Unicorn Papers - Top cited papers from PUBMED

No.	Citations	EC_cit	RCR	EC_RCR	Title	Authors	Journal	Year	PMID	Article(?)
1	222460	222460.0	0.0	0.0	Cleavage of structural proteins during the assembly of the head of bacteriophage T4.	U K Laemmli	Nature	1970	5432063	Yes
2	169675	169675.0	0.0	0.0	A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.	M M Bradford	Anal Biochem	1976	942051	Yes
3	284270	71067.5	0.0	0.0	Protein measurement with the Folin phenol reagent.	O H Lowry, N J Rosebrough, A L Farr, R J Randall	J Biol Chem	1951	14907713	Yes
4	103638	51819.0	2639.45	1319.7	Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.	K J Livak, T D Schmittgen	Methods	2001	11846609	Yes
5	43734	43734.0	1433.25	1433.2	A short history of SHELX.	George M Sheldrick	Acta Crystallogr A	2008	18156677	Yes
6	34574	34574.0	1119.8	1119.8	Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.	T Mosmann	J Immunol Methods	1983	6606682	Yes
7	65123	32561.5	1969.98	985.0	Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.	P Chomczynski, N Sacchi	Anal Biochem	1987	2440339	Yes
8	30201	30201.0	0.0	0.0	Detection of specific sequences among DNA fragments separated by gel electrophoresis.	E M Southern	J Mol Biol	1975	1195397	Yes
9	26130	26130.0	0.0	0.0	The assessment and analysis of handedness: the Edinburgh inventory.	R C Oldfield	Neuropsychologia	1971	5146491	Yes
10	25888	25888.0	590.68	590.7	MicroRNAs: genomics, biogenesis, mechanism, and function.	David P Bartel	Cell	2004	14744438	No
11	24215	24215.0	0.0	0.0	A rating scale for depression.	M Hamilton	J Neurol Neurosurg Psychiatry	1960	14399272	Yes
12	23059	23059.0	722.98	723.0	Confidence Limits On Phylogenies: An Approach Using The Bootstrap.	Joseph Felsenstein	Evolution	1985	28561359	Yes
13	22997	22997.0	563.42	563.4	MUSCLE: multiple sequence alignment with high accuracy and high throughput.	Robert C Edgar	Nucleic Acids Res	2004	15034147	Yes
14	22320	22320.0	525.04	525.0	A new mathematical model for relative quantification in real-time RT-PCR.	M W Pfaffl	Nucleic Acids Res	2001	11328886	Yes
15	65532	21844.0	0.0	0.0	DNA sequencing with chain-terminating inhibitors.	F Sanger, S Nicklen, A R Coulson	Proc Natl Acad Sci U S A	1977	271968	Yes
16	62074	20691.3	0.0	0.0	"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician.	M F Folstein, S E Folstein, P R McHugh	J Psychiatr Res	1975	1202204	Yes
17	20040	20040.0	0.0	0.0	The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.	E S Reynolds	J Cell Biol	1963	13986422	Yes
18	19087	19087.0	673.18	673.2	Density-functional exchange-energy approximation with correct asymptotic behavior.	Becke	Phys Rev A Gen Phys	1988	9900728	Yes
19	37687	18843.5	1168.79	584.4	The neighbor-joining method: a new method for reconstructing phylogenetic trees.	N Saitou, M Nei	Mol Biol Evol	1987	3447015	Yes
20	18546	18546.0	0.0	0.0	Tissue sulfhydryl groups.	G L Ellman	Arch Biochem Biophys	1959	13650640	Yes
21	35540	17770.0	1216.89	608.4	Hallmarks of cancer: the next generation.	Douglas Hanahan, Robert A Weinberg	Cell	2011	21376230	No
22	53249	17749.7	0.0	0.0	Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.	H Towbin, T Staehelin, J Gordon	Proc Natl Acad Sci U S A	1979	388439	Yes
23	33810	16905.0	1628.93	814.5	Statistical methods for assessing agreement between two methods of clinical measurement.	J M Bland, D G Altman	Lancet	1986	2868172	Yes
24	16805	16805.0	0.0	0.0	Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins.	B J Davis	Ann N Y Acad Sci	1964	14240539	Yes
25	16364	16364.0	421.61	421.6	Atherosclerosis--an inflammatory disease.	R Ross	N Engl J Med	1999	9887164	No
26	16192	16192.0	0.0	0.0	High resolution two-dimensional electrophoresis of proteins.	P H O'Farrell	J Biol Chem	1975	236308	Yes
27	15909	15909.0	0.0	0.0	A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.	K Burton	Biochem J	1956	13293190	Yes
28	15899	15899.0	593.53	593.5	A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences.	M Kimura	J Mol Evol	1980	7463489	Yes
29	31030	15515.0	0.0	0.0	A rapid method of total lipid extraction and purification.	E G Bligh, W J Dyer	Can J Biochem Physiol	1959	13671378	Yes
30	30262	15131.0	0.0	0.0	The measurement of observer agreement for categorical data.	J R Landis, G G Koch	Biometrics	1977	843571	Yes
31	43958	14652.7	1266.13	422.0	CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.	J D Thompson, D G Higgins, T J Gibson	Nucleic Acids Res	1994	7984417	Yes
32	14502	14502.0	425.51	425.5	Projector augmented-wave method.	Blöchl	Phys Rev B Condens Matter	1994	9976227	Yes
33	14140	14140.0	379.08	379.1	MicroRNAs: target recognition and regulatory functions.	David P Bartel	Cell	2009	19167326	No
34	40734	13578.0	0.0	0.0	A simple method for the isolation and purification of total lipides from animal tissues.	J Folch, M Lees, G H Sloane Stanley	J Biol Chem	1957	13428781	Yes
35	13531	13531.0	568.74	568.7	A power primer.	J Cohen	Psychol Bull	1992	19565683	Yes
36	26822	13411.0	1030.85	515.4	Meta-analysis in clinical trials.	R DerSimonian, N Laird	Control Clin Trials	1986	3802833	Yes
37	26521	13260.5	1095.34	547.7	The hospital anxiety and depression scale.	A S Zigmond, R P Snaith	Acta Psychiatr Scand	1983	6880820	Yes
38	13194	13194.0	649.78	649.8	RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies.	Alexandros Stamatakis	Bioinformatics	2014	24451623	Yes
39	12713	12713.0	502.54	502.5	Catalase in vitro.	H Aebi	Methods Enzymol	1984	6727660	Yes
40	12617	12617.0	0.0	0.0	Phosphorus assay in column chromatography.	G R Bartlett	J Biol Chem	1959	13641241	Yes
41	37186	12395.3	1145.6	381.9	Generalized Gradient Approximation Made Simple.	Perdew, Burke, Ernzerhof	Phys Rev Lett	1996	10062328	Yes
42	23123	11561.5	628.28	314.1	Fast and accurate short read alignment with Burrows-Wheeler transform.	Heng Li, Richard Durbin	Bioinformatics	2009	19451168	Yes
43	57580	11516.0	1663.8	332.8	Basic local alignment search tool.	S F Altschul, W Gish, W Miller, E W Myers, D J Lipman	J Mol Biol	1990	2231712	Yes
44	33810	11270.0	1227.59	409.2	Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density.	Lee, Yang, Parr	Phys Rev B Condens Matter	1988	9944570	Yes
45	22505	11252.5	946.15	473.1	The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection.	J E Ware, C D Sherbourne	Med Care	1992	1593914	Yes
46	22370	11185.0	484.78	242.4	Coot: model-building tools for molecular graphics.	Paul Emsley, Kevin Cowtan	Acta Crystallogr D Biol Crystallogr	2004	15572765	Yes
47	22055	11027.5	779.27	389.6	Fast gapped-read alignment with Bowtie 2.	Ben Langmead, Steven L Salzberg	Nat Methods	2012	22388286	Yes
48	21563	10781.5	560.06	280.0	A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.	A P Feinberg, B Vogelstein	Anal Biochem	1983	6312838	Yes
49	10774	10774.0	361.97	362.0	Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS).	J F Kurtzke	Neurology	1983	6685237	Yes
50	10733	10733.0	379.23	379.2	Search and clustering orders of magnitude faster than BLAST.	Robert C Edgar	Bioinformatics	2010	20709691	Yes
51	10504	10504.0	0.0	0.0	The genetics of Caenorhabditis elegans.	S Brenner	Genetics	1974	4366476	Yes
52	20746	10373.0	462.9	231.4	[20] Processing of X-ray diffraction data collected in oscillation mode.	Zbyszek Otwinowski, Wladek Minor	Methods Enzymol	1997	27799103	Yes
53	10349	10349.0	288.85	288.9	Xds.	Wolfgang Kabsch	Acta Crystallogr D Biol Crystallogr	2010	20124692	Yes
54	10335	10335.0	0.0	0.0	Improvements in epoxy resin embedding methods.	J H Luft	J Biophys Biochem Cytol	1961	13764136	Yes
55	10331	10331.0	316.77	316.8	The Psychophysics Toolbox.	D H Brainard	Spat Vis	1997	9176952	Yes
56	10209	10209.0	382.54	382.5	Structure validation in chemical crystallography.	Anthony L Spek	Acta Crystallogr D Biol Crystallogr	2009	19171970	Yes
57	10113	10113.0	627.02	627.0	Crystal structure refinement with SHELXL.	George M Sheldrick	Acta Crystallogr C Struct Chem	2015	25567568	Yes
58	10022	10022.0	0.0	0.0	Self-efficacy: toward a unifying theory of behavioral change.	A Bandura	Psychol Rev	1977	847061	Yes
59	19780	9890.0	0.0	0.0	The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.	K Weber, M Osborn	J Biol Chem	1969	5806584	Yes
60	9681	9681.0	378.12	378.1	A new method for measuring daytime sleepiness: the Epworth sleepiness scale.	M W Johns	Sleep	1991	1798888	Yes
61	19052	9526.0	533.32	266.7	Quantifying heterogeneity in a meta-analysis.	Julian P T Higgins, Simon G Thompson	Stat Med	2002	12111919	Yes
62	18912	9456.0	544.93	272.5	Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set.	Kresse, Furthmüller	Phys Rev B Condens Matter	1996	9984901	Yes
63	9451	9451.0	321.65	321.6	Banting lecture 1988. Role of insulin resistance in human disease.	G M Reaven	Diabetes	1988	3056758	No
64	18520	9260.0	831.39	415.7	The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations.	R M Baron, D A Kenny	J Pers Soc Psychol	1986	3806354	Yes
65	9256	9256.0	269.47	269.5	Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.	P S Thomas	Proc Natl Acad Sci U S A	1980	6159641	Yes
66	18371	9185.5	481.84	240.9	A simple method for displaying the hydropathic character of a protein.	J Kyte, R F Doolittle	J Mol Biol	1982	7108955	Yes
67	9166	9166.0	243.69	243.7	Studies on transformation of Escherichia coli with plasmids.	D Hanahan	J Mol Biol	1983	6345791	Yes
68	9098	9098.0	260.57	260.6	The pathogenesis of atherosclerosis: a perspective for the 1990s.	R Ross	Nature	1993	8479518	No
69	8985	8985.0	235.83	235.8	Integrins: versatility, modulation, and signaling in cell adhesion.	R O Hynes	Cell	1992	1555235	No
70	8844	8844.0	252.98	253.0	Evolutionary trees from DNA sequences: a maximum likelihood approach.	J Felsenstein	J Mol Evol	1981	7288891	Yes
71	8840	8840.0	191.9	191.9	Mfold web server for nucleic acid folding and hybridization prediction.	Michael Zuker	Nucleic Acids Res	2003	12824337	Yes
72	8789	8789.0	0.0	0.0	On the origin of cancer cells.	O Warburg	Science	1956	13298683	Yes
73	26158	8719.3	696.04	232.0	VMD: visual molecular dynamics.	W Humphrey, A Dalke, K Schulten	J Mol Graph	1996	8744570	Yes
74	8703	8703.0	235.98	236.0	RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models.	Alexandros Stamatakis	Bioinformatics	2006	16928733	Yes
75	25981	8660.3	1096.08	365.4	Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.	Michael I Love, Wolfgang Huber, Simon Anders	Genome Biol	2014	25516281	Yes
76	8598	8598.0	263.43	263.4	Vitamin D deficiency.	Michael F Holick	N Engl J Med	2007	17634462	No
77	34147	8536.8	1016.08	254.0	Measuring inconsistency in meta-analyses.	Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman	BMJ	2003	12958120	No
78	33904	8476.0	1413.37	353.3	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	PLoS Med	2009	19621072	No
79	16861	8430.5	365.48	182.7	The hallmarks of cancer.	D Hanahan, R A Weinberg	Cell	2000	10647931	No
80	8341	8341.0	175.68	175.7	Linear models and empirical bayes methods for assessing differential expression in microarray experiments.	Gordon K Smyth	Stat Appl Genet Mol Biol	2004	16646809	Yes
81	8228	8228.0	366.42	366.4	Psychophysical bases of perceived exertion.	G A Borg	Med Sci Sports Exerc	1982	7154893	Yes
82	8121	8121.0	231.67	231.7	Semiempirical GGA-type density functional constructed with a long-range dispersion correction.	Stefan Grimme	J Comput Chem	2006	16955487	Yes
83	8033	8033.0	175.92	175.9	The functions of animal microRNAs.	Victor Ambros	Nature	2004	15372042	No
84	8009	8009.0	0.0	0.0	Solvent content of protein crystals.	B W Matthews	J Mol Biol	1968	5700707	Yes
85	7896	7896.0	300.18	300.2	Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses.	Andreas Stang	Eur J Epidemiol	2010	20652370	Yes
86	31428	7857.0	1200.26	300.1	A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.	M E Charlson, P Pompei, K L Ales, C R MacKenzie	J Chronic Dis	1987	3558716	Yes
87	7833	7833.0	0.0	0.0	Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris.	D I Arnon	Plant Physiol	1949	16654194	Yes
88	7823	7823.0	210.03	210.0	Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.	M C Hochberg	Arthritis Rheum	1997	9324032	Yes
89	23452	7817.3	876.44	292.1	NIH Image to ImageJ: 25 years of image analysis.	Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri	Nat Methods	2012	22930834	No
90	7787	7787.0	218.35	218.3	The role of protein kinase C in cell surface signal transduction and tumour promotion.	Y Nishizuka	Nature	1984	6232463	No
91	7778	7778.0	218.55	218.6	"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.	W N Burnette	Anal Biochem	1981	6266278	Yes
92	15515	7757.5	359.8	179.9	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.	Kazutoshi Takahashi, Shinya Yamanaka	Cell	2006	16904174	Yes
93	23261	7753.7	639.44	213.1	Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.	Da Wei Huang, Brad T Sherman, Richard A Lempicki	Nat Protoc	2009	19131956	Yes
94	7722	7722.0	0.0	0.0	A simplification of the protein assay method of Lowry et al. which is more generally applicable.	G L Peterson	Anal Biochem	1977	603028	Yes
95	7580	7580.0	0.0	0.0	Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.	J R Vane	Nat New Biol	1971	5284360	Yes
96	7529	7529.0	245.73	245.7	The blockade of immune checkpoints in cancer immunotherapy.	Drew M Pardoll	Nat Rev Cancer	2012	22437870	No
97	29634	7408.5	980.58	245.1	Bias in meta-analysis detected by a simple, graphical test.	M Egger, G Davey Smith, M Schneider, C Minder	BMJ	1997	9310563	Yes
98	22159	7386.3	1003.76	334.6	Trimmomatic: a flexible trimmer for Illumina sequence data.	Anthony M Bolger, Marc Lohse, Bjoern Usadel	Bioinformatics	2014	24695404	Yes
99	14767	7383.5	643.72	321.9	MAFFT multiple sequence alignment software version 7: improvements in performance and usability.	Kazutaka Katoh, Daron M Standley	Mol Biol Evol	2013	23329690	Yes
100	14722	7361.0	410.75	205.4	Analyzing real-time PCR data by the comparative C(T) method.	Thomas D Schmittgen, Kenneth J Livak	Nat Protoc	2008	18546601	Yes
101	7332	7332.0	334.0	334.0	Investigation of the freely available easy-to-use software 'EZR' for medical statistics.	Y Kanda	Bone Marrow Transplant	2013	23208313	Yes
102	7313	7313.0	199.68	199.7	Canonical dynamics: Equilibrium phase-space distributions.	Hoover	Phys Rev A Gen Phys	1985	9895674	Yes
103	7275	7275.0	0.0	0.0	A low-viscosity epoxy resin embedding medium for electron microscopy.	A R Spurr	J Ultrastruct Res	1969	4887011	Yes
104	7273	7273.0	0.0	0.0	Tumor angiogenesis: therapeutic implications.	J Folkman	N Engl J Med	1971	4938153	No
105	14541	7270.5	364.46	182.2	MrBayes 3: Bayesian phylogenetic inference under mixed models.	Fredrik Ronquist, John P Huelsenbeck	Bioinformatics	2003	12912839	Yes
106	7221	7221.0	183.42	183.4	PAML 4: phylogenetic analysis by maximum likelihood.	Ziheng Yang	Mol Biol Evol	2007	17483113	Yes
107	7220	7220.0	217.83	217.8	AFNI: software for analysis and visualization of functional magnetic resonance neuroimages.	R W Cox	Comput Biomed Res	1996	8812068	Yes
108	14333	7166.5	316.63	158.3	KEGG: kyoto encyclopedia of genes and genomes.	M Kanehisa, S Goto	Nucleic Acids Res	2000	10592173	Yes
109	7069	7069.0	240.3	240.3	Density-functional approximation for the correlation energy of the inhomogeneous electron gas.	Perdew	Phys Rev B Condens Matter	1986	9938299	Yes
110	49259	7037.0	1291.76	184.5	Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.	S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J Lipman	Nucleic Acids Res	1997	9254694	No
111	7017	7017.0	193.06	193.1	TreeView: an application to display phylogenetic trees on personal computers.	R D Page	Comput Appl Biosci	1996	8902363	Yes
112	21050	7016.7	0.0	0.0	Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.	W T Friedewald, R I Levy, D S Fredrickson	Clin Chem	1972	4337382	Yes
113	6987	6987.0	329.57	329.6	Comparative fit indexes in structural models.	P M Bentler	Psychol Bull	1990	2320703	Yes
114	6966	6966.0	157.24	157.2	Chromatin modifications and their function.	Tony Kouzarides	Cell	2007	17320507	No
115	6952	6952.0	0.0	0.0	Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.	A Böyum	Scand J Clin Lab Invest Suppl	1968	4179068	Yes
116	6921	6921.0	187.07	187.1	Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.	F Tajima	Genetics	1989	2513255	Yes
117	13694	6847.0	314.84	157.4	Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana.	S J Clough, A F Bent	Plant J	1998	10069079	Yes
118	6810	6810.0	189.16	189.2	Apoptosis: a review of programmed cell death.	Susan Elmore	Toxicol Pathol	2007	17562483	No
119	6797	6797.0	184.69	184.7	The steroid and thyroid hormone receptor superfamily.	R M Evans	Science	1988	3283939	No
120	13567	6783.5	0.0	0.0	Continuous cultures of fused cells secreting antibody of predefined specificity.	G Köhler, C Milstein	Nature	1975	1172191	Yes
121	13545	6772.5	289.32	144.7	Processing of X-ray diffraction data collected in oscillation mode.	Z Otwinowski, W Minor	Methods Enzymol	1997	27754618	Yes
122	6737	6737.0	172.12	172.1	Fast robust automated brain extraction.	Stephen M Smith	Hum Brain Mapp	2002	12391568	No
123	6715	6715.0	0.0	0.0	The assessment of anxiety states by rating.	M Hamilton	Br J Med Psychol	1959	13638508	Yes
124	6686	6686.0	0.0	0.0	The thiobarbituric acid assay of sialic acids.	L Warren	J Biol Chem	1959	13672998	Yes
125	19826	6608.7	1376.59	458.9	MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets.	Sudhir Kumar, Glen Stecher, Koichiro Tamura	Mol Biol Evol	2016	27004904	Yes
126	19677	6559.0	560.18	186.7	A new generation of Ca2+ indicators with greatly improved fluorescence properties.	G Grynkiewicz, M Poenie, R Y Tsien	J Biol Chem	1985	3838314	Yes
127	6525	6525.0	172.57	172.6	Adhesion receptors of the immune system.	T A Springer	Nature	1990	1974032	No
128	38991	6498.5	3699.71	616.6	Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.	Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal	CA Cancer J Clin	2018	30207593	Yes
129	6479	6479.0	198.95	198.9	The VideoToolbox software for visual psychophysics: transforming numbers into movies.	D G Pelli	Spat Vis	1997	9176953	Yes
130	6439	6439.0	169.37	169.4	Angiogenesis in cancer, vascular, rheumatoid and other disease.	J Folkman	Nat Med	1995	7584949	No
131	12822	6411.0	0.0	0.0	Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.	Y Cheng, W H Prusoff	Biochem Pharmacol	1973	4202581	Yes
132	6366	6366.0	130.37	130.4	Rapid and efficient site-specific mutagenesis without phenotypic selection.	T A Kunkel	Proc Natl Acad Sci U S A	1985	3881765	Yes
133	12731	6365.5	0.0	0.0	Statistical aspects of the analysis of data from retrospective studies of disease.	N Mantel, W Haenszel	J Natl Cancer Inst	1959	13655060	Yes
134	6311	6311.0	209.26	209.3	Ethical guidelines for investigations of experimental pain in conscious animals.	Manfred Zimmermann	Pain	1983	6877845	No
135	6278	6278.0	205.67	205.7	The Clinical Dementia Rating (CDR): current version and scoring rules.	J C Morris	Neurology	1993	8232972	Yes
136	6216	6216.0	135.46	135.5	p53, the cellular gatekeeper for growth and division.	A J Levine	Cell	1997	9039259	No
137	6165	6165.0	325.53	325.5	Prokka: rapid prokaryotic genome annotation.	Torsten Seemann	Bioinformatics	2014	24642063	Yes
138	6137	6137.0	297.63	297.6	UPARSE: highly accurate OTU sequences from microbial amplicon reads.	Robert C Edgar	Nat Methods	2013	23955772	Yes
139	12210	6105.0	0.0	0.0	A rapid alkaline extraction procedure for screening recombinant plasmid DNA.	H C Birnboim, J Doly	Nucleic Acids Res	1979	388356	Yes
140	6100	6100.0	125.3	125.3	Integrins: bidirectional, allosteric signaling machines.	Richard O Hynes	Cell	2002	12297042	No
141	12128	6064.0	0.0	0.0	Prediction of creatinine clearance from serum creatinine.	D W Cockcroft, M H Gault	Nephron	1976	1244564	Yes
142	6049	6049.0	150.17	150.2	Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm.	T A Springer	Cell	1994	7507411	No
143	24002	6000.5	0.0	0.0	Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.	J M Chirgwin, A E Przybyla, R J MacDonald, W J Rutter	Biochemistry	1979	518835	Yes
144	5982	5982.0	152.76	152.8	Inositol trisphosphate and calcium signalling.	M J Berridge	Nature	1993	8381210	No
145	5967	5967.0	134.94	134.9	Inflammation in atherosclerosis.	Peter Libby	Nature	2002	12490960	No
146	17854	5951.3	569.58	189.9	Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.	Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien	Ann Surg	2004	15273542	Yes
147	5946	5946.0	152.42	152.4	G proteins: transducers of receptor-generated signals.	A G Gilman	Annu Rev Biochem	1987	3113327	No
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