C H Heldin	Cell	1995	7834741	No
2268	1348	1348.0	29.9	29.9	The ATP synthase--a splendid molecular machine.	P D Boyer	Annu Rev Biochem	1997	9242922	No
2269	1348	1348.0	34.72	34.7	Hemispheric asymmetry reduction in older adults: the HAROLD model.	Roberto Cabeza	Psychol Aging	2002	11931290	No
2270	1348	1348.0	25.9	25.9	Epithelial-mesenchymal transitions in development and pathologies.	Jean Paul Thiery	Curr Opin Cell Biol	2003	14644200	No
2271	1347	1347.0	0.0	0.0	Blood gas calculator.	J W Severinghaus	J Appl Physiol	1966	5912737	Yes
2272	2693	1346.5	0.0	0.0	The respiratory chain and oxidative phosphorylation.	B Chance, G R Williams	Adv Enzymol Relat Subj Biochem	1956	13313307	Yes
2273	1346	1346.0	30.43	30.4	DNA damage, aging, and cancer.	Jan H J Hoeijmakers	N Engl J Med	2009	19812404	No
2274	2692	1346.0	88.47	44.2	Modified RECIST (mRECIST) assessment for hepatocellular carcinoma.	Riccardo Lencioni, Josep M Llovet	Semin Liver Dis	2010	20175033	No
2275	1345	1345.0	0.0	0.0	Stereological principles for morphometry in electron microscopic cytology.	E R Weibel	Int Rev Cytol	1969	4899604	No
2276	1345	1345.0	0.0	0.0	The intraclass correlation coefficient as a measure of reliability.	J J Bartko	Psychol Rep	1966	5942109	Yes
2277	1345	1345.0	31.97	32.0	Regulation of differentiation of vascular smooth muscle cells.	G K Owens	Physiol Rev	1995	7624392	No
2278	2690	1345.0	140.38	70.2	MicroRNA therapeutics: towards a new era for the management of cancer and other diseases.	Rajesha Rupaimoole, Frank J Slack	Nat Rev Drug Discov	2017	28209991	No
2279	2688	1344.0	0.0	0.0	Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease.	G J Miller, N E Miller	Lancet	1975	46338	Yes
2280	1344	1344.0	64.15	64.2	Molecular pathology of schizophrenia: more than one disease process?	T J Crow	Br Med J	1980	6101544	No
2281	2688	1344.0	79.9	40.0	Mediation in experimental and nonexperimental studies: new procedures and recommendations.	Patrick E Shrout, Niall Bolger	Psychol Methods	2002	12530702	Yes
2282	1344	1344.0	0.0	0.0	A modified procedure for lead staining of thin sections.	G Millonig	J Biophys Biochem Cytol	1961	14474176	Yes
2283	1344	1344.0	34.53	34.5	Wound healing and its impairment in the diabetic foot.	Vincent Falanga	Lancet	2005	16291068	No
2284	1343	1343.0	41.34	41.3	Neurotransmitters and neuromodulators in the basal ganglia.	A M Graybiel	Trends Neurosci	1990	1695398	No
2285	1343	1343.0	0.0	0.0	Hippocampal electrical activity and voluntary movement in the rat.	C H Vanderwolf	Electroencephalogr Clin Neurophysiol	1969	4183562	Yes
2286	1343	1343.0	43.35	43.4	History of the Rochester Epidemiology Project.	L J Melton	Mayo Clin Proc	1996	8594285	No
2287	1343	1343.0	29.73	29.7	Target-oriented and diversity-oriented organic synthesis in drug discovery.	S L Schreiber	Science	2000	10720315	No
2288	4029	1343.0	86.59	28.9	Multidrug resistance in cancer: role of ATP-dependent transporters.	Michael M Gottesman, Tito Fojo, Susan E Bates	Nat Rev Cancer	2002	11902585	No
2289	1343	1343.0	24.23	24.2	The snail superfamily of zinc-finger transcription factors.	M Angela Nieto	Nat Rev Mol Cell Biol	2002	11994736	No
2290	2686	1343.0	69.33	34.7	A globally coherent fingerprint of climate change impacts across natural systems.	Camille Parmesan, Gary Yohe	Nature	2003	12511946	Yes
2291	1342	1342.0	23.49	23.5	The economics of ribosome biosynthesis in yeast.	J R Warner	Trends Biochem Sci	1999	10542411	No
2292	2683	1341.5	0.0	0.0	Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes.	E Engvall, P Perlmann	J Immunol	1972	4113792	Yes
2293	1341	1341.0	35.86	35.9	Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies.	S L Friedman	N Engl J Med	1993	8502273	No
2294	1341	1341.0	22.39	22.4	Cancer. Addiction to oncogenes--the Achilles heal of cancer.	I Bernard Weinstein	Science	2002	12098689	No
2295	5363	1340.8	124.97	31.2	Quantitative monitoring of gene expression patterns with a complementary DNA microarray.	M Schena, D Shalon, R W Davis, P O Brown	Science	1995	7569999	Yes
2296	2681	1340.5	0.0	0.0	Further improvements in the plaque technique for detecting single antibody-forming cells.	A J Cunningham, A Szenberg	Immunology	1968	5653817	Yes
2297	2681	1340.5	79.12	39.6	The Measurement Of Selection On Correlated Characters.	Russell Lande, Stevan J Arnold	Evolution	1983	28556011	Yes
2298	1340	1340.0	0.0	0.0	Renin-angiotensin system: biochemistry and mechanisms of action.	M J Peach	Physiol Rev	1977	191856	No
2299	2680	1340.0	0.0	0.0	Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.	G Blobel, B Dobberstein	J Cell Biol	1975	811671	Yes
2300	1340	1340.0	48.57	48.6	The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria.	A Raine	Schizophr Bull	1991	1805349	Yes
2301	2680	1340.0	86.85	43.4	The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.	W R Gibb, A J Lees	J Neurol Neurosurg Psychiatry	1988	2841426	No
2302	4020	1340.0	97.22	32.4	Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies.	Daniel Falush, Matthew Stephens, Jonathan K Pritchard	Genetics	2003	12930761	Yes
2303	2679	1339.5	55.21	27.6	Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.	J M Kyriakis, J Avruch	Physiol Rev	2001	11274345	No
2304	8036	1339.3	210.25	35.0	Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.	Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur Wheeler	N Engl J Med	2000	10793162	Yes
2305	1339	1339.0	0.0	0.0	A new readability yardstick.	R Flesch	J Appl Psychol	1948	18867058	Yes
2306	1338	1338.0	24.29	24.3	Chromatin modification and epigenetic reprogramming in mammalian development.	En Li	Nat Rev Genet	2002	12209141	No
2307	2674	1337.0	86.81	43.4	LigPlot+: multiple ligand-protein interaction diagrams for drug discovery.	Roman A Laskowski, Mark B Swindells	J Chem Inf Model	2011	21919503	Yes
2308	1337	1337.0	40.69	40.7	Mitochondria and cancer.	Douglas C Wallace	Nat Rev Cancer	2012	23001348	No
2309	1336	1336.0	33.74	33.7	A molecular view of microbial diversity and the biosphere.	N R Pace	Science	1997	9115194	No
2310	4008	1336.0	82.24	27.4	The versatility and universality of calcium signalling.	M J Berridge, P Lipp, M D Bootman	Nat Rev Mol Cell Biol	2000	11413485	No
2311	4008	1336.0	137.31	45.8	Global estimates of the prevalence of diabetes for 2010 and 2030.	J E Shaw, R A Sicree, P Z Zimmet	Diabetes Res Clin Pract	2010	19896746	Yes
2312	2670	1335.0	0.0	0.0	A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants.	R L Juliano, V Ling	Biochim Biophys Acta	1976	990323	Yes
2313	1335	1335.0	40.17	40.2	Energy contributions of volatile fatty acids from the gastrointestinal tract in various species.	E N Bergman	Physiol Rev	1990	2181501	No
2314	1335	1335.0	38.46	38.5	Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation.	P Willner	Psychopharmacology (Berl)	1997	9452163	No
2315	1335	1335.0	55.31	55.3	Modeling Development and Disease with Organoids.	Hans Clevers	Cell	2016	27315476	No
2316	2669	1334.5	86.46	43.2	Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art.	Johan W S Vlaeyen, Steven J Linton	Pain	2000	10781906	No
2317	1334	1334.0	47.39	47.4	Neuropeptide Y: complete amino acid sequence of the brain peptide.	K Tatemoto	Proc Natl Acad Sci U S A	1982	6957876	Yes
2318	1334	1334.0	26.03	26.0	Chromosomal translocations in human cancer.	T H Rabbitts	Nature	1994	7969446	No
2319	1334	1334.0	0.0	0.0	Cellular resistance to infection.	G B Mackaness	J Exp Med	1962	14467923	Yes
2320	1334	1334.0	33.62	33.6	N-heterocyclic carbenes: a new concept in organometallic catalysis.	Wolfgang A Herrmann	Angew Chem Int Ed Engl	2002	19750753	Yes
2321	2667	1333.5	61.43	30.7	The RXR heterodimers and orphan receptors.	D J Mangelsdorf, R M Evans	Cell	1995	8521508	No
2322	1333	1333.0	35.09	35.1	The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure.	K Kuwajima	Proteins	1989	2695928	No
2323	2666	1333.0	111.05	55.5	Natural products as sources of new drugs over the 30 years from 1981 to 2010.	David J Newman, Gordon M Cragg	J Nat Prod	2012	22316239	No
2324	2665	1332.5	55.13	27.6	Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.	P J Southern, P Berg	J Mol Appl Genet	1982	6286831	Yes
2325	1332	1332.0	42.17	42.2	The phenomenon of the acute phase response.	I Kushner	Ann N Y Acad Sci	1982	7046585	No
2326	1332	1332.0	41.58	41.6	The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases.	Artemis P Simopoulos	Exp Biol Med (Maywood)	2008	18408140	No
2327	5327	1331.8	128.67	32.2	The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling.	Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten Schwede	Bioinformatics	2006	16301204	Yes
2328	5327	1331.8	139.38	34.8	Microbial ecology: human gut microbes associated with obesity.	Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I Gordon	Nature	2006	17183309	Yes
2329	1331	1331.0	0.0	0.0	Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System.	K Fuxe	Acta Physiol Scand Suppl	1965	14319769	Yes
2330	2662	1331.0	76.12	38.1	miRBase: integrating microRNA annotation and deep-sequencing data.	Ana Kozomara, Sam Griffiths-Jones	Nucleic Acids Res	2011	21037258	Yes
2331	1330	1330.0	35.55	35.5	Fibronectin and its receptors.	E Ruoslahti	Annu Rev Biochem	1988	2972252	No
2332	1330	1330.0	35.27	35.3	Genetic consequences of climatic oscillations in the Quaternary.	G M Hewitt	Philos Trans R Soc Lond B Biol Sci	2004	15101575	No
2333	1330	1330.0	41.92	41.9	Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations.	Chao-Jun Li	Acc Chem Res	2009	19220064	Yes
2334	2660	1330.0	58.23	29.1	NMR View: A computer program for the visualization and analysis of NMR data.	B A Johnson, R A Blevins	J Biomol NMR	1994	22911360	Yes
2335	6646	1329.2	249.43	49.9	Evidence based medicine: what it is and what it isn't.	D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S Richardson	BMJ	1996	8555924	No
2336	1329	1329.0	28.08	28.1	Stability and flexibility of epigenetic gene regulation in mammalian development.	Wolf Reik	Nature	2007	17522676	No
2337	1328	1328.0	42.36	42.4	Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia.	A A Grace	Neuroscience	1991	1676137	No
2338	1328	1328.0	42.17	42.2	Glutathione metabolism and its selective modification.	A Meister	J Biol Chem	1988	3053703	No
2339	1328	1328.0	49.12	49.1	Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models.	T Florian Jaeger	J Mem Lang	2008	19884961	Yes
2340	3983	1327.7	107.87	36.0	TCS: a computer program to estimate gene genealogies.	M Clement, D Posada, K A Crandall	Mol Ecol	2000	11050560	Yes
2341	5310	1327.5	0.0	0.0	Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.	D W Cleveland, S G Fischer, M W Kirschner, U K Laemmli	J Biol Chem	1977	320200	Yes
2342	1327	1327.0	60.27	60.3	Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters.	P de Leva	J Biomech	1996	8872282	Yes
2343	1327	1327.0	35.7	35.7	Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications.	P Lips	Endocr Rev	2001	11493580	No
2344	1327	1327.0	34.62	34.6	The cancer stem cell: premises, promises and challenges.	Hans Clevers	Nat Med	2011	21386835	No
2345	1326	1326.0	0.0	0.0	Letter: Grading of angina pectoris.	L Campeau	Circulation	1976	947585	Yes
2346	1326	1326.0	39.52	39.5	Depression in late life: review and commentary.	Dan G Blazer	J Gerontol A Biol Sci Med Sci	2003	12634292	No
2347	2651	1325.5	78.78	39.4	CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure.	Mattias Jakobsson, Noah A Rosenberg	Bioinformatics	2007	17485429	Yes
2348	6626	1325.2	196.11	39.2	Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication.	Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E Walters	Arch Gen Psychiatry	2005	15939839	Yes
2349	2650	1325.0	0.0	0.0	Immunization of dissociated spleen cell cultures from normal mice.	R I Mishell, R W Dutton	J Exp Med	1967	6034749	Yes
2350	2649	1324.5	60.6	30.3	Integrins and signal transduction pathways: the road taken.	E A Clark, J S Brugge	Science	1995	7716514	No
2351	2649	1324.5	60.56	30.3	Disruption of epithelial cell-matrix interactions induces apoptosis.	S M Frisch, H Francis	J Cell Biol	1994	8106557	Yes
2352	5297	1324.2	213.63	53.4	Bayesian phylogenetics with BEAUti and the BEAST 1.7.	Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew Rambaut	Mol Biol Evol	2012	22367748	Yes
2353	2648	1324.0	105.23	52.6	Assessment of eating disorders: interview or self-report questionnaire?	C G Fairburn, S J Beglin	Int J Eat Disord	1994	7866415	Yes
2354	1324	1324.0	34.69	34.7	The human orbitofrontal cortex: linking reward to hedonic experience.	Morten L Kringelbach	Nat Rev Neurosci	2005	16136173	No
2355	1324	1324.0	39.93	39.9	Interleukin-1 in the pathogenesis and treatment of inflammatory diseases.	Charles A Dinarello	Blood	2011	21304099	No
2356	2647	1323.5	57.29	28.6	LTP and LTD: an embarrassment of riches.	Robert C Malenka, Mark F Bear	Neuron	2004	15450156	No
2357	1323	1323.0	0.0	0.0	A simple ultraviolet spectrophotometric method for the determination of protein.	W J Waddell	J Lab Clin Med	1956	13346201	Yes
2358	1322	1322.0	45.18	45.2	Functional organization of central pathways regulating the cardiovascular system.	R A Dampney	Physiol Rev	1994	8171117	No
2359	1322	1322.0	41.86	41.9	Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data.	Thomas Heberer	Toxicol Lett	2002	11988354	Yes
2360	2643	1321.5	66.36	33.2	Powering the planet: chemical challenges in solar energy utilization.	Nathan S Lewis, Daniel G Nocera	Proc Natl Acad Sci U S A	2006	17043226	Yes
2361	1321	1321.0	30.94	30.9	Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?	Rui Wang	FASEB J	2002	12409322	Yes
2362	1320	1320.0	28.41	28.4	The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats.	G B Morin	Cell	1989	2805070	Yes
2363	1320	1320.0	35.4	35.4	Diagnosis of osteoporosis and assessment of fracture risk.	John A Kanis	Lancet	2002	12057569	No
2364	1319	1319.0	29.85	29.9	Functions of the neurotrophins during nervous system development: what the knockouts are teaching us.	W D Snider	Cell	1994	8205613	No
2365	2638	1319.0	59.81	29.9	A comparison of bayesian methods for haplotype reconstruction from population genotype data.	Matthew Stephens, Peter Donnelly	Am J Hum Genet	2003	14574645	Yes
2366	1319	1319.0	23.14	23.1	Protein modification by SUMO.	Erica S Johnson	Annu Rev Biochem	2004	15189146	No
2367	3957	1319.0	82.51	27.5	Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM).	Michael J Rust, Mark Bates, Xiaowei Zhuang	Nat Methods	2006	16896339	Yes
2368	2637	1318.5	72.67	36.3	Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies.	Robert E W Hancock, Hans-Georg Sahl	Nat Biotechnol	2006	17160061	No
2369	2636	1318.0	0.0	0.0	Glutathione peroxidase activity in selenium-deficient rat liver.	R A Lawrence, R F Burk	Biochem Biophys Res Commun	1976	971321	Yes
2370	1318	1318.0	0.0	0.0	Stimulus-secretion coupling: the concept and clues from chromaffin and other cells.	W W Douglas	Br J Pharmacol	1968	4882190	No
2371	1318	1318.0	31.64	31.6	Apoptosis in cancer therapy: crossing the threshold.	D E Fisher	Cell	1994	8069905	No
2372	1318	1318.0	0.0	0.0	A quantitative immunochemical measure of the primary interaction between I BSA and antibody.	R S Farr	J Infect Dis	1958	13611294	Yes
2373	1317	1317.0	48.49	48.5	The structure of beta-lactamases.	R P Ambler	Philos Trans R Soc Lond B Biol Sci	1980	6109327	Yes
2374	3950	1316.7	98.19	32.7	The p53 tumour suppressor gene.	A J Levine, J Momand, C A Finlay	Nature	1991	2046748	No
2375	1316	1316.0	23.26	23.3	Regulatory T cells: key controllers of immunologic self-tolerance.	S Sakaguchi	Cell	2000	10850488	No
2376	3948	1316.0	78.85	26.3	The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.	Fabio Martinon, Kimberly Burns, Jürg Tschopp	Mol Cell	2002	12191486	Yes
2377	2632	1316.0	110.49	55.2	Methods for the thematic synthesis of qualitative research in systematic reviews.	James Thomas, Angela Harden	BMC Med Res Methodol	2008	18616818	Yes
2378	1315	1315.0	50.68	50.7	Free-radical mechanisms in tissue injury.	T F Slater	Biochem J	1984	6383353	No
2379	2629	1314.5	66.45	33.2	The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes.	Daniel J Drucker, Michael A Nauck	Lancet	2006	17098089	No
2380	1314	1314.0	28.01	28.0	Double identity for proteins of the Bcl-2 family.	J C Reed	Nature	1997	9194558	No
2381	1314	1314.0	27.26	27.3	The many faces of macrophage activation.	David M Mosser	J Leukoc Biol	2003	12554797	No
2382	1313	1313.0	33.55	33.5	Thioredoxin and glutaredoxin systems.	A Holmgren	J Biol Chem	1989	2668278	No
2383	3939	1313.0	116.79	38.9	Dose translation from animal to human studies revisited.	Shannon Reagan-Shaw, Minakshi Nihal, Nihal Ahmad	FASEB J	2008	17942826	Yes
2384	2626	1313.0	70.87	35.4	Alternative activation of macrophages: mechanism and functions.	Siamon Gordon, Fernando O Martinez	Immunity	2010	20510870	No
2385	3938	1312.7	97.91	32.6	Wnt/beta-catenin signaling: components, mechanisms, and diseases.	Bryan T MacDonald, Keiko Tamai, Xi He	Dev Cell	2009	19619488	No
2386	1312	1312.0	56.43	56.4	Working memory: theories, models, and controversies.	Alan Baddeley	Annu Rev Psychol	2012	21961947	No
2387	2623	1311.5	65.59	32.8	Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering.	M P Lutolf, J A Hubbell	Nat Biotechnol	2005	15637621	No
2388	1311	1311.0	0.0	0.0	The origin of the genetic code.	F H Crick	J Mol Biol	1968	4887876	Yes
2389	6554	1310.8	162.79	32.6	Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies.	Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory Collins	Lancet	2002	12493255	Yes
2390	3932	1310.7	89.14	29.7	OrthoMCL: identification of ortholog groups for eukaryotic genomes.	Li Li, Christian J Stoeckert, David S Roos	Genome Res	2003	12952885	Yes
2391	1310	1310.0	36.96	37.0	The matrix-degrading metalloproteinases.	L M Matrisian	Bioessays	1992	1445287	No
2392	2620	1310.0	52.46	26.2	Prediction of complete gene structures in human genomic DNA.	C Burge, S Karlin	J Mol Biol	1997	9149143	Yes
2393	1310	1310.0	28.31	28.3	HIF-1: mediator of physiological and pathophysiological responses to hypoxia.	G L Semenza	J Appl Physiol (1985)	2000	10749844	No
2394	1310	1310.0	0.0	0.0	Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples.	P F Scholander	J Biol Chem	1947	20281644	Yes
2395	1310	1310.0	40.44	40.4	Breakthrough of the year 2013. Cancer immunotherapy.	Jennifer Couzin-Frankel	Science	2013	24357284	No
2396	2617	1308.5	75.3	37.6	Epidemiology of invasive candidiasis: a persistent public health problem.	M A Pfaller, D J Diekema	Clin Microbiol Rev	2007	17223626	No
2397	2614	1307.0	59.7	29.9	Supercoil sequencing: a fast and simple method for sequencing plasmid DNA.	E Y Chen, P H Seeburg	DNA	1985	3996185	Yes
2398	1307	1307.0	34.26	34.3	The aryl hydrocarbon receptor complex.	O Hankinson	Annu Rev Pharmacol Toxicol	1995	7598497	No
2399	2614	1307.0	79.46	39.7	Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India.	D Filmer, L H Pritchett	Demography	2001	11227840	Yes
2400	5226	1306.5	125.58	31.4	Improved prediction of signal peptides: SignalP 3.0.	Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren Brunak	J Mol Biol	2004	15223320	Yes
2401	2612	1306.0	0.0	0.0	Functions of lysosomes.	C De Duve, R Wattiaux	Annu Rev Physiol	1966	5322983	No
2402	1305	1305.0	23.04	23.0	Clonal selection and learning in the antibody system.	K Rajewsky	Nature	1996	8657279	No
2403	1305	1305.0	36.13	36.1	Atopic dermatitis.	Thomas Bieber	N Engl J Med	2008	18385500	Yes
2404	1305	1305.0	0.0	0.0	The antidiuretic hormone and the factors which determine its release.	E B Verney	Proc R Soc Lond B Biol Sci	1947	18918876	Yes
2405	2608	1304.0	0.0	0.0	A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival.	B G Durie, S E Salmon	Cancer	1975	1182674	Yes
2406	1304	1304.0	28.42	28.4	Codon usage and tRNA content in unicellular and multicellular organisms.	T Ikemura	Mol Biol Evol	1985	3916708	No
2407	1304	1304.0	38.57	38.6	Osteoblast adhesion on biomaterials.	K Anselme	Biomaterials	2000	10711964	No
2408	1304	1304.0	35.52	35.5	Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects.	E B Hunziker	Osteoarthritis Cartilage	2002	12056848	No
2409	1304	1304.0	0.0	0.0	The critical incident technique.	J C Flanagan	Psychol Bull	1954	13177800	Yes
2410	2607	1303.5	66.26	33.1	Myocardial reperfusion injury.	Derek M Yellon, Derek J Hausenloy	N Engl J Med	2007	17855673	No
2411	3910	1303.3	89.22	29.7	Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides.	Christian W Tornøe, Caspar Christensen, Morten Meldal	J Org Chem	2002	11975567	Yes
2412	7819	1303.2	198.74	33.1	A default mode of brain function.	M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L Shulman	Proc Natl Acad Sci U S A	2001	11209064	Yes
2413	1303	1303.0	38.29	38.3	The fetal and infant origins of adult disease.	D J Barker	BMJ	1990	2252919	No
2414	1303	1303.0	24.41	24.4	Antigen-specific interaction between T and B cells.	A Lanzavecchia	Nature	1985	3157869	Yes
2415	2606	1303.0	65.98	33.0	The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity.	Clay B Holroyd, Michael G H Coles	Psychol Rev	2002	12374324	Yes
2416	1303	1303.0	37.76	37.8	The Hospital Anxiety And Depression Scale.	R Philip Snaith	Health Qual Life Outcomes	2003	12914662	Yes
2417	2604	1302.0	55.55	27.8	Liver regeneration.	G K Michalopoulos, M C DeFrances	Science	1997	9082986	No
2418	1302	1302.0	25.27	25.3	microRNAs: tiny regulators with great potential.	V Ambros	Cell	2001	11779458	No
2419	1301	1301.0	23.82	23.8	c-Myc target genes involved in cell growth, apoptosis, and metabolism.	C V Dang	Mol Cell Biol	1999	9858526	No
2420	1300	1300.0	0.0	0.0	The biologic clock: the mitochondria?	D Harman	J Am Geriatr Soc	1972	5016631	Yes
2421	1300	1300.0	38.81	38.8	Circuitry and functional aspects of the insular lobe in primates including humans.	J R Augustine	Brain Res Brain Res Rev	1996	8957561	No
2422	1299	1299.0	33.88	33.9	Supported membranes: scientific and practical applications.	E Sackmann	Science	1996	8539599	No
2423	1299	1299.0	23.85	23.9	CD95's deadly mission in the immune system.	P H Krammer	Nature	2000	11048730	No
2424	1299	1299.0	28.94	28.9	Diarylethenes for Memories and Switches.	Masahiro Irie	Chem Rev	2000	11777416	Yes
2425	1299	1299.0	0.0	0.0	On the psychophysical law.	S S Stevens	Psychol Rev	1957	13441853	Yes
2426	2597	1298.5	48.26	24.1	New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites.	R D Gietz, A Sugino	Gene	1988	3073106	Yes
2427	1298	1298.0	48.31	48.3	The life and times of the Enterococcus.	B E Murray	Clin Microbiol Rev	1990	2404568	No
2428	1298	1298.0	31.21	31.2	Receptors for epidermal growth factor and other polypeptide mitogens.	G Carpenter	Annu Rev Biochem	1987	3039909	No
2429	1298	1298.0	34.21	34.2	Phylogenies from molecular sequences: inference and reliability.	J Felsenstein	Annu Rev Genet	1988	3071258	No
2430	1298	1298.0	0.0	0.0	The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C.	R G Khalifah	J Biol Chem	1971	4994926	Yes
2431	2595	1297.5	91.76	45.9	Total energy intake: implications for epidemiologic analyses.	W Willett, M J Stampfer	Am J Epidemiol	1986	3521261	No
2432	2595	1297.5	80.62	40.3	An estimate of the worldwide prevalence and disability associated with osteoporotic fractures.	O Johnell, J A Kanis	Osteoporos Int	2006	16983459	Yes
2433	9080	1297.1	372.36	53.2	Development and validation of a geriatric depression screening scale: a preliminary report.	J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O Leirer	J Psychiatr Res	1982	7183759	Yes
2434	2594	1297.0	0.0	0.0	Epidermal growth factor.	G Carpenter, S Cohen	Annu Rev Biochem	1979	382984	No
2435	2594	1297.0	0.0	0.0	The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites.	J Shine, L Dalgarno	Proc Natl Acad Sci U S A	1974	4598299	Yes
2436	1297	1297.0	35.89	35.9	The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.	R G Gerrity	Am J Pathol	1981	7234961	Yes
2437	1297	1297.0	33.26	33.3	Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders.	R M Sapolsky	Arch Gen Psychiatry	2000	11015810	No
2438	2594	1297.0	70.54	35.3	Antibiotic resistance of bacteria in biofilms.	P S Stewart, J W Costerton	Lancet	2001	11463434	No
2439	3891	1297.0	114.19	38.1	A rapid bootstrap algorithm for the RAxML Web servers.	Alexandros Stamatakis, Paul Hoover, Jacques Rougemont	Syst Biol	2008	18853362	Yes
2440	2593	1296.5	117.5	58.8	3D bioprinting of tissues and organs.	Sean V Murphy, Anthony Atala	Nat Biotechnol	2014	25093879	Yes
2441	2593	1296.5	73.31	36.7	The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin.	W L Jorgensen, J Tirado-Rives	J Am Chem Soc	1988	27557051	Yes
2442	3889	1296.3	83.77	27.9	A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.	R Medzhitov, P Preston-Hurlburt, C A Janeway	Nature	1997	9237759	Yes
2443	2592	1296.0	61.71	30.9	Production of single-stranded plasmid DNA.	J Vieira, J Messing	Methods Enzymol	1987	3323803	Yes
2444	1296	1296.0	30.85	30.9	Huntington's disease.	Francis O Walker	Lancet	2007	17240289	No
2445	2590	1295.0	53.6	26.8	Regulated portals of entry into the cell.	Sean D Conner, Sandra L Schmid	Nature	2003	12621426	No
2446	2589	1294.5	43.67	21.8	Genetic transformation of Drosophila with transposable element vectors.	G M Rubin, A C Spradling	Science	1982	6289436	Yes
2447	2587	1293.5	67.85	33.9	Morris water maze: procedures for assessing spatial and related forms of learning and memory.	Charles V Vorhees, Michael T Williams	Nat Protoc	2006	17406317	Yes
2448	1293	1293.0	44.58	44.6	Carnitine--metabolism and functions.	J Bremer	Physiol Rev	1983	6361812	No
2449	6461	1292.2	0.0	0.0	Transection of the oesophagus for bleeding oesophageal varices.	R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R Williams	Br J Surg	1973	4541913	Yes
2450	1292	1292.0	33.87	33.9	Mitochondrial fusion and fission in cell life and death.	Benedikt Westermann	Nat Rev Mol Cell Biol	2010	21102612	No
2451	14208	1291.6	389.0	35.4	The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data.	Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristo	Genome Res	2010	20644199	Yes
2452	2583	1291.5	46.33	23.2	Rab proteins as membrane organizers.	M Zerial, H McBride	Nat Rev Mol Cell Biol	2001	11252952	No
2453	3872	1290.7	132.88	44.3	Factor structure of the Barratt impulsiveness scale.	J H Patton, M S Stanford, E S Barratt	J Clin Psychol	1995	8778124	Yes
2454	2581	1290.5	76.69	38.3	Physiological time-series analysis using approximate entropy and sample entropy.	J S Richman, J R Moorman	Am J Physiol Heart Circ Physiol	2000	10843903	Yes
2455	1290	1290.0	0.0	0.0	Disconnexion syndromes in animals and man. I.	N Geschwind	Brain	1965	5318481	No
2456	1289	1289.0	30.54	30.5	Lymphokine production by human T cells in disease states.	S Romagnani	Annu Rev Immunol	1994	8011282	No
2457	2578	1289.0	64.08	32.0	Regulation mechanisms and signaling pathways of autophagy.	Congcong He, Daniel J Klionsky	Annu Rev Genet	2009	19653858	No
2458	2577	1288.5	62.11	31.1	Multipoint quantitative-trait linkage analysis in general pedigrees.	L Almasy, J Blangero	Am J Hum Genet	1998	9545414	Yes
2459	1288	1288.0	0.0	0.0	A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon.	A M Olovnikov	J Theor Biol	1973	4754905	Yes
2460	2576	1288.0	56.26	28.1	Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information.	M Zuker, P Stiegler	Nucleic Acids Res	1981	6163133	Yes
2461	1288	1288.0	28.85	28.9	Physiological and molecular basis of thyroid hormone action.	P M Yen	Physiol Rev	2001	11427693	No
2462	1288	1288.0	29.0	29.0	Transcriptional control of adipocyte formation.	Stephen R Farmer	Cell Metab	2006	17011499	No
2463	2575	1287.5	0.0	0.0	Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens.	J A Ledbetter, L A Herzenberg	Immunol Rev	1979	398327	No
2464	1287	1287.0	38.95	39.0	Classification of chronic viral hepatitis: a need for reassessment.	P J Scheuer	J Hepatol	1991	1808228	No
2465	1287	1287.0	0.0	0.0	Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action.	J H Luft	Anat Rec	1971	4108333	Yes
2466	1287	1287.0	30.98	31.0	Papillomavirus infections--a major cause of human cancers.	H zur Hausen	Biochim Biophys Acta	1996	8876633	No
2467	1287	1287.0	30.18	30.2	Nonaqueous liquid electrolytes for lithium-based rechargeable batteries.	Kang Xu	Chem Rev	2004	15669157	Yes
2468	3860	1286.7	90.22	30.1	Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?	Witold Filipowicz, Suvendra N Bhattacharyya, Nahum Sonenberg	Nat Rev Genet	2008	18197166	No
2469	2572	1286.0	0.0	0.0	Regulatory sequences involved in the promotion and termination of RNA transcription.	M Rosenberg, D Court	Annu Rev Genet	1979	94251	No
2470	1286	1286.0	41.99	42.0	An application of prefrontal cortex function theory to cognitive aging.	R L West	Psychol Bull	1996	8831298	No
2471	1286	1286.0	25.22	25.2	Mechanisms of caspase activation and inhibition during apoptosis.	Yigong Shi	Mol Cell	2002	11931755	No
2472	1286	1286.0	34.11	34.1	Microbial influences in inflammatory bowel diseases.	R Balfour Sartor	Gastroenterology	2008	18242222	No
2473	1286	1286.0	28.82	28.8	Mechanisms of foxp3+ T regulatory cell-mediated suppression.	Ethan M Shevach	Immunity	2009	19464986	No
2474	3856	1285.3	100.71	33.6	Cognitive and emotional influences in anterior cingulate cortex.	Bush, Luu, Posner	Trends Cogn Sci	2000	10827444	Yes
2475	1285	1285.0	0.0	0.0	Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents.	A Böyum	Scand J Clin Lab Invest Suppl	1968	4179066	Yes
2476	1285	1285.0	23.24	23.2	SUMO: a history of modification.	Ronald T Hay	Mol Cell	2005	15808504	No
2477	1285	1285.0	43.48	43.5	The role of autophagy in neurodegenerative disease.	Ralph A Nixon	Nat Med	2013	23921753	No
2478	2568	1284.0	0.0	0.0	Prediction of the secondary structure of proteins from their amino acid sequence.	P Y Chou, G D Fasman	Adv Enzymol Relat Areas Mol Biol	1978	364941	No
2479	1284	1284.0	0.0	0.0	Cardiovascular and renal actions of dopamine: potential clinical applications.	L I Goldberg	Pharmacol Rev	1972	4554480	No
2480	2568	1284.0	66.46	33.2	Therapeutic potential of resveratrol: the in vivo evidence.	Joseph A Baur, David A Sinclair	Nat Rev Drug Discov	2006	16732220	No
2481	2565	1282.5	60.42	30.2	Emerging roles of caspase-3 in apoptosis.	A G Porter, R U Jänicke	Cell Death Differ	1999	10200555	No
2482	2565	1282.5	64.09	32.0	Microglia: active sensor and versatile effector cells in the normal and pathologic brain.	Uwe-Karsten Hanisch, Helmut Kettenmann	Nat Neurosci	2007	17965659	No
2483	1282	1282.0	38.9	38.9	Diversity and ubiquity of K channels.	B Rudy	Neuroscience	1988	2457185	No
2484	2564	1282.0	58.55	29.3	Cancer stem cells in solid tumours: accumulating evidence and unresolved questions.	Jane E Visvader, Geoffrey J Lindeman	Nat Rev Cancer	2008	18784658	No
2485	1281	1281.0	39.6	39.6	Somatostatin.	S Reichlin	N Engl J Med	1983	6139753	No
2486	2561	1280.5	66.76	33.4	Apoptosis, oncosis, and necrosis. An overview of cell death.	G Majno, I Joris	Am J Pathol	1995	7856735	No
2487	1280	1280.0	53.08	53.1	Error in medicine.	L L Leape	JAMA	1994	7503827	Yes
2488	1280	1280.0	35.34	35.3	Adult mesenchymal stem cells for tissue engineering versus regenerative medicine.	Arnold I Caplan	J Cell Physiol	2007	17620285	No
2489	1280	1280.0	0.0	0.0	The generalisation of student's problems when several different population variances are involved.	B L Welch	Biometrika	1947	20287819	Yes
2490	1279	1279.0	0.0	0.0	Electrophoretic separation of plasma lipoproteins in agarose gel.	R P Noble	J Lipid Res	1968	4176473	Yes
2491	1279	1279.0	0.0	0.0	Agammaglobulinemia.	O C Bruton	Pediatrics	1952	14929630	Yes
2492	1279	1279.0	37.43	37.4	Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.	Felix Kratz	J Control Release	2008	18582981	No
2493	2556	1278.0	0.0	0.0	Establishment and characterization of a human histiocytic lymphoma cell line (U-937).	C Sundström, K Nilsson	Int J Cancer	1976	178611	Yes
2494	1278	1278.0	29.12	29.1	Chemistry and biology of the immunophilins and their immunosuppressive ligands.	S L Schreiber	Science	1991	1702904	No
2495	1278	1278.0	68.76	68.8	Psychosocial resilience and protective mechanisms.	Michael Rutter	Am J Orthopsychiatry	1987	3303954	No
2496	2556	1278.0	55.74	27.9	Mitochondrial control of cell death.	G Kroemer, J C Reed	Nat Med	2000	10802706	No
2497	1277	1277.0	27.9	27.9	Prediction of protein cellular attributes using pseudo-amino acid composition.	K C Chou	Proteins	2001	11288174	Yes
2498	1277	1277.0	0.0	0.0	The anterior approach for removal of ruptured cervical disks.	R B Cloward	J Neurosurg	1958	13599052	Yes
2499	6383	1276.6	0.0	0.0	Enzymatic determination of total serum cholesterol.	C C Allain, L S Poon, C S Chan, W Richmond, P C Fu	Clin Chem	1974	4818200	Yes
2500	5106	1276.5	115.28	28.8	Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.	Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J Thun	N Engl J Med	2003	12711737	Yes
2501	3828	1276.0	96.51	32.2	LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions.	A C Wallace, R A Laskowski, J M Thornton	Protein Eng	1995	7630882	Yes
2502	2551	1275.5	0.0	0.0	Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty.	J M Tanner, R H Whitehouse	Arch Dis Child	1976	952550	Yes
2503	3825	1275.0	136.11	45.4	A new method for off-line removal of ocular artifact.	G Gratton, M G Coles, E Donchin	Electroencephalogr Clin Neurophysiol	1983	6187540	Yes
2504	1275	1275.0	62.04	62.0	The clinical application of the biopsychosocial model.	G L Engel	Am J Psychiatry	1980	7369396	Yes
2505	1274	1274.0	35.69	35.7	The pollution of the marine environment by plastic debris: a review.	José G B Derraik	Mar Pollut Bull	2002	12405208	No
2506	1273	1273.0	44.14	44.1	The theoretical bases of indirect calorimetry: a review.	E Ferrannini	Metabolism	1988	3278194	No
2507	1273	1273.0	43.14	43.1	Synopsis of some recent tactical application of bioisosteres in drug design.	Nicholas A Meanwell	J Med Chem	2011	21413808	Yes
2508	1272	1272.0	0.0	0.0	Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology.	W D Hamilton	Science	1967	6021675	Yes
2509	1272	1272.0	35.06	35.1	Polycystic ovary syndrome.	David A Ehrmann	N Engl J Med	2005	15788499	No
2510	1272	1272.0	0.0	0.0	Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism.	H M Kalckar	J Biol Chem	1947	20285041	Yes
2511	1272	1272.0	0.0	0.0	Limitations of the application of fourfold table analysis to hospital data.	J Berkson	Biometrics	1946	21001024	Yes
2512	1271	1271.0	25.79	25.8	Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy.	R H Schwartz	Cell	1992	1335362	No
2513	1271	1271.0	46.36	46.4	Substance P.	B Pernow	Pharmacol Rev	1983	6196797	No
2514	1271	1271.0	29.89	29.9	The path to ubiquitous and low-cost organic electronic appliances on plastic.	Stephen R Forrest	Nature	2004	15118718	Yes
2515	1271	1271.0	0.0	0.0	On the local reactions of the arterial wall to changes of internal pressure.	W M Bayliss	J Physiol	1902	16992618	Yes
2516	1270	1270.0	0.0	0.0	Bee and wasp venoms.	E Habermann	Science	1972	4113805	No
2517	7620	1270.0	253.62	42.3	Antioxidant activity applying an improved ABTS radical cation decolorization assay.	R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-Evans	Free Radic Biol Med	1999	10381194	Yes
2518	2538	1269.0	0.0	0.0	A rapid, sensitive, and specific method for the determination of protein in dilute solution.	W Schaffner, C Weissmann	Anal Biochem	1973	4128882	Yes
2519	1269	1269.0	48.8	48.8	Translating social ecological theory into guidelines for community health promotion.	D Stokols	Am J Health Promot	1996	10159709	No
2520	1269	1269.0	29.63	29.6	Oxidative stress in neurodegeneration: cause or consequence?	Julie K Andersen	Nat Med	2004	15298006	No
2521	1268	1268.0	37.49	37.5	Qinghaosu (artemisinin): an antimalarial drug from China.	D L Klayman	Science	1985	3887571	No
2522	8864	1266.3	257.96	36.9	Cancer statistics, 2008.	Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J Thun	CA Cancer J Clin	2008	18287387	Yes
2523	1266	1266.0	50.72	50.7	Social phobia.	M R Liebowitz	Mod Probl Pharmacopsychiatry	1987	2885745	Yes
2524	2531	1265.5	49.19	24.6	Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis.	M Fried, D M Crothers	Nucleic Acids Res	1981	6275366	Yes
2525	1265	1265.0	28.4	28.4	Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration.	T A Springer	Annu Rev Physiol	1995	7778885	No
2526	1265	1265.0	29.06	29.1	Refined structure of the nicotinic acetylcholine receptor at 4A resolution.	Nigel Unwin	J Mol Biol	2005	15701510	Yes
2527	13905	1264.1	381.41	34.7	The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.	Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J Roccella	JAMA	2003	12748199	No
2528	2528	1264.0	52.62	26.3	The molecular biology of axon guidance.	M Tessier-Lavigne, C S Goodman	Science	1996	8895455	No
2529	1264	1264.0	38.7	38.7	Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?	Thomas Grobner	Nephrol Dial Transplant	2006	16431890	Yes
2530	3790	1263.3	98.22	32.7	Atomic force microscope.	Binnig, Quate, Gerber	Phys Rev Lett	1986	10033323	Yes
2531	1263	1263.0	0.0	0.0	Structure and function of intercellular junctions.	L A Staehelin	Int Rev Cytol	1974	4611943	No
2532	1263	1263.0	26.21	26.2	Signal transduction via the MAP kinases: proceed at your own RSK.	J Blenis	Proc Natl Acad Sci U S A	1993	8392180	No
2533	1263	1263.0	32.52	32.5	Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics.	G L Semenza	Oncogene	2010	19946328	No
2534	1263	1263.0	42.17	42.2	The amazing osteocyte.	Lynda F Bonewald	J Bone Miner Res	2011	21254230	No
2535	2525	1262.5	61.2	30.6	Microenvironmental regulation of metastasis.	Johanna A Joyce, Jeffrey W Pollard	Nat Rev Cancer	2009	19279573	No
2536	1262	1262.0	31.75	31.8	Apoptosis.	J J Cohen	Immunol Today	1993	8466628	No
2537	1262	1262.0	30.27	30.3	Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults.	Bei-Fan Zhou	Biomed Environ Sci	2002	12046553	Yes
2538	2523	1261.5	0.0	0.0	Post-embryonic cell lineages of the nematode, Caenorhabditis elegans.	J E Sulston, H R Horvitz	Dev Biol	1977	838129	Yes
2539	3784	1261.3	92.49	30.8	Functional porous coordination polymers.	Susumu Kitagawa, Ryo Kitaura, Shin-ichiro Noro	Angew Chem Int Ed Engl	2004	15114565	Yes
2540	1261	1261.0	20.83	20.8	Antigen receptor tail clue.	M Reth	Nature	1989	2927501	Yes
2541	3783	1261.0	104.94	35.0	Nitric oxide and peroxynitrite in health and disease.	Pál Pacher, Joseph S Beckman, Lucas Liaudet	Physiol Rev	2007	17237348	No
2542	1261	1261.0	47.88	47.9	The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles.	Eleonore Fröhlich	Int J Nanomedicine	2012	23144561	No
2543	2521	1260.5	46.7	23.4	Live or let die: the cell's response to p53.	Karen H Vousden, Xin Lu	Nat Rev Cancer	2002	12154352	No
2544	1260	1260.0	25.99	26.0	SETOR: hardware-lighted three-dimensional solid model representations of macromolecules.	S V Evans	J Mol Graph	1993	8347566	Yes
2545	1260	1260.0	40.24	40.2	Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology.	J J Gross	J Pers Soc Psychol	1998	9457784	Yes
2546	1260	1260.0	29.18	29.2	Oxyradicals and DNA damage.	L J Marnett	Carcinogenesis	2000	10688856	No
2547	1260	1260.0	60.29	60.3	Macrophage Polarization.	Peter J Murray	Annu Rev Physiol	2017	27813830	No
2548	2518	1259.0	80.71	40.4	Oxidative mechanisms in the toxicity of metal ions.	S J Stohs, D Bagchi	Free Radic Biol Med	1995	7744317	No
2549	2518	1259.0	45.95	23.0	DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.	Christopher J Bakkenist, Michael B Kastan	Nature	2003	12556884	Yes
2550	2518	1259.0	55.03	27.5	The pathophysiology of mitochondrial cell death.	Douglas R Green, Guido Kroemer	Science	2004	15286356	No
2551	1259	1259.0	27.3	27.3	The stem-cell niche as an entity of action.	David T Scadden	Nature	2006	16810242	No
2552	1259	1259.0	37.17	37.2	Cytokinesis-block micronucleus cytome assay.	Michael Fenech	Nat Protoc	2007	17546000	Yes
2553	3776	1258.7	79.17	26.4	Calcium signalling: dynamics, homeostasis and remodelling.	Michael J Berridge, Martin D Bootman, H Llewelyn Roderick	Nat Rev Mol Cell Biol	2003	12838335	No
2554	2517	1258.5	57.03	28.5	Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface.	D A Brown, J K Rose	Cell	1992	1531449	Yes
2555	2517	1258.5	97.21	48.6	Malondialdehyde determination as index of lipid peroxidation.	H H Draper, M Hadley	Methods Enzymol	1990	2233309	Yes
2556	1258	1258.0	30.53	30.5	Short-term synaptic plasticity.	R S Zucker	Annu Rev Neurosci	1989	2648947	No
2557	1258	1258.0	31.51	31.5	Surrogate endpoints in clinical trials: definition and operational criteria.	R L Prentice	Stat Med	1989	2727467	Yes
2558	1258	1258.0	0.0	0.0	Strategy and tactics in protein chemistry.	B S Hartley	Biochem J	1970	4923920	No
2559	2515	1257.5	67.17	33.6	Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.	J L Weber, P E May	Am J Hum Genet	1989	2916582	Yes
2560	2515	1257.5	70.21	35.1	What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?	K C Berridge, T E Robinson	Brain Res Brain Res Rev	1998	9858756	No
2561	5029	1257.2	102.95	25.7	Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.	D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini	Science	2005	15718470	Yes
2562	1257	1257.0	33.87	33.9	Signaling through phosphatidylcholine breakdown.	J H Exton	J Biol Chem	1990	2104616	No
2563	2514	1257.0	63.08	31.5	Interneurons of the hippocampus.	T F Freund, G Buzsáki	Hippocampus	1996	8915675	No
2564	2514	1257.0	74.67	37.3	A cognitive model of posttraumatic stress disorder.	A Ehlers, D M Clark	Behav Res Ther	2000	10761279	No
2565	1257	1257.0	0.0	0.0	The effective period of preventive antibiotic action in experimental incisions and dermal lesions.	J F Burke	Surgery	1961	16722001	Yes
2566	1256	1256.0	31.85	31.9	The mitochondrial electron transport and oxidative phosphorylation system.	Y Hatefi	Annu Rev Biochem	1985	2862839	No
2567	1256	1256.0	0.0	0.0	A restriction point for control of normal animal cell proliferation.	A B Pardee	Proc Natl Acad Sci U S A	1974	4524638	Yes
2568	1256	1256.0	60.16	60.2	New norms of upper limb fat and muscle areas for assessment of nutritional status.	A R Frisancho	Am J Clin Nutr	1981	6975564	Yes
2569	1256	1256.0	42.53	42.5	Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells.	R Lotan	Biochim Biophys Acta	1980	6989400	No
2570	2511	1255.5	62.45	31.2	The free radical theory of aging matures.	K B Beckman, B N Ames	Physiol Rev	1998	9562038	No
2571	1255	1255.0	27.94	27.9	Life, death, and the pursuit of apoptosis.	E White	Genes Dev	1996	8557188	No
2572	1255	1255.0	25.84	25.8	Endocytosis and molecular sorting.	I Mellman	Annu Rev Cell Dev Biol	1996	8970738	No
2573	1255	1255.0	25.4	25.4	Searching for genetic determinants in the new millennium.	N J Risch	Nature	2000	10866211	No
2574	1255	1255.0	29.05	29.1	Metastatic bone disease: clinical features, pathophysiology and treatment strategies.	R E Coleman	Cancer Treat Rev	2001	11417967	No
2575	1255	1255.0	29.73	29.7	Pathways of oxidative damage.	James A Imlay	Annu Rev Microbiol	2003	14527285	No
2576	2509	1254.5	0.0	0.0	Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines.	G J Todaro, H Green	J Cell Biol	1963	13985244	Yes
2577	3759	1253.0	169.41	56.5	In search of how people change. Applications to addictive behaviors.	J O Prochaska, C C DiClemente, J C Norcross	Am Psychol	1992	1329589	Yes
2578	1253	1253.0	26.61	26.6	Solving structures of protein complexes by molecular replacement with Phaser.	Airlie J McCoy	Acta Crystallogr D Biol Crystallogr	2007	17164524	Yes
2579	2505	1252.5	57.99	29.0	DNA sequence analysis with a modified bacteriophage T7 DNA polymerase.	S Tabor, C C Richardson	Proc Natl Acad Sci U S A	1987	3474623	Yes
2580	2504	1252.0	75.92	38.0	An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat.	Sun Ho Kim, Jin Mo Chung	Pain	1992	1333581	Yes
2581	1252	1252.0	33.75	33.8	The sympathetic control of blood pressure.	Patrice G Guyenet	Nat Rev Neurosci	2006	16760914	No
2582	2503	1251.5	0.0	0.0	Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats.	J Altman, G D Das	J Comp Neurol	1965	5861717	Yes
2583	1251	1251.0	27.14	27.1	The enzymes, regulation, and genetics of bile acid synthesis.	David W Russell	Annu Rev Biochem	2003	12543708	No
2584	2501	1250.5	62.26	31.1	Pharmacology and functions of metabotropic glutamate receptors.	P J Conn, J P Pin	Annu Rev Pharmacol Toxicol	1997	9131252	No
2585	2500	1250.0	73.1	36.5	Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.	J I Morgan, T Curran	Annu Rev Neurosci	1991	1903243	No
2586	1250	1250.0	34.95	35.0	Tumor angiogenesis.	J Folkman	Adv Cancer Res	1985	2581424	No
2587	1250	1250.0	0.0	0.0	Metabolic stability and epigenesis in randomly constructed genetic nets.	S A Kauffman	J Theor Biol	1969	5803332	Yes
2588	1250	1250.0	27.65	27.6	Physiological concentrations of purines and pyrimidines.	T W Traut	Mol Cell Biochem	1994	7877593	No
2589	1250	1250.0	59.08	59.1	Mechanisms linking social ties and support to physical and mental health.	Peggy A Thoits	J Health Soc Behav	2011	21673143	No
2590	1250	1250.0	41.6	41.6	Electrocatalyst approaches and challenges for automotive fuel cells.	Mark K Debe	Nature	2012	22678278	Yes
2591	2499	1249.5	126.91	63.5	A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain.	M Roland, R Morris	Spine (Phila Pa 1976)	1983	6222486	Yes
2592	2499	1249.5	0.0	0.0	Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies.	H A Edmondson, P E Steiner	Cancer	1954	13160935	Yes
2593	1249	1249.0	31.92	31.9	Rapid evolution of a protein in vitro by DNA shuffling.	W P Stemmer	Nature	1994	8047147	Yes
2594	1249	1249.0	22.35	22.4	The molecular motor toolbox for intracellular transport.	Ronald D Vale	Cell	2003	12600311	No
2595	1248	1248.0	31.14	31.1	Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.	J Deisenhofer	Biochemistry	1981	7236608	Yes
2596	1248	1248.0	24.9	24.9	STATs: signal transducers and activators of transcription.	J N Ihle	Cell	1996	8608586	No
2597	1248	1248.0	23.77	23.8	Mobile elements: drivers of genome evolution.	Haig H Kazazian	Science	2004	15016989	No
2598	1248	1248.0	32.51	32.5	Plasmonics: merging photonics and electronics at nanoscale dimensions.	Ekmel Ozbay	Science	2006	16410515	Yes
2599	7487	1247.8	193.16	32.2	Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research.	Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat Robles	Bioinformatics	2005	16081474	Yes
2600	6235	1247.0	118.96	23.8	Crystal structure of the nucleosome core particle at 2.8 A resolution.	K Luger, A W Mäder, R K Richmond, D F Sargent, T J Richmond	Nature	1997	9305837	Yes
2601	2494	1247.0	66.73	33.4	EasySpin, a comprehensive software package for spectral simulation and analysis in EPR.	Stefan Stoll, Arthur Schweiger	J Magn Reson	2006	16188474	Yes
2602	1247	1247.0	40.92	40.9	Amino acids: metabolism, functions, and nutrition.	Guoyao Wu	Amino Acids	2009	19301095	No
2603	1247	1247.0	41.92	41.9	Receiver operating characteristic curve in diagnostic test assessment.	Jayawant N Mandrekar	J Thorac Oncol	2010	20736804	No
2604	2493	1246.5	62.72	31.4	Neuronal plasticity: increasing the gain in pain.	C J Woolf, M W Salter	Science	2000	10846153	No
2605	3739	1246.3	100.84	33.6	Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion.	Robert D Schreiber, Lloyd J Old, Mark J Smyth	Science	2011	21436444	No
2606	2492	1246.0	0.0	0.0	Surgical risk as related to time of intervention in the repair of intracranial aneurysms.	W E Hunt, R M Hess	J Neurosurg	1968	5635959	Yes
2607	1246	1246.0	30.61	30.6	Non-Smad pathways in TGF-beta signaling.	Ying E Zhang	Cell Res	2009	19114990	No
2608	1246	1246.0	0.0	0.0	An approximate distribution of estimates of variance components.	F E Satterthwaite	Biometrics	1946	20287815	Yes
2609	2491	1245.5	44.51	22.3	The DNA damage response: putting checkpoints in perspective.	B B Zhou, S J Elledge	Nature	2000	11100718	No
2610	2491	1245.5	109.52	54.8	Elements of cancer immunity and the cancer-immune set point.	Daniel S Chen, Ira Mellman	Nature	2017	28102259	No
2611	1245	1245.0	27.83	27.8	Long-term potentiation and memory.	M A Lynch	Physiol Rev	2004	14715912	No
2612	3734	1244.7	88.83	29.6	Tissue cells feel and respond to the stiffness of their substrate.	Dennis E Discher, Paul Janmey, Yu-Li Wang	Science	2005	16293750	No
2613	1244	1244.0	38.04	38.0	Chronic disease management: what will it take to improve care for chronic illness?	E H Wagner	Eff Clin Pract	1998	10345255	No
2614	1244	1244.0	0.0	0.0	A modification of receptor theory.	R P Stephenson	Br J Pharmacol Chemother	1956	13383117	Yes
2615	8696	1242.3	251.73	36.0	BLAST+: architecture and applications.	Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L Madden	BMC Bioinformatics	2009	20003500	Yes
2616	1242	1242.0	28.17	28.2	Liver fibrosis -- from bench to bedside.	Scott L Friedman	J Hepatol	2003	12591185	No
2617	1242	1242.0	37.83	37.8	Endometriosis.	Serdar E Bulun	N Engl J Med	2009	19144942	No
2618	3724	1241.3	89.2	29.7	Dystrophin: the protein product of the Duchenne muscular dystrophy locus.	E P Hoffman, R H Brown, L M Kunkel	Cell	1987	3319190	Yes
2619	1241	1241.0	0.0	0.0	Optimal foraging, the marginal value theorem.	E L Charnov	Theor Popul Biol	1976	1273796	Yes
2620	2482	1241.0	90.65	45.3	The stunned myocardium: prolonged, postischemic ventricular dysfunction.	E Braunwald, R A Kloner	Circulation	1982	6754130	No
2621	1241	1241.0	42.39	42.4	How is the level of free arachidonic acid controlled in mammalian cells?	R F Irvine	Biochem J	1982	6810878	No
2622	1241	1241.0	32.35	32.4	Psychological and neural mechanisms of the affective dimension of pain.	D D Price	Science	2000	10846154	No
2623	1241	1241.0	0.0	0.0	Sequential tests for the detection of linkage.	N E Morton	Am J Hum Genet	1955	13258560	Yes
2624	1241	1241.0	32.16	32.2	Pain and emotion interactions in subregions of the cingulate gyrus.	Brent A Vogt	Nat Rev Neurosci	2005	15995724	No
2625	4963	1240.8	144.25	36.1	Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.	N Weidner, J P Semple, W R Welch, J Folkman	N Engl J Med	1991	1701519	Yes
2626	2481	1240.5	48.32	24.2	CpG islands in vertebrate genomes.	M Gardiner-Garden, M Frommer	J Mol Biol	1987	3656447	Yes
2627	2480	1240.0	154.53	77.3	Facial nerve grading system.	J W House, D E Brackmann	Otolaryngol Head Neck Surg	1985	3921901	Yes
2628	1240	1240.0	0.0	0.0	Displaced proximal humeral fractures. I. Classification and evaluation.	C S Neer	J Bone Joint Surg Am	1970	5455339	Yes
2629	1240	1240.0	35.69	35.7	Peptide antibiotics and their role in innate immunity.	H G Boman	Annu Rev Immunol	1995	7612236	No
2630	2479	1239.5	68.68	34.3	Nitric oxide synthases: roles, tolls, and controls.	C Nathan, Q W Xie	Cell	1994	7522969	No
2631	3714	1238.0	92.35	30.8	Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm.	Y Zhang, M Brady, S Smith	IEEE Trans Med Imaging	2001	11293691	Yes
2632	1238	1238.0	21.55	21.6	Cancer susceptibility and the functions of BRCA1 and BRCA2.	Ashok R Venkitaraman	Cell	2002	11832208	No
2633	2476	1238.0	88.93	44.5	Functional interactions between the gut microbiota and host metabolism.	Valentina Tremaroli, Fredrik Bäckhed	Nature	2012	22972297	No
2634	1238	1238.0	64.01	64.0	PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors.	Anthony L Spek	Acta Crystallogr C Struct Chem	2015	25567569	Yes
2635	6185	1237.0	149.05	29.8	Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.	T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L Coffman	J Immunol	1986	2419430	Yes
2636	2474	1237.0	63.34	31.7	Genetic dissection of complex traits.	E S Lander, N J Schork	Science	1994	8091226	No
2637	1237	1237.0	29.8	29.8	Somatostatin and its receptor family.	Y C Patel	Front Neuroendocrinol	1999	10433861	No
2638	2474	1237.0	59.07	29.5	Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits.	Kornelia Polyak, Robert A Weinberg	Nat Rev Cancer	2009	19262571	No
2639	3710	1236.7	89.64	29.9	Thresholding of statistical maps in functional neuroimaging using the false discovery rate.	Christopher R Genovese, Nicole A Lazar, Thomas Nichols	Neuroimage	2002	11906227	Yes
2640	3710	1236.7	127.43	42.5	Rehospitalizations among patients in the Medicare fee-for-service program.	Stephen F Jencks, Mark V Williams, Eric A Coleman	N Engl J Med	2009	19339721	Yes
2641	1236	1236.0	0.0	0.0	Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus.	P Rakic	J Comp Neurol	1971	4101340	Yes
2642	1236	1236.0	29.4	29.4	Reactive oxygen radicals in signaling and damage in the ischemic brain.	P H Chan	J Cereb Blood Flow Metab	2001	11149664	No
2643	2472	1236.0	0.0	0.0	The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid.	B N Ames, D T Dubin	J Biol Chem	1960	13793161	Yes
2644	2472	1236.0	83.7	41.9	Origins and evolution of antibiotic resistance.	Julian Davies, Dorothy Davies	Microbiol Mol Biol Rev	2010	20805405	No
2645	2470	1235.0	46.48	23.2	Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection.	C Li, W H Wong	Proc Natl Acad Sci U S A	2001	11134512	Yes
2646	4936	1234.0	189.45	47.4	FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data.	Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs Schoffelen	Comput Intell Neurosci	2011	21253357	Yes
2647	2467	1233.5	61.56	30.8	Molecular mechanisms of action of steroid/thyroid receptor superfamily members.	M J Tsai, B W O'Malley	Annu Rev Biochem	1994	7979245	No
2648	13566	1233.3	329.21	29.9	New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada.	P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G Gwyther	J Natl Cancer Inst	2000	10655437	No
2649	1233	1233.0	37.68	37.7	Calcium channel modulation by neurotransmitters, enzymes and drugs.	H Reuter	Nature	1983	6131381	No
2650	1233	1233.0	43.74	43.7	Plasma perspective on strong field multiphoton ionization.	Corkum	Phys Rev Lett	1993	10054556	Yes
2651	1233	1233.0	33.35	33.4	The biochemistry and medical significance of the flavonoids.	Bent H Havsteen	Pharmacol Ther	2002	12453566	No
2652	1233	1233.0	33.91	33.9	How brains beware: neural mechanisms of emotional attention.	Patrik Vuilleumier	Trends Cogn Sci	2005	16289871	Yes
2653	3698	1232.7	101.18	33.7	Molecular characterization of a peripheral receptor for cannabinoids.	S Munro, K L Thomas, M Abu-Shaar	Nature	1993	7689702	Yes
2654	3698	1232.7	111.72	37.2	Oxidants, antioxidants, and the degenerative diseases of aging.	B N Ames, M K Shigenaga, T M Hagen	Proc Natl Acad Sci U S A	1993	8367443	No
2655	2465	1232.5	48.9	24.4	Gene silencing in cancer in association with promoter hypermethylation.	James G Herman, Stephen B Baylin	N Engl J Med	2003	14627790	No
2656	2465	1232.5	271.17	135.6	The biology, function, and biomedical applications of exosomes.	Raghu Kalluri, Valerie S LeBleu	Science	2020	32029601	No
2657	1232	1232.0	24.4	24.4	Cytokines induce the development of functionally heterogeneous T helper cell subsets.	A O'Garra	Immunity	1998	9529145	No
2658	2463	1231.5	46.89	23.4	The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.	T Maehama, J E Dixon	J Biol Chem	1998	9593664	Yes
2659	2463	1231.5	51.28	25.6	Tumorigenesis and the angiogenic switch.	Gabriele Bergers, Laura E Benjamin	Nat Rev Cancer	2003	12778130	No
2660	1231	1231.0	26.81	26.8	Human natural killer cells.	Michael A Caligiuri	Blood	2008	18650461	No
2661	4920	1230.0	111.11	27.8	A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.	Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry Sharpless	Angew Chem Int Ed Engl	2002	12203546	Yes
2662	1230	1230.0	26.67	26.7	Neuroligins and neurexins link synaptic function to cognitive disease.	Thomas C Südhof	Nature	2008	18923512	No
2663	3690	1230.0	89.48	29.8	Evolution and functions of long noncoding RNAs.	Chris P Ponting, Peter L Oliver, Wolf Reik	Cell	2009	19239885	No
2664	2459	1229.5	97.91	49.0	Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks.	Susan Whitfield-Gabrieli, Alfonso Nieto-Castanon	Brain Connect	2012	22642651	Yes
2665	2458	1229.0	55.13	27.6	The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications.	P M Sharp, W H Li	Nucleic Acids Res	1987	3547335	Yes
2666	1229	1229.0	35.86	35.9	Invasive aspergillosis.	D W Denning	Clin Infect Dis	1998	9564455	No
2667	2458	1229.0	60.79	30.4	Drug delivery systems: entering the mainstream.	Theresa M Allen, Pieter R Cullis	Science	2004	15031496	Yes
2668	1229	1229.0	30.84	30.8	Overview of general physiologic features and functions of vitamin D.	Hector F DeLuca	Am J Clin Nutr	2004	15585789	No
2669	3686	1228.7	83.06	27.7	Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo.	Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen	Science	2005	15831717	Yes
2670	2457	1228.5	0.0	0.0	Construct validity in psychological tests.	L J Cronbach, P E Meehl	Psychol Bull	1955	13245896	Yes
2671	1228	1228.0	0.0	0.0	Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion.	P O Seglen	Exp Cell Res	1973	4358115	Yes
2672	1228	1228.0	27.03	27.0	S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles.	R Donato	Int J Biochem Cell Biol	2001	11390274	No
2673	1227	1227.0	54.64	54.6	Biomaterial-centered infection: microbial adhesion versus tissue integration.	A G Gristina	Science	1987	3629258	Yes
2674	1227	1227.0	25.97	26.0	Antigen-presenting function of the macrophage.	E R Unanue	Annu Rev Immunol	1984	6242349	No
2675	1227	1227.0	30.19	30.2	Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase.	P Kuzmic	Anal Biochem	1996	8660575	Yes
2676	1227	1227.0	32.58	32.6	Low density lipoprotein oxidation and its pathobiological significance.	D Steinberg	J Biol Chem	1997	9261091	No
2677	2453	1226.5	55.78	27.9	Can the pharmaceutical industry reduce attrition rates?	Ismail Kola, John Landis	Nat Rev Drug Discov	2004	15286737	No
2678	2453	1226.5	63.14	31.6	Nanostructures in biodiagnostics.	Nathaniel L Rosi, Chad A Mirkin	Chem Rev	2005	15826019	No
2679	6132	1226.4	193.23	38.6	Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.	J S Beckman, T W Beckman, J Chen, P A Marshall, B A Freeman	Proc Natl Acad Sci U S A	1990	2154753	Yes
2680	2452	1226.0	104.57	52.3	Cisplatin in cancer therapy: molecular mechanisms of action.	Shaloam Dasari, Paul Bernard Tchounwou	Eur J Pharmacol	2014	25058905	No
2681	2451	1225.5	50.92	25.5	ERBB receptors and cancer: the complexity of targeted inhibitors.	Nancy E Hynes, Heidi A Lane	Nat Rev Cancer	2005	15864276	No
2682	2450	1225.0	48.39	24.2	Checkpoints: controls that ensure the order of cell cycle events.	L H Hartwell, T A Weinert	Science	1989	2683079	No
2683	1225	1225.0	55.32	55.3	Continuous improvement as an ideal in health care.	D M Berwick	N Engl J Med	1989	2909878	Yes
2684	1225	1225.0	28.57	28.6	The prefrontal cortex and cognitive control.	E K Miller	Nat Rev Neurosci	2000	11252769	No
2685	1225	1225.0	49.86	49.9	What is self-rated health and why does it predict mortality? Towards a unified conceptual model.	Marja Jylhä	Soc Sci Med	2009	19520474	Yes
2686	2449	1224.5	66.33	33.2	Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.	Ajay Kumar Gupta, Mona Gupta	Biomaterials	2005	15626447	No
2687	3673	1224.3	109.56	36.5	The functional anatomy of basal ganglia disorders.	R L Albin, A B Young, J B Penney	Trends Neurosci	1989	2479133	No
2688	2447	1223.5	0.0	0.0	Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.	G K McMaster, G G Carmichael	Proc Natl Acad Sci U S A	1977	73185	Yes
2689	3670	1223.3	349.08	116.4	Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles.	Aldenor G Santos, Gisele O da Rocha, Jailson B de Andrade	Sci Rep	2019	30626917	Yes
2690	1223	1223.0	22.3	22.3	Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture.	H E Ruley	Nature	1983	6308473	Yes
2691	1223	1223.0	26.8	26.8	Heterotrimeric G proteins: organizers of transmembrane signals.	E J Neer	Cell	1995	7834744	No
2692	1223	1223.0	31.77	31.8	Drug delivery and targeting.	R Langer	Nature	1998	9579855	No
2693	1223	1223.0	33.55	33.5	Neural simulation of action: a unifying mechanism for motor cognition.	M Jeannerod	Neuroimage	2001	11373140	No
2694	1223	1223.0	26.59	26.6	Molecular physiology of low-voltage-activated t-type calcium channels.	Edward Perez-Reyes	Physiol Rev	2003	12506128	No
2695	3669	1223.0	97.73	32.6	Bacterial biofilms: from the natural environment to infectious diseases.	Luanne Hall-Stoodley, J William Costerton, Paul Stoodley	Nat Rev Microbiol	2004	15040259	No
2696	1222	1222.0	35.17	35.2	Varieties of impulsivity.	J L Evenden	Psychopharmacology (Berl)	1999	10550486	No
2697	1222	1222.0	0.0	0.0	The diagnosis of ischaemic heart pain and intermittent claudication in field surveys.	G A Rose	Bull World Health Organ	1962	13974778	Yes
2698	1222	1222.0	34.74	34.7	Plant productivity and environment.	J S Boyer	Science	1982	17808529	Yes
2699	1222	1222.0	30.12	30.1	Recent advances in neuroblastoma.	John M Maris	N Engl J Med	2010	20558371	No
2700	2444	1222.0	63.29	31.6	Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications.	Felix Krueger, Simon R Andrews	Bioinformatics	2011	21493656	Yes
2701	1221	1221.0	56.73	56.7	A cognitive approach to panic.	D M Clark	Behav Res Ther	1986	3741311	Yes
2702	1221	1221.0	38.53	38.5	Antioxidants in human health and disease.	B Halliwell	Annu Rev Nutr	1996	8839918	No
2703	1221	1221.0	93.66	93.7	The Global Epidemic of the Metabolic Syndrome.	Mohammad G Saklayen	Curr Hypertens Rep	2018	29480368	No
2704	3661	1220.3	107.55	35.9	Validation of the Insomnia Severity Index as an outcome measure for insomnia research.	C H. Bastien, A Vallières, C M. Morin	Sleep Med	2001	11438246	Yes
2705	2440	1220.0	39.57	19.8	A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback.	D Tautz, C Pfeifle	Chromosoma	1989	2476281	Yes
2706	1220	1220.0	25.34	25.3	MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation.	R N Germain	Cell	1994	8293464	No
2707	1220	1220.0	30.78	30.8	Endothelial-leukocyte adhesion molecules.	M P Bevilacqua	Annu Rev Immunol	1993	8476577	No
2708	1220	1220.0	26.9	26.9	Nuclear factor-kappaB: the enemy within.	Bharat B Aggarwal	Cancer Cell	2004	15380510	No
2709	1220	1220.0	168.96	169.0	A Review of Coronavirus Disease-2019 (COVID-19).	Tanu Singhal	Indian J Pediatr	2020	32166607	No
2710	1219	1219.0	25.98	26.0	The roles of intracellular protein-degradation pathways in neurodegeneration.	David C Rubinsztein	Nature	2006	17051204	No
2711	1219	1219.0	40.35	40.4	Thermal properties of graphene and nanostructured carbon materials.	Alexander A Balandin	Nat Mater	2011	21778997	Yes
2712	3655	1218.3	86.72	28.9	Global and societal implications of the diabetes epidemic.	P Zimmet, K G Alberti, J Shaw	Nature	2001	11742409	No
2713	2436	1218.0	149.63	74.8	A joint coordinate system for the clinical description of three-dimensional motions: application to the knee.	E S Grood, W J Suntay	J Biomech Eng	1983	6865355	Yes
2714	1218	1218.0	27.22	27.2	Measuring information transfer	Schreiber	Phys Rev Lett	2000	10991308	Yes
2715	1218	1218.0	31.08	31.1	Hydrogen sulphide and its therapeutic potential.	Csaba Szabó	Nat Rev Drug Discov	2007	17948022	No
2716	1218	1218.0	40.77	40.8	The epidemiology of adult obstructive sleep apnea.	Naresh M Punjabi	Proc Am Thorac Soc	2008	18250205	No
2717	2436	1218.0	61.23	30.6	Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm.	Subhra K Biswas, Alberto Mantovani	Nat Immunol	2010	20856220	No
2718	2436	1218.0	69.42	34.7	Tumor metastasis: molecular insights and evolving paradigms.	Scott Valastyan, Robert A Weinberg	Cell	2011	22000009	No
2719	1217	1217.0	43.86	43.9	Transduction of psychosocial stress into the neurobiology of recurrent affective disorder.	R M Post	Am J Psychiatry	1992	1353322	No
2720	1217	1217.0	33.87	33.9	Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections.	F Hefti	J Neurosci	1986	3746405	Yes
2721	1217	1217.0	29.37	29.4	Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.	Hiroshi Takayanagi	Nat Rev Immunol	2007	17380158	No
2722	3649	1216.3	99.09	33.0	Fast model-based estimation of ancestry in unrelated individuals.	David H Alexander, John Novembre, Kenneth Lange	Genome Res	2009	19648217	Yes
2723	2432	1216.0	0.0	0.0	High resolution acrylamide gel electrophoresis of histones.	S Panyim, R Chalkley	Arch Biochem Biophys	1969	5778650	Yes
2724	1216	1216.0	22.9	22.9	Histone-deacetylase inhibitors: novel drugs for the treatment of cancer.	Ricky W Johnstone	Nat Rev Drug Discov	2002	12120280	No
2725	3647	1215.7	103.65	34.6	Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles.	Günter Oberdörster, Eva Oberdörster, Jan Oberdörster	Environ Health Perspect	2005	16002369	No
2726	2431	1215.5	57.24	28.6	Cell cycle, CDKs and cancer: a changing paradigm.	Marcos Malumbres, Mariano Barbacid	Nat Rev Cancer	2009	19238148	No
2727	1215	1215.0	33.56	33.6	Internal models for motor control and trajectory planning.	M Kawato	Curr Opin Neurobiol	1999	10607637	No
2728	1215	1215.0	29.95	29.9	Primate anterior cingulate cortex: where motor control, drive and cognition interface.	T Paus	Nat Rev Neurosci	2001	11389475	No
2729	2430	1215.0	0.0	0.0	The Aggregation Of Blood Platelets.	G V Born, M J Cross	J Physiol	1963	14056485	Yes
2730	1215	1215.0	26.48	26.5	Recognition and processing of ubiquitin-protein conjugates by the proteasome.	Daniel Finley	Annu Rev Biochem	2009	19489727	No
2731	4859	1214.8	103.42	25.9	Interleukin-10 and the interleukin-10 receptor.	K W Moore, R de Waal Malefyt, R L Coffman, A O'Garra	Annu Rev Immunol	2001	11244051	No
2732	1214	1214.0	0.0	0.0	Measurement of feelings using visual analogue scales.	R C Aitken	Proc R Soc Med	1969	4899510	No
2733	3641	1213.7	62.44	20.8	A system for stable expression of short interfering RNAs in mammalian cells.	Thijn R Brummelkamp, René Bernards, Reuven Agami	Science	2002	11910072	Yes
2734	1213	1213.0	41.85	41.9	Inhibition and facilitation of nucleic acid amplification.	I G Wilson	Appl Environ Microbiol	1997	9327537	No
2735	1213	1213.0	42.73	42.7	AmpC beta-lactamases.	George A Jacoby	Clin Microbiol Rev	2009	19136439	No
2736	2426	1213.0	53.59	26.8	The canonical Notch signaling pathway: unfolding the activation mechanism.	Raphael Kopan, Maria Xenia G Ilagan	Cell	2009	19379690	No
2737	1212	1212.0	61.42	61.4	Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale.	Anna Maria Carlsson	Pain	1983	6602967	Yes
2738	1212	1212.0	32.1	32.1	The lipocalin protein family: structure and function.	D R Flower	Biochem J	1996	8761444	No
2739	2424	1212.0	53.83	26.9	Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy.	S W Hell, J Wichmann	Opt Lett	1994	19844443	Yes
2740	1212	1212.0	0.0	0.0	Observations on the isolated phrenic nerve diaphragm preparation of the rat.	E Bulbring	Br J Pharmacol Chemother	1946	20999334	Yes
2741	2423	1211.5	65.07	32.5	Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications.	M A Pfeffer, E Braunwald	Circulation	1990	2138525	No
2742	1211	1211.0	25.9	25.9	Dendritic cells: unique leukocyte populations which control the primary immune response.	D N Hart	Blood	1997	9345009	No
2743	1211	1211.0	37.56	37.6	Risk and maintenance factors for eating pathology: a meta-analytic review.	Eric Stice	Psychol Bull	2002	12206196	No
2744	1211	1211.0	0.0	0.0	Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.	J M Van Rossum	Arch Int Pharmacodyn Ther	1963	13996119	Yes
2745	1211	1211.0	0.0	0.0	A simple objective technique for measuring flexibility in thinking.	E A Berg	J Gen Psychol	1948	18889466	Yes
2746	1210	1210.0	0.0	0.0	Experience from a multicentre stroke register: a preliminary report.	S Hatano	Bull World Health Organ	1976	1088404	Yes
2747	1210	1210.0	28.55	28.6	Growth factors and cancer.	S A Aaronson	Science	1991	1659742	No
2748	1210	1210.0	0.0	0.0	A comparison of canal preparations in straight and curved root canals.	S W Schneider	Oral Surg Oral Med Oral Pathol	1971	5284110	Yes
2749	2420	1210.0	59.73	29.9	Decision curve analysis: a novel method for evaluating prediction models.	Andrew J Vickers, Elena B Elkin	Med Decis Making	2006	17099194	Yes
2750	2420	1210.0	66.54	33.3	Integrins in cancer: biological implications and therapeutic opportunities.	Jay S Desgrosellier, David A Cheresh	Nat Rev Cancer	2010	20029421	No
2751	1210	1210.0	57.03	57.0	Periodontitis: from microbial immune subversion to systemic inflammation.	George Hajishengallis	Nat Rev Immunol	2015	25534621	No
2752	1209	1209.0	38.2	38.2	Linkage map of Escherichia coli K-12, edition 7.	B J Bachmann	Microbiol Rev	1983	6348505	No
2753	2418	1209.0	100.22	50.1	Reading senseless sentences: brain potentials reflect semantic incongruity.	M Kutas, S A Hillyard	Science	1980	7350657	Yes
2754	1209	1209.0	44.96	45.0	Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment.	S H Safe	Crit Rev Toxicol	1994	8037844	No
2755	2418	1209.0	56.75	28.4	Peroxisome proliferator-activated receptors: nuclear control of metabolism.	B Desvergne, W Wahli	Endocr Rev	1999	10529898	No
2756	1209	1209.0	147.19	147.2	Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults.	Jonas F Ludvigsson	Acta Paediatr	2020	32202343	Yes
2757	1208	1208.0	59.0	59.0	ROC methodology in radiologic imaging.	C E Metz	Invest Radiol	1986	3095258	No
2758	1208	1208.0	38.15	38.1	Persister cells.	Kim Lewis	Annu Rev Microbiol	2010	20528688	No
2759	2415	1207.5	76.0	38.0	Modeling and comparison of dissolution profiles.	P Costa, J M Sousa Lobo	Eur J Pharm Sci	2001	11297896	No
2760	1207	1207.0	0.0	0.0	Mutation selection and the natural history of cancer.	J Cairns	Nature	1975	1143315	Yes
2761	1207	1207.0	29.46	29.5	Bcl-2 initiates a new category of oncogenes: regulators of cell death.	S J Korsmeyer	Blood	1992	1498330	No
2762	2414	1207.0	64.63	32.3	A review of central 5-HT receptors and their function.	N M Barnes, T Sharp	Neuropharmacology	1999	10462127	No
2763	2413	1206.5	56.83	28.4	Quorum sensing in bacteria.	M B Miller, B L Bassler	Annu Rev Microbiol	2001	11544353	No
2764	1206	1206.0	0.0	0.0	The cytoarchitectonic organization of the spinal cord in the cat.	B Rexed	J Comp Neurol	1952	14946260	Yes
2765	2411	1205.5	47.12	23.6	Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.	C W Greider, E H Blackburn	Cell	1985	3907856	Yes
2766	2411	1205.5	66.63	33.3	Increasing incidence of thyroid cancer in the United States, 1973-2002.	Louise Davies, H Gilbert Welch	JAMA	2006	16684987	Yes
2767	1205	1205.0	30.11	30.1	Optimal experimental design for event-related fMRI.	A M Dale	Hum Brain Mapp	1999	10524601	Yes
2768	2409	1204.5	75.25	37.6	Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.	J E Hixson, D T Vernier	J Lipid Res	1990	2341813	Yes
2769	1204	1204.0	79.6	79.6	The problem of rigor in qualitative research.	M Sandelowski	ANS Adv Nurs Sci	1986	3083765	Yes
2770	1204	1204.0	23.73	23.7	Lipid rafts: elusive or illusive?	Sean Munro	Cell	2003	14622593	No
2771	1204	1204.0	36.35	36.4	Deconvoluting the context-dependent role for autophagy in cancer.	Eileen White	Nat Rev Cancer	2012	22534666	No
2772	2407	1203.5	0.0	0.0	Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells.	A Fabiato, F Fabiato	J Physiol (Paris)	1979	533865	Yes
2773	1203	1203.0	45.19	45.2	A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes.	S T Tiffany	Psychol Rev	1990	2186423	No
2774	1203	1203.0	25.24	25.2	Caspase structure, proteolytic substrates, and function during apoptotic cell death.	D W Nicholson	Cell Death Differ	1999	10578171	No
2775	2405	1202.5	60.37	30.2	Rising incidence of hepatocellular carcinoma in the United States.	H B El-Serag, A C Mason	N Engl J Med	1999	10072408	Yes
2776	1202	1202.0	41.49	41.5	Density matrix formulation for quantum renormalization groups.	White	Phys Rev Lett	1992	10046608	Yes
2777	1201	1201.0	22.19	22.2	Kinesin and dynein superfamily proteins and the mechanism of organelle transport.	N Hirokawa	Science	1998	9438838	No
2778	2402	1201.0	70.66	35.3	Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio.	Aluísio J D Barros, Vânia N Hirakata	BMC Med Res Methodol	2003	14567763	Yes
2779	1201	1201.0	39.63	39.6	How stigma interferes with mental health care.	Patrick Corrigan	Am Psychol	2004	15491256	Yes
2780	4804	1201.0	125.32	31.3	Universal sample preparation method for proteome analysis.	Jacek R Wiśniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias Mann	Nat Methods	2009	19377485	Yes
2781	1200	1200.0	34.68	34.7	A Wilcoxon-type test for trend.	J Cuzick	Stat Med	1985	3992076	Yes
2782	1200	1200.0	0.0	0.0	Assay of intestinal disaccharidases.	A Dahlqvist	Anal Biochem	1968	5636962	Yes
2783	1200	1200.0	29.55	29.6	The neuropathology of schizophrenia. A critical review of the data and their interpretation.	P J Harrison	Brain	1999	10219775	No
2784	2400	1200.0	48.09	24.0	Molecular chaperones in the cytosol: from nascent chain to folded protein.	F Ulrich Hartl, Manajit Hayer-Hartl	Science	2002	11884745	No
2785	1200	1200.0	31.73	31.7	Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence.	Earl S Ford	Diabetes Care	2005	15983333	No
2786	2400	1200.0	63.63	31.8	Neural systems of reinforcement for drug addiction: from actions to habits to compulsion.	Barry J Everitt, Trevor W Robbins	Nat Neurosci	2005	16251991	No
2787	2399	1199.5	52.66	26.3	Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms.	Eugenia E Calle, Rudolf Kaaks	Nat Rev Cancer	2004	15286738	No
2788	3598	1199.3	102.25	34.1	Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections.	H King, R E Aubert, W H Herman	Diabetes Care	1998	9727886	Yes
2789	3598	1199.3	83.21	27.7	Photodynamic therapy for cancer.	Dennis E J G J Dolmans, Dai Fukumura, Rakesh K Jain	Nat Rev Cancer	2003	12724736	No
2790	1199	1199.0	48.2	48.2	Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface.	E H Beachey	J Infect Dis	1981	7014727	No
2791	4795	1198.8	114.56	28.6	Autophagy fights disease through cellular self-digestion.	Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky	Nature	2008	18305538	No
2792	1198	1198.0	0.0	0.0	The concept of immunological surveillance.	F M Burnet	Prog Exp Tumor Res	1970	4921480	No
2793	1197	1197.0	49.83	49.8	A cochlear frequency-position function for several species--29 years later.	D D Greenwood	J Acoust Soc Am	1990	2373794	Yes
2794	1197	1197.0	25.8	25.8	The finer things in X-ray diffraction data collection.	J W Pflugrath	Acta Crystallogr D Biol Crystallogr	1999	10531521	Yes
2795	1197	1197.0	30.38	30.4	Comparative physiology of salt and water stress.	R. Munns	Plant Cell Environ	2002	11841667	Yes
2796	1197	1197.0	31.06	31.1	Polymer conjugates as anticancer nanomedicines.	Ruth Duncan	Nat Rev Cancer	2006	16900224	No
2797	1196	1196.0	0.0	0.0	Campylobacter enteritis: a "new" disease.	M B Skirrow	Br Med J	1977	871765	Yes
2798	1196	1196.0	28.32	28.3	Intracellular protein topogenesis.	G Blobel	Proc Natl Acad Sci U S A	1980	6929499	Yes
2799	2392	1196.0	64.24	32.1	Epidemiology and outcomes of osteoporotic fractures.	Steven R Cummings, L Joseph Melton	Lancet	2002	12049882	No
2800	1196	1196.0	0.0	0.0	Intra-sexual selection in Drosophila.	A J Bateman	Heredity (Edinb)	1948	18103134	Yes
2801	2391	1195.5	49.87	24.9	'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?	George Davey Smith, Shah Ebrahim	Int J Epidemiol	2003	12689998	No
2802	2391	1195.5	66.97	33.5	The cognitive control of emotion.	Kevin N Ochsner, James J Gross	Trends Cogn Sci	2005	15866151	No
2803	1195	1195.0	28.61	28.6	Rapid and sensitive sequence comparison with FASTP and FASTA.	W R Pearson	Methods Enzymol	1990	2156132	Yes
2804	1195	1195.0	0.0	0.0	Studies on phosphatidylcholine vesicles. Formation and physical characteristics.	C Huang	Biochemistry	1969	5777332	Yes
2805	2390	1195.0	64.01	32.0	Leukocyte-endothelial adhesion molecules.	T M Carlos, J M Harlan	Blood	1994	7522621	No
2806	1195	1195.0	24.72	24.7	Morphogenetic roles of classic cadherins.	M Takeichi	Curr Opin Cell Biol	1995	8573335	No
2807	3585	1195.0	72.98	24.3	Large-scale analysis of the yeast proteome by multidimensional protein identification technology.	M P Washburn, D Wolters, J R Yates	Nat Biotechnol	2001	11231557	Yes
2808	2390	1195.0	65.48	32.7	Meeting of minds: the medial frontal cortex and social cognition.	David M Amodio, Chris D Frith	Nat Rev Neurosci	2006	16552413	No
2809	1195	1195.0	28.69	28.7	Tumour necrosis factor and cancer.	Frances Balkwill	Nat Rev Cancer	2009	19343034	No
2810	2389	1194.5	134.49	67.2	A simple practice guide for dose conversion between animals and human.	Anroop B Nair, Shery Jacob	J Basic Clin Pharm	2016	27057123	No
2811	1194	1194.0	38.22	38.2	The pathogenesis of sepsis.	R C Bone	Ann Intern Med	1991	1872494	No
2812	1194	1194.0	42.78	42.8	The LMS method for constructing normalized growth standards.	T J Cole	Eur J Clin Nutr	1990	2354692	Yes
2813	1194	1194.0	27.11	27.1	Hybridization of denatured RNA transferred or dotted nitrocellulose paper.	P S Thomas	Methods Enzymol	1983	6194404	Yes
2814	1194	1194.0	61.12	61.1	Rating scales to assess depression in school-aged children.	M Kovacs	Acta Paedopsychiatr	1981	7025571	Yes
2815	1194	1194.0	26.87	26.9	Translating cell biology into therapeutic advances in Alzheimer's disease.	D J Selkoe	Nature	1999	10392577	No
2816	1194	1194.0	0.0	0.0	The relation of the trail making test to organic brain damage.	R M Reitan	J Consult Psychol	1955	13263471	Yes
2817	2387	1193.5	53.86	26.9	Transforming gene product of Rous sarcoma virus phosphorylates tyrosine.	T Hunter, B M Sefton	Proc Natl Acad Sci U S A	1980	6246487	Yes
2818	2387	1193.5	58.05	29.0	C-reactive protein: a critical update.	Mark B Pepys, Gideon M Hirschfield	J Clin Invest	2003	12813013	No
2819	1193	1193.0	29.71	29.7	Hereditary cancer, oncogenes, and antioncogenes.	A G Knudson	Cancer Res	1985	2983882	Yes
2820	7157	1192.8	135.54	22.6	Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.	S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T Tuschl	Nature	2001	11373684	Yes
2821	1192	1192.0	33.26	33.3	Sarcopenia: origins and clinical relevance.	I H Rosenberg	J Nutr	1997	9164280	No
2822	1192	1192.0	25.91	25.9	Microglia as a source and target of cytokines.	Uwe-Karsten Hanisch	Glia	2002	12379902	No
2823	1192	1192.0	23.36	23.4	IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors.	Yong-Jun Liu	Annu Rev Immunol	2005	15771572	No
2824	1192	1192.0	33.07	33.1	Infection in solid-organ transplant recipients.	Jay A Fishman	N Engl J Med	2007	18094380	No
2825	1191	1191.0	33.71	33.7	The effects of stressful life events on depression.	R C Kessler	Annu Rev Psychol	1997	9046559	No
2826	1191	1191.0	27.29	27.3	Brain tumors.	L M DeAngelis	N Engl J Med	2001	11150363	No
2827	1191	1191.0	25.13	25.1	Platelets in atherothrombosis.	Zaverio M Ruggeri	Nat Med	2002	12411949	No
2828	4764	1191.0	343.37	85.8	Rayyan-a web and mobile app for systematic reviews.	Mourad Ouzzani, Hossam Hammady, Zbys Fedorowicz, Ahmed Elmagarmid	Syst Rev	2016	27919275	Yes
2829	7144	1190.7	183.98	30.7	An obesity-associated gut microbiome with increased capacity for energy harvest.	Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I Gordon	Nature	2006	17183312	Yes
2830	2380	1190.0	78.08	39.0	Atomic structure and chemistry of human serum albumin.	X M He, D C Carter	Nature	1992	1630489	Yes
2831	2380	1190.0	67.64	33.8	Toll-like receptors and their crosstalk with other innate receptors in infection and immunity.	Taro Kawai, Shizuo Akira	Immunity	2011	21616434	No
2832	7139	1189.8	211.38	35.2	Free radicals and antioxidants in normal physiological functions and human disease.	Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua Telser	Int J Biochem Cell Biol	2007	16978905	No
2833	3569	1189.7	86.44	28.8	Functional diversity of helper T lymphocytes.	A K Abbas, K M Murphy, A Sher	Nature	1996	8893001	No
2834	2379	1189.5	42.7	21.4	Stats: transcriptional control and biological impact.	David E Levy, J E Darnell	Nat Rev Mol Cell Biol	2002	12209125	No
2835	2379	1189.5	54.84	27.4	Cellular processing of platinum anticancer drugs.	Dong Wang, Stephen J Lippard	Nat Rev Drug Discov	2005	15789122	No
2836	1189	1189.0	27.21	27.2	Mitochondrial transport of cations: channels, exchangers, and permeability transition.	P Bernardi	Physiol Rev	1999	10508231	No
2837	1189	1189.0	24.28	24.3	Basement membranes: structure, assembly and role in tumour angiogenesis.	Raghu Kalluri	Nat Rev Cancer	2003	12778132	No
2838	1189	1189.0	0.0	0.0	The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma.	W G Duncombe	Clin Chim Acta	1964	14122498	Yes
2839	1188	1188.0	34.92	34.9	High prevalence of vitamin D inadequacy and implications for health.	Michael F Holick	Mayo Clin Proc	2006	16529140	No
2840	2375	1187.5	0.0	0.0	Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine.	J D Peuler, G A Johnson	Life Sci	1977	904439	Yes
2841	2375	1187.5	46.78	23.4	Proliferation, cell cycle and apoptosis in cancer.	G I Evan, K H Vousden	Nature	2001	11357141	No
2842	1187	1187.0	36.77	36.8	Biosynthesis and metabolism of endothelium-derived nitric oxide.	L J Ignarro	Annu Rev Pharmacol Toxicol	1990	2188578	No
2843	3561	1187.0	112.38	37.5	MR diffusion tensor spectroscopy and imaging.	P J Basser, J Mattiello, D LeBihan	Biophys J	1994	8130344	Yes
2844	1187	1187.0	27.55	27.6	Evaluating medication effects outside of clinical trials: new-user designs.	Wayne A Ray	Am J Epidemiol	2003	14585769	Yes
2845	1187	1187.0	31.68	31.7	Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS.	Paul Willner	Neuropsychobiology	2005	16037678	No
2846	2373	1186.5	63.12	31.6	Imaging cognition II: An empirical review of 275 PET and fMRI studies.	R Cabeza, L Nyberg	J Cogn Neurosci	2000	10769304	No
2847	1186	1186.0	40.98	41.0	The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension.	N M Kaplan	Arch Intern Med	1989	2662932	No
2848	1186	1186.0	47.18	47.2	Bone "mass" and the "mechanostat": a proposal.	H M Frost	Anat Rec	1987	3688455	Yes
2849	1186	1186.0	27.4	27.4	Production of recombinant protein therapeutics in cultivated mammalian cells.	Florian M Wurm	Nat Biotechnol	2004	15529164	No
2850	2371	1185.5	70.64	35.3	Recent advances in the phencyclidine model of schizophrenia.	D C Javitt, S R Zukin	Am J Psychiatry	1991	1654746	No
2851	2371	1185.5	95.72	47.9	The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure.	R Näätänen, T Picton	Psychophysiology	1987	3615753	Yes
2852	1185	1185.0	48.57	48.6	Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs).	S Safe	Crit Rev Toxicol	1990	2124811	No
2853	1185	1185.0	41.31	41.3	Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds.	A J Alpert	J Chromatogr	1990	2324207	Yes
2854	1185	1185.0	36.12	36.1	The mysteries of lipoprotein(a).	G Utermann	Science	1989	2530631	No
2855	1185	1185.0	32.46	32.5	Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena.	U Mitzdorf	Physiol Rev	1985	3880898	No
2856	1185	1185.0	32.95	33.0	Diversity of group types, regulation, and function of phospholipase A2.	E A Dennis	J Biol Chem	1994	8175726	No
2857	3554	1184.7	112.94	37.6	Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS.	B K Matuszewski, M L Constanzer, C M Chavez-Eng	Anal Chem	2003	12964746	Yes
2858	2369	1184.5	66.62	33.3	Ageing and Parkinson's disease: substantia nigra regional selectivity.	J M Fearnley, A J Lees	Brain	1991	1933245	Yes
2859	16583	1184.5	358.51	25.6	Crystallography & NMR system: A new software suite for macromolecular structure determination.	A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L Warren	Acta Crystallogr D Biol Crystallogr	1998	9757107	Yes
2860	2369	1184.5	52.85	26.4	Toll-like receptors in innate immunity.	Kiyoshi Takeda, Shizuo Akira	Int Immunol	2005	15585605	No
2861	1184	1184.0	34.69	34.7	Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes.	W Sieghart	Pharmacol Rev	1995	7568326	No
2862	1184	1184.0	28.11	28.1	Matrix proteoglycans: from molecular design to cellular function.	R V Iozzo	Annu Rev Biochem	1998	9759499	No
2863	1184	1184.0	25.64	25.6	Assortative mixing in networks.	M E J Newman	Phys Rev Lett	2002	12443515	Yes
2864	1184	1184.0	29.45	29.4	Electrochemiluminescence (ECL).	Mark M Richter	Chem Rev	2004	15186186	No
2865	1184	1184.0	32.15	32.1	Persister cells, dormancy and infectious disease.	Kim Lewis	Nat Rev Microbiol	2007	17143318	No
2866	1184	1184.0	34.11	34.1	Water as an active constituent in cell biology.	Philip Ball	Chem Rev	2008	18095715	No
2867	1184	1184.0	0.0	0.0	Histological demonstration of mucin after periodic acid.	J F A McMANUS	Nature	1946	20995486	Yes
2868	1183	1183.0	33.55	33.5	Papillary and follicular thyroid carcinoma.	M J Schlumberger	N Engl J Med	1998	9445411	No
2869	1183	1183.0	26.61	26.6	Neurobiology of Pavlovian fear conditioning.	S Maren	Annu Rev Neurosci	2001	11520922	No
2870	1183	1183.0	27.95	27.9	Optical microcavities.	Kerry J Vahala	Nature	2003	12917698	Yes
2871	1182	1182.0	19.94	19.9	Mitotic kinases as regulators of cell division and its checkpoints.	E A Nigg	Nat Rev Mol Cell Biol	2001	11413462	No
2872	1182	1182.0	30.27	30.3	Neural systems for recognizing emotion.	Ralph Adolphs	Curr Opin Neurobiol	2002	12015233	No
2873	1182	1182.0	33.97	34.0	Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis.	P Vestergaard	Osteoporos Int	2007	17068657	No
2874	1182	1182.0	39.73	39.7	Tumor delivery of macromolecular drugs based on the EPR effect.	Vladimir Torchilin	Adv Drug Deliv Rev	2011	20304019	No
2875	1181	1181.0	43.59	43.6	The P300 wave of the human event-related potential.	T W Picton	J Clin Neurophysiol	1992	1464675	No
2876	10624	1180.4	354.06	39.3	A novel potent vasoconstrictor peptide produced by vascular endothelial cells.	M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T Masaki	Nature	1988	2451132	Yes
2877	14162	1180.2	641.9	53.5	Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.	Sue Richards, Nazneen Aziz, Sherri Bale, David Bick, Soma Das, Julie Gastier-Foster, Wayne W Grody, Madhuri Hegde, Elaine Lyon, Elaine Spector, Karl Voelkerding, Heidi L Rehm	Genet Med	2015	25741868	No
2878	1180	1180.0	28.38	28.4	Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis.	R Balfour Sartor	Nat Clin Pract Gastroenterol Hepatol	2006	16819502	No
2879	2359	1179.5	61.7	30.9	Hydrogels for tissue engineering: scaffold design variables and applications.	Jeanie L Drury, David J Mooney	Biomaterials	2003	12922147	No
2880	4718	1179.5	213.64	53.4	Progressive statistics for studies in sports medicine and exercise science.	William G Hopkins, Stephen W Marshall, Alan M Batterham, Juri Hanin	Med Sci Sports Exerc	2009	19092709	No
2881	1179	1179.0	0.0	0.0	Nontuberculous mycobacteria and associated diseases.	E Wolinsky	Am Rev Respir Dis	1979	369415	No
2882	1179	1179.0	36.87	36.9	Delirium in older persons.	Sharon K Inouye	N Engl J Med	2006	16540616	No
2883	2357	1178.5	0.0	0.0	Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses.	R B Gustilo, J T Anderson	J Bone Joint Surg Am	1976	773941	Yes
2884	4714	1178.5	128.52	32.1	Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond.	Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S Vasan	Stat Med	2008	17569110	Yes
2885	2357	1178.5	75.47	37.7	Insights into the regulation of protein abundance from proteomic and transcriptomic analyses.	Christine Vogel, Edward M Marcotte	Nat Rev Genet	2012	22411467	No
2886	1178	1178.0	21.57	21.6	Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes.	D Hanahan	Nature	1985	2986015	Yes
2887	1178	1178.0	31.17	31.2	Q-ball imaging.	David S Tuch	Magn Reson Med	2004	15562495	Yes
2888	1178	1178.0	37.31	37.3	Understanding diagnostic tests 3: Receiver operating characteristic curves.	Anthony K Akobeng	Acta Paediatr	2007	17376185	No
2889	2356	1178.0	77.85	38.9	DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI.	Yan Chao-Gan, Zang Yu-Feng	Front Syst Neurosci	2010	20577591	Yes
2890	2355	1177.5	94.89	47.4	Rapid procedure for detection and isolation of large and small plasmids.	C I Kado, S T Liu	J Bacteriol	1981	7009583	Yes
2891	3532	1177.3	72.35	24.1	Cellular survival: a play in three Akts.	S R Datta, A Brunet, M E Greenberg	Genes Dev	1999	10579998	No
2892	1177	1177.0	39.28	39.3	Interleukin-1 and the pathogenesis of the acute-phase response.	C A Dinarello	N Engl J Med	1984	6208485	No
2893	2354	1177.0	63.77	31.9	A neurotrophic model for stress-related mood disorders.	Ronald S Duman, Lisa M Monteggia	Biol Psychiatry	2006	16631126	No
2894	1177	1177.0	34.82	34.8	Species concepts and species delimitation.	Kevin De Queiroz	Syst Biol	2007	18027281	Yes
2895	2352	1176.0	0.0	0.0	The low-density lipoprotein pathway and its relation to atherosclerosis.	J L Goldstein, M S Brown	Annu Rev Biochem	1977	197883	No
2896	1176	1176.0	26.09	26.1	The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression.	S J Collins	Blood	1987	3311197	No
2897	1176	1176.0	19.28	19.3	Themes and variations on ubiquitylation.	A M Weissman	Nat Rev Mol Cell Biol	2001	11265246	No
2898	1176	1176.0	31.8	31.8	Thermo- and pH-responsive polymers in drug delivery.	Dirk Schmaljohann	Adv Drug Deliv Rev	2006	17125884	No
2899	2350	1175.0	62.47	31.2	Biology of incretins: GLP-1 and GIP.	Laurie L Baggio, Daniel J Drucker	Gastroenterology	2007	17498508	No
2900	4699	1174.8	135.44	33.9	Image quality assessment: from error visibility to structural similarity.	Zhou Wang, Alan Conrad Bovik, Hamid Rahim Sheikh, Eero P Simoncelli	IEEE Trans Image Process	2004	15376593	Yes
2901	1174	1174.0	24.85	24.9	Nucleic acid junctions and lattices.	N C Seeman	J Theor Biol	1982	6188926	Yes
2902	1174	1174.0	52.21	52.2	Presynaptic regulation of the release of catecholamines.	S Z Langer	Pharmacol Rev	1980	6267618	Yes
2903	1174	1174.0	20.71	20.7	Stem cells: units of development, units of regeneration, and units in evolution.	I L Weissman	Cell	2000	10647940	No
2904	1174	1174.0	0.0	0.0	Notes on continuous stochastic phenomena.	P A P Moran	Biometrika	1950	15420245	Yes
2905	1174	1174.0	30.37	30.4	Functionalized acenes and heteroacenes for organic electronics.	John E Anthony	Chem Rev	2006	17165682	Yes
2906	1174	1174.0	69.25	69.2	Neutrophil extracellular traps in immunity and disease.	Venizelos Papayannopoulos	Nat Rev Immunol	2018	28990587	No
2907	2347	1173.5	80.87	40.4	Social conditions as fundamental causes of disease.	B G Link, J Phelan	J Health Soc Behav	1995	7560851	No
2908	1173	1173.0	52.77	52.8	Environmentally induced oxidative stress in aquatic animals.	Volodymyr I Lushchak	Aquat Toxicol	2011	21074869	No
2909	2345	1172.5	49.27	24.6	Atherosclerosis. the road ahead.	C K Glass, J L Witztum	Cell	2001	11239408	No
2910	2345	1172.5	60.62	30.3	Epidemiology of Parkinson's disease.	Lonneke M L de Lau, Monique M B Breteler	Lancet Neurol	2006	16713924	No
2911	3517	1172.3	72.76	24.3	Toll-like receptors: critical proteins linking innate and acquired immunity.	S Akira, K Takeda, T Kaisho	Nat Immunol	2001	11477402	No
2912	2344	1172.0	0.0	0.0	Radiological demarcation of cemented sockets in total hip replacement.	J G DeLee, J Charnley	Clin Orthop Relat Res	1976	991504	Yes
2913	1172	1172.0	45.28	45.3	Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes.	H V Gelboin	Physiol Rev	1980	7001511	No
2914	1172	1172.0	30.01	30.0	Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.	G Boden	Diabetes	1997	8971073	No
2915	1172	1172.0	0.0	0.0	A chemical method for the determination of oestriol, oestrone and oestradiol in human urine.	J B Brown	Biochem J	1955	14389222	Yes
2916	3515	1171.7	0.0	0.0	The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects.	G Blessed, B E Tomlinson, M Roth	Br J Psychiatry	1968	5662937	Yes
2917	5856	1171.2	190.99	38.2	Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity.	D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L Witztum	N Engl J Med	1989	2648148	No
2918	1171	1171.0	142.46	142.5	COVID-19 and African Americans.	Clyde W Yancy	JAMA	2020	32293639	Yes
2919	2341	1170.5	58.9	29.4	Hydrogels for tissue engineering.	K Y Lee, D J Mooney	Chem Rev	2001	11710233	No
2920	1170	1170.0	34.7	34.7	The structure of common mental disorders.	R F Krueger	Arch Gen Psychiatry	1999	10530634	Yes
2921	1170	1170.0	32.77	32.8	Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective.	Antoine Bechara	Nat Neurosci	2005	16251988	No
2922	2339	1169.5	50.76	25.4	Lymphocyte homing and homeostasis.	E C Butcher, L J Picker	Science	1996	8600538	No
2923	2339	1169.5	94.28	47.1	Liposomal drug delivery systems: from concept to clinical applications.	Theresa M Allen, Pieter R Cullis	Adv Drug Deliv Rev	2013	23036225	No
2924	4675	1168.8	0.0	0.0	Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm.	L A Papile, J Burstein, R Burstein, H Koffler	J Pediatr	1978	305471	Yes
2925	4675	1168.8	136.44	34.1	Place navigation impaired in rats with hippocampal lesions.	R G Morris, P Garrud, J N Rawlins, J O'Keefe	Nature	1982	7088155	Yes
2926	1168	1168.0	0.0	0.0	Presynaptic regulation of catecholamine release.	S Z Langer	Biochem Pharmacol	1974	4617579	No
2927	2336	1168.0	49.09	24.5	NF-kappaB: linking inflammation and immunity to cancer development and progression.	Michael Karin, Florian R Greten	Nat Rev Immunol	2005	16175180	No
2928	2336	1168.0	79.84	39.9	Tumor-associated macrophages: from mechanisms to therapy.	Roy Noy, Jeffrey W Pollard	Immunity	2014	25035953	No
2929	4668	1167.0	109.63	27.4	Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.	G L Wang, B H Jiang, E A Rue, G L Semenza	Proc Natl Acad Sci U S A	1995	7539918	Yes
2930	1167	1167.0	25.38	25.4	An overview of epithelio-mesenchymal transformation.	E D Hay	Acta Anat (Basel)	1995	8714286	No
2931	1167	1167.0	25.5	25.5	Sustainable hydrogen production.	John A Turner	Science	2004	15310892	Yes
2932	3501	1167.0	200.59	66.9	Radiomics: Images Are More than Pictures, They Are Data.	Robert J Gillies, Paul E Kinahan, Hedvig Hricak	Radiology	2016	26579733	Yes
2933	3499	1166.3	0.0	0.0	Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels.	A L Shapiro, E Viñuela, J V Maizel	Biochem Biophys Res Commun	1967	4861258	Yes
2934	1166	1166.0	73.08	73.1	Impingement lesions.	C S Neer	Clin Orthop Relat Res	1983	6825348	Yes
2935	2332	1166.0	48.75	24.4	Toll-like receptors in the induction of the innate immune response.	A Aderem, R J Ulevitch	Nature	2000	10963608	No
2936	2332	1166.0	69.82	34.9	Natural products as sources of new drugs over the last 25 years.	David J Newman, Gordon M Cragg	J Nat Prod	2007	17309302	No
2937	3497	1165.7	119.28	39.8	Job burnout.	C Maslach, W B Schaufeli, M P Leiter	Annu Rev Psychol	2001	11148311	Yes
2938	1165	1165.0	28.26	28.3	Plant salt tolerance.	J K Zhu	Trends Plant Sci	2001	11173290	Yes
2939	1164	1164.0	0.0	0.0	Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method.	K Satoh	Clin Chim Acta	1978	719890	Yes
2940	1164	1164.0	33.63	33.6	Regulation of glutathione synthesis.	Shelly C Lu	Mol Aspects Med	2009	18601945	No
2941	1164	1164.0	25.84	25.8	Hypoxia, HIF1 and glucose metabolism in the solid tumour.	Nicholas C Denko	Nat Rev Cancer	2008	19143055	No
2942	4653	1163.2	132.15	33.0	Toxic potential of materials at the nanolevel.	Andre Nel, Tian Xia, Lutz Mädler, Ning Li	Science	2006	16456071	No
2943	1163	1163.0	26.04	26.0	Cadherins: a molecular family important in selective cell-cell adhesion.	M Takeichi	Annu Rev Biochem	1990	2197976	No
2944	1163	1163.0	22.17	22.2	Contingent genetic regulatory events in T lymphocyte activation.	G R Crabtree	Science	1989	2783497	Yes
2945	1163	1163.0	28.29	28.3	Metabolism and functions of glutathione in brain.	R Dringen	Prog Neurobiol	2000	10880854	No
2946	1163	1163.0	30.65	30.6	Physiology and pathophysiology of purinergic neurotransmission.	Geoffrey Burnstock	Physiol Rev	2007	17429044	No
2947	3486	1162.0	0.0	0.0	Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.	A DeLean, P J Munson, D Rodbard	Am J Physiol	1978	686171	Yes
2948	1162	1162.0	0.0	0.0	A sensitive method for the assay of 5-hydroxytryptamine.	J R Vane	Br J Pharmacol Chemother	1957	13460242	Yes
2949	1162	1162.0	37.39	37.4	Socioeconomic status and obesity.	Lindsay McLaren	Epidemiol Rev	2007	17478442	No
2950	3485	1161.7	68.42	22.8	Exosomes: composition, biogenesis and function.	Clotilde Théry, Laurence Zitvogel, Sebastian Amigorena	Nat Rev Immunol	2002	12154376	No
2951	2323	1161.5	64.84	32.4	Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.	R G Phillips, J E LeDoux	Behav Neurosci	1992	1590953	Yes
2952	2323	1161.5	0.0	0.0	Quantitative determination of serum triglycerides by the use of enzymes.	G Bucolo, H David	Clin Chem	1973	4703655	Yes
2953	2322	1161.0	0.0	0.0	Solubilization of membranes by detergents.	A Helenius, K Simons	Biochim Biophys Acta	1975	1091302	No
2954	1161	1161.0	41.56	41.6	Physiological implications of hydrogen sulfide: a whiff exploration that blossomed.	Rui Wang	Physiol Rev	2012	22535897	No
2955	8121	1160.1	242.25	34.6	Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.	H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E Marsh	Stroke	1993	7678184	Yes
2956	3480	1160.0	70.3	23.4	Predicting coiled coils from protein sequences.	A Lupas, M Van Dyke, J Stock	Science	1991	2031185	Yes
2957	1160	1160.0	0.0	0.0	Biogenic amines and the states of sleep.	M Jouvet	Science	1969	4303225	No
2958	1160	1160.0	23.45	23.4	Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy.	Harold F Dvorak	J Clin Oncol	2002	12409337	No
2959	1160	1160.0	30.04	30.0	TNF-mediated inflammatory disease.	J R Bradley	J Pathol	2008	18161752	No
2960	1159	1159.0	30.44	30.4	Pathogenesis of dengue: challenges to molecular biology.	S B Halstead	Science	1988	3277268	No
2961	1159	1159.0	0.0	0.0	RNA metabolism in the HeLa cell nucleus.	S Penman	J Mol Biol	1966	5961144	Yes
2962	1159	1159.0	0.0	0.0	Voluntary strength and fatigue.	P A Merton	J Physiol	1954	13152698	Yes
2963	1159	1159.0	41.06	41.1	Function and information content of DNA methylation.	Dirk Schübeler	Nature	2015	25592537	No
2964	8107	1158.1	162.63	23.2	Exploration, normalization, and summaries of high density oligonucleotide array probe level data.	Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P Speed	Biostatistics	2003	12925520	Yes
2965	1158	1158.0	0.0	0.0	Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle.	J O Holloszy	J Biol Chem	1967	4290225	Yes
2966	2316	1158.0	0.0	0.0	Plasminogen: purification from human plasma by affinity chromatography.	D G Deutsch, E T Mertz	Science	1970	5475635	Yes
2967	1158	1158.0	33.98	34.0	Electrochemical glucose biosensors.	Joseph Wang	Chem Rev	2008	18154363	No
2968	1157	1157.0	0.0	0.0	6-Hydroxy-dopamine induced degeneration of central monoamine neurons.	U Ungerstedt	Eur J Pharmacol	1968	5718510	Yes
2969	1157	1157.0	42.57	42.6	Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants.	R W Bohannon	Age Ageing	1997	9143432	Yes
2970	1157	1157.0	32.23	32.2	The induction of pain: an integrative review.	M J Millan	Prog Neurobiol	1999	9987804	No
2971	1157	1157.0	0.0	0.0	On the law of effect.	R J Herrnstein	J Exp Anal Behav	1970	16811440	Yes
2972	2313	1156.5	86.65	43.3	Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal.	H Esterbauer, K H Cheeseman	Methods Enzymol	1990	2233308	Yes
2973	2313	1156.5	45.35	22.7	Multiple nuclear factors interact with the immunoglobulin enhancer sequences.	R Sen, D Baltimore	Cell	1986	3091258	Yes
2974	5781	1156.2	232.9	46.6	Fsl.	Mark Jenkinson, Christian F Beckmann, Timothy E J Behrens, Mark W Woolrich, Stephen M Smith	Neuroimage	2012	21979382	No
2975	1156	1156.0	0.0	0.0	Selective coronary arteriography. I. A percutaneous transfemoral technic.	M P Judkins	Radiology	1967	6048074	Yes
2976	2312	1156.0	89.08	44.5	Cronbach's alpha.	J M Bland, D G Altman	BMJ	1997	9055718	Yes
2977	3467	1155.7	89.23	29.7	Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya.	C R Woese, O Kandler, M L Wheelis	Proc Natl Acad Sci U S A	1990	2112744	Yes
2978	2311	1155.5	71.44	35.7	A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data.	A Ennaceur, J Delacour	Behav Brain Res	1988	3228475	Yes
2979	2311	1155.5	49.42	24.7	Functions of lipid rafts in biological membranes.	D A Brown, E London	Annu Rev Cell Dev Biol	1998	9891780	No
2980	2311	1155.5	56.76	28.4	Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology.	M E Feder, G E Hofmann	Annu Rev Physiol	1999	10099689	No
2981	2311	1155.5	67.97	34.0	Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications.	Xiaobo Chen, Samuel S Mao	Chem Rev	2007	17590053	Yes
2982	1155	1155.0	0.0	0.0	Pathologic anatomy of the pancreas in juvenile diabetes mellitus.	W Gepts	Diabetes	1965	5318831	Yes
2983	1155	1155.0	22.21	22.2	Microarray data normalization and transformation.	John Quackenbush	Nat Genet	2002	12454644	No
2984	1155	1155.0	55.86	55.9	1,500 scientists lift the lid on reproducibility.	Monya Baker	Nature	2016	27225100	No
2985	3464	1154.7	0.0	0.0	High resolution two-dimensional electrophoresis of basic as well as acidic proteins.	P Z O'Farrell, H M Goodman, P H O'Farrell	Cell	1977	23215	Yes
2986	3463	1154.3	105.75	35.2	Health benefits of physical activity: the evidence.	Darren E R Warburton, Crystal Whitney Nicol, Shannon S D Bredin	CMAJ	2006	16534088	No
2987	4617	1154.2	108.63	27.2	Base-calling of automated sequencer traces using phred. I. Accuracy assessment.	B Ewing, L Hillier, M C Wendl, P Green	Genome Res	1998	9521921	Yes
2988	1154	1154.0	36.49	36.5	Molecular biology of steroid hormone synthesis.	W L Miller	Endocr Rev	1988	3061784	No
2989	2308	1154.0	100.09	50.0	Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity.	P R Hunter, M A Gaston	J Clin Microbiol	1988	3069867	Yes
2990	2308	1154.0	0.0	0.0	Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice.	J D McGhee, P H von Hippel	J Mol Biol	1974	4416620	Yes
2991	1154	1154.0	34.94	34.9	Low-molecular-weight heparins.	J I Weitz	N Engl J Med	1997	9278467	No
2992	2308	1154.0	46.83	23.4	Community structure in social and biological networks.	M Girvan, M E J Newman	Proc Natl Acad Sci U S A	2002	12060727	No
2993	1153	1153.0	32.01	32.0	Normalization of cell responses in cat striate cortex.	D J Heeger	Vis Neurosci	1992	1504027	Yes
2994	2306	1153.0	41.94	21.0	Hedgehog signaling in animal development: paradigms and principles.	P W Ingham, A P McMahon	Genes Dev	2001	11731473	No
2995	2306	1153.0	109.98	55.0	Sex differences in immune responses.	Sabra L Klein, Katie L Flanagan	Nat Rev Immunol	2016	27546235	No
2996	2305	1152.5	62.17	31.1	Chlorophyll fluorescence--a practical guide.	K Maxwell, G N Johnson	J Exp Bot	2000	10938857	No
2997	5762	1152.4	195.24	39.0	Posttraumatic stress disorder in the National Comorbidity Survey.	R C Kessler, A Sonnega, E Bromet, M Hughes, C B Nelson	Arch Gen Psychiatry	1995	7492257	Yes
2998	2304	1152.0	0.0	0.0	Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme.	A Warshel, M Levitt	J Mol Biol	1976	985660	Yes
2999	2304	1152.0	44.14	22.1	Dynamic instability of microtubule growth.	T Mitchison, M Kirschner	Nature	1984	6504138	Yes
3000	1152	1152.0	29.66	29.7	Disorders of iron metabolism.	N C Andrews	N Engl J Med	1999	10607817	No
3001	1152	1152.0	32.88	32.9	Targeting recovery: priorities of the spinal cord-injured population.	Kim D Anderson	J Neurotrauma	2004	15672628	Yes
3002	2304	1152.0	71.97	36.0	Inflammatory mechanisms in obesity.	Margaret F Gregor, Gökhan S Hotamisligil	Annu Rev Immunol	2011	21219177	No
3003	1152	1152.0	61.39	61.4	International classification of sleep disorders-third edition: highlights and modifications.	Michael J Sateia	Chest	2014	25367475	No
3004	1151	1151.0	45.42	45.4	Geriatric Depression Scale.	J A Yesavage	Psychopharmacol Bull	1988	3249773	Yes
3005	1151	1151.0	105.4	105.4	The analysis of errors in orthodontic measurements.	W J Houston	Am J Orthod	1983	6573846	Yes
3006	2300	1150.0	0.0	0.0	Growth of a rat neuroblastoma cell line in serum-free supplemented medium.	J E Bottenstein, G H Sato	Proc Natl Acad Sci U S A	1979	284369	Yes
3007	1150	1150.0	34.56	34.6	Effect of anoxia on ion distribution in the brain.	A J Hansen	Physiol Rev	1985	3880896	No
3008	2300	1150.0	48.17	24.1	The mammalian unfolded protein response.	Martin Schröder, Randal J Kaufman	Annu Rev Biochem	2005	15952902	No
3009	3449	1149.7	77.51	25.8	Hepatocellular carcinoma.	Josep M Llovet, Andrew Burroughs, Jordi Bruix	Lancet	2003	14667750	No
3010	2299	1149.5	72.26	36.1	Plasmonics for improved photovoltaic devices.	Harry A Atwater, Albert Polman	Nat Mater	2010	20168344	Yes
3011	1149	1149.0	23.83	23.8	Apoptosis in neurodegenerative disorders.	M P Mattson	Nat Rev Mol Cell Biol	2000	11253364	No
3012	2297	1148.5	0.0	0.0	Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.	R W Butcher, E W Sutherland	J Biol Chem	1962	13875173	Yes
3013	1148	1148.0	0.0	0.0	An approach for the treatment of penile carcinoma.	R M Cabanas	Cancer	1977	837331	Yes
3014	1148	1148.0	34.02	34.0	Determinants of tumor blood flow: a review.	R K Jain	Cancer Res	1988	3282647	No
3015	1148	1148.0	30.28	30.3	The neurobiology of stress: from serendipity to clinical relevance.	B S McEwen	Brain Res	2000	11119695	No
3016	1148	1148.0	48.72	48.7	The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults.	L S Radloff	J Youth Adolesc	1991	24265004	Yes
3017	1147	1147.0	0.0	0.0	Radioimmunological determination of human C-peptide in serum.	L G Heding	Diabetologia	1975	1239396	Yes
3018	1147	1147.0	34.15	34.1	Analyzing the mosaic structure of genes.	J M Smith	J Mol Evol	1992	1556748	No
3019	1147	1147.0	0.0	0.0	Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol.	D B Clewell	J Bacteriol	1972	4336693	Yes
3020	1147	1147.0	22.18	22.2	Mechanisms and consequences of activation of protein kinase B/Akt.	J Downward	Curr Opin Cell Biol	1998	9561851	No
3021	3441	1147.0	109.87	36.6	Qualitative research in health care. Analysing qualitative data.	C Pope, S Ziebland, N Mays	BMJ	2000	10625273	No
3022	1147	1147.0	31.09	31.1	Akaike's information criterion in generalized estimating equations.	W Pan	Biometrics	2001	11252586	Yes
3023	1147	1147.0	25.22	25.2	The myofibroblast in wound healing and fibrocontractive diseases.	G Gabbiani	J Pathol	2003	12845617	No
3024	1147	1147.0	0.0	0.0	Preliminary Trial Of Carisoprodol In Multiple Sclerosis.	B Ashworth	Practitioner	1964	14143329	Yes
3025	1147	1147.0	0.0	0.0	Diffusion-in-gel methods for immunological analysis. II.	O Ouchterlony	Prog Allergy	1962	14482809	Yes
3026	2293	1146.5	51.73	25.9	Adaptive protein evolution at the Adh locus in Drosophila.	J H McDonald, M Kreitman	Nature	1991	1904993	Yes
3027	2293	1146.5	46.49	23.2	A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells.	N C Andrews, D V Faller	Nucleic Acids Res	1991	2041787	Yes
3028	2292	1146.0	71.25	35.6	Role of oxidized low density lipoprotein in atherogenesis.	J L Witztum, D Steinberg	J Clin Invest	1991	1752940	No
3029	1146	1146.0	31.51	31.5	Pharmacology of cannabinoid CB1 and CB2 receptors.	R G Pertwee	Pharmacol Ther	1997	9336020	No
3030	6873	1145.5	236.12	39.4	The occurrence of sleep-disordered breathing among middle-aged adults.	T Young, M Palta, J Dempsey, J Skatrud, S Weber, S Badr	N Engl J Med	1993	8464434	Yes
3031	2290	1145.0	48.14	24.1	Sequence logos: a new way to display consensus sequences.	T D Schneider, R M Stephens	Nucleic Acids Res	1990	2172928	Yes
3032	1145	1145.0	32.07	32.1	DNA topoisomerases.	M Gellert	Annu Rev Biochem	1981	6267993	No
3033	2290	1145.0	66.77	33.4	Excitatory amino acids as a final common pathway for neurologic disorders.	S A Lipton, P A Rosenberg	N Engl J Med	1994	7905600	No
3034	1145	1145.0	26.83	26.8	Amyloid, the presenilins and Alzheimer's disease.	J Hardy	Trends Neurosci	1997	9106355	No
3035	1145	1145.0	0.0	0.0	A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces.	M G Buonocore	J Dent Res	1955	13271655	Yes
3036	2290	1145.0	52.52	26.3	Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis.	Jing Yang, Robert A Weinberg	Dev Cell	2008	18539112	No
3037	1145	1145.0	22.43	22.4	ChIP-seq: advantages and challenges of a maturing technology.	Peter J Park	Nat Rev Genet	2009	19736561	No
3038	1144	1144.0	22.68	22.7	A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development.	Xuemei Chen	Science	2004	12893888	Yes
3039	2288	1144.0	56.2	28.1	Principles of bioactive lipid signalling: lessons from sphingolipids.	Yusuf A Hannun, Lina M Obeid	Nat Rev Mol Cell Biol	2008	18216770	No
3040	1144	1144.0	39.53	39.5	Phenylpropanoid biosynthesis.	Thomas Vogt	Mol Plant	2010	20035037	No
3041	5719	1143.8	281.43	56.3	Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee.	N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W Stitt	J Rheumatol	1988	3068365	Yes
3042	3430	1143.3	0.0	0.0	Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.	G M Wahl, M Stern, G R Stark	Proc Natl Acad Sci U S A	1979	291033	Yes
3043	2286	1143.0	76.12	38.1	Physiological parameters in laboratory animals and humans.	B Davies, T Morris	Pharm Res	1993	8378254	No
3044	1143	1143.0	27.65	27.6	A tension-based theory of morphogenesis and compact wiring in the central nervous system.	D C Van Essen	Nature	1997	9002514	Yes
3045	1143	1143.0	24.28	24.3	Stem cells in the central nervous system.	R McKay	Science	1997	9082987	No
3046	1143	1143.0	0.0	0.0	Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye.	P B Medawar	Br J Exp Pathol	1948	18865105	Yes
3047	1143	1143.0	0.0	0.0	A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations.	R D Hotchkiss	Arch Biochem	1948	18921848	Yes
3048	2285	1142.5	59.01	29.5	An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance.	Gary Aston-Jones, Jonathan D Cohen	Annu Rev Neurosci	2005	16022602	No
3049	1142	1142.0	0.0	0.0	Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb.	J Altman	J Comp Neurol	1969	5361244	Yes
3050	1142	1142.0	0.0	0.0	The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis.	R E Hope-Simpson	Proc R Soc Med	1965	14267505	Yes
3051	9132	1141.5	244.34	30.5	A method and server for predicting damaging missense mutations.	Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R Sunyaev	Nat Methods	2010	20354512	Yes
3052	1141	1141.0	28.42	28.4	Automatic quantitation of localized in vivo 1H spectra with LCModel.	S W Provencher	NMR Biomed	2001	11410943	Yes
3053	1141	1141.0	23.86	23.9	Fibrotic disease and the T(H)1/T(H)2 paradigm.	Thomas A Wynn	Nat Rev Immunol	2004	15286725	No
3054	1141	1141.0	34.42	34.4	MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship.	Amy E Pasquinelli	Nat Rev Genet	2012	22411466	No
3055	4563	1140.8	103.14	25.8	Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.	J E Walker, M Saraste, M J Runswick, N J Gay	EMBO J	1982	6329717	Yes
3056	2281	1140.5	67.1	33.5	Nitric oxide synthases in mammals.	R G Knowles, S Moncada	Biochem J	1994	7510950	No
3057	4561	1140.2	111.53	27.9	Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites.	H Nielsen, J Engelbrecht, S Brunak, G von Heijne	Protein Eng	1997	9051728	Yes
3058	1140	1140.0	0.0	0.0	Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase.	R J Pennington	Biochem J	1961	13734134	Yes
3059	1140	1140.0	28.18	28.2	Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science.	Christof M Niemeyer	Angew Chem Int Ed Engl	2001	29712109	No
3060	4558	1139.5	89.16	22.3	Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.	L Alexopoulou, A C Holt, R Medzhitov, R A Flavell	Nature	2001	11607032	Yes
3061	2279	1139.5	43.94	22.0	NF-kappaB at the crossroads of life and death.	Michael Karin, Anning Lin	Nat Immunol	2002	11875461	No
3062	3417	1139.0	172.01	57.3	Assessing coping strategies: a theoretically based approach.	C S Carver, M F Scheier, J K Weintraub	J Pers Soc Psychol	1989	2926629	Yes
3063	1139	1139.0	44.88	44.9	Freezing of living cells: mechanisms and implications.	P Mazur	Am J Physiol	1984	6383068	No
3064	2278	1139.0	59.06	29.5	Statistical tests of neutrality of mutations.	Y X Fu, W H Li	Genetics	1993	8454210	Yes
3065	3416	1138.7	137.8	45.9	Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis.	Christopher K Prier, Danica A Rankic, David W C MacMillan	Chem Rev	2013	23509883	No
3066	2277	1138.5	70.36	35.2	Stochastic relaxation, gibbs distributions, and the bayesian restoration of images.	S Geman, D Geman	IEEE Trans Pattern Anal Mach Intell	1984	22499653	Yes
3067	2277	1138.5	88.52	44.3	Role of the microbiota in immunity and inflammation.	Yasmine Belkaid, Timothy W Hand	Cell	2014	24679531	No
3068	1138	1138.0	0.0	0.0	Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release.	S Z Langer	Br J Pharmacol	1977	20190	No
3069	1138	1138.0	31.1	31.1	Diseases of the mitochondrial DNA.	D C Wallace	Annu Rev Biochem	1992	1497308	No
3070	1138	1138.0	40.6	40.6	Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes.	W A Catterall	Annu Rev Pharmacol Toxicol	1980	6247957	No
3071	1138	1138.0	35.13	35.1	The somatic marker hypothesis and the possible functions of the prefrontal cortex.	A R Damasio	Philos Trans R Soc Lond B Biol Sci	1996	8941953	No
3072	1138	1138.0	21.99	22.0	The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities.	Y Yarden	Eur J Cancer	2001	11597398	No
3073	1138	1138.0	0.0	0.0	Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig.	G D Winter	Nature	1962	14007593	Yes
3074	1138	1138.0	29.83	29.8	Molecular genetics of colorectal cancer.	Eric R Fearon	Annu Rev Pathol	2011	21090969	No
3075	3411	1137.0	127.58	42.5	Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research.	C J Caspersen, K E Powell, G M Christenson	Public Health Rep	1985	3920711	Yes
3076	1137	1137.0	0.0	0.0	Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells.	A B Stavitsky	J Immunol	1954	13163409	Yes
3077	2273	1136.5	60.75	30.4	Analysis of gene control signals by DNA fusion and cloning in Escherichia coli.	M J Casadaban, S N Cohen	J Mol Biol	1980	6997493	Yes
3078	3409	1136.3	0.0	0.0	Cytochemical identification of monocytes and granulocytes.	L T Yam, C Y Li, W H Crosby	Am J Clin Pathol	1971	5549896	Yes
3079	4545	1136.2	177.33	44.3	The chemistry and applications of metal-organic frameworks.	Hiroyasu Furukawa, Kyle E Cordova, Michael O'Keeffe, Omar M Yaghi	Science	2013	23990564	Yes
3080	1136	1136.0	25.36	25.4	G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry.	Jeffery T Davis	Angew Chem Int Ed Engl	2004	14755695	No
3081	1136	1136.0	23.31	23.3	Protein tyrosine phosphatases: from genes, to function, to disease.	Nicholas K Tonks	Nat Rev Mol Cell Biol	2006	17057753	No
3082	2271	1135.5	53.78	26.9	Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival.	Josep M Llovet, Jordi Bruix	Hepatology	2003	12540794	No
3083	1135	1135.0	33.76	33.8	A human model of gastric carcinogenesis.	P Correa	Cancer Res	1988	3288329	No
3084	1135	1135.0	0.0	0.0	An improved fluorometric assay for DNA.	R T Hinegardner	Anal Biochem	1971	5544593	Yes
3085	1135	1135.0	0.0	0.0	Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone.	A R Midgley	Endocrinology	1966	5950482	Yes
3086	1135	1135.0	34.94	34.9	Context, time, and memory retrieval in the interference paradigms of Pavlovian learning.	M E Bouton	Psychol Bull	1993	8346330	No
3087	1135	1135.0	37.65	37.6	Checklists for improving rigour in qualitative research: a case of the tail wagging the dog?	R S Barbour	BMJ	2001	11337448	No
3088	5671	1134.2	245.73	49.1	The Phyre2 web portal for protein modeling, prediction and analysis.	Lawrence A Kelley, Stefans Mezulis, Christopher M Yates, Mark N Wass, Michael J E Sternberg	Nat Protoc	2015	25950237	Yes
3089	1134	1134.0	33.53	33.5	Reducing children's television viewing to prevent obesity: a randomized controlled trial.	T N Robinson	JAMA	1999	10546696	Yes
3090	1134	1134.0	25.43	25.4	Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial.	H J Dargie	Lancet	2001	11356434	Yes
3091	2268	1134.0	0.0	0.0	Active transport of sodium as the source of electric current in the short-circuited isolated frog skin.	H H Ussing, K Zerahn	Acta Physiol Scand	1951	14868510	Yes
3092	1134	1134.0	35.06	35.1	Platelet-rich plasma: evidence to support its use.	Robert E Marx	J Oral Maxillofac Surg	2004	15085519	No
3093	1134	1134.0	40.02	40.0	Volumetric modulated arc therapy: IMRT in a single gantry arc.	Karl Otto	Med Phys	2008	18293586	Yes
3094	3402	1134.0	119.13	39.7	Hepatocellular carcinoma.	Alejandro Forner, Josep M Llovet, Jordi Bruix	Lancet	2012	22353262	No
3095	1134	1134.0	89.25	89.2	Toward understanding the origin and evolution of cellular organisms.	Minoru Kanehisa	Protein Sci	2019	31441146	No
3096	1133	1133.0	30.33	30.3	The emotional dog and its rational tail: a social intuitionist approach to moral judgment.	J Haidt	Psychol Rev	2001	11699120	Yes
3097	1133	1133.0	23.21	23.2	Liver regeneration: from myth to mechanism.	Rebecca Taub	Nat Rev Mol Cell Biol	2004	15459664	No
3098	2266	1133.0	96.03	48.0	A typology of reviews: an analysis of 14 review types and associated methodologies.	Maria J Grant, Andrew Booth	Health Info Libr J	2009	19490148	No
3099	3399	1133.0	128.91	43.0	Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles.	Marina Colombo, Graça Raposo, Clotilde Théry	Annu Rev Cell Dev Biol	2014	25288114	No
3100	4531	1132.8	128.46	32.1	Measurement of the elastic properties and intrinsic strength of monolayer graphene.	Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James Hone	Science	2008	18635798	Yes
3101	1132	1132.0	0.0	0.0	Structure of chromatin.	R D Kornberg	Annu Rev Biochem	1977	332067	No
3102	1132	1132.0	33.48	33.5	What is synergy?	M C Berenbaum	Pharmacol Rev	1989	2692037	No
3103	1132	1132.0	47.59	47.6	AliView: a fast and lightweight alignment viewer and editor for large datasets.	Anders Larsson	Bioinformatics	2014	25095880	Yes
3104	3395	1131.7	90.28	30.1	Methods in mammalian autophagy research.	Noboru Mizushima, Tamotsu Yoshimori, Beth Levine	Cell	2010	20144757	Yes
3105	1131	1131.0	28.6	28.6	Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.	I J Fidler	Cancer Res	1990	1698118	Yes
3106	1131	1131.0	33.78	33.8	Unstable angina. A classification.	E Braunwald	Circulation	1989	2752565	Yes
3107	1131	1131.0	35.43	35.4	Strategies of antioxidant defense.	H Sies	Eur J Biochem	1993	7688300	No
3108	1131	1131.0	29.4	29.4	The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices.	R A Jain	Biomaterials	2000	11055295	No
3109	1131	1131.0	35.38	35.4	Sensorimotor integration in human postural control.	R J Peterka	J Neurophysiol	2002	12205132	Yes
3110	1131	1131.0	0.0	0.0	The powerful placebo.	H K Beecher	J Am Med Assoc	1955	13271123	Yes
3111	2260	1130.0	78.39	39.2	The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis.	G P Chrousos, P W Gold	JAMA	1992	1538563	No
3112	1130	1130.0	22.17	22.2	Regulation of transcription by MAP kinase cascades.	R Treisman	Curr Opin Cell Biol	1996	8791420	No
3113	1129	1129.0	41.69	41.7	Omega-3 fatty acids in health and disease and in growth and development.	A P Simopoulos	Am J Clin Nutr	1991	1908631	No
3114	1129	1129.0	26.5	26.5	Neurons with graded response have collective computational properties like those of two-state neurons.	J J Hopfield	Proc Natl Acad Sci U S A	1984	6587342	Yes
3115	1129	1129.0	26.35	26.4	Allelic discrimination using fluorogenic probes and the 5' nuclease assay.	K J Livak	Genet Anal	1999	10084106	Yes
3116	1129	1129.0	31.21	31.2	Leishmaniasis.	B L Herwaldt	Lancet	1999	10513726	No
3117	1129	1129.0	25.26	25.3	How neutrophils kill microbes.	Anthony W Segal	Annu Rev Immunol	2005	15771570	No
3118	2258	1129.0	49.52	24.8	Defining the role of mTOR in cancer.	David A Guertin, David M Sabatini	Cancer Cell	2007	17613433	No
3119	1129	1129.0	51.32	51.3	The global burden of IBD: from 2015 to 2025.	Gilaad G Kaplan	Nat Rev Gastroenterol Hepatol	2015	26323879	No
3120	2257	1128.5	0.0	0.0	Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases.	L M Siegel, K J Monty	Biochim Biophys Acta	1966	5329026	Yes
3121	2256	1128.0	76.61	38.3	Pharmaceuticals and personal care products in the environment: agents of subtle change?	C G Daughton, T A Ternes	Environ Health Perspect	1999	10592150	No
3122	1128	1128.0	26.55	26.6	A likelihood approach to estimating phylogeny from discrete morphological character data.	P O Lewis	Syst Biol	2001	12116640	Yes
3123	2256	1128.0	51.58	25.8	Shape-controlled synthesis of gold and silver nanoparticles.	Yugang Sun, Younan Xia	Science	2002	12481134	Yes
3124	1128	1128.0	36.57	36.6	Clinical practice. Endometriosis.	Linda C Giudice	N Engl J Med	2010	20573927	No
3125	2255	1127.5	58.89	29.4	Humans integrate visual and haptic information in a statistically optimal fashion.	Marc O Ernst, Martin S Banks	Nature	2002	11807554	Yes
3126	2254	1127.0	44.28	22.1	Homeobox genes and axial patterning.	W McGinnis, R Krumlauf	Cell	1992	1346368	No
3127	1127	1127.0	0.0	0.0	pA, a new scale for the measurement of drug antagonism.	H O Schild	Br J Pharmacol Chemother	1947	20258355	Yes
3128	1127	1127.0	34.35	34.4	T follicular helper cell differentiation, function, and roles in disease.	Shane Crotty	Immunity	2014	25367570	No
3129	1126	1126.0	35.63	35.6	Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations.	Ronald A Hites	Environ Sci Technol	2004	14998004	Yes
3130	1126	1126.0	29.53	29.5	The complex role of estrogens in inflammation.	Rainer H Straub	Endocr Rev	2007	17640948	No
3131	1125	1125.0	30.31	30.3	The chromosomal basis of human neoplasia.	J J Yunis	Science	1983	6336310	Yes
3132	1125	1125.0	42.71	42.7	On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture.	D Collen	Thromb Haemost	1980	6450468	No
3133	3375	1125.0	157.31	52.4	Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines.	F Guillemin, C Bombardier, D Beaton	J Clin Epidemiol	1993	8263569	No
3134	2249	1124.5	45.95	23.0	Of mice and not men: differences between mouse and human immunology.	Javier Mestas, Christopher C W Hughes	J Immunol	2004	14978070	No
3135	1124	1124.0	0.0	0.0	Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation.	M M Weiser	J Biol Chem	1973	4698230	Yes
3136	1124	1124.0	42.64	42.6	Molecular aspects of ligand binding to serum albumin.	U Kragh-Hansen	Pharmacol Rev	1981	7027277	No
3137	1124	1124.0	38.24	38.2	beta-Lactamases in laboratory and clinical resistance.	D M Livermore	Clin Microbiol Rev	1995	8665470	No
3138	2248	1124.0	0.0	0.0	Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran.	R R Guillard, J H Ryther	Can J Microbiol	1962	13902807	Yes
3139	1124	1124.0	27.51	27.5	Context and behavioral processes in extinction.	Mark E Bouton	Learn Mem	2004	15466298	No
3140	1124	1124.0	24.2	24.2	Version 1.2 of the Crystallography and NMR system.	Axel T Brunger	Nat Protoc	2007	18007608	Yes
3141	2247	1123.5	50.44	25.2	Esophageal cancer.	Peter C Enzinger, Robert J Mayer	N Engl J Med	2003	14657432	No
3142	1123	1123.0	35.59	35.6	Relations between the statistics of natural images and the response properties of cortical cells.	D J Field	J Opt Soc Am A	1987	3430225	Yes
3143	1123	1123.0	0.0	0.0	Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units.	C M Venkatachalam	Biopolymers	1968	5685102	Yes
3144	1123	1123.0	21.13	21.1	Regulation of phosphoinositide-specific phospholipase C.	S G Rhee	Annu Rev Biochem	2001	11395409	No
3145	1123	1123.0	0.0	0.0	Fertilizing capacity of spermatozoa deposited into the fallopian tubes.	M C Chang	Nature	1951	14882325	Yes
3146	1123	1123.0	23.27	23.3	Up on the tightrope: natural killer cell activation and inhibition.	Lewis L Lanier	Nat Immunol	2008	18425106	No
3147	1123	1123.0	23.38	23.4	Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution.	Sean B Carroll	Cell	2008	18614008	Yes
3148	1123	1123.0	33.28	33.3	Atomic layer deposition: an overview.	Steven M George	Chem Rev	2010	19947596	Yes
3149	2245	1122.5	65.85	32.9	Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report.	P Brugada, J Brugada	J Am Coll Cardiol	1992	1309182	Yes
3150	2245	1122.5	46.43	23.2	Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133.	G A Gonzalez, M R Montminy	Cell	1989	2573431	Yes
3151	1122	1122.0	23.72	23.7	Mutator phenotype may be required for multistage carcinogenesis.	L A Loeb	Cancer Res	1991	2039987	No
3152	1122	1122.0	39.93	39.9	Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes.	M A Lemp	CLAO J	1995	8565190	No
3153	1122	1122.0	0.0	0.0	A production of amino acids under possible primitive earth conditions.	S L Miller	Science	1953	13056598	Yes
3154	1122	1122.0	22.31	22.3	Inferences, questions and possibilities in Toll-like receptor signalling.	Bruce Beutler	Nature	2004	15241424	No
3155	1122	1122.0	43.22	43.2	The evolving concept of health literacy.	Don Nutbeam	Soc Sci Med	2008	18952344	Yes
3156	1122	1122.0	34.19	34.2	BEDTools: The Swiss-Army Tool for Genome Feature Analysis.	Aaron R Quinlan	Curr Protoc Bioinformatics	2014	25199790	Yes
3157	1121	1121.0	22.41	22.4	Telomeres and human disease: ageing, cancer and beyond.	Maria A Blasco	Nat Rev Genet	2005	16136653	No
3158	1121	1121.0	37.79	37.8	Photoplethysmography and its application in clinical physiological measurement.	John Allen	Physiol Meas	2007	17322588	No
3159	2242	1121.0	66.35	33.2	Heterogeneous photocatalyst materials for water splitting.	Akihiko Kudo, Yugo Miseki	Chem Soc Rev	2009	19088977	Yes
3160	1120	1120.0	37.98	38.0	Selective attention and the organization of visual information.	J Duncan	J Exp Psychol Gen	1984	6240521	Yes
3161	1120	1120.0	32.96	33.0	Cell surface interactions with extracellular materials.	K M Yamada	Annu Rev Biochem	1983	6351729	No
3162	1120	1120.0	25.11	25.1	Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes.	M Kozak	Nucleic Acids Res	1981	7301588	Yes
3163	4480	1120.0	103.85	26.0	SCOP: a structural classification of proteins database for the investigation of sequences and structures.	A G Murzin, S E Brenner, T Hubbard, C Chothia	J Mol Biol	1995	7723011	Yes
3164	1120	1120.0	23.52	23.5	ALSCRIPT: a tool to format multiple sequence alignments.	G J Barton	Protein Eng	1993	8433969	Yes
3165	1120	1120.0	30.77	30.8	Venous thrombosis: a multicausal disease.	F R Rosendaal	Lancet	1999	10209995	No
3166	1120	1120.0	21.01	21.0	Biological robustness.	Hiroaki Kitano	Nat Rev Genet	2004	15520792	No
3167	1119	1119.0	21.53	21.5	The power and the promise of DNA methylation markers.	Peter W Laird	Nat Rev Cancer	2003	12671664	No
3168	1119	1119.0	0.0	0.0	A New Serum Type System In Man--The Lp System.	K Berg	Acta Pathol Microbiol Scand	1963	14064818	Yes
3169	4475	1118.8	144.75	36.2	Validation of a combined comorbidity index.	M Charlson, T P Szatrowski, J Peterson, J Gold	J Clin Epidemiol	1994	7722560	Yes
3170	4474	1118.5	278.09	69.5	fastp: an ultra-fast all-in-one FASTQ preprocessor.	Shifu Chen, Yanqing Zhou, Yaru Chen, Jia Gu	Bioinformatics	2018	30423086	Yes
3171	1118	1118.0	0.0	0.0	Cytoprotection by prostaglandins.	A Robert	Gastroenterology	1979	38173	Yes
3172	1118	1118.0	19.5	19.5	Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism.	M S Wold	Annu Rev Biochem	1997	9242902	No
3173	1118	1118.0	23.75	23.8	Microsatellites: simple sequences with complex evolution.	Hans Ellegren	Nat Rev Genet	2004	15153996	No
3174	1117	1117.0	34.7	34.7	MOPAC: a semiempirical molecular orbital program.	J J Stewart	J Comput Aided Mol Des	1990	2197373	No
3175	1117	1117.0	35.08	35.1	Peritonectomy procedures.	P H Sugarbaker	Ann Surg	1995	7826158	Yes
3176	1117	1117.0	20.28	20.3	The development of neural stem cells.	S Temple	Nature	2001	11689956	No
3177	1117	1117.0	21.98	22.0	VEGF and the quest for tumour angiogenesis factors.	Napoleone Ferrara	Nat Rev Cancer	2002	12360282	No
3178	1117	1117.0	26.46	26.5	Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms.	William C Aird	Circ Res	2007	17272818	No
3179	1117	1117.0	37.6	37.6	Nanobodies: natural single-domain antibodies.	Serge Muyldermans	Annu Rev Biochem	2013	23495938	No
3180	1117	1117.0	59.57	59.6	The new statistics: why and how.	Geoff Cumming	Psychol Sci	2014	24220629	Yes
3181	2233	1116.5	43.08	21.5	Rho GTPases: biochemistry and biology.	Aron B Jaffe, Alan Hall	Annu Rev Cell Dev Biol	2005	16212495	No
3182	3349	1116.3	72.38	24.1	A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.	M Serrano, G J Hannon, D Beach	Nature	1993	8259215	Yes
3183	2232	1116.0	0.0	0.0	Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms.	R J Britten, D E Kohne	Science	1968	4874239	Yes
3184	2232	1116.0	49.13	24.6	Prediction of protein secondary structure at better than 70% accuracy.	B Rost, C Sander	J Mol Biol	1993	8345525	Yes
3185	1116	1116.0	29.8	29.8	Epidemiology of women and depression.	Ronald C Kessler	J Affect Disord	2003	12646294	Yes
3186	1116	1116.0	25.51	25.5	Next-generation DNA sequencing methods.	Elaine R Mardis	Annu Rev Genomics Hum Genet	2008	18576944	No
3187	2231	1115.5	49.69	24.8	Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set.	N Sreerama, R W Woody	Anal Biochem	2000	11112271	Yes
3188	1115	1115.0	49.17	49.2	Coping theory and research: past, present, and future.	R S Lazarus	Psychosom Med	1993	8346332	No
3189	2230	1115.0	46.3	23.1	Plant pathogens and integrated defence responses to infection.	J L Dangl, J D Jones	Nature	2001	11459065	No
3190	1115	1115.0	25.43	25.4	Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach.	Michael J Sanderson	Mol Biol Evol	2002	11752195	Yes
3191	5575	1115.0	106.1	21.2	The protein kinase complement of the human genome.	G Manning, D B Whyte, R Martinez, T Hunter, S Sudarsanam	Science	2002	12471243	No
3192	1115	1115.0	40.62	40.6	PaDEL-descriptor: an open source software to calculate molecular descriptors and fingerprints.	Chun Wei Yap	J Comput Chem	2011	21425294	Yes
3193	2229	1114.5	303.19	151.6	The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak.	Hussin A Rothan, Siddappa N Byrareddy	J Autoimmun	2020	32113704	No
3194	1114	1114.0	34.68	34.7	Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate.	J E Oesterling	J Urol	1991	1707989	No
3195	1114	1114.0	42.25	42.2	Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error.	J T Daugirdas	J Am Soc Nephrol	1993	8305648	Yes
3196	1114	1114.0	23.06	23.1	Differentiation and proliferation of hematopoietic stem cells.	M Ogawa	Blood	1993	8499622	No
3197	1114	1114.0	51.76	51.8	Rhythms for Cognition: Communication through Coherence.	Pascal Fries	Neuron	2015	26447583	No
3198	1113	1113.0	0.0	0.0	Studies on histones. 7. Preparative methods for histone fractions from calf thymus.	E W Johns	Biochem J	1964	5840387	Yes
3199	1113	1113.0	0.0	0.0	The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease.	J Vague	Am J Clin Nutr	1956	13282851	Yes
3200	1113	1113.0	0.0	0.0	Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins.	R D Owen	Science	1945	17755278	Yes
3201	2225	1112.5	0.0	0.0	Microdroplet Assay Of Human Serum Cytotoxins.	P I Terasaki, J D Mcclelland	Nature	1964	14248725	Yes
3202	2224	1112.0	107.11	53.6	Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique.	S F Dworkin, L LeResche	J Craniomandib Disord	1992	1298767	No
3203	1112	1112.0	28.65	28.6	Linkage strategies for genetically complex traits. I. Multilocus models.	N Risch	Am J Hum Genet	1990	2301392	Yes
3204	2224	1112.0	73.09	36.5	The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample.	Julie D Henry, John R Crawford	Br J Clin Psychol	2005	16004657	Yes
3205	2223	1111.5	0.0	0.0	Construction of phylogenetic trees.	W M Fitch, E Margoliash	Science	1967	5334057	No
3206	2223	1111.5	70.31	35.2	Excitatory amino acid transmitters.	J C Watkins, R H Evans	Annu Rev Pharmacol Toxicol	1981	6112965	No
3207	2223	1111.5	58.98	29.5	Oxidative stress, caloric restriction, and aging.	R S Sohal, R Weindruch	Science	1996	8658196	No
3208	2223	1111.5	52.09	26.0	Regulation of wound healing by growth factors and cytokines.	Sabine Werner, Richard Grose	Physiol Rev	2003	12843410	No
3209	2223	1111.5	49.64	24.8	Blinded by the Light: The Growing Complexity of p53.	Karen H Vousden, Carol Prives	Cell	2009	19410540	No
3210	1111	1111.0	37.74	37.7	Chemoprevention of cancer.	L W Wattenberg	Cancer Res	1985	3880665	No
3211	1111	1111.0	0.0	0.0	Sex-hormone-binding globulin.	D C Anderson	Clin Endocrinol (Oxf)	1974	4134992	No
3212	1111	1111.0	23.91	23.9	Fluorescence spectroscopy of single biomolecules.	S Weiss	Science	1999	10073925	No
3213	1111	1111.0	0.0	0.0	A cytoarchitectonic atlas of the spinal cord in the cat.	B Rexed	J Comp Neurol	1954	13163236	Yes
3214	3331	1110.3	114.19	38.1	The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting.	C Kirschbaum, K M Pirke, D H Hellhammer	Neuropsychobiology	1993	8255414	Yes
3215	1110	1110.0	21.95	21.9	Cytokine receptor signalling.	J N Ihle	Nature	1995	7566171	No
3216	1110	1110.0	21.8	21.8	Regulation of cadherin-mediated adhesion in morphogenesis.	Barry M Gumbiner	Nat Rev Mol Cell Biol	2005	16025097	No
3217	1110	1110.0	27.86	27.9	Targeting DNA topoisomerase II in cancer chemotherapy.	John L Nitiss	Nat Rev Cancer	2009	19377506	No
3218	1110	1110.0	47.04	47.0	The variable nature of cognitive control: a dual mechanisms framework.	Todd S Braver	Trends Cogn Sci	2012	22245618	Yes
3219	2219	1109.5	73.52	36.8	Efficacy of the Theory of Planned Behaviour: a meta-analytic review.	C J Armitage, M Conner	Br J Soc Psychol	2001	11795063	Yes
3220	2219	1109.5	0.0	0.0	Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody.	A H Coons, M H Kaplan	J Exp Med	1950	15395569	Yes
3221	3328	1109.3	0.0	0.0	Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.	M Hamberg, J Svensson, B Samuelsson	Proc Natl Acad Sci U S A	1975	1059088	Yes
3222	3328	1109.3	85.01	28.3	Use and abuse of HOMA modeling.	Tara M Wallace, Jonathan C Levy, David R Matthews	Diabetes Care	2004	15161807	No
3223	1109	1109.0	47.33	47.3	A spreading-activation theory of retrieval in sentence production.	G S Dell	Psychol Rev	1986	3749399	Yes
3224	1109	1109.0	32.41	32.4	Cholesterol and the cell membrane.	P L Yeagle	Biochim Biophys Acta	1985	3904832	No
3225	1109	1109.0	30.94	30.9	The stress response to trauma and surgery.	J P Desborough	Br J Anaesth	2000	10927999	No
3226	1109	1109.0	30.24	30.2	Disseminating innovations in health care.	Donald M Berwick	JAMA	2003	12697800	Yes
3227	1109	1109.0	0.0	0.0	Inherited Antithrombin Deficiency Causing Thrombophilia.	O Egeberg	Thromb Diath Haemorrh	1965	14347873	Yes
3228	4434	1108.5	117.77	29.4	Prevalence and trends in obesity among US adults, 1999-2000.	Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L Johnson	JAMA	2002	12365955	Yes
3229	1108	1108.0	32.57	32.6	Animal mitochondrial DNA: structure and evolution.	D R Wolstenholme	Int Rev Cytol	1992	1452431	No
3230	1108	1108.0	19.9	19.9	Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation.	Eric C Lai	Nat Genet	2002	11896390	Yes
3231	1108	1108.0	45.19	45.2	A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading.	Cathy J Price	Neuroimage	2012	22584224	No
3232	2215	1107.5	57.77	28.9	Protein oxidation in aging, disease, and oxidative stress.	B S Berlett, E R Stadtman	J Biol Chem	1997	9252331	No
3233	1107	1107.0	35.98	36.0	Agents that increase the permeability of the outer membrane.	M Vaara	Microbiol Rev	1992	1406489	No
3234	1107	1107.0	21.71	21.7	Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.	A S Baldwin	J Clin Invest	2001	11160144	No
3235	1107	1107.0	27.31	27.3	Mode of action of membrane active antimicrobial peptides.	Yechiel Shai	Biopolymers	2002	12491537	No
3236	2214	1107.0	61.68	30.8	A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions.	Yan Zhao, Donald G Truhlar	J Chem Phys	2006	17129083	Yes
3237	1106	1106.0	34.31	34.3	Protein damage and degradation by oxygen radicals. I. general aspects.	K J Davies	J Biol Chem	1987	3036875	Yes
3238	2211	1105.5	74.76	37.4	Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation.	A E Czeizel, I Dudás	N Engl J Med	1992	1307234	Yes
3239	1105	1105.0	22.38	22.4	Primary response genes induced by growth factors and tumor promoters.	H R Herschman	Annu Rev Biochem	1991	1883198	No
3240	1104	1104.0	57.93	57.9	A "rationalized" arcsine transform.	G A Studebaker	J Speech Hear Res	1985	4046587	Yes
3241	1104	1104.0	0.0	0.0	The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion.	S Roseman	Chem Phys Lipids	1970	5476326	Yes
3242	1104	1104.0	24.61	24.6	The molecular biology of leukocyte chemoattractant receptors.	P M Murphy	Annu Rev Immunol	1994	8011292	No
3243	1104	1104.0	30.55	30.6	Production and scavenging of reactive oxygen species in chloroplasts and their functions.	Kozi Asada	Plant Physiol	2006	16760493	Yes
3244	1104	1104.0	0.0	0.0	Knee joint changes after meniscectomy.	T J Fairbank	J Bone Joint Surg Br	1948	18894618	Yes
3245	4415	1103.8	144.73	36.2	The cholinergic hypothesis of geriatric memory dysfunction.	R T Bartus, R L Dean, B Beer, A S Lippa	Science	1982	7046051	No
3246	5518	1103.6	139.3	27.9	Jalview Version 2--a multiple sequence alignment editor and analysis workbench.	Andrew M Waterhouse, James B Procter, David M A Martin, Michèle Clamp, Geoffrey J Barton	Bioinformatics	2009	19151095	Yes
3247	2207	1103.5	54.66	27.3	The protective effects of estrogen on the cardiovascular system.	M E Mendelsohn, R H Karas	N Engl J Med	1999	10362825	No
3248	1103	1103.0	39.2	39.2	Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases.	J N Wasserheit	Sex Transm Dis	1992	1595015	No
3249	2206	1103.0	44.48	22.2	RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression.	M B Shapiro, P Senapathy	Nucleic Acids Res	1987	3658675	Yes
3250	2206	1103.0	66.23	33.1	Health effects of fine particulate air pollution: lines that connect.	C Arden Pope, Douglas W Dockery	J Air Waste Manag Assoc	2006	16805397	No
3251	2206	1103.0	82.9	41.5	Nitric oxide synthases: regulation and function.	Ulrich Förstermann, William C Sessa	Eur Heart J	2012	21890489	No
3252	4411	1102.8	126.83	31.7	Biological identifications through DNA barcodes.	Paul D N Hebert, Alina Cywinska, Shelley L Ball, Jeremy R deWaard	Proc Biol Sci	2003	12614582	Yes
3253	1102	1102.0	28.04	28.0	Two-stage model of memory trace formation: a role for "noisy" brain states.	G Buzsáki	Neuroscience	1989	2687720	No
3254	12122	1102.0	316.38	28.8	Frailty in older adults: evidence for a phenotype.	L P Fried, C M Tangen, J Walston, A B Newman, C Hirsch, J Gottdiener, T Seeman, R Tracy, W J Kop, G Burke, M A McBurnie	J Gerontol A Biol Sci Med Sci	2001	11253156	Yes
3255	1102	1102.0	23.73	23.7	Molecular imaging of cancer with positron emission tomography.	Sanjiv Sam Gambhir	Nat Rev Cancer	2002	12209157	No
3256	1102	1102.0	30.86	30.9	Stronger Brønsted acids.	Takahiko Akiyama	Chem Rev	2007	17983247	Yes
3257	6612	1102.0	202.69	33.8	The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.	Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gøtzsche, Jan P Vandenbroucke	Lancet	2007	18064739	Yes
3258	3304	1101.3	102.64	34.2	SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building.	Manolo Gouy, Stéphane Guindon, Olivier Gascuel	Mol Biol Evol	2010	19854763	Yes
3259	1101	1101.0	26.22	26.2	Aptamers: an emerging class of molecules that rival antibodies in diagnostics.	S D Jayasena	Clin Chem	1999	10471678	No
3260	4404	1101.0	107.61	26.9	C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women.	P M Ridker, C H Hennekens, J E Buring, N Rifai	N Engl J Med	2000	10733371	Yes
3261	2201	1100.5	83.1	41.5	Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour.	John F Cryan, Timothy G Dinan	Nat Rev Neurosci	2012	22968153	No
3262	1100	1100.0	23.17	23.2	A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.	J Milbrandt	Science	1987	3672127	Yes
3263	1100	1100.0	26.32	26.3	Molecular drive: a cohesive mode of species evolution.	G Dover	Nature	1982	7110332	Yes
3264	1100	1100.0	34.67	34.7	Evaluating the quality of medical care. 1966.	Avedis Donabedian	Milbank Q	2005	16279964	No
3265	2200	1100.0	67.51	33.8	Chronic hepatitis B: update 2009.	Anna S F Lok, Brian J McMahon	Hepatology	2009	19714720	Yes
3266	9900	1100.0	266.35	29.6	MolProbity: all-atom structure validation for macromolecular crystallography.	Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C Richardson	Acta Crystallogr D Biol Crystallogr	2010	20057044	Yes
3267	2199	1099.5	46.87	23.4	Protein aggregation and neurodegenerative disease.	Christopher A Ross, Michelle A Poirier	Nat Med	2004	15272267	No
3268	2199	1099.5	76.15	38.1	Molecular and cellular insights into T cell exhaustion.	E John Wherry, Makoto Kurachi	Nat Rev Immunol	2015	26205583	No
3269	9895	1099.4	263.75	29.3	Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation.	Cole Trapnell, Brian A Williams, Geo Pertea, Ali Mortazavi, Gordon Kwan, Marijke J van Baren, Steven L Salzberg, Barbara J Wold, Lior Pachter	Nat Biotechnol	2010	20436464	Yes
3270	1099	1099.0	0.0	0.0	The epidemiologic transition. A theory of the epidemiology of population change.	A R Omran	Milbank Mem Fund Q	1971	5155251	Yes
3271	1099	1099.0	0.0	0.0	Mechanisms of lipid peroxide formation in animal tissues.	E D Wills	Biochem J	1966	5964963	Yes
3272	2197	1098.5	59.01	29.5	Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.	R A Ignotz, J Massagué	J Biol Chem	1986	3456347	Yes
3273	1098	1098.0	43.21	43.2	Minority stress and mental health in gay men.	I H Meyer	J Health Soc Behav	1995	7738327	Yes
3274	1098	1098.0	26.26	26.3	Cells in stress: transcriptional activation of heat shock genes.	R I Morimoto	Science	1993	8451637	No
3275	1098	1098.0	30.56	30.6	A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors.	Ron Hardman	Environ Health Perspect	2006	16451849	No
3276	1097	1097.0	20.65	20.6	The ubiquitin-proteasome pathway: on protein death and cell life.	A Ciechanover	EMBO J	1998	9857172	No
3277	1097	1097.0	23.7	23.7	Complement. Second of two parts.	M J Walport	N Engl J Med	2001	11297706	No
3278	1097	1097.0	29.76	29.8	Core affect and the psychological construction of emotion.	James A Russell	Psychol Rev	2003	12529060	No
3279	2194	1097.0	93.98	47.0	Systematic review of the health benefits of physical activity and fitness in school-aged children and youth.	Ian Janssen, Allana G Leblanc	Int J Behav Nutr Phys Act	2010	20459784	Yes
3280	5481	1096.2	110.2	22.0	Electrostatics of nanosystems: application to microtubules and the ribosome.	N A Baker, D Sept, S Joseph, M J Holst, J A McCammon	Proc Natl Acad Sci U S A	2001	11517324	Yes
3281	1096	1096.0	32.44	32.4	Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing.	M J Gasson	J Bacteriol	1983	6403500	Yes
3282	2192	1096.0	66.46	33.2	Multiple significance tests: the Bonferroni method.	J M Bland, D G Altman	BMJ	1995	7833759	Yes
3283	2192	1096.0	44.99	22.5	A survey of telomerase activity in human cancer.	J W Shay, S Bacchetti	Eur J Cancer	1997	9282118	No
3284	1096	1096.0	23.6	23.6	Epstein-Barr virus infection.	J I Cohen	N Engl J Med	2000	10944566	No
3285	4383	1095.8	0.0	0.0	The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.	P J Randle, P B Garland, C N Hales, E A Newsholme	Lancet	1963	13990765	Yes
3286	2191	1095.5	43.83	21.9	Tumour-cell invasion and migration: diversity and escape mechanisms.	Peter Friedl, Katarina Wolf	Nat Rev Cancer	2003	12724734	No
3287	1095	1095.0	20.78	20.8	Luciferase reporter gene vectors for analysis of promoters and enhancers.	S K Nordeen	Biotechniques	1988	2908509	Yes
3288	1095	1095.0	42.07	42.1	The role of endothelium in the responses of vascular smooth muscle to drugs.	R F Furchgott	Annu Rev Pharmacol Toxicol	1984	6203480	No
3289	1095	1095.0	29.95	29.9	Aging, energy, and oxidative stress in neurodegenerative diseases.	M F Beal	Ann Neurol	1995	7668820	No
3290	1095	1095.0	0.0	0.0	Cleavage of the haem-protein link by acid methylethylketone.	F W Teale	Biochim Biophys Acta	1959	13837237	Yes
3291	2190	1095.0	60.39	30.2	BODIPY dyes and their derivatives: syntheses and spectroscopic properties.	Aurore Loudet, Kevin Burgess	Chem Rev	2007	17924696	Yes
3292	1095	1095.0	33.64	33.6	Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE.	Louis B Rice	J Infect Dis	2008	18419525	No
3293	4379	1094.8	142.13	35.5	Epidemiology and causes of preterm birth.	Robert L Goldenberg, Jennifer F Culhane, Jay D Iams, Roberto Romero	Lancet	2008	18177778	No
3294	3284	1094.7	81.46	27.2	Astrocyte-endothelial interactions at the blood-brain barrier.	N Joan Abbott, Lars Rönnbäck, Elisabeth Hansson	Nat Rev Neurosci	2006	16371949	No
3295	2189	1094.5	74.14	37.1	CTFFIND4: Fast and accurate defocus estimation from electron micrographs.	Alexis Rohou, Nikolaus Grigorieff	J Struct Biol	2015	26278980	Yes
3296	1094	1094.0	32.39	32.4	Modeling tracer kinetics in dynamic Gd-DTPA MR imaging.	P S Tofts	J Magn Reson Imaging	1997	9039598	No
3297	1094	1094.0	25.45	25.4	The impact of next-generation sequencing technology on genetics.	Elaine R Mardis	Trends Genet	2008	18262675	No
3298	2188	1094.0	51.06	25.5	Next-generation DNA sequencing.	Jay Shendure, Hanlee Ji	Nat Biotechnol	2008	18846087	Yes
3299	3281	1093.7	95.56	31.9	The Patient Health Questionnaire-2: validity of a two-item depression screener.	Kurt Kroenke, Robert L Spitzer, Janet B W Williams	Med Care	2003	14583691	Yes
3300	2187	1093.5	49.06	24.5	Cell cycle control and cancer.	L H Hartwell, M B Kastan	Science	1994	7997877	No
3301	3280	1093.3	140.47	46.8	Measurement of health status. Ascertaining the minimal clinically important difference.	R Jaeschke, J Singer, G H Guyatt	Control Clin Trials	1989	2691207	Yes
3302	7653	1093.3	201.78	28.8	Integrative genomics viewer.	James T Robinson, Helga Thorvaldsdóttir, Wendy Winckler, Mitchell Guttman, Eric S Lander, Gad Getz, Jill P Mesirov	Nat Biotechnol	2011	21221095	Yes
3303	1093	1093.0	39.93	39.9	The case for motivated reasoning.	Z Kunda	Psychol Bull	1990	2270237	No
3304	2186	1093.0	64.63	32.3	The capacity of visual working memory for features and conjunctions.	S J Luck, E K Vogel	Nature	1997	9384378	Yes
3305	1093	1093.0	32.87	32.9	Subcutaneous and visceral adipose tissue: structural and functional differences.	M Mohsen Ibrahim	Obes Rev	2010	19656312	No
3306	3279	1093.0	95.24	31.7	Regulation of cancer cell metabolism.	Rob A Cairns, Isaac S Harris, Tak W Mak	Nat Rev Cancer	2011	21258394	No
3307	1093	1093.0	49.17	49.2	The Laboratory Rat: Relating Its Age With Human's.	Pallav Sengupta	Int J Prev Med	2013	23930179	Yes
3308	2185	1092.5	45.52	22.8	p53: puzzle and paradigm.	L J Ko, C Prives	Genes Dev	1996	8654922	No
3309	2185	1092.5	41.93	21.0	The druggable genome.	Andrew L Hopkins, Colin R Groom	Nat Rev Drug Discov	2002	12209152	No
3310	2185	1092.5	71.13	35.6	The reward circuit: linking primate anatomy and human imaging.	Suzanne N Haber, Brian Knutson	Neuropsychopharmacology	2010	19812543	No
3311	1092	1092.0	30.53	30.5	Riddle of biofilm resistance.	K Lewis	Antimicrob Agents Chemother	2001	11257008	No
3312	2184	1092.0	0.0	0.0	Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques.	P Gold, S O Freedman	J Exp Med	1965	14270243	Yes
3313	1092	1092.0	0.0	0.0	The purine and pyrimidine composition of deoxypentose nucleic acids.	G R Wyatt	Biochem J	1951	14838906	Yes
3314	2184	1092.0	63.39	31.7	New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays.	Jonathan B Baell, Georgina A Holloway	J Med Chem	2010	20131845	Yes
3315	3275	1091.7	86.49	28.8	The widespread regulation of microRNA biogenesis, function and decay.	Jacek Krol, Inga Loedige, Witold Filipowicz	Nat Rev Genet	2010	20661255	No
3316	2182	1091.0	87.05	43.5	A simple method to assess exercise behavior in the community.	G Godin, R J Shephard	Can J Appl Sport Sci	1985	4053261	Yes
3317	1091	1091.0	0.0	0.0	Corticosteroids and lymphoid cells.	H N Claman	N Engl J Med	1972	5043524	Yes
3318	2182	1091.0	66.62	33.3	2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity.	A Poland, J C Knutson	Annu Rev Pharmacol Toxicol	1982	6282188	No
3319	1091	1091.0	27.29	27.3	The Trk family of neurotrophin receptors.	M Barbacid	J Neurobiol	1994	7852993	No
3320	1091	1091.0	20.36	20.4	DNA methylation in cancer: too much, but also too little.	Melanie Ehrlich	Oncogene	2002	12154403	No
3321	1091	1091.0	62.2	62.2	Biological roles of glycans.	Ajit Varki	Glycobiology	2017	27558841	No
3322	4362	1090.5	152.5	38.1	Prevalence and trends in obesity among US adults, 1999-2008.	Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R Curtin	JAMA	2010	20071471	Yes
3323	2181	1090.5	52.82	26.4	Establishing, maintaining and modifying DNA methylation patterns in plants and animals.	Julie A Law, Steven E Jacobsen	Nat Rev Genet	2010	20142834	No
3324	2181	1090.5	95.55	47.8	Unique features of long non-coding RNA biogenesis and function.	Jeffrey J Quinn, Howard Y Chang	Nat Rev Genet	2016	26666209	No
3325	2180	1090.0	0.0	0.0	T antigen is bound to a host protein in SV40-transformed cells.	D P Lane, L V Crawford	Nature	1979	218111	Yes
3326	1090	1090.0	27.78	27.8	Selectins: interpreters of cell-specific carbohydrate information during inflammation.	L A Lasky	Science	1992	1439808	No
3327	1090	1090.0	22.9	22.9	T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex.	R H Schwartz	Annu Rev Immunol	1985	2415139	No
3328	1090	1090.0	27.6	27.6	Two distinct classes of carbohydrate-recognition domains in animal lectins.	K Drickamer	J Biol Chem	1988	3290208	No
3329	1090	1090.0	0.0	0.0	Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse.	S Irwin	Psychopharmacologia	1968	5679627	Yes
3330	1090	1090.0	24.05	24.1	Serine protease mechanism and specificity.	Lizbeth Hedstrom	Chem Rev	2002	12475199	No
3331	2180	1090.0	0.0	0.0	Cortisone in ulcerative colitis; final report on a therapeutic trial.	S C Truelove, L J Witts	Br Med J	1955	13260656	Yes
3332	1090	1090.0	24.11	24.1	Simple model of spiking neurons.	E M Izhikevich	IEEE Trans Neural Netw	2003	18244602	Yes
3333	2179	1089.5	70.53	35.3	Wine, alcohol, platelets, and the French paradox for coronary heart disease.	S Renaud, M de Lorgeril	Lancet	1992	1351198	Yes
3334	2179	1089.5	62.97	31.5	The acute phase response.	H Baumann, J Gauldie	Immunol Today	1994	7512342	No
3335	1089	1089.0	0.0	0.0	Time-dependent processes in memory storage.	J L McGaugh	Science	1966	5917768	Yes
3336	1089	1089.0	24.64	24.6	Current concepts of the pathogenesis of the acute coronary syndromes.	P Libby	Circulation	2001	11457759	No
3337	1089	1089.0	24.16	24.2	Toward self-organization and complex matter.	Jean-Marie Lehn	Science	2002	11923524	Yes
3338	1089	1089.0	0.0	0.0	Asymptomatic infections of the urinary tract.	E H Kass	Trans Assoc Am Physicians	1956	13380946	Yes
3339	1089	1089.0	32.22	32.2	Rethinking schizophrenia.	Thomas R Insel	Nature	2010	21068826	No
3340	1089	1089.0	54.83	54.8	Oxidative stress: a concept in redox biology and medicine.	Helmut Sies	Redox Biol	2015	25588755	No
3341	2177	1088.5	52.64	26.3	ZINC--a free database of commercially available compounds for virtual screening.	John J Irwin, Brian K Shoichet	J Chem Inf Model	2005	15667143	Yes
3342	2177	1088.5	51.36	25.7	Modes of resistance to anti-angiogenic therapy.	Gabriele Bergers, Douglas Hanahan	Nat Rev Cancer	2008	18650835	No
3343	4353	1088.2	108.82	27.2	Functional connectivity in the resting brain: a network analysis of the default mode hypothesis.	Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod Menon	Proc Natl Acad Sci U S A	2003	12506194	Yes
3344	1088	1088.0	34.11	34.1	The oxidation hypothesis of atherosclerosis.	J L Witztum	Lancet	1994	7916078	No
3345	1088	1088.0	20.29	20.3	Chronic myeloid leukemia.	C L Sawyers	N Engl J Med	1999	10219069	No
3346	1088	1088.0	0.0	0.0	Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent.	D L Morris	Science	1948	17814729	Yes
3347	3262	1087.3	221.91	74.0	SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules.	Antoine Daina, Olivier Michielin, Vincent Zoete	Sci Rep	2017	28256516	Yes
3348	4349	1087.2	126.84	31.7	AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.	Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan	Nat Cell Biol	2011	21258367	Yes
3349	4349	1087.2	180.92	45.2	Predicting effective microRNA target sites in mammalian mRNAs.	Vikram Agarwal, George W Bell, Jin-Wu Nam, David P Bartel	Elife	2015	26267216	Yes
3350	1087	1087.0	27.57	27.6	Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol.	M J Berridge	Biochem J	1983	6309155	Yes
3351	1087	1087.0	25.11	25.1	Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis.	Tirion	Phys Rev Lett	1996	10063201	Yes
3352	1087	1087.0	0.0	0.0	Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow.	R M Berne	Am J Physiol	1963	13971060	Yes
3353	1087	1087.0	28.92	28.9	A theory of magnitude: common cortical metrics of time, space and quantity.	Vincent Walsh	Trends Cogn Sci	2003	14585444	Yes
3354	2174	1087.0	49.45	24.7	microRNA functions.	Natascha Bushati, Stephen M Cohen	Annu Rev Cell Dev Biol	2007	17506695	No
3355	1087	1087.0	0.0	0.0	Aniline hydrogen phthalate as a spraying reagent for chromatography of sugars.	S M Partridge	Nature	1949	18140444	Yes
3356	5434	1086.8	156.54	31.3	Quantitative assessment of tactile allodynia in the rat paw.	S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L Yaksh	J Neurosci Methods	1994	7990513	Yes
3357	3258	1086.0	87.54	29.2	Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.	R Schreck, P Rieber, P A Baeuerle	EMBO J	1991	2065663	Yes
3358	1086	1086.0	57.45	57.5	The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation.	G A Ilizarov	Clin Orthop Relat Res	1989	2910611	Yes
3359	1086	1086.0	0.0	0.0	A teacher rating scale for use in drug studies with children.	C K Conners	Am J Psychiatry	1969	4900822	Yes
3360	1086	1086.0	36.23	36.2	Socioeconomic disadvantage and child development.	V C McLoyd	Am Psychol	1998	9491747	No
3361	1086	1086.0	37.13	37.1	A review of psychological risk factors in back and neck pain.	S J Linton	Spine (Phila Pa 1976)	2000	10788861	No
3362	3258	1086.0	89.18	29.7	Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?	Dunyaporn Trachootham, Jerome Alexandre, Peng Huang	Nat Rev Drug Discov	2009	19478820	No
3363	2171	1085.5	48.97	24.5	Synaptic activity and the construction of cortical circuits.	L C Katz, C J Shatz	Science	1996	8895456	No
3364	1085	1085.0	18.9	18.9	Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast.	R Rothstein	Methods Enzymol	1991	2005793	Yes
3365	1085	1085.0	24.99	25.0	The columnar organization of the neocortex.	V B Mountcastle	Brain	1997	9153131	No
3366	2170	1085.0	52.23	26.1	Endometriosis.	Linda C Giudice, Lee C Kao	Lancet	2004	15541453	No
3367	2169	1084.5	0.0	0.0	Micromethod for the direct determination of serum triglycerides.	E Van Handel, D B Zilversmit	J Lab Clin Med	1957	13439279	Yes
3368	10844	1084.4	280.74	28.1	Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.	M Dominici, K Le Blanc, I Mueller, I Slaper-Cortenbach, Fc Marini, Ds Krause, Rj Deans, A Keating, Dj Prockop, Em Horwitz	Cytotherapy	2006	16923606	Yes
3369	1084	1084.0	37.38	37.4	Multiple organ failure. Pathophysiology and potential future therapy.	E A Deitch	Ann Surg	1992	1503516	No
3370	3252	1084.0	68.95	23.0	Computer visualization of three-dimensional image data using IMOD.	J R Kremer, D N Mastronarde, J R McIntosh	J Struct Biol	1996	8742726	Yes
3371	2168	1084.0	48.7	24.4	Obesity and insulin resistance.	B B Kahn, J S Flier	J Clin Invest	2000	10953022	No
3372	1084	1084.0	20.82	20.8	Focal adhesion kinase: the first ten years.	J Thomas Parsons	J Cell Sci	2003	12640026	No
3373	1084	1084.0	0.0	0.0	The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs.	M Vogt	J Physiol	1954	13152692	Yes
3374	5418	1083.6	115.31	23.1	The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.	J W Harper, G R Adami, N Wei, K Keyomarsi, S J Elledge	Cell	1993	8242751	Yes
3375	2167	1083.5	0.0	0.0	Peroxidase-labeled antibody. A new method of conjugation.	P K Nakane, A Kawaoi	J Histochem Cytochem	1974	4443551	Yes
3376	2167	1083.5	45.89	22.9	The Hsp70 and Hsp60 chaperone machines.	B Bukau, A L Horwich	Cell	1998	9476895	No
3377	2167	1083.5	0.0	0.0	A revision of the Schoenheimer-Sperry method for cholesterol determination.	W M Sperry, M Webb	J Biol Chem	1950	14794694	Yes
3378	1083	1083.0	30.9	30.9	Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens.	T Feizi	Nature	1985	2579340	Yes
3379	1083	1083.0	33.01	33.0	Inferring microstructural features and the physiological state of tissues from diffusion-weighted images.	P J Basser	NMR Biomed	1995	8739270	No
3380	1083	1083.0	26.18	26.2	Quantification of beta-sheet amyloid fibril structures with thioflavin T.	H LeVine	Methods Enzymol	1999	10507030	Yes
3381	1083	1083.0	28.71	28.7	Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity.	F P Guengerich	Chem Res Toxicol	2001	11409933	No
3382	1083	1083.0	36.48	36.5	The Danish Register of Causes of Death.	Karin Helweg-Larsen	Scand J Public Health	2011	21775346	Yes
3383	2165	1082.5	48.03	24.0	Regeneration beyond the glial scar.	Jerry Silver, Jared H Miller	Nat Rev Neurosci	2004	14735117	No
3384	3247	1082.3	90.14	30.0	Matrix metalloproteinases: regulators of the tumor microenvironment.	Kai Kessenbrock, Vicki Plaks, Zena Werb	Cell	2010	20371345	No
3385	1082	1082.0	41.92	41.9	A new international staging system for lung cancer.	C F Mountain	Chest	1986	3514171	No
3386	2164	1082.0	77.34	38.7	Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry.	A I Basbaum, H L Fields	Annu Rev Neurosci	1984	6143527	No
3387	2164	1082.0	44.87	22.4	Genomic control for association studies.	B Devlin, K Roeder	Biometrics	1999	11315092	Yes
3388	1082	1082.0	34.91	34.9	Predictors of postpartum depression: an update.	C T Beck	Nurs Res	2001	11570712	Yes
3389	1082	1082.0	103.51	103.5	SARS-CoV-2 vaccines in development.	Florian Krammer	Nature	2020	32967006	No
3390	3245	1081.7	93.71	31.2	A sensitive and reliable locomotor rating scale for open field testing in rats.	D M Basso, M S Beattie, J C Bresnahan	J Neurotrauma	1995	7783230	Yes
3391	3245	1081.7	87.96	29.3	A nonparametric method for automatic correction of intensity nonuniformity in MRI data.	J G Sled, A P Zijdenbos, A C Evans	IEEE Trans Med Imaging	1998	9617910	Yes
3392	2163	1081.5	47.2	23.6	Regulation of translation initiation in eukaryotes: mechanisms and biological targets.	Nahum Sonenberg, Alan G Hinnebusch	Cell	2009	19239892	No
3393	2163	1081.5	82.54	41.3	Severe sepsis and septic shock.	Derek C Angus, Tom van der Poll	N Engl J Med	2013	23984731	No
3394	1081	1081.0	51.29	51.3	Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder.	M Rutter	Br J Psychiatry	1985	3830321	Yes
3395	1081	1081.0	51.81	51.8	Analysis of Fickian and non-Fickian drug release from polymers.	N A Peppas	Pharm Acta Helv	1985	4011621	Yes
3396	1081	1081.0	23.41	23.4	PHD: predicting one-dimensional protein structure by profile-based neural networks.	B Rost	Methods Enzymol	1996	8743704	Yes
3397	1081	1081.0	28.01	28.0	Neuropathology of Parkinson's disease.	L S Forno	J Neuropathol Exp Neurol	1996	8786384	No
3398	2162	1081.0	49.86	24.9	A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure.	J N Cohn, G Tognoni	N Engl J Med	2001	11759645	Yes
3399	3243	1081.0	89.52	29.8	Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation.	Robert G Hart, Lesly A Pearce, Maria I Aguilar	Ann Intern Med	2007	17577005	Yes
3400	1080	1080.0	0.0	0.0	Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities.	F Fonnum	Biochem J	1969	4982085	Yes
3401	2160	1080.0	47.45	23.7	Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age.	T Hunter, J Pines	Cell	1994	7954824	No
3402	2160	1080.0	52.36	26.2	Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects.	R P Rao, D H Ballard	Nat Neurosci	1999	10195184	Yes
3403	6480	1080.0	148.61	24.8	Principal components analysis corrects for stratification in genome-wide association studies.	Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David Reich	Nat Genet	2006	16862161	Yes
3404	1080	1080.0	42.5	42.5	Microtiter dish biofilm formation assay.	George A O'Toole	J Vis Exp	2011	21307833	Yes
3405	2159	1079.5	68.7	34.4	Glutamate and the pathophysiology of hypoxic--ischemic brain damage.	S M Rothman, J W Olney	Ann Neurol	1986	2421636	No
3406	2159	1079.5	50.21	25.1	Hepatitis C virus infection.	G M Lauer, B D Walker	N Engl J Med	2001	11439948	No
3407	10794	1079.4	251.35	25.1	Scalable molecular dynamics with NAMD.	James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kalé, Klaus Schulten	J Comput Chem	2005	16222654	Yes
3408	6476	1079.3	160.8	26.8	Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients.	S Yusuf, P Sleight, J Pogue, J Bosch, R Davies, G Dagenais	N Engl J Med	2000	10639539	Yes
3409	1079	1079.0	20.58	20.6	At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells.	M Kozak	J Mol Biol	1987	3681984	Yes
3410	1079	1079.0	0.0	0.0	A kinetic photometric method for serum gamma-glutamyl transpeptidase.	G Szasz	Clin Chem	1969	5773262	Yes
3411	1078	1078.0	0.0	0.0	Cell lines derived from late embryonic stages of Drosophila melanogaster.	I Schneider	J Embryol Exp Morphol	1972	4625067	Yes
3412	1078	1078.0	30.4	30.4	AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function.	D Grahame Hardie	Genes Dev	2011	21937710	No
3413	2155	1077.5	74.88	37.4	A simple index of Crohn's-disease activity.	R F Harvey, J M Bradshaw	Lancet	1980	6102236	Yes
3414	6465	1077.5	171.53	28.6	Prediction of coronary heart disease using risk factor categories.	P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B Kannel	Circulation	1998	9603539	Yes
3415	1077	1077.0	0.0	0.0	Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice.	D L Coleman	Diabetologia	1978	350680	No
3416	2154	1077.0	58.61	29.3	Mechanisms of biofilm resistance to antimicrobial agents.	T F Mah, G A O'Toole	Trends Microbiol	2001	11166241	No
3417	1077	1077.0	32.2	32.2	The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin.	R G Pertwee	Br J Pharmacol	2008	17828291	No
3418	1077	1077.0	25.81	25.8	Solid-state nanopores.	Cees Dekker	Nat Nanotechnol	2007	18654264	No
3419	1077	1077.0	68.39	68.4	DLS and zeta potential - What they are and what they are not?	Sourav Bhattacharjee	J Control Release	2016	27297779	No
3420	1076	1076.0	0.0	0.0	Evolution of ageing.	T B Kirkwood	Nature	1977	593350	Yes
3421	2152	1076.0	45.39	22.7	Mitogen-activated protein kinase pathways.	M J Robinson, M H Cobb	Curr Opin Cell Biol	1997	9069255	No
3422	2152	1076.0	57.97	29.0	Fitness effects on the cognitive function of older adults: a meta-analytic study.	Stanley Colcombe, Arthur F Kramer	Psychol Sci	2003	12661673	Yes
3423	3227	1075.7	117.41	39.1	Neighborhoods and violent crime: a multilevel study of collective efficacy.	R J Sampson, S W Raudenbush, F Earls	Science	1997	9252316	Yes
3424	6451	1075.2	140.22	23.4	Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.	D A Melton, P A Krieg, M R Rebagliati, T Maniatis, K Zinn, M R Green	Nucleic Acids Res	1984	6091052	Yes
3425	1075	1075.0	0.0	0.0	Association of the B-cell alloantigen DRw4 with rheumatoid arthritis.	P Stastny	N Engl J Med	1978	147420	Yes
3426	1075	1075.0	0.0	0.0	Protein denaturation. C. Theoretical models for the mechanism of denaturation.	C Tanford	Adv Protein Chem	1970	4912353	No
3427	1075	1075.0	25.2	25.2	P-450 metabolites of arachidonic acid in the control of cardiovascular function.	Richard J Roman	Physiol Rev	2002	11773611	No
3428	2150	1075.0	64.52	32.3	Strategies in the design of nanoparticles for therapeutic applications.	Robby A Petros, Joseph M DeSimone	Nat Rev Drug Discov	2010	20616808	No
3429	1075	1075.0	45.23	45.2	The biogenesis and emerging roles of circular RNAs.	Ling-Ling Chen	Nat Rev Mol Cell Biol	2016	26908011	Yes
3430	2149	1074.5	50.53	25.3	Cellular uptake of the tat protein from human immunodeficiency virus.	A D Frankel, C O Pabo	Cell	1988	2849510	Yes
3431	6446	1074.3	188.29	31.4	The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis.	A Miyake, N P Friedman, M J Emerson, A H Witzki, A Howerter, T D Wager	Cogn Psychol	2000	10945922	Yes
3432	2148	1074.0	46.8	23.4	Roles of CHOP/GADD153 in endoplasmic reticulum stress.	S Oyadomari, M Mori	Cell Death Differ	2004	14685163	No
3433	2148	1074.0	59.02	29.5	The ubiquitin code.	David Komander, Michael Rape	Annu Rev Biochem	2012	22524316	No
3434	1073	1073.0	52.39	52.4	Self-discrepancy: a theory relating self and affect.	E T Higgins	Psychol Rev	1987	3615707	Yes
3435	1073	1073.0	25.08	25.1	Selectins and their ligands: current concepts and controversies.	G S Kansas	Blood	1996	8896391	No
3436	1073	1073.0	22.17	22.2	Osmotic stress signaling and osmoadaptation in yeasts.	Stefan Hohmann	Microbiol Mol Biol Rev	2002	12040128	No
3437	1073	1073.0	22.92	22.9	Membrane recognition by phospholipid-binding domains.	Mark A Lemmon	Nat Rev Mol Cell Biol	2008	18216767	No
3438	17168	1073.0	515.09	32.2	New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1).	E A Eisenhauer, P Therasse, J Bogaerts, L H Schwartz, D Sargent, R Ford, J Dancey, S Arbuck, S Gwyther, M Mooney, L Rubinstein, L Shankar, L Dodd, R Kaplan, D Lacombe, J Verweij	Eur J Cancer	2009	19097774	No
3439	2146	1073.0	66.57	33.3	Type 2 diabetes as an inflammatory disease.	Marc Y Donath, Steven E Shoelson	Nat Rev Immunol	2011	21233852	No
3440	2145	1072.5	52.54	26.3	Toxoplasmosis.	J G Montoya, O Liesenfeld	Lancet	2004	15194258	No
3441	3217	1072.3	0.0	0.0	Depression: a new animal model sensitive to antidepressant treatments.	R D Porsolt, M Le Pichon, M Jalfre	Nature	1977	559941	Yes
3442	1072	1072.0	21.39	21.4	Coiled coils: new structures and new functions.	A Lupas	Trends Biochem Sci	1996	8918191	No
3443	1072	1072.0	18.9	18.9	Regulatory T cells in autoimmmunity*.	E M Shevach	Annu Rev Immunol	2000	10837065	No
3444	2144	1072.0	47.74	23.9	Deep tissue two-photon microscopy.	Fritjof Helmchen, Winfried Denk	Nat Methods	2005	16299478	No
3445	1072	1072.0	23.0	23.0	Phenotypic plasticity and the epigenetics of human disease.	Andrew P Feinberg	Nature	2007	17522677	No
3446	1072	1072.0	33.58	33.6	A practical solution to the pervasive problems of p values.	Eric-Jan Wagenmakers	Psychon Bull Rev	2007	18087943	Yes
3447	2143	1071.5	0.0	0.0	Chronic catheterization of the spinal subarachnoid space.	T L Yaksh, T A Rudy	Physiol Behav	1976	14677603	Yes
3448	1071	1071.0	0.0	0.0	Statistical quality control and routine data processing for radioimmunoassays and immunoradiometric assays.	D Rodbard	Clin Chem	1974	4370388	No
3449	1071	1071.0	38.68	38.7	Methods for dealing with reaction time outliers.	R Ratcliff	Psychol Bull	1993	8272468	Yes
3450	1071	1071.0	0.0	0.0	The Permeability Of Capillaries In Various Organs As Determined By Use Of The 'Indicator Diffusion' Method.	C Crone	Acta Physiol Scand	1963	14078649	Yes
3451	1071	1071.0	24.31	24.3	Personal genomes: The case of the missing heritability.	Brendan Maher	Nature	2008	18987709	No
3452	1070	1070.0	24.6	24.6	Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system.	T Ikemura	J Mol Biol	1981	6175758	Yes
3453	1070	1070.0	36.15	36.1	Enhancing the quality and credibility of qualitative analysis.	M Q Patton	Health Serv Res	1999	10591279	No
3454	2140	1070.0	37.74	18.9	A synthetic oscillatory network of transcriptional regulators.	M B Elowitz, S Leibler	Nature	2000	10659856	Yes
3455	1070	1070.0	27.09	27.1	Formation and function of the myofibroblast during tissue repair.	Boris Hinz	J Invest Dermatol	2007	17299435	No
3456	1069	1069.0	30.14	30.1	Transport of molecules in the tumor interstitium: a review.	R K Jain	Cancer Res	1987	3555767	No
3457	1069	1069.0	0.0	0.0	Tests for emotionality in rats and mice: a review.	J Archer	Anim Behav	1973	4578750	No
3458	1069	1069.0	0.0	0.0	Central dogma of molecular biology.	F Crick	Nature	1970	4913914	No
3459	1069	1069.0	23.86	23.9	Molecular mechanisms of myocardial remodeling.	B Swynghedauw	Physiol Rev	1999	9922372	No
3460	1069	1069.0	20.31	20.3	Progress in human tumour immunology and immunotherapy.	S A Rosenberg	Nature	2001	11357146	No
3461	1069	1069.0	0.0	0.0	Motivation reconsidered: the concept of competence.	R W White	Psychol Rev	1959	13844397	Yes
3462	2137	1068.5	0.0	0.0	A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250.	J J Sedmak, S E Grossberg	Anal Biochem	1977	68686	Yes
3463	5342	1068.4	163.19	32.6	Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure.	Salim Yusuf, Bertram Pitt, Clarence E Davis, William B Hood, Jay N Cohn	N Engl J Med	1991	2057034	Yes
3464	1068	1068.0	0.0	0.0	Functional connections between cells as revealed by dye-coupling with a highly fluorescent naphthalimide tracer.	W W Stewart	Cell	1978	688392	Yes
3465	1068	1068.0	54.31	54.3	The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury.	J A Koufman	Laryngoscope	1991	1895864	No
3466	2136	1068.0	43.38	21.7	Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm.	P E Wright, H J Dyson	J Mol Biol	1999	10550212	No
3467	1068	1068.0	29.87	29.9	On the utility of P3 amplitude as a measure of processing capacity.	A Kok	Psychophysiology	2001	11352145	No
3468	1068	1068.0	24.14	24.1	Lithium batteries and cathode materials.	M Stanley Whittingham	Chem Rev	2004	15669156	Yes
3469	1068	1068.0	25.33	25.3	Anatomy and regulation of the central melanocortin system.	Roger D Cone	Nat Neurosci	2005	15856065	No
3470	2135	1067.5	0.0	0.0	The growth of mouse bone marrow cells in vitro.	T R Bradley, D Metcalf	Aust J Exp Biol Med Sci	1966	4164182	Yes
3471	1067	1067.0	0.0	0.0	The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture.	J Cassel	Am J Epidemiol	1976	782233	No
3472	2134	1067.0	0.0	0.0	The pathogenesis of atherosclerosis (first of two parts).	R Ross, J A Glomset	N Engl J Med	1976	819830	No
3473	2134	1067.0	0.0	0.0	Binding of soluble form of fibroblast surface protein, fibronectin, to collagen.	E Engvall, E Ruoslahti	Int J Cancer	1977	903179	Yes
3474	1067	1067.0	0.0	0.0	Microtubule formation in vitro in solutions containing low calcium concentrations.	R C Weisenberg	Science	1972	4626639	Yes
3475	1067	1067.0	22.02	22.0	mRNA stability in mammalian cells.	J Ross	Microbiol Rev	1995	7565413	No
3476	1067	1067.0	23.52	23.5	ECM and cell surface proteolysis: regulating cellular ecology.	Z Werb	Cell	1997	9390552	No
3477	1067	1067.0	23.8	23.8	New ideas about atrial fibrillation 50 years on.	Stanley Nattel	Nature	2002	11805846	No
3478	1067	1067.0	22.18	22.2	Understanding the odd science of aging.	Thomas B L Kirkwood	Cell	2005	15734677	No
3479	1067	1067.0	25.93	25.9	Transcriptional paradigms in mammalian mitochondrial biogenesis and function.	Richard C Scarpulla	Physiol Rev	2008	18391175	No
3480	3201	1067.0	195.0	65.0	Shedding light on the cell biology of extracellular vesicles.	Guillaume van Niel, Gisela D'Angelo, Graça Raposo	Nat Rev Mol Cell Biol	2018	29339798	No
3481	2133	1066.5	79.73	39.9	The Modified Mini-Mental State (3MS) examination.	E L Teng, H C Chui	J Clin Psychiatry	1987	3611032	Yes
3482	3199	1066.3	90.06	30.0	Spirometric reference values from a sample of the general U.S. population.	J L Hankinson, J R Odencrantz, K B Fedan	Am J Respir Crit Care Med	1999	9872837	Yes
3483	1066	1066.0	24.84	24.8	Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.	S H Kaufmann	Cancer Res	1989	2790800	Yes
3484	2132	1066.0	84.64	42.3	Statistical methods for assessing measurement error (reliability) in variables relevant to sports medicine.	G Atkinson, A M Nevill	Sports Med	1998	9820922	No
3485	1066	1066.0	25.58	25.6	Differential projections of the infralimbic and prelimbic cortex in the rat.	Robert P Vertes	Synapse	2004	14579424	Yes
3486	1066	1066.0	0.0	0.0	The stereotaxic method and radiosurgery of the brain.	L Leksell	Acta Chir Scand	1951	14914373	Yes
3487	10660	1066.0	402.14	40.2	The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration.	Alessandro Liberati, Douglas G Altman, Jennifer Tetzlaff, Cynthia Mulrow, Peter C Gøtzsche, John P A Ioannidis, Mike Clarke, P J Devereaux, Jos Kleijnen, David Moher	BMJ	2009	19622552	No
3488	2132	1066.0	50.2	25.1	The Polycomb complex PRC2 and its mark in life.	Raphaël Margueron, Danny Reinberg	Nature	2011	21248841	No
3489	1066	1066.0	53.18	53.2	Salience processing and insular cortical function and dysfunction.	Lucina Q Uddin	Nat Rev Neurosci	2015	25406711	No
3490	1065	1065.0	38.49	38.5	Coronary physiology.	E O Feigl	Physiol Rev	1983	6296890	No
3491	1065	1065.0	0.0	0.0	The effect of emotion on cue utilization and the organization of behavior.	J A Easterbrook	Psychol Rev	1959	13658305	Yes
3492	1065	1065.0	34.81	34.8	Social support and health: a review of physiological processes potentially underlying links to disease outcomes.	Bert N Uchino	J Behav Med	2006	16758315	No
3493	6390	1065.0	177.68	29.6	Cancer statistics, 2007.	Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Taylor Murray, Jiaquan Xu, Michael J Thun	CA Cancer J Clin	2007	17237035	Yes
3494	4260	1065.0	118.1	29.5	Organometal halide perovskites as visible-light sensitizers for photovoltaic cells.	Akihiro Kojima, Kenjiro Teshima, Yasuo Shirai, Tsutomu Miyasaka	J Am Chem Soc	2009	19366264	Yes
3495	3194	1064.7	0.0	0.0	Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells.	M Jondal, G Holm, H Wigzell	J Exp Med	1972	4114496	Yes
3496	1064	1064.0	29.84	29.8	Mitochondrial genetics: a paradigm for aging and degenerative diseases?	D C Wallace	Science	1992	1533953	Yes
3497	1064	1064.0	27.37	27.4	Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system.	J P Tam	Proc Natl Acad Sci U S A	1988	3399498	Yes
3498	1064	1064.0	0.0	0.0	A colorimetric method for estimating serum triglycerides.	M J Fletcher	Clin Chim Acta	1968	5696963	Yes
3499	1064	1064.0	18.38	18.4	Molecular mechanisms of axon guidance.	Barry J Dickson	Science	2002	12471249	No
3500	1064	1064.0	36.21	36.2	Mediators and mechanisms of change in psychotherapy research.	Alan E Kazdin	Annu Rev Clin Psychol	2007	17716046	No
3501	2127	1063.5	62.9	31.4	Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation.	J M Reul, E R de Kloet	Endocrinology	1985	2998738	Yes
3502	3190	1063.3	114.44	38.1	Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material.	P S Walsh, D A Metzger, R Higuchi	Biotechniques	1991	1867860	Yes
3503	1063	1063.0	36.58	36.6	Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases.	K Tamura	Mol Biol Evol	1992	1630306	Yes
3504	2126	1063.0	80.57	40.3	Visual search and stimulus similarity.	J Duncan, G W Humphreys	Psychol Rev	1989	2756067	Yes
3505	1063	1063.0	29.81	29.8	Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review.	John W Newcomer	CNS Drugs	2005	15998156	No
3506	1063	1063.0	99.19	99.2	User's guide to correlation coefficients.	Haldun Akoglu	Turk J Emerg Med	2018	30191186	No
3507	2125	1062.5	88.41	44.2	Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications.	L A Clark, D Watson	J Abnorm Psychol	1991	1918611	No
3508	1062	1062.0	0.0	0.0	Avidin.	N M Green	Adv Protein Chem	1975	237414	Yes
3509	1062	1062.0	21.9	21.9	The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells.	D Metcalf	Nature	1989	2469962	No
3510	1062	1062.0	30.25	30.2	Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine.	E M Tan	Adv Immunol	1982	6182766	No
3511	1062	1062.0	30.25	30.2	Limbic-cortical dysregulation: a proposed model of depression.	H S Mayberg	J Neuropsychiatry Clin Neurosci	1997	9276848	No
3512	1062	1062.0	31.86	31.9	Spatially heterogeneous dynamics in supercooled liquids.	M D Ediger	Annu Rev Phys Chem	2000	11031277	Yes
3513	1062	1062.0	24.64	24.6	The prefrontal cortex--an update: time is of the essence.	J M Fuster	Neuron	2001	11394996	No
3514	2124	1062.0	65.7	32.9	Self-management education: history, definition, outcomes, and mechanisms.	Kate R Lorig, Halsted Holman	Ann Behav Med	2003	12867348	No
3515	2123	1061.5	79.99	40.0	Understanding face recognition.	V Bruce, A Young	Br J Psychol	1986	3756376	Yes
3516	2123	1061.5	0.0	0.0	Histochemistry of hepatic phosphatases of a physiologic pH; with special reference to the demonstration of bile canaliculi.	M Wachstein, E Meisel	Am J Clin Pathol	1957	13410831	Yes
3517	2123	1061.5	53.69	26.8	Adipocytokines: mediators linking adipose tissue, inflammation and immunity.	Herbert Tilg, Alexander R Moschen	Nat Rev Immunol	2006	16998510	No
3518	3184	1061.3	106.16	35.4	Development and applications of CRISPR-Cas9 for genome engineering.	Patrick D Hsu, Eric S Lander, Feng Zhang	Cell	2014	24906146	No
3519	1061	1061.0	30.71	30.7	Muscarinic receptors--characterization, coupling and function.	M P Caulfield	Pharmacol Ther	1993	7504306	No
3520	2122	1061.0	0.0	0.0	A Generalization Of The Retention Index System Including Linear Temperature Programmed Gas-Liquid Partition Chromatography.	H Vandendool, P D Kratz	J Chromatogr	1963	14062605	Yes
3521	1061	1061.0	19.45	19.4	NFAT proteins: key regulators of T-cell development and function.	Fernando Macian	Nat Rev Immunol	2005	15928679	No
3522	4243	1060.8	216.8	54.2	National Institute of Mental Health Diagnostic Interview Schedule. Its history, characteristics, and validity.	L N Robins, J E Helzer, J Croughan, K S Ratcliff	Arch Gen Psychiatry	1981	6260053	Yes
3523	2121	1060.5	0.0	0.0	Calcium-dependent bacteriophage DNA infection.	M Mandel, A Higa	J Mol Biol	1970	4922220	Yes
3524	1060	1060.0	25.86	25.9	The granulocyte-macrophage colony-stimulating factors.	D Metcalf	Science	1985	2990035	No
3525	1060	1060.0	53.04	53.0	Osseointegration and its experimental background.	P I Brånemark	J Prosthet Dent	1983	6352924	No
3526	1060	1060.0	29.84	29.8	Determination of total protein.	G L Peterson	Methods Enzymol	1983	6855607	Yes
3527	4240	1060.0	156.3	39.1	Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials.	K F Schulz, I Chalmers, R J Hayes, D G Altman	JAMA	1995	7823387	Yes
3528	1060	1060.0	29.53	29.5	Levels of racism: a theoretic framework and a gardener's tale.	C P Jones	Am J Public Health	2000	10936998	Yes
3529	1060	1060.0	25.43	25.4	Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures.	Frank Würthner	Chem Commun (Camb)	2004	15263926	Yes
3530	1060	1060.0	26.89	26.9	Pathogenesis of osteoporosis: concepts, conflicts, and prospects.	Lawrence G Raisz	J Clin Invest	2005	16322775	No
3531	2120	1060.0	73.05	36.5	Long non-coding RNAs: new players in cell differentiation and development.	Alessandro Fatica, Irene Bozzoni	Nat Rev Genet	2014	24296535	No
3532	2119	1059.5	55.2	27.6	Verification of protein structures: patterns of nonbonded atomic interactions.	C Colovos, T O Yeates	Protein Sci	1993	8401235	Yes
3533	1059	1059.0	27.02	27.0	Axonal growth-associated proteins.	J H Skene	Annu Rev Neurosci	1989	2648946	No
3534	2118	1059.0	42.47	21.2	A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli.	C S Hoffman, F Winston	Gene	1987	3319781	Yes
3535	1059	1059.0	0.0	0.0	The ultrastructural basis of capillary permeability studied with peroxidase as a tracer.	M J Karnovsky	J Cell Biol	1967	6061717	Yes
3536	1059	1059.0	30.52	30.5	Pathogenetic mechanisms of septic shock.	J E Parrillo	N Engl J Med	1993	8479467	No
3537	4236	1059.0	109.91	27.5	Real time quantitative PCR.	C A Heid, J Stevens, K J Livak, P M Williams	Genome Res	1996	8908518	Yes
3538	1059	1059.0	22.22	22.2	Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution.	Z Yang	Mol Biol Evol	1998	9580986	Yes
3539	2117	1058.5	0.0	0.0	Use of glucose oxidase, peroxidase, and O-dianisidine in determination of blood and urinary glucose.	A S Huggett, D A Nixon	Lancet	1957	13464070	Yes
3540	1058	1058.0	30.17	30.2	Junctional intercellular communication: the cell-to-cell membrane channel.	W R Loewenstein	Physiol Rev	1981	6270711	No
3541	1058	1058.0	19.4	19.4	Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.	R A Frye	Biochem Biophys Res Commun	2000	10873683	Yes
3542	1058	1058.0	22.8	22.8	The advantages and disadvantages of being polyploid.	Luca Comai	Nat Rev Genet	2005	16304599	No
3543	1058	1058.0	0.0	0.0	The Stability of Broken Ends of Chromosomes in Zea Mays.	B McClintock	Genetics	1941	17247004	Yes
3544	1058	1058.0	21.8	21.8	Models, mechanisms and clinical evidence for cancer dormancy.	Julio A Aguirre-Ghiso	Nat Rev Cancer	2007	17957189	No
3545	2116	1058.0	48.56	24.3	Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.	William G Kaelin, Peter J Ratcliffe	Mol Cell	2008	18498744	No
3546	1057	1057.0	38.4	38.4	Spin trapping: ESR parameters of spin adducts.	G R Buettner	Free Radic Biol Med	1987	2826304	No
3547	1057	1057.0	31.82	31.8	Cognitive and affective development in adolescence.	Laurence Steinberg	Trends Cogn Sci	2005	15668099	No
3548	1057	1057.0	21.01	21.0	mTOR and cancer: insights into a complex relationship.	David M Sabatini	Nat Rev Cancer	2006	16915295	No
3549	1057	1057.0	0.0	0.0	A Serological Differentiation Of Human And Other Groups Of Hemolytic Streptococci.	R C Lancefield	J Exp Med	1933	19870148	Yes
3550	2114	1057.0	98.99	49.5	Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.	Roel Nusse, Hans Clevers	Cell	2017	28575679	No
3551	2113	1056.5	66.76	33.4	Reactive oxygen species, cellular redox systems, and apoptosis.	Magdalena L Circu, Tak Yee Aw	Free Radic Biol Med	2010	20045723	No
3552	2112	1056.0	62.85	31.4	The biochemistry of P-glycoprotein-mediated multidrug resistance.	J A Endicott, V Ling	Annu Rev Biochem	1989	2570548	No
3553	2112	1056.0	95.5	47.8	Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics.	J B Mulliken, J Glowacki	Plast Reconstr Surg	1982	7063565	Yes
3554	1056	1056.0	39.07	39.1	Relativistic electronic-structure calculations employing a two-component no-pair formalism with external-field projection operators.	Hess	Phys Rev A Gen Phys	1986	9897114	Yes
3555	1055	1055.0	28.67	28.7	T-cell growth factor.	K A Smith	Immunol Rev	1980	7000676	No
3556	2110	1055.0	37.37	18.7	Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain.	W Gu, R G Roeder	Cell	1997	9288740	Yes
3557	1055	1055.0	30.72	30.7	Neurophysiological and computational principles of cortical rhythms in cognition.	Xiao-Jing Wang	Physiol Rev	2010	20664082	No
3558	1054	1054.0	39.55	39.5	Infection by verocytotoxin-producing Escherichia coli.	M A Karmali	Clin Microbiol Rev	1989	2644022	No
3559	2108	1054.0	53.87	26.9	Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis.	M S Brown, J L Goldstein	Annu Rev Biochem	1983	6311077	No
3560	1054	1054.0	35.45	35.5	Why we need observational studies to evaluate the effectiveness of health care.	N Black	BMJ	1996	8634569	Yes
3561	1054	1054.0	26.12	26.1	Anti-inflammatory actions of glucocorticoids: molecular mechanisms.	P J Barnes	Clin Sci (Lond)	1998	9854452	No
3562	1054	1054.0	30.62	30.6	The role of rumination in depressive disorders and mixed anxiety/depressive symptoms.	S Nolen-Hoeksema	J Abnorm Psychol	2000	11016119	Yes
3563	1054	1054.0	0.0	0.0	The perceptron: a probabilistic model for information storage and organization in the brain.	F Rosenblatt	Psychol Rev	1958	13602029	Yes
3564	1054	1054.0	25.27	25.3	Nitric oxide, oxidants, and protein tyrosine nitration.	Rafael Radi	Proc Natl Acad Sci U S A	2004	15020765	Yes
3565	1054	1054.0	47.49	47.5	Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation.	Karimollah Hajian-Tilaki	Caspian J Intern Med	2013	24009950	No
3566	2106	1053.0	43.3	21.6	In search of the 'missing self': MHC molecules and NK cell recognition.	H G Ljunggren, K Kärre	Immunol Today	1990	2201309	No
3567	1053	1053.0	0.0	0.0	Epidemiology of cancer of the colon and rectum.	D P Burkitt	Cancer	1971	5165022	Yes
3568	2106	1053.0	47.85	23.9	Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis.	Daniel J Hicklin, Lee M Ellis	J Clin Oncol	2005	15585754	No
3569	2106	1053.0	75.21	37.6	Factors affecting wound healing.	S Guo, L A Dipietro	J Dent Res	2010	20139336	No
3570	1053	1053.0	51.14	51.1	Machine Learning in Medicine.	Rahul C Deo	Circulation	2015	26572668	No
3571	1052	1052.0	26.01	26.0	DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability.	J F Ward	Prog Nucleic Acid Res Mol Biol	1988	3065826	No
3572	2104	1052.0	40.22	20.1	Wnt signaling: a common theme in animal development.	K M Cadigan, R Nusse	Genes Dev	1997	9407023	No
3573	1052	1052.0	27.32	27.3	Glutathione and its role in cellular functions.	H Sies	Free Radic Biol Med	1999	10569624	No
3574	1052	1052.0	22.17	22.2	Oxidant signals and oxidative stress.	Toren Finkel	Curr Opin Cell Biol	2003	12648682	No
3575	1052	1052.0	23.22	23.2	Pedigree disequilibrium tests for multilocus haplotypes.	Frank Dudbridge	Genet Epidemiol	2003	12916020	Yes
3576	1052	1052.0	51.75	51.8	Inflammation, metaflammation and immunometabolic disorders.	Gökhan S Hotamisligil	Nature	2017	28179656	No
3577	6311	1051.8	147.45	24.6	Staging of brain pathology related to sporadic Parkinson's disease.	Heiko Braak, Kelly Del Tredici, Udo Rüb, Rob A I de Vos, Ernst N H Jansen Steur, Eva Braak	Neurobiol Aging	2003	12498954	Yes
3578	2103	1051.5	0.0	0.0	A microcolorimetric method for the determination of inorganic phosphorus.	H H Taussky, E Shorr	J Biol Chem	1953	13061491	Yes
3579	1051	1051.0	24.75	24.8	BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data.	O Gascuel	Mol Biol Evol	1997	9254330	Yes
3580	1051	1051.0	26.2	26.2	Seed Germination and Dormancy.	J. D. Bewley	Plant Cell	1997	12237375	Yes
3581	1051	1051.0	28.38	28.4	Invited review: Aging and sarcopenia.	Timothy J Doherty	J Appl Physiol (1985)	2003	12970377	No
3582	2102	1051.0	51.99	26.0	ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis.	Benoît D'Autréaux, Michel B Toledano	Nat Rev Mol Cell Biol	2007	17848967	No
3583	6303	1050.5	164.34	27.4	The capsaicin receptor: a heat-activated ion channel in the pain pathway.	M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D Julius	Nature	1997	9349813	Yes
3584	1050	1050.0	23.82	23.8	The inducible transcription activator NF-kappa B: regulation by distinct protein subunits.	P A Baeuerle	Biochim Biophys Acta	1991	2018779	No
3585	1050	1050.0	0.0	0.0	Cell communication, calcium ion, and cyclic adenosine monophosphate.	H Rasmussen	Science	1970	4318972	Yes
3586	2099	1049.5	44.92	22.5	The immunoglobulin superfamily--domains for cell surface recognition.	A F Williams, A N Barclay	Annu Rev Immunol	1988	3289571	No
3587	6296	1049.3	139.07	23.2	Obesity is associated with macrophage accumulation in adipose tissue.	Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W Ferrante	J Clin Invest	2003	14679176	Yes
3588	5246	1049.2	258.9	51.8	BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs.	Felipe A Simão, Robert M Waterhouse, Panagiotis Ioannidis, Evgenia V Kriventseva, Evgeny M Zdobnov	Bioinformatics	2015	26059717	Yes
3589	4196	1049.0	108.85	27.2	A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V.	I Vermes, C Haanen, H Steffens-Nakken, C Reutelingsperger	J Immunol Methods	1995	7622868	Yes
3590	1049	1049.0	43.28	43.3	Toward terminological, conceptual, and statistical clarity in the study of mediators and moderators: examples from the child-clinical and pediatric psychology literatures.	G N Holmbeck	J Consult Clin Psychol	1997	9256561	Yes
3591	3147	1049.0	74.6	24.9	Prediction of total genetic value using genome-wide dense marker maps.	T H Meuwissen, B J Hayes, M E Goddard	Genetics	2001	11290733	Yes
3592	1049	1049.0	23.55	23.6	r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock.	Michael J Sanderson	Bioinformatics	2003	12538260	Yes
3593	1049	1049.0	29.23	29.2	Ion suppression in mass spectrometry.	Thomas M Annesley	Clin Chem	2003	12816898	No
3594	2097	1048.5	53.27	26.6	The regulation and function of c-fos and other immediate early genes in the nervous system.	M Sheng, M E Greenberg	Neuron	1990	1969743	No
3595	2097	1048.5	56.73	28.4	Localized surface plasmon resonance spectroscopy and sensing.	Katherine A Willets, Richard P Van Duyne	Annu Rev Phys Chem	2007	17067281	No
3596	2096	1048.0	77.48	38.7	Fingerprinting genomes using PCR with arbitrary primers.	J Welsh, M McClelland	Nucleic Acids Res	1990	2259619	Yes
3597	2096	1048.0	54.19	27.1	Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis.	D C Schwartz, C R Cantor	Cell	1984	6373014	Yes
3598	1048	1048.0	51.67	51.7	Transcriptional architecture of the mammalian circadian clock.	Joseph S Takahashi	Nat Rev Genet	2017	27990019	No
3599	5238	1047.6	193.88	38.8	DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates.	O Folmer, M Black, W Hoeh, R Lutz, R Vrijenhoek	Mol Mar Biol Biotechnol	1994	7881515	Yes
3600	2095	1047.5	44.2	22.1	Learning the parts of objects by non-negative matrix factorization.	D D Lee, H S Seung	Nature	1999	10548103	Yes
3601	3142	1047.3	80.53	26.8	Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions.	M Piotto, V Saudek, V Sklenár	J Biomol NMR	1992	1490109	Yes
3602	6283	1047.2	188.26	31.4	Genome engineering using the CRISPR-Cas9 system.	F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott, Feng Zhang	Nat Protoc	2013	24157548	Yes
3603	1047	1047.0	0.0	0.0	Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase.	Y Kono	Arch Biochem Biophys	1978	24422	Yes
3604	2094	1047.0	61.94	31.0	Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis.	C N Hales, D J Barker	Diabetologia	1992	1644236	No
3605	2094	1047.0	0.0	0.0	Mental rotation of three-dimensional objects.	R N Shepard, J Metzler	Science	1971	5540314	Yes
3606	1047	1047.0	32.88	32.9	Food reward: brain substrates of wanting and liking.	K C Berridge	Neurosci Biobehav Rev	1996	8622814	No
3607	2094	1047.0	42.38	21.2	IAP family proteins--suppressors of apoptosis.	Q L Deveraux, J C Reed	Genes Dev	1999	9990849	No
3608	1047	1047.0	38.55	38.5	Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls?	Fay B Horak	Age Ageing	2006	16926210	No
3609	2094	1047.0	65.66	32.8	bold: The Barcode of Life Data System (http://www.barcodinglife.org).	Sujeevan Ratnasingham, Paul D N Hebert	Mol Ecol Notes	2007	18784790	Yes
3610	2093	1046.5	59.68	29.8	Burden of major musculoskeletal conditions.	Anthony D Woolf, Bruce Pfleger	Bull World Health Organ	2003	14710506	No
3611	1046	1046.0	0.0	0.0	Carcinoid tumors. An analysis of 2,837 cases.	J D Godwin	Cancer	1975	1157019	Yes
3612	1046	1046.0	29.0	29.0	Synchronization of cortical activity and its putative role in information processing and learning.	W Singer	Annu Rev Physiol	1993	8466179	No
3613	1046	1046.0	26.42	26.4	The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease.	David S Ludwig	JAMA	2002	11988062	No
3614	1046	1046.0	28.17	28.2	Time is brain--quantified.	Jeffrey L Saver	Stroke	2006	16339467	Yes
3615	3138	1046.0	74.66	24.9	Obesity induces a phenotypic switch in adipose tissue macrophage polarization.	Carey N Lumeng, Jennifer L Bodzin, Alan R Saltiel	J Clin Invest	2007	17200717	Yes
3616	2092	1046.0	90.66	45.3	Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.	Ulrich M Zanger, Matthias Schwab	Pharmacol Ther	2013	23333322	No
3617	4180	1045.0	0.0	0.0	T cell growth factor: parameters of production and a quantitative microassay for activity.	S Gillis, M M Ferm, W Ou, K A Smith	J Immunol	1978	307029	Yes
3618	1045	1045.0	40.91	40.9	Amyloid deposits and amyloidosis: the beta-fibrilloses (second of two parts).	G G Glenner	N Engl J Med	1980	6990257	No
3619	1045	1045.0	30.7	30.7	Microbial heavy-metal resistance.	D H Nies	Appl Microbiol Biotechnol	1999	10422221	No
3620	1045	1045.0	19.07	19.1	The Pezcoller lecture: cancer cell cycles revisited.	C J Sherr	Cancer Res	2000	10919634	No
3621	1045	1045.0	24.21	24.2	Viruses in the sea.	Curtis A Suttle	Nature	2005	16163346	No
3622	1045	1045.0	33.7	33.7	Lanthanide luminescence for biomedical analyses and imaging.	Jean-Claude G Bünzli	Chem Rev	2010	20151630	No
3623	2089	1044.5	79.0	39.5	A psychomotor stimulant theory of addiction.	R A Wise, M A Bozarth	Psychol Rev	1987	3317472	No
3624	1044	1044.0	35.05	35.0	Fever: role of pyrogens and cryogens.	M J Kluger	Physiol Rev	1991	1986393	No
3625	2088	1044.0	81.75	40.9	Glutathione reductase.	I Carlberg, B Mannervik	Methods Enzymol	1985	3003504	Yes
3626	1044	1044.0	0.0	0.0	Retention of differentiation potentialities during prolonged cultivation of myogenic cells.	D Yaffe	Proc Natl Acad Sci U S A	1968	5245982	Yes
3627	2088	1044.0	52.38	26.2	Quorum sensing: cell-to-cell communication in bacteria.	Christopher M Waters, Bonnie L Bassler	Annu Rev Cell Dev Biol	2005	16212498	No
3628	1044	1044.0	25.36	25.4	Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases.	Thomas A Wynn	J Clin Invest	2007	17332879	No
3629	2088	1044.0	62.03	31.0	Metabolic reprogramming: a cancer hallmark even warburg did not anticipate.	Patrick S Ward, Craig B Thompson	Cancer Cell	2012	22439925	No
3630	2087	1043.5	59.3	29.6	Mechanisms of mitophagy.	Richard J Youle, Derek P Narendra	Nat Rev Mol Cell Biol	2011	21179058	No
3631	6258	1043.0	161.35	26.9	Ghrelin is a growth-hormone-releasing acylated peptide from stomach.	M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K Kangawa	Nature	1999	10604470	Yes
3632	1043	1043.0	37.03	37.0	Globalization of diabetes: the role of diet, lifestyle, and genes.	Frank B Hu	Diabetes Care	2011	21617109	No
3633	1043	1043.0	0.0	0.0	Cell deaths in normal vertebrate ontogeny.	A Glucksmann	Biol Rev Camb Philos Soc	1951	24540363	Yes
3634	2085	1042.5	66.17	33.1	Antiseptics and disinfectants: activity, action, and resistance.	G McDonnell, A D Russell	Clin Microbiol Rev	1999	9880479	No
3635	1042	1042.0	32.26	32.3	Prevention of drug access to bacterial targets: permeability barriers and active efflux.	H Nikaido	Science	1994	8153625	No
3636	1042	1042.0	41.06	41.1	Gait changes in older adults: predictors of falls or indicators of fear.	B E Maki	J Am Geriatr Soc	1997	9063277	Yes
3637	1042	1042.0	18.74	18.7	Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions.	W Kolch	Biochem J	2000	11023813	No
3638	1042	1042.0	26.84	26.8	The potential environmental impact of engineered nanomaterials.	Vicki L Colvin	Nat Biotechnol	2003	14520401	Yes
3639	2083	1041.5	0.0	0.0	Severe psoriasis--oral therapy with a new retinoid.	T Fredriksson, U Pettersson	Dermatologica	1978	357213	Yes
3640	2083	1041.5	40.58	20.3	Improved retroviral vectors for gene transfer and expression.	A D Miller, G J Rosman	Biotechniques	1989	2631796	Yes
3641	2083	1041.5	51.14	25.6	Efficient isolation of genes by using antibody probes.	R A Young, R W Davis	Proc Natl Acad Sci U S A	1983	6219389	Yes
3642	1041	1041.0	35.42	35.4	Lipid peroxidation and antioxidants as biomarkers of tissue damage.	J M Gutteridge	Clin Chem	1995	7497639	No
3643	1041	1041.0	25.71	25.7	The sphingomyelin cycle and the second messenger function of ceramide.	Y A Hannun	J Biol Chem	1994	8106344	No
3644	3123	1041.0	66.18	22.1	TGF-beta signalling from cell membrane to nucleus through SMAD proteins.	C H Heldin, K Miyazono, P ten Dijke	Nature	1997	9393997	No
3645	1041	1041.0	25.92	25.9	Biological effects of resveratrol.	L Frémont	Life Sci	2000	10680575	No
3646	3123	1041.0	62.3	20.8	Release of chromatin protein HMGB1 by necrotic cells triggers inflammation.	Paola Scaffidi, Tom Misteli, Marco E Bianchi	Nature	2002	12110890	Yes
3647	1041	1041.0	29.25	29.2	Cholinesterase inhibitors for Alzheimer's disease.	J Birks	Cochrane Database Syst Rev	2006	16437532	No
3648	1041	1041.0	41.96	42.0	Glutathione synthesis.	Shelly C Lu	Biochim Biophys Acta	2013	22995213	No
3649	3122	1040.7	75.84	25.3	Nitric oxide and macrophage function.	J MacMicking, Q W Xie, C Nathan	Annu Rev Immunol	1997	9143691	No
3650	2081	1040.5	58.85	29.4	ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control.	Graham Noctor, Christine H. Foyer	Annu Rev Plant Physiol Plant Mol Biol	1998	15012235	Yes
3651	3121	1040.3	77.47	25.8	Mechanisms linking obesity to insulin resistance and type 2 diabetes.	Steven E Kahn, Rebecca L Hull, Kristina M Utzschneider	Nature	2006	17167471	No
3652	3121	1040.3	0.0	0.0	Therapeutic criteria in rheumatoid arthritis.	O Steinbrocker, C H Traeger, R C Batterman	J Am Med Assoc	1949	18150288	Yes
3653	1040	1040.0	27.8	27.8	Human TH1 and TH2 subsets: doubt no more.	S Romagnani	Immunol Today	1991	1680337	Yes
3654	1040	1040.0	35.24	35.2	High density lipoprotein metabolism.	S Eisenberg	J Lipid Res	1984	6392459	No
3655	3120	1040.0	97.73	32.6	Evaluating the public health impact of health promotion interventions: the RE-AIM framework.	R E Glasgow, T M Vogt, S M Boles	Am J Public Health	1999	10474547	No
3656	1040	1040.0	34.83	34.8	Starting at the beginning: an introduction to coefficient alpha and internal consistency.	David L Streiner	J Pers Assess	2003	12584072	Yes
3657	2080	1040.0	48.97	24.5	The host defense of Drosophila melanogaster.	Bruno Lemaitre, Jules Hoffmann	Annu Rev Immunol	2007	17201680	No
3658	1040	1040.0	27.13	27.1	Immortal time bias in pharmaco-epidemiology.	Samy Suissa	Am J Epidemiol	2008	18056625	No
3659	4159	1039.8	100.68	25.2	The epidemiology of sepsis in the United States from 1979 through 2000.	Greg S Martin, David M Mannino, Stephanie Eaton, Marc Moss	N Engl J Med	2003	12700374	Yes
3660	3119	1039.7	63.31	21.1	SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.	Jay D Horton, Joseph L Goldstein, Michael S Brown	J Clin Invest	2002	11994399	No
3661	3118	1039.3	61.36	20.5	Genetic instabilities in human cancers.	C Lengauer, K W Kinzler, B Vogelstein	Nature	1998	9872311	No
3662	1039	1039.0	22.13	22.1	Molecular cloning and expression of glycogen synthase kinase-3/factor A.	J R Woodgett	EMBO J	1990	2164470	Yes
3663	1039	1039.0	0.0	0.0	Lipid peroxidation damage to cell components.	A L Tappel	Fed Proc	1973	4352451	Yes
3664	1039	1039.0	22.29	22.3	Twilight zone of protein sequence alignments.	B Rost	Protein Eng	1999	10195279	Yes
3665	1039	1039.0	28.17	28.2	Bacteroides: the good, the bad, and the nitty-gritty.	Hannah M Wexler	Clin Microbiol Rev	2007	17934076	No
3666	1039	1039.0	26.51	26.5	Correlates of protection induced by vaccination.	Stanley A Plotkin	Clin Vaccine Immunol	2010	20463105	No
3667	1038	1038.0	56.27	56.3	The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement.	M M Panjabi	J Spinal Disord	1992	1490034	Yes
3668	1038	1038.0	42.67	42.7	Movement, posture and equilibrium: interaction and coordination.	J Massion	Prog Neurobiol	1992	1736324	No
3669	2076	1038.0	0.0	0.0	A simple method for the preparation of 32-P-labelled adenosine triphosphate of high specific activity.	I M Glynn, J B Chappell	Biochem J	1964	5832284	Yes
3670	1038	1038.0	0.0	0.0	The interaction of a naphthalene dye with apomyoglobin and apohemoglobin. A fluorescent probe of non-polar binding sites.	L Stryer	J Mol Biol	1965	5867031	Yes
3671	1038	1038.0	0.0	0.0	Why people use health services.	I M Rosenstock	Milbank Mem Fund Q	1966	5967464	Yes
3672	1038	1038.0	32.34	32.3	Selective modification of glutathione metabolism.	A Meister	Science	1983	6836290	Yes
3673	4152	1038.0	105.21	26.3	An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets.	Joseph A Maldjian, Paul J Laurienti, Robert A Kraft, Jonathan H Burdette	Neuroimage	2003	12880848	Yes
3674	2076	1038.0	0.0	0.0	A modified ninhydrin reagent for the photometric determination of amino acids and related compounds.	S Moore, W H Stein	J Biol Chem	1954	13221596	Yes
3675	1038	1038.0	21.05	21.1	Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution.	Mats G L Gustafsson	Proc Natl Acad Sci U S A	2005	16141335	Yes
3676	1037	1037.0	0.0	0.0	Clinical experience with impedance audiometry.	J Jerger	Arch Otolaryngol	1970	5455571	Yes
3677	1037	1037.0	0.0	0.0	The nature and significance of platelet products in human plasma.	P Wolf	Br J Haematol	1967	6025241	Yes
3678	2074	1037.0	38.99	19.5	AP-1 as a regulator of cell life and death.	Eitan Shaulian, Michael Karin	Nat Cell Biol	2002	11988758	No
3679	1037	1037.0	25.2	25.2	Context, ambiguity, and unlearning: sources of relapse after behavioral extinction.	Mark E Bouton	Biol Psychiatry	2002	12437938	No
3680	1037	1037.0	21.0	21.0	Automated NMR structure calculation with CYANA.	Peter Güntert	Methods Mol Biol	2004	15318003	Yes
3681	4145	1036.2	84.58	21.1	Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells.	E Schreiber, P Matthias, M M Müller, W Schaffner	Nucleic Acids Res	1989	2771659	Yes
3682	1036	1036.0	39.26	39.3	The ovariectomized rat model of postmenopausal bone loss.	D N Kalu	Bone Miner	1991	1773131	No
3683	1036	1036.0	0.0	0.0	The moulding of senescence by natural selection.	W D Hamilton	J Theor Biol	1966	6015424	Yes
3684	1036	1036.0	19.88	19.9	Initiation of translation in prokaryotes and eukaryotes.	M Kozak	Gene	1999	10395892	No
3685	1036	1036.0	33.52	33.5	Isolation By Distance In Equilibrium And Non-Equilibrium Populations.	Montgomery Slatkin	Evolution	1993	28568097	Yes
3686	2071	1035.5	59.84	29.9	Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia.	Amit Etkin, Tor D Wager	Am J Psychiatry	2007	17898336	Yes
3687	1035	1035.0	0.0	0.0	Transformation of yeast by a replicating hybrid plasmid.	J D Beggs	Nature	1978	357984	Yes
3688	2070	1035.0	0.0	0.0	Analysis of probability as an aid in the clinical diagnosis of coronary-artery disease.	G A Diamond, J S Forrester	N Engl J Med	1979	440357	Yes
3689	1035	1035.0	0.0	0.0	Surface modulation in cell recognition and cell growth.	G M Edelman	Science	1976	769162	No
3690	1035	1035.0	0.0	0.0	Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system.	U Ungerstedt	Acta Physiol Scand Suppl	1971	4332694	Yes
3691	1035	1035.0	28.32	28.3	Presynaptic nicotinic ACh receptors.	S Wonnacott	Trends Neurosci	1997	9023878	No
3692	1035	1035.0	25.63	25.6	Looking into the functional architecture of the brain with diffusion MRI.	Denis Le Bihan	Nat Rev Neurosci	2003	12778119	No
3693	1035	1035.0	0.0	0.0	Neural basis of the spontaneous optokinetic response produced by visual inversion.	R W Sperry	J Comp Physiol Psychol	1950	14794830	Yes
3694	6205	1034.2	174.07	29.0	Mild cognitive impairment: clinical characterization and outcome.	R C Petersen, G E Smith, S C Waring, R J Ivnik, E G Tangalos, E Kokmen	Arch Neurol	1999	10190820	Yes
3695	3102	1034.0	79.93	26.6	Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).	R S Spielman, R E McGinnis, W J Ewens	Am J Hum Genet	1993	8447318	Yes
3696	1034	1034.0	23.62	23.6	Natural history of chronic hepatitis C.	Leonard B Seeff	Hepatology	2002	12407575	No
3697	1034	1034.0	0.0	0.0	On the prediction of occurrence of particular verbal intrusions in immediate recall.	J Deese	J Exp Psychol	1959	13664879	Yes
3698	8270	1033.8	324.07	40.5	Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey.	R C Kessler, K A McGonagle, S Zhao, C B Nelson, M Hughes, S Eshleman, H U Wittchen, K S Kendler	Arch Gen Psychiatry	1994	8279933	Yes
3699	3100	1033.3	123.83	41.3	Concurrent and predictive validity of a self-reported measure of medication adherence.	D E Morisky, L W Green, D M Levine	Med Care	1986	3945130	Yes
3700	1033	1033.0	30.32	30.3	Cytochrome oxidase: an endogenous metabolic marker for neuronal activity.	M T Wong-Riley	Trends Neurosci	1989	2469224	No

_{Unicorn Papers}

Top ‱ cited papers from PUBMED

Volume 32, April 2023