Unicorn Papers

Top ‱ cited papers from PUBMED

Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authors
Currently, the list contains 3510 papers with ECcit ≥ 1000.0
‱ - permyriad, , literally meaning "for (every) myriad (ten thousand)"

Volume 18, February 2022

No. Citations ECcit RCR ECRCR Title Authors Journal Year PMID Article(?)
1221804221804.00.00.0Cleavage of structural proteins during the assembly of the head of bacteriophage T4. U K LaemmliNature19705432063Yes
2168697168697.00.00.0A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. M M BradfordAnal Biochem1976942051Yes
328520671301.50.00.0Protein measurement with the Folin phenol reagent. O H Lowry, N J Rosebrough, A L Farr, R J RandallJ Biol Chem195114907713Yes
49820449102.02526.061263.0Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. K J Livak, T D SchmittgenMethods200111846609Yes
54314143141.01446.681446.7A short history of SHELX. George M SheldrickActa Crystallogr A200818156677Yes
63385133851.01100.181100.2Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. T MosmannJ Immunol Methods19836606682Yes
76509732548.51973.94987.0Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. P Chomczynski, N SacchiAnal Biochem19872440339Yes
83018030180.00.00.0Detection of specific sequences among DNA fragments separated by gel electrophoresis. E M SouthernJ Mol Biol19751195397Yes
92556125561.00.00.0The assessment and analysis of handedness: the Edinburgh inventory. R C OldfieldNeuropsychologia19715146491Yes
102514825148.0580.77580.8MicroRNAs: genomics, biogenesis, mechanism, and function. David P BartelCell200414744438No
112376223762.00.00.0A rating scale for depression. M HamiltonJ Neurol Neurosurg Psychiatry196014399272Yes
122256522565.0708.14708.1Confidence Limits On Phylogenies: An Approach Using The Bootstrap. Joseph FelsensteinEvolution198528561359Yes
132195821958.0544.05544.0MUSCLE: multiple sequence alignment with high accuracy and high throughput. Robert C EdgarNucleic Acids Res200415034147Yes
146540221800.70.00.0DNA sequencing with chain-terminating inhibitors. F Sanger, S Nicklen, A R CoulsonProc Natl Acad Sci U S A1977271968Yes
152168721687.0515.88515.9A new mathematical model for relative quantification in real-time RT-PCR. M W PfafflNucleic Acids Res200111328886Yes
166066820222.70.00.0"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. M F Folstein, S E Folstein, P R McHughJ Psychiatr Res19751202204Yes
171996819968.00.00.0The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. E S ReynoldsJ Cell Biol196313986422Yes
183699318496.51148.54574.3The neighbor-joining method: a new method for reconstructing phylogenetic trees. N Saitou, M NeiMol Biol Evol19873447015Yes
191846718467.0656.0656.0Density-functional exchange-energy approximation with correct asymptotic behavior. BeckePhys Rev A Gen Phys19889900728Yes
201822318223.00.00.0Tissue sulfhydryl groups. G L EllmanArch Biochem Biophys195913650640Yes
215316917723.00.00.0Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. H Towbin, T Staehelin, J GordonProc Natl Acad Sci U S A1979388439Yes
221679616796.00.00.0Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. B J DavisAnn N Y Acad Sci196414240539Yes
233350616753.01619.66809.8Statistical methods for assessing agreement between two methods of clinical measurement. J M Bland, D G AltmanLancet19862868172Yes
243330916654.51173.6586.8Hallmarks of cancer: the next generation. Douglas Hanahan, Robert A WeinbergCell201121376230No
251631216312.00.00.0High resolution two-dimensional electrophoresis of proteins. P H O'FarrellJ Biol Chem1975236308Yes
261616016160.0420.18420.2Atherosclerosis--an inflammatory disease. R RossN Engl J Med19999887164No
271589815898.00.00.0A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. K BurtonBiochem J195613293190Yes
281550615506.0579.57579.6A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. M KimuraJ Mol Evol19807463489Yes
293075215376.00.00.0A rapid method of total lipid extraction and purification. E G Bligh, W J DyerCan J Biochem Physiol195913671378Yes
302955114775.50.00.0The measurement of observer agreement for categorical data. J R Landis, G G KochBiometrics1977843571Yes
314350914503.01257.01419.0CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. J D Thompson, D G Higgins, T J GibsonNucleic Acids Res19947984417Yes
324100413668.00.00.0A simple method for the isolation and purification of total lipides from animal tissues. J Folch, M Lees, G H Sloane StanleyJ Biol Chem195713428781Yes
331362413624.0372.68372.7MicroRNAs: target recognition and regulatory functions. David P BartelCell200919167326No
341331413314.0393.72393.7Projector augmented-wave method. BlöchlPhys Rev B Condens Matter19949976227Yes
351310013100.0553.48553.5A power primer. J CohenPsychol Bull199219565683Yes
362596312981.5999.01499.5Meta-analysis in clinical trials. R DerSimonian, N LairdControl Clin Trials19863802833Yes
372538812694.01054.42527.2The hospital anxiety and depression scale. A S Zigmond, R P SnaithActa Psychiatr Scand19836880820Yes
381266012660.00.00.0Phosphorus assay in column chromatography. G R BartlettJ Biol Chem195913641241Yes
391222712227.0485.44485.4Catalase in vitro. H AebiMethods Enzymol19846727660Yes
401207912079.0624.1624.1RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Alexandros StamatakisBioinformatics201424451623Yes
413434111447.01065.59355.2Generalized Gradient Approximation Made Simple. Perdew, Burke, ErnzerhofPhys Rev Lett199610062328Yes
425605411210.81620.8324.2Basic local alignment search tool. S F Altschul, W Gish, W Miller, E W Myers, D J LipmanJ Mol Biol19902231712Yes
432218911094.5937.56468.8The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. J E Ware, C D SherbourneMed Care19921593914Yes
443265110883.71194.44398.1Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. Lee, Yang, ParrPhys Rev B Condens Matter19889944570Yes
452172410862.0477.49238.7Coot: model-building tools for molecular graphics. Paul Emsley, Kevin CowtanActa Crystallogr D Biol Crystallogr200415572765Yes
462156810784.0562.91281.5A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. A P Feinberg, B VogelsteinAnal Biochem19836312838Yes
472141010705.0592.5296.2Fast and accurate short read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics200919451168Yes
481047310473.0354.07354.1Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). J F KurtzkeNeurology19836685237Yes
491032510325.00.00.0Improvements in epoxy resin embedding methods. J H LuftJ Biophys Biochem Cytol196113764136Yes
501017910179.00.00.0The genetics of Caenorhabditis elegans. S BrennerGenetics19744366476Yes
511013710137.0367.7367.7Search and clustering orders of magnitude faster than BLAST. Robert C EdgarBioinformatics201020709691Yes
522019610098.0453.91227.0[20] Processing of X-ray diffraction data collected in oscillation mode. Zbyszek Otwinowski, Wladek MinorMethods Enzymol199727799103Yes
531009010090.0389.27389.3Structure validation in chemical crystallography. Anthony L SpekActa Crystallogr D Biol Crystallogr200919171970Yes
541007010070.0310.9310.9The Psychophysics Toolbox. D H BrainardSpat Vis19979176952Yes
55199359967.5725.89362.9Fast gapped-read alignment with Bowtie 2. Ben Langmead, Steven L SalzbergNat Methods201222388286Yes
56198699934.50.00.0The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. K Weber, M OsbornJ Biol Chem19695806584Yes
5798519851.0281.89281.9Xds. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124692Yes
5897389738.00.00.0Self-efficacy: toward a unifying theory of behavioral change. A BanduraPsychol Rev1977847061Yes
5994849484.0325.09325.1Banting lecture 1988. Role of insulin resistance in human disease. G M ReavenDiabetes19883056758No
6093189318.0366.28366.3A new method for measuring daytime sleepiness: the Epworth sleepiness scale. M W JohnsSleep19911798888Yes
6192499249.0269.78269.8Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. P S ThomasProc Natl Acad Sci U S A19806159641Yes
6292179217.0610.63610.6Crystal structure refinement with SHELXL. George M SheldrickActa Crystallogr C Struct Chem201525567568Yes
6391109110.0243.46243.5Studies on transformation of Escherichia coli with plasmids. D HanahanJ Mol Biol19836345791Yes
64182089104.0478.61239.3A simple method for displaying the hydropathic character of a protein. J Kyte, R F DoolittleJ Mol Biol19827108955Yes
65181299064.5821.08410.5The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. R M Baron, D A KennyJ Pers Soc Psychol19863806354Yes
6690569056.0260.2260.2The pathogenesis of atherosclerosis: a perspective for the 1990s. R RossNature19938479518No
67179558977.5507.67253.8Quantifying heterogeneity in a meta-analysis. Julian P T Higgins, Simon G ThompsonStat Med200212111919Yes
6889518951.0235.94235.9Integrins: versatility, modulation, and signaling in cell adhesion. R O HynesCell19921555235No
69173468673.0503.59251.8Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. Kresse, FurthmüllerPhys Rev B Condens Matter19969984901Yes
7086458645.0189.69189.7Mfold web server for nucleic acid folding and hybridization prediction. Michael ZukerNucleic Acids Res200312824337Yes
7185838583.0245.63245.6Evolutionary trees from DNA sequences: a maximum likelihood approach. J FelsensteinJ Mol Evol19817288891Yes
7285108510.0234.25234.2RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. Alexandros StamatakisBioinformatics200616928733Yes
7384598459.00.00.0On the origin of cancer cells. O WarburgScience195613298683Yes
7483638363.0261.53261.5Vitamin D deficiency. Michael F HolickN Engl J Med200717634462No
75164718235.5359.95180.0The hallmarks of cancer. D Hanahan, R A WeinbergCell200010647931No
76245968198.7656.79218.9VMD: visual molecular dynamics. W Humphrey, A Dalke, K SchultenJ Mol Graph19968744570Yes
7781928192.0174.97175.0Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Gordon K SmythStat Appl Genet Mol Biol200416646809Yes
78322398059.8970.14242.5Measuring inconsistency in meta-analyses. Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G AltmanBMJ200312958120No
7980478047.0360.23360.2Psychophysical bases of perceived exertion. G A BorgMed Sci Sports Exerc19827154893Yes
8079917991.00.00.0Solvent content of protein crystals. B W MatthewsJ Mol Biol19685700707Yes
8178227822.0173.32173.3The functions of animal microRNAs. Victor AmbrosNature200415372042No
8277697769.0218.45218.4The role of protein kinase C in cell surface signal transduction and tumour promotion. Y NishizukaNature19846232463No
8377537753.0218.89218.9"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. W N BurnetteAnal Biochem19816266278Yes
8476957695.00.00.0A simplification of the protein assay method of Lowry et al. which is more generally applicable. G L PetersonAnal Biochem1977603028Yes
85305587639.51306.41326.6Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanPLoS Med200919621072No
8676027602.00.00.0Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. D I ArnonPlant Physiol194916654194Yes
8775857585.0220.26220.3Semiempirical GGA-type density functional constructed with a long-range dispersion correction. Stefan GrimmeJ Comput Chem200616955487Yes
8875767576.00.00.0Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. J R VaneNat New Biol19715284360Yes
8975617561.0205.16205.2Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. M C HochbergArthritis Rheum19979324032Yes
90150327516.0353.26176.6Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Kazutoshi Takahashi, Shinya YamanakaCell200616904174Yes
91298967474.01144.8286.2A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. M E Charlson, P Pompei, K L Ales, C R MacKenzieJ Chronic Dis19873558716Yes
92222347411.3624.1208.0Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Da Wei Huang, Brad T Sherman, Richard A LempickiNat Protoc200919131956Yes
93220877362.3966.43322.1Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Michael I Love, Wolfgang Huber, Simon AndersGenome Biol201425516281Yes
9472507250.00.00.0A low-viscosity epoxy resin embedding medium for electron microscopy. A R SpurrJ Ultrastruct Res19694887011Yes
95214387146.0828.83276.3NIH Image to ImageJ: 25 years of image analysis. Caroline A Schneider, Wayne S Rasband, Kevin W EliceiriNat Methods201222930834No
9671317131.00.00.0Tumor angiogenesis: therapeutic implications. J FolkmanN Engl J Med19714938153No
97142537126.5360.91180.5MrBayes 3: Bayesian phylogenetic inference under mixed models. Fredrik Ronquist, John P HuelsenbeckBioinformatics200312912839Yes
9871147114.0277.97278.0Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Andreas StangEur J Epidemiol201020652370Yes
9970367036.0237.9237.9The blockade of immune checkpoints in cancer immunotherapy. Drew M PardollNat Rev Cancer201222437870No
100280357008.8933.46233.4Bias in meta-analysis detected by a simple, graphical test. M Egger, G Davey Smith, M Schneider, C MinderBMJ19979310563Yes
10170067006.0193.74193.7TreeView: an application to display phylogenetic trees on personal computers. R D PageComput Appl Biosci19968902363Yes
10269906990.00.00.0Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. A BöyumScand J Clin Lab Invest Suppl19684179068Yes
103139216960.5395.89197.9Analyzing real-time PCR data by the comparative C(T) method. Thomas D Schmittgen, Kenneth J LivakNat Protoc200818546601Yes
10469586958.0211.29211.3AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. R W CoxComput Biomed Res19968812068Yes
105208316943.70.00.0Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. W T Friedewald, R I Levy, D S FredricksonClin Chem19724337382Yes
106485246932.01280.35182.9Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J LipmanNucleic Acids Res19979254694No
10769216921.0189.33189.3Canonical dynamics: Equilibrium phase-space distributions. HooverPhys Rev A Gen Phys19859895674Yes
10868826882.0235.24235.2Density-functional approximation for the correlation energy of the inhomogeneous electron gas. PerdewPhys Rev B Condens Matter19869938299Yes
10968516851.0177.06177.1PAML 4: phylogenetic analysis by maximum likelihood. Ziheng YangMol Biol Evol200717483113Yes
11067966796.0155.95155.9Chromatin modifications and their function. Tony KouzaridesCell200717320507No
11167586758.0184.46184.5The steroid and thyroid hormone receptor superfamily. R M EvansScience19883283939No
112134876743.50.00.0Continuous cultures of fused cells secreting antibody of predefined specificity. G Köhler, C MilsteinNature19751172191Yes
11367376737.0182.25182.2Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. F TajimaGenetics19892513255Yes
11467266726.00.00.0The thiobarbituric acid assay of sialic acids. L WarrenJ Biol Chem195913672998Yes
11567156715.0319.04319.0Comparative fit indexes in structural models. P M BentlerPsychol Bull19902320703Yes
116133986699.0288.26144.1 Processing of X-ray diffraction data collected in oscillation mode. Z Otwinowski, W MinorMethods Enzymol199727754618Yes
117132246612.0599.07299.5MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Kazutaka Katoh, Daron M StandleyMol Biol Evol201323329690Yes
118198286609.3565.87188.6A new generation of Ca2+ indicators with greatly improved fluorescence properties. G Grynkiewicz, M Poenie, R Y TsienJ Biol Chem19853838314Yes
119131826591.0304.67152.3Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. S J Clough, A F BentPlant J199810069079Yes
12065266526.00.00.0The assessment of anxiety states by rating. M HamiltonBr J Med Psychol195913638508Yes
121130256512.5289.02144.5KEGG: kyoto encyclopedia of genes and genomes. M Kanehisa, S GotoNucleic Acids Res200010592173Yes
12265066506.0168.3168.3Fast robust automated brain extraction. Stephen M SmithHum Brain Mapp200212391568No
12364976497.0172.51172.5Adhesion receptors of the immune system. T A SpringerNature19901974032No
124194526484.0922.08307.4Trimmomatic: a flexible trimmer for Illumina sequence data. Anthony M Bolger, Marc Lohse, Bjoern UsadelBioinformatics201424695404Yes
12564096409.0304.57304.6Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Y KandaBone Marrow Transplant201323208313Yes
12663966396.0169.55169.6Angiogenesis in cancer, vascular, rheumatoid and other disease. J FolkmanNat Med19957584949No
12763866386.0180.4180.4Apoptosis: a review of programmed cell death. Susan ElmoreToxicol Pathol200717562483No
128127276363.50.00.0Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Y Cheng, W H PrusoffBiochem Pharmacol19734202581Yes
12963586358.0130.16130.2Rapid and efficient site-specific mutagenesis without phenotypic selection. T A KunkelProc Natl Acad Sci U S A19853881765Yes
13063506350.0196.47196.5The VideoToolbox software for visual psychophysics: transforming numbers into movies. D G PelliSpat Vis19979176953Yes
131126056302.50.00.0Statistical aspects of the analysis of data from retrospective studies of disease. N Mantel, W HaenszelJ Natl Cancer Inst195913655060Yes
13262276227.0208.02208.0Ethical guidelines for investigations of experimental pain in conscious animals. Manfred ZimmermannPain19836877845No
13361706170.0135.67135.7p53, the cellular gatekeeper for growth and division. A J LevineCell19979039259No
134122046102.00.00.0A rapid alkaline extraction procedure for screening recombinant plasmid DNA. H C Birnboim, J DolyNucleic Acids Res1979388356Yes
135182606086.71375.58458.5MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Sudhir Kumar, Glen Stecher, Koichiro TamuraMol Biol Evol201627004904Yes
13660356035.0198.57198.6The Clinical Dementia Rating (CDR): current version and scoring rules. J C MorrisNeurology19938232972Yes
13760286028.0150.43150.4Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. T A SpringerCell19947507411No
138240056001.20.00.0Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. J M Chirgwin, A E Przybyla, R J MacDonald, W J RutterBiochemistry1979518835Yes
139119725986.00.00.0Prediction of creatinine clearance from serum creatinine. D W Cockcroft, M H GaultNephron19761244564Yes
14059605960.0152.66152.7Inositol trisphosphate and calcium signalling. M J BerridgeNature19938381210No
14159295929.0123.12123.1Integrins: bidirectional, allosteric signaling machines. Richard O HynesCell200212297042No
14259255925.0152.53152.5G proteins: transducers of receptor-generated signals. A G GilmanAnnu Rev Biochem19873113327No
14358595859.0134.16134.2Inflammation in atherosclerosis. Peter LibbyNature200212490960No
144116555827.50.00.0Intraclass correlations: uses in assessing rater reliability. P E Shrout, J L FleissPsychol Bull197918839484No
14557875787.0144.87144.9Inflammation, atherosclerosis, and coronary artery disease. Göran K HanssonN Engl J Med200515843671No
146114265713.0405.87202.9The meaning and use of the area under a receiver operating characteristic (ROC) curve. J A Hanley, B J McNeilRadiology19827063747Yes
147113855692.50.00.0The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. T Omura, R SatoJ Biol Chem196414209971Yes
14856765676.0139.98140.0Biochemistry and molecular cell biology of diabetic complications. M BrownleeNature200111742414Yes
14956495649.0144.46144.5Apoptosis in the pathogenesis and treatment of disease. C B ThompsonScience19957878464No
15056435643.00.00.0A Self-Rating Depression Scale. W W ZungArch Gen Psychiatry196514221692Yes
15156045604.0137.04137.0Free radicals in the physiological control of cell function. Wulf DrögePhysiol Rev200211773609No
152334875581.23643.99607.3Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin JemalCA Cancer J Clin201830207593Yes
153111295564.5301.43150.7Sequencing end-labeled DNA with base-specific chemical cleavages. A M Maxam, W GilbertMethods Enzymol19806246368Yes
154110365518.0276.69138.3MRBAYES: Bayesian inference of phylogenetic trees. J P Huelsenbeck, F RonquistBioinformatics200111524383Yes
155165445514.7534.15178.0Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Daniel Dindo, Nicolas Demartines, Pierre-Alain ClavienAnn Surg200415273542Yes
156164745491.30.00.0Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. H Ohkawa, N Ohishi, K YagiAnal Biochem197936810Yes
157109755487.5252.07126.0Dendritic cells and the control of immunity. J Banchereau, R M SteinmanNature19989521319No
15854735473.0277.17277.2UPARSE: highly accurate OTU sequences from microbial amplicon reads. Robert C EdgarNat Methods201323955772Yes
15954635463.0198.09198.1The Strengths and Difficulties Questionnaire: a research note. R GoodmanJ Child Psychol Psychiatry19979255702Yes
160108875443.50.00.0A series of normal stages in the development of the chick embryo. V Hamburger, H L HamiltonJ Morphol195124539719Yes
16154325432.00.00.0Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. F TietzeAnal Biochem19694388022Yes
16254265426.0106.63106.6BLAT--the BLAST-like alignment tool. W James KentGenome Res200211932250Yes
16353965396.0299.65299.6Prokka: rapid prokaryotic genome annotation. Torsten SeemannBioinformatics201424642063Yes
164161065368.7473.81157.9edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Mark D Robinson, Davis J McCarthy, Gordon K SmythBioinformatics201019910308Yes
16553575357.0129.56129.6Antimicrobial peptides of multicellular organisms. Michael ZasloffNature200211807545Yes
16653505350.0137.38137.4New M13 vectors for cloning. J MessingMethods Enzymol19836310323Yes
16753395339.00.00.0Modification of seizure activity by electrical stimulation. II. Motor seizure. R J RacineElectroencephalogr Clin Neurophysiol19724110397Yes
16853135313.00.00.0Evaluation of survival data and two new rank order statistics arising in its consideration. N MantelCancer Chemother Rep19665910392Yes
16952945294.0119.15119.2The biochemistry of apoptosis. M O HengartnerNature200011048727No
170105305265.0249.58124.8Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. W Kabsch, C SanderBiopolymers19836667333Yes
17152635263.0142.06142.1The Cambridge Structural Database: a quarter of a million crystal structures and rising. Frank H AllenActa Crystallogr B200212037359Yes
17252575257.0153.43153.4Studies and perspectives of protein kinase C. Y NishizukaScience19863014651No
173157455248.3477.91159.3A simple salting out procedure for extracting DNA from human nucleated cells. S A Miller, D D Dykes, H F PoleskyNucleic Acids Res19883344216Yes
174104725236.0300.72150.4MODELTEST: testing the model of DNA substitution. D Posada, K A CrandallBioinformatics19989918953Yes
17552215221.00.00.0[A micro-method of immuno-electrophoresis]. J J ScheideggerInt Arch Allergy Appl Immunol195513262900Yes
176155715190.3481.53160.5The PHQ-9: validity of a brief depression severity measure. K Kroenke, R L Spitzer, J B WilliamsJ Gen Intern Med200111556941Yes
177103785189.0251.67125.8A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Stéphane Guindon, Olivier GascuelSyst Biol200314530136Yes
17851845184.00.00.0Selective extraction of polyoma DNA from infected mouse cell cultures. B HirtJ Mol Biol19674291934Yes
17951845184.00.00.0The Environment And Disease: Association Or Causation? A B HillProc R Soc Med196514283879Yes
18051705170.0190.58190.6Oxygen-derived free radicals in postischemic tissue injury. J M McCordN Engl J Med19852981404No
18151675167.00.00.0Mutation and cancer: statistical study of retinoblastoma. A G KnudsonProc Natl Acad Sci U S A19715279523Yes
18251635163.0132.92132.9Inflammation and metabolic disorders. Gökhan S HotamisligilNature200617167474No
18351585158.0121.95122.0Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. J CastresanaMol Biol Evol200010742046Yes
184103075153.5373.33186.7Three approaches to qualitative content analysis. Hsiu-Fang Hsieh, Sarah E ShannonQual Health Res200516204405Yes
18551425142.0126.75126.8The NF-kappa B and I kappa B proteins: new discoveries and insights. A S BaldwinAnnu Rev Immunol19968717528No
186256545130.8704.48140.9The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G HigginsNucleic Acids Res19979396791Yes
18751195119.0175.47175.5jModelTest: phylogenetic model averaging. David PosadaMol Biol Evol200818397919Yes
18851185118.00.00.0Aging: a theory based on free radical and radiation chemistry. D HarmanJ Gerontol195613332224Yes
189102065103.0232.77116.4One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. K A Datsenko, B L WannerProc Natl Acad Sci U S A200010829079Yes
19050825082.0207.19207.2Orienting of attention. M I PosnerQ J Exp Psychol19807367577Yes
191101395069.5375.03187.5The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. R F Furchgott, J V ZawadzkiNature19806253831Yes
19250505050.00.00.0Development of a rating scale for primary depressive illness. M HamiltonBr J Soc Clin Psychol19676080235Yes
193100685034.0268.89134.4Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. H Schägger, G von JagowAnal Biochem19872449095Yes
19450095009.0320.09320.1SHELXT - integrated space-group and crystal-structure determination. George M SheldrickActa Crystallogr A Found Adv201525537383Yes
19599934996.5282.66141.3Neuropathological stageing of Alzheimer-related changes. H Braak, E BraakActa Neuropathol19911759558No
19649884988.0184.99185.0Analyzing Tables Of Statistical Tests. William R RiceEvolution198928568501Yes
19749844984.00.00.0A protein binding assay for adenosine 3':5'-cyclic monophosphate. A G GilmanProc Natl Acad Sci U S A19704318781Yes
19849644964.0102.62102.6Rho GTPases and the actin cytoskeleton. A HallScience19989438836No
199148164938.7541.13180.4Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. S M Hsu, L Raine, H FangerJ Histochem Cytochem19816166661Yes
20049274927.00.00.0Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. C B LaurellAnal Biochem19665959431Yes
20149214921.0139.65139.7A modified poisson regression approach to prospective studies with binary data. Guangyong ZouAm J Epidemiol200415033648Yes
20249094909.0100.07100.1Epithelial-mesenchymal transitions in tumour progression. Jean Paul ThieryNat Rev Cancer200212189386No
20397954897.5357.81178.9Ligand: a versatile computerized approach for characterization of ligand-binding systems. P J Munson, D RodbardAnal Biochem19806254391Yes
20497824891.0337.36168.7AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Oleg Trott, Arthur J OlsonJ Comput Chem201019499576Yes
20548714871.0147.51147.5Developments of a water-maze procedure for studying spatial learning in the rat. R MorrisJ Neurosci Methods19846471907Yes
206145184839.3395.94132.0Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. C Yanisch-Perron, J Vieira, J MessingGene19852985470Yes
20796774838.50.00.0A quantitative description of membrane current and its application to conduction and excitation in nerve. A L Hodgkin, A F HuxleyJ Physiol195212991237Yes
20848314831.00.00.0Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. M RodbellJ Biol Chem196414169133Yes
209144774825.7361.59120.5A comprehensive set of sequence analysis programs for the VAX. J Devereux, P Haeberli, O SmithiesNucleic Acids Res19846546423Yes
21096124806.0252.37126.2BEDTools: a flexible suite of utilities for comparing genomic features. Aaron R Quinlan, Ira M HallBioinformatics201020110278Yes
21147794779.097.697.6An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. M KozakNucleic Acids Res19873313277No
21247674767.00.00.0The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. P LaurenActa Pathol Microbiol Scand196514320675Yes
21395324766.0276.49138.2EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Arnaud Delorme, Scott MakeigJ Neurosci Methods200415102499Yes
214142554751.70.00.0Determination of serum proteins by means of the biuret reaction. A G Gornall, C J Bardawill, M M DavidJ Biol Chem194918110453Yes
21547424742.0119.95120.0Emotion circuits in the brain. J E LeDouxAnnu Rev Neurosci200010845062No
21694674733.50.00.0A new technique for the assay of infectivity of human adenovirus 5 DNA. F L Graham, A J van der EbVirology19734705382Yes
217188944723.5661.86165.5G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel BuchnerBehav Res Methods200717695343Yes
21894304715.0229.14114.6Comparative protein modelling by satisfaction of spatial restraints. A Sali, T L BlundellJ Mol Biol19938254673Yes
21946924692.0131.03131.0Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. P MatsudairaJ Biol Chem19873611052Yes
22093514675.5229.74114.9A genetic model for colorectal tumorigenesis. E R Fearon, B VogelsteinCell19902188735No
22193514675.5208.39104.2Inflammation and cancer. Lisa M Coussens, Zena WerbNature200212490959No
22246694669.0107.14107.1ras oncogenes in human cancer: a review. J L BosCancer Res19892547513No
22393384669.0237.99119.0Improved tools for biological sequence comparison. W R Pearson, D J LipmanProc Natl Acad Sci U S A19883162770Yes
22493374668.50.00.0A new depression scale designed to be sensitive to change. S A Montgomery, M AsbergBr J Psychiatry1979444788Yes
22546614661.0158.7158.7The pathogenesis of atherosclerosis--an update. R RossN Engl J Med19863511384No
22646344634.0104.22104.2Cancer cell cycles. C J SherrScience19968939849No
227138824627.3533.62177.9The positive and negative syndrome scale (PANSS) for schizophrenia. S R Kay, A Fiszbein, L A OplerSchizophr Bull19873616518Yes
22846214621.0138.94138.9A fast diffeomorphic image registration algorithm. John AshburnerNeuroimage200717761438Yes
229138544618.0486.47162.2Nitric oxide: physiology, pathophysiology, and pharmacology. S Moncada, R M Palmer, E A HiggsPharmacol Rev19911852778No
23046074607.00.00.0Aggregation of blood platelets by adenosine diphosphate and its reversal. G V BornNature196213871375Yes
23192054602.5209.6104.8The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. John Hardy, Dennis J SelkoeScience200212130773No
23245904590.00.00.0A rapid banding technique for human chromosomes. M SeabrightLancet19714107917Yes
233183574589.2566.21141.6MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir KumarMol Biol Evol200717488738Yes
23445784578.00.00.0Index for rating diagnostic tests. W J YoudenCancer195015405679Yes
23545754575.00.00.0The clonal evolution of tumor cell populations. P C NowellScience1976959840Yes
23645524552.0106.25106.2MUSCLE: a multiple sequence alignment method with reduced time and space complexity. Robert C EdgarBMC Bioinformatics200415318951Yes
23745334533.096.9296.9Targeting HIF-1 for cancer therapy. Gregg L SemenzaNat Rev Cancer200313130303No
238134744491.3302.72100.9Refinement of macromolecular structures by the maximum-likelihood method. G N Murshudov, A A Vagin, E J DodsonActa Crystallogr D Biol Crystallogr199715299926Yes
239224474489.41150.71230.1MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir KumarMol Biol Evol201324132122Yes
24044774477.098.1698.2ras genes. M BarbacidAnnu Rev Biochem19873304147No
241133914463.7340.67113.6Inference of population structure using multilocus genotype data. J K Pritchard, M Stephens, P DonnellyGenetics200010835412Yes
24289204460.00.00.0Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J M McCord, I FridovichJ Biol Chem19695389100Yes
24344594459.0109.66109.7A new method for predicting signal sequence cleavage sites. G von HeijneNucleic Acids Res19863714490Yes
24444574457.00.00.0The McGill Pain Questionnaire: major properties and scoring methods. Ronald MelzackPain19751235985Yes
245222784455.60.00.0An inventory for measuring depression. A T Beck, C H Ward, M Mendelson, J Mock, J ErbaughArch Gen Psychiatry196113688369Yes
24688944447.00.00.0A simplified method of evaluating dose-effect experiments. J T Litchfield, F WilcoxonJ Pharmacol Exp Ther194918152921Yes
24744314431.0101.95102.0Alzheimer's disease: genes, proteins, and therapy. D J SelkoePhysiol Rev200111274343No
24844314431.0124.31124.3Mild cognitive impairment as a diagnostic entity. R C PetersenJ Intern Med200415324362No
24944214421.086.7186.7DNA methylation patterns and epigenetic memory. Adrian BirdGenes Dev200211782440No
25088064403.0297.82148.9Operating characteristics of a rank correlation test for publication bias. C B Begg, M MazumdarBiometrics19947786990Yes
25187884394.00.00.0A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. W M Bonner, R A LaskeyEur J Biochem19744850204Yes
25243794379.00.00.0Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. W H HarrisJ Bone Joint Surg Am19695783851Yes
25387444372.0200.23100.1Primer3 on the WWW for general users and for biologist programmers. S Rozen, H SkaletskyMethods Mol Biol200010547847Yes
25443664366.089.9590.0Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. M KozakCell19863943125Yes
25543634363.0100.68100.7Prions. S B PrusinerProc Natl Acad Sci U S A19989811807No
25687014350.5246.38123.2Differential expression analysis for sequence count data. Simon Anders, Wolfgang HuberGenome Biol201020979621Yes
25743444344.00.00.0Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. M M MesulamJ Histochem Cytochem197824068Yes
25843434343.00.00.0The Limited In Vitro Lifetime Of Human Diploid Cell Strains. L HayflickExp Cell Res196514315085Yes
25986424321.00.00.0Parkinsonism: onset, progression and mortality. M M Hoehn, M D YahrNeurology19676067254Yes
26043194319.0171.05171.1Revisiting the behavioral model and access to medical care: does it matter? R M AndersenJ Health Soc Behav19957738325Yes
26143064306.0112.93112.9Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Y NishizukaScience19921411571No
26285944297.00.00.0Preparation of iodine-131 labelled human growth hormone of high specific activity. W M Hunter, F C GreenwoodNature196214450081Yes
263255714261.81005.53167.6Global cancer statistics. Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David FormanCA Cancer J Clin201121296855Yes
26442614261.0113.84113.8The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Y NishizukaNature19883045562No
26542604260.00.00.0The need for a new medical model: a challenge for biomedicine. G L EngelScience1977847460Yes
26642594259.0101.03101.0Cancer. p53, guardian of the genome. D P LaneNature19921614522No
26784814240.5249.15124.6The rise of graphene. A K Geim, K S NovoselovNat Mater200717330084Yes
26884764238.0231.23115.6A synaptic model of memory: long-term potentiation in the hippocampus. T V Bliss, G L CollingridgeNature19938421494No
26942334233.094.3794.4Apoptosis by death factor. S NagataCell19979039262No
27042244224.0113.19113.2Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. A H WyllieNature19806245367Yes
27142154215.0169.0169.0An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. Peter C AustinMultivariate Behav Res201121818162Yes
27242144214.00.00.0Amino acid metabolism in mammalian cell cultures. H EagleScience195913675766Yes
27342124212.094.8894.9Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. S HenikoffGene19846235151Yes
27442034203.00.00.0The genetical evolution of social behaviour. I. W D HamiltonJ Theor Biol19645875341Yes
27584024201.00.00.0Assessment of coma and impaired consciousness. A practical scale. G Teasdale, B JennettLancet19744136544Yes
27641934193.00.00.0Estimation of nuclear population from microtome sections. M AbercrombieAnat Rec194621015608Yes
27741904190.00.00.0A relation between non-esterified fatty acids in plasma and the metabolism of glucose. V P DoleJ Clin Invest195613286333Yes
278167384184.50.00.0A new and rapid colorimetric determination of acetylcholinesterase activity. G L Ellman, K D Courtney, V Andres, R M Feather-StoneBiochem Pharmacol196113726518Yes
27941804180.00.00.0The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. T NashBiochem J195313105648Yes
28083164158.0196.5998.3SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. N Guex, M C PeitschElectrophoresis19979504803Yes
28141454145.089.8789.9Alternative activation of macrophages. Siamon GordonNat Rev Immunol200312511873No
282248584143.01030.82171.8MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir KumarMol Biol Evol201121546353Yes
28341404140.099.4699.5Mechanisms of angiogenesis. W RisauNature19979109485No
28441334133.0124.52124.5How mitochondria produce reactive oxygen species. Michael P MurphyBiochem J200919061483No
28582544127.0179.4289.7Genomic sequencing. G M Church, W GilbertProc Natl Acad Sci U S A19846326095Yes
28641204120.087.587.5The retinoblastoma protein and cell cycle control. R A WeinbergCell19957736585No
28741104110.0125.66125.7Glutamate neurotoxicity and diseases of the nervous system. D W ChoiNeuron19882908446No
28841004100.087.387.3Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. C J MarshallCell19957834738No
28940864086.00.00.0The determination of enzyme inhibitor constants. M DixonBiochem J195313093635Yes
29040724072.00.00.0Determination of protein: a modification of the Lowry method that gives a linear photometric response. E F HartreeAnal Biochem19724115981Yes
29140704070.080.9180.9The phosphoinositide 3-kinase pathway. Lewis C CantleyScience200212040186No
29240454045.075.4375.4Generalized lacZ expression with the ROSA26 Cre reporter strain. P SorianoNat Genet19999916792Yes
29340134013.087.7987.8Wnt/beta-catenin signaling in development and disease. Hans CleversCell200617081971No
29440114011.00.00.0Bone: formation by autoinduction. M R UristScience19655319761Yes
29539913991.00.00.0Staining of tissue sections for electron microscopy with heavy metals. M L WatsonJ Biophys Biochem Cytol195813563554Yes
29639873987.0126.84126.8Bacterial evolution. C R WoeseMicrobiol Rev19872439888No
29739653965.00.00.0The detection of disease clustering and a generalized regression approach. N MantelCancer Res19676018555Yes
29879273963.50.00.0Functional Evaluation: The Barthel Index. F I Mahoney, D W BarthelMd State Med J196514258950Yes
29979233961.5224.81112.4Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. Florian Weigend, Reinhart AhlrichsPhys Chem Chem Phys200516240044Yes
30039603960.0103.7103.7Integrins: a family of cell surface receptors. R O HynesCell19873028640No
301118453948.3785.43261.8Cancer statistics, 2016. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201626742998Yes
30278863943.0188.0594.0MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Jürgen Cox, Matthias MannNat Biotechnol200819029910Yes
30378673933.5246.44123.2RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. Bo Li, Colin N DeweyBMC Bioinformatics201121816040Yes
30478643932.00.00.0Assessment of older people: self-maintaining and instrumental activities of daily living. M P Lawton, E M BrodyGerontologist19695349366Yes
30539273927.00.00.0Disc Electrophoresis. I. Background And Theory. L OrnsteinAnn N Y Acad Sci196414240533Yes
30678533926.50.00.0Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. H Aviv, P LederProc Natl Acad Sci U S A19724504350Yes
30739153915.0129.14129.1Tissue destruction by neutrophils. S J WeissN Engl J Med19892536474No
30838773877.0120.65120.7Nitric oxide as a secretory product of mammalian cells. C NathanFASEB J19921381691No
30938753875.0107.26107.3What is the evidence that tumors are angiogenesis dependent? J FolkmanJ Natl Cancer Inst19901688381No
31077413870.5190.595.2Collective dynamics of 'small-world' networks. D J Watts, S H StrogatzNature19989623998Yes
31138643864.087.887.8PAML: a program package for phylogenetic analysis by maximum likelihood. Z YangComput Appl Biosci19979367129Yes
31238583858.00.00.0Pharmacological implications of microsomal enzyme induction. A H ConneyPharmacol Rev19674383307Yes
31338503850.0134.55134.6Whatever happened to qualitative description? M SandelowskiRes Nurs Health200010940958No
31438453845.0143.64143.6EuroQol: the current state of play. R BrooksHealth Policy199610158943No
31538393839.00.00.0New methods for calculating metabolic rate with special reference to protein metabolism. J B De B WeirJ Physiol194915394301Yes
31638373837.086.286.2Atherosclerosis. A J LusisNature200011001066No
31738363836.0128.15128.2Updating P300: an integrative theory of P3a and P3b. John PolichClin Neurophysiol200717573239No
31838323832.088.7188.7Tandem repeats finder: a program to analyze DNA sequences. G BensonNucleic Acids Res19999862982Yes
31976633831.50.00.0Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. D E Paglia, W N ValentineJ Lab Clin Med19676066618Yes
32076473823.52079.591039.8Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. Zunyou Wu, Jennifer M McGooganJAMA202032091533Yes
32176193809.5224.97112.5Estimating F-Statistics For The Analysis Of Population Structure. B S Weir, C Clark CockerhamEvolution198428563791Yes
32237963796.082.0982.1The green fluorescent protein. R Y TsienAnnu Rev Biochem19989759496No
323113553785.00.00.0Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. W H Habig, M J Pabst, W B JakobyJ Biol Chem19744436300Yes
324113393779.7508.99169.7Development and validation of brief measures of positive and negative affect: the PANAS scales. D Watson, L A Clark, A TellegenJ Pers Soc Psychol19883397865Yes
325226683778.0758.39126.4Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C TurnerDiabetologia19853899825Yes
32637763776.080.8680.9A catalogue of splice junction sequences. S M MountNucleic Acids Res19827063411Yes
32737723772.0104.5104.5Revisions in the International System for Staging Lung Cancer. C F MountainChest19979187198Yes
32837593759.00.00.0Estimation of the molecular weights of proteins by Sephadex gel-filtration. P AndrewsBiochem J19644158310Yes
32937543754.00.00.0Preparation of isolated rat liver cells. P O SeglenMethods Cell Biol1976177845No
330150033750.8432.18108.0Features and development of Coot. P Emsley, B Lohkamp, W G Scott, K CowtanActa Crystallogr D Biol Crystallogr201020383002Yes
33174903745.0143.0371.5A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. R S Sikorski, P HieterGenetics19892659436Yes
33237443744.00.00.0A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. E PfeifferJ Am Geriatr Soc19751159263Yes
33374853742.5296.25148.1Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Kristopher J Preacher, Andrew F HayesBehav Res Methods200818697684Yes
33437373737.0108.35108.3Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. J H MorrisseyAnal Biochem19816172996Yes
33537373737.0100.92100.9Staphylococcus aureus infections. F D LowyN Engl J Med19989709046No
33637313731.093.5393.5Why most published research findings are false. John P A IoannidisPLoS Med200516060722Yes
337111613720.30.00.0Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. J F Kerr, A H Wyllie, A R CurrieBr J Cancer19724561027No
338111573719.0216.8372.3Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. J D Dignam, R M Lebovitz, R G RoederNucleic Acids Res19836828386Yes
33937063706.092.2892.3Multiple sequence alignment with hierarchical clustering. F CorpetNucleic Acids Res19882849754Yes
34037033703.00.00.0A membrane-filter technique for the detection of complementary DNA. D T DenhardtBiochem Biophys Res Commun19665963888Yes
34136813681.090.0290.0Caspases: the executioners of apoptosis. G M CohenBiochem J19979337844No
34236733673.00.00.0Evolution in Mendelian Populations. S WrightGenetics193117246615Yes
34373313665.5182.7891.4Mitochondria and apoptosis. D R Green, J C ReedScience19989721092No
34436623662.078.0878.1TGF-beta signal transduction. J MassaguéAnnu Rev Biochem19989759503No
34536593659.088.6888.7Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. A T BrüngerNature199218481394Yes
34636573657.00.00.0Principles that govern the folding of protein chains. C B AnfinsenScience19734124164Yes
347109173639.0827.32275.8Cancer Statistics, 2017. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201728055103Yes
348145523638.0397.2499.3Global cancer statistics, 2002. D Max Parkin, Freddie Bray, J Ferlay, Paola PisaniCA Cancer J Clin200515761078Yes
34972603630.0264.66132.3Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. U H Graneheim, B LundmanNurse Educ Today200414769454No
35072553627.5252.61126.3DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. P Librado, J RozasBioinformatics200919346325Yes
35136243624.075.2475.2Hypoxia--a key regulatory factor in tumour growth. Adrian L HarrisNat Rev Cancer200211902584No
35272383619.00.00.0The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. R C Graham, M J KarnovskyJ Histochem Cytochem19665962951Yes
35336033603.076.8276.8Protein secondary structure prediction based on position-specific scoring matrices. D T JonesJ Mol Biol199910493868Yes
35435993599.0109.55109.5Inositol trisphosphate and diacylglycerol as second messengers. M J BerridgeBiochem J19846146314No
35535883588.00.00.0Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. J CohenPsychol Bull196819673146Yes
35671753587.5206.71103.4Ab initio molecular dynamics for liquid metals. Kresse, HafnerPhys Rev B Condens Matter199310004490Yes
35735853585.0118.68118.7Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. Ilan H MeyerPsychol Bull200312956539No
35835843584.0137.69137.7Measuring the accuracy of diagnostic systems. J A SwetsScience19883287615No
35935813581.081.6781.7Protein production by auto-induction in high density shaking cultures. F William StudierProtein Expr Purif200515915565Yes
36071593579.50.00.0Radiological assessment of osteo-arthrosis. J H Kellgren, J S LawrenceAnn Rheum Dis195713498604Yes
36135723572.066.4866.5Somatic generation of antibody diversity. S TonegawaNature19836300689No
362107003566.71476.52492.2Cancer statistics, 2019. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201930620402Yes
36335663566.071.7771.8Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. G R MartinProc Natl Acad Sci U S A19816950406Yes
364106773559.0409.7136.6A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. J Ware, M Kosinski, S D KellerMed Care19968628042Yes
36535573557.083.683.6Novel proteinaceous infectious particles cause scrapie. S B PrusinerScience19826801762Yes
36635553555.0101.14101.1Sequencing technologies - the next generation. Michael L MetzkerNat Rev Genet201019997069No
36735503550.099.0899.1Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. R B D'AgostinoStat Med19989802183Yes
36835443544.0100.05100.0Biological roles of oligosaccharides: all of the theories are correct. A VarkiGlycobiology19938490246No
369106303543.31038.06346.0Cancer statistics, 2018. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201829313949Yes
37070823541.0183.4491.7tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. T M Lowe, S R EddyNucleic Acids Res19979023104Yes
37135413541.00.00.0The Scree Test For The Number Of Factors. R B CattellMultivariate Behav Res196626828106Yes
37235393539.0120.45120.5Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Russell A BarkleyPsychol Bull19979000892No
37335263526.0106.41106.4Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. VanderbiltPhys Rev B Condens Matter19909993096Yes
37435253525.082.2782.3Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Rakesh K JainScience200515637262No
37570483524.0301.24150.6The timed "Up & Go": a test of basic functional mobility for frail elderly persons. D Podsiadlo, S RichardsonJ Am Geriatr Soc19911991946Yes
37635013501.084.4284.4Marrow stromal cells as stem cells for nonhematopoietic tissues. D J ProckopScience19979082988No
37734953495.079.8479.8Instability and decay of the primary structure of DNA. T LindahlNature19938469282No
37869703485.0157.5778.8Functional rafts in cell membranes. K Simons, E IkonenNature19979177342No
37934853485.00.00.0Statistical estimations in enzyme kinetics. G N WilkinsonBiochem J196113785321Yes
38069653482.50.00.0A new method for sequencing DNA. A M Maxam, W GilbertProc Natl Acad Sci U S A1977265521Yes
38169643482.0131.966.0Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. A H Brand, N PerrimonDevelopment19938223268Yes
38269583479.0175.0587.5WGCNA: an R package for weighted correlation network analysis. Peter Langfelder, Steve HorvathBMC Bioinformatics200819114008Yes
383173603472.0505.35101.1Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. O P Hamill, A Marty, E Neher, B Sakmann, F J SigworthPflugers Arch19816270629Yes
38434673467.00.00.0Spectroscopic determination of tryptophan and tyrosine in proteins. H EdelhochBiochemistry19676049437Yes
38534603460.00.00.0Basic principles of ROC analysis. C E MetzSemin Nucl Med1978112681Yes
38634573457.00.00.0Generalized expectancies for internal versus external control of reinforcement. J B RotterPsychol Monogr19665340840No
38768833441.5164.6682.3"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. A P Feinberg, B VogelsteinAnal Biochem19846329026Yes
38868743437.0207.3103.7BEAST: Bayesian evolutionary analysis by sampling trees. Alexei J Drummond, Andrew RambautBMC Evol Biol200717996036Yes
38934273427.071.0771.1Mammalian neural stem cells. F H GageScience200010688783No
39068463423.0181.7790.9Control of goal-directed and stimulus-driven attention in the brain. Maurizio Corbetta, Gordon L ShulmanNat Rev Neurosci200211994752No
39168083404.0259.87129.9The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. I F Benzie, J J StrainAnal Biochem19968660627Yes
39234033403.077.6377.6Scaling and assessment of data quality. Philip EvansActa Crystallogr D Biol Crystallogr200616369096No
39333973397.00.00.0The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. J F WoessnerArch Biochem Biophys196113786180Yes
39433913391.0101.77101.8What's wrong with Bonferroni adjustments. T V PernegerBMJ19989553006No
39533843384.0117.88117.9How do you feel--now? The anterior insula and human awareness. A D Bud CraigNat Rev Neurosci200919096369No
396101333377.70.00.0The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. F C Greenwood, W M Hunter, J S GloverBiochem J196314097352Yes
39733753375.0115.3115.3genepop'007: a complete re-implementation of the genepop software for Windows and Linux. François RoussetMol Ecol Resour200821585727Yes
398134973374.2560.71140.2Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanAnn Intern Med200919622511No
39933683368.0103.19103.2Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. L R SquirePsychol Rev19921594723No
40033623362.084.2284.2The heat-shock response. S LindquistAnnu Rev Biochem19862427013No
40133613361.089.2889.3Microglia: a sensor for pathological events in the CNS. G W KreutzbergTrends Neurosci19968843599No
40233583358.0101.15101.2Protective and damaging effects of stress mediators. B S McEwenN Engl J Med19989428819No
403100663355.3451.47150.5Cancer statistics, 2013. Rebecca Siegel, Deepa Naishadham, Ahmedin JemalCA Cancer J Clin201323335087Yes
40433543354.00.00.0Observational study of behavior: sampling methods. J AltmannBehaviour19744597405No
40567053352.5174.3587.2TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. T R Mosmann, R L CoffmanAnnu Rev Immunol19892523712No
40633523352.079.5479.5The dendritic cell system and its role in immunogenicity. R M SteinmanAnnu Rev Immunol19911910679No
40733513351.0131.42131.4A concordance correlation coefficient to evaluate reproducibility. L I LinBiometrics19892720055Yes
40833433343.00.00.0Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. J D RowleyNature19734126434Yes
40933353335.065.5865.6Signal transduction by the JNK group of MAP kinases. R J DavisCell200011057897No
41033273327.069.0869.1Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. M KozakNucleic Acids Res19846694911Yes
41133193319.090.3890.4Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Kim A BrogdenNat Rev Microbiol200515703760No
41233153315.069.1969.2The scanning model for translation: an update. M KozakJ Cell Biol19892645293No
41333133313.00.00.0Equilibrium Ultracentrifugation Of Dilute Solutions. D A YphantisBiochemistry196414155091Yes
41433123312.092.6692.7Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. R W MahleyScience19883283935No
41533123312.087.3487.3Oxidative stress, antioxidants and stress tolerance. Ron MittlerTrends Plant Sci200212234732No
41666133306.5125.1362.6Translating the histone code. T Jenuwein, C D AllisScience200111498575No
41799193306.3409.83136.6A global measure of perceived stress. S Cohen, T Kamarck, R MermelsteinJ Health Soc Behav19836668417Yes
41833053305.084.9184.9Gene regulation by steroid hormones. M BeatoCell19892644044No
41933013301.089.3689.4The adolescent brain and age-related behavioral manifestations. L P SpearNeurosci Biobehav Rev200010817843No
42032973297.00.00.0Some factors in the interpretation of protein denaturation. W KauzmannAdv Protein Chem195914404936Yes
42198853295.0408.93136.3Cancer statistics, 2012. Rebecca Siegel, Deepa Naishadham, Ahmedin JemalCA Cancer J Clin201222237781Yes
42298583286.0326.03108.7Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. E R DeLong, D M DeLong, D L Clarke-PearsonBiometrics19883203132Yes
42332803280.0131.43131.4Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. O W GriffithAnal Biochem19807416462Yes
42465463273.00.00.0Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. D H Hubel, T N WieselJ Physiol196214449617Yes
42532723272.084.784.7Biologic basis for interleukin-1 in disease. C A DinarelloBlood19968630372No
426130563264.0306.2376.6Improved methods for building protein models in electron density maps and the location of errors in these models. T A Jones, J Y Zou, S W Cowan, M KjeldgaardActa Crystallogr A19912025413Yes
42732623262.00.00.0Estimation of average heterozygosity and genetic distance from a small number of individuals. M NeiGenetics197817248844Yes
42832573257.085.9185.9I-TASSER server for protein 3D structure prediction. Yang ZhangBMC Bioinformatics200818215316Yes
42932523252.077.8777.9Glutamate uptake. N C DanboltProg Neurobiol200111369436No
43032523252.077.8177.8Nonalcoholic fatty liver disease. Paul AnguloN Engl J Med200211961152No
43164883244.0169.2784.6An integrative theory of prefrontal cortex function. E K Miller, J D CohenAnnu Rev Neurosci200111283309No
43297293243.0550.19183.4Cancer statistics, 2015. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201525559415Yes
433129473236.8332.2983.1Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Ben Langmead, Cole Trapnell, Mihai Pop, Steven L SalzbergGenome Biol200919261174Yes
434194143235.71134.0189.0Global cancer statistics, 2012. Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin JemalCA Cancer J Clin201525651787Yes
43532333233.069.7769.8Profile hidden Markov models. S R EddyBioinformatics19989918945No
43632253225.088.1788.2Mesenchymal stem cells. A I CaplanJ Orthop Res19911870029Yes
43732193219.093.1593.2Inositol trisphosphate and diacylglycerol: two interacting second messengers. M J BerridgeAnnu Rev Biochem19873304132No
43832153215.0177.59177.6Executive functions. Adele DiamondAnnu Rev Psychol201323020641No
43932073207.087.0587.0The origins and the future of microfluidics. George M WhitesidesNature200616871203No
44063963198.00.00.0Microsomal lipid peroxidation. J A Buege, S D AustMethods Enzymol1978672633Yes
44131943194.0100.94100.9Graphene: status and prospects. A K GeimScience200919541989Yes
44231813181.074.5974.6Tolerance, danger, and the extended family. P MatzingerAnnu Rev Immunol19948011301No
44331773177.0105.56105.6Modeling valuations for EuroQol health states. P DolanMed Care19979366889Yes
44431733173.079.4879.5The transforming growth factor-beta family. J MassaguéAnnu Rev Cell Biol19902177343No
44531733173.074.7674.8Folding DNA to create nanoscale shapes and patterns. Paul W K RothemundNature200616541064Yes
44631623162.00.00.0The magical number seven plus or minus two: some limits on our capacity for processing information. G A MillerPsychol Rev195613310704Yes
44731583158.093.4893.5Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. Thomas WeltonChem Rev199911849019Yes
44831573157.085.5585.5ABC transporters: from microorganisms to man. C F HigginsAnnu Rev Cell Biol19921282354No
44931523152.00.00.0Diffusion-in-gel methods for immunological analysis. O OuchterlonyProg Allergy195813578996Yes
45031513151.070.7870.8Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. H F DvorakN Engl J Med19863537791No
45131383138.00.00.0Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. S W KesslerJ Immunol19751102604Yes
45262663133.0173.7486.9The basics of epithelial-mesenchymal transition. Raghu Kalluri, Robert A WeinbergJ Clin Invest200919487818No
45362653132.5186.8793.4Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Daniel R Zerbino, Ewan BirneyGenome Res200818349386Yes
454219013128.7510.0472.9UCSF Chimera--a visualization system for exploratory research and analysis. Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E FerrinJ Comput Chem200415264254Yes
45531273127.0101.45101.5Emerging adulthood. A theory of development from the late teens through the twenties. J J ArnettAm Psychol200010842426Yes
45631043104.064.6364.6CpG-rich islands and the function of DNA methylation. A P BirdNature19862423876No
45762003100.0122.7961.4The ubiquitin system. A Hershko, A CiechanoverAnnu Rev Biochem19989759494No
45861963098.0129.6464.8Statistical significance for genomewide studies. John D Storey, Robert TibshiraniProc Natl Acad Sci U S A200312883005Yes
45961953097.5236.37118.2Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Laurent Excoffier, Heidi E L LischerMol Ecol Resour201021565059Yes
46030973097.062.7462.7STATs and gene regulation. J E DarnellScience19979287210No
46130943094.059.0259.0Cell signaling by receptor tyrosine kinases. J SchlessingerCell200011057895No
46261853092.50.00.0Human malaria parasites in continuous culture. W Trager, J B JensenScience1976781840Yes
46330883088.068.5468.5Activators and target genes of Rel/NF-kappaB transcription factors. H L PahlOncogene199910602461No
46461583079.0137.4468.7Angiogenesis in cancer and other diseases. P Carmeliet, R K JainNature200011001068No
46530773077.076.076.0Neural networks and physical systems with emergent collective computational abilities. J J HopfieldProc Natl Acad Sci U S A19826953413Yes
46630743074.0100.31100.3Functions of DNA methylation: islands, start sites, gene bodies and beyond. Peter A JonesNat Rev Genet201222641018No
46730723072.073.2473.2WHAT IF: a molecular modeling and drug design program. G VriendJ Mol Graph19902268628Yes
46830633063.088.6788.7EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. W KlimeschBrain Res Brain Res Rev199910209231No
46961143057.0147.6573.8Inference of macromolecular assemblies from crystalline state. Evgeny Krissinel, Kim HenrickJ Mol Biol200717681537Yes
47091353045.0313.44104.5Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. R M Palmer, A G Ferrige, S MoncadaNature19873495737Yes
47130453045.075.4975.5Wound healing--aiming for perfect skin regeneration. P MartinScience19979082989No
47230453045.080.4280.4The pathobiology of diabetic complications: a unifying mechanism. Michael BrownleeDiabetes200515919781No
47330413041.075.1775.2Photoelectrochemical cells. M GrätzelNature200111713540Yes
47430253025.077.1177.1The basis of anisotropic water diffusion in the nervous system - a technical review. Christian BeaulieuNMR Biomed200212489094No
47530153015.084.1384.1Hay fever, hygiene, and household size. D P StrachanBMJ19892513902Yes
47630033003.070.8670.9Cadherin cell adhesion receptors as a morphogenetic regulator. M TakeichiScience19912006419No
47730013001.00.00.0A study of fixation for electron microscopy. G E PaladeJ Exp Med195214927794Yes
47859982999.0174.4387.2Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. S Duval, R TweedieBiometrics200010877304Yes
47929922992.075.1375.1Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Ting-Chao ChouPharmacol Rev200616968952No
48029892989.077.3677.4How do you feel? Interoception: the sense of the physiological condition of the body. A D CraigNat Rev Neurosci200212154366No
48129882988.00.00.0Towards a network theory of the immune system. N K JerneAnn Immunol (Paris)19744142565No
48289602986.7408.05136.0HTSeq--a Python framework to work with high-throughput sequencing data. Simon Anders, Paul Theodor Pyl, Wolfgang HuberBioinformatics201525260700Yes
48389252975.0236.8178.9Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Da Wei Huang, Brad T Sherman, Richard A LempickiNucleic Acids Res200919033363Yes
48429722972.00.00.0The gel-filtration behaviour of proteins related to their molecular weights over a wide range. P AndrewsBiochem J19655862401Yes
48529712971.00.00.0Gene action in the X-chromosome of the mouse (Mus musculus L.). M F LyonNature196113764598Yes
48659352967.5150.9275.5The plant immune system. Jonathan D G Jones, Jeffery L DanglNature200617108957No
48729662966.00.00.0A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. S HakomoriJ Biochem196414135466Yes
48829632963.00.00.0Transformed up-down methods in psychoacoustics. H LevittJ Acoust Soc Am19715541744Yes
48929632963.061.7761.8The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Isaiah J FidlerNat Rev Cancer200312778135No
49059172958.5125.8162.9Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. D B Smith, K S JohnsonGene19883047011Yes
49159142957.0227.31113.7Management of hepatocellular carcinoma: an update. Jordi Bruix, Morris ShermanHepatology201121374666No
49229542954.065.1565.2Mechanisms of angiogenesis and arteriogenesis. P CarmelietNat Med200010742145No
493177092951.5694.88115.8Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G CondeJ Biomed Inform200918929686Yes
49458762938.0142.2771.1Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. C Tuerk, L GoldScience19902200121Yes
49529332933.087.1587.2Drug combination studies and their synergy quantification using the Chou-Talalay method. Ting-Chao ChouCancer Res201020068163Yes
49629262926.091.7991.8Development of a classification system for periodontal diseases and conditions. G C ArmitageAnn Periodontol199910863370No
49729262926.00.00.0Catheter replacement of the needle in percutaneous arteriography; a new technique. S I SeldingerActa radiol195313057644Yes
49829242924.065.0965.1Angiogenesis in health and disease. Peter CarmelietNat Med200312778163No
49987642921.3337.52112.5Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Allison Tong, Peter Sainsbury, Jonathan CraigInt J Qual Health Care200717872937Yes
50029192919.091.3891.4Matrix metalloproteinases and their inhibitors in connective tissue remodeling. J F WoessnerFASEB J19911850705No
50129192919.062.8962.9Alzheimer's disease is a synaptic failure. Dennis J SelkoeScience200212399581No
502116692917.2472.45118.1Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanBMJ200919622551No
50387422914.0180.460.1Significance analysis of microarrays applied to the ionizing radiation response. V G Tusher, R Tibshirani, G ChuProc Natl Acad Sci U S A200111309499Yes
50429132913.063.9664.0Protein folding and misfolding. Christopher M DobsonNature200314685248No
50587322910.7243.7381.2Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Y Gavrieli, Y Sherman, S A Ben-SassonJ Cell Biol19921400587Yes
50658202910.0130.0465.0Toll-like receptor signalling. Shizuo Akira, Kiyoshi TakedaNat Rev Immunol200415229469No
50758142907.00.00.0Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. C Beauchamp, I FridovichAnal Biochem19714943714Yes
50829052905.069.7369.7Chemokines--chemotactic cytokines that mediate inflammation. A D LusterN Engl J Med19989459648No
50987062902.0191.363.8Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Benjamin P Lewis, Christopher B Burge, David P BartelCell200515652477Yes
51028942894.071.8271.8Phase separation of integral membrane proteins in Triton X-114 solution. C BordierJ Biol Chem19816257680Yes
51128932893.077.2977.3Origin and physiological roles of inflammation. Ruslan MedzhitovNature200818650913No
51228832883.094.3994.4An empirical correction for absorption anisotropy. R H BlessingActa Crystallogr A19957702794Yes
51328812881.0118.66118.7Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. T E MoffittPsychol Rev19938255953No
51428812881.094.3194.3Health promotion by social cognitive means. Albert BanduraHealth Educ Behav200415090118Yes
51528802880.0112.54112.5Half a century of research on the Stroop effect: an integrative review. C M MacLeodPsychol Bull19912034749No
51657562878.0135.7567.9MicroRNA signatures in human cancers. George A Calin, Carlo M CroceNat Rev Cancer200617060945No
51757492874.5163.881.9Inositol trisphosphate, a novel second messenger in cellular signal transduction. M J Berridge, R F IrvineNature19846095092No
51886202873.30.00.0The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. R J Havel, H A Eder, J H BragdonJ Clin Invest195513252080Yes
51928722872.051.7551.8One-step gene disruption in yeast. R J RothsteinMethods Enzymol19836310324Yes
52028682868.00.00.0Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. W C SchneiderJ Biol Chem194521005736Yes
52128632863.00.00.0Notes on sugar determination. M SmogyiJ Biol Chem195214938350Yes
52228622862.00.00.0Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. B E MurphyJ Clin Endocrinol Metab19674291524Yes
52328592859.00.00.0Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. L SvennerholmBiochim Biophys Acta195713436486Yes
52428582858.087.3687.4Non-coding RNAs in human disease. Manel EstellerNat Rev Genet201122094949No
52557062853.0104.5752.3The language of covalent histone modifications. B D Strahl, C D AllisNature200010638745Yes
526114112852.8454.0113.5APACHE II: a severity of disease classification system. W A Knaus, E A Draper, D P Wagner, J E ZimmermanCrit Care Med19853928249Yes
52785482849.30.00.0Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. G Fairbanks, T L Steck, D F WallachBiochemistry19714326772Yes
52856922846.00.00.0Pain mechanisms: a new theory. R Melzack, P D WallScience19655320816No
52956882844.00.00.0Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Glowinski, L L IversenJ Neurochem19665950056Yes
53028422842.055.0655.1RNA interference. Gregory J HannonNature200212110901No
53156692834.5165.1782.6Projections of global mortality and burden of disease from 2002 to 2030. Colin D Mathers, Dejan LoncarPLoS Med200617132052Yes
53228322832.069.5569.5Obesity as a medical problem. P G KopelmanNature200010766250No
53328292829.059.8859.9Principles of CDK regulation. D O MorganNature19957877684No
53456552827.5154.8777.4Fast and accurate long-read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics201020080505Yes
535112992824.8281.7770.4Haploview: analysis and visualization of LD and haplotype maps. J C Barrett, B Fry, J Maller, M J DalyBioinformatics200515297300Yes
53628232823.00.00.0A study of the adrenotropic receptors. R P AhlquistAm J Physiol194818882199Yes
53756422821.0148.0174.0Voxel-based morphometry--the methods. J Ashburner, K J FristonNeuroimage200010860804No
53856402820.00.00.0Assessment of outcome after severe brain damage. B Jennett, M BondLancet197546957Yes
53928192819.00.00.0A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. E A GehanBiometrika196514341275Yes
54056332816.50.00.0A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. S Reitman, S FrankelAm J Clin Pathol195713458125Yes
54128142814.093.1293.1Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Sarah E BarlowPediatrics200718055651Yes
54228112811.092.3292.3Hepatocellular carcinoma. Hashem B El-SeragN Engl J Med201121992124No
54328112811.0119.42119.4FreeSurfer. Bruce FischlNeuroimage201222248573No
54428102810.0129.93129.9The quality of care. How can it be assessed? A DonabedianJAMA19883045356No
545252472805.2700.3577.8The Sequence Alignment/Map format and SAMtools. Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard DurbinBioinformatics200919505943Yes
54628022802.061.9962.0Cardiac excitation-contraction coupling. Donald M BersNature200211805843No
54755952797.5153.8976.9The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. J Vieira, J MessingGene19826295879Yes
54827972797.094.3394.3Role of oxidative stress in development of complications in diabetes. J W BaynesDiabetes19912010041No
54955902795.00.00.0A method for determining the sedimentation behavior of enzymes: application to protein mixtures. R G Martin, B N AmesJ Biol Chem196113767412Yes
55027922792.00.00.0Measurement of pain. E C HuskissonLancet19744139420Yes
55155842792.00.00.0The fluid mosaic model of the structure of cell membranes. S J Singer, G L NicolsonScience19724333397Yes
55227902790.098.1898.2The processing-speed theory of adult age differences in cognition. T A SalthousePsychol Rev19968759042No
553111492787.20.00.0Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. P W Rigby, M Dieckmann, C Rhodes, P BergJ Mol Biol1977881736Yes
55455502775.00.00.0The serial cultivation of human diploid cell strains. L Hayflick, P S MoorheadExp Cell Res196113905658Yes
55555482774.0110.6355.3High-efficiency transformation of mammalian cells by plasmid DNA. C Chen, H OkayamaMol Cell Biol19873670292Yes
55627742774.00.00.0Efficient trace-labelling of proteins with iodine. A S McFARLANENature195813566175Yes
55727742774.066.5866.6Mitochondrial formation of reactive oxygen species. Julio F TurrensJ Physiol200314561818No
558138452769.0556.39111.3The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. D J Buysse, C F Reynolds, T H Monk, S R Berman, D J KupferPsychiatry Res19892748771Yes
55927692769.073.3573.3Recent advances with liposomes as pharmaceutical carriers. Vladimir P TorchilinNat Rev Drug Discov200515688077No
560110682767.0397.5199.4A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge KriegJ Chem Phys201020423165Yes
56155272763.5134.0267.0Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. T C Chou, P TalalayAdv Enzyme Regul19846382953Yes
56227622762.084.5184.5Implications of normal brain development for the pathogenesis of schizophrenia. D R WeinbergerArch Gen Psychiatry19873606332Yes
56382692756.3179.6259.9Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. C M Gorman, L F Moffat, B H HowardMol Cell Biol19826960240Yes
56427562756.089.1289.1Psychometric properties of the strengths and difficulties questionnaire. R GoodmanJ Am Acad Child Adolesc Psychiatry200111699809Yes
56555072753.5244.88122.4Revised methods for the Salmonella mutagenicity test. D M Maron, B N AmesMutat Res19836341825Yes
56627532753.057.257.2Toll-like receptors and innate immunity. R MedzhitovNat Rev Immunol200111905821No
56754842742.0128.3364.2Caspases: enemies within. N A Thornberry, Y LazebnikScience19989721091No
56882172739.0224.7574.9Understanding the Warburg effect: the metabolic requirements of cell proliferation. Matthew G Vander Heiden, Lewis C Cantley, Craig B ThompsonScience200919460998No
56927382738.071.8771.9Optimal two-stage designs for phase II clinical trials. R SimonControl Clin Trials19892702835Yes
57027362736.061.2661.3Inflammatory bowel disease. Daniel K PodolskyN Engl J Med200212167685No
57127322732.00.00.0Stereotaxic mapping of the monoamine pathways in the rat brain. U UngerstedtActa Physiol Scand Suppl19714109331Yes
57254582729.0135.5867.8In vitro selection of RNA molecules that bind specific ligands. A D Ellington, J W SzostakNature19901697402Yes
57327272727.053.1853.2Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. P SchuckBiophys J200010692345Yes
57454462723.0176.8188.4Tissue engineering. R Langer, J P VacantiScience19938493529No
57527222722.066.6866.7Cell death during development of the nervous system. R W OppenheimAnnu Rev Neurosci19912031577No
57627212721.078.0978.1Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. Y X FuGenetics19979335623Yes
57727192719.065.3565.3Structure and function of telomeres. E H BlackburnNature19911708110No
57854292714.5185.5692.8Measuring agreement in method comparison studies. J M Bland, D G AltmanStat Methods Med Res199910501650No
57981422714.0206.3268.8TopHat: discovering splice junctions with RNA-Seq. Cole Trapnell, Lior Pachter, Steven L SalzbergBioinformatics200919289445Yes
580108512712.8369.0192.3Cancer statistics, 2010. Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth WardCA Cancer J Clin201020610543Yes
58127112711.0126.78126.8The short-form McGill Pain Questionnaire. Ronald MelzackPain19873670870Yes
58227112711.052.5152.5Genome maintenance mechanisms for preventing cancer. J H HoeijmakersNature200111357144No
58354082704.0126.763.4Oncomirs - microRNAs with a role in cancer. Aurora Esquela-Kerscher, Frank J SlackNat Rev Cancer200616557279No
58427032703.00.00.0Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. P MitchellNature196113771349Yes
58527022702.064.2964.3Molecular chaperones in cellular protein folding. F U HartlNature19968637592No
58680892696.3210.6770.2MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Sudhir Kumar, Koichiro Tamura, Masatoshi NeiBrief Bioinform200415260895Yes
58753822691.0125.6662.8Oxidants, oxidative stress and the biology of ageing. T Finkel, N J HolbrookNature200011089981No
58853782689.0128.4964.2Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. F W Studier, B A MoffattJ Mol Biol19863537305Yes
58953782689.00.00.0A modified uronic acid carbazole reaction. T Bitter, H M MuirAnal Biochem196213971270Yes
59026852685.00.00.0Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. P CuatrecasasJ Biol Chem19705432796Yes
59126812681.062.6662.7TGFbeta in Cancer. Joan MassaguéCell200818662538No
59226762676.091.5391.5Essential oils: their antibacterial properties and potential applications in foods--a review. Sara BurtInt J Food Microbiol200415246235No
59326712671.00.00.0A gene complex controlling segmentation in Drosophila. E B LewisNature1978103000Yes
59426632663.082.4782.5Primate models of movement disorders of basal ganglia origin. M R DeLongTrends Neurosci19901695404No
59553252662.5132.8566.4Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. D Hanahan, J FolkmanCell19968756718No
59653242662.0500.81250.4A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. Terry K Koo, Mae Y LiJ Chiropr Med201627330520Yes
59726612661.087.1487.1No adjustments are needed for multiple comparisons. K J RothmanEpidemiology19902081237Yes
59826582658.00.00.0A simple technique for demonstrating centromeric heterochromatin. A T SumnerExp Cell Res19724117921Yes
59926582658.083.283.2Estimation of metabolite concentrations from localized in vivo proton NMR spectra. S W ProvencherMagn Reson Med19938139448Yes
60026582658.00.00.0The genetical structure of populations. S WrightAnn Eugen195124540312Yes
60179712657.0267.089.0Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. R A Deyo, D C Cherkin, M A CiolJ Clin Epidemiol19921607900Yes
60253072653.5165.5782.8Glutathione. A Meister, M E AndersonAnnu Rev Biochem19836137189No
60379232641.02008.72669.6Cancer statistics, 2020. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin202031912902Yes
60426372637.049.1849.2Wnt signaling and cancer. P PolakisGenes Dev200010921899No
60526292629.059.9760.0Nuclear factor-kappaB in cancer development and progression. Michael KarinNature200616724054No
60652512625.5182.391.2The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Stephen B Edge, Carolyn C ComptonAnn Surg Oncol201020180029No
60726252625.00.00.0Analysis of gene diversity in subdivided populations. M NeiProc Natl Acad Sci U S A19734519626Yes
60852432621.5176.6488.3mTOR signaling in growth control and disease. Mathieu Laplante, David M SabatiniCell201222500797No
60952422621.0114.7557.4Emergence of scaling in random networks Barabasi, AlbertScience199910521342Yes
610104782619.5229.9857.5Cluster analysis and display of genome-wide expression patterns. M B Eisen, P T Spellman, P O Brown, D BotsteinProc Natl Acad Sci U S A19989843981Yes
61152392619.50.00.0Some quantitative uses of drug antagonists. O Arunlakshana, H O SchildBr J Pharmacol Chemother195913651579Yes
61226182618.054.7954.8Papillomaviruses and cancer: from basic studies to clinical application. Harald zur HausenNat Rev Cancer200212044010No
61352302615.0107.9754.0Establishment in culture of pluripotential cells from mouse embryos. M J Evans, M H KaufmanNature19817242681Yes
61452282614.0188.1794.1A method of comparing the areas under receiver operating characteristic curves derived from the same cases. J A Hanley, B J McNeilRadiology19836878708Yes
61526102610.068.0868.1The resurgence of platinum-based cancer chemotherapy. Lloyd KellandNat Rev Cancer200717625587No
61626092609.046.2346.2Mechanisms underlying ubiquitination. C M PickartAnnu Rev Biochem200111395416No
61752082604.0153.4676.7The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Taro Kawai, Shizuo AkiraNat Immunol201020404851No
61852062603.0163.5781.8Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. K Tamura, M NeiMol Biol Evol19938336541Yes
61926012601.053.9754.0Interleukin-12 and the regulation of innate resistance and adaptive immunity. Giorgio TrinchieriNat Rev Immunol200312563297No
62051992599.5183.6591.8A simple, rapid, and sensitive DNA assay procedure. C Labarca, K PaigenAnal Biochem19806158890Yes
62151912595.5191.5395.8Longitudinal data analysis for discrete and continuous outcomes. S L Zeger, K Y LiangBiometrics19863719049Yes
62225952595.083.0383.0Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. B SamuelssonScience19836301011Yes
62325932593.059.8959.9Cell adhesion: the molecular basis of tissue architecture and morphogenesis. B M GumbinerCell19968608588No
62425932593.060.4560.5Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. S A BustinJ Mol Endocrinol200011013345No
62525892589.053.2153.2The danger model: a renewed sense of self. Polly MatzingerScience200211951032Yes
62651782589.0137.0368.5Exploring the full spectrum of macrophage activation. David M Mosser, Justin P EdwardsNat Rev Immunol200819029990No
62725872587.00.00.0The membrane actions of anesthetics and tranquilizers. P SeemanPharmacol Rev19724565956No
62851722586.0117.0658.5Signal transduction by receptors with tyrosine kinase activity. A Ullrich, J SchlessingerCell19902158859No
62925862586.0120.85120.8Detecting alcoholism. The CAGE questionnaire. J A EwingJAMA19846471323Yes
63077502583.3179.2259.7The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. R C Lee, R L Feinbaum, V AmbrosCell19938252621Yes
63125802580.052.5252.5Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Shimon SakaguchiAnnu Rev Immunol200415032588No
63225802580.098.3298.3You want to measure coping but your protocol's too long: consider the brief COPE. C S CarverInt J Behav Med199716250744Yes
63325752575.064.7764.8The nerve growth factor 35 years later. R Levi-MontalciniScience19873306916No
63425732573.00.00.0The biology of oxygen radicals. I FridovichScience1978210504Yes
63551412570.50.00.0Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. L A Greene, A S TischlerProc Natl Acad Sci U S A19761065897Yes
63625642564.00.00.0The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. R R PorterBiochem J195914434282Yes
63751172558.5106.4453.2Innate immune recognition. Charles A Janeway, Ruslan MedzhitovAnnu Rev Immunol200211861602No
63825582558.00.00.0Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. O SmithiesBiochem J195513276348Yes
639204612557.6462.1757.8The Protein Data Bank. H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E BourneNucleic Acids Res200010592235Yes
64025572557.00.00.0Elastic properties of lipid bilayers: theory and possible experiments. W HelfrichZ Naturforsch C19734273690Yes
64151142557.00.00.0Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. J Sedlak, R H LindsayAnal Biochem19684973948Yes
64225572557.055.6955.7G1 phase progression: cycling on cue. C J SherrCell19947954821No
64376562552.0229.176.4Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. G Evanno, S Regnaut, J GoudetMol Ecol200515969739Yes
64425512551.062.7862.8Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. E C ButcherCell19911760836No
64551002550.0173.4586.7Computed tomography--an increasing source of radiation exposure. David J Brenner, Eric J HallN Engl J Med200718046031No
64625492549.081.0981.1What are the functional consequences of neurocognitive deficits in schizophrenia? M F GreenAm J Psychiatry19968610818No
64725432543.073.0873.1Delayed neuronal death in the gerbil hippocampus following ischemia. T KirinoBrain Res19827093691Yes
64825362536.075.3575.3RELION: implementation of a Bayesian approach to cryo-EM structure determination. Sjors H W ScheresJ Struct Biol201223000701Yes
64925342534.067.867.8Predictive reward signal of dopamine neurons. W SchultzJ Neurophysiol19989658025No
65025332533.0132.86132.9Interrater reliability: the kappa statistic. Mary L McHughBiochem Med (Zagreb)201223092060Yes
65125302530.00.00.0On the number of segregating sites in genetical models without recombination. G A WattersonTheor Popul Biol19751145509Yes
65250602530.00.00.0The Social Readjustment Rating Scale. T H Holmes, R H RaheJ Psychosom Res19676059863Yes
65325292529.060.8260.8Memory--a century of consolidation. J L McGaughScience200010634773No
65425282528.070.1370.1Cellular and molecular mechanisms of fibrosis. T A WynnJ Pathol200818161745No
65550532526.5161.7980.9Complex brain networks: graph theoretical analysis of structural and functional systems. Ed Bullmore, Olaf SpornsNat Rev Neurosci200919190637No
65625192519.096.0596.0Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. Joseph P WeirJ Strength Cond Res200515705040No
65750302515.0158.5979.3The L-arginine-nitric oxide pathway. S Moncada, A HiggsN Engl J Med19937504210No
65850292514.5110.9755.5Inflammation and cancer: back to Virchow? F Balkwill, A MantovaniLancet200111229684No
65925132513.00.00.0Models for the specific adhesion of cells to cells. G I BellScience1978347575No
66025112511.077.6577.7Secretory products of macrophages. C F NathanJ Clin Invest19873543052No
66150192509.5223.29111.6The qualitative content analysis process. Satu Elo, Helvi KyngäsJ Adv Nurs200818352969Yes
66225032503.050.8650.9Universal control mechanism regulating onset of M-phase. P NurseNature19902138713No
66325022502.00.00.0The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. M L AnsonJ Gen Physiol193819873094Yes
66450032501.50.00.0Electrochemical photolysis of water at a semiconductor electrode. A Fujishima, K HondaNature197212635268Yes
66525012501.058.7958.8Prostaglandins and leukotrienes: advances in eicosanoid biology. C D FunkScience200111729303No
66649972498.50.00.0A diagnostic interview: the schedule for affective disorders and schizophrenia. J Endicott, R L SpitzerArch Gen Psychiatry1978678037Yes
66724972497.090.9290.9Measures of reliability in sports medicine and science. W G HopkinsSports Med200010907753Yes
66849872493.50.00.0Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. P J Fraker, J C SpeckBiochem Biophys Res Commun1978637870Yes
66924902490.059.9159.9Autophagy: process and function. Noboru MizushimaGenes Dev200718006683No
67099282482.0306.0176.5Establishing a standard definition for child overweight and obesity worldwide: international survey. T J Cole, M C Bellizzi, K M Flegal, W H DietzBMJ200010797032Yes
67124812481.00.00.0The catecholamine hypothesis of affective disorders: a review of supporting evidence. J J SchildkrautAm J Psychiatry19655319766No
67249612480.5147.2373.6Adherence to medication. Lars Osterberg, Terrence BlaschkeN Engl J Med200516079372No
67324782478.00.00.0The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. S BoydenJ Exp Med196213872176Yes
67424772477.00.00.0Oxygen-dependent microbial killing by phagocytes (first of two parts). B M BabiorN Engl J Med197824176Yes
67524672467.00.00.0Perceived exertion as an indicator of somatic stress. G BorgScand J Rehabil Med19705523831Yes
67649242462.0200.49100.2A feature-integration theory of attention. A M Treisman, G GeladeCogn Psychol19807351125Yes
67724612461.081.6581.7Accelerated Profile HMM Searches. Sean R EddyPLoS Comput Biol201122039361Yes
67824602460.064.6864.7The genetic legacy of the Quaternary ice ages. G HewittNature200010879524No
67924592459.055.2955.3Bone resorption by osteoclasts. S L TeitelbaumScience200010968780No
68024552455.00.00.0Colorimetric assay of catalase. A K SinhaAnal Biochem19724556490Yes
68149102455.0137.5668.8Unified segmentation. John Ashburner, Karl J FristonNeuroimage200515955494Yes
68273572452.3180.0260.0Pathogen recognition and innate immunity. Shizuo Akira, Satoshi Uematsu, Osamu TakeuchiCell200616497588No
68324522452.00.00.0Satellite cell of skeletal muscle fibers. A MauroJ Biophys Biochem Cytol196113768451Yes
68473462448.7405.89135.3Deep learning. Yann LeCun, Yoshua Bengio, Geoffrey HintonNature201526017442No
68524402440.066.2966.3Dominant forces in protein folding. K A DillBiochemistry19902207096No
68624382438.091.8291.8What is value in health care? Michael E PorterN Engl J Med201021142528Yes
68724362436.055.2755.3Social controls on cell survival and cell death. M C RaffNature19921557121No
68848672433.5169.9785.0Complex network measures of brain connectivity: uses and interpretations. Mikail Rubinov, Olaf SpornsNeuroimage201019819337Yes
68924302430.0137.01137.0Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Daniël LakensFront Psychol201324324449No
69048592429.50.00.0Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. S Marklund, G MarklundEur J Biochem19744215654Yes
69124272427.071.5671.6Formation and Structure of Self-Assembled Monolayers. Abraham UlmanChem Rev199611848802Yes
69248402420.0157.1178.6Accurate and simple analytic representation of the electron-gas correlation energy. Perdew, WangPhys Rev B Condens Matter199210001404Yes
69324202420.058.2558.2Vascular endothelial growth factor: basic science and clinical progress. Napoleone FerraraEndocr Rev200415294883No
69448382419.0238.15119.1phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. Paul J McMurdie, Susan HolmesPLoS One201323630581Yes
69548282414.0183.9892.0FLASH: fast length adjustment of short reads to improve genome assemblies. Tanja Magoč, Steven L SalzbergBioinformatics201121903629Yes
69624122412.098.0298.0The Danish Civil Registration System. Carsten Bøcker PedersenScand J Public Health201121775345Yes
69748222411.0159.6479.8The neural basis of drug craving: an incentive-sensitization theory of addiction. T E Robinson, K C BerridgeBrain Res Brain Res Rev19938401595No
69848212410.5117.4558.7Calculation of protein extinction coefficients from amino acid sequence data. S C Gill, P H von HippelAnal Biochem19892610349Yes
69948202410.00.00.0Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. J V Durnin, J WomersleyBr J Nutr19744843734Yes
70024072407.00.00.0Transduction of linked genetic characters of the host by bacteriophage P1. E S LennoxVirology195513267987Yes
70148122406.0121.160.5Autophagy in the pathogenesis of disease. Beth Levine, Guido KroemerCell200818191218No
70224042404.055.5155.5Salt and drought stress signal transduction in plants. Jian-Kang ZhuAnnu Rev Plant Biol200212221975No
70324032403.077.6477.6adegenet: a R package for the multivariate analysis of genetic markers. Thibaut JombartBioinformatics200818397895Yes
70447982399.0237.42118.7GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. Rod Peakall, Peter E SmouseBioinformatics201222820204Yes
70547912395.5123.9862.0Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Weizhong Li, Adam GodzikBioinformatics200616731699Yes
70623952395.057.5457.5Epigenetics in cancer. Manel EstellerN Engl J Med200818337604No
70747882394.098.0249.0Untangling the ErbB signalling network. Y Yarden, M X SliwkowskiNat Rev Mol Cell Biol200111252954No
70823922392.065.6665.7Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. H G GratznerScience19827123245Yes
70995632390.8473.5118.4Cancer statistics, 2014. Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin JemalCA Cancer J Clin201424399786Yes
71023902390.057.257.2Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. G P SmithScience19854001944Yes
71123822382.00.00.0The glomerular permeability determined by dextran clearance using Sephadex gel filtration. C E MogensenScand J Clin Lab Invest19685637478Yes
71247642382.095.1547.6CDK inhibitors: positive and negative regulators of G1-phase progression. C J Sherr, J M RobertsGenes Dev199910385618No
71371432381.0141.9247.3Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Ron Edgar, Michael Domrachev, Alex E LashNucleic Acids Res200211752295Yes
71447612380.50.00.0Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. J D Watson, F H CrickNature195313054692Yes
71523792379.00.00.0Electroimmuno assay. C B LaurellScand J Clin Lab Invest Suppl19724114358Yes
71647582379.00.00.0A general method applicable to the search for similarities in the amino acid sequence of two proteins. S B Needleman, C D WunschJ Mol Biol19705420325Yes
71723792379.061.361.3Cancer nanotechnology: opportunities and challenges. Mauro FerrariNat Rev Cancer200515738981No
71847562378.0102.2151.1MicroRNAs: small RNAs with a big role in gene regulation. Lin He, Gregory J HannonNat Rev Genet200415211354No
71923702370.046.5646.6Getting started with yeast. F ShermanMethods Enzymol19912005794Yes
72023662366.00.00.0A rapid radiochemical method for the determination of choline acetyltransferase. F FonnumJ Neurochem19751113118Yes
72123602360.054.5154.5Angiogenesis in life, disease and medicine. Peter CarmelietNature200516355210No
72223512351.057.457.4Calcium signaling. David E ClaphamCell200718083096No
72346982349.00.00.0Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. J Silness, H LoeActa Odontol Scand196414158464Yes
72423482348.070.5570.5A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. Heng LiBioinformatics201121903627Yes
72546952347.50.00.0Screening lambdagt recombinant clones by hybridization to single plaques in situ. W D Benton, R W DavisScience1977322279Yes
72623442344.057.7657.8MapChart: software for the graphical presentation of linkage maps and QTLs. R E VoorripsJ Hered200212011185Yes
72723402340.051.151.1Evolving concepts of rheumatoid arthritis. Gary S FiresteinNature200312748655No
72823292329.097.4497.4Qualitative research. Introducing focus groups. J KitzingerBMJ19957633241Yes
72923282328.051.5451.5Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. T HunterCell19957834742No
73023272327.063.3863.4The magical number 4 in short-term memory: a reconsideration of mental storage capacity. N CowanBehav Brain Sci200111515286Yes
73146522326.00.00.0Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. R A Laskey, A D MillsEur J Biochem19751175627Yes
73223202320.085.9886.0Calmodulin plays a pivotal role in cellular regulation. W Y CheungScience19806243188No
73323172317.067.4667.5Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. P CorreaCancer Res19921458460No
73423162316.048.0648.1Tumour-educated macrophages promote tumour progression and metastasis. Jeffrey W PollardNat Rev Cancer200414708027No
73523142314.053.7853.8A decade of molecular biology of retinoic acid receptors. P ChambonFASEB J19968801176No
73623132313.00.00.0The Michigan alcoholism screening test: the quest for a new diagnostic instrument. M L SelzerAm J Psychiatry19715565851Yes
73723122312.00.00.0Application of a microtechnique to viral serological investigations. J L SeverJ Immunol196213910995Yes
73846202310.0144.9572.5Rapid isolation of high molecular weight plant DNA. M G Murray, W F ThompsonNucleic Acids Res19807433111Yes
73969292309.7379.05126.4Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. P J Van Soest, J B Robertson, B A LewisJ Dairy Sci19911660498No
74023042304.052.1152.1The structure and regulation of protein phosphatases. P CohenAnnu Rev Biochem19892549856No
74146042302.0104.5552.3Death receptors: signaling and modulation. A Ashkenazi, V M DixitScience19989721089No
74222982298.00.00.0Separation of leukocytes from blood and bone marrow. Introduction. A BöyumScand J Clin Lab Invest Suppl19685707208Yes
74322962296.00.00.0Inositol phospholipids and cell surface receptor function. R H MichellBiochim Biophys Acta1975164246No
74445892294.595.2147.6Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. D Bonnet, J E DickNat Med19979212098Yes
74522942294.066.4966.5Interleukin-1 and interleukin-1 antagonism. C A DinarelloBlood19911826616No
74622932293.057.6357.6Bcl-2 and the regulation of programmed cell death. J C ReedJ Cell Biol19948294493No
74722882288.00.00.0Muscle structure and theories of contraction. A F HuxleyProg Biophys Biophys Chem195713485191Yes
74845662283.00.00.0High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. M N Berry, D S FriendJ Cell Biol19694900611Yes
74922822282.072.0972.1SF-36 health survey update. J E WareSpine (Phila Pa 1976)200011124729No
75022822282.073.9874.0Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Peter C AustinStat Med200919757444Yes
75145612280.591.9646.0The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Igor Vivanco, Charles L SawyersNat Rev Cancer200212094235No
75245552277.5131.7765.9Pattern recognition receptors and inflammation. Osamu Takeuchi, Shizuo AkiraCell201020303872No
75322752275.00.00.0Stereochemistry of cooperative effects in haemoglobin. M F PerutzNature19705528785Yes
75422722272.067.7467.7Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. M LeavittMedGenMed200111549951No
75522722272.00.00.0A Rationale And Test For The Number Of Factors In Factor Analysis. J L HornPsychometrika196514306381Yes
75622712271.00.00.0Evaluating the quality of medical care. A DonabedianMilbank Mem Fund Q19665338568No
75722702270.045.845.8SV40-transformed simian cells support the replication of early SV40 mutants. Y GluzmanCell19816260373Yes
75868072269.00.00.0On The Nature Of Allosteric Transitions: A Plausible Model. J Monod, J Wyman, J P ChangeuxJ Mol Biol196514343300Yes
75945342267.092.4346.2Lipid rafts and signal transduction. K Simons, D ToomreNat Rev Mol Cell Biol200011413487No
76090672266.8290.6472.7Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Qiong Wang, George M Garrity, James M Tiedje, James R ColeAppl Environ Microbiol200717586664Yes
76122632263.051.7951.8Mitochondrial diseases in man and mouse. D C WallaceScience199910066162No
76245252262.5123.1261.6Management of hepatocellular carcinoma. Jordi Bruix, Morris ShermanHepatology200516250051No
76322602260.076.5176.5Glutamate, nitric oxide and cell-cell signalling in the nervous system. J GarthwaiteTrends Neurosci19911708538No
76422582258.057.7157.7Molecular basis of bacterial outer membrane permeability revisited. Hiroshi NikaidoMicrobiol Mol Biol Rev200314665678No
76522582258.058.5658.6Causes and consequences of microRNA dysregulation in cancer. Carlo M CroceNat Rev Genet200919763153No
76622542254.081.3281.3A computational approach to edge detection. J CannyIEEE Trans Pattern Anal Mach Intell198621869365Yes
76745062253.0225.25112.6Stress, social support, and the buffering hypothesis. S Cohen, T A WillsPsychol Bull19853901065No
76845032251.586.0943.0A novel genetic system to detect protein-protein interactions. S Fields, O SongNature19892547163Yes
76922502250.056.7856.8A model for receptor-regulated calcium entry. J W PutneyCell Calcium19862420465No
77022502250.060.060.0Dietary pattern analysis: a new direction in nutritional epidemiology. Frank B HuCurr Opin Lipidol200211790957No
77122482248.00.00.0The information capacity of the human motor system in controlling the amplitude of movement. P M FittsJ Exp Psychol195413174710Yes
77244942247.0103.6751.8A simple and very efficient method for generating cDNA libraries. U Gubler, B J HoffmanGene19836198242Yes
77322432243.055.9856.0Modularity and community structure in networks. M E J NewmanProc Natl Acad Sci U S A200616723398Yes
77422422242.049.3849.4Molecular physiology of P2X receptors. R Alan NorthPhysiol Rev200212270951No
77522382238.059.5959.6A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. P ChomczynskiBiotechniques19937692896Yes
77622352235.081.1981.2DNA methylation age of human tissues and cell types. Steve HorvathGenome Biol201324138928Yes
77722342234.071.4371.4Reactive oxygen species and the central nervous system. B HalliwellJ Neurochem19921402908No
77822272227.055.3455.3Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J Kyhse-AndersenJ Biochem Biophys Methods19846530509Yes
779133582226.3323.1453.9Phaser crystallographic software. Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J ReadJ Appl Crystallogr200719461840Yes
78022232223.050.0650.1Chemokines and leukocyte traffic. M BaggioliniNature19989560152No
78144422221.099.9650.0Organization and expression of eucaryotic split genes coding for proteins. R Breathnach, P ChambonAnnu Rev Biochem19816791577No
78222212221.053.2753.3Mechanisms and genes of cellular suicide. H StellerScience19957878463No
78344412220.5119.6359.8Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Marie-Christine Daniel, Didier AstrucChem Rev200414719978No
78422202220.00.00.0Mechanisms of action of transmitters and other substances on smooth muscle. T B BoltonPhysiol Rev197937533No
78544402220.00.00.0On the size of the active site in proteases. I. Papain. I Schechter, A BergerBiochem Biophys Res Commun19676035483Yes
78622182218.066.0266.0Two-sided confidence intervals for the single proportion: comparison of seven methods. R G NewcombeStat Med19989595616Yes
78722172217.047.9548.0Telomere measurement by quantitative PCR. Richard M CawthonNucleic Acids Res200212000852Yes
78844312215.50.00.0The interpretation of protein structures: estimation of static accessibility. B Lee, F M RichardsJ Mol Biol19715551392Yes
78922152215.061.9461.9Molecular diversity of glutamate receptors and implications for brain function. S NakanishiScience19921329206No
79044292214.50.00.0Periodontal Disease In Pregnancy. I. Prevalence And Severity. H Loe, J SilnessActa Odontol Scand196314121956Yes
79144282214.0156.378.2The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. S H Downs, N BlackJ Epidemiol Community Health19989764259Yes
79244242212.096.4348.2New functions for the matrix metalloproteinases in cancer progression. Mikala Egeblad, Zena WerbNat Rev Cancer200211990853No
79322112211.055.355.3The anatomy and taxonomy of protein structure. J S RichardsonAdv Protein Chem19817020376No
79422112211.053.3953.4Protein kinase C and lipid signaling for sustained cellular responses. Y NishizukaFASEB J19957737456No
79544202210.0116.3458.2A receptor-mediated pathway for cholesterol homeostasis. M S Brown, J L GoldsteinScience19863513311No
79622102210.078.1878.2Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. B N AmesScience19836351251No
79722092209.00.00.0[Rapid physiological coagulation method in determination of fibrinogen]. A ClaussActa Haematol195713434757Yes
79822082208.085.5985.6Role of endothelium in responses of vascular smooth muscle. R F FurchgottCirc Res19836313250No
79966192206.3300.06100.0Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. J L Cox, J M Holden, R SagovskyBr J Psychiatry19873651732Yes
80022052205.00.00.0Removal of fatty acids from serum albumin by charcoal treatment. R F ChenJ Biol Chem19676016603Yes
80144052202.5149.474.7Random-effects models for longitudinal data. N M Laird, J H WareBiometrics19827168798Yes
80222002200.068.5668.6Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. R A DeFronzoDiabetes19883289989No
80321992199.054.2354.2Ischemic cell death in brain neurons. P LiptonPhysiol Rev199910508238No
80421992199.042.542.5Java Treeview--extensible visualization of microarray data. Alok J SaldanhaBioinformatics200415180930Yes
80543862193.00.00.0The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J A Spudich, S WattJ Biol Chem19714254541Yes
80643862193.00.00.0A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. J E TILL, E A McCULLOCHRadiat Res196113776896Yes
80721872187.065.2965.3Physiology and neurobiology of stress and adaptation: central role of the brain. Bruce S McEwenPhysiol Rev200717615391No
80843672183.5133.0466.5Neural mechanisms of selective visual attention. R Desimone, J DuncanAnnu Rev Neurosci19957605061No
80921832183.068.2368.2Prooxidant states and tumor promotion. P A CeruttiScience19852981433No
81065442181.3152.0650.7The biology of VEGF and its receptors. Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouterNat Med200312778165No
81143512175.5128.8364.4Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. C J Murray, A D LopezLancet19979167458Yes
81221752175.086.8186.8Effective physician-patient communication and health outcomes: a review. M A StewartCMAJ19957728691Yes
81321712171.048.5248.5The regulation of AP-1 activity by mitogen-activated protein kinases. M KarinJ Biol Chem19957622446No
81465092169.7192.7864.3Bacterial biofilms: a common cause of persistent infections. J W Costerton, P S Stewart, E P GreenbergScience199910334980No
81543382169.0103.4951.7Signal integration in the endoplasmic reticulum unfolded protein response. David Ron, Peter WalterNat Rev Mol Cell Biol200717565364No
81621662166.049.9249.9A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Douglas C WallaceAnnu Rev Genet200516285865No
81721652165.041.6841.7Targeting RAS signalling pathways in cancer therapy. Julian DownwardNat Rev Cancer200312509763No
81843292164.5196.5898.3Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. N S Jacobson, P TruaxJ Consult Clin Psychol19912002127Yes
81921642164.041.6541.6Histone acetylation in chromatin structure and transcription. M GrunsteinNature19979311776No
82043262163.0118.7159.4Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. C W Elston, I O EllisHistopathology19911757079Yes
82121622162.066.0966.1Diagnosis of Alzheimer's disease. Z S KhachaturianArch Neurol19852864910Yes
82221612161.00.00.0Intracellular aspects of the process of protein synthesis. G PaladeScience19751096303No
82321602160.064.464.4Scaffolds in tissue engineering bone and cartilage. D W HutmacherBiomaterials200011071603Yes
82421592159.080.0480.0Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. H W SteinbuschNeuroscience19817017455Yes
82564752158.3206.8368.9Arlequin (version 3.0): an integrated software package for population genetics data analysis. Laurent Excoffier, Guillaume Laval, Stefan SchneiderEvol Bioinform Online200719325852Yes
82621582158.048.9749.0Chemokines. B J RollinsBlood19979242519No
82786252156.2247.4861.9GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. Berk Hess, Carsten Kutzner, David van der Spoel, Erik LindahlJ Chem Theory Comput200826620784Yes
82843102155.096.1548.1Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. F Sallusto, A LanzavecchiaJ Exp Med19948145033Yes
82921552155.00.00.0Sedimentation Studies Of The Size And Shape Of Dna. F W StudierJ Mol Biol196514290352Yes
83043062153.099.649.8The Bcl-2 protein family: arbiters of cell survival. J M Adams, S CoryScience19989735050No
83121522152.066.2466.2Parkinson's disease: clinical features and diagnosis. J JankovicJ Neurol Neurosurg Psychiatry200818344392No
83221492149.066.5866.6Efficient methods to compute genomic predictions. P M VanRadenJ Dairy Sci200818946147Yes
83321462146.00.00.0The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. W W ClelandBiochim Biophys Acta196314021667Yes
83421452145.00.00.0A new specific color reaction of hexuronic acids. Z DischeJ Biol Chem194720281638Yes
83542862143.0111.5655.8Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Klaus Apel, Heribert HirtAnnu Rev Plant Biol200415377225No
83664292143.0173.857.9ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Kai Wang, Mingyao Li, Hakon HakonarsonNucleic Acids Res201020601685Yes
83742802140.00.00.0The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. H P Misra, I FridovichJ Biol Chem19724623845Yes
83821392139.055.1155.1A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Pascal FriesTrends Cogn Sci200516150631No
83942722136.094.9847.5Mass spectrometry-based proteomics. Ruedi Aebersold, Matthias MannNature200312634793No
84042712135.5140.5670.3Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. R M Ryan, E L DeciAm Psychol200011392867Yes
84142682134.086.9343.5Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Yigong Shi, Joan MassaguéCell200312809600No
84221332133.080.980.9Specific impairments of planning. T ShallicePhilos Trans R Soc Lond B Biol Sci19826125971Yes
84321332133.042.042.0Protein modules and signalling networks. T PawsonNature19957531822No
84442602130.00.00.0A Simplified Lead Citrate Stain For Use In Electron Microscopy. J H Venable, R CoggeshallJ Cell Biol196514287192Yes
84542582129.0106.1653.1Regulation of the mevalonate pathway. J L Goldstein, M S BrownNature19901967820No
84642572128.5157.1678.6The attention system of the human brain. M I Posner, S E PetersenAnnu Rev Neurosci19902183676No
84721282128.046.9847.0Cisplatin: mode of cytotoxic action and molecular basis of resistance. Zahid H SiddikOncogene200314576837No
84821282128.058.3858.4Immunological and inflammatory functions of the interleukin-1 family. Charles A DinarelloAnnu Rev Immunol200919302047No
84921272127.047.1947.2NOX enzymes and the biology of reactive oxygen. J David LambethNat Rev Immunol200415039755No
85063782126.0174.8758.3RNA-Seq: a revolutionary tool for transcriptomics. Zhong Wang, Mark Gerstein, Michael SnyderNat Rev Genet200919015660No
85121252125.050.7950.8Specification of cerebral cortical areas. P RakicScience19883291116No
85221252125.063.6663.7Stress, adaptation, and disease. Allostasis and allostatic load. B S McEwenAnn N Y Acad Sci19989629234No
85321192119.00.00.0The plasma lecithins:cholesterol acyltransferase reaction. J A GlomsetJ Lipid Res19684868699No
85421192119.043.6443.6The molecular biology of memory storage: a dialogue between genes and synapses. E R KandelScience200111691980No
85542302115.0123.9962.0Distributed hierarchical processing in the primate cerebral cortex. D J Felleman, D C Van EssenCereb Cortex19911822724No
85642302115.0101.2850.6Assembly of asparagine-linked oligosaccharides. R Kornfeld, S KornfeldAnnu Rev Biochem19853896128No
85721152115.00.00.0Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. D AminoffBiochem J196113860975Yes
85821122112.088.9789.0A systematic method for clinical description and classification of personality variants. A proposal. C R CloningerArch Gen Psychiatry19873579504Yes
85942222111.0107.3253.7Function and activation of NF-kappa B in the immune system. P A Baeuerle, T HenkelAnnu Rev Immunol19948011280No
86042212110.50.00.0Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. R B Devereux, N ReichekCirculation1977138494Yes
86142212110.50.00.0Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. T V Bliss, T LomoJ Physiol19734727084Yes
86221082108.00.00.0Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. F F JöbsisScience1977929199Yes
86321062106.00.00.0The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. D E AtkinsonBiochemistry19684972613Yes
864168442105.5545.8668.2The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C SiebertN Engl J Med19938366922Yes
86521052105.050.3950.4Patterns of amino acids near signal-sequence cleavage sites. G von HeijneEur J Biochem19836852022Yes
86621022102.049.2949.3Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. G TrinchieriAnnu Rev Immunol19957612223No
86742032101.5160.0980.0Self-rated health and mortality: a review of twenty-seven community studies. E L Idler, Y BenyaminiJ Health Soc Behav19979097506No
86820942094.044.844.8Mammalian G1 cyclins. C J SherrCell19938513492No
86962822094.0183.1861.1Quantum mechanical continuum solvation models. Jacopo Tomasi, Benedetta Mennucci, Roberto CammiChem Rev200516092826Yes
87041862093.0104.5452.3Protein misfolding, functional amyloid, and human disease. Fabrizio Chiti, Christopher M DobsonAnnu Rev Biochem200616756495No
87141862093.099.1149.6AKT/PKB signaling: navigating downstream. Brendan D Manning, Lewis C CantleyCell200717604717No
87220922092.00.00.0Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. T HiguchiJ Pharm Sci196314088963Yes
87341802090.0121.2960.6Angiogenic factors. J Folkman, M KlagsbrunScience19872432664No
87441802090.0108.4254.2A global optimisation method for robust affine registration of brain images. M Jenkinson, S SmithMed Image Anal200111516708Yes
87541752087.5109.1854.6Acute-phase proteins and other systemic responses to inflammation. C Gabay, I KushnerN Engl J Med19999971870No
87641752087.5129.2964.6Missing data: our view of the state of the art. Joseph L Schafer, John W GrahamPsychol Methods200212090408Yes
87741742087.0123.1761.6Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. J S Beckman, W H KoppenolAm J Physiol19968944624No
87862542084.70.00.0Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. B N Ames, J Mccann, E YamasakiMutat Res1975768755Yes
87962542084.7146.1748.7MOLMOL: a program for display and analysis of macromolecular structures. R Koradi, M Billeter, K WüthrichJ Mol Graph19968744573Yes
88041692084.5107.5653.8Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. E Lander, L KruglyakNat Genet19957581446Yes
88141662083.0107.2453.6Myeloid-derived suppressor cells as regulators of the immune system. Dmitry I Gabrilovich, Srinivas NagarajNat Rev Immunol200919197294No
88241642082.0131.1165.6SPSS and SAS procedures for estimating indirect effects in simple mediation models. Kristopher J Preacher, Andrew F HayesBehav Res Methods Instrum Comput200415641418Yes
88320812081.063.8563.9The unbiased estimation of number and sizes of arbitrary particles using the disector. D C SterioJ Microsc19846737468Yes
88420802080.097.3697.4Structural Model Evaluation and Modification: An Interval Estimation Approach. J H SteigerMultivariate Behav Res199026794479Yes
88520772077.00.00.0Isolation by Distance. S WrightGenetics194317247074Yes
88620762076.00.00.0Method For Assay Of Intestinal Disaccharidases. A DahlqvistAnal Biochem196414106916Yes
88720752075.053.5953.6Breast cancer and hormone-replacement therapy in the Million Women Study. Valerie BeralLancet200312927427Yes
88841502075.0111.5455.8The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Karen Bedard, Karl-Heinz KrausePhysiol Rev200717237347No
88962102070.0182.7160.9Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. C E Murry, R B Jennings, K A ReimerCirculation19863769170Yes
89020702070.052.9553.0RGD and other recognition sequences for integrins. E RuoslahtiAnnu Rev Cell Dev Biol19968970741No
89120702070.061.2161.2The nuclear factor NF-kappaB pathway in inflammation. Toby LawrenceCold Spring Harb Perspect Biol200920457564No
89220682068.069.7469.7Working memory. A BaddeleyScience19921736359No
89320642064.091.8791.9Central sensitization: implications for the diagnosis and treatment of pain. Clifford J WoolfPain201120961685No
89420632063.046.2646.3Nitric oxide and the immune response. C BogdanNat Immunol200111577346No
89520622062.00.00.0Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. P MitchellBiol Rev Camb Philos Soc19665329743No
89620622062.00.00.0Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. J W LittlefieldScience196414168277Yes
89720602060.00.00.0Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. J C SkouPhysiol Rev196514337569No
89841172058.587.8343.9A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. G Shaw, R KamenCell19863488815Yes
89961642054.7289.2996.4HISAT: a fast spliced aligner with low memory requirements. Daehwan Kim, Ben Langmead, Steven L SalzbergNat Methods201525751142Yes
90041052052.50.00.0Plaque formation and isolation of pure lines with poliomyelitis viruses. R Dulbecco, M VogtJ Exp Med195413130792Yes
90120522052.069.8569.8A classification of glycosyl hydrolases based on amino acid sequence similarities. B HenrissatBiochem J19911747104Yes
90261552051.70.00.0Immunochemical quantitation of antigens by single radial immunodiffusion. G Mancini, A O Carbonara, J F HeremansImmunochemistry19654956917Yes
90320452045.048.9348.9The inflammatory reflex. Kevin J TraceyNature200212490958No
90420432043.043.0543.0G1 events and regulation of cell proliferation. A B PardeeScience19892683075No
90520422042.057.8457.8Superoxide radical and superoxide dismutases. I FridovichAnnu Rev Biochem19957574505No
90620412041.045.9946.0Complement. First of two parts. M J WalportN Engl J Med200111287977No
90720412041.067.5967.6Biodiesel from microalgae. Yusuf ChistiBiotechnol Adv200717350212No
90861212040.30.00.0Glucose clamp technique: a method for quantifying insulin secretion and resistance. R A DeFronzo, J D Tobin, R AndresAm J Physiol1979382871Yes
90940782039.081.3540.7The fundamental role of epigenetic events in cancer. Peter A Jones, Stephen B BaylinNat Rev Genet200212042769No
91020372037.00.00.0Presidential Address-1976. Social support as a moderator of life stress. S CobbPsychosom Med1976981490Yes
91120362036.083.3483.3A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. E L BradleyArch Surg19938489394No
91261072035.7235.4978.5featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Yang Liao, Gordon K Smyth, Wei ShiBioinformatics201424227677Yes
91320352035.067.4667.5Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. W A CraigClin Infect Dis19989455502No
91420342034.060.0160.0ATP-regulated K+ channels in cardiac muscle. A NomaNature19836310409Yes
91520312031.042.9643.0Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Shimon SakaguchiNat Immunol200515785760No
91640602030.0100.1850.1Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. P Liang, A B PardeeScience19921354393Yes
91720302030.00.00.0Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. G BertaniJ Bacteriol195114888646Yes
91820292029.075.4475.4Epidemiology of viral hepatitis and hepatocellular carcinoma. Hashem B El-SeragGastroenterology201222537432No
91940552027.5118.1359.1Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Michael D Fox, Marcus E RaichleNat Rev Neurosci200717704812No
92020262026.067.7467.7Human error: models and management. J ReasonBMJ200010720363Yes
92120262026.048.8648.9Rab GTPases as coordinators of vesicle traffic. Harald StenmarkNat Rev Mol Cell Biol200919603039No
92220222022.048.2248.2Interleukin-2: inception, impact, and implications. K A SmithScience19883131876No
92320222022.083.7783.8Role of Streptococcus mutans in human dental decay. W J LoescheMicrobiol Rev19863540569No
92420222022.062.3862.4Hybrid porous solids: past, present, future. Gérard FéreyChem Soc Rev200818197340Yes
92520212021.068.3268.3Ethical authorship and publishing. Andrew J S CoatsInt J Cardiol200919046787No
92620212021.067.8467.8The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Claudio HetzNat Rev Mol Cell Biol201222251901No
92720202020.00.00.0Analysis of bacteriophage T7 early RNAs and proteins on slab gels. F W StudierJ Mol Biol19734760132Yes
92820202020.00.00.0Antigen-antibody reactions in gels. O OuchterlonyActa Pathol Microbiol Scand194918143039Yes
92920192019.056.4756.5The importance of selenium to human health. M P RaymanLancet200010963212No
93040382019.0111.7355.9UniFrac: a new phylogenetic method for comparing microbial communities. Catherine Lozupone, Rob KnightAppl Environ Microbiol200516332807Yes
93160552018.3178.5959.5Immunity, inflammation, and cancer. Sergei I Grivennikov, Florian R Greten, Michael KarinCell201020303878No
93240352017.5114.2457.1A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Y Matsumura, H MaedaCancer Res19862946403Yes
93340352017.50.00.0Loss of recent memory after bilateral hippocampal lesions. W B Scoville, B MilnerJ Neurol Neurosurg Psychiatry195713406589Yes
93420172017.054.7654.8T cell exhaustion. E John WherryNat Immunol201121739672No
93540332016.5121.9861.0The number of people with glaucoma worldwide in 2010 and 2020. H A Quigley, A T BromanBr J Ophthalmol200616488940Yes
93620152015.066.6466.6Eye movements in reading and information processing: 20 years of research. K RaynerPsychol Bull19989849112No
93740302015.0102.4251.2Nonparametric permutation tests for functional neuroimaging: a primer with examples. Thomas E Nichols, Andrew P HolmesHum Brain Mapp200211747097Yes
93820132013.052.5252.5Inferring the historical patterns of biological evolution. M PagelNature199910553904Yes
93920132013.038.2338.2Automated electron microscope tomography using robust prediction of specimen movements. David N MastronardeJ Struct Biol200516182563Yes
94020122012.040.0140.0Shelterin: the protein complex that shapes and safeguards human telomeres. Titia de LangeGenes Dev200516166375No
94120122012.058.4758.5Pancreatic cancer. Manuel HidalgoN Engl J Med201020427809No
94220112011.044.6444.6Structural design and molecular evolution of a cytokine receptor superfamily. J F BazanProc Natl Acad Sci U S A19902169613Yes
94340222011.0160.8280.4Extracellular vesicles: exosomes, microvesicles, and friends. Graça Raposo, Willem StoorvogelJ Cell Biol201323420871No
944180932010.3402.8644.8Cytoscape: a software environment for integrated models of biomolecular interaction networks. Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey IdekerGenome Res200314597658Yes
94540182009.0178.3389.2Multiwfn: a multifunctional wavefunction analyzer. Tian Lu, Feiwu ChenJ Comput Chem201222162017Yes
94660242008.0161.0253.7Cortical surface-based analysis. I. Segmentation and surface reconstruction. A M Dale, B Fischl, M I SerenoNeuroimage19999931268Yes
94720072007.053.9854.0The molecular pathology of Alzheimer's disease. D J SelkoeNeuron19911673054No
94820072007.047.8847.9Calcium signaling. D E ClaphamCell19957834745No
94920062006.053.1753.2The heme oxygenase system: a regulator of second messenger gases. M D MainesAnnu Rev Pharmacol Toxicol19979131263No
95040062003.080.8340.4Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. M Gossen, H BujardProc Natl Acad Sci U S A19921319065Yes
95120022002.051.6751.7Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. Jane GlazebrookAnnu Rev Phytopathol200516078883No
95239981999.0109.7354.9New perspectives in cell adhesion: RGD and integrins. E Ruoslahti, M D PierschbacherScience19872821619No
95319991999.054.0254.0Working memory: looking back and looking forward. Alan BaddeleyNat Rev Neurosci200314523382No
95439971998.50.00.0Judgment under Uncertainty: Heuristics and Biases. A Tversky, D KahnemanScience197417835457Yes
95519981998.062.562.5Fetal origins of coronary heart disease. D J BarkerBMJ19957613432No
95619981998.042.6142.6XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. D E McReeJ Struct Biol199910222271Yes
95719981998.057.3257.3Accurate Coulomb-fitting basis sets for H to Rn. Florian WeigendPhys Chem Chem Phys200616633586Yes
95839891994.5110.1455.1Alzheimer's disease: the amyloid cascade hypothesis. J A Hardy, G A HigginsScience19921566067No
95939891994.5105.6552.8The heat-shock proteins. S Lindquist, E A CraigAnnu Rev Genet19882853609No
96019911991.00.00.0The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. U E LoeningBiochem J19675339944Yes
96119911991.084.2884.3Missing data analysis: making it work in the real world. John W GrahamAnnu Rev Psychol200918652544No
96239811990.50.00.0Genetic regulatory mechanisms in the synthesis of proteins. F Jacob, J MonodJ Mol Biol196113718526Yes
96319871987.050.950.9Determination and analysis of urea and guanidine hydrochloride denaturation curves. C N PaceMethods Enzymol19863773761Yes
96419871987.066.4566.5Plant products as antimicrobial agents. M M CowanClin Microbiol Rev199910515903No
96519861986.061.6361.6A two process model of sleep regulation. A A BorbélyHum Neurobiol19827185792Yes
96619851985.039.3539.4NK cell recognition. Lewis L LanierAnnu Rev Immunol200515771571No
96739661983.0151.8775.9The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. P F Lovibond, S H LovibondBehav Res Ther19957726811Yes
96819831983.053.1453.1Descending control of pain. Mark J MillanProg Neurobiol200212034378No
96979171979.2275.6568.9A brief measure for assessing generalized anxiety disorder: the GAD-7. Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd LöweArch Intern Med200616717171Yes
97019781978.040.5640.6Mechanisms of type-I- and type-II-interferon-mediated signalling. Leonidas C PlataniasNat Rev Immunol200515864272No
97119771977.058.258.2Protein oxidation and aging. E R StadtmanScience19921355616No
97219711971.047.1747.2Pathways towards and away from Alzheimer's disease. Mark P MattsonNature200415295589No
97319701970.00.00.0Purinergic nerves. G BurnstockPharmacol Rev19724404211No
974118201970.0269.8445.0NMRPipe: a multidimensional spectral processing system based on UNIX pipes. F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A BaxJ Biomol NMR19958520220Yes
97539401970.081.540.8Mammalian MAP kinase signalling cascades. L Chang, M KarinNature200111242034No
97639371968.5128.1564.1A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Gary J Bennett, Y-K XiePain19882837713Yes
97719681968.064.7164.7Spinal and supraspinal factors in human muscle fatigue. S C GandeviaPhysiol Rev200111581501No
97859001966.7117.4639.2Control of regulatory T cell development by the transcription factor Foxp3. Shohei Hori, Takashi Nomura, Shimon SakaguchiScience200312522256Yes
97919651965.053.6253.6Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. J FolkmanN Engl J Med19957491141No
98019641964.068.0368.0Simplified calculation of body-surface area. R D MostellerN Engl J Med19873657876Yes
98139261963.0103.8251.9Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. M Matsuda, R A DeFronzoDiabetes Care199910480510Yes
98219631963.067.1767.2Qualitative research: standards, challenges, and guidelines. K MalterudLancet200111513933Yes
98319631963.049.8349.8Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Edward V LoftusGastroenterology200415168363Yes
98439251962.597.0448.5Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. G G Glenner, C W WongBiochem Biophys Res Commun19846375662Yes
98578481962.0178.8844.7Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. A Krogh, B Larsson, G von Heijne, E L SonnhammerJ Mol Biol200111152613Yes
98619611961.070.5370.5Determination of glutathione and glutathione disulfide in biological samples. M E AndersonMethods Enzymol19854088074Yes
98719611961.056.4856.5Estimating causal effects from large data sets using propensity scores. D B RubinAnn Intern Med19979382394No
98819611961.041.9542.0Role of angiogenesis in tumor growth and metastasis. Judah FolkmanSemin Oncol200212516034No
98919591959.057.6857.7Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Claudiu T SupuranNat Rev Drug Discov200818167490No
99039181959.0127.2463.6Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. Jeng-Da Chai, Martin Head-GordonPhys Chem Chem Phys200818989472Yes
99158751958.3122.0140.7Rapid and efficient site-specific mutagenesis without phenotypic selection. T A Kunkel, J D Roberts, R A ZakourMethods Enzymol19873323813Yes
99219581958.00.00.0A rating instrument for anxiety disorders. W W ZungPsychosomatics19715172928Yes
99319561956.040.8740.9Mechanisms of intracellular protein transport. J E RothmanNature19947969419No
99439091954.5111.5455.8Application of phylogenetic networks in evolutionary studies. Daniel H Huson, David BryantMol Biol Evol200616221896Yes
99519541954.00.00.0The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. S V BoydenJ Exp Med195114803635Yes
99619491949.054.6354.6The biology of interleukin-6. T KishimotoBlood19892473791No
99738911945.593.2246.6Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. B A Reynolds, S WeissScience19921553558Yes
99819451945.00.00.0Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. J P ChamberlainAnal Biochem1979543547Yes
99919441944.00.00.0Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. A FleckensteinAnnu Rev Pharmacol Toxicol1977326161No
100019431943.082.1982.2The validity and practicality of sun-reactive skin types I through VI. T B FitzpatrickArch Dermatol19883377516Yes
1001116581943.0404.6367.4Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell ParkinInt J Cancer201021351269Yes
100238841942.0180.590.2Stages and processes of self-change of smoking: toward an integrative model of change. J O Prochaska, C C DiClementeJ Consult Clin Psychol19836863699Yes
100338831941.50.00.0Variations in pattern of pubertal changes in girls. W A Marshall, J M TannerArch Dis Child19695785179Yes
100419411941.071.8871.9International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. C HerrmannJ Psychosom Res19979055211No
100538781939.00.00.0Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. I W McLean, P K NakaneJ Histochem Cytochem19744374474Yes
100619391939.054.754.7The blood-brain barrier in health and chronic neurodegenerative disorders. Berislav V ZlokovicNeuron200818215617No
100758151938.3156.7852.3Canonical sampling through velocity rescaling. Giovanni Bussi, Davide Donadio, Michele ParrinelloJ Chem Phys200717212484Yes
100819381938.086.6486.6The Children's Depression, Inventory (CDI). M KovacsPsychopharmacol Bull19854089116Yes
100919381938.035.435.4ATM and related protein kinases: safeguarding genome integrity. Yosef ShilohNat Rev Cancer200312612651No
101038761938.00.00.0Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. W R Morrison, L M SmithJ Lipid Res196414221106Yes
101138741937.085.0442.5Lessons from hereditary colorectal cancer. K W Kinzler, B VogelsteinCell19968861899No
101219361936.058.0758.1Intracellular calcium homeostasis. E CarafoliAnnu Rev Biochem19873304139No
101319361936.00.00.0Analysis of tissue and arterial blood temperatures in the resting human forearm. H H PennesJ Appl Physiol194818887578Yes
101438701935.085.0542.5The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. A J Ridley, A HallCell19921643657Yes
101538691934.50.00.0A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. R F Beers, I W SizerJ Biol Chem195214938361Yes
101619341934.035.9135.9In situ hybridization: an improved whole-mount method for Xenopus embryos. R M HarlandMethods Cell Biol19911811161Yes
101719321932.039.4639.5CpG motifs in bacterial DNA and their immune effects. Arthur M KriegAnnu Rev Immunol200211861616No
101838611930.579.339.6Network biology: understanding the cell's functional organization. Albert-László Barabási, Zoltán N OltvaiNat Rev Genet200414735121No
101957881929.3224.8675.0Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. G Muyzer, E C de Waal, A G UitterlindenAppl Environ Microbiol19937683183Yes
102038561928.00.00.0Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. A C Chang, S N CohenJ Bacteriol1978149110Yes
102138561928.0108.1454.1Insulin-like growth factors and their binding proteins: biological actions. J I Jones, D R ClemmonsEndocr Rev19957758431No
102219281928.042.3842.4The mitogen-activated protein kinase signal transduction pathway. R J DavisJ Biol Chem19938325833No
102319281928.00.00.0Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. M KunitzJ Gen Physiol194719873496Yes
102457801926.7195.0365.0Parallel organization of functionally segregated circuits linking basal ganglia and cortex. G E Alexander, M R DeLong, P L StrickAnnu Rev Neurosci19863085570No
102519241924.054.1854.2The episodic buffer: a new component of working memory? BaddeleyTrends Cogn Sci200011058819Yes
102619221922.081.6581.7A rating scale for drug-induced akathisia. T R BarnesBr J Psychiatry19892574607Yes
102719211921.040.7140.7A cell culture model for T lymphocyte clonal anergy. R H SchwartzScience19902113314Yes
102819181918.00.00.0Influences of glucose loading and of injected insulin on hepatic glucose output. R SteeleAnn N Y Acad Sci195913833973Yes
102919161916.052.9553.0Epidemiology of insomnia: what we know and what we still need to learn. Maurice M OhayonSleep Med Rev200212531146Yes
103019161916.00.00.0Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? J V NeelAm J Hum Genet196213937884Yes
103119151915.065.0565.0Intermediate filaments as mechanical integrators of cellular space. E LazaridesNature19807188712Yes
103219151915.063.0963.1Social cognitive theory: an agentic perspective. A BanduraAnnu Rev Psychol200111148297Yes
103319121912.047.2947.3DNA topoisomerases. J C WangAnnu Rev Biochem19852992360No
103419121912.076.6176.6Approximate entropy as a measure of system complexity. S M PincusProc Natl Acad Sci U S A199111607165Yes
103538221911.094.7447.4Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. M Nei, T GojoboriMol Biol Evol19863444411Yes
103619111911.040.540.5Metastasis to bone: causes, consequences and therapeutic opportunities. Gregory R MundyNat Rev Cancer200212154351No
103719091909.051.2751.3DNA topoisomerase poisons as antitumor drugs. L F LiuAnnu Rev Biochem19892549853No
103819091909.065.2365.2The free-energy principle: a unified brain theory? Karl FristonNat Rev Neurosci201020068583No
103919081908.042.9242.9Biology of natural killer cells. G TrinchieriAdv Immunol19892683611No
104019071907.040.4340.4Molecular bases for circadian clocks. J C DunlapCell19999988221No
104138131906.596.2248.1Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. P J Barnes, M KarinN Engl J Med19979091804No
104238131906.590.6545.3Brown adipose tissue: function and physiological significance. Barbara Cannon, Jan NedergaardPhysiol Rev200414715917No
104319061906.00.00.0Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. A BreslowAnn Surg19705477666Yes
104419061906.044.4644.5A clearer vision for in vivo imaging. R WeisslederNat Biotechnol200111283581No
104538121906.00.00.0Acetylornithinase of Escherichia coli: partial purification and some properties. H J Vogel, D M BonnerJ Biol Chem195613278318Yes
104638111905.5103.7551.9Inositol phosphates and cell signalling. M J Berridge, R F IrvineNature19892550825No
1047171321903.61020.57113.4Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie BrayInt J Cancer201525220842Yes
104819031903.043.7643.8Defensins: antimicrobial peptides of innate immunity. Tomas GanzNat Rev Immunol200312949495No
104919021902.046.7546.8Animal mitochondrial genomes. J L BooreNucleic Acids Res199910101183No
105019021902.00.00.0On estimating the relation between blood group and disease. B WoolfAnn Hum Genet195514388528Yes
105119011901.043.1243.1Signal sequences. The limits of variation. G von HeijneJ Mol Biol19854032478Yes
105219001900.00.00.0The oxidation of ribonuclease with performic acid. C H HirsJ Biol Chem195613319283Yes
105375971899.2196.2349.1Matrix elasticity directs stem cell lineage specification. Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E DischerCell200616923388Yes
105437961898.090.1345.1Base-calling of automated sequencer traces using phred. II. Error probabilities. B Ewing, P GreenGenome Res19989521922Yes
105518971897.00.00.0A modified card sorting test sensitive to frontal lobe defects. H E NelsonCortex19761009768Yes
105618971897.055.2455.2Excitotoxic cell death. D W ChoiJ Neurobiol19921361523No
105718971897.084.5884.6Brain dopamine receptors. P SeemanPharmacol Rev19806117090No
1058208591896.3455.4141.4Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P MesirovProc Natl Acad Sci U S A200516199517Yes
105918961896.00.00.0In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. T R ChenExp Cell Res197765285Yes
106018941894.064.3764.4Keratoconus. Y S RabinowitzSurv Ophthalmol19989493273No
106118921892.057.1957.2Calbindin D-28k and parvalbumin in the rat nervous system. M R CelioNeuroscience19902199841Yes
106218921892.034.934.9Signaling--2000 and beyond. T HunterCell200010647936No
106337791889.596.9548.5Leptin and the regulation of body weight in mammals. J M Friedman, J L HalaasNature19989796811No
106456631887.7143.2147.7GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. R A Jefferson, T A Kavanagh, M W BevanEMBO J19873327686Yes
106518861886.00.00.0Complete nucleotide sequence of the Escherichia coli plasmid pBR322. J G SutcliffeCold Spring Harb Symp Quant Biol1979383387Yes
106656581886.00.00.0Research diagnostic criteria: rationale and reliability. R L Spitzer, J Endicott, E RobinsArch Gen Psychiatry1978655775Yes
106718861886.048.9949.0Flow-mediated endothelial mechanotransduction. P F DaviesPhysiol Rev19957624393No
106837721886.077.7638.9Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Rudolf Jaenisch, Adrian BirdNat Genet200312610534No
106937701885.077.7138.9Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Rik Derynck, Ying E ZhangNature200314534577No
107037621881.00.00.0An efficient mRNA-dependent translation system from reticulocyte lysates. H R Pelham, R J JacksonEur J Biochem1976823012Yes
107137591879.577.2538.6The Wnt signaling pathway in development and disease. Catriona Y Logan, Roel NusseAnnu Rev Cell Dev Biol200415473860No
107275171879.2188.9147.2p53 mutations in human cancers. M Hollstein, D Sidransky, B Vogelstein, C C HarrisScience19911905840No
107318781878.039.5839.6The expanding role of mitochondria in apoptosis. X WangGenes Dev200111711427No
107418781878.057.7557.8Hazards of heavy metal contamination. Lars JärupBr Med Bull200314757716No
107537531876.50.00.0Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. J G Rheinwald, H GreenCell19751052771Yes
107637531876.595.6747.8Cutaneous wound healing. A J Singer, R A ClarkN Engl J Med199910471461No
107718761876.055.155.1Japanese Classification of Gastric Carcinoma - 2nd English Edition - Japanese Gastric Cancer AssociationGastric Cancer199811957040Yes
107837461873.087.1343.6The Fas death factor. S Nagata, P GolsteinScience19957533326No
107918721872.063.2463.2The use of a plus-maze to measure anxiety in the mouse. R G ListerPsychopharmacology (Berl)19873110839Yes
108018721872.041.8441.8Theta oscillations in the hippocampus. György BuzsákiNeuron200211832222No
108137381869.096.1548.1Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Michael T Lin, M Flint BealNature200617051205No
108237371868.5122.3661.2Oxygen toxicity, oxygen radicals, transition metals and disease. B Halliwell, J M GutteridgeBiochem J19846326753No
108318671867.050.0450.0Accurate description of van der Waals complexes by density functional theory including empirical corrections. Stefan GrimmeJ Comput Chem200415224390Yes
108418661866.038.2438.2Signalling pathways of the TNF superfamily: a double-edged sword. Bharat B AggarwalNat Rev Immunol200312949498No
108518651865.049.649.6Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. R D Pascual-MarquiMethods Find Exp Clin Pharmacol200212575463No
108618641864.00.00.0Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. D M NevilleJ Biol Chem19715127429Yes
108737261863.0108.4454.2Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. B J Marshall, J R WarrenLancet19846145023Yes
108818621862.047.6747.7Dopamine, learning and motivation. Roy A WiseNat Rev Neurosci200415152198No
108918621862.049.4249.4A theory of cortical responses. Karl FristonPhilos Trans R Soc Lond B Biol Sci200515937014No
109037231861.5170.3385.2The Health Belief Model: a decade later. N K Janz, M H BeckerHealth Educ Q19846392204No
109118611861.045.8645.9Thioredoxin. A HolmgrenAnnu Rev Biochem19853896121No
109237211860.580.7440.4Raster3D: photorealistic molecular graphics. E A Merritt, D J BaconMethods Enzymol199718488322Yes
109337191859.588.5244.3The acute respiratory distress syndrome. L B Ware, M A MatthayN Engl J Med200010793167No
109418591859.089.7489.7Microplastics in the marine environment. Anthony L AndradyMar Pollut Bull201121742351No
109518581858.033.9934.0The regulation of E2F by pRB-family proteins. N DysonGenes Dev19989694791No
109618561856.049.8949.9Mechanisms of hepatic fibrogenesis. Scott L FriedmanGastroenterology200818471545No
109718541854.051.7451.7The physiology of glucagon-like peptide 1. Jens Juul HolstPhysiol Rev200717928588No
109837051852.585.0242.5Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. T Miyashita, J C ReedCell19957834749Yes
109936971848.50.00.0Polymyositis and dermatomyositis (first of two parts). A Bohan, J B PeterN Engl J Med19751090839No
110055401846.7178.159.4The brain's default network: anatomy, function, and relevance to disease. Randy L Buckner, Jessica R Andrews-Hanna, Daniel L SchacterAnn N Y Acad Sci200818400922No
110136891844.50.00.0Immunoassay of insulin with insulin-antibody precipitate. C N Hales, P J RandleBiochem J196313952078Yes
110218441844.00.00.0The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. G S ManningQ Rev Biophys1978353876No
110355321844.00.00.0A rapid method for the isolation of functional thymus-derived murine lymphocytes. M H Julius, E Simpson, L A HerzenbergEur J Immunol19734587740Yes
110418441844.081.6881.7Role of nrf2 in oxidative stress and toxicity. Qiang MaAnnu Rev Pharmacol Toxicol201323294312No
110555311843.7117.4739.2EMBOSS: the European Molecular Biology Open Software Suite. P Rice, I Longden, A BleasbyTrends Genet200010827456Yes
110618401840.037.537.5Antiviral actions of interferons. C E SamuelClin Microbiol Rev200111585785No
110718401840.059.3759.4TGFβ signalling in context. Joan MassaguéNat Rev Mol Cell Biol201222992590No
110855191839.7179.7759.9Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. C Lord, M Rutter, A Le CouteurJ Autism Dev Disord19947814313Yes
110936771838.589.9345.0The future of genetic studies of complex human diseases. N Risch, K MerikangasScience19968801636Yes
111073521838.0294.8973.7Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg LangBehav Res Methods200919897823Yes
111173491837.2246.8561.7Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. A J Hughes, S E Daniel, L Kilford, A J LeesJ Neurol Neurosurg Psychiatry19921564476Yes
111218371837.053.8953.9The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. G P ChrousosN Engl J Med19957715646No
111318371837.049.2249.2Hepatitis B virus infection. W M LeeN Engl J Med19979392700No
111436741837.072.5236.3Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. M Karin, Y Ben-NeriahAnnu Rev Immunol200010837071No
111573451836.2256.7264.2Reporting results of cancer treatment. A B Miller, B Hoogstraten, M Staquet, A WinklerCancer19817459811Yes
111654991833.0158.2952.8Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. F E Harrell, K L Lee, D B MarkStat Med19968668867No
111718321832.00.00.0A simple fluorometric assay for lipoperoxide in blood plasma. K YagiBiochem Med1976962904Yes
111818321832.039.3739.4Thrombin signalling and protease-activated receptors. S R CoughlinNature200011001069No
111918321832.046.1546.1Cancer chemoprevention with dietary phytochemicals. Young-Joon SurhNat Rev Cancer200314570043No
112018311831.037.6837.7DNA topoisomerases: structure, function, and mechanism. J J ChampouxAnnu Rev Biochem200111395412No
112118291829.037.1637.2Systems biology: a brief overview. Hiroaki KitanoScience200211872829No
112273121828.00.00.0Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. D J Sahn, A DeMaria, J Kisslo, A WeymanCirculation1978709763Yes
112318281828.046.0746.1DAMPs, PAMPs and alarmins: all we need to know about danger. Marco E BianchiJ Leukoc Biol200717032697No
112418251825.068.2968.3Physiological aspects of primary hypertension. B FolkowPhysiol Rev19826461865No
112536501825.0164.1582.1The Brief Symptom Inventory: an introductory report. L R Derogatis, N MelisaratosPsychol Med19836622612Yes
112636501825.094.5347.3The endophenotype concept in psychiatry: etymology and strategic intentions. Irving I Gottesman, Todd D GouldAm J Psychiatry200312668349No
112718241824.040.2440.2The immunopathogenesis of sepsis. Jonathan CohenNature200212490963No
1128145721821.5414.9851.9Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A ErlichScience19882448875Yes
112936431821.5103.651.8Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. Kresse, HafnerPhys Rev B Condens Matter199410010505Yes
113018211821.089.1889.2Performance-oriented assessment of mobility problems in elderly patients. M E TinettiJ Am Geriatr Soc19863944402Yes
113118211821.047.0147.0Negative refraction makes a perfect lens PendryPhys Rev Lett200011041972Yes
113218161816.00.00.0A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. D A RobinsonIEEE Trans Biomed Eng196314121113Yes
113318161816.050.0750.1The extracellular matrix: not just pretty fibrils. Richard O HynesScience200919965464No
113418151815.00.00.0Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. S CohenJ Biol Chem196213880319Yes
113554451815.0135.2745.1APE: Analyses of Phylogenetics and Evolution in R language. Emmanuel Paradis, Julien Claude, Korbinian StrimmerBioinformatics200414734327Yes
113618141814.040.0840.1TRP channels as cellular sensors. David E ClaphamNature200314654832No
113718131813.061.1161.1Physiological actions of taurine. R J HuxtablePhysiol Rev19921731369No
113818131813.051.7451.7Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Gökhan S HotamisligilCell201020303879No
113954341811.3180.7160.2AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. P G Reeves, F H Nielsen, G C FaheyJ Nutr19938229312No
114018111811.00.00.0High-speed scanning in human memory. S SternbergScience19665939936Yes
114172321808.0277.9469.5The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. T F Heatherton, L T Kozlowski, R C Frecker, K O FagerströmBr J Addict19911932883Yes
114218081808.059.1859.2Sick individuals and sick populations. G RoseInt J Epidemiol19853872850Yes
114354191806.3137.2645.8Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Z N Oltvai, C L Milliman, S J KorsmeyerCell19938358790Yes
114418061806.040.9941.0Cellular mechanisms of insulin resistance. G I ShulmanJ Clin Invest200010903330No
114518051805.049.9550.0A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. P J GoodfordJ Med Chem19853892003Yes
114654131804.3126.0642.0A new statistical method for haplotype reconstruction from population data. M Stephens, N J Smith, P DonnellyAm J Hum Genet200111254454Yes
114718031803.00.00.0A theory of cerebellar cortex. D MarrJ Physiol19695784296Yes
114872101802.50.00.0Antibiotic susceptibility testing by a standardized single disk method. A W Bauer, W M Kirby, J C Sherris, M TurckAm J Clin Pathol19665325707Yes
114936041802.00.00.0Mathematical model for studying genetic variation in terms of restriction endonucleases. M Nei, W H LiProc Natl Acad Sci U S A1979291943Yes
115018021802.045.2945.3The global health burden of infection-associated cancers in the year 2002. Donald Maxwell ParkinInt J Cancer200616404738Yes
115118001800.056.0656.1Social determinants of health inequalities. Michael MarmotLancet200515781105Yes
115218001800.038.7938.8The complex language of chromatin regulation during transcription. Shelley L BergerNature200717522673No
115317991799.00.00.0A classification of hand preference by association analysis. M AnnettBr J Psychol19705457503Yes
115417991799.041.5341.5DNA topoisomerases. J C WangAnnu Rev Biochem19968811192No
115517991799.00.00.0On respiratory impairment in cancer cells. O WarburgScience195613351639Yes
115617971797.00.00.0Comparison of the predicted and observed secondary structure of T4 phage lysozyme. B W MatthewsBiochim Biophys Acta19751180967Yes
115717971797.042.242.2Global cancer statistics in the year 2000. D M ParkinLancet Oncol200111905707No
115835931796.5125.1562.6Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. M H Zweig, G CampbellClin Chem19938472349No
115953891796.3174.8358.3Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. R L Spitzer, K Kroenke, J B WilliamsJAMA199910568646Yes
116017961796.043.7443.7Metabolomics--the link between genotypes and phenotypes. Oliver FiehnPlant Mol Biol200211860207No
116117941794.043.7143.7The mitochondrial permeability transition pore and its role in cell death. M CromptonBiochem J199910393078No
116217941794.046.0146.0Drug-like properties and the causes of poor solubility and poor permeability. C A LipinskiJ Pharmacol Toxicol Methods200011274893No
116335861793.0120.360.1Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. R A DeFronzo, E FerranniniDiabetes Care19912044434No
116435851792.590.5445.3Measuring the thickness of the human cerebral cortex from magnetic resonance images. B Fischl, A M DaleProc Natl Acad Sci U S A200010984517Yes
116553771792.3105.0735.0Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Jason D Fontenot, Marc A Gavin, Alexander Y RudenskyNat Immunol200312612578Yes
116671691792.2153.1638.3WebLogo: a sequence logo generator. Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E BrennerGenome Res200415173120Yes
116717921792.040.3340.3A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. J SantaLuciaProc Natl Acad Sci U S A19989465037Yes
116817921792.033.0733.1Mechanisms of alternative pre-messenger RNA splicing. Douglas L BlackAnnu Rev Biochem200312626338No
116935811790.5137.9169.0The biofilm matrix. Hans-Curt Flemming, Jost WingenderNat Rev Microbiol201020676145No
117017901790.052.1452.1Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. A DunaifEndocr Rev19979408743No
117117901790.046.0746.1The hydrogen bond in the solid state. Thomas SteinerAngew Chem Int Ed Engl200212491444Yes
117271591789.8284.4371.1A simple technique for quantitation of low levels of DNA damage in individual cells. N P Singh, M T McCoy, R R Tice, E L SchneiderExp Cell Res19883345800Yes
117317881788.036.9136.9Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. R J KaufmanGenes Dev199910346810No
117417881788.00.00.0The measurement of volume changes in human limbs. R J WhitneyJ Physiol195313085295Yes
117517881788.046.2846.3Interfaces and the driving force of hydrophobic assembly. David ChandlerNature200516193038No
117617881788.072.0372.0Doxil®--the first FDA-approved nano-drug: lessons learned. Yechezkel BarenholzJ Control Release201222484195No
117717871787.067.6167.6Recognition-by-components: a theory of human image understanding. Irving BiedermanPsychol Rev19873575582Yes
117817871787.065.9365.9Why patients use alternative medicine: results of a national study. J A AstinJAMA19989605899Yes
117935731786.575.1137.6Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. C D Nobes, A HallCell19957536630Yes
118035711785.5122.8161.4Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. G Di Chiara, A ImperatoProc Natl Acad Sci U S A19882899326Yes
118117851785.059.0859.1Heavy metal intensification of DAB-based HRP reaction product. J C AdamsJ Histochem Cytochem19817252134Yes
118271381784.5176.7744.2Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. A Shevchenko, M Wilm, O Vorm, M MannAnal Chem19968779443Yes
118317821782.00.00.0Estimability and estimation in case-referent studies. O MiettinenAm J Epidemiol19761251836Yes
118417821782.097.0497.0The assessment of clinical skills/competence/performance. G E MillerAcad Med19902400509Yes
118517821782.044.5544.5The dawning era of polymer therapeutics. Ruth DuncanNat Rev Drug Discov200312750738No
118653451781.7177.1459.0FastTree 2--approximately maximum-likelihood trees for large alignments. Morgan N Price, Paramvir S Dehal, Adam P ArkinPLoS One201020224823Yes
118717811781.058.5458.5Health consequences of intimate partner violence. Jacquelyn C CampbellLancet200211965295No
118817811781.046.6246.6Follicular helper CD4 T cells (TFH). Shane CrottyAnnu Rev Immunol201121314428No
118917781778.00.00.0The influence of some cations on an adenosine triphosphatase from peripheral nerves. J C SkouBiochim Biophys Acta195713412736Yes
119035531776.50.00.0Maturation of the head of bacteriophage T4. I. DNA packaging events. U K Laemmli, M FavreJ Mol Biol19734204102Yes
119117761776.0103.95104.0Determination and quantification of content validity. M R LynnNurs Res19863640358Yes
119235481774.00.00.0Multiple receptors for dopamine. J W Kebabian, D B CalneNature1979215920No
119317741774.035.1235.1Approaching the asymptote? Evolution and revolution in immunology. C A JanewayCold Spring Harb Symp Quant Biol19892700931No
119417741774.042.8642.9Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. B L WajchenbergEndocr Rev200011133069No
119517741774.045.5645.6Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Fiona TurnbullLancet200314615107Yes
119617731773.00.00.0The etiology of chondromalacia patellae. R E OuterbridgeJ Bone Joint Surg Br196114038135Yes
119717731773.061.1961.2Guided Search 2.0 A revised model of visual search. J M WolfePsychon Bull Rev199424203471Yes
119817721772.00.00.0Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. U UngerstedtActa Physiol Scand Suppl19714332693Yes
119917711771.00.00.0The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. S HestrinJ Biol Chem194918133390Yes
120017701770.039.139.1Developmental regulation of the growth plate. Henry M KronenbergNature200312748651No
120135401770.0109.2254.6Nonparametric statistical testing of EEG- and MEG-data. Eric Maris, Robert OostenveldJ Neurosci Methods200717517438Yes
120217691769.057.757.7Calculation of substrate oxidation rates in vivo from gaseous exchange. K N FraynJ Appl Physiol Respir Environ Exerc Physiol19836618956Yes
1203123731767.6284.3840.6Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank SpelemanGenome Biol200212184808Yes
120435291764.593.9147.0Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. K D McCarthy, J de VellisJ Cell Biol19806248568Yes
120535271763.586.0543.0Protein folding in the cell. M J Gething, J SambrookNature19921731198No
120617621762.00.00.0Transplacental carcinogenesis by stilbestrol. J FolkmanN Engl J Med19715556579Yes
120717611761.040.8240.8Neutrophils and immunity: challenges and opportunities. Carl NathanNat Rev Immunol200616498448No
120817611761.052.2552.2Intestinal mucosal barrier function in health and disease. Jerrold R TurnerNat Rev Immunol200919855405No
120917601760.055.4655.5The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. B L FredricksonAm Psychol200111315248Yes
121017591759.00.00.0Protein denaturation. C TanfordAdv Protein Chem19684882248No
121135181759.0113.156.5Efficient pseudopotentials for plane-wave calculations. Troullier, MartinsPhys Rev B Condens Matter19919997467Yes
121252761758.7175.1558.4Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. L Excoffier, P E Smouse, J M QuattroGenetics19921644282Yes
121335161758.067.0633.5Rho GTPases in cell biology. Sandrine Etienne-Manneville, Alan HallNature200212478284No
121417571757.043.4443.4Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Jeffrey A EngelmanNat Rev Cancer200919629070No
121517561756.049.4349.4New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. R Y TsienBiochemistry19806770893Yes
121617561756.036.8336.8An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. R M EsnoufJ Mol Graph Model19979385560Yes
121717551755.050.1150.1Biofilms: microbial life on surfaces. Rodney M DonlanEmerg Infect Dis200212194761No
121817541754.062.2362.2The role of hormone receptors and GTP-regulatory proteins in membrane transduction. M RodbellNature19806101906Yes
121917541754.047.9748.0G proteins and dual control of adenylate cyclase. A G GilmanCell19846321035Yes
122017531753.082.0182.0Determinants of low birth weight: methodological assessment and meta-analysis. M S KramerBull World Health Organ19873322602No
122117521752.00.00.0Positional information and the spatial pattern of cellular differentiation. L WolpertJ Theor Biol19694390734Yes
122235001750.0153.8276.9The MOS social support survey. C D Sherbourne, A L StewartSoc Sci Med19912035047Yes
122317481748.035.1735.2Notch signalling: a simple pathway becomes complex. Sarah J BrayNat Rev Mol Cell Biol200616921404No
122417471747.039.4239.4The distribution of secondary growths in cancer of the breast. 1889. S PagetCancer Metastasis Rev19892673568No
122517471747.0133.94133.9Minimap2: pairwise alignment for nucleotide sequences. Heng LiBioinformatics201829750242Yes
122617461746.058.958.9Drugs of abuse: anatomy, pharmacology and function of reward pathways. G F KoobTrends Pharmacol Sci19921604710No
122769821745.5282.7570.7Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanJ Clin Epidemiol200919631508No
122817451745.040.3440.3Steroid receptor regulated transcription of specific genes and gene networks. K R YamamotoAnnu Rev Genet19853909942No
122917451745.062.2762.3A cortical network for directed attention and unilateral neglect. M M MesulamAnn Neurol19817032417No
123017451745.054.8754.9An overview of brominated flame retardants in the environment. Cynthia A de WitChemosphere200211999784No
123152311743.7137.1545.7Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. G S Hotamisligil, N S Shargill, B M SpiegelmanScience19937678183Yes
123217431743.00.00.0A personality scale of manifest anxiety. J A TaylorJ Abnorm Psychol195313052352Yes
123317431743.051.3551.4MYC on the path to cancer. Chi V DangCell201222464321No
123434851742.50.00.0A complementation analysis of the restriction and modification of DNA in Escherichia coli. H W Boyer, D Roulland-DussoixJ Mol Biol19694896022Yes
123517421742.071.271.2Perception of risk. P SlovicScience19873563507Yes
123617421742.068.3668.4Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. H U WittchenJ Psychiatr Res19948064641No
123717401740.045.0645.1The pathophysiology of tumor necrosis factors. P VassalliAnnu Rev Immunol19921590993No
123817401740.072.6672.7The Resonating Valence Bond State in La2CuO4 and Superconductivity. P W AndersonScience198717818979Yes
123917371737.046.4346.4Interleukin-6: an overview. J Van SnickAnnu Rev Immunol19902188664No
124017371737.045.0445.0Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Scott L FriedmanPhysiol Rev200818195085No
124117351735.00.00.0Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. M J CasadabanJ Mol Biol1976781293Yes
124217341734.057.7657.8Epidemiological features of chronic low-back pain. G B AnderssonLancet199910470716No
124317331733.052.6452.6Inhibited spontaneous emission in solid-state physics and electronics. YablonovitchPhys Rev Lett198710034639Yes
124434651732.575.9638.0Cell death: critical control points. Nika N Danial, Stanley J KorsmeyerCell200414744432No
124534631731.588.744.4The biology of vascular endothelial growth factor. N Ferrara, T Davis-SmythEndocr Rev19979034784No
1246121181731.1298.6942.7Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya YamanakaCell200718035408Yes
124717311731.055.1255.1PsychoPy--Psychophysics software in Python. Jonathan W PeirceJ Neurosci Methods200717254636Yes
124851811727.0113.8337.9Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. A Nicholls, K A Sharp, B HonigProteins19911758883Yes
124934541727.093.7946.9Prediction of protein antigenic determinants from amino acid sequences. T P Hopp, K R WoodsProc Natl Acad Sci U S A19816167991Yes
125017271727.039.0939.1The synaptic vesicle cycle: a cascade of protein-protein interactions. T C SüdhofNature19957791897No
125169051726.2171.1642.8Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. C A Lipinski, F Lombardo, B W Dominy, P J FeeneyAdv Drug Deliv Rev200111259830No
125217261726.00.00.0ATPase activity of myosin correlated with speed of muscle shortening. M BárányJ Gen Physiol19674227924Yes
125317241724.050.4250.4Flavonoids as antioxidants. P G PiettaJ Nat Prod200010924197No
125417231723.062.3262.3Cyclosporine. B D KahanN Engl J Med19892687689No
125517231723.043.0843.1Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. D LavanchyJ Viral Hepat200414996343No
125617221722.064.4564.5Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. D R JaneroFree Radic Biol Med19902079232No
125717211721.036.5136.5Structure and regulation of voltage-gated Ca2+ channels. W A CatterallAnnu Rev Cell Dev Biol200011031246No
125817211721.035.8535.9MicroRNA biogenesis: coordinated cropping and dicing. V Narry KimNat Rev Mol Cell Biol200515852042No
125917211721.041.8241.8Integrating cell-signalling pathways with NF-kappaB and IKK function. Neil D PerkinsNat Rev Mol Cell Biol200717183360No
126034411720.594.1847.1Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. K B Mullis, F A FaloonaMethods Enzymol19873431465Yes
126117191719.00.00.0Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. J N DumontJ Morphol19724109871Yes
126217191719.00.00.0Dynamic properties of mammalian skeletal muscles. R I ClosePhysiol Rev19724256989No
126317191719.047.1947.2An index to quantify an individual's scientific research output. J E HirschProc Natl Acad Sci U S A200516275915Yes
126417181718.036.7536.8Mechanisms of cancer drug resistance. Michael M GottesmanAnnu Rev Med200211818492No
126517181718.032.4332.4CD4+ CD25+ suppressor T cells: more questions than answers. Ethan M ShevachNat Rev Immunol200212093005No
126617171717.00.00.0Dendritic organization in the neurons of the visual and motor cortices of the cat. D A ShollJ Anat195313117757Yes
126751501716.7232.8677.6Some statistical methods useful in circulation research. S Wallenstein, C L Zucker, J L FleissCirc Res19807379260Yes
126868591714.8135.0333.8Transformation of intact yeast cells treated with alkali cations. H Ito, Y Fukuda, K Murata, A KimuraJ Bacteriol19836336730Yes
126934291714.573.1836.6Identification of common molecular subsequences. T F Smith, M S WatermanJ Mol Biol19817265238Yes
127034291714.592.1846.1Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering Nie, EmoryScience19979027306Yes
127117141714.00.00.0The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. R RossJ Cell Biol19714327464Yes
127251411713.7100.9633.7Surfing the p53 network. B Vogelstein, D Lane, A J LevineNature200011099028No
127334251712.591.1745.6Cloned glutamate receptors. M Hollmann, S HeinemannAnnu Rev Neurosci19948210177No
127434251712.5112.656.3Wnt/β-catenin signaling and disease. Hans Clevers, Roel NusseCell201222682243No
127517111711.035.8935.9DNA methylation and human disease. Keith D RobertsonNat Rev Genet200516136652No
127617091709.036.4936.5Molecular regulation of vessel maturation. Rakesh K JainNat Med200312778167No
127717081708.054.6554.6Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. M ZasloffProc Natl Acad Sci U S A19873299384Yes
127834161708.00.00.0The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. A E Bolton, W M HunterBiochem J19734733239Yes
127917071707.00.00.0Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. E M WitkinBacteriol Rev1976795416No
128017071707.056.7656.8Pineal melatonin: cell biology of its synthesis and of its physiological interactions. R J ReiterEndocr Rev19911649044No
128151171705.7117.4139.1Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Michael W Pfaffl, Graham W Horgan, Leo DempfleNucleic Acids Res200211972351Yes
128217051705.054.7154.7Glutamate: a neurotransmitter in mammalian brain. F FonnumJ Neurochem19846139418No
128317051705.046.7446.7Network pharmacology: the next paradigm in drug discovery. Andrew L HopkinsNat Chem Biol200818936753No
128434091704.598.6549.3The inflammasomes. Kate Schroder, Jurg TschoppCell201020303873No
128517021702.00.00.0Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. M Wong-RileyBrain Res1979223730Yes
128617021702.058.1558.1Large-scale neurocognitive networks and distributed processing for attention, language, and memory. M M MesulamAnn Neurol19902260847No
128734021701.086.1143.1Matrix metalloproteinases. H Nagase, J F WoessnerJ Biol Chem199910419448No
128816991699.041.1241.1Type III protein secretion systems in bacterial pathogens of animals and plants. C J HueckMicrobiol Mol Biol Rev19989618447No
128916991699.045.4945.5What is cognitive reserve? Theory and research application of the reserve concept. Yaakov SternJ Int Neuropsychol Soc200211939702No
129033971698.50.00.0Receptive fields and functional architecture of monkey striate cortex. D H Hubel, T N WieselJ Physiol19684966457Yes
129116981698.00.00.0Evolutionary rate at the molecular level. M KimuraNature19685637732Yes
129216981698.00.00.0A graphic method for the determination and presentation of binding parameters in a complex system. H E RosenthalAnal Biochem19676048188Yes
129316971697.037.6937.7Exploring complex networks. S H StrogatzNature200111258382No
129416961696.00.00.0The statistical analysis of enzyme kinetic data. W W ClelandAdv Enzymol Relat Areas Mol Biol19674881884No
129516961696.061.2161.2Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Sergio PecorelliInt J Gynaecol Obstet200919367689No
129616951695.045.9946.0Integrins. E RuoslahtiJ Clin Invest19911985087No
129716951695.057.3257.3Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. C E MogensenN Engl J Med19846690964Yes
1298169451694.5538.3753.8Measurement of protein using bicinchoninic acid. P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C KlenkAnal Biochem19853843705Yes
129916941694.044.7244.7Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. G C WalkerMicrobiol Rev19846371470No
130084621692.4233.1246.6Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary KingDiabetes Care200415111519Yes
130116921692.00.00.0Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. A F HabeebAnal Biochem19664161471Yes
130233841692.00.00.0A "Direct-Coloring" Thiocholine Method For Cholinesterases. M J Karnovsky, L RootsJ Histochem Cytochem196414187330Yes
130316921692.039.8939.9Fabrication of novel biomaterials through molecular self-assembly. Shuguang ZhangNat Biotechnol200314520402No
130433841692.082.2641.1Liver fibrosis. Ramón Bataller, David A BrennerJ Clin Invest200515690074No
130516911691.031.931.9How eukaryotic transcriptional activators work. M PtashneNature19883050531No
130616911691.068.1768.2Predicting basal metabolic rate, new standards and review of previous work. W N SchofieldHum Nutr Clin Nutr19854044297Yes
130716911691.056.1756.2Global epidemiology of oral and oropharyngeal cancer. Saman WarnakulasuriyaOral Oncol200918804401No
130816901690.00.00.0Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. A KrishanJ Cell Biol197549354Yes
130916901690.041.4241.4Evolutionary relationship of DNA sequences in finite populations. F TajimaGenetics19836628982Yes
131016901690.034.7934.8Cancer and the chemokine network. Fran BalkwillNat Rev Cancer200415229479No
131116891689.00.00.0Why genes in pieces? W GilbertNature1978622185Yes
131216891689.00.00.0The general adaptation syndrome and the diseases of adaptation. H SelyeJ Clin Endocrinol Metab194621025115Yes
131333771688.595.4247.7ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. B Ravel, M NewvilleJ Synchrotron Radiat200515968136Yes
131416861686.00.00.0Areas, volumes, packing and protein structure. F M RichardsAnnu Rev Biophys Bioeng1977326146No
131516861686.056.7656.8The crisis in antibiotic resistance. H C NeuScience19921509257No
131616861686.040.840.8The molecular genetics of cancer. J M BishopScience19873541204No
131716851685.044.8344.8Using circular dichroism spectra to estimate protein secondary structure. Norma J GreenfieldNat Protoc200617406547Yes
131816831683.049.6549.6Introduction and General Overview of Cyclodextrin Chemistry. József SzejtliChem Rev199811848947Yes
1319117751682.1432.2461.7Assessing the quality of reports of randomized clinical trials: is blinding necessary? A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuayControl Clin Trials19968721797Yes
132016821682.00.00.0The theory and applications of the exchange of inert gas at the lungs and tissues. S S KetyPharmacol Rev195114833874Yes
132116801680.00.00.0Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. J SpizizenProc Natl Acad Sci U S A195816590310Yes
132216781678.00.00.0Plastic Embedding Mixtures For Use In Electron Microscopy. H H MollenhauerStain Technol196414127791Yes
132367091677.2226.8856.7clusterProfiler: an R package for comparing biological themes among gene clusters. Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu HeOMICS201222455463Yes
132433541677.094.1747.1Biochemistry of multidrug resistance mediated by the multidrug transporter. M M Gottesman, I PastanAnnu Rev Biochem19938102521No
132516771677.045.1345.1Dengue and dengue hemorrhagic fever. D J GublerClin Microbiol Rev19989665979No
132667041676.00.00.0Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. E A Jaffe, R L Nachman, C G Becker, C R MinickJ Clin Invest19734355998Yes
132716751675.061.261.2Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). G G GlennerN Engl J Med19806154243No
132816741674.039.8439.8Solvent-accessible surfaces of proteins and nucleic acids. M L ConnollyScience19836879170Yes
132916741674.058.7258.7Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? B HalliwellLancet19947915779No
133016741674.046.9547.0Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. Robert E MarxJ Oral Maxillofac Surg200312966493Yes
133116741674.00.00.0Method for the determination of hexosamines in tissues. N F BoasJ Biol Chem195313117829Yes
133216741674.055.555.5Hypoxia-inducible factors in physiology and medicine. Gregg L SemenzaCell201222304911No
133316731673.042.2542.2Episodic memory: from mind to brain. Endel TulvingAnnu Rev Psychol200211752477Yes
133416731673.050.9651.0Infrared spectroscopy of proteins. Andreas BarthBiochim Biophys Acta200717692815No
133533451672.572.3236.2Integrin signaling. F G Giancotti, E RuoslahtiScience199910446041No
133650171672.3197.9466.0Effect of the damping function in dispersion corrected density functional theory. Stefan Grimme, Stephan Ehrlich, Lars GoerigkJ Comput Chem201121370243Yes
133733431671.574.7937.4Monocyte and macrophage heterogeneity. Siamon Gordon, Philip R TaylorNat Rev Immunol200516322748No
133816711671.00.00.0Drugs which inhibit prostaglandin biosynthesis. R J FlowerPharmacol Rev19744208101Yes
133916711671.035.3135.3The effect of infections on susceptibility to autoimmune and allergic diseases. Jean-Francois BachN Engl J Med200212239261No
134016701670.00.00.0Mode of cell migration to the superficial layers of fetal monkey neocortex. P RakicJ Comp Neurol19724624784Yes
134116701670.00.00.0Chromatographic Separation Of Human Brain Gangliosides. L SvennerholmJ Neurochem196314066623Yes
134233381669.077.2138.6Amino acid substitution matrices from protein blocks. S Henikoff, J G HenikoffProc Natl Acad Sci U S A19921438297Yes
134316691669.056.4456.4Serum albumin. T PetersAdv Protein Chem19853904348No
134416681668.052.7352.7The atom economy--a search for synthetic efficiency. B M TrostScience19911962206Yes
134516681668.00.00.0An improved procedure for serum creatine phosphokinase determination. S B RosalkiJ Lab Clin Med19674381359Yes
134616671667.00.00.0Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. J A MillerCancer Res19704915745No
134716671667.047.8547.9Cell biology and molecular basis of denitrification. W G ZumftMicrobiol Mol Biol Rev19979409151No
134833331666.581.1940.6PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. Alexander W Schüttelkopf, Daan M F van AaltenActa Crystallogr D Biol Crystallogr200415272157Yes
134966661666.5178.6244.7Epithelial-mesenchymal transitions in development and disease. Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela NietoCell200919945376No
135033321666.00.00.0Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. J Marmur, P DotyJ Mol Biol196214470099Yes
135116651665.058.1558.1Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. A H ConneyCancer Res19826814745No
135216651665.046.3546.4Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. H LeVineProtein Sci19938453378Yes
135333281664.00.00.0Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. M Grunstein, D S HognessProc Natl Acad Sci U S A19751105573Yes
135416641664.039.0139.0The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. D M KingsleyGenes Dev19948299934No
135533281664.089.6444.8A scaling normalization method for differential expression analysis of RNA-seq data. Mark D Robinson, Alicia OshlackGenome Biol201020196867Yes
135633231661.5123.4261.7Microenvironmental regulation of tumor progression and metastasis. Daniela F Quail, Johanna A JoyceNat Med201324202395No
135716601660.00.00.0Carbonic anhydrase: chemistry, physiology, and inhibition. T H MarenPhysiol Rev19674964060No
135816581658.086.9587.0Conservation of resources. A new attempt at conceptualizing stress. S E HobfollAm Psychol19892648906No
135916571657.046.1646.2The comet assay for DNA damage and repair: principles, applications, and limitations. Andrew R CollinsMol Biotechnol200415004294No
136066241656.0135.5533.9Stem cells, cancer, and cancer stem cells. T Reya, S J Morrison, M F Clarke, I L WeissmanNature200111689955No
136116561656.044.144.1The genetics of ageing. Cynthia J KenyonNature201020336132No
136233111655.577.1638.6Parkinson's disease: mechanisms and models. William Dauer, Serge PrzedborskiNeuron200312971891No
136316551655.037.7337.7Effects of cytochalasin and phalloidin on actin. J A CooperJ Cell Biol19873312229No
136433081654.00.00.0New method for quantitative determination of uronic acids. N Blumenkrantz, G Asboe-HansenAnal Biochem19734269305Yes
136516541654.00.00.0Pedigrees of some mutant strains of Escherichia coli K-12. B J BachmannBacteriol Rev19724568763No
136633081654.00.00.0The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. T Omura, R SatoJ Biol Chem196414209972Yes
136716531653.049.0249.0Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. E M WassermannElectroencephalogr Clin Neurophysiol19989474057No
136816531653.032.0432.0Cellular roles of DNA topoisomerases: a molecular perspective. James C WangNat Rev Mol Cell Biol200212042765No
136966041651.0153.6738.4Use of T7 RNA polymerase to direct expression of cloned genes. F W Studier, A H Rosenberg, J J Dunn, J W DubendorffMethods Enzymol19902199796Yes
137016511651.056.8856.9Grounded cognition. Lawrence W BarsalouAnnu Rev Psychol200817705682No
137133011650.5144.6572.3A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. J G Snodgrass, M VanderwartJ Exp Psychol Hum Learn19807373248Yes
137232951647.5109.2854.6Role of free radicals and catalytic metal ions in human disease: an overview. B Halliwell, J M GutteridgeMethods Enzymol19902172697No
137332951647.593.3846.7Building better batteries. M Armand, J-M TarasconNature200818256660No
137482331646.6212.4542.5Mapping and quantifying mammalian transcriptomes by RNA-Seq. Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara WoldNat Methods200818516045Yes
137532931646.585.642.8Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Christian Haass, Dennis J SelkoeNat Rev Mol Cell Biol200717245412No
137632921646.084.8342.4Receptors for purines and pyrimidines. V Ralevic, G BurnstockPharmacol Rev19989755289No
137716451645.00.00.0The micronucleus test. W SchmidMutat Res197548190Yes
137816451645.045.545.5Oxidative stress hypothesis in Alzheimer's disease. W R MarkesberyFree Radic Biol Med19979165306No
137916451645.041.3441.3Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Paul M RidkerCirculation200312551853No
138016451645.00.00.0A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. D MattinglyJ Clin Pathol196214471419Yes
138149341644.7157.5452.5Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. H Esterbauer, R J Schaur, H ZollnerFree Radic Biol Med19911937131No
138232891644.586.1143.1Quantum dot bioconjugates for ultrasensitive nonisotopic detection. W C Chan, S NieScience19989748158Yes
1383164421644.2528.1952.8The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S LuthraArthritis Rheum19883358796Yes
138416421642.045.1245.1Chlorpromazine equivalent doses for the newer atypical antipsychotics. Scott W WoodsJ Clin Psychiatry200312823080No
138532831641.50.00.0Method for the isolation of intact islets of Langerhans from the rat pancreas. P E Lacy, M KostianovskyDiabetes19675333500Yes
138616411641.036.236.2Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. S L FriedmanJ Biol Chem200010644669No
138732801640.089.1344.6Protein structure prediction on the Web: a case study using the Phyre server. Lawrence A Kelley, Michael J E SternbergNat Protoc200919247286Yes
138816391639.052.6452.6Metallothionein. D H HamerAnnu Rev Biochem19863527054No
138981931638.6933.52186.7MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro TamuraMol Biol Evol201829722887Yes
139032771638.5102.2751.1Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. F Denizot, R LangJ Immunol Methods19863486233Yes
139165541638.5174.5443.6Cancer-related inflammation. Alberto Mantovani, Paola Allavena, Antonio Sica, Frances BalkwillNature200818650914No
139216371637.045.7245.7Turnover of inositol phospholipids and signal transduction. Y NishizukaScience19846147898No
139316371637.038.6438.6NADPH oxidase: an update. B M BabiorBlood199910029572No
139432731636.50.00.0Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. M Mihara, M UchiyamaAnal Biochem1978655387Yes
139532691634.50.00.0Variations in the pattern of pubertal changes in boys. W A Marshall, J M TannerArch Dis Child19705440182Yes
139616331633.032.4432.4Hox genes in vertebrate development. R KrumlaufCell19947913880No
139732641632.078.7939.4The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. P Angel, M KarinBiochim Biophys Acta19911751545No
139816321632.034.0234.0Structural features in eukaryotic mRNAs that modulate the initiation of translation. M KozakJ Biol Chem19911939050No
139932641632.065.3832.7SIFT: Predicting amino acid changes that affect protein function. Pauline C Ng, Steven HenikoffNucleic Acids Res200312824425Yes
140032631631.593.046.5Biofilms: survival mechanisms of clinically relevant microorganisms. Rodney M Donlan, J William CostertonClin Microbiol Rev200211932229No
140116311631.00.00.0RNA-dependent DNA polymerase in virions of RNA tumour viruses. D BaltimoreNature19704316300Yes
140216301630.032.4432.4Cell cycle checkpoints: preventing an identity crisis. S J ElledgeScience19968939848No
140316301630.040.140.1Inflammatory bowel disease: etiology and pathogenesis. C FiocchiGastroenterology19989649475No
140416291629.00.00.0Chromatin structure: a repeating unit of histones and DNA. R D KornbergScience19744825889Yes
140532571628.5128.5764.3Assays of glutathione peroxidase. L Flohé, W A GünzlerMethods Enzymol19846727659Yes
140616281628.051.9251.9Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? George A BonannoAm Psychol200414736317No
140732541627.00.00.0A fluorometric method for determination of oxidized and reduced glutathione in tissues. P J Hissin, R HilfAnal Biochem1976962076Yes
140816261626.067.7367.7Negative symptoms in schizophrenia. Definition and reliability. N C AndreasenArch Gen Psychiatry19827165477Yes
140997561626.0280.4346.7Positional cloning of the mouse obese gene and its human homologue. Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M FriedmanNature19947984236Yes
141032501625.088.9844.5Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. Steven E Nissen, Kathy WolskiN Engl J Med200717517853Yes
141132501625.096.4848.2The unfolded protein response: from stress pathway to homeostatic regulation. Peter Walter, David RonScience201122116877No
141232491624.571.4735.7Protein structure comparison by alignment of distance matrices. L Holm, C SanderJ Mol Biol19938377180Yes
141316231623.058.6958.7Cell damage in the brain: a speculative synthesis. B K SiesjöJ Cereb Blood Flow Metab19816276420No
141416221622.041.9642.0Neurotrophins and neuronal plasticity. H ThoenenScience19957570017No
141516221622.043.9343.9P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation. Berk HessJ Chem Theory Comput200826619985Yes
141632431621.590.1645.1The mirror-neuron system. Giacomo Rizzolatti, Laila CraigheroAnnu Rev Neurosci200415217330No
141732421621.0138.5969.3miRBase: annotating high confidence microRNAs using deep sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201424275495Yes
141816201620.049.0549.0Extracellular ATP: effects, sources and fate. J L GordonBiochem J19863006665No
141916181618.070.9470.9Neurogenetic adaptive mechanisms in alcoholism. C R CloningerScience19872882604Yes
142016151615.054.9755.0Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Leonardo PantoniLancet Neurol201020610345No
1421112921613.1288.6341.2Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M NathanN Engl J Med200211832527Yes
142216121612.037.2237.2Cellular oncogenes and retroviruses. J M BishopAnnu Rev Biochem19836351725No
142316121612.030.3430.3Cyclin-dependent kinases: engines, clocks, and microprocessors. D O MorganAnnu Rev Cell Dev Biol19979442875No
142416111611.035.0535.0Excitatory actions of gaba during development: the nature of the nurture. Yehezkel Ben-AriNat Rev Neurosci200212209121No
142516111611.038.2138.2Recognition of microorganisms and activation of the immune response. Ruslan MedzhitovNature200717943118No
142616101610.080.0880.1Statistics corner: A guide to appropriate use of correlation coefficient in medical research. M M MukakaMalawi Med J201223638278Yes
142716091609.034.8734.9Protein homology detection by HMM-HMM comparison. Johannes SödingBioinformatics200515531603Yes
142848251608.3149.3449.8Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. P A Wolf, R D Abbott, W B KannelStroke19911866765Yes
142916081608.050.8350.8Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. D W ChoiTrends Neurosci19882469166No
143016081608.050.3650.4A measure of population subdivision based on microsatellite allele frequencies. M SlatkinGenetics19957705646Yes
143116081608.037.9237.9Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. S A BustinJ Mol Endocrinol200212200227No
143216071607.047.3347.3Metalloproteinases and their inhibitors in matrix remodeling. L M MatrisianTrends Genet19902132731No
143332141607.079.1639.6Neuronal oscillations in cortical networks. György Buzsáki, Andreas DraguhnScience200415218136No
143448191606.3114.4438.1Inflammation and atherosclerosis. Peter Libby, Paul M Ridker, Attilio MaseriCirculation200211877368No
143532121606.077.3538.7Rapid and sensitive protein similarity searches. D J Lipman, W R PearsonScience19852983426Yes
143616061606.00.00.0Computerized transverse axial scanning (tomography). 1. Description of system. G N HounsfieldBr J Radiol19734757352Yes
143732121606.0120.3560.2Shifting the genomic gold standard for the prokaryotic species definition. Michael Richter, Ramon Rosselló-MóraProc Natl Acad Sci U S A200919855009Yes
143832121606.0112.7156.4Macrophage plasticity and polarization: in vivo veritas. Antonio Sica, Alberto MantovaniJ Clin Invest201222378047No
143916041604.035.1235.1Bone morphogenetic proteins: multifunctional regulators of vertebrate development. B L HoganGenes Dev19968682290No
144016041604.045.3745.4Leptospirosis. P N LevettClin Microbiol Rev200111292640No
144132081604.070.7535.4Insulin signalling and the regulation of glucose and lipid metabolism. A R Saltiel, C R KahnNature200111742412Yes
144216031603.048.6948.7Classification of inflammatory bowel disease. J E Lennard-JonesScand J Gastroenterol Suppl19892617184Yes
144316031603.029.6229.6Maximum-likelihood density modification. T C TerwilligerActa Crystallogr D Biol Crystallogr200010944333Yes
144416031603.00.00.0Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. E G GrayJ Anat195913829103Yes
144532031601.578.6739.3CAP3: A DNA sequence assembly program. X Huang, A MadanGenome Res199910508846Yes
144616011601.046.8746.9Perceptual symbol systems. L W BarsalouBehav Brain Sci199911301525No
144716011601.00.00.0Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. O OuchterlonyActa Pathol Microbiol Scand195313079779Yes
144816011601.033.0433.0The synaptic vesicle cycle. Thomas C SudhofAnnu Rev Neurosci200415217342No
144916011601.042.0842.1Adipose tissue, adipokines, and inflammation. Giamila FantuzziJ Allergy Clin Immunol200515867843No
145016001600.00.00.0Paced auditory serial-addition task: a measure of recovery from concussion. D M GronwallPercept Mot Skills1977866038Yes
145131991599.574.7737.4Issues and challenges facing rechargeable lithium batteries. J M Tarascon, M ArmandNature200111713543Yes
145215991599.036.9637.0VLA proteins in the integrin family: structures, functions, and their role on leukocytes. M E HemlerAnnu Rev Immunol19902188667No
145315991599.00.00.0Structural considerations in the interaction of DNA and acridines. L S LermanJ Mol Biol196113761054Yes
145415991599.045.0145.0Oxidative stress and neurodegeneration: where are we now? Barry HalliwellJ Neurochem200616805774No
145515991599.040.4540.5Angiogenesis: an organizing principle for drug discovery? Judah FolkmanNat Rev Drug Discov200717396134No
145631961598.063.631.8Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. M E Greenberg, E B ZiffNature19846090941Yes
145715981598.039.8839.9Tumor angiogenesis. Robert S KerbelN Engl J Med200818463380No
145831941597.093.146.5Event-related EEG/MEG synchronization and desynchronization: basic principles. G Pfurtscheller, F H Lopes da SilvaClin Neurophysiol199910576479No
145931941597.0106.453.2Understanding interobserver agreement: the kappa statistic. Anthony J Viera, Joanne M GarrettFam Med200515883903Yes
146031901595.097.8448.9Autophagy: renovation of cells and tissues. Noboru Mizushima, Masaaki KomatsuCell201122078875No
146115941594.00.00.0Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. K O FagerströmAddict Behav1978735910Yes
146215941594.068.5968.6The drug abuse screening test. H A SkinnerAddict Behav19827183189Yes
146315941594.053.8353.8Number of people with glaucoma worldwide. H A QuigleyBr J Ophthalmol19968695555No
146431881594.063.2131.6Automated MAD and MIR structure solution. T C Terwilliger, J BerendzenActa Crystallogr D Biol Crystallogr199910089316Yes
146515941594.039.0739.1The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Michael R LieberAnnu Rev Biochem201020192759No
146615931593.032.7932.8Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Judith CampisiCell200515734683No
146747771592.3103.3434.4A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. Zhang, Chung, OldenburgJ Biomol Screen199910838414Yes
146815921592.034.6634.7The caveolae membrane system. R G AndersonAnnu Rev Biochem19989759488No
146915921592.033.6533.6Points of control in inflammation. Carl NathanNature200212490957No
147031831591.5113.9357.0Avoiding false positives with PCR. S Kwok, R HiguchiNature19892716852Yes
147115911591.041.7941.8Alpha-crystallin can function as a molecular chaperone. J HorwitzProc Natl Acad Sci U S A19921438232Yes
147215911591.062.7762.8Modeling and variable selection in epidemiologic analysis. S GreenlandAm J Public Health19892916724Yes
147315911591.061.9762.0Simple proton spectroscopic imaging. W T DixonRadiology19846089263Yes
147463611590.2298.9174.7jModelTest 2: more models, new heuristics and parallel computing. Diego Darriba, Guillermo L Taboada, Ramón Doallo, David PosadaNat Methods201222847109Yes
147515901590.00.00.0Interhemispheric differences in the localization of psychological processes in man. B MilnerBr Med Bull19714937273No
147631801590.082.2741.1Long short-term memory. S Hochreiter, J SchmidhuberNeural Comput19979377276Yes
147715891589.00.00.0The relationship between the spleen colony-forming cell and the haemopoietic stem cell. R SchofieldBlood Cells1978747780Yes
147847671589.0133.3444.4The metabolic syndrome--a new worldwide definition. K George M M Alberti, Paul Zimmet, Jonathan ShawLancet200516182882Yes
147915881588.031.7731.8An analysis of vertebrate mRNA sequences: intimations of translational control. M KozakJ Cell Biol19911955461No
148015881588.039.9239.9Tumor necrosis factor (TNF). L J OldScience19852413547Yes
148115881588.047.4647.5Multiple imputation: a primer. J L SchaferStat Methods Med Res199910347857No
148231761588.00.00.0Convergent and discriminant validation by the multitrait-multimethod matrix. D T Campbell, D W FiskePsychol Bull195913634291Yes
148315871587.00.00.0The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. A G PearseJ Histochem Cytochem19694143745No
148431741587.0116.4358.2ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. M Gardes, T D BrunsMol Ecol19938180733Yes
148547591586.3105.3935.1Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. J E Darnell, I M Kerr, G R StarkScience19948197455No
148615861586.031.8231.8Generating samples under a Wright-Fisher neutral model of genetic variation. Richard R HudsonBioinformatics200211847089Yes
148715851585.042.742.7From sensation to cognition. M M MesulamBrain19989648540No
148831691584.568.2434.1Inhibitors of mammalian G1 cyclin-dependent kinases. C J Sherr, J M RobertsGenes Dev19957758941No
148915841584.039.3739.4Python: a programming language for software integration and development. M F SannerJ Mol Graph Model199910660911Yes
149015831583.045.7145.7Ionic dependence of glutamate neurotoxicity. D W ChoiJ Neurosci19872880938Yes
1491142421582.4515.8957.3STAR: ultrafast universal RNA-seq aligner. Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R GingerasBioinformatics201323104886Yes
149215821582.072.2472.2Mood and memory. G H BowerAm Psychol19817224324Yes
149315821582.046.2546.2Trail Making Test A and B: normative data stratified by age and education. Tom N TombaughArch Clin Neuropsychol200415010086Yes
149415811581.045.2345.2Determination of minimum inhibitory concentrations. J M AndrewsJ Antimicrob Chemother200111420333Yes
149531611580.578.439.2A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. S Tabor, C C RichardsonProc Natl Acad Sci U S A19853156376Yes
149615801580.057.5657.6Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. P HolzerPharmacol Rev19911852779No
149715801580.060.2660.3Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. Lutz AckermannChem Rev201121391562Yes
149831591579.567.1333.6A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. D Wessel, U I FlüggeAnal Biochem19846731838Yes
149915791579.00.00.0Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. B HilleJ Gen Physiol1977300786Yes
150015791579.00.00.0Fluorescence energy transfer as a spectroscopic ruler. L StryerAnnu Rev Biochem1978354506No
150115791579.050.9551.0The stress response in fish. S E Wendelaar BongaPhysiol Rev19979234959No
150231551577.5124.2262.1The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. A J Stunkard, S MessickJ Psychosom Res19853981480Yes
150331531576.595.7147.9Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. M Karas, F HillenkampAnal Chem19883239801Yes
150415761576.034.6834.7On finding all suboptimal foldings of an RNA molecule. M ZukerScience19892468181No
150531521576.088.8444.4Polyamines. C W Tabor, H TaborAnnu Rev Biochem19846206782No
150615761576.040.1940.2Cellular basis of working memory. P S Goldman-RakicNeuron19957695894No
150715761576.030.2530.2Germinal centers. I C MacLennanAnnu Rev Immunol19948011279No
150815761576.055.6855.7Frontal-subcortical circuits and human behavior. J L CummingsArch Neurol19938352676No
150915761576.052.6152.6A new automated colorimetric method for measuring total oxidant status. Ozcan ErelClin Biochem200516214125Yes
151047251575.0190.5863.5The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. C A McHorney, J E Ware, A E RaczekMed Care19938450681Yes
151147251575.0107.1735.7An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J K Eng, A L McCormack, J R YatesJ Am Soc Mass Spectrom199424226387Yes
151215741574.00.00.0Regulation of noradrenaline release by presynaptic receptor systems. K StarkeRev Physiol Biochem Pharmacol197714389No
151331461573.097.748.9Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. D S Bredt, S H SnyderProc Natl Acad Sci U S A19901689048Yes
151415731573.030.8630.9Switching and signaling at the telomere. E H BlackburnCell200111572773No
151531431571.5209.38104.7A clinical method of functional assessment of the shoulder. C R Constant, A H MurleyClin Orthop Relat Res19873791738Yes
151615711571.052.4152.4Biology of interleukin 1. C A DinarelloFASEB J19883277884No
151778551571.0195.7839.2Development and testing of a general amber force field. Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A CaseJ Comput Chem200415116359Yes
1518125571569.6328.741.1Electric field effect in atomically thin carbon films. K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A FirsovScience200415499015Yes
151915691569.052.6752.7Archaea in coastal marine environments. E F DeLongProc Natl Acad Sci U S A19921608980Yes
152015681568.00.00.0Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. W H OldendorfAm J Physiol19715124307Yes
152115681568.049.3249.3Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. F RoussetGenetics19979093870Yes
152231361568.076.3338.2The DNA-damage response in human biology and disease. Stephen P Jackson, Jiri BartekNature200919847258No
152315671567.00.00.0Discharge patterns and functional organization of mammalian retina. S W KufflerJ Neurophysiol195313035466Yes
152446991566.3134.2444.7Cell death: the significance of apoptosis. A H Wyllie, J F Kerr, A R CurrieInt Rev Cytol19807014501No
152515661566.045.4145.4Molecular dissection of reactive astrogliosis and glial scar formation. Michael V SofroniewTrends Neurosci200919782411No
152615651565.035.8135.8The proto-oncogene Bcl-2 and its role in regulating apoptosis. G KroemerNat Med19979176486No
152715651565.00.00.0The estimation of phosphorus. R J AllenBiochem J194016747230Yes
152815641564.051.3651.4Health consequences of obesity in youth: childhood predictors of adult disease. W H DietzPediatrics199812224658No
152915631563.040.5940.6Molecular biology of prion diseases. S B PrusinerScience19911675487No
153062521563.0308.0677.0The Satisfaction With Life Scale. E Diener, R A Emmons, R J Larsen, S GriffinJ Pers Assess198516367493Yes
153115621562.034.3434.3Neuronal calcium signaling. M J BerridgeNeuron19989697848No
153215601560.042.9142.9The complete general secretory pathway in gram-negative bacteria. A P PugsleyMicrobiol Rev19938096622No
153315601560.045.3445.3The in vitro micronucleus technique. M FenechMutat Res200011113469No
153431191559.571.7635.9The epigenomics of cancer. Peter A Jones, Stephen B BaylinCell200717320506No
153546781559.30.00.0Impact of Event Scale: a measure of subjective stress. M Horowitz, N Wilner, W AlvarezPsychosom Med1979472086Yes
153631181559.081.140.5Origins and Mechanisms of miRNAs and siRNAs. Richard W Carthew, Erik J SontheimerCell200919239886No
153715581558.045.4945.5Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. S HakomoriAnnu Rev Biochem19817023369No
153815581558.00.00.0A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. B C HummelCan J Biochem Physiol195914405350Yes
153915571557.038.1638.2The retinal pigment epithelium in visual function. Olaf StraussPhysiol Rev200515987797No
154015571557.060.2160.2Large-scale brain networks and psychopathology: a unifying triple network model. Vinod MenonTrends Cogn Sci201121908230No
154115561556.039.2839.3Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. Z YangJ Mol Evol19947932792Yes
154215561556.050.4150.4Cellular defenses against damage from reactive oxygen species. B P YuPhysiol Rev19948295932No
154315551555.027.727.7Cell cycle checkpoint signaling through the ATM and ATR kinases. R T AbrahamGenes Dev200111544175No
154415541554.045.6145.6The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. R R LlinásScience19883059497No
154515541554.041.8941.9Molecular bases of the acute coronary syndromes. P LibbyCirculation19957758192No
154615541554.036.4136.4AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. D Grahame HardieNat Rev Mol Cell Biol200717712357No
154715531553.041.6141.6Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. D A DoughertyScience19968539615No
154831051552.50.00.0The structure of coping. L I Pearlin, C SchoolerJ Health Soc Behav1978649936Yes
154915521552.00.00.0The inverse care law. J T HartLancet19714100731Yes
155031041552.091.1145.6Oxidative stress, glutamate, and neurodegenerative disorders. J T Coyle, P PuttfarckenScience19937901908No
155115521552.042.3442.3THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. Kozi AsadaAnnu Rev Plant Physiol Plant Mol Biol199915012221Yes
155215511551.060.3460.3Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. P HolzerNeuroscience19883288903No
155346481549.30.00.0A highly sensitive adenylate cyclase assay. Y Salomon, C Londos, M RodbellAnal Biochem19744827395Yes
155446481549.3125.4241.8Median-joining networks for inferring intraspecific phylogenies. H J Bandelt, P Forster, A RöhlMol Biol Evol199910331250Yes
155515491549.051.4751.5Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). M N MarshGastroenterology19921727768No
155615481548.044.8644.9Oxidative stress: oxidants and antioxidants. H SiesExp Physiol19979129943No
155792881548.0287.0547.8Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939837Yes
155815471547.00.00.0Synaptic density in human frontal cortex - developmental changes and effects of aging. P R HuttenlocherBrain Res1979427544Yes
155930941547.0102.1751.1Separate visual pathways for perception and action. M A Goodale, A D MilnerTrends Neurosci19921374953No
156015471547.038.0538.0HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. J M CoffinScience19957824947Yes
156115471547.045.5545.5Porous scaffold design for tissue engineering. Scott J HollisterNat Mater200516003400No
156292811546.8196.3632.7Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C MelloNature19989486653Yes
156392791546.5219.5436.6Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuireScience19873798106Yes
156415451545.039.4939.5Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. M J MeaneyAnnu Rev Neurosci200111520931No
156546351545.0117.839.3Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. Earl S Ford, Wayne H Giles, William H DietzJAMA200211790215Yes
156615451545.046.646.6Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Ralph A DefronzoDiabetes200919336687No
1567169911544.6454.3341.3PLINK: a tool set for whole-genome association and population-based linkage analyses. Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C ShamAm J Hum Genet200717701901Yes
156846321544.0104.0434.7Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. M A Frohman, M K Dush, G R MartinProc Natl Acad Sci U S A19882461560Yes
156961741543.5232.1158.0SignalP 4.0: discriminating signal peptides from transmembrane regions. Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik NielsenNat Methods201121959131Yes
157015431543.039.4339.4Growth of the plant cell wall. Daniel J CosgroveNat Rev Mol Cell Biol200516261190No
157130821541.00.00.0A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. G Schmidt, S J ThannhauserJ Biol Chem194521005717Yes
157215401540.00.00.0Statistical analysis of enzyme kinetic data. W W ClelandMethods Enzymol1979502857Yes
157376981539.6201.9840.4Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan HsuN Engl J Med200415385656Yes
157430791539.568.4334.2Why do cancers have high aerobic glycolysis? Robert A Gatenby, Robert J GilliesNat Rev Cancer200415516961No
157530781539.0160.8780.4Interrater reliability of a modified Ashworth scale of muscle spasticity. R W Bohannon, M B SmithPhys Ther19873809245Yes
157615391539.00.00.0Dithiothreitol, A New Protective Reagent For Sh Groups. W W ClelandBiochemistry196414192894Yes
157715381538.036.0136.0Trastuzumab--mechanism of action and use in clinical practice. Clifford A HudisN Engl J Med200717611206No
157815371537.034.7534.8Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. C TaswellJ Immunol19817009746Yes
157930741537.064.6532.3Upstream and downstream of mTOR. Nissim Hay, Nahum SonenbergGenes Dev200415314020No
158030731536.5101.9951.0Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Stephen M Smith, Thomas E NicholsNeuroimage200918501637Yes
158115361536.028.2228.2Altering the genome by homologous recombination. M R CapecchiScience19892660260No
158215361536.070.9771.0Measurement of health state utilities for economic appraisal. G W TorranceJ Health Econ198610311607No
158392081534.7319.9153.3Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R TannenbaumAnal Biochem19827181105Yes
158430681534.00.00.0Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. C B Lozzio, B B LozzioBlood1975163658Yes
158515341534.070.6170.6The contribution of low birth weight to infant mortality and childhood morbidity. M C McCormickN Engl J Med19853880598No
158615341534.079.0979.1The biology and function of fibroblasts in cancer. Raghu KalluriNat Rev Cancer201627550820No
158715331533.066.7866.8A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. D J SchuirmannJ Pharmacokinet Biopharm19873450848Yes
158815331533.036.5536.5Getting formal with dopamine and reward. Wolfram SchultzNeuron200212383780No
158915331533.00.00.0Antigen-Antibody Crossed Electrophoresis. C B LaurellAnal Biochem196514302464Yes
159030661533.070.5335.3Fibroblasts in cancer. Raghu Kalluri, Michael ZeisbergNat Rev Cancer200616572188No
1591107291532.7505.3872.2limma powers differential expression analyses for RNA-sequencing and microarray studies. Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K SmythNucleic Acids Res201525605792Yes
159230641532.0103.5451.8The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. R Doll, R PetoJ Natl Cancer Inst19817017215No
159315311531.039.0839.1Early signals in the mitogenic response. E RozengurtScience19863018928No
159415311531.044.5744.6Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. A E PeggCancer Res19883123052No
159515311531.069.6369.6Gctf: Real-time CTF determination and correction. Kai ZhangJ Struct Biol201626592709Yes
159615301530.00.00.0Which elements are excited in electrical stimulation of mammalian central nervous system: a review. J B RanckBrain Res19751102064No
159730591529.50.00.0New Giemsa method for the differential staining of sister chromatids. P Perry, S WolffNature19744138930Yes
159815291529.030.7330.7E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. J R NevinsScience19921411535Yes
159915291529.034.3734.4Molecular themes in oncogenesis. J M BishopCell19911988146No
160015291529.030.3430.3Neuroblastoma: biological insights into a clinical enigma. Garrett M BrodeurNat Rev Cancer200312612655No
160115291529.00.00.0Cognitive maps in rats and men. E C TolmanPsychol Rev194818870876Yes
160215281528.00.00.0An enzymic method for the trace iodination of immunoglobulins and other proteins. J J MarchalonisBiochem J19694185494Yes
160330561528.075.0837.5Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Robert Visse, Hideaki NagaseCirc Res200312730128No
160415271527.057.3657.4Aging, natural death, and the compression of morbidity. J F FriesN Engl J Med19807383070Yes
160515261526.031.0631.1Network motifs: theory and experimental approaches. Uri AlonNat Rev Genet200717510665No
160630511525.565.7732.9Signaling to NF-kappaB. Matthew S Hayden, Sankar GhoshGenes Dev200415371334No
160715251525.056.9456.9The linear-quadratic formula and progress in fractionated radiotherapy. J F FowlerBr J Radiol19892670032No
160815251525.045.4745.5Recent advances in the biochemistry of polyamines in eukaryotes. A E PeggBiochem J19863087344No
160915251525.036.636.6Thiazolidinediones. Hannele Yki-JärvinenN Engl J Med200415356308No
161030481524.00.00.0Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. D B Dill, D L CostillJ Appl Physiol19744850854Yes
161115241524.036.5736.6The hippo signaling pathway in development and cancer. Duojia PanDev Cell201020951342No
161230471523.560.4830.2Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. O Tetsu, F McCormickNature199910201372Yes
161330471523.576.1938.1The BCL-2 protein family: opposing activities that mediate cell death. Richard J Youle, Andreas StrasserNat Rev Mol Cell Biol200818097445No
161415231523.00.00.0Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. H S PenefskyJ Biol Chem197716006Yes
161515221522.060.2360.2Probiotics in man and animals. R FullerJ Appl Bacteriol19892666378No
161615221522.044.744.7The basal ganglia: focused selection and inhibition of competing motor programs. J W MinkProg Neurobiol19969004351No
161715221522.029.1729.2How cells read TGF-beta signals. J MassaguéNat Rev Mol Cell Biol200011252892No
161815221522.044.2844.3What we can do and what we cannot do with fMRI. Nikos K LogothetisNature200818548064No
161930421521.096.948.5Alzheimer's disease. Henry W Querfurth, Frank M LaFerlaN Engl J Med201020107219No
162060831520.8137.0434.3MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi MiyataNucleic Acids Res200212136088Yes
162115191519.041.641.6Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. L A LiottaCancer Res19862998604No
162215191519.031.2131.2The ubiquitin-proteasome proteolytic pathway. A CiechanoverCell19947923371No
162315191519.048.0748.1Constructions of masculinity and their influence on men's well-being: a theory of gender and health. W H CourtenaySoc Sci Med200010741575No
162415181518.032.6332.6Oxidative stress shortens telomeres. Thomas von ZglinickiTrends Biochem Sci200212114022Yes
162530351517.50.00.0Computed circular dichroism spectra for the evaluation of protein conformation. N Greenfield, G D FasmanBiochemistry19695346390Yes
162615171517.00.00.0Calcium release from the sarcoplasmic reticulum. M EndoPhysiol Rev197713441Yes
162715161516.030.6130.6The microRNA Registry. Sam Griffiths-JonesNucleic Acids Res200414681370Yes
162815151515.038.7638.8Tricine-SDS-PAGE. Hermann SchäggerNat Protoc200617406207Yes
162915151515.041.4841.5Pathogen recognition and inflammatory signaling in innate immune defenses. Trine H MogensenClin Microbiol Rev200919366914No
163030291514.573.4136.7Human mesenchymal stem cells modulate allogeneic immune cell responses. Sudeepta Aggarwal, Mark F PittengerBlood200515494428Yes
163115141514.00.00.0Biological applications of ionophores. B C PressmanAnnu Rev Biochem1976786156No
163215141514.047.6847.7The role of the amygdala in fear and anxiety. M DavisAnnu Rev Neurosci19921575447No
163315141514.037.437.4Recognition of errors in three-dimensional structures of proteins. M J SipplProteins19938108378Yes
163445421514.0117.9239.3Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Prateek Kumar, Steven Henikoff, Pauline C NgNat Protoc200919561590Yes
163575671513.4174.1634.8Stages of embryonic development of the zebrafish. C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F SchillingDev Dyn19958589427Yes
163615131513.035.6135.6Hypertrophic cardiomyopathy: a systematic review. Barry J MaronJAMA200211886323No
163715131513.036.1236.1Introduction to NF-kappaB: players, pathways, perspectives. T D GilmoreOncogene200617072321No
163830261513.098.8749.4Molecular mechanisms and clinical applications of angiogenesis. Peter Carmeliet, Rakesh K JainNature201121593862No
163960501512.50.00.0The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. S P Baker, B O'Neill, W Haddon, W B LongJ Trauma19744814394Yes
164015121512.00.00.0The recurrence of intracranial meningiomas after surgical treatment. D SimpsonJ Neurol Neurosurg Psychiatry195713406590Yes
164115111511.033.7233.7Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. G L SemenzaAnnu Rev Cell Dev Biol199910611972No
164215101510.00.00.0Some observations upon a new inhibitor of monoamine oxidase in brain tissue. J P JohnstonBiochem Pharmacol19685659776Yes
164315101510.00.00.0Application of a Theory of Enzyme Specificity to Protein Synthesis. D E KoshlandProc Natl Acad Sci U S A195816590179Yes
164430191509.573.8836.9Shared principles in NF-kappaB signaling. Matthew S Hayden, Sankar GhoshCell200818267068No
164515081508.042.3942.4Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Y Ben-AriNeuroscience19852859548No
164615081508.038.3838.4The corticosteroid receptor hypothesis of depression. F HolsboerNeuropsychopharmacology200011027914No
164730151507.592.3346.2Unified approach for molecular dynamics and density-functional theory. Car, ParrinelloPhys Rev Lett198510032153Yes
164830151507.563.2931.6Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Gary L Johnson, Razvan LapadatScience200212471242No
164915071507.038.2238.2Trophic factors and neuronal survival. Y A BardeNeuron19892697237No
165045191506.3155.1551.7A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. J R Le Gall, S Lemeshow, F SaulnierJAMA19938254858Yes
165115061506.036.7436.7A revolution in optical manipulation. David G GrierNature200312917694No
165215041504.053.8353.8Cognitive reserve. Yaakov SternNeuropsychologia200919467352No
165315021502.00.00.0Simple memory: a theory for archicortex. D MarrPhilos Trans R Soc Lond B Biol Sci19714399412Yes
165415011501.00.00.0Cerebral blood flow and oxygen consumption in man. N A LassenPhysiol Rev195913645234Yes
165515011501.046.0246.0Gold-catalyzed organic reactions. A Stephen K HashmiChem Rev200717580975Yes
165615011501.066.3966.4KDIGO clinical practice guidelines for acute kidney injury. Arif KhwajaNephron Clin Pract201222890468No
165714991499.035.0835.1Perceptions of epigenetics. Adrian BirdNature200717522671Yes
165814981498.00.00.0Dopamine (3-hydroxytyramine) and brain function. O HornykiewiczPharmacol Rev19665328389No
165914981498.066.5966.6The emerging role of lncRNAs in cancer. Maite HuarteNat Med201526540387No
166074861497.20.00.0Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. S Katz, A B Ford, R W Moskowitz, B A Jackson, M W JaffeJAMA196314044222Yes
166114971497.00.00.0Bias in analytic research. D L SackettJ Chronic Dis1979447779Yes
166244911497.090.6730.2Efficient selection for high-expression transfectants with a novel eukaryotic vector. H Niwa, K Yamamura, J MiyazakiGene19911660837Yes
166329941497.0109.7554.9The transtheoretical model of health behavior change. J O Prochaska, W F VelicerAm J Health Promot199710170434No
166414951495.00.00.0A soluble protein characteristic of the nervous system. B W MooreBiochem Biophys Res Commun19654953930Yes
166544841494.790.630.2T-Coffee: A novel method for fast and accurate multiple sequence alignment. C Notredame, D G Higgins, J HeringaJ Mol Biol200010964570Yes
166629891494.579.2539.6Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. M A Nitsche, W PaulusJ Physiol200010990547Yes
166714941494.00.00.0Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J C UnkelessJ Exp Med197990108Yes
166814931493.039.4139.4The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. A S FauciScience19883277274No
166914931493.00.00.0Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. C S NeerJ Bone Joint Surg Am19725054450Yes
167044791493.0121.0740.4A neural substrate of prediction and reward. W Schultz, P Dayan, P R MontagueScience19979054347No
167114931493.032.0132.0DNA in a material world. Nadrian C SeemanNature200312540916No
167214931493.052.7752.8Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Berislav V ZlokovicNat Rev Neurosci201122048062No
167344751491.7117.339.1The rapid generation of mutation data matrices from protein sequences. D T Jones, W R Taylor, J M ThorntonComput Appl Biosci19921633570Yes
167414911491.041.941.9Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. A FabiatoAm J Physiol19836346892No
167514911491.031.931.9Neurotrophins and their receptors: a convergence point for many signalling pathways. Moses V ChaoNat Rev Neurosci200312671646No
167644721490.795.8331.9The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. S K Hanks, A M Quinn, T HunterScience19883291115No
167729781489.00.00.0Lactic dehydrogenase activity in blood. F Wroblewski, J S LadueProc Soc Exp Biol Med195513273400Yes
167814881488.00.00.0Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. S AvrameasImmunochemistry19694975324Yes
167914881488.035.4335.4A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. D A GewirtzBiochem Pharmacol199910075079No
168014881488.086.1786.2Deep learning in neural networks: an overview. Jürgen SchmidhuberNeural Netw201525462637No
168114871487.00.00.0Impulses and Physiological States in Theoretical Models of Nerve Membrane. R FitzhughBiophys J196119431309Yes
168214851485.00.00.0Atherogenesis: a postprandial phenomenon. D B ZilversmitCirculation1979222498Yes
168314851485.052.1752.2Lyme disease. A C SteereN Engl J Med19892668764No
168429671483.50.00.0Junctional complexes in various epithelia. M G Farquhar, G E PaladeJ Cell Biol196313944428Yes
168514831483.040.0340.0Precision mapping of quantitative trait loci. Z B ZengGenetics19948013918Yes
168629641482.071.5535.8The incidence of congenital heart disease. Julien I E Hoffman, Samuel KaplanJ Am Coll Cardiol200212084585No
168714811481.080.5380.5Subjective well-being. E DienerPsychol Bull19846399758No
168814811481.062.3262.3Antibiotics in the aquatic environment--a review--part I. Klaus KümmererChemosphere200919185900No
168914801480.033.7133.7Tumor suppressor genes. R A WeinbergScience19911659741No
169014801480.00.00.0Simple methods for "staining with lead" at high pH in electron microscopy. M J KarnovskyJ Biophys Biochem Cytol196114454024Yes
169129591479.5114.1757.1The mini-mental state examination: a comprehensive review. T N Tombaugh, N J McIntyreJ Am Geriatr Soc19921512391No
169229591479.559.629.8Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. P J Mitchell, R TjianScience19892667136No
169314791479.00.00.0The colorimetric determination of phosphorus. E J KingBiochem J193216744823Yes
169414781478.040.0140.0Rheumatoid arthritis. Pathophysiology and implications for therapy. E D HarrisN Engl J Med19902271017No
169544341478.084.9528.3Notch signaling: cell fate control and signal integration in development. S Artavanis-Tsakonas, M D Rand, R J LakeScience199910221902No
169614771477.094.0894.1The antibiotic resistance crisis: part 1: causes and threats. C Lee VentolaP T201525859123Yes
169714761476.00.00.0Isolated removal of hypothalamic or other brain nuclei of the rat. M PalkovitsBrain Res19734747772Yes
169814761476.038.1138.1Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Shitij KapurAm J Psychiatry200312505794No
169959021475.5239.7159.916S ribosomal DNA amplification for phylogenetic study. W G Weisburg, S M Barns, D A Pelletier, D J LaneJ Bacteriol19911987160Yes
170014751475.025.4325.4Neuronal specification in the spinal cord: inductive signals and transcriptional codes. T M JessellNat Rev Genet200011262869No
170129491474.586.843.4The precuneus: a review of its functional anatomy and behavioural correlates. Andrea E Cavanna, Michael R TrimbleBrain200616399806No
170229481474.067.0333.5Complex networks orchestrate epithelial-mesenchymal transitions. Jean Paul Thiery, Jonathan P SleemanNat Rev Mol Cell Biol200616493418No
170314741474.037.6437.6Lead- and drug-like compounds: the rule-of-five revolution. Christopher A LipinskiDrug Discov Today Technol200424981612Yes
170429471473.5104.5452.3Palladium-catalyzed ligand-directed C-H functionalization reactions. Thomas W Lyons, Melanie S SanfordChem Rev201020078038No
170544191473.0151.1750.4Phylogenetic identification and in situ detection of individual microbial cells without cultivation. R I Amann, W Ludwig, K H SchleiferMicrobiol Rev19957535888No
170629451472.560.7330.4NF-kappaB regulation in the immune system. Qiutang Li, Inder M VermaNat Rev Immunol200212360211No
170714721472.049.4349.4Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. H J GundersenJ Microsc19863761363Yes
170814721472.00.00.0Selforganization of matter and the evolution of biological macromolecules. M EigenNaturwissenschaften19714942363No
170914721472.00.00.0The Gingival Index, the Plaque Index and the Retention Index Systems. H LöeJ Periodontol19675237684Yes
171029441472.066.1333.1Cell migration: a physically integrated molecular process. D A Lauffenburger, A F HorwitzCell19968608589No
171129441472.073.8236.9Adipose tissue as an endocrine organ. Erin E Kershaw, Jeffrey S FlierJ Clin Endocrinol Metab200415181022No
171214701470.029.0829.1Intrinsically unstructured proteins. Peter TompaTrends Biochem Sci200212368089No
171314691469.033.7733.8Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. M B LuskinNeuron19938338665Yes
171429371468.50.00.0Diabetes and cardiovascular disease. The Framingham study. W B Kannel, D L McGeeJAMA1979430798Yes
171529371468.582.9741.5Multiple sclerosis. Alastair Compston, Alasdair ColesLancet200818970977Yes
171614681468.042.5342.5Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. P A BradfordClin Microbiol Rev200111585791No
171744021467.3123.0641.0Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. M Hasegawa, H Kishino, T YanoJ Mol Evol19853934395Yes
171829341467.084.0842.0Diarrheagenic Escherichia coli. J P Nataro, J B KaperClin Microbiol Rev19989457432No
171914671467.033.1433.1An approximately unbiased test of phylogenetic tree selection. Hidetoshi ShimodairaSyst Biol200212079646Yes
172014661466.032.1932.2From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. W A CatterallNeuron200010798388No
172114661466.00.00.0Nutrition needs of mammalian cells in tissue culture. H EagleScience195513255879Yes
172214651465.031.7231.7Drug discovery: a historical perspective. J DrewsScience200010720314No
172314651465.034.4834.5PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. Michael F. ThomashowAnnu Rev Plant Physiol Plant Mol Biol199915012220Yes
172443941464.70.00.0The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. J T Dodge, C Mitchell, D J HanahanArch Biochem Biophys196314028302Yes
172529291464.50.00.0A general method for isolation of high molecular weight DNA from eukaryotes. N Blin, D W StaffordNucleic Acids Res1976987581Yes
172614641464.048.8748.9Validation of a decisional conflict scale. A M O'ConnorMed Decis Making19957898294Yes
172714641464.039.839.8Redox signaling: nitrosylation and related target interactions of nitric oxide. J S StamlerCell19947923362No
172814641464.052.952.9Dual-task interference in simple tasks: data and theory. H PashlerPsychol Bull19947972591No
172914631463.029.0829.1Protein kinases--the major drug targets of the twenty-first century? Philip CohenNat Rev Drug Discov200212120282No
173014631463.035.535.5Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). K M FoxLancet200313678872Yes
173114621462.046.8646.9Evidence for a central component of post-injury pain hypersensitivity. C J WoolfNature19836656869Yes
173214621462.00.00.0Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. R W SperryProc Natl Acad Sci U S A196314077501Yes
173343851461.70.00.0Hydroperoxide metabolism in mammalian organs. B Chance, H Sies, A BoverisPhysiol Rev197937532Yes
173414611461.00.00.0The mechanism of muscular contraction. H E HuxleyScience19694181952No
173514611461.040.7440.7Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. J A BeavoPhysiol Rev19957480160No
173614611461.035.935.9In vivo near-infrared fluorescence imaging. John V FrangioniCurr Opin Chem Biol200314580568No
173714611461.029.1329.1Protein degradation and protection against misfolded or damaged proteins. Alfred L GoldbergNature200314685250No
173814601460.00.00.0Amino acid difference formula to help explain protein evolution. R GranthamScience19744843792Yes
173929201460.00.00.0A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. A H Anton, D F SayreJ Pharmacol Exp Ther196214013351Yes
1740145991459.9360.4736.0Multilineage potential of adult human mesenchymal stem cells. M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R MarshakScience199910102814Yes
174158391459.80.00.0A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. M A Markwell, S M Haas, L L Bieber, N E TolbertAnal Biochem197898070Yes
174229191459.556.3528.2The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Michael H Glickman, Aaron CiechanoverPhysiol Rev200211917093No
174358381459.5148.0637.0Improved optimization for the robust and accurate linear registration and motion correction of brain images. Mark Jenkinson, Peter Bannister, Michael Brady, Stephen SmithNeuroimage200212377157Yes
174414591459.037.8737.9Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. B Winkel-ShirleyPlant Physiol200111402179No
174514581458.00.00.0Stimulated acoustic emissions from within the human auditory system. D T KempJ Acoust Soc Am1978744838Yes
174614571457.037.3837.4Type I diabetes mellitus. A chronic autoimmune disease. G S EisenbarthN Engl J Med19863517648No
174714561456.00.00.0Ionic blockage of sodium channels in nerve. A M WoodhullJ Gen Physiol19734541078Yes
174814561456.00.00.0Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. I E BushBiochem J195214915960Yes
174914561456.029.5929.6Immunosuppressive networks in the tumour environment and their therapeutic relevance. Weiping ZouNat Rev Cancer200515776005No
175014561456.053.3553.4Falls in older people: epidemiology, risk factors and strategies for prevention. Laurence Z RubensteinAge Ageing200616926202No
175187321455.3281.6446.9Cancer statistics, 2009. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J ThunCA Cancer J Clin200919474385Yes
175214551455.00.00.0Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. P C NowellCancer Res196014427849Yes
175314541454.00.00.0Defective repair replication of DNA in xeroderma pigmentosum. J E CleaverNature19685655953Yes
175414531453.00.00.0The organization of proteins in the human red blood cell membrane. A review. T L SteckJ Cell Biol19744600883No
175558091452.2171.1642.8Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. B Biswal, F Z Yetkin, V M Haughton, J S HydeMagn Reson Med19958524021Yes
175643561452.0108.6736.2Two-photon laser scanning fluorescence microscopy. W Denk, J H Strickler, W W WebbScience19902321027Yes
175714521452.033.4433.4Mechanisms of bone metastasis. G David RoodmanN Engl J Med200415084698No
175829041452.061.1330.6Toll-like receptor control of the adaptive immune responses. Akiko Iwasaki, Ruslan MedzhitovNat Immunol200415454922No
175929031451.568.4234.2Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. C Auffray, F RougeonEur J Biochem19806772444Yes
176029031451.562.8831.4The Ki-67 protein: from the known and the unknown. T Scholzen, J GerdesJ Cell Physiol200010653597No
176129021451.00.00.0Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. R L Heath, L PackerArch Biochem Biophys19685655425Yes
176229021451.076.6738.3The expanding universe of T-cell subsets: Th1, Th2 and more. T R Mosmann, S SadImmunol Today19968820272No
176314511451.034.3334.3Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. S C ManolagasEndocr Rev200010782361No
176429021451.00.00.0Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. D H Clarke, J CasalsAm J Trop Med Hyg195813571577Yes
176514511451.044.744.7Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). Gunther EysenbachJ Med Internet Res200415471760No
176614501450.043.1443.1Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. M D MainesFASEB J19883290025No
176729001450.057.5528.8Missing pieces in the NF-kappaB puzzle. Sankar Ghosh, Michael KarinCell200211983155No
176829001450.089.4644.7Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. James J Gross, Oliver P JohnJ Pers Soc Psychol200312916575Yes
176914501450.00.00.0The free amino groups of insulin. F SangerBiochem J194516747948Yes
177014501450.050.7750.8Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Joseph J VolpeLancet Neurol200919081519No
177143501450.0149.4349.8Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. Aleksandr V Marenich, Christopher J Cramer, Donald G TruhlarJ Phys Chem B200919366259Yes
177228991449.568.5734.3The human plasma proteome: history, character, and diagnostic prospects. N Leigh Anderson, Norman G AndersonMol Cell Proteomics200212488461No
177314491449.029.3229.3Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. D I SvergunBiophys J199910354416Yes
177414491449.045.5945.6Domino Reactions in Organic Synthesis. Lutz F. TietzeChem Rev199611848746Yes
177514491449.00.00.0Starch gel electrophoresis in a discontinous system of buffers. M D PoulikNature195713493570Yes
177614491449.030.3930.4Regulatory T cells, tumour immunity and immunotherapy. Weiping ZouNat Rev Immunol200616557261No
177757941448.5119.1929.8A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. B M Bolstad, R A Irizarry, M Astrand, T P SpeedBioinformatics200312538238Yes
177828961448.075.8337.9Empirical threshold values for quantitative trait mapping. G A Churchill, R W DoergeGenetics19947851788Yes
177914481448.046.6946.7Social relationships and health. Sheldon CohenAm Psychol200415554821No
178028941447.080.640.3A rapid boiling method for the preparation of bacterial plasmids. D S Holmes, M QuigleyAnal Biochem19816269464Yes
178128941447.055.627.8Mutations affecting segment number and polarity in Drosophila. C Nüsslein-Volhard, E WieschausNature19806776413Yes
178228941447.063.031.5Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. E Krissinel, K HenrickActa Crystallogr D Biol Crystallogr200415572779Yes
178314471447.056.2756.3Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. Virginia A MoyerAnn Intern Med201222801674No
178414461446.035.1235.1Neurovascular regulation in the normal brain and in Alzheimer's disease. Costantino IadecolaNat Rev Neurosci200415100718No
178514461446.063.9864.0Pro-resolving lipid mediators are leads for resolution physiology. Charles N SerhanNature201424899309No
178628911445.579.7639.9Angiogenesis. J Folkman, Y ShingJ Biol Chem19921375931No
178714451445.00.00.0Superoxide dismutases. I FridovichAnnu Rev Biochem19751094908No
178828901445.081.7240.9Dali server: conservation mapping in 3D. Liisa Holm, Päivi RosenströmNucleic Acids Res201020457744Yes
178957791444.80.00.0The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. L A Sternberger, P H Hardy, J J Cuculis, H G MeyerJ Histochem Cytochem19704192899Yes
179014441444.048.6148.6Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. G A McPhersonJ Pharmacol Methods19853840547Yes
179128881444.086.3243.2An information-maximization approach to blind separation and blind deconvolution. A J Bell, T J SejnowskiNeural Comput19957584893Yes
179228881444.060.730.4The Bcl2 family: regulators of the cellular life-or-death switch. Suzanne Cory, Jerry M AdamsNat Rev Cancer200212209154No
179357751443.80.00.0A rating scale for mania: reliability, validity and sensitivity. R C Young, J T Biggs, V E Ziegler, D A MeyerBr J Psychiatry1978728692Yes
179428871443.555.7727.9Cellular motility driven by assembly and disassembly of actin filaments. Thomas D Pollard, Gary G BorisyCell200312600310No
179557721443.0249.6662.4An inventory for measuring clinical anxiety: psychometric properties. A T Beck, N Epstein, G Brown, R A SteerJ Consult Clin Psychol19883204199Yes
179614431443.030.4330.4Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. R K JainNat Med200111533692No
179728851442.50.00.0Assay of proteins in the presence of interfering materials. A Bensadoun, D WeinsteinAnal Biochem19761259145Yes
179814421442.033.8933.9Pathogenesis of group A streptococcal infections. M W CunninghamClin Microbiol Rev200010885988No
179914421442.044.5844.6Systemic lupus erythematosus. George C TsokosN Engl J Med201122129255No
180028831441.50.00.0Mutants of Escherichia coli requiring methionine or vitamin B12. B D Davis, E S MingioliJ Bacteriol195015436457Yes
180114401440.034.3634.4Binary Agrobacterium vectors for plant transformation. M BevanNucleic Acids Res19846095209Yes
180214401440.046.4946.5The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. G R BuettnerArch Biochem Biophys19938434935No
180343201440.0126.8242.3Regularization Paths for Generalized Linear Models via Coordinate Descent. Jerome Friedman, Trevor Hastie, Rob TibshiraniJ Stat Softw201020808728Yes
180428791439.50.00.03' non-coding region sequences in eukaryotic messenger RNA. N J Proudfoot, G G BrownleeNature1976822353Yes
180514391439.052.8752.9The case-crossover design: a method for studying transient effects on the risk of acute events. M MaclureAm J Epidemiol19911985444Yes
180614391439.00.00.0Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. J W OlneyScience19695778021Yes
180714391439.00.00.0Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. H E HuxleyJ Mol Biol196314064165Yes
180814391439.036.8436.8The biology of incretin hormones. Daniel J DruckerCell Metab200616517403No
180928781439.0102.6651.3Neurocircuitry of addiction. George F Koob, Nora D VolkowNeuropsychopharmacology201019710631No
181028781439.0111.8255.9Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. Sarvajeet Singh Gill, Narendra TutejaPlant Physiol Biochem201020870416No
181157531438.2168.0242.0Comorbidity measures for use with administrative data. A Elixhauser, C Steiner, D R Harris, R M CoffeyMed Care19989431328Yes
1812129421438.0404.7445.0The 1982 revised criteria for the classification of systemic lupus erythematosus. E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J WinchesterArthritis Rheum19827138600Yes
181314381438.066.6966.7The structure and properties of the sense of coherence scale. A AntonovskySoc Sci Med19938480217Yes
181414381438.036.236.2Insulin and insulin-like growth factor signalling in neoplasia. Michael PollakNat Rev Cancer200819029956No
181543131437.7139.1546.4Estimating the mean and variance from the median, range, and the size of a sample. Stela Pudar Hozo, Benjamin Djulbegovic, Iztok HozoBMC Med Res Methodol200515840177Yes
181614371437.060.0960.1Responses to depression and their effects on the duration of depressive episodes. S Nolen-HoeksemaJ Abnorm Psychol19911757671No
181714371437.037.6837.7Capacitative calcium entry revisited. J W PutneyCell Calcium19901965707No
181828741437.091.5845.8Mechanisms of salinity tolerance. Rana Munns, Mark TesterAnnu Rev Plant Biol200818444910No
181914361436.038.6638.7Integration, scaling, space-group assignment and post-refinement. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124693Yes
182014351435.045.6745.7Polycystic ovary syndrome. S FranksN Engl J Med19957651477No
182114341434.025.8725.9Histone acetylation and transcriptional regulatory mechanisms. K StruhlGenes Dev19989499396No
182228671433.5105.9853.0Pain assessment: global use of the Brief Pain Inventory. C S Cleeland, K M RyanAnn Acad Med Singap19948080219No
182314321432.00.00.0Modality and topographic properties of single neurons of cat's somatic sensory cortex. V B MountcastleJ Neurophysiol195713439410Yes
182414311431.033.0533.0The NCI60 human tumour cell line anticancer drug screen. Robert H ShoemakerNat Rev Cancer200616990858No
182528601430.084.3642.2EQ-5D: a measure of health status from the EuroQol Group. R Rabin, F de CharroAnn Med200111491192No
182642901430.00.00.0Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. C A Winter, E A Risley, G W NussProc Soc Exp Biol Med196214001233Yes
182728571428.559.5329.8Chemokines: a new classification system and their role in immunity. A Zlotnik, O YoshieImmunity200010714678No
182814281428.033.7333.7Developmental cell death: morphological diversity and multiple mechanisms. P G ClarkeAnat Embryol (Berl)19902186664No
182928561428.078.2539.1Early identification of refractory epilepsy. P Kwan, M J BrodieN Engl J Med200010660394Yes
183014281428.027.3727.4Aggresomes, inclusion bodies and protein aggregation. R R KopitoTrends Cell Biol200011121744No
183128541427.067.0633.5A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. L Buck, R AxelCell19911840504Yes
183214271427.00.00.0A clinical method for assessing the ventilatory response to carbon dioxide. D J ReadAustralas Ann Med19676032026Yes
183314271427.044.4944.5Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. L BravoNutr Rev19989838798No
183414271427.00.00.0A modified ninhydrin colorimetric analysis for amino acids. H RosenArch Biochem Biophys195713412116Yes
183514261426.00.00.0Stability of proteins: small globular proteins. P L PrivalovAdv Protein Chem197944431No
183614261426.041.5341.5Glycobiology: Toward Understanding the Function of Sugars. Raymond A. DwekChem Rev199611848770Yes
183714261426.038.838.8External validity of randomised controlled trials: "to whom do the results of this trial apply?". Peter M RothwellLancet200515639683Yes
183871261425.2149.0129.8Prospective identification of tumorigenic breast cancer cells. Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F ClarkeProc Natl Acad Sci U S A200312629218Yes
183914251425.035.5135.5General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. R A HoughtenProc Natl Acad Sci U S A19852410914Yes
184014251425.034.1234.1PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. B M SpiegelmanDiabetes19989568680No
184114241424.00.00.0The genetical evolution of social behaviour. II. W D HamiltonJ Theor Biol19645875340Yes
184214231423.00.00.0Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. M P BlausteinAm J Physiol1977324293No
184314231423.053.2953.3Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. Peter C AustinPharm Stat201120925139Yes
184414211421.044.044.0Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. James J P StewartJ Mol Model200717828561Yes
184528411420.5123.5761.8Deciphering key features in protein structures with the new ENDscript server. Xavier Robert, Patrice GouetNucleic Acids Res201424753421Yes
184628401420.093.6846.8Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. G R Gibson, M B RoberfroidJ Nutr19957782892No
184714201420.059.759.7Adverse health effects of high-effort/low-reward conditions. J SiegristJ Occup Health Psychol19969547031No
184814201420.035.0135.0The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. H MaedaAdv Enzyme Regul200111384745No
184928351417.565.4932.7How matrix metalloproteinases regulate cell behavior. M D Sternlicht, Z WerbAnnu Rev Cell Dev Biol200111687497No
185014171417.00.00.0The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. O V BatsonAnn Surg194017857618Yes
185114161416.037.337.3Aspergillus fumigatus and aspergillosis. J P LatgéClin Microbiol Rev199910194462No
185214161416.041.2241.2n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Philip C CalderAm J Clin Nutr200616841861No
185342411413.7180.3860.1Molecular mechanisms of epithelial-mesenchymal transition. Samy Lamouille, Jian Xu, Rik DerynckNat Rev Mol Cell Biol201424556840No
185428271413.5105.9653.0The need to belong: desire for interpersonal attachments as a fundamental human motivation. R F Baumeister, M R LearyPsychol Bull19957777651No
185528271413.571.6135.8Steatohepatitis: a tale of two "hits"? C P Day, O F JamesGastroenterology19989547102No
185628261413.066.6933.3The MAPK signaling cascade. R Seger, E G KrebsFASEB J19957601337No
185728251412.573.336.6Malignant gliomas in adults. Patrick Y Wen, Santosh KesariN Engl J Med200818669428No
185828241412.0116.7858.4Regulation of microRNA biogenesis. Minju Ha, V Narry KimNat Rev Mol Cell Biol201425027649No
185928231411.564.4932.2Microtubules as a target for anticancer drugs. Mary Ann Jordan, Leslie WilsonNat Rev Cancer200415057285No
186028221411.00.00.0A scaled version of the General Health Questionnaire. D P Goldberg, V F HillierPsychol Med1979424481Yes
186114111411.042.7842.8Semiempirical hybrid density functional with perturbative second-order correlation. Stefan GrimmeJ Chem Phys200616438568Yes
186256431410.8170.5342.6The validity of the Hospital Anxiety and Depression Scale. An updated literature review. Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag NeckelmannJ Psychosom Res200211832252No
186314101410.067.5267.5What's in a name? Qualitative description revisited. Margarete SandelowskiRes Nurs Health201020014004Yes
186442291409.793.2831.1NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. S Ghosh, M J May, E B KoppAnnu Rev Immunol19989597130No
186584571409.5283.247.2New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier GascuelSyst Biol201020525638Yes
186628181409.083.0841.5Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Sally S Dickerson, Margaret E KemenyPsychol Bull200415122924Yes
186728181409.090.8145.4Density functionals with broad applicability in chemistry. Yan Zhao, Donald G TruhlarAcc Chem Res200818186612Yes
186828161408.063.7831.9Raster3D Version 2.0. A program for photorealistic molecular graphics. E A Merritt, M E MurphyActa Crystallogr D Biol Crystallogr199415299354Yes
186928151407.563.7331.9Neurotrophins: roles in neuronal development and function. E J Huang, L F ReichardtAnnu Rev Neurosci200111520916No
187014071407.032.9533.0The molecular logic of endocannabinoid signalling. Daniele PiomelliNat Rev Neurosci200314595399No
187142201406.7121.8240.6The fusiform face area: a module in human extrastriate cortex specialized for face perception. N Kanwisher, J McDermott, M M ChunJ Neurosci19979151747Yes
187242201406.7111.5737.2Optimization by simulated annealing. S Kirkpatrick, C D Gelatt, M P VecchiScience198317813860Yes
187314061406.00.00.0R factor transfer in Rhizobium leguminosarum. J E BeringerJ Gen Microbiol19744612098Yes
187414061406.033.133.1Far-field optical nanoscopy. Stefan W HellScience200717525330No
187528111405.560.1630.1Development by self-digestion: molecular mechanisms and biological functions of autophagy. Beth Levine, Daniel J KlionskyDev Cell200415068787No
187628101405.073.4836.7Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. I Issemann, S GreenNature19902129546Yes
187728091404.568.5234.3Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. F Q Schafer, G R BuettnerFree Radic Biol Med200111368918No
187814041404.043.7443.7The many roles for fluorine in medicinal chemistry. William K HagmannJ Med Chem200818570365Yes
187928071403.50.00.0Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. H J Bloom, W W RichardsonBr J Cancer195713499785Yes
188028061403.085.5942.8The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. J D Hayes, D J PulfordCrit Rev Biochem Mol Biol19958770536No
188114031403.027.4427.4Vienna RNA secondary structure server. Ivo L HofackerNucleic Acids Res200312824340Yes
188228061403.00.00.0Microdetermination of long-chain fatty acids in plasma and tissues. V P Dole, H MeinertzJ Biol Chem196013817286Yes
188314031403.00.00.0Note on the sampling error of the difference between correlated proportions or percentages. Q McNEMARPsychometrika194720254758Yes
188428051402.5112.6956.3Assessment of eating disorders: interview or self-report questionnaire? C G Fairburn, S J BeglinInt J Eat Disord19947866415Yes
188528051402.5100.5550.3The Oswestry Disability Index. J C Fairbank, P B PynsentSpine (Phila Pa 1976)200011074683No
188642071402.3144.9548.3Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Helga Thorvaldsdóttir, James T Robinson, Jill P MesirovBrief Bioinform201322517427Yes
188728041402.059.1929.6Fitting a mixture model by expectation maximization to discover motifs in biopolymers. T L Bailey, C ElkanProc Int Conf Intell Syst Mol Biol19947584402Yes
188828031401.5100.9950.5Saliency, switching, attention and control: a network model of insula function. Vinod Menon, Lucina Q UddinBrain Struct Funct201020512370No
188914011401.073.2573.2Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. F E ZajacCrit Rev Biomed Eng19892676342No
189028011400.50.00.0The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. J O'Keefe, J DostrovskyBrain Res19715124915Yes
189128011400.560.3430.2Coordination of circadian timing in mammals. Steven M Reppert, David R WeaverNature200212198538No
189214001400.00.00.0Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. C A BarnesJ Comp Physiol Psychol1979221551Yes
189314001400.00.00.0The measurement of psychological androgyny. S L BemJ Consult Clin Psychol19744823550Yes
189414001400.00.00.0Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. J WymanAdv Protein Chem196414268785No
189527991399.50.00.0The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. E G Gray, V P WhittakerJ Anat196213901297Yes
189669961399.2152.7830.6Site-directed mutagenesis by overlap extension using the polymerase chain reaction. S N Ho, H D Hunt, R M Horton, J K Pullen, L R PeaseGene19892744487Yes
189713991399.00.00.0Human cardiovascular adjustments to exercise and thermal stress. L B RowellPhysiol Rev19744587247No
189827961398.00.00.0Empirical predictions of protein conformation. P Y Chou, G D FasmanAnnu Rev Biochem1978354496No
189913981398.035.435.4Myeloperoxidase: friend and foe. Seymour J KlebanoffJ Leukoc Biol200515689384No
190013981398.034.9635.0Five rules for the evolution of cooperation. Martin A NowakScience200617158317No
190113981398.035.7835.8The failing heart--an engine out of fuel. Stefan NeubauerN Engl J Med200717360992No
190227951397.5116.058.0Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. A Y Finlay, G K KhanClin Exp Dermatol19948033378Yes
190313971397.00.00.0Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. K S McCullyAm J Pathol19695792556Yes
190413961396.045.4745.5Efficient analysis of experimental observations. W J DixonAnnu Rev Pharmacol Toxicol19807387124Yes
190513961396.031.9431.9Tumor metastasis: mechanistic insights and clinical challenges. Patricia S SteegNat Med200616892035No
190613961396.049.049.0The polyvagal perspective. Stephen W PorgesBiol Psychol200717049418No
190727911395.593.0246.5The efficiency of systematic sampling in stereology and its prediction. H J Gundersen, E B JensenJ Microsc19873430576Yes
190827901395.085.9243.0Intracellular pH. A Roos, W F BoronPhysiol Rev19817012859No
190913941394.057.2957.3A structured interview guide for the Hamilton Depression Rating Scale. J B WilliamsArch Gen Psychiatry19883395203Yes
191013941394.033.9634.0Two pathogenetic types of endometrial carcinoma. J V BokhmanGynecol Oncol19836822361Yes
191113941394.031.1731.2Protein misfolding, evolution and disease. C M DobsonTrends Biochem Sci199910470028No
191213941394.038.2838.3Task switching. Stephen MonsellTrends Cogn Sci200312639695Yes
191313941394.029.1229.1RNA silencing in plants. David BaulcombeNature200415372043No
191427881394.00.00.0Brain stem reticular formation and activation of the EEG. G Moruzzi, H W MagounElectroencephalogr Clin Neurophysiol194918421835Yes
191513931393.033.1633.2Functions of ceramide in coordinating cellular responses to stress. Y A HannunScience19968943189No
191627851392.50.00.0Mutations of Bacteria from Virus Sensitivity to Virus Resistance. S E Luria, M DelbrückGenetics194317247100Yes
191755661391.5126.2631.6Probability-based protein identification by searching sequence databases using mass spectrometry data. D N Perkins, D J Pappin, D M Creasy, J S CottrellElectrophoresis199910612281Yes
191827821391.089.1744.6Functional architecture of basal ganglia circuits: neural substrates of parallel processing. G E Alexander, M D CrutcherTrends Neurosci19901695401No
191913911391.032.8832.9Speculations on the functions of the major heat shock and glucose-regulated proteins. H R PelhamCell19862944601Yes
192013911391.040.4140.4Isolation and cultivation of Lyme disease spirochetes. A G BarbourYale J Biol Med19846393604Yes
192127821391.064.832.4Lipopolysaccharide endotoxins. Christian R H Raetz, Chris WhitfieldAnnu Rev Biochem200212045108No
192241721390.7142.3547.4Vascular endothelial cells synthesize nitric oxide from L-arginine. R M Palmer, D S Ashton, S MoncadaNature19883131684Yes
192313901390.032.0432.0The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. M TakeichiDevelopment19883048970No
192413901390.026.7426.7Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. M G GustafssonJ Microsc200010810003Yes
192513901390.00.00.0Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. W C SchneiderJ Biol Chem194818886166Yes
192613891389.00.00.0Microbial ecology of the gastrointestinal tract. D C SavageAnnu Rev Microbiol1977334036No
192713891389.031.5831.6Cancer epigenomics: DNA methylomes and histone-modification maps. Manel EstellerNat Rev Genet200717339880No
192855541388.5237.7959.4Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanInt J Surg201020171303No
192941651388.3104.0634.7Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck ØrntoftCancer Res200415289330Yes
193027761388.00.00.0A method of trace iodination of proteins for immunologic studies. P J McConahey, F J DixonInt Arch Allergy Appl Immunol19664160044Yes
193113871387.026.5726.6Ubiquitin-dependent protein degradation. M HochstrasserAnnu Rev Genet19968982460No
193213871387.032.2232.2Hematopoietic stem-cell transplantation. Edward A CopelanN Engl J Med200616641398No
193313871387.042.5942.6Surface plasmon resonance sensors for detection of chemical and biological species. Jirí HomolaChem Rev200818229953No
193427731386.562.3131.2An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. A A Beg, D BaltimoreScience19968864118Yes
193513861386.00.00.0Selection of successive tumour lines for metastasis. I J FidlerNat New Biol19734512654Yes
193613861386.039.9540.0Leishmaniasis: current situation and new perspectives. P DesjeuxComp Immunol Microbiol Infect Dis200415225981No
193727711385.572.0436.0A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. J Messing, J VieiraGene19826295880Yes
193827711385.563.4531.7Cancer metastasis: building a framework. Gaorav P Gupta, Joan MassaguéCell200617110329No
193913851385.092.4692.5The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. F C EwaldClin Orthop Relat Res19892805502Yes
194013851385.037.7537.8A more meaningful scoring system for determining the severity of coronary heart disease. G G GensiniAm J Cardiol19836823874Yes
194127681384.071.0235.5CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. D G Higgins, P M SharpGene19883243435Yes
194213841384.030.2130.2Neurotrophins as synaptic modulators. M M PooNat Rev Neurosci200111253356No
194327661383.085.0242.5Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. P J Basser, C PierpaoliJ Magn Reson B19968661285Yes
194413831383.035.4335.4An economic method for the fluorescent labeling of PCR fragments. M SchuelkeNat Biotechnol200010657137Yes
194527651382.573.3936.7Obesity. David W Haslam, W Philip T JamesLancet200516198769No
194696741382.0215.0230.7Embryonic stem cell lines derived from human blastocysts. J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M JonesScience19989804556Yes
194713821382.032.4532.5Ordered porous materials for emerging applications. Mark E DavisNature200212075343No
194813821382.00.00.0Cerebral vascular accidents in patients over the age of 60. II. Prognosis. J RankinScott Med J195713432835Yes
194913821382.00.00.0Potential, Impedance, And Rectification In Membranes. D E GoldmanJ Gen Physiol194319873371Yes
195013811381.00.00.0Codon--anticodon pairing: the wobble hypothesis. F H CrickJ Mol Biol19665969078Yes
195113811381.039.0439.0A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. J EngelEpilepsia200111422340Yes
195227591379.5169.2384.6Rating systems in the evaluation of knee ligament injuries. Y Tegner, J LysholmClin Orthop Relat Res19854028566Yes
195327591379.50.00.0Prediction of protein conformation. P Y Chou, G D FasmanBiochemistry19744358940Yes
195413791379.037.2737.3Cell and environment interactions in tumor microregions: the multicell spheroid model. R M SutherlandScience19882451290Yes
195513771377.035.4435.4Stress and hippocampal plasticity. B S McEwenAnnu Rev Neurosci199910202533No
195627531376.555.027.5The evolutionary fate and consequences of duplicate genes. M Lynch, J S ConeryScience200011073452No
195727521376.063.6431.8NF-kappaB: a key role in inflammatory diseases. P P Tak, G S FiresteinJ Clin Invest200111134171No
195813761376.029.2629.3Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. S S FergusonPharmacol Rev200111171937No
195913751375.036.5636.6Use and misuse of the receiver operating characteristic curve in risk prediction. Nancy R CookCirculation200717309939Yes
196027491374.574.4837.2Macrophage diversity enhances tumor progression and metastasis. Bin-Zhi Qian, Jeffrey W PollardCell201020371344No
196113741374.031.8731.9Protein kinase C: structure, function, and regulation. A C NewtonJ Biol Chem19957499357No
196213741374.026.4626.5NK cell receptors. L L LanierAnnu Rev Immunol19989597134No
196313741374.033.7633.8Neuronal synchrony: a versatile code for the definition of relations? W SingerNeuron199910677026No
196413741374.049.3449.3Matching methods for causal inference: A review and a look forward. Elizabeth A StuartStat Sci201020871802Yes
196527471373.577.5838.8Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. B R Celli, W MacNeeEur Respir J200415219010No
196627471373.50.00.0The effect of sodium ions on the electrical activity of giant axon of the squid. A L Hodgkin, B KatzJ Physiol194918128147Yes
196768661373.2298.2559.6UCHIME improves sensitivity and speed of chimera detection. Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob KnightBioinformatics201121700674Yes
196813731373.033.3233.3The basic science of gene therapy. R C MulliganScience19938493530No
196913731373.00.00.0An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. O SmithiesBiochem J195913638269Yes
197027451372.553.5626.8T-cell antigen receptor genes and T-cell recognition. M M Davis, P J BjorkmanNature19883043226No
197113721372.00.00.0Effects of varying the vehicle for OsO4 in tissue fixation. J B CaulfieldJ Biophys Biochem Cytol195713475399Yes
197213721372.045.2945.3Stress signalling pathways that impair prefrontal cortex structure and function. Amy F T ArnstenNat Rev Neurosci200919455173No
197327421371.00.00.0Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. A J Berk, P A SharpCell1977922889Yes
197413711371.054.5954.6Cardiac valve surgery--the "French correction". A CarpentierJ Thorac Cardiovasc Surg19836887954Yes
197527421371.076.5938.3Transforming growth factor beta in tissue fibrosis. W A Border, N A NobleN Engl J Med19947935686No
197641131371.097.6532.6Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Hartmuth C. Kolb, M. G. Finn, K. Barry SharplessAngew Chem Int Ed Engl200111433435Yes
197741131371.088.8229.6Toll-like receptors. Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo AkiraAnnu Rev Immunol200312524386No
197827421371.00.00.0Immunoassay of endogenous plasma insulin in man. R S Yalow, S A BersonJ Clin Invest196013846364Yes
197913701370.034.4234.4The use of nanocrystals in biological detection. Paul AlivisatosNat Biotechnol200414704706Yes
198041091369.791.5330.5Telomeres shorten during ageing of human fibroblasts. C B Harley, A B Futcher, C W GreiderNature19902342578Yes
198113691369.00.00.0Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. S S LehrerBiochemistry19715119250Yes
198227381369.070.9635.5Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. D Marion, K WüthrichBiochem Biophys Res Commun19836307308Yes
198313691369.029.2429.2The Buccaneer software for automated model building. 1. Tracing protein chains. Kevin CowtanActa Crystallogr D Biol Crystallogr200616929101Yes
198427371368.582.641.3Glycine potentiates the NMDA response in cultured mouse brain neurons. J W Johnson, P AscherNature19872433595Yes
198513681368.045.8545.9Interleukin-1. C A DinarelloRev Infect Dis19846369481No
198613681368.036.4736.5Hydrogels for biomedical applications. Allan S HoffmanAdv Drug Deliv Rev200211755703No
198741041368.091.7730.6TOR signaling in growth and metabolism. Stephan Wullschleger, Robbie Loewith, Michael N HallCell200616469695No
198813671367.043.8343.8Equipoise and the ethics of clinical research. B FreedmanN Engl J Med19873600702Yes
198913671367.028.0128.0Macromolecular crowding: obvious but underappreciated. R J EllisTrends Biochem Sci200111590012No
199054681367.0311.3977.8IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang MinhMol Biol Evol201525371430Yes
199113661366.040.7640.8The aging process. D HarmanProc Natl Acad Sci U S A19816947277Yes
199227311365.599.8749.9Biology of disease: free radicals and tissue injury. B A Freeman, J D CrapoLab Invest19826290784No
199327301365.069.7634.9Unravelling the pathogenesis of inflammatory bowel disease. R J Xavier, D K PodolskyNature200717653185No
199427261363.088.9544.5Unidentified curved bacilli on gastric epithelium in active chronic gastritis. J R Warren, B MarshallLancet19836134060Yes
199513621362.030.6130.6Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. M KozakMicrobiol Rev19836343825No
199613621362.056.5356.5Sample size in qualitative research. M SandelowskiRes Nurs Health19957899572Yes
199727231361.561.730.9Self-assembly at all scales. George M Whitesides, Bartosz GrzybowskiScience200211923529Yes
199813611361.047.9347.9Multiple calcium channels and neuronal function. R J MillerScience19872432656No
199927201360.086.243.1Performing the exact test of Hardy-Weinberg proportion for multiple alleles. S W Guo, E A ThompsonBiometrics19921637966Yes
200013601360.033.4833.5Oxidative stress in Parkinson's disease. Peter JennerAnn Neurol200312666096No
200127191359.584.2242.1From best evidence to best practice: effective implementation of change in patients' care. Richard Grol, Jeremy GrimshawLancet200314568747No
200227171358.567.9734.0Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. E S Lander, D BotsteinGenetics19892563713Yes
200340751358.30.00.0Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Garnier, D J Osguthorpe, B RobsonJ Mol Biol1978642007Yes
200427161358.066.4633.2Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. H Cai, D G HarrisonCirc Res200011073878No
200513581358.032.7432.7Neurotrophin-regulated signalling pathways. Louis F ReichardtPhilos Trans R Soc Lond B Biol Sci200616939974No
200613571357.00.00.0Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. T SpectorAnal Biochem1978655375Yes
200727141357.00.00.0A protein sequenator. P Edman, G BeggEur J Biochem19676059350Yes
200813561356.049.0549.0Colorimetric determination of phospholipids with ammonium ferrothiocyanate. J C StewartAnal Biochem19806892980Yes
200927111355.584.2842.1Protective and pathogenic functions of macrophage subsets. Peter J Murray, Thomas A WynnNat Rev Immunol201121997792No
201013541354.036.9937.0The world health report 2002 - reducing risks, promoting healthy life. J J GuilbertEduc Health (Abingdon)200314741909Yes
201113541354.048.5848.6The global impact of pre-eclampsia and eclampsia. Lelia DuleySemin Perinatol200919464502No
201227061353.00.00.0Peptidoglycan types of bacterial cell walls and their taxonomic implications. K H Schleifer, O KandlerBacteriol Rev19724568761No
201313521352.00.00.0Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. J R DavidProc Natl Acad Sci U S A19665229858Yes
201413511351.025.3825.4The DNA methyltransferases of mammals. T H BestorHum Mol Genet200011005794No
201554011350.2144.1936.0Most mammalian mRNAs are conserved targets of microRNAs. Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P BartelGenome Res200918955434Yes
201640491349.70.00.0Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. D D Sabatini, K Bensch, R J BarrnettJ Cell Biol196313975866Yes
201713491349.034.9635.0The amygdala modulates the consolidation of memories of emotionally arousing experiences. James L McGaughAnnu Rev Neurosci200415217324No
201813481348.045.5945.6Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. N KriegerAm J Public Health19921566949Yes
201926941347.00.00.0Selective loss of central cholinergic neurons in Alzheimer's disease. P Davies, A J MaloneyLancet197663862Yes
202026941347.077.4638.7Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. F D Lublin, S C ReingoldNeurology19968780061Yes
2021175061346.6486.3437.4Clustal W and Clustal X version 2.0. M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G HigginsBioinformatics200717846036Yes
202226921346.00.00.0Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. A Dahlstroem, K FuxeActa Physiol Scand Suppl196414229500Yes
202326911345.50.00.0Synchronization of Plasmodium falciparum erythrocytic stages in culture. C Lambros, J P VanderbergJ Parasitol1979383936Yes
202413451345.00.00.0Stereological principles for morphometry in electron microscopic cytology. E R WeibelInt Rev Cytol19694899604No
202526901345.068.0934.0Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. M D Pierschbacher, E RuoslahtiNature19846325925Yes
202613441344.00.00.0Immunological function of the thymus. J F MillerLancet196114474038Yes
202713441344.00.00.0A modified procedure for lead staining of thin sections. G MillonigJ Biophys Biochem Cytol196114474176Yes
202813431343.00.00.0Blood gas calculator. J W SeveringhausJ Appl Physiol19665912737Yes
202913431343.031.1531.1The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. S E KahnDiabetologia200312637977No
203026861343.057.2528.6A guided tour into subcellular colocalization analysis in light microscopy. S Bolte, F P CordelièresJ Microsc200617210054Yes
203126851342.577.8538.9Mortality by cause for eight regions of the world: Global Burden of Disease Study. C J Murray, A D LopezLancet19979142060Yes
203226841342.00.00.0The respiratory chain and oxidative phosphorylation. B Chance, G R WilliamsAdv Enzymol Relat Subj Biochem195613313307Yes
203326821341.056.5128.3Intrinsically unstructured proteins and their functions. H Jane Dyson, Peter E WrightNat Rev Mol Cell Biol200515738986No
203413401340.032.932.9Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. G von HeijneJ Mol Biol19921593632Yes
203513401340.047.7147.7The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. E J KhantzianHarv Rev Psychiatry19979385000No
203626791339.50.00.0Further improvements in the plaque technique for detecting single antibody-forming cells. A J Cunningham, A SzenbergImmunology19685653817Yes
203726791339.583.8741.9A perspective on cancer cell metastasis. Christine L Chaffer, Robert A WeinbergScience201121436443No
203826781339.062.9831.5NF-kappa B: ten years after. P A Baeuerle, D BaltimoreCell19968858144No
203926781339.054.5827.3Cancer genes and the pathways they control. Bert Vogelstein, Kenneth W KinzlerNat Med200415286780No
204026771338.50.00.0Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. G J Miller, N E MillerLancet197546338Yes
204153511337.80.00.0Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. D W Cleveland, S G Fischer, M W Kirschner, U K LaemmliJ Biol Chem1977320200Yes
204240131337.791.730.6Osteoclast differentiation and activation. William J Boyle, W Scott Simonet, David L LaceyNature200312748652No
204326751337.568.9434.5Molecular beacons: probes that fluoresce upon hybridization. S Tyagi, F R KramerNat Biotechnol19969630890Yes
204413371337.031.231.2Hyaluronan: from extracellular glue to pericellular cue. Bryan P TooleNat Rev Cancer200415229478No
204513361336.050.5250.5UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. D W RussellJ Pers Assess19968576833Yes
204613361336.00.00.0Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. K FuxeActa Physiol Scand Suppl196514319769Yes
204713361336.057.4457.4Cognitive reserve in ageing and Alzheimer's disease. Yaakov SternLancet Neurol201223079557No
204826711335.50.00.0Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. E Engvall, P PerlmannImmunochemistry19715135623Yes
204913351335.041.441.4Neurotransmitters and neuromodulators in the basal ganglia. A M GraybielTrends Neurosci19901695398No
205026681334.090.7545.4The pathogenesis of rheumatoid arthritis. Iain B McInnes, Georg SchettN Engl J Med201122150039No
205126671333.583.9642.0Astrocytes: biology and pathology. Michael V Sofroniew, Harry V VintersActa Neuropathol201020012068No
205226661333.00.00.0Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. E Engvall, P PerlmannJ Immunol19724113792Yes
205326661333.00.00.0Virus interference. I. The interferon. A Isaacs, J LindenmannProc R Soc Lond B Biol Sci195713465720Yes
205413331333.00.00.0The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. R C LewontinGenetics196417248194Yes
205526651332.551.6825.8Oncogenic kinase signalling. P Blume-Jensen, T HunterNature200111357143No
205626651332.578.1739.1Molecular mechanisms of long noncoding RNAs. Kevin C Wang, Howard Y ChangMol Cell201121925379No
205713321332.035.6235.6The importance of the ratio of omega-6/omega-3 essential fatty acids. A P SimopoulosBiomed Pharmacother200212442909No
205826621331.095.3847.7A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. C M Tsai, C E FraschAnal Biochem19826176137Yes
205939931331.0105.1335.0Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. B Fischl, M I Sereno, A M DaleNeuroimage19999931269Yes
206013311331.046.146.1Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. K Anders EricssonAcad Med200415383395No
206126611330.555.3327.7Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. P J Southern, P BergJ Mol Appl Genet19826286831Yes
206213301330.043.0243.0Glutathione metabolism and its selective modification. A MeisterJ Biol Chem19883053703No
206313301330.00.00.0Origin of concatemeric T7 DNA. J D WatsonNat New Biol19724507727Yes
206426601330.095.4547.7Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. M M Bradley, P J LangJ Behav Ther Exp Psychiatry19947962581Yes
206553201330.0294.8873.7Prevalence of childhood and adult obesity in the United States, 2011-2012. Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M FlegalJAMA201424570244Yes
206613291329.036.0236.0Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. S L FriedmanN Engl J Med19938502273No
206713281328.036.8336.8Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Michael F HolickAm J Clin Nutr200415585788No
206826551327.50.00.0Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. G Blobel, B DobbersteinJ Cell Biol1975811671Yes
206913271327.00.00.0Renin-angiotensin system: biochemistry and mechanisms of action. M J PeachPhysiol Rev1977191856No
207013271327.065.065.0Molecular pathology of schizophrenia: more than one disease process? T J CrowBr Med J19806101544No
207126541327.061.9231.0The pathophysiology and treatment of sepsis. Richard S Hotchkiss, Irene E KarlN Engl J Med200312519925No
207226541327.054.5427.3Wnt signalling in stem cells and cancer. Tannishtha Reya, Hans CleversNature200515829953No
207313271327.043.1843.2The functional gastrointestinal disorders and the Rome III process. Douglas A DrossmanGastroenterology200616678553No
207413271327.030.5130.5Autophagy: from phenomenology to molecular understanding in less than a decade. Daniel J KlionskyNat Rev Mol Cell Biol200717712358No
207526541327.076.9538.5Materials for electrochemical capacitors. Patrice Simon, Yury GogotsiNat Mater200818956000Yes
207613261326.041.241.2Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. M Robin DiMatteoMed Care200415076819Yes
207713251325.047.8647.9Neuropeptide Y: complete amino acid sequence of the brain peptide. K TatemotoProc Natl Acad Sci U S A19826957876Yes
207826481324.00.00.0Immunization of dissociated spleen cell cultures from normal mice. R I Mishell, R W DuttonJ Exp Med19676034749Yes
207913241324.027.227.2Dimerization of cell surface receptors in signal transduction. C H HeldinCell19957834741No
208013241324.049.6549.6Functional and effective connectivity: a review. Karl J FristonBrain Connect201122432952No
208126471323.50.00.0Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. D H Figurski, D R HelinskiProc Natl Acad Sci U S A1979377280Yes
208252941323.5125.031.2Quantitative monitoring of gene expression patterns with a complementary DNA microarray. M Schena, D Shalon, R W Davis, P O BrownScience19957569999Yes
208313231323.045.0845.1Gene flow and the geographic structure of natural populations. M SlatkinScience19873576198Yes
208413231323.00.00.0Cellular resistance to infection. G B MackanessJ Exp Med196214467923Yes
208513231323.033.2133.2Upconversion and anti-Stokes processes with f and d ions in solids. François AuzelChem Rev200414719973Yes
208613211321.026.1926.2Chromosomal translocations in human cancer. T H RabbittsNature19947969446No
208713211321.043.2243.2History of the Rochester Epidemiology Project. L J MeltonMayo Clin Proc19968594285No
208813211321.034.8934.9Interoception: the sense of the physiological condition of the body. A D CraigCurr Opin Neurobiol200312965300No
208913211321.00.00.0Agammaglobulinemia. O C BrutonPediatrics195214929630Yes
209026411320.557.1828.6The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. M S Brown, J L GoldsteinCell19979150132No
209113201320.00.00.0A simple ultraviolet spectrophotometric method for the determination of protein. W J WaddellJ Lab Clin Med195613346201Yes
209213191319.041.8741.9The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. L W SwansonBrain Res Bull19826816390Yes
209313191319.034.2334.2Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. Y ShaiBiochim Biophys Acta199910590302No
209413191319.00.00.0A quantitative immunochemical measure of the primary interaction between I BSA and antibody. R S FarrJ Infect Dis195813611294Yes
209513191319.047.6847.7A Social Neuroscience Perspective on Adolescent Risk-Taking. Laurence SteinbergDev Rev200818509515Yes
209613191319.00.00.0Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. P F ScholanderJ Biol Chem194720281644Yes
209726371318.576.6738.3Lipid rafts as a membrane-organizing principle. Daniel Lingwood, Kai SimonsScience201020044567No
209813181318.035.5135.5Fibronectin and its receptors. E RuoslahtiAnnu Rev Biochem19882972252No
209913181318.062.3562.4Whatever next? Predictive brains, situated agents, and the future of cognitive science. Andy ClarkBehav Brain Sci201323663408No
210013171317.029.5529.6A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Dale R NyholtAm J Hum Genet200414997420Yes
210113151315.00.00.0Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. W W DouglasBr J Pharmacol19684882190No
210213151315.045.1245.1The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. Poul Erik PetersenCommunity Dent Oral Epidemiol200315015736Yes
210326301315.098.9449.5Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Jennifer A Doudna, Emmanuelle CharpentierScience201425430774No
210426291314.552.6526.3Autophagy as a regulated pathway of cellular degradation. D J Klionsky, S D EmrScience200011099404No
210513141314.00.00.0Mate selection-a selection for a handicap. A ZahaviJ Theor Biol19751195756Yes
210613141314.034.8734.9The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. K KuwajimaProteins19892695928No
210726281314.060.7230.4Integrins and signal transduction pathways: the road taken. E A Clark, J S BruggeScience19957716514No
210813141314.027.8827.9Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. R I MorimotoGenes Dev19989869631No
210939401313.30.00.0Improved method for the determination of blood glutathione. E Beutler, O Duron, B M KellyJ Lab Clin Med196313967893Yes
211013131313.00.00.0Letter: Grading of angina pectoris. L CampeauCirculation1976947585Yes
211126261313.00.00.0A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. J A Horne, O OstbergInt J Chronobiol19761027738Yes
211213131313.041.8541.9The phenomenon of the acute phase response. I KushnerAnn N Y Acad Sci19827046585No
211326261313.061.0730.5The RXR heterodimers and orphan receptors. D J Mangelsdorf, R M EvansCell19958521508No
211413131313.037.0437.0Synergy, antagonism, and what the chequerboard puts between them. F C OddsJ Antimicrob Chemother200312805255No
211513131313.00.00.0The Relation Of Recombination To Mutational Advance. H J MullerMutat Res196414195748Yes
211613131313.029.029.0Maintenance of C. elegans. Theresa StiernagleWormBook200618050451No
211713131313.044.5144.5Stress and disorders of the stress system. George P ChrousosNat Rev Endocrinol200919488073No
211813131313.045.7145.7Aging, cellular senescence, and cancer. Judith CampisiAnnu Rev Physiol201323140366No
211913121312.033.8133.8Thioredoxin and glutaredoxin systems. A HolmgrenJ Biol Chem19892668278No
212026241312.078.2839.1Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. C J Murray, A D LopezLancet19979164317Yes
212113121312.033.133.1Tobacco smoke carcinogens and lung cancer. S S HechtJ Natl Cancer Inst199910413421No
212239331311.0141.3347.1Structure-antioxidant activity relationships of flavonoids and phenolic acids. C A Rice-Evans, N J Miller, G PagangaFree Radic Biol Med19968743980Yes
212313101310.036.1136.1A note on robust variance estimation for cluster-correlated data. R L WilliamsBiometrics200010877330Yes
212426181309.060.0630.0Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. E Y Chen, P H SeeburgDNA19853996185Yes
212513091309.031.6431.6Regulation of differentiation of vascular smooth muscle cells. G K OwensPhysiol Rev19957624392No
212613091309.031.731.7Apoptosis in cancer therapy: crossing the threshold. D E FisherCell19948069905No
212713091309.035.9636.0The epidemiology of venous thromboembolism. Richard H WhiteCirculation200312814979No
212813091309.025.8225.8Epithelial-mesenchymal transitions in development and pathologies. Jean Paul ThieryCurr Opin Cell Biol200314644200No
212913091309.034.0834.1Origin, biogenesis, and activity of plant microRNAs. Olivier VoinnetCell200919239888No
213026171308.590.2445.1Thermodynamics of protein association reactions: forces contributing to stability. P D Ross, S SubramanianBiochemistry19817248271Yes
213113081308.033.9934.0N-heterocyclic carbenes: a new concept in organometallic catalysis. Wolfgang A HerrmannAngew Chem Int Ed Engl200219750753Yes
213213071307.050.7250.7Presidential address, 1980. Surprise!...Surprise? E DonchinPsychophysiology19817280146Yes
213313071307.026.7526.8Natively unfolded proteins: a point where biology waits for physics. Vladimir N UverskyProtein Sci200211910019No
213413071307.041.0341.0A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Ozcan ErelClin Biochem200415003729Yes
213513071307.029.4729.5Cancer of the ovary. Stephen A CannistraN Engl J Med200415590954No
213639201306.798.3532.8The p53 tumour suppressor gene. A J Levine, J Momand, C A FinlayNature19912046748No
213713061306.033.3933.4A molecular view of microbial diversity and the biosphere. N R PaceScience19979115194No
213813061306.035.5335.5Understanding biofilm resistance to antibacterial agents. David DaviesNat Rev Drug Discov200312563302No
213926101305.00.00.0Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. L F Berkman, S L SymeAm J Epidemiol1979425958Yes
214013051305.030.730.7Molecular basis of long-term plasticity underlying addiction. E J NestlerNat Rev Neurosci200111252991No
214113051305.033.1433.1Drug-induced prolongation of the QT interval. Dan M RodenN Engl J Med200414999113No
214213051305.037.9337.9Bioactive microbial metabolites. János BérdyJ Antibiot (Tokyo)200515813176No
214313051305.00.00.0The antidiuretic hormone and the factors which determine its release. E B VerneyProc R Soc Lond B Biol Sci194718918876Yes
214439141304.7122.1440.7Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. S van der Linden, H A Valkenburg, A CatsArthritis Rheum19846231933Yes
214513041304.056.5656.6The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. E J KhantzianAm J Psychiatry19853904487No
214613041304.050.7950.8Free-radical mechanisms in tissue injury. T F SlaterBiochem J19846383353No
214713041304.028.0428.0Double identity for proteins of the Bcl-2 family. J C ReedNature19979194558No
214826081304.00.00.0A new scale of social desirability independent of psychopathology. D P Crowne, D MarloweJ Consult Psychol196013813058Yes
214913031303.037.2537.2The matrix-degrading metalloproteinases. L M MatrisianBioessays19921445287No
215013031303.042.0342.0Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. A A GraceNeuroscience19911676137No
215113031303.00.00.0The prevalence of 'alexithymic' characteristics in psychosomatic patients. P E SifneosPsychother Psychosom19734770536Yes
215213031303.029.8129.8Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. W D SniderCell19948205613No
215313021302.024.3324.3Chromatin modification and epigenetic reprogramming in mammalian development. En LiNat Rev Genet200212209141No
215413021302.029.6329.6Critical period plasticity in local cortical circuits. Takao K HenschNat Rev Neurosci200516261181No
215513021302.040.440.4Understanding organofluorine chemistry. An introduction to the C-F bond. David O'HaganChem Soc Rev200818197347No
215626041302.0165.9283.0Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. Ivica Letunic, Peer BorkNucleic Acids Res201627095192Yes
215713001300.085.3885.4The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. F DenisSpine (Phila Pa 1976)19836670016Yes
215826001300.078.4739.2What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. J Zhang, K F YuJAMA19989832001Yes
215913001300.022.3422.3Cancer. Addiction to oncogenes--the Achilles heal of cancer. I Bernard WeinsteinScience200212098689No
216025991299.50.00.0A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. R L Juliano, V LingBiochim Biophys Acta1976990323Yes
216112991299.039.8939.9Recent developments in isocyanide based multicomponent reactions in applied chemistry. Alexander DömlingChem Rev200616402771No
216225981299.057.6228.8NMR View: A computer program for the visualization and analysis of NMR data. B A Johnson, R A BlevinsJ Biomol NMR199422911360Yes
216325971298.555.0627.5Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. J M Kyriakis, J AvruchPhysiol Rev200111274345No
216425971298.5101.3650.7The integrative review: updated methodology. Robin Whittemore, Kathleen KnaflJ Adv Nurs200516268861Yes
216512981298.029.1729.2The ATP synthase--a splendid molecular machine. P D BoyerAnnu Rev Biochem19979242922No
216612981298.034.234.2The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. T SzkudelskiPhysiol Res200111829314No
216712971297.040.840.8Biological basis of the behavior of sick animals. B L HartNeurosci Biobehav Rev19883050629No
216825941297.060.1330.1Disruption of epithelial cell-matrix interactions induces apoptosis. S M Frisch, H FrancisJ Cell Biol19948106557Yes
216912971297.048.5648.6Asthma phenotypes: the evolution from clinical to molecular approaches. Sally E WenzelNat Med201222561835No
217038891296.3104.3434.8The metabolic syndrome. Robert H Eckel, Scott M Grundy, Paul Z ZimmetLancet200515836891No
217112951295.052.0452.0Reliability and factor analysis of the Epworth Sleepiness Scale. M W JohnsSleep19921519015Yes
217238851295.0184.8761.6Risk factors for falls among elderly persons living in the community. M E Tinetti, M Speechley, S F GinterN Engl J Med19883205267Yes
217312951295.00.00.0Hippocampal electrical activity and voluntary movement in the rat. C H VanderwolfElectroencephalogr Clin Neurophysiol19694183562Yes
217412951295.043.3143.3SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. B P O'ConnorBehav Res Methods Instrum Comput200011029811Yes
217512951295.023.9523.9The snail superfamily of zinc-finger transcription factors. M Angela NietoNat Rev Mol Cell Biol200211994736No
217625901295.060.3130.2A comparison of bayesian methods for haplotype reconstruction from population genotype data. Matthew Stephens, Peter DonnellyAm J Hum Genet200314574645Yes
217712951295.031.1731.2Cell signaling. H2O2, a necessary evil for cell signaling. Sue Goo RheeScience200616809515Yes
217838851295.0115.5338.5I-TASSER: a unified platform for automated protein structure and function prediction. Ambrish Roy, Alper Kucukural, Yang ZhangNat Protoc201020360767Yes
217912941294.00.00.0A New Weighting System For Mean Surface Temperature Of The Human Body. N L RamanathanJ Appl Physiol196414173555Yes
218012941294.043.0443.0Formation of glasses from liquids and biopolymers. C A AngellScience199517770101Yes
218112931293.028.328.3The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. G B MorinCell19892805070Yes
218225861293.061.9631.0Production of single-stranded plasmid DNA. J Vieira, J MessingMethods Enzymol19873323803Yes
218312921292.044.8144.8Functional organization of central pathways regulating the cardiovascular system. R A DampneyPhysiol Rev19948171117No
218412921292.039.3939.4Strong localization of photons in certain disordered dielectric superlattices. JohnPhys Rev Lett198710034761Yes
218525831291.597.6148.8Universal chemical assay for the detection and determination of siderophores. B Schwyn, J B NeilandsAnal Biochem19872952030Yes
218625821291.00.00.0Epidermal growth factor. G Carpenter, S CohenAnnu Rev Biochem1979382984No
218712911291.00.00.0Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. Russell LandeEvolution197928568194Yes
218812901290.036.6936.7The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. R G GerrityAm J Pathol19817234961Yes
218912901290.024.2424.2CD95's deadly mission in the immune system. P H KrammerNature200011048730No
219012901290.033.9534.0Clinical features of metastatic bone disease and risk of skeletal morbidity. Robert E ColemanClin Cancer Res200617062708No
219151571289.2129.1932.3The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten SchwedeBioinformatics200616301204Yes
219212891289.031.331.3Receptors for epidermal growth factor and other polypeptide mitogens. G CarpenterAnnu Rev Biochem19873039909No
219312891289.029.2829.3Target-oriented and diversity-oriented organic synthesis in drug discovery. S L SchreiberScience200010720315No
219412891289.040.8940.9Ordinary magic. Resilience processes in development. A S MastenAm Psychol200111315249Yes
219512891289.024.6524.6The significance of responses of the genome to challenge. B McClintockScience198415739260No
219625771288.574.2937.1Regulation of chromatin by histone modifications. Andrew J Bannister, Tony KouzaridesCell Res201121321607No
219725761288.090.645.3The framing of decisions and the psychology of choice. A Tversky, D KahnemanScience19817455683Yes
219838641288.0103.1134.4How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. R M Sapolsky, L M Romero, A U MunckEndocr Rev200010696570No
219912881288.038.438.4The debate over dopamine's role in reward: the case for incentive salience. Kent C BerridgePsychopharmacology (Berl)200717072591No
220012871287.034.334.3Phylogenies from molecular sequences: inference and reliability. J FelsensteinAnnu Rev Genet19883071258No
220112871287.038.1338.1The origins of the developmental origins theory. D J P BarkerJ Intern Med200717444880No
220225731286.50.00.0Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. J A Ledbetter, L A HerzenbergImmunol Rev1979398327No
220312861286.024.3224.3Antigen-specific interaction between T and B cells. A LanzavecchiaNature19853157869Yes
220412861286.030.0130.0Mitochondria: dynamic organelles in disease, aging, and development. David C ChanCell200616814712No
220551431285.8127.5231.9Improved prediction of signal peptides: SignalP 3.0. Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren BrunakJ Mol Biol200415223320Yes
220625691284.50.00.0A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. B G Durie, S E SalmonCancer19751182674Yes
220725691284.569.8434.9Abdominal obesity and metabolic syndrome. Jean-Pierre Després, Isabelle LemieuxNature200617167477No
220825681284.00.00.0Functions of lysosomes. C De Duve, R WattiauxAnnu Rev Physiol19665322983No
220912841284.023.2223.2Protein modification by SUMO. Erica S JohnsonAnnu Rev Biochem200415189146No
221012841284.039.0139.0Multiple imputation of discrete and continuous data by fully conditional specification. Stef van BuurenStat Methods Med Res200717621469Yes
2211115531283.7367.0140.8The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C DunbarJ Clin Psychiatry19989881538No
221225661283.00.00.0Regulatory sequences involved in the promotion and termination of RNA transcription. M Rosenberg, D CourtAnnu Rev Genet197994251No
221312831283.00.00.0Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. J H LuftAnat Rec19714108333Yes
221412831283.023.2623.3Regulatory T cells: key controllers of immunologic self-tolerance. S SakaguchiCell200010850488No
221512821282.00.00.0Cardiovascular and renal actions of dopamine: potential clinical applications. L I GoldbergPharmacol Rev19724554480No
221612821282.034.0634.1Hemispheric asymmetry reduction in older adults: the HAROLD model. Roberto CabezaPsychol Aging200211931290No
221712811281.048.2248.2Quantitative methods in the review of epidemiologic literature. S GreenlandEpidemiol Rev19873678409Yes
221812811281.00.00.0Electrophoretic separation of plasma lipoproteins in agarose gel. R P NobleJ Lipid Res19684176473Yes
221912811281.00.00.0Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. A BöyumScand J Clin Lab Invest Suppl19684179066Yes
222012811281.035.6735.7Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. P LipsEndocr Rev200111493580No
222112811281.041.9441.9Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Thomas HebererToxicol Lett200211988354Yes
222212811281.00.00.0Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. H M KalckarJ Biol Chem194720285041Yes
222325611280.547.8223.9New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. R D Gietz, A SuginoGene19883073106Yes
222425601280.00.00.0Glutathione peroxidase activity in selenium-deficient rat liver. R A Lawrence, R F BurkBiochem Biophys Res Commun1976971321Yes
222512801280.030.7230.7Lymphokine production by human T cells in disease states. S RomagnaniAnnu Rev Immunol19948011282No
222612801280.039.7539.8Graphene transistors. Frank SchwierzNat Nanotechnol201020512128Yes
222725581279.00.00.0The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. J Shine, L DalgarnoProc Natl Acad Sci U S A19744598299Yes
222812791279.063.7963.8Chronic illness as biographical disruption. M BurySociol Health Illn198210260456Yes
222912791279.028.228.2Stability and flexibility of epigenetic gene regulation in mammalian development. Wolf ReikNature200717522676No
2230204521278.2751.7747.0Fiji: an open-source platform for biological-image analysis. Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert CardonaNat Methods201222743772Yes
223112781278.046.9346.9Substance P. B PernowPharmacol Rev19836196797No
223212781278.033.9834.0The aryl hydrocarbon receptor complex. O HankinsonAnnu Rev Pharmacol Toxicol19957598497No
223338341278.0105.9235.3TCS: a computer program to estimate gene genealogies. M Clement, D Posada, K A CrandallMol Ecol200011050560Yes
223476661277.7278.2246.4TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L SalzbergGenome Biol201323618408Yes
223525551277.543.3521.7Genetic transformation of Drosophila with transposable element vectors. G M Rubin, A C SpradlingScience19826289436Yes
223612771277.033.7933.8Supported membranes: scientific and practical applications. E SackmannScience19968539599No
223712771277.022.8122.8Clonal selection and learning in the antibody system. K RajewskyNature19968657279No
223825541277.057.9729.0Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Joshua E Elias, Steven P GygiNat Methods200717327847Yes
223925541277.059.4729.7Cellular senescence: when bad things happen to good cells. Judith Campisi, Fabrizio d'Adda di FagagnaNat Rev Mol Cell Biol200717667954No
224025521276.055.3327.7Liver regeneration. G K Michalopoulos, M C DeFrancesScience19979082986No
224125521276.079.8439.9Genome regulation by long noncoding RNAs. John L Rinn, Howard Y ChangAnnu Rev Biochem201222663078No
224238271275.794.9531.7Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Daniel Falush, Matthew Stephens, Jonathan K PritchardGenetics200312930761Yes
224312751275.038.9839.0Diversity and ubiquity of K channels. B RudyNeuroscience19882457185No
224438251275.0146.1648.7CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Teresa C Horan, Mary Andrus, Margaret A DudeckAm J Infect Control200818538699No
224525501275.077.939.0miRBase: integrating microRNA annotation and deep-sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201121037258Yes
224625491274.584.6642.3The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. W R Gibb, A J LeesJ Neurol Neurosurg Psychiatry19882841426No
224712741274.048.0948.1The life and times of the Enterococcus. B E MurrayClin Microbiol Rev19902404568No
224812741274.042.0942.1Chlorophyll fluorescence: a probe of photosynthesis in vivo. Neil R BakerAnnu Rev Plant Biol200818444897No
224950951273.8153.2838.3Reversible middle cerebral artery occlusion without craniectomy in rats. E Z Longa, P R Weinstein, S Carlson, R CumminsStroke19892643202Yes
225012731273.034.5234.5Signaling through phosphatidylcholine breakdown. J H ExtonJ Biol Chem19902104616No
225112731273.068.1268.1The determinants of parenting: a process model. J BelskyChild Dev19846705636Yes
225225461273.071.9636.0Bronchopulmonary dysplasia. A H Jobe, E BancalariAm J Respir Crit Care Med200111401896No
225338181272.780.0926.7The versatility and universality of calcium signalling. M J Berridge, P Lipp, M D BootmanNat Rev Mol Cell Biol200011413485No
225425451272.563.1631.6The DNA damage response: making it safe to play with knives. Alberto Ciccia, Stephen J ElledgeMol Cell201020965415No
225512721272.00.00.0The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. R G KhalifahJ Biol Chem19714994926Yes
225612721272.041.9642.0Somatostatin. S ReichlinN Engl J Med19836139753No
225725441272.063.2731.6Inflammation, stress, and diabetes. Kathryn E Wellen, Gökhan S HotamisligilJ Clin Invest200515864338No
225825431271.50.00.0Establishment and characterization of a human histiocytic lymphoma cell line (U-937). C Sundström, K NilssonInt J Cancer1976178611Yes
225925431271.568.2134.1Cell signaling by receptor tyrosine kinases. Mark A Lemmon, Joseph SchlessingerCell201020602996No
226025421271.00.00.0Prediction of the secondary structure of proteins from their amino acid sequence. P Y Chou, G D FasmanAdv Enzymol Relat Areas Mol Biol1978364941No
226112711271.042.3742.4Signal transduction by reactive oxygen species. Toren FinkelJ Cell Biol201121746850No
226225421271.0184.9292.5Natural Products as Sources of New Drugs from 1981 to 2014. David J Newman, Gordon M CraggJ Nat Prod201626852623No
226312701270.031.1231.1Proinflammatory cytokines. C A DinarelloChest200010936147No
226412701270.042.1842.2The law of attrition. Gunther EysenbachJ Med Internet Res200515829473Yes
226538081269.384.5628.2Multidrug resistance in cancer: role of ATP-dependent transporters. Michael M Gottesman, Tito Fojo, Susan E BatesNat Rev Cancer200211902585No
226612691269.063.8563.9Optical properties of biological tissues: a review. Steven L JacquesPhys Med Biol201323666068No
226725371268.553.0526.5Short-term synaptic plasticity. Robert S Zucker, Wade G RegehrAnnu Rev Physiol200211826273No
226825361268.062.3831.2Multipoint quantitative-trait linkage analysis in general pedigrees. L Almasy, J BlangeroAm J Hum Genet19989545414Yes
226912671267.037.9638.0Treatment of infections associated with surgical implants. Rabih O DarouicheN Engl J Med200415070792No
227012661266.00.00.0Diversity in tropical rain forests and coral reefs. J H ConnellScience197817840770Yes
227125311265.50.00.0A rapid, sensitive, and specific method for the determination of protein in dilute solution. W Schaffner, C WeissmannAnal Biochem19734128882Yes
227225311265.549.9625.0Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. M Fried, D M CrothersNucleic Acids Res19816275366Yes
227325311265.580.9740.5Porosity of 3D biomaterial scaffolds and osteogenesis. Vassilis Karageorgiou, David KaplanBiomaterials200515860204No
227412641264.046.0246.0The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. A RaineSchizophr Bull19911805349Yes
227512641264.033.1333.1Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. R M SapolskyArch Gen Psychiatry200011015810No
227612641264.034.034.0Marine viruses--major players in the global ecosystem. Curtis A SuttleNat Rev Microbiol200717853907No
227725281264.073.0236.5The gut microbiota shapes intestinal immune responses during health and disease. June L Round, Sarkis K MazmanianNat Rev Immunol200919343057No
227812641264.047.047.0Phase retrieval algorithms: a comparison. J R FienupAppl Opt198220396114Yes
227975821263.7205.5334.3Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur WheelerN Engl J Med200010793162Yes
228012631263.027.6327.6Codon usage and tRNA content in unicellular and multicellular organisms. T IkemuraMol Biol Evol19853916708No
228112621262.029.1729.2Chemistry and biology of the immunophilins and their immunosuppressive ligands. S L SchreiberScience19911702904No
228212621262.040.7940.8The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. J L CummingsNeurology19979153155No
228312621262.038.338.3Osteoblast adhesion on biomaterials. K AnselmeBiomaterials200010711964No
228425231261.579.6139.8The benefits of being present: mindfulness and its role in psychological well-being. Kirk Warren Brown, Richard M RyanJ Pers Soc Psychol200312703651Yes
228563061261.20.00.0Enzymatic determination of total serum cholesterol. C C Allain, L S Poon, C S Chan, W Richmond, P C FuClin Chem19744818200Yes
228612611261.00.00.0The intraclass correlation coefficient as a measure of reliability. J J BartkoPsychol Rep19665942109Yes
228712611261.027.7427.7HIF-1: mediator of physiological and pathophysiological responses to hypoxia. G L SemenzaJ Appl Physiol (1985)200010749844No
228812611261.028.8828.9Gene finding in novel genomes. Ian KorfBMC Bioinformatics200415144565Yes
228937811260.382.5227.5A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. R Medzhitov, P Preston-Hurlburt, C A JanewayNature19979237759Yes
229012601260.052.4652.5Error in medicine. L L LeapeJAMA19947503827Yes
229162991259.8193.2438.6Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939839Yes
229212591259.00.00.0Structure and function of intercellular junctions. L A StaehelinInt Rev Cytol19744611943No
229312591259.026.2226.2SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. S V EvansJ Mol Graph19938347566Yes
229412591259.035.4735.5Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. E B HunzikerOsteoarthritis Cartilage200212056848No
229512591259.029.1329.1Topoisomerase I inhibitors: camptothecins and beyond. Yves PommierNat Rev Cancer200616990856No
229612591259.00.00.0Limitations of the application of fourfold table analysis to hospital data. J BerksonBiometrics194621001024Yes
229725171258.576.1938.1The Measurement Of Selection On Correlated Characters. Russell Lande, Stevan J ArnoldEvolution198328556011Yes
229812581258.044.9945.0Carnitine--metabolism and functions. J BremerPhysiol Rev19836361812No
229925151257.586.7743.4Oncology meets immunology: the cancer-immunity cycle. Daniel S Chen, Ira MellmanImmunity201323890059No
230062871257.4240.848.2Evidence based medicine: what it is and what it isn't. D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S RichardsonBMJ19968555924No
230112571257.00.00.0Strategy and tactics in protein chemistry. B S HartleyBiochem J19704923920No
230212571257.043.2743.3Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. R LotanBiochim Biophys Acta19806989400No
230312571257.026.3326.3Signal transduction via the MAP kinases: proceed at your own RSK. J BlenisProc Natl Acad Sci U S A19938392180No
230425141257.056.1828.1LTP and LTD: an embarrassment of riches. Robert C Malenka, Mark F BearNeuron200415450156No
230512561256.00.00.0The origin of the genetic code. F H CrickJ Mol Biol19684887876Yes
230612561256.031.8431.8Apoptosis. J J CohenImmunol Today19938466628No
230725121256.057.2728.6Escaping free-energy minima. Alessandro Laio, Michele ParrinelloProc Natl Acad Sci U S A200212271136Yes
230812561256.026.8526.9The many faces of macrophage activation. David M MosserJ Leukoc Biol200312554797No
230937681256.0136.9945.7Global estimates of the prevalence of diabetes for 2010 and 2030. J E Shaw, R A Sicree, P Z ZimmetDiabetes Res Clin Pract201019896746Yes
231012551255.00.00.0Disconnexion syndromes in animals and man. I. N GeschwindBrain19655318481No
231112551255.046.6646.7Inflammation in atherosclerosis. Peter LibbyArterioscler Thromb Vasc Biol201222895665No
231225091254.565.1632.6Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. M P Lutolf, J A HubbellNat Biotechnol200515637621No
231312541254.025.8525.9Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. R H SchwartzCell19921335362No
231412541254.031.2731.3The 'effective number of codons' used in a gene. F WrightGene19902110097Yes
231512541254.033.8333.8Reconciling the chemistry and biology of reactive oxygen species. Christine C WinterbournNat Chem Biol200818421291No
231637611253.7123.6441.2Simultaneous inference in general parametric models. Torsten Hothorn, Frank Bretz, Peter WestfallBiom J200818481363No
231725061253.067.5633.8Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. J L Weber, P E MayAm J Hum Genet19892916582Yes
231812531253.030.5330.5Papillomavirus infections--a major cause of human cancers. H zur HausenBiochim Biophys Acta19968876633No
231912531253.023.3223.3c-Myc target genes involved in cell growth, apoptosis, and metabolism. C V DangMol Cell Biol19999858526No
232012531253.031.6831.7Fast and robust fixed-point algorithms for independent component analysis. A HyvärinenIEEE Trans Neural Netw199918252563Yes
232125061253.085.2842.6Oxidative stress and diabetic complications. Ferdinando Giacco, Michael BrownleeCirc Res201021030723No
232225051252.555.7627.9Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. M Zuker, P StieglerNucleic Acids Res19816163133Yes
232312521252.028.4928.5Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. T A SpringerAnnu Rev Physiol19957778885No
232425041252.066.2733.1Apoptosis, oncosis, and necrosis. An overview of cell death. G Majno, I JorisAm J Pathol19957856735No
232525041252.055.7827.9Mitochondrial control of cell death. G Kroemer, J C ReedNat Med200010802706No
232625041252.046.1923.1Rab proteins as membrane organizers. M Zerial, H McBrideNat Rev Mol Cell Biol200111252952No
232725031251.558.2429.1DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. S Tabor, C C RichardsonProc Natl Acad Sci U S A19873474623Yes
232812511251.028.2828.3Life, death, and the pursuit of apoptosis. E WhiteGenes Dev19968557188No
232912511251.036.8236.8Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. P WillnerPsychopharmacology (Berl)19979452163No
233087541250.6268.0238.3Cancer statistics, 2008. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J ThunCA Cancer J Clin200818287387Yes
233112501250.00.00.0Bee and wasp venoms. E HabermannScience19724113805No
233212501250.045.245.2Multimodal approach to control postoperative pathophysiology and rehabilitation. H KehletBr J Anaesth19979175983No
233312491249.030.6830.7Short-term synaptic plasticity. R S ZuckerAnnu Rev Neurosci19892648947No
233437451248.394.6731.6Long non-coding RNAs: insights into functions. Tim R Mercer, Marcel E Dinger, John S MattickNat Rev Genet200919188922No
233512481248.020.8220.8Antigen receptor tail clue. M RethNature19892927501Yes
233612481248.025.8625.9Searching for genetic determinants in the new millennium. N J RischNature200010866211No
233712471247.030.2430.2Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? Rui WangFASEB J200212409322Yes
233812471247.00.00.0On the local reactions of the arterial wall to changes of internal pressure. W M BaylissJ Physiol190216992618Yes
233912471247.035.8935.9Stress and depression. Constance HammenAnnu Rev Clin Psychol200517716090No
234012471247.056.456.4Selenium and human health. Margaret P RaymanLancet201222381456No
234124931246.550.3125.2Prediction of complete gene structures in human genomic DNA. C Burge, S KarlinJ Mol Biol19979149143Yes
234212461246.00.00.0The effective period of preventive antibiotic action in experimental incisions and dermal lesions. J F BurkeSurgery196116722001Yes
234324901245.064.732.4The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Clay B Holroyd, Michael G H ColesPsychol Rev200212374324Yes
234412441244.041.7441.7Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. Chao-Jun LiAcc Chem Res200919220064Yes
234524881244.070.4635.2Molecular replacement with MOLREP. Alexei Vagin, Alexei TeplyakovActa Crystallogr D Biol Crystallogr201020057045Yes
234624871243.557.0428.5Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. D A Brown, J K RoseCell19921531449Yes
234724871243.552.2426.1The molecular biology of axon guidance. M Tessier-Lavigne, C S GoodmanScience19968895455No
234824871243.5112.4356.2Natural products as sources of new drugs over the 30 years from 1981 to 2010. David J Newman, Gordon M CraggJ Nat Prod201222316239No
234912431243.00.00.0A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. A M OlovnikovJ Theor Biol19734754905Yes
235012431243.00.00.0The critical incident technique. J C FlanaganPsychol Bull195413177800Yes
235112431243.034.2434.2Genetic consequences of climatic oscillations in the Quaternary. G M HewittPhilos Trans R Soc Lond B Biol Sci200415101575No
235224851242.574.7237.4Epidemiology of invasive candidiasis: a persistent public health problem. M A Pfaller, D J DiekemaClin Microbiol Rev200717223626No
235312421242.071.3971.4The brain's default mode network. Marcus E RaichleAnnu Rev Neurosci201525938726No
235424821241.073.2536.6Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. J I Morgan, T CurranAnnu Rev Neurosci19911903243No
235512411241.037.6137.6Circuitry and functional aspects of the insular lobe in primates including humans. J R AugustineBrain Res Brain Res Rev19968957561No
235612411241.00.00.0A modification of receptor theory. R P StephensonBr J Pharmacol Chemother195613383117Yes
235712411241.023.0923.1SUMO: a history of modification. Ronald T HayMol Cell200515808504No
235862011240.20.00.0Transection of the oesophagus for bleeding oesophageal varices. R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R WilliamsBr J Surg19734541913Yes
235912401240.00.00.0The biologic clock: the mitochondria? D HarmanJ Am Geriatr Soc19725016631Yes
236012401240.025.7525.8Endocytosis and molecular sorting. I MellmanAnnu Rev Cell Dev Biol19968970738No
236112401240.029.4929.5Refined structure of the nicotinic acetylcholine receptor at 4A resolution. Nigel UnwinJ Mol Biol200515701510Yes
236224801240.052.626.3A general framework for weighted gene co-expression network analysis. Bin Zhang, Steve HorvathStat Appl Genet Mol Biol200516646834Yes
236324801240.067.8333.9ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. Markus Wiederstein, Manfred J SipplNucleic Acids Res200717517781Yes
236424791239.566.0433.0A globally coherent fingerprint of climate change impacts across natural systems. Camille Parmesan, Gary YoheNature200312511946Yes
236524791239.565.0132.5Powering the planet: chemical challenges in solar energy utilization. Nathan S Lewis, Daniel G NoceraProc Natl Acad Sci U S A200617043226Yes
236612391239.040.9841.0An application of prefrontal cortex function theory to cognitive aging. R L WestPsychol Bull19968831298No
236761951239.0159.1431.8Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory CollinsLancet200212493255Yes
236824781239.00.00.0The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. B N Ames, D T DubinJ Biol Chem196013793161Yes
236924781239.065.5432.8The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Daniel J Drucker, Michael A NauckLancet200617098089No
237024761238.089.6844.8Total energy intake: implications for epidemiologic analyses. W Willett, M J StampferAm J Epidemiol19863521261No
237112381238.042.4242.4How is the level of free arachidonic acid controlled in mammalian cells? R F IrvineBiochem J19826810878No
237212381238.022.022.0The economics of ribosome biosynthesis in yeast. J R WarnerTrends Biochem Sci199910542411No
237312381238.00.00.0Sequential tests for the detection of linkage. N E MortonAm J Hum Genet195513258560Yes
237461881237.6150.9230.2Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L CoffmanJ Immunol19862419430Yes
237512371237.038.5638.6Classification of chronic viral hepatitis: a need for reassessment. P J ScheuerJ Hepatol19911808228No
237624741237.00.00.0Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. G J Todaro, H GreenJ Cell Biol196313985244Yes
237724731236.591.1845.6The stunned myocardium: prolonged, postischemic ventricular dysfunction. E Braunwald, R A KlonerCirculation19826754130No
237812361236.031.2831.3The blood-brain barrier: bottleneck in brain drug development. William M PardridgeNeuroRx200515717053No
237924711235.566.6533.3Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. S Schulman, C KearonJ Thromb Haemost200515842354Yes
238037051235.0113.6937.9A rapid bootstrap algorithm for the RAxML Web servers. Alexandros Stamatakis, Paul Hoover, Jacques RougemontSyst Biol200818853362Yes
238124691234.577.6738.8The cortical organization of speech processing. Gregory Hickok, David PoeppelNat Rev Neurosci200717431404No
238224681234.00.00.0Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. A Fabiato, F FabiatoJ Physiol (Paris)1979533865Yes
238312341234.047.1447.1The structure of beta-lactamases. R P AmblerPhilos Trans R Soc Lond B Biol Sci19806109327Yes
238412341234.031.2131.2Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. J DeisenhoferBiochemistry19817236608Yes
238512341234.024.8824.9STATs: signal transducers and activators of transcription. J N IhleCell19968608586No
238649351233.8217.1554.3Bayesian phylogenetics with BEAUti and the BEAST 1.7. Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew RambautMol Biol Evol201222367748Yes
238712331233.00.00.0A restriction point for control of normal animal cell proliferation. A B PardeeProc Natl Acad Sci U S A19744524638Yes
238812331233.034.1834.2Diagnosis of osteoporosis and assessment of fracture risk. John A KanisLancet200212057569No
238924651232.559.1729.6Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Jane E Visvader, Geoffrey J LindemanNat Rev Cancer200818784658No
239024641232.062.6931.3Interneurons of the hippocampus. T F Freund, G BuzsákiHippocampus19968915675No
239136951231.798.7732.9Cognitive and emotional influences in anterior cingulate cortex. Bush, Luu, PosnerTrends Cogn Sci200010827444Yes
239236951231.787.429.1Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. Christian W Tornøe, Caspar Christensen, Morten MeldalJ Org Chem200211975567Yes
239324621231.062.0831.0Pharmacology and functions of metabotropic glutamate receptors. P J Conn, J P PinAnnu Rev Pharmacol Toxicol19979131252No
239424611230.589.6644.8How useful is SBF in predicting in vivo bone bioactivity? Tadashi Kokubo, Hiroaki TakadamaBiomaterials200616448693No
239512301230.00.00.0Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. P RakicJ Comp Neurol19714101340Yes
239612301230.00.00.0A new readability yardstick. R FleschJ Appl Psychol194818867058Yes
239712301230.057.5357.5Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement. Virginia A MoyerAnn Intern Med201424378917No
239824591229.581.4540.7Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. Johan W S Vlaeyen, Steven J LintonPain200010781906No
239973761229.3185.7631.0GROMACS: fast, flexible, and free. David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C BerendsenJ Comput Chem200516211538Yes
240012291229.034.8434.8Tumor angiogenesis. J FolkmanAdv Cancer Res19852581424No
240112291229.029.0329.0Oxyradicals and DNA damage. L J MarnettCarcinogenesis200010688856No
240212291229.00.00.0On the psychophysical law. S S StevensPsychol Rev195713441853Yes
240324581229.076.2238.1CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. Mattias Jakobsson, Noah A RosenbergBioinformatics200717485429Yes
240412291229.047.6847.7Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. T Florian JaegerJ Mem Lang200819884961Yes
240536851228.3167.6855.9In search of how people change. Applications to addictive behaviors. J O Prochaska, C C DiClemente, J C NorcrossAm Psychol19921329589Yes
240612281228.035.0435.0Emotion regulation: affective, cognitive, and social consequences. James J GrossPsychophysiology200212212647No
240712281228.033.2533.2The human orbitofrontal cortex: linking reward to hedonic experience. Morten L KringelbachNat Rev Neurosci200516136173No
240812281228.053.6753.7MorphoJ: an integrated software package for geometric morphometrics. Christian Peter KlingenbergMol Ecol Resour201121429143Yes
240912271227.060.2260.2New norms of upper limb fat and muscle areas for assessment of nutritional status. A R FrisanchoAm J Clin Nutr19816975564Yes
241024541227.047.5723.8Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. C Li, W H WongProc Natl Acad Sci U S A200111134512Yes
241112271227.024.424.4microRNAs: tiny regulators with great potential. V AmbrosCell200111779458No
241224541227.0114.5257.3ROS function in redox signaling and oxidative stress. Michael Schieber, Navdeep S ChandelCurr Biol201424845678No
241312261226.031.631.6The mitochondrial electron transport and oxidative phosphorylation system. Y HatefiAnnu Rev Biochem19852862839No
241424521226.0116.1158.1A new initiative on precision medicine. Francis S Collins, Harold VarmusN Engl J Med201525635347Yes
241524511225.50.00.0Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. J M Tanner, R H WhitehouseArch Dis Child1976952550Yes
241624511225.552.2126.1Regulated portals of entry into the cell. Sean D Conner, Sandra L SchmidNature200312621426No
241712251225.043.1243.1The theoretical bases of indirect calorimetry: a review. E FerranniniMetabolism19883278194No
241812251225.037.7237.7Calcium channel modulation by neurotransmitters, enzymes and drugs. H ReuterNature19836131381No
241912251225.022.5422.5Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. H E RuleyNature19836308473Yes
242012251225.028.1428.1Physiological and molecular basis of thyroid hormone action. P M YenPhysiol Rev200111427693No
242124501225.00.00.0Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. H A Edmondson, P E SteinerCancer195413160935Yes
242273501225.0185.4930.9Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O LötvallNat Cell Biol200717486113Yes
2423134721224.7381.3734.7The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J RoccellaJAMA200312748199No
242424491224.563.5431.8Genetic dissection of complex traits. E S Lander, N J SchorkScience19948091226No
242512241224.031.7331.7Rapid evolution of a protein in vitro by DNA shuffling. W P StemmerNature19948047147Yes
242612231223.049.8149.8An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. J Kabat-ZinnGen Hosp Psychiatry19827042457Yes
242712231223.034.3734.4The cancer stem cell: premises, promises and challenges. Hans CleversNat Med201121386835No
242885551222.1356.6250.9Development and validation of a geriatric depression screening scale: a preliminary report. J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O LeirerJ Psychiatr Res19827183759Yes
242924441222.00.00.0Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. G K McMaster, G G CarmichaelProc Natl Acad Sci U S A197773185Yes
243012221222.00.00.0Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. P O SeglenExp Cell Res19734358115Yes
243112221222.035.4535.5Atopic dermatitis. Thomas BieberN Engl J Med200818385500Yes
243224431221.568.334.1Nitric oxide synthases: roles, tolls, and controls. C Nathan, Q W XieCell19947522969No
243312211221.00.00.0Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. W D HamiltonScience19676021675Yes
243436631221.0131.7343.9A new method for off-line removal of ocular artifact. G Gratton, M G Coles, E DonchinElectroencephalogr Clin Neurophysiol19836187540Yes
243512211221.028.0828.1Diarylethenes for Memories and Switches. Masahiro IrieChem Rev200011777416Yes
243624411220.561.4830.7Molecular mechanisms of action of steroid/thyroid receptor superfamily members. M J Tsai, B W O'MalleyAnnu Rev Biochem19947979245No
243736611220.389.3729.8Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Witold Filipowicz, Suvendra N Bhattacharyya, Nahum SonenbergNat Rev Genet200818197166No
243812201220.036.8836.9Qinghaosu (artemisinin): an antimalarial drug from China. D L KlaymanScience19853887571No
243924401220.079.739.9Oxidative mechanisms in the toxicity of metal ions. S J Stohs, D BagchiFree Radic Biol Med19957744317No
244012201220.024.6424.6Mechanisms of caspase activation and inhibition during apoptosis. Yigong ShiMol Cell200211931755No
244112201220.00.00.0The anterior approach for removal of ruptured cervical disks. R B ClowardJ Neurosurg195813599052Yes
244212201220.035.1135.1Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Arnold I CaplanJ Cell Physiol200717620285No
244312201220.028.8628.9Mechanisms of foxp3+ T regulatory cell-mediated suppression. Ethan M ShevachImmunity200919464986No
244412201220.00.00.0Observations on the isolated phrenic nerve diaphragm preparation of the rat. E BulbringBr J Pharmacol Chemother194620999334Yes
244512191219.024.5924.6Cytokines induce the development of functionally heterogeneous T helper cell subsets. A O'GarraImmunity19989529145No
244624381219.046.2623.1Live or let die: the cell's response to p53. Karen H Vousden, Xin LuNat Rev Cancer200212154352No
244712181218.027.0427.0Heterotrimeric G proteins: organizers of transmembrane signals. E J NeerCell19957834744No
244812181218.031.0331.0Endothelial-leukocyte adhesion molecules. M P BevilacquaAnnu Rev Immunol19938476577No
244912181218.034.7334.7Polycystic ovary syndrome. David A EhrmannN Engl J Med200515788499No
245024351217.575.0137.5Mediation in experimental and nonexperimental studies: new procedures and recommendations. Patrick E Shrout, Niall BolgerPsychol Methods200212530702Yes
245124351217.569.4334.7The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. W L Jorgensen, J Tirado-RivesJ Am Chem Soc198827557051Yes
245273031217.2190.8231.8A default mode of brain function. M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L ShulmanProc Natl Acad Sci U S A200111209064Yes
245324331216.50.00.0Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. J E Sulston, H R HorvitzDev Biol1977838129Yes
245412161216.035.4735.5Peptide antibiotics and their role in innate immunity. H G BomanAnnu Rev Immunol19957612236No
245524321216.065.3932.7Therapeutic potential of resveratrol: the in vivo evidence. Joseph A Baur, David A SinclairNat Rev Drug Discov200616732220No
245648591214.8143.4635.9Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Weidner, J P Semple, W R Welch, J FolkmanN Engl J Med19911701519Yes
245724281214.074.6937.3An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Sun Ho Kim, Jin Mo ChungPain19921333581Yes
245812141214.028.828.8The Unified Medical Language System (UMLS): integrating biomedical terminology. Olivier BodenreiderNucleic Acids Res200414681409Yes
245960691213.8193.0238.6Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. J S Beckman, T W Beckman, J Chen, P A Marshall, B A FreemanProc Natl Acad Sci U S A19902154753Yes
246024271213.561.9131.0The free radical theory of aging matures. K B Beckman, B N AmesPhysiol Rev19989562038No
246124261213.00.00.0High resolution acrylamide gel electrophoresis of histones. S Panyim, R ChalkleyArch Biochem Biophys19695778650Yes
246224261213.069.8234.9Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Robert E W Hancock, Hans-Georg SahlNat Biotechnol200617160061No
246324261213.081.6440.8Quality control and preprocessing of metagenomic datasets. Robert Schmieder, Robert EdwardsBioinformatics201121278185Yes
246436381212.796.9632.3Membrane lipids: where they are and how they behave. Gerrit van Meer, Dennis R Voelker, Gerald W FeigensonNat Rev Mol Cell Biol200818216768No
246524251212.544.1822.1The DNA damage response: putting checkpoints in perspective. B B Zhou, S J ElledgeNature200011100718No
246696971212.1251.7831.5Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M JoliotNeuroimage200211771995Yes
246724241212.039.8519.9A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. D Tautz, C PfeifleChromosoma19892476281Yes
246812121212.026.3226.3Antigen-presenting function of the macrophage. E R UnanueAnnu Rev Immunol19846242349No
246948451211.2113.7328.4Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J ThunN Engl J Med200312711737Yes
247012111211.054.5654.6Human agency in social cognitive theory. A BanduraAm Psychol19892782727Yes
247112111211.055.6355.6Derivation and validation of a short-form oral health impact profile. G D SladeCommunity Dent Oral Epidemiol19979332805Yes
247224221211.054.5127.3The pathophysiology of mitochondrial cell death. Douglas R Green, Guido KroemerScience200415286356No
247312111211.028.6828.7DNA damage, aging, and cancer. Jan H J HoeijmakersN Engl J Med200919812404No
247424211210.568.8134.4What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? K C Berridge, T E RobinsonBrain Res Brain Res Rev19989858756No
247536311210.3110.8937.0Oxidants, antioxidants, and the degenerative diseases of aging. B N Ames, M K Shigenaga, T M HagenProc Natl Acad Sci U S A19938367443No
247612101210.033.8933.9Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. F HeftiJ Neurosci19863746405Yes
247712101210.027.3127.3The stem-cell niche as an entity of action. David T ScaddenNature200616810242No
247824191209.575.7737.9Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. D Filmer, L H PritchettDemography200111227840Yes
247912091209.055.4155.4Continuous improvement as an ideal in health care. D M BerwickN Engl J Med19892909878Yes
248024181209.045.5822.8DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Christopher J Bakkenist, Michael B KastanNature200312556884Yes
248124171208.50.00.0Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Altman, G D DasJ Comp Neurol19655861717Yes
248236251208.394.8831.6Atomic force microscope. Binnig, Quate, GerberPhys Rev Lett198610033323Yes
2483132791207.2331.1530.1New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G GwytherJ Natl Cancer Inst200010655437No
248424141207.047.2823.6CpG islands in vertebrate genomes. M Gardiner-Garden, M FrommerJ Mol Biol19873656447Yes
248512071207.038.4438.4Linkage map of Escherichia coli K-12, edition 7. B J BachmannMicrobiol Rev19836348505No
248612071207.025.4725.5MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. R N GermainCell19948293464No
248712061206.067.0967.1Psychosocial resilience and protective mechanisms. Michael RutterAm J Orthopsychiatry19873303954No
248824121206.00.00.0The Aggregation Of Blood Platelets. G V Born, M J CrossJ Physiol196314056485Yes
248912061206.089.5489.5Metazoan MicroRNAs. David P BartelCell201829570994No
249012051205.032.5632.6Low density lipoprotein oxidation and its pathobiological significance. D SteinbergJ Biol Chem19979261091No
249112051205.036.2136.2Invasive aspergillosis. D W DenningClin Infect Dis19989564455No
249224101205.062.1931.1Neuronal plasticity: increasing the gain in pain. C J Woolf, M W SalterScience200010846153No
249324101205.049.8124.9An automated method for finding molecular complexes in large protein interaction networks. Gary D Bader, Christopher W V HogueBMC Bioinformatics200312525261Yes
249412051205.033.4333.4Microbial influences in inflammatory bowel diseases. R Balfour SartorGastroenterology200818242222No
249524101205.095.2547.6Neutrophil recruitment and function in health and inflammation. Elzbieta Kolaczkowska, Paul KubesNat Rev Immunol201323435331No
249612041204.029.829.8Bcl-2 initiates a new category of oncogenes: regulators of cell death. S J KorsmeyerBlood19921498330No
249736121204.0125.9142.0Factor structure of the Barratt impulsiveness scale. J H Patton, M S Stanford, E S BarrattJ Clin Psychol19958778124Yes
249812041204.026.1826.2Dendritic cells: unique leukocyte populations which control the primary immune response. D N HartBlood19979345009No
249912041204.00.00.0Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. J M Van RossumArch Int Pharmacodyn Ther196313996119Yes
250036101203.363.6921.2A system for stable expression of short interfering RNAs in mammalian cells. Thijn R Brummelkamp, René Bernards, Reuven AgamiScience200211910072Yes
250124061203.048.1124.1Checkpoints: controls that ensure the order of cell cycle events. L H Hartwell, T A WeinertScience19892683079No
250212031203.029.6329.6Somatostatin and its receptor family. Y C PatelFront Neuroendocrinol199910433861No
250312031203.028.9729.0Oxidative stress in neurodegeneration: cause or consequence? Julie K AndersenNat Med200415298006No
250424041202.075.7237.9Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J E Hixson, D T VernierJ Lipid Res19902341813Yes
250524021201.098.4649.2Van der Waals heterostructures. A K Geim, I V GrigorievaNature201323887427Yes
250612001200.028.5628.6Growth factors and cancer. S A AaronsonScience19911659742No
250712001200.029.3629.4Reactive oxygen radicals in signaling and damage in the ischemic brain. P H ChanJ Cereb Blood Flow Metab200111149664No
250835991199.783.7427.9OrthoMCL: identification of ortholog groups for eukaryotic genomes. Li Li, Christian J Stoeckert, David S RoosGenome Res200312952885Yes
250911991199.027.4427.4Hybridization of denatured RNA transferred or dotted nitrocellulose paper. P S ThomasMethods Enzymol19836194404Yes
251011991199.037.0637.1Depression in late life: review and commentary. Dan G BlazerJ Gerontol A Biol Sci Med Sci200312634292No
251111991199.00.00.0The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. G A RoseBull World Health Organ196213974778Yes
251223971198.50.00.0Surgical risk as related to time of intervention in the repair of intracranial aneurysms. W E Hunt, R M HessJ Neurosurg19685635959Yes
251323971198.549.2724.6Gene silencing in cancer in association with promoter hypermethylation. James G Herman, Stephen B BaylinN Engl J Med200314627790No
251411981198.029.0729.1The path to ubiquitous and low-cost organic electronic appliances on plastic. Stephen R ForrestNature200415118718Yes
251523961198.062.7231.4Regulation mechanisms and signaling pathways of autophagy. Congcong He, Daniel J KlionskyAnnu Rev Genet200919653858No
251611971197.023.5423.5Mobile elements: drivers of genome evolution. Haig H KazazianScience200415016989No
251711971197.038.3538.4Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Thomas GrobnerNephrol Dial Transplant200616431890Yes
2518131661196.9462.742.1A new equation to estimate glomerular filtration rate. Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef CoreshAnn Intern Med200919414839Yes
251935871195.786.8228.9Dystrophin: the protein product of the Duchenne muscular dystrophy locus. E P Hoffman, R H Brown, L M KunkelCell19873319190Yes
252035871195.791.5730.5Functional porous coordination polymers. Susumu Kitagawa, Ryo Kitaura, Shin-ichiro NoroAngew Chem Int Ed Engl200415114565Yes
252123911195.563.6731.8Nanostructures in biodiagnostics. Nathaniel L Rosi, Chad A MirkinChem Rev200515826019No
252235861195.389.1629.7Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Christopher R Genovese, Nicole A Lazar, Thomas NicholsNeuroimage200211906227Yes
252311951195.059.2959.3ROC methodology in radiologic imaging. C E MetzInvest Radiol19863095258No
252411951195.048.5148.5Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. E H BeacheyJ Infect Dis19817014727No
252511951195.026.8726.9Prediction of protein cellular attributes using pseudo-amino acid composition. K C ChouProteins200111288174Yes
252623891194.561.1530.6Rising incidence of hepatocellular carcinoma in the United States. H B El-Serag, A C MasonN Engl J Med199910072408Yes
252711941194.030.9230.9Surrogate endpoints in clinical trials: definition and operational criteria. R L PrenticeStat Med19892727467Yes
252811941194.027.8827.9Transcriptional control of adipocyte formation. Stephen R FarmerCell Metab200617011499No
252923881194.096.9848.5PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. Daniel R Roe, Thomas E CheathamJ Chem Theory Comput201326583988Yes
253023871193.546.1623.1The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. T Maehama, J E DixonJ Biol Chem19989593664Yes
253111931193.033.8333.8Diversity of group types, regulation, and function of phospholipase A2. E A DennisJ Biol Chem19948175726No
253211931193.054.6554.6Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. P de LevaJ Biomech19968872282Yes
253311931193.026.1726.2The finer things in X-ray diffraction data collection. J W PflugrathActa Crystallogr D Biol Crystallogr199910531521Yes
253411911191.029.7729.8Hereditary cancer, oncogenes, and antioncogenes. A G KnudsonCancer Res19852983882Yes
253511911191.00.00.0Studies on phosphatidylcholine vesicles. Formation and physical characteristics. C HuangBiochemistry19695777332Yes
253611911191.029.6929.7Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. P KuzmicAnal Biochem19968660575Yes
253723821191.074.9137.5Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). Kathryn M Connor, Jonathan R T DavidsonDepress Anxiety200312964174Yes
253811911191.032.3632.4Plasmonics: merging photonics and electronics at nanoscale dimensions. Ekmel OzbayScience200616410515Yes
253983351190.7305.1643.6GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J SchünemannBMJ200818436948Yes
254023811190.564.5932.3Leukocyte-endothelial adhesion molecules. T M Carlos, J M HarlanBlood19947522621No
254123811190.566.8533.4Antibiotic resistance of bacteria in biofilms. P S Stewart, J W CostertonLancet200111463434No
254247621190.5100.5225.1Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. D D Sarbassov, David A Guertin, Siraj M Ali, David M SabatiniScience200515718470Yes
254383331190.4272.1538.9AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J OlsonJ Comput Chem200919399780Yes
254411901190.00.00.0Campylobacter enteritis: a "new" disease. M B SkirrowBr Med J1977871765Yes
254511901190.00.00.0Assay of intestinal disaccharidases. A DahlqvistAnal Biochem19685636962Yes
254611901190.045.5145.5Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. S H SafeCrit Rev Toxicol19948037844No
254711901190.039.139.1The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Artemis P SimopoulosExp Biol Med (Maywood)200818408140No
254811891189.043.443.4Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. R M PostAm J Psychiatry19921353322No
254911891189.045.0845.1Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. S KatzJ Am Geriatr Soc19836418786No
255011891189.021.3121.3Cancer susceptibility and the functions of BRCA1 and BRCA2. Ashok R VenkitaramanCell200211832208No
255111891189.00.00.0The cytoarchitectonic organization of the spinal cord in the cat. B RexedJ Comp Neurol195214946260Yes
255211891189.00.00.0An approximate distribution of estimates of variance components. F E SatterthwaiteBiometrics194620287815Yes
255323761188.00.00.0Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. J D Peuler, G A JohnsonLife Sci1977904439Yes
255411881188.00.00.0Displaced proximal humeral fractures. I. Classification and evaluation. C S NeerJ Bone Joint Surg Am19705455339Yes
255523761188.0123.8961.9A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. M Roland, R MorrisSpine (Phila Pa 1976)19836222486Yes
255623751187.555.0227.5Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. T Hunter, B M SeftonProc Natl Acad Sci U S A19806246487Yes
255711871187.037.9437.9Antioxidants in human health and disease. B HalliwellAnnu Rev Nutr19968839918No
255811871187.025.2825.3Caspase structure, proteolytic substrates, and function during apoptotic cell death. D W NicholsonCell Death Differ199910578171No
255923741187.063.1931.6Myocardial reperfusion injury. Derek M Yellon, Derek J HausenloyN Engl J Med200717855673No
256011861186.055.8455.8A cognitive approach to panic. D M ClarkBehav Res Ther19863741311Yes
256111861186.029.8529.9The neuropathology of schizophrenia. A critical review of the data and their interpretation. P J HarrisonBrain199910219775No
256211861186.027.227.2Long-term potentiation and memory. M A LynchPhysiol Rev200414715912No
256335581186.093.1531.1Wnt/beta-catenin signaling: components, mechanisms, and diseases. Bryan T MacDonald, Keiko Tamai, Xi HeDev Cell200919619488No
256411861186.038.3938.4Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Charles A DinarelloBlood201121304099No
256511841184.028.7428.7Intracellular protein topogenesis. G BlobelProc Natl Acad Sci U S A19806929499Yes
256611841184.033.5333.5The sympathetic control of blood pressure. Patrice G GuyenetNat Rev Neurosci200616760914No
256735501183.3107.2335.7The functional anatomy of basal ganglia disorders. R L Albin, A B Young, J B PenneyTrends Neurosci19892479133No
256811831183.038.1538.1The pathogenesis of sepsis. R C BoneAnn Intern Med19911872494No
256911831183.059.8159.8The clinical application of the biopsychosocial model. G L EngelAm J Psychiatry19807369396Yes
257011831183.031.3831.4Drug delivery and targeting. R LangerNature19989579855No
257111831183.022.8622.9Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Ricky W JohnstoneNat Rev Drug Discov200212120280No
257211831183.00.00.0The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. W G DuncombeClin Chim Acta196414122498Yes
257311821182.00.00.0Mutation selection and the natural history of cancer. J CairnsNature19751143315Yes
257423641182.056.7228.4Peroxisome proliferator-activated receptors: nuclear control of metabolism. B Desvergne, W WahliEndocr Rev199910529898No
257511821182.026.7726.8S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. R DonatoInt J Biochem Cell Biol200111390274No
257635461182.086.3828.8Global and societal implications of the diabetes epidemic. P Zimmet, K G Alberti, J ShawNature200111742409No
257723641182.059.5829.8Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Kornelia Polyak, Robert A WeinbergNat Rev Cancer200919262571No
257811811181.021.7621.8The molecular motor toolbox for intracellular transport. Ronald D ValeCell200312600311No
257935431181.076.5725.5Calcium signalling: dynamics, homeostasis and remodelling. Michael J Berridge, Martin D Bootman, H Llewelyn RoderickNat Rev Mol Cell Biol200312838335No
258047221180.5110.2527.6A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry SharplessAngew Chem Int Ed Engl200212203546Yes
258123611180.598.5849.3The future of immune checkpoint therapy. Padmanee Sharma, James P AllisonScience201525838373No
258211801180.044.6944.7A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. S T TiffanyPsychol Rev19902186423No
258323601180.0144.0572.0The amyloid hypothesis of Alzheimer's disease at 25 years. Dennis J Selkoe, John HardyEMBO Mol Med201627025652No
258435391179.776.6725.6Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Michael J Rust, Mark Bates, Xiaowei ZhuangNat Methods200616896339Yes
258523591179.564.4732.2Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. M A Pfeffer, E BraunwaldCirculation19902138525No
258611791179.026.9526.9Nuclear factor-kappaB: the enemy within. Bharat B AggarwalCancer Cell200415380510No
258747151178.8128.6332.2Microbial ecology: human gut microbes associated with obesity. Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I GordonNature200617183309Yes
258835361178.798.3232.8Molecular characterization of a peripheral receptor for cannabinoids. S Munro, K L Thomas, M Abu-ShaarNature19937689702Yes
258923571178.561.4530.7Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Uwe-Karsten Hanisch, Helmut KettenmannNat Neurosci200717965659No
259058921178.4113.9222.8Crystal structure of the nucleosome core particle at 2.8 A resolution. K Luger, A W Mäder, R K Richmond, D F Sargent, T J RichmondNature19979305837Yes
259135351178.3102.4534.1Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. H King, R E Aubert, W H HermanDiabetes Care19989727886Yes
259211781178.00.00.0Measurement of feelings using visual analogue scales. R C AitkenProc R Soc Med19694899510No
259311781178.024.5724.6Morphogenetic roles of classic cadherins. M TakeichiCurr Opin Cell Biol19958573335No
259411781178.022.1422.1Kinesin and dynein superfamily proteins and the mechanism of organelle transport. N HirokawaScience19989438838No
2595164901177.9363.6126.0Crystallography & NMR system: A new software suite for macromolecular structure determination. A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L WarrenActa Crystallogr D Biol Crystallogr19989757107Yes
259623551177.550.525.2ERBB receptors and cancer: the complexity of targeted inhibitors. Nancy E Hynes, Heidi A LaneNat Rev Cancer200515864276No
259735321177.3147.4549.1Multiple imputation using chained equations: Issues and guidance for practice. Ian R White, Patrick Royston, Angela M WoodStat Med201121225900Yes
259835311177.090.4730.2LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. A C Wallace, R A Laskowski, J M ThorntonProtein Eng19957630882Yes
259911771177.029.429.4Huntington's disease. Francis O WalkerLancet200717240289No
260035291176.373.9324.6Large-scale analysis of the yeast proteome by multidimensional protein identification technology. M P Washburn, D Wolters, J R YatesNat Biotechnol200111231557Yes
260111761176.041.0441.0The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. N M KaplanArch Intern Med19892662932No
260211761176.041.4341.4Inhibition and facilitation of nucleic acid amplification. I G WilsonAppl Environ Microbiol19979327537No
260311761176.034.4234.4Varieties of impulsivity. J L EvendenPsychopharmacology (Berl)199910550486No
260411751175.028.5328.5Rapid and sensitive sequence comparison with FASTP and FASTA. W R PearsonMethods Enzymol19902156132Yes
260511751175.053.9954.0Biomaterial-centered infection: microbial adhesion versus tissue integration. A G GristinaScience19873629258Yes
260623501175.050.6125.3Tumorigenesis and the angiogenic switch. Gabriele Bergers, Laura E BenjaminNat Rev Cancer200312778130No
260711751175.00.00.0Histological demonstration of mucin after periodic acid. J F A McMANUSNature194620995486Yes
260823491174.564.9732.5Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. Gerard Talavera, Jose CastresanaSyst Biol200717654362Yes
260911741174.036.7836.8Biosynthesis and metabolism of endothelium-derived nitric oxide. L J IgnarroAnnu Rev Pharmacol Toxicol19902188578No
261011741174.039.6739.7Interleukin-1 and the pathogenesis of the acute-phase response. C A DinarelloN Engl J Med19846208485No
261123481174.064.132.0A review of central 5-HT receptors and their function. N M Barnes, T SharpNeuropharmacology199910462127No
261223471173.577.3938.7Accessories to the crime: functions of cells recruited to the tumor microenvironment. Douglas Hanahan, Lisa M CoussensCancer Cell201222439926No
261311731173.052.8652.9Presynaptic regulation of the release of catecholamines. S Z LangerPharmacol Rev19806267618Yes
261435191173.0110.1536.7Dose translation from animal to human studies revisited. Shannon Reagan-Shaw, Minakshi Nihal, Nihal AhmadFASEB J200817942826Yes
261511731173.064.764.7Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. Kevin A HallgrenTutor Quant Methods Psychol201222833776Yes
261623461173.096.0848.0Neoantigens in cancer immunotherapy. Ton N Schumacher, Robert D SchreiberScience201525838375No
261723451172.560.3230.2Microenvironmental regulation of metastasis. Johanna A Joyce, Jeffrey W PollardNat Rev Cancer200919279573No
261823441172.091.6445.8Malondialdehyde determination as index of lipid peroxidation. H H Draper, M HadleyMethods Enzymol19902233309Yes
261911721172.036.2836.3The mysteries of lipoprotein(a). G UtermannScience19892530631No
262011721172.034.7734.8Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. W SieghartPharmacol Rev19957568326No
262135161172.086.528.8Functional diversity of helper T lymphocytes. A K Abbas, K M Murphy, A SherNature19968893001No
262211721172.00.00.0A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. J B BrownBiochem J195514389222Yes
262311721172.028.4128.4Pathways of oxidative damage. James A ImlayAnnu Rev Microbiol200314527285No
262411721172.039.5139.5phangorn: phylogenetic analysis in R. Klaus Peter SchliepBioinformatics201121169378Yes
262511721172.075.2975.3Abiotic Stress Signaling and Responses in Plants. Jian-Kang ZhuCell201627716505No
2626105331170.3357.8839.8A novel potent vasoconstrictor peptide produced by vascular endothelial cells. M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T MasakiNature19882451132Yes
262711701170.00.00.0Nontuberculous mycobacteria and associated diseases. E WolinskyAm Rev Respir Dis1979369415No
262811701170.049.0749.1Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). S SafeCrit Rev Toxicol19902124811No
262911701170.026.1226.1The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. S J CollinsBlood19873311197No
263023401170.095.4847.7Rapid procedure for detection and isolation of large and small plasmids. C I Kado, S T LiuJ Bacteriol19817009583Yes
263111701170.023.5523.6Lipid rafts: elusive or illusive? Sean MunroCell200314622593No
263223401170.099.7549.9The M1 and M2 paradigm of macrophage activation: time for reassessment. Fernando O Martinez, Siamon GordonF1000Prime Rep201424669294No
263311691169.036.3136.3Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. E N BergmanPhysiol Rev19902181501No
263423381169.054.8227.4Can the pharmaceutical industry reduce attrition rates? Ismail Kola, John LandisNat Rev Drug Discov200415286737No
263511681168.042.242.2Plasma perspective on strong field multiphoton ionization. CorkumPhys Rev Lett199310054556Yes
263611681168.029.6929.7Optimal experimental design for event-related fMRI. A M DaleHum Brain Mapp199910524601Yes
263723361168.047.9724.0Molecular chaperones in the cytosol: from nascent chain to folded protein. F Ulrich Hartl, Manajit Hayer-HartlScience200211884745No
263811681168.027.6627.7Liver fibrosis -- from bench to bedside. Scott L FriedmanJ Hepatol200312591185No
263923351167.50.00.0The low-density lipoprotein pathway and its relation to atherosclerosis. J L Goldstein, M S BrownAnnu Rev Biochem1977197883No
264035021167.371.7623.9The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Fabio Martinon, Kimberly Burns, Jürg TschoppMol Cell200212191486Yes
264111671167.036.5436.5Chronic disease management: what will it take to improve care for chronic illness? E H WagnerEff Clin Pract199810345255No
264223331166.566.8933.4Alternative activation of macrophages: mechanism and functions. Siamon Gordon, Fernando O MartinezImmunity201020510870No
264311661166.029.5629.6Primate anterior cingulate cortex: where motor control, drive and cognition interface. T PausNat Rev Neurosci200111389475No
264458271165.4192.2138.4Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L WitztumN Engl J Med19892648148No
264523301165.045.8922.9Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. C W Greider, E H BlackburnCell19853907856Yes
264611651165.037.7937.8Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. J J GrossJ Pers Soc Psychol19989457784Yes
264711651165.026.6526.6Translating cell biology into therapeutic advances in Alzheimer's disease. D J SelkoeNature199910392577No
264811651165.00.00.0A sensitive method for the assay of 5-hydroxytryptamine. J R VaneBr J Pharmacol Chemother195713460242Yes
264911651165.00.00.0The generalisation of student's problems when several different population variances are involved. B L WelchBiometrika194720287819Yes
265069861164.3136.1922.7Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T TuschlNature200111373684Yes
265111641164.021.3421.3Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. D HanahanNature19852986015Yes
265211641164.031.3831.4The lipocalin protein family: structure and function. D R FlowerBiochem J19968761444No
265311641164.031.0431.0Psychological and neural mechanisms of the affective dimension of pain. D D PriceScience200010846154No
265411641164.019.6419.6Themes and variations on ubiquitylation. A M WeissmanNat Rev Mol Cell Biol200111265246No
265511641164.031.8731.9Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. G L SemenzaOncogene201019946328No
265634911163.70.00.0Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. A DeLean, P J Munson, D RodbardAm J Physiol1978686171Yes
265734911163.70.00.0Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. A L Shapiro, E Viñuela, J V MaizelBiochem Biophys Res Commun19674861258Yes
265834911163.7101.2633.8Nitric oxide and peroxynitrite in health and disease. Pál Pacher, Joseph S Beckman, Lucas LiaudetPhysiol Rev200717237348No
265911631163.061.4961.5Rating scales to assess depression in school-aged children. M KovacsActa Paedopsychiatr19817025571Yes
266011631163.030.9831.0Wound healing and its impairment in the diabetic foot. Vincent FalangaLancet200516291068No
266123251162.50.00.0Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. R W Butcher, E W SutherlandJ Biol Chem196213875173Yes
266211621162.00.00.0Experience from a multicentre stroke register: a preliminary report. S HatanoBull World Health Organ19761088404Yes
266334861162.072.5224.2Cellular survival: a play in three Akts. S R Datta, A Brunet, M E GreenbergGenes Dev199910579998No
266411611161.031.0731.1Pain and emotion interactions in subregions of the cingulate gyrus. Brent A VogtNat Rev Neurosci200515995724No
266523211160.5158.3479.2Facial nerve grading system. J W House, D E BrackmannOtolaryngol Head Neck Surg19853921901Yes
266611601160.00.00.0Optimal foraging, the marginal value theorem. E L CharnovTheor Popul Biol19761273796Yes
266711601160.00.00.0Presynaptic regulation of catecholamine release. S Z LangerBiochem Pharmacol19744617579No
266811601160.033.6733.7Papillary and follicular thyroid carcinoma. M J SchlumbergerN Engl J Med19989445411No
266911601160.028.1528.1Matrix proteoglycans: from molecular design to cellular function. R V IozzoAnnu Rev Biochem19989759499No
267023201160.062.9331.5Imaging cognition II: An empirical review of 275 PET and fMRI studies. R Cabeza, L NybergJ Cogn Neurosci200010769304No
267111601160.036.0936.1Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. Felix KratzJ Control Release200818582981No
267223191159.597.5548.8Reading senseless sentences: brain potentials reflect semantic incongruity. M Kutas, S A HillyardScience19807350657Yes
267346371159.2101.5925.4Interleukin-10 and the interleukin-10 receptor. K W Moore, R de Waal Malefyt, R L Coffman, A O'GarraAnnu Rev Immunol200111244051No
267411591159.022.3122.3Contingent genetic regulatory events in T lymphocyte activation. G R CrabtreeScience19892783497Yes
267511591159.045.5245.5Translating social ecological theory into guidelines for community health promotion. D StokolsAm J Health Promot199610159709No
267611591159.032.3332.3The biochemistry and medical significance of the flavonoids. Bent H HavsteenPharmacol Ther200212453566No
267723181159.059.2929.6Drug delivery systems: entering the mainstream. Theresa M Allen, Pieter R CullisScience200415031496Yes
267811591159.00.00.0A simple objective technique for measuring flexibility in thinking. E A BergJ Gen Psychol194818889466Yes
267911591159.039.4239.4Breakthrough of the year 2013. Cancer immunotherapy. Jennifer Couzin-FrankelScience201324357284No
268023171158.5134.5967.3mTOR Signaling in Growth, Metabolism, and Disease. Robert A Saxton, David M SabatiniCell201728283069No
268146331158.2165.4341.4Guidelines for the process of cross-cultural adaptation of self-report measures. D E Beaton, C Bombardier, F Guillemin, M B FerrazSpine (Phila Pa 1976)200011124735No
268223161158.070.1435.1Recent advances in the phencyclidine model of schizophrenia. D C Javitt, S R ZukinAm J Psychiatry19911654746No
268311581158.046.7446.7Social phobia. M R LiebowitzMod Probl Pharmacopsychiatry19872885745Yes
268411581158.030.6230.6Pathogenesis of dengue: challenges to molecular biology. S B HalsteadScience19883277268No
268511581158.00.00.0The concept of immunological surveillance. F M BurnetProg Exp Tumor Res19704921480No
268611581158.035.7635.8Cytokinesis-block micronucleus cytome assay. Michael FenechNat Protoc200717546000Yes
268711571157.00.00.0RNA metabolism in the HeLa cell nucleus. S PenmanJ Mol Biol19665961144Yes
268811571157.045.2345.2Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. H V GelboinPhysiol Rev19807001511No
268923141157.051.425.7Lymphocyte homing and homeostasis. E C Butcher, L J PickerScience19968600538No
269011571157.025.1325.1Platelets in atherothrombosis. Zaverio M RuggeriNat Med200212411949No
269123141157.075.0837.5An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. O Johnell, J A KanisOsteoporos Int200616983459Yes
269211571157.038.2438.2Mitochondria and cancer. Douglas C WallaceNat Rev Cancer201223001348No
269334701156.70.00.0The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. G Blessed, B E Tomlinson, M RothBr J Psychiatry19685662937Yes
269423121156.00.00.0Plasminogen: purification from human plasma by affinity chromatography. D G Deutsch, E T MertzScience19705475635Yes
269511561156.027.7427.7Metastatic bone disease: clinical features, pathophysiology and treatment strategies. R E ColemanCancer Treat Rev200111417967No
269623111155.50.00.0Quantitative determination of serum triglycerides by the use of enzymes. G Bucolo, H DavidClin Chem19734703655Yes
269723101155.052.3826.2The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. P M Sharp, W H LiNucleic Acids Res19873547335Yes
269811551155.073.6873.7Impingement lesions. C S NeerClin Orthop Relat Res19836825348Yes
269911541154.00.00.0Selective coronary arteriography. I. A percutaneous transfemoral technic. M P JudkinsRadiology19676048074Yes
270011541154.030.0930.1Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. G BodenDiabetes19978971073No
270111541154.025.9325.9Molecular physiology of low-voltage-activated t-type calcium channels. Edward Perez-ReyesPhysiol Rev200312506128No
270211541154.037.1337.1Endometriosis. Serdar E BulunN Engl J Med200919144942No
270311541154.048.9348.9Cytokines in inflammatory bowel disease. Markus F NeurathNat Rev Immunol201424751956No
270434611153.7125.4141.8Rehospitalizations among patients in the Medicare fee-for-service program. Stephen F Jencks, Mark V Williams, Eric A ColemanN Engl J Med200919339721Yes
270523071153.50.00.0Construct validity in psychological tests. L J Cronbach, P E MeehlPsychol Bull195513245896Yes
270634601153.30.00.0High resolution two-dimensional electrophoresis of basic as well as acidic proteins. P Z O'Farrell, H M Goodman, P H O'FarrellCell197723215Yes
270734601153.385.7228.6Tissue cells feel and respond to the stiffness of their substrate. Dennis E Discher, Paul Janmey, Yu-Li WangScience200516293750No
270811531153.032.0732.1Mitochondrial fusion and fission in cell life and death. Benedikt WestermannNat Rev Mol Cell Biol201021102612No
270969141152.3184.1330.7Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat RoblesBioinformatics200516081474Yes
271011521152.025.9626.0Cadherins: a molecular family important in selective cell-cell adhesion. M TakeichiAnnu Rev Biochem19902197976No
271111521152.031.9131.9Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. U MitzdorfPhysiol Rev19853880898No
271223041152.064.5732.3Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Ajay Kumar Gupta, Mona GuptaBiomaterials200515626447No
271323031151.566.2333.1Increasing incidence of thyroid cancer in the United States, 1973-2002. Louise Davies, H Gilbert WelchJAMA200616684987Yes
2714103611151.2669.0274.3Cancer statistics in China, 2015. Wanqing Chen, Rongshou Zheng, Peter D Baade, Siwei Zhang, Hongmei Zeng, Freddie Bray, Ahmedin Jemal, Xue Qin Yu, Jie HeCA Cancer J Clin201626808342Yes
271511511151.032.5632.6How brains beware: neural mechanisms of emotional attention. Patrik VuilleumierTrends Cogn Sci200516289871Yes
271623001150.00.00.0Solubilization of membranes by detergents. A Helenius, K SimonsBiochim Biophys Acta19751091302No
271711501150.034.1534.1The fetal and infant origins of adult disease. D J BarkerBMJ19902252919No
271811501150.025.3725.4The roles of intracellular protein-degradation pathways in neurodegeneration. David C RubinszteinNature200617051204No
271911491149.00.00.0Biogenic amines and the states of sleep. M JouvetScience19694303225No
272011491149.026.8926.9Mitochondrial transport of cations: channels, exchangers, and permeability transition. P BernardiPhysiol Rev199910508231No
272111491149.031.631.6Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Earl S FordDiabetes Care200515983333No
272211491149.026.026.0Neuroligins and neurexins link synaptic function to cognitive disease. Thomas C SüdhofNature200818923512No
272311491149.059.9560.0Nonalcoholic fatty liver disease: a systematic review. Mary E RinellaJAMA201526057287No
272411491149.089.4789.5Understanding Bland Altman analysis. Davide GiavarinaBiochem Med (Zagreb)201526110027No
272511471147.00.00.0Diffusion-in-gel methods for immunological analysis. II. O OuchterlonyProg Allergy196214482809Yes
272611471147.023.2923.3IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Yong-Jun LiuAnnu Rev Immunol200515771572No
272722941147.081.240.6Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Riccardo Lencioni, Josep M LlovetSemin Liver Dis201020175033No
272822931146.555.2627.6Emerging roles of caspase-3 in apoptosis. A G Porter, R U JänickeCell Death Differ199910200555No
272922921146.046.9523.5A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. N C Andrews, D V FallerNucleic Acids Res19912041787Yes
273011461146.040.3540.4Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. A J AlpertJ Chromatogr19902324207Yes
273122911145.50.00.0Growth of a rat neuroblastoma cell line in serum-free supplemented medium. J E Bottenstein, G H SatoProc Natl Acad Sci U S A1979284369Yes
273222911145.569.6134.8A cognitive model of posttraumatic stress disorder. A Ehlers, D M ClarkBehav Res Ther200010761279No
273391641145.5283.535.4The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. Ziad S Nasreddine, Natalie A Phillips, Valérie Bédirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard ChertkowJ Am Geriatr Soc200515817019Yes
273411451145.00.00.0Radioimmunological determination of human C-peptide in serum. L G HedingDiabetologia19751239396Yes
273511451145.00.00.0Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. D B ClewellJ Bacteriol19724336693Yes
273611451145.032.4532.5DNA topoisomerases. M GellertAnnu Rev Biochem19816267993No
273734351145.0101.433.8Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Günter Oberdörster, Eva Oberdörster, Jan OberdörsterEnviron Health Perspect200516002369No
273811451145.025.4225.4Solving structures of protein complexes by molecular replacement with Phaser. Airlie J McCoyActa Crystallogr D Biol Crystallogr200717164524Yes
273911451145.032.4432.4Plant productivity and environment. J S BoyerScience198217808529Yes
274011441144.020.720.7Stem cells: units of development, units of regeneration, and units in evolution. I L WeissmanCell200010647940No
274134311143.70.00.0Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. G M Wahl, M Stern, G R StarkProc Natl Acad Sci U S A1979291033Yes
274257181143.6223.844.8The hallmarks of aging. Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido KroemerCell201323746838No
274311431143.00.00.0Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J O HolloszyJ Biol Chem19674290225Yes
274411431143.030.8130.8Hydrogen sulphide and its therapeutic potential. Csaba SzabóNat Rev Drug Discov200717948022No
274522851142.549.7224.9Functions of lipid rafts in biological membranes. D A Brown, E LondonAnnu Rev Cell Dev Biol19989891780No
274611421142.034.4934.5Effect of anoxia on ion distribution in the brain. A J HansenPhysiol Rev19853880896No
274722841142.048.7824.4Toll-like receptors in the induction of the innate immune response. A Aderem, R J UlevitchNature200010963608No
274811421142.036.8636.9Risk and maintenance factors for eating pathology: a meta-analytic review. Eric SticePsychol Bull200212206196No
274922831141.592.8746.4The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. R Näätänen, T PictonPsychophysiology19873615753Yes
275034231141.069.7623.3Predicting coiled coils from protein sequences. A Lupas, M Van Dyke, J StockScience19912031185Yes
275111411141.029.5729.6Non-Smad pathways in TGF-beta signaling. Ying E ZhangCell Res200919114990No
275234211140.377.6725.9Adjusting batch effects in microarray expression data using empirical Bayes methods. W Evan Johnson, Cheng Li, Ariel RabinovicBiostatistics200716632515Yes
275311401140.077.6277.6The problem of rigor in qualitative research. M SandelowskiANS Adv Nurs Sci19863083765Yes
275422791139.583.1741.6How good are my data and what is the resolution? Philip R Evans, Garib N MurshudovActa Crystallogr D Biol Crystallogr201323793146Yes
275511391139.00.00.0Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. M M WeiserJ Biol Chem19734698230Yes
275611391139.00.00.0Pathologic anatomy of the pancreas in juvenile diabetes mellitus. W GeptsDiabetes19655318831Yes
275711391139.019.7619.8Mitotic kinases as regulators of cell division and its checkpoints. E A NiggNat Rev Mol Cell Biol200111413462No
275811381138.00.00.0Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. S Z LangerBr J Pharmacol197720190No
275922761138.075.8937.9Atomic structure and chemistry of human serum albumin. X M He, D C CarterNature19921630489Yes
276022761138.071.3535.7Role of oxidized low density lipoprotein in atherogenesis. J L Witztum, D SteinbergJ Clin Invest19911752940No
276111381138.00.00.0Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. R J PenningtonBiochem J196113734134Yes
276211381138.00.00.0A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. R D HotchkissArch Biochem194818921848Yes
276311381138.00.00.0A Protection Motivation Theory of Fear Appeals and Attitude Change1. Ronald W RogersJ Psychol197528136248Yes
276434131137.772.8624.3Toll-like receptors: critical proteins linking innate and acquired immunity. S Akira, K Takeda, T KaishoNat Immunol200111477402No
276522751137.562.331.1Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Barry J Everitt, Trevor W RobbinsNat Neurosci200516251991No
276645481137.0109.3727.3Base-calling of automated sequencer traces using phred. I. Accuracy assessment. B Ewing, L Hillier, M C Wendl, P GreenGenome Res19989521921Yes
276711371137.026.8826.9Brain tumors. L M DeAngelisN Engl J Med200111150363No
276834101136.70.00.0Cytochemical identification of monocytes and granulocytes. L T Yam, C Y Li, W H CrosbyAm J Clin Pathol19715549896Yes
276922731136.50.00.0Radiological demarcation of cemented sockets in total hip replacement. J G DeLee, J CharnleyClin Orthop Relat Res1976991504Yes
277011361136.022.3722.4Mechanisms and consequences of activation of protein kinase B/Akt. J DownwardCurr Opin Cell Biol19989561851No
277111361136.034.3934.4The structure of common mental disorders. R F KruegerArch Gen Psychiatry199910530634Yes
277222711135.50.00.0Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. R B Gustilo, J T AndersonJ Bone Joint Surg Am1976773941Yes
277311351135.00.00.0An approach for the treatment of penile carcinoma. R M CabanasCancer1977837331Yes
277411351135.00.00.0An improved fluorometric assay for DNA. R T HinegardnerAnal Biochem19715544593Yes
277511351135.027.1127.1The prefrontal cortex and cognitive control. E K MillerNat Rev Neurosci200011252769No
277611351135.00.00.0Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. A B StavitskyJ Immunol195413163409Yes
277768091134.8221.7737.0A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle CharpentierScience201222745249Yes
277822681134.00.00.0Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. J D McGhee, P H von HippelJ Mol Biol19744416620Yes
277911341134.00.00.0Metabolic stability and epigenesis in randomly constructed genetic nets. S A KauffmanJ Theor Biol19695803332Yes
278011341134.00.00.0Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. A R MidgleyEndocrinology19665950482Yes
278122681134.0143.4771.7A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. E S Grood, W J SuntayJ Biomech Eng19836865355Yes
278211341134.034.934.9Low-molecular-weight heparins. J I WeitzN Engl J Med19979278467No
278311341134.025.4525.4Microglia as a source and target of cytokines. Uwe-Karsten HanischGlia200212379902No
278411341134.039.8839.9Apoptosis in cancer: from pathogenesis to treatment. Rebecca S Y WongJ Exp Clin Cancer Res201121943236No
278545351133.8133.5933.4Place navigation impaired in rats with hippocampal lesions. R G Morris, P Garrud, J N Rawlins, J O'KeefeNature19827088155Yes
278622671133.544.822.4Multiple nuclear factors interact with the immunoglobulin enhancer sequences. R Sen, D BaltimoreCell19863091258Yes
278711331133.025.5325.5Physiological concentrations of purines and pyrimidines. T W TrautMol Cell Biochem19947877593No
278822661133.051.3925.7Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Eugenia E Calle, Rudolf KaaksNat Rev Cancer200415286738No
278911331133.030.6530.6Polymer conjugates as anticancer nanomedicines. Ruth DuncanNat Rev Cancer200616900224No
279011331133.00.00.0pA, a new scale for the measurement of drug antagonism. H O SchildBr J Pharmacol Chemother194720258355Yes
279111321132.036.4936.5Molecular biology of steroid hormone synthesis. W L MillerEndocr Rev19883061784No
279211321132.024.424.4Stem cells in the central nervous system. R McKayScience19979082987No
279311321132.026.0126.0Recognition and processing of ubiquitin-protein conjugates by the proteasome. Daniel FinleyAnnu Rev Biochem200919489727No
279422631131.541.920.9Stats: transcriptional control and biological impact. David E Levy, J E DarnellNat Rev Mol Cell Biol200212209125No
279545251131.2112.0228.0Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. H Nielsen, J Engelbrecht, S Brunak, G von HeijneProtein Eng19979051728Yes
279622621131.064.132.0Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. R G Phillips, J E LeDouxBehav Neurosci19921590953Yes
279711311131.040.8340.8The LMS method for constructing normalized growth standards. T J ColeEur J Clin Nutr19902354692Yes
279833911130.388.129.4Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. C R Woese, O Kandler, M L WheelisProc Natl Acad Sci U S A19902112744Yes
279911301130.032.0532.0The induction of pain: an integrative review. M J MillanProg Neurobiol19999987804No
280022601130.064.2632.1Meeting of minds: the medial frontal cortex and social cognition. David M Amodio, Chris D FrithNat Rev Neurosci200616552413No
280122581129.066.7333.4Excitatory amino acids as a final common pathway for neurologic disorders. S A Lipton, P A RosenbergN Engl J Med19947905600No
280211291129.031.5231.5Neural simulation of action: a unifying mechanism for motor cognition. M JeannerodNeuroimage200111373140No
280311291129.026.1826.2Neurobiology of Pavlovian fear conditioning. S MarenAnnu Rev Neurosci200111520922No
280422571128.561.5330.8Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. M J Casadaban, S N CohenJ Mol Biol19806997493Yes
280511281128.058.5758.6Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. Anna Maria CarlssonPain19836602967Yes
280611281128.026.8726.9Production of recombinant protein therapeutics in cultivated mammalian cells. Florian M WurmNat Biotechnol200415529164No
280711281128.052.5652.6Working memory: theories, models, and controversies. Alan BaddeleyAnnu Rev Psychol201221961947No
280811281128.041.8741.9The role of autophagy in neurodegenerative disease. Ralph A NixonNat Med201323921753No
280911271127.033.9934.0Unstable angina. A classification. E BraunwaldCirculation19892752565Yes
281011271127.043.4143.4On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. D CollenThromb Haemost19806450468No
281111271127.026.7426.7Amyloid, the presenilins and Alzheimer's disease. J HardyTrends Neurosci19979106355No
281211271127.00.00.0On the law of effect. R J HerrnsteinJ Exp Anal Behav197016811440Yes
281311261126.033.8833.9Determinants of tumor blood flow: a review. R K JainCancer Res19883282647No
281422511125.548.5824.3Atherosclerosis. the road ahead. C K Glass, J L WitztumCell200111239408No
281522511125.5104.0952.0Alginate: properties and biomedical applications. Kuen Yong Lee, David J MooneyProg Polym Sci201222125349Yes
281611251125.028.7328.7Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. I J FidlerCancer Res19901698118Yes
281722501125.00.00.0Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. L M Siegel, K J MontyBiochim Biophys Acta19665329026Yes
281822501125.00.00.0Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. H H Ussing, K ZerahnActa Physiol Scand195114868510Yes
281933751125.0164.254.7Scoping studies: advancing the methodology. Danielle Levac, Heather Colquhoun, Kelly K O'BrienImplement Sci201020854677Yes
282022491124.552.1326.1Toll-like receptors in innate immunity. Kiyoshi Takeda, Shizuo AkiraInt Immunol200515585605No
282133731124.378.3126.1Hepatocellular carcinoma. Josep M Llovet, Andrew Burroughs, Jordi BruixLancet200314667750No
282211241124.031.031.0Diseases of the mitochondrial DNA. D C WallaceAnnu Rev Biochem19921497308No
282311241124.00.00.06-Hydroxy-dopamine induced degeneration of central monoamine neurons. U UngerstedtEur J Pharmacol19685718510Yes
282411241124.022.3622.4Regulation of transcription by MAP kinase cascades. R TreismanCurr Opin Cell Biol19968791420No
282511241124.040.8340.8The amazing osteocyte. Lynda F BonewaldJ Bone Miner Res201121254230No
282611241124.028.5628.6Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. Christof M NiemeyerAngew Chem Int Ed Engl200129712109No
282711231123.00.00.0Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J AltmanJ Comp Neurol19695361244Yes
282811231123.040.9841.0Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. W A CatterallAnnu Rev Pharmacol Toxicol19806247957No
282911231123.030.4430.4The chromosomal basis of human neoplasia. J J YunisScience19836336310Yes
283022461123.062.3331.2Epidemiology and outcomes of osteoporotic fractures. Steven R Cummings, L Joseph MeltonLancet200212049882No
283122461123.064.9332.5The cognitive control of emotion. Kevin N Ochsner, James J GrossTrends Cogn Sci200515866151No
283211231123.032.4932.5Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Antoine BecharaNat Neurosci200516251988No
283311231123.025.9726.0Human natural killer cells. Michael A CaligiuriBlood200818650461No
283411231123.050.8150.8α-band oscillations, attention, and controlled access to stored information. Wolfgang KlimeschTrends Cogn Sci201223141428No
283511221122.026.6126.6Allelic discrimination using fluorogenic probes and the 5' nuclease assay. K J LivakGenet Anal199910084106Yes
283611221122.031.5231.5Internal models for motor control and trajectory planning. M KawatoCurr Opin Neurobiol199910607637No
283711221122.023.423.4Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. Harold F DvorakJ Clin Oncol200212409337No
283811221122.030.6630.7Q-ball imaging. David S TuchMagn Reson Med200415562495Yes
283911221122.029.1129.1Overview of general physiologic features and functions of vitamin D. Hector F DeLucaAm J Clin Nutr200415585789No
284011211121.045.945.9Bone "mass" and the "mechanostat": a proposal. H M FrostAnat Rec19873688455Yes
284111201120.031.5831.6Normalization of cell responses in cat striate cortex. D J HeegerVis Neurosci19921504027Yes
284244801120.0102.3525.6Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. J E Walker, M Saraste, M J Runswick, N J GayEMBO J19826329717Yes
284311201120.033.2133.2Cell surface interactions with extracellular materials. K M YamadaAnnu Rev Biochem19836351729No
284411201120.029.5129.5Neural systems for recognizing emotion. Ralph AdolphsCurr Opin Neurobiol200212015233No
284511201120.034.2834.3High prevalence of vitamin D inadequacy and implications for health. Michael F HolickMayo Clin Proc200616529140No
284611201120.00.00.0Intra-sexual selection in Drosophila. A J BatemanHeredity (Edinb)194818103134Yes
284722391119.566.9733.5Nitric oxide synthases in mammals. R G Knowles, S MoncadaBiochem J19947510950No
284811191119.033.7533.8Reducing children's television viewing to prevent obesity: a randomized controlled trial. T N RobinsonJAMA199910546696Yes
284944751118.8104.9726.2SCOP: a structural classification of proteins database for the investigation of sequences and structures. A G Murzin, S E Brenner, T Hubbard, C ChothiaJ Mol Biol19957723011Yes
285033561118.785.1228.4Evolution and functions of long noncoding RNAs. Chris P Ponting, Peter L Oliver, Wolf ReikCell200919239885No
285111181118.047.247.2A cochlear frequency-position function for several species--29 years later. D D GreenwoodJ Acoust Soc Am19902373794Yes
285211181118.00.00.0Voluntary strength and fatigue. P A MertonJ Physiol195413152698Yes
285322351117.545.0722.5Proliferation, cell cycle and apoptosis in cancer. G I Evan, K H VousdenNature200111357141No
285411171117.023.9223.9Mutator phenotype may be required for multistage carcinogenesis. L A LoebCancer Res19912039987No
285511171117.023.6623.7The lasso method for variable selection in the Cox model. R TibshiraniStat Med19979044528Yes
285611171117.023.5723.6Basement membranes: structure, assembly and role in tumour angiogenesis. Raghu KalluriNat Rev Cancer200312778132No
285711171117.00.00.0The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. R E Hope-SimpsonProc R Soc Med196514267505Yes
285822331116.544.2622.1NF-kappaB at the crossroads of life and death. Michael Karin, Anning LinNat Immunol200211875461No
285978141116.3161.4923.1Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P SpeedBiostatistics200312925520Yes
286011161116.035.0135.0Protein damage and degradation by oxygen radicals. I. general aspects. K J DaviesJ Biol Chem19873036875Yes
286111161116.0104.19104.2The analysis of errors in orthodontic measurements. W J HoustonAm J Orthod19836573846Yes
286211161116.022.1122.1Microarray data normalization and transformation. John QuackenbushNat Genet200212454644No
286311161116.00.00.0Preliminary Trial Of Carisoprodol In Multiple Sclerosis. B AshworthPractitioner196414143329Yes
286422311115.564.0632.0Ageing and Parkinson's disease: substantia nigra regional selectivity. J M Fearnley, A J LeesBrain19911933245Yes
286511151115.041.6341.6The P300 wave of the human event-related potential. T W PictonJ Clin Neurophysiol19921464675No
286611151115.027.7427.7Metabolism and functions of glutathione in brain. R DringenProg Neurobiol200010880854No
286711141114.00.00.0Cytoprotection by prostaglandins. A RobertGastroenterology197938173Yes
286811141114.033.8133.8The Hospital Anxiety And Depression Scale. R Philip SnaithHealth Qual Life Outcomes200312914662Yes
286911141114.036.3536.4Delirium in older persons. Sharon K InouyeN Engl J Med200616540616No
287044551113.8111.5227.9Autophagy fights disease through cellular self-digestion. Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J KlionskyNature200818305538No
287122261113.050.9325.5Adaptive protein evolution at the Adh locus in Drosophila. J H McDonald, M KreitmanNature19911904993Yes
287222261113.097.648.8Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. P R Hunter, M A GastonJ Clin Microbiol19883069867Yes
287311131113.040.9541.0Synopsis of some recent tactical application of bioisosteres in drug design. Nicholas A MeanwellJ Med Chem201121413808Yes
287433381112.7107.435.8MR diffusion tensor spectroscopy and imaging. P J Basser, J Mattiello, D LeBihanBiophys J19948130344Yes
287511121112.00.00.0Studies on histones. 7. Preparative methods for histone fractions from calf thymus. E W JohnsBiochem J19645840387Yes
287611121112.025.4525.4Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. M KozakNucleic Acids Res19817301588Yes
287711121112.00.00.0The relation of the trail making test to organic brain damage. R M ReitanJ Consult Psychol195513263471Yes
287822241112.069.7934.9Natural products as sources of new drugs over the last 25 years. David J Newman, Gordon M CraggJ Nat Prod200717309302No
287911111111.024.3424.3An overview of epithelio-mesenchymal transformation. E D HayActa Anat (Basel)19958714286No
288011111111.00.00.0The powerful placebo. H K BeecherJ Am Med Assoc195513271123Yes
288166651110.8231.4138.6The occurrence of sleep-disordered breathing among middle-aged adults. T Young, M Palta, J Dempsey, J Skatrud, S Weber, S BadrN Engl J Med19938464434Yes
288211101110.023.6423.6ALSCRIPT: a tool to format multiple sequence alignments. G J BartonProtein Eng19938433969Yes
288311101110.032.2232.2The effects of stressful life events on depression. R C KesslerAnnu Rev Psychol19979046559No
288444381109.5105.7526.4Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. G L Wang, B H Jiang, E A Rue, G L SemenzaProc Natl Acad Sci U S A19957539918Yes
288522191109.562.3631.2A neurotrophic model for stress-related mood disorders. Ronald S Duman, Lisa M MonteggiaBiol Psychiatry200616631126No
288611091109.035.0435.0Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J E OesterlingJ Urol19911707989No
288711091109.00.00.0Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units. C M VenkatachalamBiopolymers19685685102Yes
288811091109.029.829.8The neurobiology of stress: from serendipity to clinical relevance. B S McEwenBrain Res200011119695No
288922181109.053.6726.8Quorum sensing in bacteria. M B Miller, B L BasslerAnnu Rev Microbiol200111544353No
289011091109.024.9224.9The enzymes, regulation, and genetics of bile acid synthesis. David W RussellAnnu Rev Biochem200312543708No
289111091109.030.5530.6Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Paul WillnerNeuropsychobiology200516037678No
289211091109.030.7530.8Physiology and pathophysiology of purinergic neurotransmission. Geoffrey BurnstockPhysiol Rev200717429044No
289322171108.546.3323.2Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. G A Gonzalez, M R MontminyCell19892573431Yes
289411081108.00.00.0Structure of chromatin. R D KornbergAnnu Rev Biochem1977332067No
289522161108.044.0922.0Homeobox genes and axial patterning. W McGinnis, R KrumlaufCell19921346368No
289611081108.028.7728.8Linkage strategies for genetically complex traits. I. Multilocus models. N RischAm J Hum Genet19902301392Yes
289722151107.549.1824.6Prediction of protein secondary structure at better than 70% accuracy. B Rost, C SanderJ Mol Biol19938345525Yes
289822141107.060.4730.2Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. R A Ignotz, J MassaguéJ Biol Chem19863456347Yes
289911071107.031.1431.1Leishmaniasis. B L HerwaldtLancet199910513726No
290022141107.00.00.0Microdroplet Assay Of Human Serum Cytotoxins. P I Terasaki, J D McclellandNature196414248725Yes
290122141107.047.7723.9The mammalian unfolded protein response. Martin Schröder, Randal J KaufmanAnnu Rev Biochem200515952902No
290211061106.037.7437.7Chemoprevention of cancer. L W WattenbergCancer Res19853880665No
290311061106.032.2932.3A Wilcoxon-type test for trend. J CuzickStat Med19853992076Yes
290411061106.043.3443.3Molecular aspects of ligand binding to serum albumin. U Kragh-HansenPharmacol Rev19817027277No
290522121106.072.1736.1Modeling and comparison of dissolution profiles. P Costa, J M Sousa LoboEur J Pharm Sci200111297896No
290611061106.027.6627.7Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Hiroshi TakayanagiNat Rev Immunol200717380158No
290733161105.3108.9836.3Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. B K Matuszewski, M L Constanzer, C M Chavez-EngAnal Chem200312964746Yes
290822101105.041.2420.6Hedgehog signaling in animal development: paradigms and principles. P W Ingham, A P McMahonGenes Dev200111731473No
290911051105.036.336.3Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Ronald A HitesEnviron Sci Technol200414998004Yes
291022101105.052.926.4Cellular processing of platinum anticancer drugs. Dong Wang, Stephen J LippardNat Rev Drug Discov200515789122No
291122081104.083.3641.7Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. H Esterbauer, K H CheesemanMethods Enzymol19902233308Yes
291222081104.00.00.0Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. R J Britten, D E KohneScience19684874239Yes
291311041104.023.2523.2Apoptosis in neurodegenerative disorders. M P MattsonNat Rev Mol Cell Biol200011253364No
291411041104.027.5927.6Optical microcavities. Kerry J VahalaNature200312917698Yes
291511041104.027.5227.5Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. R Balfour SartorNat Clin Pract Gastroenterol Hepatol200616819502No
291655191103.8190.838.2Posttraumatic stress disorder in the National Comorbidity Survey. R C Kessler, A Sonnega, E Bromet, M Hughes, C B NelsonArch Gen Psychiatry19957492257Yes
291711031103.041.7441.7Omega-3 fatty acids in health and disease and in growth and development. A P SimopoulosAm J Clin Nutr19911908631No
291811031103.028.1128.1Two distinct classes of carbohydrate-recognition domains in animal lectins. K DrickamerJ Biol Chem19883290208No
291911031103.031.0831.1Pharmacology of cannabinoid CB1 and CB2 receptors. R G PertweePharmacol Ther19979336020No
292011031103.025.9826.0The tumor microenvironment and its role in promoting tumor growth. T L WhitesideOncogene200818836471No
292111031103.00.00.0Knee joint changes after meniscectomy. T J FairbankJ Bone Joint Surg Br194818894618Yes
292233081102.70.00.0Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. M Hamberg, J Svensson, B SamuelssonProc Natl Acad Sci U S A19751059088Yes
292322051102.50.00.0Construction of phylogenetic trees. W M Fitch, E MargoliashScience19675334057No
292422051102.571.2735.6Excitatory amino acid transmitters. J C Watkins, R H EvansAnnu Rev Pharmacol Toxicol19816112965No
292522051102.50.00.0Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. A H Coons, M H KaplanJ Exp Med195015395569Yes
292622051102.547.7223.9NF-kappaB: linking inflammation and immunity to cancer development and progression. Michael Karin, Florian R GretenNat Rev Immunol200516175180No
292766141102.3226.2937.7Antioxidant activity applying an improved ABTS radical cation decolorization assay. R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-EvansFree Radic Biol Med199910381194Yes
292811021102.023.1223.1Differentiation and proliferation of hematopoietic stem cells. M OgawaBlood19938499622No
292922041102.055.4627.7C-reactive protein: a critical update. Mark B Pepys, Gideon M HirschfieldJ Clin Invest200312813013No
293011021102.00.00.0The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. J VagueAm J Clin Nutr195613282851Yes
293111021102.043.7843.8The role of senescent cells in ageing. Jan M van DeursenNature201424848057No
293233051101.784.928.3Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. Y Zhang, M Brady, S SmithIEEE Trans Med Imaging200111293691Yes
293311011101.00.00.0Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. K SatohClin Chim Acta1978719890Yes
293411011101.00.00.0A comparison of canal preparations in straight and curved root canals. S W SchneiderOral Surg Oral Med Oral Pathol19715284110Yes
293511011101.00.00.0A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. M G BuonocoreJ Dent Res195513271655Yes
293622011100.550.825.4The canonical Notch signaling pathway: unfolding the activation mechanism. Raphael Kopan, Maria Xenia G IlaganCell200919379690No
293711001100.00.00.0A cytoarchitectonic atlas of the spinal cord in the cat. B RexedJ Comp Neurol195413163236Yes
293833001100.091.0130.3Bacterial biofilms: from the natural environment to infectious diseases. Luanne Hall-Stoodley, J William Costerton, Paul StoodleyNat Rev Microbiol200415040259No
293911001100.033.3233.3Water as an active constituent in cell biology. Philip BallChem Rev200818095715No
294022001100.064.6632.3Integrins in cancer: biological implications and therapeutic opportunities. Jay S Desgrosellier, David A ChereshNat Rev Cancer201020029421No
294110991099.00.00.0The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion. S RosemanChem Phys Lipids19705476326Yes
294210991099.037.4537.5Selective attention and the organization of visual information. J DuncanJ Exp Psychol Gen19846240521Yes
294343961099.0130.2232.6Toxic potential of materials at the nanolevel. Andre Nel, Tian Xia, Lutz Mädler, Ning LiScience200616456071No
294410991099.00.00.0Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins. R D OwenScience194517755278Yes
294510981098.022.4322.4Primary response genes induced by growth factors and tumor promoters. H R HerschmanAnnu Rev Biochem19911883198No
294610981098.021.0121.0Luciferase reporter gene vectors for analysis of promoters and enhancers. S K NordeenBiotechniques19882908509Yes
294710981098.00.00.0Sex-hormone-binding globulin. D C AndersonClin Endocrinol (Oxf)19744134992No
294810981098.024.824.8The molecular biology of leukocyte chemoattractant receptors. P M MurphyAnnu Rev Immunol19948011292No
294943921098.0120.230.1Prevalence and trends in obesity among US adults, 1999-2000. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L JohnsonJAMA200212365955Yes
295010981098.00.00.0Inherited Antithrombin Deficiency Causing Thrombophilia. O EgebergThromb Diath Haemorrh196514347873Yes
295110981098.037.1137.1Socioeconomic status and obesity. Lindsay McLarenEpidemiol Rev200717478442No
295221961098.049.524.8Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. S W Hell, J WichmannOpt Lett199419844443Yes
295321951097.577.2738.6The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. G P Chrousos, P W GoldJAMA19921538563No
295421951097.542.4521.2Dynamic instability of microtubule growth. T Mitchison, M KirschnerNature19846504138Yes
295510971097.034.2634.3Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. M E BoutonPsychol Bull19938346330No
295610971097.021.2421.2Regulation of phosphoinositide-specific phospholipase C. S G RheeAnnu Rev Biochem200111395409No
295710971097.032.1832.2The pollution of the marine environment by plastic debris: a review. José G B DerraikMar Pollut Bull200212405208No
295810971097.029.7229.7Functionalized acenes and heteroacenes for organic electronics. John E AnthonyChem Rev200617165682Yes
295943881097.0126.131.5Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S VasanStat Med200817569110Yes
296010961096.039.4639.5Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. J N WasserheitSex Transm Dis19921595015No
296121921096.059.9830.0Morris water maze: procedures for assessing spatial and related forms of learning and memory. Charles V Vorhees, Michael T WilliamsNat Protoc200617406317Yes
296232881096.0833.74277.9An interactive web-based dashboard to track COVID-19 in real time. Ensheng Dong, Hongru Du, Lauren GardnerLancet Infect Dis202032087114Yes
296310951095.034.6734.7Strategies of antioxidant defense. H SiesEur J Biochem19937688300No
296421891094.566.3733.2Physiological time-series analysis using approximate entropy and sample entropy. J S Richman, J R MoormanAm J Physiol Heart Circ Physiol200010843903Yes
296532821094.072.2124.1A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. M Serrano, G J Hannon, D BeachNature19938259215Yes
296610941094.026.4126.4Evaluating medication effects outside of clinical trials: new-user designs. Wayne A RayAm J Epidemiol200314585769Yes
296710941094.036.4736.5Persister cells. Kim LewisAnnu Rev Microbiol201020528688No
296832801093.376.8725.6Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Axel Nimmerjahn, Frank Kirchhoff, Fritjof HelmchenScience200515831717Yes
296910931093.042.1442.1The role of endothelium in the responses of vascular smooth muscle to drugs. R F FurchgottAnnu Rev Pharmacol Toxicol19846203480No
297010931093.00.00.0Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. P B MedawarBr J Exp Pathol194818865105Yes
297121851092.561.0130.5EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. Stefan Stoll, Arthur SchweigerJ Magn Reson200616188474Yes
297210921092.023.223.2A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. J MilbrandtScience19873672127Yes
297310921092.021.8321.8Cytokine receptor signalling. J N IhleNature19957566171No
297410921092.037.837.8beta-Lactamases in laboratory and clinical resistance. D M LivermoreClin Microbiol Rev19958665470No
297510921092.024.2824.3Assortative mixing in networks. M E J NewmanPhys Rev Lett200212443515Yes
297665481091.3202.8133.8Free radicals and antioxidants in normal physiological functions and human disease. Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua TelserInt J Biochem Cell Biol200716978905No
297710911091.020.4620.5The development of neural stem cells. S TempleNature200111689956No
297810911091.022.1422.1A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. Xuemei ChenScience200412893888Yes
297921821091.00.00.0A revision of the Schoenheimer-Sperry method for cholesterol determination. W M Sperry, M WebbJ Biol Chem195014794694Yes
298021801090.00.00.0Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. A Warshel, M LevittJ Mol Biol1976985660Yes
298121801090.065.0332.5Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. P Brugada, J BrugadaJ Am Coll Cardiol19921309182Yes
298210901090.00.00.0The purine and pyrimidine composition of deoxypentose nucleic acids. G R WyattBiochem J195114838906Yes
298310901090.022.4522.4Inferences, questions and possibilities in Toll-like receptor signalling. Bruce BeutlerNature200415241424No
298410901090.085.2985.3Making sense of implementation theories, models and frameworks. Per NilsenImplement Sci201525895742Yes
298543591089.888.8122.2Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. L Alexopoulou, A C Holt, R Medzhitov, R A FlavellNature200111607032Yes
298610891089.023.0223.0T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. R H SchwartzAnnu Rev Immunol19852415139No
298721781089.068.3134.2A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. A Ennaceur, J DelacourBehav Brain Res19883228475Yes
298810891089.032.2832.3Cholesterol and the cell membrane. P L YeagleBiochim Biophys Acta19853904832No
298910891089.030.4230.4Venous thrombosis: a multicausal disease. F R RosendaalLancet199910209995No
299010891089.00.00.0Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. R M BerneAm J Physiol196313971060Yes
299121771088.559.0229.5Hydrogels for tissue engineering: scaffold design variables and applications. Jeanie L Drury, David J MooneyBiomaterials200312922147No
299221771088.573.2736.6Plasmonics for improved photovoltaic devices. Harry A Atwater, Albert PolmanNat Mater201020168344Yes
299310881088.046.3946.4A spreading-activation theory of retrieval in sentence production. G S DellPsychol Rev19863749399Yes
299410881088.043.7843.8Freezing of living cells: mechanisms and implications. P MazurAm J Physiol19846383068No
299510881088.032.5732.6Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. M J GassonJ Bacteriol19836403500Yes
299621761088.00.00.0Micromethod for the direct determination of serum triglycerides. E Van Handel, D B ZilversmitJ Lab Clin Med195713439279Yes
299710881088.026.4126.4Nonaqueous liquid electrolytes for lithium-based rechargeable batteries. Kang XuChem Rev200415669157Yes
299810881088.031.7931.8Infection in solid-organ transplant recipients. Jay A FishmanN Engl J Med200718094380No
299910871087.00.00.0Corticosteroids and lymphoid cells. H N ClamanN Engl J Med19725043524Yes
300021731086.544.0722.0RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. M B Shapiro, P SenapathyNucleic Acids Res19873658675Yes
300121731086.553.8826.9Cell cycle, CDKs and cancer: a changing paradigm. Marcos Malumbres, Mariano BarbacidNat Rev Cancer200919238148No
300210861086.026.1926.2Molecular drive: a cohesive mode of species evolution. G DoverNature19827110332Yes
300310861086.023.7623.8Fluorescence spectroscopy of single biomolecules. S WeissScience199910073925No
300410861086.028.7428.7Disorders of iron metabolism. N C AndrewsN Engl J Med199910607817No
300510861086.00.00.0Cleavage of the haem-protein link by acid methylethylketone. F W TealeBiochim Biophys Acta195913837237Yes
3006119421085.6347.1231.6The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristoGenome Res201020644199Yes
300721711085.560.9830.5Biology of incretins: GLP-1 and GIP. Laurie L Baggio, Daniel J DruckerGastroenterology200717498508No
300821711085.569.0934.5Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. S Geman, D GemanIEEE Trans Pattern Anal Mach Intell198422499653Yes
300910851085.026.8226.8Plant salt tolerance. J K ZhuTrends Plant Sci200111173290Yes
301010851085.025.4125.4Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. H J DargieLancet200111356434Yes
301110851085.00.00.0Aniline hydrogen phthalate as a spraying reagent for chromatography of sugars. S M PartridgeNature194918140444Yes
301210841084.033.7833.8The somatic marker hypothesis and the possible functions of the prefrontal cortex. A R DamasioPhilos Trans R Soc Lond B Biol Sci19968941953No
301310841084.021.7721.8Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. A S BaldwinJ Clin Invest200111160144No
301410841084.021.5221.5The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. Y YardenEur J Cancer200111597398No
301510841084.040.4540.5AmpC beta-lactamases. George A JacobyClin Microbiol Rev200919136439No
301610831083.032.9332.9A human model of gastric carcinogenesis. P CorreaCancer Res19883288329No
301710831083.025.325.3G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. Jeffery T DavisAngew Chem Int Ed Engl200414755695No
301810831083.037.1837.2How stigma interferes with mental health care. Patrick CorriganAm Psychol200415491256Yes
301910831083.038.338.3The epidemiology of adult obstructive sleep apnea. Naresh M PunjabiProc Am Thorac Soc200818250205No
302043311082.80.00.0Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. L A Papile, J Burstein, R Burstein, H KofflerJ Pediatr1978305471Yes
302121651082.573.6536.8Physiological parameters in laboratory animals and humans. B Davies, T MorrisPharm Res19938378254No
302232471082.395.2931.8trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. Salvador Capella-Gutiérrez, José M Silla-Martínez, Toni GabaldónBioinformatics200919505945Yes
302310821082.034.3134.3The oxidation hypothesis of atherosclerosis. J L WitztumLancet19947916078No
302410821082.028.9729.0Recent advances in neuroblastoma. John M MarisN Engl J Med201020558371No
302532461082.094.0531.3Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Robert D Schreiber, Lloyd J Old, Mark J SmythScience201121436444No
302610821082.035.2535.2Deconvoluting the context-dependent role for autophagy in cancer. Eileen WhiteNat Rev Cancer201222534666No
302721631081.545.7222.9p53: puzzle and paradigm. L J Ko, C PrivesGenes Dev19968654922No
302810811081.027.8527.9Selectins: interpreters of cell-specific carbohydrate information during inflammation. L A LaskyScience19921439808No
302910811081.027.8627.9Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. M J BerridgeBiochem J19836309155Yes
303021621081.053.2226.6Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Josep M Llovet, Jordi BruixHepatology200312540794No
303110811081.00.00.0The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs. M VogtJ Physiol195413152692Yes
303221611080.556.0428.0Statistical tests of neutrality of mutations. Y X Fu, W H LiGenetics19938454210Yes
303321611080.566.033.0Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Taro Kawai, Shizuo AkiraImmunity201121616434No
303410801080.024.6424.6The myofibroblast in wound healing and fibrocontractive diseases. G GabbianiJ Pathol200312845617No
303521601080.049.3124.7Defining the role of mTOR in cancer. David A Guertin, David M SabatiniCancer Cell200717613433No
303610801080.0115.94115.9Hepatocellular Carcinoma. Augusto VillanuevaN Engl J Med201930970190No
303721581079.045.6322.8Sequence logos: a new way to display consensus sequences. T D Schneider, R M StephensNucleic Acids Res19902172928Yes
303810791079.042.4642.5Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. J T DaugirdasJ Am Soc Nephrol19938305648Yes
303910791079.021.4521.4The power and the promise of DNA methylation markers. Peter W LairdNat Rev Cancer200312671664No
304021581079.070.3835.2Chronic hepatitis B: update 2009. Anna S F Lok, Brian J McMahonHepatology200919714720Yes
304153931078.6270.2454.0Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W StittJ Rheumatol19883068365Yes
304221571078.575.5237.8Pharmaceuticals and personal care products in the environment: agents of subtle change? C G Daughton, T A TernesEnviron Health Perspect199910592150No
304310781078.042.042.0A new international staging system for lung cancer. C F MountainChest19863514171No
304421561078.00.00.0Peroxidase-labeled antibody. A new method of conjugation. P K Nakane, A KawaoiJ Histochem Cytochem19744443551Yes
304510781078.038.3438.3Density matrix formulation for quantum renormalization groups. WhitePhys Rev Lett199210046608Yes
304621561078.053.6926.8Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. M E Feder, G E HofmannAnnu Rev Physiol199910099689No
304710781078.025.2525.2Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. Michael J SandersonMol Biol Evol200211752195Yes
304810781078.00.00.0A New Serum Type System In Man--The Lp System. K BergActa Pathol Microbiol Scand196314064818Yes
304921561078.051.7825.9Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Jing Yang, Robert A WeinbergDev Cell200818539112No
305010781078.038.3738.4Thermal properties of graphene and nanostructured carbon materials. Alexander A BalandinNat Mater201121778997Yes
305121561078.0110.1155.13D bioprinting of tissues and organs. Sean V Murphy, Anthony AtalaNat Biotechnol201425093879Yes
305221551077.566.5133.32,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. A Poland, J C KnutsonAnnu Rev Pharmacol Toxicol19826282188No
305321551077.557.9329.0Oxidative stress, caloric restriction, and aging. R S Sohal, R WeindruchScience19968658196No
305421551077.565.5732.8Tumor metastasis: molecular insights and evolving paradigms. Scott Valastyan, Robert A WeinbergCell201122000009No
305510771077.037.7437.7Multiple organ failure. Pathophysiology and potential future therapy. E A DeitchAnn Surg19921503516No
305610771077.031.0231.0Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. T FeiziNature19852579340Yes
305710771077.032.8732.9What is synergy? M C BerenbaumPharmacol Rev19892692037No
305810771077.043.2443.2Geriatric Depression Scale. J A YesavagePsychopharmacol Bull19883249773Yes
305910771077.00.00.0Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities. F FonnumBiochem J19694982085Yes
306010771077.00.00.0A kinetic photometric method for serum gamma-glutamyl transpeptidase. G SzaszClin Chem19695773262Yes
306110771077.025.7525.8Neurons with graded response have collective computational properties like those of two-state neurons. J J HopfieldProc Natl Acad Sci U S A19846587342Yes
306210771077.030.5330.5Persister cells, dormancy and infectious disease. Kim LewisNat Rev Microbiol200717143318No
306310771077.024.1624.2Version 1.2 of the Crystallography and NMR system. Axel T BrungerNat Protoc200718007608Yes
306410771077.027.3827.4Tumour necrosis factor and cancer. Frances BalkwillNat Rev Cancer200919343034No
306521521076.073.9737.0Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. A E Czeizel, I DudásN Engl J Med19921307234Yes
306610761076.034.4934.5Relations between the statistics of natural images and the response properties of cortical cells. D J FieldJ Opt Soc Am A19873430225Yes
306710761076.00.00.0A teacher rating scale for use in drug studies with children. C K ConnersAm J Psychiatry19694900822Yes
306821521076.048.724.4Cell cycle control and cancer. L H Hartwell, M B KastanScience19947997877No
306910761076.034.5134.5Platelet-rich plasma: evidence to support its use. Robert E MarxJ Oral Maxillofac Surg200415085519No
307021521076.042.8121.4Rho GTPases: biochemistry and biology. Aron B Jaffe, Alan HallAnnu Rev Cell Dev Biol200516212495No
307121511075.50.00.0Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques. P Gold, S O FreedmanJ Exp Med196514270243Yes
307210751075.032.5432.5Analyzing the mosaic structure of genes. J M SmithJ Mol Evol19921556748No
307364501075.0142.6523.8Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. D A Melton, P A Krieg, M R Rebagliati, T Maniatis, K Zinn, M R GreenNucleic Acids Res19846091052Yes
307421501075.047.823.9Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. T Hunter, J PinesCell19947954824No
307510751075.019.0419.0Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. M S WoldAnnu Rev Biochem19979242902No
307621501075.050.9225.5Shape-controlled synthesis of gold and silver nanoparticles. Yugang Sun, Younan XiaScience200212481134Yes
307710751075.00.00.0Asymptomatic infections of the urinary tract. E H KassTrans Assoc Am Physicians195613380946Yes
307821491074.549.9625.0Esophageal cancer. Peter C Enzinger, Robert J MayerN Engl J Med200314657432No
307921491074.565.7632.9Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. Xiaobo Chen, Samuel S MaoChem Rev200717590053Yes
308021481074.00.00.0T antigen is bound to a host protein in SV40-transformed cells. D P Lane, L V CrawfordNature1979218111Yes
308110741074.029.8129.8Aging, energy, and oxidative stress in neurodegenerative diseases. M F BealAnn Neurol19957668820No
308210741074.025.6325.6Next-generation DNA sequencing methods. Elaine R MardisAnnu Rev Genomics Hum Genet200818576944No
308321471073.556.6828.3Protein oxidation in aging, disease, and oxidative stress. B S Berlett, E R StadtmanJ Biol Chem19979252331No
308442931073.20.00.0The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. P J Randle, P B Garland, C N Hales, E A NewsholmeLancet196313990765Yes
308542921073.0143.0735.8The cholinergic hypothesis of geriatric memory dysfunction. R T Bartus, R L Dean, B Beer, A S LippaScience19827046051No
308610731073.037.737.7Amino acids: metabolism, functions, and nutrition. Guoyao WuAmino Acids200919301095No
308710721072.027.1227.1The Trk family of neurotrophin receptors. M BarbacidJ Neurobiol19947852993No
308810721072.023.5623.6PHD: predicting one-dimensional protein structure by profile-based neural networks. B RostMethods Enzymol19968743704Yes
308910721072.031.9431.9Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. P VestergaardOsteoporos Int200717068657No
309021421071.068.7134.4Glutamate and the pathophysiology of hypoxic--ischemic brain damage. S M Rothman, J W OlneyAnn Neurol19862421636No
309121421071.083.0341.5Functional interactions between the gut microbiota and host metabolism. Valentina Tremaroli, Fredrik BäckhedNature201222972297No
309210701070.00.00.0Time-dependent processes in memory storage. J L McGaughScience19665917768Yes
309310701070.022.6222.6Liver regeneration: from myth to mechanism. Rebecca TaubNat Rev Mol Cell Biol200415459664No
309410701070.038.8938.9Tumor delivery of macromolecular drugs based on the EPR effect. Vladimir TorchilinAdv Drug Deliv Rev201120304019No
309542791069.8107.1426.8C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. P M Ridker, C H Hennekens, J E Buring, N RifaiN Engl J Med200010733371Yes
309610691069.018.7218.7Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. R RothsteinMethods Enzymol19912005793Yes
309710691069.028.6628.7The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. R A JainBiomaterials200011055295No
309810691069.021.7921.8VEGF and the quest for tumour angiogenesis factors. Napoleone FerraraNat Rev Cancer200212360282No
309910691069.00.00.0Fertilizing capacity of spermatozoa deposited into the fallopian tubes. M C ChangNature195114882325Yes
310010691069.028.1128.1Electrochemiluminescence (ECL). Mark M RichterChem Rev200415186186No
310110691069.046.2246.2What is self-rated health and why does it predict mortality? Towards a unified conceptual model. Marja JylhäSoc Sci Med200919520474Yes
310253431068.6114.6522.9The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. J W Harper, G R Adami, N Wei, K Keyomarsi, S J ElledgeCell19938242751Yes
310321371068.544.4522.2A survey of telomerase activity in human cancer. J W Shay, S BacchettiEur J Cancer19979282118No
310421361068.062.3231.2The acute phase response. H Baumann, J GauldieImmunol Today19947512342No
310510681068.026.1826.2A tension-based theory of morphogenesis and compact wiring in the central nervous system. D C Van EssenNature19979002514Yes
310610681068.019.2319.2Regulatory T cells in autoimmmunity*. E M ShevachAnnu Rev Immunol200010837065No
310710681068.036.5436.5Checklists for improving rigour in qualitative research: a case of the tail wagging the dog? R S BarbourBMJ200111337448No
310821361068.045.6522.8Plant pathogens and integrated defence responses to infection. J L Dangl, J D JonesNature200111459065No
310910681068.025.9626.0The impact of next-generation sequencing technology on genetics. Elaine R MardisTrends Genet200818262675No
311010671067.00.00.0Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. P StastnyN Engl J Med1978147420Yes
311110671067.00.00.0Statistical quality control and routine data processing for radioimmunoassays and immunoradiometric assays. D RodbardClin Chem19744370388No
311221341067.00.00.0Calcium-dependent bacteriophage DNA infection. M Mandel, A HigaJ Mol Biol19704922220Yes
311310671067.039.8439.8Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants. R W BohannonAge Ageing19979143432Yes
311410671067.033.233.2Electrochemical glucose biosensors. Joseph WangChem Rev200818154363No
311521331066.50.00.0Binding of soluble form of fibroblast surface protein, fibronectin, to collagen. E Engvall, E RuoslahtiInt J Cancer1977903179Yes
311631991066.386.7728.9Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. R Schreck, P Rieber, P A BaeuerleEMBO J19912065663Yes
311721321066.0104.0752.0Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. S F Dworkin, L LeRescheJ Craniomandib Disord19921298767No
311810661066.025.725.7Aptamers: an emerging class of molecules that rival antibodies in diagnostics. S D JayasenaClin Chem199910471678No
311910661066.040.1740.2Volumetric modulated arc therapy: IMRT in a single gantry arc. Karl OttoMed Phys200818293586Yes
312063931065.5163.0527.2Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. S Yusuf, P Sleight, J Pogue, J Bosch, R Davies, G DagenaisN Engl J Med200010639539Yes
312121311065.557.1128.6Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Subhra K Biswas, Alberto MantovaniNat Immunol201020856220No
312210651065.00.00.0Functional connections between cells as revealed by dye-coupling with a highly fluorescent naphthalimide tracer. W W StewartCell1978688392Yes
312321301065.051.0125.5Hepatitis C virus infection. G M Lauer, B D WalkerN Engl J Med200111439948No
312421291064.50.00.0The growth of mouse bone marrow cells in vitro. T R Bradley, D MetcalfAust J Exp Biol Med Sci19664164182Yes
312531931064.30.00.0Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. M Jondal, G Holm, H WigzellJ Exp Med19724114496Yes
312610641064.025.1425.1Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. S H KaufmannCancer Res19892790800Yes
312710641064.025.2825.3Selectins and their ligands: current concepts and controversies. G S KansasBlood19968896391No
312810641064.021.521.5Coiled coils: new structures and new functions. A LupasTrends Biochem Sci19968918191No
312910641064.020.1620.2Chronic myeloid leukemia. C L SawyersN Engl J Med199910219069No
313010641064.024.8524.9Current concepts of the pathogenesis of the acute coronary syndromes. P LibbyCirculation200111457759No
313110641064.030.1830.2Thermo- and pH-responsive polymers in drug delivery. Dirk SchmaljohannAdv Drug Deliv Rev200617125884No
313221271063.553.9527.0The protective effects of estrogen on the cardiovascular system. M E Mendelsohn, R H KarasN Engl J Med199910362825No
313321271063.555.1827.6Hydrogels for tissue engineering. K Y Lee, D J MooneyChem Rev200111710233No
313410631063.025.625.6Cells in stress: transcriptional activation of heat shock genes. R I MorimotoScience19938451637No
313531891063.0122.5440.8Hepatocellular carcinoma. Alejandro Forner, Josep M Llovet, Jordi BruixLancet201222353262No
313621251062.50.00.0Chronic catheterization of the spinal subarachnoid space. T L Yaksh, T A RudyPhysiol Behav197614677603Yes
313742501062.5158.3339.6Prevalence and trends in obesity among US adults, 1999-2008. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R CurtinJAMA201020071471Yes
313810621062.022.622.6Protein tyrosine phosphatases: from genes, to function, to disease. Nicholas K TonksNat Rev Mol Cell Biol200617057753No
313921241062.0114.6457.3Parkinson's disease. Lorraine V Kalia, Anthony E LangLancet201525904081No
314021231061.575.7237.9Social conditions as fundamental causes of disease. B G Link, J PhelanJ Health Soc Behav19957560851No
314121231061.545.2922.6Mitogen-activated protein kinase pathways. M J Robinson, M H CobbCurr Opin Cell Biol19979069255No
314221221061.00.00.0The pathogenesis of atherosclerosis (first of two parts). R Ross, J A GlomsetN Engl J Med1976819830No
314321221061.069.2534.6Wine, alcohol, platelets, and the French paradox for coronary heart disease. S Renaud, M de LorgerilLancet19921351198Yes
314410611061.033.3833.4MOPAC: a semiempirical molecular orbital program. J J StewartJ Comput Aided Mol Des19902197373No
314510611061.030.3430.3Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine. E M TanAdv Immunol19826182766No
314610611061.020.2220.2The ubiquitin-proteasome pathway: on protein death and cell life. A CiechanoverEMBO J19989857172No
314721211060.50.00.0Histochemistry of hepatic phosphatases of a physiologic pH; with special reference to the demonstration of bile canaliculi. M Wachstein, E MeiselAm J Clin Pathol195713410831Yes
314810601060.00.00.0Cell lines derived from late embryonic stages of Drosophila melanogaster. I SchneiderJ Embryol Exp Morphol19724625067Yes
314921201060.045.7522.9The Hsp70 and Hsp60 chaperone machines. B Bukau, A L HorwichCell19989476895No
315021201060.048.1824.1Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. N Sreerama, R W WoodyAnal Biochem200011112271Yes
315110601060.023.7323.7Molecular imaging of cancer with positron emission tomography. Sanjiv Sam GambhirNat Rev Cancer200212209157No
315210601060.029.9830.0Disseminating innovations in health care. Donald M BerwickJAMA200312697800Yes
315321201060.00.00.0Cortisone in ulcerative colitis; final report on a therapeutic trial. S C Truelove, L J WittsBr Med J195513260656Yes
315410601060.00.00.0Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. G D WinterNature196214007593Yes
315510601060.021.4521.4Regulation of cadherin-mediated adhesion in morphogenesis. Barry M GumbinerNat Rev Mol Cell Biol200516025097No
315610601060.044.3744.4The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. Eleonore FröhlichInt J Nanomedicine201223144561No
315710601060.046.7246.7The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults. L S RadloffJ Youth Adolesc199124265004Yes
315810601060.065.2165.2Structure, Function, and Evolution of Coronavirus Spike Proteins. Fang LiAnnu Rev Virol201627578435No
315931791059.7104.6434.9Qualitative research in health care. Analysing qualitative data. C Pope, S Ziebland, N MaysBMJ200010625273No
316021191059.554.6227.3Principles of bioactive lipid signalling: lessons from sphingolipids. Yusuf A Hannun, Lina M ObeidNat Rev Mol Cell Biol200818216770No
316110591059.020.5120.5At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. M KozakJ Mol Biol19873681984Yes
316221181059.076.6438.3Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. A I Basbaum, H L FieldsAnnu Rev Neurosci19846143527No
316310591059.027.5127.5Comparative physiology of salt and water stress. R. MunnsPlant Cell Environ200211841667Yes
316410581058.00.00.0Protein denaturation. C. Theoretical models for the mechanism of denaturation. C TanfordAdv Protein Chem19704912353No
316510581058.019.4119.4Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Eric C LaiNat Genet200211896390Yes
316621161058.064.7432.4Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. Aluísio J D Barros, Vânia N HirakataBMC Med Res Methodol200314567763Yes
316710581058.032.732.7Species concepts and species delimitation. Kevin De QueirozSyst Biol200718027281Yes
316821151057.548.6324.3Synaptic activity and the construction of cortical circuits. L C Katz, C J ShatzScience19968895456No
316910571057.00.00.0A colorimetric method for estimating serum triglycerides. M J FletcherClin Chim Acta19685696963Yes
317010571057.035.835.8High density lipoprotein metabolism. S EisenbergJ Lipid Res19846392459No
317110571057.032.0332.0Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. P S ToftsJ Magn Reson Imaging19979039598No
317210571057.023.6323.6ECM and cell surface proteolysis: regulating cellular ecology. Z WerbCell19979390552No
317321141057.00.00.0Use of glucose oxidase, peroxidase, and O-dianisidine in determination of blood and urinary glucose. A S Huggett, D A NixonLancet195713464070Yes
317410571057.020.3820.4Biological robustness. Hiroaki KitanoNat Rev Genet200415520792No
317510561056.00.00.0Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. D L ColemanDiabetologia1978350680No
317610561056.00.00.0The epidemiologic transition. A theory of the epidemiology of population change. A R OmranMilbank Mem Fund Q19715155251Yes
317710561056.00.00.0The ultrastructural basis of capillary permeability studied with peroxidase as a tracer. M J KarnovskyJ Cell Biol19676061717Yes
317810561056.039.1839.2Coronary physiology. E O FeiglPhysiol Rev19836296890No
317910561056.022.1722.2mRNA stability in mammalian cells. J RossMicrobiol Rev19957565413No
318021121056.057.9329.0Chlorophyll fluorescence--a practical guide. K Maxwell, G N JohnsonJ Exp Bot200010938857No
318110561056.00.00.0A production of amino acids under possible primitive earth conditions. S L MillerScience195313056598Yes
318221121056.00.00.0Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. R R Guillard, J H RytherCan J Microbiol196213902807Yes
318352781055.6103.0620.6The protein kinase complement of the human genome. G Manning, D B Whyte, R Martinez, T Hunter, S SudarsanamScience200212471243No
318431661055.376.1525.4Photodynamic therapy for cancer. Dennis E J G J Dolmans, Dai Fukumura, Rakesh K JainNat Rev Cancer200312724736No
318510551055.024.2624.3How neutrophils kill microbes. Anthony W SegalAnnu Rev Immunol200515771570No
318610541054.021.9622.0The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells. D MetcalfNature19892469962No
318710541054.025.8525.9The granulocyte-macrophage colony-stimulating factors. D MetcalfScience19852990035No
318810541054.024.2324.2Toward self-organization and complex matter. Jean-Marie LehnScience200211923524Yes
318910531053.00.00.0Mechanisms of lipid peroxide formation in animal tissues. E D WillsBiochem J19665964963Yes
319010531053.035.9536.0Socioeconomic disadvantage and child development. V C McLoydAm Psychol19989491747No
319110531053.00.00.0The Permeability Of Capillaries In Various Organs As Determined By Use Of The 'Indicator Diffusion' Method. C CroneActa Physiol Scand196314078649Yes
319210531053.038.0938.1Electrocatalyst approaches and challenges for automotive fuel cells. Mark K DebeNature201222678278Yes
319321051052.575.7137.9Origins and evolution of antibiotic resistance. Julian Davies, Dorothy DaviesMicrobiol Mol Biol Rev201020805405No
319410521052.029.8329.8Mitochondrial genetics: a paradigm for aging and degenerative diseases? D C WallaceScience19921533953Yes
319510521052.027.1427.1Axonal growth-associated proteins. J H SkeneAnnu Rev Neurosci19892648946No
319610521052.027.3527.4Two-stage model of memory trace formation: a role for "noisy" brain states. G BuzsákiNeuroscience19892687720No
319710521052.00.00.0Microtubule formation in vitro in solutions containing low calcium concentrations. R C WeisenbergScience19724626639Yes
319810521052.023.4423.4Complement. Second of two parts. M J WalportN Engl J Med200111297706No
319910521052.034.1734.2MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Amy E PasquinelliNat Rev Genet201222411466No
320042071051.8217.5854.4National Institute of Mental Health Diagnostic Interview Schedule. Its history, characteristics, and validity. L N Robins, J E Helzer, J Croughan, K S RatcliffArch Gen Psychiatry19816260053Yes
320110511051.024.0424.0The inducible transcription activator NF-kappa B: regulation by distinct protein subunits. P A BaeuerleBiochim Biophys Acta19912018779No
320221021051.063.6731.8The biochemistry of P-glycoprotein-mediated multidrug resistance. J A Endicott, V LingAnnu Rev Biochem19892570548No
320310511051.030.3530.4Junctional intercellular communication: the cell-to-cell membrane channel. W R LoewensteinPhysiol Rev19816270711No
320410511051.020.720.7Focal adhesion kinase: the first ten years. J Thomas ParsonsJ Cell Sci200312640026No
320510511051.026.526.5Context and behavioral processes in extinction. Mark E BoutonLearn Mem200415466298No
320631531051.089.0629.7Methods in mammalian autophagy research. Noboru Mizushima, Tamotsu Yoshimori, Beth LevineCell201020144757Yes
320721011050.50.00.0A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. J J Sedmak, S E GrossbergAnal Biochem197768686Yes
320810501050.029.7429.7Determination of total protein. G L PetersonMethods Enzymol19836855607Yes
320910501050.029.1429.1T-cell growth factor. K A SmithImmunol Rev19807000676No
321010501050.047.0947.1Coping theory and research: past, present, and future. R S LazarusPsychosom Med19938346332No
321121001050.00.00.0A microcolorimetric method for the determination of inorganic phosphorus. H H Taussky, E ShorrJ Biol Chem195313061491Yes
321241991049.80.00.0T cell growth factor: parameters of production and a quantitative microassay for activity. S Gillis, M M Ferm, W Ou, K A SmithJ Immunol1978307029Yes
321362991049.8183.3930.6Cancer statistics, 2007. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Taylor Murray, Jiaquan Xu, Michael J ThunCA Cancer J Clin200717237035Yes
321410491049.040.7340.7Infection by verocytotoxin-producing Escherichia coli. M A KarmaliClin Microbiol Rev19892644022No
321510491049.026.1326.1The sphingomyelin cycle and the second messenger function of ceramide. Y A HannunJ Biol Chem19948106344No
321610491049.022.9222.9Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. Sean B CarrollCell200818614008Yes
321731461048.7100.8333.6Health benefits of physical activity: the evidence. Darren E R Warburton, Crystal Whitney Nicol, Shannon S D BredinCMAJ200616534088No
321820971048.5107.8653.9The Emerging Hallmarks of Cancer Metabolism. Natalya N Pavlova, Craig B ThompsonCell Metab201626771115No
321910481048.00.00.0Epidemiology of cancer of the colon and rectum. D P BurkittCancer19715165022Yes
322010481048.030.5930.6Pathogenetic mechanisms of septic shock. J E ParrilloN Engl J Med19938479467No
322110481048.038.0938.1Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. M A LempCLAO J19958565190No
322210481048.027.6227.6Neuropathology of Parkinson's disease. L S FornoJ Neuropathol Exp Neurol19968786384No
322310481048.023.7823.8Pedigree disequilibrium tests for multilocus haplotypes. Frank DudbridgeGenet Epidemiol200312916020Yes
322410481048.034.9434.9Understanding diagnostic tests 3: Receiver operating characteristic curves. Anthony K AkobengActa Paediatr200717376185No
322510481048.028.6228.6TNF-mediated inflammatory disease. J R BradleyJ Pathol200818161752No
322620961048.0115.0557.5Making sense of Cronbach's alpha. Mohsen Tavakol, Reg DennickInt J Med Educ201128029643No
322720951047.550.4125.2A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. J N Cohn, G TognoniN Engl J Med200111759645Yes
322820951047.570.8735.4Extended-connectivity fingerprints. David Rogers, Mathew HahnJ Chem Inf Model201020426451Yes
322962841047.3168.6628.1An obesity-associated gut microbiome with increased capacity for energy harvest. Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I GordonNature200617183312Yes
323020941047.041.1920.6Improved retroviral vectors for gene transfer and expression. A D Miller, G J RosmanBiotechniques19892631796Yes
323110471047.056.8356.8A "rationalized" arcsine transform. G A StudebakerJ Speech Hear Res19854046587Yes
323210471047.032.4632.5Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. P J BasserNMR Biomed19958739270No
323310471047.026.9727.0Automatic quantitation of localized in vivo 1H spectra with LCModel. S W ProvencherNMR Biomed200111410943Yes
323410471047.028.8728.9The emotional dog and its rational tail: a social intuitionist approach to moral judgment. J HaidtPsychol Rev200111699120Yes
323510471047.031.1431.1Stronger Brønsted acids. Takahiko AkiyamaChem Rev200717983247Yes
323610461046.024.4624.5Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis. TirionPhys Rev Lett199610063201Yes
323710451045.027.1427.1Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. J P TamProc Natl Acad Sci U S A19883399498Yes
323810451045.00.00.0Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent. D L MorrisScience194817814729Yes
323920901045.051.2325.6Next-generation DNA sequencing. Jay Shendure, Hanlee JiNat Biotechnol200818846087Yes
324073121044.6221.5531.7Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E MarshStroke19937678184Yes
324120881044.077.6138.8Fingerprinting genomes using PCR with arbitrary primers. J Welsh, M McClellandNucleic Acids Res19902259619Yes
324220881044.041.9121.0A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. C S Hoffman, F WinstonGene19873319781Yes
324310441044.022.5522.6Nucleic acid junctions and lattices. N C SeemanJ Theor Biol19826188926Yes
324410441044.026.5626.6Mode of action of membrane active antimicrobial peptides. Yechiel ShaiBiopolymers200212491537No
324510441044.00.00.0The effect of emotion on cue utilization and the organization of behavior. J A EasterbrookPsychol Rev195913658305Yes
324610431043.033.8133.8Peritonectomy procedures. P H SugarbakerAnn Surg19957826158Yes
324731291043.0148.2249.4Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. F Guillemin, C Bombardier, D BeatonJ Clin Epidemiol19938263569No
324810431043.019.4219.4The Pezcoller lecture: cancer cell cycles revisited. C J SherrCancer Res200010919634No
324910431043.030.3730.4A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Ron HardmanEnviron Health Perspect200616451849No
325010431043.051.4251.4Environmentally induced oxidative stress in aquatic animals. Volodymyr I LushchakAquat Toxicol201121074869No
325110421042.00.00.0Carcinoid tumors. An analysis of 2,837 cases. J D GodwinCancer19751157019Yes
325210421042.057.057.0The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. G A IlizarovClin Orthop Relat Res19892910611Yes
325310421042.029.8729.9Transport of molecules in the tumor interstitium: a review. R K JainCancer Res19873555767No
325410421042.00.00.0Cell communication, calcium ion, and cyclic adenosine monophosphate. H RasmussenScience19704318972Yes
325510421042.00.00.0Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. S IrwinPsychopharmacologia19685679627Yes
325610421042.022.8622.9Microsatellites: simple sequences with complex evolution. Hans EllegrenNat Rev Genet200415153996No
325720841042.048.9724.5Blinded by the Light: The Growing Complexity of p53. Karen H Vousden, Carol PrivesCell200919410540No
325810421042.00.00.0A Serological Differentiation Of Human And Other Groups Of Hemolytic Streptococci. R C LancefieldJ Exp Med193319870148Yes
325920841042.073.1436.6LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. Roman A Laskowski, Mark B SwindellsJ Chem Inf Model201121919503Yes
326010421042.040.640.6Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. Rui WangPhysiol Rev201222535897No
326131251041.7161.1853.7Assessing coping strategies: a theoretically based approach. C S Carver, M F Scheier, J K WeintraubJ Pers Soc Psychol19892926629Yes
326220831041.551.8225.9Modes of resistance to anti-angiogenic therapy. Gabriele Bergers, Douglas HanahanNat Rev Cancer200818650835No
326310411041.030.5630.6Animal mitochondrial DNA: structure and evolution. D R WolstenholmeInt Rev Cytol19921452431No
326410411041.00.00.0Lipid peroxidation damage to cell components. A L TappelFed Proc19734352451Yes
326510411041.041.5141.5Amyloid deposits and amyloidosis: the beta-fibrilloses (second of two parts). G G GlennerN Engl J Med19806990257No
326631221040.7112.7937.6Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. P S Walsh, D A Metzger, R HiguchiBiotechniques19911867860Yes
326752031040.6162.332.5Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. Salim Yusuf, Bertram Pitt, Clarence E Davis, William B Hood, Jay N CohnN Engl J Med19912057034Yes
326820811040.544.822.4The immunoglobulin superfamily--domains for cell surface recognition. A F Williams, A N BarclayAnnu Rev Immunol19883289571No
326920811040.551.4525.7Efficient isolation of genes by using antibody probes. R A Young, R W DavisProc Natl Acad Sci U S A19836219389Yes
327020811040.554.227.1Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. M S Brown, J L GoldsteinAnnu Rev Biochem19836311077No
327120811040.591.9546.0Methods for the thematic synthesis of qualitative research in systematic reviews. James Thomas, Angela HardenBMC Med Res Methodol200818616818Yes
327210401040.00.00.0The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture. J CasselAm J Epidemiol1976782233No
327320801040.042.7521.4Tumour-cell invasion and migration: diversity and escape mechanisms. Peter Friedl, Katarina WolfNat Rev Cancer200312724734No
327420791039.561.9431.0Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. J M Reul, E R de KloetEndocrinology19852998738Yes
327510391039.035.0635.1Fever: role of pyrogens and cryogens. M J KlugerPhysiol Rev19911986393No
327610391039.00.00.0Retention of differentiation potentialities during prolonged cultivation of myogenic cells. D YaffeProc Natl Acad Sci U S A19685245982Yes
327710391039.030.4230.4Muscarinic receptors--characterization, coupling and function. M P CaulfieldPharmacol Ther19937504306No
327810391039.025.5225.5Quantification of beta-sheet amyloid fibril structures with thioflavin T. H LeVineMethods Enzymol199910507030Yes
327920781039.069.5534.8Inflammatory mechanisms in obesity. Margaret F Gregor, Gökhan S HotamisligilAnnu Rev Immunol201121219177No
328020771038.553.9327.0Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis. D C Schwartz, C R CantorCell19846373014Yes
328110381038.050.7850.8Analysis of Fickian and non-Fickian drug release from polymers. N A PeppasPharm Acta Helv19854011621Yes
328220761038.00.00.0A simple method for the preparation of 32-P-labelled adenosine triphosphate of high specific activity. I M Glynn, J B ChappellBiochem J19645832284Yes
328341521038.0109.0927.3Real time quantitative PCR. C A Heid, J Stevens, K J Livak, P M WilliamsGenome Res19968908518Yes
328410381038.036.4836.5A review of psychological risk factors in back and neck pain. S J LintonSpine (Phila Pa 1976)200010788861No
328510381038.020.3220.3Progress in human tumour immunology and immunotherapy. S A RosenbergNature200111357146No
328610371037.00.00.0Transformation of yeast by a replicating hybrid plasmid. J D BeggsNature1978357984Yes
328710371037.024.124.1Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system. T IkemuraJ Mol Biol19816175758Yes
328810371037.024.2424.2The columnar organization of the neocortex. V B MountcastleBrain19979153131No
328910371037.023.5123.5Molecular mechanisms of myocardial remodeling. B SwynghedauwPhysiol Rev19999922372No
329010371037.023.9824.0Measuring information transfer SchreiberPhys Rev Lett200010991308Yes
329120721036.072.3136.2Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Christine Vogel, Edward M MarcotteNat Rev Genet201222411467No
329220711035.578.7839.4A psychomotor stimulant theory of addiction. R A Wise, M A BozarthPsychol Rev19873317472No
329320711035.543.2621.6Community structure in social and biological networks. M Girvan, M E J NewmanProc Natl Acad Sci U S A200212060727No
329410351035.027.927.9Human TH1 and TH2 subsets: doubt no more. S RomagnaniImmunol Today19911680337Yes
329510351035.043.4543.5Toward terminological, conceptual, and statistical clarity in the study of mediators and moderators: examples from the child-clinical and pediatric psychology literatures. G N HolmbeckJ Consult Clin Psychol19979256561Yes
329662101035.0168.328.1Prediction of coronary heart disease using risk factor categories. P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B KannelCirculation19989603539Yes
329710351035.023.0523.1Epstein-Barr virus infection. J I CohenN Engl J Med200010944566No
329810351035.025.1725.2P-450 metabolites of arachidonic acid in the control of cardiovascular function. Richard J RomanPhysiol Rev200211773611No
329920701035.00.00.0A modified ninhydrin reagent for the photometric determination of amino acids and related compounds. S Moore, W H SteinJ Biol Chem195413221596Yes
330020701035.055.9128.0Epidemiology of Parkinson's disease. Lonneke M L de Lau, Monique M B BretelerLancet Neurol200616713924No
330182801035.0236.2829.5A method and server for predicting damaging missense mutations. Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R SunyaevNat Methods201020354512Yes
330210351035.029.0129.0Molecular genetics of colorectal cancer. Eric R FearonAnnu Rev Pathol201121090969No
330320691034.555.4327.7Humans integrate visual and haptic information in a statistically optimal fashion. Marc O Ernst, Martin S BanksNature200211807554Yes
330410341034.028.2628.3Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. F P GuengerichChem Res Toxicol200111409933No
330510341034.00.00.0Notes on continuous stochastic phenomena. P A P MoranBiometrika195015420245Yes
330610341034.021.3621.4Telomeres and human disease: ageing, cancer and beyond. Maria A BlascoNat Rev Genet200516136653No
330751691033.8106.8221.4Electrostatics of nanosystems: application to microtubules and the ribosome. N A Baker, D Sept, S Joseph, M J Holst, J A McCammonProc Natl Acad Sci U S A200111517324Yes
330820671033.539.8919.9Wnt signaling: a common theme in animal development. K M Cadigan, R NusseGenes Dev19979407023No
330910331033.00.00.0Avidin. N M GreenAdv Protein Chem1975237414Yes
331010331033.023.6123.6Diffraction methods for biological macromolecules. Interactive computer graphics: FRODO. T A JonesMethods Enzymol19853841179Yes
331110331033.00.00.0Tests for emotionality in rats and mice: a review. J ArcherAnim Behav19734578750No
331210331033.022.0922.1Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. Z YangMol Biol Evol19989580986Yes
331320661033.043.7621.9Genomic control for association studies. B Devlin, K RoederBiometrics199911315092Yes
331410331033.018.2818.3Molecular mechanisms of axon guidance. Barry J DicksonScience200212471249No
331510331033.052.6752.7Mechanisms linking social ties and support to physical and mental health. Peggy A ThoitsJ Health Soc Behav201121673143No
331641291032.285.0621.3Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. E Schreiber, P Matthias, M M Müller, W SchaffnerNucleic Acids Res19892771659Yes
331710321032.00.00.0Surface modulation in cell recognition and cell growth. G M EdelmanScience1976769162No
331820641032.046.3623.2Protein-tyrosine kinases. T Hunter, J A CooperAnnu Rev Biochem19852992362No
331920641032.047.3123.7Obesity and insulin resistance. B B Kahn, J S FlierJ Clin Invest200010953022No
332010321032.00.00.0The stereotaxic method and radiosurgery of the brain. L LeksellActa Chir Scand195114914373Yes
332110321032.024.1924.2Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nicholas C DenkoNat Rev Cancer200819143055No
332210321032.00.00.0Cell deaths in normal vertebrate ontogeny. A GlucksmannBiol Rev Camb Philos Soc195124540363Yes
332382551031.9412.2651.5The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jörg Peplies, Frank Oliver GlöcknerNucleic Acids Res201323193283Yes
332441261031.5154.8838.7Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. K F Schulz, I Chalmers, R J Hayes, D G AltmanJAMA19957823387Yes
332520631031.536.8918.4Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. W Gu, R G RoederCell19979288740Yes
332610311031.00.00.0The interaction of a naphthalene dye with apomyoglobin and apohemoglobin. A fluorescent probe of non-polar binding sites. L StryerJ Mol Biol19655867031Yes
332710311031.019.0219.0Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. W KolchBiochem J200011023813No
332810311031.028.4728.5Epidemiology of women and depression. Ronald C KesslerJ Affect Disord200312646294Yes
332910311031.029.8729.9Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. John W NewcomerCNS Drugs200515998156No
333030911030.30.00.0Therapeutic criteria in rheumatoid arthritis. O Steinbrocker, C H Traeger, R C BattermanJ Am Med Assoc194918150288Yes
333120601030.053.2426.6The regulation and function of c-fos and other immediate early genes in the nervous system. M Sheng, M E GreenbergNeuron19901969743No
333210301030.054.4154.4The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. G A IlizarovClin Orthop Relat Res19892912628Yes
333310301030.023.5723.6New ideas about atrial fibrillation 50 years on. Stanley NattelNature200211805846No
333410301030.031.4931.5Regulation of glutathione synthesis. Shelly C LuMol Aspects Med200918601945No
333520591029.548.7524.4Cellular uptake of the tat protein from human immunodeficiency virus. A D Frankel, C O PaboCell19882849510Yes
333620591029.565.7232.9Health effects of fine particulate air pollution: lines that connect. C Arden Pope, Douglas W DockeryJ Air Waste Manag Assoc200616805397No
333720581029.061.5230.8The capacity of visual working memory for features and conjunctions. S J Luck, E K VogelNature19979384378Yes
333810291029.050.2550.2Modeling Development and Disease with Organoids. Hans CleversCell201627315476No
333930861028.780.4526.8Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). R S Spielman, R E McGinnis, W J EwensAm J Hum Genet19938447318Yes
334010281028.00.00.0Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. J OttAm J Hum Genet19744422075Yes
334120561028.042.4321.2IAP family proteins--suppressors of apoptosis. Q L Deveraux, J C ReedGenes Dev19999990849No
334210281028.021.7721.8Osmotic stress signaling and osmoadaptation in yeasts. Stefan HohmannMicrobiol Mol Biol Rev200212040128No
334310281028.022.1122.1Fibrotic disease and the T(H)1/T(H)2 paradigm. Thomas A WynnNat Rev Immunol200415286725No
334410271027.028.8528.9Synchronization of cortical activity and its putative role in information processing and learning. W SingerAnnu Rev Physiol19938466179No
334510271027.029.7829.8Limbic-cortical dysregulation: a proposed model of depression. H S MaybergJ Neuropsychiatry Clin Neurosci19979276848No
334610271027.025.225.2Anatomy and regulation of the central melanocortin system. Roger D ConeNat Neurosci200515856065No
334720531026.540.8920.4The druggable genome. Andrew L Hopkins, Colin R GroomNat Rev Drug Discov200212209152No
334830791026.380.026.7Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions. M Piotto, V Saudek, V SklenárJ Biomol NMR19921490109Yes
334910261026.024.824.8A likelihood approach to estimating phylogeny from discrete morphological character data. P O LewisSyst Biol200112116640Yes
335041041026.0113.0728.3Universal sample preparation method for proteome analysis. Jacek R Wiśniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias MannNat Methods200919377485Yes
335110261026.021.0921.1ChIP-seq: advantages and challenges of a maturing technology. Peter J ParkNat Rev Genet200919736561No
335210261026.00.00.0Connections of the cerebral cortex; the albino rat; topography of the cortical areas. W J S KriegJ Comp Neurol194620982805Yes
335330761025.30.00.0Depression: a new animal model sensitive to antidepressant treatments. R D Porsolt, M Le Pichon, M JalfreNature1977559941Yes
335410251025.034.1234.1Agents that increase the permeability of the outer membrane. M VaaraMicrobiol Rev19921406489No
335510251025.053.1153.1The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. J A KoufmanLaryngoscope19911895864No
335610251025.00.00.0The role of calcium in the release of neurotransmitter substances and hormones. R P RubinPharmacol Rev19704322219No
335710251025.00.00.0The influence of immunologically committed lymphoid cells on macrophage activity in vivo. G B MackanessJ Exp Med19694976110Yes
335810251025.022.8422.8Phenotypic plasticity and the epigenetics of human disease. Andrew P FeinbergNature200717522677No
335910251025.022.9623.0Membrane recognition by phospholipid-binding domains. Mark A LemmonNat Rev Mol Cell Biol200818216767No
336010251025.022.5222.5Up on the tightrope: natural killer cell activation and inhibition. Lewis L LanierNat Immunol200818425106No
336110241024.00.00.0Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system. U UngerstedtActa Physiol Scand Suppl19714332694Yes
336220481024.049.2524.6Regulation of wound healing by growth factors and cytokines. Sabine Werner, Richard GrosePhysiol Rev200312843410No
336310241024.048.948.9Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. Konrad M AndrassyKidney Int201323989362Yes
336420471023.580.8340.4Cronbach's alpha. J M Bland, D G AltmanBMJ19979055718Yes
336510231023.049.3549.4Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder. M RutterBr J Psychiatry19853830321Yes
336610231023.028.4428.4Presynaptic nicotinic ACh receptors. S WonnacottTrends Neurosci19979023878No
336720451022.578.2339.1Visual search and stimulus similarity. J Duncan, G W HumphreysPsychol Rev19892756067Yes
336810221022.00.00.0The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle. M JouvetErgeb Physiol19724403272Yes
336910221022.024.024.0Natural history of chronic hepatitis C. Leonard B SeeffHepatology200212407575No
337010221022.00.00.0Regional blood flow by fractional distribution of indicators. L A SapirsteinAm J Physiol195813521003Yes
337120431021.551.2325.6ZINC--a free database of commercially available compounds for virtual screening. John J Irwin, Brian K ShoichetJ Chem Inf Model200515667143Yes
337230641021.384.8928.3A nonparametric method for automatic correction of intensity nonuniformity in MRI data. J G Sled, A P Zijdenbos, A C EvansIEEE Trans Med Imaging19989617910Yes
337320421021.085.642.8Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. L A Clark, D WatsonJ Abnorm Psychol19911918611No
337410211021.029.3429.3Hepatitis B virus. The major etiology of hepatocellular carcinoma. R P BeasleyCancer19882834034No
337510211021.028.4628.5Akaike's information criterion in generalized estimating equations. W PanBiometrics200111252586Yes
337610211021.00.00.0Motivation reconsidered: the concept of competence. R W WhitePsychol Rev195913844397Yes
337710211021.021.0121.0mTOR and cancer: insights into a complex relationship. David M SabatiniNat Rev Cancer200616915295No
337810201020.032.6132.6Selective modification of glutathione metabolism. A MeisterScience19836836290Yes
337920401020.092.5846.3Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. J B Mulliken, J GlowackiPlast Reconstr Surg19827063565Yes
338010201020.029.4129.4Riddle of biofilm resistance. K LewisAntimicrob Agents Chemother200111257008No
338140791019.8137.0634.3Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. W Vale, J Spiess, C Rivier, J RivierScience19816267699Yes
338240791019.8106.9426.7A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. I Vermes, C Haanen, H Steffens-Nakken, C ReutelingspergerJ Immunol Methods19957622868Yes
338320391019.577.238.6The Modified Mini-Mental State (3MS) examination. E L Teng, H C ChuiJ Clin Psychiatry19873611032Yes
338410191019.035.1435.1Lipid peroxidation and antioxidants as biomarkers of tissue damage. J M GutteridgeClin Chem19957497639No
338581521019.0324.0340.5Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. R C Kessler, K A McGonagle, S Zhao, C B Nelson, M Hughes, S Eshleman, H U Wittchen, K S KendlerArch Gen Psychiatry19948279933Yes
338610191019.028.3628.4Prostaglandin synthase 2. H R HerschmanBiochim Biophys Acta19968555245No
338720371018.5131.7265.9MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Rajesha Rupaimoole, Frank J SlackNat Rev Drug Discov201728209991No
338830551018.3173.9758.0Fast and sensitive protein alignment using DIAMOND. Benjamin Buchfink, Chao Xie, Daniel H HusonNat Methods201525402007Yes
338930541018.061.6220.5Genetic instabilities in human cancers. C Lengauer, K W Kinzler, B VogelsteinNature19989872311No
339010181018.019.7119.7DNA methylation in cancer: too much, but also too little. Melanie EhrlichOncogene200212154403No
339130521017.3100.6233.5SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building. Manolo Gouy, Stéphane Guindon, Olivier GascuelMol Biol Evol201019854763Yes
339210171017.021.2121.2Resolution of phase ambiguity in macromolecular crystallography. B C WangMethods Enzymol19854079800Yes
339310171017.00.00.0Simplified Myeloperoxidase Stain Using Benzidine Dihydrochloride. L S KaplowBlood196514332483Yes
339420341017.046.6723.3Regeneration beyond the glial scar. Jerry Silver, Jared H MillerNat Rev Neurosci200414735117No
339510171017.024.324.3Personal genomes: The case of the missing heritability. Brendan MaherNature200818987709No
339610161016.049.9550.0Self-discrepancy: a theory relating self and affect. E T HigginsPsychol Rev19873615707Yes
339710161016.00.00.0Presidental address. Neuropathological aspects of brain edema. I KlatzoJ Neuropathol Exp Neurol19675336776No
339810161016.036.9737.0Methods for dealing with reaction time outliers. R RatcliffPsychol Bull19938272468Yes
339910161016.021.9922.0Oxidant signals and oxidative stress. Toren FinkelCurr Opin Cell Biol200312648682No
340010161016.00.00.0Fluorescent antibody methods. A H CoonsGen Cytochem Methods195813574437Yes
340140631015.8104.6226.2Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod MenonProc Natl Acad Sci U S A200312506194Yes
340220311015.577.3538.7Understanding face recognition. V Bruce, A YoungBr J Psychol19863756376Yes
340330461015.361.5720.5Exosomes: composition, biogenesis and function. Clotilde Théry, Laurence Zitvogel, Sebastian AmigorenaNat Rev Immunol200212154376No
340410151015.022.1822.2Potential metal-binding domains in nucleic acid binding proteins. J M BergScience19862421409Yes
340510151015.034.7734.8Why we need observational studies to evaluate the effectiveness of health care. N BlackBMJ19968634569Yes
340630451015.065.4821.8TGF-beta signalling from cell membrane to nucleus through SMAD proteins. C H Heldin, K Miyazono, P ten DijkeNature19979393997No
340710151015.025.325.3Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures. Frank WürthnerChem Commun (Camb)200415263926Yes
340820281014.00.00.0Analysis of probability as an aid in the clinical diagnosis of coronary-artery disease. G A Diamond, J S ForresterN Engl J Med1979440357Yes
340910141014.031.7331.7Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion. E FalkCirculation19853971539Yes
341010141014.029.1429.1The stress response to trauma and surgery. J P DesboroughBr J Anaesth200010927999No
341110141014.025.525.5Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Bei-Fan ZhouBiomed Environ Sci200212046553Yes
341210141014.025.6925.7Solid-state nanopores. Cees DekkerNat Nanotechnol200718654264No
341310141014.0389.6389.6COVID-19 and mental health: A review of the existing literature. Ravi Philip RajkumarAsian J Psychiatr202032302935Yes
341420261013.00.00.0Role of cell shape in growth control. J Folkman, A MosconaNature1978661946Yes
341510131013.017.5917.6Functional inactivation of genes by dominant negative mutations. I HerskowitzNature19872442619No
341620261013.063.2231.6Multiple significance tests: the Bonferroni method. J M Bland, D G AltmanBMJ19957833759Yes
341710131013.031.1531.1Spatially heterogeneous dynamics in supercooled liquids. M D EdigerAnnu Rev Phys Chem200011031277Yes
341810131013.024.1524.1The prefrontal cortex--an update: time is of the essence. J M FusterNeuron200111394996No
341910131013.026.8426.8The potential environmental impact of engineered nanomaterials. Vicki L ColvinNat Biotechnol200314520401Yes
342020261013.059.1429.6A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions. Yan Zhao, Donald G TruhlarJ Chem Phys200617129083Yes
342120261013.090.8845.4Liposomal drug delivery systems: from concept to clinical applications. Theresa M Allen, Pieter R CullisAdv Drug Deliv Rev201323036225No
342210121012.035.5135.5Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance. M D MajewskaProg Neurobiol19921349441No
342320241012.054.7127.4Compilation and analysis of Escherichia coli promoter DNA sequences. D K Hawley, W R McClureNucleic Acids Res19836344016No
342430361012.0104.734.9The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting. C Kirschbaum, K M Pirke, D H HellhammerNeuropsychobiology19938255414Yes
342510121012.032.7832.8Sensorimotor integration in human postural control. R J PeterkaJ Neurophysiol200212205132Yes
342640471011.8121.7630.4Measurement of the elastic properties and intrinsic strength of monolayer graphene. Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James HoneScience200818635798Yes
342730351011.762.9321.0The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. W H Landschulz, P F Johnson, S L McKnightScience19883289117Yes
342810111011.029.0229.0Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease. W J WelchPhysiol Rev19921438579No
342920221011.041.6620.8Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. P E Wright, H J DysonJ Mol Biol199910550212No
343020211010.542.0521.0In search of the 'missing self': MHC molecules and NK cell recognition. H G Ljunggren, K KärreImmunol Today19902201309No
343120211010.553.8726.9An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Gary Aston-Jones, Jonathan D CohenAnnu Rev Neurosci200516022602No
343210101010.053.7953.8Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem. P D HenryAm J Cardiol19806255787No
343310101010.029.5629.6Nitric oxide synthase structure and mechanism. M A MarlettaJ Biol Chem19937685338No
343430301010.087.5529.2Spirometric reference values from a sample of the general U.S. population. J L Hankinson, J R Odencrantz, K B FedanAm J Respir Crit Care Med19999872837Yes
343520201010.044.4522.2Protein aggregation and neurodegenerative disease. Christopher A Ross, Michelle A PoirierNat Med200415272267No
343610101010.00.00.0Histological and histochemical uses of periodic acid. J F A McMANUSStain Technol194818867618Yes
343730291009.70.00.0Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose. P L Ey, S J Prowse, C R JenkinImmunochemistry197830693Yes
343830291009.780.2226.7Use and abuse of HOMA modeling. Tara M Wallace, Jonathan C Levy, David R MatthewsDiabetes Care200415161807No
343920191009.536.4418.2A synthetic oscillatory network of transcriptional regulators. M B Elowitz, S LeiblerNature200010659856Yes
344020191009.542.7921.4Of mice and not men: differences between mouse and human immunology. Javier Mestas, Christopher C W HughesJ Immunol200414978070No
344120191009.546.6323.3Deep tissue two-photon microscopy. Fritjof Helmchen, Winfried DenkNat Methods200516299478No
344210091009.038.6938.7The ovariectomized rat model of postmenopausal bone loss. D N KaluBone Miner19911773131No
344310091009.00.00.0Vagal sensory receptors and their reflex effects. A S PaintalPhysiol Rev19734568412No
344410091009.026.7126.7Glutathione and its role in cellular functions. H SiesFree Radic Biol Med199910569624No
344510091009.033.4433.4Predictors of postpartum depression: an update. C T BeckNurs Res200111570712Yes
344620171008.560.3230.2Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. C N Hales, D J BarkerDiabetologia19921644236No
344760511008.5190.7831.8Prevalence of overweight and obesity in the United States, 1999-2004. Cynthia L Ogden, Margaret D Carroll, Lester R Curtin, Margaret A McDowell, Carolyn J Tabak, Katherine M FlegalJAMA200616595758Yes
344820161008.00.00.0Fine structural localization of a blood-brain barrier to exogenous peroxidase. T S Reese, M J KarnovskyJ Cell Biol19676033532Yes
344930231007.7132.2644.1Measurement of health status. Ascertaining the minimal clinically important difference. R Jaeschke, J Singer, G H GuyattControl Clin Trials19892691207Yes
345030231007.774.3124.8Nitric oxide and macrophage function. J MacMicking, Q W Xie, C NathanAnnu Rev Immunol19979143691No
345110071007.029.9429.9Cytochrome oxidase: an endogenous metabolic marker for neuronal activity. M T Wong-RileyTrends Neurosci19892469224No
345210071007.038.138.1Spin trapping: ESR parameters of spin adducts. G R BuettnerFree Radic Biol Med19872826304No
345310071007.00.00.0Isolation of an organ specific protein antigen from cell-surface membrane of rat liver. D M NevilleBiochim Biophys Acta19684967807Yes
345410071007.028.2628.3The role of protein phosphorylation in neural and hormonal control of cellular activity. P CohenNature19826280056No
345530211007.088.7829.6A sensitive and reliable locomotor rating scale for open field testing in rats. D M Basso, M S Beattie, J C BresnahanJ Neurotrauma19957783230Yes
345660391006.5159.5626.6Ghrelin is a growth-hormone-releasing acylated peptide from stomach. M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K KangawaNature199910604470Yes
345730191006.387.2229.1Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Robert G Hart, Lesly A Pearce, Maria I AguilarAnn Intern Med200717577005Yes
345820121006.052.826.4Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. M Tsujii, R N DuBoisCell19958521479Yes
345920121006.040.420.2Cellular functions regulated by Src family kinases. S M Thomas, J S BruggeAnnu Rev Cell Dev Biol19979442882No
346010061006.029.7729.8The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. S Nolen-HoeksemaJ Abnorm Psychol200011016119Yes
346140241006.0118.3729.6Biological identifications through DNA barcodes. Paul D N Hebert, Alina Cywinska, Shelley L Ball, Jeremy R deWaardProc Biol Sci200312614582Yes
346220121006.045.1622.6Roles of CHOP/GADD153 in endoplasmic reticulum stress. S Oyadomari, M MoriCell Death Differ200414685163No
346310061006.024.9224.9Nitric oxide, oxidants, and protein tyrosine nitration. Rafael RadiProc Natl Acad Sci U S A200415020765Yes
346410061006.059.9359.9PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors. Anthony L SpekActa Crystallogr C Struct Chem201525567569Yes
346510061006.065.1265.1Hydrogel: Preparation, characterization, and applications: A review. Enas M AhmedJ Adv Res201525750745No
346620111005.569.0434.5Efficacy of the Theory of Planned Behaviour: a meta-analytic review. C J Armitage, M ConnerBr J Soc Psychol200111795063Yes
346720101005.081.9841.0A simple method to assess exercise behavior in the community. G Godin, R J ShephardCan J Appl Sport Sci19854053261Yes
346810051005.025.8525.9Molten globule and protein folding. O B PtitsynAdv Protein Chem19958561052No
346910051005.019.7919.8Initiation of translation in prokaryotes and eukaryotes. M KozakGene199910395892No
347010051005.024.9424.9Differential projections of the infralimbic and prelimbic cortex in the rat. Robert P VertesSynapse200414579424Yes
347110051005.00.00.0The Stability of Broken Ends of Chromosomes in Zea Mays. B McClintockGenetics194117247004Yes
347220091004.563.5331.8Heterogeneous photocatalyst materials for water splitting. Akihiko Kudo, Yugo MisekiChem Soc Rev200919088977Yes
347340171004.20.00.0Coated charcoal immunoassay of insulin. V Herbert, K S Lau, C W Gottlieb, S J BleicherJ Clin Endocrinol Metab19655320561Yes
347410041004.00.00.0Evolution of ageing. T B KirkwoodNature1977593350Yes
347520081004.079.6139.8Glutathione reductase. I Carlberg, B MannervikMethods Enzymol19853003504Yes
347610041004.031.6831.7Topography of cognition: parallel distributed networks in primate association cortex. P S Goldman-RakicAnnu Rev Neurosci19883284439No
347710041004.041.1241.1Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. R J CousinsPhysiol Rev19853885271No
347810041004.029.029.0Advanced protein glycosylation in diabetes and aging. M BrownleeAnnu Rev Med19957598459No
347910041004.032.1432.1Food reward: brain substrates of wanting and liking. K C BerridgeNeurosci Biobehav Rev19968622814No
348010041004.018.6918.7Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. R A FryeBiochem Biophys Res Commun200010873683Yes
348110041004.022.822.8Serine protease mechanism and specificity. Lizbeth HedstromChem Rev200212475199No
348210041004.023.0223.0Sustainable hydrogen production. John A TurnerScience200415310892Yes
348310041004.034.8134.8Clinical practice. Endometriosis. Linda C GiudiceN Engl J Med201020573927No
348430111003.793.8131.3Regulation of cancer cell metabolism. Rob A Cairns, Isaac S Harris, Tak W MakNat Rev Cancer201121258394No
348520071003.50.00.0A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. G C Liggins, R N HowiePediatrics19724561295Yes
348620071003.555.8627.9Fitness effects on the cognitive function of older adults: a meta-analytic study. Stanley Colcombe, Arthur F KramerPsychol Sci200312661673Yes
348710031003.034.134.1A practical computer-based approach to the analysis of radioligand binding experiments. G A McPhersonComput Programs Biomed19836319079Yes
348810031003.038.0338.0Cellular mechanisms of muscle fatigue. R H FittsPhysiol Rev19948295935No
348910031003.026.1126.1Skeletal complications of malignancy. R E ColemanCancer19979362426No
349010031003.025.5725.6Anti-inflammatory actions of glucocorticoids: molecular mechanisms. P J BarnesClin Sci (Lond)19989854452No
349140121003.0100.2525.1The epidemiology of sepsis in the United States from 1979 through 2000. Greg S Martin, David M Mannino, Stephanie Eaton, Marc MossN Engl J Med200312700374Yes
349220051002.557.9729.0BODIPY dyes and their derivatives: syntheses and spectroscopic properties. Aurore Loudet, Kevin BurgessChem Rev200717924696Yes
349330071002.3111.8437.3Neighborhoods and violent crime: a multilevel study of collective efficacy. R J Sampson, S W Raudenbush, F EarlsScience19979252316Yes
349410021002.00.00.0Serine proteases: structure and mechanism of catalysis. J KrautAnnu Rev Biochem1977332063No
349520031001.50.00.0Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. S Ohkuma, B PooleProc Natl Acad Sci U S A197828524Yes
349620031001.50.00.0The period of susceptibility to the physiological effects of unilateral eye closure in kittens. D H Hubel, T N WieselJ Physiol19705498493Yes
349760081001.3143.2523.9Principal components analysis corrects for stratification in genome-wide association studies. Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David ReichNat Genet200616862161Yes
349810011001.029.7229.7Classes of calcium channels in vertebrate cells. B P BeanAnnu Rev Physiol19892540697No
349920021001.072.5936.3A simple index of Crohn's-disease activity. R F Harvey, J M BradshawLancet19806102236Yes
350010011001.028.5128.5Intermediate filaments: a chemically heterogeneous, developmentally regulated class of proteins. E LazaridesAnnu Rev Biochem19826180679No
350110011001.00.00.0Pelvic Scoring For Elective Induction. E H BishopObstet Gynecol196414199536Yes
350210011001.024.9625.0Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. William C AirdCirc Res200717272818No
350320011000.50.00.0Comparative aspects of the brain growth spurt. J Dobbing, J SandsEarly Hum Dev1979118862Yes
350420011000.559.5729.8Glycoprotein hormones: structure and function. J G Pierce, T F ParsonsAnnu Rev Biochem19816267989No
350520011000.547.0123.5microRNA functions. Natascha Bushati, Stephen M CohenAnnu Rev Cell Dev Biol200717506695No
350620001000.00.00.0Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. M J Mulvany, W HalpernCirc Res1977862138Yes
350710001000.025.2725.3The leptin receptor. L A TartagliaJ Biol Chem19979102398No
350810001000.024.0524.1Atherosclerosis is an inflammatory disease. R RossAm Heart J199910539839No
350910001000.028.7528.8Ion suppression in mass spectrometry. Thomas M AnnesleyClin Chem200312816898No
351010001000.00.00.0Neural basis of the spontaneous optokinetic response produced by visual inversion. R W SperryJ Comp Physiol Psychol195014794830Yes

              Download as CSV


Copyright © 2020-2022 Solid Scientometrics Sp. z o.o.                                         Terms of Service                                                             Designed by Lukasz P. Kozlowski

All information that Unicorn Papers provides is based on PubMed data that are within the public domain. We acknowledge the NCBI, NLM, ORCID and iCite teams.