Unicorn Papers
Top ‱ cited papers from PUBMED
Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authorsCurrently, the list contains 3535 papers with ECcit ≥ 1007.3
‱ - permyriad,
, literally meaning "for (every) myriad (ten thousand)"
Volume 20, April 2022
| No. | Citations | ECcit | RCR | ECRCR | Title | Authors | Journal | Year | PMID | Article(?) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 222172 | 222172.0 | 0.0 | 0.0 | Cleavage of structural proteins during the assembly of the head of bacteriophage T4. | U K Laemmli | Nature | 1970 | 5432063 | Yes |
| 2 | 169204 | 169204.0 | 0.0 | 0.0 | A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. | M M Bradford | Anal Biochem | 1976 | 942051 | Yes |
| 3 | 284496 | 71124.0 | 0.0 | 0.0 | Protein measurement with the Folin phenol reagent. | O H Lowry, N J Rosebrough, A L Farr, R J Randall | J Biol Chem | 1951 | 14907713 | Yes |
| 4 | 100891 | 50445.5 | 2583.86 | 1291.9 | Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. | K J Livak, T D Schmittgen | Methods | 2001 | 11846609 | Yes |
| 5 | 43357 | 43357.0 | 1436.22 | 1436.2 | A short history of SHELX. | George M Sheldrick | Acta Crystallogr A | 2008 | 18156677 | Yes |
| 6 | 34193 | 34193.0 | 1108.42 | 1108.4 | Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. | T Mosmann | J Immunol Methods | 1983 | 6606682 | Yes |
| 7 | 65123 | 32561.5 | 1971.75 | 985.9 | Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. | P Chomczynski, N Sacchi | Anal Biochem | 1987 | 2440339 | Yes |
| 8 | 30196 | 30196.0 | 0.0 | 0.0 | Detection of specific sequences among DNA fragments separated by gel electrophoresis. | E M Southern | J Mol Biol | 1975 | 1195397 | Yes |
| 9 | 25851 | 25851.0 | 0.0 | 0.0 | The assessment and analysis of handedness: the Edinburgh inventory. | R C Oldfield | Neuropsychologia | 1971 | 5146491 | Yes |
| 10 | 25519 | 25519.0 | 585.84 | 585.8 | MicroRNAs: genomics, biogenesis, mechanism, and function. | David P Bartel | Cell | 2004 | 14744438 | No |
| 11 | 23965 | 23965.0 | 0.0 | 0.0 | A rating scale for depression. | M Hamilton | J Neurol Neurosurg Psychiatry | 1960 | 14399272 | Yes |
| 12 | 22794 | 22794.0 | 715.5 | 715.5 | Confidence Limits On Phylogenies: An Approach Using The Bootstrap. | Joseph Felsenstein | Evolution | 1985 | 28561359 | Yes |
| 13 | 22444 | 22444.0 | 553.07 | 553.1 | MUSCLE: multiple sequence alignment with high accuracy and high throughput. | Robert C Edgar | Nucleic Acids Res | 2004 | 15034147 | Yes |
| 14 | 22009 | 22009.0 | 520.81 | 520.8 | A new mathematical model for relative quantification in real-time RT-PCR. | M W Pfaffl | Nucleic Acids Res | 2001 | 11328886 | Yes |
| 15 | 65478 | 21826.0 | 0.0 | 0.0 | DNA sequencing with chain-terminating inhibitors. | F Sanger, S Nicklen, A R Coulson | Proc Natl Acad Sci U S A | 1977 | 271968 | Yes |
| 16 | 61372 | 20457.3 | 0.0 | 0.0 | "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. | M F Folstein, S E Folstein, P R McHugh | J Psychiatr Res | 1975 | 1202204 | Yes |
| 17 | 20011 | 20011.0 | 0.0 | 0.0 | The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. | E S Reynolds | J Cell Biol | 1963 | 13986422 | Yes |
| 18 | 18778 | 18778.0 | 665.02 | 665.0 | Density-functional exchange-energy approximation with correct asymptotic behavior. | Becke | Phys Rev A Gen Phys | 1988 | 9900728 | Yes |
| 19 | 37330 | 18665.0 | 1158.39 | 579.2 | The neighbor-joining method: a new method for reconstructing phylogenetic trees. | N Saitou, M Nei | Mol Biol Evol | 1987 | 3447015 | Yes |
| 20 | 18369 | 18369.0 | 0.0 | 0.0 | Tissue sulfhydryl groups. | G L Ellman | Arch Biochem Biophys | 1959 | 13650640 | Yes |
| 21 | 53224 | 17741.3 | 0.0 | 0.0 | Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. | H Towbin, T Staehelin, J Gordon | Proc Natl Acad Sci U S A | 1979 | 388439 | Yes |
| 22 | 34399 | 17199.5 | 1195.28 | 597.6 | Hallmarks of cancer: the next generation. | Douglas Hanahan, Robert A Weinberg | Cell | 2011 | 21376230 | No |
| 23 | 33700 | 16850.0 | 1625.89 | 812.9 | Statistical methods for assessing agreement between two methods of clinical measurement. | J M Bland, D G Altman | Lancet | 1986 | 2868172 | Yes |
| 24 | 16804 | 16804.0 | 0.0 | 0.0 | Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. | B J Davis | Ann N Y Acad Sci | 1964 | 14240539 | Yes |
| 25 | 16275 | 16275.0 | 421.44 | 421.4 | Atherosclerosis--an inflammatory disease. | R Ross | N Engl J Med | 1999 | 9887164 | No |
| 26 | 16234 | 16234.0 | 0.0 | 0.0 | High resolution two-dimensional electrophoresis of proteins. | P H O'Farrell | J Biol Chem | 1975 | 236308 | Yes |
| 27 | 15908 | 15908.0 | 0.0 | 0.0 | A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. | K Burton | Biochem J | 1956 | 13293190 | Yes |
| 28 | 15706 | 15706.0 | 586.65 | 586.6 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. | M Kimura | J Mol Evol | 1980 | 7463489 | Yes |
| 29 | 30871 | 15435.5 | 0.0 | 0.0 | A rapid method of total lipid extraction and purification. | E G Bligh, W J Dyer | Can J Biochem Physiol | 1959 | 13671378 | Yes |
| 30 | 29923 | 14961.5 | 0.0 | 0.0 | The measurement of observer agreement for categorical data. | J R Landis, G G Koch | Biometrics | 1977 | 843571 | Yes |
| 31 | 43723 | 14574.3 | 1260.76 | 420.3 | CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. | J D Thompson, D G Higgins, T J Gibson | Nucleic Acids Res | 1994 | 7984417 | Yes |
| 32 | 13892 | 13892.0 | 376.67 | 376.7 | MicroRNAs: target recognition and regulatory functions. | David P Bartel | Cell | 2009 | 19167326 | No |
| 33 | 13785 | 13785.0 | 406.26 | 406.3 | Projector augmented-wave method. | Blöchl | Phys Rev B Condens Matter | 1994 | 9976227 | Yes |
| 34 | 40813 | 13604.3 | 0.0 | 0.0 | A simple method for the isolation and purification of total lipides from animal tissues. | J Folch, M Lees, G H Sloane Stanley | J Biol Chem | 1957 | 13428781 | Yes |
| 35 | 13347 | 13347.0 | 562.05 | 562.0 | A power primer. | J Cohen | Psychol Bull | 1992 | 19565683 | Yes |
| 36 | 26403 | 13201.5 | 1014.88 | 507.4 | Meta-analysis in clinical trials. | R DerSimonian, N Laird | Control Clin Trials | 1986 | 3802833 | Yes |
| 37 | 25957 | 12978.5 | 1073.85 | 536.9 | The hospital anxiety and depression scale. | A S Zigmond, R P Snaith | Acta Psychiatr Scand | 1983 | 6880820 | Yes |
| 38 | 12637 | 12637.0 | 636.63 | 636.6 | RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. | Alexandros Stamatakis | Bioinformatics | 2014 | 24451623 | Yes |
| 39 | 12624 | 12624.0 | 0.0 | 0.0 | Phosphorus assay in column chromatography. | G R Bartlett | J Biol Chem | 1959 | 13641241 | Yes |
| 40 | 12456 | 12456.0 | 493.4 | 493.4 | Catalase in vitro. | H Aebi | Methods Enzymol | 1984 | 6727660 | Yes |
| 41 | 35445 | 11815.0 | 1096.34 | 365.4 | Generalized Gradient Approximation Made Simple. | Perdew, Burke, Ernzerhof | Phys Rev Lett | 1996 | 10062328 | Yes |
| 42 | 56773 | 11354.6 | 1640.45 | 328.1 | Basic local alignment search tool. | S F Altschul, W Gish, W Miller, E W Myers, D J Lipman | J Mol Biol | 1990 | 2231712 | Yes |
| 43 | 22362 | 11181.0 | 943.04 | 471.5 | The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. | J E Ware, C D Sherbourne | Med Care | 1992 | 1593914 | Yes |
| 44 | 22233 | 11116.5 | 610.42 | 305.2 | Fast and accurate short read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2009 | 19451168 | Yes |
| 45 | 33129 | 11043.0 | 1207.68 | 402.6 | Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. | Lee, Yang, Parr | Phys Rev B Condens Matter | 1988 | 9944570 | Yes |
| 46 | 22035 | 11017.5 | 480.88 | 240.4 | Coot: model-building tools for molecular graphics. | Paul Emsley, Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2004 | 15572765 | Yes |
| 47 | 21570 | 10785.0 | 560.85 | 280.4 | A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. | A P Feinberg, B Vogelstein | Anal Biochem | 1983 | 6312838 | Yes |
| 48 | 10630 | 10630.0 | 357.72 | 357.7 | Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). | J F Kurtzke | Neurology | 1983 | 6685237 | Yes |
| 49 | 20974 | 10487.0 | 751.89 | 375.9 | Fast gapped-read alignment with Bowtie 2. | Ben Langmead, Steven L Salzberg | Nat Methods | 2012 | 22388286 | Yes |
| 50 | 10451 | 10451.0 | 373.87 | 373.9 | Search and clustering orders of magnitude faster than BLAST. | Robert C Edgar | Bioinformatics | 2010 | 20709691 | Yes |
| 51 | 10331 | 10331.0 | 0.0 | 0.0 | The genetics of Caenorhabditis elegans. | S Brenner | Genetics | 1974 | 4366476 | Yes |
| 52 | 10331 | 10331.0 | 0.0 | 0.0 | Improvements in epoxy resin embedding methods. | J H Luft | J Biophys Biochem Cytol | 1961 | 13764136 | Yes |
| 53 | 10237 | 10237.0 | 314.98 | 315.0 | The Psychophysics Toolbox. | D H Brainard | Spat Vis | 1997 | 9176952 | Yes |
| 54 | 20366 | 10183.0 | 455.9 | 227.9 | [20] Processing of X-ray diffraction data collected in oscillation mode. | Zbyszek Otwinowski, Wladek Minor | Methods Enzymol | 1997 | 27799103 | Yes |
| 55 | 10130 | 10130.0 | 385.49 | 385.5 | Structure validation in chemical crystallography. | Anthony L Spek | Acta Crystallogr D Biol Crystallogr | 2009 | 19171970 | Yes |
| 56 | 10093 | 10093.0 | 285.15 | 285.1 | Xds. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124692 | Yes |
| 57 | 19793 | 9896.5 | 0.0 | 0.0 | The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. | K Weber, M Osborn | J Biol Chem | 1969 | 5806584 | Yes |
| 58 | 9882 | 9882.0 | 0.0 | 0.0 | Self-efficacy: toward a unifying theory of behavioral change. | A Bandura | Psychol Rev | 1977 | 847061 | Yes |
| 59 | 9578 | 9578.0 | 614.72 | 614.7 | Crystal structure refinement with SHELXL. | George M Sheldrick | Acta Crystallogr C Struct Chem | 2015 | 25567568 | Yes |
| 60 | 9481 | 9481.0 | 371.55 | 371.6 | A new method for measuring daytime sleepiness: the Epworth sleepiness scale. | M W Johns | Sleep | 1991 | 1798888 | Yes |
| 61 | 9450 | 9450.0 | 322.41 | 322.4 | Banting lecture 1988. Role of insulin resistance in human disease. | G M Reaven | Diabetes | 1988 | 3056758 | No |
| 62 | 18518 | 9259.0 | 521.19 | 260.6 | Quantifying heterogeneity in a meta-analysis. | Julian P T Higgins, Simon G Thompson | Stat Med | 2002 | 12111919 | Yes |
| 63 | 9255 | 9255.0 | 269.71 | 269.7 | Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. | P S Thomas | Proc Natl Acad Sci U S A | 1980 | 6159641 | Yes |
| 64 | 18326 | 9163.0 | 826.48 | 413.2 | The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. | R M Baron, D A Kenny | J Pers Soc Psychol | 1986 | 3806354 | Yes |
| 65 | 18287 | 9143.5 | 480.86 | 240.4 | A simple method for displaying the hydropathic character of a protein. | J Kyte, R F Doolittle | J Mol Biol | 1982 | 7108955 | Yes |
| 66 | 9131 | 9131.0 | 243.01 | 243.0 | Studies on transformation of Escherichia coli with plasmids. | D Hanahan | J Mol Biol | 1983 | 6345791 | Yes |
| 67 | 9082 | 9082.0 | 260.38 | 260.4 | The pathogenesis of atherosclerosis: a perspective for the 1990s. | R Ross | Nature | 1993 | 8479518 | No |
| 68 | 17973 | 8986.5 | 520.0 | 260.0 | Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. | Kresse, Furthmüller | Phys Rev B Condens Matter | 1996 | 9984901 | Yes |
| 69 | 8972 | 8972.0 | 235.75 | 235.8 | Integrins: versatility, modulation, and signaling in cell adhesion. | R O Hynes | Cell | 1992 | 1555235 | No |
| 70 | 8741 | 8741.0 | 190.78 | 190.8 | Mfold web server for nucleic acid folding and hybridization prediction. | Michael Zuker | Nucleic Acids Res | 2003 | 12824337 | Yes |
| 71 | 8709 | 8709.0 | 249.04 | 249.0 | Evolutionary trees from DNA sequences: a maximum likelihood approach. | J Felsenstein | J Mol Evol | 1981 | 7288891 | Yes |
| 72 | 8626 | 8626.0 | 0.0 | 0.0 | On the origin of cancer cells. | O Warburg | Science | 1956 | 13298683 | Yes |
| 73 | 8600 | 8600.0 | 234.85 | 234.8 | RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. | Alexandros Stamatakis | Bioinformatics | 2006 | 16928733 | Yes |
| 74 | 8485 | 8485.0 | 262.51 | 262.5 | Vitamin D deficiency. | Michael F Holick | N Engl J Med | 2007 | 17634462 | No |
| 75 | 25295 | 8431.7 | 674.08 | 224.7 | VMD: visual molecular dynamics. | W Humphrey, A Dalke, K Schulten | J Mol Graph | 1996 | 8744570 | Yes |
| 76 | 16649 | 8324.5 | 362.68 | 181.3 | The hallmarks of cancer. | D Hanahan, R A Weinberg | Cell | 2000 | 10647931 | No |
| 77 | 33210 | 8302.5 | 993.78 | 248.4 | Measuring inconsistency in meta-analyses. | Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman | BMJ | 2003 | 12958120 | No |
| 78 | 8274 | 8274.0 | 175.44 | 175.4 | Linear models and empirical bayes methods for assessing differential expression in microarray experiments. | Gordon K Smyth | Stat Appl Genet Mol Biol | 2004 | 16646809 | Yes |
| 79 | 8152 | 8152.0 | 363.68 | 363.7 | Psychophysical bases of perceived exertion. | G A Borg | Med Sci Sports Exerc | 1982 | 7154893 | Yes |
| 80 | 32349 | 8087.2 | 1367.28 | 341.8 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | PLoS Med | 2009 | 19621072 | No |
| 81 | 8002 | 8002.0 | 0.0 | 0.0 | Solvent content of protein crystals. | B W Matthews | J Mol Biol | 1968 | 5700707 | Yes |
| 82 | 23925 | 7975.0 | 1027.15 | 342.4 | Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. | Michael I Love, Wolfgang Huber, Simon Anders | Genome Biol | 2014 | 25516281 | Yes |
| 83 | 7935 | 7935.0 | 174.82 | 174.8 | The functions of animal microRNAs. | Victor Ambros | Nature | 2004 | 15372042 | No |
| 84 | 7784 | 7784.0 | 223.81 | 223.8 | Semiempirical GGA-type density functional constructed with a long-range dispersion correction. | Stefan Grimme | J Comput Chem | 2006 | 16955487 | Yes |
| 85 | 7783 | 7783.0 | 218.62 | 218.6 | The role of protein kinase C in cell surface signal transduction and tumour promotion. | Y Nishizuka | Nature | 1984 | 6232463 | No |
| 86 | 7765 | 7765.0 | 218.59 | 218.6 | "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. | W N Burnette | Anal Biochem | 1981 | 6266278 | Yes |
| 87 | 7713 | 7713.0 | 0.0 | 0.0 | Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. | D I Arnon | Plant Physiol | 1949 | 16654194 | Yes |
| 88 | 7712 | 7712.0 | 0.0 | 0.0 | A simplification of the protein assay method of Lowry et al. which is more generally applicable. | G L Peterson | Anal Biochem | 1977 | 603028 | Yes |
| 89 | 7691 | 7691.0 | 207.39 | 207.4 | Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. | M C Hochberg | Arthritis Rheum | 1997 | 9324032 | Yes |
| 90 | 30679 | 7669.8 | 1173.38 | 293.3 | A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. | M E Charlson, P Pompei, K L Ales, C R MacKenzie | J Chronic Dis | 1987 | 3558716 | Yes |
| 91 | 15264 | 7632.0 | 356.26 | 178.1 | Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. | Kazutoshi Takahashi, Shinya Yamanaka | Cell | 2006 | 16904174 | Yes |
| 92 | 7588 | 7588.0 | 0.0 | 0.0 | Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. | J R Vane | Nat New Biol | 1971 | 5284360 | Yes |
| 93 | 22746 | 7582.0 | 632.56 | 210.9 | Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nat Protoc | 2009 | 19131956 | Yes |
| 94 | 7503 | 7503.0 | 288.86 | 288.9 | Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. | Andreas Stang | Eur J Epidemiol | 2010 | 20652370 | Yes |
| 95 | 22394 | 7464.7 | 851.03 | 283.7 | NIH Image to ImageJ: 25 years of image analysis. | Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri | Nat Methods | 2012 | 22930834 | No |
| 96 | 7292 | 7292.0 | 242.23 | 242.2 | The blockade of immune checkpoints in cancer immunotherapy. | Drew M Pardoll | Nat Rev Cancer | 2012 | 22437870 | No |
| 97 | 7263 | 7263.0 | 0.0 | 0.0 | A low-viscosity epoxy resin embedding medium for electron microscopy. | A R Spurr | J Ultrastruct Res | 1969 | 4887011 | Yes |
| 98 | 28828 | 7207.0 | 957.73 | 239.4 | Bias in meta-analysis detected by a simple, graphical test. | M Egger, G Davey Smith, M Schneider, C Minder | BMJ | 1997 | 9310563 | Yes |
| 99 | 7203 | 7203.0 | 0.0 | 0.0 | Tumor angiogenesis: therapeutic implications. | J Folkman | N Engl J Med | 1971 | 4938153 | No |
| 100 | 14406 | 7203.0 | 362.9 | 181.4 | MrBayes 3: Bayesian phylogenetic inference under mixed models. | Fredrik Ronquist, John P Huelsenbeck | Bioinformatics | 2003 | 12912839 | Yes |
| 101 | 14311 | 7155.5 | 403.18 | 201.6 | Analyzing real-time PCR data by the comparative C(T) method. | Thomas D Schmittgen, Kenneth J Livak | Nat Protoc | 2008 | 18546601 | Yes |
| 102 | 7098 | 7098.0 | 214.85 | 214.8 | AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. | R W Cox | Comput Biomed Res | 1996 | 8812068 | Yes |
| 103 | 7084 | 7084.0 | 193.78 | 193.8 | Canonical dynamics: Equilibrium phase-space distributions. | Hoover | Phys Rev A Gen Phys | 1985 | 9895674 | Yes |
| 104 | 7029 | 7029.0 | 180.06 | 180.1 | PAML 4: phylogenetic analysis by maximum likelihood. | Ziheng Yang | Mol Biol Evol | 2007 | 17483113 | Yes |
| 105 | 7012 | 7012.0 | 193.36 | 193.4 | TreeView: an application to display phylogenetic trees on personal computers. | R D Page | Comput Appl Biosci | 1996 | 8902363 | Yes |
| 106 | 7005 | 7005.0 | 0.0 | 0.0 | Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. | A Böyum | Scand J Clin Lab Invest Suppl | 1968 | 4179068 | Yes |
| 107 | 14009 | 7004.5 | 622.32 | 311.2 | MAFFT multiple sequence alignment software version 7: improvements in performance and usability. | Kazutaka Katoh, Daron M Standley | Mol Biol Evol | 2013 | 23329690 | Yes |
| 108 | 20955 | 6985.0 | 0.0 | 0.0 | Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. | W T Friedewald, R I Levy, D S Fredrickson | Clin Chem | 1972 | 4337382 | Yes |
| 109 | 48858 | 6979.7 | 1284.36 | 183.5 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. | S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J Lipman | Nucleic Acids Res | 1997 | 9254694 | No |
| 110 | 6972 | 6972.0 | 237.85 | 237.8 | Density-functional approximation for the correlation energy of the inhomogeneous electron gas. | Perdew | Phys Rev B Condens Matter | 1986 | 9938299 | Yes |
| 111 | 20769 | 6923.0 | 961.24 | 320.4 | Trimmomatic: a flexible trimmer for Illumina sequence data. | Anthony M Bolger, Marc Lohse, Bjoern Usadel | Bioinformatics | 2014 | 24695404 | Yes |
| 112 | 6888 | 6888.0 | 156.94 | 156.9 | Chromatin modifications and their function. | Tony Kouzarides | Cell | 2007 | 17320507 | No |
| 113 | 6850 | 6850.0 | 324.64 | 324.6 | Comparative fit indexes in structural models. | P M Bentler | Psychol Bull | 1990 | 2320703 | Yes |
| 114 | 6842 | 6842.0 | 184.69 | 184.7 | Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. | F Tajima | Genetics | 1989 | 2513255 | Yes |
| 115 | 6833 | 6833.0 | 318.2 | 318.2 | Investigation of the freely available easy-to-use software 'EZR' for medical statistics. | Y Kanda | Bone Marrow Transplant | 2013 | 23208313 | Yes |
| 116 | 13641 | 6820.5 | 302.13 | 151.1 | KEGG: kyoto encyclopedia of genes and genomes. | M Kanehisa, S Goto | Nucleic Acids Res | 2000 | 10592173 | Yes |
| 117 | 6791 | 6791.0 | 184.86 | 184.9 | The steroid and thyroid hormone receptor superfamily. | R M Evans | Science | 1988 | 3283939 | No |
| 118 | 13526 | 6763.0 | 0.0 | 0.0 | Continuous cultures of fused cells secreting antibody of predefined specificity. | G Köhler, C Milstein | Nature | 1975 | 1172191 | Yes |
| 119 | 13490 | 6745.0 | 288.98 | 144.5 | Processing of X-ray diffraction data collected in oscillation mode. | Z Otwinowski, W Minor | Methods Enzymol | 1997 | 27754618 | Yes |
| 120 | 13409 | 6704.5 | 308.7 | 154.3 | Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. | S J Clough, A F Bent | Plant J | 1998 | 10069079 | Yes |
| 121 | 6696 | 6696.0 | 0.0 | 0.0 | The thiobarbituric acid assay of sialic acids. | L Warren | J Biol Chem | 1959 | 13672998 | Yes |
| 122 | 6627 | 6627.0 | 170.38 | 170.4 | Fast robust automated brain extraction. | Stephen M Smith | Hum Brain Mapp | 2002 | 12391568 | No |
| 123 | 6611 | 6611.0 | 0.0 | 0.0 | The assessment of anxiety states by rating. | M Hamilton | Br J Med Psychol | 1959 | 13638508 | Yes |
| 124 | 6598 | 6598.0 | 184.93 | 184.9 | Apoptosis: a review of programmed cell death. | Susan Elmore | Toxicol Pathol | 2007 | 17562483 | No |
| 125 | 19766 | 6588.7 | 564.03 | 188.0 | A new generation of Ca2+ indicators with greatly improved fluorescence properties. | G Grynkiewicz, M Poenie, R Y Tsien | J Biol Chem | 1985 | 3838314 | Yes |
| 126 | 6513 | 6513.0 | 172.56 | 172.6 | Adhesion receptors of the immune system. | T A Springer | Nature | 1990 | 1974032 | No |
| 127 | 6433 | 6433.0 | 198.23 | 198.2 | The VideoToolbox software for visual psychophysics: transforming numbers into movies. | D G Pelli | Spat Vis | 1997 | 9176953 | Yes |
| 128 | 6411 | 6411.0 | 169.2 | 169.2 | Angiogenesis in cancer, vascular, rheumatoid and other disease. | J Folkman | Nat Med | 1995 | 7584949 | No |
| 129 | 12776 | 6388.0 | 0.0 | 0.0 | Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. | Y Cheng, W H Prusoff | Biochem Pharmacol | 1973 | 4202581 | Yes |
| 130 | 6368 | 6368.0 | 130.69 | 130.7 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel | Proc Natl Acad Sci U S A | 1985 | 3881765 | Yes |
| 131 | 19019 | 6339.7 | 1373.48 | 457.8 | MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. | Sudhir Kumar, Glen Stecher, Koichiro Tamura | Mol Biol Evol | 2016 | 27004904 | Yes |
| 132 | 12668 | 6334.0 | 0.0 | 0.0 | Statistical aspects of the analysis of data from retrospective studies of disease. | N Mantel, W Haenszel | J Natl Cancer Inst | 1959 | 13655060 | Yes |
| 133 | 6265 | 6265.0 | 208.29 | 208.3 | Ethical guidelines for investigations of experimental pain in conscious animals. | Manfred Zimmermann | Pain | 1983 | 6877845 | No |
| 134 | 6193 | 6193.0 | 135.32 | 135.3 | p53, the cellular gatekeeper for growth and division. | A J Levine | Cell | 1997 | 9039259 | No |
| 135 | 6175 | 6175.0 | 202.68 | 202.7 | The Clinical Dementia Rating (CDR): current version and scoring rules. | J C Morris | Neurology | 1993 | 8232972 | Yes |
| 136 | 12215 | 6107.5 | 0.0 | 0.0 | A rapid alkaline extraction procedure for screening recombinant plasmid DNA. | H C Birnboim, J Doly | Nucleic Acids Res | 1979 | 388356 | Yes |
| 137 | 36409 | 6068.2 | 3693.65 | 615.6 | Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. | Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal | CA Cancer J Clin | 2018 | 30207593 | Yes |
| 138 | 6039 | 6039.0 | 150.25 | 150.2 | Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. | T A Springer | Cell | 1994 | 7507411 | No |
| 139 | 12037 | 6018.5 | 0.0 | 0.0 | Prediction of creatinine clearance from serum creatinine. | D W Cockcroft, M H Gault | Nephron | 1976 | 1244564 | Yes |
| 140 | 6016 | 6016.0 | 124.23 | 124.2 | Integrins: bidirectional, allosteric signaling machines. | Richard O Hynes | Cell | 2002 | 12297042 | No |
| 141 | 24011 | 6002.8 | 0.0 | 0.0 | Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. | J M Chirgwin, A E Przybyla, R J MacDonald, W J Rutter | Biochemistry | 1979 | 518835 | Yes |
| 142 | 5973 | 5973.0 | 152.71 | 152.7 | Inositol trisphosphate and calcium signalling. | M J Berridge | Nature | 1993 | 8381210 | No |
| 143 | 5942 | 5942.0 | 152.44 | 152.4 | G proteins: transducers of receptor-generated signals. | A G Gilman | Annu Rev Biochem | 1987 | 3113327 | No |
| 144 | 5911 | 5911.0 | 134.4 | 134.4 | Inflammation in atherosclerosis. | Peter Libby | Nature | 2002 | 12490960 | No |
| 145 | 11767 | 5883.5 | 0.0 | 0.0 | Intraclass correlations: uses in assessing rater reliability. | P E Shrout, J L Fleiss | Psychol Bull | 1979 | 18839484 | No |
| 146 | 5868 | 5868.0 | 145.89 | 145.9 | Inflammation, atherosclerosis, and coronary artery disease. | Göran K Hansson | N Engl J Med | 2005 | 15843671 | No |
| 147 | 5792 | 5792.0 | 286.67 | 286.7 | UPARSE: highly accurate OTU sequences from microbial amplicon reads. | Robert C Edgar | Nat Methods | 2013 | 23955772 | Yes |
| 148 | 11563 | 5781.5 | 409.02 | 204.5 | The meaning and use of the area under a receiver operating characteristic (ROC) curve. | J A Hanley, B J McNeil | Radiology | 1982 | 7063747 | Yes |
| 149 | 5756 | 5756.0 | 311.55 | 311.6 | Prokka: rapid prokaryotic genome annotation. | Torsten Seemann | Bioinformatics | 2014 | 24642063 | Yes |
| 150 | 17211 | 5737.0 | 552.56 | 184.2 | Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. | Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien | Ann Surg | 2004 | 15273542 | Yes |
| 151 | 5730 | 5730.0 | 140.34 | 140.3 | Biochemistry and molecular cell biology of diabetic complications. | M Brownlee | Nature | 2001 | 11742414 | Yes |
| 152 | 5711 | 5711.0 | 0.0 | 0.0 | A Self-Rating Depression Scale. | W W Zung | Arch Gen Psychiatry | 1965 | 14221692 | Yes |
| 153 | 5678 | 5678.0 | 137.96 | 138.0 | Free radicals in the physiological control of cell function. | Wulf Dröge | Physiol Rev | 2002 | 11773609 | No |
| 154 | 11344 | 5672.0 | 0.0 | 0.0 | The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. | T Omura, R Sato | J Biol Chem | 1964 | 14209971 | Yes |
| 155 | 5671 | 5671.0 | 144.41 | 144.4 | Apoptosis in the pathogenesis and treatment of disease. | C B Thompson | Science | 1995 | 7878464 | No |
| 156 | 16940 | 5646.7 | 493.02 | 164.3 | edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. | Mark D Robinson, Davis J McCarthy, Gordon K Smyth | Bioinformatics | 2010 | 19910308 | Yes |
| 157 | 5638 | 5638.0 | 203.49 | 203.5 | The Strengths and Difficulties Questionnaire: a research note. | R Goodman | J Child Psychol Psychiatry | 1997 | 9255702 | Yes |
| 158 | 11136 | 5568.0 | 301.26 | 150.6 | Sequencing end-labeled DNA with base-specific chemical cleavages. | A M Maxam, W Gilbert | Methods Enzymol | 1980 | 6246368 | Yes |
| 159 | 11130 | 5565.0 | 277.69 | 138.8 | MRBAYES: Bayesian inference of phylogenetic trees. | J P Huelsenbeck, F Ronquist | Bioinformatics | 2001 | 11524383 | Yes |
| 160 | 16665 | 5555.0 | 0.0 | 0.0 | Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. | H Ohkawa, N Ohishi, K Yagi | Anal Biochem | 1979 | 36810 | Yes |
| 161 | 11019 | 5509.5 | 252.08 | 126.0 | Dendritic cells and the control of immunity. | J Banchereau, R M Steinman | Nature | 1998 | 9521319 | No |
| 162 | 5502 | 5502.0 | 107.33 | 107.3 | BLAT--the BLAST-like alignment tool. | W James Kent | Genome Res | 2002 | 11932250 | Yes |
| 163 | 10913 | 5456.5 | 0.0 | 0.0 | A series of normal stages in the development of the chick embryo. | V Hamburger, H L Hamilton | J Morphol | 1951 | 24539719 | Yes |
| 164 | 16361 | 5453.7 | 503.55 | 167.8 | The PHQ-9: validity of a brief depression severity measure. | K Kroenke, R L Spitzer, J B Williams | J Gen Intern Med | 2001 | 11556941 | Yes |
| 165 | 5449 | 5449.0 | 0.0 | 0.0 | Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. | F Tietze | Anal Biochem | 1969 | 4388022 | Yes |
| 166 | 5440 | 5440.0 | 130.74 | 130.7 | Antimicrobial peptides of multicellular organisms. | Michael Zasloff | Nature | 2002 | 11807545 | Yes |
| 167 | 10819 | 5409.5 | 388.31 | 194.2 | Three approaches to qualitative content analysis. | Hsiu-Fang Hsieh, Sarah E Shannon | Qual Health Res | 2005 | 16204405 | Yes |
| 168 | 5369 | 5369.0 | 0.0 | 0.0 | Modification of seizure activity by electrical stimulation. II. Motor seizure. | R J Racine | Electroencephalogr Clin Neurophysiol | 1972 | 4110397 | Yes |
| 169 | 5350 | 5350.0 | 136.91 | 136.9 | New M13 vectors for cloning. | J Messing | Methods Enzymol | 1983 | 6310323 | Yes |
| 170 | 5338 | 5338.0 | 0.0 | 0.0 | Evaluation of survival data and two new rank order statistics arising in its consideration. | N Mantel | Cancer Chemother Rep | 1966 | 5910392 | Yes |
| 171 | 5329 | 5329.0 | 119.51 | 119.5 | The biochemistry of apoptosis. | M O Hengartner | Nature | 2000 | 11048727 | No |
| 172 | 10633 | 5316.5 | 250.63 | 125.3 | Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. | W Kabsch, C Sander | Biopolymers | 1983 | 6667333 | Yes |
| 173 | 5287 | 5287.0 | 124.57 | 124.6 | Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. | J Castresana | Mol Biol Evol | 2000 | 10742046 | Yes |
| 174 | 5276 | 5276.0 | 141.26 | 141.3 | The Cambridge Structural Database: a quarter of a million crystal structures and rising. | Frank H Allen | Acta Crystallogr B | 2002 | 12037359 | Yes |
| 175 | 15825 | 5275.0 | 479.72 | 159.9 | A simple salting out procedure for extracting DNA from human nucleated cells. | S A Miller, D D Dykes, H F Polesky | Nucleic Acids Res | 1988 | 3344216 | Yes |
| 176 | 5269 | 5269.0 | 153.67 | 153.7 | Studies and perspectives of protein kinase C. | Y Nishizuka | Science | 1986 | 3014651 | No |
| 177 | 5262 | 5262.0 | 134.48 | 134.5 | Inflammation and metabolic disorders. | Gökhan S Hotamisligil | Nature | 2006 | 17167474 | No |
| 178 | 5255 | 5255.0 | 325.78 | 325.8 | SHELXT - integrated space-group and crystal-structure determination. | George M Sheldrick | Acta Crystallogr A Found Adv | 2015 | 25537383 | Yes |
| 179 | 10504 | 5252.0 | 300.45 | 150.2 | MODELTEST: testing the model of DNA substitution. | D Posada, K A Crandall | Bioinformatics | 1998 | 9918953 | Yes |
| 180 | 5252 | 5252.0 | 0.0 | 0.0 | The Environment And Disease: Association Or Causation? | A B Hill | Proc R Soc Med | 1965 | 14283879 | Yes |
| 181 | 10458 | 5229.0 | 252.24 | 126.1 | A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. | Stéphane Guindon, Olivier Gascuel | Syst Biol | 2003 | 14530136 | Yes |
| 182 | 5221 | 5221.0 | 0.0 | 0.0 | [A micro-method of immuno-electrophoresis]. | J J Scheidegger | Int Arch Allergy Appl Immunol | 1955 | 13262900 | Yes |
| 183 | 5207 | 5207.0 | 0.0 | 0.0 | Mutation and cancer: statistical study of retinoblastoma. | A G Knudson | Proc Natl Acad Sci U S A | 1971 | 5279523 | Yes |
| 184 | 5197 | 5197.0 | 0.0 | 0.0 | Aging: a theory based on free radical and radiation chemistry. | D Harman | J Gerontol | 1956 | 13332224 | Yes |
| 185 | 5186 | 5186.0 | 0.0 | 0.0 | Selective extraction of polyoma DNA from infected mouse cell cultures. | B Hirt | J Mol Biol | 1967 | 4291934 | Yes |
| 186 | 5182 | 5182.0 | 190.66 | 190.7 | Oxygen-derived free radicals in postischemic tissue injury. | J M McCord | N Engl J Med | 1985 | 2981404 | No |
| 187 | 5182 | 5182.0 | 175.77 | 175.8 | jModelTest: phylogenetic model averaging. | David Posada | Mol Biol Evol | 2008 | 18397919 | Yes |
| 188 | 10343 | 5171.5 | 234.97 | 117.5 | One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. | K A Datsenko, B L Wanner | Proc Natl Acad Sci U S A | 2000 | 10829079 | Yes |
| 189 | 5162 | 5162.0 | 126.77 | 126.8 | The NF-kappa B and I kappa B proteins: new discoveries and insights. | A S Baldwin | Annu Rev Immunol | 1996 | 8717528 | No |
| 190 | 10313 | 5156.5 | 351.01 | 175.5 | AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. | Oleg Trott, Arthur J Olson | J Comput Chem | 2010 | 19499576 | Yes |
| 191 | 25768 | 5153.6 | 705.29 | 141.1 | The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. | J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G Higgins | Nucleic Acids Res | 1997 | 9396791 | Yes |
| 192 | 5137 | 5137.0 | 208.93 | 208.9 | Orienting of attention. | M I Posner | Q J Exp Psychol | 1980 | 7367577 | Yes |
| 193 | 5108 | 5108.0 | 0.0 | 0.0 | Development of a rating scale for primary depressive illness. | M Hamilton | Br J Soc Clin Psychol | 1967 | 6080235 | Yes |
| 194 | 5093 | 5093.0 | 143.62 | 143.6 | A modified poisson regression approach to prospective studies with binary data. | Guangyong Zou | Am J Epidemiol | 2004 | 15033648 | Yes |
| 195 | 10160 | 5080.0 | 374.75 | 187.4 | The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. | R F Furchgott, J V Zawadzki | Nature | 1980 | 6253831 | Yes |
| 196 | 10151 | 5075.5 | 286.11 | 143.1 | Neuropathological stageing of Alzheimer-related changes. | H Braak, E Braak | Acta Neuropathol | 1991 | 1759558 | No |
| 197 | 10083 | 5041.5 | 269.0 | 134.5 | Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. | H Schägger, G von Jagow | Anal Biochem | 1987 | 2449095 | Yes |
| 198 | 10078 | 5039.0 | 261.9 | 130.9 | BEDTools: a flexible suite of utilities for comparing genomic features. | Aaron R Quinlan, Ira M Hall | Bioinformatics | 2010 | 20110278 | Yes |
| 199 | 5015 | 5015.0 | 185.64 | 185.6 | Analyzing Tables Of Statistical Tests. | William R Rice | Evolution | 1989 | 28568501 | Yes |
| 200 | 4988 | 4988.0 | 0.0 | 0.0 | A protein binding assay for adenosine 3':5'-cyclic monophosphate. | A G Gilman | Proc Natl Acad Sci U S A | 1970 | 4318781 | Yes |
| 201 | 4981 | 4981.0 | 102.39 | 102.4 | Rho GTPases and the actin cytoskeleton. | A Hall | Science | 1998 | 9438836 | No |
| 202 | 4962 | 4962.0 | 100.55 | 100.5 | Epithelial-mesenchymal transitions in tumour progression. | Jean Paul Thiery | Nat Rev Cancer | 2002 | 12189386 | No |
| 203 | 19829 | 4957.2 | 687.88 | 172.0 | G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. | Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner | Behav Res Methods | 2007 | 17695343 | Yes |
| 204 | 14837 | 4945.7 | 540.62 | 180.2 | Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. | S M Hsu, L Raine, H Fanger | J Histochem Cytochem | 1981 | 6166661 | Yes |
| 205 | 9886 | 4943.0 | 285.22 | 142.6 | EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. | Arnaud Delorme, Scott Makeig | J Neurosci Methods | 2004 | 15102499 | Yes |
| 206 | 4928 | 4928.0 | 0.0 | 0.0 | Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. | C B Laurell | Anal Biochem | 1966 | 5959431 | Yes |
| 207 | 4925 | 4925.0 | 148.82 | 148.8 | Developments of a water-maze procedure for studying spatial learning in the rat. | R Morris | J Neurosci Methods | 1984 | 6471907 | Yes |
| 208 | 9803 | 4901.5 | 357.31 | 178.7 | Ligand: a versatile computerized approach for characterization of ligand-binding systems. | P J Munson, D Rodbard | Anal Biochem | 1980 | 6254391 | Yes |
| 209 | 9758 | 4879.0 | 0.0 | 0.0 | A quantitative description of membrane current and its application to conduction and excitation in nerve. | A L Hodgkin, A F Huxley | J Physiol | 1952 | 12991237 | Yes |
| 210 | 14527 | 4842.3 | 396.35 | 132.1 | Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. | C Yanisch-Perron, J Vieira, J Messing | Gene | 1985 | 2985470 | Yes |
| 211 | 14480 | 4826.7 | 361.54 | 120.5 | A comprehensive set of sequence analysis programs for the VAX. | J Devereux, P Haeberli, O Smithies | Nucleic Acids Res | 1984 | 6546423 | Yes |
| 212 | 4825 | 4825.0 | 0.0 | 0.0 | Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. | M Rodbell | J Biol Chem | 1964 | 14169133 | Yes |
| 213 | 4820 | 4820.0 | 0.0 | 0.0 | The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. | P Lauren | Acta Pathol Microbiol Scand | 1965 | 14320675 | Yes |
| 214 | 4794 | 4794.0 | 97.69 | 97.7 | An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. | M Kozak | Nucleic Acids Res | 1987 | 3313277 | No |
| 215 | 4779 | 4779.0 | 120.3 | 120.3 | Emotion circuits in the brain. | J E LeDoux | Annu Rev Neurosci | 2000 | 10845062 | No |
| 216 | 9544 | 4772.0 | 211.46 | 105.7 | Inflammation and cancer. | Lisa M Coussens, Zena Werb | Nature | 2002 | 12490959 | No |
| 217 | 9532 | 4766.0 | 230.99 | 115.5 | Comparative protein modelling by satisfaction of spatial restraints. | A Sali, T L Blundell | J Mol Biol | 1993 | 8254673 | Yes |
| 218 | 4747 | 4747.0 | 141.53 | 141.5 | A fast diffeomorphic image registration algorithm. | John Ashburner | Neuroimage | 2007 | 17761438 | Yes |
| 219 | 14227 | 4742.3 | 0.0 | 0.0 | Determination of serum proteins by means of the biuret reaction. | A G Gornall, C J Bardawill, M M David | J Biol Chem | 1949 | 18110453 | Yes |
| 220 | 9478 | 4739.0 | 0.0 | 0.0 | A new technique for the assay of infectivity of human adenovirus 5 DNA. | F L Graham, A J van der Eb | Virology | 1973 | 4705382 | Yes |
| 221 | 9455 | 4727.5 | 0.0 | 0.0 | A new depression scale designed to be sensitive to change. | S A Montgomery, M Asberg | Br J Psychiatry | 1979 | 444788 | Yes |
| 222 | 9422 | 4711.0 | 230.64 | 115.3 | A genetic model for colorectal tumorigenesis. | E R Fearon, B Vogelstein | Cell | 1990 | 2188735 | No |
| 223 | 14103 | 4701.0 | 541.27 | 180.4 | The positive and negative syndrome scale (PANSS) for schizophrenia. | S R Kay, A Fiszbein, L A Opler | Schizophr Bull | 1987 | 3616518 | Yes |
| 224 | 4693 | 4693.0 | 0.0 | 0.0 | Index for rating diagnostic tests. | W J Youden | Cancer | 1950 | 15405679 | Yes |
| 225 | 4685 | 4685.0 | 107.0 | 107.0 | ras oncogenes in human cancer: a review. | J L Bos | Cancer Res | 1989 | 2547513 | No |
| 226 | 4680 | 4680.0 | 130.57 | 130.6 | Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. | P Matsudaira | J Biol Chem | 1987 | 3611052 | Yes |
| 227 | 9347 | 4673.5 | 238.07 | 119.0 | Improved tools for biological sequence comparison. | W R Pearson, D J Lipman | Proc Natl Acad Sci U S A | 1988 | 3162770 | Yes |
| 228 | 4673 | 4673.0 | 158.98 | 159.0 | The pathogenesis of atherosclerosis--an update. | R Ross | N Engl J Med | 1986 | 3511384 | No |
| 229 | 4670 | 4670.0 | 108.29 | 108.3 | MUSCLE: a multiple sequence alignment method with reduced time and space complexity. | Robert C Edgar | BMC Bioinformatics | 2004 | 15318951 | Yes |
| 230 | 9328 | 4664.0 | 211.12 | 105.6 | The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. | John Hardy, Dennis J Selkoe | Science | 2002 | 12130773 | No |
| 231 | 4657 | 4657.0 | 104.34 | 104.3 | Cancer cell cycles. | C J Sherr | Science | 1996 | 8939849 | No |
| 232 | 13874 | 4624.7 | 485.84 | 161.9 | Nitric oxide: physiology, pathophysiology, and pharmacology. | S Moncada, R M Palmer, E A Higgs | Pharmacol Rev | 1991 | 1852778 | No |
| 233 | 4612 | 4612.0 | 0.0 | 0.0 | Aggregation of blood platelets by adenosine diphosphate and its reversal. | G V Born | Nature | 1962 | 13871375 | Yes |
| 234 | 4608 | 4608.0 | 0.0 | 0.0 | The clonal evolution of tumor cell populations. | P C Nowell | Science | 1976 | 959840 | Yes |
| 235 | 18405 | 4601.2 | 562.27 | 140.6 | MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. | Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir Kumar | Mol Biol Evol | 2007 | 17488738 | Yes |
| 236 | 4598 | 4598.0 | 0.0 | 0.0 | A rapid banding technique for human chromosomes. | M Seabright | Lancet | 1971 | 4107917 | Yes |
| 237 | 4598 | 4598.0 | 97.63 | 97.6 | Targeting HIF-1 for cancer therapy. | Gregg L Semenza | Nat Rev Cancer | 2003 | 13130303 | No |
| 238 | 22756 | 4551.2 | 1140.74 | 228.1 | MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. | Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir Kumar | Mol Biol Evol | 2013 | 24132122 | Yes |
| 239 | 13602 | 4534.0 | 345.23 | 115.1 | Inference of population structure using multilocus genotype data. | J K Pritchard, M Stephens, P Donnelly | Genetics | 2000 | 10835412 | Yes |
| 240 | 4523 | 4523.0 | 126.03 | 126.0 | Mild cognitive impairment as a diagnostic entity. | R C Petersen | J Intern Med | 2004 | 15324362 | No |
| 241 | 13527 | 4509.0 | 302.64 | 100.9 | Refinement of macromolecular structures by the maximum-likelihood method. | G N Murshudov, A A Vagin, E J Dodson | Acta Crystallogr D Biol Crystallogr | 1997 | 15299926 | Yes |
| 242 | 22474 | 4494.8 | 0.0 | 0.0 | An inventory for measuring depression. | A T Beck, C H Ward, M Mendelson, J Mock, J Erbaugh | Arch Gen Psychiatry | 1961 | 13688369 | Yes |
| 243 | 4485 | 4485.0 | 0.0 | 0.0 | The McGill Pain Questionnaire: major properties and scoring methods. | Ronald Melzack | Pain | 1975 | 1235985 | Yes |
| 244 | 4484 | 4484.0 | 98.04 | 98.0 | ras genes. | M Barbacid | Annu Rev Biochem | 1987 | 3304147 | No |
| 245 | 4479 | 4479.0 | 87.36 | 87.4 | DNA methylation patterns and epigenetic memory. | Adrian Bird | Genes Dev | 2002 | 11782440 | No |
| 246 | 8943 | 4471.5 | 302.15 | 151.1 | Operating characteristics of a rank correlation test for publication bias. | C B Begg, M Mazumdar | Biometrics | 1994 | 7786990 | Yes |
| 247 | 4464 | 4464.0 | 102.13 | 102.1 | Alzheimer's disease: genes, proteins, and therapy. | D J Selkoe | Physiol Rev | 2001 | 11274343 | No |
| 248 | 4461 | 4461.0 | 109.56 | 109.6 | A new method for predicting signal sequence cleavage sites. | G von Heijne | Nucleic Acids Res | 1986 | 3714490 | Yes |
| 249 | 4460 | 4460.0 | 176.05 | 176.1 | An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. | Peter C Austin | Multivariate Behav Res | 2011 | 21818162 | Yes |
| 250 | 8903 | 4451.5 | 248.96 | 124.5 | Differential expression analysis for sequence count data. | Simon Anders, Wolfgang Huber | Genome Biol | 2010 | 20979621 | Yes |
| 251 | 8889 | 4444.5 | 0.0 | 0.0 | A simplified method of evaluating dose-effect experiments. | J T Litchfield, F Wilcoxon | J Pharmacol Exp Ther | 1949 | 18152921 | Yes |
| 252 | 8880 | 4440.0 | 0.0 | 0.0 | Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). | J M McCord, I Fridovich | J Biol Chem | 1969 | 5389100 | Yes |
| 253 | 4413 | 4413.0 | 0.0 | 0.0 | Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. | W H Harris | J Bone Joint Surg Am | 1969 | 5783851 | Yes |
| 254 | 8825 | 4412.5 | 201.49 | 100.7 | Primer3 on the WWW for general users and for biologist programmers. | S Rozen, H Skaletsky | Methods Mol Biol | 2000 | 10547847 | Yes |
| 255 | 4398 | 4398.0 | 101.28 | 101.3 | Prions. | S B Prusiner | Proc Natl Acad Sci U S A | 1998 | 9811807 | No |
| 256 | 8788 | 4394.0 | 0.0 | 0.0 | A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. | W M Bonner, R A Laskey | Eur J Biochem | 1974 | 4850204 | Yes |
| 257 | 4384 | 4384.0 | 172.85 | 172.8 | Revisiting the behavioral model and access to medical care: does it matter? | R M Andersen | J Health Soc Behav | 1995 | 7738325 | Yes |
| 258 | 8747 | 4373.5 | 0.0 | 0.0 | Parkinsonism: onset, progression and mortality. | M M Hoehn, M D Yahr | Neurology | 1967 | 6067254 | Yes |
| 259 | 4373 | 4373.0 | 90.04 | 90.0 | Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. | M Kozak | Cell | 1986 | 3943125 | Yes |
| 260 | 4373 | 4373.0 | 0.0 | 0.0 | The Limited In Vitro Lifetime Of Human Diploid Cell Strains. | L Hayflick | Exp Cell Res | 1965 | 14315085 | Yes |
| 261 | 4344 | 4344.0 | 0.0 | 0.0 | Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. | M M Mesulam | J Histochem Cytochem | 1978 | 24068 | Yes |
| 262 | 4342 | 4342.0 | 0.0 | 0.0 | The need for a new medical model: a challenge for biomedicine. | G L Engel | Science | 1977 | 847460 | Yes |
| 263 | 4318 | 4318.0 | 113.09 | 113.1 | Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. | Y Nishizuka | Science | 1992 | 1411571 | No |
| 264 | 8599 | 4299.5 | 0.0 | 0.0 | Preparation of iodine-131 labelled human growth hormone of high specific activity. | W M Hunter, F C Greenwood | Nature | 1962 | 14450081 | Yes |
| 265 | 8593 | 4296.5 | 249.88 | 124.9 | The rise of graphene. | A K Geim, K S Novoselov | Nat Mater | 2007 | 17330084 | Yes |
| 266 | 25755 | 4292.5 | 995.85 | 166.0 | Global cancer statistics. | Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David Forman | CA Cancer J Clin | 2011 | 21296855 | Yes |
| 267 | 4288 | 4288.0 | 101.39 | 101.4 | Cancer. p53, guardian of the genome. | D P Lane | Nature | 1992 | 1614522 | No |
| 268 | 4269 | 4269.0 | 113.99 | 114.0 | The molecular heterogeneity of protein kinase C and its implications for cellular regulation. | Y Nishizuka | Nature | 1988 | 3045562 | No |
| 269 | 8518 | 4259.0 | 231.91 | 116.0 | A synaptic model of memory: long-term potentiation in the hippocampus. | T V Bliss, G L Collingridge | Nature | 1993 | 8421494 | No |
| 270 | 4253 | 4253.0 | 126.87 | 126.9 | How mitochondria produce reactive oxygen species. | Michael P Murphy | Biochem J | 2009 | 19061483 | No |
| 271 | 8488 | 4244.0 | 0.0 | 0.0 | Assessment of coma and impaired consciousness. A practical scale. | G Teasdale, B Jennett | Lancet | 1974 | 4136544 | Yes |
| 272 | 4239 | 4239.0 | 94.09 | 94.1 | Apoptosis by death factor. | S Nagata | Cell | 1997 | 9039262 | No |
| 273 | 16939 | 4234.8 | 0.0 | 0.0 | A new and rapid colorimetric determination of acetylcholinesterase activity. | G L Ellman, K D Courtney, V Andres, R M Feather-Stone | Biochem Pharmacol | 1961 | 13726518 | Yes |
| 274 | 4233 | 4233.0 | 0.0 | 0.0 | The genetical evolution of social behaviour. I. | W D Hamilton | J Theor Biol | 1964 | 5875341 | Yes |
| 275 | 4233 | 4233.0 | 113.23 | 113.2 | Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. | A H Wyllie | Nature | 1980 | 6245367 | Yes |
| 276 | 4219 | 4219.0 | 0.0 | 0.0 | Amino acid metabolism in mammalian cell cultures. | H Eagle | Science | 1959 | 13675766 | Yes |
| 277 | 4213 | 4213.0 | 94.88 | 94.9 | Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. | S Henikoff | Gene | 1984 | 6235151 | Yes |
| 278 | 4199 | 4199.0 | 0.0 | 0.0 | Estimation of nuclear population from microtome sections. | M Abercrombie | Anat Rec | 1946 | 21015608 | Yes |
| 279 | 4196 | 4196.0 | 90.54 | 90.5 | Alternative activation of macrophages. | Siamon Gordon | Nat Rev Immunol | 2003 | 12511873 | No |
| 280 | 4193 | 4193.0 | 0.0 | 0.0 | A relation between non-esterified fatty acids in plasma and the metabolism of glucose. | V P Dole | J Clin Invest | 1956 | 13286333 | Yes |
| 281 | 4191 | 4191.0 | 0.0 | 0.0 | The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. | T Nash | Biochem J | 1953 | 13105648 | Yes |
| 282 | 8379 | 4189.5 | 197.26 | 98.6 | SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. | N Guex, M C Peitsch | Electrophoresis | 1997 | 9504803 | Yes |
| 283 | 25011 | 4168.5 | 1020.2 | 170.0 | MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. | Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir Kumar | Mol Biol Evol | 2011 | 21546353 | Yes |
| 284 | 4159 | 4159.0 | 99.55 | 99.5 | Mechanisms of angiogenesis. | W Risau | Nature | 1997 | 9109485 | No |
| 285 | 8290 | 4145.0 | 256.14 | 128.1 | RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. | Bo Li, Colin N Dewey | BMC Bioinformatics | 2011 | 21816040 | Yes |
| 286 | 4136 | 4136.0 | 87.36 | 87.4 | The retinoblastoma protein and cell cycle control. | R A Weinberg | Cell | 1995 | 7736585 | No |
| 287 | 4130 | 4130.0 | 126.15 | 126.2 | Glutamate neurotoxicity and diseases of the nervous system. | D W Choi | Neuron | 1988 | 2908446 | No |
| 288 | 8255 | 4127.5 | 179.44 | 89.7 | Genomic sequencing. | G M Church, W Gilbert | Proc Natl Acad Sci U S A | 1984 | 6326095 | Yes |
| 289 | 8241 | 4120.5 | 231.95 | 116.0 | Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. | Florian Weigend, Reinhart Ahlrichs | Phys Chem Chem Phys | 2005 | 16240044 | Yes |
| 290 | 4120 | 4120.0 | 87.24 | 87.2 | Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. | C J Marshall | Cell | 1995 | 7834738 | No |
| 291 | 4111 | 4111.0 | 81.23 | 81.2 | The phosphoinositide 3-kinase pathway. | Lewis C Cantley | Science | 2002 | 12040186 | No |
| 292 | 4093 | 4093.0 | 0.0 | 0.0 | The determination of enzyme inhibitor constants. | M Dixon | Biochem J | 1953 | 13093635 | Yes |
| 293 | 8169 | 4084.5 | 1835.38 | 917.7 | Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. | Zunyou Wu, Jennifer M McGoogan | JAMA | 2020 | 32091533 | Yes |
| 294 | 4078 | 4078.0 | 0.0 | 0.0 | Determination of protein: a modification of the Lowry method that gives a linear photometric response. | E F Hartree | Anal Biochem | 1972 | 4115981 | Yes |
| 295 | 4065 | 4065.0 | 75.61 | 75.6 | Generalized lacZ expression with the ROSA26 Cre reporter strain. | P Soriano | Nat Genet | 1999 | 9916792 | Yes |
| 296 | 4063 | 4063.0 | 88.21 | 88.2 | Wnt/beta-catenin signaling in development and disease. | Hans Clevers | Cell | 2006 | 17081971 | No |
| 297 | 8119 | 4059.5 | 191.92 | 96.0 | MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. | Jürgen Cox, Matthias Mann | Nat Biotechnol | 2008 | 19029910 | Yes |
| 298 | 8092 | 4046.0 | 0.0 | 0.0 | Functional Evaluation: The Barthel Index. | F I Mahoney, D W Barthel | Md State Med J | 1965 | 14258950 | Yes |
| 299 | 4029 | 4029.0 | 0.0 | 0.0 | Bone: formation by autoinduction. | M R Urist | Science | 1965 | 5319761 | Yes |
| 300 | 12032 | 4010.7 | 765.4 | 255.1 | Cancer statistics, 2016. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2016 | 26742998 | Yes |
| 301 | 8011 | 4005.5 | 0.0 | 0.0 | Assessment of older people: self-maintaining and instrumental activities of daily living. | M P Lawton, E M Brody | Gerontologist | 1969 | 5349366 | Yes |
| 302 | 3994 | 3994.0 | 0.0 | 0.0 | Staining of tissue sections for electron microscopy with heavy metals. | M L Watson | J Biophys Biochem Cytol | 1958 | 13563554 | Yes |
| 303 | 3992 | 3992.0 | 126.73 | 126.7 | Bacterial evolution. | C R Woese | Microbiol Rev | 1987 | 2439888 | No |
| 304 | 3989 | 3989.0 | 0.0 | 0.0 | The detection of disease clustering and a generalized regression approach. | N Mantel | Cancer Res | 1967 | 6018555 | Yes |
| 305 | 3972 | 3972.0 | 103.83 | 103.8 | Integrins: a family of cell surface receptors. | R O Hynes | Cell | 1987 | 3028640 | No |
| 306 | 3957 | 3957.0 | 137.47 | 137.5 | Whatever happened to qualitative description? | M Sandelowski | Res Nurs Health | 2000 | 10940958 | No |
| 307 | 3936 | 3936.0 | 91.01 | 91.0 | Tandem repeats finder: a program to analyze DNA sequences. | G Benson | Nucleic Acids Res | 1999 | 9862982 | Yes |
| 308 | 3932 | 3932.0 | 0.0 | 0.0 | Disc Electrophoresis. I. Background And Theory. | L Ornstein | Ann N Y Acad Sci | 1964 | 14240533 | Yes |
| 309 | 3929 | 3929.0 | 130.02 | 130.0 | Updating P300: an integrative theory of P3a and P3b. | John Polich | Clin Neurophysiol | 2007 | 17573239 | No |
| 310 | 7855 | 3927.5 | 0.0 | 0.0 | Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. | H Aviv, P Leder | Proc Natl Acad Sci U S A | 1972 | 4504350 | Yes |
| 311 | 3926 | 3926.0 | 129.0 | 129.0 | Tissue destruction by neutrophils. | S J Weiss | N Engl J Med | 1989 | 2536474 | No |
| 312 | 7837 | 3918.5 | 192.28 | 96.1 | Collective dynamics of 'small-world' networks. | D J Watts, S H Strogatz | Nature | 1998 | 9623998 | Yes |
| 313 | 3906 | 3906.0 | 88.39 | 88.4 | PAML: a program package for phylogenetic analysis by maximum likelihood. | Z Yang | Comput Appl Biosci | 1997 | 9367129 | Yes |
| 314 | 3904 | 3904.0 | 145.59 | 145.6 | EuroQol: the current state of play. | R Brooks | Health Policy | 1996 | 10158943 | No |
| 315 | 3891 | 3891.0 | 107.2 | 107.2 | What is the evidence that tumors are angiogenesis dependent? | J Folkman | J Natl Cancer Inst | 1990 | 1688381 | No |
| 316 | 3891 | 3891.0 | 87.11 | 87.1 | Atherosclerosis. | A J Lusis | Nature | 2000 | 11001066 | No |
| 317 | 3891 | 3891.0 | 0.0 | 0.0 | New methods for calculating metabolic rate with special reference to protein metabolism. | J B De B Weir | J Physiol | 1949 | 15394301 | Yes |
| 318 | 3881 | 3881.0 | 120.57 | 120.6 | Nitric oxide as a secretory product of mammalian cells. | C Nathan | FASEB J | 1992 | 1381691 | No |
| 319 | 15477 | 3869.2 | 440.2 | 110.0 | Features and development of Coot. | P Emsley, B Lohkamp, W G Scott, K Cowtan | Acta Crystallogr D Biol Crystallogr | 2010 | 20383002 | Yes |
| 320 | 7732 | 3866.0 | 228.15 | 114.1 | Estimating F-Statistics For The Analysis Of Population Structure. | B S Weir, C Clark Cockerham | Evolution | 1984 | 28563791 | Yes |
| 321 | 3861 | 3861.0 | 0.0 | 0.0 | Pharmacological implications of microsomal enzyme induction. | A H Conney | Pharmacol Rev | 1967 | 4383307 | Yes |
| 322 | 7709 | 3854.5 | 0.0 | 0.0 | Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. | D E Paglia, W N Valentine | J Lab Clin Med | 1967 | 6066618 | Yes |
| 323 | 7683 | 3841.5 | 300.04 | 150.0 | Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. | Kristopher J Preacher, Andrew F Hayes | Behav Res Methods | 2008 | 18697684 | Yes |
| 324 | 11515 | 3838.3 | 515.02 | 171.7 | Development and validation of brief measures of positive and negative affect: the PANAS scales. | D Watson, L A Clark, A Tellegen | J Pers Soc Psychol | 1988 | 3397865 | Yes |
| 325 | 3824 | 3824.0 | 82.27 | 82.3 | The green fluorescent protein. | R Y Tsien | Annu Rev Biochem | 1998 | 9759496 | No |
| 326 | 22941 | 3823.5 | 767.32 | 127.9 | Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. | D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C Turner | Diabetologia | 1985 | 3899825 | Yes |
| 327 | 3819 | 3819.0 | 95.27 | 95.3 | Why most published research findings are false. | John P A Ioannidis | PLoS Med | 2005 | 16060722 | Yes |
| 328 | 11428 | 3809.3 | 1425.42 | 475.1 | Cancer statistics, 2019. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2019 | 30620402 | Yes |
| 329 | 3783 | 3783.0 | 0.0 | 0.0 | A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. | E Pfeiffer | J Am Geriatr Soc | 1975 | 1159263 | Yes |
| 330 | 11339 | 3779.7 | 0.0 | 0.0 | Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. | W H Habig, M J Pabst, W B Jakoby | J Biol Chem | 1974 | 4436300 | Yes |
| 331 | 3779 | 3779.0 | 81.01 | 81.0 | A catalogue of splice junction sequences. | S M Mount | Nucleic Acids Res | 1982 | 7063411 | Yes |
| 332 | 3777 | 3777.0 | 104.25 | 104.2 | Revisions in the International System for Staging Lung Cancer. | C F Mountain | Chest | 1997 | 9187198 | Yes |
| 333 | 3777 | 3777.0 | 101.58 | 101.6 | Staphylococcus aureus infections. | F D Lowy | N Engl J Med | 1998 | 9709046 | No |
| 334 | 7535 | 3767.5 | 143.37 | 71.7 | A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. | R S Sikorski, P Hieter | Genetics | 1989 | 2659436 | Yes |
| 335 | 3765 | 3765.0 | 0.0 | 0.0 | Preparation of isolated rat liver cells. | P O Seglen | Methods Cell Biol | 1976 | 177845 | No |
| 336 | 3758 | 3758.0 | 0.0 | 0.0 | Estimation of the molecular weights of proteins by Sephadex gel-filtration. | P Andrews | Biochem J | 1964 | 4158310 | Yes |
| 337 | 7514 | 3757.0 | 188.01 | 94.0 | WGCNA: an R package for weighted correlation network analysis. | Peter Langfelder, Steve Horvath | BMC Bioinformatics | 2008 | 19114008 | Yes |
| 338 | 7477 | 3738.5 | 270.82 | 135.4 | Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. | U H Graneheim, B Lundman | Nurse Educ Today | 2004 | 14769454 | No |
| 339 | 11215 | 3738.3 | 0.0 | 0.0 | Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. | J F Kerr, A H Wyllie, A R Currie | Br J Cancer | 1972 | 4561027 | No |
| 340 | 3737 | 3737.0 | 108.14 | 108.1 | Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. | J H Morrissey | Anal Biochem | 1981 | 6172996 | Yes |
| 341 | 3735 | 3735.0 | 92.91 | 92.9 | Multiple sequence alignment with hierarchical clustering. | F Corpet | Nucleic Acids Res | 1988 | 2849754 | Yes |
| 342 | 3735 | 3735.0 | 122.63 | 122.6 | Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. | Ilan H Meyer | Psychol Bull | 2003 | 12956539 | No |
| 343 | 11170 | 3723.3 | 216.02 | 72.0 | Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. | J D Dignam, R M Lebovitz, R G Roeder | Nucleic Acids Res | 1983 | 6828386 | Yes |
| 344 | 3715 | 3715.0 | 0.0 | 0.0 | Evolution in Mendelian Populations. | S Wright | Genetics | 1931 | 17246615 | Yes |
| 345 | 11142 | 3714.0 | 801.06 | 267.0 | Cancer Statistics, 2017. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2017 | 28055103 | Yes |
| 346 | 3704 | 3704.0 | 0.0 | 0.0 | A membrane-filter technique for the detection of complementary DNA. | D T Denhardt | Biochem Biophys Res Commun | 1966 | 5963888 | Yes |
| 347 | 3702 | 3702.0 | 90.1 | 90.1 | Caspases: the executioners of apoptosis. | G M Cohen | Biochem J | 1997 | 9337844 | No |
| 348 | 7384 | 3692.0 | 254.17 | 127.1 | DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. | P Librado, J Rozas | Bioinformatics | 2009 | 19346325 | Yes |
| 349 | 3689 | 3689.0 | 0.0 | 0.0 | Principles that govern the folding of protein chains. | C B Anfinsen | Science | 1973 | 4124164 | Yes |
| 350 | 7365 | 3682.5 | 182.84 | 91.4 | Mitochondria and apoptosis. | D R Green, J C Reed | Science | 1998 | 9721092 | No |
| 351 | 3681 | 3681.0 | 78.12 | 78.1 | TGF-beta signal transduction. | J Massagué | Annu Rev Biochem | 1998 | 9759503 | No |
| 352 | 3679 | 3679.0 | 75.86 | 75.9 | Hypoxia--a key regulatory factor in tumour growth. | Adrian L Harris | Nat Rev Cancer | 2002 | 11902584 | No |
| 353 | 3673 | 3673.0 | 88.87 | 88.9 | Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. | A T Brünger | Nature | 1992 | 18481394 | Yes |
| 354 | 7344 | 3672.0 | 210.41 | 105.2 | Ab initio molecular dynamics for liquid metals. | Kresse, Hafner | Phys Rev B Condens Matter | 1993 | 10004490 | Yes |
| 355 | 10999 | 3666.3 | 999.9 | 333.3 | Cancer statistics, 2018. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2018 | 29313949 | Yes |
| 356 | 7312 | 3656.0 | 0.0 | 0.0 | Radiological assessment of osteo-arthrosis. | J H Kellgren, J S Lawrence | Ann Rheum Dis | 1957 | 13498604 | Yes |
| 357 | 3654 | 3654.0 | 139.81 | 139.8 | Measuring the accuracy of diagnostic systems. | J A Swets | Science | 1988 | 3287615 | No |
| 358 | 3647 | 3647.0 | 0.0 | 0.0 | Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. | J Cohen | Psychol Bull | 1968 | 19673146 | Yes |
| 359 | 14587 | 3646.8 | 395.24 | 98.8 | Global cancer statistics, 2002. | D Max Parkin, Freddie Bray, J Ferlay, Paola Pisani | CA Cancer J Clin | 2005 | 15761078 | Yes |
| 360 | 3642 | 3642.0 | 82.6 | 82.6 | Protein production by auto-induction in high density shaking cultures. | F William Studier | Protein Expr Purif | 2005 | 15915565 | Yes |
| 361 | 3637 | 3637.0 | 77.39 | 77.4 | Protein secondary structure prediction based on position-specific scoring matrices. | D T Jones | J Mol Biol | 1999 | 10493868 | Yes |
| 362 | 10884 | 3628.0 | 417.13 | 139.0 | A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. | J Ware, M Kosinski, S D Keller | Med Care | 1996 | 8628042 | Yes |
| 363 | 7242 | 3621.0 | 308.55 | 154.3 | The timed "Up & Go": a test of basic functional mobility for frail elderly persons. | D Podsiadlo, S Richardson | J Am Geriatr Soc | 1991 | 1991946 | Yes |
| 364 | 7241 | 3620.5 | 0.0 | 0.0 | The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. | R C Graham, M J Karnovsky | J Histochem Cytochem | 1966 | 5962951 | Yes |
| 365 | 3604 | 3604.0 | 109.58 | 109.6 | Inositol trisphosphate and diacylglycerol as second messengers. | M J Berridge | Biochem J | 1984 | 6146314 | No |
| 366 | 3603 | 3603.0 | 0.0 | 0.0 | The Scree Test For The Number Of Factors. | R B Cattell | Multivariate Behav Res | 1966 | 26828106 | Yes |
| 367 | 7187 | 3593.5 | 185.71 | 92.9 | tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. | T M Lowe, S R Eddy | Nucleic Acids Res | 1997 | 9023104 | Yes |
| 368 | 3593 | 3593.0 | 84.75 | 84.8 | Novel proteinaceous infectious particles cause scrapie. | S B Prusiner | Science | 1982 | 6801762 | Yes |
| 369 | 3593 | 3593.0 | 100.77 | 100.8 | Sequencing technologies - the next generation. | Michael L Metzker | Nat Rev Genet | 2010 | 19997069 | No |
| 370 | 3591 | 3591.0 | 66.5 | 66.5 | Somatic generation of antibody diversity. | S Tonegawa | Nature | 1983 | 6300689 | No |
| 371 | 3591 | 3591.0 | 72.25 | 72.2 | Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. | G R Martin | Proc Natl Acad Sci U S A | 1981 | 6950406 | Yes |
| 372 | 3582 | 3582.0 | 121.55 | 121.5 | Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. | Russell A Barkley | Psychol Bull | 1997 | 9000892 | No |
| 373 | 3577 | 3577.0 | 99.45 | 99.5 | Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. | R B D'Agostino | Stat Med | 1998 | 9802183 | Yes |
| 374 | 3576 | 3576.0 | 107.67 | 107.7 | Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. | Vanderbilt | Phys Rev B Condens Matter | 1990 | 9993096 | Yes |
| 375 | 3566 | 3566.0 | 82.62 | 82.6 | Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. | Rakesh K Jain | Science | 2005 | 15637262 | No |
| 376 | 3562 | 3562.0 | 100.22 | 100.2 | Biological roles of oligosaccharides: all of the theories are correct. | A Varki | Glycobiology | 1993 | 8490246 | No |
| 377 | 3527 | 3527.0 | 80.35 | 80.3 | Instability and decay of the primary structure of DNA. | T Lindahl | Nature | 1993 | 8469282 | No |
| 378 | 3517 | 3517.0 | 84.46 | 84.5 | Marrow stromal cells as stem cells for nonhematopoietic tissues. | D J Prockop | Science | 1997 | 9082988 | No |
| 379 | 7014 | 3507.0 | 158.02 | 79.0 | Functional rafts in cell membranes. | K Simons, E Ikonen | Nature | 1997 | 9177342 | No |
| 380 | 7008 | 3504.0 | 132.52 | 66.3 | Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. | A H Brand, N Perrimon | Development | 1993 | 8223268 | Yes |
| 381 | 7002 | 3501.0 | 266.48 | 133.2 | The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. | I F Benzie, J J Strain | Anal Biochem | 1996 | 8660627 | Yes |
| 382 | 3490 | 3490.0 | 0.0 | 0.0 | Statistical estimations in enzyme kinetics. | G N Wilkinson | Biochem J | 1961 | 13785321 | Yes |
| 383 | 3487 | 3487.0 | 0.0 | 0.0 | Generalized expectancies for internal versus external control of reinforcement. | J B Rotter | Psychol Monogr | 1966 | 5340840 | No |
| 384 | 6972 | 3486.0 | 0.0 | 0.0 | A new method for sequencing DNA. | A M Maxam, W Gilbert | Proc Natl Acad Sci U S A | 1977 | 265521 | Yes |
| 385 | 6968 | 3484.0 | 183.92 | 92.0 | Control of goal-directed and stimulus-driven attention in the brain. | Maurizio Corbetta, Gordon L Shulman | Nat Rev Neurosci | 2002 | 11994752 | No |
| 386 | 3481 | 3481.0 | 119.8 | 119.8 | How do you feel--now? The anterior insula and human awareness. | A D Bud Craig | Nat Rev Neurosci | 2009 | 19096369 | No |
| 387 | 3478 | 3478.0 | 0.0 | 0.0 | Basic principles of ROC analysis. | C E Metz | Semin Nucl Med | 1978 | 112681 | Yes |
| 388 | 17388 | 3477.6 | 504.93 | 101.0 | Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. | O P Hamill, A Marty, E Neher, B Sakmann, F J Sigworth | Pflugers Arch | 1981 | 6270629 | Yes |
| 389 | 3470 | 3470.0 | 0.0 | 0.0 | Spectroscopic determination of tryptophan and tyrosine in proteins. | H Edelhoch | Biochemistry | 1967 | 6049437 | Yes |
| 390 | 13870 | 3467.5 | 568.99 | 142.2 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | Ann Intern Med | 2009 | 19622511 | No |
| 391 | 6933 | 3466.5 | 206.91 | 103.5 | BEAST: Bayesian evolutionary analysis by sampling trees. | Alexei J Drummond, Andrew Rambaut | BMC Evol Biol | 2007 | 17996036 | Yes |
| 392 | 3449 | 3449.0 | 71.35 | 71.3 | Mammalian neural stem cells. | F H Gage | Science | 2000 | 10688783 | No |
| 393 | 6884 | 3442.0 | 164.67 | 82.3 | "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. | A P Feinberg, B Vogelstein | Anal Biochem | 1984 | 6329026 | Yes |
| 394 | 3439 | 3439.0 | 77.86 | 77.9 | Scaling and assessment of data quality. | Philip Evans | Acta Crystallogr D Biol Crystallogr | 2006 | 16369096 | No |
| 395 | 3438 | 3438.0 | 102.77 | 102.8 | What's wrong with Bonferroni adjustments. | T V Perneger | BMJ | 1998 | 9553006 | No |
| 396 | 3428 | 3428.0 | 115.62 | 115.6 | genepop'007: a complete re-implementation of the genepop software for Windows and Linux. | François Rousset | Mol Ecol Resour | 2008 | 21585727 | Yes |
| 397 | 10230 | 3410.0 | 421.34 | 140.4 | A global measure of perceived stress. | S Cohen, T Kamarck, R Mermelstein | J Health Soc Behav | 1983 | 6668417 | Yes |
| 398 | 3408 | 3408.0 | 0.0 | 0.0 | The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. | J F Woessner | Arch Biochem Biophys | 1961 | 13786180 | Yes |
| 399 | 3402 | 3402.0 | 101.86 | 101.9 | Protective and damaging effects of stress mediators. | B S McEwen | N Engl J Med | 1998 | 9428819 | No |
| 400 | 3393 | 3393.0 | 0.0 | 0.0 | Observational study of behavior: sampling methods. | J Altmann | Behaviour | 1974 | 4597405 | No |
| 401 | 3392 | 3392.0 | 183.07 | 183.1 | Executive functions. | Adele Diamond | Annu Rev Psychol | 2013 | 23020641 | No |
| 402 | 3391 | 3391.0 | 132.55 | 132.6 | A concordance correlation coefficient to evaluate reproducibility. | L I Lin | Biometrics | 1989 | 2720055 | Yes |
| 403 | 3388 | 3388.0 | 91.61 | 91.6 | Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? | Kim A Brogden | Nat Rev Microbiol | 2005 | 15703760 | No |
| 404 | 3383 | 3383.0 | 84.52 | 84.5 | The heat-shock response. | S Lindquist | Annu Rev Biochem | 1986 | 2427013 | No |
| 405 | 3382 | 3382.0 | 103.32 | 103.3 | Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. | L R Squire | Psychol Rev | 1992 | 1594723 | No |
| 406 | 10141 | 3380.3 | 0.0 | 0.0 | The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. | F C Greenwood, W M Hunter, J S Glover | Biochem J | 1963 | 14097352 | Yes |
| 407 | 3380 | 3380.0 | 89.46 | 89.5 | Microglia: a sensor for pathological events in the CNS. | G W Kreutzberg | Trends Neurosci | 1996 | 8843599 | No |
| 408 | 10118 | 3372.7 | 443.73 | 147.9 | Cancer statistics, 2013. | Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal | CA Cancer J Clin | 2013 | 23335087 | Yes |
| 409 | 3369 | 3369.0 | 88.35 | 88.3 | Oxidative stress, antioxidants and stress tolerance. | Ron Mittler | Trends Plant Sci | 2002 | 12234732 | No |
| 410 | 3366 | 3366.0 | 0.0 | 0.0 | Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. | J D Rowley | Nature | 1973 | 4126434 | Yes |
| 411 | 10096 | 3365.3 | 332.62 | 110.9 | Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. | E R DeLong, D M DeLong, D L Clarke-Pearson | Biometrics | 1988 | 3203132 | Yes |
| 412 | 3364 | 3364.0 | 79.4 | 79.4 | The dendritic cell system and its role in immunogenicity. | R M Steinman | Annu Rev Immunol | 1991 | 1910679 | No |
| 413 | 6718 | 3359.0 | 173.98 | 87.0 | TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. | T R Mosmann, R L Coffman | Annu Rev Immunol | 1989 | 2523712 | No |
| 414 | 3359 | 3359.0 | 65.86 | 65.9 | Signal transduction by the JNK group of MAP kinases. | R J Davis | Cell | 2000 | 11057897 | No |
| 415 | 3341 | 3341.0 | 90.0 | 90.0 | The adolescent brain and age-related behavioral manifestations. | L P Spear | Neurosci Biobehav Rev | 2000 | 10817843 | No |
| 416 | 3329 | 3329.0 | 93.01 | 93.0 | Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. | R W Mahley | Science | 1988 | 3283935 | No |
| 417 | 3329 | 3329.0 | 69.14 | 69.1 | Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. | M Kozak | Nucleic Acids Res | 1984 | 6694911 | Yes |
| 418 | 6651 | 3325.5 | 125.04 | 62.5 | Translating the histone code. | T Jenuwein, C D Allis | Science | 2001 | 11498575 | No |
| 419 | 3319 | 3319.0 | 68.98 | 69.0 | The scanning model for translation: an update. | M Kozak | J Cell Biol | 1989 | 2645293 | No |
| 420 | 3315 | 3315.0 | 0.0 | 0.0 | Some factors in the interpretation of protein denaturation. | W Kauzmann | Adv Protein Chem | 1959 | 14404936 | Yes |
| 421 | 3314 | 3314.0 | 0.0 | 0.0 | Equilibrium Ultracentrifugation Of Dilute Solutions. | D A Yphantis | Biochemistry | 1964 | 14155091 | Yes |
| 422 | 3310 | 3310.0 | 84.8 | 84.8 | Gene regulation by steroid hormones. | M Beato | Cell | 1989 | 2644044 | No |
| 423 | 9925 | 3308.3 | 402.71 | 134.2 | Cancer statistics, 2012. | Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal | CA Cancer J Clin | 2012 | 22237781 | Yes |
| 424 | 19840 | 3306.7 | 1123.85 | 187.3 | Global cancer statistics, 2012. | Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin Jemal | CA Cancer J Clin | 2015 | 25651787 | Yes |
| 425 | 13214 | 3303.5 | 336.19 | 84.0 | Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. | Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg | Genome Biol | 2009 | 19261174 | Yes |
| 426 | 3302 | 3302.0 | 86.26 | 86.3 | I-TASSER server for protein 3D structure prediction. | Yang Zhang | BMC Bioinformatics | 2008 | 18215316 | Yes |
| 427 | 3296 | 3296.0 | 131.79 | 131.8 | Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. | O W Griffith | Anal Biochem | 1980 | 7416462 | Yes |
| 428 | 6592 | 3296.0 | 0.0 | 0.0 | Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. | D H Hubel, T N Wiesel | J Physiol | 1962 | 14449617 | Yes |
| 429 | 3290 | 3290.0 | 88.42 | 88.4 | The origins and the future of microfluidics. | George M Whitesides | Nature | 2006 | 16871203 | No |
| 430 | 3289 | 3289.0 | 78.25 | 78.2 | Nonalcoholic fatty liver disease. | Paul Angulo | N Engl J Med | 2002 | 11961152 | No |
| 431 | 6571 | 3285.5 | 170.6 | 85.3 | An integrative theory of prefrontal cortex function. | E K Miller, J D Cohen | Annu Rev Neurosci | 2001 | 11283309 | No |
| 432 | 3285 | 3285.0 | 78.24 | 78.2 | Glutamate uptake. | N C Danbolt | Prog Neurobiol | 2001 | 11369436 | No |
| 433 | 3281 | 3281.0 | 84.63 | 84.6 | Biologic basis for interleukin-1 in disease. | C A Dinarello | Blood | 1996 | 8630372 | No |
| 434 | 9838 | 3279.3 | 539.11 | 179.7 | Cancer statistics, 2015. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2015 | 25559415 | Yes |
| 435 | 3274 | 3274.0 | 0.0 | 0.0 | Estimation of average heterozygosity and genetic distance from a small number of individuals. | M Nei | Genetics | 1978 | 17248844 | Yes |
| 436 | 13061 | 3265.2 | 305.48 | 76.4 | Improved methods for building protein models in electron density maps and the location of errors in these models. | T A Jones, J Y Zou, S W Cowan, M Kjeldgaard | Acta Crystallogr A | 1991 | 2025413 | Yes |
| 437 | 3264 | 3264.0 | 70.07 | 70.1 | Profile hidden Markov models. | S R Eddy | Bioinformatics | 1998 | 9918945 | No |
| 438 | 3263 | 3263.0 | 76.31 | 76.3 | Folding DNA to create nanoscale shapes and patterns. | Paul W K Rothemund | Nature | 2006 | 16541064 | Yes |
| 439 | 22662 | 3237.4 | 524.71 | 75.0 | UCSF Chimera--a visualization system for exploratory research and analysis. | Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin | J Comput Chem | 2004 | 15264254 | Yes |
| 440 | 3237 | 3237.0 | 101.04 | 101.0 | Graphene: status and prospects. | A K Geim | Science | 2009 | 19541989 | Yes |
| 441 | 6471 | 3235.5 | 0.0 | 0.0 | Microsomal lipid peroxidation. | J A Buege, S D Aust | Methods Enzymol | 1978 | 672633 | Yes |
| 442 | 3226 | 3226.0 | 93.23 | 93.2 | Inositol trisphosphate and diacylglycerol: two interacting second messengers. | M J Berridge | Annu Rev Biochem | 1987 | 3304132 | No |
| 443 | 3226 | 3226.0 | 106.92 | 106.9 | Modeling valuations for EuroQol health states. | P Dolan | Med Care | 1997 | 9366889 | Yes |
| 444 | 6418 | 3209.0 | 176.4 | 88.2 | The basics of epithelial-mesenchymal transition. | Raghu Kalluri, Robert A Weinberg | J Clin Invest | 2009 | 19487818 | No |
| 445 | 3207 | 3207.0 | 75.07 | 75.1 | Tolerance, danger, and the extended family. | P Matzinger | Annu Rev Immunol | 1994 | 8011301 | No |
| 446 | 3190 | 3190.0 | 103.19 | 103.2 | Emerging adulthood. A theory of development from the late teens through the twenties. | J J Arnett | Am Psychol | 2000 | 10842426 | Yes |
| 447 | 3189 | 3189.0 | 71.51 | 71.5 | Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. | H F Dvorak | N Engl J Med | 1986 | 3537791 | No |
| 448 | 3189 | 3189.0 | 93.68 | 93.7 | Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. | Thomas Welton | Chem Rev | 1999 | 11849019 | Yes |
| 449 | 3184 | 3184.0 | 0.0 | 0.0 | The magical number seven plus or minus two: some limits on our capacity for processing information. | G A Miller | Psychol Rev | 1956 | 13310704 | Yes |
| 450 | 3181 | 3181.0 | 79.42 | 79.4 | The transforming growth factor-beta family. | J Massagué | Annu Rev Cell Biol | 1990 | 2177343 | No |
| 451 | 9540 | 3180.0 | 363.25 | 121.1 | Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. | Allison Tong, Peter Sainsbury, Jonathan Craig | Int J Qual Health Care | 2007 | 17872937 | Yes |
| 452 | 3176 | 3176.0 | 85.93 | 85.9 | ABC transporters: from microorganisms to man. | C F Higgins | Annu Rev Cell Biol | 1992 | 1282354 | No |
| 453 | 6332 | 3166.0 | 238.3 | 119.2 | Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. | Laurent Excoffier, Heidi E L Lischer | Mol Ecol Resour | 2010 | 21565059 | Yes |
| 454 | 18995 | 3165.8 | 737.56 | 122.9 | Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. | Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G Conde | J Biomed Inform | 2009 | 18929686 | Yes |
| 455 | 6331 | 3165.5 | 186.78 | 93.4 | Velvet: algorithms for de novo short read assembly using de Bruijn graphs. | Daniel R Zerbino, Ewan Birney | Genome Res | 2008 | 18349386 | Yes |
| 456 | 3165 | 3165.0 | 101.59 | 101.6 | Functions of DNA methylation: islands, start sites, gene bodies and beyond. | Peter A Jones | Nat Rev Genet | 2012 | 22641018 | No |
| 457 | 3153 | 3153.0 | 0.0 | 0.0 | Diffusion-in-gel methods for immunological analysis. | O Ouchterlony | Prog Allergy | 1958 | 13578996 | Yes |
| 458 | 3138 | 3138.0 | 0.0 | 0.0 | Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. | S W Kessler | J Immunol | 1975 | 1102604 | Yes |
| 459 | 6273 | 3136.5 | 130.61 | 65.3 | Statistical significance for genomewide studies. | John D Storey, Robert Tibshirani | Proc Natl Acad Sci U S A | 2003 | 12883005 | Yes |
| 460 | 9395 | 3131.7 | 416.46 | 138.8 | HTSeq--a Python framework to work with high-throughput sequencing data. | Simon Anders, Paul Theodor Pyl, Wolfgang Huber | Bioinformatics | 2015 | 25260700 | Yes |
| 461 | 6258 | 3129.0 | 123.42 | 61.7 | The ubiquitin system. | A Hershko, A Ciechanover | Annu Rev Biochem | 1998 | 9759494 | No |
| 462 | 3124 | 3124.0 | 64.9 | 64.9 | CpG-rich islands and the function of DNA methylation. | A P Bird | Nature | 1986 | 2423876 | No |
| 463 | 6247 | 3123.5 | 149.59 | 74.8 | Inference of macromolecular assemblies from crystalline state. | Evgeny Krissinel, Kim Henrick | J Mol Biol | 2007 | 17681537 | Yes |
| 464 | 3123 | 3123.0 | 90.02 | 90.0 | EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. | W Klimesch | Brain Res Brain Res Rev | 1999 | 10209231 | No |
| 465 | 3113 | 3113.0 | 62.84 | 62.8 | STATs and gene regulation. | J E Darnell | Science | 1997 | 9287210 | No |
| 466 | 3113 | 3113.0 | 68.82 | 68.8 | Activators and target genes of Rel/NF-kappaB transcription factors. | H L Pahl | Oncogene | 1999 | 10602461 | No |
| 467 | 3112 | 3112.0 | 59.19 | 59.2 | Cell signaling by receptor tyrosine kinases. | J Schlessinger | Cell | 2000 | 11057895 | No |
| 468 | 6222 | 3111.0 | 0.0 | 0.0 | Human malaria parasites in continuous culture. | W Trager, J B Jensen | Science | 1976 | 781840 | Yes |
| 469 | 3111 | 3111.0 | 76.81 | 76.8 | Neural networks and physical systems with emergent collective computational abilities. | J J Hopfield | Proc Natl Acad Sci U S A | 1982 | 6953413 | Yes |
| 470 | 6216 | 3108.0 | 180.13 | 90.1 | Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. | S Duval, R Tweedie | Biometrics | 2000 | 10877304 | Yes |
| 471 | 6209 | 3104.5 | 138.17 | 69.1 | Angiogenesis in cancer and other diseases. | P Carmeliet, R K Jain | Nature | 2000 | 11001068 | No |
| 472 | 12360 | 3090.0 | 494.3 | 123.6 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | BMJ | 2009 | 19622551 | No |
| 473 | 3087 | 3087.0 | 80.91 | 80.9 | The pathobiology of diabetic complications: a unifying mechanism. | Michael Brownlee | Diabetes | 2005 | 15919781 | No |
| 474 | 3085 | 3085.0 | 73.4 | 73.4 | WHAT IF: a molecular modeling and drug design program. | G Vriend | J Mol Graph | 1990 | 2268628 | Yes |
| 475 | 3070 | 3070.0 | 75.94 | 75.9 | Wound healing--aiming for perfect skin regeneration. | P Martin | Science | 1997 | 9082989 | No |
| 476 | 3070 | 3070.0 | 76.55 | 76.5 | Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. | Ting-Chao Chou | Pharmacol Rev | 2006 | 16968952 | No |
| 477 | 3063 | 3063.0 | 77.56 | 77.6 | The basis of anisotropic water diffusion in the nervous system - a technical review. | Christian Beaulieu | NMR Biomed | 2002 | 12489094 | No |
| 478 | 9173 | 3057.7 | 241.15 | 80.4 | Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nucleic Acids Res | 2009 | 19033363 | Yes |
| 479 | 3056 | 3056.0 | 75.08 | 75.1 | Photoelectrochemical cells. | M Grätzel | Nature | 2001 | 11713540 | Yes |
| 480 | 9157 | 3052.3 | 313.41 | 104.5 | Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. | R M Palmer, A G Ferrige, S Moncada | Nature | 1987 | 3495737 | Yes |
| 481 | 3051 | 3051.0 | 84.82 | 84.8 | Hay fever, hygiene, and household size. | D P Strachan | BMJ | 1989 | 2513902 | Yes |
| 482 | 3049 | 3049.0 | 78.45 | 78.5 | How do you feel? Interoception: the sense of the physiological condition of the body. | A D Craig | Nat Rev Neurosci | 2002 | 12154366 | No |
| 483 | 6087 | 3043.5 | 153.73 | 76.9 | The plant immune system. | Jonathan D G Jones, Jeffery L Dangl | Nature | 2006 | 17108957 | No |
| 484 | 3037 | 3037.0 | 83.27 | 83.3 | Mesenchymal stem cells. | A I Caplan | J Orthop Res | 1991 | 1870029 | Yes |
| 485 | 3033 | 3033.0 | 88.82 | 88.8 | Drug combination studies and their synergy quantification using the Chou-Talalay method. | Ting-Chao Chou | Cancer Res | 2010 | 20068163 | Yes |
| 486 | 9092 | 3030.7 | 1926.54 | 642.2 | Cancer statistics, 2020. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2020 | 31912902 | Yes |
| 487 | 3007 | 3007.0 | 70.77 | 70.8 | Cadherin cell adhesion receptors as a morphogenetic regulator. | M Takeichi | Science | 1991 | 2006419 | No |
| 488 | 3003 | 3003.0 | 62.26 | 62.3 | The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. | Isaiah J Fidler | Nat Rev Cancer | 2003 | 12778135 | No |
| 489 | 3001 | 3001.0 | 0.0 | 0.0 | A study of fixation for electron microscopy. | G E Palade | J Exp Med | 1952 | 14927794 | Yes |
| 490 | 3001 | 3001.0 | 79.66 | 79.7 | Origin and physiological roles of inflammation. | Ruslan Medzhitov | Nature | 2008 | 18650913 | No |
| 491 | 2998 | 2998.0 | 125.29 | 125.3 | FreeSurfer. | Bruce Fischl | Neuroimage | 2012 | 22248573 | No |
| 492 | 5990 | 2995.0 | 226.17 | 113.1 | Management of hepatocellular carcinoma: an update. | Jordi Bruix, Morris Sherman | Hepatology | 2011 | 21374666 | No |
| 493 | 2990 | 2990.0 | 0.0 | 0.0 | Gene action in the X-chromosome of the mouse (Mus musculus L.). | M F Lyon | Nature | 1961 | 13764598 | Yes |
| 494 | 2988 | 2988.0 | 0.0 | 0.0 | Towards a network theory of the immune system. | N K Jerne | Ann Immunol (Paris) | 1974 | 4142565 | No |
| 495 | 5974 | 2987.0 | 144.32 | 72.2 | Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. | C Tuerk, L Gold | Science | 1990 | 2200121 | Yes |
| 496 | 2978 | 2978.0 | 0.0 | 0.0 | Transformed up-down methods in psychoacoustics. | H Levitt | J Acoust Soc Am | 1971 | 5541744 | Yes |
| 497 | 2977 | 2977.0 | 0.0 | 0.0 | A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. | S Hakomori | J Biochem | 1964 | 14135466 | Yes |
| 498 | 2975 | 2975.0 | 0.0 | 0.0 | The gel-filtration behaviour of proteins related to their molecular weights over a wide range. | P Andrews | Biochem J | 1965 | 5862401 | Yes |
| 499 | 2974 | 2974.0 | 65.37 | 65.4 | Mechanisms of angiogenesis and arteriogenesis. | P Carmeliet | Nat Med | 2000 | 10742145 | No |
| 500 | 5926 | 2963.0 | 531.11 | 265.6 | A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. | Terry K Koo, Mae Y Li | J Chiropr Med | 2016 | 27330520 | Yes |
| 501 | 5923 | 2961.5 | 125.89 | 62.9 | Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. | D B Smith, K S Johnson | Gene | 1988 | 3047011 | Yes |
| 502 | 2959 | 2959.0 | 63.34 | 63.3 | Alzheimer's disease is a synaptic failure. | Dennis J Selkoe | Science | 2002 | 12399581 | No |
| 503 | 2953 | 2953.0 | 92.2 | 92.2 | Development of a classification system for periodontal diseases and conditions. | G C Armitage | Ann Periodontol | 1999 | 10863370 | No |
| 504 | 2949 | 2949.0 | 95.92 | 95.9 | Health promotion by social cognitive means. | Albert Bandura | Health Educ Behav | 2004 | 15090118 | Yes |
| 505 | 2948 | 2948.0 | 64.5 | 64.5 | Protein folding and misfolding. | Christopher M Dobson | Nature | 2003 | 14685248 | No |
| 506 | 5895 | 2947.5 | 130.77 | 65.4 | Toll-like receptor signalling. | Shizuo Akira, Kiyoshi Takeda | Nat Rev Immunol | 2004 | 15229469 | No |
| 507 | 5894 | 2947.0 | 0.0 | 0.0 | Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. | C Beauchamp, I Fridovich | Anal Biochem | 1971 | 4943714 | Yes |
| 508 | 2944 | 2944.0 | 88.91 | 88.9 | Non-coding RNAs in human disease. | Manel Esteller | Nat Rev Genet | 2011 | 22094949 | No |
| 509 | 2942 | 2942.0 | 65.1 | 65.1 | Angiogenesis in health and disease. | Peter Carmeliet | Nat Med | 2003 | 12778163 | No |
| 510 | 2936 | 2936.0 | 0.0 | 0.0 | Catheter replacement of the needle in percutaneous arteriography; a new technique. | S I Seldinger | Acta radiol | 1953 | 13057644 | Yes |
| 511 | 5863 | 2931.5 | 158.68 | 79.3 | Fast and accurate long-read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2010 | 20080505 | Yes |
| 512 | 26375 | 2930.6 | 726.28 | 80.7 | The Sequence Alignment/Map format and SAMtools. | Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin | Bioinformatics | 2009 | 19505943 | Yes |
| 513 | 8782 | 2927.3 | 192.03 | 64.0 | Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. | Benjamin P Lewis, Christopher B Burge, David P Bartel | Cell | 2005 | 15652477 | Yes |
| 514 | 8779 | 2926.3 | 179.86 | 60.0 | Significance analysis of microarrays applied to the ionizing radiation response. | V G Tusher, R Tibshirani, G Chu | Proc Natl Acad Sci U S A | 2001 | 11309499 | Yes |
| 515 | 2920 | 2920.0 | 91.19 | 91.2 | Matrix metalloproteinases and their inhibitors in connective tissue remodeling. | J F Woessner | FASEB J | 1991 | 1850705 | No |
| 516 | 8747 | 2915.7 | 243.67 | 81.2 | Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. | Y Gavrieli, Y Sherman, S A Ben-Sasson | J Cell Biol | 1992 | 1400587 | Yes |
| 517 | 2912 | 2912.0 | 69.52 | 69.5 | Chemokines--chemotactic cytokines that mediate inflammation. | A D Luster | N Engl J Med | 1998 | 9459648 | No |
| 518 | 5823 | 2911.5 | 136.49 | 68.2 | MicroRNA signatures in human cancers. | George A Calin, Carlo M Croce | Nat Rev Cancer | 2006 | 17060945 | No |
| 519 | 2905 | 2905.0 | 113.49 | 113.5 | Half a century of research on the Stroop effect: an integrative review. | C M MacLeod | Psychol Bull | 1991 | 2034749 | No |
| 520 | 2898 | 2898.0 | 94.53 | 94.5 | An empirical correction for absorption anisotropy. | R H Blessing | Acta Crystallogr A | 1995 | 7702794 | Yes |
| 521 | 11578 | 2894.5 | 409.43 | 102.4 | A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. | Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge Krieg | J Chem Phys | 2010 | 20423165 | Yes |
| 522 | 2893 | 2893.0 | 118.96 | 119.0 | Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. | T E Moffitt | Psychol Rev | 1993 | 8255953 | No |
| 523 | 5773 | 2886.5 | 166.82 | 83.4 | Projections of global mortality and burden of disease from 2002 to 2030. | Colin D Mathers, Dejan Loncar | PLoS Med | 2006 | 17132052 | Yes |
| 524 | 2885 | 2885.0 | 71.45 | 71.5 | Phase separation of integral membrane proteins in Triton X-114 solution. | C Bordier | J Biol Chem | 1981 | 6257680 | Yes |
| 525 | 5767 | 2883.5 | 0.0 | 0.0 | Pain mechanisms: a new theory. | R Melzack, P D Wall | Science | 1965 | 5320816 | No |
| 526 | 5766 | 2883.0 | 163.77 | 81.9 | Inositol trisphosphate, a novel second messenger in cellular signal transduction. | M J Berridge, R F Irvine | Nature | 1984 | 6095092 | No |
| 527 | 8627 | 2875.7 | 0.0 | 0.0 | The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. | R J Havel, H A Eder, J H Bragdon | J Clin Invest | 1955 | 13252080 | Yes |
| 528 | 11493 | 2873.2 | 456.51 | 114.1 | APACHE II: a severity of disease classification system. | W A Knaus, E A Draper, D P Wagner, J E Zimmerman | Crit Care Med | 1985 | 3928249 | Yes |
| 529 | 2873 | 2873.0 | 51.53 | 51.5 | One-step gene disruption in yeast. | R J Rothstein | Methods Enzymol | 1983 | 6310324 | Yes |
| 530 | 5745 | 2872.5 | 104.98 | 52.5 | The language of covalent histone modifications. | B D Strahl, C D Allis | Nature | 2000 | 10638745 | Yes |
| 531 | 14353 | 2870.6 | 575.4 | 115.1 | The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. | D J Buysse, C F Reynolds, T H Monk, S R Berman, D J Kupfer | Psychiatry Res | 1989 | 2748771 | Yes |
| 532 | 2870 | 2870.0 | 70.18 | 70.2 | Obesity as a medical problem. | P G Kopelman | Nature | 2000 | 10766250 | No |
| 533 | 2866 | 2866.0 | 131.9 | 131.9 | The quality of care. How can it be assessed? | A Donabedian | JAMA | 1988 | 3045356 | No |
| 534 | 2865 | 2865.0 | 0.0 | 0.0 | Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. | L Svennerholm | Biochim Biophys Acta | 1957 | 13436486 | Yes |
| 535 | 2863 | 2863.0 | 0.0 | 0.0 | Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. | B E Murphy | J Clin Endocrinol Metab | 1967 | 4291524 | Yes |
| 536 | 2858 | 2858.0 | 0.0 | 0.0 | Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. | W C Schneider | J Biol Chem | 1945 | 21005736 | Yes |
| 537 | 2857 | 2857.0 | 54.97 | 55.0 | RNA interference. | Gregory J Hannon | Nature | 2002 | 12110901 | No |
| 538 | 2857 | 2857.0 | 93.69 | 93.7 | Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. | Sarah E Barlow | Pediatrics | 2007 | 18055651 | Yes |
| 539 | 5706 | 2853.0 | 149.16 | 74.6 | Voxel-based morphometry--the methods. | J Ashburner, K J Friston | Neuroimage | 2000 | 10860804 | No |
| 540 | 2852 | 2852.0 | 92.12 | 92.1 | Hepatocellular carcinoma. | Hashem B El-Serag | N Engl J Med | 2011 | 21992124 | No |
| 541 | 8551 | 2850.3 | 0.0 | 0.0 | Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. | G Fairbanks, T L Steck, D F Wallach | Biochemistry | 1971 | 4326772 | Yes |
| 542 | 5692 | 2846.0 | 0.0 | 0.0 | Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. | J Glowinski, L L Iversen | J Neurochem | 1966 | 5950056 | Yes |
| 543 | 2845 | 2845.0 | 59.93 | 59.9 | Principles of CDK regulation. | D O Morgan | Nature | 1995 | 7877684 | No |
| 544 | 5688 | 2844.0 | 0.0 | 0.0 | Assessment of outcome after severe brain damage. | B Jennett, M Bond | Lancet | 1975 | 46957 | Yes |
| 545 | 2844 | 2844.0 | 62.46 | 62.5 | Cardiac excitation-contraction coupling. | Donald M Bers | Nature | 2002 | 11805843 | No |
| 546 | 5686 | 2843.0 | 0.0 | 0.0 | A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. | S Reitman, S Frankel | Am J Clin Pathol | 1957 | 13458125 | Yes |
| 547 | 11370 | 2842.5 | 281.7 | 70.4 | Haploview: analysis and visualization of LD and haplotype maps. | J C Barrett, B Fry, J Maller, M J Daly | Bioinformatics | 2005 | 15297300 | Yes |
| 548 | 2842 | 2842.0 | 0.0 | 0.0 | Notes on sugar determination. | M Smogyi | J Biol Chem | 1952 | 14938350 | Yes |
| 549 | 2833 | 2833.0 | 91.08 | 91.1 | Psychometric properties of the strengths and difficulties questionnaire. | R Goodman | J Am Acad Child Adolesc Psychiatry | 2001 | 11699809 | Yes |
| 550 | 2832 | 2832.0 | 0.0 | 0.0 | A study of the adrenotropic receptors. | R P Ahlquist | Am J Physiol | 1948 | 18882199 | Yes |
| 551 | 2825 | 2825.0 | 99.02 | 99.0 | The processing-speed theory of adult age differences in cognition. | T A Salthouse | Psychol Rev | 1996 | 8759042 | No |
| 552 | 8471 | 2823.7 | 229.62 | 76.5 | Understanding the Warburg effect: the metabolic requirements of cell proliferation. | Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson | Science | 2009 | 19460998 | No |
| 553 | 2820 | 2820.0 | 0.0 | 0.0 | A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. | E A Gehan | Biometrika | 1965 | 14341275 | Yes |
| 554 | 2815 | 2815.0 | 0.0 | 0.0 | Measurement of pain. | E C Huskisson | Lancet | 1974 | 4139420 | Yes |
| 555 | 2815 | 2815.0 | 67.12 | 67.1 | Mitochondrial formation of reactive oxygen species. | Julio F Turrens | J Physiol | 2003 | 14561818 | No |
| 556 | 5624 | 2812.0 | 0.0 | 0.0 | The fluid mosaic model of the structure of cell membranes. | S J Singer, G L Nicolson | Science | 1972 | 4333397 | Yes |
| 557 | 2810 | 2810.0 | 73.87 | 73.9 | Recent advances with liposomes as pharmaceutical carriers. | Vladimir P Torchilin | Nat Rev Drug Discov | 2005 | 15688077 | No |
| 558 | 5615 | 2807.5 | 0.0 | 0.0 | The serial cultivation of human diploid cell strains. | L Hayflick, P S Moorhead | Exp Cell Res | 1961 | 13905658 | Yes |
| 559 | 2807 | 2807.0 | 94.46 | 94.5 | Role of oxidative stress in development of complications in diabetes. | J W Baynes | Diabetes | 1991 | 2010041 | No |
| 560 | 5595 | 2797.5 | 153.95 | 77.0 | The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. | J Vieira, J Messing | Gene | 1982 | 6295879 | Yes |
| 561 | 5586 | 2793.0 | 135.34 | 67.7 | Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. | T C Chou, P Talalay | Adv Enzyme Regul | 1984 | 6382953 | Yes |
| 562 | 11150 | 2787.5 | 0.0 | 0.0 | Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. | P W Rigby, M Dieckmann, C Rhodes, P Berg | J Mol Biol | 1977 | 881736 | Yes |
| 563 | 5575 | 2787.5 | 0.0 | 0.0 | A method for determining the sedimentation behavior of enzymes: application to protein mixtures. | R G Martin, B N Ames | J Biol Chem | 1961 | 13767412 | Yes |
| 564 | 2785 | 2785.0 | 57.56 | 57.6 | Toll-like receptors and innate immunity. | R Medzhitov | Nat Rev Immunol | 2001 | 11905821 | No |
| 565 | 2781 | 2781.0 | 84.79 | 84.8 | Implications of normal brain development for the pathogenesis of schizophrenia. | D R Weinberger | Arch Gen Psychiatry | 1987 | 3606332 | Yes |
| 566 | 2775 | 2775.0 | 0.0 | 0.0 | Efficient trace-labelling of proteins with iodine. | A S McFARLANE | Nature | 1958 | 13566175 | Yes |
| 567 | 5547 | 2773.5 | 137.7 | 68.8 | In vitro selection of RNA molecules that bind specific ligands. | A D Ellington, J W Szostak | Nature | 1990 | 1697402 | Yes |
| 568 | 5543 | 2771.5 | 110.25 | 55.1 | High-efficiency transformation of mammalian cells by plasmid DNA. | C Chen, H Okayama | Mol Cell Biol | 1987 | 3670292 | Yes |
| 569 | 5534 | 2767.0 | 187.97 | 94.0 | Measuring agreement in method comparison studies. | J M Bland, D G Altman | Stat Methods Med Res | 1999 | 10501650 | No |
| 570 | 5521 | 2760.5 | 245.11 | 122.6 | Revised methods for the Salmonella mutagenicity test. | D M Maron, B N Ames | Mutat Res | 1983 | 6341825 | Yes |
| 571 | 2755 | 2755.0 | 71.91 | 71.9 | Optimal two-stage designs for phase II clinical trials. | R Simon | Control Clin Trials | 1989 | 2702835 | Yes |
| 572 | 2755 | 2755.0 | 78.86 | 78.9 | Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. | Y X Fu | Genetics | 1997 | 9335623 | Yes |
| 573 | 2755 | 2755.0 | 53.56 | 53.6 | Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. | P Schuck | Biophys J | 2000 | 10692345 | Yes |
| 574 | 8255 | 2751.7 | 207.18 | 69.1 | TopHat: discovering splice junctions with RNA-Seq. | Cole Trapnell, Lior Pachter, Steven L Salzberg | Bioinformatics | 2009 | 19289445 | Yes |
| 575 | 8254 | 2751.3 | 179.38 | 59.8 | Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. | C M Gorman, L F Moffat, B H Howard | Mol Cell Biol | 1982 | 6960240 | Yes |
| 576 | 5502 | 2751.0 | 128.15 | 64.1 | Caspases: enemies within. | N A Thornberry, Y Lazebnik | Science | 1998 | 9721091 | No |
| 577 | 5500 | 2750.0 | 178.13 | 89.1 | Tissue engineering. | R Langer, J P Vacanti | Science | 1993 | 8493529 | No |
| 578 | 2749 | 2749.0 | 61.17 | 61.2 | Inflammatory bowel disease. | Daniel K Podolsky | N Engl J Med | 2002 | 12167685 | No |
| 579 | 2747 | 2747.0 | 66.07 | 66.1 | Structure and function of telomeres. | E H Blackburn | Nature | 1991 | 1708110 | No |
| 580 | 2744 | 2744.0 | 127.79 | 127.8 | The short-form McGill Pain Questionnaire. | Ronald Melzack | Pain | 1987 | 3670870 | Yes |
| 581 | 2738 | 2738.0 | 140.63 | 140.6 | Interrater reliability: the kappa statistic. | Mary L McHugh | Biochem Med (Zagreb) | 2012 | 23092060 | Yes |
| 582 | 2737 | 2737.0 | 0.0 | 0.0 | Stereotaxic mapping of the monoamine pathways in the rat brain. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4109331 | Yes |
| 583 | 5474 | 2737.0 | 127.45 | 63.7 | Oxidants, oxidative stress and the biology of ageing. | T Finkel, N J Holbrook | Nature | 2000 | 11089981 | No |
| 584 | 2732 | 2732.0 | 0.0 | 0.0 | Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. | P Mitchell | Nature | 1961 | 13771349 | Yes |
| 585 | 5464 | 2732.0 | 127.03 | 63.5 | Oncomirs - microRNAs with a role in cancer. | Aurora Esquela-Kerscher, Frank J Slack | Nat Rev Cancer | 2006 | 16557279 | No |
| 586 | 2730 | 2730.0 | 92.84 | 92.8 | Essential oils: their antibacterial properties and potential applications in foods--a review. | Sara Burt | Int J Food Microbiol | 2004 | 15246235 | No |
| 587 | 2729 | 2729.0 | 66.67 | 66.7 | Cell death during development of the nervous system. | R W Oppenheim | Annu Rev Neurosci | 1991 | 2031577 | No |
| 588 | 2728 | 2728.0 | 52.47 | 52.5 | Genome maintenance mechanisms for preventing cancer. | J H Hoeijmakers | Nature | 2001 | 11357144 | No |
| 589 | 2726 | 2726.0 | 63.15 | 63.1 | TGFbeta in Cancer. | Joan Massagué | Cell | 2008 | 18662538 | No |
| 590 | 10898 | 2724.5 | 365.14 | 91.3 | Cancer statistics, 2010. | Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth Ward | CA Cancer J Clin | 2010 | 20610543 | Yes |
| 591 | 2714 | 2714.0 | 64.38 | 64.4 | Molecular chaperones in cellular protein folding. | F U Hartl | Nature | 1996 | 8637592 | No |
| 592 | 2703 | 2703.0 | 88.23 | 88.2 | No adjustments are needed for multiple comparisons. | K J Rothman | Epidemiology | 1990 | 2081237 | Yes |
| 593 | 8096 | 2698.7 | 209.55 | 69.9 | MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. | Sudhir Kumar, Koichiro Tamura, Masatoshi Nei | Brief Bioinform | 2004 | 15260895 | Yes |
| 594 | 5396 | 2698.0 | 0.0 | 0.0 | A modified uronic acid carbazole reaction. | T Bitter, H M Muir | Anal Biochem | 1962 | 13971270 | Yes |
| 595 | 5396 | 2698.0 | 184.73 | 92.4 | The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. | Stephen B Edge, Carolyn C Compton | Ann Surg Oncol | 2010 | 20180029 | No |
| 596 | 5393 | 2696.5 | 128.69 | 64.3 | Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. | F W Studier, B A Moffatt | J Mol Biol | 1986 | 3537305 | Yes |
| 597 | 2696 | 2696.0 | 0.0 | 0.0 | A gene complex controlling segmentation in Drosophila. | E B Lewis | Nature | 1978 | 103000 | Yes |
| 598 | 8081 | 2693.7 | 270.18 | 90.1 | Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. | R A Deyo, D C Cherkin, M A Ciol | J Clin Epidemiol | 1992 | 1607900 | Yes |
| 599 | 2688 | 2688.0 | 83.61 | 83.6 | Estimation of metabolite concentrations from localized in vivo proton NMR spectra. | S W Provencher | Magn Reson Med | 1993 | 8139448 | Yes |
| 600 | 2685 | 2685.0 | 102.13 | 102.1 | You want to measure coping but your protocol's too long: consider the brief COPE. | C S Carver | Int J Behav Med | 1997 | 16250744 | Yes |
| 601 | 2680 | 2680.0 | 0.0 | 0.0 | The genetical structure of populations. | S Wright | Ann Eugen | 1951 | 24540312 | Yes |
| 602 | 5359 | 2679.5 | 177.43 | 88.7 | mTOR signaling in growth control and disease. | Mathieu Laplante, David M Sabatini | Cell | 2012 | 22500797 | No |
| 603 | 2679 | 2679.0 | 82.64 | 82.6 | Primate models of movement disorders of basal ganglia origin. | M R DeLong | Trends Neurosci | 1990 | 1695404 | No |
| 604 | 5350 | 2675.0 | 133.12 | 66.6 | Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. | D Hanahan, J Folkman | Cell | 1996 | 8756718 | No |
| 605 | 2667 | 2667.0 | 0.0 | 0.0 | A simple technique for demonstrating centromeric heterochromatin. | A T Sumner | Exp Cell Res | 1972 | 4117921 | Yes |
| 606 | 5329 | 2664.5 | 165.55 | 82.8 | Glutathione. | A Meister, M E Anderson | Annu Rev Biochem | 1983 | 6137189 | No |
| 607 | 2664 | 2664.0 | 0.0 | 0.0 | Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. | P Cuatrecasas | J Biol Chem | 1970 | 5432796 | Yes |
| 608 | 2658 | 2658.0 | 60.18 | 60.2 | Nuclear factor-kappaB in cancer development and progression. | Michael Karin | Nature | 2006 | 16724054 | No |
| 609 | 2658 | 2658.0 | 68.69 | 68.7 | The resurgence of platinum-based cancer chemotherapy. | Lloyd Kelland | Nat Rev Cancer | 2007 | 17625587 | No |
| 610 | 5313 | 2656.5 | 154.55 | 77.3 | The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. | Taro Kawai, Shizuo Akira | Nat Immunol | 2010 | 20404851 | No |
| 611 | 5304 | 2652.0 | 115.85 | 57.9 | Emergence of scaling in random networks | Barabasi, Albert | Science | 1999 | 10521342 | Yes |
| 612 | 2651 | 2651.0 | 0.0 | 0.0 | Analysis of gene diversity in subdivided populations. | M Nei | Proc Natl Acad Sci U S A | 1973 | 4519626 | Yes |
| 613 | 5297 | 2648.5 | 166.5 | 83.2 | Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. | K Tamura, M Nei | Mol Biol Evol | 1993 | 8336541 | Yes |
| 614 | 5294 | 2647.0 | 138.8 | 69.4 | Exploring the full spectrum of macrophage activation. | David M Mosser, Justin P Edwards | Nat Rev Immunol | 2008 | 19029990 | No |
| 615 | 2644 | 2644.0 | 77.22 | 77.2 | RELION: implementation of a Bayesian approach to cryo-EM structure determination. | Sjors H W Scheres | J Struct Biol | 2012 | 23000701 | Yes |
| 616 | 5284 | 2642.0 | 189.19 | 94.6 | A method of comparing the areas under receiver operating characteristic curves derived from the same cases. | J A Hanley, B J McNeil | Radiology | 1983 | 6878708 | Yes |
| 617 | 2642 | 2642.0 | 54.9 | 54.9 | Papillomaviruses and cancer: from basic studies to clinical application. | Harald zur Hausen | Nat Rev Cancer | 2002 | 12044010 | No |
| 618 | 5274 | 2637.0 | 230.88 | 115.4 | The qualitative content analysis process. | Satu Elo, Helvi Kyngäs | J Adv Nurs | 2008 | 18352969 | Yes |
| 619 | 2635 | 2635.0 | 46.46 | 46.5 | Mechanisms underlying ubiquitination. | C M Pickart | Annu Rev Biochem | 2001 | 11395416 | No |
| 620 | 5268 | 2634.0 | 108.72 | 54.4 | Establishment in culture of pluripotential cells from mouse embryos. | M J Evans, M H Kaufman | Nature | 1981 | 7242681 | Yes |
| 621 | 7887 | 2629.0 | 182.3 | 60.8 | The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. | R C Lee, R L Feinbaum, V Ambros | Cell | 1993 | 8252621 | Yes |
| 622 | 10516 | 2629.0 | 229.67 | 57.4 | Cluster analysis and display of genome-wide expression patterns. | M B Eisen, P T Spellman, P O Brown, D Botstein | Proc Natl Acad Sci U S A | 1998 | 9843981 | Yes |
| 623 | 2628 | 2628.0 | 48.8 | 48.8 | Wnt signaling and cancer. | P Polakis | Genes Dev | 2000 | 10921899 | No |
| 624 | 2625 | 2625.0 | 54.2 | 54.2 | Interleukin-12 and the regulation of innate resistance and adaptive immunity. | Giorgio Trinchieri | Nat Rev Immunol | 2003 | 12563297 | No |
| 625 | 7868 | 2622.7 | 422.16 | 140.7 | Deep learning. | Yann LeCun, Yoshua Bengio, Geoffrey Hinton | Nature | 2015 | 26017442 | No |
| 626 | 5241 | 2620.5 | 0.0 | 0.0 | Some quantitative uses of drug antagonists. | O Arunlakshana, H O Schild | Br J Pharmacol Chemother | 1959 | 13651579 | Yes |
| 627 | 5226 | 2613.0 | 251.77 | 125.9 | phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. | Paul J McMurdie, Susan Holmes | PLoS One | 2013 | 23630581 | Yes |
| 628 | 2612 | 2612.0 | 60.65 | 60.6 | Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. | S A Bustin | J Mol Endocrinol | 2000 | 11013345 | No |
| 629 | 2611 | 2611.0 | 53.29 | 53.3 | The danger model: a renewed sense of self. | Polly Matzinger | Science | 2002 | 11951032 | Yes |
| 630 | 2610 | 2610.0 | 60.04 | 60.0 | Cell adhesion: the molecular basis of tissue architecture and morphogenesis. | B M Gumbiner | Cell | 1996 | 8608588 | No |
| 631 | 5219 | 2609.5 | 191.98 | 96.0 | Longitudinal data analysis for discrete and continuous outcomes. | S L Zeger, K Y Liang | Biometrics | 1986 | 3719049 | Yes |
| 632 | 20870 | 2608.8 | 469.98 | 58.7 | The Protein Data Bank. | H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E Bourne | Nucleic Acids Res | 2000 | 10592235 | Yes |
| 633 | 7823 | 2607.7 | 232.4 | 77.5 | Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. | G Evanno, S Regnaut, J Goudet | Mol Ecol | 2005 | 15969739 | Yes |
| 634 | 2602 | 2602.0 | 143.46 | 143.5 | Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. | Daniël Lakens | Front Psychol | 2013 | 24324449 | No |
| 635 | 5202 | 2601.0 | 183.48 | 91.7 | A simple, rapid, and sensitive DNA assay procedure. | C Labarca, K Paigen | Anal Biochem | 1980 | 6158890 | Yes |
| 636 | 2600 | 2600.0 | 82.62 | 82.6 | Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. | B Samuelsson | Science | 1983 | 6301011 | Yes |
| 637 | 2597 | 2597.0 | 120.77 | 120.8 | Detecting alcoholism. The CAGE questionnaire. | J A Ewing | JAMA | 1984 | 6471323 | Yes |
| 638 | 5192 | 2596.0 | 117.26 | 58.6 | Signal transduction by receptors with tyrosine kinase activity. | A Ullrich, J Schlessinger | Cell | 1990 | 2158859 | No |
| 639 | 2592 | 2592.0 | 52.4 | 52.4 | Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. | Shimon Sakaguchi | Annu Rev Immunol | 2004 | 15032588 | No |
| 640 | 5181 | 2590.5 | 164.22 | 82.1 | Complex brain networks: graph theoretical analysis of structural and functional systems. | Ed Bullmore, Olaf Sporns | Nat Rev Neurosci | 2009 | 19190637 | No |
| 641 | 5180 | 2590.0 | 107.09 | 53.5 | Innate immune recognition. | Charles A Janeway, Ruslan Medzhitov | Annu Rev Immunol | 2002 | 11861602 | No |
| 642 | 2589 | 2589.0 | 0.0 | 0.0 | The membrane actions of anesthetics and tranquilizers. | P Seeman | Pharmacol Rev | 1972 | 4565956 | No |
| 643 | 5176 | 2588.0 | 174.13 | 87.1 | Computed tomography--an increasing source of radiation exposure. | David J Brenner, Eric J Hall | N Engl J Med | 2007 | 18046031 | No |
| 644 | 2587 | 2587.0 | 65.04 | 65.0 | The nerve growth factor 35 years later. | R Levi-Montalcini | Science | 1987 | 3306916 | No |
| 645 | 5165 | 2582.5 | 0.0 | 0.0 | Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. | J Sedlak, R H Lindsay | Anal Biochem | 1968 | 4973948 | Yes |
| 646 | 2582 | 2582.0 | 0.0 | 0.0 | Elastic properties of lipid bilayers: theory and possible experiments. | W Helfrich | Z Naturforsch C | 1973 | 4273690 | Yes |
| 647 | 5163 | 2581.5 | 0.0 | 0.0 | Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. | L A Greene, A S Tischler | Proc Natl Acad Sci U S A | 1976 | 1065897 | Yes |
| 648 | 2581 | 2581.0 | 70.83 | 70.8 | Cellular and molecular mechanisms of fibrosis. | T A Wynn | J Pathol | 2008 | 18161745 | No |
| 649 | 2579 | 2579.0 | 0.0 | 0.0 | The biology of oxygen radicals. | I Fridovich | Science | 1978 | 210504 | Yes |
| 650 | 2572 | 2572.0 | 97.08 | 97.1 | Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. | Joseph P Weir | J Strength Cond Res | 2005 | 15705040 | No |
| 651 | 2570 | 2570.0 | 55.77 | 55.8 | G1 phase progression: cycling on cue. | C J Sherr | Cell | 1994 | 7954821 | No |
| 652 | 2568 | 2568.0 | 0.0 | 0.0 | The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. | R R Porter | Biochem J | 1959 | 14434282 | Yes |
| 653 | 5126 | 2563.0 | 192.14 | 96.1 | FLASH: fast length adjustment of short reads to improve genome assemblies. | Tanja Magoč, Steven L Salzberg | Bioinformatics | 2011 | 21903629 | Yes |
| 654 | 5125 | 2562.5 | 112.37 | 56.2 | Inflammation and cancer: back to Virchow? | F Balkwill, A Mantovani | Lancet | 2001 | 11229684 | No |
| 655 | 2560 | 2560.0 | 83.64 | 83.6 | Accelerated Profile HMM Searches. | Sean R Eddy | PLoS Comput Biol | 2011 | 22039361 | Yes |
| 656 | 2559 | 2559.0 | 81.27 | 81.3 | What are the functional consequences of neurocognitive deficits in schizophrenia? | M F Green | Am J Psychiatry | 1996 | 8610818 | No |
| 657 | 2559 | 2559.0 | 68.21 | 68.2 | Predictive reward signal of dopamine neurons. | W Schultz | J Neurophysiol | 1998 | 9658025 | No |
| 658 | 2559 | 2559.0 | 0.0 | 0.0 | Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. | O Smithies | Biochem J | 1955 | 13276348 | Yes |
| 659 | 2557 | 2557.0 | 62.57 | 62.6 | Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. | E C Butcher | Cell | 1991 | 1760836 | No |
| 660 | 5108 | 2554.0 | 0.0 | 0.0 | The Social Readjustment Rating Scale. | T H Holmes, R H Rahe | J Psychosom Res | 1967 | 6059863 | Yes |
| 661 | 2554 | 2554.0 | 73.35 | 73.3 | Delayed neuronal death in the gerbil hippocampus following ischemia. | T Kirino | Brain Res | 1982 | 7093691 | Yes |
| 662 | 2554 | 2554.0 | 61.18 | 61.2 | Memory--a century of consolidation. | J L McGaugh | Science | 2000 | 10634773 | No |
| 663 | 2551 | 2551.0 | 92.34 | 92.3 | Measures of reliability in sports medicine and science. | W G Hopkins | Sports Med | 2000 | 10907753 | Yes |
| 664 | 5096 | 2548.0 | 0.0 | 0.0 | Electrochemical photolysis of water at a semiconductor electrode. | A Fujishima, K Honda | Nature | 1972 | 12635268 | Yes |
| 665 | 2547 | 2547.0 | 0.0 | 0.0 | On the number of segregating sites in genetical models without recombination. | G A Watterson | Theor Popul Biol | 1975 | 1145509 | Yes |
| 666 | 2547 | 2547.0 | 60.82 | 60.8 | Autophagy: process and function. | Noboru Mizushima | Genes Dev | 2007 | 18006683 | No |
| 667 | 2542 | 2542.0 | 0.0 | 0.0 | Models for the specific adhesion of cells to cells. | G I Bell | Science | 1978 | 347575 | No |
| 668 | 5045 | 2522.5 | 158.69 | 79.3 | The L-arginine-nitric oxide pathway. | S Moncada, A Higgs | N Engl J Med | 1993 | 7504210 | No |
| 669 | 2522 | 2522.0 | 58.95 | 59.0 | Prostaglandins and leukotrienes: advances in eicosanoid biology. | C D Funk | Science | 2001 | 11729303 | No |
| 670 | 2517 | 2517.0 | 77.76 | 77.8 | Secretory products of macrophages. | C F Nathan | J Clin Invest | 1987 | 3543052 | No |
| 671 | 5029 | 2514.5 | 147.15 | 73.6 | Adherence to medication. | Lars Osterberg, Terrence Blaschke | N Engl J Med | 2005 | 16079372 | No |
| 672 | 2513 | 2513.0 | 93.5 | 93.5 | What is value in health care? | Michael E Porter | N Engl J Med | 2010 | 21142528 | Yes |
| 673 | 2511 | 2511.0 | 0.0 | 0.0 | Perceived exertion as an indicator of somatic stress. | G Borg | Scand J Rehabil Med | 1970 | 5523831 | Yes |
| 674 | 10043 | 2510.8 | 307.77 | 76.9 | Establishing a standard definition for child overweight and obesity worldwide: international survey. | T J Cole, M C Bellizzi, K M Flegal, W H Dietz | BMJ | 2000 | 10797032 | Yes |
| 675 | 5020 | 2510.0 | 172.78 | 86.4 | Complex network measures of brain connectivity: uses and interpretations. | Mikail Rubinov, Olaf Sporns | Neuroimage | 2010 | 19819337 | Yes |
| 676 | 2508 | 2508.0 | 50.83 | 50.8 | Universal control mechanism regulating onset of M-phase. | P Nurse | Nature | 1990 | 2138713 | No |
| 677 | 2507 | 2507.0 | 0.0 | 0.0 | The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. | M L Anson | J Gen Physiol | 1938 | 19873094 | Yes |
| 678 | 2504 | 2504.0 | 65.54 | 65.5 | The genetic legacy of the Quaternary ice ages. | G Hewitt | Nature | 2000 | 10879524 | No |
| 679 | 2502 | 2502.0 | 80.08 | 80.1 | adegenet: a R package for the multivariate analysis of genetic markers. | Thibaut Jombart | Bioinformatics | 2008 | 18397895 | Yes |
| 680 | 5003 | 2501.5 | 0.0 | 0.0 | A diagnostic interview: the schedule for affective disorders and schizophrenia. | J Endicott, R L Spitzer | Arch Gen Psychiatry | 1978 | 678037 | Yes |
| 681 | 7503 | 2501.0 | 182.23 | 60.7 | Pathogen recognition and innate immunity. | Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi | Cell | 2006 | 16497588 | No |
| 682 | 5001 | 2500.5 | 139.13 | 69.6 | Unified segmentation. | John Ashburner, Karl J Friston | Neuroimage | 2005 | 15955494 | Yes |
| 683 | 2499 | 2499.0 | 74.23 | 74.2 | A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. | Heng Li | Bioinformatics | 2011 | 21903627 | Yes |
| 684 | 2495 | 2495.0 | 0.0 | 0.0 | The catecholamine hypothesis of affective disorders: a review of supporting evidence. | J J Schildkraut | Am J Psychiatry | 1965 | 5319766 | No |
| 685 | 4989 | 2494.5 | 0.0 | 0.0 | Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. | P J Fraker, J C Speck | Biochem Biophys Res Commun | 1978 | 637870 | Yes |
| 686 | 2490 | 2490.0 | 0.0 | 0.0 | The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. | S Boyden | J Exp Med | 1962 | 13872176 | Yes |
| 687 | 2486 | 2486.0 | 0.0 | 0.0 | Colorimetric assay of catalase. | A K Sinha | Anal Biochem | 1972 | 4556490 | Yes |
| 688 | 2485 | 2485.0 | 99.26 | 99.3 | The Danish Civil Registration System. | Carsten Bøcker Pedersen | Scand J Public Health | 2011 | 21775345 | Yes |
| 689 | 2482 | 2482.0 | 55.63 | 55.6 | Bone resorption by osteoclasts. | S L Teitelbaum | Science | 2000 | 10968780 | No |
| 690 | 2481 | 2481.0 | 0.0 | 0.0 | Oxygen-dependent microbial killing by phagocytes (first of two parts). | B M Babior | N Engl J Med | 1978 | 24176 | Yes |
| 691 | 4962 | 2481.0 | 201.92 | 101.0 | A feature-integration theory of attention. | A M Treisman, G Gelade | Cogn Psychol | 1980 | 7351125 | Yes |
| 692 | 2481 | 2481.0 | 0.0 | 0.0 | Satellite cell of skeletal muscle fibers. | A Mauro | J Biophys Biochem Cytol | 1961 | 13768451 | Yes |
| 693 | 4956 | 2478.0 | 127.29 | 63.6 | Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. | Weizhong Li, Adam Godzik | Bioinformatics | 2006 | 16731699 | Yes |
| 694 | 4942 | 2471.0 | 0.0 | 0.0 | Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. | S Marklund, G Marklund | Eur J Biochem | 1974 | 4215654 | Yes |
| 695 | 4923 | 2461.5 | 159.23 | 79.6 | Accurate and simple analytic representation of the electron-gas correlation energy. | Perdew, Wang | Phys Rev B Condens Matter | 1992 | 10001404 | Yes |
| 696 | 2455 | 2455.0 | 66.59 | 66.6 | Dominant forces in protein folding. | K A Dill | Biochemistry | 1990 | 2207096 | No |
| 697 | 4907 | 2453.5 | 238.63 | 119.3 | GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. | Rod Peakall, Peter E Smouse | Bioinformatics | 2012 | 22820204 | Yes |
| 698 | 4905 | 2452.5 | 122.17 | 61.1 | Autophagy in the pathogenesis of disease. | Beth Levine, Guido Kroemer | Cell | 2008 | 18191218 | No |
| 699 | 2451 | 2451.0 | 72.1 | 72.1 | Formation and Structure of Self-Assembled Monolayers. | Abraham Ulman | Chem Rev | 1996 | 11848802 | Yes |
| 700 | 2451 | 2451.0 | 56.31 | 56.3 | Salt and drought stress signal transduction in plants. | Jian-Kang Zhu | Annu Rev Plant Biol | 2002 | 12221975 | No |
| 701 | 7329 | 2443.0 | 144.76 | 48.3 | Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. | Ron Edgar, Michael Domrachev, Alex E Lash | Nucleic Acids Res | 2002 | 11752295 | Yes |
| 702 | 2443 | 2443.0 | 58.3 | 58.3 | Vascular endothelial growth factor: basic science and clinical progress. | Napoleone Ferrara | Endocr Rev | 2004 | 15294883 | No |
| 703 | 2441 | 2441.0 | 55.24 | 55.2 | Social controls on cell survival and cell death. | M C Raff | Nature | 1992 | 1557121 | No |
| 704 | 4861 | 2430.5 | 160.48 | 80.2 | The neural basis of drug craving: an incentive-sensitization theory of addiction. | T E Robinson, K C Berridge | Brain Res Brain Res Rev | 1993 | 8401595 | No |
| 705 | 2428 | 2428.0 | 77.85 | 77.8 | Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. | Peter C Austin | Stat Med | 2009 | 19757444 | Yes |
| 706 | 4848 | 2424.0 | 98.55 | 49.3 | Untangling the ErbB signalling network. | Y Yarden, M X Sliwkowski | Nat Rev Mol Cell Biol | 2001 | 11252954 | No |
| 707 | 4847 | 2423.5 | 0.0 | 0.0 | Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. | J V Durnin, J Womersley | Br J Nutr | 1974 | 4843734 | Yes |
| 708 | 4841 | 2420.5 | 117.58 | 58.8 | Calculation of protein extinction coefficients from amino acid sequence data. | S C Gill, P H von Hippel | Anal Biochem | 1989 | 2610349 | Yes |
| 709 | 2420 | 2420.0 | 57.45 | 57.5 | Epigenetics in cancer. | Manel Esteller | N Engl J Med | 2008 | 18337604 | No |
| 710 | 2416 | 2416.0 | 57.86 | 57.9 | Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. | G P Smith | Science | 1985 | 4001944 | Yes |
| 711 | 4832 | 2416.0 | 103.25 | 51.6 | MicroRNAs: small RNAs with a big role in gene regulation. | Lin He, Gregory J Hannon | Nat Rev Genet | 2004 | 15211354 | No |
| 712 | 2416 | 2416.0 | 58.44 | 58.4 | Calcium signaling. | David E Clapham | Cell | 2007 | 18083096 | No |
| 713 | 2414 | 2414.0 | 59.09 | 59.1 | MapChart: software for the graphical presentation of linkage maps and QTLs. | R E Voorrips | J Hered | 2002 | 12011185 | Yes |
| 714 | 2413 | 2413.0 | 0.0 | 0.0 | Transduction of linked genetic characters of the host by bacteriophage P1. | E S Lennox | Virology | 1955 | 13267987 | Yes |
| 715 | 2410 | 2410.0 | 61.57 | 61.6 | Cancer nanotechnology: opportunities and challenges. | Mauro Ferrari | Nat Rev Cancer | 2005 | 15738981 | No |
| 716 | 9638 | 2409.5 | 464.16 | 116.0 | Cancer statistics, 2014. | Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin Jemal | CA Cancer J Clin | 2014 | 24399786 | Yes |
| 717 | 4814 | 2407.0 | 0.0 | 0.0 | Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. | J D Watson, F H Crick | Nature | 1953 | 13054692 | Yes |
| 718 | 4802 | 2401.0 | 0.0 | 0.0 | A general method applicable to the search for similarities in the amino acid sequence of two proteins. | S B Needleman, C D Wunsch | J Mol Biol | 1970 | 5420325 | Yes |
| 719 | 4796 | 2398.0 | 95.6 | 47.8 | CDK inhibitors: positive and negative regulators of G1-phase progression. | C J Sherr, J M Roberts | Genes Dev | 1999 | 10385618 | No |
| 720 | 2397 | 2397.0 | 65.87 | 65.9 | Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. | H G Gratzner | Science | 1982 | 7123245 | Yes |
| 721 | 2382 | 2382.0 | 0.0 | 0.0 | Electroimmuno assay. | C B Laurell | Scand J Clin Lab Invest Suppl | 1972 | 4114358 | Yes |
| 722 | 2382 | 2382.0 | 54.67 | 54.7 | Angiogenesis in life, disease and medicine. | Peter Carmeliet | Nature | 2005 | 16355210 | No |
| 723 | 2381 | 2381.0 | 0.0 | 0.0 | The glomerular permeability determined by dextran clearance using Sephadex gel filtration. | C E Mogensen | Scand J Clin Lab Invest | 1968 | 5637478 | Yes |
| 724 | 2379 | 2379.0 | 46.61 | 46.6 | Getting started with yeast. | F Sherman | Methods Enzymol | 1991 | 2005794 | Yes |
| 725 | 4751 | 2375.5 | 0.0 | 0.0 | Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. | J Silness, H Loe | Acta Odontol Scand | 1964 | 14158464 | Yes |
| 726 | 2369 | 2369.0 | 84.63 | 84.6 | DNA methylation age of human tissues and cell types. | Steve Horvath | Genome Biol | 2013 | 24138928 | Yes |
| 727 | 7104 | 2368.0 | 385.83 | 128.6 | Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. | P J Van Soest, J B Robertson, B A Lewis | J Dairy Sci | 1991 | 1660498 | No |
| 728 | 2367 | 2367.0 | 0.0 | 0.0 | A rapid radiochemical method for the determination of choline acetyltransferase. | F Fonnum | J Neurochem | 1975 | 1113118 | Yes |
| 729 | 2366 | 2366.0 | 51.45 | 51.5 | Evolving concepts of rheumatoid arthritis. | Gary S Firestein | Nature | 2003 | 12748655 | No |
| 730 | 2365 | 2365.0 | 98.77 | 98.8 | Qualitative research. Introducing focus groups. | J Kitzinger | BMJ | 1995 | 7633241 | Yes |
| 731 | 4724 | 2362.0 | 134.96 | 67.5 | Pattern recognition receptors and inflammation. | Osamu Takeuchi, Shizuo Akira | Cell | 2010 | 20303872 | No |
| 732 | 2361 | 2361.0 | 64.05 | 64.0 | The magical number 4 in short-term memory: a reconsideration of mental storage capacity. | N Cowan | Behav Brain Sci | 2001 | 11515286 | Yes |
| 733 | 2350 | 2350.0 | 48.35 | 48.4 | Tumour-educated macrophages promote tumour progression and metastasis. | Jeffrey W Pollard | Nat Rev Cancer | 2004 | 14708027 | No |
| 734 | 4697 | 2348.5 | 0.0 | 0.0 | Screening lambdagt recombinant clones by hybridization to single plaques in situ. | W D Benton, R W Davis | Science | 1977 | 322279 | Yes |
| 735 | 4694 | 2347.0 | 147.38 | 73.7 | Rapid isolation of high molecular weight plant DNA. | M G Murray, W F Thompson | Nucleic Acids Res | 1980 | 7433111 | Yes |
| 736 | 2345 | 2345.0 | 0.0 | 0.0 | A Rationale And Test For The Number Of Factors In Factor Analysis. | J L Horn | Psychometrika | 1965 | 14306381 | Yes |
| 737 | 2342 | 2342.0 | 51.54 | 51.5 | Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. | T Hunter | Cell | 1995 | 7834742 | No |
| 738 | 2339 | 2339.0 | 67.7 | 67.7 | Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. | P Correa | Cancer Res | 1992 | 1458460 | No |
| 739 | 9356 | 2339.0 | 296.9 | 74.2 | Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. | Qiong Wang, George M Garrity, James M Tiedje, James R Cole | Appl Environ Microbiol | 2007 | 17586664 | Yes |
| 740 | 2332 | 2332.0 | 73.23 | 73.2 | SF-36 health survey update. | J E Ware | Spine (Phila Pa 1976) | 2000 | 11124729 | No |
| 741 | 2327 | 2327.0 | 86.36 | 86.4 | Calmodulin plays a pivotal role in cellular regulation. | W Y Cheung | Science | 1980 | 6243188 | No |
| 742 | 4651 | 2325.5 | 0.0 | 0.0 | Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. | R A Laskey, A D Mills | Eur J Biochem | 1975 | 1175627 | Yes |
| 743 | 2323 | 2323.0 | 61.5 | 61.5 | Dietary pattern analysis: a new direction in nutritional epidemiology. | Frank B Hu | Curr Opin Lipidol | 2002 | 11790957 | No |
| 744 | 2319 | 2319.0 | 53.71 | 53.7 | A decade of molecular biology of retinoic acid receptors. | P Chambon | FASEB J | 1996 | 8801176 | No |
| 745 | 2316 | 2316.0 | 0.0 | 0.0 | The Michigan alcoholism screening test: the quest for a new diagnostic instrument. | M L Selzer | Am J Psychiatry | 1971 | 5565851 | Yes |
| 746 | 4629 | 2314.5 | 95.63 | 47.8 | Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. | D Bonnet, J E Dick | Nat Med | 1997 | 9212098 | Yes |
| 747 | 2314 | 2314.0 | 0.0 | 0.0 | Application of a microtechnique to viral serological investigations. | J L Sever | J Immunol | 1962 | 13910995 | Yes |
| 748 | 2313 | 2313.0 | 58.81 | 58.8 | Molecular basis of bacterial outer membrane permeability revisited. | Hiroshi Nikaido | Microbiol Mol Biol Rev | 2003 | 14665678 | No |
| 749 | 4618 | 2309.0 | 104.48 | 52.2 | Death receptors: signaling and modulation. | A Ashkenazi, V M Dixit | Science | 1998 | 9721089 | No |
| 750 | 2308 | 2308.0 | 52.02 | 52.0 | The structure and regulation of protein phosphatases. | P Cohen | Annu Rev Biochem | 1989 | 2549856 | No |
| 751 | 2305 | 2305.0 | 56.95 | 57.0 | Modularity and community structure in networks. | M E J Newman | Proc Natl Acad Sci U S A | 2006 | 16723398 | Yes |
| 752 | 2302 | 2302.0 | 0.0 | 0.0 | Inositol phospholipids and cell surface receptor function. | R H Michell | Biochim Biophys Acta | 1975 | 164246 | No |
| 753 | 2299 | 2299.0 | 0.0 | 0.0 | Separation of leukocytes from blood and bone marrow. Introduction. | A Böyum | Scand J Clin Lab Invest Suppl | 1968 | 5707208 | Yes |
| 754 | 4596 | 2298.0 | 92.1 | 46.0 | The phosphatidylinositol 3-Kinase AKT pathway in human cancer. | Igor Vivanco, Charles L Sawyers | Nat Rev Cancer | 2002 | 12094235 | No |
| 755 | 4591 | 2295.5 | 228.56 | 114.3 | Stress, social support, and the buffering hypothesis. | S Cohen, T A Wills | Psychol Bull | 1985 | 3901065 | No |
| 756 | 2295 | 2295.0 | 66.37 | 66.4 | Interleukin-1 and interleukin-1 antagonism. | C A Dinarello | Blood | 1991 | 1826616 | No |
| 757 | 2294 | 2294.0 | 57.5 | 57.5 | Bcl-2 and the regulation of programmed cell death. | J C Reed | J Cell Biol | 1994 | 8294493 | No |
| 758 | 2294 | 2294.0 | 0.0 | 0.0 | Muscle structure and theories of contraction. | A F Huxley | Prog Biophys Biophys Chem | 1957 | 13485191 | Yes |
| 759 | 4573 | 2286.5 | 0.0 | 0.0 | High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. | M N Berry, D S Friend | J Cell Biol | 1969 | 4900611 | Yes |
| 760 | 4573 | 2286.5 | 92.98 | 46.5 | Lipid rafts and signal transduction. | K Simons, D Toomre | Nat Rev Mol Cell Biol | 2000 | 11413487 | No |
| 761 | 2286 | 2286.0 | 0.0 | 0.0 | Evaluating the quality of medical care. | A Donabedian | Milbank Mem Fund Q | 1966 | 5338568 | No |
| 762 | 2284 | 2284.0 | 58.63 | 58.6 | Causes and consequences of microRNA dysregulation in cancer. | Carlo M Croce | Nat Rev Genet | 2009 | 19763153 | No |
| 763 | 2281 | 2281.0 | 0.0 | 0.0 | Stereochemistry of cooperative effects in haemoglobin. | M F Perutz | Nature | 1970 | 5528785 | Yes |
| 764 | 2281 | 2281.0 | 82.04 | 82.0 | A computational approach to edge detection. | J Canny | IEEE Trans Pattern Anal Mach Intell | 1986 | 21869365 | Yes |
| 765 | 4561 | 2280.5 | 123.02 | 61.5 | Management of hepatocellular carcinoma. | Jordi Bruix, Morris Sherman | Hepatology | 2005 | 16250051 | No |
| 766 | 6839 | 2279.7 | 0.0 | 0.0 | On The Nature Of Allosteric Transitions: A Plausible Model. | J Monod, J Wyman, J P Changeux | J Mol Biol | 1965 | 14343300 | Yes |
| 767 | 2277 | 2277.0 | 51.91 | 51.9 | Mitochondrial diseases in man and mouse. | D C Wallace | Science | 1999 | 10066162 | No |
| 768 | 2276 | 2276.0 | 45.84 | 45.8 | SV40-transformed simian cells support the replication of early SV40 mutants. | Y Gluzman | Cell | 1981 | 6260373 | Yes |
| 769 | 4552 | 2276.0 | 160.31 | 80.2 | The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. | S H Downs, N Black | J Epidemiol Community Health | 1998 | 9764259 | Yes |
| 770 | 6827 | 2275.7 | 308.54 | 102.8 | Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. | J L Cox, J M Holden, R Sagovsky | Br J Psychiatry | 1987 | 3651732 | Yes |
| 771 | 13627 | 2271.2 | 327.1 | 54.5 | Phaser crystallographic software. | Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J Read | J Appl Crystallogr | 2007 | 19461840 | Yes |
| 772 | 2266 | 2266.0 | 0.0 | 0.0 | The information capacity of the human motor system in controlling the amplitude of movement. | P M Fitts | J Exp Psychol | 1954 | 13174710 | Yes |
| 773 | 2265 | 2265.0 | 67.18 | 67.2 | Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. | M Leavitt | MedGenMed | 2001 | 11549951 | No |
| 774 | 2263 | 2263.0 | 76.46 | 76.5 | Glutamate, nitric oxide and cell-cell signalling in the nervous system. | J Garthwaite | Trends Neurosci | 1991 | 1708538 | No |
| 775 | 4525 | 2262.5 | 86.2 | 43.1 | A novel genetic system to detect protein-protein interactions. | S Fields, O Song | Nature | 1989 | 2547163 | Yes |
| 776 | 2262 | 2262.0 | 57.02 | 57.0 | A model for receptor-regulated calcium entry. | J W Putney | Cell Calcium | 1986 | 2420465 | No |
| 777 | 2262 | 2262.0 | 49.35 | 49.4 | Molecular physiology of P2X receptors. | R Alan North | Physiol Rev | 2002 | 12270951 | No |
| 778 | 2258 | 2258.0 | 48.51 | 48.5 | Telomere measurement by quantitative PCR. | Richard M Cawthon | Nucleic Acids Res | 2002 | 12000852 | Yes |
| 779 | 2252 | 2252.0 | 59.84 | 59.8 | A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. | P Chomczynski | Biotechniques | 1993 | 7692896 | Yes |
| 780 | 2251 | 2251.0 | 66.67 | 66.7 | Two-sided confidence intervals for the single proportion: comparison of seven methods. | R G Newcombe | Stat Med | 1998 | 9595616 | Yes |
| 781 | 4496 | 2248.0 | 103.22 | 51.6 | A simple and very efficient method for generating cDNA libraries. | U Gubler, B J Hoffman | Gene | 1983 | 6198242 | Yes |
| 782 | 2245 | 2245.0 | 71.69 | 71.7 | Reactive oxygen species and the central nervous system. | B Halliwell | J Neurochem | 1992 | 1402908 | No |
| 783 | 2240 | 2240.0 | 55.91 | 55.9 | The anatomy and taxonomy of protein structure. | J S Richardson | Adv Protein Chem | 1981 | 7020376 | No |
| 784 | 6708 | 2236.0 | 179.47 | 59.8 | ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. | Kai Wang, Mingyao Li, Hakon Hakonarson | Nucleic Acids Res | 2010 | 20601685 | Yes |
| 785 | 4469 | 2234.5 | 0.0 | 0.0 | Periodontal Disease In Pregnancy. I. Prevalence And Severity. | H Loe, J Silness | Acta Odontol Scand | 1963 | 14121956 | Yes |
| 786 | 6703 | 2234.3 | 307.45 | 102.5 | HISAT: a fast spliced aligner with low memory requirements. | Daehwan Kim, Ben Langmead, Steven L Salzberg | Nat Methods | 2015 | 25751142 | Yes |
| 787 | 4463 | 2231.5 | 0.0 | 0.0 | On the size of the active site in proteases. I. Papain. | I Schechter, A Berger | Biochem Biophys Res Commun | 1967 | 6035483 | Yes |
| 788 | 4463 | 2231.5 | 96.65 | 48.3 | New functions for the matrix metalloproteinases in cancer progression. | Mikala Egeblad, Zena Werb | Nat Rev Cancer | 2002 | 11990853 | No |
| 789 | 4463 | 2231.5 | 119.34 | 59.7 | Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. | Marie-Christine Daniel, Didier Astruc | Chem Rev | 2004 | 14719978 | No |
| 790 | 2231 | 2231.0 | 49.84 | 49.8 | Chemokines and leukocyte traffic. | M Baggiolini | Nature | 1998 | 9560152 | No |
| 791 | 4459 | 2229.5 | 0.0 | 0.0 | The interpretation of protein structures: estimation of static accessibility. | B Lee, F M Richards | J Mol Biol | 1971 | 5551392 | Yes |
| 792 | 2229 | 2229.0 | 68.4 | 68.4 | Efficient methods to compute genomic predictions. | P M VanRaden | J Dairy Sci | 2008 | 18946147 | Yes |
| 793 | 2227 | 2227.0 | 55.32 | 55.3 | Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. | J Kyhse-Andersen | J Biochem Biophys Methods | 1984 | 6530509 | Yes |
| 794 | 2226 | 2226.0 | 67.78 | 67.8 | Parkinson's disease: clinical features and diagnosis. | J Jankovic | J Neurol Neurosurg Psychiatry | 2008 | 18344392 | No |
| 795 | 2225 | 2225.0 | 65.85 | 65.8 | Physiology and neurobiology of stress and adaptation: central role of the brain. | Bruce S McEwen | Physiol Rev | 2007 | 17615391 | No |
| 796 | 2224 | 2224.0 | 0.0 | 0.0 | Mechanisms of action of transmitters and other substances on smooth muscle. | T B Bolton | Physiol Rev | 1979 | 37533 | No |
| 797 | 4445 | 2222.5 | 99.94 | 50.0 | Organization and expression of eucaryotic split genes coding for proteins. | R Breathnach, P Chambon | Annu Rev Biochem | 1981 | 6791577 | No |
| 798 | 4444 | 2222.0 | 116.59 | 58.3 | A receptor-mediated pathway for cholesterol homeostasis. | M S Brown, J L Goldstein | Science | 1986 | 3513311 | No |
| 799 | 2222 | 2222.0 | 53.02 | 53.0 | Mechanisms and genes of cellular suicide. | H Steller | Science | 1995 | 7878463 | No |
| 800 | 2221 | 2221.0 | 0.0 | 0.0 | [Rapid physiological coagulation method in determination of fibrinogen]. | A Clauss | Acta Haematol | 1957 | 13434757 | Yes |
| 801 | 2219 | 2219.0 | 42.52 | 42.5 | Java Treeview--extensible visualization of microarray data. | Alok J Saldanha | Bioinformatics | 2004 | 15180930 | Yes |
| 802 | 2218 | 2218.0 | 61.91 | 61.9 | Molecular diversity of glutamate receptors and implications for brain function. | S Nakanishi | Science | 1992 | 1329206 | No |
| 803 | 6650 | 2216.7 | 252.09 | 84.0 | featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. | Yang Liao, Gordon K Smyth, Wei Shi | Bioinformatics | 2014 | 24227677 | Yes |
| 804 | 4431 | 2215.5 | 149.67 | 74.8 | Random-effects models for longitudinal data. | N M Laird, J H Ware | Biometrics | 1982 | 7168798 | Yes |
| 805 | 2215 | 2215.0 | 53.22 | 53.2 | Protein kinase C and lipid signaling for sustained cellular responses. | Y Nishizuka | FASEB J | 1995 | 7737456 | No |
| 806 | 2214 | 2214.0 | 78.11 | 78.1 | Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. | B N Ames | Science | 1983 | 6351251 | No |
| 807 | 2212 | 2212.0 | 54.35 | 54.4 | Ischemic cell death in brain neurons. | P Lipton | Physiol Rev | 1999 | 10508238 | No |
| 808 | 2209 | 2209.0 | 68.42 | 68.4 | Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. | R A DeFronzo | Diabetes | 1988 | 3289989 | No |
| 809 | 4417 | 2208.5 | 134.11 | 67.1 | Neural mechanisms of selective visual attention. | R Desimone, J Duncan | Annu Rev Neurosci | 1995 | 7605061 | No |
| 810 | 4417 | 2208.5 | 104.45 | 52.2 | Signal integration in the endoplasmic reticulum unfolded protein response. | David Ron, Peter Walter | Nat Rev Mol Cell Biol | 2007 | 17565364 | No |
| 811 | 2208 | 2208.0 | 85.33 | 85.3 | Role of endothelium in responses of vascular smooth muscle. | R F Furchgott | Circ Res | 1983 | 6313250 | No |
| 812 | 6623 | 2207.7 | 152.93 | 51.0 | The biology of VEGF and its receptors. | Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter | Nat Med | 2003 | 12778165 | No |
| 813 | 2203 | 2203.0 | 0.0 | 0.0 | Removal of fatty acids from serum albumin by charcoal treatment. | R F Chen | J Biol Chem | 1967 | 6016603 | Yes |
| 814 | 6609 | 2203.0 | 194.7 | 64.9 | Bacterial biofilms: a common cause of persistent infections. | J W Costerton, P S Stewart, E P Greenberg | Science | 1999 | 10334980 | No |
| 815 | 2196 | 2196.0 | 87.18 | 87.2 | Effective physician-patient communication and health outcomes: a review. | M A Stewart | CMAJ | 1995 | 7728691 | Yes |
| 816 | 4392 | 2196.0 | 143.86 | 71.9 | Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. | R M Ryan, E L Deci | Am Psychol | 2000 | 11392867 | Yes |
| 817 | 4391 | 2195.5 | 0.0 | 0.0 | A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. | J E TILL, E A McCULLOCH | Radiat Res | 1961 | 13776896 | Yes |
| 818 | 2195 | 2195.0 | 42.02 | 42.0 | Targeting RAS signalling pathways in cancer therapy. | Julian Downward | Nat Rev Cancer | 2003 | 12509763 | No |
| 819 | 4389 | 2194.5 | 0.0 | 0.0 | The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. | J A Spudich, S Watt | J Biol Chem | 1971 | 4254541 | Yes |
| 820 | 2192 | 2192.0 | 56.2 | 56.2 | A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. | Pascal Fries | Trends Cogn Sci | 2005 | 16150631 | No |
| 821 | 4383 | 2191.5 | 113.42 | 56.7 | Reactive oxygen species: metabolism, oxidative stress, and signal transduction. | Klaus Apel, Heribert Hirt | Annu Rev Plant Biol | 2004 | 15377225 | No |
| 822 | 2191 | 2191.0 | 68.56 | 68.6 | Prooxidant states and tumor promotion. | P A Cerutti | Science | 1985 | 2981433 | No |
| 823 | 8759 | 2189.8 | 248.3 | 62.1 | GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. | Berk Hess, Carsten Kutzner, David van der Spoel, Erik Lindahl | J Chem Theory Comput | 2008 | 26620784 | Yes |
| 824 | 4378 | 2189.0 | 119.94 | 60.0 | Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. | C W Elston, I O Ellis | Histopathology | 1991 | 1757079 | Yes |
| 825 | 2188 | 2188.0 | 50.14 | 50.1 | A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. | Douglas C Wallace | Annu Rev Genet | 2005 | 16285865 | No |
| 826 | 4373 | 2186.5 | 197.93 | 99.0 | Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. | N S Jacobson, P Truax | J Consult Clin Psychol | 1991 | 2002127 | Yes |
| 827 | 2186 | 2186.0 | 65.19 | 65.2 | Stress, adaptation, and disease. Allostasis and allostatic load. | B S McEwen | Ann N Y Acad Sci | 1998 | 9629234 | No |
| 828 | 2185 | 2185.0 | 64.34 | 64.3 | The nuclear factor NF-kappaB pathway in inflammation. | Toby Lawrence | Cold Spring Harb Perspect Biol | 2009 | 20457564 | No |
| 829 | 4364 | 2182.0 | 128.79 | 64.4 | Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9167458 | Yes |
| 830 | 2180 | 2180.0 | 48.52 | 48.5 | The regulation of AP-1 activity by mitogen-activated protein kinases. | M Karin | J Biol Chem | 1995 | 7622446 | No |
| 831 | 2179 | 2179.0 | 41.73 | 41.7 | Histone acetylation in chromatin structure and transcription. | M Grunstein | Nature | 1997 | 9311776 | No |
| 832 | 2178 | 2178.0 | 64.6 | 64.6 | Scaffolds in tissue engineering bone and cartilage. | D W Hutmacher | Biomaterials | 2000 | 11071603 | Yes |
| 833 | 2176 | 2176.0 | 0.0 | 0.0 | Intracellular aspects of the process of protein synthesis. | G Palade | Science | 1975 | 1096303 | No |
| 834 | 6516 | 2172.0 | 177.2 | 59.1 | RNA-Seq: a revolutionary tool for transcriptomics. | Zhong Wang, Mark Gerstein, Michael Snyder | Nat Rev Genet | 2009 | 19015660 | No |
| 835 | 2170 | 2170.0 | 66.31 | 66.3 | Diagnosis of Alzheimer's disease. | Z S Khachaturian | Arch Neurol | 1985 | 2864910 | Yes |
| 836 | 2170 | 2170.0 | 58.95 | 59.0 | Immunological and inflammatory functions of the interleukin-1 family. | Charles A Dinarello | Annu Rev Immunol | 2009 | 19302047 | No |
| 837 | 6502 | 2167.3 | 205.67 | 68.6 | Arlequin (version 3.0): an integrated software package for population genetics data analysis. | Laurent Excoffier, Guillaume Laval, Stefan Schneider | Evol Bioinform Online | 2007 | 19325852 | Yes |
| 838 | 4333 | 2166.5 | 188.14 | 94.1 | Multiwfn: a multifunctional wavefunction analyzer. | Tian Lu, Feiwu Chen | J Comput Chem | 2012 | 22162017 | Yes |
| 839 | 4328 | 2164.0 | 99.61 | 49.8 | The Bcl-2 protein family: arbiters of cell survival. | J M Adams, S Cory | Science | 1998 | 9735050 | No |
| 840 | 2163 | 2163.0 | 79.86 | 79.9 | Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. | H W Steinbusch | Neuroscience | 1981 | 7017455 | Yes |
| 841 | 4322 | 2161.0 | 96.04 | 48.0 | Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. | F Sallusto, A Lanzavecchia | J Exp Med | 1994 | 8145033 | Yes |
| 842 | 2161 | 2161.0 | 47.45 | 47.5 | Cisplatin: mode of cytotoxic action and molecular basis of resistance. | Zahid H Siddik | Oncogene | 2003 | 14576837 | No |
| 843 | 4319 | 2159.5 | 87.62 | 43.8 | Mechanisms of TGF-beta signaling from cell membrane to the nucleus. | Yigong Shi, Joan Massagué | Cell | 2003 | 12809600 | No |
| 844 | 2158 | 2158.0 | 48.76 | 48.8 | Chemokines. | B J Rollins | Blood | 1997 | 9242519 | No |
| 845 | 2156 | 2156.0 | 81.4 | 81.4 | Specific impairments of planning. | T Shallice | Philos Trans R Soc Lond B Biol Sci | 1982 | 6125971 | Yes |
| 846 | 2156 | 2156.0 | 0.0 | 0.0 | Sedimentation Studies Of The Size And Shape Of Dna. | F W Studier | J Mol Biol | 1965 | 14290352 | Yes |
| 847 | 4310 | 2155.0 | 95.16 | 47.6 | Mass spectrometry-based proteomics. | Ruedi Aebersold, Matthias Mann | Nature | 2003 | 12634793 | No |
| 848 | 2153 | 2153.0 | 51.41 | 51.4 | Specification of cerebral cortical areas. | P Rakic | Science | 1988 | 3291116 | No |
| 849 | 8596 | 2149.0 | 297.36 | 74.3 | A brief measure for assessing generalized anxiety disorder: the GAD-7. | Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd Löwe | Arch Intern Med | 2006 | 16717171 | Yes |
| 850 | 2146 | 2146.0 | 0.0 | 0.0 | The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. | W W Cleland | Biochim Biophys Acta | 1963 | 14021667 | Yes |
| 851 | 2146 | 2146.0 | 93.91 | 93.9 | Central sensitization: implications for the diagnosis and treatment of pain. | Clifford J Woolf | Pain | 2011 | 20961685 | No |
| 852 | 2145 | 2145.0 | 47.26 | 47.3 | NOX enzymes and the biology of reactive oxygen. | J David Lambeth | Nat Rev Immunol | 2004 | 15039755 | No |
| 853 | 4287 | 2143.5 | 0.0 | 0.0 | The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. | H P Misra, I Fridovich | J Biol Chem | 1972 | 4623845 | Yes |
| 854 | 4286 | 2143.0 | 158.05 | 79.0 | The attention system of the human brain. | M I Posner, S E Petersen | Annu Rev Neurosci | 1990 | 2183676 | No |
| 855 | 2142 | 2142.0 | 0.0 | 0.0 | A new specific color reaction of hexuronic acids. | Z Dische | J Biol Chem | 1947 | 20281638 | Yes |
| 856 | 4283 | 2141.5 | 106.5 | 53.2 | Regulation of the mevalonate pathway. | J L Goldstein, M S Brown | Nature | 1990 | 1967820 | No |
| 857 | 2139 | 2139.0 | 41.9 | 41.9 | Protein modules and signalling networks. | T Pawson | Nature | 1995 | 7531822 | No |
| 858 | 6411 | 2137.0 | 185.28 | 61.8 | Quantum mechanical continuum solvation models. | Jacopo Tomasi, Benedetta Mennucci, Roberto Cammi | Chem Rev | 2005 | 16092826 | Yes |
| 859 | 4265 | 2132.5 | 110.02 | 55.0 | A global optimisation method for robust affine registration of brain images. | M Jenkinson, S Smith | Med Image Anal | 2001 | 11516708 | Yes |
| 860 | 4265 | 2132.5 | 0.0 | 0.0 | A Simplified Lead Citrate Stain For Use In Electron Microscopy. | J H Venable, R Coggeshall | J Cell Biol | 1965 | 14287192 | Yes |
| 861 | 4263 | 2131.5 | 108.99 | 54.5 | Myeloid-derived suppressor cells as regulators of the immune system. | Dmitry I Gabrilovich, Srinivas Nagaraj | Nat Rev Immunol | 2009 | 19197294 | No |
| 862 | 4259 | 2129.5 | 133.24 | 66.6 | SPSS and SAS procedures for estimating indirect effects in simple mediation models. | Kristopher J Preacher, Andrew F Hayes | Behav Res Methods Instrum Comput | 2004 | 15641418 | Yes |
| 863 | 4257 | 2128.5 | 124.69 | 62.3 | Distributed hierarchical processing in the primate cerebral cortex. | D J Felleman, D C Van Essen | Cereb Cortex | 1991 | 1822724 | No |
| 864 | 2128 | 2128.0 | 43.55 | 43.5 | The molecular biology of memory storage: a dialogue between genes and synapses. | E R Kandel | Science | 2001 | 11691980 | No |
| 865 | 4254 | 2127.0 | 0.0 | 0.0 | Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. | T V Bliss, T Lomo | J Physiol | 1973 | 4727084 | Yes |
| 866 | 2125 | 2125.0 | 0.0 | 0.0 | Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. | F F Jöbsis | Science | 1977 | 929199 | Yes |
| 867 | 2124 | 2124.0 | 89.26 | 89.3 | A systematic method for clinical description and classification of personality variants. A proposal. | C R Cloninger | Arch Gen Psychiatry | 1987 | 3579504 | Yes |
| 868 | 2122 | 2122.0 | 0.0 | 0.0 | Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. | T Higuchi | J Pharm Sci | 1963 | 14088963 | Yes |
| 869 | 4244 | 2122.0 | 99.68 | 49.8 | AKT/PKB signaling: navigating downstream. | Brendan D Manning, Lewis C Cantley | Cell | 2007 | 17604717 | No |
| 870 | 16975 | 2121.9 | 548.67 | 68.6 | The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. | D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C Siebert | N Engl J Med | 1993 | 8366922 | Yes |
| 871 | 4243 | 2121.5 | 105.31 | 52.7 | Protein misfolding, functional amyloid, and human disease. | Fabrizio Chiti, Christopher M Dobson | Annu Rev Biochem | 2006 | 16756495 | No |
| 872 | 19088 | 2120.9 | 424.11 | 47.1 | Cytoscape: a software environment for integrated models of biomolecular interaction networks. | Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey Ideker | Genome Res | 2003 | 14597658 | Yes |
| 873 | 4241 | 2120.5 | 101.65 | 50.8 | Assembly of asparagine-linked oligosaccharides. | R Kornfeld, S Kornfeld | Annu Rev Biochem | 1985 | 3896128 | No |
| 874 | 4240 | 2120.0 | 160.85 | 80.4 | Self-rated health and mortality: a review of twenty-seven community studies. | E L Idler, Y Benyamini | J Health Soc Behav | 1997 | 9097506 | No |
| 875 | 2119 | 2119.0 | 98.65 | 98.7 | Structural Model Evaluation and Modification: An Interval Estimation Approach. | J H Steiger | Multivariate Behav Res | 1990 | 26794479 | Yes |
| 876 | 4235 | 2117.5 | 0.0 | 0.0 | Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. | R B Devereux, N Reichek | Circulation | 1977 | 138494 | Yes |
| 877 | 2115 | 2115.0 | 40.0 | 40.0 | Automated electron microscope tomography using robust prediction of specimen movements. | David N Mastronarde | J Struct Biol | 2005 | 16182563 | Yes |
| 878 | 4229 | 2114.5 | 107.24 | 53.6 | Function and activation of NF-kappa B in the immune system. | P A Baeuerle, T Henkel | Annu Rev Immunol | 1994 | 8011280 | No |
| 879 | 4227 | 2113.5 | 110.12 | 55.1 | Acute-phase proteins and other systemic responses to inflammation. | C Gabay, I Kushner | N Engl J Med | 1999 | 9971870 | No |
| 880 | 2113 | 2113.0 | 0.0 | 0.0 | Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. | D Aminoff | Biochem J | 1961 | 13860975 | Yes |
| 881 | 4225 | 2112.5 | 129.87 | 64.9 | Missing data: our view of the state of the art. | Joseph L Schafer, John W Graham | Psychol Methods | 2002 | 12090408 | Yes |
| 882 | 2112 | 2112.0 | 50.38 | 50.4 | Patterns of amino acids near signal-sequence cleavage sites. | G von Heijne | Eur J Biochem | 1983 | 6852022 | Yes |
| 883 | 4220 | 2110.0 | 112.37 | 56.2 | The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. | Karen Bedard, Karl-Heinz Krause | Physiol Rev | 2007 | 17237347 | No |
| 884 | 2109 | 2109.0 | 49.24 | 49.2 | Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. | G Trinchieri | Annu Rev Immunol | 1995 | 7612223 | No |
| 885 | 2107 | 2107.0 | 70.89 | 70.9 | Working memory. | A Baddeley | Science | 1992 | 1736359 | No |
| 886 | 2107 | 2107.0 | 0.0 | 0.0 | The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. | D E Atkinson | Biochemistry | 1968 | 4972613 | Yes |
| 887 | 2104 | 2104.0 | 0.0 | 0.0 | The plasma lecithins:cholesterol acyltransferase reaction. | J A Glomset | J Lipid Res | 1968 | 4868699 | No |
| 888 | 2102 | 2102.0 | 44.84 | 44.8 | Mammalian G1 cyclins. | C J Sherr | Cell | 1993 | 8513492 | No |
| 889 | 4201 | 2100.5 | 123.68 | 61.8 | Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. | J S Beckman, W H Koppenol | Am J Physiol | 1996 | 8944624 | No |
| 890 | 2100 | 2100.0 | 0.0 | 0.0 | Isolation by Distance. | S Wright | Genetics | 1943 | 17247074 | Yes |
| 891 | 2099 | 2099.0 | 69.33 | 69.3 | The unfolded protein response: controlling cell fate decisions under ER stress and beyond. | Claudio Hetz | Nat Rev Mol Cell Biol | 2012 | 22251901 | No |
| 892 | 4194 | 2097.0 | 121.42 | 60.7 | Angiogenic factors. | J Folkman, M Klagsbrun | Science | 1987 | 2432664 | No |
| 893 | 2095 | 2095.0 | 53.42 | 53.4 | RGD and other recognition sequences for integrins. | E Ruoslahti | Annu Rev Cell Dev Biol | 1996 | 8970741 | No |
| 894 | 2095 | 2095.0 | 46.74 | 46.7 | Nitric oxide and the immune response. | C Bogdan | Nat Immunol | 2001 | 11577346 | No |
| 895 | 2094 | 2094.0 | 56.14 | 56.1 | T cell exhaustion. | E John Wherry | Nat Immunol | 2011 | 21739672 | No |
| 896 | 4183 | 2091.5 | 159.8 | 79.9 | The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. | P F Lovibond, S H Lovibond | Behav Res Ther | 1995 | 7726811 | Yes |
| 897 | 6271 | 2090.3 | 146.08 | 48.7 | MOLMOL: a program for display and analysis of macromolecular structures. | R Koradi, M Billeter, K Wüthrich | J Mol Graph | 1996 | 8744573 | Yes |
| 898 | 6270 | 2090.0 | 0.0 | 0.0 | Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. | B N Ames, J Mccann, E Yamasaki | Mutat Res | 1975 | 768755 | Yes |
| 899 | 2089 | 2089.0 | 53.62 | 53.6 | Breast cancer and hormone-replacement therapy in the Million Women Study. | Valerie Beral | Lancet | 2003 | 12927427 | Yes |
| 900 | 2088 | 2088.0 | 59.26 | 59.3 | Accurate Coulomb-fitting basis sets for H to Rn. | Florian Weigend | Phys Chem Chem Phys | 2006 | 16633586 | Yes |
| 901 | 4174 | 2087.0 | 107.21 | 53.6 | Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. | E Lander, L Kruglyak | Nat Genet | 1995 | 7581446 | Yes |
| 902 | 4172 | 2086.0 | 163.55 | 81.8 | Extracellular vesicles: exosomes, microvesicles, and friends. | Graça Raposo, Willem Stoorvogel | J Cell Biol | 2013 | 23420871 | No |
| 903 | 2084 | 2084.0 | 63.89 | 63.9 | The unbiased estimation of number and sizes of arbitrary particles using the disector. | D C Sterio | J Microsc | 1984 | 6737468 | Yes |
| 904 | 6250 | 2083.3 | 182.02 | 60.7 | Immunity, inflammation, and cancer. | Sergei I Grivennikov, Florian R Greten, Michael Karin | Cell | 2010 | 20303878 | No |
| 905 | 6243 | 2081.0 | 0.0 | 0.0 | Glucose clamp technique: a method for quantifying insulin secretion and resistance. | R A DeFronzo, J D Tobin, R Andres | Am J Physiol | 1979 | 382871 | Yes |
| 906 | 2081 | 2081.0 | 75.84 | 75.8 | Epidemiology of viral hepatitis and hepatocellular carcinoma. | Hashem B El-Serag | Gastroenterology | 2012 | 22537432 | No |
| 907 | 2080 | 2080.0 | 49.42 | 49.4 | The inflammatory reflex. | Kevin J Tracey | Nature | 2002 | 12490958 | No |
| 908 | 2078 | 2078.0 | 0.0 | 0.0 | Method For Assay Of Intestinal Disaccharidases. | A Dahlqvist | Anal Biochem | 1964 | 14106916 | Yes |
| 909 | 6232 | 2077.3 | 182.93 | 61.0 | Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. | C E Murry, R B Jennings, K A Reimer | Circulation | 1986 | 3769170 | Yes |
| 910 | 2076 | 2076.0 | 67.99 | 68.0 | Biodiesel from microalgae. | Yusuf Chisti | Biotechnol Adv | 2007 | 17350212 | No |
| 911 | 4143 | 2071.5 | 119.64 | 59.8 | Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. | Michael D Fox, Marcus E Raichle | Nat Rev Neurosci | 2007 | 17704812 | No |
| 912 | 2069 | 2069.0 | 0.0 | 0.0 | Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. | P Mitchell | Biol Rev Camb Philos Soc | 1966 | 5329743 | No |
| 913 | 2068 | 2068.0 | 46.32 | 46.3 | Complement. First of two parts. | M J Walport | N Engl J Med | 2001 | 11287977 | No |
| 914 | 2067 | 2067.0 | 0.0 | 0.0 | Presidential Address-1976. Social support as a moderator of life stress. | S Cobb | Psychosom Med | 1976 | 981490 | Yes |
| 915 | 2066 | 2066.0 | 49.34 | 49.3 | Rab GTPases as coordinators of vesicle traffic. | Harald Stenmark | Nat Rev Mol Cell Biol | 2009 | 19603039 | No |
| 916 | 4131 | 2065.5 | 113.5 | 56.8 | UniFrac: a new phylogenetic method for comparing microbial communities. | Catherine Lozupone, Rob Knight | Appl Environ Microbiol | 2005 | 16332807 | Yes |
| 917 | 2065 | 2065.0 | 0.0 | 0.0 | Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. | J W Littlefield | Science | 1964 | 14168277 | Yes |
| 918 | 2064 | 2064.0 | 0.0 | 0.0 | Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. | J C Skou | Physiol Rev | 1965 | 14337569 | No |
| 919 | 2063 | 2063.0 | 70.14 | 70.1 | A classification of glycosyl hydrolases based on amino acid sequence similarities. | B Henrissat | Biochem J | 1991 | 1747104 | Yes |
| 920 | 4125 | 2062.5 | 87.76 | 43.9 | A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. | G Shaw, R Kamen | Cell | 1986 | 3488815 | Yes |
| 921 | 4124 | 2062.0 | 123.67 | 61.8 | The number of people with glaucoma worldwide in 2010 and 2020. | H A Quigley, A T Broman | Br J Ophthalmol | 2006 | 16488940 | Yes |
| 922 | 6181 | 2060.3 | 0.0 | 0.0 | Immunochemical quantitation of antigens by single radial immunodiffusion. | G Mancini, A O Carbonara, J F Heremans | Immunochemistry | 1965 | 4956917 | Yes |
| 923 | 2058 | 2058.0 | 68.05 | 68.0 | Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. | W A Craig | Clin Infect Dis | 1998 | 9455502 | No |
| 924 | 2058 | 2058.0 | 68.38 | 68.4 | Human error: models and management. | J Reason | BMJ | 2000 | 10720363 | Yes |
| 925 | 2057 | 2057.0 | 0.0 | 0.0 | Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. | G Bertani | J Bacteriol | 1951 | 14888646 | Yes |
| 926 | 6170 | 2056.7 | 164.41 | 54.8 | Cortical surface-based analysis. I. Segmentation and surface reconstruction. | A M Dale, B Fischl, M I Sereno | Neuroimage | 1999 | 9931268 | Yes |
| 927 | 2055 | 2055.0 | 57.99 | 58.0 | Superoxide radical and superoxide dismutases. | I Fridovich | Annu Rev Biochem | 1995 | 7574505 | No |
| 928 | 4107 | 2053.5 | 103.78 | 51.9 | Nonparametric permutation tests for functional neuroimaging: a primer with examples. | Thomas E Nichols, Andrew P Holmes | Hum Brain Mapp | 2002 | 11747097 | Yes |
| 929 | 4106 | 2053.0 | 0.0 | 0.0 | Plaque formation and isolation of pure lines with poliomyelitis viruses. | R Dulbecco, M Vogt | J Exp Med | 1954 | 13130792 | Yes |
| 930 | 2049 | 2049.0 | 85.55 | 85.5 | Missing data analysis: making it work in the real world. | John W Graham | Annu Rev Psychol | 2009 | 18652544 | No |
| 931 | 4097 | 2048.5 | 81.12 | 40.6 | The fundamental role of epigenetic events in cancer. | Peter A Jones, Stephen B Baylin | Nat Rev Genet | 2002 | 12042769 | No |
| 932 | 2047 | 2047.0 | 42.86 | 42.9 | G1 events and regulation of cell proliferation. | A B Pardee | Science | 1989 | 2683075 | No |
| 933 | 2047 | 2047.0 | 43.05 | 43.0 | Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. | Shimon Sakaguchi | Nat Immunol | 2005 | 15785760 | No |
| 934 | 2047 | 2047.0 | 52.55 | 52.5 | Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. | Jane Glazebrook | Annu Rev Phytopathol | 2005 | 16078883 | No |
| 935 | 4093 | 2046.5 | 0.0 | 0.0 | Judgment under Uncertainty: Heuristics and Biases. | A Tversky, D Kahneman | Science | 1974 | 17835457 | Yes |
| 936 | 2046 | 2046.0 | 53.27 | 53.3 | Inferring the historical patterns of biological evolution. | M Pagel | Nature | 1999 | 10553904 | Yes |
| 937 | 2045 | 2045.0 | 84.3 | 84.3 | Role of Streptococcus mutans in human dental decay. | W J Loesche | Microbiol Rev | 1986 | 3540569 | No |
| 938 | 2045 | 2045.0 | 56.91 | 56.9 | The importance of selenium to human health. | M P Rayman | Lancet | 2000 | 10963212 | No |
| 939 | 4089 | 2044.5 | 112.58 | 56.3 | Alzheimer's disease: the amyloid cascade hypothesis. | J A Hardy, G A Higgins | Science | 1992 | 1566067 | No |
| 940 | 2044 | 2044.0 | 58.57 | 58.6 | Pancreatic cancer. | Manuel Hidalgo | N Engl J Med | 2010 | 20427809 | No |
| 941 | 4082 | 2041.0 | 115.33 | 57.7 | A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. | Y Matsumura, H Maeda | Cancer Res | 1986 | 2946403 | Yes |
| 942 | 2041 | 2041.0 | 67.38 | 67.4 | Eye movements in reading and information processing: 20 years of research. | K Rayner | Psychol Bull | 1998 | 9849112 | No |
| 943 | 2041 | 2041.0 | 62.13 | 62.1 | Hybrid porous solids: past, present, future. | Gérard Férey | Chem Soc Rev | 2008 | 18197340 | Yes |
| 944 | 2040 | 2040.0 | 59.8 | 59.8 | ATP-regulated K+ channels in cardiac muscle. | A Noma | Nature | 1983 | 6310409 | Yes |
| 945 | 2039 | 2039.0 | 83.36 | 83.4 | A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. | E L Bradley | Arch Surg | 1993 | 8489394 | No |
| 946 | 4072 | 2036.0 | 130.52 | 65.3 | Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. | Jeng-Da Chai, Martin Head-Gordon | Phys Chem Chem Phys | 2008 | 18989472 | Yes |
| 947 | 4068 | 2034.0 | 0.0 | 0.0 | Loss of recent memory after bilateral hippocampal lesions. | W B Scoville, B Milner | J Neurol Neurosurg Psychiatry | 1957 | 13406589 | Yes |
| 948 | 4063 | 2031.5 | 100.05 | 50.0 | Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. | P Liang, A B Pardee | Science | 1992 | 1354393 | Yes |
| 949 | 2031 | 2031.0 | 41.43 | 41.4 | Mechanisms of type-I- and type-II-interferon-mediated signalling. | Leonidas C Platanias | Nat Rev Immunol | 2005 | 15864272 | No |
| 950 | 2029 | 2029.0 | 40.09 | 40.1 | Shelterin: the protein complex that shapes and safeguards human telomeres. | Titia de Lange | Genes Dev | 2005 | 16166375 | No |
| 951 | 2028 | 2028.0 | 48.22 | 48.2 | Interleukin-2: inception, impact, and implications. | K A Smith | Science | 1988 | 3131876 | No |
| 952 | 2028 | 2028.0 | 67.51 | 67.5 | Plant products as antimicrobial agents. | M M Cowan | Clin Microbiol Rev | 1999 | 10515903 | No |
| 953 | 2027 | 2027.0 | 54.52 | 54.5 | Working memory: looking back and looking forward. | Alan Baddeley | Nat Rev Neurosci | 2003 | 14523382 | No |
| 954 | 2023 | 2023.0 | 0.0 | 0.0 | A rating instrument for anxiety disorders. | W W Zung | Psychosomatics | 1971 | 5172928 | Yes |
| 955 | 2023 | 2023.0 | 62.77 | 62.8 | A two process model of sleep regulation. | A A Borbély | Hum Neurobiol | 1982 | 7185792 | Yes |
| 956 | 2022 | 2022.0 | 54.17 | 54.2 | The molecular pathology of Alzheimer's disease. | D J Selkoe | Neuron | 1991 | 1673054 | No |
| 957 | 2021 | 2021.0 | 0.0 | 0.0 | Analysis of bacteriophage T7 early RNAs and proteins on slab gels. | F W Studier | J Mol Biol | 1973 | 4760132 | Yes |
| 958 | 2021 | 2021.0 | 67.51 | 67.5 | Ethical authorship and publishing. | Andrew J S Coats | Int J Cardiol | 2009 | 19046787 | No |
| 959 | 6062 | 2020.7 | 161.77 | 53.9 | Canonical sampling through velocity rescaling. | Giovanni Bussi, Davide Donadio, Michele Parrinello | J Chem Phys | 2007 | 17212484 | Yes |
| 960 | 2018 | 2018.0 | 0.0 | 0.0 | Antigen-antibody reactions in gels. | O Ouchterlony | Acta Pathol Microbiol Scand | 1949 | 18143039 | Yes |
| 961 | 2017 | 2017.0 | 62.77 | 62.8 | Fetal origins of coronary heart disease. | D J Barker | BMJ | 1995 | 7613432 | No |
| 962 | 2014 | 2014.0 | 44.59 | 44.6 | Structural design and molecular evolution of a cytokine receptor superfamily. | J F Bazan | Proc Natl Acad Sci U S A | 1990 | 2169613 | Yes |
| 963 | 2012 | 2012.0 | 47.76 | 47.8 | Calcium signaling. | D E Clapham | Cell | 1995 | 7834745 | No |
| 964 | 2012 | 2012.0 | 53.11 | 53.1 | The heme oxygenase system: a regulator of second messenger gases. | M D Maines | Annu Rev Pharmacol Toxicol | 1997 | 9131263 | No |
| 965 | 4022 | 2011.0 | 106.3 | 53.1 | The heat-shock proteins. | S Lindquist, E A Craig | Annu Rev Genet | 1988 | 2853609 | No |
| 966 | 2011 | 2011.0 | 144.7 | 144.7 | Minimap2: pairwise alignment for nucleotide sequences. | Heng Li | Bioinformatics | 2018 | 29750242 | Yes |
| 967 | 4015 | 2007.5 | 80.85 | 40.4 | Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. | M Gossen, H Bujard | Proc Natl Acad Sci U S A | 1992 | 1319065 | Yes |
| 968 | 4011 | 2005.5 | 109.79 | 54.9 | New perspectives in cell adhesion: RGD and integrins. | E Ruoslahti, M D Pierschbacher | Science | 1987 | 2821619 | No |
| 969 | 2004 | 2004.0 | 51.19 | 51.2 | Determination and analysis of urea and guanidine hydrochloride denaturation curves. | C N Pace | Methods Enzymol | 1986 | 3773761 | Yes |
| 970 | 4008 | 2004.0 | 0.0 | 0.0 | Genetic regulatory mechanisms in the synthesis of proteins. | F Jacob, J Monod | J Mol Biol | 1961 | 13718526 | Yes |
| 971 | 2003 | 2003.0 | 39.57 | 39.6 | NK cell recognition. | Lewis L Lanier | Annu Rev Immunol | 2005 | 15771571 | No |
| 972 | 2001 | 2001.0 | 53.24 | 53.2 | Descending control of pain. | Mark J Millan | Prog Neurobiol | 2002 | 12034378 | No |
| 973 | 1999 | 1999.0 | 42.5 | 42.5 | XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. | D E McRee | J Struct Biol | 1999 | 10222271 | Yes |
| 974 | 1998 | 1998.0 | 67.98 | 68.0 | Qualitative research: standards, challenges, and guidelines. | K Malterud | Lancet | 2001 | 11513933 | Yes |
| 975 | 1998 | 1998.0 | 65.43 | 65.4 | Spinal and supraspinal factors in human muscle fatigue. | S C Gandevia | Physiol Rev | 2001 | 11581501 | No |
| 976 | 7984 | 1996.0 | 180.99 | 45.2 | Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. | A Krogh, B Larsson, G von Heijne, E L Sonnhammer | J Mol Biol | 2001 | 11152613 | Yes |
| 977 | 1994 | 1994.0 | 47.39 | 47.4 | Pathways towards and away from Alzheimer's disease. | Mark P Mattson | Nature | 2004 | 15295589 | No |
| 978 | 1993 | 1993.0 | 68.81 | 68.8 | Simplified calculation of body-surface area. | R D Mosteller | N Engl J Med | 1987 | 3657876 | Yes |
| 979 | 1993 | 1993.0 | 57.92 | 57.9 | Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. | Claudiu T Supuran | Nat Rev Drug Discov | 2008 | 18167490 | No |
| 980 | 21903 | 1991.2 | 477.05 | 43.4 | Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. | Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P Mesirov | Proc Natl Acad Sci U S A | 2005 | 16199517 | Yes |
| 981 | 1991 | 1991.0 | 0.0 | 0.0 | The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. | U E Loening | Biochem J | 1967 | 5339944 | Yes |
| 982 | 3982 | 1991.0 | 101.73 | 50.9 | Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. | Hashem B El-Serag, K Lenhard Rudolph | Gastroenterology | 2007 | 17570226 | No |
| 983 | 3981 | 1990.5 | 104.81 | 52.4 | Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. | M Matsuda, R A DeFronzo | Diabetes Care | 1999 | 10480510 | Yes |
| 984 | 1990 | 1990.0 | 50.0 | 50.0 | Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. | Edward V Loftus | Gastroenterology | 2004 | 15168363 | Yes |
| 985 | 3980 | 1990.0 | 112.5 | 56.2 | Application of phylogenetic networks in evolutionary studies. | Daniel H Huson, David Bryant | Mol Biol Evol | 2006 | 16221896 | Yes |
| 986 | 1988 | 1988.0 | 58.38 | 58.4 | Protein oxidation and aging. | E R Stadtman | Science | 1992 | 1355616 | No |
| 987 | 1988 | 1988.0 | 55.5 | 55.5 | The blood-brain barrier in health and chronic neurodegenerative disorders. | Berislav V Zlokovic | Neuron | 2008 | 18215617 | No |
| 988 | 11924 | 1987.3 | 270.77 | 45.1 | NMRPipe: a multidimensional spectral processing system based on UNIX pipes. | F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A Bax | J Biomol NMR | 1995 | 8520220 | Yes |
| 989 | 3972 | 1986.0 | 81.65 | 40.8 | Mammalian MAP kinase signalling cascades. | L Chang, M Karin | Nature | 2001 | 11242034 | No |
| 990 | 3970 | 1985.0 | 128.94 | 64.5 | A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. | Gary J Bennett, Y-K Xie | Pain | 1988 | 2837713 | Yes |
| 991 | 1985 | 1985.0 | 0.0 | 0.0 | Purinergic nerves. | G Burnstock | Pharmacol Rev | 1972 | 4404211 | No |
| 992 | 5950 | 1983.3 | 117.81 | 39.3 | Control of regulatory T cell development by the transcription factor Foxp3. | Shohei Hori, Takashi Nomura, Shimon Sakaguchi | Science | 2003 | 12522256 | Yes |
| 993 | 1982 | 1982.0 | 42.15 | 42.1 | Role of angiogenesis in tumor growth and metastasis. | Judah Folkman | Semin Oncol | 2002 | 12516034 | No |
| 994 | 3963 | 1981.5 | 98.01 | 49.0 | Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. | G G Glenner, C W Wong | Biochem Biophys Res Commun | 1984 | 6375662 | Yes |
| 995 | 1978 | 1978.0 | 64.89 | 64.9 | Social cognitive theory: an agentic perspective. | A Bandura | Annu Rev Psychol | 2001 | 11148297 | Yes |
| 996 | 1975 | 1975.0 | 66.6 | 66.6 | The free-energy principle: a unified brain theory? | Karl Friston | Nat Rev Neurosci | 2010 | 20068583 | No |
| 997 | 1973 | 1973.0 | 70.95 | 71.0 | Determination of glutathione and glutathione disulfide in biological samples. | M E Anderson | Methods Enzymol | 1985 | 4088074 | Yes |
| 998 | 1970 | 1970.0 | 56.51 | 56.5 | Estimating causal effects from large data sets using propensity scores. | D B Rubin | Ann Intern Med | 1997 | 9382394 | No |
| 999 | 1969 | 1969.0 | 93.35 | 93.3 | Microplastics in the marine environment. | Anthony L Andrady | Mar Pollut Bull | 2011 | 21742351 | No |
| 1000 | 7875 | 1968.8 | 312.14 | 78.0 | Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. | Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg Lang | Behav Res Methods | 2009 | 19897823 | Yes |
| 1001 | 1968 | 1968.0 | 53.47 | 53.5 | Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. | J Folkman | N Engl J Med | 1995 | 7491141 | No |
| 1002 | 1966 | 1966.0 | 83.05 | 83.0 | The validity and practicality of sun-reactive skin types I through VI. | T B Fitzpatrick | Arch Dermatol | 1988 | 3377516 | Yes |
| 1003 | 3932 | 1966.0 | 0.0 | 0.0 | Variations in pattern of pubertal changes in girls. | W A Marshall, J M Tanner | Arch Dis Child | 1969 | 5785179 | Yes |
| 1004 | 1963 | 1963.0 | 40.93 | 40.9 | Mechanisms of intracellular protein transport. | J E Rothman | Nature | 1994 | 7969419 | No |
| 1005 | 5878 | 1959.3 | 121.85 | 40.6 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel, J D Roberts, R A Zakour | Methods Enzymol | 1987 | 3323813 | Yes |
| 1006 | 1959 | 1959.0 | 0.0 | 0.0 | Analysis of tissue and arterial blood temperatures in the resting human forearm. | H H Pennes | J Appl Physiol | 1948 | 18887578 | Yes |
| 1007 | 3914 | 1957.0 | 180.98 | 90.5 | Stages and processes of self-change of smoking: toward an integrative model of change. | J O Prochaska, C C DiClemente | J Consult Clin Psychol | 1983 | 6863699 | Yes |
| 1008 | 1957 | 1957.0 | 54.97 | 55.0 | The episodic buffer: a new component of working memory? | Baddeley | Trends Cogn Sci | 2000 | 11058819 | Yes |
| 1009 | 1956 | 1956.0 | 72.14 | 72.1 | International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. | C Herrmann | J Psychosom Res | 1997 | 9055211 | No |
| 1010 | 11733 | 1955.5 | 401.08 | 66.8 | Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. | Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell Parkin | Int J Cancer | 2010 | 21351269 | Yes |
| 1011 | 3910 | 1955.0 | 93.5 | 46.8 | Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. | B A Reynolds, S Weiss | Science | 1992 | 1553558 | Yes |
| 1012 | 1955 | 1955.0 | 87.19 | 87.2 | The Children's Depression, Inventory (CDI). | M Kovacs | Psychopharmacol Bull | 1985 | 4089116 | Yes |
| 1013 | 1954 | 1954.0 | 0.0 | 0.0 | The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. | S V Boyden | J Exp Med | 1951 | 14803635 | Yes |
| 1014 | 1953 | 1953.0 | 54.52 | 54.5 | The biology of interleukin-6. | T Kishimoto | Blood | 1989 | 2473791 | No |
| 1015 | 1953 | 1953.0 | 53.63 | 53.6 | Epidemiology of insomnia: what we know and what we still need to learn. | Maurice M Ohayon | Sleep Med Rev | 2002 | 12531146 | Yes |
| 1016 | 1952 | 1952.0 | 35.5 | 35.5 | ATM and related protein kinases: safeguarding genome integrity. | Yosef Shiloh | Nat Rev Cancer | 2003 | 12612651 | No |
| 1017 | 17567 | 1951.9 | 1014.55 | 112.7 | Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. | Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray | Int J Cancer | 2015 | 25220842 | Yes |
| 1018 | 3900 | 1950.0 | 79.5 | 39.8 | Network biology: understanding the cell's functional organization. | Albert-László Barabási, Zoltán N Oltvai | Nat Rev Genet | 2004 | 14735121 | No |
| 1019 | 3895 | 1947.5 | 91.91 | 46.0 | Brown adipose tissue: function and physiological significance. | Barbara Cannon, Jan Nedergaard | Physiol Rev | 2004 | 14715917 | No |
| 1020 | 1946 | 1946.0 | 0.0 | 0.0 | Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. | A Fleckenstein | Annu Rev Pharmacol Toxicol | 1977 | 326161 | No |
| 1021 | 1945 | 1945.0 | 0.0 | 0.0 | Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. | J P Chamberlain | Anal Biochem | 1979 | 543547 | Yes |
| 1022 | 3890 | 1945.0 | 85.07 | 42.5 | Lessons from hereditary colorectal cancer. | K W Kinzler, B Vogelstein | Cell | 1996 | 8861899 | No |
| 1023 | 1944 | 1944.0 | 36.0 | 36.0 | In situ hybridization: an improved whole-mount method for Xenopus embryos. | R M Harland | Methods Cell Biol | 1991 | 1811161 | Yes |
| 1024 | 1943 | 1943.0 | 65.66 | 65.7 | Keratoconus. | Y S Rabinowitz | Surv Ophthalmol | 1998 | 9493273 | No |
| 1025 | 3885 | 1942.5 | 0.0 | 0.0 | Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. | I W McLean, P K Nakane | J Histochem Cytochem | 1974 | 4374474 | Yes |
| 1026 | 5827 | 1942.3 | 195.83 | 65.3 | Parallel organization of functionally segregated circuits linking basal ganglia and cortex. | G E Alexander, M R DeLong, P L Strick | Annu Rev Neurosci | 1986 | 3085570 | No |
| 1027 | 7766 | 1941.5 | 199.09 | 49.8 | Matrix elasticity directs stem cell lineage specification. | Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E Discher | Cell | 2006 | 16923388 | Yes |
| 1028 | 3882 | 1941.0 | 85.22 | 42.6 | The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. | A J Ridley, A Hall | Cell | 1992 | 1643657 | Yes |
| 1029 | 1940 | 1940.0 | 58.16 | 58.2 | Intracellular calcium homeostasis. | E Carafoli | Annu Rev Biochem | 1987 | 3304139 | No |
| 1030 | 1940 | 1940.0 | 39.33 | 39.3 | CpG motifs in bacterial DNA and their immune effects. | Arthur M Krieg | Annu Rev Immunol | 2002 | 11861616 | No |
| 1031 | 1939 | 1939.0 | 77.67 | 77.7 | Approximate entropy as a measure of system complexity. | S M Pincus | Proc Natl Acad Sci U S A | 1991 | 11607165 | Yes |
| 1032 | 5816 | 1938.7 | 224.65 | 74.9 | Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. | G Muyzer, E C de Waal, A G Uitterlinden | Appl Environ Microbiol | 1993 | 7683183 | Yes |
| 1033 | 3875 | 1937.5 | 0.0 | 0.0 | A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. | R F Beers, I W Sizer | J Biol Chem | 1952 | 14938361 | Yes |
| 1034 | 1936 | 1936.0 | 84.09 | 84.1 | Role of nrf2 in oxidative stress and toxicity. | Qiang Ma | Annu Rev Pharmacol Toxicol | 2013 | 23294312 | No |
| 1035 | 1935 | 1935.0 | 44.9 | 44.9 | A clearer vision for in vivo imaging. | R Weissleder | Nat Biotechnol | 2001 | 11283581 | No |
| 1036 | 3868 | 1934.0 | 0.0 | 0.0 | Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. | A C Chang, S N Cohen | J Bacteriol | 1978 | 149110 | Yes |
| 1037 | 3868 | 1934.0 | 108.0 | 54.0 | Insulin-like growth factors and their binding proteins: biological actions. | J I Jones, D R Clemmons | Endocr Rev | 1995 | 7758431 | No |
| 1038 | 1933 | 1933.0 | 47.39 | 47.4 | Animal mitochondrial genomes. | J L Boore | Nucleic Acids Res | 1999 | 10101183 | No |
| 1039 | 1932 | 1932.0 | 0.0 | 0.0 | Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? | J V Neel | Am J Hum Genet | 1962 | 13937884 | Yes |
| 1040 | 3861 | 1930.5 | 0.0 | 0.0 | Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. | W R Morrison, L M Smith | J Lipid Res | 1964 | 14221106 | Yes |
| 1041 | 1929 | 1929.0 | 81.66 | 81.7 | A rating scale for drug-induced akathisia. | T R Barnes | Br J Psychiatry | 1989 | 2574607 | Yes |
| 1042 | 1927 | 1927.0 | 65.23 | 65.2 | Intermediate filaments as mechanical integrators of cellular space. | E Lazarides | Nature | 1980 | 7188712 | Yes |
| 1043 | 1927 | 1927.0 | 40.58 | 40.6 | Metastasis to bone: causes, consequences and therapeutic opportunities. | Gregory R Mundy | Nat Rev Cancer | 2002 | 12154351 | No |
| 1044 | 1927 | 1927.0 | 0.0 | 0.0 | Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. | M Kunitz | J Gen Physiol | 1947 | 19873496 | Yes |
| 1045 | 1925 | 1925.0 | 40.65 | 40.6 | Molecular bases for circadian clocks. | J C Dunlap | Cell | 1999 | 9988221 | No |
| 1046 | 3849 | 1924.5 | 95.31 | 47.7 | Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. | M Nei, T Gojobori | Mol Biol Evol | 1986 | 3444411 | Yes |
| 1047 | 1922 | 1922.0 | 40.62 | 40.6 | A cell culture model for T lymphocyte clonal anergy. | R H Schwartz | Science | 1990 | 2113314 | Yes |
| 1048 | 1922 | 1922.0 | 43.98 | 44.0 | Defensins: antimicrobial peptides of innate immunity. | Tomas Ganz | Nat Rev Immunol | 2003 | 12949495 | No |
| 1049 | 1922 | 1922.0 | 58.67 | 58.7 | Hazards of heavy metal contamination. | Lars Järup | Br Med Bull | 2003 | 14757716 | No |
| 1050 | 1921 | 1921.0 | 42.18 | 42.2 | The mitogen-activated protein kinase signal transduction pathway. | R J Davis | J Biol Chem | 1993 | 8325833 | No |
| 1051 | 1920 | 1920.0 | 0.0 | 0.0 | Influences of glucose loading and of injected insulin on hepatic glucose output. | R Steele | Ann N Y Acad Sci | 1959 | 13833973 | Yes |
| 1052 | 1917 | 1917.0 | 43.04 | 43.0 | Biology of natural killer cells. | G Trinchieri | Adv Immunol | 1989 | 2683611 | No |
| 1053 | 7667 | 1916.8 | 256.27 | 64.1 | clusterProfiler: an R package for comparing biological themes among gene clusters. | Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu He | OMICS | 2012 | 22455463 | Yes |
| 1054 | 3830 | 1915.0 | 96.29 | 48.1 | Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. | P J Barnes, M Karin | N Engl J Med | 1997 | 9091804 | No |
| 1055 | 1915 | 1915.0 | 50.52 | 50.5 | A theory of cortical responses. | Karl Friston | Philos Trans R Soc Lond B Biol Sci | 2005 | 15937014 | No |
| 1056 | 3829 | 1914.5 | 78.68 | 39.3 | Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. | Rudolf Jaenisch, Adrian Bird | Nat Genet | 2003 | 12610534 | No |
| 1057 | 3829 | 1914.5 | 78.57 | 39.3 | Smad-dependent and Smad-independent pathways in TGF-beta family signalling. | Rik Derynck, Ying E Zhang | Nature | 2003 | 14534577 | No |
| 1058 | 3825 | 1912.5 | 103.72 | 51.9 | Inositol phosphates and cell signalling. | M J Berridge, R F Irvine | Nature | 1989 | 2550825 | No |
| 1059 | 1912 | 1912.0 | 51.18 | 51.2 | DNA topoisomerase poisons as antitumor drugs. | L F Liu | Annu Rev Biochem | 1989 | 2549853 | No |
| 1060 | 1912 | 1912.0 | 47.31 | 47.3 | DNA topoisomerases. | J C Wang | Annu Rev Biochem | 1985 | 2992360 | No |
| 1061 | 1912 | 1912.0 | 43.47 | 43.5 | Signal sequences. The limits of variation. | G von Heijne | J Mol Biol | 1985 | 4032478 | Yes |
| 1062 | 1912 | 1912.0 | 0.0 | 0.0 | Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. | A Breslow | Ann Surg | 1970 | 5477666 | Yes |
| 1063 | 3824 | 1912.0 | 97.58 | 48.8 | Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. | Michael T Lin, M Flint Beal | Nature | 2006 | 17051205 | No |
| 1064 | 1908 | 1908.0 | 0.0 | 0.0 | On estimating the relation between blood group and disease. | B Woolf | Ann Hum Genet | 1955 | 14388528 | Yes |
| 1065 | 1905 | 1905.0 | 55.32 | 55.3 | Excitotoxic cell death. | D W Choi | J Neurobiol | 1992 | 1361523 | No |
| 1066 | 1905 | 1905.0 | 50.39 | 50.4 | Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. | R D Pascual-Marqui | Methods Find Exp Clin Pharmacol | 2002 | 12575463 | No |
| 1067 | 3809 | 1904.5 | 90.04 | 45.0 | Base-calling of automated sequencer traces using phred. II. Error probabilities. | B Ewing, P Green | Genome Res | 1998 | 9521922 | Yes |
| 1068 | 3809 | 1904.5 | 0.0 | 0.0 | Acetylornithinase of Escherichia coli: partial purification and some properties. | H J Vogel, D M Bonner | J Biol Chem | 1956 | 13278318 | Yes |
| 1069 | 1902 | 1902.0 | 0.0 | 0.0 | A modified card sorting test sensitive to frontal lobe defects. | H E Nelson | Cortex | 1976 | 1009768 | Yes |
| 1070 | 3803 | 1901.5 | 97.12 | 48.6 | Leptin and the regulation of body weight in mammals. | J M Friedman, J L Halaas | Nature | 1998 | 9796811 | No |
| 1071 | 1900 | 1900.0 | 42.2 | 42.2 | Theta oscillations in the hippocampus. | György Buzsáki | Neuron | 2002 | 11832222 | No |
| 1072 | 1900 | 1900.0 | 0.0 | 0.0 | The oxidation of ribonuclease with performic acid. | C H Hirs | J Biol Chem | 1956 | 13319283 | Yes |
| 1073 | 5697 | 1899.0 | 143.87 | 48.0 | GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. | R A Jefferson, T A Kavanagh, M W Bevan | EMBO J | 1987 | 3327686 | Yes |
| 1074 | 1899 | 1899.0 | 34.87 | 34.9 | Signaling--2000 and beyond. | T Hunter | Cell | 2000 | 10647936 | No |
| 1075 | 3796 | 1898.0 | 172.55 | 86.3 | The Health Belief Model: a decade later. | N K Janz, M H Becker | Health Educ Q | 1984 | 6392204 | No |
| 1076 | 1897 | 1897.0 | 0.0 | 0.0 | In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. | T R Chen | Exp Cell Res | 1977 | 65285 | Yes |
| 1077 | 1897 | 1897.0 | 84.42 | 84.4 | Brain dopamine receptors. | P Seeman | Pharmacol Rev | 1980 | 6117090 | No |
| 1078 | 1896 | 1896.0 | 57.15 | 57.1 | Calbindin D-28k and parvalbumin in the rat nervous system. | M R Celio | Neuroscience | 1990 | 2199841 | Yes |
| 1079 | 1895 | 1895.0 | 48.99 | 49.0 | Flow-mediated endothelial mechanotransduction. | P F Davies | Physiol Rev | 1995 | 7624393 | No |
| 1080 | 1895 | 1895.0 | 39.67 | 39.7 | The expanding role of mitochondria in apoptosis. | X Wang | Genes Dev | 2001 | 11711427 | No |
| 1081 | 3790 | 1895.0 | 77.34 | 38.7 | The Wnt signaling pathway in development and disease. | Catriona Y Logan, Roel Nusse | Annu Rev Cell Dev Biol | 2004 | 15473860 | No |
| 1082 | 3789 | 1894.5 | 96.22 | 48.1 | Cutaneous wound healing. | A J Singer, R A Clark | N Engl J Med | 1999 | 10471461 | No |
| 1083 | 1894 | 1894.0 | 50.33 | 50.3 | Accurate description of van der Waals complexes by density functional theory including empirical corrections. | Stefan Grimme | J Comput Chem | 2004 | 15224390 | Yes |
| 1084 | 1892 | 1892.0 | 52.32 | 52.3 | The physiology of glucagon-like peptide 1. | Jens Juul Holst | Physiol Rev | 2007 | 17928588 | No |
| 1085 | 7553 | 1888.2 | 189.32 | 47.3 | p53 mutations in human cancers. | M Hollstein, D Sidransky, B Vogelstein, C C Harris | Science | 1991 | 1905840 | No |
| 1086 | 5661 | 1887.0 | 0.0 | 0.0 | Research diagnostic criteria: rationale and reliability. | R L Spitzer, J Endicott, E Robins | Arch Gen Psychiatry | 1978 | 655775 | Yes |
| 1087 | 1887 | 1887.0 | 59.87 | 59.9 | TGFβ signalling in context. | Joan Massagué | Nat Rev Mol Cell Biol | 2012 | 22992590 | No |
| 1088 | 1886 | 1886.0 | 0.0 | 0.0 | Complete nucleotide sequence of the Escherichia coli plasmid pBR322. | J G Sutcliffe | Cold Spring Harb Symp Quant Biol | 1979 | 383387 | Yes |
| 1089 | 3770 | 1885.0 | 0.0 | 0.0 | Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. | J G Rheinwald, H Green | Cell | 1975 | 1052771 | Yes |
| 1090 | 1884 | 1884.0 | 63.54 | 63.5 | The use of a plus-maze to measure anxiety in the mouse. | R G Lister | Psychopharmacology (Berl) | 1987 | 3110839 | Yes |
| 1091 | 3765 | 1882.5 | 0.0 | 0.0 | An efficient mRNA-dependent translation system from reticulocyte lysates. | H R Pelham, R J Jackson | Eur J Biochem | 1976 | 823012 | Yes |
| 1092 | 1882 | 1882.0 | 55.09 | 55.1 | Japanese Classification of Gastric Carcinoma - 2nd English Edition - | Japanese Gastric Cancer Association | Gastric Cancer | 1998 | 11957040 | Yes |
| 1093 | 1882 | 1882.0 | 47.85 | 47.9 | Dopamine, learning and motivation. | Roy A Wise | Nat Rev Neurosci | 2004 | 15152198 | No |
| 1094 | 5646 | 1882.0 | 179.49 | 59.8 | The brain's default network: anatomy, function, and relevance to disease. | Randy L Buckner, Jessica R Andrews-Hanna, Daniel L Schacter | Ann N Y Acad Sci | 2008 | 18400922 | No |
| 1095 | 3762 | 1881.0 | 122.9 | 61.5 | Oxygen toxicity, oxygen radicals, transition metals and disease. | B Halliwell, J M Gutteridge | Biochem J | 1984 | 6326753 | No |
| 1096 | 1881 | 1881.0 | 38.31 | 38.3 | Signalling pathways of the TNF superfamily: a double-edged sword. | Bharat B Aggarwal | Nat Rev Immunol | 2003 | 12949498 | No |
| 1097 | 1880 | 1880.0 | 74.07 | 74.1 | Doxil®--the first FDA-approved nano-drug: lessons learned. | Yechezkel Barenholz | J Control Release | 2012 | 22484195 | No |
| 1098 | 3758 | 1879.0 | 86.79 | 43.4 | The Fas death factor. | S Nagata, P Golstein | Science | 1995 | 7533326 | No |
| 1099 | 1878 | 1878.0 | 49.91 | 49.9 | Mechanisms of hepatic fibrogenesis. | Scott L Friedman | Gastroenterology | 2008 | 18471545 | No |
| 1100 | 3753 | 1876.5 | 88.93 | 44.5 | The acute respiratory distress syndrome. | L B Ware, M A Matthay | N Engl J Med | 2000 | 10793167 | No |
| 1101 | 3751 | 1875.5 | 0.0 | 0.0 | Polymyositis and dermatomyositis (first of two parts). | A Bohan, J B Peter | N Engl J Med | 1975 | 1090839 | No |
| 1102 | 3750 | 1875.0 | 108.62 | 54.3 | Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. | B J Marshall, J R Warren | Lancet | 1984 | 6145023 | Yes |
| 1103 | 5625 | 1875.0 | 184.25 | 61.4 | FastTree 2--approximately maximum-likelihood trees for large alignments. | Morgan N Price, Paramvir S Dehal, Adam P Arkin | PLoS One | 2010 | 20224823 | Yes |
| 1104 | 5619 | 1873.0 | 118.89 | 39.6 | EMBOSS: the European Molecular Biology Open Software Suite. | P Rice, I Longden, A Bleasby | Trends Genet | 2000 | 10827456 | Yes |
| 1105 | 1869 | 1869.0 | 33.96 | 34.0 | The regulation of E2F by pRB-family proteins. | N Dyson | Genes Dev | 1998 | 9694791 | No |
| 1106 | 3738 | 1869.0 | 105.99 | 53.0 | Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. | Kresse, Hafner | Phys Rev B Condens Matter | 1994 | 10010505 | Yes |
| 1107 | 3733 | 1866.5 | 141.65 | 70.8 | The biofilm matrix. | Hans-Curt Flemming, Jost Wingender | Nat Rev Microbiol | 2010 | 20676145 | No |
| 1108 | 7461 | 1865.2 | 250.12 | 62.5 | Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. | A J Hughes, S E Daniel, L Kilford, A J Lees | J Neurol Neurosurg Psychiatry | 1992 | 1564476 | Yes |
| 1109 | 1865 | 1865.0 | 45.99 | 46.0 | Thioredoxin. | A Holmgren | Annu Rev Biochem | 1985 | 3896121 | No |
| 1110 | 5591 | 1863.7 | 181.61 | 60.5 | Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. | C Lord, M Rutter, A Le Couteur | J Autism Dev Disord | 1994 | 7814313 | Yes |
| 1111 | 5590 | 1863.3 | 160.4 | 53.5 | Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. | F E Harrell, K L Lee, D B Mark | Stat Med | 1996 | 8668867 | No |
| 1112 | 1862 | 1862.0 | 57.56 | 57.6 | Social determinants of health inequalities. | Michael Marmot | Lancet | 2005 | 15781105 | Yes |
| 1113 | 3722 | 1861.0 | 80.38 | 40.2 | Raster3D: photorealistic molecular graphics. | E A Merritt, D J Bacon | Methods Enzymol | 1997 | 18488322 | Yes |
| 1114 | 1861 | 1861.0 | 52.55 | 52.5 | Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. | Gökhan S Hotamisligil | Cell | 2010 | 20303879 | No |
| 1115 | 1859 | 1859.0 | 0.0 | 0.0 | Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. | D M Neville | J Biol Chem | 1971 | 5127429 | Yes |
| 1116 | 1859 | 1859.0 | 50.67 | 50.7 | The extracellular matrix: not just pretty fibrils. | Richard O Hynes | Science | 2009 | 19965464 | No |
| 1117 | 3717 | 1858.5 | 84.88 | 42.4 | Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. | T Miyashita, J C Reed | Cell | 1995 | 7834749 | Yes |
| 1118 | 3713 | 1856.5 | 113.68 | 56.8 | Nonparametric statistical testing of EEG- and MEG-data. | Eric Maris, Robert Oostenveld | J Neurosci Methods | 2007 | 17517438 | Yes |
| 1119 | 1856 | 1856.0 | 37.61 | 37.6 | Antiviral actions of interferons. | C E Samuel | Clin Microbiol Rev | 2001 | 11585785 | No |
| 1120 | 1853 | 1853.0 | 46.23 | 46.2 | DAMPs, PAMPs and alarmins: all we need to know about danger. | Marco E Bianchi | J Leukoc Biol | 2007 | 17032697 | No |
| 1121 | 9255 | 1851.0 | 979.79 | 196.0 | MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. | Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro Tamura | Mol Biol Evol | 2018 | 29722887 | Yes |
| 1122 | 1849 | 1849.0 | 0.0 | 0.0 | The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. | G S Manning | Q Rev Biophys | 1978 | 353876 | No |
| 1123 | 1849 | 1849.0 | 54.04 | 54.0 | The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. | G P Chrousos | N Engl J Med | 1995 | 7715646 | No |
| 1124 | 1849 | 1849.0 | 37.33 | 37.3 | Systems biology: a brief overview. | Hiroaki Kitano | Science | 2002 | 11872829 | No |
| 1125 | 3697 | 1848.5 | 72.81 | 36.4 | Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. | M Karin, Y Ben-Neriah | Annu Rev Immunol | 2000 | 10837071 | No |
| 1126 | 1848 | 1848.0 | 90.25 | 90.2 | Performance-oriented assessment of mobility problems in elderly patients. | M E Tinetti | J Am Geriatr Soc | 1986 | 3944402 | Yes |
| 1127 | 1848 | 1848.0 | 39.58 | 39.6 | Thrombin signalling and protease-activated receptors. | S R Coughlin | Nature | 2000 | 11001069 | No |
| 1128 | 1848 | 1848.0 | 37.78 | 37.8 | DNA topoisomerases: structure, function, and mechanism. | J J Champoux | Annu Rev Biochem | 2001 | 11395412 | No |
| 1129 | 1845 | 1845.0 | 40.44 | 40.4 | The immunopathogenesis of sepsis. | Jonathan Cohen | Nature | 2002 | 12490963 | No |
| 1130 | 5533 | 1844.3 | 0.0 | 0.0 | A rapid method for the isolation of functional thymus-derived murine lymphocytes. | M H Julius, E Simpson, L A Herzenberg | Eur J Immunol | 1973 | 4587740 | Yes |
| 1131 | 3688 | 1844.0 | 0.0 | 0.0 | Immunoassay of insulin with insulin-antibody precipitate. | C N Hales, P J Randle | Biochem J | 1963 | 13952078 | Yes |
| 1132 | 3687 | 1843.5 | 89.88 | 44.9 | The future of genetic studies of complex human diseases. | N Risch, K Merikangas | Science | 1996 | 8801636 | Yes |
| 1133 | 1843 | 1843.0 | 49.08 | 49.1 | Hepatitis B virus infection. | W M Lee | N Engl J Med | 1997 | 9392700 | No |
| 1134 | 1843 | 1843.0 | 47.44 | 47.4 | Negative refraction makes a perfect lens | Pendry | Phys Rev Lett | 2000 | 11041972 | Yes |
| 1135 | 3685 | 1842.5 | 164.93 | 82.5 | The Brief Symptom Inventory: an introductory report. | L R Derogatis, N Melisaratos | Psychol Med | 1983 | 6622612 | Yes |
| 1136 | 5523 | 1841.0 | 178.18 | 59.4 | Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. | R L Spitzer, K Kroenke, J B Williams | JAMA | 1999 | 10568646 | Yes |
| 1137 | 5521 | 1840.3 | 136.21 | 45.4 | APE: Analyses of Phylogenetics and Evolution in R language. | Emmanuel Paradis, Julien Claude, Korbinian Strimmer | Bioinformatics | 2004 | 14734327 | Yes |
| 1138 | 1840 | 1840.0 | 46.11 | 46.1 | Cancer chemoprevention with dietary phytochemicals. | Young-Joon Surh | Nat Rev Cancer | 2003 | 14570043 | No |
| 1139 | 3679 | 1839.5 | 94.68 | 47.3 | The endophenotype concept in psychiatry: etymology and strategic intentions. | Irving I Gottesman, Todd D Gould | Am J Psychiatry | 2003 | 12668349 | No |
| 1140 | 7355 | 1838.8 | 256.7 | 64.2 | Reporting results of cancer treatment. | A B Miller, B Hoogstraten, M Staquet, A Winkler | Cancer | 1981 | 7459811 | Yes |
| 1141 | 1838 | 1838.0 | 40.42 | 40.4 | TRP channels as cellular sensors. | David E Clapham | Nature | 2003 | 14654832 | No |
| 1142 | 1837 | 1837.0 | 0.0 | 0.0 | A simple fluorometric assay for lipoperoxide in blood plasma. | K Yagi | Biochem Med | 1976 | 962904 | Yes |
| 1143 | 7344 | 1836.0 | 155.79 | 38.9 | WebLogo: a sequence logo generator. | Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E Brenner | Genome Res | 2004 | 15173120 | Yes |
| 1144 | 7332 | 1833.0 | 281.02 | 70.3 | The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. | T F Heatherton, L T Kozlowski, R C Frecker, K O Fagerström | Br J Addict | 1991 | 1932883 | Yes |
| 1145 | 1832 | 1832.0 | 0.0 | 0.0 | Comparison of the predicted and observed secondary structure of T4 phage lysozyme. | B W Matthews | Biochim Biophys Acta | 1975 | 1180967 | Yes |
| 1146 | 7323 | 1830.8 | 0.0 | 0.0 | Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. | D J Sahn, A DeMaria, J Kisslo, A Weyman | Circulation | 1978 | 709763 | Yes |
| 1147 | 1830 | 1830.0 | 46.78 | 46.8 | Drug-like properties and the causes of poor solubility and poor permeability. | C A Lipinski | J Pharmacol Toxicol Methods | 2000 | 11274893 | No |
| 1148 | 3659 | 1829.5 | 92.11 | 46.1 | Measuring the thickness of the human cerebral cortex from magnetic resonance images. | B Fischl, A M Dale | Proc Natl Acad Sci U S A | 2000 | 10984517 | Yes |
| 1149 | 5488 | 1829.3 | 181.92 | 60.6 | AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. | P G Reeves, F H Nielsen, G C Fahey | J Nutr | 1993 | 8229312 | No |
| 1150 | 1827 | 1827.0 | 68.35 | 68.3 | Physiological aspects of primary hypertension. | B Folkow | Physiol Rev | 1982 | 6461865 | No |
| 1151 | 1826 | 1826.0 | 59.55 | 59.5 | Sick individuals and sick populations. | G Rose | Int J Epidemiol | 1985 | 3872850 | Yes |
| 1152 | 1826 | 1826.0 | 53.71 | 53.7 | Intestinal mucosal barrier function in health and disease. | Jerrold R Turner | Nat Rev Immunol | 2009 | 19855405 | No |
| 1153 | 1825 | 1825.0 | 57.34 | 57.3 | The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. | B L Fredrickson | Am Psychol | 2001 | 11315248 | Yes |
| 1154 | 14592 | 1824.0 | 414.99 | 51.9 | Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. | R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A Erlich | Science | 1988 | 2448875 | Yes |
| 1155 | 1824 | 1824.0 | 45.42 | 45.4 | The global health burden of infection-associated cancers in the year 2002. | Donald Maxwell Parkin | Int J Cancer | 2006 | 16404738 | Yes |
| 1156 | 1823 | 1823.0 | 61.41 | 61.4 | Physiological actions of taurine. | R J Huxtable | Physiol Rev | 1992 | 1731369 | No |
| 1157 | 1822 | 1822.0 | 38.97 | 39.0 | The complex language of chromatin regulation during transcription. | Shelley L Berger | Nature | 2007 | 17522673 | No |
| 1158 | 1821 | 1821.0 | 0.0 | 0.0 | High-speed scanning in human memory. | S Sternberg | Science | 1966 | 5939936 | Yes |
| 1159 | 1820 | 1820.0 | 0.0 | 0.0 | A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. | D A Robinson | IEEE Trans Biomed Eng | 1963 | 14121113 | Yes |
| 1160 | 1819 | 1819.0 | 43.99 | 44.0 | Metabolomics--the link between genotypes and phenotypes. | Oliver Fiehn | Plant Mol Biol | 2002 | 11860207 | No |
| 1161 | 3637 | 1818.5 | 0.0 | 0.0 | Mathematical model for studying genetic variation in terms of restriction endonucleases. | M Nei, W H Li | Proc Natl Acad Sci U S A | 1979 | 291943 | Yes |
| 1162 | 1816 | 1816.0 | 98.92 | 98.9 | The assessment of clinical skills/competence/performance. | G E Miller | Acad Med | 1990 | 2400509 | Yes |
| 1163 | 5446 | 1815.3 | 137.73 | 45.9 | Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. | Z N Oltvai, C L Milliman, S J Korsmeyer | Cell | 1993 | 8358790 | Yes |
| 1164 | 7260 | 1815.0 | 0.0 | 0.0 | Antibiotic susceptibility testing by a standardized single disk method. | A W Bauer, W M Kirby, J C Sherris, M Turck | Am J Clin Pathol | 1966 | 5325707 | Yes |
| 1165 | 1815 | 1815.0 | 41.03 | 41.0 | Cellular mechanisms of insulin resistance. | G I Shulman | J Clin Invest | 2000 | 10903330 | No |
| 1166 | 1814 | 1814.0 | 50.25 | 50.2 | A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. | P J Goodford | J Med Chem | 1985 | 3892003 | Yes |
| 1167 | 1813 | 1813.0 | 46.57 | 46.6 | Interfaces and the driving force of hydrophobic assembly. | David Chandler | Nature | 2005 | 16193038 | No |
| 1168 | 1812 | 1812.0 | 0.0 | 0.0 | A theory of cerebellar cortex. | D Marr | J Physiol | 1969 | 5784296 | Yes |
| 1169 | 1812 | 1812.0 | 59.22 | 59.2 | Health consequences of intimate partner violence. | Jacquelyn C Campbell | Lancet | 2002 | 11965295 | No |
| 1170 | 1812 | 1812.0 | 52.51 | 52.5 | MYC on the path to cancer. | Chi V Dang | Cell | 2012 | 22464321 | No |
| 1171 | 1811 | 1811.0 | 33.24 | 33.2 | Mechanisms of alternative pre-messenger RNA splicing. | Douglas L Black | Annu Rev Biochem | 2003 | 12626338 | No |
| 1172 | 5430 | 1810.0 | 125.78 | 41.9 | A new statistical method for haplotype reconstruction from population data. | M Stephens, N J Smith, P Donnelly | Am J Hum Genet | 2001 | 11254454 | Yes |
| 1173 | 1809 | 1809.0 | 52.13 | 52.1 | Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. | A Dunaif | Endocr Rev | 1997 | 9408743 | No |
| 1174 | 5425 | 1808.3 | 105.43 | 35.1 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. | Jason D Fontenot, Marc A Gavin, Alexander Y Rudensky | Nat Immunol | 2003 | 12612578 | Yes |
| 1175 | 1808 | 1808.0 | 105.22 | 105.2 | Determination and quantification of content validity. | M R Lynn | Nurs Res | 1986 | 3640358 | Yes |
| 1176 | 1808 | 1808.0 | 41.49 | 41.5 | DNA topoisomerases. | J C Wang | Annu Rev Biochem | 1996 | 8811192 | No |
| 1177 | 7229 | 1807.2 | 286.49 | 71.6 | A simple technique for quantitation of low levels of DNA damage in individual cells. | N P Singh, M T McCoy, R R Tice, E L Schneider | Exp Cell Res | 1988 | 3345800 | Yes |
| 1178 | 1807 | 1807.0 | 40.48 | 40.5 | A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. | J SantaLucia | Proc Natl Acad Sci U S A | 1998 | 9465037 | Yes |
| 1179 | 1807 | 1807.0 | 46.7 | 46.7 | Follicular helper CD4 T cells (TFH). | Shane Crotty | Annu Rev Immunol | 2011 | 21314428 | No |
| 1180 | 1805 | 1805.0 | 0.0 | 0.0 | A classification of hand preference by association analysis. | M Annett | Br J Psychol | 1970 | 5457503 | Yes |
| 1181 | 1804 | 1804.0 | 35.66 | 35.7 | Approaching the asymptote? Evolution and revolution in immunology. | C A Janeway | Cold Spring Harb Symp Quant Biol | 1989 | 2700931 | No |
| 1182 | 3607 | 1803.5 | 125.22 | 62.6 | Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. | M H Zweig, G Campbell | Clin Chem | 1993 | 8472349 | No |
| 1183 | 1802 | 1802.0 | 42.02 | 42.0 | Global cancer statistics in the year 2000. | D M Parkin | Lancet Oncol | 2001 | 11905707 | No |
| 1184 | 1802 | 1802.0 | 50.99 | 51.0 | Biofilms: microbial life on surfaces. | Rodney M Donlan | Emerg Infect Dis | 2002 | 12194761 | No |
| 1185 | 1801 | 1801.0 | 0.0 | 0.0 | The etiology of chondromalacia patellae. | R E Outerbridge | J Bone Joint Surg Br | 1961 | 14038135 | Yes |
| 1186 | 1800 | 1800.0 | 68.07 | 68.1 | Recognition-by-components: a theory of human image understanding. | Irving Biederman | Psychol Rev | 1987 | 3575582 | Yes |
| 1187 | 1800 | 1800.0 | 0.0 | 0.0 | On respiratory impairment in cancer cells. | O Warburg | Science | 1956 | 13351639 | Yes |
| 1188 | 3599 | 1799.5 | 120.29 | 60.1 | Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. | R A DeFronzo, E Ferrannini | Diabetes Care | 1991 | 2044434 | No |
| 1189 | 7193 | 1798.2 | 287.59 | 71.9 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | J Clin Epidemiol | 2009 | 19631508 | No |
| 1190 | 3596 | 1798.0 | 123.35 | 61.7 | Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. | G Di Chiara, A Imperato | Proc Natl Acad Sci U S A | 1988 | 2899326 | Yes |
| 1191 | 1798 | 1798.0 | 39.5 | 39.5 | Developmental regulation of the growth plate. | Henry M Kronenberg | Nature | 2003 | 12748651 | No |
| 1192 | 1798 | 1798.0 | 0.0 | 0.0 | Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. | S Cohen | J Biol Chem | 1962 | 13880319 | Yes |
| 1193 | 1797 | 1797.0 | 37.01 | 37.0 | Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. | R J Kaufman | Genes Dev | 1999 | 10346810 | No |
| 1194 | 12574 | 1796.3 | 287.16 | 41.0 | Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. | Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman | Genome Biol | 2002 | 12184808 | Yes |
| 1195 | 1796 | 1796.0 | 43.63 | 43.6 | The mitochondrial permeability transition pore and its role in cell death. | M Crompton | Biochem J | 1999 | 10393078 | No |
| 1196 | 1796 | 1796.0 | 43.07 | 43.1 | Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. | B L Wajchenberg | Endocr Rev | 2000 | 11133069 | No |
| 1197 | 7178 | 1794.5 | 177.12 | 44.3 | Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. | A Shevchenko, M Wilm, O Vorm, M Mann | Anal Chem | 1996 | 8779443 | Yes |
| 1198 | 3588 | 1794.0 | 75.03 | 37.5 | Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. | C D Nobes, A Hall | Cell | 1995 | 7536630 | Yes |
| 1199 | 1794 | 1794.0 | 45.82 | 45.8 | The hydrogen bond in the solid state. | Thomas Steiner | Angew Chem Int Ed Engl | 2002 | 12491444 | Yes |
| 1200 | 1793 | 1793.0 | 66.05 | 66.0 | Why patients use alternative medicine: results of a national study. | J A Astin | JAMA | 1998 | 9605899 | Yes |
| 1201 | 1793 | 1793.0 | 44.57 | 44.6 | The dawning era of polymer therapeutics. | Ruth Duncan | Nat Rev Drug Discov | 2003 | 12750738 | No |
| 1202 | 1792 | 1792.0 | 56.52 | 56.5 | PsychoPy--Psychophysics software in Python. | Jonathan W Peirce | J Neurosci Methods | 2007 | 17254636 | Yes |
| 1203 | 3583 | 1791.5 | 157.02 | 78.5 | The MOS social support survey. | C D Sherbourne, A L Stewart | Soc Sci Med | 1991 | 2035047 | Yes |
| 1204 | 1788 | 1788.0 | 40.3 | 40.3 | The distribution of secondary growths in cancer of the breast. 1889. | S Paget | Cancer Metastasis Rev | 1989 | 2673568 | No |
| 1205 | 1788 | 1788.0 | 0.0 | 0.0 | The measurement of volume changes in human limbs. | R J Whitney | J Physiol | 1953 | 13085295 | Yes |
| 1206 | 1787 | 1787.0 | 58.95 | 59.0 | Heavy metal intensification of DAB-based HRP reaction product. | J C Adams | J Histochem Cytochem | 1981 | 7252134 | Yes |
| 1207 | 1787 | 1787.0 | 0.0 | 0.0 | The influence of some cations on an adenosine triphosphatase from peripheral nerves. | J C Skou | Biochim Biophys Acta | 1957 | 13412736 | Yes |
| 1208 | 1787 | 1787.0 | 41.11 | 41.1 | Neutrophils and immunity: challenges and opportunities. | Carl Nathan | Nat Rev Immunol | 2006 | 16498448 | No |
| 1209 | 1786 | 1786.0 | 61.51 | 61.5 | Guided Search 2.0 A revised model of visual search. | J M Wolfe | Psychon Bull Rev | 1994 | 24203471 | Yes |
| 1210 | 1785 | 1785.0 | 0.0 | 0.0 | Estimability and estimation in case-referent studies. | O Miettinen | Am J Epidemiol | 1976 | 1251836 | Yes |
| 1211 | 1785 | 1785.0 | 45.59 | 45.6 | Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. | Fiona Turnbull | Lancet | 2003 | 14615107 | Yes |
| 1212 | 1784 | 1784.0 | 58.03 | 58.0 | Calculation of substrate oxidation rates in vivo from gaseous exchange. | K N Frayn | J Appl Physiol Respir Environ Exerc Physiol | 1983 | 6618956 | Yes |
| 1213 | 1779 | 1779.0 | 48.25 | 48.2 | Network pharmacology: the next paradigm in drug discovery. | Andrew L Hopkins | Nat Chem Biol | 2008 | 18936753 | No |
| 1214 | 3557 | 1778.5 | 0.0 | 0.0 | Maturation of the head of bacteriophage T4. I. DNA packaging events. | U K Laemmli, M Favre | J Mol Biol | 1973 | 4204102 | Yes |
| 1215 | 7114 | 1778.5 | 175.62 | 43.9 | Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. | C A Lipinski, F Lombardo, B W Dominy, P J Feeney | Adv Drug Deliv Rev | 2001 | 11259830 | No |
| 1216 | 1778 | 1778.0 | 0.0 | 0.0 | Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4332693 | Yes |
| 1217 | 3555 | 1777.5 | 0.0 | 0.0 | Multiple receptors for dopamine. | J W Kebabian, D B Calne | Nature | 1979 | 215920 | No |
| 1218 | 1773 | 1773.0 | 0.0 | 0.0 | Protein denaturation. | C Tanford | Adv Protein Chem | 1968 | 4882248 | No |
| 1219 | 3544 | 1772.0 | 93.8 | 46.9 | Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. | K D McCarthy, J de Vellis | J Cell Biol | 1980 | 6248568 | Yes |
| 1220 | 3543 | 1771.5 | 113.57 | 56.8 | Efficient pseudopotentials for plane-wave calculations. | Troullier, Martins | Phys Rev B Condens Matter | 1991 | 9997467 | Yes |
| 1221 | 5313 | 1771.0 | 176.26 | 58.8 | Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. | L Excoffier, P E Smouse, J M Quattro | Genetics | 1992 | 1644282 | Yes |
| 1222 | 1771 | 1771.0 | 58.55 | 58.5 | Epidemiological features of chronic low-back pain. | G B Andersson | Lancet | 1999 | 10470716 | No |
| 1223 | 1771 | 1771.0 | 43.38 | 43.4 | Targeting PI3K signalling in cancer: opportunities, challenges and limitations. | Jeffrey A Engelman | Nat Rev Cancer | 2009 | 19629070 | No |
| 1224 | 3541 | 1770.5 | 86.24 | 43.1 | Protein folding in the cell. | M J Gething, J Sambrook | Nature | 1992 | 1731198 | No |
| 1225 | 1770 | 1770.0 | 72.14 | 72.1 | Perception of risk. | P Slovic | Science | 1987 | 3563507 | Yes |
| 1226 | 3540 | 1770.0 | 67.05 | 33.5 | Rho GTPases in cell biology. | Sandrine Etienne-Manneville, Alan Hall | Nature | 2002 | 12478284 | No |
| 1227 | 1770 | 1770.0 | 48.15 | 48.1 | An index to quantify an individual's scientific research output. | J E Hirsch | Proc Natl Acad Sci U S A | 2005 | 16275915 | Yes |
| 1228 | 1770 | 1770.0 | 45.47 | 45.5 | Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. | Scott L Friedman | Physiol Rev | 2008 | 18195085 | No |
| 1229 | 1769 | 1769.0 | 0.0 | 0.0 | The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. | S Hestrin | J Biol Chem | 1949 | 18133390 | Yes |
| 1230 | 1768 | 1768.0 | 0.0 | 0.0 | Positional information and the spatial pattern of cellular differentiation. | L Wolpert | J Theor Biol | 1969 | 4390734 | Yes |
| 1231 | 1768 | 1768.0 | 0.0 | 0.0 | Transplacental carcinogenesis by stilbestrol. | J Folkman | N Engl J Med | 1971 | 5556579 | Yes |
| 1232 | 5301 | 1767.0 | 138.52 | 46.2 | Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. | G S Hotamisligil, N S Shargill, B M Spiegelman | Science | 1993 | 7678183 | Yes |
| 1233 | 1767 | 1767.0 | 35.37 | 35.4 | Notch signalling: a simple pathway becomes complex. | Sarah J Bray | Nat Rev Mol Cell Biol | 2006 | 16921404 | No |
| 1234 | 3531 | 1765.5 | 100.88 | 50.4 | The inflammasomes. | Kate Schroder, Jurg Tschopp | Cell | 2010 | 20303873 | No |
| 1235 | 1764 | 1764.0 | 49.56 | 49.6 | New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. | R Y Tsien | Biochemistry | 1980 | 6770893 | Yes |
| 1236 | 1762 | 1762.0 | 81.73 | 81.7 | Determinants of low birth weight: methodological assessment and meta-analysis. | M S Kramer | Bull World Health Organ | 1987 | 3322602 | No |
| 1237 | 1758 | 1758.0 | 48.11 | 48.1 | G proteins and dual control of adenylate cyclase. | A G Gilman | Cell | 1984 | 6321035 | Yes |
| 1238 | 1757 | 1757.0 | 62.28 | 62.3 | The role of hormone receptors and GTP-regulatory proteins in membrane transduction. | M Rodbell | Nature | 1980 | 6101906 | Yes |
| 1239 | 5271 | 1757.0 | 204.2 | 68.1 | Effect of the damping function in dispersion corrected density functional theory. | Stefan Grimme, Stephan Ehrlich, Lars Goerigk | J Comput Chem | 2011 | 21370243 | Yes |
| 1240 | 12298 | 1756.9 | 300.77 | 43.0 | Induction of pluripotent stem cells from adult human fibroblasts by defined factors. | Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka | Cell | 2007 | 18035408 | Yes |
| 1241 | 3511 | 1755.5 | 113.53 | 56.8 | Wnt/β-catenin signaling and disease. | Hans Clevers, Roel Nusse | Cell | 2012 | 22682243 | No |
| 1242 | 1755 | 1755.0 | 36.59 | 36.6 | An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. | R M Esnouf | J Mol Graph Model | 1997 | 9385560 | Yes |
| 1243 | 1754 | 1754.0 | 62.35 | 62.4 | A cortical network for directed attention and unilateral neglect. | M M Mesulam | Ann Neurol | 1981 | 7032417 | No |
| 1244 | 1754 | 1754.0 | 54.72 | 54.7 | An overview of brominated flame retardants in the environment. | Cynthia A de Wit | Chemosphere | 2002 | 11999784 | No |
| 1245 | 1751 | 1751.0 | 58.93 | 58.9 | Drugs of abuse: anatomy, pharmacology and function of reward pathways. | G F Koob | Trends Pharmacol Sci | 1992 | 1604710 | No |
| 1246 | 1749 | 1749.0 | 68.55 | 68.5 | Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. | H U Wittchen | J Psychiatr Res | 1994 | 8064641 | No |
| 1247 | 1749 | 1749.0 | 52.91 | 52.9 | Infrared spectroscopy of proteins. | Andreas Barth | Biochim Biophys Acta | 2007 | 17692815 | No |
| 1248 | 1748 | 1748.0 | 40.47 | 40.5 | Steroid receptor regulated transcription of specific genes and gene networks. | K R Yamamoto | Annu Rev Genet | 1985 | 3909942 | No |
| 1249 | 1747 | 1747.0 | 52.38 | 52.4 | Inhibited spontaneous emission in solid-state physics and electronics. | Yablonovitch | Phys Rev Lett | 1987 | 10034639 | Yes |
| 1250 | 1747 | 1747.0 | 50.84 | 50.8 | Flavonoids as antioxidants. | P G Pietta | J Nat Prod | 2000 | 10924197 | No |
| 1251 | 1747 | 1747.0 | 0.0 | 0.0 | A personality scale of manifest anxiety. | J A Taylor | J Abnorm Psychol | 1953 | 13052352 | Yes |
| 1252 | 3494 | 1747.0 | 76.14 | 38.1 | Cell death: critical control points. | Nika N Danial, Stanley J Korsmeyer | Cell | 2004 | 14744432 | No |
| 1253 | 1747 | 1747.0 | 36.44 | 36.4 | DNA methylation and human disease. | Keith D Robertson | Nat Rev Genet | 2005 | 16136652 | No |
| 1254 | 3494 | 1747.0 | 127.49 | 63.7 | Microenvironmental regulation of tumor progression and metastasis. | Daniela F Quail, Johanna A Joyce | Nat Med | 2013 | 24202395 | No |
| 1255 | 1746 | 1746.0 | 71.47 | 71.5 | The Resonating Valence Bond State in La2CuO4 and Superconductivity. | P W Anderson | Science | 1987 | 17818979 | Yes |
| 1256 | 1745 | 1745.0 | 46.0 | 46.0 | Using circular dichroism spectra to estimate protein secondary structure. | Norma J Greenfield | Nat Protoc | 2006 | 17406547 | Yes |
| 1257 | 1744 | 1744.0 | 45.04 | 45.0 | The pathophysiology of tumor necrosis factors. | P Vassalli | Annu Rev Immunol | 1992 | 1590993 | No |
| 1258 | 3486 | 1743.0 | 0.0 | 0.0 | A complementation analysis of the restriction and modification of DNA in Escherichia coli. | H W Boyer, D Roulland-Dussoix | J Mol Biol | 1969 | 4896022 | Yes |
| 1259 | 1742 | 1742.0 | 46.47 | 46.5 | Interleukin-6: an overview. | J Van Snick | Annu Rev Immunol | 1990 | 2188664 | No |
| 1260 | 3484 | 1742.0 | 97.51 | 48.8 | ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. | B Ravel, M Newville | J Synchrotron Radiat | 2005 | 15968136 | Yes |
| 1261 | 3482 | 1741.0 | 90.22 | 45.1 | Long short-term memory. | S Hochreiter, J Schmidhuber | Neural Comput | 1997 | 9377276 | Yes |
| 1262 | 1741 | 1741.0 | 36.2 | 36.2 | MicroRNA biogenesis: coordinated cropping and dicing. | V Narry Kim | Nat Rev Mol Cell Biol | 2005 | 15852042 | No |
| 1263 | 1739 | 1739.0 | 64.9 | 64.9 | Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. | D R Janero | Free Radic Biol Med | 1990 | 2079232 | No |
| 1264 | 1739 | 1739.0 | 36.95 | 37.0 | Mechanisms of cancer drug resistance. | Michael M Gottesman | Annu Rev Med | 2002 | 11818492 | No |
| 1265 | 3477 | 1738.5 | 93.06 | 46.5 | Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering | Nie, Emory | Science | 1997 | 9027306 | Yes |
| 1266 | 1738 | 1738.0 | 41.89 | 41.9 | Integrating cell-signalling pathways with NF-kappaB and IKK function. | Neil D Perkins | Nat Rev Mol Cell Biol | 2007 | 17183360 | No |
| 1267 | 1737 | 1737.0 | 0.0 | 0.0 | Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. | M J Casadaban | J Mol Biol | 1976 | 781293 | Yes |
| 1268 | 3473 | 1736.5 | 92.31 | 46.2 | A scaling normalization method for differential expression analysis of RNA-seq data. | Mark D Robinson, Alicia Oshlack | Genome Biol | 2010 | 20196867 | Yes |
| 1269 | 1736 | 1736.0 | 0.0 | 0.0 | Dendritic organization in the neurons of the visual and motor cortices of the cat. | D A Sholl | J Anat | 1953 | 13117757 | Yes |
| 1270 | 1736 | 1736.0 | 56.62 | 56.6 | Hypoxia-inducible factors in physiology and medicine. | Gregg L Semenza | Cell | 2012 | 22304911 | No |
| 1271 | 3470 | 1735.0 | 88.49 | 44.2 | The biology of vascular endothelial growth factor. | N Ferrara, T Davis-Smyth | Endocr Rev | 1997 | 9034784 | No |
| 1272 | 1733 | 1733.0 | 39.03 | 39.0 | The synaptic vesicle cycle: a cascade of protein-protein interactions. | T C Südhof | Nature | 1995 | 7791897 | No |
| 1273 | 1732 | 1732.0 | 61.72 | 61.7 | Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. | Sergio Pecorelli | Int J Gynaecol Obstet | 2009 | 19367689 | No |
| 1274 | 1731 | 1731.0 | 0.0 | 0.0 | ATPase activity of myosin correlated with speed of muscle shortening. | M Bárány | J Gen Physiol | 1967 | 4227924 | Yes |
| 1275 | 1731 | 1731.0 | 42.93 | 42.9 | Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. | D Lavanchy | J Viral Hepat | 2004 | 14996343 | No |
| 1276 | 3459 | 1729.5 | 93.83 | 46.9 | Prediction of protein antigenic determinants from amino acid sequences. | T P Hopp, K R Woods | Proc Natl Acad Sci U S A | 1981 | 6167991 | Yes |
| 1277 | 1729 | 1729.0 | 0.0 | 0.0 | Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. | J N Dumont | J Morphol | 1972 | 4109871 | Yes |
| 1278 | 1729 | 1729.0 | 36.56 | 36.6 | Structure and regulation of voltage-gated Ca2+ channels. | W A Catterall | Annu Rev Cell Dev Biol | 2000 | 11031246 | No |
| 1279 | 1729 | 1729.0 | 46.01 | 46.0 | What is cognitive reserve? Theory and research application of the reserve concept. | Yaakov Stern | J Int Neuropsychol Soc | 2002 | 11939702 | No |
| 1280 | 5183 | 1727.7 | 113.56 | 37.9 | Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. | A Nicholls, K A Sharp, B Honig | Proteins | 1991 | 1758883 | Yes |
| 1281 | 1727 | 1727.0 | 90.64 | 90.6 | Conservation of resources. A new attempt at conceptualizing stress. | S E Hobfoll | Am Psychol | 1989 | 2648906 | No |
| 1282 | 3454 | 1727.0 | 73.58 | 36.8 | Identification of common molecular subsequences. | T F Smith, M S Waterman | J Mol Biol | 1981 | 7265238 | Yes |
| 1283 | 1726 | 1726.0 | 62.28 | 62.3 | Cyclosporine. | B D Kahan | N Engl J Med | 1989 | 2687689 | No |
| 1284 | 1726 | 1726.0 | 55.15 | 55.1 | Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. | M Zasloff | Proc Natl Acad Sci U S A | 1987 | 3299384 | Yes |
| 1285 | 1726 | 1726.0 | 56.71 | 56.7 | Global epidemiology of oral and oropharyngeal cancer. | Saman Warnakulasuriya | Oral Oncol | 2009 | 18804401 | No |
| 1286 | 5177 | 1725.7 | 101.35 | 33.8 | Surfing the p53 network. | B Vogelstein, D Lane, A J Levine | Nature | 2000 | 11099028 | No |
| 1287 | 5174 | 1724.7 | 117.97 | 39.3 | Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. | Michael W Pfaffl, Graham W Horgan, Leo Dempfle | Nucleic Acids Res | 2002 | 11972351 | Yes |
| 1288 | 3445 | 1722.5 | 94.08 | 47.0 | Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. | K B Mullis, F A Faloona | Methods Enzymol | 1987 | 3431465 | Yes |
| 1289 | 1722 | 1722.0 | 83.93 | 83.9 | Statistics corner: A guide to appropriate use of correlation coefficient in medical research. | M M Mukaka | Malawi Med J | 2012 | 23638278 | Yes |
| 1290 | 3443 | 1721.5 | 83.09 | 41.5 | Liver fibrosis. | Ramón Bataller, David A Brenner | J Clin Invest | 2005 | 15690074 | No |
| 1291 | 1721 | 1721.0 | 0.0 | 0.0 | Dynamic properties of mammalian skeletal muscles. | R I Close | Physiol Rev | 1972 | 4256989 | No |
| 1292 | 1720 | 1720.0 | 36.48 | 36.5 | Molecular regulation of vessel maturation. | Rakesh K Jain | Nat Med | 2003 | 12778167 | No |
| 1293 | 1719 | 1719.0 | 32.24 | 32.2 | CD4+ CD25+ suppressor T cells: more questions than answers. | Ethan M Shevach | Nat Rev Immunol | 2002 | 12093005 | No |
| 1294 | 1719 | 1719.0 | 35.06 | 35.1 | Cancer and the chemokine network. | Fran Balkwill | Nat Rev Cancer | 2004 | 15229479 | No |
| 1295 | 5154 | 1718.0 | 232.58 | 77.5 | Some statistical methods useful in circulation research. | S Wallenstein, C L Zucker, J L Fleiss | Circ Res | 1980 | 7379260 | Yes |
| 1296 | 6868 | 1717.0 | 134.65 | 33.7 | Transformation of intact yeast cells treated with alkali cations. | H Ito, Y Fukuda, K Murata, A Kimura | J Bacteriol | 1983 | 6336730 | Yes |
| 1297 | 1716 | 1716.0 | 56.97 | 57.0 | Pineal melatonin: cell biology of its synthesis and of its physiological interactions. | R J Reiter | Endocr Rev | 1991 | 1649044 | No |
| 1298 | 3430 | 1715.0 | 91.15 | 45.6 | Cloned glutamate receptors. | M Hollmann, S Heinemann | Annu Rev Neurosci | 1994 | 8210177 | No |
| 1299 | 1715 | 1715.0 | 37.84 | 37.8 | Exploring complex networks. | S H Strogatz | Nature | 2001 | 11258382 | No |
| 1300 | 1715 | 1715.0 | 40.2 | 40.2 | Fabrication of novel biomaterials through molecular self-assembly. | Shuguang Zhang | Nat Biotechnol | 2003 | 14520402 | No |
| 1301 | 1714 | 1714.0 | 0.0 | 0.0 | The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. | R Ross | J Cell Biol | 1971 | 4327464 | Yes |
| 1302 | 1713 | 1713.0 | 58.26 | 58.3 | Large-scale neurocognitive networks and distributed processing for attention, language, and memory. | M M Mesulam | Ann Neurol | 1990 | 2260847 | No |
| 1303 | 1713 | 1713.0 | 0.0 | 0.0 | Evolutionary rate at the molecular level. | M Kimura | Nature | 1968 | 5637732 | Yes |
| 1304 | 1712 | 1712.0 | 68.93 | 68.9 | Predicting basal metabolic rate, new standards and review of previous work. | W N Schofield | Hum Nutr Clin Nutr | 1985 | 4044297 | Yes |
| 1305 | 3421 | 1710.5 | 0.0 | 0.0 | Receptive fields and functional architecture of monkey striate cortex. | D H Hubel, T N Wiesel | J Physiol | 1968 | 4966457 | Yes |
| 1306 | 1710 | 1710.0 | 0.0 | 0.0 | Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. | E M Witkin | Bacteriol Rev | 1976 | 795416 | No |
| 1307 | 1710 | 1710.0 | 43.02 | 43.0 | Episodic memory: from mind to brain. | Endel Tulving | Annu Rev Psychol | 2002 | 11752477 | Yes |
| 1308 | 1710 | 1710.0 | 50.29 | 50.3 | Introduction and General Overview of Cyclodextrin Chemistry. | József Szejtli | Chem Rev | 1998 | 11848947 | Yes |
| 1309 | 1709 | 1709.0 | 41.27 | 41.3 | Type III protein secretion systems in bacterial pathogens of animals and plants. | C J Hueck | Microbiol Mol Biol Rev | 1998 | 9618447 | No |
| 1310 | 3417 | 1708.5 | 0.0 | 0.0 | The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. | A E Bolton, W M Hunter | Biochem J | 1973 | 4733239 | Yes |
| 1311 | 1708 | 1708.0 | 54.42 | 54.4 | Glutamate: a neurotransmitter in mammalian brain. | F Fonnum | J Neurochem | 1984 | 6139418 | No |
| 1312 | 3416 | 1708.0 | 86.16 | 43.1 | Matrix metalloproteinases. | H Nagase, J F Woessner | J Biol Chem | 1999 | 10419448 | No |
| 1313 | 1706 | 1706.0 | 0.0 | 0.0 | Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. | M Wong-Riley | Brain Res | 1979 | 223730 | Yes |
| 1314 | 8529 | 1705.8 | 233.41 | 46.7 | Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. | Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary King | Diabetes Care | 2004 | 15111519 | Yes |
| 1315 | 1705 | 1705.0 | 41.63 | 41.6 | Evolutionary relationship of DNA sequences in finite populations. | F Tajima | Genetics | 1983 | 6628982 | Yes |
| 1316 | 11923 | 1703.3 | 436.69 | 62.4 | Assessing the quality of reports of randomized clinical trials: is blinding necessary? | A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuay | Control Clin Trials | 1996 | 8721797 | Yes |
| 1317 | 1703 | 1703.0 | 0.0 | 0.0 | Why genes in pieces? | W Gilbert | Nature | 1978 | 622185 | Yes |
| 1318 | 1703 | 1703.0 | 57.02 | 57.0 | The crisis in antibiotic resistance. | H C Neu | Science | 1992 | 1509257 | No |
| 1319 | 17012 | 1701.2 | 540.66 | 54.1 | Measurement of protein using bicinchoninic acid. | P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C Klenk | Anal Biochem | 1985 | 3843705 | Yes |
| 1320 | 1701 | 1701.0 | 57.4 | 57.4 | Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. | C E Mogensen | N Engl J Med | 1984 | 6690964 | Yes |
| 1321 | 15309 | 1701.0 | 546.94 | 60.8 | STAR: ultrafast universal RNA-seq aligner. | Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R Gingeras | Bioinformatics | 2013 | 23104886 | Yes |
| 1322 | 1700 | 1700.0 | 0.0 | 0.0 | Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. | A F Habeeb | Anal Biochem | 1966 | 4161471 | Yes |
| 1323 | 1700 | 1700.0 | 45.49 | 45.5 | P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation. | Berk Hess | J Chem Theory Comput | 2008 | 26619985 | Yes |
| 1324 | 1699 | 1699.0 | 0.0 | 0.0 | A graphic method for the determination and presentation of binding parameters in a complex system. | H E Rosenthal | Anal Biochem | 1967 | 6048188 | Yes |
| 1325 | 1698 | 1698.0 | 0.0 | 0.0 | The general adaptation syndrome and the diseases of adaptation. | H Selye | J Clin Endocrinol Metab | 1946 | 21025115 | Yes |
| 1326 | 1697 | 1697.0 | 32.0 | 32.0 | How eukaryotic transcriptional activators work. | M Ptashne | Nature | 1988 | 3050531 | No |
| 1327 | 1697 | 1697.0 | 44.8 | 44.8 | Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. | G C Walker | Microbiol Rev | 1984 | 6371470 | No |
| 1328 | 1697 | 1697.0 | 45.23 | 45.2 | Dengue and dengue hemorrhagic fever. | D J Gubler | Clin Microbiol Rev | 1998 | 9665979 | No |
| 1329 | 1697 | 1697.0 | 47.25 | 47.2 | Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. | Robert E Marx | J Oral Maxillofac Surg | 2003 | 12966493 | Yes |
| 1330 | 3394 | 1697.0 | 82.2 | 41.1 | PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. | Alexander W Schüttelkopf, Daan M F van Aalten | Acta Crystallogr D Biol Crystallogr | 2004 | 15272157 | Yes |
| 1331 | 1696 | 1696.0 | 0.0 | 0.0 | Areas, volumes, packing and protein structure. | F M Richards | Annu Rev Biophys Bioeng | 1977 | 326146 | No |
| 1332 | 1696 | 1696.0 | 45.92 | 45.9 | Integrins. | E Ruoslahti | J Clin Invest | 1991 | 1985087 | No |
| 1333 | 6784 | 1696.0 | 180.17 | 45.0 | Epithelial-mesenchymal transitions in development and disease. | Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela Nieto | Cell | 2009 | 19945376 | No |
| 1334 | 3391 | 1695.5 | 75.33 | 37.7 | Monocyte and macrophage heterogeneity. | Siamon Gordon, Philip R Taylor | Nat Rev Immunol | 2005 | 16322748 | No |
| 1335 | 1695 | 1695.0 | 0.0 | 0.0 | The statistical analysis of enzyme kinetic data. | W W Cleland | Adv Enzymol Relat Areas Mol Biol | 1967 | 4881884 | No |
| 1336 | 3390 | 1695.0 | 0.0 | 0.0 | A "Direct-Coloring" Thiocholine Method For Cholinesterases. | M J Karnovsky, L Roots | J Histochem Cytochem | 1964 | 14187330 | Yes |
| 1337 | 1694 | 1694.0 | 0.0 | 0.0 | Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. | A Krishan | J Cell Biol | 1975 | 49354 | Yes |
| 1338 | 1693 | 1693.0 | 53.35 | 53.4 | The atom economy--a search for synthetic efficiency. | B M Trost | Science | 1991 | 1962206 | Yes |
| 1339 | 1692 | 1692.0 | 48.23 | 48.2 | Cell biology and molecular basis of denitrification. | W G Zumft | Microbiol Mol Biol Rev | 1997 | 9409151 | No |
| 1340 | 1687 | 1687.0 | 40.79 | 40.8 | The molecular genetics of cancer. | J M Bishop | Science | 1987 | 3541204 | No |
| 1341 | 1687 | 1687.0 | 35.43 | 35.4 | The effect of infections on susceptibility to autoimmune and allergic diseases. | Jean-Francois Bach | N Engl J Med | 2002 | 12239261 | No |
| 1342 | 1687 | 1687.0 | 0.0 | 0.0 | Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. | J Spizizen | Proc Natl Acad Sci U S A | 1958 | 16590310 | Yes |
| 1343 | 3372 | 1686.0 | 77.82 | 38.9 | Amino acid substitution matrices from protein blocks. | S Henikoff, J G Henikoff | Proc Natl Acad Sci U S A | 1992 | 1438297 | Yes |
| 1344 | 1686 | 1686.0 | 46.78 | 46.8 | Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. | H LeVine | Protein Sci | 1993 | 8453378 | Yes |
| 1345 | 3372 | 1686.0 | 99.03 | 49.5 | The unfolded protein response: from stress pathway to homeostatic regulation. | Peter Walter, David Ron | Science | 2011 | 22116877 | No |
| 1346 | 1685 | 1685.0 | 46.53 | 46.5 | The comet assay for DNA damage and repair: principles, applications, and limitations. | Andrew R Collins | Mol Biotechnol | 2004 | 15004294 | No |
| 1347 | 1684 | 1684.0 | 39.87 | 39.9 | Solvent-accessible surfaces of proteins and nucleic acids. | M L Connolly | Science | 1983 | 6879170 | Yes |
| 1348 | 3368 | 1684.0 | 78.18 | 39.1 | Parkinson's disease: mechanisms and models. | William Dauer, Serge Przedborski | Neuron | 2003 | 12971891 | No |
| 1349 | 1683 | 1683.0 | 56.93 | 56.9 | Serum albumin. | T Peters | Adv Protein Chem | 1985 | 3904348 | No |
| 1350 | 1683 | 1683.0 | 0.0 | 0.0 | The theory and applications of the exchange of inert gas at the lungs and tissues. | S S Kety | Pharmacol Rev | 1951 | 14833874 | Yes |
| 1351 | 3366 | 1683.0 | 94.35 | 47.2 | Building better batteries. | M Armand, J-M Tarascon | Nature | 2008 | 18256660 | No |
| 1352 | 3365 | 1682.5 | 72.49 | 36.2 | Integrin signaling. | F G Giancotti, E Ruoslahti | Science | 1999 | 10446041 | No |
| 1353 | 1682 | 1682.0 | 0.0 | 0.0 | Mode of cell migration to the superficial layers of fetal monkey neocortex. | P Rakic | J Comp Neurol | 1972 | 4624784 | Yes |
| 1354 | 1682 | 1682.0 | 57.37 | 57.4 | Grounded cognition. | Lawrence W Barsalou | Annu Rev Psychol | 2008 | 17705682 | No |
| 1355 | 1681 | 1681.0 | 44.21 | 44.2 | The genetics of ageing. | Cynthia J Kenyon | Nature | 2010 | 20336132 | No |
| 1356 | 6723 | 1680.8 | 0.0 | 0.0 | Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. | E A Jaffe, R L Nachman, C G Becker, C R Minick | J Clin Invest | 1973 | 4355998 | Yes |
| 1357 | 1680 | 1680.0 | 58.82 | 58.8 | Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? | B Halliwell | Lancet | 1994 | 7915779 | No |
| 1358 | 3358 | 1679.0 | 94.06 | 47.0 | Biochemistry of multidrug resistance mediated by the multidrug transporter. | M M Gottesman, I Pastan | Annu Rev Biochem | 1993 | 8102521 | No |
| 1359 | 1679 | 1679.0 | 0.0 | 0.0 | Plastic Embedding Mixtures For Use In Electron Microscopy. | H H Mollenhauer | Stain Technol | 1964 | 14127791 | Yes |
| 1360 | 1678 | 1678.0 | 61.06 | 61.1 | Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). | G G Glenner | N Engl J Med | 1980 | 6154243 | No |
| 1361 | 3355 | 1677.5 | 66.95 | 33.5 | SIFT: Predicting amino acid changes that affect protein function. | Pauline C Ng, Steven Henikoff | Nucleic Acids Res | 2003 | 12824425 | Yes |
| 1362 | 6699 | 1674.8 | 176.76 | 44.2 | Cancer-related inflammation. | Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill | Nature | 2008 | 18650914 | No |
| 1363 | 3345 | 1672.5 | 0.0 | 0.0 | New method for quantitative determination of uronic acids. | N Blumenkrantz, G Asboe-Hansen | Anal Biochem | 1973 | 4269305 | Yes |
| 1364 | 1672 | 1672.0 | 0.0 | 0.0 | Chromatographic Separation Of Human Brain Gangliosides. | L Svennerholm | J Neurochem | 1963 | 14066623 | Yes |
| 1365 | 8357 | 1671.4 | 213.68 | 42.7 | Mapping and quantifying mammalian transcriptomes by RNA-Seq. | Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara Wold | Nat Methods | 2008 | 18516045 | Yes |
| 1366 | 1671 | 1671.0 | 0.0 | 0.0 | Drugs which inhibit prostaglandin biosynthesis. | R J Flower | Pharmacol Rev | 1974 | 4208101 | Yes |
| 1367 | 1671 | 1671.0 | 56.01 | 56.0 | Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. | Leonardo Pantoni | Lancet Neurol | 2010 | 20610345 | No |
| 1368 | 6683 | 1670.8 | 135.84 | 34.0 | Stem cells, cancer, and cancer stem cells. | T Reya, S J Morrison, M F Clarke, I L Weissman | Nature | 2001 | 11689955 | No |
| 1369 | 3341 | 1670.5 | 123.83 | 61.9 | Shifting the genomic gold standard for the prokaryotic species definition. | Michael Richter, Ramon Rosselló-Móra | Proc Natl Acad Sci U S A | 2009 | 19855009 | Yes |
| 1370 | 1670 | 1670.0 | 58.35 | 58.4 | Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. | A H Conney | Cancer Res | 1982 | 6814745 | No |
| 1371 | 1669 | 1669.0 | 32.13 | 32.1 | Cellular roles of DNA topoisomerases: a molecular perspective. | James C Wang | Nat Rev Mol Cell Biol | 2002 | 12042765 | No |
| 1372 | 1669 | 1669.0 | 0.0 | 0.0 | Method for the determination of hexosamines in tissues. | N F Boas | J Biol Chem | 1953 | 13117829 | Yes |
| 1373 | 1668 | 1668.0 | 0.0 | 0.0 | An improved procedure for serum creatine phosphokinase determination. | S B Rosalki | J Lab Clin Med | 1967 | 4381359 | Yes |
| 1374 | 1668 | 1668.0 | 0.0 | 0.0 | Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. | J A Miller | Cancer Res | 1970 | 4915745 | No |
| 1375 | 1668 | 1668.0 | 0.0 | 0.0 | Carbonic anhydrase: chemistry, physiology, and inhibition. | T H Maren | Physiol Rev | 1967 | 4964060 | No |
| 1376 | 3336 | 1668.0 | 0.0 | 0.0 | Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. | J Marmur, P Doty | J Mol Biol | 1962 | 14470099 | Yes |
| 1377 | 1667 | 1667.0 | 52.96 | 53.0 | Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? | George A Bonanno | Am Psychol | 2004 | 14736317 | No |
| 1378 | 3333 | 1666.5 | 85.89 | 42.9 | Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. | Christian Haass, Dennis J Selkoe | Nat Rev Mol Cell Biol | 2007 | 17245412 | No |
| 1379 | 1666 | 1666.0 | 38.87 | 38.9 | The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. | D M Kingsley | Genes Dev | 1994 | 8299934 | No |
| 1380 | 1665 | 1665.0 | 49.2 | 49.2 | Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. | E M Wassermann | Electroencephalogr Clin Neurophysiol | 1998 | 9474057 | No |
| 1381 | 11645 | 1663.6 | 534.66 | 76.4 | limma powers differential expression analyses for RNA-sequencing and microarray studies. | Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth | Nucleic Acids Res | 2015 | 25605792 | Yes |
| 1382 | 3327 | 1663.5 | 0.0 | 0.0 | Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. | M Grunstein, D S Hogness | Proc Natl Acad Sci U S A | 1975 | 1105573 | Yes |
| 1383 | 1662 | 1662.0 | 37.83 | 37.8 | Effects of cytochalasin and phalloidin on actin. | J A Cooper | J Cell Biol | 1987 | 3312229 | No |
| 1384 | 1662 | 1662.0 | 41.53 | 41.5 | Clinical application of C-reactive protein for cardiovascular disease detection and prevention. | Paul M Ridker | Circulation | 2003 | 12551853 | No |
| 1385 | 3319 | 1659.5 | 94.14 | 47.1 | Biofilms: survival mechanisms of clinically relevant microorganisms. | Rodney M Donlan, J William Costerton | Clin Microbiol Rev | 2002 | 11932229 | No |
| 1386 | 1659 | 1659.0 | 45.27 | 45.3 | Chlorpromazine equivalent doses for the newer atypical antipsychotics. | Scott W Woods | J Clin Psychiatry | 2003 | 12823080 | No |
| 1387 | 3315 | 1657.5 | 114.34 | 57.2 | Macrophage plasticity and polarization: in vivo veritas. | Antonio Sica, Alberto Mantovani | J Clin Invest | 2012 | 22378047 | No |
| 1388 | 3313 | 1656.5 | 0.0 | 0.0 | Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. | M Mihara, M Uchiyama | Anal Biochem | 1978 | 655387 | Yes |
| 1389 | 1656 | 1656.0 | 0.0 | 0.0 | The micronucleus test. | W Schmid | Mutat Res | 1975 | 48190 | Yes |
| 1390 | 1656 | 1656.0 | 45.68 | 45.7 | Oxidative stress hypothesis in Alzheimer's disease. | W R Markesbery | Free Radic Biol Med | 1997 | 9165306 | No |
| 1391 | 3311 | 1655.5 | 144.79 | 72.4 | A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. | J G Snodgrass, M Vanderwart | J Exp Psychol Hum Learn | 1980 | 7373248 | Yes |
| 1392 | 4966 | 1655.3 | 158.06 | 52.7 | Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. | H Esterbauer, R J Schaur, H Zollner | Free Radic Biol Med | 1991 | 1937131 | No |
| 1393 | 3310 | 1655.0 | 109.72 | 54.9 | Role of free radicals and catalytic metal ions in human disease: an overview. | B Halliwell, J M Gutteridge | Methods Enzymol | 1990 | 2172697 | No |
| 1394 | 1655 | 1655.0 | 0.0 | 0.0 | Pedigrees of some mutant strains of Escherichia coli K-12. | B J Bachmann | Bacteriol Rev | 1972 | 4568763 | No |
| 1395 | 3308 | 1654.0 | 0.0 | 0.0 | Variations in the pattern of pubertal changes in boys. | W A Marshall, J M Tanner | Arch Dis Child | 1970 | 5440182 | Yes |
| 1396 | 3306 | 1653.0 | 100.02 | 50.0 | Autophagy: renovation of cells and tissues. | Noboru Mizushima, Masaaki Komatsu | Cell | 2011 | 22078875 | No |
| 1397 | 6610 | 1652.5 | 153.55 | 38.4 | Use of T7 RNA polymerase to direct expression of cloned genes. | F W Studier, A H Rosenberg, J J Dunn, J W Dubendorff | Methods Enzymol | 1990 | 2199796 | Yes |
| 1398 | 16525 | 1652.5 | 530.06 | 53.0 | The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. | F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S Luthra | Arthritis Rheum | 1988 | 3358796 | Yes |
| 1399 | 3304 | 1652.0 | 103.03 | 51.5 | Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. | F Denizot, R Lang | J Immunol Methods | 1986 | 3486233 | Yes |
| 1400 | 3303 | 1651.5 | 84.63 | 42.3 | Receptors for purines and pyrimidines. | V Ralevic, G Burnstock | Pharmacol Rev | 1998 | 9755289 | No |
| 1401 | 1650 | 1650.0 | 0.0 | 0.0 | Chromatin structure: a repeating unit of histones and DNA. | R D Kornberg | Science | 1974 | 4825889 | Yes |
| 1402 | 3300 | 1650.0 | 137.53 | 68.8 | miRBase: annotating high confidence microRNAs using deep sequencing data. | Ana Kozomara, Sam Griffiths-Jones | Nucleic Acids Res | 2014 | 24275495 | Yes |
| 1403 | 3298 | 1649.0 | 85.95 | 43.0 | Quantum dot bioconjugates for ultrasensitive nonisotopic detection. | W C Chan, S Nie | Science | 1998 | 9748158 | Yes |
| 1404 | 1649 | 1649.0 | 36.26 | 36.3 | Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. | S L Friedman | J Biol Chem | 2000 | 10644669 | No |
| 1405 | 3297 | 1648.5 | 0.0 | 0.0 | The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. | T Omura, R Sato | J Biol Chem | 1964 | 14209972 | Yes |
| 1406 | 3291 | 1645.5 | 88.53 | 44.3 | Protein structure prediction on the Web: a case study using the Phyre server. | Lawrence A Kelley, Michael J E Sternberg | Nat Protoc | 2009 | 19247286 | Yes |
| 1407 | 3290 | 1645.0 | 129.75 | 64.9 | Assays of glutathione peroxidase. | L Flohé, W A Günzler | Methods Enzymol | 1984 | 6727659 | Yes |
| 1408 | 1645 | 1645.0 | 0.0 | 0.0 | A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. | D Mattingly | J Clin Pathol | 1962 | 14471419 | Yes |
| 1409 | 1645 | 1645.0 | 62.78 | 62.8 | Large-scale brain networks and psychopathology: a unifying triple network model. | Vinod Menon | Trends Cogn Sci | 2011 | 21908230 | No |
| 1410 | 3286 | 1643.0 | 0.0 | 0.0 | Method for the isolation of intact islets of Langerhans from the rat pancreas. | P E Lacy, M Kostianovsky | Diabetes | 1967 | 5333500 | Yes |
| 1411 | 1642 | 1642.0 | 38.73 | 38.7 | Recognition of microorganisms and activation of the immune response. | Ruslan Medzhitov | Nature | 2007 | 17943118 | No |
| 1412 | 3283 | 1641.5 | 89.01 | 44.5 | Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. | Steven E Nissen, Kathy Wolski | N Engl J Med | 2007 | 17517853 | Yes |
| 1413 | 1640 | 1640.0 | 52.53 | 52.5 | Metallothionein. | D H Hamer | Annu Rev Biochem | 1986 | 3527054 | No |
| 1414 | 1640 | 1640.0 | 45.77 | 45.8 | Turnover of inositol phospholipids and signal transduction. | Y Nishizuka | Science | 1984 | 6147898 | No |
| 1415 | 1640 | 1640.0 | 38.56 | 38.6 | NADPH oxidase: an update. | B M Babior | Blood | 1999 | 10029572 | No |
| 1416 | 3280 | 1640.0 | 80.28 | 40.1 | Neuronal oscillations in cortical networks. | György Buzsáki, Andreas Draguhn | Science | 2004 | 15218136 | No |
| 1417 | 1638 | 1638.0 | 68.08 | 68.1 | Negative symptoms in schizophrenia. Definition and reliability. | N C Andreasen | Arch Gen Psychiatry | 1982 | 7165477 | Yes |
| 1418 | 3274 | 1637.0 | 0.0 | 0.0 | A fluorometric method for determination of oxidized and reduced glutathione in tissues. | P J Hissin, R Hilf | Anal Biochem | 1976 | 962076 | Yes |
| 1419 | 1637 | 1637.0 | 32.42 | 32.4 | Hox genes in vertebrate development. | R Krumlauf | Cell | 1994 | 7913880 | No |
| 1420 | 9817 | 1636.2 | 281.23 | 46.9 | Positional cloning of the mouse obese gene and its human homologue. | Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M Friedman | Nature | 1994 | 7984236 | Yes |
| 1421 | 3272 | 1636.0 | 78.77 | 39.4 | The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. | P Angel, M Karin | Biochim Biophys Acta | 1991 | 1751545 | No |
| 1422 | 1636 | 1636.0 | 0.0 | 0.0 | RNA-dependent DNA polymerase in virions of RNA tumour viruses. | D Baltimore | Nature | 1970 | 4316300 | Yes |
| 1423 | 1636 | 1636.0 | 40.01 | 40.0 | Inflammatory bowel disease: etiology and pathogenesis. | C Fiocchi | Gastroenterology | 1998 | 9649475 | No |
| 1424 | 1636 | 1636.0 | 35.41 | 35.4 | Excitatory actions of gaba during development: the nature of the nurture. | Yehezkel Ben-Ari | Nat Rev Neurosci | 2002 | 12209121 | No |
| 1425 | 1636 | 1636.0 | 47.49 | 47.5 | Trail Making Test A and B: normative data stratified by age and education. | Tom N Tombaugh | Arch Clin Neuropsychol | 2004 | 15010086 | Yes |
| 1426 | 3272 | 1636.0 | 90.43 | 45.2 | The mirror-neuron system. | Giacomo Rizzolatti, Laila Craighero | Annu Rev Neurosci | 2004 | 15217330 | No |
| 1427 | 3272 | 1636.0 | 108.03 | 54.0 | Understanding interobserver agreement: the kappa statistic. | Anthony J Viera, Joanne M Garrett | Fam Med | 2005 | 15883903 | Yes |
| 1428 | 1635 | 1635.0 | 32.39 | 32.4 | Cell cycle checkpoints: preventing an identity crisis. | S J Elledge | Science | 1996 | 8939848 | No |
| 1429 | 11444 | 1634.9 | 290.53 | 41.5 | Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. | William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan | N Engl J Med | 2002 | 11832527 | Yes |
| 1430 | 4901 | 1633.7 | 150.63 | 50.2 | Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. | P A Wolf, R D Abbott, W B Kannel | Stroke | 1991 | 1866765 | Yes |
| 1431 | 1632 | 1632.0 | 46.21 | 46.2 | Determination of minimum inhibitory concentrations. | J M Andrews | J Antimicrob Chemother | 2001 | 11420333 | Yes |
| 1432 | 3264 | 1632.0 | 75.8 | 37.9 | Issues and challenges facing rechargeable lithium batteries. | J M Tarascon, M Armand | Nature | 2001 | 11713543 | Yes |
| 1433 | 1631 | 1631.0 | 39.41 | 39.4 | The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. | Michael R Lieber | Annu Rev Biochem | 2010 | 20192759 | No |
| 1434 | 6524 | 1631.0 | 300.96 | 75.2 | jModelTest 2: more models, new heuristics and parallel computing. | Diego Darriba, Guillermo L Taboada, Ramón Doallo, David Posada | Nat Methods | 2012 | 22847109 | Yes |
| 1435 | 1631 | 1631.0 | 71.75 | 71.8 | Gctf: Real-time CTF determination and correction. | Kai Zhang | J Struct Biol | 2016 | 26592709 | Yes |
| 1436 | 1628 | 1628.0 | 34.21 | 34.2 | Points of control in inflammation. | Carl Nathan | Nature | 2002 | 12490957 | No |
| 1437 | 1627 | 1627.0 | 33.76 | 33.8 | Structural features in eukaryotic mRNAs that modulate the initiation of translation. | M Kozak | J Biol Chem | 1991 | 1939050 | No |
| 1438 | 3253 | 1626.5 | 71.37 | 35.7 | Protein structure comparison by alignment of distance matrices. | L Holm, C Sander | J Mol Biol | 1993 | 8377180 | Yes |
| 1439 | 1626 | 1626.0 | 49.18 | 49.2 | Extracellular ATP: effects, sources and fate. | J L Gordon | Biochem J | 1986 | 3006665 | No |
| 1440 | 1626 | 1626.0 | 45.74 | 45.7 | Leptospirosis. | P N Levett | Clin Microbiol Rev | 2001 | 11292640 | No |
| 1441 | 1626 | 1626.0 | 35.04 | 35.0 | Protein homology detection by HMM-HMM comparison. | Johannes Söding | Bioinformatics | 2005 | 15531603 | Yes |
| 1442 | 1625 | 1625.0 | 58.72 | 58.7 | Cell damage in the brain: a speculative synthesis. | B K Siesjö | J Cereb Blood Flow Metab | 1981 | 6276420 | No |
| 1443 | 1625 | 1625.0 | 69.79 | 69.8 | The drug abuse screening test. | H A Skinner | Addict Behav | 1982 | 7183189 | Yes |
| 1444 | 1625 | 1625.0 | 41.84 | 41.8 | Neurotrophins and neuronal plasticity. | H Thoenen | Science | 1995 | 7570017 | No |
| 1445 | 1625 | 1625.0 | 48.29 | 48.3 | Multiple imputation: a primer. | J L Schafer | Stat Methods Med Res | 1999 | 10347857 | No |
| 1446 | 1625 | 1625.0 | 38.09 | 38.1 | Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. | S A Bustin | J Mol Endocrinol | 2002 | 12200227 | No |
| 1447 | 1624 | 1624.0 | 70.66 | 70.7 | KDIGO clinical practice guidelines for acute kidney injury. | Arif Khwaja | Nephron Clin Pract | 2012 | 22890468 | No |
| 1448 | 3246 | 1623.0 | 119.09 | 59.5 | ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. | M Gardes, T D Bruns | Mol Ecol | 1993 | 8180733 | Yes |
| 1449 | 3246 | 1623.0 | 94.21 | 47.1 | Event-related EEG/MEG synchronization and desynchronization: basic principles. | G Pfurtscheller, F H Lopes da Silva | Clin Neurophysiol | 1999 | 10576479 | No |
| 1450 | 8115 | 1623.0 | 200.61 | 40.1 | Development and testing of a general amber force field. | Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A Case | J Comput Chem | 2004 | 15116359 | Yes |
| 1451 | 1622 | 1622.0 | 53.55 | 53.5 | A new automated colorimetric method for measuring total oxidant status. | Ozcan Erel | Clin Biochem | 2005 | 16214125 | Yes |
| 1452 | 4865 | 1621.7 | 114.72 | 38.2 | Inflammation and atherosclerosis. | Peter Libby, Paul M Ridker, Attilio Maseri | Circulation | 2002 | 11877368 | No |
| 1453 | 1621 | 1621.0 | 30.37 | 30.4 | Cyclin-dependent kinases: engines, clocks, and microprocessors. | D O Morgan | Annu Rev Cell Dev Biol | 1997 | 9442875 | No |
| 1454 | 3242 | 1621.0 | 71.13 | 35.6 | Insulin signalling and the regulation of glucose and lipid metabolism. | A R Saltiel, C R Kahn | Nature | 2001 | 11742412 | Yes |
| 1455 | 1620 | 1620.0 | 40.11 | 40.1 | Python: a programming language for software integration and development. | M F Sanner | J Mol Graph Model | 1999 | 10660911 | Yes |
| 1456 | 1620 | 1620.0 | 45.27 | 45.3 | Oxidative stress and neurodegeneration: where are we now? | Barry Halliwell | J Neurochem | 2006 | 16805774 | No |
| 1457 | 1619 | 1619.0 | 70.96 | 71.0 | Neurogenetic adaptive mechanisms in alcoholism. | C R Cloninger | Science | 1987 | 2882604 | Yes |
| 1458 | 1619 | 1619.0 | 47.27 | 47.3 | Perceptual symbol systems. | L W Barsalou | Behav Brain Sci | 1999 | 11301525 | No |
| 1459 | 1616 | 1616.0 | 50.48 | 50.5 | A measure of population subdivision based on microsatellite allele frequencies. | M Slatkin | Genetics | 1995 | 7705646 | Yes |
| 1460 | 6460 | 1615.0 | 317.15 | 79.3 | The Satisfaction With Life Scale. | E Diener, R A Emmons, R J Larsen, S Griffin | J Pers Assess | 1985 | 16367493 | Yes |
| 1461 | 1614 | 1614.0 | 40.44 | 40.4 | Angiogenesis: an organizing principle for drug discovery? | Judah Folkman | Nat Rev Drug Discov | 2007 | 17396134 | No |
| 1462 | 1614 | 1614.0 | 39.86 | 39.9 | Tumor angiogenesis. | Robert S Kerbel | N Engl J Med | 2008 | 18463380 | No |
| 1463 | 3227 | 1613.5 | 79.07 | 39.5 | CAP3: A DNA sequence assembly program. | X Huang, A Madan | Genome Res | 1999 | 10508846 | Yes |
| 1464 | 1613 | 1613.0 | 62.64 | 62.6 | Simple proton spectroscopic imaging. | W T Dixon | Radiology | 1984 | 6089263 | Yes |
| 1465 | 1613 | 1613.0 | 37.11 | 37.1 | Cellular oncogenes and retroviruses. | J M Bishop | Annu Rev Biochem | 1983 | 6351725 | No |
| 1466 | 4839 | 1613.0 | 104.49 | 34.8 | A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. | Zhang, Chung, Oldenburg | J Biomol Screen | 1999 | 10838414 | Yes |
| 1467 | 1613 | 1613.0 | 33.04 | 33.0 | The synaptic vesicle cycle. | Thomas C Sudhof | Annu Rev Neurosci | 2004 | 15217342 | No |
| 1468 | 1613 | 1613.0 | 42.09 | 42.1 | Adipose tissue, adipokines, and inflammation. | Giamila Fantuzzi | J Allergy Clin Immunol | 2005 | 15867843 | No |
| 1469 | 4835 | 1611.7 | 134.18 | 44.7 | The metabolic syndrome--a new worldwide definition. | K George M M Alberti, Paul Zimmet, Jonathan Shaw | Lancet | 2005 | 16182882 | Yes |
| 1470 | 1611 | 1611.0 | 0.0 | 0.0 | Paced auditory serial-addition task: a measure of recovery from concussion. | D M Gronwall | Percept Mot Skills | 1977 | 866038 | Yes |
| 1471 | 1611 | 1611.0 | 50.83 | 50.8 | Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. | D W Choi | Trends Neurosci | 1988 | 2469166 | No |
| 1472 | 1611 | 1611.0 | 63.19 | 63.2 | Modeling and variable selection in epidemiologic analysis. | S Greenland | Am J Public Health | 1989 | 2916724 | Yes |
| 1473 | 1611 | 1611.0 | 0.0 | 0.0 | Computerized transverse axial scanning (tomography). 1. Description of system. | G N Hounsfield | Br J Radiol | 1973 | 4757352 | Yes |
| 1474 | 1611 | 1611.0 | 32.98 | 33.0 | Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. | Judith Campisi | Cell | 2005 | 15734683 | No |
| 1475 | 1610 | 1610.0 | 43.1 | 43.1 | From sensation to cognition. | M M Mesulam | Brain | 1998 | 9648540 | No |
| 1476 | 1609 | 1609.0 | 79.88 | 79.9 | The biology and function of fibroblasts in cancer. | Raghu Kalluri | Nat Rev Cancer | 2016 | 27550820 | No |
| 1477 | 1608 | 1608.0 | 0.0 | 0.0 | The relationship between the spleen colony-forming cell and the haemopoietic stem cell. | R Schofield | Blood Cells | 1978 | 747780 | Yes |
| 1478 | 1608 | 1608.0 | 47.27 | 47.3 | Metalloproteinases and their inhibitors in matrix remodeling. | L M Matrisian | Trends Genet | 1990 | 2132731 | No |
| 1479 | 3216 | 1608.0 | 77.63 | 38.8 | The DNA-damage response in human biology and disease. | Stephen P Jackson, Jiri Bartek | Nature | 2009 | 19847258 | No |
| 1480 | 3215 | 1607.5 | 77.55 | 38.8 | Rapid and sensitive protein similarity searches. | D J Lipman, W R Pearson | Science | 1985 | 2983426 | Yes |
| 1481 | 1607 | 1607.0 | 48.65 | 48.6 | Classification of inflammatory bowel disease. | J E Lennard-Jones | Scand J Gastroenterol Suppl | 1989 | 2617184 | Yes |
| 1482 | 1607 | 1607.0 | 35.05 | 35.0 | Bone morphogenetic proteins: multifunctional regulators of vertebrate development. | B L Hogan | Genes Dev | 1996 | 8682290 | No |
| 1483 | 1607 | 1607.0 | 29.61 | 29.6 | Maximum-likelihood density modification. | T C Terwilliger | Acta Crystallogr D Biol Crystallogr | 2000 | 10944333 | Yes |
| 1484 | 1605 | 1605.0 | 0.0 | 0.0 | Structural considerations in the interaction of DNA and acridines. | L S Lerman | J Mol Biol | 1961 | 13761054 | Yes |
| 1485 | 1605 | 1605.0 | 0.0 | 0.0 | Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. | E G Gray | J Anat | 1959 | 13829103 | Yes |
| 1486 | 1604 | 1604.0 | 32.01 | 32.0 | Generating samples under a Wright-Fisher neutral model of genetic variation. | Richard R Hudson | Bioinformatics | 2002 | 11847089 | Yes |
| 1487 | 1603 | 1603.0 | 54.07 | 54.1 | Number of people with glaucoma worldwide. | H A Quigley | Br J Ophthalmol | 1996 | 8695555 | No |
| 1488 | 1603 | 1603.0 | 45.92 | 45.9 | Molecular dissection of reactive astrogliosis and glial scar formation. | Michael V Sofroniew | Trends Neurosci | 2009 | 19782411 | No |
| 1489 | 12822 | 1602.8 | 333.15 | 41.6 | Electric field effect in atomically thin carbon films. | K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A Firsov | Science | 2004 | 15499015 | Yes |
| 1490 | 1602 | 1602.0 | 0.0 | 0.0 | Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. | K O Fagerström | Addict Behav | 1978 | 735910 | Yes |
| 1491 | 1602 | 1602.0 | 42.05 | 42.0 | Alpha-crystallin can function as a molecular chaperone. | J Horwitz | Proc Natl Acad Sci U S A | 1992 | 1438232 | Yes |
| 1492 | 1602 | 1602.0 | 36.95 | 37.0 | VLA proteins in the integrin family: structures, functions, and their role on leukocytes. | M E Hemler | Annu Rev Immunol | 1990 | 2188667 | No |
| 1493 | 4804 | 1601.3 | 105.93 | 35.3 | Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. | J E Darnell, I M Kerr, G R Stark | Science | 1994 | 8197455 | No |
| 1494 | 3202 | 1601.0 | 0.0 | 0.0 | Convergent and discriminant validation by the multitrait-multimethod matrix. | D T Campbell, D W Fiske | Psychol Bull | 1959 | 13634291 | Yes |
| 1495 | 1601 | 1601.0 | 49.25 | 49.2 | Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). | Gunther Eysenbach | J Med Internet Res | 2004 | 15471760 | No |
| 1496 | 1600 | 1600.0 | 0.0 | 0.0 | Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. | O Ouchterlony | Acta Pathol Microbiol Scand | 1953 | 13079779 | Yes |
| 1497 | 3199 | 1599.5 | 63.66 | 31.8 | Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. | M E Greenberg, E B Ziff | Nature | 1984 | 6090941 | Yes |
| 1498 | 1598 | 1598.0 | 38.88 | 38.9 | The retinal pigment epithelium in visual function. | Olaf Strauss | Physiol Rev | 2005 | 15987797 | No |
| 1499 | 1597 | 1597.0 | 51.35 | 51.4 | The stress response in fish. | S E Wendelaar Bonga | Physiol Rev | 1997 | 9234959 | No |
| 1500 | 1595 | 1595.0 | 0.0 | 0.0 | Interhemispheric differences in the localization of psychological processes in man. | B Milner | Br Med Bull | 1971 | 4937273 | No |
| 1501 | 1595 | 1595.0 | 34.57 | 34.6 | The caveolae membrane system. | R G Anderson | Annu Rev Biochem | 1998 | 9759488 | No |
| 1502 | 3189 | 1594.5 | 63.06 | 31.5 | Automated MAD and MIR structure solution. | T C Terwilliger, J Berendzen | Acta Crystallogr D Biol Crystallogr | 1999 | 10089316 | Yes |
| 1503 | 1594 | 1594.0 | 40.03 | 40.0 | Tumor necrosis factor (TNF). | L J Old | Science | 1985 | 2413547 | Yes |
| 1504 | 3188 | 1594.0 | 113.72 | 56.9 | Avoiding false positives with PCR. | S Kwok, R Higuchi | Nature | 1989 | 2716852 | Yes |
| 1505 | 1593 | 1593.0 | 0.0 | 0.0 | The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. | A G Pearse | J Histochem Cytochem | 1969 | 4143745 | No |
| 1506 | 3184 | 1592.0 | 67.68 | 33.8 | A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. | D Wessel, U I Flügge | Anal Biochem | 1984 | 6731838 | Yes |
| 1507 | 1591 | 1591.0 | 31.71 | 31.7 | An analysis of vertebrate mRNA sequences: intimations of translational control. | M Kozak | J Cell Biol | 1991 | 1955461 | No |
| 1508 | 3182 | 1591.0 | 125.21 | 62.6 | The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. | A J Stunkard, S Messick | J Psychosom Res | 1985 | 3981480 | Yes |
| 1509 | 4771 | 1590.3 | 107.61 | 35.9 | An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. | J K Eng, A L McCormack, J R Yates | J Am Soc Mass Spectrom | 1994 | 24226387 | Yes |
| 1510 | 1590 | 1590.0 | 40.38 | 40.4 | Cellular basis of working memory. | P S Goldman-Rakic | Neuron | 1995 | 7695894 | No |
| 1511 | 1590 | 1590.0 | 59.64 | 59.6 | Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. | Lutz Ackermann | Chem Rev | 2011 | 21391562 | Yes |
| 1512 | 1588 | 1588.0 | 0.0 | 0.0 | Fluorescence energy transfer as a spectroscopic ruler. | L Stryer | Annu Rev Biochem | 1978 | 354506 | No |
| 1513 | 3176 | 1588.0 | 68.0 | 34.0 | Inhibitors of mammalian G1 cyclin-dependent kinases. | C J Sherr, J M Roberts | Genes Dev | 1995 | 7758941 | No |
| 1514 | 1586 | 1586.0 | 72.16 | 72.2 | Mood and memory. | G H Bower | Am Psychol | 1981 | 7224324 | Yes |
| 1515 | 4756 | 1585.3 | 191.5 | 63.8 | The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. | C A McHorney, J E Ware, A E Raczek | Med Care | 1993 | 8450681 | Yes |
| 1516 | 1585 | 1585.0 | 0.0 | 0.0 | Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. | B Hille | J Gen Physiol | 1977 | 300786 | Yes |
| 1517 | 1585 | 1585.0 | 45.68 | 45.7 | Ionic dependence of glutamate neurotoxicity. | D W Choi | J Neurosci | 1987 | 2880938 | Yes |
| 1518 | 1585 | 1585.0 | 30.93 | 30.9 | Switching and signaling at the telomere. | E H Blackburn | Cell | 2001 | 11572773 | No |
| 1519 | 3168 | 1584.0 | 96.01 | 48.0 | Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. | M Karas, F Hillenkamp | Anal Chem | 1988 | 3239801 | Yes |
| 1520 | 1583 | 1583.0 | 57.53 | 57.5 | Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. | P Holzer | Pharmacol Rev | 1991 | 1852779 | No |
| 1521 | 1583 | 1583.0 | 55.7 | 55.7 | Frontal-subcortical circuits and human behavior. | J L Cummings | Arch Neurol | 1993 | 8352676 | No |
| 1522 | 3165 | 1582.5 | 210.82 | 105.4 | A clinical method of functional assessment of the shoulder. | C R Constant, A H Murley | Clin Orthop Relat Res | 1987 | 3791738 | Yes |
| 1523 | 17405 | 1582.3 | 461.71 | 42.0 | PLINK: a tool set for whole-genome association and population-based linkage analyses. | Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C Sham | Am J Hum Genet | 2007 | 17701901 | Yes |
| 1524 | 1582 | 1582.0 | 46.21 | 46.2 | Porous scaffold design for tissue engineering. | Scott J Hollister | Nat Mater | 2005 | 16003400 | No |
| 1525 | 3164 | 1582.0 | 81.53 | 40.8 | Origins and Mechanisms of miRNAs and siRNAs. | Richard W Carthew, Erik J Sontheimer | Cell | 2009 | 19239886 | No |
| 1526 | 4745 | 1581.7 | 127.72 | 42.6 | Median-joining networks for inferring intraspecific phylogenies. | H J Bandelt, P Forster, A Röhl | Mol Biol Evol | 1999 | 10331250 | Yes |
| 1527 | 9490 | 1581.7 | 291.09 | 48.5 | Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. | Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E Walters | Arch Gen Psychiatry | 2005 | 15939837 | Yes |
| 1528 | 3163 | 1581.5 | 78.53 | 39.3 | A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. | S Tabor, C C Richardson | Proc Natl Acad Sci U S A | 1985 | 3156376 | Yes |
| 1529 | 1581 | 1581.0 | 49.46 | 49.5 | Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. | F Rousset | Genetics | 1997 | 9093870 | Yes |
| 1530 | 1581 | 1581.0 | 42.84 | 42.8 | Pathogen recognition and inflammatory signaling in innate immune defenses. | Trine H Mogensen | Clin Microbiol Rev | 2009 | 19366914 | No |
| 1531 | 1580 | 1580.0 | 52.8 | 52.8 | Archaea in coastal marine environments. | E F DeLong | Proc Natl Acad Sci U S A | 1992 | 1608980 | Yes |
| 1532 | 1580 | 1580.0 | 30.24 | 30.2 | Germinal centers. | I C MacLennan | Annu Rev Immunol | 1994 | 8011279 | No |
| 1533 | 3158 | 1579.0 | 103.7 | 51.9 | Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. | Stephen M Smith, Thomas E Nichols | Neuroimage | 2009 | 18501637 | Yes |
| 1534 | 1578 | 1578.0 | 34.54 | 34.5 | On finding all suboptimal foldings of an RNA molecule. | M Zuker | Science | 1989 | 2468181 | No |
| 1535 | 1578 | 1578.0 | 0.0 | 0.0 | The inverse care law. | J T Hart | Lancet | 1971 | 4100731 | Yes |
| 1536 | 3156 | 1578.0 | 89.0 | 44.5 | Polyamines. | C W Tabor, H Tabor | Annu Rev Biochem | 1984 | 6206782 | No |
| 1537 | 1578 | 1578.0 | 34.52 | 34.5 | Neuronal calcium signaling. | M J Berridge | Neuron | 1998 | 9697848 | No |
| 1538 | 1577 | 1577.0 | 47.05 | 47.0 | Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. | Ralph A Defronzo | Diabetes | 2009 | 19336687 | No |
| 1539 | 3153 | 1576.5 | 97.73 | 48.9 | Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. | D S Bredt, S H Snyder | Proc Natl Acad Sci U S A | 1990 | 1689048 | Yes |
| 1540 | 1576 | 1576.0 | 0.0 | 0.0 | Regulation of noradrenaline release by presynaptic receptor systems. | K Starke | Rev Physiol Biochem Pharmacol | 1977 | 14389 | No |
| 1541 | 1576 | 1576.0 | 39.67 | 39.7 | Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. | Z Yang | J Mol Evol | 1994 | 7932792 | Yes |
| 1542 | 6303 | 1575.8 | 141.21 | 35.3 | MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. | Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi Miyata | Nucleic Acids Res | 2002 | 12136088 | Yes |
| 1543 | 3151 | 1575.5 | 71.93 | 36.0 | The epigenomics of cancer. | Peter A Jones, Stephen B Baylin | Cell | 2007 | 17320506 | No |
| 1544 | 4721 | 1573.7 | 134.66 | 44.9 | Cell death: the significance of apoptosis. | A H Wyllie, J F Kerr, A R Currie | Int Rev Cytol | 1980 | 7014501 | No |
| 1545 | 4720 | 1573.3 | 0.0 | 0.0 | Impact of Event Scale: a measure of subjective stress. | M Horowitz, N Wilner, W Alvarez | Psychosom Med | 1979 | 472086 | Yes |
| 1546 | 1573 | 1573.0 | 0.0 | 0.0 | Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. | W H Oldendorf | Am J Physiol | 1971 | 5124307 | Yes |
| 1547 | 1573 | 1573.0 | 45.57 | 45.6 | The in vitro micronucleus technique. | M Fenech | Mutat Res | 2000 | 11113469 | No |
| 1548 | 1572 | 1572.0 | 52.38 | 52.4 | Biology of interleukin 1. | C A Dinarello | FASEB J | 1988 | 3277884 | No |
| 1549 | 1572 | 1572.0 | 42.76 | 42.8 | THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. | Kozi Asada | Annu Rev Plant Physiol Plant Mol Biol | 1999 | 15012221 | Yes |
| 1550 | 3142 | 1571.0 | 103.58 | 51.8 | Separate visual pathways for perception and action. | M A Goodale, A D Milner | Trends Neurosci | 1992 | 1374953 | No |
| 1551 | 1571 | 1571.0 | 40.64 | 40.6 | Molecular biology of prion diseases. | S B Prusiner | Science | 1991 | 1675487 | No |
| 1552 | 1571 | 1571.0 | 0.0 | 0.0 | Discharge patterns and functional organization of mammalian retina. | S W Kuffler | J Neurophysiol | 1953 | 13035466 | Yes |
| 1553 | 1571 | 1571.0 | 36.52 | 36.5 | AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. | D Grahame Hardie | Nat Rev Mol Cell Biol | 2007 | 17712357 | No |
| 1554 | 1570 | 1570.0 | 45.25 | 45.2 | Oxidative stress: oxidants and antioxidants. | H Sies | Exp Physiol | 1997 | 9129943 | No |
| 1555 | 1569 | 1569.0 | 50.73 | 50.7 | Cellular defenses against damage from reactive oxygen species. | B P Yu | Physiol Rev | 1994 | 8295932 | No |
| 1556 | 1569 | 1569.0 | 97.0 | 97.0 | The antibiotic resistance crisis: part 1: causes and threats. | C Lee Ventola | P T | 2015 | 25859123 | Yes |
| 1557 | 1568 | 1568.0 | 35.68 | 35.7 | The proto-oncogene Bcl-2 and its role in regulating apoptosis. | G Kroemer | Nat Med | 1997 | 9176486 | No |
| 1558 | 1566 | 1566.0 | 39.8 | 39.8 | Growth of the plant cell wall. | Daniel J Cosgrove | Nat Rev Mol Cell Biol | 2005 | 16261190 | No |
| 1559 | 1566 | 1566.0 | 0.0 | 0.0 | The estimation of phosphorus. | R J Allen | Biochem J | 1940 | 16747230 | Yes |
| 1560 | 1566 | 1566.0 | 88.21 | 88.2 | Deep learning in neural networks: an overview. | Jürgen Schmidhuber | Neural Netw | 2015 | 25462637 | No |
| 1561 | 1565 | 1565.0 | 41.83 | 41.8 | Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. | D A Dougherty | Science | 1996 | 8539615 | No |
| 1562 | 1565 | 1565.0 | 27.69 | 27.7 | Cell cycle checkpoint signaling through the ATM and ATR kinases. | R T Abraham | Genes Dev | 2001 | 11544175 | No |
| 1563 | 7824 | 1564.8 | 203.61 | 40.7 | Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. | Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan Hsu | N Engl J Med | 2004 | 15385656 | Yes |
| 1564 | 3128 | 1564.0 | 163.62 | 81.8 | Interrater reliability of a modified Ashworth scale of muscle spasticity. | R W Bohannon, M B Smith | Phys Ther | 1987 | 3809245 | Yes |
| 1565 | 1564 | 1564.0 | 37.18 | 37.2 | The hippo signaling pathway in development and cancer. | Duojia Pan | Dev Cell | 2010 | 20951342 | No |
| 1566 | 1563 | 1563.0 | 0.0 | 0.0 | Synaptic density in human frontal cortex - developmental changes and effects of aging. | P R Huttenlocher | Brain Res | 1979 | 427544 | Yes |
| 1567 | 1563 | 1563.0 | 45.79 | 45.8 | The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. | R R Llinás | Science | 1988 | 3059497 | No |
| 1568 | 1563 | 1563.0 | 39.72 | 39.7 | Lead- and drug-like compounds: the rule-of-five revolution. | Christopher A Lipinski | Drug Discov Today Technol | 2004 | 24981612 | Yes |
| 1569 | 3125 | 1562.5 | 0.0 | 0.0 | The structure of coping. | L I Pearlin, C Schooler | J Health Soc Behav | 1978 | 649936 | Yes |
| 1570 | 1562 | 1562.0 | 36.24 | 36.2 | Trastuzumab--mechanism of action and use in clinical practice. | Clifford A Hudis | N Engl J Med | 2007 | 17611206 | No |
| 1571 | 1562 | 1562.0 | 67.4 | 67.4 | The emerging role of lncRNAs in cancer. | Maite Huarte | Nat Med | 2015 | 26540387 | No |
| 1572 | 3123 | 1561.5 | 68.91 | 34.5 | Why do cancers have high aerobic glycolysis? | Robert A Gatenby, Robert J Gillies | Nat Rev Cancer | 2004 | 15516961 | No |
| 1573 | 1560 | 1560.0 | 45.3 | 45.3 | Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. | S Hakomori | Annu Rev Biochem | 1981 | 7023369 | No |
| 1574 | 1560 | 1560.0 | 42.8 | 42.8 | The complete general secretory pathway in gram-negative bacteria. | A P Pugsley | Microbiol Rev | 1993 | 8096622 | No |
| 1575 | 9358 | 1559.7 | 197.15 | 32.9 | Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. | A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C Mello | Nature | 1998 | 9486653 | Yes |
| 1576 | 6238 | 1559.5 | 230.79 | 57.7 | SignalP 4.0: discriminating signal peptides from transmembrane regions. | Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik Nielsen | Nat Methods | 2011 | 21959131 | Yes |
| 1577 | 3118 | 1559.0 | 91.31 | 45.7 | Oxidative stress, glutamate, and neurodegenerative disorders. | J T Coyle, P Puttfarcken | Science | 1993 | 7901908 | No |
| 1578 | 3117 | 1558.5 | 71.24 | 35.6 | Fibroblasts in cancer. | Raghu Kalluri, Michael Zeisberg | Nat Rev Cancer | 2006 | 16572188 | No |
| 1579 | 1558 | 1558.0 | 41.81 | 41.8 | Molecular bases of the acute coronary syndromes. | P Libby | Circulation | 1995 | 7758192 | No |
| 1580 | 1558 | 1558.0 | 0.0 | 0.0 | A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. | B C Hummel | Can J Biochem Physiol | 1959 | 14405350 | Yes |
| 1581 | 9339 | 1556.5 | 220.48 | 36.7 | Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. | D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuire | Science | 1987 | 3798106 | Yes |
| 1582 | 1555 | 1555.0 | 0.0 | 0.0 | Cognitive maps in rats and men. | E C Tolman | Psychol Rev | 1948 | 18870876 | Yes |
| 1583 | 1554 | 1554.0 | 51.56 | 51.6 | Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). | M N Marsh | Gastroenterology | 1992 | 1727768 | No |
| 1584 | 1554 | 1554.0 | 66.82 | 66.8 | A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. | D J Schuirmann | J Pharmacokinet Biopharm | 1987 | 3450848 | Yes |
| 1585 | 1553 | 1553.0 | 60.33 | 60.3 | Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. | P Holzer | Neuroscience | 1988 | 3288903 | No |
| 1586 | 1553 | 1553.0 | 39.44 | 39.4 | Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. | M J Meaney | Annu Rev Neurosci | 2001 | 11520931 | No |
| 1587 | 1553 | 1553.0 | 44.69 | 44.7 | What we can do and what we cannot do with fMRI. | Nikos K Logothetis | Nature | 2008 | 18548064 | No |
| 1588 | 3103 | 1551.5 | 99.84 | 49.9 | Molecular mechanisms and clinical applications of angiogenesis. | Peter Carmeliet, Rakesh K Jain | Nature | 2011 | 21593862 | No |
| 1589 | 1551 | 1551.0 | 50.8 | 50.8 | Health consequences of obesity in youth: childhood predictors of adult disease. | W H Dietz | Pediatrics | 1998 | 12224658 | No |
| 1590 | 4651 | 1550.3 | 117.45 | 39.1 | Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. | Earl S Ford, Wayne H Giles, William H Dietz | JAMA | 2002 | 11790215 | Yes |
| 1591 | 1550 | 1550.0 | 37.95 | 38.0 | HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. | J M Coffin | Science | 1995 | 7824947 | Yes |
| 1592 | 1550 | 1550.0 | 48.65 | 48.6 | Constructions of masculinity and their influence on men's well-being: a theory of gender and health. | W H Courtenay | Soc Sci Med | 2000 | 10741575 | No |
| 1593 | 3099 | 1549.5 | 97.28 | 48.6 | Alzheimer's disease. | Henry W Querfurth, Frank M LaFerla | N Engl J Med | 2010 | 20107219 | No |
| 1594 | 4648 | 1549.3 | 0.0 | 0.0 | A highly sensitive adenylate cyclase assay. | Y Salomon, C Londos, M Rodbell | Anal Biochem | 1974 | 4827395 | Yes |
| 1595 | 1549 | 1549.0 | 33.08 | 33.1 | Oxidative stress shortens telomeres. | Thomas von Zglinicki | Trends Biochem Sci | 2002 | 12114022 | Yes |
| 1596 | 1549 | 1549.0 | 0.0 | 0.0 | The recurrence of intracranial meningiomas after surgical treatment. | D Simpson | J Neurol Neurosurg Psychiatry | 1957 | 13406590 | Yes |
| 1597 | 3094 | 1547.0 | 64.6 | 32.3 | Upstream and downstream of mTOR. | Nissim Hay, Nahum Sonenberg | Genes Dev | 2004 | 15314020 | No |
| 1598 | 9277 | 1546.2 | 322.55 | 53.8 | Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. | L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R Tannenbaum | Anal Biochem | 1982 | 7181105 | Yes |
| 1599 | 3091 | 1545.5 | 75.59 | 37.8 | Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. | Robert Visse, Hideaki Nagase | Circ Res | 2003 | 12730128 | No |
| 1600 | 3091 | 1545.5 | 76.56 | 38.3 | The BCL-2 protein family: opposing activities that mediate cell death. | Richard J Youle, Andreas Strasser | Nat Rev Mol Cell Biol | 2008 | 18097445 | No |
| 1601 | 4636 | 1545.3 | 104.04 | 34.7 | Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. | M A Frohman, M K Dush, G R Martin | Proc Natl Acad Sci U S A | 1988 | 2461560 | Yes |
| 1602 | 1545 | 1545.0 | 36.62 | 36.6 | Getting formal with dopamine and reward. | Wolfram Schultz | Neuron | 2002 | 12383780 | No |
| 1603 | 1545 | 1545.0 | 31.18 | 31.2 | Network motifs: theory and experimental approaches. | Uri Alon | Nat Rev Genet | 2007 | 17510665 | No |
| 1604 | 1544 | 1544.0 | 28.23 | 28.2 | Altering the genome by homologous recombination. | M R Capecchi | Science | 1989 | 2660260 | No |
| 1605 | 1544 | 1544.0 | 70.87 | 70.9 | The contribution of low birth weight to infant mortality and childhood morbidity. | M C McCormick | N Engl J Med | 1985 | 3880598 | No |
| 1606 | 1544 | 1544.0 | 71.31 | 71.3 | Measurement of health state utilities for economic appraisal. | G W Torrance | J Health Econ | 1986 | 10311607 | No |
| 1607 | 1543 | 1543.0 | 0.0 | 0.0 | Statistical analysis of enzyme kinetic data. | W W Cleland | Methods Enzymol | 1979 | 502857 | Yes |
| 1608 | 1542 | 1542.0 | 0.0 | 0.0 | Dithiothreitol, A New Protective Reagent For Sh Groups. | W W Cleland | Biochemistry | 1964 | 14192894 | Yes |
| 1609 | 1542 | 1542.0 | 53.77 | 53.8 | Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. | Berislav V Zlokovic | Nat Rev Neurosci | 2011 | 22048062 | No |
| 1610 | 1541 | 1541.0 | 57.65 | 57.6 | Aging, natural death, and the compression of morbidity. | J F Fries | N Engl J Med | 1980 | 7383070 | Yes |
| 1611 | 1541 | 1541.0 | 30.41 | 30.4 | Neuroblastoma: biological insights into a clinical enigma. | Garrett M Brodeur | Nat Rev Cancer | 2003 | 12612655 | No |
| 1612 | 1540 | 1540.0 | 57.23 | 57.2 | The linear-quadratic formula and progress in fractionated radiotherapy. | J F Fowler | Br J Radiol | 1989 | 2670032 | No |
| 1613 | 1540 | 1540.0 | 39.07 | 39.1 | Tricine-SDS-PAGE. | Hermann Schägger | Nat Protoc | 2006 | 17406207 | Yes |
| 1614 | 3079 | 1539.5 | 66.0 | 33.0 | Signaling to NF-kappaB. | Matthew S Hayden, Sankar Ghosh | Genes Dev | 2004 | 15371334 | No |
| 1615 | 3079 | 1539.5 | 74.64 | 37.3 | Shared principles in NF-kappaB signaling. | Matthew S Hayden, Sankar Ghosh | Cell | 2008 | 18267068 | No |
| 1616 | 1539 | 1539.0 | 0.0 | 0.0 | Which elements are excited in electrical stimulation of mammalian central nervous system: a review. | J B Ranck | Brain Res | 1975 | 1102064 | No |
| 1617 | 1539 | 1539.0 | 54.36 | 54.4 | Cognitive reserve. | Yaakov Stern | Neuropsychologia | 2009 | 19467352 | No |
| 1618 | 1538 | 1538.0 | 29.41 | 29.4 | How cells read TGF-beta signals. | J Massagué | Nat Rev Mol Cell Biol | 2000 | 11252892 | No |
| 1619 | 4613 | 1537.7 | 118.56 | 39.5 | Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. | Prateek Kumar, Steven Henikoff, Pauline C Ng | Nat Protoc | 2009 | 19561590 | Yes |
| 1620 | 3075 | 1537.5 | 0.0 | 0.0 | A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. | G Schmidt, S J Thannhauser | J Biol Chem | 1945 | 21005717 | Yes |
| 1621 | 1537 | 1537.0 | 34.68 | 34.7 | Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. | C Taswell | J Immunol | 1981 | 7009746 | Yes |
| 1622 | 1537 | 1537.0 | 36.51 | 36.5 | Thiazolidinediones. | Hannele Yki-Järvinen | N Engl J Med | 2004 | 15356308 | No |
| 1623 | 3073 | 1536.5 | 103.47 | 51.7 | The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. | R Doll, R Peto | J Natl Cancer Inst | 1981 | 7017215 | No |
| 1624 | 7678 | 1535.6 | 176.17 | 35.2 | Stages of embryonic development of the zebrafish. | C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F Schilling | Dev Dyn | 1995 | 8589427 | Yes |
| 1625 | 3071 | 1535.5 | 0.0 | 0.0 | Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. | C B Lozzio, B B Lozzio | Blood | 1975 | 163658 | Yes |
| 1626 | 1535 | 1535.0 | 60.26 | 60.3 | Probiotics in man and animals. | R Fuller | J Appl Bacteriol | 1989 | 2666378 | No |
| 1627 | 1535 | 1535.0 | 44.93 | 44.9 | The basal ganglia: focused selection and inhibition of competing motor programs. | J W Mink | Prog Neurobiol | 1996 | 9004351 | No |
| 1628 | 1534 | 1534.0 | 0.0 | 0.0 | Antigen-Antibody Crossed Electrophoresis. | C B Laurell | Anal Biochem | 1965 | 14302464 | Yes |
| 1629 | 3067 | 1533.5 | 0.0 | 0.0 | Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. | D B Dill, D L Costill | J Appl Physiol | 1974 | 4850854 | Yes |
| 1630 | 1533 | 1533.0 | 39.12 | 39.1 | Early signals in the mitogenic response. | E Rozengurt | Science | 1986 | 3018928 | No |
| 1631 | 3066 | 1533.0 | 73.9 | 37.0 | Human mesenchymal stem cells modulate allogeneic immune cell responses. | Sudeepta Aggarwal, Mark F Pittenger | Blood | 2005 | 15494428 | Yes |
| 1632 | 3065 | 1532.5 | 0.0 | 0.0 | New Giemsa method for the differential staining of sister chromatids. | P Perry, S Wolff | Nature | 1974 | 4138930 | Yes |
| 1633 | 1532 | 1532.0 | 30.72 | 30.7 | E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. | J R Nevins | Science | 1992 | 1411535 | Yes |
| 1634 | 1532 | 1532.0 | 44.55 | 44.5 | Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. | A E Pegg | Cancer Res | 1988 | 3123052 | No |
| 1635 | 1532 | 1532.0 | 36.29 | 36.3 | Introduction to NF-kappaB: players, pathways, perspectives. | T D Gilmore | Oncogene | 2006 | 17072321 | No |
| 1636 | 3062 | 1531.0 | 60.68 | 30.3 | Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. | O Tetsu, F McCormick | Nature | 1999 | 10201372 | Yes |
| 1637 | 1531 | 1531.0 | 30.69 | 30.7 | The microRNA Registry. | Sam Griffiths-Jones | Nucleic Acids Res | 2004 | 14681370 | Yes |
| 1638 | 1529 | 1529.0 | 34.27 | 34.3 | Molecular themes in oncogenesis. | J M Bishop | Cell | 1991 | 1988146 | No |
| 1639 | 1529 | 1529.0 | 0.0 | 0.0 | An enzymic method for the trace iodination of immunoglobulins and other proteins. | J J Marchalonis | Biochem J | 1969 | 4185494 | Yes |
| 1640 | 3056 | 1528.0 | 80.83 | 40.4 | Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. | M A Nitsche, W Paulus | J Physiol | 2000 | 10990547 | Yes |
| 1641 | 3054 | 1527.0 | 63.74 | 31.9 | Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. | Gary L Johnson, Razvan Lapadat | Science | 2002 | 12471242 | No |
| 1642 | 1526 | 1526.0 | 45.5 | 45.5 | Recent advances in the biochemistry of polyamines in eukaryotes. | A E Pegg | Biochem J | 1986 | 3087344 | No |
| 1643 | 1526 | 1526.0 | 37.04 | 37.0 | A revolution in optical manipulation. | David G Grier | Nature | 2003 | 12917694 | No |
| 1644 | 1525 | 1525.0 | 0.0 | 0.0 | Application of a Theory of Enzyme Specificity to Protein Synthesis. | D E Koshland | Proc Natl Acad Sci U S A | 1958 | 16590179 | Yes |
| 1645 | 1524 | 1524.0 | 35.58 | 35.6 | Hypertrophic cardiomyopathy: a systematic review. | Barry J Maron | JAMA | 2002 | 11886323 | No |
| 1646 | 3047 | 1523.5 | 111.13 | 55.6 | The transtheoretical model of health behavior change. | J O Prochaska, W F Velicer | Am J Health Promot | 1997 | 10170434 | No |
| 1647 | 3046 | 1523.0 | 0.0 | 0.0 | Computed circular dichroism spectra for the evaluation of protein conformation. | N Greenfield, G D Fasman | Biochemistry | 1969 | 5346390 | Yes |
| 1648 | 1523 | 1523.0 | 31.19 | 31.2 | The ubiquitin-proteasome proteolytic pathway. | A Ciechanover | Cell | 1994 | 7923371 | No |
| 1649 | 1523 | 1523.0 | 37.53 | 37.5 | Recognition of errors in three-dimensional structures of proteins. | M J Sippl | Proteins | 1993 | 8108378 | Yes |
| 1650 | 1523 | 1523.0 | 38.61 | 38.6 | The corticosteroid receptor hypothesis of depression. | F Holsboer | Neuropsychopharmacology | 2000 | 11027914 | No |
| 1651 | 6090 | 1522.5 | 0.0 | 0.0 | The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. | S P Baker, B O'Neill, W Haddon, W B Long | J Trauma | 1974 | 4814394 | Yes |
| 1652 | 1522 | 1522.0 | 0.0 | 0.0 | Calcium release from the sarcoplasmic reticulum. | M Endo | Physiol Rev | 1977 | 13441 | Yes |
| 1653 | 4566 | 1522.0 | 156.42 | 52.1 | A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. | J R Le Gall, S Lemeshow, F Saulnier | JAMA | 1993 | 8254858 | Yes |
| 1654 | 3043 | 1521.5 | 92.78 | 46.4 | Unified approach for molecular dynamics and density-functional theory. | Car, Parrinello | Phys Rev Lett | 1985 | 10032153 | Yes |
| 1655 | 4564 | 1521.3 | 132.2 | 44.1 | Regularization Paths for Generalized Linear Models via Coordinate Descent. | Jerome Friedman, Trevor Hastie, Rob Tibshirani | J Stat Softw | 2010 | 20808728 | Yes |
| 1656 | 1521 | 1521.0 | 0.0 | 0.0 | Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. | H S Penefsky | J Biol Chem | 1977 | 16006 | Yes |
| 1657 | 7605 | 1521.0 | 0.0 | 0.0 | Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. | S Katz, A B Ford, R W Moskowitz, B A Jackson, M W Jaffe | JAMA | 1963 | 14044222 | Yes |
| 1658 | 1520 | 1520.0 | 47.69 | 47.7 | The role of the amygdala in fear and anxiety. | M Davis | Annu Rev Neurosci | 1992 | 1575447 | No |
| 1659 | 1519 | 1519.0 | 0.0 | 0.0 | Biological applications of ionophores. | B C Pressman | Annu Rev Biochem | 1976 | 786156 | No |
| 1660 | 1519 | 1519.0 | 41.56 | 41.6 | Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. | L A Liotta | Cancer Res | 1986 | 2998604 | No |
| 1661 | 1519 | 1519.0 | 0.0 | 0.0 | Simple memory: a theory for archicortex. | D Marr | Philos Trans R Soc Lond B Biol Sci | 1971 | 4399412 | Yes |
| 1662 | 1519 | 1519.0 | 33.8 | 33.8 | Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. | G L Semenza | Annu Rev Cell Dev Biol | 1999 | 10611972 | No |
| 1663 | 4548 | 1516.0 | 118.93 | 39.6 | The rapid generation of mutation data matrices from protein sequences. | D T Jones, W R Taylor, J M Thornton | Comput Appl Biosci | 1992 | 1633570 | Yes |
| 1664 | 1515 | 1515.0 | 0.0 | 0.0 | Some observations upon a new inhibitor of monoamine oxidase in brain tissue. | J P Johnston | Biochem Pharmacol | 1968 | 5659776 | Yes |
| 1665 | 1515 | 1515.0 | 35.19 | 35.2 | Perceptions of epigenetics. | Adrian Bird | Nature | 2007 | 17522671 | Yes |
| 1666 | 4544 | 1514.7 | 91.55 | 30.5 | T-Coffee: A novel method for fast and accurate multiple sequence alignment. | C Notredame, D G Higgins, J Heringa | J Mol Biol | 2000 | 10964570 | Yes |
| 1667 | 1514 | 1514.0 | 32.27 | 32.3 | DNA in a material world. | Nadrian C Seeman | Nature | 2003 | 12540916 | No |
| 1668 | 1513 | 1513.0 | 38.27 | 38.3 | Trophic factors and neuronal survival. | Y A Barde | Neuron | 1989 | 2697237 | No |
| 1669 | 1513 | 1513.0 | 45.86 | 45.9 | Gold-catalyzed organic reactions. | A Stephen K Hashmi | Chem Rev | 2007 | 17580975 | Yes |
| 1670 | 4538 | 1512.7 | 122.15 | 40.7 | A neural substrate of prediction and reward. | W Schultz, P Dayan, P R Montague | Science | 1997 | 9054347 | No |
| 1671 | 1512 | 1512.0 | 81.81 | 81.8 | Subjective well-being. | E Diener | Psychol Bull | 1984 | 6399758 | No |
| 1672 | 1512 | 1512.0 | 0.0 | 0.0 | Cerebral blood flow and oxygen consumption in man. | N A Lassen | Physiol Rev | 1959 | 13645234 | Yes |
| 1673 | 1511 | 1511.0 | 65.24 | 65.2 | Pro-resolving lipid mediators are leads for resolution physiology. | Charles N Serhan | Nature | 2014 | 24899309 | No |
| 1674 | 4532 | 1510.7 | 145.13 | 48.4 | Estimating the mean and variance from the median, range, and the size of a sample. | Stela Pudar Hozo, Benjamin Djulbegovic, Iztok Hozo | BMC Med Res Methodol | 2005 | 15840177 | Yes |
| 1675 | 4531 | 1510.3 | 153.76 | 51.3 | Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. | Aleksandr V Marenich, Christopher J Cramer, Donald G Truhlar | J Phys Chem B | 2009 | 19366259 | Yes |
| 1676 | 1510 | 1510.0 | 42.47 | 42.5 | Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. | Y Ben-Ari | Neuroscience | 1985 | 2859548 | No |
| 1677 | 3018 | 1509.0 | 72.28 | 36.1 | The incidence of congenital heart disease. | Julien I E Hoffman, Samuel Kaplan | J Am Coll Cardiol | 2002 | 12084585 | No |
| 1678 | 1509 | 1509.0 | 32.1 | 32.1 | Neurotrophins and their receptors: a convergence point for many signalling pathways. | Moses V Chao | Nat Rev Neurosci | 2003 | 12671646 | No |
| 1679 | 3018 | 1509.0 | 88.14 | 44.1 | The precuneus: a review of its functional anatomy and behavioural correlates. | Andrea E Cavanna, Michael R Trimble | Brain | 2006 | 16399806 | No |
| 1680 | 6033 | 1508.2 | 333.99 | 83.5 | IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. | Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang Minh | Mol Biol Evol | 2015 | 25371430 | Yes |
| 1681 | 1508 | 1508.0 | 62.69 | 62.7 | Antibiotics in the aquatic environment--a review--part I. | Klaus Kümmerer | Chemosphere | 2009 | 19185900 | No |
| 1682 | 1506 | 1506.0 | 42.08 | 42.1 | Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. | A Fabiato | Am J Physiol | 1983 | 6346892 | No |
| 1683 | 1505 | 1505.0 | 55.48 | 55.5 | Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. | Peter C Austin | Pharm Stat | 2011 | 20925139 | Yes |
| 1684 | 4513 | 1504.3 | 90.92 | 30.3 | Efficient selection for high-expression transfectants with a novel eukaryotic vector. | H Niwa, K Yamamura, J Miyazaki | Gene | 1991 | 1660837 | Yes |
| 1685 | 1504 | 1504.0 | 0.0 | 0.0 | Bias in analytic research. | D L Sackett | J Chronic Dis | 1979 | 447779 | Yes |
| 1686 | 1504 | 1504.0 | 38.62 | 38.6 | Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. | Shitij Kapur | Am J Psychiatry | 2003 | 12505794 | No |
| 1687 | 1503 | 1503.0 | 0.0 | 0.0 | Impulses and Physiological States in Theoretical Models of Nerve Membrane. | R Fitzhugh | Biophys J | 1961 | 19431309 | Yes |
| 1688 | 3004 | 1502.0 | 115.44 | 57.7 | The mini-mental state examination: a comprehensive review. | T N Tombaugh, N J McIntyre | J Am Geriatr Soc | 1992 | 1512391 | No |
| 1689 | 1500 | 1500.0 | 0.0 | 0.0 | Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. | C S Neer | J Bone Joint Surg Am | 1972 | 5054450 | Yes |
| 1690 | 1500 | 1500.0 | 0.0 | 0.0 | The Gingival Index, the Plaque Index and the Retention Index Systems. | H Löe | J Periodontol | 1967 | 5237684 | Yes |
| 1691 | 1500 | 1500.0 | 35.56 | 35.6 | A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. | D A Gewirtz | Biochem Pharmacol | 1999 | 10075079 | No |
| 1692 | 1500 | 1500.0 | 48.12 | 48.1 | Social relationships and health. | Sheldon Cohen | Am Psychol | 2004 | 15554821 | No |
| 1693 | 2999 | 1499.5 | 92.03 | 46.0 | Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. | James J Gross, Oliver P John | J Pers Soc Psychol | 2003 | 12916575 | Yes |
| 1694 | 1499 | 1499.0 | 0.0 | 0.0 | A soluble protein characteristic of the nervous system. | B W Moore | Biochem Biophys Res Commun | 1965 | 4953930 | Yes |
| 1695 | 1499 | 1499.0 | 0.0 | 0.0 | Dopamine (3-hydroxytyramine) and brain function. | O Hornykiewicz | Pharmacol Rev | 1966 | 5328389 | No |
| 1696 | 2995 | 1497.5 | 0.0 | 0.0 | Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. | R L Heath, L Packer | Arch Biochem Biophys | 1968 | 5655425 | Yes |
| 1697 | 2995 | 1497.5 | 83.67 | 41.8 | Multiple sclerosis. | Alastair Compston, Alasdair Coles | Lancet | 2008 | 18970977 | Yes |
| 1698 | 1497 | 1497.0 | 40.29 | 40.3 | Precision mapping of quantitative trait loci. | Z B Zeng | Genetics | 1994 | 8013918 | Yes |
| 1699 | 2991 | 1495.5 | 74.4 | 37.2 | Adipose tissue as an endocrine organ. | Erin E Kershaw, Jeffrey S Flier | J Clin Endocrinol Metab | 2004 | 15181022 | No |
| 1700 | 5980 | 1495.0 | 242.21 | 60.6 | 16S ribosomal DNA amplification for phylogenetic study. | W G Weisburg, S M Barns, D A Pelletier, D J Lane | J Bacteriol | 1991 | 1987160 | Yes |
| 1701 | 1495 | 1495.0 | 35.09 | 35.1 | PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. | Michael F. Thomashow | Annu Rev Plant Physiol Plant Mol Biol | 1999 | 15012220 | Yes |
| 1702 | 4484 | 1494.7 | 96.0 | 32.0 | The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. | S K Hanks, A M Quinn, T Hunter | Science | 1988 | 3291115 | No |
| 1703 | 1494 | 1494.0 | 0.0 | 0.0 | Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. | J C Unkeless | J Exp Med | 1979 | 90108 | Yes |
| 1704 | 1494 | 1494.0 | 39.36 | 39.4 | The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. | A S Fauci | Science | 1988 | 3277274 | No |
| 1705 | 5976 | 1494.0 | 150.53 | 37.6 | Improved optimization for the robust and accurate linear registration and motion correction of brain images. | Mark Jenkinson, Peter Bannister, Michael Brady, Stephen Smith | Neuroimage | 2002 | 12377157 | Yes |
| 1706 | 1493 | 1493.0 | 70.19 | 70.2 | What's in a name? Qualitative description revisited. | Margarete Sandelowski | Res Nurs Health | 2010 | 20014004 | Yes |
| 1707 | 1492 | 1492.0 | 54.35 | 54.4 | Falls in older people: epidemiology, risk factors and strategies for prevention. | Laurence Z Rubenstein | Age Ageing | 2006 | 16926202 | No |
| 1708 | 1491 | 1491.0 | 38.4 | 38.4 | Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. | B Winkel-Shirley | Plant Physiol | 2001 | 11402179 | No |
| 1709 | 2981 | 1490.5 | 0.0 | 0.0 | Lactic dehydrogenase activity in blood. | F Wroblewski, J S Ladue | Proc Soc Exp Biol Med | 1955 | 13273400 | Yes |
| 1710 | 2981 | 1490.5 | 0.0 | 0.0 | Junctional complexes in various epithelia. | M G Farquhar, G E Palade | J Cell Biol | 1963 | 13944428 | Yes |
| 1711 | 1490 | 1490.0 | 0.0 | 0.0 | Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. | S Avrameas | Immunochemistry | 1969 | 4975324 | Yes |
| 1712 | 4470 | 1490.0 | 85.55 | 28.5 | Notch signaling: cell fate control and signal integration in development. | S Artavanis-Tsakonas, M D Rand, R J Lake | Science | 1999 | 10221902 | No |
| 1713 | 1489 | 1489.0 | 53.76 | 53.8 | Dual-task interference in simple tasks: data and theory. | H Pashler | Psychol Bull | 1994 | 7972591 | No |
| 1714 | 1489 | 1489.0 | 39.53 | 39.5 | Integration, scaling, space-group assignment and post-refinement. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124693 | Yes |
| 1715 | 2977 | 1488.5 | 126.11 | 63.1 | Deciphering key features in protein structures with the new ENDscript server. | Xavier Robert, Patrice Gouet | Nucleic Acids Res | 2014 | 24753421 | Yes |
| 1716 | 1488 | 1488.0 | 0.0 | 0.0 | Atherogenesis: a postprandial phenomenon. | D B Zilversmit | Circulation | 1979 | 222498 | Yes |
| 1717 | 1488 | 1488.0 | 29.24 | 29.2 | Intrinsically unstructured proteins. | Peter Tompa | Trends Biochem Sci | 2002 | 12368089 | No |
| 1718 | 1486 | 1486.0 | 52.03 | 52.0 | Lyme disease. | A C Steere | N Engl J Med | 1989 | 2668764 | No |
| 1719 | 1485 | 1485.0 | 49.4 | 49.4 | Validation of a decisional conflict scale. | A M O'Connor | Med Decis Making | 1995 | 7898294 | Yes |
| 1720 | 2970 | 1485.0 | 60.83 | 30.4 | NF-kappaB regulation in the immune system. | Qiutang Li, Inder M Verma | Nat Rev Immunol | 2002 | 12360211 | No |
| 1721 | 2970 | 1485.0 | 67.04 | 33.5 | Complex networks orchestrate epithelial-mesenchymal transitions. | Jean Paul Thiery, Jonathan P Sleeman | Nat Rev Mol Cell Biol | 2006 | 16493418 | No |
| 1722 | 2969 | 1484.5 | 113.38 | 56.7 | Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. | Sarvajeet Singh Gill, Narendra Tuteja | Plant Physiol Biochem | 2010 | 20870416 | No |
| 1723 | 5936 | 1484.0 | 174.3 | 43.6 | Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. | B Biswal, F Z Yetkin, V M Haughton, J S Hyde | Magn Reson Med | 1995 | 8524021 | Yes |
| 1724 | 1484 | 1484.0 | 25.53 | 25.5 | Neuronal specification in the spinal cord: inductive signals and transcriptional codes. | T M Jessell | Nat Rev Genet | 2000 | 11262869 | No |
| 1725 | 2968 | 1484.0 | 103.62 | 51.8 | Palladium-catalyzed ligand-directed C-H functionalization reactions. | Thomas W Lyons, Melanie S Sanford | Chem Rev | 2010 | 20078038 | No |
| 1726 | 2966 | 1483.0 | 59.48 | 29.7 | Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. | P J Mitchell, R Tjian | Science | 1989 | 2667136 | No |
| 1727 | 1483 | 1483.0 | 0.0 | 0.0 | Amino acid difference formula to help explain protein evolution. | R Grantham | Science | 1974 | 4843792 | Yes |
| 1728 | 1483 | 1483.0 | 33.26 | 33.3 | An approximately unbiased test of phylogenetic tree selection. | Hidetoshi Shimodaira | Syst Biol | 2002 | 12079646 | Yes |
| 1729 | 1482 | 1482.0 | 33.65 | 33.6 | Tumor suppressor genes. | R A Weinberg | Science | 1991 | 1659741 | No |
| 1730 | 1482 | 1482.0 | 40.01 | 40.0 | Rheumatoid arthritis. Pathophysiology and implications for therapy. | E D Harris | N Engl J Med | 1990 | 2271017 | No |
| 1731 | 1482 | 1482.0 | 0.0 | 0.0 | Selforganization of matter and the evolution of biological macromolecules. | M Eigen | Naturwissenschaften | 1971 | 4942363 | No |
| 1732 | 1482 | 1482.0 | 36.14 | 36.1 | In vivo near-infrared fluorescence imaging. | John V Frangioni | Curr Opin Chem Biol | 2003 | 14580568 | No |
| 1733 | 1482 | 1482.0 | 0.0 | 0.0 | The colorimetric determination of phosphorus. | E J King | Biochem J | 1932 | 16744823 | Yes |
| 1734 | 4443 | 1481.0 | 124.59 | 41.5 | Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. | M Hasegawa, H Kishino, T Yano | J Mol Evol | 1985 | 3934395 | Yes |
| 1735 | 5923 | 1480.8 | 172.43 | 43.1 | Comorbidity measures for use with administrative data. | A Elixhauser, C Steiner, D R Harris, R M Coffey | Med Care | 1998 | 9431328 | Yes |
| 1736 | 2960 | 1480.0 | 66.36 | 33.2 | Cell migration: a physically integrated molecular process. | D A Lauffenburger, A F Horwitz | Cell | 1996 | 8608589 | No |
| 1737 | 1480 | 1480.0 | 0.0 | 0.0 | Simple methods for "staining with lead" at high pH in electron microscopy. | M J Karnovsky | J Biophys Biochem Cytol | 1961 | 14454024 | Yes |
| 1738 | 1480 | 1480.0 | 45.2 | 45.2 | Systemic lupus erythematosus. | George C Tsokos | N Engl J Med | 2011 | 22129255 | No |
| 1739 | 1479 | 1479.0 | 32.45 | 32.5 | From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. | W A Catterall | Neuron | 2000 | 10798388 | No |
| 1740 | 4435 | 1478.3 | 151.2 | 50.4 | Phylogenetic identification and in situ detection of individual microbial cells without cultivation. | R I Amann, W Ludwig, K H Schleifer | Microbiol Rev | 1995 | 7535888 | No |
| 1741 | 2956 | 1478.0 | 84.56 | 42.3 | Diarrheagenic Escherichia coli. | J P Nataro, J B Kaper | Clin Microbiol Rev | 1998 | 9457432 | No |
| 1742 | 2956 | 1478.0 | 93.15 | 46.6 | Mechanisms of salinity tolerance. | Rana Munns, Mark Tester | Annu Rev Plant Biol | 2008 | 18444910 | No |
| 1743 | 1478 | 1478.0 | 51.12 | 51.1 | Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. | Joseph J Volpe | Lancet Neurol | 2009 | 19081519 | No |
| 1744 | 2954 | 1477.0 | 0.0 | 0.0 | Diabetes and cardiovascular disease. The Framingham study. | W B Kannel, D L McGee | JAMA | 1979 | 430798 | Yes |
| 1745 | 1477 | 1477.0 | 42.6 | 42.6 | Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. | P A Bradford | Clin Microbiol Rev | 2001 | 11585791 | No |
| 1746 | 1476 | 1476.0 | 0.0 | 0.0 | Isolated removal of hypothalamic or other brain nuclei of the rat. | M Palkovits | Brain Res | 1973 | 4747772 | Yes |
| 1747 | 1476 | 1476.0 | 29.27 | 29.3 | Protein degradation and protection against misfolded or damaged proteins. | Alfred L Goldberg | Nature | 2003 | 14685250 | No |
| 1748 | 1475 | 1475.0 | 49.37 | 49.4 | Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. | H J Gundersen | J Microsc | 1986 | 3761363 | Yes |
| 1749 | 1475 | 1475.0 | 47.1 | 47.1 | Evidence for a central component of post-injury pain hypersensitivity. | C J Woolf | Nature | 1983 | 6656869 | Yes |
| 1750 | 1475 | 1475.0 | 31.77 | 31.8 | Drug discovery: a historical perspective. | J Drews | Science | 2000 | 10720314 | No |
| 1751 | 14747 | 1474.7 | 362.79 | 36.3 | Multilineage potential of adult human mesenchymal stem cells. | M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R Marshak | Science | 1999 | 10102814 | Yes |
| 1752 | 1474 | 1474.0 | 0.0 | 0.0 | Nutrition needs of mammalian cells in tissue culture. | H Eagle | Science | 1955 | 13255879 | Yes |
| 1753 | 1474 | 1474.0 | 33.69 | 33.7 | Mechanisms of bone metastasis. | G David Roodman | N Engl J Med | 2004 | 15084698 | No |
| 1754 | 2946 | 1473.0 | 56.48 | 28.2 | The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. | Michael H Glickman, Aaron Ciechanover | Physiol Rev | 2002 | 11917093 | No |
| 1755 | 1472 | 1472.0 | 33.74 | 33.7 | Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. | M B Luskin | Neuron | 1993 | 8338665 | Yes |
| 1756 | 2943 | 1471.5 | 108.52 | 54.3 | Pain assessment: global use of the Brief Pain Inventory. | C S Cleeland, K M Ryan | Ann Acad Med Singap | 1994 | 8080219 | No |
| 1757 | 1470 | 1470.0 | 39.88 | 39.9 | Redox signaling: nitrosylation and related target interactions of nitric oxide. | J S Stamler | Cell | 1994 | 7923362 | No |
| 1758 | 1470 | 1470.0 | 56.17 | 56.2 | Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. | Virginia A Moyer | Ann Intern Med | 2012 | 22801674 | No |
| 1759 | 2939 | 1469.5 | 87.56 | 43.8 | An information-maximization approach to blind separation and blind deconvolution. | A J Bell, T J Sejnowski | Neural Comput | 1995 | 7584893 | Yes |
| 1760 | 2939 | 1469.5 | 86.27 | 43.1 | EQ-5D: a measure of health status from the EuroQol Group. | R Rabin, F de Charro | Ann Med | 2001 | 11491192 | No |
| 1761 | 1469 | 1469.0 | 37.52 | 37.5 | Type I diabetes mellitus. A chronic autoimmune disease. | G S Eisenbarth | N Engl J Med | 1986 | 3517648 | No |
| 1762 | 1469 | 1469.0 | 28.98 | 29.0 | Protein kinases--the major drug targets of the twenty-first century? | Philip Cohen | Nat Rev Drug Discov | 2002 | 12120282 | No |
| 1763 | 1469 | 1469.0 | 35.43 | 35.4 | Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). | K M Fox | Lancet | 2003 | 13678872 | Yes |
| 1764 | 4406 | 1468.7 | 109.57 | 36.5 | Two-photon laser scanning fluorescence microscopy. | W Denk, J H Strickler, W W Webb | Science | 1990 | 2321027 | Yes |
| 1765 | 4405 | 1468.3 | 0.0 | 0.0 | Hydroperoxide metabolism in mammalian organs. | B Chance, H Sies, A Boveris | Physiol Rev | 1979 | 37532 | Yes |
| 1766 | 4405 | 1468.3 | 182.85 | 60.9 | Molecular mechanisms of epithelial-mesenchymal transition. | Samy Lamouille, Jian Xu, Rik Derynck | Nat Rev Mol Cell Biol | 2014 | 24556840 | No |
| 1767 | 5871 | 1467.8 | 0.0 | 0.0 | A rating scale for mania: reliability, validity and sensitivity. | R C Young, J T Biggs, V E Ziegler, D A Meyer | Br J Psychiatry | 1978 | 728692 | Yes |
| 1768 | 1467 | 1467.0 | 0.0 | 0.0 | The mechanism of muscular contraction. | H E Huxley | Science | 1969 | 4181952 | No |
| 1769 | 1467 | 1467.0 | 40.7 | 40.7 | Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. | J A Beavo | Physiol Rev | 1995 | 7480160 | No |
| 1770 | 1467 | 1467.0 | 0.0 | 0.0 | Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. | R W Sperry | Proc Natl Acad Sci U S A | 1963 | 14077501 | Yes |
| 1771 | 2934 | 1467.0 | 118.39 | 59.2 | Regulation of microRNA biogenesis. | Minju Ha, V Narry Kim | Nat Rev Mol Cell Biol | 2014 | 25027649 | No |
| 1772 | 4400 | 1466.7 | 0.0 | 0.0 | The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. | J T Dodge, C Mitchell, D J Hanahan | Arch Biochem Biophys | 1963 | 14028302 | Yes |
| 1773 | 2933 | 1466.5 | 103.08 | 51.5 | Neurocircuitry of addiction. | George F Koob, Nora D Volkow | Neuropsychopharmacology | 2010 | 19710631 | No |
| 1774 | 2932 | 1466.0 | 0.0 | 0.0 | A general method for isolation of high molecular weight DNA from eukaryotes. | N Blin, D W Stafford | Nucleic Acids Res | 1976 | 987581 | Yes |
| 1775 | 1466 | 1466.0 | 53.66 | 53.7 | The case-crossover design: a method for studying transient effects on the risk of acute events. | M Maclure | Am J Epidemiol | 1991 | 1985444 | Yes |
| 1776 | 1466 | 1466.0 | 29.63 | 29.6 | Immunosuppressive networks in the tumour environment and their therapeutic relevance. | Weiping Zou | Nat Rev Cancer | 2005 | 15776005 | No |
| 1777 | 1465 | 1465.0 | 34.54 | 34.5 | Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. | S C Manolagas | Endocr Rev | 2000 | 10782361 | No |
| 1778 | 1465 | 1465.0 | 30.45 | 30.4 | Regulatory T cells, tumour immunity and immunotherapy. | Weiping Zou | Nat Rev Immunol | 2006 | 16557261 | No |
| 1779 | 2929 | 1464.5 | 63.28 | 31.6 | The Ki-67 protein: from the known and the unknown. | T Scholzen, J Gerdes | J Cell Physiol | 2000 | 10653597 | No |
| 1780 | 2928 | 1464.0 | 56.38 | 28.2 | Mutations affecting segment number and polarity in Drosophila. | C Nüsslein-Volhard, E Wieschaus | Nature | 1980 | 6776413 | Yes |
| 1781 | 1464 | 1464.0 | 29.55 | 29.6 | Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. | D I Svergun | Biophys J | 1999 | 10354416 | Yes |
| 1782 | 1464 | 1464.0 | 35.32 | 35.3 | Neurovascular regulation in the normal brain and in Alzheimer's disease. | Costantino Iadecola | Nat Rev Neurosci | 2004 | 15100718 | No |
| 1783 | 1463 | 1463.0 | 0.0 | 0.0 | Stimulated acoustic emissions from within the human auditory system. | D T Kemp | J Acoust Soc Am | 1978 | 744838 | Yes |
| 1784 | 2926 | 1463.0 | 61.13 | 30.6 | Toll-like receptor control of the adaptive immune responses. | Akiko Iwasaki, Ruslan Medzhitov | Nat Immunol | 2004 | 15454922 | No |
| 1785 | 5850 | 1462.5 | 0.0 | 0.0 | A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. | M A Markwell, S M Haas, L L Bieber, N E Tolbert | Anal Biochem | 1978 | 98070 | Yes |
| 1786 | 2925 | 1462.5 | 68.76 | 34.4 | The human plasma proteome: history, character, and diagnostic prospects. | N Leigh Anderson, Norman G Anderson | Mol Cell Proteomics | 2002 | 12488461 | No |
| 1787 | 5847 | 1461.8 | 252.1 | 63.0 | An inventory for measuring clinical anxiety: psychometric properties. | A T Beck, N Epstein, G Brown, R A Steer | J Consult Clin Psychol | 1988 | 3204199 | Yes |
| 1788 | 2923 | 1461.5 | 63.1 | 31.6 | Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. | E Krissinel, K Henrick | Acta Crystallogr D Biol Crystallogr | 2004 | 15572779 | Yes |
| 1789 | 1461 | 1461.0 | 39.42 | 39.4 | External validity of randomised controlled trials: "to whom do the results of this trial apply?". | Peter M Rothwell | Lancet | 2005 | 15639683 | Yes |
| 1790 | 1461 | 1461.0 | 36.45 | 36.5 | Insulin and insulin-like growth factor signalling in neoplasia. | Michael Pollak | Nat Rev Cancer | 2008 | 19029956 | No |
| 1791 | 1460 | 1460.0 | 0.0 | 0.0 | Ionic blockage of sodium channels in nerve. | A M Woodhull | J Gen Physiol | 1973 | 4541078 | Yes |
| 1792 | 2920 | 1460.0 | 57.62 | 28.8 | Missing pieces in the NF-kappaB puzzle. | Sankar Ghosh, Michael Karin | Cell | 2002 | 11983155 | No |
| 1793 | 1460 | 1460.0 | 37.06 | 37.1 | The biology of incretin hormones. | Daniel J Drucker | Cell Metab | 2006 | 16517403 | No |
| 1794 | 5838 | 1459.5 | 119.53 | 29.9 | A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. | B M Bolstad, R A Irizarry, M Astrand, T P Speed | Bioinformatics | 2003 | 12538238 | Yes |
| 1795 | 1459 | 1459.0 | 0.0 | 0.0 | Defective repair replication of DNA in xeroderma pigmentosum. | J E Cleaver | Nature | 1968 | 5655953 | Yes |
| 1796 | 1459 | 1459.0 | 67.18 | 67.2 | The structure and properties of the sense of coherence scale. | A Antonovsky | Soc Sci Med | 1993 | 8480217 | Yes |
| 1797 | 1459 | 1459.0 | 45.78 | 45.8 | Domino Reactions in Organic Synthesis. | Lutz F. Tietze | Chem Rev | 1996 | 11848746 | Yes |
| 1798 | 2918 | 1459.0 | 0.0 | 0.0 | A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. | A H Anton, D F Sayre | J Pharmacol Exp Ther | 1962 | 14013351 | Yes |
| 1799 | 8749 | 1458.2 | 278.84 | 46.5 | Cancer statistics, 2009. | Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J Thun | CA Cancer J Clin | 2009 | 19474385 | Yes |
| 1800 | 1458 | 1458.0 | 0.0 | 0.0 | The organization of proteins in the human red blood cell membrane. A review. | T L Steck | J Cell Biol | 1974 | 4600883 | No |
| 1801 | 2916 | 1458.0 | 60.95 | 30.5 | The Bcl2 family: regulators of the cellular life-or-death switch. | Suzanne Cory, Jerry M Adams | Nat Rev Cancer | 2002 | 12209154 | No |
| 1802 | 1458 | 1458.0 | 0.0 | 0.0 | Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. | I E Bush | Biochem J | 1952 | 14915960 | Yes |
| 1803 | 1457 | 1457.0 | 30.49 | 30.5 | Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. | R K Jain | Nat Med | 2001 | 11533692 | No |
| 1804 | 1457 | 1457.0 | 33.43 | 33.4 | The NCI60 human tumour cell line anticancer drug screen. | Robert H Shoemaker | Nat Rev Cancer | 2006 | 16990858 | No |
| 1805 | 2913 | 1456.5 | 76.0 | 38.0 | Empirical threshold values for quantitative trait mapping. | G A Churchill, R W Doerge | Genetics | 1994 | 7851788 | Yes |
| 1806 | 2912 | 1456.0 | 76.7 | 38.4 | The expanding universe of T-cell subsets: Th1, Th2 and more. | T R Mosmann, S Sad | Immunol Today | 1996 | 8820272 | No |
| 1807 | 2912 | 1456.0 | 79.56 | 39.8 | Early identification of refractory epilepsy. | P Kwan, M J Brodie | N Engl J Med | 2000 | 10660394 | Yes |
| 1808 | 2912 | 1456.0 | 81.23 | 40.6 | Dali server: conservation mapping in 3D. | Liisa Holm, Päivi Rosenström | Nucleic Acids Res | 2010 | 20457744 | Yes |
| 1809 | 1455 | 1455.0 | 0.0 | 0.0 | Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. | P C Nowell | Cancer Res | 1960 | 14427849 | Yes |
| 1810 | 1454 | 1454.0 | 46.77 | 46.8 | The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. | G R Buettner | Arch Biochem Biophys | 1993 | 8434935 | No |
| 1811 | 2908 | 1454.0 | 55.94 | 28.0 | Cellular motility driven by assembly and disassembly of actin filaments. | Thomas D Pollard, Gary G Borisy | Cell | 2003 | 12600310 | No |
| 1812 | 2906 | 1453.0 | 103.16 | 51.6 | Saliency, switching, attention and control: a network model of insula function. | Vinod Menon, Lucina Q Uddin | Brain Struct Funct | 2010 | 20512370 | No |
| 1813 | 2904 | 1452.0 | 0.0 | 0.0 | Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. | D H Clarke, J Casals | Am J Trop Med Hyg | 1958 | 13571577 | Yes |
| 1814 | 1452 | 1452.0 | 0.0 | 0.0 | The free amino groups of insulin. | F Sanger | Biochem J | 1945 | 16747948 | Yes |
| 1815 | 2903 | 1451.5 | 68.34 | 34.2 | Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. | C Auffray, F Rougeon | Eur J Biochem | 1980 | 6772444 | Yes |
| 1816 | 1451 | 1451.0 | 33.93 | 33.9 | Pathogenesis of group A streptococcal infections. | M W Cunningham | Clin Microbiol Rev | 2000 | 10885988 | No |
| 1817 | 1450 | 1450.0 | 43.08 | 43.1 | Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. | M D Maines | FASEB J | 1988 | 3290025 | No |
| 1818 | 1449 | 1449.0 | 0.0 | 0.0 | Superoxide dismutases. | I Fridovich | Annu Rev Biochem | 1975 | 1094908 | No |
| 1819 | 1449 | 1449.0 | 60.43 | 60.4 | Responses to depression and their effects on the duration of depressive episodes. | S Nolen-Hoeksema | J Abnorm Psychol | 1991 | 1757671 | No |
| 1820 | 1449 | 1449.0 | 0.0 | 0.0 | Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. | J W Olney | Science | 1969 | 5778021 | Yes |
| 1821 | 1449 | 1449.0 | 45.07 | 45.1 | Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. | L Bravo | Nutr Rev | 1998 | 9838798 | No |
| 1822 | 1449 | 1449.0 | 0.0 | 0.0 | Starch gel electrophoresis in a discontinous system of buffers. | M D Poulik | Nature | 1957 | 13493570 | Yes |
| 1823 | 8691 | 1448.5 | 286.84 | 47.8 | New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. | Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier Gascuel | Syst Biol | 2010 | 20525638 | Yes |
| 1824 | 1448 | 1448.0 | 48.74 | 48.7 | Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. | G A McPherson | J Pharmacol Methods | 1985 | 3840547 | Yes |
| 1825 | 4343 | 1447.7 | 147.08 | 49.0 | Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. | Helga Thorvaldsdóttir, James T Robinson, Jill P Mesirov | Brief Bioinform | 2013 | 22517427 | Yes |
| 1826 | 2894 | 1447.0 | 80.47 | 40.2 | A rapid boiling method for the preparation of bacterial plasmids. | D S Holmes, M Quigley | Anal Biochem | 1981 | 6269464 | Yes |
| 1827 | 2894 | 1447.0 | 108.22 | 54.1 | The need to belong: desire for interpersonal attachments as a fundamental human motivation. | R F Baumeister, M R Leary | Psychol Bull | 1995 | 7777651 | No |
| 1828 | 5787 | 1446.8 | 173.58 | 43.4 | The validity of the Hospital Anxiety and Depression Scale. An updated literature review. | Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag Neckelmann | J Psychosom Res | 2002 | 11832252 | No |
| 1829 | 5786 | 1446.5 | 0.0 | 0.0 | The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. | L A Sternberger, P H Hardy, J J Cuculis, H G Meyer | J Histochem Cytochem | 1970 | 4192899 | Yes |
| 1830 | 5786 | 1446.5 | 244.07 | 61.0 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | Int J Surg | 2010 | 20171303 | No |
| 1831 | 1446 | 1446.0 | 44.33 | 44.3 | Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. | James J P Stewart | J Mol Model | 2007 | 17828561 | Yes |
| 1832 | 1445 | 1445.0 | 0.0 | 0.0 | The genetical evolution of social behaviour. II. | W D Hamilton | J Theor Biol | 1964 | 5875340 | Yes |
| 1833 | 1444 | 1444.0 | 45.74 | 45.7 | Polycystic ovary syndrome. | S Franks | N Engl J Med | 1995 | 7651477 | No |
| 1834 | 2888 | 1444.0 | 94.75 | 47.4 | Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. | G R Gibson, M B Roberfroid | J Nutr | 1995 | 7782892 | No |
| 1835 | 1444 | 1444.0 | 60.63 | 60.6 | Adverse health effects of high-effort/low-reward conditions. | J Siegrist | J Occup Health Psychol | 1996 | 9547031 | No |
| 1836 | 2886 | 1443.0 | 0.0 | 0.0 | Assay of proteins in the presence of interfering materials. | A Bensadoun, D Weinstein | Anal Biochem | 1976 | 1259145 | Yes |
| 1837 | 1443 | 1443.0 | 34.41 | 34.4 | Binary Agrobacterium vectors for plant transformation. | M Bevan | Nucleic Acids Res | 1984 | 6095209 | Yes |
| 1838 | 2886 | 1443.0 | 103.05 | 51.5 | The Oswestry Disability Index. | J C Fairbank, P B Pynsent | Spine (Phila Pa 1976) | 2000 | 11074683 | No |
| 1839 | 2885 | 1442.5 | 67.54 | 33.8 | A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. | L Buck, R Axel | Cell | 1991 | 1840504 | Yes |
| 1840 | 12978 | 1442.0 | 405.38 | 45.0 | The 1982 revised criteria for the classification of systemic lupus erythematosus. | E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J Winchester | Arthritis Rheum | 1982 | 7138600 | Yes |
| 1841 | 1442 | 1442.0 | 0.0 | 0.0 | Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. | H E Huxley | J Mol Biol | 1963 | 14064165 | Yes |
| 1842 | 1442 | 1442.0 | 43.35 | 43.4 | Semiempirical hybrid density functional with perturbative second-order correlation. | Stefan Grimme | J Chem Phys | 2006 | 16438568 | Yes |
| 1843 | 1441 | 1441.0 | 0.0 | 0.0 | Stability of proteins: small globular proteins. | P L Privalov | Adv Protein Chem | 1979 | 44431 | No |
| 1844 | 2882 | 1441.0 | 0.0 | 0.0 | 3' non-coding region sequences in eukaryotic messenger RNA. | N J Proudfoot, G G Brownlee | Nature | 1976 | 822353 | Yes |
| 1845 | 2882 | 1441.0 | 79.32 | 39.7 | Angiogenesis. | J Folkman, Y Shing | J Biol Chem | 1992 | 1375931 | No |
| 1846 | 1441 | 1441.0 | 25.88 | 25.9 | Histone acetylation and transcriptional regulatory mechanisms. | K Struhl | Genes Dev | 1998 | 9499396 | No |
| 1847 | 2882 | 1441.0 | 0.0 | 0.0 | Mutants of Escherichia coli requiring methionine or vitamin B12. | B D Davis, E S Mingioli | J Bacteriol | 1950 | 15436457 | Yes |
| 1848 | 1441 | 1441.0 | 36.64 | 36.6 | The failing heart--an engine out of fuel. | Stefan Neubauer | N Engl J Med | 2007 | 17360992 | No |
| 1849 | 2881 | 1440.5 | 59.86 | 29.9 | Chemokines: a new classification system and their role in immunity. | A Zlotnik, O Yoshie | Immunity | 2000 | 10714678 | No |
| 1850 | 7197 | 1439.4 | 149.77 | 30.0 | Prospective identification of tumorigenic breast cancer cells. | Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F Clarke | Proc Natl Acad Sci U S A | 2003 | 12629218 | Yes |
| 1851 | 1439 | 1439.0 | 37.66 | 37.7 | Capacitative calcium entry revisited. | J W Putney | Cell Calcium | 1990 | 1965707 | No |
| 1852 | 1439 | 1439.0 | 50.91 | 50.9 | Matching methods for causal inference: A review and a look forward. | Elizabeth A Stuart | Stat Sci | 2010 | 20871802 | Yes |
| 1853 | 1438 | 1438.0 | 35.24 | 35.2 | The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. | H Maeda | Adv Enzyme Regul | 2001 | 11384745 | No |
| 1854 | 4312 | 1437.3 | 0.0 | 0.0 | Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. | C A Winter, E A Risley, G W Nuss | Proc Soc Exp Biol Med | 1962 | 14001233 | Yes |
| 1855 | 1436 | 1436.0 | 27.45 | 27.4 | Aggresomes, inclusion bodies and protein aggregation. | R R Kopito | Trends Cell Biol | 2000 | 11121744 | No |
| 1856 | 1436 | 1436.0 | 41.54 | 41.5 | Glycobiology: Toward Understanding the Function of Sugars. | Raymond A. Dwek | Chem Rev | 1996 | 11848770 | Yes |
| 1857 | 1435 | 1435.0 | 34.05 | 34.0 | PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. | B M Spiegelman | Diabetes | 1998 | 9568680 | No |
| 1858 | 1435 | 1435.0 | 0.0 | 0.0 | Modality and topographic properties of single neurons of cat's somatic sensory cortex. | V B Mountcastle | J Neurophysiol | 1957 | 13439410 | Yes |
| 1859 | 1435 | 1435.0 | 0.0 | 0.0 | Note on the sampling error of the difference between correlated proportions or percentages. | Q McNEMAR | Psychometrika | 1947 | 20254758 | Yes |
| 1860 | 1434 | 1434.0 | 33.77 | 33.8 | Developmental cell death: morphological diversity and multiple mechanisms. | P G Clarke | Anat Embryol (Berl) | 1990 | 2186664 | No |
| 1861 | 1434 | 1434.0 | 49.8 | 49.8 | The polyvagal perspective. | Stephen W Porges | Biol Psychol | 2007 | 17049418 | No |
| 1862 | 2864 | 1432.0 | 83.84 | 41.9 | Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. | Sally S Dickerson, Margaret E Kemeny | Psychol Bull | 2004 | 15122924 | Yes |
| 1863 | 2864 | 1432.0 | 73.5 | 36.8 | Malignant gliomas in adults. | Patrick Y Wen, Santosh Kesari | N Engl J Med | 2008 | 18669428 | No |
| 1864 | 1431 | 1431.0 | 27.51 | 27.5 | Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. | M G Gustafsson | J Microsc | 2000 | 10810003 | Yes |
| 1865 | 1431 | 1431.0 | 0.0 | 0.0 | A modified ninhydrin colorimetric analysis for amino acids. | H Rosen | Arch Biochem Biophys | 1957 | 13412116 | Yes |
| 1866 | 1431 | 1431.0 | 41.33 | 41.3 | n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. | Philip C Calder | Am J Clin Nutr | 2006 | 16841861 | No |
| 1867 | 1430 | 1430.0 | 37.56 | 37.6 | Aspergillus fumigatus and aspergillosis. | J P Latgé | Clin Microbiol Rev | 1999 | 10194462 | No |
| 1868 | 1430 | 1430.0 | 44.02 | 44.0 | The many roles for fluorine in medicinal chemistry. | William K Hagmann | J Med Chem | 2008 | 18570365 | Yes |
| 1869 | 2859 | 1429.5 | 64.91 | 32.5 | Microtubules as a target for anticancer drugs. | Mary Ann Jordan, Leslie Wilson | Nat Rev Cancer | 2004 | 15057285 | No |
| 1870 | 1429 | 1429.0 | 0.0 | 0.0 | The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. | O V Batson | Ann Surg | 1940 | 17857618 | Yes |
| 1871 | 2857 | 1428.5 | 72.05 | 36.0 | Steatohepatitis: a tale of two "hits"? | C P Day, O F James | Gastroenterology | 1998 | 9547102 | No |
| 1872 | 2857 | 1428.5 | 65.64 | 32.8 | How matrix metalloproteinases regulate cell behavior. | M D Sternlicht, Z Werb | Annu Rev Cell Dev Biol | 2001 | 11687497 | No |
| 1873 | 1428 | 1428.0 | 0.0 | 0.0 | A clinical method for assessing the ventilatory response to carbon dioxide. | D J Read | Australas Ann Med | 1967 | 6032026 | Yes |
| 1874 | 1428 | 1428.0 | 35.41 | 35.4 | Five rules for the evolution of cooperation. | Martin A Nowak | Science | 2006 | 17158317 | No |
| 1875 | 2853 | 1426.5 | 0.0 | 0.0 | The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. | J O'Keefe, J Dostrovsky | Brain Res | 1971 | 5124915 | Yes |
| 1876 | 1425 | 1425.0 | 35.53 | 35.5 | General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. | R A Houghten | Proc Natl Acad Sci U S A | 1985 | 2410914 | Yes |
| 1877 | 2849 | 1424.5 | 0.0 | 0.0 | A scaled version of the General Health Questionnaire. | D P Goldberg, V F Hillier | Psychol Med | 1979 | 424481 | Yes |
| 1878 | 2849 | 1424.5 | 90.61 | 45.3 | Density functionals with broad applicability in chemistry. | Yan Zhao, Donald G Truhlar | Acc Chem Res | 2008 | 18186612 | Yes |
| 1879 | 1424 | 1424.0 | 0.0 | 0.0 | Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. | M P Blaustein | Am J Physiol | 1977 | 324293 | No |
| 1880 | 2848 | 1424.0 | 118.0 | 59.0 | Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. | A Y Finlay, G K Khan | Clin Exp Dermatol | 1994 | 8033378 | Yes |
| 1881 | 2847 | 1423.5 | 59.88 | 29.9 | Fitting a mixture model by expectation maximization to discover motifs in biopolymers. | T L Bailey, C Elkan | Proc Int Conf Intell Syst Mol Biol | 1994 | 7584402 | Yes |
| 1882 | 2845 | 1422.5 | 64.03 | 32.0 | Neurotrophins: roles in neuronal development and function. | E J Huang, L F Reichardt | Annu Rev Neurosci | 2001 | 11520916 | No |
| 1883 | 1422 | 1422.0 | 29.6 | 29.6 | RNA silencing in plants. | David Baulcombe | Nature | 2004 | 15372043 | No |
| 1884 | 1421 | 1421.0 | 35.72 | 35.7 | Myeloperoxidase: friend and foe. | Seymour J Klebanoff | J Leukoc Biol | 2005 | 15689384 | No |
| 1885 | 1421 | 1421.0 | 33.19 | 33.2 | Far-field optical nanoscopy. | Stefan W Hell | Science | 2007 | 17525330 | No |
| 1886 | 2841 | 1420.5 | 60.4 | 30.2 | Development by self-digestion: molecular mechanisms and biological functions of autophagy. | Beth Levine, Daniel J Klionsky | Dev Cell | 2004 | 15068787 | No |
| 1887 | 1420 | 1420.0 | 32.26 | 32.3 | Tumor metastasis: mechanistic insights and clinical challenges. | Patricia S Steeg | Nat Med | 2006 | 16892035 | No |
| 1888 | 4260 | 1420.0 | 112.09 | 37.4 | Optimization by simulated annealing. | S Kirkpatrick, C D Gelatt, M P Vecchi | Science | 1983 | 17813860 | Yes |
| 1889 | 1419 | 1419.0 | 53.54 | 53.5 | UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. | D W Russell | J Pers Assess | 1996 | 8576833 | Yes |
| 1890 | 2838 | 1419.0 | 68.82 | 34.4 | Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. | F Q Schafer, G R Buettner | Free Radic Biol Med | 2001 | 11368918 | No |
| 1891 | 1419 | 1419.0 | 38.72 | 38.7 | Task switching. | Stephen Monsell | Trends Cogn Sci | 2003 | 12639695 | Yes |
| 1892 | 1419 | 1419.0 | 27.6 | 27.6 | Vienna RNA secondary structure server. | Ivo L Hofacker | Nucleic Acids Res | 2003 | 12824340 | Yes |
| 1893 | 2838 | 1419.0 | 76.01 | 38.0 | Macrophage diversity enhances tumor progression and metastasis. | Bin-Zhi Qian, Jeffrey W Pollard | Cell | 2010 | 20371344 | No |
| 1894 | 4256 | 1418.7 | 105.52 | 35.2 | Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. | Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck Ørntoft | Cancer Res | 2004 | 15289330 | Yes |
| 1895 | 1418 | 1418.0 | 0.0 | 0.0 | Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. | C A Barnes | J Comp Physiol Psychol | 1979 | 221551 | Yes |
| 1896 | 1418 | 1418.0 | 72.76 | 72.8 | Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. | F E Zajac | Crit Rev Biomed Eng | 1989 | 2676342 | No |
| 1897 | 1418 | 1418.0 | 34.36 | 34.4 | Two pathogenetic types of endometrial carcinoma. | J V Bokhman | Gynecol Oncol | 1983 | 6822361 | Yes |
| 1898 | 1418 | 1418.0 | 46.07 | 46.1 | Efficient analysis of experimental observations. | W J Dixon | Annu Rev Pharmacol Toxicol | 1980 | 7387124 | Yes |
| 1899 | 2835 | 1417.5 | 65.58 | 32.8 | Lipopolysaccharide endotoxins. | Christian R H Raetz, Chris Whitfield | Annu Rev Biochem | 2002 | 12045108 | No |
| 1900 | 4251 | 1417.0 | 93.32 | 31.1 | NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. | S Ghosh, M J May, E B Kopp | Annu Rev Immunol | 1998 | 9597130 | No |
| 1901 | 2834 | 1417.0 | 60.62 | 30.3 | Coordination of circadian timing in mammals. | Steven M Reppert, David R Weaver | Nature | 2002 | 12198538 | No |
| 1902 | 1417 | 1417.0 | 32.67 | 32.7 | Hematopoietic stem-cell transplantation. | Edward A Copelan | N Engl J Med | 2006 | 16641398 | No |
| 1903 | 7083 | 1416.6 | 302.51 | 60.5 | UCHIME improves sensitivity and speed of chimera detection. | Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob Knight | Bioinformatics | 2011 | 21700674 | Yes |
| 1904 | 2833 | 1416.5 | 66.49 | 33.2 | The MAPK signaling cascade. | R Seger, E G Krebs | FASEB J | 1995 | 7601337 | No |
| 1905 | 1415 | 1415.0 | 32.93 | 32.9 | The molecular logic of endocannabinoid signalling. | Daniele Piomelli | Nat Rev Neurosci | 2003 | 14595399 | No |
| 1906 | 4244 | 1414.7 | 122.14 | 40.7 | The fusiform face area: a module in human extrastriate cortex specialized for face perception. | N Kanwisher, J McDermott, M M Chun | J Neurosci | 1997 | 9151747 | Yes |
| 1907 | 2828 | 1414.0 | 73.81 | 36.9 | Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. | I Issemann, S Green | Nature | 1990 | 2129546 | Yes |
| 1908 | 1413 | 1413.0 | 57.7 | 57.7 | A structured interview guide for the Hamilton Depression Rating Scale. | J B Williams | Arch Gen Psychiatry | 1988 | 3395203 | Yes |
| 1909 | 1413 | 1413.0 | 0.0 | 0.0 | R factor transfer in Rhizobium leguminosarum. | J E Beringer | J Gen Microbiol | 1974 | 4612098 | Yes |
| 1910 | 1413 | 1413.0 | 0.0 | 0.0 | The measurement of psychological androgyny. | S L Bem | J Consult Clin Psychol | 1974 | 4823550 | Yes |
| 1911 | 1412 | 1412.0 | 38.15 | 38.1 | A more meaningful scoring system for determining the severity of coronary heart disease. | G G Gensini | Am J Cardiol | 1983 | 6823874 | Yes |
| 1912 | 2820 | 1410.0 | 0.0 | 0.0 | Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. | H J Bloom, W W Richardson | Br J Cancer | 1957 | 13499785 | Yes |
| 1913 | 2820 | 1410.0 | 64.06 | 32.0 | Cancer metastasis: building a framework. | Gaorav P Gupta, Joan Massagué | Cell | 2006 | 17110329 | No |
| 1914 | 2819 | 1409.5 | 85.35 | 42.7 | The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. | J D Hayes, D J Pulford | Crit Rev Biochem Mol Biol | 1995 | 8770536 | No |
| 1915 | 2816 | 1408.0 | 63.58 | 31.8 | Raster3D Version 2.0. A program for photorealistic molecular graphics. | E A Merritt, M E Murphy | Acta Crystallogr D Biol Crystallogr | 1994 | 15299354 | Yes |
| 1916 | 1407 | 1407.0 | 0.0 | 0.0 | Microbial ecology of the gastrointestinal tract. | D C Savage | Annu Rev Microbiol | 1977 | 334036 | No |
| 1917 | 1406 | 1406.0 | 31.77 | 31.8 | Cancer epigenomics: DNA methylomes and histone-modification maps. | Manel Esteller | Nat Rev Genet | 2007 | 17339880 | No |
| 1918 | 1406 | 1406.0 | 42.56 | 42.6 | Surface plasmon resonance sensors for detection of chemical and biological species. | Jirí Homola | Chem Rev | 2008 | 18229953 | No |
| 1919 | 2811 | 1405.5 | 89.61 | 44.8 | Functional architecture of basal ganglia circuits: neural substrates of parallel processing. | G E Alexander, M D Crutcher | Trends Neurosci | 1990 | 1695401 | No |
| 1920 | 1405 | 1405.0 | 31.33 | 31.3 | Protein misfolding, evolution and disease. | C M Dobson | Trends Biochem Sci | 1999 | 10470028 | No |
| 1921 | 1404 | 1404.0 | 0.0 | 0.0 | Human cardiovascular adjustments to exercise and thermal stress. | L B Rowell | Physiol Rev | 1974 | 4587247 | No |
| 1922 | 1403 | 1403.0 | 0.0 | 0.0 | Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. | J Wyman | Adv Protein Chem | 1964 | 14268785 | No |
| 1923 | 2806 | 1403.0 | 0.0 | 0.0 | Mutations of Bacteria from Virus Sensitivity to Virus Resistance. | S E Luria, M Delbrück | Genetics | 1943 | 17247100 | Yes |
| 1924 | 1403 | 1403.0 | 45.91 | 45.9 | Stress signalling pathways that impair prefrontal cortex structure and function. | Amy F T Arnsten | Nat Rev Neurosci | 2009 | 19455173 | No |
| 1925 | 7010 | 1402.0 | 152.5 | 30.5 | Site-directed mutagenesis by overlap extension using the polymerase chain reaction. | S N Ho, H D Hunt, R M Horton, J K Pullen, L R Pease | Gene | 1989 | 2744487 | Yes |
| 1926 | 1402 | 1402.0 | 32.53 | 32.5 | Ordered porous materials for emerging applications. | Mark E Davis | Nature | 2002 | 12075343 | No |
| 1927 | 1402 | 1402.0 | 0.0 | 0.0 | Cerebral vascular accidents in patients over the age of 60. II. Prognosis. | J Rankin | Scott Med J | 1957 | 13432835 | Yes |
| 1928 | 2804 | 1402.0 | 0.0 | 0.0 | The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. | E G Gray, V P Whittaker | J Anat | 1962 | 13901297 | Yes |
| 1929 | 2803 | 1401.5 | 112.34 | 56.2 | Assessment of eating disorders: interview or self-report questionnaire? | C G Fairburn, S J Beglin | Int J Eat Disord | 1994 | 7866415 | Yes |
| 1930 | 2802 | 1401.0 | 86.11 | 43.1 | Intracellular pH. | A Roos, W F Boron | Physiol Rev | 1981 | 7012859 | No |
| 1931 | 2802 | 1401.0 | 0.0 | 0.0 | Microdetermination of long-chain fatty acids in plasma and tissues. | V P Dole, H Meinertz | J Biol Chem | 1960 | 13817286 | Yes |
| 1932 | 2801 | 1400.5 | 93.18 | 46.6 | The efficiency of systematic sampling in stereology and its prediction. | H J Gundersen, E B Jensen | J Microsc | 1987 | 3430576 | Yes |
| 1933 | 2800 | 1400.0 | 0.0 | 0.0 | Empirical predictions of protein conformation. | P Y Chou, G D Fasman | Annu Rev Biochem | 1978 | 354496 | No |
| 1934 | 1400 | 1400.0 | 36.93 | 36.9 | Use and misuse of the receiver operating characteristic curve in risk prediction. | Nancy R Cook | Circulation | 2007 | 17309939 | Yes |
| 1935 | 2798 | 1399.0 | 85.69 | 42.8 | Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. | P J Basser, C Pierpaoli | J Magn Reson B | 1996 | 8661285 | Yes |
| 1936 | 2798 | 1399.0 | 55.8 | 27.9 | The evolutionary fate and consequences of duplicate genes. | M Lynch, J S Conery | Science | 2000 | 11073452 | No |
| 1937 | 2798 | 1399.0 | 73.66 | 36.8 | Obesity. | David W Haslam, W Philip T James | Lancet | 2005 | 16198769 | No |
| 1938 | 2797 | 1398.5 | 0.0 | 0.0 | Brain stem reticular formation and activation of the EEG. | G Moruzzi, H W Magoun | Electroencephalogr Clin Neurophysiol | 1949 | 18421835 | Yes |
| 1939 | 1398 | 1398.0 | 0.0 | 0.0 | Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. | K S McCully | Am J Pathol | 1969 | 5792556 | Yes |
| 1940 | 5590 | 1397.5 | 126.31 | 31.6 | Probability-based protein identification by searching sequence databases using mass spectrometry data. | D N Perkins, D J Pappin, D M Creasy, J S Cottrell | Electrophoresis | 1999 | 10612281 | Yes |
| 1941 | 1397 | 1397.0 | 35.74 | 35.7 | An economic method for the fluorescent labeling of PCR fragments. | M Schuelke | Nat Biotechnol | 2000 | 10657137 | Yes |
| 1942 | 1397 | 1397.0 | 36.84 | 36.8 | Hydrogels for biomedical applications. | Allan S Hoffman | Adv Drug Deliv Rev | 2002 | 11755703 | No |
| 1943 | 1396 | 1396.0 | 57.7 | 57.7 | Sample size in qualitative research. | M Sandelowski | Res Nurs Health | 1995 | 7899572 | Yes |
| 1944 | 1396 | 1396.0 | 33.13 | 33.1 | Functions of ceramide in coordinating cellular responses to stress. | Y A Hannun | Science | 1996 | 8943189 | No |
| 1945 | 1395 | 1395.0 | 32.95 | 33.0 | Speculations on the functions of the major heat shock and glucose-regulated proteins. | H R Pelham | Cell | 1986 | 2944601 | Yes |
| 1946 | 9763 | 1394.7 | 216.09 | 30.9 | Embryonic stem cell lines derived from human blastocysts. | J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M Jones | Science | 1998 | 9804556 | Yes |
| 1947 | 1394 | 1394.0 | 40.5 | 40.5 | Isolation and cultivation of Lyme disease spirochetes. | A G Barbour | Yale J Biol Med | 1984 | 6393604 | Yes |
| 1948 | 2788 | 1394.0 | 63.97 | 32.0 | NF-kappaB: a key role in inflammatory diseases. | P P Tak, G S Firestein | J Clin Invest | 2001 | 11134171 | No |
| 1949 | 1394 | 1394.0 | 39.24 | 39.2 | A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. | J Engel | Epilepsia | 2001 | 11422340 | Yes |
| 1950 | 1394 | 1394.0 | 29.59 | 29.6 | The Buccaneer software for automated model building. 1. Tracing protein chains. | Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2006 | 16929101 | Yes |
| 1951 | 4181 | 1393.7 | 142.3 | 47.4 | Vascular endothelial cells synthesize nitric oxide from L-arginine. | R M Palmer, D S Ashton, S Moncada | Nature | 1988 | 3131684 | Yes |
| 1952 | 1393 | 1393.0 | 32.07 | 32.1 | The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. | M Takeichi | Development | 1988 | 3048970 | No |
| 1953 | 1393 | 1393.0 | 0.0 | 0.0 | Codon--anticodon pairing: the wobble hypothesis. | F H Crick | J Mol Biol | 1966 | 5969078 | Yes |
| 1954 | 1393 | 1393.0 | 30.23 | 30.2 | Neurotrophins as synaptic modulators. | M M Poo | Nat Rev Neurosci | 2001 | 11253356 | No |
| 1955 | 1392 | 1392.0 | 39.89 | 39.9 | Leishmaniasis: current situation and new perspectives. | P Desjeux | Comp Immunol Microbiol Infect Dis | 2004 | 15225981 | No |
| 1956 | 1391 | 1391.0 | 37.47 | 37.5 | Cell and environment interactions in tumor microregions: the multicell spheroid model. | R M Sutherland | Science | 1988 | 2451290 | Yes |
| 1957 | 1391 | 1391.0 | 34.07 | 34.1 | Neuronal synchrony: a versatile code for the definition of relations? | W Singer | Neuron | 1999 | 10677026 | No |
| 1958 | 1391 | 1391.0 | 0.0 | 0.0 | Potential, Impedance, And Rectification In Membranes. | D E Goldman | J Gen Physiol | 1943 | 19873371 | Yes |
| 1959 | 2779 | 1389.5 | 93.19 | 46.6 | The pathogenesis of rheumatoid arthritis. | Iain B McInnes, Georg Schett | N Engl J Med | 2011 | 22150039 | No |
| 1960 | 1389 | 1389.0 | 26.5 | 26.5 | Ubiquitin-dependent protein degradation. | M Hochstrasser | Annu Rev Genet | 1996 | 8982460 | No |
| 1961 | 1389 | 1389.0 | 0.0 | 0.0 | Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. | W C Schneider | J Biol Chem | 1948 | 18886166 | Yes |
| 1962 | 2777 | 1388.5 | 71.16 | 35.6 | CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. | D G Higgins, P M Sharp | Gene | 1988 | 3243435 | Yes |
| 1963 | 2776 | 1388.0 | 0.0 | 0.0 | A method of trace iodination of proteins for immunologic studies. | P J McConahey, F J Dixon | Int Arch Allergy Appl Immunol | 1966 | 4160044 | Yes |
| 1964 | 2776 | 1388.0 | 62.15 | 31.1 | An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. | A A Beg, D Baltimore | Science | 1996 | 8864118 | Yes |
| 1965 | 2775 | 1387.5 | 169.92 | 85.0 | Rating systems in the evaluation of knee ligament injuries. | Y Tegner, J Lysholm | Clin Orthop Relat Res | 1985 | 4028566 | Yes |
| 1966 | 2775 | 1387.5 | 85.04 | 42.5 | Protective and pathogenic functions of macrophage subsets. | Peter J Murray, Thomas A Wynn | Nat Rev Immunol | 2011 | 21997792 | No |
| 1967 | 1387 | 1387.0 | 92.73 | 92.7 | The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. | F C Ewald | Clin Orthop Relat Res | 1989 | 2805502 | Yes |
| 1968 | 1387 | 1387.0 | 0.0 | 0.0 | Selection of successive tumour lines for metastasis. | I J Fidler | Nat New Biol | 1973 | 4512654 | Yes |
| 1969 | 1387 | 1387.0 | 29.33 | 29.3 | Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. | S S Ferguson | Pharmacol Rev | 2001 | 11171937 | No |
| 1970 | 1386 | 1386.0 | 35.59 | 35.6 | Stress and hippocampal plasticity. | B S McEwen | Annu Rev Neurosci | 1999 | 10202533 | No |
| 1971 | 1386 | 1386.0 | 49.13 | 49.1 | The global impact of pre-eclampsia and eclampsia. | Lelia Duley | Semin Perinatol | 2009 | 19464502 | No |
| 1972 | 2771 | 1385.5 | 62.39 | 31.2 | Self-assembly at all scales. | George M Whitesides, Bartosz Grzybowski | Science | 2002 | 11923529 | Yes |
| 1973 | 2770 | 1385.0 | 72.05 | 36.0 | A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. | J Messing, J Vieira | Gene | 1982 | 6295880 | Yes |
| 1974 | 2769 | 1384.5 | 70.25 | 35.1 | Unravelling the pathogenesis of inflammatory bowel disease. | R J Xavier, D K Podolsky | Nature | 2007 | 17653185 | No |
| 1975 | 4151 | 1383.7 | 97.86 | 32.6 | Click Chemistry: Diverse Chemical Function from a Few Good Reactions. | Hartmuth C. Kolb, M. G. Finn, K. Barry Sharpless | Angew Chem Int Ed Engl | 2001 | 11433435 | Yes |
| 1976 | 2767 | 1383.5 | 77.57 | 38.8 | Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. | B R Celli, W MacNee | Eur Respir J | 2004 | 15219010 | No |
| 1977 | 2767 | 1383.5 | 80.11 | 40.1 | Molecular mechanisms of long noncoding RNAs. | Kevin C Wang, Howard Y Chang | Mol Cell | 2011 | 21925379 | No |
| 1978 | 2766 | 1383.0 | 0.0 | 0.0 | Prediction of protein conformation. | P Y Chou, G D Fasman | Biochemistry | 1974 | 4358940 | Yes |
| 1979 | 4148 | 1382.7 | 92.19 | 30.7 | Telomeres shorten during ageing of human fibroblasts. | C B Harley, A B Futcher, C W Greider | Nature | 1990 | 2342578 | Yes |
| 1980 | 2765 | 1382.5 | 58.53 | 29.3 | A guided tour into subcellular colocalization analysis in light microscopy. | S Bolte, F P Cordelières | J Microsc | 2006 | 17210054 | Yes |
| 1981 | 2765 | 1382.5 | 85.18 | 42.6 | A perspective on cancer cell metastasis. | Christine L Chaffer, Robert A Weinberg | Science | 2011 | 21436443 | No |
| 1982 | 1382 | 1382.0 | 44.16 | 44.2 | Equipoise and the ethics of clinical research. | B Freedman | N Engl J Med | 1987 | 3600702 | Yes |
| 1983 | 1382 | 1382.0 | 33.5 | 33.5 | The basic science of gene therapy. | R C Mulligan | Science | 1993 | 8493530 | No |
| 1984 | 1382 | 1382.0 | 33.09 | 33.1 | Neurotrophin-regulated signalling pathways. | Louis F Reichardt | Philos Trans R Soc Lond B Biol Sci | 2006 | 16939974 | No |
| 1985 | 1381 | 1381.0 | 28.16 | 28.2 | Macromolecular crowding: obvious but underappreciated. | R J Ellis | Trends Biochem Sci | 2001 | 11590012 | No |
| 1986 | 4143 | 1381.0 | 91.98 | 30.7 | TOR signaling in growth and metabolism. | Stephan Wullschleger, Robbie Loewith, Michael N Hall | Cell | 2006 | 16469695 | No |
| 1987 | 5521 | 1380.2 | 146.2 | 36.5 | Most mammalian mRNAs are conserved targets of microRNAs. | Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel | Genome Res | 2009 | 18955434 | Yes |
| 1988 | 1380 | 1380.0 | 54.61 | 54.6 | Cardiac valve surgery--the "French correction". | A Carpentier | J Thorac Cardiovasc Surg | 1983 | 6887954 | Yes |
| 1989 | 1380 | 1380.0 | 26.47 | 26.5 | NK cell receptors. | L L Lanier | Annu Rev Immunol | 1998 | 9597134 | No |
| 1990 | 2759 | 1379.5 | 0.0 | 0.0 | The effect of sodium ions on the electrical activity of giant axon of the squid. | A L Hodgkin, B Katz | J Physiol | 1949 | 18128147 | Yes |
| 1991 | 1379 | 1379.0 | 31.9 | 31.9 | Protein kinase C: structure, function, and regulation. | A C Newton | J Biol Chem | 1995 | 7499357 | No |
| 1992 | 1379 | 1379.0 | 51.0 | 51.0 | Functional and effective connectivity: a review. | Karl J Friston | Brain Connect | 2011 | 22432952 | No |
| 1993 | 2754 | 1377.0 | 53.64 | 26.8 | T-cell antigen receptor genes and T-cell recognition. | M M Davis, P J Bjorkman | Nature | 1988 | 3043226 | No |
| 1994 | 1377 | 1377.0 | 40.87 | 40.9 | The aging process. | D Harman | Proc Natl Acad Sci U S A | 1981 | 6947277 | Yes |
| 1995 | 2754 | 1377.0 | 76.72 | 38.4 | Transforming growth factor beta in tissue fibrosis. | W A Border, N A Noble | N Engl J Med | 1994 | 7935686 | No |
| 1996 | 1377 | 1377.0 | 36.56 | 36.6 | The importance of the ratio of omega-6/omega-3 essential fatty acids. | A P Simopoulos | Biomed Pharmacother | 2002 | 12442909 | No |
| 1997 | 1376 | 1376.0 | 0.0 | 0.0 | Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. | S S Lehrer | Biochemistry | 1971 | 5119250 | Yes |
| 1998 | 4128 | 1376.0 | 88.66 | 29.6 | Toll-like receptors. | Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira | Annu Rev Immunol | 2003 | 12524386 | No |
| 1999 | 2752 | 1376.0 | 85.4 | 42.7 | Astrocytes: biology and pathology. | Michael V Sofroniew, Harry V Vinters | Acta Neuropathol | 2010 | 20012068 | No |
| 2000 | 1375 | 1375.0 | 33.64 | 33.6 | Oxidative stress in Parkinson's disease. | Peter Jenner | Ann Neurol | 2003 | 12666096 | No |
| 2001 | 2748 | 1374.0 | 0.0 | 0.0 | Immunoassay of endogenous plasma insulin in man. | R S Yalow, S A Berson | J Clin Invest | 1960 | 13846364 | Yes |
| 2002 | 1374 | 1374.0 | 58.08 | 58.1 | Cognitive reserve in ageing and Alzheimer's disease. | Yaakov Stern | Lancet Neurol | 2012 | 23079557 | No |
| 2003 | 2746 | 1373.0 | 82.68 | 41.3 | Glycine potentiates the NMDA response in cultured mouse brain neurons. | J W Johnson, P Ascher | Nature | 1987 | 2433595 | Yes |
| 2004 | 1373 | 1373.0 | 0.0 | 0.0 | An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. | O Smithies | Biochem J | 1959 | 13638269 | Yes |
| 2005 | 1373 | 1373.0 | 34.27 | 34.3 | The use of nanocrystals in biological detection. | Paul Alivisatos | Nat Biotechnol | 2004 | 14704706 | Yes |
| 2006 | 1372 | 1372.0 | 0.0 | 0.0 | Effects of varying the vehicle for OsO4 in tissue fixation. | J B Caulfield | J Biophys Biochem Cytol | 1957 | 13475399 | Yes |
| 2007 | 2743 | 1371.5 | 0.0 | 0.0 | Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. | A J Berk, P A Sharp | Cell | 1977 | 922889 | Yes |
| 2008 | 2742 | 1371.0 | 84.22 | 42.1 | From best evidence to best practice: effective implementation of change in patients' care. | Richard Grol, Jeremy Grimshaw | Lancet | 2003 | 14568747 | No |
| 2009 | 1370 | 1370.0 | 46.14 | 46.1 | Interleukin-1. | C A Dinarello | Rev Infect Dis | 1984 | 6369481 | No |
| 2010 | 1370 | 1370.0 | 48.69 | 48.7 | The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. | E J Khantzian | Harv Rev Psychiatry | 1997 | 9385000 | No |
| 2011 | 2739 | 1369.5 | 70.72 | 35.4 | Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. | D Marion, K Wüthrich | Biochem Biophys Res Commun | 1983 | 6307308 | Yes |
| 2012 | 2738 | 1369.0 | 0.0 | 0.0 | Peptidoglycan types of bacterial cell walls and their taxonomic implications. | K H Schleifer, O Kandler | Bacteriol Rev | 1972 | 4568761 | No |
| 2013 | 1369 | 1369.0 | 49.39 | 49.4 | Colorimetric determination of phospholipids with ammonium ferrothiocyanate. | J C Stewart | Anal Biochem | 1980 | 6892980 | Yes |
| 2014 | 2737 | 1368.5 | 68.07 | 34.0 | Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. | E S Lander, D Botstein | Genetics | 1989 | 2563713 | Yes |
| 2015 | 2736 | 1368.0 | 88.39 | 44.2 | Unidentified curved bacilli on gastric epithelium in active chronic gastritis. | J R Warren, B Marshall | Lancet | 1983 | 6134060 | Yes |
| 2016 | 2735 | 1367.5 | 66.69 | 33.3 | Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. | H Cai, D G Harrison | Circ Res | 2000 | 11073878 | No |
| 2017 | 17751 | 1365.5 | 489.0 | 37.6 | Clustal W and Clustal X version 2.0. | M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G Higgins | Bioinformatics | 2007 | 17846036 | Yes |
| 2018 | 2730 | 1365.0 | 99.77 | 49.9 | Biology of disease: free radicals and tissue injury. | B A Freeman, J D Crapo | Lab Invest | 1982 | 6290784 | No |
| 2019 | 1364 | 1364.0 | 31.44 | 31.4 | The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. | S E Kahn | Diabetologia | 2003 | 12637977 | No |
| 2020 | 1364 | 1364.0 | 37.04 | 37.0 | The world health report 2002 - reducing risks, promoting healthy life. | J J Guilbert | Educ Health (Abingdon) | 2003 | 14741909 | Yes |
| 2021 | 2728 | 1364.0 | 57.1 | 28.6 | Intrinsically unstructured proteins and their functions. | H Jane Dyson, Peter E Wright | Nat Rev Mol Cell Biol | 2005 | 15738986 | No |
| 2022 | 2728 | 1364.0 | 100.36 | 50.2 | Genome editing. The new frontier of genome engineering with CRISPR-Cas9. | Jennifer A Doudna, Emmanuelle Charpentier | Science | 2014 | 25430774 | No |
| 2023 | 2725 | 1362.5 | 86.17 | 43.1 | Performing the exact test of Hardy-Weinberg proportion for multiple alleles. | S W Guo, E A Thompson | Biometrics | 1992 | 1637966 | Yes |
| 2024 | 1362 | 1362.0 | 30.47 | 30.5 | Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. | M Kozak | Microbiol Rev | 1983 | 6343825 | No |
| 2025 | 2724 | 1362.0 | 97.77 | 48.9 | Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. | M M Bradley, P J Lang | J Behav Ther Exp Psychiatry | 1994 | 7962581 | Yes |
| 2026 | 1362 | 1362.0 | 35.03 | 35.0 | The amygdala modulates the consolidation of memories of emotionally arousing experiences. | James L McGaugh | Annu Rev Neurosci | 2004 | 15217324 | No |
| 2027 | 4083 | 1361.0 | 0.0 | 0.0 | Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. | J Garnier, D J Osguthorpe, B Robson | J Mol Biol | 1978 | 642007 | Yes |
| 2028 | 1361 | 1361.0 | 47.88 | 47.9 | Multiple calcium channels and neuronal function. | R J Miller | Science | 1987 | 2432656 | No |
| 2029 | 1361 | 1361.0 | 46.58 | 46.6 | Aging, cellular senescence, and cancer. | Judith Campisi | Annu Rev Physiol | 2013 | 23140366 | No |
| 2030 | 1360 | 1360.0 | 25.44 | 25.4 | The DNA methyltransferases of mammals. | T H Bestor | Hum Mol Genet | 2000 | 11005794 | No |
| 2031 | 4079 | 1359.7 | 92.85 | 30.9 | Osteoclast differentiation and activation. | William J Boyle, W Scott Simonet, David L Lacey | Nature | 2003 | 12748652 | No |
| 2032 | 1359 | 1359.0 | 46.85 | 46.9 | Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. | K Anders Ericsson | Acad Med | 2004 | 15383395 | No |
| 2033 | 2716 | 1358.0 | 0.0 | 0.0 | A protein sequenator. | P Edman, G Begg | Eur J Biochem | 1967 | 6059350 | Yes |
| 2034 | 1358 | 1358.0 | 36.78 | 36.8 | Understanding biofilm resistance to antibacterial agents. | David Davies | Nat Rev Drug Discov | 2003 | 12563302 | No |
| 2035 | 2715 | 1357.5 | 0.0 | 0.0 | Selective loss of central cholinergic neurons in Alzheimer's disease. | P Davies, A J Maloney | Lancet | 1976 | 63862 | Yes |
| 2036 | 1357 | 1357.0 | 0.0 | 0.0 | Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. | T Spector | Anal Biochem | 1978 | 655375 | Yes |
| 2037 | 1357 | 1357.0 | 45.77 | 45.8 | Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. | N Krieger | Am J Public Health | 1992 | 1566949 | Yes |
| 2038 | 1356 | 1356.0 | 62.71 | 62.7 | Whatever next? Predictive brains, situated agents, and the future of cognitive science. | Andy Clark | Behav Brain Sci | 2013 | 23663408 | No |
| 2039 | 2711 | 1355.5 | 68.5 | 34.2 | Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. | M D Pierschbacher, E Ruoslahti | Nature | 1984 | 6325925 | Yes |
| 2040 | 1355 | 1355.0 | 0.0 | 0.0 | Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. | J R David | Proc Natl Acad Sci U S A | 1966 | 5229858 | Yes |
| 2041 | 1354 | 1354.0 | 31.34 | 31.3 | Hyaluronan: from extracellular glue to pericellular cue. | Bryan P Toole | Nat Rev Cancer | 2004 | 15229478 | No |
| 2042 | 2707 | 1353.5 | 77.53 | 38.8 | Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. | F D Lublin, S C Reingold | Neurology | 1996 | 8780061 | Yes |
| 2043 | 4060 | 1353.3 | 106.58 | 35.5 | Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. | B Fischl, M I Sereno, A M Dale | Neuroimage | 1999 | 9931269 | Yes |
| 2044 | 2706 | 1353.0 | 0.0 | 0.0 | Synchronization of Plasmodium falciparum erythrocytic stages in culture. | C Lambros, J P Vanderberg | J Parasitol | 1979 | 383936 | Yes |
| 2045 | 1352 | 1352.0 | 33.61 | 33.6 | Upconversion and anti-Stokes processes with f and d ions in solids. | François Auzel | Chem Rev | 2004 | 14719973 | Yes |
| 2046 | 4055 | 1351.7 | 0.0 | 0.0 | Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. | D D Sabatini, K Bensch, R J Barrnett | J Cell Biol | 1963 | 13975866 | Yes |
| 2047 | 21619 | 1351.2 | 782.2 | 48.9 | Fiji: an open-source platform for biological-image analysis. | Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert Cardona | Nat Methods | 2012 | 22743772 | Yes |
| 2048 | 2702 | 1351.0 | 54.62 | 27.3 | Cancer genes and the pathways they control. | Bert Vogelstein, Kenneth W Kinzler | Nat Med | 2004 | 15286780 | No |
| 2049 | 2702 | 1351.0 | 104.33 | 52.2 | The integrative review: updated methodology. | Robin Whittemore, Kathleen Knafl | J Adv Nurs | 2005 | 16268861 | Yes |
| 2050 | 1351 | 1351.0 | 45.28 | 45.3 | Stress and disorders of the stress system. | George P Chrousos | Nat Rev Endocrinol | 2009 | 19488073 | No |
| 2051 | 1350 | 1350.0 | 37.23 | 37.2 | Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. | Michael F Holick | Am J Clin Nutr | 2004 | 15585788 | No |
| 2052 | 2699 | 1349.5 | 0.0 | 0.0 | Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. | A Dahlstroem, K Fuxe | Acta Physiol Scand Suppl | 1964 | 14229500 | Yes |
| 2053 | 1349 | 1349.0 | 43.43 | 43.4 | The functional gastrointestinal disorders and the Rome III process. | Douglas A Drossman | Gastroenterology | 2006 | 16678553 | No |
| 2054 | 1349 | 1349.0 | 41.37 | 41.4 | Understanding organofluorine chemistry. An introduction to the C-F bond. | David O'Hagan | Chem Soc Rev | 2008 | 18197347 | No |
| 2055 | 1349 | 1349.0 | 47.94 | 47.9 | A Social Neuroscience Perspective on Adolescent Risk-Taking. | Laurence Steinberg | Dev Rev | 2008 | 18509515 | Yes |
| 2056 | 2696 | 1348.0 | 69.14 | 34.6 | Molecular beacons: probes that fluoresce upon hybridization. | S Tyagi, F R Kramer | Nat Biotechnol | 1996 | 9630890 | Yes |
| 2057 | 1348 | 1348.0 | 37.66 | 37.7 | Synergy, antagonism, and what the chequerboard puts between them. | F C Odds | J Antimicrob Chemother | 2003 | 12805255 | No |
| 2058 | 1347 | 1347.0 | 0.0 | 0.0 | Stereological principles for morphometry in electron microscopic cytology. | E R Weibel | Int Rev Cytol | 1969 | 4899604 | No |
| 2059 | 2694 | 1347.0 | 77.84 | 38.9 | Mortality by cause for eight regions of the world: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9142060 | Yes |
| 2060 | 2693 | 1346.5 | 0.0 | 0.0 | Virus interference. I. The interferon. | A Isaacs, J Lindenmann | Proc R Soc Lond B Biol Sci | 1957 | 13465720 | Yes |
| 2061 | 2693 | 1346.5 | 164.9 | 82.5 | Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2016 | 27095192 | Yes |
| 2062 | 1346 | 1346.0 | 0.0 | 0.0 | Immunological function of the thymus. | J F Miller | Lancet | 1961 | 14474038 | Yes |
| 2063 | 1345 | 1345.0 | 0.0 | 0.0 | Blood gas calculator. | J W Severinghaus | J Appl Physiol | 1966 | 5912737 | Yes |
| 2064 | 1345 | 1345.0 | 30.69 | 30.7 | Autophagy: from phenomenology to molecular understanding in less than a decade. | Daniel J Klionsky | Nat Rev Mol Cell Biol | 2007 | 17712358 | No |
| 2065 | 1345 | 1345.0 | 29.54 | 29.5 | Maintenance of C. elegans. | Theresa Stiernagle | WormBook | 2006 | 18050451 | No |
| 2066 | 2687 | 1343.5 | 0.0 | 0.0 | Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. | E Engvall, P Perlmann | Immunochemistry | 1971 | 5135623 | Yes |
| 2067 | 2687 | 1343.5 | 0.0 | 0.0 | The respiratory chain and oxidative phosphorylation. | B Chance, G R Williams | Adv Enzymol Relat Subj Biochem | 1956 | 13313307 | Yes |
| 2068 | 2687 | 1343.5 | 77.02 | 38.5 | Materials for electrochemical capacitors. | Patrice Simon, Yury Gogotsi | Nat Mater | 2008 | 18956000 | Yes |
| 2069 | 5373 | 1343.2 | 289.57 | 72.4 | Prevalence of childhood and adult obesity in the United States, 2011-2012. | Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M Flegal | JAMA | 2014 | 24570244 | Yes |
| 2070 | 2686 | 1343.0 | 62.95 | 31.5 | NF-kappa B: ten years after. | P A Baeuerle, D Baltimore | Cell | 1996 | 8858144 | No |
| 2071 | 1343 | 1343.0 | 0.0 | 0.0 | A modified procedure for lead staining of thin sections. | G Millonig | J Biophys Biochem Cytol | 1961 | 14474176 | Yes |
| 2072 | 1342 | 1342.0 | 32.9 | 32.9 | Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. | G von Heijne | J Mol Biol | 1992 | 1593632 | Yes |
| 2073 | 2684 | 1342.0 | 75.61 | 37.8 | Bronchopulmonary dysplasia. | A H Jobe, E Bancalari | Am J Respir Crit Care Med | 2001 | 11401896 | No |
| 2074 | 1342 | 1342.0 | 0.0 | 0.0 | The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. | R C Lewontin | Genetics | 1964 | 17248194 | Yes |
| 2075 | 2682 | 1341.0 | 51.62 | 25.8 | Oncogenic kinase signalling. | P Blume-Jensen, T Hunter | Nature | 2001 | 11357143 | No |
| 2076 | 2681 | 1340.5 | 91.96 | 46.0 | Thermodynamics of protein association reactions: forces contributing to stability. | P D Ross, S Subramanian | Biochemistry | 1981 | 7248271 | Yes |
| 2077 | 2680 | 1340.0 | 0.0 | 0.0 | Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. | G J Miller, N E Miller | Lancet | 1975 | 46338 | Yes |
| 2078 | 1340 | 1340.0 | 41.17 | 41.2 | Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. | M Robin DiMatteo | Med Care | 2004 | 15076819 | Yes |
| 2079 | 2679 | 1339.5 | 0.0 | 0.0 | A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. | J A Horne, O Ostberg | Int J Chronobiol | 1976 | 1027738 | Yes |
| 2080 | 2679 | 1339.5 | 0.0 | 0.0 | Further improvements in the plaque technique for detecting single antibody-forming cells. | A J Cunningham, A Szenberg | Immunology | 1968 | 5653817 | Yes |
| 2081 | 1339 | 1339.0 | 41.36 | 41.4 | Neurotransmitters and neuromodulators in the basal ganglia. | A M Graybiel | Trends Neurosci | 1990 | 1695398 | No |
| 2082 | 1339 | 1339.0 | 45.49 | 45.5 | The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. | Poul Erik Petersen | Community Dent Oral Epidemiol | 2003 | 15015736 | Yes |
| 2083 | 2678 | 1339.0 | 76.35 | 38.2 | Regulation of chromatin by histone modifications. | Andrew J Bannister, Tony Kouzarides | Cell Res | 2011 | 21321607 | No |
| 2084 | 2677 | 1338.5 | 54.72 | 27.4 | Wnt signalling in stem cells and cancer. | Tannishtha Reya, Hans Clevers | Nature | 2005 | 15829953 | No |
| 2085 | 1338 | 1338.0 | 39.23 | 39.2 | The origins of the developmental origins theory. | D J P Barker | J Intern Med | 2007 | 17444880 | No |
| 2086 | 1337 | 1337.0 | 34.57 | 34.6 | Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. | Y Shai | Biochim Biophys Acta | 1999 | 10590302 | No |
| 2087 | 1337 | 1337.0 | 0.0 | 0.0 | Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. | K Fuxe | Acta Physiol Scand Suppl | 1965 | 14319769 | Yes |
| 2088 | 1337 | 1337.0 | 41.69 | 41.7 | A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. | Ozcan Erel | Clin Biochem | 2004 | 15003729 | Yes |
| 2089 | 1337 | 1337.0 | 34.61 | 34.6 | Origin, biogenesis, and activity of plant microRNAs. | Olivier Voinnet | Cell | 2009 | 19239888 | No |
| 2090 | 2672 | 1336.0 | 0.0 | 0.0 | Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. | E Engvall, P Perlmann | J Immunol | 1972 | 4113792 | Yes |
| 2091 | 2672 | 1336.0 | 95.52 | 47.8 | A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. | C M Tsai, C E Frasch | Anal Biochem | 1982 | 6176137 | Yes |
| 2092 | 1336 | 1336.0 | 35.08 | 35.1 | Interoception: the sense of the physiological condition of the body. | A D Craig | Curr Opin Neurobiol | 2003 | 12965300 | No |
| 2093 | 1336 | 1336.0 | 38.56 | 38.6 | Bioactive microbial metabolites. | János Bérdy | J Antibiot (Tokyo) | 2005 | 15813176 | No |
| 2094 | 2671 | 1335.5 | 76.59 | 38.3 | Lipid rafts as a membrane-organizing principle. | Daniel Lingwood, Kai Simons | Science | 2010 | 20044567 | No |
| 2095 | 1335 | 1335.0 | 49.17 | 49.2 | Asthma phenotypes: the evolution from clinical to molecular approaches. | Sally E Wenzel | Nat Med | 2012 | 22561835 | No |
| 2096 | 1334 | 1334.0 | 0.0 | 0.0 | Origin of concatemeric T7 DNA. | J D Watson | Nat New Biol | 1972 | 4507727 | Yes |
| 2097 | 2667 | 1333.5 | 57.43 | 28.7 | The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. | M S Brown, J L Goldstein | Cell | 1997 | 9150132 | No |
| 2098 | 2667 | 1333.5 | 90.31 | 45.2 | Oncology meets immunology: the cancer-immunity cycle. | Daniel S Chen, Ira Mellman | Immunity | 2013 | 23890059 | No |
| 2099 | 5332 | 1333.0 | 0.0 | 0.0 | Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. | D W Cleveland, S G Fischer, M W Kirschner, U K Laemmli | J Biol Chem | 1977 | 320200 | Yes |
| 2100 | 1333 | 1333.0 | 35.94 | 35.9 | Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. | S L Friedman | N Engl J Med | 1993 | 8502273 | No |
| 2101 | 2666 | 1333.0 | 61.85 | 30.9 | The pathophysiology and treatment of sepsis. | Richard S Hotchkiss, Irene E Karl | N Engl J Med | 2003 | 12519925 | No |
| 2102 | 1332 | 1332.0 | 45.35 | 45.4 | Gene flow and the geographic structure of natural populations. | M Slatkin | Science | 1987 | 3576198 | Yes |
| 2103 | 1332 | 1332.0 | 27.11 | 27.1 | Dimerization of cell surface receptors in signal transduction. | C H Heldin | Cell | 1995 | 7834741 | No |
| 2104 | 1332 | 1332.0 | 0.0 | 0.0 | The Relation Of Recombination To Mutational Advance. | H J Muller | Mutat Res | 1964 | 14195748 | Yes |
| 2105 | 2663 | 1331.5 | 55.44 | 27.7 | Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. | P J Southern, P Berg | J Mol Appl Genet | 1982 | 6286831 | Yes |
| 2106 | 1331 | 1331.0 | 65.08 | 65.1 | Molecular pathology of schizophrenia: more than one disease process? | T J Crow | Br Med J | 1980 | 6101544 | No |
| 2107 | 2661 | 1330.5 | 0.0 | 0.0 | Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. | G Blobel, B Dobberstein | J Cell Biol | 1975 | 811671 | Yes |
| 2108 | 2660 | 1330.0 | 53.08 | 26.5 | Autophagy as a regulated pathway of cellular degradation. | D J Klionsky, S D Emr | Science | 2000 | 11099404 | No |
| 2109 | 3990 | 1330.0 | 0.0 | 0.0 | Improved method for the determination of blood glutathione. | E Beutler, O Duron, B M Kelly | J Lab Clin Med | 1963 | 13967893 | Yes |
| 2110 | 1330 | 1330.0 | 29.55 | 29.6 | A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. | Dale R Nyholt | Am J Hum Genet | 2004 | 14997420 | Yes |
| 2111 | 1329 | 1329.0 | 0.0 | 0.0 | Renin-angiotensin system: biochemistry and mechanisms of action. | M J Peach | Physiol Rev | 1977 | 191856 | No |
| 2112 | 2658 | 1329.0 | 0.0 | 0.0 | Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. | D H Figurski, D R Helinski | Proc Natl Acad Sci U S A | 1979 | 377280 | Yes |
| 2113 | 1329 | 1329.0 | 74.26 | 74.3 | The brain's default mode network. | Marcus E Raichle | Annu Rev Neurosci | 2015 | 25938726 | No |
| 2114 | 3985 | 1328.3 | 116.81 | 38.9 | I-TASSER: a unified platform for automated protein structure and function prediction. | Ambrish Roy, Alper Kucukural, Yang Zhang | Nat Protoc | 2010 | 20360767 | Yes |
| 2115 | 1328 | 1328.0 | 0.0 | 0.0 | Mate selection-a selection for a handicap. | A Zahavi | J Theor Biol | 1975 | 1195756 | Yes |
| 2116 | 1328 | 1328.0 | 0.0 | 0.0 | Cellular resistance to infection. | G B Mackaness | J Exp Med | 1962 | 14467923 | Yes |
| 2117 | 5310 | 1327.5 | 124.81 | 31.2 | Quantitative monitoring of gene expression patterns with a complementary DNA microarray. | M Schena, D Shalon, R W Davis, P O Brown | Science | 1995 | 7569999 | Yes |
| 2118 | 1327 | 1327.0 | 47.75 | 47.8 | Neuropeptide Y: complete amino acid sequence of the brain peptide. | K Tatemoto | Proc Natl Acad Sci U S A | 1982 | 6957876 | Yes |
| 2119 | 1326 | 1326.0 | 41.98 | 42.0 | The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. | L W Swanson | Brain Res Bull | 1982 | 6816390 | Yes |
| 2120 | 1326 | 1326.0 | 43.3 | 43.3 | History of the Rochester Epidemiology Project. | L J Melton | Mayo Clin Proc | 1996 | 8594285 | No |
| 2121 | 1326 | 1326.0 | 28.04 | 28.0 | Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. | R I Morimoto | Genes Dev | 1998 | 9869631 | No |
| 2122 | 1325 | 1325.0 | 87.1 | 87.1 | The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. | F Denis | Spine (Phila Pa 1976) | 1983 | 6670016 | Yes |
| 2123 | 1325 | 1325.0 | 36.38 | 36.4 | A note on robust variance estimation for cluster-correlated data. | R L Williams | Biometrics | 2000 | 10877330 | Yes |
| 2124 | 1325 | 1325.0 | 39.87 | 39.9 | Multiple imputation of discrete and continuous data by fully conditional specification. | Stef van Buuren | Stat Methods Med Res | 2007 | 17621469 | Yes |
| 2125 | 2649 | 1324.5 | 0.0 | 0.0 | Immunization of dissociated spleen cell cultures from normal mice. | R I Mishell, R W Dutton | J Exp Med | 1967 | 6034749 | Yes |
| 2126 | 2649 | 1324.5 | 79.66 | 39.8 | What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. | J Zhang, K F Yu | JAMA | 1998 | 9832001 | Yes |
| 2127 | 1324 | 1324.0 | 57.29 | 57.3 | The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. | E J Khantzian | Am J Psychiatry | 1985 | 3904487 | No |
| 2128 | 1324 | 1324.0 | 26.12 | 26.1 | Chromosomal translocations in human cancer. | T H Rabbitts | Nature | 1994 | 7969446 | No |
| 2129 | 1324 | 1324.0 | 44.08 | 44.1 | SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. | B P O'Connor | Behav Res Methods Instrum Comput | 2000 | 11029811 | Yes |
| 2130 | 1324 | 1324.0 | 36.16 | 36.2 | The epidemiology of venous thromboembolism. | Richard H White | Circulation | 2003 | 12814979 | No |
| 2131 | 1324 | 1324.0 | 29.98 | 30.0 | Critical period plasticity in local cortical circuits. | Takao K Hensch | Nat Rev Neurosci | 2005 | 16261181 | No |
| 2132 | 3970 | 1323.3 | 123.98 | 41.3 | Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. | S van der Linden, H A Valkenburg, A Cats | Arthritis Rheum | 1984 | 6231933 | Yes |
| 2133 | 1323 | 1323.0 | 34.49 | 34.5 | Clinical features of metastatic bone disease and risk of skeletal morbidity. | Robert E Coleman | Clin Cancer Res | 2006 | 17062708 | No |
| 2134 | 1322 | 1322.0 | 35.54 | 35.5 | Fibronectin and its receptors. | E Ruoslahti | Annu Rev Biochem | 1988 | 2972252 | No |
| 2135 | 1322 | 1322.0 | 42.6 | 42.6 | Glutathione metabolism and its selective modification. | A Meister | J Biol Chem | 1988 | 3053703 | No |
| 2136 | 3965 | 1321.7 | 142.21 | 47.4 | Structure-antioxidant activity relationships of flavonoids and phenolic acids. | C A Rice-Evans, N J Miller, G Paganga | Free Radic Biol Med | 1996 | 8743980 | Yes |
| 2137 | 1321 | 1321.0 | 65.07 | 65.1 | Optical properties of biological tissues: a review. | Steven L Jacques | Phys Med Biol | 2013 | 23666068 | No |
| 2138 | 1320 | 1320.0 | 41.67 | 41.7 | Ordinary magic. Resilience processes in development. | A S Masten | Am Psychol | 2001 | 11315249 | Yes |
| 2139 | 1320 | 1320.0 | 0.0 | 0.0 | A simple ultraviolet spectrophotometric method for the determination of protein. | W J Waddell | J Lab Clin Med | 1956 | 13346201 | Yes |
| 2140 | 1320 | 1320.0 | 33.22 | 33.2 | Drug-induced prolongation of the QT interval. | Dan M Roden | N Engl J Med | 2004 | 14999113 | No |
| 2141 | 2638 | 1319.0 | 78.43 | 39.2 | Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9164317 | Yes |
| 2142 | 1319 | 1319.0 | 33.18 | 33.2 | Tobacco smoke carcinogens and lung cancer. | S S Hecht | J Natl Cancer Inst | 1999 | 10413421 | No |
| 2143 | 1319 | 1319.0 | 0.0 | 0.0 | A quantitative immunochemical measure of the primary interaction between I BSA and antibody. | R S Farr | J Infect Dis | 1958 | 13611294 | Yes |
| 2144 | 2637 | 1318.5 | 0.0 | 0.0 | Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. | L F Berkman, S L Syme | Am J Epidemiol | 1979 | 425958 | Yes |
| 2145 | 1318 | 1318.0 | 34.87 | 34.9 | The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. | K Kuwajima | Proteins | 1989 | 2695928 | No |
| 2146 | 1318 | 1318.0 | 41.95 | 42.0 | The phenomenon of the acute phase response. | I Kushner | Ann N Y Acad Sci | 1982 | 7046585 | No |
| 2147 | 2636 | 1318.0 | 60.63 | 30.3 | Integrins and signal transduction pathways: the road taken. | E A Clark, J S Brugge | Science | 1995 | 7716514 | No |
| 2148 | 1318 | 1318.0 | 29.47 | 29.5 | Cancer of the ovary. | Stephen A Cannistra | N Engl J Med | 2004 | 15590954 | No |
| 2149 | 2635 | 1317.5 | 60.98 | 30.5 | The RXR heterodimers and orphan receptors. | D J Mangelsdorf, R M Evans | Cell | 1995 | 8521508 | No |
| 2150 | 1317 | 1317.0 | 0.0 | 0.0 | Letter: Grading of angina pectoris. | L Campeau | Circulation | 1976 | 947585 | Yes |
| 2151 | 1317 | 1317.0 | 0.0 | 0.0 | Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. | W W Douglas | Br J Pharmacol | 1968 | 4882190 | No |
| 2152 | 1316 | 1316.0 | 0.0 | 0.0 | The prevalence of 'alexithymic' characteristics in psychosomatic patients. | P E Sifneos | Psychother Psychosom | 1973 | 4770536 | Yes |
| 2153 | 1316 | 1316.0 | 31.64 | 31.6 | Regulation of differentiation of vascular smooth muscle cells. | G K Owens | Physiol Rev | 1995 | 7624392 | No |
| 2154 | 1316 | 1316.0 | 26.73 | 26.7 | Natively unfolded proteins: a point where biology waits for physics. | Vladimir N Uversky | Protein Sci | 2002 | 11910019 | No |
| 2155 | 1316 | 1316.0 | 30.47 | 30.5 | Mitochondria: dynamic organelles in disease, aging, and development. | David C Chan | Cell | 2006 | 16814712 | No |
| 2156 | 2631 | 1315.5 | 99.11 | 49.6 | Universal chemical assay for the detection and determination of siderophores. | B Schwyn, J B Neilands | Anal Biochem | 1987 | 2952030 | Yes |
| 2157 | 2631 | 1315.5 | 0.0 | 0.0 | A new scale of social desirability independent of psychopathology. | D P Crowne, D Marlowe | J Consult Psychol | 1960 | 13813058 | Yes |
| 2158 | 1315 | 1315.0 | 30.69 | 30.7 | Molecular basis of long-term plasticity underlying addiction. | E J Nestler | Nat Rev Neurosci | 2001 | 11252991 | No |
| 2159 | 1315 | 1315.0 | 25.81 | 25.8 | Epithelial-mesenchymal transitions in development and pathologies. | Jean Paul Thiery | Curr Opin Cell Biol | 2003 | 14644200 | No |
| 2160 | 1315 | 1315.0 | 0.0 | 0.0 | Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. | P F Scholander | J Biol Chem | 1947 | 20281644 | Yes |
| 2161 | 1314 | 1314.0 | 29.88 | 29.9 | Gene finding in novel genomes. | Ian Korf | BMC Bioinformatics | 2004 | 15144565 | Yes |
| 2162 | 2628 | 1314.0 | 183.6 | 91.8 | Natural Products as Sources of New Drugs from 1981 to 2014. | David J Newman, Gordon M Cragg | J Nat Prod | 2016 | 26852623 | No |
| 2163 | 3941 | 1313.7 | 104.87 | 35.0 | The metabolic syndrome. | Robert H Eckel, Scott M Grundy, Paul Z Zimmet | Lancet | 2005 | 15836891 | No |
| 2164 | 1313 | 1313.0 | 33.73 | 33.7 | Thioredoxin and glutaredoxin systems. | A Holmgren | J Biol Chem | 1989 | 2668278 | No |
| 2165 | 1313 | 1313.0 | 50.76 | 50.8 | Presidential address, 1980. Surprise!...Surprise? | E Donchin | Psychophysiology | 1981 | 7280146 | Yes |
| 2166 | 1313 | 1313.0 | 0.0 | 0.0 | Agammaglobulinemia. | O C Bruton | Pediatrics | 1952 | 14929630 | Yes |
| 2167 | 7876 | 1312.7 | 280.59 | 46.8 | TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. | Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg | Genome Biol | 2013 | 23618408 | Yes |
| 2168 | 2625 | 1312.5 | 80.79 | 40.4 | Genome regulation by long noncoding RNAs. | John L Rinn, Howard Y Chang | Annu Rev Biochem | 2012 | 22663078 | No |
| 2169 | 1312 | 1312.0 | 34.38 | 34.4 | The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. | T Szkudelski | Physiol Res | 2001 | 11829314 | No |
| 2170 | 1312 | 1312.0 | 39.92 | 39.9 | Recent developments in isocyanide based multicomponent reactions in applied chemistry. | Alexander Dömling | Chem Rev | 2006 | 16402771 | No |
| 2171 | 1312 | 1312.0 | 43.07 | 43.1 | Signal transduction by reactive oxygen species. | Toren Finkel | J Cell Biol | 2011 | 21746850 | No |
| 2172 | 2623 | 1311.5 | 69.56 | 34.8 | Cell signaling by receptor tyrosine kinases. | Mark A Lemmon, Joseph Schlessinger | Cell | 2010 | 20602996 | No |
| 2173 | 1311 | 1311.0 | 31.63 | 31.6 | Apoptosis in cancer therapy: crossing the threshold. | D E Fisher | Cell | 1994 | 8069905 | No |
| 2174 | 3933 | 1311.0 | 104.37 | 34.8 | How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. | R M Sapolsky, L M Romero, A U Munck | Endocr Rev | 2000 | 10696570 | No |
| 2175 | 1311 | 1311.0 | 43.13 | 43.1 | The law of attrition. | Gunther Eysenbach | J Med Internet Res | 2005 | 15829473 | Yes |
| 2176 | 2620 | 1310.0 | 0.0 | 0.0 | A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. | R L Juliano, V Ling | Biochim Biophys Acta | 1976 | 990323 | Yes |
| 2177 | 1310 | 1310.0 | 33.82 | 33.8 | N-heterocyclic carbenes: a new concept in organometallic catalysis. | Wolfgang A Herrmann | Angew Chem Int Ed Engl | 2002 | 19750753 | Yes |
| 2178 | 2619 | 1309.5 | 82.28 | 41.1 | The benefits of being present: mindfulness and its role in psychological well-being. | Kirk Warren Brown, Richard M Ryan | J Pers Soc Psychol | 2003 | 12703651 | Yes |
| 2179 | 1309 | 1309.0 | 52.53 | 52.5 | Reliability and factor analysis of the Epworth Sleepiness Scale. | M W Johns | Sleep | 1992 | 1519015 | Yes |
| 2180 | 2618 | 1309.0 | 60.13 | 30.1 | Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. | E Y Chen, P H Seeburg | DNA | 1985 | 3996185 | Yes |
| 2181 | 1309 | 1309.0 | 29.89 | 29.9 | Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. | W D Snider | Cell | 1994 | 8205613 | No |
| 2182 | 2618 | 1309.0 | 55.17 | 27.6 | Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. | J M Kyriakis, J Avruch | Physiol Rev | 2001 | 11274345 | No |
| 2183 | 1309 | 1309.0 | 24.09 | 24.1 | The snail superfamily of zinc-finger transcription factors. | M Angela Nieto | Nat Rev Mol Cell Biol | 2002 | 11994736 | No |
| 2184 | 1309 | 1309.0 | 22.33 | 22.3 | Cancer. Addiction to oncogenes--the Achilles heal of cancer. | I Bernard Weinstein | Science | 2002 | 12098689 | No |
| 2185 | 1309 | 1309.0 | 31.22 | 31.2 | Cell signaling. H2O2, a necessary evil for cell signaling. | Sue Goo Rhee | Science | 2006 | 16809515 | Yes |
| 2186 | 1309 | 1309.0 | 43.09 | 43.1 | Formation of glasses from liquids and biopolymers. | C A Angell | Science | 1995 | 17770101 | Yes |
| 2187 | 3925 | 1308.3 | 98.21 | 32.7 | The p53 tumour suppressor gene. | A J Levine, J Momand, C A Finlay | Nature | 1991 | 2046748 | No |
| 2188 | 1308 | 1308.0 | 41.03 | 41.0 | Biological basis of the behavior of sick animals. | B L Hart | Neurosci Biobehav Rev | 1988 | 3050629 | No |
| 2189 | 1308 | 1308.0 | 33.32 | 33.3 | A molecular view of microbial diversity and the biosphere. | N R Pace | Science | 1997 | 9115194 | No |
| 2190 | 1308 | 1308.0 | 29.29 | 29.3 | The ATP synthase--a splendid molecular machine. | P D Boyer | Annu Rev Biochem | 1997 | 9242922 | No |
| 2191 | 1308 | 1308.0 | 42.59 | 42.6 | Chlorophyll fluorescence: a probe of photosynthesis in vivo. | Neil R Baker | Annu Rev Plant Biol | 2008 | 18444897 | No |
| 2192 | 2615 | 1307.5 | 91.69 | 45.8 | The framing of decisions and the psychology of choice. | A Tversky, D Kahneman | Science | 1981 | 7455683 | Yes |
| 2193 | 2615 | 1307.5 | 60.45 | 30.2 | Cellular senescence: when bad things happen to good cells. | Judith Campisi, Fabrizio d'Adda di Fagagna | Nat Rev Mol Cell Biol | 2007 | 17667954 | No |
| 2194 | 1307 | 1307.0 | 42.09 | 42.1 | Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. | A A Grace | Neuroscience | 1991 | 1676137 | No |
| 2195 | 1307 | 1307.0 | 0.0 | 0.0 | Hippocampal electrical activity and voluntary movement in the rat. | C H Vanderwolf | Electroencephalogr Clin Neurophysiol | 1969 | 4183562 | Yes |
| 2196 | 1307 | 1307.0 | 24.21 | 24.2 | Chromatin modification and epigenetic reprogramming in mammalian development. | En Li | Nat Rev Genet | 2002 | 12209141 | No |
| 2197 | 1307 | 1307.0 | 0.0 | 0.0 | Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. | Russell Lande | Evolution | 1979 | 28568194 | Yes |
| 2198 | 1307 | 1307.0 | 91.16 | 91.2 | Metazoan MicroRNAs. | David P Bartel | Cell | 2018 | 29570994 | No |
| 2199 | 2613 | 1306.5 | 70.51 | 35.3 | Abdominal obesity and metabolic syndrome. | Jean-Pierre Després, Isabelle Lemieux | Nature | 2006 | 17167477 | No |
| 2200 | 3919 | 1306.3 | 185.77 | 61.9 | Risk factors for falls among elderly persons living in the community. | M E Tinetti, M Speechley, S F Ginter | N Engl J Med | 1988 | 3205267 | Yes |
| 2201 | 1306 | 1306.0 | 50.84 | 50.8 | Free-radical mechanisms in tissue injury. | T F Slater | Biochem J | 1984 | 6383353 | No |
| 2202 | 1306 | 1306.0 | 0.0 | 0.0 | A New Weighting System For Mean Surface Temperature Of The Human Body. | N L Ramanathan | J Appl Physiol | 1964 | 14173555 | Yes |
| 2203 | 1306 | 1306.0 | 38.56 | 38.6 | The debate over dopamine's role in reward: the case for incentive salience. | Kent C Berridge | Psychopharmacology (Berl) | 2007 | 17072591 | No |
| 2204 | 2611 | 1305.5 | 57.7 | 28.9 | NMR View: A computer program for the visualization and analysis of NMR data. | B A Johnson, R A Blevins | J Biomol NMR | 1994 | 22911360 | Yes |
| 2205 | 11745 | 1305.0 | 371.84 | 41.3 | The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. | D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C Dunbar | J Clin Psychiatry | 1998 | 9881538 | No |
| 2206 | 1305 | 1305.0 | 0.0 | 0.0 | The antidiuretic hormone and the factors which determine its release. | E B Verney | Proc R Soc Lond B Biol Sci | 1947 | 18918876 | Yes |
| 2207 | 2610 | 1305.0 | 63.89 | 31.9 | The DNA damage response: making it safe to play with knives. | Alberto Ciccia, Stephen J Elledge | Mol Cell | 2010 | 20965415 | No |
| 2208 | 2609 | 1304.5 | 60.36 | 30.2 | Disruption of epithelial cell-matrix interactions induces apoptosis. | S M Frisch, H Francis | J Cell Biol | 1994 | 8106557 | Yes |
| 2209 | 1304 | 1304.0 | 27.91 | 27.9 | Double identity for proteins of the Bcl-2 family. | J C Reed | Nature | 1997 | 9194558 | No |
| 2210 | 1303 | 1303.0 | 37.17 | 37.2 | The matrix-degrading metalloproteinases. | L M Matrisian | Bioessays | 1992 | 1445287 | No |
| 2211 | 3901 | 1300.3 | 146.92 | 49.0 | CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. | Teresa C Horan, Mary Andrus, Margaret A Dudeck | Am J Infect Control | 2008 | 18538699 | No |
| 2212 | 1300 | 1300.0 | 39.21 | 39.2 | Strong localization of photons in certain disordered dielectric superlattices. | John | Phys Rev Lett | 1987 | 10034761 | Yes |
| 2213 | 1300 | 1300.0 | 29.45 | 29.4 | Target-oriented and diversity-oriented organic synthesis in drug discovery. | S L Schreiber | Science | 2000 | 10720315 | No |
| 2214 | 1300 | 1300.0 | 57.59 | 57.6 | Selenium and human health. | Margaret P Rayman | Lancet | 2012 | 22381456 | No |
| 2215 | 1299 | 1299.0 | 64.32 | 64.3 | Chronic illness as biographical disruption. | M Bury | Sociol Health Illn | 1982 | 10260456 | Yes |
| 2216 | 1299 | 1299.0 | 24.86 | 24.9 | The significance of responses of the genome to challenge. | B McClintock | Science | 1984 | 15739260 | No |
| 2217 | 2598 | 1299.0 | 74.49 | 37.2 | The gut microbiota shapes intestinal immune responses during health and disease. | June L Round, Sarkis K Mazmanian | Nat Rev Immunol | 2009 | 19343057 | No |
| 2218 | 2597 | 1298.5 | 60.17 | 30.1 | A comparison of bayesian methods for haplotype reconstruction from population genotype data. | Matthew Stephens, Peter Donnelly | Am J Hum Genet | 2003 | 14574645 | Yes |
| 2219 | 3895 | 1298.3 | 126.55 | 42.2 | Simultaneous inference in general parametric models. | Torsten Hothorn, Frank Bretz, Peter Westfall | Biom J | 2008 | 18481363 | No |
| 2220 | 5193 | 1298.2 | 129.08 | 32.3 | The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. | Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten Schwede | Bioinformatics | 2006 | 16301204 | Yes |
| 2221 | 1298 | 1298.0 | 44.89 | 44.9 | Functional organization of central pathways regulating the cardiovascular system. | R A Dampney | Physiol Rev | 1994 | 8171117 | No |
| 2222 | 2596 | 1298.0 | 118.3 | 59.1 | ROS function in redox signaling and oxidative stress. | Michael Schieber, Navdeep S Chandel | Curr Biol | 2014 | 24845678 | No |
| 2223 | 1297 | 1297.0 | 28.26 | 28.3 | The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. | G B Morin | Cell | 1989 | 2805070 | Yes |
| 2224 | 1297 | 1297.0 | 36.45 | 36.5 | The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. | R G Gerrity | Am J Pathol | 1981 | 7234961 | Yes |
| 2225 | 2594 | 1297.0 | 82.08 | 41.0 | Porosity of 3D biomaterial scaffolds and osteogenesis. | Vassilis Karageorgiou, David Kaplan | Biomaterials | 2005 | 15860204 | No |
| 2226 | 1297 | 1297.0 | 39.7 | 39.7 | Graphene transistors. | Frank Schwierz | Nat Nanotechnol | 2010 | 20512128 | Yes |
| 2227 | 2593 | 1296.5 | 58.21 | 29.1 | Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. | Joshua E Elias, Steven P Gygi | Nat Methods | 2007 | 17327847 | Yes |
| 2228 | 1295 | 1295.0 | 48.52 | 48.5 | Quantitative methods in the review of epidemiologic literature. | S Greenland | Epidemiol Rev | 1987 | 3678409 | Yes |
| 2229 | 1294 | 1294.0 | 24.49 | 24.5 | Antigen-specific interaction between T and B cells. | A Lanzavecchia | Nature | 1985 | 3157869 | Yes |
| 2230 | 2588 | 1294.0 | 61.89 | 30.9 | Production of single-stranded plasmid DNA. | J Vieira, J Messing | Methods Enzymol | 1987 | 3323803 | Yes |
| 2231 | 1294 | 1294.0 | 31.62 | 31.6 | Proinflammatory cytokines. | C A Dinarello | Chest | 2000 | 10936147 | No |
| 2232 | 1294 | 1294.0 | 34.18 | 34.2 | Hemispheric asymmetry reduction in older adults: the HAROLD model. | Roberto Cabeza | Psychol Aging | 2002 | 11931290 | No |
| 2233 | 2587 | 1293.5 | 0.0 | 0.0 | Epidermal growth factor. | G Carpenter, S Cohen | Annu Rev Biochem | 1979 | 382984 | No |
| 2234 | 2585 | 1292.5 | 63.94 | 32.0 | Inflammation, stress, and diabetes. | Kathryn E Wellen, Gökhan S Hotamisligil | J Clin Invest | 2005 | 15864338 | No |
| 2235 | 1292 | 1292.0 | 23.31 | 23.3 | Regulatory T cells: key controllers of immunologic self-tolerance. | S Sakaguchi | Cell | 2000 | 10850488 | No |
| 2236 | 1292 | 1292.0 | 38.49 | 38.5 | Treatment of infections associated with surgical implants. | Rabih O Darouiche | N Engl J Med | 2004 | 15070792 | No |
| 2237 | 1292 | 1292.0 | 34.48 | 34.5 | Marine viruses--major players in the global ecosystem. | Curtis A Suttle | Nat Rev Microbiol | 2007 | 17853907 | No |
| 2238 | 2583 | 1291.5 | 54.5 | 27.2 | A general framework for weighted gene co-expression network analysis. | Bin Zhang, Steve Horvath | Stat Appl Genet Mol Biol | 2005 | 16646834 | Yes |
| 2239 | 5164 | 1291.0 | 154.74 | 38.7 | Reversible middle cerebral artery occlusion without craniectomy in rats. | E Z Longa, P R Weinstein, S Carlson, R Cummins | Stroke | 1989 | 2643202 | Yes |
| 2240 | 1291 | 1291.0 | 24.18 | 24.2 | CD95's deadly mission in the immune system. | P H Krammer | Nature | 2000 | 11048730 | No |
| 2241 | 5161 | 1290.2 | 127.09 | 31.8 | Improved prediction of signal peptides: SignalP 3.0. | Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren Brunak | J Mol Biol | 2004 | 15223320 | Yes |
| 2242 | 1290 | 1290.0 | 31.28 | 31.3 | Receptors for epidermal growth factor and other polypeptide mitogens. | G Carpenter | Annu Rev Biochem | 1987 | 3039909 | No |
| 2243 | 1290 | 1290.0 | 34.2 | 34.2 | Phylogenies from molecular sequences: inference and reliability. | J Felsenstein | Annu Rev Genet | 1988 | 3071258 | No |
| 2244 | 3870 | 1290.0 | 95.58 | 31.9 | Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. | Daniel Falush, Matthew Stephens, Jonathan K Pritchard | Genetics | 2003 | 12930761 | Yes |
| 2245 | 1290 | 1290.0 | 23.15 | 23.1 | Protein modification by SUMO. | Erica S Johnson | Annu Rev Biochem | 2004 | 15189146 | No |
| 2246 | 2578 | 1289.0 | 0.0 | 0.0 | Functions of lysosomes. | C De Duve, R Wattiaux | Annu Rev Physiol | 1966 | 5322983 | No |
| 2247 | 1289 | 1289.0 | 41.94 | 41.9 | Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. | Thomas Heberer | Toxicol Lett | 2002 | 11988354 | Yes |
| 2248 | 2577 | 1288.5 | 0.0 | 0.0 | Glutathione peroxidase activity in selenium-deficient rat liver. | R A Lawrence, R F Burk | Biochem Biophys Res Commun | 1976 | 971321 | Yes |
| 2249 | 2577 | 1288.5 | 69.04 | 34.5 | Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. | S Schulman, C Kearon | J Thromb Haemost | 2005 | 15842354 | Yes |
| 2250 | 3864 | 1288.0 | 80.72 | 26.9 | The versatility and universality of calcium signalling. | M J Berridge, P Lipp, M D Bootman | Nat Rev Mol Cell Biol | 2000 | 11413485 | No |
| 2251 | 3863 | 1287.7 | 106.33 | 35.4 | TCS: a computer program to estimate gene genealogies. | M Clement, D Posada, K A Crandall | Mol Ecol | 2000 | 11050560 | Yes |
| 2252 | 2575 | 1287.5 | 0.0 | 0.0 | A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. | B G Durie, S E Salmon | Cancer | 1975 | 1182674 | Yes |
| 2253 | 2574 | 1287.0 | 0.0 | 0.0 | Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. | J A Ledbetter, L A Herzenberg | Immunol Rev | 1979 | 398327 | No |
| 2254 | 2574 | 1287.0 | 48.12 | 24.1 | New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. | R D Gietz, A Sugino | Gene | 1988 | 3073106 | Yes |
| 2255 | 1287 | 1287.0 | 68.68 | 68.7 | The determinants of parenting: a process model. | J Belsky | Child Dev | 1984 | 6705636 | Yes |
| 2256 | 1287 | 1287.0 | 34.04 | 34.0 | The aryl hydrocarbon receptor complex. | O Hankinson | Annu Rev Pharmacol Toxicol | 1995 | 7598497 | No |
| 2257 | 2574 | 1287.0 | 53.49 | 26.7 | Short-term synaptic plasticity. | Robert S Zucker, Wade G Regehr | Annu Rev Physiol | 2002 | 11826273 | No |
| 2258 | 1287 | 1287.0 | 28.11 | 28.1 | Stability and flexibility of epigenetic gene regulation in mammalian development. | Wolf Reik | Nature | 2007 | 17522676 | No |
| 2259 | 1287 | 1287.0 | 46.78 | 46.8 | Inflammation in atherosclerosis. | Peter Libby | Arterioscler Thromb Vasc Biol | 2012 | 22895665 | No |
| 2260 | 1286 | 1286.0 | 0.0 | 0.0 | Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. | J H Luft | Anat Rec | 1971 | 4108333 | Yes |
| 2261 | 1286 | 1286.0 | 35.62 | 35.6 | Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. | P Lips | Endocr Rev | 2001 | 11493580 | No |
| 2262 | 1286 | 1286.0 | 46.41 | 46.4 | Phase retrieval algorithms: a comparison. | J R Fienup | Appl Opt | 1982 | 20396114 | Yes |
| 2263 | 2572 | 1286.0 | 77.42 | 38.7 | miRBase: integrating microRNA annotation and deep-sequencing data. | Ana Kozomara, Sam Griffiths-Jones | Nucleic Acids Res | 2011 | 21037258 | Yes |
| 2264 | 2571 | 1285.5 | 85.05 | 42.5 | The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. | W R Gibb, A J Lees | J Neurol Neurosurg Psychiatry | 1988 | 2841426 | No |
| 2265 | 2571 | 1285.5 | 58.17 | 29.1 | Escaping free-energy minima. | Alessandro Laio, Michele Parrinello | Proc Natl Acad Sci U S A | 2002 | 12271136 | Yes |
| 2266 | 2571 | 1285.5 | 86.25 | 43.1 | Oxidative stress and diabetic complications. | Ferdinando Giacco, Michael Brownlee | Circ Res | 2010 | 21030723 | No |
| 2267 | 3856 | 1285.3 | 85.03 | 28.3 | Multidrug resistance in cancer: role of ATP-dependent transporters. | Michael M Gottesman, Tito Fojo, Susan E Bates | Nat Rev Cancer | 2002 | 11902585 | No |
| 2268 | 1285 | 1285.0 | 41.33 | 41.3 | The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. | J L Cummings | Neurology | 1997 | 9153155 | No |
| 2269 | 2568 | 1284.0 | 0.0 | 0.0 | Regulatory sequences involved in the promotion and termination of RNA transcription. | M Rosenberg, D Court | Annu Rev Genet | 1979 | 94251 | No |
| 2270 | 1283 | 1283.0 | 0.0 | 0.0 | Cardiovascular and renal actions of dopamine: potential clinical applications. | L I Goldberg | Pharmacol Rev | 1972 | 4554480 | No |
| 2271 | 1283 | 1283.0 | 0.0 | 0.0 | The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. | R G Khalifah | J Biol Chem | 1971 | 4994926 | Yes |
| 2272 | 1283 | 1283.0 | 30.74 | 30.7 | Lymphokine production by human T cells in disease states. | S Romagnani | Annu Rev Immunol | 1994 | 8011282 | No |
| 2273 | 1283 | 1283.0 | 46.3 | 46.3 | Multimodal approach to control postoperative pathophysiology and rehabilitation. | H Kehlet | Br J Anaesth | 1997 | 9175983 | No |
| 2274 | 2565 | 1282.5 | 0.0 | 0.0 | The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. | J Shine, L Dalgarno | Proc Natl Acad Sci U S A | 1974 | 4598299 | Yes |
| 2275 | 2565 | 1282.5 | 43.55 | 21.8 | Genetic transformation of Drosophila with transposable element vectors. | G M Rubin, A C Spradling | Science | 1982 | 6289436 | Yes |
| 2276 | 2565 | 1282.5 | 69.48 | 34.7 | ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. | Markus Wiederstein, Manfred J Sippl | Nucleic Acids Res | 2007 | 17517781 | Yes |
| 2277 | 1282 | 1282.0 | 0.0 | 0.0 | The intraclass correlation coefficient as a measure of reliability. | J J Bartko | Psychol Rep | 1966 | 5942109 | Yes |
| 2278 | 1282 | 1282.0 | 22.81 | 22.8 | Clonal selection and learning in the antibody system. | K Rajewsky | Nature | 1996 | 8657279 | No |
| 2279 | 1282 | 1282.0 | 29.35 | 29.4 | Topoisomerase I inhibitors: camptothecins and beyond. | Yves Pommier | Nat Rev Cancer | 2006 | 16990856 | No |
| 2280 | 1281 | 1281.0 | 0.0 | 0.0 | Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. | A Böyum | Scand J Clin Lab Invest Suppl | 1968 | 4179066 | Yes |
| 2281 | 2562 | 1281.0 | 55.23 | 27.6 | Liver regeneration. | G K Michalopoulos, M C DeFrances | Science | 1997 | 9082986 | No |
| 2282 | 1281 | 1281.0 | 34.18 | 34.2 | Reconciling the chemistry and biology of reactive oxygen species. | Christine C Winterbourn | Nat Chem Biol | 2008 | 18421291 | No |
| 2283 | 7682 | 1280.3 | 207.34 | 34.6 | Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. | Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur Wheeler | N Engl J Med | 2000 | 10793162 | Yes |
| 2284 | 1280 | 1280.0 | 46.8 | 46.8 | Substance P. | B Pernow | Pharmacol Rev | 1983 | 6196797 | No |
| 2285 | 1280 | 1280.0 | 33.77 | 33.8 | Supported membranes: scientific and practical applications. | E Sackmann | Science | 1996 | 8539599 | No |
| 2286 | 1280 | 1280.0 | 0.0 | 0.0 | Diversity in tropical rain forests and coral reefs. | J H Connell | Science | 1978 | 17840770 | Yes |
| 2287 | 1279 | 1279.0 | 0.0 | 0.0 | Electrophoretic separation of plasma lipoproteins in agarose gel. | R P Noble | J Lipid Res | 1968 | 4176473 | Yes |
| 2288 | 3836 | 1278.7 | 96.31 | 32.1 | Long non-coding RNAs: insights into functions. | Tim R Mercer, Marcel E Dinger, John S Mattick | Nat Rev Genet | 2009 | 19188922 | No |
| 2289 | 1277 | 1277.0 | 31.83 | 31.8 | The 'effective number of codons' used in a gene. | F Wright | Gene | 1990 | 2110097 | Yes |
| 2290 | 1277 | 1277.0 | 38.98 | 39.0 | Diversity and ubiquity of K channels. | B Rudy | Neuroscience | 1988 | 2457185 | No |
| 2291 | 1277 | 1277.0 | 32.2 | 32.2 | Fast and robust fixed-point algorithms for independent component analysis. | A Hyvärinen | IEEE Trans Neural Netw | 1999 | 18252563 | Yes |
| 2292 | 1277 | 1277.0 | 58.42 | 58.4 | Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement. | Virginia A Moyer | Ann Intern Med | 2014 | 24378917 | No |
| 2293 | 1276 | 1276.0 | 46.38 | 46.4 | The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. | A Raine | Schizophr Bull | 1991 | 1805349 | Yes |
| 2294 | 1276 | 1276.0 | 48.09 | 48.1 | The life and times of the Enterococcus. | B E Murray | Clin Microbiol Rev | 1990 | 2404568 | No |
| 2295 | 6379 | 1275.8 | 194.25 | 38.9 | Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. | Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E Walters | Arch Gen Psychiatry | 2005 | 15939839 | Yes |
| 2296 | 2551 | 1275.5 | 76.73 | 38.4 | The Measurement Of Selection On Correlated Characters. | Russell Lande, Stevan J Arnold | Evolution | 1983 | 28556011 | Yes |
| 2297 | 1275 | 1275.0 | 0.0 | 0.0 | Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. | H M Kalckar | J Biol Chem | 1947 | 20285041 | Yes |
| 2298 | 2549 | 1274.5 | 56.56 | 28.3 | LTP and LTD: an embarrassment of riches. | Robert C Malenka, Mark F Bear | Neuron | 2004 | 15450156 | No |
| 2299 | 1274 | 1274.0 | 36.43 | 36.4 | Stress and depression. | Constance Hammen | Annu Rev Clin Psychol | 2005 | 17716090 | No |
| 2300 | 2547 | 1273.5 | 0.0 | 0.0 | Prediction of the secondary structure of proteins from their amino acid sequence. | P Y Chou, G D Fasman | Adv Enzymol Relat Areas Mol Biol | 1978 | 364941 | No |
| 2301 | 2547 | 1273.5 | 62.4 | 31.2 | Multipoint quantitative-trait linkage analysis in general pedigrees. | L Almasy, J Blangero | Am J Hum Genet | 1998 | 9545414 | Yes |
| 2302 | 1273 | 1273.0 | 41.83 | 41.8 | Somatostatin. | S Reichlin | N Engl J Med | 1983 | 6139753 | No |
| 2303 | 2545 | 1272.5 | 0.0 | 0.0 | Establishment and characterization of a human histiocytic lymphoma cell line (U-937). | C Sundström, K Nilsson | Int J Cancer | 1976 | 178611 | Yes |
| 2304 | 1272 | 1272.0 | 38.47 | 38.5 | Osteoblast adhesion on biomaterials. | K Anselme | Biomaterials | 2000 | 10711964 | No |
| 2305 | 1272 | 1272.0 | 35.55 | 35.5 | Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. | E B Hunziker | Osteoarthritis Cartilage | 2002 | 12056848 | No |
| 2306 | 1272 | 1272.0 | 31.93 | 31.9 | The blood-brain barrier: bottleneck in brain drug development. | William M Pardridge | NeuroRx | 2005 | 15717053 | No |
| 2307 | 6359 | 1271.8 | 243.03 | 48.6 | Evidence based medicine: what it is and what it isn't. | D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S Richardson | BMJ | 1996 | 8555924 | No |
| 2308 | 3815 | 1271.7 | 136.69 | 45.6 | Global estimates of the prevalence of diabetes for 2010 and 2030. | J E Shaw, R A Sicree, P Z Zimmet | Diabetes Res Clin Pract | 2010 | 19896746 | Yes |
| 2309 | 1270 | 1270.0 | 26.96 | 27.0 | The many faces of macrophage activation. | David M Mosser | J Leukoc Biol | 2003 | 12554797 | No |
| 2310 | 3808 | 1269.3 | 82.86 | 27.6 | A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. | R Medzhitov, P Preston-Hurlburt, C A Janeway | Nature | 1997 | 9237759 | Yes |
| 2311 | 1269 | 1269.0 | 27.75 | 27.8 | Codon usage and tRNA content in unicellular and multicellular organisms. | T Ikemura | Mol Biol Evol | 1985 | 3916708 | No |
| 2312 | 2538 | 1269.0 | 79.05 | 39.5 | The cortical organization of speech processing. | Gregory Hickok, David Poeppel | Nat Rev Neurosci | 2007 | 17431404 | No |
| 2313 | 2538 | 1269.0 | 70.92 | 35.5 | Molecular replacement with MOLREP. | Alexei Vagin, Alexei Teplyakov | Acta Crystallogr D Biol Crystallogr | 2010 | 20057045 | Yes |
| 2314 | 1268 | 1268.0 | 0.0 | 0.0 | The origin of the genetic code. | F H Crick | J Mol Biol | 1968 | 4887876 | Yes |
| 2315 | 1268 | 1268.0 | 27.8 | 27.8 | HIF-1: mediator of physiological and pathophysiological responses to hypoxia. | G L Semenza | J Appl Physiol (1985) | 2000 | 10749844 | No |
| 2316 | 2536 | 1268.0 | 91.38 | 45.7 | How useful is SBF in predicting in vivo bone bioactivity? | Tadashi Kokubo, Hiroaki Takadama | Biomaterials | 2006 | 16448693 | No |
| 2317 | 2535 | 1267.5 | 65.38 | 32.7 | Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. | M P Lutolf, J A Hubbell | Nat Biotechnol | 2005 | 15637621 | No |
| 2318 | 2534 | 1267.0 | 0.0 | 0.0 | A rapid, sensitive, and specific method for the determination of protein in dilute solution. | W Schaffner, C Weissmann | Anal Biochem | 1973 | 4128882 | Yes |
| 2319 | 2534 | 1267.0 | 49.81 | 24.9 | Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. | M Fried, D M Crothers | Nucleic Acids Res | 1981 | 6275366 | Yes |
| 2320 | 1267 | 1267.0 | 37.14 | 37.1 | Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. | P Willner | Psychopharmacology (Berl) | 1997 | 9452163 | No |
| 2321 | 1267 | 1267.0 | 33.07 | 33.1 | Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. | R M Sapolsky | Arch Gen Psychiatry | 2000 | 11015810 | No |
| 2322 | 2534 | 1267.0 | 52.16 | 26.1 | An automated method for finding molecular complexes in large protein interaction networks. | Gary D Bader, Christopher W V Hogue | BMC Bioinformatics | 2003 | 12525261 | Yes |
| 2323 | 7602 | 1267.0 | 190.31 | 31.7 | GROMACS: fast, flexible, and free. | David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C Berendsen | J Comput Chem | 2005 | 16211538 | Yes |
| 2324 | 2534 | 1267.0 | 100.81 | 50.4 | PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. | Daniel R Roe, Thomas E Cheatham | J Chem Theory Comput | 2013 | 26583988 | Yes |
| 2325 | 1266 | 1266.0 | 29.19 | 29.2 | Chemistry and biology of the immunophilins and their immunosuppressive ligands. | S L Schreiber | Science | 1991 | 1702904 | No |
| 2326 | 1266 | 1266.0 | 54.55 | 54.5 | MorphoJ: an integrated software package for geometric morphometrics. | Christian Peter Klingenberg | Mol Ecol Resour | 2011 | 21429143 | Yes |
| 2327 | 1265 | 1265.0 | 45.1 | 45.1 | Carnitine--metabolism and functions. | J Bremer | Physiol Rev | 1983 | 6361812 | No |
| 2328 | 1265 | 1265.0 | 52.63 | 52.6 | Error in medicine. | L L Leape | JAMA | 1994 | 7503827 | Yes |
| 2329 | 6322 | 1264.4 | 0.0 | 0.0 | Enzymatic determination of total serum cholesterol. | C C Allain, L S Poon, C S Chan, W Richmond, P C Fu | Clin Chem | 1974 | 4818200 | Yes |
| 2330 | 1264 | 1264.0 | 0.0 | 0.0 | Structure and function of intercellular junctions. | L A Staehelin | Int Rev Cytol | 1974 | 4611943 | No |
| 2331 | 1264 | 1264.0 | 30.44 | 30.4 | Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? | Rui Wang | FASEB J | 2002 | 12409322 | Yes |
| 2332 | 2527 | 1263.5 | 112.21 | 56.1 | Natural products as sources of new drugs over the 30 years from 1981 to 2010. | David J Newman, Gordon M Cragg | J Nat Prod | 2012 | 22316239 | No |
| 2333 | 1263 | 1263.0 | 0.0 | 0.0 | Disconnexion syndromes in animals and man. I. | N Geschwind | Brain | 1965 | 5318481 | No |
| 2334 | 1263 | 1263.0 | 0.0 | 0.0 | Limitations of the application of fourfold table analysis to hospital data. | J Berkson | Biometrics | 1946 | 21001024 | Yes |
| 2335 | 2525 | 1262.5 | 66.88 | 33.4 | A globally coherent fingerprint of climate change impacts across natural systems. | Camille Parmesan, Gary Yohe | Nature | 2003 | 12511946 | Yes |
| 2336 | 1261 | 1261.0 | 0.0 | 0.0 | The biologic clock: the mitochondria? | D Harman | J Am Geriatr Soc | 1972 | 5016631 | Yes |
| 2337 | 1261 | 1261.0 | 26.32 | 26.3 | Signal transduction via the MAP kinases: proceed at your own RSK. | J Blenis | Proc Natl Acad Sci U S A | 1993 | 8392180 | No |
| 2338 | 2522 | 1261.0 | 46.24 | 23.1 | Rab proteins as membrane organizers. | M Zerial, H McBride | Nat Rev Mol Cell Biol | 2001 | 11252952 | No |
| 2339 | 1261 | 1261.0 | 41.75 | 41.8 | Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. | Chao-Jun Li | Acc Chem Res | 2009 | 19220064 | Yes |
| 2340 | 1261 | 1261.0 | 77.74 | 77.7 | Abiotic Stress Signaling and Responses in Plants. | Jian-Kang Zhu | Cell | 2016 | 27716505 | No |
| 2341 | 1261 | 1261.0 | 122.93 | 122.9 | Hepatocellular Carcinoma. | Augusto Villanueva | N Engl J Med | 2019 | 30970190 | No |
| 2342 | 2521 | 1260.5 | 75.03 | 37.5 | Epidemiology of invasive candidiasis: a persistent public health problem. | M A Pfaller, D J Diekema | Clin Microbiol Rev | 2007 | 17223626 | No |
| 2343 | 7558 | 1259.7 | 189.34 | 31.6 | Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. | Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O Lötvall | Nat Cell Biol | 2007 | 17486113 | Yes |
| 2344 | 2519 | 1259.5 | 55.9 | 27.9 | Mitochondrial control of cell death. | G Kroemer, J C Reed | Nat Med | 2000 | 10802706 | No |
| 2345 | 2518 | 1259.0 | 55.8 | 27.9 | Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. | M Zuker, P Stiegler | Nucleic Acids Res | 1981 | 6163133 | Yes |
| 2346 | 1259 | 1259.0 | 26.14 | 26.1 | SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. | S V Evans | J Mol Graph | 1993 | 8347566 | Yes |
| 2347 | 1259 | 1259.0 | 23.38 | 23.4 | c-Myc target genes involved in cell growth, apoptosis, and metabolism. | C V Dang | Mol Cell Biol | 1999 | 9858526 | No |
| 2348 | 1259 | 1259.0 | 22.33 | 22.3 | The economics of ribosome biosynthesis in yeast. | J R Warner | Trends Biochem Sci | 1999 | 10542411 | No |
| 2349 | 2518 | 1259.0 | 65.05 | 32.5 | The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. | Clay B Holroyd, Michael G H Coles | Psychol Rev | 2002 | 12374324 | Yes |
| 2350 | 1259 | 1259.0 | 0.0 | 0.0 | The critical incident technique. | J C Flanagan | Psychol Bull | 1954 | 13177800 | Yes |
| 2351 | 1259 | 1259.0 | 34.4 | 34.4 | Genetic consequences of climatic oscillations in the Quaternary. | G M Hewitt | Philos Trans R Soc Lond B Biol Sci | 2004 | 15101575 | No |
| 2352 | 1258 | 1258.0 | 0.0 | 0.0 | Strategy and tactics in protein chemistry. | B S Hartley | Biochem J | 1970 | 4923920 | No |
| 2353 | 1258 | 1258.0 | 51.14 | 51.1 | An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. | J Kabat-Zinn | Gen Hosp Psychiatry | 1982 | 7042457 | Yes |
| 2354 | 2516 | 1258.0 | 50.52 | 25.3 | Prediction of complete gene structures in human genomic DNA. | C Burge, S Karlin | J Mol Biol | 1997 | 9149143 | Yes |
| 2355 | 2515 | 1257.5 | 66.2 | 33.1 | Apoptosis, oncosis, and necrosis. An overview of cell death. | G Majno, I Joris | Am J Pathol | 1995 | 7856735 | No |
| 2356 | 1257 | 1257.0 | 25.85 | 25.9 | Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. | R H Schwartz | Cell | 1992 | 1335362 | No |
| 2357 | 1257 | 1257.0 | 34.02 | 34.0 | Signaling through phosphatidylcholine breakdown. | J H Exton | J Biol Chem | 1990 | 2104616 | No |
| 2358 | 2514 | 1257.0 | 78.62 | 39.3 | Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). | Kathryn M Connor, Jonathan R T Davidson | Depress Anxiety | 2003 | 12964174 | Yes |
| 2359 | 1257 | 1257.0 | 0.0 | 0.0 | A new readability yardstick. | R Flesch | J Appl Psychol | 1948 | 18867058 | Yes |
| 2360 | 2513 | 1256.5 | 65.34 | 32.7 | Powering the planet: chemical challenges in solar energy utilization. | Nathan S Lewis, Daniel G Nocera | Proc Natl Acad Sci U S A | 2006 | 17043226 | Yes |
| 2361 | 2512 | 1256.0 | 67.49 | 33.7 | Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. | J L Weber, P E May | Am J Hum Genet | 1989 | 2916582 | Yes |
| 2362 | 1256 | 1256.0 | 43.17 | 43.2 | Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. | R Lotan | Biochim Biophys Acta | 1980 | 6989400 | No |
| 2363 | 1256 | 1256.0 | 31.75 | 31.8 | Apoptosis. | J J Cohen | Immunol Today | 1993 | 8466628 | No |
| 2364 | 1256 | 1256.0 | 35.69 | 35.7 | Emotion regulation: affective, cognitive, and social consequences. | James J Gross | Psychophysiology | 2002 | 12212647 | No |
| 2365 | 2512 | 1256.0 | 97.17 | 48.6 | Neutrophil recruitment and function in health and inflammation. | Elzbieta Kolaczkowska, Paul Kubes | Nat Rev Immunol | 2013 | 23435331 | No |
| 2366 | 2511 | 1255.5 | 115.4 | 57.7 | A new initiative on precision medicine. | Francis S Collins, Harold Varmus | N Engl J Med | 2015 | 25635347 | Yes |
| 2367 | 1255 | 1255.0 | 0.0 | 0.0 | Bee and wasp venoms. | E Habermann | Science | 1972 | 4113805 | No |
| 2368 | 1255 | 1255.0 | 28.35 | 28.4 | Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. | T A Springer | Annu Rev Physiol | 1995 | 7778885 | No |
| 2369 | 2510 | 1255.0 | 83.2 | 41.6 | Quality control and preprocessing of metagenomic datasets. | Robert Schmieder, Robert Edwards | Bioinformatics | 2011 | 21278185 | Yes |
| 2370 | 5020 | 1255.0 | 216.56 | 54.1 | Bayesian phylogenetics with BEAUti and the BEAST 1.7. | Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew Rambaut | Mol Biol Evol | 2012 | 22367748 | Yes |
| 2371 | 2509 | 1254.5 | 82.76 | 41.4 | Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. | Johan W S Vlaeyen, Steven J Linton | Pain | 2000 | 10781906 | No |
| 2372 | 2509 | 1254.5 | 65.66 | 32.8 | The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. | Daniel J Drucker, Michael A Nauck | Lancet | 2006 | 17098089 | No |
| 2373 | 6272 | 1254.4 | 159.89 | 32.0 | Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. | Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory Collins | Lancet | 2002 | 12493255 | Yes |
| 2374 | 8780 | 1254.3 | 265.4 | 37.9 | Cancer statistics, 2008. | Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J Thun | CA Cancer J Clin | 2008 | 18287387 | Yes |
| 2375 | 1254 | 1254.0 | 30.48 | 30.5 | Papillomavirus infections--a major cause of human cancers. | H zur Hausen | Biochim Biophys Acta | 1996 | 8876633 | No |
| 2376 | 1254 | 1254.0 | 23.27 | 23.3 | SUMO: a history of modification. | Ronald T Hay | Mol Cell | 2005 | 15808504 | No |
| 2377 | 1253 | 1253.0 | 28.17 | 28.2 | Life, death, and the pursuit of apoptosis. | E White | Genes Dev | 1996 | 8557188 | No |
| 2378 | 1252 | 1252.0 | 30.63 | 30.6 | Short-term synaptic plasticity. | R S Zucker | Annu Rev Neurosci | 1989 | 2648947 | No |
| 2379 | 1252 | 1252.0 | 0.0 | 0.0 | A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. | A M Olovnikov | J Theor Biol | 1973 | 4754905 | Yes |
| 2380 | 1252 | 1252.0 | 37.86 | 37.9 | Circuitry and functional aspects of the insular lobe in primates including humans. | J R Augustine | Brain Res Brain Res Rev | 1996 | 8957561 | No |
| 2381 | 1252 | 1252.0 | 34.53 | 34.5 | Diagnosis of osteoporosis and assessment of fracture risk. | John A Kanis | Lancet | 2002 | 12057569 | No |
| 2382 | 2503 | 1251.5 | 58.15 | 29.1 | DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. | S Tabor, C C Richardson | Proc Natl Acad Sci U S A | 1987 | 3474623 | Yes |
| 2383 | 2502 | 1251.0 | 52.41 | 26.2 | The molecular biology of axon guidance. | M Tessier-Lavigne, C S Goodman | Science | 1996 | 8895455 | No |
| 2384 | 1251 | 1251.0 | 29.54 | 29.5 | The Unified Medical Language System (UMLS): integrating biomedical terminology. | Olivier Bodenreider | Nucleic Acids Res | 2004 | 14681409 | Yes |
| 2385 | 1251 | 1251.0 | 33.65 | 33.6 | The human orbitofrontal cortex: linking reward to hedonic experience. | Morten L Kringelbach | Nat Rev Neurosci | 2005 | 16136173 | No |
| 2386 | 1251 | 1251.0 | 0.0 | 0.0 | On the local reactions of the arterial wall to changes of internal pressure. | W M Bayliss | J Physiol | 1902 | 16992618 | Yes |
| 2387 | 2502 | 1251.0 | 76.94 | 38.5 | CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. | Mattias Jakobsson, Noah A Rosenberg | Bioinformatics | 2007 | 17485429 | Yes |
| 2388 | 2501 | 1250.5 | 90.39 | 45.2 | Total energy intake: implications for epidemiologic analyses. | W Willett, M J Stampfer | Am J Epidemiol | 1986 | 3521261 | No |
| 2389 | 1250 | 1250.0 | 20.77 | 20.8 | Antigen receptor tail clue. | M Reth | Nature | 1989 | 2927501 | Yes |
| 2390 | 1250 | 1250.0 | 25.81 | 25.8 | Searching for genetic determinants in the new millennium. | N J Risch | Nature | 2000 | 10866211 | No |
| 2391 | 1250 | 1250.0 | 0.0 | 0.0 | The effective period of preventive antibiotic action in experimental incisions and dermal lesions. | J F Burke | Surgery | 1961 | 16722001 | Yes |
| 2392 | 6249 | 1249.8 | 0.0 | 0.0 | Transection of the oesophagus for bleeding oesophageal varices. | R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R Williams | Br J Surg | 1973 | 4541913 | Yes |
| 2393 | 1249 | 1249.0 | 29.52 | 29.5 | Refined structure of the nicotinic acetylcholine receptor at 4A resolution. | Nigel Unwin | J Mol Biol | 2005 | 15701510 | Yes |
| 2394 | 8738 | 1248.3 | 316.4 | 45.2 | GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. | Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J Schünemann | BMJ | 2008 | 18436948 | Yes |
| 2395 | 3745 | 1248.3 | 113.67 | 37.9 | A rapid bootstrap algorithm for the RAxML Web servers. | Alexandros Stamatakis, Paul Hoover, Jacques Rougemont | Syst Biol | 2008 | 18853362 | Yes |
| 2396 | 2496 | 1248.0 | 57.12 | 28.6 | Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. | D A Brown, J K Rose | Cell | 1992 | 1531449 | Yes |
| 2397 | 1248 | 1248.0 | 0.0 | 0.0 | On the psychophysical law. | S S Stevens | Psychol Rev | 1957 | 13441853 | Yes |
| 2398 | 1247 | 1247.0 | 47.56 | 47.6 | The structure of beta-lactamases. | R P Ambler | Philos Trans R Soc Lond B Biol Sci | 1980 | 6109327 | Yes |
| 2399 | 1247 | 1247.0 | 41.18 | 41.2 | An application of prefrontal cortex function theory to cognitive aging. | R L West | Psychol Bull | 1996 | 8831298 | No |
| 2400 | 1246 | 1246.0 | 25.84 | 25.8 | Endocytosis and molecular sorting. | I Mellman | Annu Rev Cell Dev Biol | 1996 | 8970738 | No |
| 2401 | 1246 | 1246.0 | 47.79 | 47.8 | Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. | T Florian Jaeger | J Mem Lang | 2008 | 19884961 | Yes |
| 2402 | 8716 | 1245.1 | 281.99 | 40.3 | AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. | Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J Olson | J Comput Chem | 2009 | 19399780 | Yes |
| 2403 | 1245 | 1245.0 | 34.42 | 34.4 | The cancer stem cell: premises, promises and challenges. | Hans Clevers | Nat Med | 2011 | 21386835 | No |
| 2404 | 2490 | 1245.0 | 146.09 | 73.0 | The amyloid hypothesis of Alzheimer's disease at 25 years. | Dennis J Selkoe, John Hardy | EMBO Mol Med | 2016 | 27025652 | No |
| 2405 | 3734 | 1244.7 | 87.61 | 29.2 | Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. | Christian W Tornøe, Caspar Christensen, Morten Meldal | J Org Chem | 2002 | 11975567 | Yes |
| 2406 | 3732 | 1244.0 | 99.25 | 33.1 | Cognitive and emotional influences in anterior cingulate cortex. | Bush, Luu, Posner | Trends Cogn Sci | 2000 | 10827444 | Yes |
| 2407 | 2488 | 1244.0 | 76.05 | 38.0 | Mediation in experimental and nonexperimental studies: new procedures and recommendations. | Patrick E Shrout, Niall Bolger | Psychol Methods | 2002 | 12530702 | Yes |
| 2408 | 2488 | 1244.0 | 52.68 | 26.3 | Regulated portals of entry into the cell. | Sean D Conner, Sandra L Schmid | Nature | 2003 | 12621426 | No |
| 2409 | 13682 | 1243.8 | 475.78 | 43.3 | A new equation to estimate glomerular filtration rate. | Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef Coresh | Ann Intern Med | 2009 | 19414839 | Yes |
| 2410 | 2485 | 1242.5 | 59.03 | 29.5 | Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. | Jane E Visvader, Geoffrey J Lindeman | Nat Rev Cancer | 2008 | 18784658 | No |
| 2411 | 1242 | 1242.0 | 38.59 | 38.6 | Classification of chronic viral hepatitis: a need for reassessment. | P J Scheuer | J Hepatol | 1991 | 1808228 | No |
| 2412 | 1242 | 1242.0 | 0.0 | 0.0 | A restriction point for control of normal animal cell proliferation. | A B Pardee | Proc Natl Acad Sci U S A | 1974 | 4524638 | Yes |
| 2413 | 1242 | 1242.0 | 56.7 | 56.7 | Derivation and validation of a short-form oral health impact profile. | G D Slade | Community Dent Oral Epidemiol | 1997 | 9332805 | Yes |
| 2414 | 1242 | 1242.0 | 29.31 | 29.3 | DNA damage, aging, and cancer. | Jan H J Hoeijmakers | N Engl J Med | 2009 | 19812404 | No |
| 2415 | 9932 | 1241.5 | 256.34 | 32.0 | Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. | N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M Joliot | Neuroimage | 2002 | 11771995 | Yes |
| 2416 | 2482 | 1241.0 | 73.09 | 36.5 | Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. | J I Morgan, T Curran | Annu Rev Neurosci | 1991 | 1903243 | No |
| 2417 | 3723 | 1241.0 | 98.13 | 32.7 | Membrane lipids: where they are and how they behave. | Gerrit van Meer, Dennis R Voelker, Gerald W Feigenson | Nat Rev Mol Cell Biol | 2008 | 18216768 | No |
| 2418 | 6202 | 1240.4 | 150.94 | 30.2 | Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. | T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L Coffman | J Immunol | 1986 | 2419430 | Yes |
| 2419 | 1240 | 1240.0 | 0.0 | 0.0 | The anterior approach for removal of ruptured cervical disks. | R B Cloward | J Neurosurg | 1958 | 13599052 | Yes |
| 2420 | 2479 | 1239.5 | 62.89 | 31.4 | Interneurons of the hippocampus. | T F Freund, G Buzsáki | Hippocampus | 1996 | 8915675 | No |
| 2421 | 2479 | 1239.5 | 0.0 | 0.0 | Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. | G J Todaro, H Green | J Cell Biol | 1963 | 13985244 | Yes |
| 2422 | 8676 | 1239.4 | 360.55 | 51.5 | Development and validation of a geriatric depression screening scale: a preliminary report. | J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O Leirer | J Psychiatr Res | 1982 | 7183759 | Yes |
| 2423 | 1239 | 1239.0 | 43.59 | 43.6 | The theoretical bases of indirect calorimetry: a review. | E Ferrannini | Metabolism | 1988 | 3278194 | No |
| 2424 | 1239 | 1239.0 | 42.46 | 42.5 | How is the level of free arachidonic acid controlled in mammalian cells? | R F Irvine | Biochem J | 1982 | 6810878 | No |
| 2425 | 1239 | 1239.0 | 24.52 | 24.5 | microRNAs: tiny regulators with great potential. | V Ambros | Cell | 2001 | 11779458 | No |
| 2426 | 1239 | 1239.0 | 0.0 | 0.0 | A modification of receptor theory. | R P Stephenson | Br J Pharmacol Chemother | 1956 | 13383117 | Yes |
| 2427 | 2476 | 1238.0 | 0.0 | 0.0 | Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. | J M Tanner, R H Whitehouse | Arch Dis Child | 1976 | 952550 | Yes |
| 2428 | 1238 | 1238.0 | 24.87 | 24.9 | STATs: signal transducers and activators of transcription. | J N Ihle | Cell | 1996 | 8608586 | No |
| 2429 | 1238 | 1238.0 | 0.0 | 0.0 | Sequential tests for the detection of linkage. | N E Morton | Am J Hum Genet | 1955 | 13258560 | Yes |
| 2430 | 1238 | 1238.0 | 35.6 | 35.6 | Atopic dermatitis. | Thomas Bieber | N Engl J Med | 2008 | 18385500 | Yes |
| 2431 | 2476 | 1238.0 | 99.39 | 49.7 | Van der Waals heterostructures. | A K Geim, I V Grigorieva | Nature | 2013 | 23887427 | Yes |
| 2432 | 1237 | 1237.0 | 34.98 | 35.0 | Tumor angiogenesis. | J Folkman | Adv Cancer Res | 1985 | 2581424 | No |
| 2433 | 1237 | 1237.0 | 55.71 | 55.7 | Human agency in social cognitive theory. | A Bandura | Am Psychol | 1989 | 2782727 | Yes |
| 2434 | 2474 | 1237.0 | 91.07 | 45.5 | The stunned myocardium: prolonged, postischemic ventricular dysfunction. | E Braunwald, R A Kloner | Circulation | 1982 | 6754130 | No |
| 2435 | 1237 | 1237.0 | 31.23 | 31.2 | Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. | J Deisenhofer | Biochemistry | 1981 | 7236608 | Yes |
| 2436 | 1237 | 1237.0 | 28.26 | 28.3 | Physiological and molecular basis of thyroid hormone action. | P M Yen | Physiol Rev | 2001 | 11427693 | No |
| 2437 | 3711 | 1237.0 | 89.79 | 29.9 | Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? | Witold Filipowicz, Suvendra N Bhattacharyya, Nahum Sonenberg | Nat Rev Genet | 2008 | 18197166 | No |
| 2438 | 2473 | 1236.5 | 0.0 | 0.0 | The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. | B N Ames, D T Dubin | J Biol Chem | 1960 | 13793161 | Yes |
| 2439 | 2471 | 1235.5 | 0.0 | 0.0 | Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. | A Fabiato, F Fabiato | J Physiol (Paris) | 1979 | 533865 | Yes |
| 2440 | 2471 | 1235.5 | 70.51 | 35.3 | Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. | Robert E W Hancock, Hans-Georg Sahl | Nat Biotechnol | 2006 | 17160061 | No |
| 2441 | 1235 | 1235.0 | 29.06 | 29.1 | Oxyradicals and DNA damage. | L J Marnett | Carcinogenesis | 2000 | 10688856 | No |
| 2442 | 2468 | 1234.0 | 61.94 | 31.0 | Pharmacology and functions of metabotropic glutamate receptors. | P J Conn, J P Pin | Annu Rev Pharmacol Toxicol | 1997 | 9131252 | No |
| 2443 | 7404 | 1234.0 | 192.5 | 32.1 | A default mode of brain function. | M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L Shulman | Proc Natl Acad Sci U S A | 2001 | 11209064 | Yes |
| 2444 | 1234 | 1234.0 | 24.76 | 24.8 | Mechanisms of caspase activation and inhibition during apoptosis. | Yigong Shi | Mol Cell | 2002 | 11931755 | No |
| 2445 | 2467 | 1233.5 | 76.85 | 38.4 | Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. | D Filmer, L H Pritchett | Demography | 2001 | 11227840 | Yes |
| 2446 | 13569 | 1233.5 | 381.5 | 34.7 | The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. | Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J Roccella | JAMA | 2003 | 12748199 | No |
| 2447 | 3700 | 1233.3 | 168.16 | 56.1 | In search of how people change. Applications to addictive behaviors. | J O Prochaska, C C DiClemente, J C Norcross | Am Psychol | 1992 | 1329589 | Yes |
| 2448 | 1233 | 1233.0 | 0.0 | 0.0 | Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. | W D Hamilton | Science | 1967 | 6021675 | Yes |
| 2449 | 1233 | 1233.0 | 60.3 | 60.3 | New norms of upper limb fat and muscle areas for assessment of nutritional status. | A R Frisancho | Am J Clin Nutr | 1981 | 6975564 | Yes |
| 2450 | 2466 | 1233.0 | 80.14 | 40.1 | Oxidative mechanisms in the toxicity of metal ions. | S J Stohs, D Bagchi | Free Radic Biol Med | 1995 | 7744317 | No |
| 2451 | 1233 | 1233.0 | 37.85 | 37.9 | Depression in late life: review and commentary. | Dan G Blazer | J Gerontol A Biol Sci Med Sci | 2003 | 12634292 | No |
| 2452 | 1232 | 1232.0 | 31.78 | 31.8 | The mitochondrial electron transport and oxidative phosphorylation system. | Y Hatefi | Annu Rev Biochem | 1985 | 2862839 | No |
| 2453 | 1232 | 1232.0 | 37.23 | 37.2 | Qinghaosu (artemisinin): an antimalarial drug from China. | D L Klayman | Science | 1985 | 3887571 | No |
| 2454 | 1232 | 1232.0 | 35.13 | 35.1 | Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. | Arnold I Caplan | J Cell Physiol | 2007 | 17620285 | No |
| 2455 | 2463 | 1231.5 | 70.19 | 35.1 | The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. | W L Jorgensen, J Tirado-Rives | J Am Chem Soc | 1988 | 27557051 | Yes |
| 2456 | 3693 | 1231.0 | 132.34 | 44.1 | A new method for off-line removal of ocular artifact. | G Gratton, M G Coles, E Donchin | Electroencephalogr Clin Neurophysiol | 1983 | 6187540 | Yes |
| 2457 | 1231 | 1231.0 | 28.05 | 28.1 | Diarylethenes for Memories and Switches. | Masahiro Irie | Chem Rev | 2000 | 11777416 | Yes |
| 2458 | 2461 | 1230.5 | 63.65 | 31.8 | Genetic dissection of complex traits. | E S Lander, N J Schork | Science | 1994 | 8091226 | No |
| 2459 | 1230 | 1230.0 | 0.0 | 0.0 | Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. | P Rakic | J Comp Neurol | 1971 | 4101340 | Yes |
| 2460 | 2460 | 1230.0 | 0.0 | 0.0 | Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. | H A Edmondson, P E Steiner | Cancer | 1954 | 13160935 | Yes |
| 2461 | 2460 | 1230.0 | 65.65 | 32.8 | Therapeutic potential of resveratrol: the in vivo evidence. | Joseph A Baur, David A Sinclair | Nat Rev Drug Discov | 2006 | 16732220 | No |
| 2462 | 1230 | 1230.0 | 28.83 | 28.8 | Mechanisms of foxp3+ T regulatory cell-mediated suppression. | Ethan M Shevach | Immunity | 2009 | 19464986 | No |
| 2463 | 2459 | 1229.5 | 99.78 | 49.9 | The future of immune checkpoint therapy. | Padmanee Sharma, James P Allison | Science | 2015 | 25838373 | No |
| 2464 | 2458 | 1229.0 | 0.0 | 0.0 | Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. | J E Sulston, H R Horvitz | Dev Biol | 1977 | 838129 | Yes |
| 2465 | 1229 | 1229.0 | 39.84 | 39.8 | The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. | Artemis P Simopoulos | Exp Biol Med (Maywood) | 2008 | 18408140 | No |
| 2466 | 1228 | 1228.0 | 31.76 | 31.8 | Rapid evolution of a protein in vitro by DNA shuffling. | W P Stemmer | Nature | 1994 | 8047147 | Yes |
| 2467 | 1228 | 1228.0 | 34.75 | 34.8 | Polycystic ovary syndrome. | David A Ehrmann | N Engl J Med | 2005 | 15788499 | No |
| 2468 | 3681 | 1227.0 | 151.41 | 50.5 | Multiple imputation using chained equations: Issues and guidance for practice. | Ian R White, Patrick Royston, Angela M Wood | Stat Med | 2011 | 21225900 | Yes |
| 2469 | 2454 | 1227.0 | 136.03 | 68.0 | mTOR Signaling in Growth, Metabolism, and Disease. | Robert A Saxton, David M Sabatini | Cell | 2017 | 28283069 | No |
| 2470 | 2453 | 1226.5 | 62.28 | 31.1 | The free radical theory of aging matures. | K B Beckman, B N Ames | Physiol Rev | 1998 | 9562038 | No |
| 2471 | 2453 | 1226.5 | 46.29 | 23.1 | Live or let die: the cell's response to p53. | Karen H Vousden, Xin Lu | Nat Rev Cancer | 2002 | 12154352 | No |
| 2472 | 1226 | 1226.0 | 67.38 | 67.4 | Psychosocial resilience and protective mechanisms. | Michael Rutter | Am J Orthopsychiatry | 1987 | 3303954 | No |
| 2473 | 1226 | 1226.0 | 37.64 | 37.6 | Calcium channel modulation by neurotransmitters, enzymes and drugs. | H Reuter | Nature | 1983 | 6131381 | No |
| 2474 | 1226 | 1226.0 | 22.47 | 22.5 | Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. | H E Ruley | Nature | 1983 | 6308473 | Yes |
| 2475 | 3677 | 1225.7 | 778.51 | 259.5 | An interactive web-based dashboard to track COVID-19 in real time. | Ensheng Dong, Hongru Du, Lauren Gardner | Lancet Infect Dis | 2020 | 32087114 | Yes |
| 2476 | 1225 | 1225.0 | 35.62 | 35.6 | Peptide antibiotics and their role in innate immunity. | H G Boman | Annu Rev Immunol | 1995 | 7612236 | No |
| 2477 | 2450 | 1225.0 | 47.15 | 23.6 | Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. | C Li, W H Wong | Proc Natl Acad Sci U S A | 2001 | 11134512 | Yes |
| 2478 | 4899 | 1224.8 | 114.3 | 28.6 | Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. | Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J Thun | N Engl J Med | 2003 | 12711737 | Yes |
| 2479 | 2448 | 1224.0 | 68.25 | 34.1 | Nitric oxide synthases: roles, tolls, and controls. | C Nathan, Q W Xie | Cell | 1994 | 7522969 | No |
| 2480 | 2448 | 1224.0 | 61.51 | 30.8 | Molecular mechanisms of action of steroid/thyroid receptor superfamily members. | M J Tsai, B W O'Malley | Annu Rev Biochem | 1994 | 7979245 | No |
| 2481 | 1224 | 1224.0 | 24.57 | 24.6 | Cytokines induce the development of functionally heterogeneous T helper cell subsets. | A O'Garra | Immunity | 1998 | 9529145 | No |
| 2482 | 1224 | 1224.0 | 33.65 | 33.6 | Microbial influences in inflammatory bowel diseases. | R Balfour Sartor | Gastroenterology | 2008 | 18242222 | No |
| 2483 | 4895 | 1223.8 | 143.99 | 36.0 | Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. | N Weidner, J P Semple, W R Welch, J Folkman | N Engl J Med | 1991 | 1701519 | Yes |
| 2484 | 2446 | 1223.0 | 75.14 | 37.6 | An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. | Sun Ho Kim, Jin Mo Chung | Pain | 1992 | 1333581 | Yes |
| 2485 | 2445 | 1222.5 | 0.0 | 0.0 | Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. | G K McMaster, G G Carmichael | Proc Natl Acad Sci U S A | 1977 | 73185 | Yes |
| 2486 | 1222 | 1222.0 | 0.0 | 0.0 | Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. | P O Seglen | Exp Cell Res | 1973 | 4358115 | Yes |
| 2487 | 3666 | 1222.0 | 84.9 | 28.3 | OrthoMCL: identification of ortholog groups for eukaryotic genomes. | Li Li, Christian J Stoeckert, David S Roos | Genome Res | 2003 | 12952885 | Yes |
| 2488 | 3663 | 1221.0 | 127.24 | 42.4 | Factor structure of the Barratt impulsiveness scale. | J H Patton, M S Stanford, E S Barratt | J Clin Psychol | 1995 | 8778124 | Yes |
| 2489 | 1221 | 1221.0 | 91.9 | 91.9 | Understanding Bland Altman analysis. | Davide Giavarina | Biochem Med (Zagreb) | 2015 | 26110027 | No |
| 2490 | 2441 | 1220.5 | 0.0 | 0.0 | Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. | J Altman, G D Das | J Comp Neurol | 1965 | 5861717 | Yes |
| 2491 | 2441 | 1220.5 | 44.29 | 22.1 | The DNA damage response: putting checkpoints in perspective. | B B Zhou, S J Elledge | Nature | 2000 | 11100718 | No |
| 2492 | 1220 | 1220.0 | 45.95 | 46.0 | Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. | S Katz | J Am Geriatr Soc | 1983 | 6418786 | No |
| 2493 | 2440 | 1220.0 | 69.14 | 34.6 | What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? | K C Berridge, T E Robinson | Brain Res Brain Res Rev | 1998 | 9858756 | No |
| 2494 | 2440 | 1220.0 | 45.74 | 22.9 | DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. | Christopher J Bakkenist, Michael B Kastan | Nature | 2003 | 12556884 | Yes |
| 2495 | 2440 | 1220.0 | 54.57 | 27.3 | The pathophysiology of mitochondrial cell death. | Douglas R Green, Guido Kroemer | Science | 2004 | 15286356 | No |
| 2496 | 1219 | 1219.0 | 30.97 | 31.0 | Endothelial-leukocyte adhesion molecules. | M P Bevilacqua | Annu Rev Immunol | 1993 | 8476577 | No |
| 2497 | 3657 | 1219.0 | 95.49 | 31.8 | Atomic force microscope. | Binnig, Quate, Gerber | Phys Rev Lett | 1986 | 10033323 | Yes |
| 2498 | 2437 | 1218.5 | 63.15 | 31.6 | Regulation mechanisms and signaling pathways of autophagy. | Congcong He, Daniel J Klionsky | Annu Rev Genet | 2009 | 19653858 | No |
| 2499 | 1218 | 1218.0 | 26.89 | 26.9 | Heterotrimeric G proteins: organizers of transmembrane signals. | E J Neer | Cell | 1995 | 7834744 | No |
| 2500 | 1218 | 1218.0 | 27.28 | 27.3 | The stem-cell niche as an entity of action. | David T Scadden | Nature | 2006 | 16810242 | No |
| 2501 | 2436 | 1218.0 | 101.4 | 50.7 | The M1 and M2 paradigm of macrophage activation: time for reassessment. | Fernando O Martinez, Siamon Gordon | F1000Prime Rep | 2014 | 24669294 | No |
| 2502 | 2433 | 1216.5 | 96.75 | 48.4 | Neoantigens in cancer immunotherapy. | Ton N Schumacher, Robert D Schreiber | Science | 2015 | 25838375 | No |
| 2503 | 3648 | 1216.0 | 111.08 | 37.0 | Oxidants, antioxidants, and the degenerative diseases of aging. | B N Ames, M K Shigenaga, T M Hagen | Proc Natl Acad Sci U S A | 1993 | 8367443 | No |
| 2504 | 1216 | 1216.0 | 55.66 | 55.7 | Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. | P de Leva | J Biomech | 1996 | 8872282 | Yes |
| 2505 | 1216 | 1216.0 | 29.1 | 29.1 | Oxidative stress in neurodegeneration: cause or consequence? | Julie K Andersen | Nat Med | 2004 | 15298006 | No |
| 2506 | 1216 | 1216.0 | 65.78 | 65.8 | Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. | Kevin A Hallgren | Tutor Quant Methods Psychol | 2012 | 22833776 | Yes |
| 2507 | 1216 | 1216.0 | 61.62 | 61.6 | Nonalcoholic fatty liver disease: a systematic review. | Mary E Rinella | JAMA | 2015 | 26057287 | No |
| 2508 | 6079 | 1215.8 | 193.03 | 38.6 | Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. | J S Beckman, T W Beckman, J Chen, P A Marshall, B A Freeman | Proc Natl Acad Sci U S A | 1990 | 2154753 | Yes |
| 2509 | 3646 | 1215.3 | 174.62 | 58.2 | Scoping studies: advancing the methodology. | Danielle Levac, Heather Colquhoun, Kelly K O'Brien | Implement Sci | 2010 | 20854677 | Yes |
| 2510 | 2430 | 1215.0 | 0.0 | 0.0 | High resolution acrylamide gel electrophoresis of histones. | S Panyim, R Chalkley | Arch Biochem Biophys | 1969 | 5778650 | Yes |
| 2511 | 2429 | 1214.5 | 39.73 | 19.9 | A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. | D Tautz, C Pfeifle | Chromosoma | 1989 | 2476281 | Yes |
| 2512 | 2429 | 1214.5 | 47.51 | 23.8 | CpG islands in vertebrate genomes. | M Gardiner-Garden, M Frommer | J Mol Biol | 1987 | 3656447 | Yes |
| 2513 | 2428 | 1214.0 | 67.77 | 33.9 | Antibiotic resistance of bacteria in biofilms. | P S Stewart, J W Costerton | Lancet | 2001 | 11463434 | No |
| 2514 | 3642 | 1214.0 | 94.52 | 31.5 | Wnt/beta-catenin signaling: components, mechanisms, and diseases. | Bryan T MacDonald, Keiko Tamai, Xi He | Dev Cell | 2009 | 19619488 | No |
| 2515 | 1214 | 1214.0 | 40.16 | 40.2 | phangorn: phylogenetic analysis in R. | Klaus Peter Schliep | Bioinformatics | 2011 | 21169378 | Yes |
| 2516 | 1214 | 1214.0 | 38.81 | 38.8 | Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. | Charles A Dinarello | Blood | 2011 | 21304099 | No |
| 2517 | 1213 | 1213.0 | 26.32 | 26.3 | Antigen-presenting function of the macrophage. | E R Unanue | Annu Rev Immunol | 1984 | 6242349 | No |
| 2518 | 1213 | 1213.0 | 32.61 | 32.6 | Low density lipoprotein oxidation and its pathobiological significance. | D Steinberg | J Biol Chem | 1997 | 9261091 | No |
| 2519 | 1213 | 1213.0 | 29.73 | 29.7 | Somatostatin and its receptor family. | Y C Patel | Front Neuroendocrinol | 1999 | 10433861 | No |
| 2520 | 2426 | 1213.0 | 62.35 | 31.2 | Neuronal plasticity: increasing the gain in pain. | C J Woolf, M W Salter | Science | 2000 | 10846153 | No |
| 2521 | 1213 | 1213.0 | 28.08 | 28.1 | Transcriptional control of adipocyte formation. | Stephen R Farmer | Cell Metab | 2006 | 17011499 | No |
| 2522 | 2426 | 1213.0 | 66.5 | 33.2 | Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. | Gerard Talavera, Jose Castresana | Syst Biol | 2007 | 17654362 | Yes |
| 2523 | 13342 | 1212.9 | 331.37 | 30.1 | New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. | P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G Gwyther | J Natl Cancer Inst | 2000 | 10655437 | No |
| 2524 | 1212 | 1212.0 | 55.51 | 55.5 | Continuous improvement as an ideal in health care. | D M Berwick | N Engl J Med | 1989 | 2909878 | Yes |
| 2525 | 1212 | 1212.0 | 38.46 | 38.5 | Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? | Thomas Grobner | Nephrol Dial Transplant | 2006 | 16431890 | Yes |
| 2526 | 2424 | 1212.0 | 63.95 | 32.0 | Myocardial reperfusion injury. | Derek M Yellon, Derek J Hausenloy | N Engl J Med | 2007 | 17855673 | No |
| 2527 | 2423 | 1211.5 | 0.0 | 0.0 | Surgical risk as related to time of intervention in the repair of intracranial aneurysms. | W E Hunt, R M Hess | J Neurosurg | 1968 | 5635959 | Yes |
| 2528 | 2423 | 1211.5 | 49.48 | 24.7 | Gene silencing in cancer in association with promoter hypermethylation. | James G Herman, Stephen B Baylin | N Engl J Med | 2003 | 14627790 | No |
| 2529 | 1211 | 1211.0 | 33.87 | 33.9 | Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. | F Hefti | J Neurosci | 1986 | 3746405 | Yes |
| 2530 | 1211 | 1211.0 | 36.17 | 36.2 | Invasive aspergillosis. | D W Denning | Clin Infect Dis | 1998 | 9564455 | No |
| 2531 | 1211 | 1211.0 | 0.0 | 0.0 | Observations on the isolated phrenic nerve diaphragm preparation of the rat. | E Bulbring | Br J Pharmacol Chemother | 1946 | 20999334 | Yes |
| 2532 | 1210 | 1210.0 | 60.62 | 60.6 | The clinical application of the biopsychosocial model. | G L Engel | Am J Psychiatry | 1980 | 7369396 | Yes |
| 2533 | 2419 | 1209.5 | 78.48 | 39.2 | Accessories to the crime: functions of cells recruited to the tumor microenvironment. | Douglas Hanahan, Lisa M Coussens | Cancer Cell | 2012 | 22439926 | No |
| 2534 | 1209 | 1209.0 | 25.43 | 25.4 | MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. | R N Germain | Cell | 1994 | 8293464 | No |
| 2535 | 1209 | 1209.0 | 27.03 | 27.0 | Prediction of protein cellular attributes using pseudo-amino acid composition. | K C Chou | Proteins | 2001 | 11288174 | Yes |
| 2536 | 3626 | 1208.7 | 77.89 | 26.0 | Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). | Michael J Rust, Mark Bates, Xiaowei Zhuang | Nat Methods | 2006 | 16896339 | Yes |
| 2537 | 4833 | 1208.2 | 130.85 | 32.7 | Microbial ecology: human gut microbes associated with obesity. | Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I Gordon | Nature | 2006 | 17183309 | Yes |
| 2538 | 1208 | 1208.0 | 31.05 | 31.1 | Surrogate endpoints in clinical trials: definition and operational criteria. | R L Prentice | Stat Med | 1989 | 2727467 | Yes |
| 2539 | 1208 | 1208.0 | 38.33 | 38.3 | Linkage map of Escherichia coli K-12, edition 7. | B J Bachmann | Microbiol Rev | 1983 | 6348505 | No |
| 2540 | 1208 | 1208.0 | 26.03 | 26.0 | Dendritic cells: unique leukocyte populations which control the primary immune response. | D N Hart | Blood | 1997 | 9345009 | No |
| 2541 | 1208 | 1208.0 | 0.0 | 0.0 | Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. | J M Van Rossum | Arch Int Pharmacodyn Ther | 1963 | 13996119 | Yes |
| 2542 | 2415 | 1207.5 | 48.08 | 24.0 | Checkpoints: controls that ensure the order of cell cycle events. | L H Hartwell, T A Weinert | Science | 1989 | 2683079 | No |
| 2543 | 2414 | 1207.0 | 0.0 | 0.0 | The Aggregation Of Blood Platelets. | G V Born, M J Cross | J Physiol | 1963 | 14056485 | Yes |
| 2544 | 3620 | 1206.7 | 87.43 | 29.1 | Dystrophin: the protein product of the Duchenne muscular dystrophy locus. | E P Hoffman, R H Brown, L M Kunkel | Cell | 1987 | 3319190 | Yes |
| 2545 | 1206 | 1206.0 | 29.71 | 29.7 | Bcl-2 initiates a new category of oncogenes: regulators of cell death. | S J Korsmeyer | Blood | 1992 | 1498330 | No |
| 2546 | 3618 | 1206.0 | 91.62 | 30.5 | Functional porous coordination polymers. | Susumu Kitagawa, Ryo Kitaura, Shin-ichiro Noro | Angew Chem Int Ed Engl | 2004 | 15114565 | Yes |
| 2547 | 1206 | 1206.0 | 29.05 | 29.1 | The path to ubiquitous and low-cost organic electronic appliances on plastic. | Stephen R Forrest | Nature | 2004 | 15118718 | Yes |
| 2548 | 3615 | 1205.0 | 63.29 | 21.1 | A system for stable expression of short interfering RNAs in mammalian cells. | Thijn R Brummelkamp, René Bernards, Reuven Agami | Science | 2002 | 11910072 | Yes |
| 2549 | 1205 | 1205.0 | 23.53 | 23.5 | Mobile elements: drivers of genome evolution. | Haig H Kazazian | Science | 2004 | 15016989 | No |
| 2550 | 1205 | 1205.0 | 49.94 | 49.9 | Cytokines in inflammatory bowel disease. | Markus F Neurath | Nat Rev Immunol | 2014 | 24751956 | No |
| 2551 | 1204 | 1204.0 | 29.3 | 29.3 | Reactive oxygen radicals in signaling and damage in the ischemic brain. | P H Chan | J Cereb Blood Flow Metab | 2001 | 11149664 | No |
| 2552 | 3612 | 1204.0 | 89.26 | 29.8 | Thresholding of statistical maps in functional neuroimaging using the false discovery rate. | Christopher R Genovese, Nicole A Lazar, Thomas Nichols | Neuroimage | 2002 | 11906227 | Yes |
| 2553 | 1204 | 1204.0 | 0.0 | 0.0 | The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. | G A Rose | Bull World Health Organ | 1962 | 13974778 | Yes |
| 2554 | 4816 | 1204.0 | 101.21 | 25.3 | Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. | D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini | Science | 2005 | 15718470 | Yes |
| 2555 | 2406 | 1203.0 | 46.33 | 23.2 | The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. | T Maehama, J E Dixon | J Biol Chem | 1998 | 9593664 | Yes |
| 2556 | 2405 | 1202.5 | 75.53 | 37.8 | Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. | J E Hixson, D T Vernier | J Lipid Res | 1990 | 2341813 | Yes |
| 2557 | 3607 | 1202.3 | 111.53 | 37.2 | Dose translation from animal to human studies revisited. | Shannon Reagan-Shaw, Minakshi Nihal, Nihal Ahmad | FASEB J | 2008 | 17942826 | Yes |
| 2558 | 10819 | 1202.1 | 670.85 | 74.5 | Cancer statistics in China, 2015. | Wanqing Chen, Rongshou Zheng, Peter D Baade, Siwei Zhang, Hongmei Zeng, Freddie Bray, Ahmedin Jemal, Xue Qin Yu, Jie He | CA Cancer J Clin | 2016 | 26808342 | Yes |
| 2559 | 1202 | 1202.0 | 28.55 | 28.6 | Growth factors and cancer. | S A Aaronson | Science | 1991 | 1659742 | No |
| 2560 | 1202 | 1202.0 | 27.4 | 27.4 | Long-term potentiation and memory. | M A Lynch | Physiol Rev | 2004 | 14715912 | No |
| 2561 | 1201 | 1201.0 | 37.33 | 37.3 | Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. | E N Bergman | Physiol Rev | 1990 | 2181501 | No |
| 2562 | 2402 | 1201.0 | 63.5 | 31.8 | Nanostructures in biodiagnostics. | Nathaniel L Rosi, Chad A Mirkin | Chem Rev | 2005 | 15826019 | No |
| 2563 | 6003 | 1200.6 | 230.78 | 46.2 | The hallmarks of aging. | Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer | Cell | 2013 | 23746838 | No |
| 2564 | 2401 | 1200.5 | 124.85 | 62.4 | A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. | M Roland, R Morris | Spine (Phila Pa 1976) | 1983 | 6222486 | Yes |
| 2565 | 1200 | 1200.0 | 27.37 | 27.4 | Hybridization of denatured RNA transferred or dotted nitrocellulose paper. | P S Thomas | Methods Enzymol | 1983 | 6194404 | Yes |
| 2566 | 1200 | 1200.0 | 29.84 | 29.8 | Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. | P Kuzmic | Anal Biochem | 1996 | 8660575 | Yes |
| 2567 | 1200 | 1200.0 | 0.0 | 0.0 | A Protection Motivation Theory of Fear Appeals and Attitude Change1. | Ronald W Rogers | J Psychol | 1975 | 28136248 | Yes |
| 2568 | 2399 | 1199.5 | 62.09 | 31.0 | Microglia: active sensor and versatile effector cells in the normal and pathologic brain. | Uwe-Karsten Hanisch, Helmut Kettenmann | Nat Neurosci | 2007 | 17965659 | No |
| 2569 | 1199 | 1199.0 | 21.34 | 21.3 | Cancer susceptibility and the functions of BRCA1 and BRCA2. | Ashok R Venkitaraman | Cell | 2002 | 11832208 | No |
| 2570 | 1199 | 1199.0 | 32.25 | 32.2 | Plasmonics: merging photonics and electronics at nanoscale dimensions. | Ekmel Ozbay | Science | 2006 | 16410515 | Yes |
| 2571 | 1199 | 1199.0 | 29.78 | 29.8 | Huntington's disease. | Francis O Walker | Lancet | 2007 | 17240289 | No |
| 2572 | 9591 | 1198.9 | 294.42 | 36.8 | The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. | Ziad S Nasreddine, Natalie A Phillips, Valérie Bédirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard Chertkow | J Am Geriatr Soc | 2005 | 15817019 | Yes |
| 2573 | 4793 | 1198.2 | 169.88 | 42.5 | Guidelines for the process of cross-cultural adaptation of self-report measures. | D E Beaton, C Bombardier, F Guillemin, M B Ferraz | Spine (Phila Pa 1976) | 2000 | 11124735 | No |
| 2574 | 1198 | 1198.0 | 59.32 | 59.3 | ROC methodology in radiologic imaging. | C E Metz | Invest Radiol | 1986 | 3095258 | No |
| 2575 | 1197 | 1197.0 | 48.5 | 48.5 | Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. | E H Beachey | J Infect Dis | 1981 | 7014727 | No |
| 2576 | 3591 | 1197.0 | 77.17 | 25.7 | Calcium signalling: dynamics, homeostasis and remodelling. | Michael J Berridge, Martin D Bootman, H Llewelyn Roderick | Nat Rev Mol Cell Biol | 2003 | 12838335 | No |
| 2577 | 1197 | 1197.0 | 31.72 | 31.7 | Wound healing and its impairment in the diabetic foot. | Vincent Falanga | Lancet | 2005 | 16291068 | No |
| 2578 | 1197 | 1197.0 | 33.55 | 33.5 | The sympathetic control of blood pressure. | Patrice G Guyenet | Nat Rev Neurosci | 2006 | 16760914 | No |
| 2579 | 3588 | 1196.0 | 91.46 | 30.5 | LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. | A C Wallace, R A Laskowski, J M Thornton | Protein Eng | 1995 | 7630882 | Yes |
| 2580 | 2391 | 1195.5 | 60.99 | 30.5 | Rising incidence of hepatocellular carcinoma in the United States. | H B El-Serag, A C Mason | N Engl J Med | 1999 | 10072408 | Yes |
| 2581 | 1195 | 1195.0 | 56.14 | 56.1 | A cognitive approach to panic. | D M Clark | Behav Res Ther | 1986 | 3741311 | Yes |
| 2582 | 3585 | 1195.0 | 73.09 | 24.4 | The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. | Fabio Martinon, Kimberly Burns, Jürg Tschopp | Mol Cell | 2002 | 12191486 | Yes |
| 2583 | 1195 | 1195.0 | 0.0 | 0.0 | The cytoarchitectonic organization of the spinal cord in the cat. | B Rexed | J Comp Neurol | 1952 | 14946260 | Yes |
| 2584 | 2390 | 1195.0 | 59.72 | 29.9 | Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. | Kornelia Polyak, Robert A Weinberg | Nat Rev Cancer | 2009 | 19262571 | No |
| 2585 | 2390 | 1195.0 | 60.83 | 30.4 | Microenvironmental regulation of metastasis. | Johanna A Joyce, Jeffrey W Pollard | Nat Rev Cancer | 2009 | 19279573 | No |
| 2586 | 1195 | 1195.0 | 0.0 | 0.0 | An approximate distribution of estimates of variance components. | F E Satterthwaite | Biometrics | 1946 | 20287815 | Yes |
| 2587 | 2390 | 1195.0 | 67.52 | 33.8 | Alternative activation of macrophages: mechanism and functions. | Siamon Gordon, Fernando O Martinez | Immunity | 2010 | 20510870 | No |
| 2588 | 1194 | 1194.0 | 29.91 | 29.9 | Hereditary cancer, oncogenes, and antioncogenes. | A G Knudson | Cancer Res | 1985 | 2983882 | Yes |
| 2589 | 1194 | 1194.0 | 38.16 | 38.2 | Antioxidants in human health and disease. | B Halliwell | Annu Rev Nutr | 1996 | 8839918 | No |
| 2590 | 1194 | 1194.0 | 27.09 | 27.1 | Nuclear factor-kappaB: the enemy within. | Bharat B Aggarwal | Cancer Cell | 2004 | 15380510 | No |
| 2591 | 1193 | 1193.0 | 0.0 | 0.0 | Displaced proximal humeral fractures. I. Classification and evaluation. | C S Neer | J Bone Joint Surg Am | 1970 | 5455339 | Yes |
| 2592 | 1193 | 1193.0 | 0.0 | 0.0 | Studies on phosphatidylcholine vesicles. Formation and physical characteristics. | C Huang | Biochemistry | 1969 | 5777332 | Yes |
| 2593 | 1193 | 1193.0 | 45.55 | 45.5 | Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. | S H Safe | Crit Rev Toxicol | 1994 | 8037844 | No |
| 2594 | 3577 | 1192.3 | 107.53 | 35.8 | The functional anatomy of basal ganglia disorders. | R L Albin, A B Young, J B Penney | Trends Neurosci | 1989 | 2479133 | No |
| 2595 | 1192 | 1192.0 | 43.38 | 43.4 | Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. | R M Post | Am J Psychiatry | 1992 | 1353322 | No |
| 2596 | 1192 | 1192.0 | 0.0 | 0.0 | Assay of intestinal disaccharidases. | A Dahlqvist | Anal Biochem | 1968 | 5636962 | Yes |
| 2597 | 3576 | 1192.0 | 99.01 | 33.0 | Molecular characterization of a peripheral receptor for cannabinoids. | S Munro, K L Thomas, M Abu-Shaar | Nature | 1993 | 7689702 | Yes |
| 2598 | 1192 | 1192.0 | 25.17 | 25.2 | The lasso method for variable selection in the Cox model. | R Tibshirani | Stat Med | 1997 | 9044528 | Yes |
| 2599 | 1192 | 1192.0 | 29.87 | 29.9 | The neuropathology of schizophrenia. A critical review of the data and their interpretation. | P J Harrison | Brain | 1999 | 10219775 | No |
| 2600 | 1192 | 1192.0 | 37.1 | 37.1 | Chronic disease management: what will it take to improve care for chronic illness? | E H Wagner | Eff Clin Pract | 1998 | 10345255 | No |
| 2601 | 1192 | 1192.0 | 26.07 | 26.1 | The finer things in X-ray diffraction data collection. | J W Pflugrath | Acta Crystallogr D Biol Crystallogr | 1999 | 10531521 | Yes |
| 2602 | 1192 | 1192.0 | 26.85 | 26.9 | S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. | R Donato | Int J Biochem Cell Biol | 2001 | 11390274 | No |
| 2603 | 1192 | 1192.0 | 21.85 | 21.9 | The molecular motor toolbox for intracellular transport. | Ronald D Vale | Cell | 2003 | 12600311 | No |
| 2604 | 1192 | 1192.0 | 36.56 | 36.6 | Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. | Felix Kratz | J Control Release | 2008 | 18582981 | No |
| 2605 | 3575 | 1191.7 | 86.62 | 28.9 | Global and societal implications of the diabetes epidemic. | P Zimmet, K G Alberti, J Shaw | Nature | 2001 | 11742409 | No |
| 2606 | 5958 | 1191.6 | 114.88 | 23.0 | Crystal structure of the nucleosome core particle at 2.8 A resolution. | K Luger, A W Mäder, R K Richmond, D F Sargent, T J Richmond | Nature | 1997 | 9305837 | Yes |
| 2607 | 2382 | 1191.0 | 64.39 | 32.2 | Leukocyte-endothelial adhesion molecules. | T M Carlos, J M Harlan | Blood | 1994 | 7522621 | No |
| 2608 | 1191 | 1191.0 | 28.75 | 28.8 | Pathways of oxidative damage. | James A Imlay | Annu Rev Microbiol | 2003 | 14527285 | No |
| 2609 | 2381 | 1190.5 | 83.11 | 41.6 | Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. | Riccardo Lencioni, Josep M Llovet | Semin Liver Dis | 2010 | 20175033 | No |
| 2610 | 1190 | 1190.0 | 0.0 | 0.0 | Campylobacter enteritis: a "new" disease. | M B Skirrow | Br Med J | 1977 | 871765 | Yes |
| 2611 | 1190 | 1190.0 | 25.26 | 25.3 | Caspase structure, proteolytic substrates, and function during apoptotic cell death. | D W Nicholson | Cell Death Differ | 1999 | 10578171 | No |
| 2612 | 1190 | 1190.0 | 22.83 | 22.8 | Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. | Ricky W Johnstone | Nat Rev Drug Discov | 2002 | 12120280 | No |
| 2613 | 1190 | 1190.0 | 0.0 | 0.0 | The generalisation of student's problems when several different population variances are involved. | B L Welch | Biometrika | 1947 | 20287819 | Yes |
| 2614 | 2378 | 1189.0 | 55.02 | 27.5 | Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. | T Hunter, B M Sefton | Proc Natl Acad Sci U S A | 1980 | 6246487 | Yes |
| 2615 | 1189 | 1189.0 | 31.44 | 31.4 | Drug delivery and targeting. | R Langer | Nature | 1998 | 9579855 | No |
| 2616 | 2378 | 1189.0 | 50.75 | 25.4 | ERBB receptors and cancer: the complexity of targeted inhibitors. | Nancy E Hynes, Heidi A Lane | Nat Rev Cancer | 2005 | 15864276 | No |
| 2617 | 1189 | 1189.0 | 38.66 | 38.7 | Mitochondria and cancer. | Douglas C Wallace | Nat Rev Cancer | 2012 | 23001348 | No |
| 2618 | 2376 | 1188.0 | 0.0 | 0.0 | Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. | J D Peuler, G A Johnson | Life Sci | 1977 | 904439 | Yes |
| 2619 | 2376 | 1188.0 | 92.74 | 46.4 | Malondialdehyde determination as index of lipid peroxidation. | H H Draper, M Hadley | Methods Enzymol | 1990 | 2233309 | Yes |
| 2620 | 1188 | 1188.0 | 28.79 | 28.8 | Intracellular protein topogenesis. | G Blobel | Proc Natl Acad Sci U S A | 1980 | 6929499 | Yes |
| 2621 | 2376 | 1188.0 | 56.7 | 28.4 | Peroxisome proliferator-activated receptors: nuclear control of metabolism. | B Desvergne, W Wahli | Endocr Rev | 1999 | 10529898 | No |
| 2622 | 1188 | 1188.0 | 34.64 | 34.6 | Varieties of impulsivity. | J L Evenden | Psychopharmacology (Berl) | 1999 | 10550486 | No |
| 2623 | 4752 | 1188.0 | 110.22 | 27.6 | A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. | Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry Sharpless | Angew Chem Int Ed Engl | 2002 | 12203546 | Yes |
| 2624 | 2376 | 1188.0 | 85.0 | 42.5 | How good are my data and what is the resolution? | Philip R Evans, Garib N Murshudov | Acta Crystallogr D Biol Crystallogr | 2013 | 23793146 | Yes |
| 2625 | 1187 | 1187.0 | 44.88 | 44.9 | A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. | S T Tiffany | Psychol Rev | 1990 | 2186423 | No |
| 2626 | 1187 | 1187.0 | 41.71 | 41.7 | Inhibition and facilitation of nucleic acid amplification. | I G Wilson | Appl Environ Microbiol | 1997 | 9327537 | No |
| 2627 | 2373 | 1186.5 | 64.61 | 32.3 | Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. | M A Pfeffer, E Braunwald | Circulation | 1990 | 2138525 | No |
| 2628 | 1186 | 1186.0 | 38.15 | 38.1 | The pathogenesis of sepsis. | R C Bone | Ann Intern Med | 1991 | 1872494 | No |
| 2629 | 1186 | 1186.0 | 39.57 | 39.6 | Breakthrough of the year 2013. Cancer immunotherapy. | Jennifer Couzin-Frankel | Science | 2013 | 24357284 | No |
| 2630 | 3557 | 1185.7 | 102.25 | 34.1 | Nitric oxide and peroxynitrite in health and disease. | Pál Pacher, Joseph S Beckman, Lucas Liaudet | Physiol Rev | 2007 | 17237348 | No |
| 2631 | 1185 | 1185.0 | 0.0 | 0.0 | Mutation selection and the natural history of cancer. | J Cairns | Nature | 1975 | 1143315 | Yes |
| 2632 | 1185 | 1185.0 | 54.34 | 54.3 | Biomaterial-centered infection: microbial adhesion versus tissue integration. | A G Gristina | Science | 1987 | 3629258 | Yes |
| 2633 | 1185 | 1185.0 | 33.48 | 33.5 | Diversity of group types, regulation, and function of phospholipase A2. | E A Dennis | J Biol Chem | 1994 | 8175726 | No |
| 2634 | 1185 | 1185.0 | 22.17 | 22.2 | Kinesin and dynein superfamily proteins and the mechanism of organelle transport. | N Hirokawa | Science | 1998 | 9438838 | No |
| 2635 | 1185 | 1185.0 | 42.75 | 42.8 | Plasma perspective on strong field multiphoton ionization. | Corkum | Phys Rev Lett | 1993 | 10054556 | Yes |
| 2636 | 2370 | 1185.0 | 50.77 | 25.4 | Tumorigenesis and the angiogenic switch. | Gabriele Bergers, Laura E Benjamin | Nat Rev Cancer | 2003 | 12778130 | No |
| 2637 | 1185 | 1185.0 | 0.0 | 0.0 | The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. | W G Duncombe | Clin Chim Acta | 1964 | 14122498 | Yes |
| 2638 | 1185 | 1185.0 | 32.51 | 32.5 | Mitochondrial fusion and fission in cell life and death. | Benedikt Westermann | Nat Rev Mol Cell Biol | 2010 | 21102612 | No |
| 2639 | 2369 | 1184.5 | 76.21 | 38.1 | An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. | O Johnell, J A Kanis | Osteoporos Int | 2006 | 16983459 | Yes |
| 2640 | 3553 | 1184.3 | 102.5 | 34.2 | Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. | H King, R E Aubert, W H Herman | Diabetes Care | 1998 | 9727886 | Yes |
| 2641 | 1184 | 1184.0 | 47.82 | 47.8 | Social phobia. | M R Liebowitz | Mod Probl Pharmacopsychiatry | 1987 | 2885745 | Yes |
| 2642 | 1184 | 1184.0 | 24.63 | 24.6 | Morphogenetic roles of classic cadherins. | M Takeichi | Curr Opin Cell Biol | 1995 | 8573335 | No |
| 2643 | 3552 | 1184.0 | 80.05 | 26.7 | Adjusting batch effects in microarray expression data using empirical Bayes methods. | W Evan Johnson, Cheng Li, Ariel Rabinovic | Biostatistics | 2007 | 16632515 | Yes |
| 2644 | 1183 | 1183.0 | 35.02 | 35.0 | The fetal and infant origins of adult disease. | D J Barker | BMJ | 1990 | 2252919 | No |
| 2645 | 2366 | 1183.0 | 55.09 | 27.5 | Can the pharmaceutical industry reduce attrition rates? | Ismail Kola, John Landis | Nat Rev Drug Discov | 2004 | 15286737 | No |
| 2646 | 1182 | 1182.0 | 0.0 | 0.0 | Measurement of feelings using visual analogue scales. | R C Aitken | Proc R Soc Med | 1969 | 4899510 | No |
| 2647 | 1182 | 1182.0 | 31.39 | 31.4 | Psychological and neural mechanisms of the affective dimension of pain. | D D Price | Science | 2000 | 10846154 | No |
| 2648 | 2363 | 1181.5 | 64.26 | 32.1 | A review of central 5-HT receptors and their function. | N M Barnes, T Sharp | Neuropharmacology | 1999 | 10462127 | No |
| 2649 | 1181 | 1181.0 | 31.78 | 31.8 | The lipocalin protein family: structure and function. | D R Flower | Biochem J | 1996 | 8761444 | No |
| 2650 | 1181 | 1181.0 | 46.31 | 46.3 | Translating social ecological theory into guidelines for community health promotion. | D Stokols | Am J Health Promot | 1996 | 10159709 | No |
| 2651 | 3543 | 1181.0 | 73.75 | 24.6 | Large-scale analysis of the yeast proteome by multidimensional protein identification technology. | M P Washburn, D Wolters, J R Yates | Nat Biotechnol | 2001 | 11231557 | Yes |
| 2652 | 1181 | 1181.0 | 27.68 | 27.7 | Liver fibrosis -- from bench to bedside. | Scott L Friedman | J Hepatol | 2003 | 12591185 | No |
| 2653 | 1181 | 1181.0 | 31.4 | 31.4 | Pain and emotion interactions in subregions of the cingulate gyrus. | Brent A Vogt | Nat Rev Neurosci | 2005 | 15995724 | No |
| 2654 | 7083 | 1180.5 | 227.19 | 37.9 | A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. | Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier | Science | 2012 | 22745249 | Yes |
| 2655 | 1180 | 1180.0 | 23.74 | 23.7 | Lipid rafts: elusive or illusive? | Sean Munro | Cell | 2003 | 14622593 | No |
| 2656 | 16510 | 1179.3 | 362.35 | 25.9 | Crystallography & NMR system: A new software suite for macromolecular structure determination. | A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L Warren | Acta Crystallogr D Biol Crystallogr | 1998 | 9757107 | Yes |
| 2657 | 1179 | 1179.0 | 36.79 | 36.8 | Biosynthesis and metabolism of endothelium-derived nitric oxide. | L J Ignarro | Annu Rev Pharmacol Toxicol | 1990 | 2188578 | No |
| 2658 | 1179 | 1179.0 | 40.7 | 40.7 | Apoptosis in cancer: from pathogenesis to treatment. | Rebecca S Y Wong | J Exp Clin Cancer Res | 2011 | 21943236 | No |
| 2659 | 2357 | 1178.5 | 56.62 | 28.3 | Emerging roles of caspase-3 in apoptosis. | A G Porter, R U Jänicke | Cell Death Differ | 1999 | 10200555 | No |
| 2660 | 2357 | 1178.5 | 107.13 | 53.6 | Alginate: properties and biomedical applications. | Kuen Yong Lee, David J Mooney | Prog Polym Sci | 2012 | 22125349 | Yes |
| 2661 | 1178 | 1178.0 | 28.52 | 28.5 | Rapid and sensitive sequence comparison with FASTP and FASTA. | W R Pearson | Methods Enzymol | 1990 | 2156132 | Yes |
| 2662 | 1178 | 1178.0 | 40.97 | 41.0 | The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. | N M Kaplan | Arch Intern Med | 1989 | 2662932 | No |
| 2663 | 1178 | 1178.0 | 34.79 | 34.8 | Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. | W Sieghart | Pharmacol Rev | 1995 | 7568326 | No |
| 2664 | 1178 | 1178.0 | 29.88 | 29.9 | Optimal experimental design for event-related fMRI. | A M Dale | Hum Brain Mapp | 1999 | 10524601 | Yes |
| 2665 | 1178 | 1178.0 | 28.02 | 28.0 | Metastatic bone disease: clinical features, pathophysiology and treatment strategies. | R E Coleman | Cancer Treat Rev | 2001 | 11417967 | No |
| 2666 | 1178 | 1178.0 | 36.05 | 36.0 | Cytokinesis-block micronucleus cytome assay. | Michael Fenech | Nat Protoc | 2007 | 17546000 | Yes |
| 2667 | 1177 | 1177.0 | 32.61 | 32.6 | The biochemistry and medical significance of the flavonoids. | Bent H Havsteen | Pharmacol Ther | 2002 | 12453566 | No |
| 2668 | 1177 | 1177.0 | 31.8 | 31.8 | Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. | G L Semenza | Oncogene | 2010 | 19946328 | No |
| 2669 | 1176 | 1176.0 | 0.0 | 0.0 | Histological demonstration of mucin after periodic acid. | J F A McMANUS | Nature | 1946 | 20995486 | Yes |
| 2670 | 2349 | 1174.5 | 47.96 | 24.0 | Molecular chaperones in the cytosol: from nascent chain to folded protein. | F Ulrich Hartl, Manajit Hayer-Hartl | Science | 2002 | 11884745 | No |
| 2671 | 3523 | 1174.3 | 126.22 | 42.1 | Rehospitalizations among patients in the Medicare fee-for-service program. | Stephen F Jencks, Mark V Williams, Eric A Coleman | N Engl J Med | 2009 | 19339721 | Yes |
| 2672 | 1174 | 1174.0 | 36.19 | 36.2 | The mysteries of lipoprotein(a). | G Utermann | Science | 1989 | 2530631 | No |
| 2673 | 1174 | 1174.0 | 39.58 | 39.6 | Interleukin-1 and the pathogenesis of the acute-phase response. | C A Dinarello | N Engl J Med | 1984 | 6208485 | No |
| 2674 | 3522 | 1174.0 | 86.39 | 28.8 | Functional diversity of helper T lymphocytes. | A K Abbas, K M Murphy, A Sher | Nature | 1996 | 8893001 | No |
| 2675 | 1174 | 1174.0 | 37.99 | 38.0 | Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. | J J Gross | J Pers Soc Psychol | 1998 | 9457784 | Yes |
| 2676 | 1174 | 1174.0 | 53.69 | 53.7 | Working memory: theories, models, and controversies. | Alan Baddeley | Annu Rev Psychol | 2012 | 21961947 | No |
| 2677 | 2347 | 1173.5 | 158.67 | 79.3 | Facial nerve grading system. | J W House, D E Brackmann | Otolaryngol Head Neck Surg | 1985 | 3921901 | Yes |
| 2678 | 1173 | 1173.0 | 0.0 | 0.0 | Nontuberculous mycobacteria and associated diseases. | E Wolinsky | Am Rev Respir Dis | 1979 | 369415 | No |
| 2679 | 1173 | 1173.0 | 0.0 | 0.0 | Optimal foraging, the marginal value theorem. | E L Charnov | Theor Popul Biol | 1976 | 1273796 | Yes |
| 2680 | 1173 | 1173.0 | 52.77 | 52.8 | Presynaptic regulation of the release of catecholamines. | S Z Langer | Pharmacol Rev | 1980 | 6267618 | Yes |
| 2681 | 10556 | 1172.9 | 357.2 | 39.7 | A novel potent vasoconstrictor peptide produced by vascular endothelial cells. | M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T Masaki | Nature | 1988 | 2451132 | Yes |
| 2682 | 1172 | 1172.0 | 49.07 | 49.1 | Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). | S Safe | Crit Rev Toxicol | 1990 | 2124811 | No |
| 2683 | 1172 | 1172.0 | 26.13 | 26.1 | The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. | S J Collins | Blood | 1987 | 3311197 | No |
| 2684 | 2344 | 1172.0 | 95.42 | 47.7 | Rapid procedure for detection and isolation of large and small plasmids. | C I Kado, S T Liu | J Bacteriol | 1981 | 7009583 | Yes |
| 2685 | 1172 | 1172.0 | 0.0 | 0.0 | A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. | J B Brown | Biochem J | 1955 | 14389222 | Yes |
| 2686 | 2344 | 1172.0 | 59.59 | 29.8 | Drug delivery systems: entering the mainstream. | Theresa M Allen, Pieter R Cullis | Science | 2004 | 15031496 | Yes |
| 2687 | 1172 | 1172.0 | 0.0 | 0.0 | A simple objective technique for measuring flexibility in thinking. | E A Berg | J Gen Psychol | 1948 | 18889466 | Yes |
| 2688 | 2343 | 1171.5 | 46.24 | 23.1 | Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. | C W Greider, E H Blackburn | Cell | 1985 | 3907856 | Yes |
| 2689 | 7027 | 1171.2 | 185.89 | 31.0 | Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. | Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat Robles | Bioinformatics | 2005 | 16081474 | Yes |
| 2690 | 1171 | 1171.0 | 26.71 | 26.7 | Translating cell biology into therapeutic advances in Alzheimer's disease. | D J Selkoe | Nature | 1999 | 10392577 | No |
| 2691 | 2342 | 1171.0 | 70.91 | 35.5 | A cognitive model of posttraumatic stress disorder. | A Ehlers, D M Clark | Behav Res Ther | 2000 | 10761279 | No |
| 2692 | 4684 | 1171.0 | 101.95 | 25.5 | Interleukin-10 and the interleukin-10 receptor. | K W Moore, R de Waal Malefyt, R L Coffman, A O'Garra | Annu Rev Immunol | 2001 | 11244051 | No |
| 2693 | 1171 | 1171.0 | 29.52 | 29.5 | Primate anterior cingulate cortex: where motor control, drive and cognition interface. | T Paus | Nat Rev Neurosci | 2001 | 11389475 | No |
| 2694 | 3513 | 1171.0 | 86.42 | 28.8 | Tissue cells feel and respond to the stiffness of their substrate. | Dennis E Discher, Paul Janmey, Yu-Li Wang | Science | 2005 | 16293750 | No |
| 2695 | 2341 | 1170.5 | 0.0 | 0.0 | Construct validity in psychological tests. | L J Cronbach, P E Meehl | Psychol Bull | 1955 | 13245896 | Yes |
| 2696 | 1170 | 1170.0 | 0.0 | 0.0 | Experience from a multicentre stroke register: a preliminary report. | S Hatano | Bull World Health Organ | 1976 | 1088404 | Yes |
| 2697 | 1170 | 1170.0 | 25.22 | 25.2 | Platelets in atherothrombosis. | Zaverio M Ruggeri | Nat Med | 2002 | 12411949 | No |
| 2698 | 7019 | 1169.8 | 135.91 | 22.7 | Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. | S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T Tuschl | Nature | 2001 | 11373684 | Yes |
| 2699 | 2339 | 1169.5 | 0.0 | 0.0 | The low-density lipoprotein pathway and its relation to atherosclerosis. | J L Goldstein, M S Brown | Annu Rev Biochem | 1977 | 197883 | No |
| 2700 | 2338 | 1169.0 | 52.88 | 26.4 | The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. | P M Sharp, W H Li | Nucleic Acids Res | 1987 | 3547335 | Yes |
| 2701 | 2338 | 1169.0 | 98.06 | 49.0 | Reading senseless sentences: brain potentials reflect semantic incongruity. | M Kutas, S A Hillyard | Science | 1980 | 7350657 | Yes |
| 2702 | 1169 | 1169.0 | 51.98 | 52.0 | α-band oscillations, attention, and controlled access to stored information. | Wolfgang Klimesch | Trends Cogn Sci | 2012 | 23141428 | No |
| 2703 | 1168 | 1168.0 | 19.57 | 19.6 | Themes and variations on ubiquitylation. | A M Weissman | Nat Rev Mol Cell Biol | 2001 | 11265246 | No |
| 2704 | 1167 | 1167.0 | 21.42 | 21.4 | Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. | D Hanahan | Nature | 1985 | 2986015 | Yes |
| 2705 | 1167 | 1167.0 | 0.0 | 0.0 | The concept of immunological surveillance. | F M Burnet | Prog Exp Tumor Res | 1970 | 4921480 | No |
| 2706 | 1167 | 1167.0 | 26.09 | 26.1 | Molecular physiology of low-voltage-activated t-type calcium channels. | Edward Perez-Reyes | Physiol Rev | 2003 | 12506128 | No |
| 2707 | 5834 | 1166.8 | 191.85 | 38.4 | Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. | D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L Witztum | N Engl J Med | 1989 | 2648148 | No |
| 2708 | 2333 | 1166.5 | 63.07 | 31.5 | Imaging cognition II: An empirical review of 275 PET and fMRI studies. | R Cabeza, L Nyberg | J Cogn Neurosci | 2000 | 10769304 | No |
| 2709 | 2333 | 1166.5 | 64.95 | 32.5 | Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. | Ajay Kumar Gupta, Mona Gupta | Biomaterials | 2005 | 15626447 | No |
| 2710 | 1166 | 1166.0 | 61.33 | 61.3 | Rating scales to assess depression in school-aged children. | M Kovacs | Acta Paedopsychiatr | 1981 | 7025571 | Yes |
| 2711 | 1166 | 1166.0 | 28.13 | 28.1 | Matrix proteoglycans: from molecular design to cellular function. | R V Iozzo | Annu Rev Biochem | 1998 | 9759499 | No |
| 2712 | 3498 | 1166.0 | 72.57 | 24.2 | Cellular survival: a play in three Akts. | S R Datta, A Brunet, M E Greenberg | Genes Dev | 1999 | 10579998 | No |
| 2713 | 1165 | 1165.0 | 0.0 | 0.0 | Presynaptic regulation of catecholamine release. | S Z Langer | Biochem Pharmacol | 1974 | 4617579 | No |
| 2714 | 1165 | 1165.0 | 32.79 | 32.8 | How brains beware: neural mechanisms of emotional attention. | Patrik Vuilleumier | Trends Cogn Sci | 2005 | 16289871 | Yes |
| 2715 | 3493 | 1164.3 | 0.0 | 0.0 | Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. | A L Shapiro, E Viñuela, J V Maizel | Biochem Biophys Res Commun | 1967 | 4861258 | Yes |
| 2716 | 1164 | 1164.0 | 33.69 | 33.7 | Papillary and follicular thyroid carcinoma. | M J Schlumberger | N Engl J Med | 1998 | 9445411 | No |
| 2717 | 1164 | 1164.0 | 25.52 | 25.5 | The roles of intracellular protein-degradation pathways in neurodegeneration. | David C Rubinsztein | Nature | 2006 | 17051204 | No |
| 2718 | 1164 | 1164.0 | 25.62 | 25.6 | Solving structures of protein complexes by molecular replacement with Phaser. | Airlie J McCoy | Acta Crystallogr D Biol Crystallogr | 2007 | 17164524 | Yes |
| 2719 | 1164 | 1164.0 | 29.86 | 29.9 | Non-Smad pathways in TGF-beta signaling. | Ying E Zhang | Cell Res | 2009 | 19114990 | No |
| 2720 | 2326 | 1163.0 | 70.27 | 35.1 | Recent advances in the phencyclidine model of schizophrenia. | D C Javitt, S R Zukin | Am J Psychiatry | 1991 | 1654746 | No |
| 2721 | 1163 | 1163.0 | 73.83 | 73.8 | Impingement lesions. | C S Neer | Clin Orthop Relat Res | 1983 | 6825348 | Yes |
| 2722 | 1163 | 1163.0 | 26.11 | 26.1 | Neuroligins and neurexins link synaptic function to cognitive disease. | Thomas C Südhof | Nature | 2008 | 18923512 | No |
| 2723 | 3488 | 1162.7 | 0.0 | 0.0 | Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. | A DeLean, P J Munson, D Rodbard | Am J Physiol | 1978 | 686171 | Yes |
| 2724 | 2325 | 1162.5 | 66.31 | 33.2 | Increasing incidence of thyroid cancer in the United States, 1973-2002. | Louise Davies, H Gilbert Welch | JAMA | 2006 | 16684987 | Yes |
| 2725 | 1162 | 1162.0 | 45.3 | 45.3 | Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. | H V Gelboin | Physiol Rev | 1980 | 7001511 | No |
| 2726 | 3486 | 1162.0 | 102.26 | 34.1 | Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. | Günter Oberdörster, Eva Oberdörster, Jan Oberdörster | Environ Health Perspect | 2005 | 16002369 | No |
| 2727 | 1162 | 1162.0 | 30.95 | 30.9 | Hydrogen sulphide and its therapeutic potential. | Csaba Szabó | Nat Rev Drug Discov | 2007 | 17948022 | No |
| 2728 | 1162 | 1162.0 | 36.95 | 37.0 | Endometriosis. | Serdar E Bulun | N Engl J Med | 2009 | 19144942 | No |
| 2729 | 3483 | 1161.0 | 0.0 | 0.0 | The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. | G Blessed, B E Tomlinson, M Roth | Br J Psychiatry | 1968 | 5662937 | Yes |
| 2730 | 1161 | 1161.0 | 0.0 | 0.0 | A sensitive method for the assay of 5-hydroxytryptamine. | J R Vane | Br J Pharmacol Chemother | 1957 | 13460242 | Yes |
| 2731 | 1161 | 1161.0 | 31.7 | 31.7 | Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. | Earl S Ford | Diabetes Care | 2005 | 15983333 | No |
| 2732 | 1160 | 1160.0 | 22.23 | 22.2 | Contingent genetic regulatory events in T lymphocyte activation. | G R Crabtree | Science | 1989 | 2783497 | Yes |
| 2733 | 1160 | 1160.0 | 30.64 | 30.6 | Pathogenesis of dengue: challenges to molecular biology. | S B Halstead | Science | 1988 | 3277268 | No |
| 2734 | 1160 | 1160.0 | 23.41 | 23.4 | IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. | Yong-Jun Liu | Annu Rev Immunol | 2005 | 15771572 | No |
| 2735 | 1159 | 1159.0 | 32.14 | 32.1 | Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. | U Mitzdorf | Physiol Rev | 1985 | 3880898 | No |
| 2736 | 1159 | 1159.0 | 32.93 | 32.9 | Plant productivity and environment. | J S Boyer | Science | 1982 | 17808529 | Yes |
| 2737 | 1159 | 1159.0 | 27.12 | 27.1 | The tumor microenvironment and its role in promoting tumor growth. | T L Whiteside | Oncogene | 2008 | 18836471 | No |
| 2738 | 2317 | 1158.5 | 51.06 | 25.5 | Lymphocyte homing and homeostasis. | E C Butcher, L J Picker | Science | 1996 | 8600538 | No |
| 2739 | 2316 | 1158.0 | 0.0 | 0.0 | Quantitative determination of serum triglycerides by the use of enzymes. | G Bucolo, H David | Clin Chem | 1973 | 4703655 | Yes |
| 2740 | 1158 | 1158.0 | 0.0 | 0.0 | RNA metabolism in the HeLa cell nucleus. | S Penman | J Mol Biol | 1966 | 5961144 | Yes |
| 2741 | 1158 | 1158.0 | 26.1 | 26.1 | Physiological concentrations of purines and pyrimidines. | T W Traut | Mol Cell Biochem | 1994 | 7877593 | No |
| 2742 | 1158 | 1158.0 | 45.0 | 45.0 | The role of senescent cells in ageing. | Jan M van Deursen | Nature | 2014 | 24848057 | No |
| 2743 | 2315 | 1157.5 | 0.0 | 0.0 | Plasminogen: purification from human plasma by affinity chromatography. | D G Deutsch, E T Mertz | Science | 1970 | 5475635 | Yes |
| 2744 | 1157 | 1157.0 | 34.66 | 34.7 | The Hospital Anxiety And Depression Scale. | R Philip Snaith | Health Qual Life Outcomes | 2003 | 12914662 | Yes |
| 2745 | 1157 | 1157.0 | 42.09 | 42.1 | The role of autophagy in neurodegenerative disease. | Ralph A Nixon | Nat Med | 2013 | 23921753 | No |
| 2746 | 1155 | 1155.0 | 25.97 | 26.0 | Cadherins: a molecular family important in selective cell-cell adhesion. | M Takeichi | Annu Rev Biochem | 1990 | 2197976 | No |
| 2747 | 1155 | 1155.0 | 78.69 | 78.7 | The problem of rigor in qualitative research. | M Sandelowski | ANS Adv Nurs Sci | 1986 | 3083765 | Yes |
| 2748 | 1155 | 1155.0 | 30.01 | 30.0 | Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. | G Boden | Diabetes | 1997 | 8971073 | No |
| 2749 | 1155 | 1155.0 | 26.92 | 26.9 | Mitochondrial transport of cations: channels, exchangers, and permeability transition. | P Bernardi | Physiol Rev | 1999 | 10508231 | No |
| 2750 | 1155 | 1155.0 | 36.75 | 36.8 | Risk and maintenance factors for eating pathology: a meta-analytic review. | Eric Stice | Psychol Bull | 2002 | 12206196 | No |
| 2751 | 1155 | 1155.0 | 87.45 | 87.5 | Making sense of implementation theories, models and frameworks. | Per Nilsen | Implement Sci | 2015 | 25895742 | Yes |
| 2752 | 2309 | 1154.5 | 0.0 | 0.0 | Solubilization of membranes by detergents. | A Helenius, K Simons | Biochim Biophys Acta | 1975 | 1091302 | No |
| 2753 | 2309 | 1154.5 | 0.0 | 0.0 | Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. | R W Butcher, E W Sutherland | J Biol Chem | 1962 | 13875173 | Yes |
| 2754 | 3463 | 1154.3 | 0.0 | 0.0 | High resolution two-dimensional electrophoresis of basic as well as acidic proteins. | P Z O'Farrell, H M Goodman, P H O'Farrell | Cell | 1977 | 23215 | Yes |
| 2755 | 1154 | 1154.0 | 0.0 | 0.0 | Selective coronary arteriography. I. A percutaneous transfemoral technic. | M P Judkins | Radiology | 1967 | 6048074 | Yes |
| 2756 | 1153 | 1153.0 | 40.68 | 40.7 | Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. | A J Alpert | J Chromatogr | 1990 | 2324207 | Yes |
| 2757 | 1153 | 1153.0 | 41.04 | 41.0 | The amazing osteocyte. | Lynda F Bonewald | J Bone Miner Res | 2011 | 21254230 | No |
| 2758 | 1152 | 1152.0 | 0.0 | 0.0 | Biogenic amines and the states of sleep. | M Jouvet | Science | 1969 | 4303225 | No |
| 2759 | 1152 | 1152.0 | 27.44 | 27.4 | The prefrontal cortex and cognitive control. | E K Miller | Nat Rev Neurosci | 2000 | 11252769 | No |
| 2760 | 1151 | 1151.0 | 25.57 | 25.6 | Microglia as a source and target of cytokines. | Uwe-Karsten Hanisch | Glia | 2002 | 12379902 | No |
| 2761 | 3451 | 1150.3 | 86.92 | 29.0 | Evolution and functions of long noncoding RNAs. | Chris P Ponting, Peter L Oliver, Wolf Reik | Cell | 2009 | 19239885 | No |
| 2762 | 1150 | 1150.0 | 20.73 | 20.7 | Stem cells: units of development, units of regeneration, and units in evolution. | I L Weissman | Cell | 2000 | 10647940 | No |
| 2763 | 2300 | 1150.0 | 62.55 | 31.3 | Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. | Barry J Everitt, Trevor W Robbins | Nat Neurosci | 2005 | 16251991 | No |
| 2764 | 2299 | 1149.5 | 93.32 | 46.7 | The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. | R Näätänen, T Picton | Psychophysiology | 1987 | 3615753 | Yes |
| 2765 | 2299 | 1149.5 | 51.77 | 25.9 | Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. | Eugenia E Calle, Rudolf Kaaks | Nat Rev Cancer | 2004 | 15286738 | No |
| 2766 | 3448 | 1149.3 | 100.27 | 33.4 | trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. | Salvador Capella-Gutiérrez, José M Silla-Martínez, Toni Gabaldón | Bioinformatics | 2009 | 19505945 | Yes |
| 2767 | 1149 | 1149.0 | 59.37 | 59.4 | Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. | Anna Maria Carlsson | Pain | 1983 | 6602967 | Yes |
| 2768 | 1149 | 1149.0 | 31.96 | 32.0 | Neural simulation of action: a unifying mechanism for motor cognition. | M Jeannerod | Neuroimage | 2001 | 11373140 | No |
| 2769 | 1149 | 1149.0 | 30.82 | 30.8 | Polymer conjugates as anticancer nanomedicines. | Ruth Duncan | Nat Rev Cancer | 2006 | 16900224 | No |
| 2770 | 2297 | 1148.5 | 76.47 | 38.2 | Atomic structure and chemistry of human serum albumin. | X M He, D C Carter | Nature | 1992 | 1630489 | Yes |
| 2771 | 2297 | 1148.5 | 144.83 | 72.4 | A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. | E S Grood, W J Suntay | J Biomech Eng | 1983 | 6865355 | Yes |
| 2772 | 2296 | 1148.0 | 48.84 | 24.4 | Toll-like receptors in the induction of the innate immune response. | A Aderem, R J Ulevitch | Nature | 2000 | 10963608 | No |
| 2773 | 1148 | 1148.0 | 19.79 | 19.8 | Mitotic kinases as regulators of cell division and its checkpoints. | E A Nigg | Nat Rev Mol Cell Biol | 2001 | 11413462 | No |
| 2774 | 1148 | 1148.0 | 27.19 | 27.2 | Production of recombinant protein therapeutics in cultivated mammalian cells. | Florian M Wurm | Nat Biotechnol | 2004 | 15529164 | No |
| 2775 | 1148 | 1148.0 | 26.16 | 26.2 | Recognition and processing of ubiquitin-protein conjugates by the proteasome. | Daniel Finley | Annu Rev Biochem | 2009 | 19489727 | No |
| 2776 | 2295 | 1147.5 | 0.0 | 0.0 | Growth of a rat neuroblastoma cell line in serum-free supplemented medium. | J E Bottenstein, G H Sato | Proc Natl Acad Sci U S A | 1979 | 284369 | Yes |
| 2777 | 2294 | 1147.0 | 0.0 | 0.0 | Radiological demarcation of cemented sockets in total hip replacement. | J G DeLee, J Charnley | Clin Orthop Relat Res | 1976 | 991504 | Yes |
| 2778 | 2294 | 1147.0 | 46.82 | 23.4 | A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. | N C Andrews, D V Faller | Nucleic Acids Res | 1991 | 2041787 | Yes |
| 2779 | 1147 | 1147.0 | 0.0 | 0.0 | Metabolic stability and epigenesis in randomly constructed genetic nets. | S A Kauffman | J Theor Biol | 1969 | 5803332 | Yes |
| 2780 | 1147 | 1147.0 | 26.96 | 27.0 | Brain tumors. | L M DeAngelis | N Engl J Med | 2001 | 11150363 | No |
| 2781 | 1147 | 1147.0 | 26.19 | 26.2 | Human natural killer cells. | Michael A Caligiuri | Blood | 2008 | 18650461 | No |
| 2782 | 3439 | 1146.3 | 72.92 | 24.3 | Toll-like receptors: critical proteins linking innate and acquired immunity. | S Akira, K Takeda, T Kaisho | Nat Immunol | 2001 | 11477402 | No |
| 2783 | 1146 | 1146.0 | 0.0 | 0.0 | Radioimmunological determination of human C-peptide in serum. | L G Heding | Diabetologia | 1975 | 1239396 | Yes |
| 2784 | 1146 | 1146.0 | 0.0 | 0.0 | Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. | D B Clewell | J Bacteriol | 1972 | 4336693 | Yes |
| 2785 | 1146 | 1146.0 | 32.11 | 32.1 | Internal models for motor control and trajectory planning. | M Kawato | Curr Opin Neurobiol | 1999 | 10607637 | No |
| 2786 | 1146 | 1146.0 | 0.0 | 0.0 | Diffusion-in-gel methods for immunological analysis. II. | O Ouchterlony | Prog Allergy | 1962 | 14482809 | Yes |
| 2787 | 1146 | 1146.0 | 41.37 | 41.4 | Synopsis of some recent tactical application of bioisosteres in drug design. | Nicholas A Meanwell | J Med Chem | 2011 | 21413808 | Yes |
| 2788 | 1145 | 1145.0 | 34.6 | 34.6 | Effect of anoxia on ion distribution in the brain. | A J Hansen | Physiol Rev | 1985 | 3880896 | No |
| 2789 | 1145 | 1145.0 | 0.0 | 0.0 | Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. | J O Holloszy | J Biol Chem | 1967 | 4290225 | Yes |
| 2790 | 1145 | 1145.0 | 32.38 | 32.4 | DNA topoisomerases. | M Gellert | Annu Rev Biochem | 1981 | 6267993 | No |
| 2791 | 2290 | 1145.0 | 49.64 | 24.8 | Functions of lipid rafts in biological membranes. | D A Brown, E London | Annu Rev Cell Dev Biol | 1998 | 9891780 | No |
| 2792 | 3434 | 1144.7 | 69.81 | 23.3 | Predicting coiled coils from protein sequences. | A Lupas, M Van Dyke, J Stock | Science | 1991 | 2031185 | Yes |
| 2793 | 3432 | 1144.0 | 0.0 | 0.0 | Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. | G M Wahl, M Stern, G R Stark | Proc Natl Acad Sci U S A | 1979 | 291033 | Yes |
| 2794 | 2287 | 1143.5 | 42.07 | 21.0 | Stats: transcriptional control and biological impact. | David E Levy, J E Darnell | Nat Rev Mol Cell Biol | 2002 | 12209125 | No |
| 2795 | 1143 | 1143.0 | 34.47 | 34.5 | The structure of common mental disorders. | R F Krueger | Arch Gen Psychiatry | 1999 | 10530634 | Yes |
| 2796 | 1143 | 1143.0 | 26.36 | 26.4 | Neurobiology of Pavlovian fear conditioning. | S Maren | Annu Rev Neurosci | 2001 | 11520922 | No |
| 2797 | 1143 | 1143.0 | 67.75 | 67.8 | Structure, Function, and Evolution of Coronavirus Spike Proteins. | Fang Li | Annu Rev Virol | 2016 | 27578435 | No |
| 2798 | 1142 | 1142.0 | 0.0 | 0.0 | Pathologic anatomy of the pancreas in juvenile diabetes mellitus. | W Gepts | Diabetes | 1965 | 5318831 | Yes |
| 2799 | 4568 | 1142.0 | 134.53 | 33.6 | Place navigation impaired in rats with hippocampal lesions. | R G Morris, P Garrud, J N Rawlins, J O'Keefe | Nature | 1982 | 7088155 | Yes |
| 2800 | 1142 | 1142.0 | 29.46 | 29.5 | Overview of general physiologic features and functions of vitamin D. | Hector F DeLuca | Am J Clin Nutr | 2004 | 15585789 | No |
| 2801 | 2283 | 1141.5 | 61.98 | 31.0 | Morris water maze: procedures for assessing spatial and related forms of learning and memory. | Charles V Vorhees, Michael T Williams | Nat Protoc | 2006 | 17406317 | Yes |
| 2802 | 2281 | 1140.5 | 0.0 | 0.0 | Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. | R B Gustilo, J T Anderson | J Bone Joint Surg Am | 1976 | 773941 | Yes |
| 2803 | 2281 | 1140.5 | 64.32 | 32.2 | Meeting of minds: the medial frontal cortex and social cognition. | David M Amodio, Chris D Frith | Nat Rev Neurosci | 2006 | 16552413 | No |
| 2804 | 2280 | 1140.0 | 71.34 | 35.7 | Role of oxidized low density lipoprotein in atherogenesis. | J L Witztum, D Steinberg | J Clin Invest | 1991 | 1752940 | No |
| 2805 | 1140 | 1140.0 | 40.97 | 41.0 | The LMS method for constructing normalized growth standards. | T J Cole | Eur J Clin Nutr | 1990 | 2354692 | Yes |
| 2806 | 4560 | 1140.0 | 109.05 | 27.3 | Base-calling of automated sequencer traces using phred. I. Accuracy assessment. | B Ewing, L Hillier, M C Wendl, P Green | Genome Res | 1998 | 9521921 | Yes |
| 2807 | 2279 | 1139.5 | 64.34 | 32.2 | Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. | R G Phillips, J E LeDoux | Behav Neurosci | 1992 | 1590953 | Yes |
| 2808 | 2278 | 1139.0 | 45.0 | 22.5 | Multiple nuclear factors interact with the immunoglobulin enhancer sequences. | R Sen, D Baltimore | Cell | 1986 | 3091258 | Yes |
| 2809 | 2278 | 1139.0 | 0.0 | 0.0 | Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. | J D McGhee, P H von Hippel | J Mol Biol | 1974 | 4416620 | Yes |
| 2810 | 2277 | 1138.5 | 62.71 | 31.4 | Epidemiology and outcomes of osteoporotic fractures. | Steven R Cummings, L Joseph Melton | Lancet | 2002 | 12049882 | No |
| 2811 | 2277 | 1138.5 | 65.41 | 32.7 | The cognitive control of emotion. | Kevin N Ochsner, James J Gross | Trends Cogn Sci | 2005 | 15866151 | No |
| 2812 | 1138 | 1138.0 | 0.0 | 0.0 | Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. | S Z Langer | Br J Pharmacol | 1977 | 20190 | No |
| 2813 | 1138 | 1138.0 | 0.0 | 0.0 | An approach for the treatment of penile carcinoma. | R M Cabanas | Cancer | 1977 | 837331 | Yes |
| 2814 | 1138 | 1138.0 | 34.87 | 34.9 | Low-molecular-weight heparins. | J I Weitz | N Engl J Med | 1997 | 9278467 | No |
| 2815 | 1138 | 1138.0 | 22.29 | 22.3 | Mechanisms and consequences of activation of protein kinase B/Akt. | J Downward | Curr Opin Cell Biol | 1998 | 9561851 | No |
| 2816 | 1138 | 1138.0 | 32.17 | 32.2 | The induction of pain: an integrative review. | M J Millan | Prog Neurobiol | 1999 | 9987804 | No |
| 2817 | 1138 | 1138.0 | 0.0 | 0.0 | Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. | R J Pennington | Biochem J | 1961 | 13734134 | Yes |
| 2818 | 1138 | 1138.0 | 0.0 | 0.0 | A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. | R D Hotchkiss | Arch Biochem | 1948 | 18921848 | Yes |
| 2819 | 1137 | 1137.0 | 24.39 | 24.4 | Stem cells in the central nervous system. | R McKay | Science | 1997 | 9082987 | No |
| 2820 | 1137 | 1137.0 | 30.86 | 30.9 | Q-ball imaging. | David S Tuch | Magn Reson Med | 2004 | 15562495 | Yes |
| 2821 | 3410 | 1136.7 | 0.0 | 0.0 | Cytochemical identification of monocytes and granulocytes. | L T Yam, C Y Li, W H Crosby | Am J Clin Pathol | 1971 | 5549896 | Yes |
| 2822 | 1136 | 1136.0 | 46.38 | 46.4 | Bone "mass" and the "mechanostat": a proposal. | H M Frost | Anat Rec | 1987 | 3688455 | Yes |
| 2823 | 1136 | 1136.0 | 25.34 | 25.3 | The enzymes, regulation, and genetics of bile acid synthesis. | David W Russell | Annu Rev Biochem | 2003 | 12543708 | No |
| 2824 | 2271 | 1135.5 | 52.22 | 26.1 | Toll-like receptors in innate immunity. | Kiyoshi Takeda, Shizuo Akira | Int Immunol | 2005 | 15585605 | No |
| 2825 | 1135 | 1135.0 | 36.5 | 36.5 | Molecular biology of steroid hormone synthesis. | W L Miller | Endocr Rev | 1988 | 3061784 | No |
| 2826 | 1135 | 1135.0 | 0.0 | 0.0 | An improved fluorometric assay for DNA. | R T Hinegardner | Anal Biochem | 1971 | 5544593 | Yes |
| 2827 | 1135 | 1135.0 | 0.0 | 0.0 | Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. | A B Stavitsky | J Immunol | 1954 | 13163409 | Yes |
| 2828 | 1135 | 1135.0 | 0.0 | 0.0 | On the law of effect. | R J Herrnstein | J Exp Anal Behav | 1970 | 16811440 | Yes |
| 2829 | 3403 | 1134.3 | 88.25 | 29.4 | Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. | C R Woese, O Kandler, M L Wheelis | Proc Natl Acad Sci U S A | 1990 | 2112744 | Yes |
| 2830 | 1134 | 1134.0 | 0.0 | 0.0 | Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. | M M Weiser | J Biol Chem | 1973 | 4698230 | Yes |
| 2831 | 1134 | 1134.0 | 0.0 | 0.0 | Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. | A R Midgley | Endocrinology | 1966 | 5950482 | Yes |
| 2832 | 2268 | 1134.0 | 48.69 | 24.3 | Atherosclerosis. the road ahead. | C K Glass, J L Witztum | Cell | 2001 | 11239408 | No |
| 2833 | 1134 | 1134.0 | 34.47 | 34.5 | High prevalence of vitamin D inadequacy and implications for health. | Michael F Holick | Mayo Clin Proc | 2006 | 16529140 | No |
| 2834 | 4532 | 1133.0 | 111.77 | 27.9 | Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. | H Nielsen, J Engelbrecht, S Brunak, G von Heijne | Protein Eng | 1997 | 9051728 | Yes |
| 2835 | 2266 | 1133.0 | 45.42 | 22.7 | Proliferation, cell cycle and apoptosis in cancer. | G I Evan, K H Vousden | Nature | 2001 | 11357141 | No |
| 2836 | 1133 | 1133.0 | 32.54 | 32.5 | Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. | Antoine Bechara | Nat Neurosci | 2005 | 16251988 | No |
| 2837 | 1133 | 1133.0 | 0.0 | 0.0 | pA, a new scale for the measurement of drug antagonism. | H O Schild | Br J Pharmacol Chemother | 1947 | 20258355 | Yes |
| 2838 | 6796 | 1132.7 | 231.2 | 38.5 | Antioxidant activity applying an improved ABTS radical cation decolorization assay. | R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-Evans | Free Radic Biol Med | 1999 | 10381194 | Yes |
| 2839 | 4530 | 1132.5 | 112.37 | 28.1 | Autophagy fights disease through cellular self-digestion. | Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky | Nature | 2008 | 18305538 | No |
| 2840 | 1132 | 1132.0 | 47.79 | 47.8 | A cochlear frequency-position function for several species--29 years later. | D D Greenwood | J Acoust Soc Am | 1990 | 2373794 | Yes |
| 2841 | 2264 | 1132.0 | 66.71 | 33.4 | Excitatory amino acids as a final common pathway for neurologic disorders. | S A Lipton, P A Rosenberg | N Engl J Med | 1994 | 7905600 | No |
| 2842 | 1132 | 1132.0 | 28.17 | 28.2 | Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. | Hiroshi Takayanagi | Nat Rev Immunol | 2007 | 17380158 | No |
| 2843 | 1131 | 1131.0 | 0.0 | 0.0 | 6-Hydroxy-dopamine induced degeneration of central monoamine neurons. | U Ungerstedt | Eur J Pharmacol | 1968 | 5718510 | Yes |
| 2844 | 1131 | 1131.0 | 26.69 | 26.7 | Amyloid, the presenilins and Alzheimer's disease. | J Hardy | Trends Neurosci | 1997 | 9106355 | No |
| 2845 | 1131 | 1131.0 | 29.62 | 29.6 | Neural systems for recognizing emotion. | Ralph Adolphs | Curr Opin Neurobiol | 2002 | 12015233 | No |
| 2846 | 1131 | 1131.0 | 33.02 | 33.0 | The pollution of the marine environment by plastic debris: a review. | José G B Derraik | Mar Pollut Bull | 2002 | 12405208 | No |
| 2847 | 1131 | 1131.0 | 23.77 | 23.8 | Basement membranes: structure, assembly and role in tumour angiogenesis. | Raghu Kalluri | Nat Rev Cancer | 2003 | 12778132 | No |
| 2848 | 2261 | 1130.5 | 64.64 | 32.3 | Ageing and Parkinson's disease: substantia nigra regional selectivity. | J M Fearnley, A J Lees | Brain | 1991 | 1933245 | Yes |
| 2849 | 2261 | 1130.5 | 54.36 | 27.2 | Quorum sensing in bacteria. | M B Miller, B L Bassler | Annu Rev Microbiol | 2001 | 11544353 | No |
| 2850 | 1130 | 1130.0 | 41.23 | 41.2 | Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. | W A Catterall | Annu Rev Pharmacol Toxicol | 1980 | 6247957 | No |
| 2851 | 1130 | 1130.0 | 28.02 | 28.0 | Metabolism and functions of glutathione in brain. | R Dringen | Prog Neurobiol | 2000 | 10880854 | No |
| 2852 | 3389 | 1129.7 | 108.67 | 36.2 | MR diffusion tensor spectroscopy and imaging. | P J Basser, J Mattiello, D LeBihan | Biophys J | 1994 | 8130344 | Yes |
| 2853 | 3389 | 1129.7 | 78.2 | 26.1 | Hepatocellular carcinoma. | Josep M Llovet, Andrew Burroughs, Jordi Bruix | Lancet | 2003 | 14667750 | No |
| 2854 | 2259 | 1129.5 | 61.5 | 30.8 | Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. | M J Casadaban, S N Cohen | J Mol Biol | 1980 | 6997493 | Yes |
| 2855 | 1129 | 1129.0 | 33.9 | 33.9 | Unstable angina. A classification. | E Braunwald | Circulation | 1989 | 2752565 | Yes |
| 2856 | 1129 | 1129.0 | 33.9 | 33.9 | Determinants of tumor blood flow: a review. | R K Jain | Cancer Res | 1988 | 3282647 | No |
| 2857 | 1129 | 1129.0 | 0.0 | 0.0 | Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. | J Altman | J Comp Neurol | 1969 | 5361244 | Yes |
| 2858 | 1129 | 1129.0 | 0.0 | 0.0 | The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. | R E Hope-Simpson | Proc R Soc Med | 1965 | 14267505 | Yes |
| 2859 | 1129 | 1129.0 | 36.56 | 36.6 | Delirium in older persons. | Sharon K Inouye | N Engl J Med | 2006 | 16540616 | No |
| 2860 | 1129 | 1129.0 | 0.0 | 0.0 | Intra-sexual selection in Drosophila. | A J Bateman | Heredity (Edinb) | 1948 | 18103134 | Yes |
| 2861 | 2258 | 1129.0 | 118.19 | 59.1 | Parkinson's disease. | Lorraine V Kalia, Anthony E Lang | Lancet | 2015 | 25904081 | No |
| 2862 | 2256 | 1128.0 | 0.0 | 0.0 | Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. | H H Ussing, K Zerahn | Acta Physiol Scand | 1951 | 14868510 | Yes |
| 2863 | 3383 | 1127.7 | 92.59 | 30.9 | Bacterial biofilms: from the natural environment to infectious diseases. | Luanne Hall-Stoodley, J William Costerton, Paul Stoodley | Nat Rev Microbiol | 2004 | 15040259 | No |
| 2864 | 12403 | 1127.5 | 356.16 | 32.4 | The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. | Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristo | Genome Res | 2010 | 20644199 | Yes |
| 2865 | 2255 | 1127.5 | 112.26 | 56.1 | The Emerging Hallmarks of Cancer Metabolism. | Natalya N Pavlova, Craig B Thompson | Cell Metab | 2016 | 26771115 | No |
| 2866 | 1127 | 1127.0 | 31.01 | 31.0 | Diseases of the mitochondrial DNA. | D C Wallace | Annu Rev Biochem | 1992 | 1497308 | No |
| 2867 | 1127 | 1127.0 | 43.43 | 43.4 | On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. | D Collen | Thromb Haemost | 1980 | 6450468 | No |
| 2868 | 1127 | 1127.0 | 32.58 | 32.6 | The effects of stressful life events on depression. | R C Kessler | Annu Rev Psychol | 1997 | 9046559 | No |
| 2869 | 1127 | 1127.0 | 23.35 | 23.4 | Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. | Harold F Dvorak | J Clin Oncol | 2002 | 12409337 | No |
| 2870 | 1127 | 1127.0 | 0.0 | 0.0 | Voluntary strength and fatigue. | P A Merton | J Physiol | 1954 | 13152698 | Yes |
| 2871 | 1127 | 1127.0 | 0.0 | 0.0 | The relation of the trail making test to organic brain damage. | R M Reitan | J Consult Psychol | 1955 | 13263471 | Yes |
| 2872 | 1127 | 1127.0 | 30.84 | 30.8 | Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. | Paul Willner | Neuropsychobiology | 2005 | 16037678 | No |
| 2873 | 2253 | 1126.5 | 0.0 | 0.0 | Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. | L M Siegel, K J Monty | Biochim Biophys Acta | 1966 | 5329026 | Yes |
| 2874 | 2253 | 1126.5 | 53.58 | 26.8 | Cellular processing of platinum anticancer drugs. | Dong Wang, Stephen J Lippard | Nat Rev Drug Discov | 2005 | 15789122 | No |
| 2875 | 3379 | 1126.3 | 86.26 | 28.8 | Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. | Y Zhang, M Brady, S Smith | IEEE Trans Med Imaging | 2001 | 11293691 | Yes |
| 2876 | 1126 | 1126.0 | 28.71 | 28.7 | Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. | I J Fidler | Cancer Res | 1990 | 1698118 | Yes |
| 2877 | 1126 | 1126.0 | 32.92 | 32.9 | A Wilcoxon-type test for trend. | J Cuzick | Stat Med | 1985 | 3992076 | Yes |
| 2878 | 1126 | 1126.0 | 28.42 | 28.4 | Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. | Christof M Niemeyer | Angew Chem Int Ed Engl | 2001 | 29712109 | No |
| 2879 | 1126 | 1126.0 | 363.15 | 363.1 | COVID-19 and mental health: A review of the existing literature. | Ravi Philip Rajkumar | Asian J Psychiatr | 2020 | 32302935 | Yes |
| 2880 | 1125 | 1125.0 | 31.52 | 31.5 | Normalization of cell responses in cat striate cortex. | D J Heeger | Vis Neurosci | 1992 | 1504027 | Yes |
| 2881 | 1125 | 1125.0 | 22.28 | 22.3 | Regulation of transcription by MAP kinase cascades. | R Treisman | Curr Opin Cell Biol | 1996 | 8791420 | No |
| 2882 | 1125 | 1125.0 | 26.6 | 26.6 | Allelic discrimination using fluorogenic probes and the 5' nuclease assay. | K J Livak | Genet Anal | 1999 | 10084106 | Yes |
| 2883 | 1125 | 1125.0 | 22.11 | 22.1 | Microarray data normalization and transformation. | John Quackenbush | Nat Genet | 2002 | 12454644 | No |
| 2884 | 2250 | 1125.0 | 65.22 | 32.6 | Integrins in cancer: biological implications and therapeutic opportunities. | Jay S Desgrosellier, David A Cheresh | Nat Rev Cancer | 2010 | 20029421 | No |
| 2885 | 2249 | 1124.5 | 66.97 | 33.5 | Nitric oxide synthases in mammals. | R G Knowles, S Moncada | Biochem J | 1994 | 7510950 | No |
| 2886 | 7871 | 1124.4 | 161.79 | 23.1 | Exploration, normalization, and summaries of high density oligonucleotide array probe level data. | Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P Speed | Biostatistics | 2003 | 12925520 | Yes |
| 2887 | 1124 | 1124.0 | 30.4 | 30.4 | The chromosomal basis of human neoplasia. | J J Yunis | Science | 1983 | 6336310 | Yes |
| 2888 | 1124 | 1124.0 | 24.55 | 24.6 | An overview of epithelio-mesenchymal transformation. | E D Hay | Acta Anat (Basel) | 1995 | 8714286 | No |
| 2889 | 1124 | 1124.0 | 0.0 | 0.0 | Preliminary Trial Of Carisoprodol In Multiple Sclerosis. | B Ashworth | Practitioner | 1964 | 14143329 | Yes |
| 2890 | 2248 | 1124.0 | 62.66 | 31.3 | A neurotrophic model for stress-related mood disorders. | Ronald S Duman, Lisa M Monteggia | Biol Psychiatry | 2006 | 16631126 | No |
| 2891 | 2248 | 1124.0 | 69.72 | 34.9 | Natural products as sources of new drugs over the last 25 years. | David J Newman, Gordon M Cragg | J Nat Prod | 2007 | 17309302 | No |
| 2892 | 3371 | 1123.7 | 109.97 | 36.7 | Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. | B K Matuszewski, M L Constanzer, C M Chavez-Eng | Anal Chem | 2003 | 12964746 | Yes |
| 2893 | 2247 | 1123.5 | 51.19 | 25.6 | Adaptive protein evolution at the Adh locus in Drosophila. | J H McDonald, M Kreitman | Nature | 1991 | 1904993 | Yes |
| 2894 | 2247 | 1123.5 | 62.25 | 31.1 | EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. | Stefan Stoll, Arthur Schweiger | J Magn Reson | 2006 | 16188474 | Yes |
| 2895 | 2247 | 1123.5 | 111.88 | 55.9 | 3D bioprinting of tissues and organs. | Sean V Murphy, Anthony Atala | Nat Biotechnol | 2014 | 25093879 | Yes |
| 2896 | 1123 | 1123.0 | 105.02 | 105.0 | The analysis of errors in orthodontic measurements. | W J Houston | Am J Orthod | 1983 | 6573846 | Yes |
| 2897 | 1123 | 1123.0 | 33.75 | 33.8 | Reducing children's television viewing to prevent obesity: a randomized controlled trial. | T N Robinson | JAMA | 1999 | 10546696 | Yes |
| 2898 | 4488 | 1122.0 | 102.54 | 25.6 | Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. | J E Walker, M Saraste, M J Runswick, N J Gay | EMBO J | 1982 | 6329717 | Yes |
| 2899 | 2244 | 1122.0 | 67.72 | 33.9 | Physiological time-series analysis using approximate entropy and sample entropy. | J S Richman, J R Moorman | Am J Physiol Heart Circ Physiol | 2000 | 10843903 | Yes |
| 2900 | 2244 | 1122.0 | 44.15 | 22.1 | NF-kappaB at the crossroads of life and death. | Michael Karin, Anning Lin | Nat Immunol | 2002 | 11875461 | No |
| 2901 | 2244 | 1122.0 | 50.38 | 25.2 | Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. | S W Hell, J Wichmann | Opt Lett | 1994 | 19844443 | Yes |
| 2902 | 4486 | 1121.5 | 106.31 | 26.6 | Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. | G L Wang, B H Jiang, E A Rue, G L Semenza | Proc Natl Acad Sci U S A | 1995 | 7539918 | Yes |
| 2903 | 1121 | 1121.0 | 41.76 | 41.8 | The P300 wave of the human event-related potential. | T W Picton | J Clin Neurophysiol | 1992 | 1464675 | No |
| 2904 | 2242 | 1121.0 | 98.03 | 49.0 | Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. | P R Hunter, M A Gaston | J Clin Microbiol | 1988 | 3069867 | Yes |
| 2905 | 1121 | 1121.0 | 33.13 | 33.1 | Cell surface interactions with extracellular materials. | K M Yamada | Annu Rev Biochem | 1983 | 6351729 | No |
| 2906 | 2242 | 1121.0 | 72.59 | 36.3 | Modeling and comparison of dissolution profiles. | P Costa, J M Sousa Lobo | Eur J Pharm Sci | 2001 | 11297896 | No |
| 2907 | 2242 | 1121.0 | 56.09 | 28.0 | C-reactive protein: a critical update. | Mark B Pepys, Gideon M Hirschfield | J Clin Invest | 2003 | 12813013 | No |
| 2908 | 1121 | 1121.0 | 30.79 | 30.8 | Physiology and pathophysiology of purinergic neurotransmission. | Geoffrey Burnstock | Physiol Rev | 2007 | 17429044 | No |
| 2909 | 1121 | 1121.0 | 33.63 | 33.6 | Water as an active constituent in cell biology. | Philip Ball | Chem Rev | 2008 | 18095715 | No |
| 2910 | 4483 | 1120.8 | 104.65 | 26.2 | SCOP: a structural classification of proteins database for the investigation of sequences and structures. | A G Murzin, S E Brenner, T Hubbard, C Chothia | J Mol Biol | 1995 | 7723011 | Yes |
| 2911 | 3362 | 1120.7 | 78.32 | 26.1 | Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. | Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen | Science | 2005 | 15831717 | Yes |
| 2912 | 2238 | 1119.0 | 48.23 | 24.1 | NF-kappaB: linking inflammation and immunity to cancer development and progression. | Michael Karin, Florian R Greten | Nat Rev Immunol | 2005 | 16175180 | No |
| 2913 | 2236 | 1118.0 | 84.24 | 42.1 | Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. | H Esterbauer, K H Cheeseman | Methods Enzymol | 1990 | 2233308 | Yes |
| 2914 | 1118 | 1118.0 | 0.0 | 0.0 | A comparison of canal preparations in straight and curved root canals. | S W Schneider | Oral Surg Oral Med Oral Pathol | 1971 | 5284110 | Yes |
| 2915 | 6708 | 1118.0 | 232.4 | 38.7 | The occurrence of sleep-disordered breathing among middle-aged adults. | T Young, M Palta, J Dempsey, J Skatrud, S Weber, S Badr | N Engl J Med | 1993 | 8464434 | Yes |
| 2916 | 1117 | 1117.0 | 23.85 | 23.9 | Mutator phenotype may be required for multistage carcinogenesis. | L A Loeb | Cancer Res | 1991 | 2039987 | No |
| 2917 | 1117 | 1117.0 | 27.72 | 27.7 | Optical microcavities. | Kerry J Vahala | Nature | 2003 | 12917698 | Yes |
| 2918 | 1117 | 1117.0 | 26.73 | 26.7 | Evaluating medication effects outside of clinical trials: new-user designs. | Wayne A Ray | Am J Epidemiol | 2003 | 14585769 | Yes |
| 2919 | 1117 | 1117.0 | 27.66 | 27.7 | Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. | R Balfour Sartor | Nat Clin Pract Gastroenterol Hepatol | 2006 | 16819502 | No |
| 2920 | 2234 | 1117.0 | 51.2 | 25.6 | The canonical Notch signaling pathway: unfolding the activation mechanism. | Raphael Kopan, Maria Xenia G Ilagan | Cell | 2009 | 19379690 | No |
| 2921 | 2233 | 1116.5 | 47.93 | 24.0 | The mammalian unfolded protein response. | Martin Schröder, Randal J Kaufman | Annu Rev Biochem | 2005 | 15952902 | No |
| 2922 | 2232 | 1116.0 | 41.43 | 20.7 | Hedgehog signaling in animal development: paradigms and principles. | P W Ingham, A P McMahon | Genes Dev | 2001 | 11731473 | No |
| 2923 | 1116 | 1116.0 | 32.25 | 32.2 | Infection in solid-organ transplant recipients. | Jay A Fishman | N Engl J Med | 2007 | 18094380 | No |
| 2924 | 2230 | 1115.0 | 44.25 | 22.1 | Homeobox genes and axial patterning. | W McGinnis, R Krumlauf | Cell | 1992 | 1346368 | No |
| 2925 | 1115 | 1115.0 | 29.85 | 29.9 | The neurobiology of stress: from serendipity to clinical relevance. | B S McEwen | Brain Res | 2000 | 11119695 | No |
| 2926 | 1115 | 1115.0 | 23.42 | 23.4 | Apoptosis in neurodegenerative disorders. | M P Mattson | Nat Rev Mol Cell Biol | 2000 | 11253364 | No |
| 2927 | 1115 | 1115.0 | 0.0 | 0.0 | The powerful placebo. | H K Beecher | J Am Med Assoc | 1955 | 13271123 | Yes |
| 2928 | 1115 | 1115.0 | 36.69 | 36.7 | Persister cells. | Kim Lewis | Annu Rev Microbiol | 2010 | 20528688 | No |
| 2929 | 1114 | 1114.0 | 0.0 | 0.0 | Cytoprotection by prostaglandins. | A Robert | Gastroenterology | 1979 | 38173 | Yes |
| 2930 | 1114 | 1114.0 | 0.0 | 0.0 | Structure of chromatin. | R D Kornberg | Annu Rev Biochem | 1977 | 332067 | No |
| 2931 | 5570 | 1114.0 | 192.06 | 38.4 | Posttraumatic stress disorder in the National Comorbidity Survey. | R C Kessler, A Sonnega, E Bromet, M Hughes, C B Nelson | Arch Gen Psychiatry | 1995 | 7492257 | Yes |
| 2932 | 1114 | 1114.0 | 26.93 | 26.9 | Nonaqueous liquid electrolytes for lithium-based rechargeable batteries. | Kang Xu | Chem Rev | 2004 | 15669157 | Yes |
| 2933 | 1114 | 1114.0 | 29.95 | 29.9 | Functionalized acenes and heteroacenes for organic electronics. | John E Anthony | Chem Rev | 2006 | 17165682 | Yes |
| 2934 | 3340 | 1113.3 | 95.44 | 31.8 | Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. | Robert D Schreiber, Lloyd J Old, Mark J Smyth | Science | 2011 | 21436444 | No |
| 2935 | 1113 | 1113.0 | 0.0 | 0.0 | Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. | K Satoh | Clin Chim Acta | 1978 | 719890 | Yes |
| 2936 | 1113 | 1113.0 | 0.0 | 0.0 | Studies on histones. 7. Preparative methods for histone fractions from calf thymus. | E W Johns | Biochem J | 1964 | 5840387 | Yes |
| 2937 | 1113 | 1113.0 | 25.34 | 25.3 | Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. | M Kozak | Nucleic Acids Res | 1981 | 7301588 | Yes |
| 2938 | 1113 | 1113.0 | 23.6 | 23.6 | ALSCRIPT: a tool to format multiple sequence alignments. | G J Barton | Protein Eng | 1993 | 8433969 | Yes |
| 2939 | 4452 | 1113.0 | 126.57 | 31.6 | Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. | Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S Vasan | Stat Med | 2008 | 17569110 | Yes |
| 2940 | 2225 | 1112.5 | 46.32 | 23.2 | Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. | G A Gonzalez, M R Montminy | Cell | 1989 | 2573431 | Yes |
| 2941 | 2225 | 1112.5 | 54.74 | 27.4 | Cell cycle, CDKs and cancer: a changing paradigm. | Marcos Malumbres, Mariano Barbacid | Nat Rev Cancer | 2009 | 19238148 | No |
| 2942 | 1112 | 1112.0 | 42.0 | 42.0 | Omega-3 fatty acids in health and disease and in growth and development. | A P Simopoulos | Am J Clin Nutr | 1991 | 1908631 | No |
| 2943 | 1112 | 1112.0 | 0.0 | 0.0 | Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units. | C M Venkatachalam | Biopolymers | 1968 | 5685102 | Yes |
| 2944 | 1112 | 1112.0 | 31.21 | 31.2 | Pharmacology of cannabinoid CB1 and CB2 receptors. | R G Pertwee | Pharmacol Ther | 1997 | 9336020 | No |
| 2945 | 1112 | 1112.0 | 37.24 | 37.2 | Socioeconomic status and obesity. | Lindsay McLaren | Epidemiol Rev | 2007 | 17478442 | No |
| 2946 | 1112 | 1112.0 | 40.93 | 40.9 | AmpC beta-lactamases. | George A Jacoby | Clin Microbiol Rev | 2009 | 19136439 | No |
| 2947 | 1112 | 1112.0 | 29.32 | 29.3 | Recent advances in neuroblastoma. | John M Maris | N Engl J Med | 2010 | 20558371 | No |
| 2948 | 1112 | 1112.0 | 45.32 | 45.3 | The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. | Eleonore Fröhlich | Int J Nanomedicine | 2012 | 23144561 | No |
| 2949 | 2222 | 1111.0 | 43.06 | 21.5 | Dynamic instability of microtubule growth. | T Mitchison, M Kirschner | Nature | 1984 | 6504138 | Yes |
| 2950 | 1111 | 1111.0 | 43.43 | 43.4 | Molecular aspects of ligand binding to serum albumin. | U Kragh-Hansen | Pharmacol Rev | 1981 | 7027277 | No |
| 2951 | 2222 | 1111.0 | 274.63 | 137.3 | Interactive Tree Of Life (iTOL) v4: recent updates and new developments. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2019 | 30931475 | Yes |
| 2952 | 4442 | 1110.5 | 130.44 | 32.6 | Toxic potential of materials at the nanolevel. | Andre Nel, Tian Xia, Lutz Mädler, Ning Li | Science | 2006 | 16456071 | No |
| 2953 | 1110 | 1110.0 | 35.06 | 35.1 | Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. | J E Oesterling | J Urol | 1991 | 1707989 | No |
| 2954 | 1110 | 1110.0 | 34.75 | 34.8 | Protein damage and degradation by oxygen radicals. I. general aspects. | K J Davies | J Biol Chem | 1987 | 3036875 | Yes |
| 2955 | 2219 | 1109.5 | 0.0 | 0.0 | Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. | R J Britten, D E Kohne | Science | 1968 | 4874239 | Yes |
| 2956 | 2219 | 1109.5 | 119.55 | 59.8 | Making sense of Cronbach's alpha. | Mohsen Tavakol, Reg Dennick | Int J Med Educ | 2011 | 28029643 | No |
| 2957 | 6656 | 1109.3 | 204.15 | 34.0 | Free radicals and antioxidants in normal physiological functions and human disease. | Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua Telser | Int J Biochem Cell Biol | 2007 | 16978905 | No |
| 2958 | 2217 | 1108.5 | 69.06 | 34.5 | A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. | A Ennaceur, J Delacour | Behav Brain Res | 1988 | 3228475 | Yes |
| 2959 | 1108 | 1108.0 | 28.71 | 28.7 | Linkage strategies for genetically complex traits. I. Multilocus models. | N Risch | Am J Hum Genet | 1990 | 2301392 | Yes |
| 2960 | 2216 | 1108.0 | 49.05 | 24.5 | Prediction of protein secondary structure at better than 70% accuracy. | B Rost, C Sander | J Mol Biol | 1993 | 8345525 | Yes |
| 2961 | 1108 | 1108.0 | 39.22 | 39.2 | Density matrix formulation for quantum renormalization groups. | White | Phys Rev Lett | 1992 | 10046608 | Yes |
| 2962 | 1108 | 1108.0 | 31.05 | 31.1 | Leishmaniasis. | B L Herwaldt | Lancet | 1999 | 10513726 | No |
| 2963 | 1108 | 1108.0 | 37.81 | 37.8 | How stigma interferes with mental health care. | Patrick Corrigan | Am Psychol | 2004 | 15491256 | Yes |
| 2964 | 2215 | 1107.5 | 59.6 | 29.8 | Hydrogels for tissue engineering: scaffold design variables and applications. | Jeanie L Drury, David J Mooney | Biomaterials | 2003 | 12922147 | No |
| 2965 | 2215 | 1107.5 | 0.0 | 0.0 | Microdroplet Assay Of Human Serum Cytotoxins. | P I Terasaki, J D Mcclelland | Nature | 1964 | 14248725 | Yes |
| 2966 | 8860 | 1107.5 | 432.13 | 54.0 | The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. | Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jörg Peplies, Frank Oliver Glöckner | Nucleic Acids Res | 2013 | 23193283 | Yes |
| 2967 | 1107 | 1107.0 | 36.13 | 36.1 | Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. | Ronald A Hites | Environ Sci Technol | 2004 | 14998004 | Yes |
| 2968 | 1107 | 1107.0 | 0.0 | 0.0 | Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. | P B Medawar | Br J Exp Pathol | 1948 | 18865105 | Yes |
| 2969 | 1107 | 1107.0 | 35.4 | 35.4 | Deconvoluting the context-dependent role for autophagy in cancer. | Eileen White | Nat Rev Cancer | 2012 | 22534666 | No |
| 2970 | 2213 | 1106.5 | 71.25 | 35.6 | Excitatory amino acid transmitters. | J C Watkins, R H Evans | Annu Rev Pharmacol Toxicol | 1981 | 6112965 | No |
| 2971 | 2213 | 1106.5 | 84.42 | 42.2 | Functional interactions between the gut microbiota and host metabolism. | Valentina Tremaroli, Fredrik Bäckhed | Nature | 2012 | 22972297 | No |
| 2972 | 1106 | 1106.0 | 37.75 | 37.8 | Chemoprevention of cancer. | L W Wattenberg | Cancer Res | 1985 | 3880665 | No |
| 2973 | 1106 | 1106.0 | 21.28 | 21.3 | Regulation of phosphoinositide-specific phospholipase C. | S G Rhee | Annu Rev Biochem | 2001 | 11395409 | No |
| 2974 | 2212 | 1106.0 | 61.57 | 30.8 | Biology of incretins: GLP-1 and GIP. | Laurie L Baggio, Daniel J Drucker | Gastroenterology | 2007 | 17498508 | No |
| 2975 | 2211 | 1105.5 | 66.54 | 33.3 | Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. | Taro Kawai, Shizuo Akira | Immunity | 2011 | 21616434 | No |
| 2976 | 1105 | 1105.0 | 27.2 | 27.2 | Plant salt tolerance. | J K Zhu | Trends Plant Sci | 2001 | 11173290 | Yes |
| 2977 | 1105 | 1105.0 | 0.0 | 0.0 | A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. | M G Buonocore | J Dent Res | 1955 | 13271655 | Yes |
| 2978 | 1105 | 1105.0 | 38.62 | 38.6 | The epidemiology of adult obstructive sleep apnea. | Naresh M Punjabi | Proc Am Thorac Soc | 2008 | 18250205 | No |
| 2979 | 1105 | 1105.0 | 0.0 | 0.0 | Knee joint changes after meniscectomy. | T J Fairbank | J Bone Joint Surg Br | 1948 | 18894618 | Yes |
| 2980 | 1105 | 1105.0 | 38.72 | 38.7 | Thermal properties of graphene and nanostructured carbon materials. | Alexander A Balandin | Nat Mater | 2011 | 21778997 | Yes |
| 2981 | 3313 | 1104.3 | 0.0 | 0.0 | Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. | M Hamberg, J Svensson, B Samuelsson | Proc Natl Acad Sci U S A | 1975 | 1059088 | Yes |
| 2982 | 2208 | 1104.0 | 0.0 | 0.0 | Construction of phylogenetic trees. | W M Fitch, E Margoliash | Science | 1967 | 5334057 | No |
| 2983 | 1104 | 1104.0 | 34.89 | 34.9 | Strategies of antioxidant defense. | H Sies | Eur J Biochem | 1993 | 7688300 | No |
| 2984 | 2208 | 1104.0 | 0.0 | 0.0 | Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. | A H Coons, M H Kaplan | J Exp Med | 1950 | 15395569 | Yes |
| 2985 | 2207 | 1103.5 | 77.4 | 38.7 | The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. | G P Chrousos, P W Gold | JAMA | 1992 | 1538563 | No |
| 2986 | 4412 | 1103.0 | 0.0 | 0.0 | Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. | L A Papile, J Burstein, R Burstein, H Koffler | J Pediatr | 1978 | 305471 | Yes |
| 2987 | 1103 | 1103.0 | 22.46 | 22.5 | Primary response genes induced by growth factors and tumor promoters. | H R Herschman | Annu Rev Biochem | 1991 | 1883198 | No |
| 2988 | 1103 | 1103.0 | 34.35 | 34.4 | Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. | M E Bouton | Psychol Bull | 1993 | 8346330 | No |
| 2989 | 1103 | 1103.0 | 0.0 | 0.0 | A cytoarchitectonic atlas of the spinal cord in the cat. | B Rexed | J Comp Neurol | 1954 | 13163236 | Yes |
| 2990 | 1103 | 1103.0 | 0.0 | 0.0 | The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. | J Vague | Am J Clin Nutr | 1956 | 13282851 | Yes |
| 2991 | 1103 | 1103.0 | 38.4 | 38.4 | Amino acids: metabolism, functions, and nutrition. | Guoyao Wu | Amino Acids | 2009 | 19301095 | No |
| 2992 | 2205 | 1102.5 | 60.0 | 30.0 | Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. | R A Ignotz, J Massagué | J Biol Chem | 1986 | 3456347 | Yes |
| 2993 | 1102 | 1102.0 | 0.0 | 0.0 | The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion. | S Roseman | Chem Phys Lipids | 1970 | 5476326 | Yes |
| 2994 | 1102 | 1102.0 | 37.54 | 37.5 | Selective attention and the organization of visual information. | J Duncan | J Exp Psychol Gen | 1984 | 6240521 | Yes |
| 2995 | 1102 | 1102.0 | 23.05 | 23.1 | Differentiation and proliferation of hematopoietic stem cells. | M Ogawa | Blood | 1993 | 8499622 | No |
| 2996 | 1102 | 1102.0 | 22.23 | 22.2 | A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. | Xuemei Chen | Science | 2004 | 12893888 | Yes |
| 2997 | 3306 | 1102.0 | 182.66 | 60.9 | Fast and sensitive protein alignment using DIAMOND. | Benjamin Buchfink, Chao Xie, Daniel H Huson | Nat Methods | 2015 | 25402007 | Yes |
| 2998 | 2203 | 1101.5 | 0.0 | 0.0 | Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. | A Warshel, M Levitt | J Mol Biol | 1976 | 985660 | Yes |
| 2999 | 1101 | 1101.0 | 24.77 | 24.8 | The molecular biology of leukocyte chemoattractant receptors. | P M Murphy | Annu Rev Immunol | 1994 | 8011292 | No |
| 3000 | 1101 | 1101.0 | 24.35 | 24.4 | Assortative mixing in networks. | M E J Newman | Phys Rev Lett | 2002 | 12443515 | Yes |
| 3001 | 1101 | 1101.0 | 46.9 | 46.9 | What is self-rated health and why does it predict mortality? Towards a unified conceptual model. | Marja Jylhä | Soc Sci Med | 2009 | 19520474 | Yes |
| 3002 | 2202 | 1101.0 | 73.12 | 36.6 | Extended-connectivity fingerprints. | David Rogers, Mathew Hahn | J Chem Inf Model | 2010 | 20426451 | Yes |
| 3003 | 2202 | 1101.0 | 66.05 | 33.0 | Tumor metastasis: molecular insights and evolving paradigms. | Scott Valastyan, Robert A Weinberg | Cell | 2011 | 22000009 | No |
| 3004 | 4403 | 1100.8 | 89.05 | 22.3 | Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. | L Alexopoulou, A C Holt, R Medzhitov, R A Flavell | Nature | 2001 | 11607032 | Yes |
| 3005 | 3301 | 1100.3 | 72.35 | 24.1 | A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. | M Serrano, G J Hannon, D Beach | Nature | 1993 | 8259215 | Yes |
| 3006 | 1100 | 1100.0 | 0.0 | 0.0 | Sex-hormone-binding globulin. | D C Anderson | Clin Endocrinol (Oxf) | 1974 | 4134992 | No |
| 3007 | 1100 | 1100.0 | 0.0 | 0.0 | Inherited Antithrombin Deficiency Causing Thrombophilia. | O Egeberg | Thromb Diath Haemorrh | 1965 | 14347873 | Yes |
| 3008 | 1100 | 1100.0 | 0.0 | 0.0 | Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins. | R D Owen | Science | 1945 | 17755278 | Yes |
| 3009 | 2200 | 1100.0 | 95.9 | 48.0 | Methods for the thematic synthesis of qualitative research in systematic reviews. | James Thomas, Angela Harden | BMC Med Res Methodol | 2008 | 18616818 | Yes |
| 3010 | 2199 | 1099.5 | 65.42 | 32.7 | Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. | P Brugada, J Brugada | J Am Coll Cardiol | 1992 | 1309182 | Yes |
| 3011 | 4397 | 1099.2 | 119.58 | 29.9 | Prevalence and trends in obesity among US adults, 1999-2000. | Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L Johnson | JAMA | 2002 | 12365955 | Yes |
| 3012 | 1099 | 1099.0 | 21.01 | 21.0 | Luciferase reporter gene vectors for analysis of promoters and enhancers. | S K Nordeen | Biotechniques | 1988 | 2908509 | Yes |
| 3013 | 1099 | 1099.0 | 37.88 | 37.9 | beta-Lactamases in laboratory and clinical resistance. | D M Livermore | Clin Microbiol Rev | 1995 | 8665470 | No |
| 3014 | 1099 | 1099.0 | 28.86 | 28.9 | Disorders of iron metabolism. | N C Andrews | N Engl J Med | 1999 | 10607817 | No |
| 3015 | 1099 | 1099.0 | 20.49 | 20.5 | The development of neural stem cells. | S Temple | Nature | 2001 | 11689956 | No |
| 3016 | 1098 | 1098.0 | 39.43 | 39.4 | Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. | J N Wasserheit | Sex Transm Dis | 1992 | 1595015 | No |
| 3017 | 1098 | 1098.0 | 21.83 | 21.8 | Cytokine receptor signalling. | J N Ihle | Nature | 1995 | 7566171 | No |
| 3018 | 1098 | 1098.0 | 25.58 | 25.6 | Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. | H J Dargie | Lancet | 2001 | 11356434 | Yes |
| 3019 | 1098 | 1098.0 | 32.44 | 32.4 | Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. | P Vestergaard | Osteoporos Int | 2007 | 17068657 | No |
| 3020 | 1098 | 1098.0 | 30.86 | 30.9 | Persister cells, dormancy and infectious disease. | Kim Lewis | Nat Rev Microbiol | 2007 | 17143318 | No |
| 3021 | 2196 | 1098.0 | 72.79 | 36.4 | Plasmonics for improved photovoltaic devices. | Harry A Atwater, Albert Polman | Nat Mater | 2010 | 20168344 | Yes |
| 3022 | 2195 | 1097.5 | 58.11 | 29.1 | Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. | Subhra K Biswas, Alberto Mantovani | Nat Immunol | 2010 | 20856220 | No |
| 3023 | 1097 | 1097.0 | 33.25 | 33.2 | A human model of gastric carcinogenesis. | P Correa | Cancer Res | 1988 | 3288329 | No |
| 3024 | 1097 | 1097.0 | 44.03 | 44.0 | Freezing of living cells: mechanisms and implications. | P Mazur | Am J Physiol | 1984 | 6383068 | No |
| 3025 | 2193 | 1096.5 | 56.78 | 28.4 | Statistical tests of neutrality of mutations. | Y X Fu, W H Li | Genetics | 1993 | 8454210 | Yes |
| 3026 | 1096 | 1096.0 | 27.6 | 27.6 | Tumour necrosis factor and cancer. | Frances Balkwill | Nat Rev Cancer | 2009 | 19343034 | No |
| 3027 | 1096 | 1096.0 | 51.78 | 51.8 | Modeling Development and Disease with Organoids. | Hans Clevers | Cell | 2016 | 27315476 | No |
| 3028 | 2192 | 1096.0 | 134.98 | 67.5 | MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. | Rajesha Rupaimoole, Frank J Slack | Nat Rev Drug Discov | 2017 | 28209991 | No |
| 3029 | 2191 | 1095.5 | 73.88 | 36.9 | Physiological parameters in laboratory animals and humans. | B Davies, T Morris | Pharm Res | 1993 | 8378254 | No |
| 3030 | 1095 | 1095.0 | 43.83 | 43.8 | Geriatric Depression Scale. | J A Yesavage | Psychopharmacol Bull | 1988 | 3249773 | Yes |
| 3031 | 1095 | 1095.0 | 27.99 | 28.0 | Two distinct classes of carbohydrate-recognition domains in animal lectins. | K Drickamer | J Biol Chem | 1988 | 3290208 | No |
| 3032 | 1095 | 1095.0 | 32.34 | 32.3 | Cholesterol and the cell membrane. | P L Yeagle | Biochim Biophys Acta | 1985 | 3904832 | No |
| 3033 | 1095 | 1095.0 | 30.44 | 30.4 | Venous thrombosis: a multicausal disease. | F R Rosendaal | Lancet | 1999 | 10209995 | No |
| 3034 | 1095 | 1095.0 | 25.38 | 25.4 | G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. | Jeffery T Davis | Angew Chem Int Ed Engl | 2004 | 14755695 | No |
| 3035 | 1095 | 1095.0 | 22.37 | 22.4 | Inferences, questions and possibilities in Toll-like receptor signalling. | Bruce Beutler | Nature | 2004 | 15241424 | No |
| 3036 | 2190 | 1095.0 | 69.49 | 34.7 | Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. | S Geman, D Geman | IEEE Trans Pattern Anal Mach Intell | 1984 | 22499653 | Yes |
| 3037 | 2189 | 1094.5 | 54.52 | 27.3 | Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. | M E Feder, G E Hofmann | Annu Rev Physiol | 1999 | 10099689 | No |
| 3038 | 2189 | 1094.5 | 75.89 | 37.9 | LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. | Roman A Laskowski, Mark B Swindells | J Chem Inf Model | 2011 | 21919503 | Yes |
| 3039 | 1094 | 1094.0 | 42.12 | 42.1 | The role of endothelium in the responses of vascular smooth muscle to drugs. | R F Furchgott | Annu Rev Pharmacol Toxicol | 1984 | 6203480 | No |
| 3040 | 1094 | 1094.0 | 21.89 | 21.9 | Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. | A S Baldwin | J Clin Invest | 2001 | 11160144 | No |
| 3041 | 2188 | 1094.0 | 52.08 | 26.0 | Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. | Jing Yang, Robert A Weinberg | Dev Cell | 2008 | 18539112 | No |
| 3042 | 2187 | 1093.5 | 49.53 | 24.8 | Defining the role of mTOR in cancer. | David A Guertin, David M Sabatini | Cancer Cell | 2007 | 17613433 | No |
| 3043 | 5467 | 1093.4 | 272.8 | 54.6 | Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. | N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W Stitt | J Rheumatol | 1988 | 3068365 | Yes |
| 3044 | 1093 | 1093.0 | 23.13 | 23.1 | A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. | J Milbrandt | Science | 1987 | 3672127 | Yes |
| 3045 | 1093 | 1093.0 | 46.75 | 46.8 | A spreading-activation theory of retrieval in sentence production. | G S Dell | Psychol Rev | 1986 | 3749399 | Yes |
| 3046 | 1093 | 1093.0 | 34.0 | 34.0 | The somatic marker hypothesis and the possible functions of the prefrontal cortex. | A R Damasio | Philos Trans R Soc Lond B Biol Sci | 1996 | 8941953 | No |
| 3047 | 1093 | 1093.0 | 21.57 | 21.6 | The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. | Y Yarden | Eur J Cancer | 2001 | 11597398 | No |
| 3048 | 2186 | 1093.0 | 77.64 | 38.8 | Origins and evolution of antibiotic resistance. | Julian Davies, Dorothy Davies | Microbiol Mol Biol Rev | 2010 | 20805405 | No |
| 3049 | 2184 | 1092.0 | 46.2 | 23.1 | Sequence logos: a new way to display consensus sequences. | T D Schneider, R M Stephens | Nucleic Acids Res | 1990 | 2172928 | Yes |
| 3050 | 1092 | 1092.0 | 23.82 | 23.8 | Fluorescence spectroscopy of single biomolecules. | S Weiss | Science | 1999 | 10073925 | No |
| 3051 | 1092 | 1092.0 | 38.92 | 38.9 | Electrocatalyst approaches and challenges for automotive fuel cells. | Mark K Debe | Nature | 2012 | 22678278 | Yes |
| 3052 | 2183 | 1091.5 | 53.35 | 26.7 | Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. | Josep M Llovet, Jordi Bruix | Hepatology | 2003 | 12540794 | No |
| 3053 | 1091 | 1091.0 | 32.99 | 33.0 | Analyzing the mosaic structure of genes. | J M Smith | J Mol Evol | 1992 | 1556748 | No |
| 3054 | 2182 | 1091.0 | 44.21 | 22.1 | RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. | M B Shapiro, P Senapathy | Nucleic Acids Res | 1987 | 3658675 | Yes |
| 3055 | 1091 | 1091.0 | 26.34 | 26.3 | Molecular drive: a cohesive mode of species evolution. | G Dover | Nature | 1982 | 7110332 | Yes |
| 3056 | 1091 | 1091.0 | 24.7 | 24.7 | The myofibroblast in wound healing and fibrocontractive diseases. | G Gabbiani | J Pathol | 2003 | 12845617 | No |
| 3057 | 1091 | 1091.0 | 0.0 | 0.0 | The purine and pyrimidine composition of deoxypentose nucleic acids. | G R Wyatt | Biochem J | 1951 | 14838906 | Yes |
| 3058 | 1091 | 1091.0 | 38.96 | 39.0 | Tumor delivery of macromolecular drugs based on the EPR effect. | Vladimir Torchilin | Adv Drug Deliv Rev | 2011 | 20304019 | No |
| 3059 | 2181 | 1090.5 | 58.48 | 29.2 | Oxidative stress, caloric restriction, and aging. | R S Sohal, R Weindruch | Science | 1996 | 8658196 | No |
| 3060 | 1090 | 1090.0 | 0.0 | 0.0 | Corticosteroids and lymphoid cells. | H N Claman | N Engl J Med | 1972 | 5043524 | Yes |
| 3061 | 1090 | 1090.0 | 21.56 | 21.6 | The power and the promise of DNA methylation markers. | Peter W Laird | Nat Rev Cancer | 2003 | 12671664 | No |
| 3062 | 1090 | 1090.0 | 0.0 | 0.0 | Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. | R M Berne | Am J Physiol | 1963 | 13971060 | Yes |
| 3063 | 1090 | 1090.0 | 34.8 | 34.8 | Platelet-rich plasma: evidence to support its use. | Robert E Marx | J Oral Maxillofac Surg | 2004 | 15085519 | No |
| 3064 | 3269 | 1089.7 | 78.12 | 26.0 | Photodynamic therapy for cancer. | Dennis E J G J Dolmans, Dai Fukumura, Rakesh K Jain | Nat Rev Cancer | 2003 | 12724736 | No |
| 3065 | 2179 | 1089.5 | 75.85 | 37.9 | Pharmaceuticals and personal care products in the environment: agents of subtle change? | C G Daughton, T A Ternes | Environ Health Perspect | 1999 | 10592150 | No |
| 3066 | 1089 | 1089.0 | 25.32 | 25.3 | Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. | Michael J Sanderson | Mol Biol Evol | 2002 | 11752195 | Yes |
| 3067 | 1088 | 1088.0 | 23.02 | 23.0 | T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. | R H Schwartz | Annu Rev Immunol | 1985 | 2415139 | No |
| 3068 | 1088 | 1088.0 | 32.4 | 32.4 | Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. | M J Gasson | J Bacteriol | 1983 | 6403500 | Yes |
| 3069 | 1088 | 1088.0 | 37.07 | 37.1 | Checklists for improving rigour in qualitative research: a case of the tail wagging the dog? | R S Barbour | BMJ | 2001 | 11337448 | No |
| 3070 | 2176 | 1088.0 | 0.0 | 0.0 | Micromethod for the direct determination of serum triglycerides. | E Van Handel, D B Zilversmit | J Lab Clin Med | 1957 | 13439279 | Yes |
| 3071 | 1088 | 1088.0 | 28.36 | 28.4 | Electrochemiluminescence (ECL). | Mark M Richter | Chem Rev | 2004 | 15186186 | No |
| 3072 | 1087 | 1087.0 | 26.53 | 26.5 | A tension-based theory of morphogenesis and compact wiring in the central nervous system. | D C Van Essen | Nature | 1997 | 9002514 | Yes |
| 3073 | 2173 | 1086.5 | 56.08 | 28.0 | Hydrogels for tissue engineering. | K Y Lee, D J Mooney | Chem Rev | 2001 | 11710233 | No |
| 3074 | 2173 | 1086.5 | 0.0 | 0.0 | A revision of the Schoenheimer-Sperry method for cholesterol determination. | W M Sperry, M Webb | J Biol Chem | 1950 | 14794694 | Yes |
| 3075 | 1086 | 1086.0 | 27.94 | 27.9 | Selectins: interpreters of cell-specific carbohydrate information during inflammation. | L A Lasky | Science | 1992 | 1439808 | No |
| 3076 | 1086 | 1086.0 | 42.66 | 42.7 | Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. | J T Daugirdas | J Am Soc Nephrol | 1993 | 8305648 | Yes |
| 3077 | 1086 | 1086.0 | 0.0 | 0.0 | Cleavage of the haem-protein link by acid methylethylketone. | F W Teale | Biochim Biophys Acta | 1959 | 13837237 | Yes |
| 3078 | 2172 | 1086.0 | 65.91 | 33.0 | Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. | Xiaobo Chen, Samuel S Mao | Chem Rev | 2007 | 17590053 | Yes |
| 3079 | 2171 | 1085.5 | 66.06 | 33.0 | Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. | Aluísio J D Barros, Vânia N Hirakata | BMC Med Res Methodol | 2003 | 14567763 | Yes |
| 3080 | 1085 | 1085.0 | 32.8 | 32.8 | What is synergy? | M C Berenbaum | Pharmacol Rev | 1989 | 2692037 | No |
| 3081 | 2170 | 1085.0 | 50.1 | 25.1 | Esophageal cancer. | Peter C Enzinger, Robert J Mayer | N Engl J Med | 2003 | 14657432 | No |
| 3082 | 1085 | 1085.0 | 25.71 | 25.7 | Next-generation DNA sequencing methods. | Elaine R Mardis | Annu Rev Genomics Hum Genet | 2008 | 18576944 | No |
| 3083 | 2168 | 1084.0 | 74.1 | 37.0 | Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. | A E Czeizel, I Dudás | N Engl J Med | 1992 | 1307234 | Yes |
| 3084 | 1084 | 1084.0 | 25.78 | 25.8 | Neurons with graded response have collective computational properties like those of two-state neurons. | J J Hopfield | Proc Natl Acad Sci U S A | 1984 | 6587342 | Yes |
| 3085 | 1084 | 1084.0 | 19.09 | 19.1 | Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. | M S Wold | Annu Rev Biochem | 1997 | 9242902 | No |
| 3086 | 1084 | 1084.0 | 28.96 | 29.0 | The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. | R A Jain | Biomaterials | 2000 | 11055295 | No |
| 3087 | 1084 | 1084.0 | 22.77 | 22.8 | Liver regeneration: from myth to mechanism. | Rebecca Taub | Nat Rev Mol Cell Biol | 2004 | 15459664 | No |
| 3088 | 1084 | 1084.0 | 24.1 | 24.1 | Version 1.2 of the Crystallography and NMR system. | Axel T Brunger | Nat Protoc | 2007 | 18007608 | Yes |
| 3089 | 1084 | 1084.0 | 0.0 | 0.0 | Aniline hydrogen phthalate as a spraying reagent for chromatography of sugars. | S M Partridge | Nature | 1949 | 18140444 | Yes |
| 3090 | 2167 | 1083.5 | 42.91 | 21.5 | Rho GTPases: biochemistry and biology. | Aron B Jaffe, Alan Hall | Annu Rev Cell Dev Biol | 2005 | 16212495 | No |
| 3091 | 1083 | 1083.0 | 27.79 | 27.8 | Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. | M J Berridge | Biochem J | 1983 | 6309155 | Yes |
| 3092 | 2166 | 1083.0 | 76.74 | 38.4 | Social conditions as fundamental causes of disease. | B G Link, J Phelan | J Health Soc Behav | 1995 | 7560851 | No |
| 3093 | 1083 | 1083.0 | 34.28 | 34.3 | The oxidation hypothesis of atherosclerosis. | J L Witztum | Lancet | 1994 | 7916078 | No |
| 3094 | 2166 | 1083.0 | 50.94 | 25.5 | Shape-controlled synthesis of gold and silver nanoparticles. | Yugang Sun, Younan Xia | Science | 2002 | 12481134 | Yes |
| 3095 | 1083 | 1083.0 | 0.0 | 0.0 | A New Serum Type System In Man--The Lp System. | K Berg | Acta Pathol Microbiol Scand | 1963 | 14064818 | Yes |
| 3096 | 1083 | 1083.0 | 47.66 | 47.7 | The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults. | L S Radloff | J Youth Adolesc | 1991 | 24265004 | Yes |
| 3097 | 2165 | 1082.5 | 45.59 | 22.8 | p53: puzzle and paradigm. | L J Ko, C Prives | Genes Dev | 1996 | 8654922 | No |
| 3098 | 1082 | 1082.0 | 34.66 | 34.7 | Relations between the statistics of natural images and the response properties of cortical cells. | D J Field | J Opt Soc Am A | 1987 | 3430225 | Yes |
| 3099 | 2164 | 1082.0 | 66.38 | 33.2 | 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. | A Poland, J C Knutson | Annu Rev Pharmacol Toxicol | 1982 | 6282188 | No |
| 3100 | 1082 | 1082.0 | 0.0 | 0.0 | The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs. | M Vogt | J Physiol | 1954 | 13152692 | Yes |
| 3101 | 1082 | 1082.0 | 33.34 | 33.3 | Electrochemical glucose biosensors. | Joseph Wang | Chem Rev | 2008 | 18154363 | No |
| 3102 | 2164 | 1082.0 | 69.63 | 34.8 | Chronic hepatitis B: update 2009. | Anna S F Lok, Brian J McMahon | Hepatology | 2009 | 19714720 | Yes |
| 3103 | 4325 | 1081.2 | 144.01 | 36.0 | The cholinergic hypothesis of geriatric memory dysfunction. | R T Bartus, R L Dean, B Beer, A S Lippa | Science | 1982 | 7046051 | No |
| 3104 | 2162 | 1081.0 | 0.0 | 0.0 | Peroxidase-labeled antibody. A new method of conjugation. | P K Nakane, A Kawaoi | J Histochem Cytochem | 1974 | 4443551 | Yes |
| 3105 | 1081 | 1081.0 | 23.42 | 23.4 | Nucleic acid junctions and lattices. | N C Seeman | J Theor Biol | 1982 | 6188926 | Yes |
| 3106 | 2162 | 1081.0 | 48.83 | 24.4 | Cell cycle control and cancer. | L H Hartwell, M B Kastan | Science | 1994 | 7997877 | No |
| 3107 | 2162 | 1081.0 | 56.79 | 28.4 | Protein oxidation in aging, disease, and oxidative stress. | B S Berlett, E R Stadtman | J Biol Chem | 1997 | 9252331 | No |
| 3108 | 1081 | 1081.0 | 21.88 | 21.9 | VEGF and the quest for tumour angiogenesis factors. | Napoleone Ferrara | Nat Rev Cancer | 2002 | 12360282 | No |
| 3109 | 1081 | 1081.0 | 0.0 | 0.0 | Fertilizing capacity of spermatozoa deposited into the fallopian tubes. | M C Chang | Nature | 1951 | 14882325 | Yes |
| 3110 | 1081 | 1081.0 | 35.7 | 35.7 | Understanding diagnostic tests 3: Receiver operating characteristic curves. | Anthony K Akobeng | Acta Paediatr | 2007 | 17376185 | No |
| 3111 | 3242 | 1080.7 | 121.99 | 40.7 | Hepatocellular carcinoma. | Alejandro Forner, Josep M Llovet, Jordi Bruix | Lancet | 2012 | 22353262 | No |
| 3112 | 1080 | 1080.0 | 27.93 | 27.9 | Comparative physiology of salt and water stress. | R. Munns | Plant Cell Environ | 2002 | 11841667 | Yes |
| 3113 | 1080 | 1080.0 | 0.0 | 0.0 | Asymptomatic infections of the urinary tract. | E H Kass | Trans Assoc Am Physicians | 1956 | 13380946 | Yes |
| 3114 | 4320 | 1080.0 | 0.0 | 0.0 | The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. | P J Randle, P B Garland, C N Hales, E A Newsholme | Lancet | 1963 | 13990765 | Yes |
| 3115 | 1080 | 1080.0 | 33.04 | 33.0 | Species concepts and species delimitation. | Kevin De Queiroz | Syst Biol | 2007 | 18027281 | Yes |
| 3116 | 1079 | 1079.0 | 41.92 | 41.9 | A new international staging system for lung cancer. | C F Mountain | Chest | 1986 | 3514171 | No |
| 3117 | 1079 | 1079.0 | 0.0 | 0.0 | A teacher rating scale for use in drug studies with children. | C K Conners | Am J Psychiatry | 1969 | 4900822 | Yes |
| 3118 | 1079 | 1079.0 | 0.0 | 0.0 | Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities. | F Fonnum | Biochem J | 1969 | 4982085 | Yes |
| 3119 | 1079 | 1079.0 | 27.19 | 27.2 | The Trk family of neurotrophin receptors. | M Barbacid | J Neurobiol | 1994 | 7852993 | No |
| 3120 | 1079 | 1079.0 | 40.21 | 40.2 | Volumetric modulated arc therapy: IMRT in a single gantry arc. | Karl Otto | Med Phys | 2008 | 18293586 | Yes |
| 3121 | 2157 | 1078.5 | 0.0 | 0.0 | Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques. | P Gold, S O Freedman | J Exp Med | 1965 | 14270243 | Yes |
| 3122 | 1078 | 1078.0 | 37.67 | 37.7 | Multiple organ failure. Pathophysiology and potential future therapy. | E A Deitch | Ann Surg | 1992 | 1503516 | No |
| 3123 | 1078 | 1078.0 | 40.12 | 40.1 | Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants. | R W Bohannon | Age Ageing | 1997 | 9143432 | Yes |
| 3124 | 3233 | 1077.7 | 105.91 | 35.3 | Qualitative research in health care. Analysing qualitative data. | C Pope, S Ziebland, N Mays | BMJ | 2000 | 10625273 | No |
| 3125 | 2155 | 1077.5 | 55.1 | 27.6 | Principles of bioactive lipid signalling: lessons from sphingolipids. | Yusuf A Hannun, Lina M Obeid | Nat Rev Mol Cell Biol | 2008 | 18216770 | No |
| 3126 | 1077 | 1077.0 | 31.05 | 31.1 | Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. | T Feizi | Nature | 1985 | 2579340 | Yes |
| 3127 | 1077 | 1077.0 | 0.0 | 0.0 | A kinetic photometric method for serum gamma-glutamyl transpeptidase. | G Szasz | Clin Chem | 1969 | 5773262 | Yes |
| 3128 | 1077 | 1077.0 | 0.0 | 0.0 | Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. | G D Winter | Nature | 1962 | 14007593 | Yes |
| 3129 | 1077 | 1077.0 | 54.03 | 54.0 | Mechanisms linking social ties and support to physical and mental health. | Peggy A Thoits | J Health Soc Behav | 2011 | 21673143 | No |
| 3130 | 1077 | 1077.0 | 67.72 | 67.7 | Hydrogel: Preparation, characterization, and applications: A review. | Enas M Ahmed | J Adv Res | 2015 | 25750745 | No |
| 3131 | 4307 | 1076.8 | 107.34 | 26.8 | C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. | P M Ridker, C H Hennekens, J E Buring, N Rifai | N Engl J Med | 2000 | 10733371 | Yes |
| 3132 | 2152 | 1076.0 | 0.0 | 0.0 | T antigen is bound to a host protein in SV40-transformed cells. | D P Lane, L V Crawford | Nature | 1979 | 218111 | Yes |
| 3133 | 1076 | 1076.0 | 29.74 | 29.7 | Aging, energy, and oxidative stress in neurodegenerative diseases. | M F Beal | Ann Neurol | 1995 | 7668820 | No |
| 3134 | 2152 | 1076.0 | 47.7 | 23.9 | Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. | T Hunter, J Pines | Cell | 1994 | 7954824 | No |
| 3135 | 1076 | 1076.0 | 30.25 | 30.2 | Thermo- and pH-responsive polymers in drug delivery. | Dirk Schmaljohann | Adv Drug Deliv Rev | 2006 | 17125884 | No |
| 3136 | 6456 | 1076.0 | 171.98 | 28.7 | An obesity-associated gut microbiome with increased capacity for energy harvest. | Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I Gordon | Nature | 2006 | 17183312 | Yes |
| 3137 | 6452 | 1075.3 | 142.52 | 23.8 | Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. | D A Melton, P A Krieg, M R Rebagliati, T Maniatis, K Zinn, M R Green | Nucleic Acids Res | 1984 | 6091052 | Yes |
| 3138 | 1075 | 1075.0 | 22.69 | 22.7 | Protein tyrosine phosphatases: from genes, to function, to disease. | Nicholas K Tonks | Nat Rev Mol Cell Biol | 2006 | 17057753 | No |
| 3139 | 2149 | 1074.5 | 68.84 | 34.4 | Glutamate and the pathophysiology of hypoxic--ischemic brain damage. | S M Rothman, J W Olney | Ann Neurol | 1986 | 2421636 | No |
| 3140 | 2149 | 1074.5 | 44.52 | 22.3 | A survey of telomerase activity in human cancer. | J W Shay, S Bacchetti | Eur J Cancer | 1997 | 9282118 | No |
| 3141 | 1074 | 1074.0 | 0.0 | 0.0 | Time-dependent processes in memory storage. | J L McGaugh | Science | 1966 | 5917768 | Yes |
| 3142 | 2148 | 1074.0 | 45.61 | 22.8 | Plant pathogens and integrated defence responses to infection. | J L Dangl, J D Jones | Nature | 2001 | 11459065 | No |
| 3143 | 5369 | 1073.8 | 114.88 | 23.0 | The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. | J W Harper, G R Adami, N Wei, K Keyomarsi, S J Elledge | Cell | 1993 | 8242751 | Yes |
| 3144 | 2147 | 1073.5 | 104.64 | 52.3 | Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. | S F Dworkin, L LeResche | J Craniomandib Disord | 1992 | 1298767 | No |
| 3145 | 1073 | 1073.0 | 33.6 | 33.6 | MOPAC: a semiempirical molecular orbital program. | J J Stewart | J Comput Aided Mol Des | 1990 | 2197373 | No |
| 3146 | 1073 | 1073.0 | 23.49 | 23.5 | PHD: predicting one-dimensional protein structure by profile-based neural networks. | B Rost | Methods Enzymol | 1996 | 8743704 | Yes |
| 3147 | 1073 | 1073.0 | 27.42 | 27.4 | Automatic quantitation of localized in vivo 1H spectra with LCModel. | S W Provencher | NMR Biomed | 2001 | 11410943 | Yes |
| 3148 | 1073 | 1073.0 | 34.29 | 34.3 | MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. | Amy E Pasquinelli | Nat Rev Genet | 2012 | 22411466 | No |
| 3149 | 1072 | 1072.0 | 25.71 | 25.7 | Cells in stress: transcriptional activation of heat shock genes. | R I Morimoto | Science | 1993 | 8451637 | No |
| 3150 | 1072 | 1072.0 | 25.79 | 25.8 | Aptamers: an emerging class of molecules that rival antibodies in diagnostics. | S D Jayasena | Clin Chem | 1999 | 10471678 | No |
| 3151 | 1072 | 1072.0 | 20.52 | 20.5 | Biological robustness. | Hiroaki Kitano | Nat Rev Genet | 2004 | 15520792 | No |
| 3152 | 2143 | 1071.5 | 62.42 | 31.2 | The acute phase response. | H Baumann, J Gauldie | Immunol Today | 1994 | 7512342 | No |
| 3153 | 2143 | 1071.5 | 58.61 | 29.3 | Chlorophyll fluorescence--a practical guide. | K Maxwell, G N Johnson | J Exp Bot | 2000 | 10938857 | No |
| 3154 | 1071 | 1071.0 | 0.0 | 0.0 | The epidemiologic transition. A theory of the epidemiology of population change. | A R Omran | Milbank Mem Fund Q | 1971 | 5155251 | Yes |
| 3155 | 2142 | 1071.0 | 54.11 | 27.1 | The protective effects of estrogen on the cardiovascular system. | M E Mendelsohn, R H Karas | N Engl J Med | 1999 | 10362825 | No |
| 3156 | 1071 | 1071.0 | 0.0 | 0.0 | A production of amino acids under possible primitive earth conditions. | S L Miller | Science | 1953 | 13056598 | Yes |
| 3157 | 1071 | 1071.0 | 25.78 | 25.8 | The impact of next-generation sequencing technology on genetics. | Elaine R Mardis | Trends Genet | 2008 | 18262675 | No |
| 3158 | 2141 | 1070.5 | 48.48 | 24.2 | Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. | N Sreerama, R W Woody | Anal Biochem | 2000 | 11112271 | Yes |
| 3159 | 1070 | 1070.0 | 18.68 | 18.7 | Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. | R Rothstein | Methods Enzymol | 1991 | 2005793 | Yes |
| 3160 | 1070 | 1070.0 | 20.22 | 20.2 | Chronic myeloid leukemia. | C L Sawyers | N Engl J Med | 1999 | 10219069 | No |
| 3161 | 1070 | 1070.0 | 19.22 | 19.2 | Regulatory T cells in autoimmmunity*. | E M Shevach | Annu Rev Immunol | 2000 | 10837065 | No |
| 3162 | 1070 | 1070.0 | 19.51 | 19.5 | Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. | Eric C Lai | Nat Genet | 2002 | 11896390 | Yes |
| 3163 | 1070 | 1070.0 | 30.09 | 30.1 | Disseminating innovations in health care. | Donald M Berwick | JAMA | 2003 | 12697800 | Yes |
| 3164 | 1070 | 1070.0 | 24.48 | 24.5 | How neutrophils kill microbes. | Anthony W Segal | Annu Rev Immunol | 2005 | 15771570 | No |
| 3165 | 2140 | 1070.0 | 136.08 | 68.0 | Cancer immunotherapy using checkpoint blockade. | Antoni Ribas, Jedd D Wolchok | Science | 2018 | 29567705 | No |
| 3166 | 3209 | 1069.7 | 102.0 | 34.0 | Health benefits of physical activity: the evidence. | Darren E R Warburton, Crystal Whitney Nicol, Shannon S D Bredin | CMAJ | 2006 | 16534088 | No |
| 3167 | 1069 | 1069.0 | 24.82 | 24.8 | Current concepts of the pathogenesis of the acute coronary syndromes. | P Libby | Circulation | 2001 | 11457759 | No |
| 3168 | 6413 | 1068.8 | 162.91 | 27.2 | Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. | S Yusuf, P Sleight, J Pogue, J Bosch, R Davies, G Dagenais | N Engl J Med | 2000 | 10639539 | Yes |
| 3169 | 4275 | 1068.8 | 156.85 | 39.2 | Prevalence and trends in obesity among US adults, 1999-2008. | Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R Curtin | JAMA | 2010 | 20071471 | Yes |
| 3170 | 3206 | 1068.7 | 86.74 | 28.9 | Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. | R Schreck, P Rieber, P A Baeuerle | EMBO J | 1991 | 2065663 | Yes |
| 3171 | 3206 | 1068.7 | 89.3 | 29.8 | Methods in mammalian autophagy research. | Noboru Mizushima, Tamotsu Yoshimori, Beth Levine | Cell | 2010 | 20144757 | Yes |
| 3172 | 2137 | 1068.5 | 0.0 | 0.0 | Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. | R R Guillard, J H Ryther | Can J Microbiol | 1962 | 13902807 | Yes |
| 3173 | 7477 | 1068.1 | 225.98 | 32.3 | Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. | H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E Marsh | Stroke | 1993 | 7678184 | Yes |
| 3174 | 1068 | 1068.0 | 0.0 | 0.0 | Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. | P Stastny | N Engl J Med | 1978 | 147420 | Yes |
| 3175 | 1068 | 1068.0 | 0.0 | 0.0 | Statistical quality control and routine data processing for radioimmunoassays and immunoradiometric assays. | D Rodbard | Clin Chem | 1974 | 4370388 | No |
| 3176 | 2136 | 1068.0 | 50.86 | 25.4 | Hepatitis C virus infection. | G M Lauer, B D Walker | N Engl J Med | 2001 | 11439948 | No |
| 3177 | 1068 | 1068.0 | 21.49 | 21.5 | Regulation of cadherin-mediated adhesion in morphogenesis. | Barry M Gumbiner | Nat Rev Mol Cell Biol | 2005 | 16025097 | No |
| 3178 | 5339 | 1067.8 | 103.66 | 20.7 | The protein kinase complement of the human genome. | G Manning, D B Whyte, R Martinez, T Hunter, S Sudarsanam | Science | 2002 | 12471243 | No |
| 3179 | 1067 | 1067.0 | 0.0 | 0.0 | Functional connections between cells as revealed by dye-coupling with a highly fluorescent naphthalimide tracer. | W W Stewart | Cell | 1978 | 688392 | Yes |
| 3180 | 2134 | 1067.0 | 0.0 | 0.0 | Binding of soluble form of fibroblast surface protein, fibronectin, to collagen. | E Engvall, E Ruoslahti | Int J Cancer | 1977 | 903179 | Yes |
| 3181 | 1067 | 1067.0 | 23.76 | 23.8 | Molecular imaging of cancer with positron emission tomography. | Sanjiv Sam Gambhir | Nat Rev Cancer | 2002 | 12209157 | No |
| 3182 | 2134 | 1067.0 | 0.0 | 0.0 | Cortisone in ulcerative colitis; final report on a therapeutic trial. | S C Truelove, L J Witts | Br Med J | 1955 | 13260656 | Yes |
| 3183 | 1067 | 1067.0 | 23.13 | 23.1 | Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. | Sean B Carroll | Cell | 2008 | 18614008 | Yes |
| 3184 | 2133 | 1066.5 | 76.95 | 38.5 | Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. | A I Basbaum, H L Fields | Annu Rev Neurosci | 1984 | 6143527 | No |
| 3185 | 2133 | 1066.5 | 57.12 | 28.6 | Epidemiology of Parkinson's disease. | Lonneke M L de Lau, Monique M B Breteler | Lancet Neurol | 2006 | 16713924 | No |
| 3186 | 1066 | 1066.0 | 0.0 | 0.0 | Protein denaturation. C. Theoretical models for the mechanism of denaturation. | C Tanford | Adv Protein Chem | 1970 | 4912353 | No |
| 3187 | 2132 | 1066.0 | 0.0 | 0.0 | Calcium-dependent bacteriophage DNA infection. | M Mandel, A Higa | J Mol Biol | 1970 | 4922220 | Yes |
| 3188 | 1066 | 1066.0 | 47.71 | 47.7 | Coping theory and research: past, present, and future. | R S Lazarus | Psychosom Med | 1993 | 8346332 | No |
| 3189 | 1066 | 1066.0 | 25.18 | 25.2 | Selectins and their ligands: current concepts and controversies. | G S Kansas | Blood | 1996 | 8896391 | No |
| 3190 | 1066 | 1066.0 | 21.49 | 21.5 | Coiled coils: new structures and new functions. | A Lupas | Trends Biochem Sci | 1996 | 8918191 | No |
| 3191 | 2132 | 1066.0 | 45.26 | 22.6 | Mitogen-activated protein kinase pathways. | M J Robinson, M H Cobb | Curr Opin Cell Biol | 1997 | 9069255 | No |
| 3192 | 1066 | 1066.0 | 20.22 | 20.2 | The ubiquitin-proteasome pathway: on protein death and cell life. | A Ciechanover | EMBO J | 1998 | 9857172 | No |
| 3193 | 1066 | 1066.0 | 29.29 | 29.3 | The emotional dog and its rational tail: a social intuitionist approach to moral judgment. | J Haidt | Psychol Rev | 2001 | 11699120 | Yes |
| 3194 | 1066 | 1066.0 | 51.63 | 51.6 | Environmentally induced oxidative stress in aquatic animals. | Volodymyr I Lushchak | Aquat Toxicol | 2011 | 21074869 | No |
| 3195 | 2131 | 1065.5 | 45.74 | 22.9 | The Hsp70 and Hsp60 chaperone machines. | B Bukau, A L Horwich | Cell | 1998 | 9476895 | No |
| 3196 | 1065 | 1065.0 | 25.02 | 25.0 | Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. | S H Kaufmann | Cancer Res | 1989 | 2790800 | Yes |
| 3197 | 1065 | 1065.0 | 38.54 | 38.5 | Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. | M A Lemp | CLAO J | 1995 | 8565190 | No |
| 3198 | 3194 | 1064.7 | 0.0 | 0.0 | Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. | M Jondal, G Holm, H Wigzell | J Exp Med | 1972 | 4114496 | Yes |
| 3199 | 2129 | 1064.5 | 0.0 | 0.0 | The growth of mouse bone marrow cells in vitro. | T R Bradley, D Metcalf | Aust J Exp Biol Med Sci | 1966 | 4164182 | Yes |
| 3200 | 2128 | 1064.0 | 69.38 | 34.7 | Wine, alcohol, platelets, and the French paradox for coronary heart disease. | S Renaud, M de Lorgeril | Lancet | 1992 | 1351198 | Yes |
| 3201 | 1064 | 1064.0 | 32.1 | 32.1 | Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. | P S Tofts | J Magn Reson Imaging | 1997 | 9039598 | No |
| 3202 | 2128 | 1064.0 | 0.0 | 0.0 | Chronic catheterization of the spinal subarachnoid space. | T L Yaksh, T A Rudy | Physiol Behav | 1976 | 14677603 | Yes |
| 3203 | 1064 | 1064.0 | 26.68 | 26.7 | Context and behavioral processes in extinction. | Mark E Bouton | Learn Mem | 2004 | 15466298 | No |
| 3204 | 3192 | 1064.0 | 152.89 | 51.0 | The behaviour change wheel: a new method for characterising and designing behaviour change interventions. | Susan Michie, Maartje M van Stralen, Robert West | Implement Sci | 2011 | 21513547 | No |
| 3205 | 2126 | 1063.0 | 0.0 | 0.0 | The pathogenesis of atherosclerosis (first of two parts). | R Ross, J A Glomset | N Engl J Med | 1976 | 819830 | No |
| 3206 | 1063 | 1063.0 | 20.54 | 20.5 | At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. | M Kozak | J Mol Biol | 1987 | 3681984 | Yes |
| 3207 | 1063 | 1063.0 | 23.55 | 23.6 | Complement. Second of two parts. | M J Walport | N Engl J Med | 2001 | 11297706 | No |
| 3208 | 1063 | 1063.0 | 28.67 | 28.7 | TNF-mediated inflammatory disease. | J R Bradley | J Pathol | 2008 | 18161752 | No |
| 3209 | 2126 | 1063.0 | 72.83 | 36.4 | Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. | Christine Vogel, Edward M Marcotte | Nat Rev Genet | 2012 | 22411467 | No |
| 3210 | 2125 | 1062.5 | 48.63 | 24.3 | Synaptic activity and the construction of cortical circuits. | L C Katz, C J Shatz | Science | 1996 | 8895456 | No |
| 3211 | 4249 | 1062.2 | 115.93 | 29.0 | Universal sample preparation method for proteome analysis. | Jacek R Wiśniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias Mann | Nat Methods | 2009 | 19377485 | Yes |
| 3212 | 1062 | 1062.0 | 0.0 | 0.0 | Cell lines derived from late embryonic stages of Drosophila melanogaster. | I Schneider | J Embryol Exp Morphol | 1972 | 4625067 | Yes |
| 3213 | 1062 | 1062.0 | 30.38 | 30.4 | Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine. | E M Tan | Adv Immunol | 1982 | 6182766 | No |
| 3214 | 1062 | 1062.0 | 24.29 | 24.3 | Toward self-organization and complex matter. | Jean-Marie Lehn | Science | 2002 | 11923524 | Yes |
| 3215 | 1061 | 1061.0 | 34.24 | 34.2 | Peritonectomy procedures. | P H Sugarbaker | Ann Surg | 1995 | 7826158 | Yes |
| 3216 | 1061 | 1061.0 | 23.61 | 23.6 | ECM and cell surface proteolysis: regulating cellular ecology. | Z Werb | Cell | 1997 | 9390552 | No |
| 3217 | 1061 | 1061.0 | 24.62 | 24.6 | Hypoxia, HIF1 and glucose metabolism in the solid tumour. | Nicholas C Denko | Nat Rev Cancer | 2008 | 19143055 | No |
| 3218 | 1061 | 1061.0 | 40.55 | 40.5 | Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. | Rui Wang | Physiol Rev | 2012 | 22535897 | No |
| 3219 | 2121 | 1060.5 | 0.0 | 0.0 | Histochemistry of hepatic phosphatases of a physiologic pH; with special reference to the demonstration of bile canaliculi. | M Wachstein, E Meisel | Am J Clin Pathol | 1957 | 13410831 | Yes |
| 3220 | 1060 | 1060.0 | 0.0 | 0.0 | Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. | D L Coleman | Diabetologia | 1978 | 350680 | No |
| 3221 | 1060 | 1060.0 | 31.09 | 31.1 | Stronger Brønsted acids. | Takahiko Akiyama | Chem Rev | 2007 | 17983247 | Yes |
| 3222 | 1060 | 1060.0 | 29.28 | 29.3 | Molecular genetics of colorectal cancer. | Eric R Fearon | Annu Rev Pathol | 2011 | 21090969 | No |
| 3223 | 2120 | 1060.0 | 69.93 | 35.0 | Inflammatory mechanisms in obesity. | Margaret F Gregor, Gökhan S Hotamisligil | Annu Rev Immunol | 2011 | 21219177 | No |
| 3224 | 8476 | 1059.5 | 238.57 | 29.8 | A method and server for predicting damaging missense mutations. | Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R Sunyaev | Nat Methods | 2010 | 20354512 | Yes |
| 3225 | 3178 | 1059.3 | 162.97 | 54.3 | Assessing coping strategies: a theoretically based approach. | C S Carver, M F Scheier, J K Weintraub | J Pers Soc Psychol | 1989 | 2926629 | Yes |
| 3226 | 4237 | 1059.2 | 147.1 | 36.8 | Common method biases in behavioral research: a critical review of the literature and recommended remedies. | Philip M Podsakoff, Scott B MacKenzie, Jeong-Yeon Lee, Nathan P Podsakoff | J Appl Psychol | 2003 | 14516251 | No |
| 3227 | 1059 | 1059.0 | 0.0 | 0.0 | A colorimetric method for estimating serum triglycerides. | M J Fletcher | Clin Chim Acta | 1968 | 5696963 | Yes |
| 3228 | 1059 | 1059.0 | 0.0 | 0.0 | Mechanisms of lipid peroxide formation in animal tissues. | E D Wills | Biochem J | 1966 | 5964963 | Yes |
| 3229 | 1059 | 1059.0 | 22.13 | 22.1 | mRNA stability in mammalian cells. | J Ross | Microbiol Rev | 1995 | 7565413 | No |
| 3230 | 1059 | 1059.0 | 26.76 | 26.8 | Mode of action of membrane active antimicrobial peptides. | Yechiel Shai | Biopolymers | 2002 | 12491537 | No |
| 3231 | 1059 | 1059.0 | 0.0 | 0.0 | Notes on continuous stochastic phenomena. | P A P Moran | Biometrika | 1950 | 15420245 | Yes |
| 3232 | 1058 | 1058.0 | 27.37 | 27.4 | Two-stage model of memory trace formation: a role for "noisy" brain states. | G Buzsáki | Neuroscience | 1989 | 2687720 | No |
| 3233 | 1058 | 1058.0 | 0.0 | 0.0 | The ultrastructural basis of capillary permeability studied with peroxidase as a tracer. | M J Karnovsky | J Cell Biol | 1967 | 6061717 | Yes |
| 3234 | 1058 | 1058.0 | 38.66 | 38.7 | Coronary physiology. | E O Feigl | Physiol Rev | 1983 | 6296890 | No |
| 3235 | 3174 | 1058.0 | 149.95 | 50.0 | Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. | F Guillemin, C Bombardier, D Beaton | J Clin Epidemiol | 1993 | 8263569 | No |
| 3236 | 1058 | 1058.0 | 27.79 | 27.8 | Neuropathology of Parkinson's disease. | L S Forno | J Neuropathol Exp Neurol | 1996 | 8786384 | No |
| 3237 | 1058 | 1058.0 | 36.0 | 36.0 | Socioeconomic disadvantage and child development. | V C McLoyd | Am Psychol | 1998 | 9491747 | No |
| 3238 | 1058 | 1058.0 | 24.32 | 24.3 | Measuring information transfer | Schreiber | Phys Rev Lett | 2000 | 10991308 | Yes |
| 3239 | 1057 | 1057.0 | 21.94 | 21.9 | The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells. | D Metcalf | Nature | 1989 | 2469962 | No |
| 3240 | 1057 | 1057.0 | 25.96 | 26.0 | The granulocyte-macrophage colony-stimulating factors. | D Metcalf | Science | 1985 | 2990035 | No |
| 3241 | 1057 | 1057.0 | 0.0 | 0.0 | Microtubule formation in vitro in solutions containing low calcium concentrations. | R C Weisenberg | Science | 1972 | 4626639 | Yes |
| 3242 | 1057 | 1057.0 | 20.7 | 20.7 | Focal adhesion kinase: the first ten years. | J Thomas Parsons | J Cell Sci | 2003 | 12640026 | No |
| 3243 | 2113 | 1056.5 | 0.0 | 0.0 | Use of glucose oxidase, peroxidase, and O-dianisidine in determination of blood and urinary glucose. | A S Huggett, D A Nixon | Lancet | 1957 | 13464070 | Yes |
| 3244 | 2113 | 1056.5 | 49.25 | 24.6 | Blinded by the Light: The Growing Complexity of p53. | Karen H Vousden, Carol Prives | Cell | 2009 | 19410540 | No |
| 3245 | 1056 | 1056.0 | 31.06 | 31.1 | Animal mitochondrial DNA: structure and evolution. | D R Wolstenholme | Int Rev Cytol | 1992 | 1452431 | No |
| 3246 | 1056 | 1056.0 | 29.88 | 29.9 | Mitochondrial genetics: a paradigm for aging and degenerative diseases? | D C Wallace | Science | 1992 | 1533953 | Yes |
| 3247 | 1056 | 1056.0 | 56.3 | 56.3 | A "rationalized" arcsine transform. | G A Studebaker | J Speech Hear Res | 1985 | 4046587 | Yes |
| 3248 | 1056 | 1056.0 | 0.0 | 0.0 | The Permeability Of Capillaries In Various Organs As Determined By Use Of The 'Indicator Diffusion' Method. | C Crone | Acta Physiol Scand | 1963 | 14078649 | Yes |
| 3249 | 1056 | 1056.0 | 31.94 | 31.9 | Regulation of glutathione synthesis. | Shelly C Lu | Mol Aspects Med | 2009 | 18601945 | No |
| 3250 | 1055 | 1055.0 | 30.38 | 30.4 | Junctional intercellular communication: the cell-to-cell membrane channel. | W R Loewenstein | Physiol Rev | 1981 | 6270711 | No |
| 3251 | 1055 | 1055.0 | 32.59 | 32.6 | Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. | P J Basser | NMR Biomed | 1995 | 8739270 | No |
| 3252 | 2110 | 1055.0 | 50.49 | 25.2 | A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. | J N Cohn, G Tognoni | N Engl J Med | 2001 | 11759645 | Yes |
| 3253 | 1055 | 1055.0 | 30.35 | 30.4 | A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. | Ron Hardman | Environ Health Perspect | 2006 | 16451849 | No |
| 3254 | 1054 | 1054.0 | 23.01 | 23.0 | Microsatellites: simple sequences with complex evolution. | Hans Ellegren | Nat Rev Genet | 2004 | 15153996 | No |
| 3255 | 2108 | 1054.0 | 51.1 | 25.6 | Next-generation DNA sequencing. | Jay Shendure, Hanlee Ji | Nat Biotechnol | 2008 | 18846087 | Yes |
| 3256 | 4215 | 1053.8 | 217.35 | 54.3 | National Institute of Mental Health Diagnostic Interview Schedule. Its history, characteristics, and validity. | L N Robins, J E Helzer, J Croughan, K S Ratcliff | Arch Gen Psychiatry | 1981 | 6260053 | Yes |
| 3257 | 6322 | 1053.7 | 182.25 | 30.4 | Cancer statistics, 2007. | Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Taylor Murray, Jiaquan Xu, Michael J Thun | CA Cancer J Clin | 2007 | 17237035 | Yes |
| 3258 | 2107 | 1053.5 | 0.0 | 0.0 | A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. | J J Sedmak, S E Grossberg | Anal Biochem | 1977 | 68686 | Yes |
| 3259 | 2107 | 1053.5 | 43.13 | 21.6 | Tumour-cell invasion and migration: diversity and escape mechanisms. | Peter Friedl, Katarina Wolf | Nat Rev Cancer | 2003 | 12724734 | No |
| 3260 | 1053 | 1053.0 | 27.07 | 27.1 | Axonal growth-associated proteins. | J H Skene | Annu Rev Neurosci | 1989 | 2648946 | No |
| 3261 | 1053 | 1053.0 | 29.17 | 29.2 | T-cell growth factor. | K A Smith | Immunol Rev | 1980 | 7000676 | No |
| 3262 | 1053 | 1053.0 | 26.33 | 26.3 | Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults. | Bei-Fan Zhou | Biomed Environ Sci | 2002 | 12046553 | Yes |
| 3263 | 1052 | 1052.0 | 27.29 | 27.3 | Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. | J P Tam | Proc Natl Acad Sci U S A | 1988 | 3399498 | Yes |
| 3264 | 1052 | 1052.0 | 29.71 | 29.7 | Determination of total protein. | G L Peterson | Methods Enzymol | 1983 | 6855607 | Yes |
| 3265 | 1052 | 1052.0 | 30.61 | 30.6 | Pathogenetic mechanisms of septic shock. | J E Parrillo | N Engl J Med | 1993 | 8479467 | No |
| 3266 | 1052 | 1052.0 | 24.42 | 24.4 | Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis. | Tirion | Phys Rev Lett | 1996 | 10063201 | Yes |
| 3267 | 2104 | 1052.0 | 43.7 | 21.9 | Community structure in social and biological networks. | M Girvan, M E J Newman | Proc Natl Acad Sci U S A | 2002 | 12060727 | No |
| 3268 | 2104 | 1052.0 | 92.3 | 46.1 | Liposomal drug delivery systems: from concept to clinical applications. | Theresa M Allen, Pieter R Cullis | Adv Drug Deliv Rev | 2013 | 23036225 | No |
| 3269 | 1052 | 1052.0 | 49.17 | 49.2 | Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. | Konrad M Andrassy | Kidney Int | 2013 | 23989362 | Yes |
| 3270 | 2103 | 1051.5 | 63.5 | 31.8 | The biochemistry of P-glycoprotein-mediated multidrug resistance. | J A Endicott, V Ling | Annu Rev Biochem | 1989 | 2570548 | No |
| 3271 | 1051 | 1051.0 | 56.75 | 56.8 | The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. | G A Ilizarov | Clin Orthop Relat Res | 1989 | 2910611 | Yes |
| 3272 | 1051 | 1051.0 | 0.0 | 0.0 | Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. | S Irwin | Psychopharmacologia | 1968 | 5679627 | Yes |
| 3273 | 1051 | 1051.0 | 0.0 | 0.0 | The effect of emotion on cue utilization and the organization of behavior. | J A Easterbrook | Psychol Rev | 1959 | 13658305 | Yes |
| 3274 | 1051 | 1051.0 | 21.61 | 21.6 | Telomeres and human disease: ageing, cancer and beyond. | Maria A Blasco | Nat Rev Genet | 2005 | 16136653 | No |
| 3275 | 2102 | 1051.0 | 51.79 | 25.9 | Modes of resistance to anti-angiogenic therapy. | Gabriele Bergers, Douglas Hanahan | Nat Rev Cancer | 2008 | 18650835 | No |
| 3276 | 1050 | 1050.0 | 40.32 | 40.3 | Infection by verocytotoxin-producing Escherichia coli. | M A Karmali | Clin Microbiol Rev | 1989 | 2644022 | No |
| 3277 | 1050 | 1050.0 | 0.0 | 0.0 | Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent. | D L Morris | Science | 1948 | 17814729 | Yes |
| 3278 | 1050 | 1050.0 | 22.82 | 22.8 | Up on the tightrope: natural killer cell activation and inhibition. | Lewis L Lanier | Nat Immunol | 2008 | 18425106 | No |
| 3279 | 2099 | 1049.5 | 0.0 | 0.0 | A microcolorimetric method for the determination of inorganic phosphorus. | H H Taussky, E Shorr | J Biol Chem | 1953 | 13061491 | Yes |
| 3280 | 4196 | 1049.0 | 0.0 | 0.0 | T cell growth factor: parameters of production and a quantitative microassay for activity. | S Gillis, M M Ferm, W Ou, K A Smith | J Immunol | 1978 | 307029 | Yes |
| 3281 | 1049 | 1049.0 | 0.0 | 0.0 | The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture. | J Cassel | Am J Epidemiol | 1976 | 782233 | No |
| 3282 | 1049 | 1049.0 | 30.0 | 30.0 | Transport of molecules in the tumor interstitium: a review. | R K Jain | Cancer Res | 1987 | 3555767 | No |
| 3283 | 1049 | 1049.0 | 0.0 | 0.0 | Cell communication, calcium ion, and cyclic adenosine monophosphate. | H Rasmussen | Science | 1970 | 4318972 | Yes |
| 3284 | 1049 | 1049.0 | 36.58 | 36.6 | A review of psychological risk factors in back and neck pain. | S J Linton | Spine (Phila Pa 1976) | 2000 | 10788861 | No |
| 3285 | 1049 | 1049.0 | 25.21 | 25.2 | A likelihood approach to estimating phylogeny from discrete morphological character data. | P O Lewis | Syst Biol | 2001 | 12116640 | Yes |
| 3286 | 3146 | 1048.7 | 113.59 | 37.9 | Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. | P S Walsh, D A Metzger, R Higuchi | Biotechniques | 1991 | 1867860 | Yes |
| 3287 | 2097 | 1048.5 | 82.57 | 41.3 | Cronbach's alpha. | J M Bland, D G Altman | BMJ | 1997 | 9055718 | Yes |
| 3288 | 5242 | 1048.4 | 163.21 | 32.6 | Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. | Salim Yusuf, Bertram Pitt, Clarence E Davis, William B Hood, Jay N Cohn | N Engl J Med | 1991 | 2057034 | Yes |
| 3289 | 1048 | 1048.0 | 23.9 | 23.9 | The inducible transcription activator NF-kappa B: regulation by distinct protein subunits. | P A Baeuerle | Biochim Biophys Acta | 1991 | 2018779 | No |
| 3290 | 1048 | 1048.0 | 0.0 | 0.0 | Epidemiology of cancer of the colon and rectum. | D P Burkitt | Cancer | 1971 | 5165022 | Yes |
| 3291 | 1048 | 1048.0 | 35.54 | 35.5 | High density lipoprotein metabolism. | S Eisenberg | J Lipid Res | 1984 | 6392459 | No |
| 3292 | 1048 | 1048.0 | 23.65 | 23.6 | Pedigree disequilibrium tests for multilocus haplotypes. | Frank Dudbridge | Genet Epidemiol | 2003 | 12916020 | Yes |
| 3293 | 5236 | 1047.2 | 107.57 | 21.5 | Electrostatics of nanosystems: application to microtubules and the ribosome. | N A Baker, D Sept, S Joseph, M J Holst, J A McCammon | Proc Natl Acad Sci U S A | 2001 | 11517324 | Yes |
| 3294 | 2094 | 1047.0 | 40.99 | 20.5 | Improved retroviral vectors for gene transfer and expression. | A D Miller, G J Rosman | Biotechniques | 1989 | 2631796 | Yes |
| 3295 | 1047 | 1047.0 | 26.09 | 26.1 | The sphingomyelin cycle and the second messenger function of ceramide. | Y A Hannun | J Biol Chem | 1994 | 8106344 | No |
| 3296 | 1047 | 1047.0 | 29.09 | 29.1 | Akaike's information criterion in generalized estimating equations. | W Pan | Biometrics | 2001 | 11252586 | Yes |
| 3297 | 1047 | 1047.0 | 20.34 | 20.3 | Progress in human tumour immunology and immunotherapy. | S A Rosenberg | Nature | 2001 | 11357146 | No |
| 3298 | 1047 | 1047.0 | 28.76 | 28.8 | Epidemiology of women and depression. | Ronald C Kessler | J Affect Disord | 2003 | 12646294 | Yes |
| 3299 | 1047 | 1047.0 | 60.26 | 60.3 | PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors. | Anthony L Spek | Acta Crystallogr C Struct Chem | 2015 | 25567569 | Yes |
| 3300 | 4187 | 1046.8 | 169.52 | 42.4 | FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. | Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs Schoffelen | Comput Intell Neurosci | 2011 | 21253357 | Yes |
| 3301 | 3139 | 1046.3 | 63.01 | 21.0 | Exosomes: composition, biogenesis and function. | Clotilde Théry, Laurence Zitvogel, Sebastian Amigorena | Nat Rev Immunol | 2002 | 12154376 | No |
| 3302 | 2092 | 1046.0 | 41.95 | 21.0 | A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. | C S Hoffman, F Winston | Gene | 1987 | 3319781 | Yes |
| 3303 | 2092 | 1046.0 | 54.04 | 27.0 | Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. | M S Brown, J L Goldstein | Annu Rev Biochem | 1983 | 6311077 | No |
| 3304 | 1046 | 1046.0 | 21.36 | 21.4 | ChIP-seq: advantages and challenges of a maturing technology. | Peter J Park | Nat Rev Genet | 2009 | 19736561 | No |
| 3305 | 1046 | 1046.0 | 0.0 | 0.0 | A Serological Differentiation Of Human And Other Groups Of Hemolytic Streptococci. | R C Lancefield | J Exp Med | 1933 | 19870148 | Yes |
| 3306 | 2091 | 1045.5 | 77.62 | 38.8 | Fingerprinting genomes using PCR with arbitrary primers. | J Welsh, M McClelland | Nucleic Acids Res | 1990 | 2259619 | Yes |
| 3307 | 2090 | 1045.0 | 62.26 | 31.1 | Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. | J M Reul, E R de Kloet | Endocrinology | 1985 | 2998738 | Yes |
| 3308 | 1045 | 1045.0 | 24.3 | 24.3 | The columnar organization of the neocortex. | V B Mountcastle | Brain | 1997 | 9153131 | No |
| 3309 | 1045 | 1045.0 | 19.39 | 19.4 | The Pezcoller lecture: cancer cell cycles revisited. | C J Sherr | Cancer Res | 2000 | 10919634 | No |
| 3310 | 1045 | 1045.0 | 22.32 | 22.3 | Fibrotic disease and the T(H)1/T(H)2 paradigm. | Thomas A Wynn | Nat Rev Immunol | 2004 | 15286725 | No |
| 3311 | 7315 | 1045.0 | 220.64 | 31.5 | BLAST+: architecture and applications. | Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L Madden | BMC Bioinformatics | 2009 | 20003500 | Yes |
| 3312 | 2089 | 1044.5 | 55.51 | 27.8 | Humans integrate visual and haptic information in a statistically optimal fashion. | Marc O Ernst, Martin S Banks | Nature | 2002 | 11807554 | Yes |
| 3313 | 1044 | 1044.0 | 0.0 | 0.0 | Avidin. | N M Green | Adv Protein Chem | 1975 | 237414 | Yes |
| 3314 | 1044 | 1044.0 | 34.56 | 34.6 | Agents that increase the permeability of the outer membrane. | M Vaara | Microbiol Rev | 1992 | 1406489 | No |
| 3315 | 2088 | 1044.0 | 44.93 | 22.5 | The immunoglobulin superfamily--domains for cell surface recognition. | A F Williams, A N Barclay | Annu Rev Immunol | 1988 | 3289571 | No |
| 3316 | 1044 | 1044.0 | 50.98 | 51.0 | Analysis of Fickian and non-Fickian drug release from polymers. | N A Peppas | Pharm Acta Helv | 1985 | 4011621 | Yes |
| 3317 | 4176 | 1044.0 | 109.34 | 27.3 | Real time quantitative PCR. | C A Heid, J Stevens, K J Livak, P M Williams | Genome Res | 1996 | 8908518 | Yes |
| 3318 | 1044 | 1044.0 | 23.17 | 23.2 | Epstein-Barr virus infection. | J I Cohen | N Engl J Med | 2000 | 10944566 | No |
| 3319 | 2087 | 1043.5 | 47.67 | 23.8 | Obesity and insulin resistance. | B B Kahn, J S Flier | J Clin Invest | 2000 | 10953022 | No |
| 3320 | 1043 | 1043.0 | 25.58 | 25.6 | Quantification of beta-sheet amyloid fibril structures with thioflavin T. | H LeVine | Methods Enzymol | 1999 | 10507030 | Yes |
| 3321 | 2086 | 1043.0 | 55.26 | 27.6 | An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. | Gary Aston-Jones, Jonathan D Cohen | Annu Rev Neurosci | 2005 | 16022602 | No |
| 3322 | 2086 | 1043.0 | 65.75 | 32.9 | Health effects of fine particulate air pollution: lines that connect. | C Arden Pope, Douglas W Dockery | J Air Waste Manag Assoc | 2006 | 16805397 | No |
| 3323 | 1043 | 1043.0 | 23.14 | 23.1 | Membrane recognition by phospholipid-binding domains. | Mark A Lemmon | Nat Rev Mol Cell Biol | 2008 | 18216767 | No |
| 3324 | 2085 | 1042.5 | 41.23 | 20.6 | The druggable genome. | Andrew L Hopkins, Colin R Groom | Nat Rev Drug Discov | 2002 | 12209152 | No |
| 3325 | 6254 | 1042.3 | 168.79 | 28.1 | Prediction of coronary heart disease using risk factor categories. | P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B Kannel | Circulation | 1998 | 9603539 | Yes |
| 3326 | 1042 | 1042.0 | 0.0 | 0.0 | Carcinoid tumors. An analysis of 2,837 cases. | J D Godwin | Cancer | 1975 | 1157019 | Yes |
| 3327 | 1042 | 1042.0 | 24.18 | 24.2 | Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system. | T Ikemura | J Mol Biol | 1981 | 6175758 | Yes |
| 3328 | 1042 | 1042.0 | 41.42 | 41.4 | Amyloid deposits and amyloidosis: the beta-fibrilloses (second of two parts). | G G Glenner | N Engl J Med | 1980 | 6990257 | No |
| 3329 | 1042 | 1042.0 | 30.43 | 30.4 | Muscarinic receptors--characterization, coupling and function. | M P Caulfield | Pharmacol Ther | 1993 | 7504306 | No |
| 3330 | 2083 | 1041.5 | 51.33 | 25.7 | Efficient isolation of genes by using antibody probes. | R A Young, R W Davis | Proc Natl Acad Sci U S A | 1983 | 6219389 | Yes |
| 3331 | 2083 | 1041.5 | 62.13 | 31.1 | The capacity of visual working memory for features and conjunctions. | S J Luck, E K Vogel | Nature | 1997 | 9384378 | Yes |
| 3332 | 1041 | 1041.0 | 0.0 | 0.0 | Retention of differentiation potentialities during prolonged cultivation of myogenic cells. | D Yaffe | Proc Natl Acad Sci U S A | 1968 | 5245982 | Yes |
| 3333 | 1041 | 1041.0 | 33.48 | 33.5 | Sensorimotor integration in human postural control. | R J Peterka | J Neurophysiol | 2002 | 12205132 | Yes |
| 3334 | 4161 | 1040.2 | 155.66 | 38.9 | Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. | K F Schulz, I Chalmers, R J Hayes, D G Altman | JAMA | 1995 | 7823387 | Yes |
| 3335 | 2080 | 1040.0 | 49.2 | 24.6 | Cellular uptake of the tat protein from human immunodeficiency virus. | A D Frankel, C O Pabo | Cell | 1988 | 2849510 | Yes |
| 3336 | 1040 | 1040.0 | 0.0 | 0.0 | Lipid peroxidation damage to cell components. | A L Tappel | Fed Proc | 1973 | 4352451 | Yes |
| 3337 | 2080 | 1040.0 | 54.02 | 27.0 | Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis. | D C Schwartz, C R Cantor | Cell | 1984 | 6373014 | Yes |
| 3338 | 1040 | 1040.0 | 23.5 | 23.5 | Molecular mechanisms of myocardial remodeling. | B Swynghedauw | Physiol Rev | 1999 | 9922372 | No |
| 3339 | 1040 | 1040.0 | 0.0 | 0.0 | The stereotaxic method and radiosurgery of the brain. | L Leksell | Acta Chir Scand | 1951 | 14914373 | Yes |
| 3340 | 1039 | 1039.0 | 34.99 | 35.0 | Fever: role of pyrogens and cryogens. | M J Kluger | Physiol Rev | 1991 | 1986393 | No |
| 3341 | 1039 | 1039.0 | 28.22 | 28.2 | Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. | F P Guengerich | Chem Res Toxicol | 2001 | 11409933 | No |
| 3342 | 1039 | 1039.0 | 25.06 | 25.1 | P-450 metabolites of arachidonic acid in the control of cardiovascular function. | Richard J Roman | Physiol Rev | 2002 | 11773611 | No |
| 3343 | 1039 | 1039.0 | 29.83 | 29.8 | Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. | John W Newcomer | CNS Drugs | 2005 | 15998156 | No |
| 3344 | 2077 | 1038.5 | 43.86 | 21.9 | Genomic control for association studies. | B Devlin, K Roeder | Biometrics | 1999 | 11315092 | Yes |
| 3345 | 2077 | 1038.5 | 49.74 | 24.9 | Regulation of wound healing by growth factors and cytokines. | Sabine Werner, Richard Grose | Physiol Rev | 2003 | 12843410 | No |
| 3346 | 2076 | 1038.0 | 78.77 | 39.4 | A psychomotor stimulant theory of addiction. | R A Wise, M A Bozarth | Psychol Rev | 1987 | 3317472 | No |
| 3347 | 2076 | 1038.0 | 0.0 | 0.0 | A simple method for the preparation of 32-P-labelled adenosine triphosphate of high specific activity. | I M Glynn, J B Chappell | Biochem J | 1964 | 5832284 | Yes |
| 3348 | 1038 | 1038.0 | 43.47 | 43.5 | Toward terminological, conceptual, and statistical clarity in the study of mediators and moderators: examples from the child-clinical and pediatric psychology literatures. | G N Holmbeck | J Consult Clin Psychol | 1997 | 9256561 | Yes |
| 3349 | 1038 | 1038.0 | 29.78 | 29.8 | Riddle of biofilm resistance. | K Lewis | Antimicrob Agents Chemother | 2001 | 11257008 | No |
| 3350 | 3114 | 1038.0 | 94.61 | 31.5 | Validation of the Insomnia Severity Index as an outcome measure for insomnia research. | C H. Bastien, A Vallières, C M. Morin | Sleep Med | 2001 | 11438246 | Yes |
| 3351 | 1038 | 1038.0 | 21.88 | 21.9 | Osmotic stress signaling and osmoadaptation in yeasts. | Stefan Hohmann | Microbiol Mol Biol Rev | 2002 | 12040128 | No |
| 3352 | 1038 | 1038.0 | 19.93 | 19.9 | DNA methylation in cancer: too much, but also too little. | Melanie Ehrlich | Oncogene | 2002 | 12154403 | No |
| 3353 | 1038 | 1038.0 | 18.29 | 18.3 | Molecular mechanisms of axon guidance. | Barry J Dickson | Science | 2002 | 12471249 | No |
| 3354 | 3114 | 1038.0 | 101.3 | 33.8 | SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building. | Manolo Gouy, Stéphane Guindon, Olivier Gascuel | Mol Biol Evol | 2010 | 19854763 | Yes |
| 3355 | 2075 | 1037.5 | 36.89 | 18.4 | Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. | W Gu, R G Roeder | Cell | 1997 | 9288740 | Yes |
| 3356 | 2075 | 1037.5 | 39.88 | 19.9 | Wnt signaling: a common theme in animal development. | K M Cadigan, R Nusse | Genes Dev | 1997 | 9407023 | No |
| 3357 | 1037 | 1037.0 | 0.0 | 0.0 | Transformation of yeast by a replicating hybrid plasmid. | J D Beggs | Nature | 1978 | 357984 | Yes |
| 3358 | 1037 | 1037.0 | 27.86 | 27.9 | Human TH1 and TH2 subsets: doubt no more. | S Romagnani | Immunol Today | 1991 | 1680337 | Yes |
| 3359 | 1037 | 1037.0 | 22.07 | 22.1 | Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. | Z Yang | Mol Biol Evol | 1998 | 9580986 | Yes |
| 3360 | 1037 | 1037.0 | 0.0 | 0.0 | Cell deaths in normal vertebrate ontogeny. | A Glucksmann | Biol Rev Camb Philos Soc | 1951 | 24540363 | Yes |
| 3361 | 1036 | 1036.0 | 54.44 | 54.4 | The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. | G A Ilizarov | Clin Orthop Relat Res | 1989 | 2912628 | Yes |
| 3362 | 1036 | 1036.0 | 49.8 | 49.8 | Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder. | M Rutter | Br J Psychiatry | 1985 | 3830321 | Yes |
| 3363 | 4143 | 1035.8 | 106.07 | 26.5 | Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. | Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod Menon | Proc Natl Acad Sci U S A | 2003 | 12506194 | Yes |
| 3364 | 1035 | 1035.0 | 0.0 | 0.0 | Surface modulation in cell recognition and cell growth. | G M Edelman | Science | 1976 | 769162 | No |
| 3365 | 1035 | 1035.0 | 0.0 | 0.0 | Tests for emotionality in rats and mice: a review. | J Archer | Anim Behav | 1973 | 4578750 | No |
| 3366 | 1035 | 1035.0 | 29.88 | 29.9 | Limbic-cortical dysregulation: a proposed model of depression. | H S Mayberg | J Neuropsychiatry Clin Neurosci | 1997 | 9276848 | No |
| 3367 | 1035 | 1035.0 | 19.01 | 19.0 | Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. | W Kolch | Biochem J | 2000 | 11023813 | No |
| 3368 | 3103 | 1034.3 | 0.0 | 0.0 | Depression: a new animal model sensitive to antidepressant treatments. | R D Porsolt, M Le Pichon, M Jalfre | Nature | 1977 | 559941 | Yes |
| 3369 | 1034 | 1034.0 | 53.53 | 53.5 | The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. | J A Koufman | Laryngoscope | 1991 | 1895864 | No |
| 3370 | 3102 | 1034.0 | 85.6 | 28.5 | A nonparametric method for automatic correction of intensity nonuniformity in MRI data. | J G Sled, A P Zijdenbos, A C Evans | IEEE Trans Med Imaging | 1998 | 9617910 | Yes |
| 3371 | 2067 | 1033.5 | 0.0 | 0.0 | A modified ninhydrin reagent for the photometric determination of amino acids and related compounds. | S Moore, W H Stein | J Biol Chem | 1954 | 13221596 | Yes |
| 3372 | 4133 | 1033.2 | 84.77 | 21.2 | Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. | E Schreiber, P Matthias, M M Müller, W Schaffner | Nucleic Acids Res | 1989 | 2771659 | Yes |
| 3373 | 2066 | 1033.0 | 53.26 | 26.6 | The regulation and function of c-fos and other immediate early genes in the nervous system. | M Sheng, M E Greenberg | Neuron | 1990 | 1969743 | No |
| 3374 | 1033 | 1033.0 | 23.64 | 23.6 | Diffraction methods for biological macromolecules. Interactive computer graphics: FRODO. | T A Jones | Methods Enzymol | 1985 | 3841179 | Yes |
| 3375 | 1033 | 1033.0 | 0.0 | 0.0 | The interaction of a naphthalene dye with apomyoglobin and apohemoglobin. A fluorescent probe of non-polar binding sites. | L Stryer | J Mol Biol | 1965 | 5867031 | Yes |
| 3376 | 1033 | 1033.0 | 29.58 | 29.6 | The stress response to trauma and surgery. | J P Desborough | Br J Anaesth | 2000 | 10927999 | No |
| 3377 | 1033 | 1033.0 | 0.0 | 0.0 | Motivation reconsidered: the concept of competence. | R W White | Psychol Rev | 1959 | 13844397 | Yes |
| 3378 | 2066 | 1033.0 | 51.51 | 25.8 | ZINC--a free database of commercially available compounds for virtual screening. | John J Irwin, Brian K Shoichet | J Chem Inf Model | 2005 | 15667143 | Yes |
| 3379 | 1033 | 1033.0 | 22.83 | 22.8 | Phenotypic plasticity and the epigenetics of human disease. | Andrew P Feinberg | Nature | 2007 | 17522677 | No |
| 3380 | 3099 | 1033.0 | 0.0 | 0.0 | Therapeutic criteria in rheumatoid arthritis. | O Steinbrocker, C H Traeger, R C Batterman | J Am Med Assoc | 1949 | 18150288 | Yes |
| 3381 | 1033 | 1033.0 | 25.73 | 25.7 | Solid-state nanopores. | Cees Dekker | Nat Nanotechnol | 2007 | 18654264 | No |
| 3382 | 3098 | 1032.7 | 81.47 | 27.2 | Use and abuse of HOMA modeling. | Tara M Wallace, Jonathan C Levy, David R Matthews | Diabetes Care | 2004 | 15161807 | No |
| 3383 | 2065 | 1032.5 | 78.93 | 39.5 | Visual search and stimulus similarity. | J Duncan, G W Humphreys | Psychol Rev | 1989 | 2756067 | Yes |
| 3384 | 4129 | 1032.2 | 122.82 | 30.7 | Measurement of the elastic properties and intrinsic strength of monolayer graphene. | Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James Hone | Science | 2008 | 18635798 | Yes |
| 3385 | 2064 | 1032.0 | 46.41 | 23.2 | Protein-tyrosine kinases. | T Hunter, J A Cooper | Annu Rev Biochem | 1985 | 2992362 | No |
| 3386 | 1032 | 1032.0 | 28.91 | 28.9 | Synchronization of cortical activity and its putative role in information processing and learning. | W Singer | Annu Rev Physiol | 1993 | 8466179 | No |
| 3387 | 1032 | 1032.0 | 23.46 | 23.5 | New ideas about atrial fibrillation 50 years on. | Stanley Nattel | Nature | 2002 | 11805846 | No |
| 3388 | 2064 | 1032.0 | 44.38 | 22.2 | 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? | George Davey Smith, Shah Ebrahim | Int J Epidemiol | 2003 | 12689998 | No |
| 3389 | 2064 | 1032.0 | 56.16 | 28.1 | Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. | Felix Krueger, Simon R Andrews | Bioinformatics | 2011 | 21493656 | Yes |
| 3390 | 3094 | 1031.3 | 106.61 | 35.5 | The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting. | C Kirschbaum, K M Pirke, D H Hellhammer | Neuropsychobiology | 1993 | 8255414 | Yes |
| 3391 | 2062 | 1031.0 | 42.38 | 21.2 | IAP family proteins--suppressors of apoptosis. | Q L Deveraux, J C Reed | Genes Dev | 1999 | 9990849 | No |
| 3392 | 2062 | 1031.0 | 46.97 | 23.5 | Regeneration beyond the glial scar. | Jerry Silver, Jared H Miller | Nat Rev Neurosci | 2004 | 14735117 | No |
| 3393 | 1031 | 1031.0 | 21.06 | 21.1 | mTOR and cancer: insights into a complex relationship. | David M Sabatini | Nat Rev Cancer | 2006 | 16915295 | No |
| 3394 | 3091 | 1030.3 | 80.07 | 26.7 | Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions. | M Piotto, V Saudek, V Sklenár | J Biomol NMR | 1992 | 1490109 | Yes |
| 3395 | 2060 | 1030.0 | 86.22 | 43.1 | Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. | L A Clark, D Watson | J Abnorm Psychol | 1991 | 1918611 | No |
| 3396 | 1030 | 1030.0 | 0.0 | 0.0 | Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. | J Ott | Am J Hum Genet | 1974 | 4422075 | Yes |
| 3397 | 1030 | 1030.0 | 25.5 | 25.5 | Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures. | Frank Würthner | Chem Commun (Camb) | 2004 | 15263926 | Yes |
| 3398 | 1030 | 1030.0 | 25.11 | 25.1 | Anatomy and regulation of the central melanocortin system. | Roger D Cone | Nat Neurosci | 2005 | 15856065 | No |
| 3399 | 1030 | 1030.0 | 35.22 | 35.2 | Clinical practice. Endometriosis. | Linda C Giudice | N Engl J Med | 2010 | 20573927 | No |
| 3400 | 2060 | 1030.0 | 71.02 | 35.5 | DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI. | Yan Chao-Gan, Zang Yu-Feng | Front Syst Neurosci | 2010 | 20577591 | Yes |
| 3401 | 3089 | 1029.7 | 80.2 | 26.7 | Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). | R S Spielman, R E McGinnis, W J Ewens | Am J Hum Genet | 1993 | 8447318 | Yes |
| 3402 | 2059 | 1029.5 | 43.22 | 21.6 | Of mice and not men: differences between mouse and human immunology. | Javier Mestas, Christopher C W Hughes | J Immunol | 2004 | 14978070 | No |
| 3403 | 1029 | 1029.0 | 29.14 | 29.1 | Sarcopenia: origins and clinical relevance. | I H Rosenberg | J Nutr | 1997 | 9164280 | No |
| 3404 | 4116 | 1029.0 | 196.49 | 49.1 | Progressive statistics for studies in sports medicine and exercise science. | William G Hopkins, Stephen W Marshall, Alan M Batterham, Juri Hanin | Med Sci Sports Exerc | 2009 | 19092709 | No |
| 3405 | 2057 | 1028.5 | 59.49 | 29.7 | A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions. | Yan Zhao, Donald G Truhlar | J Chem Phys | 2006 | 17129083 | Yes |
| 3406 | 3082 | 1027.3 | 134.27 | 44.8 | Measurement of health status. Ascertaining the minimal clinically important difference. | R Jaeschke, J Singer, G H Guyatt | Control Clin Trials | 1989 | 2691207 | Yes |
| 3407 | 2054 | 1027.0 | 42.28 | 21.1 | Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. | P E Wright, H J Dyson | J Mol Biol | 1999 | 10550212 | No |
| 3408 | 1027 | 1027.0 | 27.88 | 27.9 | A theory of magnitude: common cortical metrics of time, space and quantity. | Vincent Walsh | Trends Cogn Sci | 2003 | 14585444 | Yes |
| 3409 | 1027 | 1027.0 | 23.37 | 23.4 | Sustainable hydrogen production. | John A Turner | Science | 2004 | 15310892 | Yes |
| 3410 | 1027 | 1027.0 | 28.25 | 28.2 | The complex role of estrogens in inflammation. | Rainer H Straub | Endocr Rev | 2007 | 17640948 | No |
| 3411 | 1027 | 1027.0 | 24.29 | 24.3 | Personal genomes: The case of the missing heritability. | Brendan Maher | Nature | 2008 | 18987709 | No |
| 3412 | 1026 | 1026.0 | 0.0 | 0.0 | Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4332694 | Yes |
| 3413 | 1026 | 1026.0 | 0.0 | 0.0 | The influence of immunologically committed lymphoid cells on macrophage activity in vivo. | G B Mackaness | J Exp Med | 1969 | 4976110 | Yes |
| 3414 | 4104 | 1026.0 | 107.15 | 26.8 | A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. | I Vermes, C Haanen, H Steffens-Nakken, C Reutelingsperger | J Immunol Methods | 1995 | 7622868 | Yes |
| 3415 | 1026 | 1026.0 | 33.84 | 33.8 | Predictors of postpartum depression: an update. | C T Beck | Nurs Res | 2001 | 11570712 | Yes |
| 3416 | 1026 | 1026.0 | 23.93 | 23.9 | Natural history of chronic hepatitis C. | Leonard B Seeff | Hepatology | 2002 | 12407575 | No |
| 3417 | 2052 | 1026.0 | 44.84 | 22.4 | Protein aggregation and neurodegenerative disease. | Christopher A Ross, Michelle A Poirier | Nat Med | 2004 | 15272267 | No |
| 3418 | 1026 | 1026.0 | 0.0 | 0.0 | Connections of the cerebral cortex; the albino rat; topography of the cortical areas. | W J S Krieg | J Comp Neurol | 1946 | 20982805 | Yes |
| 3419 | 2051 | 1025.5 | 77.59 | 38.8 | The Modified Mini-Mental State (3MS) examination. | E L Teng, H C Chui | J Clin Psychiatry | 1987 | 3611032 | Yes |
| 3420 | 1025 | 1025.0 | 0.0 | 0.0 | The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle. | M Jouvet | Ergeb Physiol | 1972 | 4403272 | Yes |
| 3421 | 2050 | 1025.0 | 92.83 | 46.4 | Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. | J B Mulliken, J Glowacki | Plast Reconstr Surg | 1982 | 7063565 | Yes |
| 3422 | 4100 | 1025.0 | 120.03 | 30.0 | Biological identifications through DNA barcodes. | Paul D N Hebert, Alina Cywinska, Shelley L Ball, Jeremy R deWaard | Proc Biol Sci | 2003 | 12614582 | Yes |
| 3423 | 1025 | 1025.0 | 22.07 | 22.1 | Oxidant signals and oxidative stress. | Toren Finkel | Curr Opin Cell Biol | 2003 | 12648682 | No |
| 3424 | 1025 | 1025.0 | 25.25 | 25.2 | Differential projections of the infralimbic and prelimbic cortex in the rat. | Robert P Vertes | Synapse | 2004 | 14579424 | Yes |
| 3425 | 2049 | 1024.5 | 77.89 | 38.9 | Understanding face recognition. | V Bruce, A Young | Br J Psychol | 1986 | 3756376 | Yes |
| 3426 | 2049 | 1024.5 | 63.6 | 31.8 | Multiple significance tests: the Bonferroni method. | J M Bland, D G Altman | BMJ | 1995 | 7833759 | Yes |
| 3427 | 2049 | 1024.5 | 70.07 | 35.0 | Efficacy of the Theory of Planned Behaviour: a meta-analytic review. | C J Armitage, M Conner | Br J Soc Psychol | 2001 | 11795063 | Yes |
| 3428 | 3073 | 1024.3 | 94.24 | 31.4 | Regulation of cancer cell metabolism. | Rob A Cairns, Isaac S Harris, Tak W Mak | Nat Rev Cancer | 2011 | 21258394 | No |
| 3429 | 1024 | 1024.0 | 29.34 | 29.3 | Hepatitis B virus. The major etiology of hepatocellular carcinoma. | R P Beasley | Cancer | 1988 | 2834034 | No |
| 3430 | 1024 | 1024.0 | 32.57 | 32.6 | Selective modification of glutathione metabolism. | A Meister | Science | 1983 | 6836290 | Yes |
| 3431 | 1024 | 1024.0 | 28.35 | 28.4 | Presynaptic nicotinic ACh receptors. | S Wonnacott | Trends Neurosci | 1997 | 9023878 | No |
| 3432 | 1024 | 1024.0 | 24.28 | 24.3 | The prefrontal cortex--an update: time is of the essence. | J M Fuster | Neuron | 2001 | 11394996 | No |
| 3433 | 2048 | 1024.0 | 46.94 | 23.5 | Deep tissue two-photon microscopy. | Fritjof Helmchen, Winfried Denk | Nat Methods | 2005 | 16299478 | No |
| 3434 | 1024 | 1024.0 | 25.26 | 25.3 | Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. | William C Aird | Circ Res | 2007 | 17272818 | No |
| 3435 | 2046 | 1023.0 | 42.42 | 21.2 | In search of the 'missing self': MHC molecules and NK cell recognition. | H G Ljunggren, K Kärre | Immunol Today | 1990 | 2201309 | No |
| 3436 | 1023 | 1023.0 | 0.0 | 0.0 | The role of calcium in the release of neurotransmitter substances and hormones. | R P Rubin | Pharmacol Rev | 1970 | 4322219 | No |
| 3437 | 4092 | 1023.0 | 137.1 | 34.3 | Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. | W Vale, J Spiess, C Rivier, J Rivier | Science | 1981 | 6267699 | Yes |
| 3438 | 8180 | 1022.5 | 324.39 | 40.5 | Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. | R C Kessler, K A McGonagle, S Zhao, C B Nelson, M Hughes, S Eshleman, H U Wittchen, K S Kendler | Arch Gen Psychiatry | 1994 | 8279933 | Yes |
| 3439 | 3067 | 1022.3 | 88.32 | 29.4 | Spirometric reference values from a sample of the general U.S. population. | J L Hankinson, J R Odencrantz, K B Fedan | Am J Respir Crit Care Med | 1999 | 9872837 | Yes |
| 3440 | 2044 | 1022.0 | 0.0 | 0.0 | Analysis of probability as an aid in the clinical diagnosis of coronary-artery disease. | G A Diamond, J S Forrester | N Engl J Med | 1979 | 440357 | Yes |
| 3441 | 1022 | 1022.0 | 35.11 | 35.1 | Lipid peroxidation and antioxidants as biomarkers of tissue damage. | J M Gutteridge | Clin Chem | 1995 | 7497639 | No |
| 3442 | 1022 | 1022.0 | 28.37 | 28.4 | Prostaglandin synthase 2. | H R Herschman | Biochim Biophys Acta | 1996 | 8555245 | No |
| 3443 | 1022 | 1022.0 | 0.0 | 0.0 | Regional blood flow by fractional distribution of indicators. | L A Sapirstein | Am J Physiol | 1958 | 13521003 | Yes |
| 3444 | 1022 | 1022.0 | 40.37 | 40.4 | Function and information content of DNA methylation. | Dirk Schübeler | Nature | 2015 | 25592537 | No |
| 3445 | 3065 | 1021.7 | 65.63 | 21.9 | TGF-beta signalling from cell membrane to nucleus through SMAD proteins. | C H Heldin, K Miyazono, P ten Dijke | Nature | 1997 | 9393997 | No |
| 3446 | 1021 | 1021.0 | 50.28 | 50.3 | Self-discrepancy: a theory relating self and affect. | E T Higgins | Psychol Rev | 1987 | 3615707 | Yes |
| 3447 | 3063 | 1021.0 | 89.67 | 29.9 | A sensitive and reliable locomotor rating scale for open field testing in rats. | D M Basso, M S Beattie, J C Bresnahan | J Neurotrauma | 1995 | 7783230 | Yes |
| 3448 | 1021 | 1021.0 | 37.08 | 37.1 | Methods for dealing with reaction time outliers. | R Ratcliff | Psychol Bull | 1993 | 8272468 | Yes |
| 3449 | 1021 | 1021.0 | 32.14 | 32.1 | Atomic layer deposition: an overview. | Steven M George | Chem Rev | 2010 | 19947596 | Yes |
| 3450 | 3062 | 1020.7 | 61.43 | 20.5 | Genetic instabilities in human cancers. | C Lengauer, K W Kinzler, B Vogelstein | Nature | 1998 | 9872311 | No |
| 3451 | 2041 | 1020.5 | 82.77 | 41.4 | A simple method to assess exercise behavior in the community. | G Godin, R J Shephard | Can J Appl Sport Sci | 1985 | 4053261 | Yes |
| 3452 | 2041 | 1020.5 | 45.48 | 22.7 | Roles of CHOP/GADD153 in endoplasmic reticulum stress. | S Oyadomari, M Mori | Cell Death Differ | 2004 | 14685163 | No |
| 3453 | 2041 | 1020.5 | 63.56 | 31.8 | Heterogeneous photocatalyst materials for water splitting. | Akihiko Kudo, Yugo Miseki | Chem Soc Rev | 2009 | 19088977 | Yes |
| 3454 | 3061 | 1020.3 | 87.7 | 29.2 | Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. | Robert G Hart, Lesly A Pearce, Maria I Aguilar | Ann Intern Med | 2007 | 17577005 | Yes |
| 3455 | 2039 | 1019.5 | 73.59 | 36.8 | A simple index of Crohn's-disease activity. | R F Harvey, J M Bradshaw | Lancet | 1980 | 6102236 | Yes |
| 3456 | 1019 | 1019.0 | 38.2 | 38.2 | Spin trapping: ESR parameters of spin adducts. | G R Buettner | Free Radic Biol Med | 1987 | 2826304 | No |
| 3457 | 1019 | 1019.0 | 0.0 | 0.0 | Presidental address. Neuropathological aspects of brain edema. | I Klatzo | J Neuropathol Exp Neurol | 1967 | 5336776 | No |
| 3458 | 2038 | 1019.0 | 36.67 | 18.3 | A synthetic oscillatory network of transcriptional regulators. | M B Elowitz, S Leibler | Nature | 2000 | 10659856 | Yes |
| 3459 | 1019 | 1019.0 | 26.87 | 26.9 | The potential environmental impact of engineered nanomaterials. | Vicki L Colvin | Nat Biotechnol | 2003 | 14520401 | Yes |
| 3460 | 2038 | 1019.0 | 47.55 | 23.8 | microRNA functions. | Natascha Bushati, Stephen M Cohen | Annu Rev Cell Dev Biol | 2007 | 17506695 | No |
| 3461 | 2037 | 1018.5 | 0.0 | 0.0 | Role of cell shape in growth control. | J Folkman, A Moscona | Nature | 1978 | 661946 | Yes |
| 3462 | 1018 | 1018.0 | 21.26 | 21.3 | Resolution of phase ambiguity in macromolecular crystallography. | B C Wang | Methods Enzymol | 1985 | 4079800 | Yes |
| 3463 | 1018 | 1018.0 | 34.8 | 34.8 | Why we need observational studies to evaluate the effectiveness of health care. | N Black | BMJ | 1996 | 8634569 | Yes |
| 3464 | 1018 | 1018.0 | 0.0 | 0.0 | Simplified Myeloperoxidase Stain Using Benzidine Dihydrochloride. | L S Kaplow | Blood | 1965 | 14332483 | Yes |
| 3465 | 1018 | 1018.0 | 25.03 | 25.0 | Nitric oxide, oxidants, and protein tyrosine nitration. | Rafael Radi | Proc Natl Acad Sci U S A | 2004 | 15020765 | Yes |
| 3466 | 2035 | 1017.5 | 46.6 | 23.3 | Regulation of translation initiation in eukaryotes: mechanisms and biological targets. | Nahum Sonenberg, Alan G Hinnebusch | Cell | 2009 | 19239892 | No |
| 3467 | 3052 | 1017.3 | 113.07 | 37.7 | Neighborhoods and violent crime: a multilevel study of collective efficacy. | R J Sampson, S W Raudenbush, F Earls | Science | 1997 | 9252316 | Yes |
| 3468 | 1017 | 1017.0 | 0.0 | 0.0 | Evolution of ageing. | T B Kirkwood | Nature | 1977 | 593350 | Yes |
| 3469 | 1017 | 1017.0 | 31.14 | 31.1 | Spatially heterogeneous dynamics in supercooled liquids. | M D Ediger | Annu Rev Phys Chem | 2000 | 11031277 | Yes |
| 3470 | 1017 | 1017.0 | 28.99 | 29.0 | On the utility of P3 amplitude as a measure of processing capacity. | A Kok | Psychophysiology | 2001 | 11352145 | No |
| 3471 | 1017 | 1017.0 | 22.92 | 22.9 | Serine protease mechanism and specificity. | Lizbeth Hedstrom | Chem Rev | 2002 | 12475199 | No |
| 3472 | 1017 | 1017.0 | 26.97 | 27.0 | Targeting DNA topoisomerase II in cancer chemotherapy. | John L Nitiss | Nat Rev Cancer | 2009 | 19377506 | No |
| 3473 | 6099 | 1016.5 | 144.42 | 24.1 | Principal components analysis corrects for stratification in genome-wide association studies. | Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David Reich | Nat Genet | 2006 | 16862161 | Yes |
| 3474 | 1016 | 1016.0 | 38.87 | 38.9 | The ovariectomized rat model of postmenopausal bone loss. | D N Kalu | Bone Miner | 1991 | 1773131 | No |
| 3475 | 1016 | 1016.0 | 22.17 | 22.2 | Potential metal-binding domains in nucleic acid binding proteins. | J M Berg | Science | 1986 | 2421409 | Yes |
| 3476 | 1016 | 1016.0 | 17.6 | 17.6 | Functional inactivation of genes by dominant negative mutations. | I Herskowitz | Nature | 1987 | 2442619 | No |
| 3477 | 1016 | 1016.0 | 25.71 | 25.7 | Anti-inflammatory actions of glucocorticoids: molecular mechanisms. | P J Barnes | Clin Sci (Lond) | 1998 | 9854452 | No |
| 3478 | 1016 | 1016.0 | 26.82 | 26.8 | Glutathione and its role in cellular functions. | H Sies | Free Radic Biol Med | 1999 | 10569624 | No |
| 3479 | 1016 | 1016.0 | 0.0 | 0.0 | Fluorescent antibody methods. | A H Coons | Gen Cytochem Methods | 1958 | 13574437 | Yes |
| 3480 | 3048 | 1016.0 | 86.0 | 28.7 | Fast model-based estimation of ancestry in unrelated individuals. | David H Alexander, John Novembre, Kenneth Lange | Genome Res | 2009 | 19648217 | Yes |
| 3481 | 6094 | 1015.7 | 160.35 | 26.7 | Ghrelin is a growth-hormone-releasing acylated peptide from stomach. | M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K Kangawa | Nature | 1999 | 10604470 | Yes |
| 3482 | 2031 | 1015.5 | 60.57 | 30.3 | Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. | C N Hales, D J Barker | Diabetologia | 1992 | 1644236 | No |
| 3483 | 2031 | 1015.5 | 56.12 | 28.1 | Fitness effects on the cognitive function of older adults: a meta-analytic study. | Stanley Colcombe, Arthur F Kramer | Psychol Sci | 2003 | 12661673 | Yes |
| 3484 | 3046 | 1015.3 | 74.62 | 24.9 | Nitric oxide and macrophage function. | J MacMicking, Q W Xie, C Nathan | Annu Rev Immunol | 1997 | 9143691 | No |
| 3485 | 1015 | 1015.0 | 35.54 | 35.5 | Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance. | M D Majewska | Prog Neurobiol | 1992 | 1349441 | No |
| 3486 | 1015 | 1015.0 | 29.02 | 29.0 | Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease. | W J Welch | Physiol Rev | 1992 | 1438579 | No |
| 3487 | 1015 | 1015.0 | 30.03 | 30.0 | Cytochrome oxidase: an endogenous metabolic marker for neuronal activity. | M T Wong-Riley | Trends Neurosci | 1989 | 2469224 | No |
| 3488 | 2030 | 1015.0 | 80.43 | 40.2 | Glutathione reductase. | I Carlberg, B Mannervik | Methods Enzymol | 1985 | 3003504 | Yes |
| 3489 | 1015 | 1015.0 | 31.78 | 31.8 | Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion. | E Falk | Circulation | 1985 | 3971539 | Yes |
| 3490 | 1015 | 1015.0 | 19.88 | 19.9 | Initiation of translation in prokaryotes and eukaryotes. | M Kozak | Gene | 1999 | 10395892 | No |
| 3491 | 1015 | 1015.0 | 26.44 | 26.4 | Pathogenesis of osteoporosis: concepts, conflicts, and prospects. | Lawrence G Raisz | J Clin Invest | 2005 | 16322775 | No |
| 3492 | 2029 | 1014.5 | 0.0 | 0.0 | Fine structural localization of a blood-brain barrier to exogenous peroxidase. | T S Reese, M J Karnovsky | J Cell Biol | 1967 | 6033532 | Yes |
| 3493 | 2029 | 1014.5 | 54.56 | 27.3 | Compilation and analysis of Escherichia coli promoter DNA sequences. | D K Hawley, W R McClure | Nucleic Acids Res | 1983 | 6344016 | No |
| 3494 | 2029 | 1014.5 | 58.07 | 29.0 | BODIPY dyes and their derivatives: syntheses and spectroscopic properties. | Aurore Loudet, Kevin Burgess | Chem Rev | 2007 | 17924696 | Yes |
| 3495 | 2029 | 1014.5 | 85.84 | 42.9 | Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. | Susan Whitfield-Gabrieli, Alfonso Nieto-Castanon | Brain Connect | 2012 | 22642651 | Yes |
| 3496 | 3043 | 1014.3 | 106.49 | 35.5 | Job burnout. | C Maslach, W B Schaufeli, M P Leiter | Annu Rev Psychol | 2001 | 11148311 | Yes |
| 3497 | 3042 | 1014.0 | 62.99 | 21.0 | The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. | W H Landschulz, P F Johnson, S L McKnight | Science | 1988 | 3289117 | Yes |
| 3498 | 1014 | 1014.0 | 32.41 | 32.4 | Food reward: brain substrates of wanting and liking. | K C Berridge | Neurosci Biobehav Rev | 1996 | 8622814 | No |
| 3499 | 9126 | 1014.0 | 259.33 | 28.8 | MolProbity: all-atom structure validation for macromolecular crystallography. | Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C Richardson | Acta Crystallogr D Biol Crystallogr | 2010 | 20057044 | Yes |
| 3500 | 1014 | 1014.0 | 43.99 | 44.0 | A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading. | Cathy J Price | Neuroimage | 2012 | 22584224 | No |
| 3501 | 2027 | 1013.5 | 64.11 | 32.1 | Strategies in the design of nanoparticles for therapeutic applications. | Robby A Petros, Joseph M DeSimone | Nat Rev Drug Discov | 2010 | 20616808 | No |
| 3502 | 10133 | 1013.3 | 243.21 | 24.3 | Scalable molecular dynamics with NAMD. | James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kalé, Klaus Schulten | J Comput Chem | 2005 | 16222654 | Yes |
| 3503 | 1013 | 1013.0 | 0.0 | 0.0 | Vagal sensory receptors and their reflex effects. | A S Paintal | Physiol Rev | 1973 | 4568412 | No |
| 3504 | 1013 | 1013.0 | 29.73 | 29.7 | Targeting recovery: priorities of the spinal cord-injured population. | Kim D Anderson | J Neurotrauma | 2004 | 15672628 | Yes |
| 3505 | 1013 | 1013.0 | 0.0 | 0.0 | Histological and histochemical uses of periodic acid. | J F A McMANUS | Stain Technol | 1948 | 18867618 | Yes |
| 3506 | 2025 | 1012.5 | 40.47 | 20.2 | Cellular functions regulated by Src family kinases. | S M Thomas, J S Brugge | Annu Rev Cell Dev Biol | 1997 | 9442882 | No |
| 3507 | 2025 | 1012.5 | 49.89 | 24.9 | Endometriosis. | Linda C Giudice, Lee C Kao | Lancet | 2004 | 15541453 | No |
| 3508 | 1012 | 1012.0 | 25.87 | 25.9 | Molten globule and protein folding. | O B Ptitsyn | Adv Protein Chem | 1995 | 8561052 | No |
| 3509 | 1012 | 1012.0 | 18.79 | 18.8 | Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. | R A Frye | Biochem Biophys Res Commun | 2000 | 10873683 | Yes |
| 3510 | 1012 | 1012.0 | 29.82 | 29.8 | The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. | S Nolen-Hoeksema | J Abnorm Psychol | 2000 | 11016119 | Yes |
| 3511 | 1012 | 1012.0 | 19.16 | 19.2 | NFAT proteins: key regulators of T-cell development and function. | Fernando Macian | Nat Rev Immunol | 2005 | 15928679 | No |
| 3512 | 6071 | 1011.8 | 189.75 | 31.6 | Prevalence of overweight and obesity in the United States, 1999-2004. | Cynthia L Ogden, Margaret D Carroll, Lester R Curtin, Margaret A McDowell, Carolyn J Tabak, Katherine M Flegal | JAMA | 2006 | 16595758 | Yes |
| 3513 | 1011 | 1011.0 | 53.67 | 53.7 | Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem. | P D Henry | Am J Cardiol | 1980 | 6255787 | No |
| 3514 | 1011 | 1011.0 | 26.19 | 26.2 | Skeletal complications of malignancy. | R E Coleman | Cancer | 1997 | 9362426 | No |
| 3515 | 1011 | 1011.0 | 24.2 | 24.2 | Atherosclerosis is an inflammatory disease. | R Ross | Am Heart J | 1999 | 10539839 | No |
| 3516 | 1011 | 1011.0 | 33.17 | 33.2 | Isolation By Distance In Equilibrium And Non-Equilibrium Populations. | Montgomery Slatkin | Evolution | 1993 | 28568097 | Yes |
| 3517 | 3032 | 1010.7 | 0.0 | 0.0 | Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose. | P L Ey, S J Prowse, C R Jenkin | Immunochemistry | 1978 | 30693 | Yes |
| 3518 | 4041 | 1010.2 | 100.37 | 25.1 | The epidemiology of sepsis in the United States from 1979 through 2000. | Greg S Martin, David M Mannino, Stephanie Eaton, Marc Moss | N Engl J Med | 2003 | 12700374 | Yes |
| 3519 | 1010 | 1010.0 | 29.49 | 29.5 | Nitric oxide synthase structure and mechanism. | M A Marletta | J Biol Chem | 1993 | 7685338 | No |
| 3520 | 1010 | 1010.0 | 31.79 | 31.8 | Prevention of drug access to bacterial targets: permeability barriers and active efflux. | H Nikaido | Science | 1994 | 8153625 | No |
| 3521 | 2019 | 1009.5 | 47.27 | 23.6 | Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. | Daniel J Hicklin, Lee M Ellis | J Clin Oncol | 2005 | 15585754 | No |
| 3522 | 2018 | 1009.0 | 0.0 | 0.0 | Comparative aspects of the brain growth spurt. | J Dobbing, J Sands | Early Hum Dev | 1979 | 118862 | Yes |
| 3523 | 1009 | 1009.0 | 28.33 | 28.3 | The role of protein phosphorylation in neural and hormonal control of cellular activity. | P Cohen | Nature | 1982 | 6280056 | No |
| 3524 | 1009 | 1009.0 | 28.83 | 28.8 | Ion suppression in mass spectrometry. | Thomas M Annesley | Clin Chem | 2003 | 12816898 | No |
| 3525 | 5042 | 1008.4 | 147.69 | 29.5 | Quantitative assessment of tactile allodynia in the rat paw. | S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L Yaksh | J Neurosci Methods | 1994 | 7990513 | Yes |
| 3526 | 3025 | 1008.3 | 83.41 | 27.8 | The widespread regulation of microRNA biogenesis, function and decay. | Jacek Krol, Inga Loedige, Witold Filipowicz | Nat Rev Genet | 2010 | 20661255 | No |
| 3527 | 1008 | 1008.0 | 31.67 | 31.7 | Topography of cognition: parallel distributed networks in primate association cortex. | P S Goldman-Rakic | Annu Rev Neurosci | 1988 | 3284439 | No |
| 3528 | 1008 | 1008.0 | 0.0 | 0.0 | Isolation of an organ specific protein antigen from cell-surface membrane of rat liver. | D M Neville | Biochim Biophys Acta | 1968 | 4967807 | Yes |
| 3529 | 2016 | 1008.0 | 0.0 | 0.0 | The period of susceptibility to the physiological effects of unilateral eye closure in kittens. | D H Hubel, T N Wiesel | J Physiol | 1970 | 5498493 | Yes |
| 3530 | 1008 | 1008.0 | 38.17 | 38.2 | Cellular mechanisms of muscle fatigue. | R H Fitts | Physiol Rev | 1994 | 8295935 | No |
| 3531 | 1008 | 1008.0 | 24.0 | 24.0 | BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data. | O Gascuel | Mol Biol Evol | 1997 | 9254330 | Yes |
| 3532 | 1008 | 1008.0 | 25.47 | 25.5 | Biological effects of resveratrol. | L Frémont | Life Sci | 2000 | 10680575 | No |
| 3533 | 1008 | 1008.0 | 27.59 | 27.6 | Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. | Michael F Holick | Am J Clin Nutr | 2004 | 14985208 | No |
| 3534 | 2015 | 1007.5 | 52.61 | 26.3 | Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. | M Tsujii, R N DuBois | Cell | 1995 | 8521479 | Yes |
| 3535 | 6044 | 1007.3 | 137.15 | 22.9 | Obesity is associated with macrophage accumulation in adipose tissue. | Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W Ferrante | J Clin Invest | 2003 | 14679176 | Yes |
Download as CSV