No. | Citations | ECcit | RCR | ECRCR | Title | Authors | Journal | Year | PMID | Article(?) |
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1 | 221804 | 221804.0 | 0.0 | 0.0 | Cleavage of structural proteins during the assembly of the head of bacteriophage T4. | U K Laemmli | Nature | 1970 | 5432063 | Yes |
2 | 168697 | 168697.0 | 0.0 | 0.0 | A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. | M M Bradford | Anal Biochem | 1976 | 942051 | Yes |
3 | 285206 | 71301.5 | 0.0 | 0.0 | Protein measurement with the Folin phenol reagent. | O H Lowry, N J Rosebrough, A L Farr, R J Randall | J Biol Chem | 1951 | 14907713 | Yes |
4 | 98204 | 49102.0 | 2526.06 | 1263.0 | Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. | K J Livak, T D Schmittgen | Methods | 2001 | 11846609 | Yes |
5 | 43141 | 43141.0 | 1446.68 | 1446.7 | A short history of SHELX. | George M Sheldrick | Acta Crystallogr A | 2008 | 18156677 | Yes |
6 | 33851 | 33851.0 | 1100.18 | 1100.2 | Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. | T Mosmann | J Immunol Methods | 1983 | 6606682 | Yes |
7 | 65097 | 32548.5 | 1973.94 | 987.0 | Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. | P Chomczynski, N Sacchi | Anal Biochem | 1987 | 2440339 | Yes |
8 | 30180 | 30180.0 | 0.0 | 0.0 | Detection of specific sequences among DNA fragments separated by gel electrophoresis. | E M Southern | J Mol Biol | 1975 | 1195397 | Yes |
9 | 25561 | 25561.0 | 0.0 | 0.0 | The assessment and analysis of handedness: the Edinburgh inventory. | R C Oldfield | Neuropsychologia | 1971 | 5146491 | Yes |
10 | 25148 | 25148.0 | 580.77 | 580.8 | MicroRNAs: genomics, biogenesis, mechanism, and function. | David P Bartel | Cell | 2004 | 14744438 | No |
11 | 23762 | 23762.0 | 0.0 | 0.0 | A rating scale for depression. | M Hamilton | J Neurol Neurosurg Psychiatry | 1960 | 14399272 | Yes |
12 | 22565 | 22565.0 | 708.14 | 708.1 | Confidence Limits On Phylogenies: An Approach Using The Bootstrap. | Joseph Felsenstein | Evolution | 1985 | 28561359 | Yes |
13 | 21958 | 21958.0 | 544.05 | 544.0 | MUSCLE: multiple sequence alignment with high accuracy and high throughput. | Robert C Edgar | Nucleic Acids Res | 2004 | 15034147 | Yes |
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15 | 21687 | 21687.0 | 515.88 | 515.9 | A new mathematical model for relative quantification in real-time RT-PCR. | M W Pfaffl | Nucleic Acids Res | 2001 | 11328886 | Yes |
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17 | 19968 | 19968.0 | 0.0 | 0.0 | The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. | E S Reynolds | J Cell Biol | 1963 | 13986422 | Yes |
18 | 36993 | 18496.5 | 1148.54 | 574.3 | The neighbor-joining method: a new method for reconstructing phylogenetic trees. | N Saitou, M Nei | Mol Biol Evol | 1987 | 3447015 | Yes |
19 | 18467 | 18467.0 | 656.0 | 656.0 | Density-functional exchange-energy approximation with correct asymptotic behavior. | Becke | Phys Rev A Gen Phys | 1988 | 9900728 | Yes |
20 | 18223 | 18223.0 | 0.0 | 0.0 | Tissue sulfhydryl groups. | G L Ellman | Arch Biochem Biophys | 1959 | 13650640 | Yes |
21 | 53169 | 17723.0 | 0.0 | 0.0 | Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. | H Towbin, T Staehelin, J Gordon | Proc Natl Acad Sci U S A | 1979 | 388439 | Yes |
22 | 16796 | 16796.0 | 0.0 | 0.0 | Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. | B J Davis | Ann N Y Acad Sci | 1964 | 14240539 | Yes |
23 | 33506 | 16753.0 | 1619.66 | 809.8 | Statistical methods for assessing agreement between two methods of clinical measurement. | J M Bland, D G Altman | Lancet | 1986 | 2868172 | Yes |
24 | 33309 | 16654.5 | 1173.6 | 586.8 | Hallmarks of cancer: the next generation. | Douglas Hanahan, Robert A Weinberg | Cell | 2011 | 21376230 | No |
25 | 16312 | 16312.0 | 0.0 | 0.0 | High resolution two-dimensional electrophoresis of proteins. | P H O'Farrell | J Biol Chem | 1975 | 236308 | Yes |
26 | 16160 | 16160.0 | 420.18 | 420.2 | Atherosclerosis--an inflammatory disease. | R Ross | N Engl J Med | 1999 | 9887164 | No |
27 | 15898 | 15898.0 | 0.0 | 0.0 | A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. | K Burton | Biochem J | 1956 | 13293190 | Yes |
28 | 15506 | 15506.0 | 579.57 | 579.6 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. | M Kimura | J Mol Evol | 1980 | 7463489 | Yes |
29 | 30752 | 15376.0 | 0.0 | 0.0 | A rapid method of total lipid extraction and purification. | E G Bligh, W J Dyer | Can J Biochem Physiol | 1959 | 13671378 | Yes |
30 | 29551 | 14775.5 | 0.0 | 0.0 | The measurement of observer agreement for categorical data. | J R Landis, G G Koch | Biometrics | 1977 | 843571 | Yes |
31 | 43509 | 14503.0 | 1257.01 | 419.0 | CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. | J D Thompson, D G Higgins, T J Gibson | Nucleic Acids Res | 1994 | 7984417 | Yes |
32 | 41004 | 13668.0 | 0.0 | 0.0 | A simple method for the isolation and purification of total lipides from animal tissues. | J Folch, M Lees, G H Sloane Stanley | J Biol Chem | 1957 | 13428781 | Yes |
33 | 13624 | 13624.0 | 372.68 | 372.7 | MicroRNAs: target recognition and regulatory functions. | David P Bartel | Cell | 2009 | 19167326 | No |
34 | 13314 | 13314.0 | 393.72 | 393.7 | Projector augmented-wave method. | Blöchl | Phys Rev B Condens Matter | 1994 | 9976227 | Yes |
35 | 13100 | 13100.0 | 553.48 | 553.5 | A power primer. | J Cohen | Psychol Bull | 1992 | 19565683 | Yes |
36 | 25963 | 12981.5 | 999.01 | 499.5 | Meta-analysis in clinical trials. | R DerSimonian, N Laird | Control Clin Trials | 1986 | 3802833 | Yes |
37 | 25388 | 12694.0 | 1054.42 | 527.2 | The hospital anxiety and depression scale. | A S Zigmond, R P Snaith | Acta Psychiatr Scand | 1983 | 6880820 | Yes |
38 | 12660 | 12660.0 | 0.0 | 0.0 | Phosphorus assay in column chromatography. | G R Bartlett | J Biol Chem | 1959 | 13641241 | Yes |
39 | 12227 | 12227.0 | 485.44 | 485.4 | Catalase in vitro. | H Aebi | Methods Enzymol | 1984 | 6727660 | Yes |
40 | 12079 | 12079.0 | 624.1 | 624.1 | RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. | Alexandros Stamatakis | Bioinformatics | 2014 | 24451623 | Yes |
41 | 34341 | 11447.0 | 1065.59 | 355.2 | Generalized Gradient Approximation Made Simple. | Perdew, Burke, Ernzerhof | Phys Rev Lett | 1996 | 10062328 | Yes |
42 | 56054 | 11210.8 | 1620.8 | 324.2 | Basic local alignment search tool. | S F Altschul, W Gish, W Miller, E W Myers, D J Lipman | J Mol Biol | 1990 | 2231712 | Yes |
43 | 22189 | 11094.5 | 937.56 | 468.8 | The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. | J E Ware, C D Sherbourne | Med Care | 1992 | 1593914 | Yes |
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45 | 21724 | 10862.0 | 477.49 | 238.7 | Coot: model-building tools for molecular graphics. | Paul Emsley, Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2004 | 15572765 | Yes |
46 | 21568 | 10784.0 | 562.91 | 281.5 | A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. | A P Feinberg, B Vogelstein | Anal Biochem | 1983 | 6312838 | Yes |
47 | 21410 | 10705.0 | 592.5 | 296.2 | Fast and accurate short read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2009 | 19451168 | Yes |
48 | 10473 | 10473.0 | 354.07 | 354.1 | Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). | J F Kurtzke | Neurology | 1983 | 6685237 | Yes |
49 | 10325 | 10325.0 | 0.0 | 0.0 | Improvements in epoxy resin embedding methods. | J H Luft | J Biophys Biochem Cytol | 1961 | 13764136 | Yes |
50 | 10179 | 10179.0 | 0.0 | 0.0 | The genetics of Caenorhabditis elegans. | S Brenner | Genetics | 1974 | 4366476 | Yes |
51 | 10137 | 10137.0 | 367.7 | 367.7 | Search and clustering orders of magnitude faster than BLAST. | Robert C Edgar | Bioinformatics | 2010 | 20709691 | Yes |
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53 | 10090 | 10090.0 | 389.27 | 389.3 | Structure validation in chemical crystallography. | Anthony L Spek | Acta Crystallogr D Biol Crystallogr | 2009 | 19171970 | Yes |
54 | 10070 | 10070.0 | 310.9 | 310.9 | The Psychophysics Toolbox. | D H Brainard | Spat Vis | 1997 | 9176952 | Yes |
55 | 19935 | 9967.5 | 725.89 | 362.9 | Fast gapped-read alignment with Bowtie 2. | Ben Langmead, Steven L Salzberg | Nat Methods | 2012 | 22388286 | Yes |
56 | 19869 | 9934.5 | 0.0 | 0.0 | The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. | K Weber, M Osborn | J Biol Chem | 1969 | 5806584 | Yes |
57 | 9851 | 9851.0 | 281.89 | 281.9 | Xds. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124692 | Yes |
58 | 9738 | 9738.0 | 0.0 | 0.0 | Self-efficacy: toward a unifying theory of behavioral change. | A Bandura | Psychol Rev | 1977 | 847061 | Yes |
59 | 9484 | 9484.0 | 325.09 | 325.1 | Banting lecture 1988. Role of insulin resistance in human disease. | G M Reaven | Diabetes | 1988 | 3056758 | No |
60 | 9318 | 9318.0 | 366.28 | 366.3 | A new method for measuring daytime sleepiness: the Epworth sleepiness scale. | M W Johns | Sleep | 1991 | 1798888 | Yes |
61 | 9249 | 9249.0 | 269.78 | 269.8 | Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. | P S Thomas | Proc Natl Acad Sci U S A | 1980 | 6159641 | Yes |
62 | 9217 | 9217.0 | 610.63 | 610.6 | Crystal structure refinement with SHELXL. | George M Sheldrick | Acta Crystallogr C Struct Chem | 2015 | 25567568 | Yes |
63 | 9110 | 9110.0 | 243.46 | 243.5 | Studies on transformation of Escherichia coli with plasmids. | D Hanahan | J Mol Biol | 1983 | 6345791 | Yes |
64 | 18208 | 9104.0 | 478.61 | 239.3 | A simple method for displaying the hydropathic character of a protein. | J Kyte, R F Doolittle | J Mol Biol | 1982 | 7108955 | Yes |
65 | 18129 | 9064.5 | 821.08 | 410.5 | The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. | R M Baron, D A Kenny | J Pers Soc Psychol | 1986 | 3806354 | Yes |
66 | 9056 | 9056.0 | 260.2 | 260.2 | The pathogenesis of atherosclerosis: a perspective for the 1990s. | R Ross | Nature | 1993 | 8479518 | No |
67 | 17955 | 8977.5 | 507.67 | 253.8 | Quantifying heterogeneity in a meta-analysis. | Julian P T Higgins, Simon G Thompson | Stat Med | 2002 | 12111919 | Yes |
68 | 8951 | 8951.0 | 235.94 | 235.9 | Integrins: versatility, modulation, and signaling in cell adhesion. | R O Hynes | Cell | 1992 | 1555235 | No |
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70 | 8645 | 8645.0 | 189.69 | 189.7 | Mfold web server for nucleic acid folding and hybridization prediction. | Michael Zuker | Nucleic Acids Res | 2003 | 12824337 | Yes |
71 | 8583 | 8583.0 | 245.63 | 245.6 | Evolutionary trees from DNA sequences: a maximum likelihood approach. | J Felsenstein | J Mol Evol | 1981 | 7288891 | Yes |
72 | 8510 | 8510.0 | 234.25 | 234.2 | RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. | Alexandros Stamatakis | Bioinformatics | 2006 | 16928733 | Yes |
73 | 8459 | 8459.0 | 0.0 | 0.0 | On the origin of cancer cells. | O Warburg | Science | 1956 | 13298683 | Yes |
74 | 8363 | 8363.0 | 261.53 | 261.5 | Vitamin D deficiency. | Michael F Holick | N Engl J Med | 2007 | 17634462 | No |
75 | 16471 | 8235.5 | 359.95 | 180.0 | The hallmarks of cancer. | D Hanahan, R A Weinberg | Cell | 2000 | 10647931 | No |
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77 | 8192 | 8192.0 | 174.97 | 175.0 | Linear models and empirical bayes methods for assessing differential expression in microarray experiments. | Gordon K Smyth | Stat Appl Genet Mol Biol | 2004 | 16646809 | Yes |
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79 | 8047 | 8047.0 | 360.23 | 360.2 | Psychophysical bases of perceived exertion. | G A Borg | Med Sci Sports Exerc | 1982 | 7154893 | Yes |
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81 | 7822 | 7822.0 | 173.32 | 173.3 | The functions of animal microRNAs. | Victor Ambros | Nature | 2004 | 15372042 | No |
82 | 7769 | 7769.0 | 218.45 | 218.4 | The role of protein kinase C in cell surface signal transduction and tumour promotion. | Y Nishizuka | Nature | 1984 | 6232463 | No |
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84 | 7695 | 7695.0 | 0.0 | 0.0 | A simplification of the protein assay method of Lowry et al. which is more generally applicable. | G L Peterson | Anal Biochem | 1977 | 603028 | Yes |
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89 | 7561 | 7561.0 | 205.16 | 205.2 | Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. | M C Hochberg | Arthritis Rheum | 1997 | 9324032 | Yes |
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1885 | 2805 | 1402.5 | 100.55 | 50.3 | The Oswestry Disability Index. | J C Fairbank, P B Pynsent | Spine (Phila Pa 1976) | 2000 | 11074683 | No |
1886 | 4207 | 1402.3 | 144.95 | 48.3 | Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. | Helga Thorvaldsdóttir, James T Robinson, Jill P Mesirov | Brief Bioinform | 2013 | 22517427 | Yes |
1887 | 2804 | 1402.0 | 59.19 | 29.6 | Fitting a mixture model by expectation maximization to discover motifs in biopolymers. | T L Bailey, C Elkan | Proc Int Conf Intell Syst Mol Biol | 1994 | 7584402 | Yes |
1888 | 2803 | 1401.5 | 100.99 | 50.5 | Saliency, switching, attention and control: a network model of insula function. | Vinod Menon, Lucina Q Uddin | Brain Struct Funct | 2010 | 20512370 | No |
1889 | 1401 | 1401.0 | 73.25 | 73.2 | Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. | F E Zajac | Crit Rev Biomed Eng | 1989 | 2676342 | No |
1890 | 2801 | 1400.5 | 0.0 | 0.0 | The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. | J O'Keefe, J Dostrovsky | Brain Res | 1971 | 5124915 | Yes |
1891 | 2801 | 1400.5 | 60.34 | 30.2 | Coordination of circadian timing in mammals. | Steven M Reppert, David R Weaver | Nature | 2002 | 12198538 | No |
1892 | 1400 | 1400.0 | 0.0 | 0.0 | Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. | C A Barnes | J Comp Physiol Psychol | 1979 | 221551 | Yes |
1893 | 1400 | 1400.0 | 0.0 | 0.0 | The measurement of psychological androgyny. | S L Bem | J Consult Clin Psychol | 1974 | 4823550 | Yes |
1894 | 1400 | 1400.0 | 0.0 | 0.0 | Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. | J Wyman | Adv Protein Chem | 1964 | 14268785 | No |
1895 | 2799 | 1399.5 | 0.0 | 0.0 | The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. | E G Gray, V P Whittaker | J Anat | 1962 | 13901297 | Yes |
1896 | 6996 | 1399.2 | 152.78 | 30.6 | Site-directed mutagenesis by overlap extension using the polymerase chain reaction. | S N Ho, H D Hunt, R M Horton, J K Pullen, L R Pease | Gene | 1989 | 2744487 | Yes |
1897 | 1399 | 1399.0 | 0.0 | 0.0 | Human cardiovascular adjustments to exercise and thermal stress. | L B Rowell | Physiol Rev | 1974 | 4587247 | No |
1898 | 2796 | 1398.0 | 0.0 | 0.0 | Empirical predictions of protein conformation. | P Y Chou, G D Fasman | Annu Rev Biochem | 1978 | 354496 | No |
1899 | 1398 | 1398.0 | 35.4 | 35.4 | Myeloperoxidase: friend and foe. | Seymour J Klebanoff | J Leukoc Biol | 2005 | 15689384 | No |
1900 | 1398 | 1398.0 | 34.96 | 35.0 | Five rules for the evolution of cooperation. | Martin A Nowak | Science | 2006 | 17158317 | No |
1901 | 1398 | 1398.0 | 35.78 | 35.8 | The failing heart--an engine out of fuel. | Stefan Neubauer | N Engl J Med | 2007 | 17360992 | No |
1902 | 2795 | 1397.5 | 116.0 | 58.0 | Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. | A Y Finlay, G K Khan | Clin Exp Dermatol | 1994 | 8033378 | Yes |
1903 | 1397 | 1397.0 | 0.0 | 0.0 | Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. | K S McCully | Am J Pathol | 1969 | 5792556 | Yes |
1904 | 1396 | 1396.0 | 45.47 | 45.5 | Efficient analysis of experimental observations. | W J Dixon | Annu Rev Pharmacol Toxicol | 1980 | 7387124 | Yes |
1905 | 1396 | 1396.0 | 31.94 | 31.9 | Tumor metastasis: mechanistic insights and clinical challenges. | Patricia S Steeg | Nat Med | 2006 | 16892035 | No |
1906 | 1396 | 1396.0 | 49.0 | 49.0 | The polyvagal perspective. | Stephen W Porges | Biol Psychol | 2007 | 17049418 | No |
1907 | 2791 | 1395.5 | 93.02 | 46.5 | The efficiency of systematic sampling in stereology and its prediction. | H J Gundersen, E B Jensen | J Microsc | 1987 | 3430576 | Yes |
1908 | 2790 | 1395.0 | 85.92 | 43.0 | Intracellular pH. | A Roos, W F Boron | Physiol Rev | 1981 | 7012859 | No |
1909 | 1394 | 1394.0 | 57.29 | 57.3 | A structured interview guide for the Hamilton Depression Rating Scale. | J B Williams | Arch Gen Psychiatry | 1988 | 3395203 | Yes |
1910 | 1394 | 1394.0 | 33.96 | 34.0 | Two pathogenetic types of endometrial carcinoma. | J V Bokhman | Gynecol Oncol | 1983 | 6822361 | Yes |
1911 | 1394 | 1394.0 | 31.17 | 31.2 | Protein misfolding, evolution and disease. | C M Dobson | Trends Biochem Sci | 1999 | 10470028 | No |
1912 | 1394 | 1394.0 | 38.28 | 38.3 | Task switching. | Stephen Monsell | Trends Cogn Sci | 2003 | 12639695 | Yes |
1913 | 1394 | 1394.0 | 29.12 | 29.1 | RNA silencing in plants. | David Baulcombe | Nature | 2004 | 15372043 | No |
1914 | 2788 | 1394.0 | 0.0 | 0.0 | Brain stem reticular formation and activation of the EEG. | G Moruzzi, H W Magoun | Electroencephalogr Clin Neurophysiol | 1949 | 18421835 | Yes |
1915 | 1393 | 1393.0 | 33.16 | 33.2 | Functions of ceramide in coordinating cellular responses to stress. | Y A Hannun | Science | 1996 | 8943189 | No |
1916 | 2785 | 1392.5 | 0.0 | 0.0 | Mutations of Bacteria from Virus Sensitivity to Virus Resistance. | S E Luria, M Delbrück | Genetics | 1943 | 17247100 | Yes |
1917 | 5566 | 1391.5 | 126.26 | 31.6 | Probability-based protein identification by searching sequence databases using mass spectrometry data. | D N Perkins, D J Pappin, D M Creasy, J S Cottrell | Electrophoresis | 1999 | 10612281 | Yes |
1918 | 2782 | 1391.0 | 89.17 | 44.6 | Functional architecture of basal ganglia circuits: neural substrates of parallel processing. | G E Alexander, M D Crutcher | Trends Neurosci | 1990 | 1695401 | No |
1919 | 1391 | 1391.0 | 32.88 | 32.9 | Speculations on the functions of the major heat shock and glucose-regulated proteins. | H R Pelham | Cell | 1986 | 2944601 | Yes |
1920 | 1391 | 1391.0 | 40.41 | 40.4 | Isolation and cultivation of Lyme disease spirochetes. | A G Barbour | Yale J Biol Med | 1984 | 6393604 | Yes |
1921 | 2782 | 1391.0 | 64.8 | 32.4 | Lipopolysaccharide endotoxins. | Christian R H Raetz, Chris Whitfield | Annu Rev Biochem | 2002 | 12045108 | No |
1922 | 4172 | 1390.7 | 142.35 | 47.4 | Vascular endothelial cells synthesize nitric oxide from L-arginine. | R M Palmer, D S Ashton, S Moncada | Nature | 1988 | 3131684 | Yes |
1923 | 1390 | 1390.0 | 32.04 | 32.0 | The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. | M Takeichi | Development | 1988 | 3048970 | No |
1924 | 1390 | 1390.0 | 26.74 | 26.7 | Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. | M G Gustafsson | J Microsc | 2000 | 10810003 | Yes |
1925 | 1390 | 1390.0 | 0.0 | 0.0 | Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. | W C Schneider | J Biol Chem | 1948 | 18886166 | Yes |
1926 | 1389 | 1389.0 | 0.0 | 0.0 | Microbial ecology of the gastrointestinal tract. | D C Savage | Annu Rev Microbiol | 1977 | 334036 | No |
1927 | 1389 | 1389.0 | 31.58 | 31.6 | Cancer epigenomics: DNA methylomes and histone-modification maps. | Manel Esteller | Nat Rev Genet | 2007 | 17339880 | No |
1928 | 5554 | 1388.5 | 237.79 | 59.4 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | Int J Surg | 2010 | 20171303 | No |
1929 | 4165 | 1388.3 | 104.06 | 34.7 | Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. | Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck Ørntoft | Cancer Res | 2004 | 15289330 | Yes |
1930 | 2776 | 1388.0 | 0.0 | 0.0 | A method of trace iodination of proteins for immunologic studies. | P J McConahey, F J Dixon | Int Arch Allergy Appl Immunol | 1966 | 4160044 | Yes |
1931 | 1387 | 1387.0 | 26.57 | 26.6 | Ubiquitin-dependent protein degradation. | M Hochstrasser | Annu Rev Genet | 1996 | 8982460 | No |
1932 | 1387 | 1387.0 | 32.22 | 32.2 | Hematopoietic stem-cell transplantation. | Edward A Copelan | N Engl J Med | 2006 | 16641398 | No |
1933 | 1387 | 1387.0 | 42.59 | 42.6 | Surface plasmon resonance sensors for detection of chemical and biological species. | Jirí Homola | Chem Rev | 2008 | 18229953 | No |
1934 | 2773 | 1386.5 | 62.31 | 31.2 | An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. | A A Beg, D Baltimore | Science | 1996 | 8864118 | Yes |
1935 | 1386 | 1386.0 | 0.0 | 0.0 | Selection of successive tumour lines for metastasis. | I J Fidler | Nat New Biol | 1973 | 4512654 | Yes |
1936 | 1386 | 1386.0 | 39.95 | 40.0 | Leishmaniasis: current situation and new perspectives. | P Desjeux | Comp Immunol Microbiol Infect Dis | 2004 | 15225981 | No |
1937 | 2771 | 1385.5 | 72.04 | 36.0 | A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. | J Messing, J Vieira | Gene | 1982 | 6295880 | Yes |
1938 | 2771 | 1385.5 | 63.45 | 31.7 | Cancer metastasis: building a framework. | Gaorav P Gupta, Joan Massagué | Cell | 2006 | 17110329 | No |
1939 | 1385 | 1385.0 | 92.46 | 92.5 | The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. | F C Ewald | Clin Orthop Relat Res | 1989 | 2805502 | Yes |
1940 | 1385 | 1385.0 | 37.75 | 37.8 | A more meaningful scoring system for determining the severity of coronary heart disease. | G G Gensini | Am J Cardiol | 1983 | 6823874 | Yes |
1941 | 2768 | 1384.0 | 71.02 | 35.5 | CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. | D G Higgins, P M Sharp | Gene | 1988 | 3243435 | Yes |
1942 | 1384 | 1384.0 | 30.21 | 30.2 | Neurotrophins as synaptic modulators. | M M Poo | Nat Rev Neurosci | 2001 | 11253356 | No |
1943 | 2766 | 1383.0 | 85.02 | 42.5 | Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. | P J Basser, C Pierpaoli | J Magn Reson B | 1996 | 8661285 | Yes |
1944 | 1383 | 1383.0 | 35.43 | 35.4 | An economic method for the fluorescent labeling of PCR fragments. | M Schuelke | Nat Biotechnol | 2000 | 10657137 | Yes |
1945 | 2765 | 1382.5 | 73.39 | 36.7 | Obesity. | David W Haslam, W Philip T James | Lancet | 2005 | 16198769 | No |
1946 | 9674 | 1382.0 | 215.02 | 30.7 | Embryonic stem cell lines derived from human blastocysts. | J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M Jones | Science | 1998 | 9804556 | Yes |
1947 | 1382 | 1382.0 | 32.45 | 32.5 | Ordered porous materials for emerging applications. | Mark E Davis | Nature | 2002 | 12075343 | No |
1948 | 1382 | 1382.0 | 0.0 | 0.0 | Cerebral vascular accidents in patients over the age of 60. II. Prognosis. | J Rankin | Scott Med J | 1957 | 13432835 | Yes |
1949 | 1382 | 1382.0 | 0.0 | 0.0 | Potential, Impedance, And Rectification In Membranes. | D E Goldman | J Gen Physiol | 1943 | 19873371 | Yes |
1950 | 1381 | 1381.0 | 0.0 | 0.0 | Codon--anticodon pairing: the wobble hypothesis. | F H Crick | J Mol Biol | 1966 | 5969078 | Yes |
1951 | 1381 | 1381.0 | 39.04 | 39.0 | A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. | J Engel | Epilepsia | 2001 | 11422340 | Yes |
1952 | 2759 | 1379.5 | 169.23 | 84.6 | Rating systems in the evaluation of knee ligament injuries. | Y Tegner, J Lysholm | Clin Orthop Relat Res | 1985 | 4028566 | Yes |
1953 | 2759 | 1379.5 | 0.0 | 0.0 | Prediction of protein conformation. | P Y Chou, G D Fasman | Biochemistry | 1974 | 4358940 | Yes |
1954 | 1379 | 1379.0 | 37.27 | 37.3 | Cell and environment interactions in tumor microregions: the multicell spheroid model. | R M Sutherland | Science | 1988 | 2451290 | Yes |
1955 | 1377 | 1377.0 | 35.44 | 35.4 | Stress and hippocampal plasticity. | B S McEwen | Annu Rev Neurosci | 1999 | 10202533 | No |
1956 | 2753 | 1376.5 | 55.0 | 27.5 | The evolutionary fate and consequences of duplicate genes. | M Lynch, J S Conery | Science | 2000 | 11073452 | No |
1957 | 2752 | 1376.0 | 63.64 | 31.8 | NF-kappaB: a key role in inflammatory diseases. | P P Tak, G S Firestein | J Clin Invest | 2001 | 11134171 | No |
1958 | 1376 | 1376.0 | 29.26 | 29.3 | Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. | S S Ferguson | Pharmacol Rev | 2001 | 11171937 | No |
1959 | 1375 | 1375.0 | 36.56 | 36.6 | Use and misuse of the receiver operating characteristic curve in risk prediction. | Nancy R Cook | Circulation | 2007 | 17309939 | Yes |
1960 | 2749 | 1374.5 | 74.48 | 37.2 | Macrophage diversity enhances tumor progression and metastasis. | Bin-Zhi Qian, Jeffrey W Pollard | Cell | 2010 | 20371344 | No |
1961 | 1374 | 1374.0 | 31.87 | 31.9 | Protein kinase C: structure, function, and regulation. | A C Newton | J Biol Chem | 1995 | 7499357 | No |
1962 | 1374 | 1374.0 | 26.46 | 26.5 | NK cell receptors. | L L Lanier | Annu Rev Immunol | 1998 | 9597134 | No |
1963 | 1374 | 1374.0 | 33.76 | 33.8 | Neuronal synchrony: a versatile code for the definition of relations? | W Singer | Neuron | 1999 | 10677026 | No |
1964 | 1374 | 1374.0 | 49.34 | 49.3 | Matching methods for causal inference: A review and a look forward. | Elizabeth A Stuart | Stat Sci | 2010 | 20871802 | Yes |
1965 | 2747 | 1373.5 | 77.58 | 38.8 | Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. | B R Celli, W MacNee | Eur Respir J | 2004 | 15219010 | No |
1966 | 2747 | 1373.5 | 0.0 | 0.0 | The effect of sodium ions on the electrical activity of giant axon of the squid. | A L Hodgkin, B Katz | J Physiol | 1949 | 18128147 | Yes |
1967 | 6866 | 1373.2 | 298.25 | 59.6 | UCHIME improves sensitivity and speed of chimera detection. | Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob Knight | Bioinformatics | 2011 | 21700674 | Yes |
1968 | 1373 | 1373.0 | 33.32 | 33.3 | The basic science of gene therapy. | R C Mulligan | Science | 1993 | 8493530 | No |
1969 | 1373 | 1373.0 | 0.0 | 0.0 | An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. | O Smithies | Biochem J | 1959 | 13638269 | Yes |
1970 | 2745 | 1372.5 | 53.56 | 26.8 | T-cell antigen receptor genes and T-cell recognition. | M M Davis, P J Bjorkman | Nature | 1988 | 3043226 | No |
1971 | 1372 | 1372.0 | 0.0 | 0.0 | Effects of varying the vehicle for OsO4 in tissue fixation. | J B Caulfield | J Biophys Biochem Cytol | 1957 | 13475399 | Yes |
1972 | 1372 | 1372.0 | 45.29 | 45.3 | Stress signalling pathways that impair prefrontal cortex structure and function. | Amy F T Arnsten | Nat Rev Neurosci | 2009 | 19455173 | No |
1973 | 2742 | 1371.0 | 0.0 | 0.0 | Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. | A J Berk, P A Sharp | Cell | 1977 | 922889 | Yes |
1974 | 1371 | 1371.0 | 54.59 | 54.6 | Cardiac valve surgery--the "French correction". | A Carpentier | J Thorac Cardiovasc Surg | 1983 | 6887954 | Yes |
1975 | 2742 | 1371.0 | 76.59 | 38.3 | Transforming growth factor beta in tissue fibrosis. | W A Border, N A Noble | N Engl J Med | 1994 | 7935686 | No |
1976 | 4113 | 1371.0 | 97.65 | 32.6 | Click Chemistry: Diverse Chemical Function from a Few Good Reactions. | Hartmuth C. Kolb, M. G. Finn, K. Barry Sharpless | Angew Chem Int Ed Engl | 2001 | 11433435 | Yes |
1977 | 4113 | 1371.0 | 88.82 | 29.6 | Toll-like receptors. | Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira | Annu Rev Immunol | 2003 | 12524386 | No |
1978 | 2742 | 1371.0 | 0.0 | 0.0 | Immunoassay of endogenous plasma insulin in man. | R S Yalow, S A Berson | J Clin Invest | 1960 | 13846364 | Yes |
1979 | 1370 | 1370.0 | 34.42 | 34.4 | The use of nanocrystals in biological detection. | Paul Alivisatos | Nat Biotechnol | 2004 | 14704706 | Yes |
1980 | 4109 | 1369.7 | 91.53 | 30.5 | Telomeres shorten during ageing of human fibroblasts. | C B Harley, A B Futcher, C W Greider | Nature | 1990 | 2342578 | Yes |
1981 | 1369 | 1369.0 | 0.0 | 0.0 | Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. | S S Lehrer | Biochemistry | 1971 | 5119250 | Yes |
1982 | 2738 | 1369.0 | 70.96 | 35.5 | Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. | D Marion, K Wüthrich | Biochem Biophys Res Commun | 1983 | 6307308 | Yes |
1983 | 1369 | 1369.0 | 29.24 | 29.2 | The Buccaneer software for automated model building. 1. Tracing protein chains. | Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2006 | 16929101 | Yes |
1984 | 2737 | 1368.5 | 82.6 | 41.3 | Glycine potentiates the NMDA response in cultured mouse brain neurons. | J W Johnson, P Ascher | Nature | 1987 | 2433595 | Yes |
1985 | 1368 | 1368.0 | 45.85 | 45.9 | Interleukin-1. | C A Dinarello | Rev Infect Dis | 1984 | 6369481 | No |
1986 | 1368 | 1368.0 | 36.47 | 36.5 | Hydrogels for biomedical applications. | Allan S Hoffman | Adv Drug Deliv Rev | 2002 | 11755703 | No |
1987 | 4104 | 1368.0 | 91.77 | 30.6 | TOR signaling in growth and metabolism. | Stephan Wullschleger, Robbie Loewith, Michael N Hall | Cell | 2006 | 16469695 | No |
1988 | 1367 | 1367.0 | 43.83 | 43.8 | Equipoise and the ethics of clinical research. | B Freedman | N Engl J Med | 1987 | 3600702 | Yes |
1989 | 1367 | 1367.0 | 28.01 | 28.0 | Macromolecular crowding: obvious but underappreciated. | R J Ellis | Trends Biochem Sci | 2001 | 11590012 | No |
1990 | 5468 | 1367.0 | 311.39 | 77.8 | IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. | Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang Minh | Mol Biol Evol | 2015 | 25371430 | Yes |
1991 | 1366 | 1366.0 | 40.76 | 40.8 | The aging process. | D Harman | Proc Natl Acad Sci U S A | 1981 | 6947277 | Yes |
1992 | 2731 | 1365.5 | 99.87 | 49.9 | Biology of disease: free radicals and tissue injury. | B A Freeman, J D Crapo | Lab Invest | 1982 | 6290784 | No |
1993 | 2730 | 1365.0 | 69.76 | 34.9 | Unravelling the pathogenesis of inflammatory bowel disease. | R J Xavier, D K Podolsky | Nature | 2007 | 17653185 | No |
1994 | 2726 | 1363.0 | 88.95 | 44.5 | Unidentified curved bacilli on gastric epithelium in active chronic gastritis. | J R Warren, B Marshall | Lancet | 1983 | 6134060 | Yes |
1995 | 1362 | 1362.0 | 30.61 | 30.6 | Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. | M Kozak | Microbiol Rev | 1983 | 6343825 | No |
1996 | 1362 | 1362.0 | 56.53 | 56.5 | Sample size in qualitative research. | M Sandelowski | Res Nurs Health | 1995 | 7899572 | Yes |
1997 | 2723 | 1361.5 | 61.7 | 30.9 | Self-assembly at all scales. | George M Whitesides, Bartosz Grzybowski | Science | 2002 | 11923529 | Yes |
1998 | 1361 | 1361.0 | 47.93 | 47.9 | Multiple calcium channels and neuronal function. | R J Miller | Science | 1987 | 2432656 | No |
1999 | 2720 | 1360.0 | 86.2 | 43.1 | Performing the exact test of Hardy-Weinberg proportion for multiple alleles. | S W Guo, E A Thompson | Biometrics | 1992 | 1637966 | Yes |
2000 | 1360 | 1360.0 | 33.48 | 33.5 | Oxidative stress in Parkinson's disease. | Peter Jenner | Ann Neurol | 2003 | 12666096 | No |
2001 | 2719 | 1359.5 | 84.22 | 42.1 | From best evidence to best practice: effective implementation of change in patients' care. | Richard Grol, Jeremy Grimshaw | Lancet | 2003 | 14568747 | No |
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2005 | 1358 | 1358.0 | 32.74 | 32.7 | Neurotrophin-regulated signalling pathways. | Louis F Reichardt | Philos Trans R Soc Lond B Biol Sci | 2006 | 16939974 | No |
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2007 | 2714 | 1357.0 | 0.0 | 0.0 | A protein sequenator. | P Edman, G Begg | Eur J Biochem | 1967 | 6059350 | Yes |
2008 | 1356 | 1356.0 | 49.05 | 49.0 | Colorimetric determination of phospholipids with ammonium ferrothiocyanate. | J C Stewart | Anal Biochem | 1980 | 6892980 | Yes |
2009 | 2711 | 1355.5 | 84.28 | 42.1 | Protective and pathogenic functions of macrophage subsets. | Peter J Murray, Thomas A Wynn | Nat Rev Immunol | 2011 | 21997792 | No |
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2011 | 1354 | 1354.0 | 48.58 | 48.6 | The global impact of pre-eclampsia and eclampsia. | Lelia Duley | Semin Perinatol | 2009 | 19464502 | No |
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2014 | 1351 | 1351.0 | 25.38 | 25.4 | The DNA methyltransferases of mammals. | T H Bestor | Hum Mol Genet | 2000 | 11005794 | No |
2015 | 5401 | 1350.2 | 144.19 | 36.0 | Most mammalian mRNAs are conserved targets of microRNAs. | Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel | Genome Res | 2009 | 18955434 | Yes |
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2017 | 1349 | 1349.0 | 34.96 | 35.0 | The amygdala modulates the consolidation of memories of emotionally arousing experiences. | James L McGaugh | Annu Rev Neurosci | 2004 | 15217324 | No |
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2019 | 2694 | 1347.0 | 0.0 | 0.0 | Selective loss of central cholinergic neurons in Alzheimer's disease. | P Davies, A J Maloney | Lancet | 1976 | 63862 | Yes |
2020 | 2694 | 1347.0 | 77.46 | 38.7 | Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. | F D Lublin, S C Reingold | Neurology | 1996 | 8780061 | Yes |
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2023 | 2691 | 1345.5 | 0.0 | 0.0 | Synchronization of Plasmodium falciparum erythrocytic stages in culture. | C Lambros, J P Vanderberg | J Parasitol | 1979 | 383936 | Yes |
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2025 | 2690 | 1345.0 | 68.09 | 34.0 | Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. | M D Pierschbacher, E Ruoslahti | Nature | 1984 | 6325925 | Yes |
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