Unicorn Papers
Top ‱ cited papers from PUBMED
Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authorsCurrently, the list contains 3563 papers with ECcit ≥ 1011.3
‱ - permyriad,
, literally meaning "for (every) myriad (ten thousand)"
Volume 22, June 2022
| No. | Citations | ECcit | RCR | ECRCR | Title | Authors | Journal | Year | PMID | Article(?) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 222364 | 222364.0 | 0.0 | 0.0 | Cleavage of structural proteins during the assembly of the head of bacteriophage T4. | U K Laemmli | Nature | 1970 | 5432063 | Yes |
| 2 | 169609 | 169609.0 | 0.0 | 0.0 | A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. | M M Bradford | Anal Biochem | 1976 | 942051 | Yes |
| 3 | 284329 | 71082.2 | 0.0 | 0.0 | Protein measurement with the Folin phenol reagent. | O H Lowry, N J Rosebrough, A L Farr, R J Randall | J Biol Chem | 1951 | 14907713 | Yes |
| 4 | 102840 | 51420.0 | 2624.42 | 1312.2 | Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. | K J Livak, T D Schmittgen | Methods | 2001 | 11846609 | Yes |
| 5 | 43658 | 43658.0 | 1435.94 | 1435.9 | A short history of SHELX. | George M Sheldrick | Acta Crystallogr A | 2008 | 18156677 | Yes |
| 6 | 34469 | 34469.0 | 1116.6 | 1116.6 | Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. | T Mosmann | J Immunol Methods | 1983 | 6606682 | Yes |
| 7 | 65120 | 32560.0 | 1970.32 | 985.2 | Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. | P Chomczynski, N Sacchi | Anal Biochem | 1987 | 2440339 | Yes |
| 8 | 30197 | 30197.0 | 0.0 | 0.0 | Detection of specific sequences among DNA fragments separated by gel electrophoresis. | E M Southern | J Mol Biol | 1975 | 1195397 | Yes |
| 9 | 26043 | 26043.0 | 0.0 | 0.0 | The assessment and analysis of handedness: the Edinburgh inventory. | R C Oldfield | Neuropsychologia | 1971 | 5146491 | Yes |
| 10 | 25797 | 25797.0 | 589.67 | 589.7 | MicroRNAs: genomics, biogenesis, mechanism, and function. | David P Bartel | Cell | 2004 | 14744438 | No |
| 11 | 24137 | 24137.0 | 0.0 | 0.0 | A rating scale for depression. | M Hamilton | J Neurol Neurosurg Psychiatry | 1960 | 14399272 | Yes |
| 12 | 22969 | 22969.0 | 720.38 | 720.4 | Confidence Limits On Phylogenies: An Approach Using The Bootstrap. | Joseph Felsenstein | Evolution | 1985 | 28561359 | Yes |
| 13 | 22823 | 22823.0 | 560.25 | 560.2 | MUSCLE: multiple sequence alignment with high accuracy and high throughput. | Robert C Edgar | Nucleic Acids Res | 2004 | 15034147 | Yes |
| 14 | 22213 | 22213.0 | 523.62 | 523.6 | A new mathematical model for relative quantification in real-time RT-PCR. | M W Pfaffl | Nucleic Acids Res | 2001 | 11328886 | Yes |
| 15 | 65503 | 21834.3 | 0.0 | 0.0 | DNA sequencing with chain-terminating inhibitors. | F Sanger, S Nicklen, A R Coulson | Proc Natl Acad Sci U S A | 1977 | 271968 | Yes |
| 16 | 61867 | 20622.3 | 0.0 | 0.0 | "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. | M F Folstein, S E Folstein, P R McHugh | J Psychiatr Res | 1975 | 1202204 | Yes |
| 17 | 20031 | 20031.0 | 0.0 | 0.0 | The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. | E S Reynolds | J Cell Biol | 1963 | 13986422 | Yes |
| 18 | 19005 | 19005.0 | 670.75 | 670.8 | Density-functional exchange-energy approximation with correct asymptotic behavior. | Becke | Phys Rev A Gen Phys | 1988 | 9900728 | Yes |
| 19 | 37570 | 18785.0 | 1165.54 | 582.8 | The neighbor-joining method: a new method for reconstructing phylogenetic trees. | N Saitou, M Nei | Mol Biol Evol | 1987 | 3447015 | Yes |
| 20 | 18500 | 18500.0 | 0.0 | 0.0 | Tissue sulfhydryl groups. | G L Ellman | Arch Biochem Biophys | 1959 | 13650640 | Yes |
| 21 | 53236 | 17745.3 | 0.0 | 0.0 | Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. | H Towbin, T Staehelin, J Gordon | Proc Natl Acad Sci U S A | 1979 | 388439 | Yes |
| 22 | 35217 | 17608.5 | 1210.73 | 605.4 | Hallmarks of cancer: the next generation. | Douglas Hanahan, Robert A Weinberg | Cell | 2011 | 21376230 | No |
| 23 | 33804 | 16902.0 | 1629.02 | 814.5 | Statistical methods for assessing agreement between two methods of clinical measurement. | J M Bland, D G Altman | Lancet | 1986 | 2868172 | Yes |
| 24 | 16805 | 16805.0 | 0.0 | 0.0 | Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. | B J Davis | Ann N Y Acad Sci | 1964 | 14240539 | Yes |
| 25 | 16334 | 16334.0 | 421.77 | 421.8 | Atherosclerosis--an inflammatory disease. | R Ross | N Engl J Med | 1999 | 9887164 | No |
| 26 | 16205 | 16205.0 | 0.0 | 0.0 | High resolution two-dimensional electrophoresis of proteins. | P H O'Farrell | J Biol Chem | 1975 | 236308 | Yes |
| 27 | 15908 | 15908.0 | 0.0 | 0.0 | A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. | K Burton | Biochem J | 1956 | 13293190 | Yes |
| 28 | 15831 | 15831.0 | 590.89 | 590.9 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. | M Kimura | J Mol Evol | 1980 | 7463489 | Yes |
| 29 | 30999 | 15499.5 | 0.0 | 0.0 | A rapid method of total lipid extraction and purification. | E G Bligh, W J Dyer | Can J Biochem Physiol | 1959 | 13671378 | Yes |
| 30 | 30247 | 15123.5 | 0.0 | 0.0 | The measurement of observer agreement for categorical data. | J R Landis, G G Koch | Biometrics | 1977 | 843571 | Yes |
| 31 | 43880 | 14626.7 | 1264.44 | 421.5 | CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. | J D Thompson, D G Higgins, T J Gibson | Nucleic Acids Res | 1994 | 7984417 | Yes |
| 32 | 14255 | 14255.0 | 418.75 | 418.8 | Projector augmented-wave method. | Blöchl | Phys Rev B Condens Matter | 1994 | 9976227 | Yes |
| 33 | 14069 | 14069.0 | 378.1 | 378.1 | MicroRNAs: target recognition and regulatory functions. | David P Bartel | Cell | 2009 | 19167326 | No |
| 34 | 40768 | 13589.3 | 0.0 | 0.0 | A simple method for the isolation and purification of total lipides from animal tissues. | J Folch, M Lees, G H Sloane Stanley | J Biol Chem | 1957 | 13428781 | Yes |
| 35 | 13511 | 13511.0 | 568.21 | 568.2 | A power primer. | J Cohen | Psychol Bull | 1992 | 19565683 | Yes |
| 36 | 26708 | 13354.0 | 1026.81 | 513.4 | Meta-analysis in clinical trials. | R DerSimonian, N Laird | Control Clin Trials | 1986 | 3802833 | Yes |
| 37 | 26374 | 13187.0 | 1089.29 | 544.6 | The hospital anxiety and depression scale. | A S Zigmond, R P Snaith | Acta Psychiatr Scand | 1983 | 6880820 | Yes |
| 38 | 13027 | 13027.0 | 646.25 | 646.2 | RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. | Alexandros Stamatakis | Bioinformatics | 2014 | 24451623 | Yes |
| 39 | 12625 | 12625.0 | 499.46 | 499.5 | Catalase in vitro. | H Aebi | Methods Enzymol | 1984 | 6727660 | Yes |
| 40 | 12619 | 12619.0 | 0.0 | 0.0 | Phosphorus assay in column chromatography. | G R Bartlett | J Biol Chem | 1959 | 13641241 | Yes |
| 41 | 36808 | 12269.3 | 1134.92 | 378.3 | Generalized Gradient Approximation Made Simple. | Perdew, Burke, Ernzerhof | Phys Rev Lett | 1996 | 10062328 | Yes |
| 42 | 57334 | 11466.8 | 1657.88 | 331.6 | Basic local alignment search tool. | S F Altschul, W Gish, W Miller, E W Myers, D J Lipman | J Mol Biol | 1990 | 2231712 | Yes |
| 43 | 22874 | 11437.0 | 622.9 | 311.4 | Fast and accurate short read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2009 | 19451168 | Yes |
| 44 | 22492 | 11246.0 | 946.12 | 473.1 | The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. | J E Ware, C D Sherbourne | Med Care | 1992 | 1593914 | Yes |
| 45 | 33611 | 11203.7 | 1221.19 | 407.1 | Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. | Lee, Yang, Parr | Phys Rev B Condens Matter | 1988 | 9944570 | Yes |
| 46 | 22267 | 11133.5 | 483.53 | 241.8 | Coot: model-building tools for molecular graphics. | Paul Emsley, Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2004 | 15572765 | Yes |
| 47 | 21721 | 10860.5 | 770.8 | 385.4 | Fast gapped-read alignment with Bowtie 2. | Ben Langmead, Steven L Salzberg | Nat Methods | 2012 | 22388286 | Yes |
| 48 | 21563 | 10781.5 | 560.14 | 280.1 | A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. | A P Feinberg, B Vogelstein | Anal Biochem | 1983 | 6312838 | Yes |
| 49 | 10726 | 10726.0 | 360.67 | 360.7 | Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). | J F Kurtzke | Neurology | 1983 | 6685237 | Yes |
| 50 | 10644 | 10644.0 | 377.39 | 377.4 | Search and clustering orders of magnitude faster than BLAST. | Robert C Edgar | Bioinformatics | 2010 | 20709691 | Yes |
| 51 | 10457 | 10457.0 | 0.0 | 0.0 | The genetics of Caenorhabditis elegans. | S Brenner | Genetics | 1974 | 4366476 | Yes |
| 52 | 20690 | 10345.0 | 462.35 | 231.2 | [20] Processing of X-ray diffraction data collected in oscillation mode. | Zbyszek Otwinowski, Wladek Minor | Methods Enzymol | 1997 | 27799103 | Yes |
| 53 | 10334 | 10334.0 | 0.0 | 0.0 | Improvements in epoxy resin embedding methods. | J H Luft | J Biophys Biochem Cytol | 1961 | 13764136 | Yes |
| 54 | 10321 | 10321.0 | 317.09 | 317.1 | The Psychophysics Toolbox. | D H Brainard | Spat Vis | 1997 | 9176952 | Yes |
| 55 | 10275 | 10275.0 | 287.88 | 287.9 | Xds. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124692 | Yes |
| 56 | 10196 | 10196.0 | 383.62 | 383.6 | Structure validation in chemical crystallography. | Anthony L Spek | Acta Crystallogr D Biol Crystallogr | 2009 | 19171970 | Yes |
| 57 | 10003 | 10003.0 | 0.0 | 0.0 | Self-efficacy: toward a unifying theory of behavioral change. | A Bandura | Psychol Rev | 1977 | 847061 | Yes |
| 58 | 9987 | 9987.0 | 625.3 | 625.3 | Crystal structure refinement with SHELXL. | George M Sheldrick | Acta Crystallogr C Struct Chem | 2015 | 25567568 | Yes |
| 59 | 19785 | 9892.5 | 0.0 | 0.0 | The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. | K Weber, M Osborn | J Biol Chem | 1969 | 5806584 | Yes |
| 60 | 9619 | 9619.0 | 376.32 | 376.3 | A new method for measuring daytime sleepiness: the Epworth sleepiness scale. | M W Johns | Sleep | 1991 | 1798888 | Yes |
| 61 | 18890 | 9445.0 | 529.51 | 264.8 | Quantifying heterogeneity in a meta-analysis. | Julian P T Higgins, Simon G Thompson | Stat Med | 2002 | 12111919 | Yes |
| 62 | 9438 | 9438.0 | 321.31 | 321.3 | Banting lecture 1988. Role of insulin resistance in human disease. | G M Reaven | Diabetes | 1988 | 3056758 | No |
| 63 | 18590 | 9295.0 | 536.04 | 268.0 | Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. | Kresse, Furthmüller | Phys Rev B Condens Matter | 1996 | 9984901 | Yes |
| 64 | 9255 | 9255.0 | 269.55 | 269.6 | Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. | P S Thomas | Proc Natl Acad Sci U S A | 1980 | 6159641 | Yes |
| 65 | 18491 | 9245.5 | 830.42 | 415.2 | The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. | R M Baron, D A Kenny | J Pers Soc Psychol | 1986 | 3806354 | Yes |
| 66 | 18340 | 9170.0 | 482.1 | 241.1 | A simple method for displaying the hydropathic character of a protein. | J Kyte, R F Doolittle | J Mol Biol | 1982 | 7108955 | Yes |
| 67 | 9156 | 9156.0 | 243.46 | 243.5 | Studies on transformation of Escherichia coli with plasmids. | D Hanahan | J Mol Biol | 1983 | 6345791 | Yes |
| 68 | 9092 | 9092.0 | 260.6 | 260.6 | The pathogenesis of atherosclerosis: a perspective for the 1990s. | R Ross | Nature | 1993 | 8479518 | No |
| 69 | 8979 | 8979.0 | 235.92 | 235.9 | Integrins: versatility, modulation, and signaling in cell adhesion. | R O Hynes | Cell | 1992 | 1555235 | No |
| 70 | 8825 | 8825.0 | 191.92 | 191.9 | Mfold web server for nucleic acid folding and hybridization prediction. | Michael Zuker | Nucleic Acids Res | 2003 | 12824337 | Yes |
| 71 | 8785 | 8785.0 | 251.31 | 251.3 | Evolutionary trees from DNA sequences: a maximum likelihood approach. | J Felsenstein | J Mol Evol | 1981 | 7288891 | Yes |
| 72 | 8743 | 8743.0 | 0.0 | 0.0 | On the origin of cancer cells. | O Warburg | Science | 1956 | 13298683 | Yes |
| 73 | 8671 | 8671.0 | 235.57 | 235.6 | RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. | Alexandros Stamatakis | Bioinformatics | 2006 | 16928733 | Yes |
| 74 | 25898 | 8632.7 | 689.13 | 229.7 | VMD: visual molecular dynamics. | W Humphrey, A Dalke, K Schulten | J Mol Graph | 1996 | 8744570 | Yes |
| 75 | 8569 | 8569.0 | 263.34 | 263.3 | Vitamin D deficiency. | Michael F Holick | N Engl J Med | 2007 | 17634462 | No |
| 76 | 33872 | 8468.0 | 1009.43 | 252.4 | Measuring inconsistency in meta-analyses. | Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman | BMJ | 2003 | 12958120 | No |
| 77 | 25370 | 8456.7 | 1076.0 | 358.7 | Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. | Michael I Love, Wolfgang Huber, Simon Anders | Genome Biol | 2014 | 25516281 | Yes |
| 78 | 16803 | 8401.5 | 364.54 | 182.3 | The hallmarks of cancer. | D Hanahan, R A Weinberg | Cell | 2000 | 10647931 | No |
| 79 | 33430 | 8357.5 | 1398.85 | 349.7 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | PLoS Med | 2009 | 19621072 | No |
| 80 | 8319 | 8319.0 | 175.6 | 175.6 | Linear models and empirical bayes methods for assessing differential expression in microarray experiments. | Gordon K Smyth | Stat Appl Genet Mol Biol | 2004 | 16646809 | Yes |
| 81 | 8216 | 8216.0 | 366.12 | 366.1 | Psychophysical bases of perceived exertion. | G A Borg | Med Sci Sports Exerc | 1982 | 7154893 | Yes |
| 82 | 8058 | 8058.0 | 230.36 | 230.4 | Semiempirical GGA-type density functional constructed with a long-range dispersion correction. | Stefan Grimme | J Comput Chem | 2006 | 16955487 | Yes |
| 83 | 8012 | 8012.0 | 175.8 | 175.8 | The functions of animal microRNAs. | Victor Ambros | Nature | 2004 | 15372042 | No |
| 84 | 8008 | 8008.0 | 0.0 | 0.0 | Solvent content of protein crystals. | B W Matthews | J Mol Biol | 1968 | 5700707 | Yes |
| 85 | 31217 | 7804.2 | 1192.76 | 298.2 | A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. | M E Charlson, P Pompei, K L Ales, C R MacKenzie | J Chronic Dis | 1987 | 3558716 | Yes |
| 86 | 7798 | 7798.0 | 0.0 | 0.0 | Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. | D I Arnon | Plant Physiol | 1949 | 16654194 | Yes |
| 87 | 7788 | 7788.0 | 297.35 | 297.4 | Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. | Andreas Stang | Eur J Epidemiol | 2010 | 20652370 | Yes |
| 88 | 7786 | 7786.0 | 218.55 | 218.6 | The role of protein kinase C in cell surface signal transduction and tumour promotion. | Y Nishizuka | Nature | 1984 | 6232463 | No |
| 89 | 7777 | 7777.0 | 209.16 | 209.2 | Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. | M C Hochberg | Arthritis Rheum | 1997 | 9324032 | Yes |
| 90 | 7769 | 7769.0 | 218.56 | 218.6 | "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. | W N Burnette | Anal Biochem | 1981 | 6266278 | Yes |
| 91 | 23175 | 7725.0 | 870.24 | 290.1 | NIH Image to ImageJ: 25 years of image analysis. | Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri | Nat Methods | 2012 | 22930834 | No |
| 92 | 7717 | 7717.0 | 0.0 | 0.0 | A simplification of the protein assay method of Lowry et al. which is more generally applicable. | G L Peterson | Anal Biochem | 1977 | 603028 | Yes |
| 93 | 15429 | 7714.5 | 358.51 | 179.3 | Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. | Kazutoshi Takahashi, Shinya Yamanaka | Cell | 2006 | 16904174 | Yes |
| 94 | 23111 | 7703.7 | 636.85 | 212.3 | Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nat Protoc | 2009 | 19131956 | Yes |
| 95 | 7578 | 7578.0 | 0.0 | 0.0 | Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. | J R Vane | Nat New Biol | 1971 | 5284360 | Yes |
| 96 | 7448 | 7448.0 | 244.26 | 244.3 | The blockade of immune checkpoints in cancer immunotherapy. | Drew M Pardoll | Nat Rev Cancer | 2012 | 22437870 | No |
| 97 | 29399 | 7349.8 | 974.84 | 243.7 | Bias in meta-analysis detected by a simple, graphical test. | M Egger, G Davey Smith, M Schneider, C Minder | BMJ | 1997 | 9310563 | Yes |
| 98 | 14598 | 7299.0 | 408.64 | 204.3 | Analyzing real-time PCR data by the comparative C(T) method. | Thomas D Schmittgen, Kenneth J Livak | Nat Protoc | 2008 | 18546601 | Yes |
| 99 | 7273 | 7273.0 | 0.0 | 0.0 | A low-viscosity epoxy resin embedding medium for electron microscopy. | A R Spurr | J Ultrastruct Res | 1969 | 4887011 | Yes |
| 100 | 14546 | 7273.0 | 637.54 | 318.8 | MAFFT multiple sequence alignment software version 7: improvements in performance and usability. | Kazutaka Katoh, Daron M Standley | Mol Biol Evol | 2013 | 23329690 | Yes |
| 101 | 7258 | 7258.0 | 0.0 | 0.0 | Tumor angiogenesis: therapeutic implications. | J Folkman | N Engl J Med | 1971 | 4938153 | No |
| 102 | 14508 | 7254.0 | 364.16 | 182.1 | MrBayes 3: Bayesian phylogenetic inference under mixed models. | Fredrik Ronquist, John P Huelsenbeck | Bioinformatics | 2003 | 12912839 | Yes |
| 103 | 21736 | 7245.3 | 990.84 | 330.3 | Trimmomatic: a flexible trimmer for Illumina sequence data. | Anthony M Bolger, Marc Lohse, Bjoern Usadel | Bioinformatics | 2014 | 24695404 | Yes |
| 104 | 7233 | 7233.0 | 197.43 | 197.4 | Canonical dynamics: Equilibrium phase-space distributions. | Hoover | Phys Rev A Gen Phys | 1985 | 9895674 | Yes |
| 105 | 7192 | 7192.0 | 329.57 | 329.6 | Investigation of the freely available easy-to-use software 'EZR' for medical statistics. | Y Kanda | Bone Marrow Transplant | 2013 | 23208313 | Yes |
| 106 | 7182 | 7182.0 | 216.76 | 216.8 | AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. | R W Cox | Comput Biomed Res | 1996 | 8812068 | Yes |
| 107 | 7170 | 7170.0 | 182.59 | 182.6 | PAML 4: phylogenetic analysis by maximum likelihood. | Ziheng Yang | Mol Biol Evol | 2007 | 17483113 | Yes |
| 108 | 14138 | 7069.0 | 312.52 | 156.3 | KEGG: kyoto encyclopedia of genes and genomes. | M Kanehisa, S Goto | Nucleic Acids Res | 2000 | 10592173 | Yes |
| 109 | 7041 | 7041.0 | 239.58 | 239.6 | Density-functional approximation for the correlation energy of the inhomogeneous electron gas. | Perdew | Phys Rev B Condens Matter | 1986 | 9938299 | Yes |
| 110 | 49147 | 7021.0 | 1290.91 | 184.4 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. | S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J Lipman | Nucleic Acids Res | 1997 | 9254694 | No |
| 111 | 7014 | 7014.0 | 193.09 | 193.1 | TreeView: an application to display phylogenetic trees on personal computers. | R D Page | Comput Appl Biosci | 1996 | 8902363 | Yes |
| 112 | 21041 | 7013.7 | 0.0 | 0.0 | Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. | W T Friedewald, R I Levy, D S Fredrickson | Clin Chem | 1972 | 4337382 | Yes |
| 113 | 6954 | 6954.0 | 328.34 | 328.3 | Comparative fit indexes in structural models. | P M Bentler | Psychol Bull | 1990 | 2320703 | Yes |
| 114 | 6947 | 6947.0 | 0.0 | 0.0 | Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. | A Böyum | Scand J Clin Lab Invest Suppl | 1968 | 4179068 | Yes |
| 115 | 6947 | 6947.0 | 157.32 | 157.3 | Chromatin modifications and their function. | Tony Kouzarides | Cell | 2007 | 17320507 | No |
| 116 | 6900 | 6900.0 | 186.55 | 186.6 | Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. | F Tajima | Genetics | 1989 | 2513255 | Yes |
| 117 | 13594 | 6797.0 | 312.77 | 156.4 | Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. | S J Clough, A F Bent | Plant J | 1998 | 10069079 | Yes |
| 118 | 6795 | 6795.0 | 184.76 | 184.8 | The steroid and thyroid hormone receptor superfamily. | R M Evans | Science | 1988 | 3283939 | No |
| 119 | 13557 | 6778.5 | 0.0 | 0.0 | Continuous cultures of fused cells secreting antibody of predefined specificity. | G Köhler, C Milstein | Nature | 1975 | 1172191 | Yes |
| 120 | 13519 | 6759.5 | 289.21 | 144.6 | Processing of X-ray diffraction data collected in oscillation mode. | Z Otwinowski, W Minor | Methods Enzymol | 1997 | 27754618 | Yes |
| 121 | 6750 | 6750.0 | 188.01 | 188.0 | Apoptosis: a review of programmed cell death. | Susan Elmore | Toxicol Pathol | 2007 | 17562483 | No |
| 122 | 6702 | 6702.0 | 171.49 | 171.5 | Fast robust automated brain extraction. | Stephen M Smith | Hum Brain Mapp | 2002 | 12391568 | No |
| 123 | 6686 | 6686.0 | 0.0 | 0.0 | The thiobarbituric acid assay of sialic acids. | L Warren | J Biol Chem | 1959 | 13672998 | Yes |
| 124 | 6683 | 6683.0 | 0.0 | 0.0 | The assessment of anxiety states by rating. | M Hamilton | Br J Med Psychol | 1959 | 13638508 | Yes |
| 125 | 19681 | 6560.3 | 560.28 | 186.8 | A new generation of Ca2+ indicators with greatly improved fluorescence properties. | G Grynkiewicz, M Poenie, R Y Tsien | J Biol Chem | 1985 | 3838314 | Yes |
| 126 | 19564 | 6521.3 | 1373.2 | 457.7 | MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. | Sudhir Kumar, Glen Stecher, Koichiro Tamura | Mol Biol Evol | 2016 | 27004904 | Yes |
| 127 | 6519 | 6519.0 | 172.66 | 172.7 | Adhesion receptors of the immune system. | T A Springer | Nature | 1990 | 1974032 | No |
| 128 | 6477 | 6477.0 | 199.29 | 199.3 | The VideoToolbox software for visual psychophysics: transforming numbers into movies. | D G Pelli | Spat Vis | 1997 | 9176953 | Yes |
| 129 | 6431 | 6431.0 | 169.46 | 169.5 | Angiogenesis in cancer, vascular, rheumatoid and other disease. | J Folkman | Nat Med | 1995 | 7584949 | No |
| 130 | 12805 | 6402.5 | 0.0 | 0.0 | Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. | Y Cheng, W H Prusoff | Biochem Pharmacol | 1973 | 4202581 | Yes |
| 131 | 38283 | 6380.5 | 3699.82 | 616.6 | Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. | Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal | CA Cancer J Clin | 2018 | 30207593 | Yes |
| 132 | 6366 | 6366.0 | 130.35 | 130.3 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel | Proc Natl Acad Sci U S A | 1985 | 3881765 | Yes |
| 133 | 12708 | 6354.0 | 0.0 | 0.0 | Statistical aspects of the analysis of data from retrospective studies of disease. | N Mantel, W Haenszel | J Natl Cancer Inst | 1959 | 13655060 | Yes |
| 134 | 6295 | 6295.0 | 208.88 | 208.9 | Ethical guidelines for investigations of experimental pain in conscious animals. | Manfred Zimmermann | Pain | 1983 | 6877845 | No |
| 135 | 6246 | 6246.0 | 204.82 | 204.8 | The Clinical Dementia Rating (CDR): current version and scoring rules. | J C Morris | Neurology | 1993 | 8232972 | Yes |
| 136 | 6214 | 6214.0 | 135.67 | 135.7 | p53, the cellular gatekeeper for growth and division. | A J Levine | Cell | 1997 | 9039259 | No |
| 137 | 12207 | 6103.5 | 0.0 | 0.0 | A rapid alkaline extraction procedure for screening recombinant plasmid DNA. | H C Birnboim, J Doly | Nucleic Acids Res | 1979 | 388356 | Yes |
| 138 | 6072 | 6072.0 | 124.89 | 124.9 | Integrins: bidirectional, allosteric signaling machines. | Richard O Hynes | Cell | 2002 | 12297042 | No |
| 139 | 12097 | 6048.5 | 0.0 | 0.0 | Prediction of creatinine clearance from serum creatinine. | D W Cockcroft, M H Gault | Nephron | 1976 | 1244564 | Yes |
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| 3503 | 3060 | 1020.0 | 74.91 | 25.0 | Nitric oxide and macrophage function. | J MacMicking, Q W Xie, C Nathan | Annu Rev Immunol | 1997 | 9143691 | No |
| 3504 | 1020 | 1020.0 | 26.7 | 26.7 | Formation and function of the myofibroblast during tissue repair. | Boris Hinz | J Invest Dermatol | 2007 | 17299435 | No |
| 3505 | 2039 | 1019.5 | 91.09 | 45.5 | Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. | Ian Janssen, Allana G Leblanc | Int J Behav Nutr Phys Act | 2010 | 20459784 | Yes |
| 3506 | 1019 | 1019.0 | 38.92 | 38.9 | The ovariectomized rat model of postmenopausal bone loss. | D N Kalu | Bone Miner | 1991 | 1773131 | No |
| 3507 | 1019 | 1019.0 | 0.0 | 0.0 | Presidental address. Neuropathological aspects of brain edema. | I Klatzo | J Neuropathol Exp Neurol | 1967 | 5336776 | No |
| 3508 | 1019 | 1019.0 | 53.47 | 53.5 | Osseointegration and its experimental background. | P I Brånemark | J Prosthet Dent | 1983 | 6352924 | No |
| 3509 | 1019 | 1019.0 | 0.0 | 0.0 | Simplified Myeloperoxidase Stain Using Benzidine Dihydrochloride. | L S Kaplow | Blood | 1965 | 14332483 | Yes |
| 3510 | 1018 | 1018.0 | 17.62 | 17.6 | Functional inactivation of genes by dominant negative mutations. | I Herskowitz | Nature | 1987 | 2442619 | No |
| 3511 | 2036 | 1018.0 | 80.52 | 40.3 | Glutathione reductase. | I Carlberg, B Mannervik | Methods Enzymol | 1985 | 3003504 | Yes |
| 3512 | 1018 | 1018.0 | 21.22 | 21.2 | Resolution of phase ambiguity in macromolecular crystallography. | B C Wang | Methods Enzymol | 1985 | 4079800 | Yes |
| 3513 | 1018 | 1018.0 | 32.0 | 32.0 | Prevention of drug access to bacterial targets: permeability barriers and active efflux. | H Nikaido | Science | 1994 | 8153625 | No |
| 3514 | 1018 | 1018.0 | 19.88 | 19.9 | Initiation of translation in prokaryotes and eukaryotes. | M Kozak | Gene | 1999 | 10395892 | No |
| 3515 | 1018 | 1018.0 | 28.06 | 28.1 | Invited review: Aging and sarcopenia. | Timothy J Doherty | J Appl Physiol (1985) | 2003 | 12970377 | No |
| 3516 | 2035 | 1017.5 | 56.54 | 28.3 | Mechanisms of biofilm resistance to antimicrobial agents. | T F Mah, G A O'Toole | Trends Microbiol | 2001 | 11166241 | No |
| 3517 | 1017 | 1017.0 | 32.44 | 32.4 | Food reward: brain substrates of wanting and liking. | K C Berridge | Neurosci Biobehav Rev | 1996 | 8622814 | No |
| 3518 | 1017 | 1017.0 | 28.89 | 28.9 | Ion suppression in mass spectrometry. | Thomas M Annesley | Clin Chem | 2003 | 12816898 | No |
| 3519 | 4067 | 1016.8 | 137.13 | 34.3 | Epidemiology and causes of preterm birth. | Robert L Goldenberg, Jennifer F Culhane, Jay D Iams, Roberto Romero | Lancet | 2008 | 18177778 | No |
| 3520 | 10166 | 1016.6 | 271.19 | 27.1 | Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. | M Dominici, K Le Blanc, I Mueller, I Slaper-Cortenbach, Fc Marini, Ds Krause, Rj Deans, A Keating, Dj Prockop, Em Horwitz | Cytotherapy | 2006 | 16923606 | Yes |
| 3521 | 2033 | 1016.5 | 0.0 | 0.0 | Fine structural localization of a blood-brain barrier to exogenous peroxidase. | T S Reese, M J Karnovsky | J Cell Biol | 1967 | 6033532 | Yes |
| 3522 | 2033 | 1016.5 | 81.72 | 40.9 | Statistical methods for assessing measurement error (reliability) in variables relevant to sports medicine. | G Atkinson, A M Nevill | Sports Med | 1998 | 9820922 | No |
| 3523 | 2033 | 1016.5 | 47.33 | 23.7 | Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. | Daniel J Hicklin, Lee M Ellis | J Clin Oncol | 2005 | 15585754 | No |
| 3524 | 3049 | 1016.3 | 63.0 | 21.0 | The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. | W H Landschulz, P F Johnson, S L McKnight | Science | 1988 | 3289117 | Yes |
| 3525 | 1016 | 1016.0 | 35.52 | 35.5 | Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance. | M D Majewska | Prog Neurobiol | 1992 | 1349441 | No |
| 3526 | 1016 | 1016.0 | 25.33 | 25.3 | DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. | J F Ward | Prog Nucleic Acid Res Mol Biol | 1988 | 3065826 | No |
| 3527 | 1016 | 1016.0 | 25.94 | 25.9 | Molten globule and protein folding. | O B Ptitsyn | Adv Protein Chem | 1995 | 8561052 | No |
| 3528 | 1016 | 1016.0 | 24.16 | 24.2 | BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data. | O Gascuel | Mol Biol Evol | 1997 | 9254330 | Yes |
| 3529 | 1016 | 1016.0 | 0.0 | 0.0 | Fluorescent antibody methods. | A H Coons | Gen Cytochem Methods | 1958 | 13574437 | Yes |
| 3530 | 2032 | 1016.0 | 51.07 | 25.5 | Toxoplasmosis. | J G Montoya, O Liesenfeld | Lancet | 2004 | 15194258 | No |
| 3531 | 1016 | 1016.0 | 28.82 | 28.8 | Production and scavenging of reactive oxygen species in chloroplasts and their functions. | Kozi Asada | Plant Physiol | 2006 | 16760493 | Yes |
| 3532 | 1016 | 1016.0 | 201.37 | 201.4 | Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. | Jonas F Ludvigsson | Acta Paediatr | 2020 | 32202343 | Yes |
| 3533 | 2031 | 1015.5 | 54.52 | 27.3 | Compilation and analysis of Escherichia coli promoter DNA sequences. | D K Hawley, W R McClure | Nucleic Acids Res | 1983 | 6344016 | No |
| 3534 | 6093 | 1015.5 | 137.71 | 23.0 | Obesity is associated with macrophage accumulation in adipose tissue. | Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W Ferrante | J Clin Invest | 2003 | 14679176 | Yes |
| 3535 | 1015 | 1015.0 | 29.03 | 29.0 | Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease. | W J Welch | Physiol Rev | 1992 | 1438579 | No |
| 3536 | 1015 | 1015.0 | 22.16 | 22.2 | Potential metal-binding domains in nucleic acid binding proteins. | J M Berg | Science | 1986 | 2421409 | Yes |
| 3537 | 1015 | 1015.0 | 0.0 | 0.0 | Vagal sensory receptors and their reflex effects. | A S Paintal | Physiol Rev | 1973 | 4568412 | No |
| 3538 | 2030 | 1015.0 | 40.51 | 20.3 | Cellular functions regulated by Src family kinases. | S M Thomas, J S Brugge | Annu Rev Cell Dev Biol | 1997 | 9442882 | No |
| 3539 | 4060 | 1015.0 | 100.42 | 25.1 | The epidemiology of sepsis in the United States from 1979 through 2000. | Greg S Martin, David M Mannino, Stephanie Eaton, Marc Moss | N Engl J Med | 2003 | 12700374 | Yes |
| 3540 | 1015 | 1015.0 | 0.0 | 0.0 | Regional blood flow by fractional distribution of indicators. | L A Sapirstein | Am J Physiol | 1958 | 13521003 | Yes |
| 3541 | 1015 | 1015.0 | 31.02 | 31.0 | Rethinking schizophrenia. | Thomas R Insel | Nature | 2010 | 21068826 | No |
| 3542 | 1015 | 1015.0 | 33.31 | 33.3 | Isolation By Distance In Equilibrium And Non-Equilibrium Populations. | Montgomery Slatkin | Evolution | 1993 | 28568097 | Yes |
| 3543 | 6089 | 1014.8 | 161.22 | 26.9 | The capsaicin receptor: a heat-activated ion channel in the pain pathway. | M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D Julius | Nature | 1997 | 9349813 | Yes |
| 3544 | 2028 | 1014.0 | 0.0 | 0.0 | Comparative aspects of the brain growth spurt. | J Dobbing, J Sands | Early Hum Dev | 1979 | 118862 | Yes |
| 3545 | 1014 | 1014.0 | 31.7 | 31.7 | Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion. | E Falk | Circulation | 1985 | 3971539 | Yes |
| 3546 | 1014 | 1014.0 | 37.85 | 37.9 | Cellular mechanisms of muscle fatigue. | R H Fitts | Physiol Rev | 1994 | 8295935 | No |
| 3547 | 1014 | 1014.0 | 25.54 | 25.5 | Biological effects of resveratrol. | L Frémont | Life Sci | 2000 | 10680575 | No |
| 3548 | 1014 | 1014.0 | 40.87 | 40.9 | The evolving concept of health literacy. | Don Nutbeam | Soc Sci Med | 2008 | 18952344 | Yes |
| 3549 | 2028 | 1014.0 | 50.7 | 25.4 | Establishing, maintaining and modifying DNA methylation patterns in plants and animals. | Julie A Law, Steven E Jacobsen | Nat Rev Genet | 2010 | 20142834 | No |
| 3550 | 1014 | 1014.0 | 29.77 | 29.8 | AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. | D Grahame Hardie | Genes Dev | 2011 | 21937710 | No |
| 3551 | 2026 | 1013.0 | 0.0 | 0.0 | The period of susceptibility to the physiological effects of unilateral eye closure in kittens. | D H Hubel, T N Wiesel | J Physiol | 1970 | 5498493 | Yes |
| 3552 | 1013 | 1013.0 | 27.92 | 27.9 | Core affect and the psychological construction of emotion. | James A Russell | Psychol Rev | 2003 | 12529060 | No |
| 3553 | 2026 | 1013.0 | 52.71 | 26.4 | Adipocytokines: mediators linking adipose tissue, inflammation and immunity. | Herbert Tilg, Alexander R Moschen | Nat Rev Immunol | 2006 | 16998510 | No |
| 3554 | 1013 | 1013.0 | 0.0 | 0.0 | Histological and histochemical uses of periodic acid. | J F A McMANUS | Stain Technol | 1948 | 18867618 | Yes |
| 3555 | 2025 | 1012.5 | 0.0 | 0.0 | Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. | S Ohkuma, B Poole | Proc Natl Acad Sci U S A | 1978 | 28524 | Yes |
| 3556 | 6073 | 1012.2 | 188.76 | 31.5 | Prevalence of overweight and obesity in the United States, 1999-2004. | Cynthia L Ogden, Margaret D Carroll, Lester R Curtin, Margaret A McDowell, Carolyn J Tabak, Katherine M Flegal | JAMA | 2006 | 16595758 | Yes |
| 3557 | 1012 | 1012.0 | 41.42 | 41.4 | Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. | R J Cousins | Physiol Rev | 1985 | 3885271 | No |
| 3558 | 1012 | 1012.0 | 26.2 | 26.2 | Skeletal complications of malignancy. | R E Coleman | Cancer | 1997 | 9362426 | No |
| 3559 | 1012 | 1012.0 | 27.56 | 27.6 | Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. | Michael F Holick | Am J Clin Nutr | 2004 | 14985208 | No |
| 3560 | 1012 | 1012.0 | 25.23 | 25.2 | Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. | Thomas A Wynn | J Clin Invest | 2007 | 17332879 | No |
| 3561 | 1012 | 1012.0 | 25.4 | 25.4 | Transcriptional paradigms in mammalian mitochondrial biogenesis and function. | Richard C Scarpulla | Physiol Rev | 2008 | 18391175 | No |
| 3562 | 1012 | 1012.0 | 219.76 | 219.8 | A Review of Coronavirus Disease-2019 (COVID-19). | Tanu Singhal | Indian J Pediatr | 2020 | 32166607 | No |
| 3563 | 3034 | 1011.3 | 87.83 | 29.3 | Matrix metalloproteinases: regulators of the tumor microenvironment. | Kai Kessenbrock, Vicki Plaks, Zena Werb | Cell | 2010 | 20371345 | No |
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