No. | Citations | ECcit | RCR | ECRCR | Title | Authors | Journal | Year | PMID | Article(?) |
---|---|---|---|---|---|---|---|---|---|---|
1 | 221515 | 221515.0 | 0.0 | 0.0 | Cleavage of structural proteins during the assembly of the head of bacteriophage T4. | U K Laemmli | Nature | 1970 | 5432063 | Yes |
2 | 168357 | 168357.0 | 0.0 | 0.0 | A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. | M M Bradford | Anal Biochem | 1976 | 942051 | Yes |
3 | 285734 | 71433.5 | 0.0 | 0.0 | Protein measurement with the Folin phenol reagent. | O H Lowry, N J Rosebrough, A L Farr, R J Randall | J Biol Chem | 1951 | 14907713 | Yes |
4 | 96300 | 48150.0 | 2481.91 | 1241.0 | Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. | K J Livak, T D Schmittgen | Methods | 2001 | 11846609 | Yes |
5 | 42965 | 42965.0 | 1452.94 | 1452.9 | A short history of SHELX. | George M Sheldrick | Acta Crystallogr A | 2008 | 18156677 | Yes |
6 | 33598 | 33598.0 | 1091.08 | 1091.1 | Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. | T Mosmann | J Immunol Methods | 1983 | 6606682 | Yes |
7 | 65082 | 32541.0 | 1973.67 | 986.8 | Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. | P Chomczynski, N Sacchi | Anal Biochem | 1987 | 2440339 | Yes |
8 | 30167 | 30167.0 | 0.0 | 0.0 | Detection of specific sequences among DNA fragments separated by gel electrophoresis. | E M Southern | J Mol Biol | 1975 | 1195397 | Yes |
9 | 25336 | 25336.0 | 0.0 | 0.0 | The assessment and analysis of handedness: the Edinburgh inventory. | R C Oldfield | Neuropsychologia | 1971 | 5146491 | Yes |
10 | 24855 | 24855.0 | 575.79 | 575.8 | MicroRNAs: genomics, biogenesis, mechanism, and function. | David P Bartel | Cell | 2004 | 14744438 | No |
11 | 23577 | 23577.0 | 0.0 | 0.0 | A rating scale for depression. | M Hamilton | J Neurol Neurosurg Psychiatry | 1960 | 14399272 | Yes |
12 | 22332 | 22332.0 | 701.74 | 701.7 | Confidence Limits On Phylogenies: An Approach Using The Bootstrap. | Joseph Felsenstein | Evolution | 1985 | 28561359 | Yes |
13 | 65336 | 21778.7 | 0.0 | 0.0 | DNA sequencing with chain-terminating inhibitors. | F Sanger, S Nicklen, A R Coulson | Proc Natl Acad Sci U S A | 1977 | 271968 | Yes |
14 | 21552 | 21552.0 | 536.01 | 536.0 | MUSCLE: multiple sequence alignment with high accuracy and high throughput. | Robert C Edgar | Nucleic Acids Res | 2004 | 15034147 | Yes |
15 | 21406 | 21406.0 | 510.24 | 510.2 | A new mathematical model for relative quantification in real-time RT-PCR. | M W Pfaffl | Nucleic Acids Res | 2001 | 11328886 | Yes |
16 | 60151 | 20050.3 | 0.0 | 0.0 | "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. | M F Folstein, S E Folstein, P R McHugh | J Psychiatr Res | 1975 | 1202204 | Yes |
17 | 19937 | 19937.0 | 0.0 | 0.0 | The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. | E S Reynolds | J Cell Biol | 1963 | 13986422 | Yes |
18 | 36730 | 18365.0 | 1139.67 | 569.8 | The neighbor-joining method: a new method for reconstructing phylogenetic trees. | N Saitou, M Nei | Mol Biol Evol | 1987 | 3447015 | Yes |
19 | 18183 | 18183.0 | 646.67 | 646.7 | Density-functional exchange-energy approximation with correct asymptotic behavior. | Becke | Phys Rev A Gen Phys | 1988 | 9900728 | Yes |
20 | 18091 | 18091.0 | 0.0 | 0.0 | Tissue sulfhydryl groups. | G L Ellman | Arch Biochem Biophys | 1959 | 13650640 | Yes |
21 | 53130 | 17710.0 | 0.0 | 0.0 | Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. | H Towbin, T Staehelin, J Gordon | Proc Natl Acad Sci U S A | 1979 | 388439 | Yes |
22 | 16797 | 16797.0 | 0.0 | 0.0 | Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. | B J Davis | Ann N Y Acad Sci | 1964 | 14240539 | Yes |
23 | 33399 | 16699.5 | 1616.41 | 808.2 | Statistical methods for assessing agreement between two methods of clinical measurement. | J M Bland, D G Altman | Lancet | 1986 | 2868172 | Yes |
24 | 16399 | 16399.0 | 0.0 | 0.0 | High resolution two-dimensional electrophoresis of proteins. | P H O'Farrell | J Biol Chem | 1975 | 236308 | Yes |
25 | 32458 | 16229.0 | 1154.53 | 577.3 | Hallmarks of cancer: the next generation. | Douglas Hanahan, Robert A Weinberg | Cell | 2011 | 21376230 | No |
26 | 16088 | 16088.0 | 419.45 | 419.4 | Atherosclerosis--an inflammatory disease. | R Ross | N Engl J Med | 1999 | 9887164 | No |
27 | 15898 | 15898.0 | 0.0 | 0.0 | A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. | K Burton | Biochem J | 1956 | 13293190 | Yes |
28 | 15350 | 15350.0 | 573.89 | 573.9 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. | M Kimura | J Mol Evol | 1980 | 7463489 | Yes |
29 | 30632 | 15316.0 | 0.0 | 0.0 | A rapid method of total lipid extraction and purification. | E G Bligh, W J Dyer | Can J Biochem Physiol | 1959 | 13671378 | Yes |
30 | 29276 | 14638.0 | 0.0 | 0.0 | The measurement of observer agreement for categorical data. | J R Landis, G G Koch | Biometrics | 1977 | 843571 | Yes |
31 | 43353 | 14451.0 | 1254.22 | 418.1 | CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. | J D Thompson, D G Higgins, T J Gibson | Nucleic Acids Res | 1994 | 7984417 | Yes |
32 | 41071 | 13690.3 | 0.0 | 0.0 | A simple method for the isolation and purification of total lipides from animal tissues. | J Folch, M Lees, G H Sloane Stanley | J Biol Chem | 1957 | 13428781 | Yes |
33 | 13450 | 13450.0 | 370.89 | 370.9 | MicroRNAs: target recognition and regulatory functions. | David P Bartel | Cell | 2009 | 19167326 | No |
34 | 12983 | 12983.0 | 385.15 | 385.1 | Projector augmented-wave method. | Blöchl | Phys Rev B Condens Matter | 1994 | 9976227 | Yes |
35 | 12931 | 12931.0 | 547.84 | 547.8 | A power primer. | J Cohen | Psychol Bull | 1992 | 19565683 | Yes |
36 | 25588 | 12794.0 | 984.53 | 492.3 | Meta-analysis in clinical trials. | R DerSimonian, N Laird | Control Clin Trials | 1986 | 3802833 | Yes |
37 | 12705 | 12705.0 | 0.0 | 0.0 | Phosphorus assay in column chromatography. | G R Bartlett | J Biol Chem | 1959 | 13641241 | Yes |
38 | 25029 | 12514.5 | 1040.28 | 520.1 | The hospital anxiety and depression scale. | A S Zigmond, R P Snaith | Acta Psychiatr Scand | 1983 | 6880820 | Yes |
39 | 12050 | 12050.0 | 479.07 | 479.1 | Catalase in vitro. | H Aebi | Methods Enzymol | 1984 | 6727660 | Yes |
40 | 11666 | 11666.0 | 613.8 | 613.8 | RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. | Alexandros Stamatakis | Bioinformatics | 2014 | 24451623 | Yes |
41 | 33553 | 11184.3 | 1043.09 | 347.7 | Generalized Gradient Approximation Made Simple. | Perdew, Burke, Ernzerhof | Phys Rev Lett | 1996 | 10062328 | Yes |
42 | 55441 | 11088.2 | 1603.48 | 320.7 | Basic local alignment search tool. | S F Altschul, W Gish, W Miller, E W Myers, D J Lipman | J Mol Biol | 1990 | 2231712 | Yes |
43 | 22078 | 11039.0 | 936.44 | 468.2 | The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. | J E Ware, C D Sherbourne | Med Care | 1992 | 1593914 | Yes |
44 | 21560 | 10780.0 | 562.4 | 281.2 | A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. | A P Feinberg, B Vogelstein | Anal Biochem | 1983 | 6312838 | Yes |
45 | 21511 | 10755.5 | 474.97 | 237.5 | Coot: model-building tools for molecular graphics. | Paul Emsley, Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2004 | 15572765 | Yes |
46 | 32154 | 10718.0 | 1177.34 | 392.4 | Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. | Lee, Yang, Parr | Phys Rev B Condens Matter | 1988 | 9944570 | Yes |
47 | 20827 | 10413.5 | 580.45 | 290.2 | Fast and accurate short read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2009 | 19451168 | Yes |
48 | 10387 | 10387.0 | 351.18 | 351.2 | Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). | J F Kurtzke | Neurology | 1983 | 6685237 | Yes |
49 | 10314 | 10314.0 | 0.0 | 0.0 | Improvements in epoxy resin embedding methods. | J H Luft | J Biophys Biochem Cytol | 1961 | 13764136 | Yes |
50 | 10063 | 10063.0 | 393.79 | 393.8 | Structure validation in chemical crystallography. | Anthony L Spek | Acta Crystallogr D Biol Crystallogr | 2009 | 19171970 | Yes |
51 | 10060 | 10060.0 | 0.0 | 0.0 | The genetics of Caenorhabditis elegans. | S Brenner | Genetics | 1974 | 4366476 | Yes |
52 | 19963 | 9981.5 | 0.0 | 0.0 | The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. | K Weber, M Osborn | J Biol Chem | 1969 | 5806584 | Yes |
53 | 19917 | 9958.5 | 449.16 | 224.6 | [20] Processing of X-ray diffraction data collected in oscillation mode. | Zbyszek Otwinowski, Wladek Minor | Methods Enzymol | 1997 | 27799103 | Yes |
54 | 9957 | 9957.0 | 308.32 | 308.3 | The Psychophysics Toolbox. | D H Brainard | Spat Vis | 1997 | 9176952 | Yes |
55 | 9906 | 9906.0 | 363.62 | 363.6 | Search and clustering orders of magnitude faster than BLAST. | Robert C Edgar | Bioinformatics | 2010 | 20709691 | Yes |
56 | 9696 | 9696.0 | 280.22 | 280.2 | Xds. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124692 | Yes |
57 | 9636 | 9636.0 | 0.0 | 0.0 | Self-efficacy: toward a unifying theory of behavioral change. | A Bandura | Psychol Rev | 1977 | 847061 | Yes |
58 | 19220 | 9610.0 | 708.06 | 354.0 | Fast gapped-read alignment with Bowtie 2. | Ben Langmead, Steven L Salzberg | Nat Methods | 2012 | 22388286 | Yes |
59 | 9464 | 9464.0 | 324.97 | 325.0 | Banting lecture 1988. Role of insulin resistance in human disease. | G M Reaven | Diabetes | 1988 | 3056758 | No |
60 | 9248 | 9248.0 | 269.92 | 269.9 | Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. | P S Thomas | Proc Natl Acad Sci U S A | 1980 | 6159641 | Yes |
61 | 9182 | 9182.0 | 361.39 | 361.4 | A new method for measuring daytime sleepiness: the Epworth sleepiness scale. | M W Johns | Sleep | 1991 | 1798888 | Yes |
62 | 9085 | 9085.0 | 242.75 | 242.8 | Studies on transformation of Escherichia coli with plasmids. | D Hanahan | J Mol Biol | 1983 | 6345791 | Yes |
63 | 18140 | 9070.0 | 476.95 | 238.5 | A simple method for displaying the hydropathic character of a protein. | J Kyte, R F Doolittle | J Mol Biol | 1982 | 7108955 | Yes |
64 | 9044 | 9044.0 | 260.16 | 260.2 | The pathogenesis of atherosclerosis: a perspective for the 1990s. | R Ross | Nature | 1993 | 8479518 | No |
65 | 18008 | 9004.0 | 816.7 | 408.4 | The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. | R M Baron, D A Kenny | J Pers Soc Psychol | 1986 | 3806354 | Yes |
66 | 8939 | 8939.0 | 235.97 | 236.0 | Integrins: versatility, modulation, and signaling in cell adhesion. | R O Hynes | Cell | 1992 | 1555235 | No |
67 | 8897 | 8897.0 | 605.74 | 605.7 | Crystal structure refinement with SHELXL. | George M Sheldrick | Acta Crystallogr C Struct Chem | 2015 | 25567568 | Yes |
68 | 17561 | 8780.5 | 498.18 | 249.1 | Quantifying heterogeneity in a meta-analysis. | Julian P T Higgins, Simon G Thompson | Stat Med | 2002 | 12111919 | Yes |
69 | 8568 | 8568.0 | 188.53 | 188.5 | Mfold web server for nucleic acid folding and hybridization prediction. | Michael Zuker | Nucleic Acids Res | 2003 | 12824337 | Yes |
70 | 8482 | 8482.0 | 242.0 | 242.0 | Evolutionary trees from DNA sequences: a maximum likelihood approach. | J Felsenstein | J Mol Evol | 1981 | 7288891 | Yes |
71 | 16857 | 8428.5 | 490.74 | 245.4 | Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. | Kresse, Furthmüller | Phys Rev B Condens Matter | 1996 | 9984901 | Yes |
72 | 8413 | 8413.0 | 233.34 | 233.3 | RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. | Alexandros Stamatakis | Bioinformatics | 2006 | 16928733 | Yes |
73 | 8338 | 8338.0 | 0.0 | 0.0 | On the origin of cancer cells. | O Warburg | Science | 1956 | 13298683 | Yes |
74 | 8292 | 8292.0 | 261.46 | 261.5 | Vitamin D deficiency. | Michael F Holick | N Engl J Med | 2007 | 17634462 | No |
75 | 16315 | 8157.5 | 357.26 | 178.6 | The hallmarks of cancer. | D Hanahan, R A Weinberg | Cell | 2000 | 10647931 | No |
76 | 8118 | 8118.0 | 174.16 | 174.2 | Linear models and empirical bayes methods for assessing differential expression in microarray experiments. | Gordon K Smyth | Stat Appl Genet Mol Biol | 2004 | 16646809 | Yes |
77 | 24081 | 8027.0 | 643.8 | 214.6 | VMD: visual molecular dynamics. | W Humphrey, A Dalke, K Schulten | J Mol Graph | 1996 | 8744570 | Yes |
78 | 7984 | 7984.0 | 0.0 | 0.0 | Solvent content of protein crystals. | B W Matthews | J Mol Biol | 1968 | 5700707 | Yes |
79 | 7969 | 7969.0 | 357.57 | 357.6 | Psychophysical bases of perceived exertion. | G A Borg | Med Sci Sports Exerc | 1982 | 7154893 | Yes |
80 | 31517 | 7879.2 | 952.36 | 238.1 | Measuring inconsistency in meta-analyses. | Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman | BMJ | 2003 | 12958120 | No |
81 | 7768 | 7768.0 | 218.63 | 218.6 | The role of protein kinase C in cell surface signal transduction and tumour promotion. | Y Nishizuka | Nature | 1984 | 6232463 | No |
82 | 7750 | 7750.0 | 172.29 | 172.3 | The functions of animal microRNAs. | Victor Ambros | Nature | 2004 | 15372042 | No |
83 | 7746 | 7746.0 | 218.38 | 218.4 | "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. | W N Burnette | Anal Biochem | 1981 | 6266278 | Yes |
84 | 7689 | 7689.0 | 0.0 | 0.0 | A simplification of the protein assay method of Lowry et al. which is more generally applicable. | G L Peterson | Anal Biochem | 1977 | 603028 | Yes |
85 | 7567 | 7567.0 | 0.0 | 0.0 | Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. | J R Vane | Nat New Biol | 1971 | 5284360 | Yes |
86 | 7524 | 7524.0 | 0.0 | 0.0 | Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. | D I Arnon | Plant Physiol | 1949 | 16654194 | Yes |
87 | 7470 | 7470.0 | 218.71 | 218.7 | Semiempirical GGA-type density functional constructed with a long-range dispersion correction. | Stefan Grimme | J Comput Chem | 2006 | 16955487 | Yes |
88 | 7468 | 7468.0 | 203.35 | 203.3 | Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. | M C Hochberg | Arthritis Rheum | 1997 | 9324032 | Yes |
89 | 14858 | 7429.0 | 351.54 | 175.8 | Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. | Kazutoshi Takahashi, Shinya Yamanaka | Cell | 2006 | 16904174 | Yes |
90 | 29325 | 7331.2 | 1123.25 | 280.8 | A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. | M E Charlson, P Pompei, K L Ales, C R MacKenzie | J Chronic Dis | 1987 | 3558716 | Yes |
91 | 29268 | 7317.0 | 1264.5 | 316.1 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | PLoS Med | 2009 | 19621072 | No |
92 | 21780 | 7260.0 | 615.9 | 205.3 | Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nat Protoc | 2009 | 19131956 | Yes |
93 | 7239 | 7239.0 | 0.0 | 0.0 | A low-viscosity epoxy resin embedding medium for electron microscopy. | A R Spurr | J Ultrastruct Res | 1969 | 4887011 | Yes |
94 | 7090 | 7090.0 | 0.0 | 0.0 | Tumor angiogenesis: therapeutic implications. | J Folkman | N Engl J Med | 1971 | 4938153 | No |
95 | 14141 | 7070.5 | 359.2 | 179.6 | MrBayes 3: Bayesian phylogenetic inference under mixed models. | Fredrik Ronquist, John P Huelsenbeck | Bioinformatics | 2003 | 12912839 | Yes |
96 | 6998 | 6998.0 | 0.0 | 0.0 | Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. | A Böyum | Scand J Clin Lab Invest Suppl | 1968 | 4179068 | Yes |
97 | 6996 | 6996.0 | 193.87 | 193.9 | TreeView: an application to display phylogenetic trees on personal computers. | R D Page | Comput Appl Biosci | 1996 | 8902363 | Yes |
98 | 20808 | 6936.0 | 814.99 | 271.7 | NIH Image to ImageJ: 25 years of image analysis. | Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri | Nat Methods | 2012 | 22930834 | No |
99 | 20740 | 6913.3 | 919.13 | 306.4 | Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. | Michael I Love, Wolfgang Huber, Simon Anders | Genome Biol | 2014 | 25516281 | Yes |
100 | 20738 | 6912.7 | 0.0 | 0.0 | Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. | W T Friedewald, R I Levy, D S Fredrickson | Clin Chem | 1972 | 4337382 | Yes |
101 | 48256 | 6893.7 | 1275.31 | 182.2 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. | S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J Lipman | Nucleic Acids Res | 1997 | 9254694 | No |
102 | 6881 | 6881.0 | 209.37 | 209.4 | AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. | R W Cox | Comput Biomed Res | 1996 | 8812068 | Yes |
103 | 27500 | 6875.0 | 917.35 | 229.3 | Bias in meta-analysis detected by a simple, graphical test. | M Egger, G Davey Smith, M Schneider, C Minder | BMJ | 1997 | 9310563 | Yes |
104 | 6849 | 6849.0 | 234.3 | 234.3 | The blockade of immune checkpoints in cancer immunotherapy. | Drew M Pardoll | Nat Rev Cancer | 2012 | 22437870 | No |
105 | 6846 | 6846.0 | 270.25 | 270.2 | Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. | Andreas Stang | Eur J Epidemiol | 2010 | 20652370 | Yes |
106 | 13644 | 6822.0 | 390.81 | 195.4 | Analyzing real-time PCR data by the comparative C(T) method. | Thomas D Schmittgen, Kenneth J Livak | Nat Protoc | 2008 | 18546601 | Yes |
107 | 6797 | 6797.0 | 186.59 | 186.6 | Canonical dynamics: Equilibrium phase-space distributions. | Hoover | Phys Rev A Gen Phys | 1985 | 9895674 | Yes |
108 | 6796 | 6796.0 | 232.45 | 232.4 | Density-functional approximation for the correlation energy of the inhomogeneous electron gas. | Perdew | Phys Rev B Condens Matter | 1986 | 9938299 | Yes |
109 | 6775 | 6775.0 | 0.0 | 0.0 | The thiobarbituric acid assay of sialic acids. | L Warren | J Biol Chem | 1959 | 13672998 | Yes |
110 | 6746 | 6746.0 | 184.09 | 184.1 | The steroid and thyroid hormone receptor superfamily. | R M Evans | Science | 1988 | 3283939 | No |
111 | 13458 | 6729.0 | 0.0 | 0.0 | Continuous cultures of fused cells secreting antibody of predefined specificity. | G Köhler, C Milstein | Nature | 1975 | 1172191 | Yes |
112 | 6721 | 6721.0 | 175.12 | 175.1 | PAML 4: phylogenetic analysis by maximum likelihood. | Ziheng Yang | Mol Biol Evol | 2007 | 17483113 | Yes |
113 | 6713 | 6713.0 | 155.32 | 155.3 | Chromatin modifications and their function. | Tony Kouzarides | Cell | 2007 | 17320507 | No |
114 | 13344 | 6672.0 | 287.66 | 143.8 | Processing of X-ray diffraction data collected in oscillation mode. | Z Otwinowski, W Minor | Methods Enzymol | 1997 | 27754618 | Yes |
115 | 6663 | 6663.0 | 179.95 | 179.9 | Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. | F Tajima | Genetics | 1989 | 2513255 | Yes |
116 | 19861 | 6620.3 | 567.25 | 189.1 | A new generation of Ca2+ indicators with greatly improved fluorescence properties. | G Grynkiewicz, M Poenie, R Y Tsien | J Biol Chem | 1985 | 3838314 | Yes |
117 | 6610 | 6610.0 | 315.45 | 315.4 | Comparative fit indexes in structural models. | P M Bentler | Psychol Bull | 1990 | 2320703 | Yes |
118 | 13018 | 6509.0 | 301.19 | 150.6 | Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. | S J Clough, A F Bent | Plant J | 1998 | 10069079 | Yes |
119 | 6494 | 6494.0 | 172.69 | 172.7 | Adhesion receptors of the immune system. | T A Springer | Nature | 1990 | 1974032 | No |
120 | 6447 | 6447.0 | 0.0 | 0.0 | The assessment of anxiety states by rating. | M Hamilton | Br J Med Psychol | 1959 | 13638508 | Yes |
121 | 6416 | 6416.0 | 166.69 | 166.7 | Fast robust automated brain extraction. | Stephen M Smith | Hum Brain Mapp | 2002 | 12391568 | No |
122 | 6383 | 6383.0 | 169.59 | 169.6 | Angiogenesis in cancer, vascular, rheumatoid and other disease. | J Folkman | Nat Med | 1995 | 7584949 | No |
123 | 6354 | 6354.0 | 130.14 | 130.1 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel | Proc Natl Acad Sci U S A | 1985 | 3881765 | Yes |
124 | 12690 | 6345.0 | 582.9 | 291.4 | MAFFT multiple sequence alignment software version 7: improvements in performance and usability. | Kazutaka Katoh, Daron M Standley | Mol Biol Evol | 2013 | 23329690 | Yes |
125 | 12685 | 6342.5 | 0.0 | 0.0 | Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. | Y Cheng, W H Prusoff | Biochem Pharmacol | 1973 | 4202581 | Yes |
126 | 12618 | 6309.0 | 280.38 | 140.2 | KEGG: kyoto encyclopedia of genes and genomes. | M Kanehisa, S Goto | Nucleic Acids Res | 2000 | 10592173 | Yes |
127 | 6293 | 6293.0 | 195.21 | 195.2 | The VideoToolbox software for visual psychophysics: transforming numbers into movies. | D G Pelli | Spat Vis | 1997 | 9176953 | Yes |
128 | 12545 | 6272.5 | 0.0 | 0.0 | Statistical aspects of the analysis of data from retrospective studies of disease. | N Mantel, W Haenszel | J Natl Cancer Inst | 1959 | 13655060 | Yes |
129 | 6246 | 6246.0 | 177.75 | 177.8 | Apoptosis: a review of programmed cell death. | Susan Elmore | Toxicol Pathol | 2007 | 17562483 | No |
130 | 6189 | 6189.0 | 206.7 | 206.7 | Ethical guidelines for investigations of experimental pain in conscious animals. | Manfred Zimmermann | Pain | 1983 | 6877845 | No |
131 | 18547 | 6182.3 | 894.28 | 298.1 | Trimmomatic: a flexible trimmer for Illumina sequence data. | Anthony M Bolger, Marc Lohse, Bjoern Usadel | Bioinformatics | 2014 | 24695404 | Yes |
132 | 6156 | 6156.0 | 135.64 | 135.6 | p53, the cellular gatekeeper for growth and division. | A J Levine | Cell | 1997 | 9039259 | No |
133 | 12189 | 6094.5 | 0.0 | 0.0 | A rapid alkaline extraction procedure for screening recombinant plasmid DNA. | H C Birnboim, J Doly | Nucleic Acids Res | 1979 | 388356 | Yes |
134 | 6064 | 6064.0 | 292.0 | 292.0 | Investigation of the freely available easy-to-use software 'EZR' for medical statistics. | Y Kanda | Bone Marrow Transplant | 2013 | 23208313 | Yes |
135 | 6023 | 6023.0 | 150.53 | 150.5 | Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. | T A Springer | Cell | 1994 | 7507411 | No |
136 | 23989 | 5997.2 | 0.0 | 0.0 | Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. | J M Chirgwin, A E Przybyla, R J MacDonald, W J Rutter | Biochemistry | 1979 | 518835 | Yes |
137 | 5951 | 5951.0 | 152.68 | 152.7 | Inositol trisphosphate and calcium signalling. | M J Berridge | Nature | 1993 | 8381210 | No |
138 | 11895 | 5947.5 | 0.0 | 0.0 | Prediction of creatinine clearance from serum creatinine. | D W Cockcroft, M H Gault | Nephron | 1976 | 1244564 | Yes |
139 | 5933 | 5933.0 | 195.23 | 195.2 | The Clinical Dementia Rating (CDR): current version and scoring rules. | J C Morris | Neurology | 1993 | 8232972 | Yes |
140 | 5919 | 5919.0 | 152.48 | 152.5 | G proteins: transducers of receptor-generated signals. | A G Gilman | Annu Rev Biochem | 1987 | 3113327 | No |
141 | 5881 | 5881.0 | 122.48 | 122.5 | Integrins: bidirectional, allosteric signaling machines. | Richard O Hynes | Cell | 2002 | 12297042 | No |
142 | 17623 | 5874.3 | 1369.35 | 456.4 | MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. | Sudhir Kumar, Glen Stecher, Koichiro Tamura | Mol Biol Evol | 2016 | 27004904 | Yes |
143 | 5822 | 5822.0 | 133.82 | 133.8 | Inflammation in atherosclerosis. | Peter Libby | Nature | 2002 | 12490960 | No |
144 | 11565 | 5782.5 | 0.0 | 0.0 | Intraclass correlations: uses in assessing rater reliability. | P E Shrout, J L Fleiss | Psychol Bull | 1979 | 18839484 | No |
145 | 5743 | 5743.0 | 144.6 | 144.6 | Inflammation, atherosclerosis, and coronary artery disease. | Göran K Hansson | N Engl J Med | 2005 | 15843671 | No |
146 | 11432 | 5716.0 | 0.0 | 0.0 | The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. | T Omura, R Sato | J Biol Chem | 1964 | 14209971 | Yes |
147 | 11330 | 5665.0 | 403.21 | 201.6 | The meaning and use of the area under a receiver operating characteristic (ROC) curve. | J A Hanley, B J McNeil | Radiology | 1982 | 7063747 | Yes |
148 | 5640 | 5640.0 | 139.49 | 139.5 | Biochemistry and molecular cell biology of diabetic complications. | M Brownlee | Nature | 2001 | 11742414 | Yes |
149 | 5639 | 5639.0 | 144.72 | 144.7 | Apoptosis in the pathogenesis and treatment of disease. | C B Thompson | Science | 1995 | 7878464 | No |
150 | 5582 | 5582.0 | 0.0 | 0.0 | A Self-Rating Depression Scale. | W W Zung | Arch Gen Psychiatry | 1965 | 14221692 | Yes |
151 | 5556 | 5556.0 | 136.48 | 136.5 | Free radicals in the physiological control of cell function. | Wulf Dröge | Physiol Rev | 2002 | 11773609 | No |
152 | 10947 | 5473.5 | 275.05 | 137.5 | MRBAYES: Bayesian inference of phylogenetic trees. | J P Huelsenbeck, F Ronquist | Bioinformatics | 2001 | 11524383 | Yes |
153 | 10937 | 5468.5 | 252.01 | 126.0 | Dendritic cells and the control of immunity. | J Banchereau, R M Steinman | Nature | 1998 | 9521319 | No |
154 | 10912 | 5456.0 | 295.8 | 147.9 | Sequencing end-labeled DNA with base-specific chemical cleavages. | A M Maxam, W Gilbert | Methods Enzymol | 1980 | 6246368 | Yes |
155 | 10877 | 5438.5 | 0.0 | 0.0 | A series of normal stages in the development of the chick embryo. | V Hamburger, H L Hamilton | J Morphol | 1951 | 24539719 | Yes |
156 | 16301 | 5433.7 | 0.0 | 0.0 | Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. | H Ohkawa, N Ohishi, K Yagi | Anal Biochem | 1979 | 36810 | Yes |
157 | 5422 | 5422.0 | 0.0 | 0.0 | Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. | F Tietze | Anal Biochem | 1969 | 4388022 | Yes |
158 | 5382 | 5382.0 | 195.69 | 195.7 | The Strengths and Difficulties Questionnaire: a research note. | R Goodman | J Child Psychol Psychiatry | 1997 | 9255702 | Yes |
159 | 5374 | 5374.0 | 105.94 | 105.9 | BLAT--the BLAST-like alignment tool. | W James Kent | Genome Res | 2002 | 11932250 | Yes |
160 | 16106 | 5368.7 | 523.11 | 174.4 | Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. | Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien | Ann Surg | 2004 | 15273542 | Yes |
161 | 5348 | 5348.0 | 137.24 | 137.2 | New M13 vectors for cloning. | J Messing | Methods Enzymol | 1983 | 6310323 | Yes |
162 | 5317 | 5317.0 | 129.1 | 129.1 | Antimicrobial peptides of multicellular organisms. | Michael Zasloff | Nature | 2002 | 11807545 | Yes |
163 | 5302 | 5302.0 | 0.0 | 0.0 | Modification of seizure activity by electrical stimulation. II. Motor seizure. | R J Racine | Electroencephalogr Clin Neurophysiol | 1972 | 4110397 | Yes |
164 | 5298 | 5298.0 | 0.0 | 0.0 | Evaluation of survival data and two new rank order statistics arising in its consideration. | N Mantel | Cancer Chemother Rep | 1966 | 5910392 | Yes |
165 | 5273 | 5273.0 | 118.95 | 119.0 | The biochemistry of apoptosis. | M O Hengartner | Nature | 2000 | 11048727 | No |
166 | 5255 | 5255.0 | 153.32 | 153.3 | Studies and perspectives of protein kinase C. | Y Nishizuka | Science | 1986 | 3014651 | No |
167 | 5253 | 5253.0 | 142.5 | 142.5 | The Cambridge Structural Database: a quarter of a million crystal structures and rising. | Frank H Allen | Acta Crystallogr B | 2002 | 12037359 | Yes |
168 | 5243 | 5243.0 | 269.78 | 269.8 | UPARSE: highly accurate OTU sequences from microbial amplicon reads. | Robert C Edgar | Nat Methods | 2013 | 23955772 | Yes |
169 | 10453 | 5226.5 | 247.75 | 123.9 | Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. | W Kabsch, C Sander | Biopolymers | 1983 | 6667333 | Yes |
170 | 15669 | 5223.0 | 475.61 | 158.5 | A simple salting out procedure for extracting DNA from human nucleated cells. | S A Miller, D D Dykes, H F Polesky | Nucleic Acids Res | 1988 | 3344216 | Yes |
171 | 5221 | 5221.0 | 0.0 | 0.0 | [A micro-method of immuno-electrophoresis]. | J J Scheidegger | Int Arch Allergy Appl Immunol | 1955 | 13262900 | Yes |
172 | 10439 | 5219.5 | 300.65 | 150.3 | MODELTEST: testing the model of DNA substitution. | D Posada, K A Crandall | Bioinformatics | 1998 | 9918953 | Yes |
173 | 31268 | 5211.3 | 3600.89 | 600.1 | Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. | Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal | CA Cancer J Clin | 2018 | 30207593 | Yes |
174 | 5177 | 5177.0 | 0.0 | 0.0 | Selective extraction of polyoma DNA from infected mouse cell cultures. | B Hirt | J Mol Biol | 1967 | 4291934 | Yes |
175 | 5165 | 5165.0 | 190.51 | 190.5 | Oxygen-derived free radicals in postischemic tissue injury. | J M McCord | N Engl J Med | 1985 | 2981404 | No |
176 | 15493 | 5164.3 | 459.19 | 153.1 | edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. | Mark D Robinson, Davis J McCarthy, Gordon K Smyth | Bioinformatics | 2010 | 19910308 | Yes |
177 | 10319 | 5159.5 | 251.31 | 125.7 | A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. | Stéphane Guindon, Olivier Gascuel | Syst Biol | 2003 | 14530136 | Yes |
178 | 5148 | 5148.0 | 0.0 | 0.0 | The Environment And Disease: Association Or Causation? | A B Hill | Proc R Soc Med | 1965 | 14283879 | Yes |
179 | 5130 | 5130.0 | 0.0 | 0.0 | Mutation and cancer: statistical study of retinoblastoma. | A G Knudson | Proc Natl Acad Sci U S A | 1971 | 5279523 | Yes |
180 | 5121 | 5121.0 | 126.49 | 126.5 | The NF-kappa B and I kappa B proteins: new discoveries and insights. | A S Baldwin | Annu Rev Immunol | 1996 | 8717528 | No |
181 | 5118 | 5118.0 | 288.44 | 288.4 | Prokka: rapid prokaryotic genome annotation. | Torsten Seemann | Bioinformatics | 2014 | 24642063 | Yes |
182 | 25543 | 5108.6 | 702.62 | 140.5 | The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. | J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G Higgins | Nucleic Acids Res | 1997 | 9396791 | Yes |
183 | 5099 | 5099.0 | 132.29 | 132.3 | Inflammation and metabolic disorders. | Gökhan S Hotamisligil | Nature | 2006 | 17167474 | No |
184 | 5081 | 5081.0 | 120.54 | 120.5 | Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. | J Castresana | Mol Biol Evol | 2000 | 10742046 | Yes |
185 | 5074 | 5074.0 | 0.0 | 0.0 | Aging: a theory based on free radical and radiation chemistry. | D Harman | J Gerontol | 1956 | 13332224 | Yes |
186 | 5066 | 5066.0 | 175.22 | 175.2 | jModelTest: phylogenetic model averaging. | David Posada | Mol Biol Evol | 2008 | 18397919 | Yes |
187 | 10116 | 5058.0 | 374.8 | 187.4 | The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. | R F Furchgott, J V Zawadzki | Nature | 1980 | 6253831 | Yes |
188 | 10090 | 5045.0 | 230.82 | 115.4 | One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. | K A Datsenko, B L Wanner | Proc Natl Acad Sci U S A | 2000 | 10829079 | Yes |
189 | 5042 | 5042.0 | 205.73 | 205.7 | Orienting of attention. | M I Posner | Q J Exp Psychol | 1980 | 7367577 | Yes |
190 | 10051 | 5025.5 | 268.57 | 134.3 | Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. | H Schägger, G von Jagow | Anal Biochem | 1987 | 2449095 | Yes |
191 | 15031 | 5010.3 | 465.98 | 155.3 | The PHQ-9: validity of a brief depression severity measure. | K Kroenke, R L Spitzer, J B Williams | J Gen Intern Med | 2001 | 11556941 | Yes |
192 | 10005 | 5002.5 | 365.41 | 182.7 | Three approaches to qualitative content analysis. | Hsiu-Fang Hsieh, Sarah E Shannon | Qual Health Res | 2005 | 16204405 | Yes |
193 | 5002 | 5002.0 | 0.0 | 0.0 | Development of a rating scale for primary depressive illness. | M Hamilton | Br J Soc Clin Psychol | 1967 | 6080235 | Yes |
194 | 4982 | 4982.0 | 0.0 | 0.0 | A protein binding assay for adenosine 3':5'-cyclic monophosphate. | A G Gilman | Proc Natl Acad Sci U S A | 1970 | 4318781 | Yes |
195 | 4970 | 4970.0 | 184.22 | 184.2 | Analyzing Tables Of Statistical Tests. | William R Rice | Evolution | 1989 | 28568501 | Yes |
196 | 9892 | 4946.0 | 279.94 | 140.0 | Neuropathological stageing of Alzheimer-related changes. | H Braak, E Braak | Acta Neuropathol | 1991 | 1759558 | No |
197 | 4946 | 4946.0 | 102.5 | 102.5 | Rho GTPases and the actin cytoskeleton. | A Hall | Science | 1998 | 9438836 | No |
198 | 14804 | 4934.7 | 540.55 | 180.2 | Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. | S M Hsu, L Raine, H Fanger | J Histochem Cytochem | 1981 | 6166661 | Yes |
199 | 4932 | 4932.0 | 0.0 | 0.0 | Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. | C B Laurell | Anal Biochem | 1966 | 5959431 | Yes |
200 | 9795 | 4897.5 | 357.99 | 179.0 | Ligand: a versatile computerized approach for characterization of ligand-binding systems. | P J Munson, D Rodbard | Anal Biochem | 1980 | 6254391 | Yes |
201 | 4872 | 4872.0 | 99.61 | 99.6 | Epithelial-mesenchymal transitions in tumour progression. | Jean Paul Thiery | Nat Rev Cancer | 2002 | 12189386 | No |
202 | 4847 | 4847.0 | 0.0 | 0.0 | Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. | M Rodbell | J Biol Chem | 1964 | 14169133 | Yes |
203 | 4836 | 4836.0 | 146.61 | 146.6 | Developments of a water-maze procedure for studying spatial learning in the rat. | R Morris | J Neurosci Methods | 1984 | 6471907 | Yes |
204 | 14503 | 4834.3 | 395.59 | 131.9 | Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. | C Yanisch-Perron, J Vieira, J Messing | Gene | 1985 | 2985470 | Yes |
205 | 14475 | 4825.0 | 361.82 | 120.6 | A comprehensive set of sequence analysis programs for the VAX. | J Devereux, P Haeberli, O Smithies | Nucleic Acids Res | 1984 | 6546423 | Yes |
206 | 9626 | 4813.0 | 0.0 | 0.0 | A quantitative description of membrane current and its application to conduction and excitation in nerve. | A L Hodgkin, A F Huxley | J Physiol | 1952 | 12991237 | Yes |
207 | 4798 | 4798.0 | 136.63 | 136.6 | A modified poisson regression approach to prospective studies with binary data. | Guangyong Zou | Am J Epidemiol | 2004 | 15033648 | Yes |
208 | 4787 | 4787.0 | 314.39 | 314.4 | SHELXT - integrated space-group and crystal-structure determination. | George M Sheldrick | Acta Crystallogr A Found Adv | 2015 | 25537383 | Yes |
209 | 4772 | 4772.0 | 97.41 | 97.4 | An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. | M Kozak | Nucleic Acids Res | 1987 | 3313277 | No |
210 | 14291 | 4763.7 | 0.0 | 0.0 | Determination of serum proteins by means of the biuret reaction. | A G Gornall, C J Bardawill, M M David | J Biol Chem | 1949 | 18110453 | Yes |
211 | 4728 | 4728.0 | 0.0 | 0.0 | The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. | P Lauren | Acta Pathol Microbiol Scand | 1965 | 14320675 | Yes |
212 | 9454 | 4727.0 | 0.0 | 0.0 | A new technique for the assay of infectivity of human adenovirus 5 DNA. | F L Graham, A J van der Eb | Virology | 1973 | 4705382 | Yes |
213 | 4712 | 4712.0 | 131.58 | 131.6 | Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. | P Matsudaira | J Biol Chem | 1987 | 3611052 | Yes |
214 | 4706 | 4706.0 | 119.38 | 119.4 | Emotion circuits in the brain. | J E LeDoux | Annu Rev Neurosci | 2000 | 10845062 | No |
215 | 9381 | 4690.5 | 326.47 | 163.2 | AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. | Oleg Trott, Arthur J Olson | J Comput Chem | 2010 | 19499576 | Yes |
216 | 9356 | 4678.0 | 227.44 | 113.7 | Comparative protein modelling by satisfaction of spatial restraints. | A Sali, T L Blundell | J Mol Biol | 1993 | 8254673 | Yes |
217 | 9321 | 4660.5 | 237.5 | 118.8 | Improved tools for biological sequence comparison. | W R Pearson, D J Lipman | Proc Natl Acad Sci U S A | 1988 | 3162770 | Yes |
218 | 9318 | 4659.0 | 271.35 | 135.7 | EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. | Arnaud Delorme, Scott Makeig | J Neurosci Methods | 2004 | 15102499 | Yes |
219 | 4658 | 4658.0 | 106.97 | 107.0 | ras oncogenes in human cancer: a review. | J L Bos | Cancer Res | 1989 | 2547513 | No |
220 | 4658 | 4658.0 | 158.56 | 158.6 | The pathogenesis of atherosclerosis--an update. | R Ross | N Engl J Med | 1986 | 3511384 | No |
221 | 9314 | 4657.0 | 229.27 | 114.6 | A genetic model for colorectal tumorigenesis. | E R Fearon, B Vogelstein | Cell | 1990 | 2188735 | No |
222 | 9292 | 4646.0 | 245.75 | 122.9 | BEDTools: a flexible suite of utilities for comparing genomic features. | Aaron R Quinlan, Ira M Hall | Bioinformatics | 2010 | 20110278 | Yes |
223 | 4621 | 4621.0 | 104.19 | 104.2 | Cancer cell cycles. | C J Sherr | Science | 1996 | 8939849 | No |
224 | 9240 | 4620.0 | 0.0 | 0.0 | A new depression scale designed to be sensitive to change. | S A Montgomery, M Asberg | Br J Psychiatry | 1979 | 444788 | Yes |
225 | 13846 | 4615.3 | 486.54 | 162.2 | Nitric oxide: physiology, pathophysiology, and pharmacology. | S Moncada, R M Palmer, E A Higgs | Pharmacol Rev | 1991 | 1852778 | No |
226 | 9222 | 4611.0 | 206.25 | 103.1 | Inflammation and cancer. | Lisa M Coussens, Zena Werb | Nature | 2002 | 12490959 | No |
227 | 4597 | 4597.0 | 0.0 | 0.0 | Aggregation of blood platelets by adenosine diphosphate and its reversal. | G V Born | Nature | 1962 | 13871375 | Yes |
228 | 18334 | 4583.5 | 570.05 | 142.5 | MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. | Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir Kumar | Mol Biol Evol | 2007 | 17488738 | Yes |
229 | 4582 | 4582.0 | 0.0 | 0.0 | A rapid banding technique for human chromosomes. | M Seabright | Lancet | 1971 | 4107917 | Yes |
230 | 9144 | 4572.0 | 209.1 | 104.5 | The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. | John Hardy, Dennis J Selkoe | Science | 2002 | 12130773 | No |
231 | 13715 | 4571.7 | 528.24 | 176.1 | The positive and negative syndrome scale (PANSS) for schizophrenia. | S R Kay, A Fiszbein, L A Opler | Schizophr Bull | 1987 | 3616518 | Yes |
232 | 18245 | 4561.2 | 643.67 | 160.9 | G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. | Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner | Behav Res Methods | 2007 | 17695343 | Yes |
233 | 4547 | 4547.0 | 0.0 | 0.0 | The clonal evolution of tumor cell populations. | P C Nowell | Science | 1976 | 959840 | Yes |
234 | 4534 | 4534.0 | 137.4 | 137.4 | A fast diffeomorphic image registration algorithm. | John Ashburner | Neuroimage | 2007 | 17761438 | Yes |
235 | 4489 | 4489.0 | 96.25 | 96.2 | Targeting HIF-1 for cancer therapy. | Gregg L Semenza | Nat Rev Cancer | 2003 | 13130303 | No |
236 | 4477 | 4477.0 | 0.0 | 0.0 | Index for rating diagnostic tests. | W J Youden | Cancer | 1950 | 15405679 | Yes |
237 | 13423 | 4474.3 | 302.21 | 100.7 | Refinement of macromolecular structures by the maximum-likelihood method. | G N Murshudov, A A Vagin, E J Dodson | Acta Crystallogr D Biol Crystallogr | 1997 | 15299926 | Yes |
238 | 8936 | 4468.0 | 0.0 | 0.0 | Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). | J M McCord, I Fridovich | J Biol Chem | 1969 | 5389100 | Yes |
239 | 4465 | 4465.0 | 98.05 | 98.0 | ras genes. | M Barbacid | Annu Rev Biochem | 1987 | 3304147 | No |
240 | 4459 | 4459.0 | 104.44 | 104.4 | MUSCLE: a multiple sequence alignment method with reduced time and space complexity. | Robert C Edgar | BMC Bioinformatics | 2004 | 15318951 | Yes |
241 | 4457 | 4457.0 | 109.59 | 109.6 | A new method for predicting signal sequence cleavage sites. | G von Heijne | Nucleic Acids Res | 1986 | 3714490 | Yes |
242 | 4442 | 4442.0 | 0.0 | 0.0 | The McGill Pain Questionnaire: major properties and scoring methods. | Ronald Melzack | Pain | 1975 | 1235985 | Yes |
243 | 8884 | 4442.0 | 0.0 | 0.0 | A simplified method of evaluating dose-effect experiments. | J T Litchfield, F Wilcoxon | J Pharmacol Exp Ther | 1949 | 18152921 | Yes |
244 | 22164 | 4432.8 | 1154.19 | 230.8 | MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. | Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir Kumar | Mol Biol Evol | 2013 | 24132122 | Yes |
245 | 22123 | 4424.6 | 0.0 | 0.0 | An inventory for measuring depression. | A T Beck, C H Ward, M Mendelson, J Mock, J Erbaugh | Arch Gen Psychiatry | 1961 | 13688369 | Yes |
246 | 13236 | 4412.0 | 337.5 | 112.5 | Inference of population structure using multilocus genotype data. | J K Pritchard, M Stephens, P Donnelly | Genetics | 2000 | 10835412 | Yes |
247 | 4400 | 4400.0 | 101.54 | 101.5 | Alzheimer's disease: genes, proteins, and therapy. | D J Selkoe | Physiol Rev | 2001 | 11274343 | No |
248 | 8786 | 4393.0 | 0.0 | 0.0 | A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. | W M Bonner, R A Laskey | Eur J Biochem | 1974 | 4850204 | Yes |
249 | 4381 | 4381.0 | 86.16 | 86.2 | DNA methylation patterns and epigenetic memory. | Adrian Bird | Genes Dev | 2002 | 11782440 | No |
250 | 4363 | 4363.0 | 89.84 | 89.8 | Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. | M Kozak | Cell | 1986 | 3943125 | Yes |
251 | 8725 | 4362.5 | 200.47 | 100.2 | Primer3 on the WWW for general users and for biologist programmers. | S Rozen, H Skaletsky | Methods Mol Biol | 2000 | 10547847 | Yes |
252 | 4353 | 4353.0 | 0.0 | 0.0 | Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. | W H Harris | J Bone Joint Surg Am | 1969 | 5783851 | Yes |
253 | 8703 | 4351.5 | 294.77 | 147.4 | Operating characteristics of a rank correlation test for publication bias. | C B Begg, M Mazumdar | Biometrics | 1994 | 7786990 | Yes |
254 | 4344 | 4344.0 | 0.0 | 0.0 | Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. | M M Mesulam | J Histochem Cytochem | 1978 | 24068 | Yes |
255 | 4340 | 4340.0 | 100.38 | 100.4 | Prions. | S B Prusiner | Proc Natl Acad Sci U S A | 1998 | 9811807 | No |
256 | 4331 | 4331.0 | 121.94 | 121.9 | Mild cognitive impairment as a diagnostic entity. | R C Petersen | J Intern Med | 2004 | 15324362 | No |
257 | 4316 | 4316.0 | 0.0 | 0.0 | The Limited In Vitro Lifetime Of Human Diploid Cell Strains. | L Hayflick | Exp Cell Res | 1965 | 14315085 | Yes |
258 | 4303 | 4303.0 | 112.96 | 113.0 | Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. | Y Nishizuka | Science | 1992 | 1411571 | No |
259 | 8593 | 4296.5 | 0.0 | 0.0 | Preparation of iodine-131 labelled human growth hormone of high specific activity. | W M Hunter, F C Greenwood | Nature | 1962 | 14450081 | Yes |
260 | 4280 | 4280.0 | 170.54 | 170.5 | Revisiting the behavioral model and access to medical care: does it matter? | R M Andersen | J Health Soc Behav | 1995 | 7738325 | Yes |
261 | 8559 | 4279.5 | 0.0 | 0.0 | Parkinsonism: onset, progression and mortality. | M M Hoehn, M D Yahr | Neurology | 1967 | 6067254 | Yes |
262 | 8545 | 4272.5 | 243.87 | 121.9 | Differential expression analysis for sequence count data. | Simon Anders, Wolfgang Huber | Genome Biol | 2010 | 20979621 | Yes |
263 | 4258 | 4258.0 | 113.68 | 113.7 | The molecular heterogeneity of protein kinase C and its implications for cellular regulation. | Y Nishizuka | Nature | 1988 | 3045562 | No |
264 | 25432 | 4238.7 | 1011.44 | 168.6 | Global cancer statistics. | Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David Forman | CA Cancer J Clin | 2011 | 21296855 | Yes |
265 | 4231 | 4231.0 | 100.7 | 100.7 | Cancer. p53, guardian of the genome. | D P Lane | Nature | 1992 | 1614522 | No |
266 | 4227 | 4227.0 | 94.38 | 94.4 | Apoptosis by death factor. | S Nagata | Cell | 1997 | 9039262 | No |
267 | 8444 | 4222.0 | 230.68 | 115.3 | A synaptic model of memory: long-term potentiation in the hippocampus. | T V Bliss, G L Collingridge | Nature | 1993 | 8421494 | No |
268 | 4220 | 4220.0 | 113.17 | 113.2 | Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. | A H Wyllie | Nature | 1980 | 6245367 | Yes |
269 | 4211 | 4211.0 | 0.0 | 0.0 | The need for a new medical model: a challenge for biomedicine. | G L Engel | Science | 1977 | 847460 | Yes |
270 | 4209 | 4209.0 | 94.87 | 94.9 | Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. | S Henikoff | Gene | 1984 | 6235151 | Yes |
271 | 4207 | 4207.0 | 0.0 | 0.0 | Amino acid metabolism in mammalian cell cultures. | H Eagle | Science | 1959 | 13675766 | Yes |
272 | 8393 | 4196.5 | 248.49 | 124.2 | The rise of graphene. | A K Geim, K S Novoselov | Nat Mater | 2007 | 17330084 | Yes |
273 | 4190 | 4190.0 | 0.0 | 0.0 | A relation between non-esterified fatty acids in plasma and the metabolism of glucose. | V P Dole | J Clin Invest | 1956 | 13286333 | Yes |
274 | 4182 | 4182.0 | 0.0 | 0.0 | The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. | T Nash | Biochem J | 1953 | 13105648 | Yes |
275 | 4181 | 4181.0 | 0.0 | 0.0 | Estimation of nuclear population from microtome sections. | M Abercrombie | Anat Rec | 1946 | 21015608 | Yes |
276 | 8333 | 4166.5 | 0.0 | 0.0 | Assessment of coma and impaired consciousness. A practical scale. | G Teasdale, B Jennett | Lancet | 1974 | 4136544 | Yes |
277 | 4163 | 4163.0 | 0.0 | 0.0 | The genetical evolution of social behaviour. I. | W D Hamilton | J Theor Biol | 1964 | 5875341 | Yes |
278 | 16600 | 4150.0 | 0.0 | 0.0 | A new and rapid colorimetric determination of acetylcholinesterase activity. | G L Ellman, K D Courtney, V Andres, R M Feather-Stone | Biochem Pharmacol | 1961 | 13726518 | Yes |
279 | 8284 | 4142.0 | 196.23 | 98.1 | SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. | N Guex, M C Peitsch | Electrophoresis | 1997 | 9504803 | Yes |
280 | 8245 | 4122.5 | 179.4 | 89.7 | Genomic sequencing. | G M Church, W Gilbert | Proc Natl Acad Sci U S A | 1984 | 6326095 | Yes |
281 | 24727 | 4121.2 | 1037.51 | 172.9 | MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. | Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir Kumar | Mol Biol Evol | 2011 | 21546353 | Yes |
282 | 4121 | 4121.0 | 99.14 | 99.1 | Mechanisms of angiogenesis. | W Risau | Nature | 1997 | 9109485 | No |
283 | 4109 | 4109.0 | 89.33 | 89.3 | Alternative activation of macrophages. | Siamon Gordon | Nat Rev Immunol | 2003 | 12511873 | No |
284 | 4107 | 4107.0 | 87.44 | 87.4 | The retinoblastoma protein and cell cycle control. | R A Weinberg | Cell | 1995 | 7736585 | No |
285 | 4101 | 4101.0 | 125.42 | 125.4 | Glutamate neurotoxicity and diseases of the nervous system. | D W Choi | Neuron | 1988 | 2908446 | No |
286 | 4089 | 4089.0 | 87.28 | 87.3 | Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. | C J Marshall | Cell | 1995 | 7834738 | No |
287 | 4084 | 4084.0 | 0.0 | 0.0 | The determination of enzyme inhibitor constants. | M Dixon | Biochem J | 1953 | 13093635 | Yes |
288 | 4076 | 4076.0 | 165.32 | 165.3 | An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. | Peter C Austin | Multivariate Behav Res | 2011 | 21818162 | Yes |
289 | 4066 | 4066.0 | 0.0 | 0.0 | Determination of protein: a modification of the Lowry method that gives a linear photometric response. | E F Hartree | Anal Biochem | 1972 | 4115981 | Yes |
290 | 4043 | 4043.0 | 123.01 | 123.0 | How mitochondria produce reactive oxygen species. | Michael P Murphy | Biochem J | 2009 | 19061483 | No |
291 | 4042 | 4042.0 | 80.6 | 80.6 | The phosphoinositide 3-kinase pathway. | Lewis C Cantley | Science | 2002 | 12040186 | No |
292 | 4033 | 4033.0 | 75.43 | 75.4 | Generalized lacZ expression with the ROSA26 Cre reporter strain. | P Soriano | Nat Genet | 1999 | 9916792 | Yes |
293 | 3997 | 3997.0 | 0.0 | 0.0 | Bone: formation by autoinduction. | M R Urist | Science | 1965 | 5319761 | Yes |
294 | 3988 | 3988.0 | 0.0 | 0.0 | Staining of tissue sections for electron microscopy with heavy metals. | M L Watson | J Biophys Biochem Cytol | 1958 | 13563554 | Yes |
295 | 3977 | 3977.0 | 126.55 | 126.5 | Bacterial evolution. | C R Woese | Microbiol Rev | 1987 | 2439888 | No |
296 | 3975 | 3975.0 | 87.52 | 87.5 | Wnt/beta-catenin signaling in development and disease. | Hans Clevers | Cell | 2006 | 17081971 | No |
297 | 3954 | 3954.0 | 103.66 | 103.7 | Integrins: a family of cell surface receptors. | R O Hynes | Cell | 1987 | 3028640 | No |
298 | 3938 | 3938.0 | 0.0 | 0.0 | The detection of disease clustering and a generalized regression approach. | N Mantel | Cancer Res | 1967 | 6018555 | Yes |
299 | 3930 | 3930.0 | 0.0 | 0.0 | Disc Electrophoresis. I. Background And Theory. | L Ornstein | Ann N Y Acad Sci | 1964 | 14240533 | Yes |
300 | 7849 | 3924.5 | 0.0 | 0.0 | Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. | H Aviv, P Leder | Proc Natl Acad Sci U S A | 1972 | 4504350 | Yes |
301 | 7845 | 3922.5 | 0.0 | 0.0 | Functional Evaluation: The Barthel Index. | F I Mahoney, D W Barthel | Md State Med J | 1965 | 14258950 | Yes |
302 | 3911 | 3911.0 | 129.05 | 129.1 | Tissue destruction by neutrophils. | S J Weiss | N Engl J Med | 1989 | 2536474 | No |
303 | 11717 | 3905.7 | 802.03 | 267.3 | Cancer statistics, 2016. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2016 | 26742998 | Yes |
304 | 7781 | 3890.5 | 0.0 | 0.0 | Assessment of older people: self-maintaining and instrumental activities of daily living. | M P Lawton, E M Brody | Gerontologist | 1969 | 5349366 | Yes |
305 | 3875 | 3875.0 | 120.82 | 120.8 | Nitric oxide as a secretory product of mammalian cells. | C Nathan | FASEB J | 1992 | 1381691 | No |
306 | 3870 | 3870.0 | 107.27 | 107.3 | What is the evidence that tumors are angiogenesis dependent? | J Folkman | J Natl Cancer Inst | 1990 | 1688381 | No |
307 | 3865 | 3865.0 | 0.0 | 0.0 | Pharmacological implications of microsomal enzyme induction. | A H Conney | Pharmacol Rev | 1967 | 4383307 | Yes |
308 | 7691 | 3845.5 | 184.34 | 92.2 | MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. | Jürgen Cox, Matthias Mann | Nat Biotechnol | 2008 | 19029910 | Yes |
309 | 3844 | 3844.0 | 87.64 | 87.6 | PAML: a program package for phylogenetic analysis by maximum likelihood. | Z Yang | Comput Appl Biosci | 1997 | 9367129 | Yes |
310 | 7669 | 3834.5 | 219.15 | 109.6 | Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. | Florian Weigend, Reinhart Ahlrichs | Phys Chem Chem Phys | 2005 | 16240044 | Yes |
311 | 7649 | 3824.5 | 188.75 | 94.4 | Collective dynamics of 'small-world' networks. | D J Watts, S H Strogatz | Nature | 1998 | 9623998 | Yes |
312 | 7637 | 3818.5 | 0.0 | 0.0 | Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. | D E Paglia, W N Valentine | J Lab Clin Med | 1967 | 6066618 | Yes |
313 | 3811 | 3811.0 | 85.86 | 85.9 | Atherosclerosis. | A J Lusis | Nature | 2000 | 11001066 | No |
314 | 3808 | 3808.0 | 0.0 | 0.0 | New methods for calculating metabolic rate with special reference to protein metabolism. | J B De B Weir | J Physiol | 1949 | 15394301 | Yes |
315 | 11375 | 3791.7 | 0.0 | 0.0 | Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. | W H Habig, M J Pabst, W B Jakoby | J Biol Chem | 1974 | 4436300 | Yes |
316 | 3791 | 3791.0 | 141.86 | 141.9 | EuroQol: the current state of play. | R Brooks | Health Policy | 1996 | 10158943 | No |
317 | 3791 | 3791.0 | 133.16 | 133.2 | Whatever happened to qualitative description? | M Sandelowski | Res Nurs Health | 2000 | 10940958 | No |
318 | 3783 | 3783.0 | 127.31 | 127.3 | Updating P300: an integrative theory of P3a and P3b. | John Polich | Clin Neurophysiol | 2007 | 17573239 | No |
319 | 7559 | 3779.5 | 238.92 | 119.5 | RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. | Bo Li, Colin N Dewey | BMC Bioinformatics | 2011 | 21816040 | Yes |
320 | 3775 | 3775.0 | 80.77 | 80.8 | A catalogue of splice junction sequences. | S M Mount | Nucleic Acids Res | 1982 | 7063411 | Yes |
321 | 7548 | 3774.0 | 223.32 | 111.7 | Estimating F-Statistics For The Analysis Of Population Structure. | B S Weir, C Clark Cockerham | Evolution | 1984 | 28563791 | Yes |
322 | 3765 | 3765.0 | 104.61 | 104.6 | Revisions in the International System for Staging Lung Cancer. | C F Mountain | Chest | 1997 | 9187198 | Yes |
323 | 3763 | 3763.0 | 81.57 | 81.6 | The green fluorescent protein. | R Y Tsien | Annu Rev Biochem | 1998 | 9759496 | No |
324 | 3759 | 3759.0 | 87.17 | 87.2 | Tandem repeats finder: a program to analyze DNA sequences. | G Benson | Nucleic Acids Res | 1999 | 9862982 | Yes |
325 | 3757 | 3757.0 | 0.0 | 0.0 | Estimation of the molecular weights of proteins by Sephadex gel-filtration. | P Andrews | Biochem J | 1964 | 4158310 | Yes |
326 | 3748 | 3748.0 | 0.0 | 0.0 | Preparation of isolated rat liver cells. | P O Seglen | Methods Cell Biol | 1976 | 177845 | No |
327 | 22458 | 3743.0 | 752.81 | 125.5 | Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. | D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C Turner | Diabetologia | 1985 | 3899825 | Yes |
328 | 3734 | 3734.0 | 108.17 | 108.2 | Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. | J H Morrissey | Anal Biochem | 1981 | 6172996 | Yes |
329 | 11193 | 3731.0 | 503.07 | 167.7 | Development and validation of brief measures of positive and negative affect: the PANAS scales. | D Watson, L A Clark, A Tellegen | J Pers Soc Psychol | 1988 | 3397865 | Yes |
330 | 7460 | 3730.0 | 142.32 | 71.2 | A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. | R S Sikorski, P Hieter | Genetics | 1989 | 2659436 | Yes |
331 | 11137 | 3712.3 | 216.37 | 72.1 | Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. | J D Dignam, R M Lebovitz, R G Roeder | Nucleic Acids Res | 1983 | 6828386 | Yes |
332 | 3709 | 3709.0 | 0.0 | 0.0 | A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. | E Pfeiffer | J Am Geriatr Soc | 1975 | 1159263 | Yes |
333 | 11119 | 3706.3 | 0.0 | 0.0 | Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. | J F Kerr, A H Wyllie, A R Currie | Br J Cancer | 1972 | 4561027 | No |
334 | 3703 | 3703.0 | 0.0 | 0.0 | A membrane-filter technique for the detection of complementary DNA. | D T Denhardt | Biochem Biophys Res Commun | 1966 | 5963888 | Yes |
335 | 3701 | 3701.0 | 100.27 | 100.3 | Staphylococcus aureus infections. | F D Lowy | N Engl J Med | 1998 | 9709046 | No |
336 | 3683 | 3683.0 | 91.58 | 91.6 | Multiple sequence alignment with hierarchical clustering. | F Corpet | Nucleic Acids Res | 1988 | 2849754 | Yes |
337 | 3679 | 3679.0 | 92.81 | 92.8 | Why most published research findings are false. | John P A Ioannidis | PLoS Med | 2005 | 16060722 | Yes |
338 | 7347 | 3673.5 | 293.37 | 146.7 | Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. | Kristopher J Preacher, Andrew F Hayes | Behav Res Methods | 2008 | 18697684 | Yes |
339 | 14682 | 3670.5 | 427.01 | 106.8 | Features and development of Coot. | P Emsley, B Lohkamp, W G Scott, K Cowtan | Acta Crystallogr D Biol Crystallogr | 2010 | 20383002 | Yes |
340 | 3667 | 3667.0 | 89.86 | 89.9 | Caspases: the executioners of apoptosis. | G M Cohen | Biochem J | 1997 | 9337844 | No |
341 | 7315 | 3657.5 | 182.9 | 91.5 | Mitochondria and apoptosis. | D R Green, J C Reed | Science | 1998 | 9721092 | No |
342 | 3651 | 3651.0 | 88.61 | 88.6 | Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. | A T Brünger | Nature | 1992 | 18481394 | Yes |
343 | 3650 | 3650.0 | 77.99 | 78.0 | TGF-beta signal transduction. | J Massagué | Annu Rev Biochem | 1998 | 9759503 | No |
344 | 3637 | 3637.0 | 0.0 | 0.0 | Principles that govern the folding of protein chains. | C B Anfinsen | Science | 1973 | 4124164 | Yes |
345 | 3634 | 3634.0 | 0.0 | 0.0 | Evolution in Mendelian Populations. | S Wright | Genetics | 1931 | 17246615 | Yes |
346 | 14517 | 3629.2 | 398.73 | 99.7 | Global cancer statistics, 2002. | D Max Parkin, Freddie Bray, J Ferlay, Paola Pisani | CA Cancer J Clin | 2005 | 15761078 | Yes |
347 | 7233 | 3616.5 | 0.0 | 0.0 | The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. | R C Graham, M J Karnovsky | J Histochem Cytochem | 1966 | 5962951 | Yes |
348 | 7197 | 3598.5 | 2278.29 | 1139.1 | Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. | Zunyou Wu, Jennifer M McGoogan | JAMA | 2020 | 32091533 | Yes |
349 | 3598 | 3598.0 | 109.66 | 109.7 | Inositol trisphosphate and diacylglycerol as second messengers. | M J Berridge | Biochem J | 1984 | 6146314 | No |
350 | 10785 | 3595.0 | 852.8 | 284.3 | Cancer Statistics, 2017. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2017 | 28055103 | Yes |
351 | 3593 | 3593.0 | 74.87 | 74.9 | Hypoxia--a key regulatory factor in tumour growth. | Adrian L Harris | Nat Rev Cancer | 2002 | 11902584 | No |
352 | 7176 | 3588.0 | 252.34 | 126.2 | DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. | P Librado, J Rozas | Bioinformatics | 2009 | 19346325 | Yes |
353 | 3570 | 3570.0 | 76.37 | 76.4 | Protein secondary structure prediction based on position-specific scoring matrices. | D T Jones | J Mol Biol | 1999 | 10493868 | Yes |
354 | 3562 | 3562.0 | 66.25 | 66.2 | Somatic generation of antibody diversity. | S Tonegawa | Nature | 1983 | 6300689 | No |
355 | 7118 | 3559.0 | 260.88 | 130.4 | Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. | U H Graneheim, B Lundman | Nurse Educ Today | 2004 | 14769454 | No |
356 | 3553 | 3553.0 | 0.0 | 0.0 | Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. | J Cohen | Psychol Bull | 1968 | 19673146 | Yes |
357 | 3544 | 3544.0 | 81.28 | 81.3 | Protein production by auto-induction in high density shaking cultures. | F William Studier | Protein Expr Purif | 2005 | 15915565 | Yes |
358 | 3543 | 3543.0 | 83.23 | 83.2 | Novel proteinaceous infectious particles cause scrapie. | S B Prusiner | Science | 1982 | 6801762 | Yes |
359 | 3543 | 3543.0 | 71.21 | 71.2 | Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. | G R Martin | Proc Natl Acad Sci U S A | 1981 | 6950406 | Yes |
360 | 3540 | 3540.0 | 136.23 | 136.2 | Measuring the accuracy of diagnostic systems. | J A Swets | Science | 1988 | 3287615 | No |
361 | 3537 | 3537.0 | 99.96 | 100.0 | Biological roles of oligosaccharides: all of the theories are correct. | A Varki | Glycobiology | 1993 | 8490246 | No |
362 | 3532 | 3532.0 | 101.39 | 101.4 | Sequencing technologies - the next generation. | Michael L Metzker | Nat Rev Genet | 2010 | 19997069 | No |
363 | 3531 | 3531.0 | 98.96 | 99.0 | Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. | R B D'Agostino | Stat Med | 1998 | 9802183 | Yes |
364 | 7062 | 3531.0 | 0.0 | 0.0 | Radiological assessment of osteo-arthrosis. | J H Kellgren, J S Lawrence | Ann Rheum Dis | 1957 | 13498604 | Yes |
365 | 3519 | 3519.0 | 119.98 | 120.0 | Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. | Russell A Barkley | Psychol Bull | 1997 | 9000892 | No |
366 | 10546 | 3515.3 | 405.44 | 135.1 | A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. | J Ware, M Kosinski, S D Keller | Med Care | 1996 | 8628042 | Yes |
367 | 6999 | 3499.5 | 202.33 | 101.2 | Ab initio molecular dynamics for liquid metals. | Kresse, Hafner | Phys Rev B Condens Matter | 1993 | 10004490 | Yes |
368 | 3496 | 3496.0 | 0.0 | 0.0 | The Scree Test For The Number Of Factors. | R B Cattell | Multivariate Behav Res | 1966 | 26828106 | Yes |
369 | 3494 | 3494.0 | 84.61 | 84.6 | Marrow stromal cells as stem cells for nonhematopoietic tissues. | D J Prockop | Science | 1997 | 9082988 | No |
370 | 6987 | 3493.5 | 181.05 | 90.5 | tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. | T M Lowe, S R Eddy | Nucleic Acids Res | 1997 | 9023104 | Yes |
371 | 3485 | 3485.0 | 0.0 | 0.0 | Statistical estimations in enzyme kinetics. | G N Wilkinson | Biochem J | 1961 | 13785321 | Yes |
372 | 6968 | 3484.0 | 132.14 | 66.1 | Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. | A H Brand, N Perrimon | Development | 1993 | 8223268 | Yes |
373 | 3482 | 3482.0 | 105.38 | 105.4 | Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. | Vanderbilt | Phys Rev B Condens Matter | 1990 | 9993096 | Yes |
374 | 3481 | 3481.0 | 81.74 | 81.7 | Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. | Rakesh K Jain | Science | 2005 | 15637262 | No |
375 | 6952 | 3476.0 | 0.0 | 0.0 | A new method for sequencing DNA. | A M Maxam, W Gilbert | Proc Natl Acad Sci U S A | 1977 | 265521 | Yes |
376 | 3471 | 3471.0 | 115.59 | 115.6 | Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. | Ilan H Meyer | Psychol Bull | 2003 | 12956539 | No |
377 | 6937 | 3468.5 | 157.07 | 78.5 | Functional rafts in cell membranes. | K Simons, E Ikonen | Nature | 1997 | 9177342 | No |
378 | 3468 | 3468.0 | 79.27 | 79.3 | Instability and decay of the primary structure of DNA. | T Lindahl | Nature | 1993 | 8469282 | No |
379 | 17334 | 3466.8 | 504.58 | 100.9 | Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. | O P Hamill, A Marty, E Neher, B Sakmann, F J Sigworth | Pflugers Arch | 1981 | 6270629 | Yes |
380 | 10397 | 3465.7 | 1075.39 | 358.5 | Cancer statistics, 2018. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2018 | 29313949 | Yes |
381 | 3463 | 3463.0 | 0.0 | 0.0 | Spectroscopic determination of tryptophan and tyrosine in proteins. | H Edelhoch | Biochemistry | 1967 | 6049437 | Yes |
382 | 6917 | 3458.5 | 296.0 | 148.0 | The timed "Up & Go": a test of basic functional mobility for frail elderly persons. | D Podsiadlo, S Richardson | J Am Geriatr Soc | 1991 | 1991946 | Yes |
383 | 3442 | 3442.0 | 0.0 | 0.0 | Generalized expectancies for internal versus external control of reinforcement. | J B Rotter | Psychol Monogr | 1966 | 5340840 | No |
384 | 6880 | 3440.0 | 164.72 | 82.4 | "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. | A P Feinberg, B Vogelstein | Anal Biochem | 1984 | 6329026 | Yes |
385 | 3434 | 3434.0 | 0.0 | 0.0 | Basic principles of ROC analysis. | C E Metz | Semin Nucl Med | 1978 | 112681 | Yes |
386 | 3415 | 3415.0 | 71.13 | 71.1 | Mammalian neural stem cells. | F H Gage | Science | 2000 | 10688783 | No |
387 | 6807 | 3403.5 | 207.01 | 103.5 | BEAST: Bayesian evolutionary analysis by sampling trees. | Alexei J Drummond, Andrew Rambaut | BMC Evol Biol | 2007 | 17996036 | Yes |
388 | 10184 | 3394.7 | 1524.65 | 508.2 | Cancer statistics, 2019. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2019 | 30620402 | Yes |
389 | 3387 | 3387.0 | 0.0 | 0.0 | The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. | J F Woessner | Arch Biochem Biophys | 1961 | 13786180 | Yes |
390 | 6768 | 3384.0 | 180.32 | 90.2 | Control of goal-directed and stimulus-driven attention in the brain. | Maurizio Corbetta, Gordon L Shulman | Nat Rev Neurosci | 2002 | 11994752 | No |
391 | 10132 | 3377.3 | 0.0 | 0.0 | The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. | F C Greenwood, W M Hunter, J S Glover | Biochem J | 1963 | 14097352 | Yes |
392 | 3374 | 3374.0 | 77.66 | 77.7 | Scaling and assessment of data quality. | Philip Evans | Acta Crystallogr D Biol Crystallogr | 2006 | 16369096 | No |
393 | 3363 | 3363.0 | 101.26 | 101.3 | What's wrong with Bonferroni adjustments. | T V Perneger | BMJ | 1998 | 9553006 | No |
394 | 3357 | 3357.0 | 103.23 | 103.2 | Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. | L R Squire | Psychol Rev | 1992 | 1594723 | No |
395 | 3355 | 3355.0 | 84.04 | 84.0 | The heat-shock response. | S Lindquist | Annu Rev Biochem | 1986 | 2427013 | No |
396 | 6702 | 3351.0 | 256.08 | 128.0 | The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. | I F Benzie, J J Strain | Anal Biochem | 1996 | 8660627 | Yes |
397 | 6692 | 3346.0 | 173.98 | 87.0 | TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. | T R Mosmann, R L Coffman | Annu Rev Immunol | 1989 | 2523712 | No |
398 | 3345 | 3345.0 | 88.97 | 89.0 | Microglia: a sensor for pathological events in the CNS. | G W Kreutzberg | Trends Neurosci | 1996 | 8843599 | No |
399 | 3339 | 3339.0 | 117.37 | 117.4 | How do you feel--now? The anterior insula and human awareness. | A D Bud Craig | Nat Rev Neurosci | 2009 | 19096369 | No |
400 | 3336 | 3336.0 | 79.26 | 79.3 | The dendritic cell system and its role in immunogenicity. | R M Steinman | Annu Rev Immunol | 1991 | 1910679 | No |
401 | 10007 | 3335.7 | 456.13 | 152.0 | Cancer statistics, 2013. | Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal | CA Cancer J Clin | 2013 | 23335087 | Yes |
402 | 3334 | 3334.0 | 114.81 | 114.8 | genepop'007: a complete re-implementation of the genepop software for Windows and Linux. | François Rousset | Mol Ecol Resour | 2008 | 21585727 | Yes |
403 | 3333 | 3333.0 | 100.78 | 100.8 | Protective and damaging effects of stress mediators. | B S McEwen | N Engl J Med | 1998 | 9428819 | No |
404 | 3330 | 3330.0 | 0.0 | 0.0 | Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. | J D Rowley | Nature | 1973 | 4126434 | Yes |
405 | 3327 | 3327.0 | 69.13 | 69.1 | Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. | M Kozak | Nucleic Acids Res | 1984 | 6694911 | Yes |
406 | 3322 | 3322.0 | 0.0 | 0.0 | Observational study of behavior: sampling methods. | J Altmann | Behaviour | 1974 | 4597405 | No |
407 | 3316 | 3316.0 | 65.41 | 65.4 | Signal transduction by the JNK group of MAP kinases. | R J Davis | Cell | 2000 | 11057897 | No |
408 | 3313 | 3313.0 | 69.1 | 69.1 | The scanning model for translation: an update. | M Kozak | J Cell Biol | 1989 | 2645293 | No |
409 | 3313 | 3313.0 | 0.0 | 0.0 | Equilibrium Ultracentrifugation Of Dilute Solutions. | D A Yphantis | Biochemistry | 1964 | 14155091 | Yes |
410 | 3312 | 3312.0 | 130.5 | 130.5 | A concordance correlation coefficient to evaluate reproducibility. | L I Lin | Biometrics | 1989 | 2720055 | Yes |
411 | 6622 | 3311.0 | 167.46 | 83.7 | WGCNA: an R package for weighted correlation network analysis. | Peter Langfelder, Steve Horvath | BMC Bioinformatics | 2008 | 19114008 | Yes |
412 | 3304 | 3304.0 | 92.41 | 92.4 | Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. | R W Mahley | Science | 1988 | 3283935 | No |
413 | 3303 | 3303.0 | 84.8 | 84.8 | Gene regulation by steroid hormones. | M Beato | Cell | 1989 | 2644044 | No |
414 | 13205 | 3301.2 | 554.95 | 138.7 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | Ann Intern Med | 2009 | 19622511 | No |
415 | 3290 | 3290.0 | 0.0 | 0.0 | Some factors in the interpretation of protein denaturation. | W Kauzmann | Adv Protein Chem | 1959 | 14404936 | Yes |
416 | 6573 | 3286.5 | 124.84 | 62.4 | Translating the histone code. | T Jenuwein, C D Allis | Science | 2001 | 11498575 | No |
417 | 9852 | 3284.0 | 413.7 | 137.9 | Cancer statistics, 2012. | Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal | CA Cancer J Clin | 2012 | 22237781 | Yes |
418 | 3278 | 3278.0 | 89.77 | 89.8 | Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? | Kim A Brogden | Nat Rev Microbiol | 2005 | 15703760 | No |
419 | 3269 | 3269.0 | 84.79 | 84.8 | Biologic basis for interleukin-1 in disease. | C A Dinarello | Blood | 1996 | 8630372 | No |
420 | 3268 | 3268.0 | 88.8 | 88.8 | The adolescent brain and age-related behavioral manifestations. | L P Spear | Neurosci Biobehav Rev | 2000 | 10817843 | No |
421 | 13048 | 3262.0 | 306.13 | 76.5 | Improved methods for building protein models in electron density maps and the location of errors in these models. | T A Jones, J Y Zou, S W Cowan, M Kjeldgaard | Acta Crystallogr A | 1991 | 2025413 | Yes |
422 | 3259 | 3259.0 | 86.26 | 86.3 | Oxidative stress, antioxidants and stress tolerance. | Ron Mittler | Trends Plant Sci | 2002 | 12234732 | No |
423 | 3257 | 3257.0 | 130.59 | 130.6 | Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. | O W Griffith | Anal Biochem | 1980 | 7416462 | Yes |
424 | 6502 | 3251.0 | 0.0 | 0.0 | Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. | D H Hubel, T N Wiesel | J Physiol | 1962 | 14449617 | Yes |
425 | 3242 | 3242.0 | 0.0 | 0.0 | Estimation of average heterozygosity and genetic distance from a small number of individuals. | M Nei | Genetics | 1978 | 17248844 | Yes |
426 | 3232 | 3232.0 | 77.67 | 77.7 | Nonalcoholic fatty liver disease. | Paul Angulo | N Engl J Med | 2002 | 11961152 | No |
427 | 9694 | 3231.3 | 401.36 | 133.8 | A global measure of perceived stress. | S Cohen, T Kamarck, R Mermelstein | J Health Soc Behav | 1983 | 6668417 | Yes |
428 | 3230 | 3230.0 | 77.63 | 77.6 | Glutamate uptake. | N C Danbolt | Prog Neurobiol | 2001 | 11369436 | No |
429 | 9689 | 3229.7 | 320.88 | 107.0 | Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. | E R DeLong, D M DeLong, D L Clarke-Pearson | Biometrics | 1988 | 3203132 | Yes |
430 | 9666 | 3222.0 | 560.28 | 186.8 | Cancer statistics, 2015. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2015 | 25559415 | Yes |
431 | 3217 | 3217.0 | 93.09 | 93.1 | Inositol trisphosphate and diacylglycerol: two interacting second messengers. | M J Berridge | Annu Rev Biochem | 1987 | 3304132 | No |
432 | 6431 | 3215.5 | 168.16 | 84.1 | An integrative theory of prefrontal cortex function. | E K Miller, J D Cohen | Annu Rev Neurosci | 2001 | 11283309 | No |
433 | 3207 | 3207.0 | 85.31 | 85.3 | I-TASSER server for protein 3D structure prediction. | Yang Zhang | BMC Bioinformatics | 2008 | 18215316 | Yes |
434 | 3199 | 3199.0 | 69.13 | 69.1 | Profile hidden Markov models. | S R Eddy | Bioinformatics | 1998 | 9918945 | No |
435 | 12757 | 3189.2 | 329.93 | 82.5 | Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. | Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg | Genome Biol | 2009 | 19261174 | Yes |
436 | 19122 | 3187.0 | 1145.11 | 190.9 | Global cancer statistics, 2012. | Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin Jemal | CA Cancer J Clin | 2015 | 25651787 | Yes |
437 | 3169 | 3169.0 | 79.59 | 79.6 | The transforming growth factor-beta family. | J Massagué | Annu Rev Cell Biol | 1990 | 2177343 | No |
438 | 3168 | 3168.0 | 101.1 | 101.1 | Graphene: status and prospects. | A K Geim | Science | 2009 | 19541989 | Yes |
439 | 6333 | 3166.5 | 0.0 | 0.0 | Microsomal lipid peroxidation. | J A Buege, S D Aust | Methods Enzymol | 1978 | 672633 | Yes |
440 | 3163 | 3163.0 | 86.5 | 86.5 | The origins and the future of microfluidics. | George M Whitesides | Nature | 2006 | 16871203 | No |
441 | 3162 | 3162.0 | 0.0 | 0.0 | Diffusion-in-gel methods for immunological analysis. | O Ouchterlony | Prog Allergy | 1958 | 13578996 | Yes |
442 | 3159 | 3159.0 | 74.19 | 74.2 | Tolerance, danger, and the extended family. | P Matzinger | Annu Rev Immunol | 1994 | 8011301 | No |
443 | 3150 | 3150.0 | 85.55 | 85.5 | ABC transporters: from microorganisms to man. | C F Higgins | Annu Rev Cell Biol | 1992 | 1282354 | No |
444 | 3147 | 3147.0 | 0.0 | 0.0 | The magical number seven plus or minus two: some limits on our capacity for processing information. | G A Miller | Psychol Rev | 1956 | 13310704 | Yes |
445 | 3143 | 3143.0 | 104.86 | 104.9 | Modeling valuations for EuroQol health states. | P Dolan | Med Care | 1997 | 9366889 | Yes |
446 | 3138 | 3138.0 | 0.0 | 0.0 | Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. | S W Kessler | J Immunol | 1975 | 1102604 | Yes |
447 | 3125 | 3125.0 | 92.67 | 92.7 | Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. | Thomas Welton | Chem Rev | 1999 | 11849019 | Yes |
448 | 3113 | 3113.0 | 74.08 | 74.1 | Folding DNA to create nanoscale shapes and patterns. | Paul W K Rothemund | Nature | 2006 | 16541064 | Yes |
449 | 6216 | 3108.0 | 186.96 | 93.5 | Velvet: algorithms for de novo short read assembly using de Bruijn graphs. | Daniel R Zerbino, Ewan Birney | Genome Res | 2008 | 18349386 | Yes |
450 | 3107 | 3107.0 | 69.86 | 69.9 | Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. | H F Dvorak | N Engl J Med | 1986 | 3537791 | No |
451 | 3094 | 3094.0 | 64.51 | 64.5 | CpG-rich islands and the function of DNA methylation. | A P Bird | Nature | 1986 | 2423876 | No |
452 | 3085 | 3085.0 | 62.63 | 62.6 | STATs and gene regulation. | J E Darnell | Science | 1997 | 9287210 | No |
453 | 3082 | 3082.0 | 58.9 | 58.9 | Cell signaling by receptor tyrosine kinases. | J Schlessinger | Cell | 2000 | 11057895 | No |
454 | 3081 | 3081.0 | 172.9 | 172.9 | Executive functions. | Adele Diamond | Annu Rev Psychol | 2013 | 23020641 | No |
455 | 6159 | 3079.5 | 0.0 | 0.0 | Human malaria parasites in continuous culture. | W Trager, J B Jensen | Science | 1976 | 781840 | Yes |
456 | 6152 | 3076.0 | 172.09 | 86.0 | The basics of epithelial-mesenchymal transition. | Raghu Kalluri, Robert A Weinberg | J Clin Invest | 2009 | 19487818 | No |
457 | 6146 | 3073.0 | 121.91 | 61.0 | The ubiquitin system. | A Hershko, A Ciechanover | Annu Rev Biochem | 1998 | 9759494 | No |
458 | 3071 | 3071.0 | 68.35 | 68.3 | Activators and target genes of Rel/NF-kappaB transcription factors. | H L Pahl | Oncogene | 1999 | 10602461 | No |
459 | 3070 | 3070.0 | 100.07 | 100.1 | Emerging adulthood. A theory of development from the late teens through the twenties. | J J Arnett | Am Psychol | 2000 | 10842426 | Yes |
460 | 6134 | 3067.0 | 128.84 | 64.4 | Statistical significance for genomewide studies. | John D Storey, Robert Tibshirani | Proc Natl Acad Sci U S A | 2003 | 12883005 | Yes |
461 | 3062 | 3062.0 | 73.05 | 73.0 | WHAT IF: a molecular modeling and drug design program. | G Vriend | J Mol Graph | 1990 | 2268628 | Yes |
462 | 6121 | 3060.5 | 136.98 | 68.5 | Angiogenesis in cancer and other diseases. | P Carmeliet, R K Jain | Nature | 2000 | 11001068 | No |
463 | 6105 | 3052.5 | 235.44 | 117.7 | Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. | Laurent Excoffier, Heidi E L Lischer | Mol Ecol Resour | 2010 | 21565059 | Yes |
464 | 21345 | 3049.3 | 498.88 | 71.3 | UCSF Chimera--a visualization system for exploratory research and analysis. | Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin | J Comput Chem | 2004 | 15264254 | Yes |
465 | 3044 | 3044.0 | 75.41 | 75.4 | Neural networks and physical systems with emergent collective computational abilities. | J J Hopfield | Proc Natl Acad Sci U S A | 1982 | 6953413 | Yes |
466 | 9117 | 3039.0 | 313.17 | 104.4 | Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. | R M Palmer, A G Ferrige, S Moncada | Nature | 1987 | 3495737 | Yes |
467 | 3025 | 3025.0 | 75.17 | 75.2 | Wound healing--aiming for perfect skin regeneration. | P Martin | Science | 1997 | 9082989 | No |
468 | 3023 | 3023.0 | 74.99 | 75.0 | Photoelectrochemical cells. | M Grätzel | Nature | 2001 | 11713540 | Yes |
469 | 3021 | 3021.0 | 87.69 | 87.7 | EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. | W Klimesch | Brain Res Brain Res Rev | 1999 | 10209231 | No |
470 | 6017 | 3008.5 | 146.6 | 73.3 | Inference of macromolecular assemblies from crystalline state. | Evgeny Krissinel, Kim Henrick | J Mol Biol | 2007 | 17681537 | Yes |
471 | 3004 | 3004.0 | 99.25 | 99.2 | Functions of DNA methylation: islands, start sites, gene bodies and beyond. | Peter A Jones | Nat Rev Genet | 2012 | 22641018 | No |
472 | 3000 | 3000.0 | 79.8 | 79.8 | The pathobiology of diabetic complications: a unifying mechanism. | Michael Brownlee | Diabetes | 2005 | 15919781 | No |
473 | 2999 | 2999.0 | 70.81 | 70.8 | Cadherin cell adhesion receptors as a morphogenetic regulator. | M Takeichi | Science | 1991 | 2006419 | No |
474 | 2998 | 2998.0 | 0.0 | 0.0 | A study of fixation for electron microscopy. | G E Palade | J Exp Med | 1952 | 14927794 | Yes |
475 | 2996 | 2996.0 | 76.77 | 76.8 | The basis of anisotropic water diffusion in the nervous system - a technical review. | Christian Beaulieu | NMR Biomed | 2002 | 12489094 | No |
476 | 2991 | 2991.0 | 83.62 | 83.6 | Hay fever, hygiene, and household size. | D P Strachan | BMJ | 1989 | 2513902 | Yes |
477 | 2991 | 2991.0 | 0.0 | 0.0 | Towards a network theory of the immune system. | N K Jerne | Ann Immunol (Paris) | 1974 | 4142565 | No |
478 | 2971 | 2971.0 | 0.0 | 0.0 | The gel-filtration behaviour of proteins related to their molecular weights over a wide range. | P Andrews | Biochem J | 1965 | 5862401 | Yes |
479 | 2969 | 2969.0 | 0.0 | 0.0 | A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. | S Hakomori | J Biochem | 1964 | 14135466 | Yes |
480 | 2957 | 2957.0 | 0.0 | 0.0 | Gene action in the X-chromosome of the mouse (Mus musculus L.). | M F Lyon | Nature | 1961 | 13764598 | Yes |
481 | 5908 | 2954.0 | 125.47 | 62.7 | Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. | D B Smith, K S Johnson | Gene | 1988 | 3047011 | Yes |
482 | 2947 | 2947.0 | 0.0 | 0.0 | Transformed up-down methods in psychoacoustics. | H Levitt | J Acoust Soc Am | 1971 | 5541744 | Yes |
483 | 2946 | 2946.0 | 76.59 | 76.6 | How do you feel? Interoception: the sense of the physiological condition of the body. | A D Craig | Nat Rev Neurosci | 2002 | 12154366 | No |
484 | 2938 | 2938.0 | 64.97 | 65.0 | Mechanisms of angiogenesis and arteriogenesis. | P Carmeliet | Nat Med | 2000 | 10742145 | No |
485 | 2936 | 2936.0 | 61.41 | 61.4 | The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. | Isaiah J Fidler | Nat Rev Cancer | 2003 | 12778135 | No |
486 | 2932 | 2932.0 | 74.18 | 74.2 | Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. | Ting-Chao Chou | Pharmacol Rev | 2006 | 16968952 | No |
487 | 5850 | 2925.0 | 227.66 | 113.8 | Management of hepatocellular carcinoma: an update. | Jordi Bruix, Morris Sherman | Hepatology | 2011 | 21374666 | No |
488 | 5844 | 2922.0 | 170.44 | 85.2 | Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. | S Duval, R Tweedie | Biometrics | 2000 | 10877304 | Yes |
489 | 2919 | 2919.0 | 0.0 | 0.0 | Notes on sugar determination. | M Smogyi | J Biol Chem | 1952 | 14938350 | Yes |
490 | 2917 | 2917.0 | 91.34 | 91.3 | Matrix metalloproteinases and their inhibitors in connective tissue remodeling. | J F Woessner | FASEB J | 1991 | 1850705 | No |
491 | 2914 | 2914.0 | 65.12 | 65.1 | Angiogenesis in health and disease. | Peter Carmeliet | Nat Med | 2003 | 12778163 | No |
492 | 5826 | 2913.0 | 149.29 | 74.6 | The plant immune system. | Jonathan D G Jones, Jeffery L Dangl | Nature | 2006 | 17108957 | No |
493 | 2912 | 2912.0 | 0.0 | 0.0 | Catheter replacement of the needle in percutaneous arteriography; a new technique. | S I Seldinger | Acta radiol | 1953 | 13057644 | Yes |
494 | 8733 | 2911.0 | 233.35 | 77.8 | Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nucleic Acids Res | 2009 | 19033363 | Yes |
495 | 8714 | 2904.7 | 243.63 | 81.2 | Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. | Y Gavrieli, Y Sherman, S A Ben-Sasson | J Cell Biol | 1992 | 1400587 | Yes |
496 | 8714 | 2904.7 | 180.33 | 60.1 | Significance analysis of microarrays applied to the ionizing radiation response. | V G Tusher, R Tibshirani, G Chu | Proc Natl Acad Sci U S A | 2001 | 11309499 | Yes |
497 | 2903 | 2903.0 | 80.43 | 80.4 | Mesenchymal stem cells. | A I Caplan | J Orthop Res | 1991 | 1870029 | Yes |
498 | 5805 | 2902.5 | 140.57 | 70.3 | Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. | C Tuerk, L Gold | Science | 1990 | 2200121 | Yes |
499 | 2902 | 2902.0 | 72.0 | 72.0 | Phase separation of integral membrane proteins in Triton X-114 solution. | C Bordier | J Biol Chem | 1981 | 6257680 | Yes |
500 | 2901 | 2901.0 | 69.89 | 69.9 | Chemokines--chemotactic cytokines that mediate inflammation. | A D Luster | N Engl J Med | 1998 | 9459648 | No |
501 | 2901 | 2901.0 | 91.15 | 91.2 | Development of a classification system for periodontal diseases and conditions. | G C Armitage | Ann Periodontol | 1999 | 10863370 | No |
502 | 2897 | 2897.0 | 62.62 | 62.6 | Alzheimer's disease is a synaptic failure. | Dennis J Selkoe | Science | 2002 | 12399581 | No |
503 | 8679 | 2893.0 | 402.67 | 134.2 | HTSeq--a Python framework to work with high-throughput sequencing data. | Simon Anders, Paul Theodor Pyl, Wolfgang Huber | Bioinformatics | 2015 | 25260700 | Yes |
504 | 5774 | 2887.0 | 129.65 | 64.8 | Toll-like receptor signalling. | Shizuo Akira, Kiyoshi Takeda | Nat Rev Immunol | 2004 | 15229469 | No |
505 | 2883 | 2883.0 | 63.5 | 63.5 | Protein folding and misfolding. | Christopher M Dobson | Nature | 2003 | 14685248 | No |
506 | 5755 | 2877.5 | 0.0 | 0.0 | Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. | C Beauchamp, I Fridovich | Anal Biochem | 1971 | 4943714 | Yes |
507 | 8628 | 2876.0 | 190.43 | 63.5 | Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. | Benjamin P Lewis, Christopher B Burge, David P Bartel | Cell | 2005 | 15652477 | Yes |
508 | 2874 | 2874.0 | 0.0 | 0.0 | Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. | W C Schneider | J Biol Chem | 1945 | 21005736 | Yes |
509 | 2872 | 2872.0 | 118.43 | 118.4 | Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. | T E Moffitt | Psychol Rev | 1993 | 8255953 | No |
510 | 5742 | 2871.0 | 163.89 | 81.9 | Inositol trisphosphate, a novel second messenger in cellular signal transduction. | M J Berridge, R F Irvine | Nature | 1984 | 6095092 | No |
511 | 2870 | 2870.0 | 51.63 | 51.6 | One-step gene disruption in yeast. | R J Rothstein | Methods Enzymol | 1983 | 6310324 | Yes |
512 | 8608 | 2869.3 | 0.0 | 0.0 | The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. | R J Havel, H A Eder, J H Bragdon | J Clin Invest | 1955 | 13252080 | Yes |
513 | 2865 | 2865.0 | 94.08 | 94.1 | An empirical correction for absorption anisotropy. | R H Blessing | Acta Crystallogr A | 1995 | 7702794 | Yes |
514 | 2864 | 2864.0 | 111.99 | 112.0 | Half a century of research on the Stroop effect: an integrative review. | C M MacLeod | Psychol Bull | 1991 | 2034749 | No |
515 | 2861 | 2861.0 | 85.9 | 85.9 | Drug combination studies and their synergy quantification using the Chou-Talalay method. | Ting-Chao Chou | Cancer Res | 2010 | 20068163 | Yes |
516 | 2860 | 2860.0 | 0.0 | 0.0 | Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. | B E Murphy | J Clin Endocrinol Metab | 1967 | 4291524 | Yes |
517 | 2857 | 2857.0 | 0.0 | 0.0 | Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. | L Svennerholm | Biochim Biophys Acta | 1957 | 13436486 | Yes |
518 | 5709 | 2854.5 | 135.81 | 67.9 | MicroRNA signatures in human cancers. | George A Calin, Carlo M Croce | Nat Rev Cancer | 2006 | 17060945 | No |
519 | 8546 | 2848.7 | 0.0 | 0.0 | Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. | G Fairbanks, T L Steck, D F Wallach | Biochemistry | 1971 | 4326772 | Yes |
520 | 2846 | 2846.0 | 93.61 | 93.6 | Health promotion by social cognitive means. | Albert Bandura | Health Educ Behav | 2004 | 15090118 | Yes |
521 | 5683 | 2841.5 | 0.0 | 0.0 | Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. | J Glowinski, L L Iversen | J Neurochem | 1966 | 5950056 | Yes |
522 | 11332 | 2833.0 | 451.85 | 113.0 | APACHE II: a severity of disease classification system. | W A Knaus, E A Draper, D P Wagner, J E Zimmerman | Crit Care Med | 1985 | 3928249 | Yes |
523 | 2829 | 2829.0 | 54.99 | 55.0 | RNA interference. | Gregory J Hannon | Nature | 2002 | 12110901 | No |
524 | 5657 | 2828.5 | 103.96 | 52.0 | The language of covalent histone modifications. | B D Strahl, C D Allis | Nature | 2000 | 10638745 | Yes |
525 | 5646 | 2823.0 | 0.0 | 0.0 | Pain mechanisms: a new theory. | R Melzack, P D Wall | Science | 1965 | 5320816 | No |
526 | 2820 | 2820.0 | 0.0 | 0.0 | A study of the adrenotropic receptors. | R P Ahlquist | Am J Physiol | 1948 | 18882199 | Yes |
527 | 2819 | 2819.0 | 0.0 | 0.0 | A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. | E A Gehan | Biometrika | 1965 | 14341275 | Yes |
528 | 16902 | 2817.0 | 670.38 | 111.7 | Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. | Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G Conde | J Biomed Inform | 2009 | 18929686 | Yes |
529 | 2810 | 2810.0 | 75.46 | 75.5 | Origin and physiological roles of inflammation. | Ruslan Medzhitov | Nature | 2008 | 18650913 | No |
530 | 2809 | 2809.0 | 59.68 | 59.7 | Principles of CDK regulation. | D O Morgan | Nature | 1995 | 7877684 | No |
531 | 11230 | 2807.5 | 460.56 | 115.1 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | BMJ | 2009 | 19622551 | No |
532 | 2807 | 2807.0 | 69.17 | 69.2 | Obesity as a medical problem. | P G Kopelman | Nature | 2000 | 10766250 | No |
533 | 11221 | 2805.2 | 281.42 | 70.4 | Haploview: analysis and visualization of LD and haplotype maps. | J C Barrett, B Fry, J Maller, M J Daly | Bioinformatics | 2005 | 15297300 | Yes |
534 | 5607 | 2803.5 | 0.0 | 0.0 | Assessment of outcome after severe brain damage. | B Jennett, M Bond | Lancet | 1975 | 46957 | Yes |
535 | 5606 | 2803.0 | 0.0 | 0.0 | A method for determining the sedimentation behavior of enzymes: application to protein mixtures. | R G Martin, B N Ames | J Biol Chem | 1961 | 13767412 | Yes |
536 | 5603 | 2801.5 | 0.0 | 0.0 | A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. | S Reitman, S Frankel | Am J Clin Pathol | 1957 | 13458125 | Yes |
537 | 5593 | 2796.5 | 164.1 | 82.0 | Projections of global mortality and burden of disease from 2002 to 2030. | Colin D Mathers, Dejan Loncar | PLoS Med | 2006 | 17132052 | Yes |
538 | 2795 | 2795.0 | 86.19 | 86.2 | Non-coding RNAs in human disease. | Manel Esteller | Nat Rev Genet | 2011 | 22094949 | No |
539 | 2794 | 2794.0 | 94.33 | 94.3 | Role of oxidative stress in development of complications in diabetes. | J W Baynes | Diabetes | 1991 | 2010041 | No |
540 | 5588 | 2794.0 | 147.18 | 73.6 | Voxel-based morphometry--the methods. | J Ashburner, K J Friston | Neuroimage | 2000 | 10860804 | No |
541 | 2794 | 2794.0 | 93.22 | 93.2 | Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. | Sarah E Barlow | Pediatrics | 2007 | 18055651 | Yes |
542 | 5582 | 2791.0 | 153.62 | 76.8 | The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. | J Vieira, J Messing | Gene | 1982 | 6295879 | Yes |
543 | 11147 | 2786.8 | 0.0 | 0.0 | Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. | P W Rigby, M Dieckmann, C Rhodes, P Berg | J Mol Biol | 1977 | 881736 | Yes |
544 | 2783 | 2783.0 | 128.67 | 128.7 | The quality of care. How can it be assessed? | A Donabedian | JAMA | 1988 | 3045356 | No |
545 | 5552 | 2776.0 | 0.0 | 0.0 | The fluid mosaic model of the structure of cell membranes. | S J Singer, G L Nicolson | Science | 1972 | 4333397 | Yes |
546 | 5546 | 2773.0 | 110.58 | 55.3 | High-efficiency transformation of mammalian cells by plasmid DNA. | C Chen, H Okayama | Mol Cell Biol | 1987 | 3670292 | Yes |
547 | 2773 | 2773.0 | 0.0 | 0.0 | Efficient trace-labelling of proteins with iodine. | A S McFARLANE | Nature | 1958 | 13566175 | Yes |
548 | 2769 | 2769.0 | 61.43 | 61.4 | Cardiac excitation-contraction coupling. | Donald M Bers | Nature | 2002 | 11805843 | No |
549 | 2766 | 2766.0 | 92.07 | 92.1 | Hepatocellular carcinoma. | Hashem B El-Serag | N Engl J Med | 2011 | 21992124 | No |
550 | 2765 | 2765.0 | 97.52 | 97.5 | The processing-speed theory of adult age differences in cognition. | T A Salthouse | Psychol Rev | 1996 | 8759042 | No |
551 | 2763 | 2763.0 | 0.0 | 0.0 | Measurement of pain. | E C Huskisson | Lancet | 1974 | 4139420 | Yes |
552 | 5515 | 2757.5 | 152.5 | 76.2 | Fast and accurate long-read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2010 | 20080505 | Yes |
553 | 8270 | 2756.7 | 179.62 | 59.9 | Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. | C M Gorman, L F Moffat, B H Howard | Mol Cell Biol | 1982 | 6960240 | Yes |
554 | 2755 | 2755.0 | 84.33 | 84.3 | Implications of normal brain development for the pathogenesis of schizophrenia. | D R Weinberger | Arch Gen Psychiatry | 1987 | 3606332 | Yes |
555 | 8254 | 2751.3 | 320.03 | 106.7 | Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. | Allison Tong, Peter Sainsbury, Jonathan Craig | Int J Qual Health Care | 2007 | 17872937 | Yes |
556 | 5500 | 2750.0 | 0.0 | 0.0 | The serial cultivation of human diploid cell strains. | L Hayflick, P S Moorhead | Exp Cell Res | 1961 | 13905658 | Yes |
557 | 5497 | 2748.5 | 133.48 | 66.7 | Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. | T C Chou, P Talalay | Adv Enzyme Regul | 1984 | 6382953 | Yes |
558 | 2747 | 2747.0 | 73.24 | 73.2 | Recent advances with liposomes as pharmaceutical carriers. | Vladimir P Torchilin | Nat Rev Drug Discov | 2005 | 15688077 | No |
559 | 5491 | 2745.5 | 244.55 | 122.3 | Revised methods for the Salmonella mutagenicity test. | D M Maron, B N Ames | Mutat Res | 1983 | 6341825 | Yes |
560 | 2738 | 2738.0 | 65.96 | 66.0 | Mitochondrial formation of reactive oxygen species. | Julio F Turrens | J Physiol | 2003 | 14561818 | No |
561 | 5473 | 2736.5 | 128.49 | 64.2 | Caspases: enemies within. | N A Thornberry, Y Lazebnik | Science | 1998 | 9721091 | No |
562 | 2727 | 2727.0 | 56.91 | 56.9 | Toll-like receptors and innate immunity. | R Medzhitov | Nat Rev Immunol | 2001 | 11905821 | No |
563 | 2726 | 2726.0 | 0.0 | 0.0 | Stereotaxic mapping of the monoamine pathways in the rat brain. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4109331 | Yes |
564 | 2725 | 2725.0 | 71.64 | 71.6 | Optimal two-stage designs for phase II clinical trials. | R Simon | Control Clin Trials | 1989 | 2702835 | Yes |
565 | 2722 | 2722.0 | 61.2 | 61.2 | Inflammatory bowel disease. | Daniel K Podolsky | N Engl J Med | 2002 | 12167685 | No |
566 | 2719 | 2719.0 | 66.65 | 66.7 | Cell death during development of the nervous system. | R W Oppenheim | Annu Rev Neurosci | 1991 | 2031577 | No |
567 | 24453 | 2717.0 | 683.11 | 75.9 | The Sequence Alignment/Map format and SAMtools. | Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin | Bioinformatics | 2009 | 19505943 | Yes |
568 | 2711 | 2711.0 | 87.89 | 87.9 | Psychometric properties of the strengths and difficulties questionnaire. | R Goodman | J Am Acad Child Adolesc Psychiatry | 2001 | 11699809 | Yes |
569 | 2708 | 2708.0 | 65.09 | 65.1 | Structure and function of telomeres. | E H Blackburn | Nature | 1991 | 1708110 | No |
570 | 10820 | 2705.0 | 372.1 | 93.0 | Cancer statistics, 2010. | Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth Ward | CA Cancer J Clin | 2010 | 20610543 | Yes |
571 | 2702 | 2702.0 | 116.49 | 116.5 | FreeSurfer. | Bruce Fischl | Neuroimage | 2012 | 22248573 | No |
572 | 2701 | 2701.0 | 77.61 | 77.6 | Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. | Y X Fu | Genetics | 1997 | 9335623 | Yes |
573 | 2701 | 2701.0 | 52.85 | 52.9 | Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. | P Schuck | Biophys J | 2000 | 10692345 | Yes |
574 | 5400 | 2700.0 | 175.59 | 87.8 | Tissue engineering. | R Langer, J P Vacanti | Science | 1993 | 8493529 | No |
575 | 13498 | 2699.6 | 543.24 | 108.6 | The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. | D J Buysse, C F Reynolds, T H Monk, S R Berman, D J Kupfer | Psychiatry Res | 1989 | 2748771 | Yes |
576 | 2699 | 2699.0 | 52.51 | 52.5 | Genome maintenance mechanisms for preventing cancer. | J H Hoeijmakers | Nature | 2001 | 11357144 | No |
577 | 5392 | 2696.0 | 133.98 | 67.0 | In vitro selection of RNA molecules that bind specific ligands. | A D Ellington, J W Szostak | Nature | 1990 | 1697402 | Yes |
578 | 2696 | 2696.0 | 0.0 | 0.0 | Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. | P Cuatrecasas | J Biol Chem | 1970 | 5432796 | Yes |
579 | 8086 | 2695.3 | 211.71 | 70.6 | MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. | Sudhir Kumar, Koichiro Tamura, Masatoshi Nei | Brief Bioinform | 2004 | 15260895 | Yes |
580 | 2693 | 2693.0 | 64.18 | 64.2 | Molecular chaperones in cellular protein folding. | F U Hartl | Nature | 1996 | 8637592 | No |
581 | 5374 | 2687.0 | 0.0 | 0.0 | A modified uronic acid carbazole reaction. | T Bitter, H M Muir | Anal Biochem | 1962 | 13971270 | Yes |
582 | 8056 | 2685.3 | 205.81 | 68.6 | TopHat: discovering splice junctions with RNA-Seq. | Cole Trapnell, Lior Pachter, Steven L Salzberg | Bioinformatics | 2009 | 19289445 | Yes |
583 | 2684 | 2684.0 | 0.0 | 0.0 | Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. | P Mitchell | Nature | 1961 | 13771349 | Yes |
584 | 2683 | 2683.0 | 125.49 | 125.5 | The short-form McGill Pain Questionnaire. | Ronald Melzack | Pain | 1987 | 3670870 | Yes |
585 | 5363 | 2681.5 | 126.5 | 63.2 | Oncomirs - microRNAs with a role in cancer. | Aurora Esquela-Kerscher, Frank J Slack | Nat Rev Cancer | 2006 | 16557279 | No |
586 | 5362 | 2681.0 | 127.98 | 64.0 | Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. | F W Studier, B A Moffatt | J Mol Biol | 1986 | 3537305 | Yes |
587 | 8028 | 2676.0 | 221.4 | 73.8 | Understanding the Warburg effect: the metabolic requirements of cell proliferation. | Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson | Science | 2009 | 19460998 | No |
588 | 5340 | 2670.0 | 182.98 | 91.5 | Measuring agreement in method comparison studies. | J M Bland, D G Altman | Stat Methods Med Res | 1999 | 10501650 | No |
589 | 5328 | 2664.0 | 124.72 | 62.4 | Oxidants, oxidative stress and the biology of ageing. | T Finkel, N J Holbrook | Nature | 2000 | 11089981 | No |
590 | 10655 | 2663.8 | 387.2 | 96.8 | A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. | Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge Krieg | J Chem Phys | 2010 | 20423165 | Yes |
591 | 2656 | 2656.0 | 0.0 | 0.0 | A gene complex controlling segmentation in Drosophila. | E B Lewis | Nature | 1978 | 103000 | Yes |
592 | 5303 | 2651.5 | 132.52 | 66.3 | Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. | D Hanahan, J Folkman | Cell | 1996 | 8756718 | No |
593 | 2648 | 2648.0 | 82.14 | 82.1 | Primate models of movement disorders of basal ganglia origin. | M R DeLong | Trends Neurosci | 1990 | 1695404 | No |
594 | 2647 | 2647.0 | 62.33 | 62.3 | TGFbeta in Cancer. | Joan Massagué | Cell | 2008 | 18662538 | No |
595 | 2646 | 2646.0 | 0.0 | 0.0 | The genetical structure of populations. | S Wright | Ann Eugen | 1951 | 24540312 | Yes |
596 | 5288 | 2644.0 | 165.17 | 82.6 | Glutathione. | A Meister, M E Anderson | Annu Rev Biochem | 1983 | 6137189 | No |
597 | 2636 | 2636.0 | 49.3 | 49.3 | Wnt signaling and cancer. | P Polakis | Genes Dev | 2000 | 10921899 | No |
598 | 2635 | 2635.0 | 82.58 | 82.6 | Estimation of metabolite concentrations from localized in vivo proton NMR spectra. | S W Provencher | Magn Reson Med | 1993 | 8139448 | Yes |
599 | 2631 | 2631.0 | 0.0 | 0.0 | A simple technique for demonstrating centromeric heterochromatin. | A T Sumner | Exp Cell Res | 1972 | 4117921 | Yes |
600 | 2627 | 2627.0 | 90.37 | 90.4 | Essential oils: their antibacterial properties and potential applications in foods--a review. | Sara Burt | Int J Food Microbiol | 2004 | 15246235 | No |
601 | 7869 | 2623.0 | 264.45 | 88.1 | Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. | R A Deyo, D C Cherkin, M A Ciol | J Clin Epidemiol | 1992 | 1607900 | Yes |
602 | 2623 | 2623.0 | 86.16 | 86.2 | No adjustments are needed for multiple comparisons. | K J Rothman | Epidemiology | 1990 | 2081237 | Yes |
603 | 5238 | 2619.0 | 0.0 | 0.0 | Some quantitative uses of drug antagonists. | O Arunlakshana, H O Schild | Br J Pharmacol Chemother | 1959 | 13651579 | Yes |
604 | 10457 | 2614.2 | 230.09 | 57.5 | Cluster analysis and display of genome-wide expression patterns. | M B Eisen, P T Spellman, P O Brown, D Botstein | Proc Natl Acad Sci U S A | 1998 | 9843981 | Yes |
605 | 2609 | 2609.0 | 0.0 | 0.0 | Analysis of gene diversity in subdivided populations. | M Nei | Proc Natl Acad Sci U S A | 1973 | 4519626 | Yes |
606 | 2609 | 2609.0 | 59.92 | 59.9 | Nuclear factor-kappaB in cancer development and progression. | Michael Karin | Nature | 2006 | 16724054 | No |
607 | 2603 | 2603.0 | 54.67 | 54.7 | Papillomaviruses and cancer: from basic studies to clinical application. | Harald zur Hausen | Nat Rev Cancer | 2002 | 12044010 | No |
608 | 5203 | 2601.5 | 187.45 | 93.7 | A method of comparing the areas under receiver operating characteristic curves derived from the same cases. | J A Hanley, B J McNeil | Radiology | 1983 | 6878708 | Yes |
609 | 5196 | 2598.0 | 183.65 | 91.8 | A simple, rapid, and sensitive DNA assay procedure. | C Labarca, K Paigen | Anal Biochem | 1980 | 6158890 | Yes |
610 | 5192 | 2596.0 | 106.94 | 53.5 | Establishment in culture of pluripotential cells from mouse embryos. | M J Evans, M H Kaufman | Nature | 1981 | 7242681 | Yes |
611 | 2593 | 2593.0 | 82.93 | 82.9 | Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. | B Samuelsson | Science | 1983 | 6301011 | Yes |
612 | 2593 | 2593.0 | 46.05 | 46.0 | Mechanisms underlying ubiquitination. | C M Pickart | Annu Rev Biochem | 2001 | 11395416 | No |
613 | 2588 | 2588.0 | 0.0 | 0.0 | The membrane actions of anesthetics and tranquilizers. | P Seeman | Pharmacol Rev | 1972 | 4565956 | No |
614 | 5173 | 2586.5 | 190.97 | 95.5 | Longitudinal data analysis for discrete and continuous outcomes. | S L Zeger, K Y Liang | Biometrics | 1986 | 3719049 | Yes |
615 | 5173 | 2586.5 | 113.54 | 56.8 | Emergence of scaling in random networks | Barabasi, Albert | Science | 1999 | 10521342 | Yes |
616 | 5172 | 2586.0 | 176.44 | 88.2 | mTOR signaling in growth control and disease. | Mathieu Laplante, David M Sabatini | Cell | 2012 | 22500797 | No |
617 | 2584 | 2584.0 | 60.37 | 60.4 | Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. | S A Bustin | J Mol Endocrinol | 2000 | 11013345 | No |
618 | 5163 | 2581.5 | 117.28 | 58.6 | Signal transduction by receptors with tyrosine kinase activity. | A Ullrich, J Schlessinger | Cell | 1990 | 2158859 | No |
619 | 2580 | 2580.0 | 53.75 | 53.8 | Interleukin-12 and the regulation of innate resistance and adaptive immunity. | Giorgio Trinchieri | Nat Rev Immunol | 2003 | 12563297 | No |
620 | 2579 | 2579.0 | 59.72 | 59.7 | Cell adhesion: the molecular basis of tissue architecture and morphogenesis. | B M Gumbiner | Cell | 1996 | 8608588 | No |
621 | 2579 | 2579.0 | 67.8 | 67.8 | The resurgence of platinum-based cancer chemotherapy. | Lloyd Kelland | Nat Rev Cancer | 2007 | 17625587 | No |
622 | 2576 | 2576.0 | 53.16 | 53.2 | The danger model: a renewed sense of self. | Polly Matzinger | Science | 2002 | 11951032 | Yes |
623 | 2569 | 2569.0 | 0.0 | 0.0 | The biology of oxygen radicals. | I Fridovich | Science | 1978 | 210504 | Yes |
624 | 2569 | 2569.0 | 120.55 | 120.5 | Detecting alcoholism. The CAGE questionnaire. | J A Ewing | JAMA | 1984 | 6471323 | Yes |
625 | 2568 | 2568.0 | 64.6 | 64.6 | The nerve growth factor 35 years later. | R Levi-Montalcini | Science | 1987 | 3306916 | No |
626 | 5136 | 2568.0 | 180.42 | 90.2 | The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. | Stephen B Edge, Carolyn C Compton | Ann Surg Oncol | 2010 | 20180029 | No |
627 | 5131 | 2565.5 | 152.53 | 76.3 | The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. | Taro Kawai, Shizuo Akira | Nat Immunol | 2010 | 20404851 | No |
628 | 2565 | 2565.0 | 52.43 | 52.4 | Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. | Shimon Sakaguchi | Annu Rev Immunol | 2004 | 15032588 | No |
629 | 5128 | 2564.0 | 161.2 | 80.6 | Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. | K Tamura, M Nei | Mol Biol Evol | 1993 | 8336541 | Yes |
630 | 5126 | 2563.0 | 0.0 | 0.0 | Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. | L A Greene, A S Tischler | Proc Natl Acad Sci U S A | 1976 | 1065897 | Yes |
631 | 2562 | 2562.0 | 0.0 | 0.0 | The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. | R R Porter | Biochem J | 1959 | 14434282 | Yes |
632 | 2555 | 2555.0 | 0.0 | 0.0 | Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. | O Smithies | Biochem J | 1955 | 13276348 | Yes |
633 | 5103 | 2551.5 | 136.17 | 68.1 | Exploring the full spectrum of macrophage activation. | David M Mosser, Justin P Edwards | Nat Rev Immunol | 2008 | 19029990 | No |
634 | 7649 | 2549.7 | 176.43 | 58.8 | The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. | R C Lee, R L Feinbaum, V Ambros | Cell | 1993 | 8252621 | Yes |
635 | 2548 | 2548.0 | 62.72 | 62.7 | Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. | E C Butcher | Cell | 1991 | 1760836 | No |
636 | 2547 | 2547.0 | 55.58 | 55.6 | G1 phase progression: cycling on cue. | C J Sherr | Cell | 1994 | 7954821 | No |
637 | 2542 | 2542.0 | 81.04 | 81.0 | What are the functional consequences of neurocognitive deficits in schizophrenia? | M F Green | Am J Psychiatry | 1996 | 8610818 | No |
638 | 5082 | 2541.0 | 0.0 | 0.0 | Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. | J Sedlak, R H Lindsay | Anal Biochem | 1968 | 4973948 | Yes |
639 | 2541 | 2541.0 | 73.03 | 73.0 | Delayed neuronal death in the gerbil hippocampus following ischemia. | T Kirino | Brain Res | 1982 | 7093691 | Yes |
640 | 5066 | 2533.0 | 105.61 | 52.8 | Innate immune recognition. | Charles A Janeway, Ruslan Medzhitov | Annu Rev Immunol | 2002 | 11861602 | No |
641 | 2532 | 2532.0 | 0.0 | 0.0 | Elastic properties of lipid bilayers: theory and possible experiments. | W Helfrich | Z Naturforsch C | 1973 | 4273690 | Yes |
642 | 20198 | 2524.8 | 457.48 | 57.2 | The Protein Data Bank. | H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E Bourne | Nucleic Acids Res | 2000 | 10592235 | Yes |
643 | 5043 | 2521.5 | 172.86 | 86.4 | Computed tomography--an increasing source of radiation exposure. | David J Brenner, Eric J Hall | N Engl J Med | 2007 | 18046031 | No |
644 | 2521 | 2521.0 | 67.65 | 67.7 | Predictive reward signal of dopamine neurons. | W Schultz | J Neurophysiol | 1998 | 9658025 | No |
645 | 5039 | 2519.5 | 0.0 | 0.0 | The Social Readjustment Rating Scale. | T H Holmes, R H Rahe | J Psychosom Res | 1967 | 6059863 | Yes |
646 | 2519 | 2519.0 | 0.0 | 0.0 | On the number of segregating sites in genetical models without recombination. | G A Watterson | Theor Popul Biol | 1975 | 1145509 | Yes |
647 | 2516 | 2516.0 | 96.41 | 96.4 | You want to measure coping but your protocol's too long: consider the brief COPE. | C S Carver | Int J Behav Med | 1997 | 16250744 | Yes |
648 | 7529 | 2509.7 | 226.66 | 75.6 | Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. | G Evanno, S Regnaut, J Goudet | Mol Ecol | 2005 | 15969739 | Yes |
649 | 2509 | 2509.0 | 77.8 | 77.8 | Secretory products of macrophages. | C F Nathan | J Clin Invest | 1987 | 3543052 | No |
650 | 2509 | 2509.0 | 60.51 | 60.5 | Memory--a century of consolidation. | J L McGaugh | Science | 2000 | 10634773 | No |
651 | 5017 | 2508.5 | 158.58 | 79.3 | The L-arginine-nitric oxide pathway. | S Moncada, A Higgs | N Engl J Med | 1993 | 7504210 | No |
652 | 2493 | 2493.0 | 50.79 | 50.8 | Universal control mechanism regulating onset of M-phase. | P Nurse | Nature | 1990 | 2138713 | No |
653 | 4984 | 2492.0 | 0.0 | 0.0 | Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. | P J Fraker, J C Speck | Biochem Biophys Res Commun | 1978 | 637870 | Yes |
654 | 2492 | 2492.0 | 0.0 | 0.0 | The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. | M L Anson | J Gen Physiol | 1938 | 19873094 | Yes |
655 | 4983 | 2491.5 | 0.0 | 0.0 | A diagnostic interview: the schedule for affective disorders and schizophrenia. | J Endicott, R L Spitzer | Arch Gen Psychiatry | 1978 | 678037 | Yes |
656 | 2490 | 2490.0 | 0.0 | 0.0 | Models for the specific adhesion of cells to cells. | G I Bell | Science | 1978 | 347575 | No |
657 | 4975 | 2487.5 | 160.7 | 80.3 | Complex brain networks: graph theoretical analysis of structural and functional systems. | Ed Bullmore, Olaf Sporns | Nat Rev Neurosci | 2009 | 19190637 | No |
658 | 4963 | 2481.5 | 109.8 | 54.9 | Inflammation and cancer: back to Virchow? | F Balkwill, A Mantovani | Lancet | 2001 | 11229684 | No |
659 | 2481 | 2481.0 | 58.54 | 58.5 | Prostaglandins and leukotrienes: advances in eicosanoid biology. | C D Funk | Science | 2001 | 11729303 | No |
660 | 2479 | 2479.0 | 69.32 | 69.3 | Cellular and molecular mechanisms of fibrosis. | T A Wynn | J Pathol | 2008 | 18161745 | No |
661 | 2477 | 2477.0 | 0.0 | 0.0 | Oxygen-dependent microbial killing by phagocytes (first of two parts). | B M Babior | N Engl J Med | 1978 | 24176 | Yes |
662 | 2474 | 2474.0 | 0.0 | 0.0 | The catecholamine hypothesis of affective disorders: a review of supporting evidence. | J J Schildkraut | Am J Psychiatry | 1965 | 5319766 | No |
663 | 2474 | 2474.0 | 95.05 | 95.0 | Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. | Joseph P Weir | J Strength Cond Res | 2005 | 15705040 | No |
664 | 2471 | 2471.0 | 0.0 | 0.0 | The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. | S Boyden | J Exp Med | 1962 | 13872176 | Yes |
665 | 2466 | 2466.0 | 90.22 | 90.2 | Measures of reliability in sports medicine and science. | W G Hopkins | Sports Med | 2000 | 10907753 | Yes |
666 | 9859 | 2464.8 | 305.02 | 76.3 | Establishing a standard definition for child overweight and obesity worldwide: international survey. | T J Cole, M C Bellizzi, K M Flegal, W H Dietz | BMJ | 2000 | 10797032 | Yes |
667 | 4920 | 2460.0 | 0.0 | 0.0 | Electrochemical photolysis of water at a semiconductor electrode. | A Fujishima, K Honda | Nature | 1972 | 12635268 | Yes |
668 | 4917 | 2458.5 | 479.0 | 239.5 | A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. | Terry K Koo, Mae Y Li | J Chiropr Med | 2016 | 27330520 | Yes |
669 | 4914 | 2457.0 | 146.85 | 73.4 | Adherence to medication. | Lars Osterberg, Terrence Blaschke | N Engl J Med | 2005 | 16079372 | No |
670 | 2451 | 2451.0 | 73.7 | 73.7 | RELION: implementation of a Bayesian approach to cryo-EM structure determination. | Sjors H W Scheres | J Struct Biol | 2012 | 23000701 | Yes |
671 | 4891 | 2445.5 | 199.47 | 99.7 | A feature-integration theory of attention. | A M Treisman, G Gelade | Cogn Psychol | 1980 | 7351125 | Yes |
672 | 2444 | 2444.0 | 59.29 | 59.3 | Autophagy: process and function. | Noboru Mizushima | Genes Dev | 2007 | 18006683 | No |
673 | 2440 | 2440.0 | 0.0 | 0.0 | Perceived exertion as an indicator of somatic stress. | G Borg | Scand J Rehabil Med | 1970 | 5523831 | Yes |
674 | 2438 | 2438.0 | 54.92 | 54.9 | Bone resorption by osteoclasts. | S L Teitelbaum | Science | 2000 | 10968780 | No |
675 | 2437 | 2437.0 | 64.24 | 64.2 | The genetic legacy of the Quaternary ice ages. | G Hewitt | Nature | 2000 | 10879524 | No |
676 | 2433 | 2433.0 | 55.3 | 55.3 | Social controls on cell survival and cell death. | M C Raff | Nature | 1992 | 1557121 | No |
677 | 4863 | 2431.5 | 218.45 | 109.2 | The qualitative content analysis process. | Satu Elo, Helvi Kyngäs | J Adv Nurs | 2008 | 18352969 | Yes |
678 | 2426 | 2426.0 | 0.0 | 0.0 | Satellite cell of skeletal muscle fibers. | A Mauro | J Biophys Biochem Cytol | 1961 | 13768451 | Yes |
679 | 2425 | 2425.0 | 65.83 | 65.8 | Dominant forces in protein folding. | K A Dill | Biochemistry | 1990 | 2207096 | No |
680 | 7261 | 2420.3 | 178.82 | 59.6 | Pathogen recognition and innate immunity. | Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi | Cell | 2006 | 16497588 | No |
681 | 4839 | 2419.5 | 136.57 | 68.3 | Unified segmentation. | John Ashburner, Karl J Friston | Neuroimage | 2005 | 15955494 | Yes |
682 | 2412 | 2412.0 | 0.0 | 0.0 | Colorimetric assay of catalase. | A K Sinha | Anal Biochem | 1972 | 4556490 | Yes |
683 | 4817 | 2408.5 | 0.0 | 0.0 | Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. | S Marklund, G Marklund | Eur J Biochem | 1974 | 4215654 | Yes |
684 | 2405 | 2405.0 | 0.0 | 0.0 | Transduction of linked genetic characters of the host by bacteriophage P1. | E S Lennox | Virology | 1955 | 13267987 | Yes |
685 | 4808 | 2404.0 | 117.03 | 58.5 | Calculation of protein extinction coefficients from amino acid sequence data. | S C Gill, P H von Hippel | Anal Biochem | 1989 | 2610349 | Yes |
686 | 2404 | 2404.0 | 58.08 | 58.1 | Vascular endothelial growth factor: basic science and clinical progress. | Napoleone Ferrara | Endocr Rev | 2004 | 15294883 | No |
687 | 4806 | 2403.0 | 0.0 | 0.0 | Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. | J V Durnin, J Womersley | Br J Nutr | 1974 | 4843734 | Yes |
688 | 4783 | 2391.5 | 158.5 | 79.2 | The neural basis of drug craving: an incentive-sensitization theory of addiction. | T E Robinson, K C Berridge | Brain Res Brain Res Rev | 1993 | 8401595 | No |
689 | 4783 | 2391.5 | 155.74 | 77.9 | Accurate and simple analytic representation of the electron-gas correlation energy. | Perdew, Wang | Phys Rev B Condens Matter | 1992 | 10001404 | Yes |
690 | 2387 | 2387.0 | 65.55 | 65.5 | Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. | H G Gratzner | Science | 1982 | 7123245 | Yes |
691 | 2386 | 2386.0 | 91.33 | 91.3 | What is value in health care? | Michael E Porter | N Engl J Med | 2010 | 21142528 | Yes |
692 | 2382 | 2382.0 | 70.59 | 70.6 | Formation and Structure of Self-Assembled Monolayers. | Abraham Ulman | Chem Rev | 1996 | 11848802 | Yes |
693 | 2382 | 2382.0 | 79.8 | 79.8 | Accelerated Profile HMM Searches. | Sean R Eddy | PLoS Comput Biol | 2011 | 22039361 | Yes |
694 | 4762 | 2381.0 | 97.77 | 48.9 | Untangling the ErbB signalling network. | Y Yarden, M X Sliwkowski | Nat Rev Mol Cell Biol | 2001 | 11252954 | No |
695 | 2380 | 2380.0 | 127.02 | 127.0 | Interrater reliability: the kappa statistic. | Mary L McHugh | Biochem Med (Zagreb) | 2012 | 23092060 | Yes |
696 | 9516 | 2379.0 | 480.29 | 120.1 | Cancer statistics, 2014. | Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin Jemal | CA Cancer J Clin | 2014 | 24399786 | Yes |
697 | 4757 | 2378.5 | 168.12 | 84.1 | Complex network measures of brain connectivity: uses and interpretations. | Mikail Rubinov, Olaf Sporns | Neuroimage | 2010 | 19819337 | Yes |
698 | 2374 | 2374.0 | 57.54 | 57.5 | Epigenetics in cancer. | Manel Esteller | N Engl J Med | 2008 | 18337604 | No |
699 | 4745 | 2372.5 | 120.25 | 60.1 | Autophagy in the pathogenesis of disease. | Beth Levine, Guido Kroemer | Cell | 2008 | 18191218 | No |
700 | 4744 | 2372.0 | 95.05 | 47.5 | CDK inhibitors: positive and negative regulators of G1-phase progression. | C J Sherr, J M Roberts | Genes Dev | 1999 | 10385618 | No |
701 | 4739 | 2369.5 | 0.0 | 0.0 | A general method applicable to the search for similarities in the amino acid sequence of two proteins. | S B Needleman, C D Wunsch | J Mol Biol | 1970 | 5420325 | Yes |
702 | 2369 | 2369.0 | 0.0 | 0.0 | Electroimmuno assay. | C B Laurell | Scand J Clin Lab Invest Suppl | 1972 | 4114358 | Yes |
703 | 2368 | 2368.0 | 56.8 | 56.8 | Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. | G P Smith | Science | 1985 | 4001944 | Yes |
704 | 2366 | 2366.0 | 61.32 | 61.3 | Cancer nanotechnology: opportunities and challenges. | Mauro Ferrari | Nat Rev Cancer | 2005 | 15738981 | No |
705 | 2365 | 2365.0 | 0.0 | 0.0 | A rapid radiochemical method for the determination of choline acetyltransferase. | F Fonnum | J Neurochem | 1975 | 1113118 | Yes |
706 | 2364 | 2364.0 | 54.75 | 54.8 | Salt and drought stress signal transduction in plants. | Jian-Kang Zhu | Annu Rev Plant Biol | 2002 | 12221975 | No |
707 | 7081 | 2360.3 | 2079.68 | 693.2 | Cancer statistics, 2020. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2020 | 31912902 | Yes |
708 | 2360 | 2360.0 | 97.16 | 97.2 | The Danish Civil Registration System. | Carsten Bøcker Pedersen | Scand J Public Health | 2011 | 21775345 | Yes |
709 | 4720 | 2360.0 | 237.11 | 118.6 | GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. | Rod Peakall, Peter E Smouse | Bioinformatics | 2012 | 22820204 | Yes |
710 | 2358 | 2358.0 | 0.0 | 0.0 | The glomerular permeability determined by dextran clearance using Sephadex gel filtration. | C E Mogensen | Scand J Clin Lab Invest | 1968 | 5637478 | Yes |
711 | 4716 | 2358.0 | 0.0 | 0.0 | Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. | J D Watson, F H Crick | Nature | 1953 | 13054692 | Yes |
712 | 2349 | 2349.0 | 46.2 | 46.2 | Getting started with yeast. | F Sherman | Methods Enzymol | 1991 | 2005794 | Yes |
713 | 4698 | 2349.0 | 101.23 | 50.6 | MicroRNAs: small RNAs with a big role in gene regulation. | Lin He, Gregory J Hannon | Nat Rev Genet | 2004 | 15211354 | No |
714 | 4693 | 2346.5 | 0.0 | 0.0 | Screening lambdagt recombinant clones by hybridization to single plaques in situ. | W D Benton, R W Davis | Science | 1977 | 322279 | Yes |
715 | 7018 | 2339.3 | 139.94 | 46.6 | Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. | Ron Edgar, Michael Domrachev, Alex E Lash | Nucleic Acids Res | 2002 | 11752295 | Yes |
716 | 4673 | 2336.5 | 0.0 | 0.0 | Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. | J Silness, H Loe | Acta Odontol Scand | 1964 | 14158464 | Yes |
717 | 4671 | 2335.5 | 121.73 | 60.9 | Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. | Weizhong Li, Adam Godzik | Bioinformatics | 2006 | 16731699 | Yes |
718 | 2335 | 2335.0 | 54.25 | 54.2 | Angiogenesis in life, disease and medicine. | Peter Carmeliet | Nature | 2005 | 16355210 | No |
719 | 4652 | 2326.0 | 0.0 | 0.0 | Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. | R A Laskey, A D Mills | Eur J Biochem | 1975 | 1175627 | Yes |
720 | 6969 | 2323.0 | 393.22 | 131.1 | Deep learning. | Yann LeCun, Yoshua Bengio, Geoffrey Hinton | Nature | 2015 | 26017442 | No |
721 | 2321 | 2321.0 | 51.57 | 51.6 | Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. | T Hunter | Cell | 1995 | 7834742 | No |
722 | 2320 | 2320.0 | 75.65 | 75.7 | adegenet: a R package for the multivariate analysis of genetic markers. | Thibaut Jombart | Bioinformatics | 2008 | 18397895 | Yes |
723 | 2317 | 2317.0 | 85.96 | 86.0 | Calmodulin plays a pivotal role in cellular regulation. | W Y Cheung | Science | 1980 | 6243188 | No |
724 | 2316 | 2316.0 | 50.74 | 50.7 | Evolving concepts of rheumatoid arthritis. | Gary S Firestein | Nature | 2003 | 12748655 | No |
725 | 2312 | 2312.0 | 0.0 | 0.0 | The Michigan alcoholism screening test: the quest for a new diagnostic instrument. | M L Selzer | Am J Psychiatry | 1971 | 5565851 | Yes |
726 | 2312 | 2312.0 | 0.0 | 0.0 | Application of a microtechnique to viral serological investigations. | J L Sever | J Immunol | 1962 | 13910995 | Yes |
727 | 4624 | 2312.0 | 177.87 | 88.9 | FLASH: fast length adjustment of short reads to improve genome assemblies. | Tanja Magoč, Steven L Salzberg | Bioinformatics | 2011 | 21903629 | Yes |
728 | 2311 | 2311.0 | 63.15 | 63.1 | The magical number 4 in short-term memory: a reconsideration of mental storage capacity. | N Cowan | Behav Brain Sci | 2001 | 11515286 | Yes |
729 | 2311 | 2311.0 | 132.19 | 132.2 | Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. | Daniël Lakens | Front Psychol | 2013 | 24324449 | No |
730 | 2308 | 2308.0 | 53.75 | 53.8 | A decade of molecular biology of retinoic acid receptors. | P Chambon | FASEB J | 1996 | 8801176 | No |
731 | 2307 | 2307.0 | 57.11 | 57.1 | MapChart: software for the graphical presentation of linkage maps and QTLs. | R E Voorrips | J Hered | 2002 | 12011185 | Yes |
732 | 2307 | 2307.0 | 56.75 | 56.8 | Calcium signaling. | David E Clapham | Cell | 2007 | 18083096 | No |
733 | 2306 | 2306.0 | 96.78 | 96.8 | Qualitative research. Introducing focus groups. | J Kitzinger | BMJ | 1995 | 7633241 | Yes |
734 | 2299 | 2299.0 | 0.0 | 0.0 | Separation of leukocytes from blood and bone marrow. Introduction. | A Böyum | Scand J Clin Lab Invest Suppl | 1968 | 5707208 | Yes |
735 | 2298 | 2298.0 | 51.91 | 51.9 | The structure and regulation of protein phosphatases. | P Cohen | Annu Rev Biochem | 1989 | 2549856 | No |
736 | 2297 | 2297.0 | 67.15 | 67.2 | Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. | P Correa | Cancer Res | 1992 | 1458460 | No |
737 | 2296 | 2296.0 | 0.0 | 0.0 | Inositol phospholipids and cell surface receptor function. | R H Michell | Biochim Biophys Acta | 1975 | 164246 | No |
738 | 4592 | 2296.0 | 104.61 | 52.3 | Death receptors: signaling and modulation. | A Ashkenazi, V M Dixit | Science | 1998 | 9721089 | No |
739 | 2293 | 2293.0 | 66.5 | 66.5 | Interleukin-1 and interleukin-1 antagonism. | C A Dinarello | Blood | 1991 | 1826616 | No |
740 | 2290 | 2290.0 | 57.6 | 57.6 | Bcl-2 and the regulation of programmed cell death. | J C Reed | J Cell Biol | 1994 | 8294493 | No |
741 | 2289 | 2289.0 | 47.72 | 47.7 | Tumour-educated macrophages promote tumour progression and metastasis. | Jeffrey W Pollard | Nat Rev Cancer | 2004 | 14708027 | No |
742 | 4575 | 2287.5 | 228.68 | 114.3 | phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. | Paul J McMurdie, Susan Holmes | PLoS One | 2013 | 23630581 | Yes |
743 | 4566 | 2283.0 | 143.21 | 71.6 | Rapid isolation of high molecular weight plant DNA. | M G Murray, W F Thompson | Nucleic Acids Res | 1980 | 7433111 | Yes |
744 | 2282 | 2282.0 | 0.0 | 0.0 | Muscle structure and theories of contraction. | A F Huxley | Prog Biophys Biophys Chem | 1957 | 13485191 | Yes |
745 | 4561 | 2280.5 | 0.0 | 0.0 | High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. | M N Berry, D S Friend | J Cell Biol | 1969 | 4900611 | Yes |
746 | 4556 | 2278.0 | 94.77 | 47.4 | Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. | D Bonnet, J E Dick | Nat Med | 1997 | 9212098 | Yes |
747 | 2270 | 2270.0 | 45.73 | 45.7 | SV40-transformed simian cells support the replication of early SV40 mutants. | Y Gluzman | Cell | 1981 | 6260373 | Yes |
748 | 6805 | 2268.3 | 374.8 | 124.9 | Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. | P J Van Soest, J B Robertson, B A Lewis | J Dairy Sci | 1991 | 1660498 | No |
749 | 4535 | 2267.5 | 91.67 | 45.8 | The phosphatidylinositol 3-Kinase AKT pathway in human cancer. | Igor Vivanco, Charles L Sawyers | Nat Rev Cancer | 2002 | 12094235 | No |
750 | 2267 | 2267.0 | 0.0 | 0.0 | Stereochemistry of cooperative effects in haemoglobin. | M F Perutz | Nature | 1970 | 5528785 | Yes |
751 | 2263 | 2263.0 | 0.0 | 0.0 | Evaluating the quality of medical care. | A Donabedian | Milbank Mem Fund Q | 1966 | 5338568 | No |
752 | 6786 | 2262.0 | 0.0 | 0.0 | On The Nature Of Allosteric Transitions: A Plausible Model. | J Monod, J Wyman, J P Changeux | J Mol Biol | 1965 | 14343300 | Yes |
753 | 2258 | 2258.0 | 76.51 | 76.5 | Glutamate, nitric oxide and cell-cell signalling in the nervous system. | J Garthwaite | Trends Neurosci | 1991 | 1708538 | No |
754 | 4503 | 2251.5 | 92.09 | 46.0 | Lipid rafts and signal transduction. | K Simons, D Toomre | Nat Rev Mol Cell Biol | 2000 | 11413487 | No |
755 | 2250 | 2250.0 | 71.3 | 71.3 | SF-36 health survey update. | J E Ware | Spine (Phila Pa 1976) | 2000 | 11124729 | No |
756 | 2249 | 2249.0 | 51.65 | 51.6 | Mitochondrial diseases in man and mouse. | D C Wallace | Science | 1999 | 10066162 | No |
757 | 2248 | 2248.0 | 67.99 | 68.0 | A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. | Heng Li | Bioinformatics | 2011 | 21903627 | Yes |
758 | 2247 | 2247.0 | 67.09 | 67.1 | Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. | M Leavitt | MedGenMed | 2001 | 11549951 | No |
759 | 4494 | 2247.0 | 123.07 | 61.5 | Management of hepatocellular carcinoma. | Jordi Bruix, Morris Sherman | Hepatology | 2005 | 16250051 | No |
760 | 4488 | 2244.0 | 103.57 | 51.8 | A simple and very efficient method for generating cDNA libraries. | U Gubler, B J Hoffman | Gene | 1983 | 6198242 | Yes |
761 | 2242 | 2242.0 | 58.6 | 58.6 | Causes and consequences of microRNA dysregulation in cancer. | Carlo M Croce | Nat Rev Genet | 2009 | 19763153 | No |
762 | 4477 | 2238.5 | 85.55 | 42.8 | A novel genetic system to detect protein-protein interactions. | S Fields, O Song | Nature | 1989 | 2547163 | Yes |
763 | 2236 | 2236.0 | 56.44 | 56.4 | A model for receptor-regulated calcium entry. | J W Putney | Cell Calcium | 1986 | 2420465 | No |
764 | 2236 | 2236.0 | 0.0 | 0.0 | The information capacity of the human motor system in controlling the amplitude of movement. | P M Fitts | J Exp Psychol | 1954 | 13174710 | Yes |
765 | 2232 | 2232.0 | 59.5 | 59.5 | A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. | P Chomczynski | Biotechniques | 1993 | 7692896 | Yes |
766 | 2229 | 2229.0 | 57.14 | 57.1 | Molecular basis of bacterial outer membrane permeability revisited. | Hiroshi Nikaido | Microbiol Mol Biol Rev | 2003 | 14665678 | No |
767 | 2229 | 2229.0 | 80.84 | 80.8 | A computational approach to edge detection. | J Canny | IEEE Trans Pattern Anal Mach Intell | 1986 | 21869365 | Yes |
768 | 2228 | 2228.0 | 0.0 | 0.0 | A Rationale And Test For The Number Of Factors In Factor Analysis. | J L Horn | Psychometrika | 1965 | 14306381 | Yes |
769 | 4451 | 2225.5 | 222.97 | 111.5 | Stress, social support, and the buffering hypothesis. | S Cohen, T A Wills | Psychol Bull | 1985 | 3901065 | No |
770 | 2225 | 2225.0 | 71.4 | 71.4 | Reactive oxygen species and the central nervous system. | B Halliwell | J Neurochem | 1992 | 1402908 | No |
771 | 2225 | 2225.0 | 49.3 | 49.3 | Molecular physiology of P2X receptors. | R Alan North | Physiol Rev | 2002 | 12270951 | No |
772 | 4447 | 2223.5 | 129.67 | 64.8 | Pattern recognition receptors and inflammation. | Osamu Takeuchi, Shizuo Akira | Cell | 2010 | 20303872 | No |
773 | 2223 | 2223.0 | 55.33 | 55.3 | Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. | J Kyhse-Andersen | J Biochem Biophys Methods | 1984 | 6530509 | Yes |
774 | 2223 | 2223.0 | 59.51 | 59.5 | Dietary pattern analysis: a new direction in nutritional epidemiology. | Frank B Hu | Curr Opin Lipidol | 2002 | 11790957 | No |
775 | 2221 | 2221.0 | 53.43 | 53.4 | Mechanisms and genes of cellular suicide. | H Steller | Science | 1995 | 7878463 | No |
776 | 2219 | 2219.0 | 0.0 | 0.0 | Mechanisms of action of transmitters and other substances on smooth muscle. | T B Bolton | Physiol Rev | 1979 | 37533 | No |
777 | 4438 | 2219.0 | 99.77 | 49.9 | Organization and expression of eucaryotic split genes coding for proteins. | R Breathnach, P Chambon | Annu Rev Biochem | 1981 | 6791577 | No |
778 | 2219 | 2219.0 | 50.09 | 50.1 | Chemokines and leukocyte traffic. | M Baggiolini | Nature | 1998 | 9560152 | No |
779 | 4431 | 2215.5 | 119.98 | 60.0 | Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. | Marie-Christine Daniel, Didier Astruc | Chem Rev | 2004 | 14719978 | No |
780 | 2214 | 2214.0 | 62.01 | 62.0 | Molecular diversity of glutamate receptors and implications for brain function. | S Nakanishi | Science | 1992 | 1329206 | No |
781 | 8845 | 2211.2 | 286.17 | 71.5 | Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. | Qiong Wang, George M Garrity, James M Tiedje, James R Cole | Appl Environ Microbiol | 2007 | 17586664 | Yes |
782 | 2211 | 2211.0 | 0.0 | 0.0 | Removal of fatty acids from serum albumin by charcoal treatment. | R F Chen | J Biol Chem | 1967 | 6016603 | Yes |
783 | 4419 | 2209.5 | 0.0 | 0.0 | On the size of the active site in proteases. I. Papain. | I Schechter, A Berger | Biochem Biophys Res Commun | 1967 | 6035483 | Yes |
784 | 2209 | 2209.0 | 53.48 | 53.5 | Protein kinase C and lipid signaling for sustained cellular responses. | Y Nishizuka | FASEB J | 1995 | 7737456 | No |
785 | 4417 | 2208.5 | 0.0 | 0.0 | The interpretation of protein structures: estimation of static accessibility. | B Lee, F M Richards | J Mol Biol | 1971 | 5551392 | Yes |
786 | 2207 | 2207.0 | 85.56 | 85.6 | Role of endothelium in responses of vascular smooth muscle. | R F Furchgott | Circ Res | 1983 | 6313250 | No |
787 | 2205 | 2205.0 | 78.73 | 78.7 | Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. | B N Ames | Science | 1983 | 6351251 | No |
788 | 2204 | 2204.0 | 0.0 | 0.0 | [Rapid physiological coagulation method in determination of fibrinogen]. | A Clauss | Acta Haematol | 1957 | 13434757 | Yes |
789 | 4406 | 2203.0 | 0.0 | 0.0 | Periodontal Disease In Pregnancy. I. Prevalence And Severity. | H Loe, J Silness | Acta Odontol Scand | 1963 | 14121956 | Yes |
790 | 4402 | 2201.0 | 115.95 | 58.0 | A receptor-mediated pathway for cholesterol homeostasis. | M S Brown, J L Goldstein | Science | 1986 | 3513311 | No |
791 | 2201 | 2201.0 | 65.75 | 65.8 | Two-sided confidence intervals for the single proportion: comparison of seven methods. | R G Newcombe | Stat Med | 1998 | 9595616 | Yes |
792 | 4397 | 2198.5 | 96.15 | 48.1 | New functions for the matrix metalloproteinases in cancer progression. | Mikala Egeblad, Zena Werb | Nat Rev Cancer | 2002 | 11990853 | No |
793 | 4395 | 2197.5 | 0.0 | 0.0 | The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. | J A Spudich, S Watt | J Biol Chem | 1971 | 4254541 | Yes |
794 | 13184 | 2197.3 | 321.75 | 53.6 | Phaser crystallographic software. | Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J Read | J Appl Crystallogr | 2007 | 19461840 | Yes |
795 | 2196 | 2196.0 | 55.12 | 55.1 | Modularity and community structure in networks. | M E J Newman | Proc Natl Acad Sci U S A | 2006 | 16723398 | Yes |
796 | 2190 | 2190.0 | 68.34 | 68.3 | Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. | R A DeFronzo | Diabetes | 1988 | 3289989 | No |
797 | 4379 | 2189.5 | 0.0 | 0.0 | A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. | J E TILL, E A McCULLOCH | Radiat Res | 1961 | 13776896 | Yes |
798 | 4378 | 2189.0 | 148.71 | 74.4 | Random-effects models for longitudinal data. | N M Laird, J H Ware | Biometrics | 1982 | 7168798 | Yes |
799 | 2183 | 2183.0 | 53.99 | 54.0 | Ischemic cell death in brain neurons. | P Lipton | Physiol Rev | 1999 | 10508238 | No |
800 | 2182 | 2182.0 | 68.21 | 68.2 | Prooxidant states and tumor promotion. | P A Cerutti | Science | 1985 | 2981433 | No |
801 | 2180 | 2180.0 | 47.37 | 47.4 | Telomere measurement by quantitative PCR. | Richard M Cawthon | Nucleic Acids Res | 2002 | 12000852 | Yes |
802 | 2177 | 2177.0 | 42.25 | 42.2 | Java Treeview--extensible visualization of microarray data. | Alok J Saldanha | Bioinformatics | 2004 | 15180930 | Yes |
803 | 2175 | 2175.0 | 71.13 | 71.1 | Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. | Peter C Austin | Stat Med | 2009 | 19757444 | Yes |
804 | 2168 | 2168.0 | 48.6 | 48.6 | The regulation of AP-1 activity by mitogen-activated protein kinases. | M Karin | J Biol Chem | 1995 | 7622446 | No |
805 | 4335 | 2167.5 | 132.39 | 66.2 | Neural mechanisms of selective visual attention. | R Desimone, J Duncan | Annu Rev Neurosci | 1995 | 7605061 | No |
806 | 6494 | 2164.7 | 294.77 | 98.3 | Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. | J L Cox, J M Holden, R Sagovsky | Br J Psychiatry | 1987 | 3651732 | Yes |
807 | 4329 | 2164.5 | 128.5 | 64.2 | Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9167458 | Yes |
808 | 4329 | 2164.5 | 153.43 | 76.7 | The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. | S H Downs, N Black | J Epidemiol Community Health | 1998 | 9764259 | Yes |
809 | 6493 | 2164.3 | 151.48 | 50.5 | The biology of VEGF and its receptors. | Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter | Nat Med | 2003 | 12778165 | No |
810 | 2163 | 2163.0 | 86.72 | 86.7 | Effective physician-patient communication and health outcomes: a review. | M A Stewart | CMAJ | 1995 | 7728691 | Yes |
811 | 2162 | 2162.0 | 79.67 | 79.7 | DNA methylation age of human tissues and cell types. | Steve Horvath | Genome Biol | 2013 | 24138928 | Yes |
812 | 2157 | 2157.0 | 66.13 | 66.1 | Diagnosis of Alzheimer's disease. | Z S Khachaturian | Arch Neurol | 1985 | 2864910 | Yes |
813 | 2155 | 2155.0 | 0.0 | 0.0 | Sedimentation Studies Of The Size And Shape Of Dna. | F W Studier | J Mol Biol | 1965 | 14290352 | Yes |
814 | 6463 | 2154.3 | 208.08 | 69.4 | Arlequin (version 3.0): an integrated software package for population genetics data analysis. | Laurent Excoffier, Guillaume Laval, Stefan Schneider | Evol Bioinform Online | 2007 | 19325852 | Yes |
815 | 2154 | 2154.0 | 79.88 | 79.9 | Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. | H W Steinbusch | Neuroscience | 1981 | 7017455 | Yes |
816 | 2154 | 2154.0 | 49.06 | 49.1 | Chemokines. | B J Rollins | Blood | 1997 | 9242519 | No |
817 | 4306 | 2153.0 | 118.25 | 59.1 | Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. | C W Elston, I O Ellis | Histopathology | 1991 | 1757079 | Yes |
818 | 2150 | 2150.0 | 53.81 | 53.8 | The anatomy and taxonomy of protein structure. | J S Richardson | Adv Protein Chem | 1981 | 7020376 | No |
819 | 4298 | 2149.0 | 96.15 | 48.1 | Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. | F Sallusto, A Lanzavecchia | J Exp Med | 1994 | 8145033 | Yes |
820 | 2149 | 2149.0 | 41.44 | 41.4 | Histone acetylation in chromatin structure and transcription. | M Grunstein | Nature | 1997 | 9311776 | No |
821 | 4298 | 2149.0 | 99.74 | 49.9 | The Bcl-2 protein family: arbiters of cell survival. | J M Adams, S Cory | Science | 1998 | 9735050 | No |
822 | 4294 | 2147.0 | 196.04 | 98.0 | Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. | N S Jacobson, P Truax | J Consult Clin Psychol | 1991 | 2002127 | Yes |
823 | 2147 | 2147.0 | 49.8 | 49.8 | A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. | Douglas C Wallace | Annu Rev Genet | 2005 | 16285865 | No |
824 | 2147 | 2147.0 | 64.61 | 64.6 | Physiology and neurobiology of stress and adaptation: central role of the brain. | Bruce S McEwen | Physiol Rev | 2007 | 17615391 | No |
825 | 2147 | 2147.0 | 0.0 | 0.0 | A new specific color reaction of hexuronic acids. | Z Dische | J Biol Chem | 1947 | 20281638 | Yes |
826 | 4293 | 2146.5 | 103.24 | 51.6 | Signal integration in the endoplasmic reticulum unfolded protein response. | David Ron, Peter Walter | Nat Rev Mol Cell Biol | 2007 | 17565364 | No |
827 | 6439 | 2146.3 | 191.21 | 63.7 | Bacterial biofilms: a common cause of persistent infections. | J W Costerton, P S Stewart, E P Greenberg | Science | 1999 | 10334980 | No |
828 | 2146 | 2146.0 | 41.42 | 41.4 | Targeting RAS signalling pathways in cancer therapy. | Julian Downward | Nat Rev Cancer | 2003 | 12509763 | No |
829 | 2146 | 2146.0 | 0.0 | 0.0 | The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. | W W Cleland | Biochim Biophys Acta | 1963 | 14021667 | Yes |
830 | 2141 | 2141.0 | 64.09 | 64.1 | Scaffolds in tissue engineering bone and cartilage. | D W Hutmacher | Biomaterials | 2000 | 11071603 | Yes |
831 | 4275 | 2137.5 | 0.0 | 0.0 | The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. | H P Misra, I Fridovich | J Biol Chem | 1972 | 4623845 | Yes |
832 | 2137 | 2137.0 | 0.0 | 0.0 | Intracellular aspects of the process of protein synthesis. | G Palade | Science | 1975 | 1096303 | No |
833 | 8533 | 2133.2 | 246.77 | 61.7 | GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. | Berk Hess, Carsten Kutzner, David van der Spoel, Erik Lindahl | J Chem Theory Comput | 2008 | 26620784 | Yes |
834 | 4257 | 2128.5 | 0.0 | 0.0 | A Simplified Lead Citrate Stain For Use In Electron Microscopy. | J H Venable, R Coggeshall | J Cell Biol | 1965 | 14287192 | Yes |
835 | 2127 | 2127.0 | 0.0 | 0.0 | The plasma lecithins:cholesterol acyltransferase reaction. | J A Glomset | J Lipid Res | 1968 | 4868699 | No |
836 | 2126 | 2126.0 | 42.02 | 42.0 | Protein modules and signalling networks. | T Pawson | Nature | 1995 | 7531822 | No |
837 | 4249 | 2124.5 | 94.89 | 47.4 | Mass spectrometry-based proteomics. | Ruedi Aebersold, Matthias Mann | Nature | 2003 | 12634793 | No |
838 | 2121 | 2121.0 | 80.49 | 80.5 | Specific impairments of planning. | T Shallice | Philos Trans R Soc Lond B Biol Sci | 1982 | 6125971 | Yes |
839 | 4236 | 2118.0 | 86.4 | 43.2 | Mechanisms of TGF-beta signaling from cell membrane to the nucleus. | Yigong Shi, Joan Massagué | Cell | 2003 | 12809600 | No |
840 | 2118 | 2118.0 | 54.87 | 54.9 | A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. | Pascal Fries | Trends Cogn Sci | 2005 | 16150631 | No |
841 | 4233 | 2116.5 | 105.88 | 52.9 | Regulation of the mevalonate pathway. | J L Goldstein, M S Brown | Nature | 1990 | 1967820 | No |
842 | 4229 | 2114.5 | 156.2 | 78.1 | The attention system of the human brain. | M I Posner, S E Petersen | Annu Rev Neurosci | 1990 | 2183676 | No |
843 | 2113 | 2113.0 | 50.54 | 50.5 | Specification of cerebral cortical areas. | P Rakic | Science | 1988 | 3291116 | No |
844 | 2113 | 2113.0 | 0.0 | 0.0 | Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. | D Aminoff | Biochem J | 1961 | 13860975 | Yes |
845 | 2112 | 2112.0 | 47.12 | 47.1 | NOX enzymes and the biology of reactive oxygen. | J David Lambeth | Nat Rev Immunol | 2004 | 15039755 | No |
846 | 4221 | 2110.5 | 101.1 | 50.5 | Assembly of asparagine-linked oligosaccharides. | R Kornfeld, S Kornfeld | Annu Rev Biochem | 1985 | 3896128 | No |
847 | 2110 | 2110.0 | 43.56 | 43.6 | The molecular biology of memory storage: a dialogue between genes and synapses. | E R Kandel | Science | 2001 | 11691980 | No |
848 | 2108 | 2108.0 | 88.82 | 88.8 | A systematic method for clinical description and classification of personality variants. A proposal. | C R Cloninger | Arch Gen Psychiatry | 1987 | 3579504 | Yes |
849 | 4216 | 2108.0 | 107.37 | 53.7 | Function and activation of NF-kappa B in the immune system. | P A Baeuerle, T Henkel | Annu Rev Immunol | 1994 | 8011280 | No |
850 | 4215 | 2107.5 | 0.0 | 0.0 | Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. | R B Devereux, N Reichek | Circulation | 1977 | 138494 | Yes |
851 | 4209 | 2104.5 | 110.03 | 55.0 | Reactive oxygen species: metabolism, oxidative stress, and signal transduction. | Klaus Apel, Heribert Hirt | Annu Rev Plant Biol | 2004 | 15377225 | No |
852 | 2103 | 2103.0 | 50.31 | 50.3 | Patterns of amino acids near signal-sequence cleavage sites. | G von Heijne | Eur J Biochem | 1983 | 6852022 | Yes |
853 | 4202 | 2101.0 | 0.0 | 0.0 | Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. | T V Bliss, T Lomo | J Physiol | 1973 | 4727084 | Yes |
854 | 2101 | 2101.0 | 0.0 | 0.0 | The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. | D E Atkinson | Biochemistry | 1968 | 4972613 | Yes |
855 | 2101 | 2101.0 | 58.09 | 58.1 | Immunological and inflammatory functions of the interleukin-1 family. | Charles A Dinarello | Annu Rev Immunol | 2009 | 19302047 | No |
856 | 4201 | 2100.5 | 123.05 | 61.5 | Distributed hierarchical processing in the primate cerebral cortex. | D J Felleman, D C Van Essen | Cereb Cortex | 1991 | 1822724 | No |
857 | 2100 | 2100.0 | 46.52 | 46.5 | Cisplatin: mode of cytotoxic action and molecular basis of resistance. | Zahid H Siddik | Oncogene | 2003 | 14576837 | No |
858 | 2099 | 2099.0 | 65.17 | 65.2 | Parkinson's disease: clinical features and diagnosis. | J Jankovic | J Neurol Neurosurg Psychiatry | 2008 | 18344392 | No |
859 | 6297 | 2099.0 | 174.07 | 58.0 | RNA-Seq: a revolutionary tool for transcriptomics. | Zhong Wang, Mark Gerstein, Michael Snyder | Nat Rev Genet | 2009 | 19015660 | No |
860 | 2096 | 2096.0 | 49.35 | 49.4 | Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. | G Trinchieri | Annu Rev Immunol | 1995 | 7612223 | No |
861 | 2095 | 2095.0 | 0.0 | 0.0 | Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. | F F Jöbsis | Science | 1977 | 929199 | Yes |
862 | 16747 | 2093.4 | 543.79 | 68.0 | The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. | D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C Siebert | N Engl J Med | 1993 | 8366922 | Yes |
863 | 4183 | 2091.5 | 138.2 | 69.1 | Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. | R M Ryan, E L Deci | Am Psychol | 2000 | 11392867 | Yes |
864 | 4175 | 2087.5 | 121.07 | 60.5 | Angiogenic factors. | J Folkman, M Klagsbrun | Science | 1987 | 2432664 | No |
865 | 4175 | 2087.5 | 159.53 | 79.8 | Self-rated health and mortality: a review of twenty-seven community studies. | E L Idler, Y Benyamini | J Health Soc Behav | 1997 | 9097506 | No |
866 | 2086 | 2086.0 | 44.69 | 44.7 | Mammalian G1 cyclins. | C J Sherr | Cell | 1993 | 8513492 | No |
867 | 4167 | 2083.5 | 123.17 | 61.6 | Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. | J S Beckman, W H Koppenol | Am J Physiol | 1996 | 8944624 | No |
868 | 6249 | 2083.0 | 0.0 | 0.0 | Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. | B N Ames, J Mccann, E Yamasaki | Mutat Res | 1975 | 768755 | Yes |
869 | 6247 | 2082.3 | 170.47 | 56.8 | ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. | Kai Wang, Mingyao Li, Hakon Hakonarson | Nucleic Acids Res | 2010 | 20601685 | Yes |
870 | 2082 | 2082.0 | 62.64 | 62.6 | Stress, adaptation, and disease. Allostasis and allostatic load. | B S McEwen | Ann N Y Acad Sci | 1998 | 9629234 | No |
871 | 2082 | 2082.0 | 0.0 | 0.0 | Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. | T Higuchi | J Pharm Sci | 1963 | 14088963 | Yes |
872 | 6240 | 2080.0 | 146.21 | 48.7 | MOLMOL: a program for display and analysis of macromolecular structures. | R Koradi, M Billeter, K Wüthrich | J Mol Graph | 1996 | 8744573 | Yes |
873 | 4158 | 2079.0 | 107.56 | 53.8 | Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. | E Lander, L Kruglyak | Nat Genet | 1995 | 7581446 | Yes |
874 | 2079 | 2079.0 | 64.72 | 64.7 | Efficient methods to compute genomic predictions. | P M VanRaden | J Dairy Sci | 2008 | 18946147 | Yes |
875 | 2077 | 2077.0 | 0.0 | 0.0 | Method For Assay Of Intestinal Disaccharidases. | A Dahlqvist | Anal Biochem | 1964 | 14106916 | Yes |
876 | 4149 | 2074.5 | 99.12 | 49.6 | AKT/PKB signaling: navigating downstream. | Brendan D Manning, Lewis C Cantley | Cell | 2007 | 17604717 | No |
877 | 4148 | 2074.0 | 129.17 | 64.6 | Missing data: our view of the state of the art. | Joseph L Schafer, John W Graham | Psychol Methods | 2002 | 12090408 | Yes |
878 | 4146 | 2073.0 | 104.4 | 52.2 | Protein misfolding, functional amyloid, and human disease. | Fabrizio Chiti, Christopher M Dobson | Annu Rev Biochem | 2006 | 16756495 | No |
879 | 2072 | 2072.0 | 63.7 | 63.7 | The unbiased estimation of number and sizes of arbitrary particles using the disector. | D C Sterio | J Microsc | 1984 | 6737468 | Yes |
880 | 2068 | 2068.0 | 53.63 | 53.6 | Breast cancer and hormone-replacement therapy in the Million Women Study. | Valerie Beral | Lancet | 2003 | 12927427 | Yes |
881 | 4134 | 2067.0 | 108.45 | 54.2 | Acute-phase proteins and other systemic responses to inflammation. | C Gabay, I Kushner | N Engl J Med | 1999 | 9971870 | No |
882 | 4127 | 2063.5 | 107.33 | 53.7 | A global optimisation method for robust affine registration of brain images. | M Jenkinson, S Smith | Med Image Anal | 2001 | 11516708 | Yes |
883 | 2063 | 2063.0 | 0.0 | 0.0 | Isolation by Distance. | S Wright | Genetics | 1943 | 17247074 | Yes |
884 | 6188 | 2062.7 | 181.99 | 60.7 | Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. | C E Murry, R B Jennings, K A Reimer | Circulation | 1986 | 3769170 | Yes |
885 | 6188 | 2062.7 | 181.64 | 60.5 | Quantum mechanical continuum solvation models. | Jacopo Tomasi, Benedetta Mennucci, Roberto Cammi | Chem Rev | 2005 | 16092826 | Yes |
886 | 2062 | 2062.0 | 0.0 | 0.0 | Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. | J W Littlefield | Science | 1964 | 14168277 | Yes |
887 | 2060 | 2060.0 | 0.0 | 0.0 | Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. | J C Skou | Physiol Rev | 1965 | 14337569 | No |
888 | 4115 | 2057.5 | 87.78 | 43.9 | A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. | G Shaw, R Kamen | Cell | 1986 | 3488815 | Yes |
889 | 2052 | 2052.0 | 96.31 | 96.3 | Structural Model Evaluation and Modification: An Interval Estimation Approach. | J H Steiger | Multivariate Behav Res | 1990 | 26794479 | Yes |
890 | 4103 | 2051.5 | 0.0 | 0.0 | Plaque formation and isolation of pure lines with poliomyelitis viruses. | R Dulbecco, M Vogt | J Exp Med | 1954 | 13130792 | Yes |
891 | 2050 | 2050.0 | 0.0 | 0.0 | Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. | P Mitchell | Biol Rev Camb Philos Soc | 1966 | 5329743 | No |
892 | 2050 | 2050.0 | 52.55 | 52.5 | RGD and other recognition sequences for integrins. | E Ruoslahti | Annu Rev Cell Dev Biol | 1996 | 8970741 | No |
893 | 4099 | 2049.5 | 111.08 | 55.5 | The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. | Karen Bedard, Karl-Heinz Krause | Physiol Rev | 2007 | 17237347 | No |
894 | 4094 | 2047.0 | 106.28 | 53.1 | Myeloid-derived suppressor cells as regulators of the immune system. | Dmitry I Gabrilovich, Srinivas Nagaraj | Nat Rev Immunol | 2009 | 19197294 | No |
895 | 6135 | 2045.0 | 0.0 | 0.0 | Immunochemical quantitation of antigens by single radial immunodiffusion. | G Mancini, A O Carbonara, J F Heremans | Immunochemistry | 1965 | 4956917 | Yes |
896 | 2044 | 2044.0 | 69.02 | 69.0 | Working memory. | A Baddeley | Science | 1992 | 1736359 | No |
897 | 2044 | 2044.0 | 69.6 | 69.6 | A classification of glycosyl hydrolases based on amino acid sequence similarities. | B Henrissat | Biochem J | 1991 | 1747104 | Yes |
898 | 4083 | 2041.5 | 129.23 | 64.6 | SPSS and SAS procedures for estimating indirect effects in simple mediation models. | Kristopher J Preacher, Andrew F Hayes | Behav Res Methods Instrum Comput | 2004 | 15641418 | Yes |
899 | 2040 | 2040.0 | 42.98 | 43.0 | G1 events and regulation of cell proliferation. | A B Pardee | Science | 1989 | 2683075 | No |
900 | 2038 | 2038.0 | 45.93 | 45.9 | Nitric oxide and the immune response. | C Bogdan | Nat Immunol | 2001 | 11577346 | No |
901 | 4066 | 2033.0 | 81.49 | 40.7 | The fundamental role of epigenetic events in cancer. | Peter A Jones, Stephen B Baylin | Nat Rev Genet | 2002 | 12042769 | No |
902 | 6095 | 2031.7 | 0.0 | 0.0 | Glucose clamp technique: a method for quantifying insulin secretion and resistance. | R A DeFronzo, J D Tobin, R Andres | Am J Physiol | 1979 | 382871 | Yes |
903 | 2031 | 2031.0 | 57.68 | 57.7 | Superoxide radical and superoxide dismutases. | I Fridovich | Annu Rev Biochem | 1995 | 7574505 | No |
904 | 4057 | 2028.5 | 100.24 | 50.1 | Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. | P Liang, A B Pardee | Science | 1992 | 1354393 | Yes |
905 | 2028 | 2028.0 | 59.81 | 59.8 | ATP-regulated K+ channels in cardiac muscle. | A Noma | Nature | 1983 | 6310409 | Yes |
906 | 2027 | 2027.0 | 83.09 | 83.1 | A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. | E L Bradley | Arch Surg | 1993 | 8489394 | No |
907 | 2022 | 2022.0 | 67.26 | 67.3 | Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. | W A Craig | Clin Infect Dis | 1998 | 9455502 | No |
908 | 2022 | 2022.0 | 48.62 | 48.6 | The inflammatory reflex. | Kevin J Tracey | Nature | 2002 | 12490958 | No |
909 | 2022 | 2022.0 | 67.54 | 67.5 | Biodiesel from microalgae. | Yusuf Chisti | Biotechnol Adv | 2007 | 17350212 | No |
910 | 2021 | 2021.0 | 48.16 | 48.2 | Interleukin-2: inception, impact, and implications. | K A Smith | Science | 1988 | 3131876 | No |
911 | 2021 | 2021.0 | 42.96 | 43.0 | Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. | Shimon Sakaguchi | Nat Immunol | 2005 | 15785760 | No |
912 | 2021 | 2021.0 | 0.0 | 0.0 | Antigen-antibody reactions in gels. | O Ouchterlony | Acta Pathol Microbiol Scand | 1949 | 18143039 | Yes |
913 | 2021 | 2021.0 | 69.05 | 69.0 | Ethical authorship and publishing. | Andrew J S Coats | Int J Cardiol | 2009 | 19046787 | No |
914 | 2021 | 2021.0 | 91.12 | 91.1 | Central sensitization: implications for the diagnosis and treatment of pain. | Clifford J Woolf | Pain | 2011 | 20961685 | No |
915 | 2020 | 2020.0 | 0.0 | 0.0 | Analysis of bacteriophage T7 early RNAs and proteins on slab gels. | F W Studier | J Mol Biol | 1973 | 4760132 | Yes |
916 | 2018 | 2018.0 | 45.59 | 45.6 | Complement. First of two parts. | M J Walport | N Engl J Med | 2001 | 11287977 | No |
917 | 2017 | 2017.0 | 0.0 | 0.0 | Presidential Address-1976. Social support as a moderator of life stress. | S Cobb | Psychosom Med | 1976 | 981490 | Yes |
918 | 2007 | 2007.0 | 44.62 | 44.6 | Structural design and molecular evolution of a cytokine receptor superfamily. | J F Bazan | Proc Natl Acad Sci U S A | 1990 | 2169613 | Yes |
919 | 4014 | 2007.0 | 117.95 | 59.0 | Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. | Michael D Fox, Marcus E Raichle | Nat Rev Neurosci | 2007 | 17704812 | No |
920 | 2006 | 2006.0 | 83.31 | 83.3 | Role of Streptococcus mutans in human dental decay. | W J Loesche | Microbiol Rev | 1986 | 3540569 | No |
921 | 2006 | 2006.0 | 0.0 | 0.0 | Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. | G Bertani | J Bacteriol | 1951 | 14888646 | Yes |
922 | 2006 | 2006.0 | 62.35 | 62.4 | Hybrid porous solids: past, present, future. | Gérard Férey | Chem Soc Rev | 2008 | 18197340 | Yes |
923 | 2005 | 2005.0 | 59.86 | 59.9 | The nuclear factor NF-kappaB pathway in inflammation. | Toby Lawrence | Cold Spring Harb Perspect Biol | 2009 | 20457564 | No |
924 | 4009 | 2004.5 | 0.0 | 0.0 | Loss of recent memory after bilateral hippocampal lesions. | W B Scoville, B Milner | J Neurol Neurosurg Psychiatry | 1957 | 13406589 | Yes |
925 | 2003 | 2003.0 | 47.9 | 47.9 | Calcium signaling. | D E Clapham | Cell | 1995 | 7834745 | No |
926 | 2002 | 2002.0 | 53.86 | 53.9 | The molecular pathology of Alzheimer's disease. | D J Selkoe | Neuron | 1991 | 1673054 | No |
927 | 3999 | 1999.5 | 113.47 | 56.7 | A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. | Y Matsumura, H Maeda | Cancer Res | 1986 | 2946403 | Yes |
928 | 3997 | 1998.5 | 80.69 | 40.3 | Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. | M Gossen, H Bujard | Proc Natl Acad Sci U S A | 1992 | 1319065 | Yes |
929 | 1996 | 1996.0 | 53.0 | 53.0 | The heme oxygenase system: a regulator of second messenger gases. | M D Maines | Annu Rev Pharmacol Toxicol | 1997 | 9131263 | No |
930 | 1996 | 1996.0 | 42.69 | 42.7 | XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. | D E McRee | J Struct Biol | 1999 | 10222271 | Yes |
931 | 1996 | 1996.0 | 56.05 | 56.0 | The importance of selenium to human health. | M P Rayman | Lancet | 2000 | 10963212 | No |
932 | 3989 | 1994.5 | 109.44 | 54.7 | New perspectives in cell adhesion: RGD and integrins. | E Ruoslahti, M D Pierschbacher | Science | 1987 | 2821619 | No |
933 | 1994 | 1994.0 | 39.88 | 39.9 | Shelterin: the protein complex that shapes and safeguards human telomeres. | Titia de Lange | Genes Dev | 2005 | 16166375 | No |
934 | 1994 | 1994.0 | 75.09 | 75.1 | Epidemiology of viral hepatitis and hepatocellular carcinoma. | Hashem B El-Serag | Gastroenterology | 2012 | 22537432 | No |
935 | 3986 | 1993.0 | 101.84 | 50.9 | Nonparametric permutation tests for functional neuroimaging: a primer with examples. | Thomas E Nichols, Andrew P Holmes | Hum Brain Mapp | 2002 | 11747097 | Yes |
936 | 1993 | 1993.0 | 58.56 | 58.6 | Pancreatic cancer. | Manuel Hidalgo | N Engl J Med | 2010 | 20427809 | No |
937 | 1992 | 1992.0 | 66.16 | 66.2 | Eye movements in reading and information processing: 20 years of research. | K Rayner | Psychol Bull | 1998 | 9849112 | No |
938 | 1992 | 1992.0 | 66.89 | 66.9 | Human error: models and management. | J Reason | BMJ | 2000 | 10720363 | Yes |
939 | 1992 | 1992.0 | 48.46 | 48.5 | Rab GTPases as coordinators of vesicle traffic. | Harald Stenmark | Nat Rev Mol Cell Biol | 2009 | 19603039 | No |
940 | 1991 | 1991.0 | 0.0 | 0.0 | The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. | U E Loening | Biochem J | 1967 | 5339944 | Yes |
941 | 3971 | 1985.5 | 121.05 | 60.5 | The number of people with glaucoma worldwide in 2010 and 2020. | H A Quigley, A T Broman | Br J Ophthalmol | 2006 | 16488940 | Yes |
942 | 3970 | 1985.0 | 105.07 | 52.5 | The heat-shock proteins. | S Lindquist, E A Craig | Annu Rev Genet | 1988 | 2853609 | No |
943 | 1981 | 1981.0 | 51.74 | 51.7 | Inferring the historical patterns of biological evolution. | M Pagel | Nature | 1999 | 10553904 | Yes |
944 | 3962 | 1981.0 | 110.43 | 55.2 | UniFrac: a new phylogenetic method for comparing microbial communities. | Catherine Lozupone, Rob Knight | Appl Environ Microbiol | 2005 | 16332807 | Yes |
945 | 1980 | 1980.0 | 67.13 | 67.1 | The unfolded protein response: controlling cell fate decisions under ER stress and beyond. | Claudio Hetz | Nat Rev Mol Cell Biol | 2012 | 22251901 | No |
946 | 5936 | 1978.7 | 159.02 | 53.0 | Cortical surface-based analysis. I. Segmentation and surface reconstruction. | A M Dale, B Fischl, M I Sereno | Neuroimage | 1999 | 9931268 | Yes |
947 | 1978 | 1978.0 | 62.07 | 62.1 | Fetal origins of coronary heart disease. | D J Barker | BMJ | 1995 | 7613432 | No |
948 | 3954 | 1977.0 | 0.0 | 0.0 | Genetic regulatory mechanisms in the synthesis of proteins. | F Jacob, J Monod | J Mol Biol | 1961 | 13718526 | Yes |
949 | 1973 | 1973.0 | 58.14 | 58.1 | Protein oxidation and aging. | E R Stadtman | Science | 1992 | 1355616 | No |
950 | 1973 | 1973.0 | 39.32 | 39.3 | NK cell recognition. | Lewis L Lanier | Annu Rev Immunol | 2005 | 15771571 | No |
951 | 5918 | 1972.7 | 176.18 | 58.7 | Immunity, inflammation, and cancer. | Sergei I Grivennikov, Florian R Greten, Michael Karin | Cell | 2010 | 20303878 | No |
952 | 1972 | 1972.0 | 50.6 | 50.6 | Determination and analysis of urea and guanidine hydrochloride denaturation curves. | C N Pace | Methods Enzymol | 1986 | 3773761 | Yes |
953 | 1972 | 1972.0 | 53.48 | 53.5 | Working memory: looking back and looking forward. | Alan Baddeley | Nat Rev Neurosci | 2003 | 14523382 | No |
954 | 1971 | 1971.0 | 53.04 | 53.0 | Descending control of pain. | Mark J Millan | Prog Neurobiol | 2002 | 12034378 | No |
955 | 1971 | 1971.0 | 51.11 | 51.1 | Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. | Jane Glazebrook | Annu Rev Phytopathol | 2005 | 16078883 | No |
956 | 3936 | 1968.0 | 0.0 | 0.0 | Judgment under Uncertainty: Heuristics and Biases. | A Tversky, D Kahneman | Science | 1974 | 17835457 | Yes |
957 | 1967 | 1967.0 | 0.0 | 0.0 | Purinergic nerves. | G Burnstock | Pharmacol Rev | 1972 | 4404211 | No |
958 | 3933 | 1966.5 | 108.76 | 54.4 | Alzheimer's disease: the amyloid cascade hypothesis. | J A Hardy, G A Higgins | Science | 1992 | 1566067 | No |
959 | 1964 | 1964.0 | 53.72 | 53.7 | Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. | J Folkman | N Engl J Med | 1995 | 7491141 | No |
960 | 1964 | 1964.0 | 65.79 | 65.8 | Plant products as antimicrobial agents. | M M Cowan | Clin Microbiol Rev | 1999 | 10515903 | No |
961 | 1959 | 1959.0 | 47.08 | 47.1 | Pathways towards and away from Alzheimer's disease. | Mark P Mattson | Nature | 2004 | 15295589 | No |
962 | 1958 | 1958.0 | 70.44 | 70.4 | Determination of glutathione and glutathione disulfide in biological samples. | M E Anderson | Methods Enzymol | 1985 | 4088074 | Yes |
963 | 1958 | 1958.0 | 60.88 | 60.9 | A two process model of sleep regulation. | A A Borbély | Hum Neurobiol | 1982 | 7185792 | Yes |
964 | 1958 | 1958.0 | 53.64 | 53.6 | T cell exhaustion. | E John Wherry | Nat Immunol | 2011 | 21739672 | No |
965 | 5873 | 1957.7 | 121.94 | 40.6 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel, J D Roberts, R A Zakour | Methods Enzymol | 1987 | 3323813 | Yes |
966 | 11739 | 1956.5 | 268.69 | 44.8 | NMRPipe: a multidimensional spectral processing system based on UNIX pipes. | F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A Bax | J Biomol NMR | 1995 | 8520220 | Yes |
967 | 3913 | 1956.5 | 101.75 | 50.9 | Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. | Hashem B El-Serag, K Lenhard Rudolph | Gastroenterology | 2007 | 17570226 | No |
968 | 3912 | 1956.0 | 81.24 | 40.6 | Mammalian MAP kinase signalling cascades. | L Chang, M Karin | Nature | 2001 | 11242034 | No |
969 | 1956 | 1956.0 | 49.88 | 49.9 | Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. | Edward V Loftus | Gastroenterology | 2004 | 15168363 | Yes |
970 | 3911 | 1955.5 | 96.71 | 48.4 | Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. | G G Glenner, C W Wong | Biochem Biophys Res Commun | 1984 | 6375662 | Yes |
971 | 1954 | 1954.0 | 64.51 | 64.5 | Spinal and supraspinal factors in human muscle fatigue. | S C Gandevia | Physiol Rev | 2001 | 11581501 | No |
972 | 1954 | 1954.0 | 0.0 | 0.0 | The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. | S V Boyden | J Exp Med | 1951 | 14803635 | Yes |
973 | 5861 | 1953.7 | 117.0 | 39.0 | Control of regulatory T cell development by the transcription factor Foxp3. | Shohei Hori, Takashi Nomura, Shimon Sakaguchi | Science | 2003 | 12522256 | Yes |
974 | 3907 | 1953.5 | 127.26 | 63.6 | A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. | Gary J Bennett, Y-K Xie | Pain | 1988 | 2837713 | Yes |
975 | 1952 | 1952.0 | 56.35 | 56.4 | Estimating causal effects from large data sets using propensity scores. | D B Rubin | Ann Intern Med | 1997 | 9382394 | No |
976 | 1950 | 1950.0 | 83.56 | 83.6 | Missing data analysis: making it work in the real world. | John W Graham | Annu Rev Psychol | 2009 | 18652544 | No |
977 | 1949 | 1949.0 | 40.79 | 40.8 | Mechanisms of intracellular protein transport. | J E Rothman | Nature | 1994 | 7969419 | No |
978 | 1948 | 1948.0 | 54.56 | 54.6 | The biology of interleukin-6. | T Kishimoto | Blood | 1989 | 2473791 | No |
979 | 1946 | 1946.0 | 41.74 | 41.7 | Role of angiogenesis in tumor growth and metastasis. | Judah Folkman | Semin Oncol | 2002 | 12516034 | No |
980 | 1944 | 1944.0 | 0.0 | 0.0 | Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. | A Fleckenstein | Annu Rev Pharmacol Toxicol | 1977 | 326161 | No |
981 | 3886 | 1943.0 | 0.0 | 0.0 | Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. | W R Morrison, L M Smith | J Lipid Res | 1964 | 14221106 | Yes |
982 | 1942 | 1942.0 | 0.0 | 0.0 | Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. | J P Chamberlain | Anal Biochem | 1979 | 543547 | Yes |
983 | 3882 | 1941.0 | 102.97 | 51.5 | Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. | M Matsuda, R A DeFronzo | Diabetes Care | 1999 | 10480510 | Yes |
984 | 3882 | 1941.0 | 0.0 | 0.0 | A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. | R F Beers, I W Sizer | J Biol Chem | 1952 | 14938361 | Yes |
985 | 3878 | 1939.0 | 93.06 | 46.5 | Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. | B A Reynolds, S Weiss | Science | 1992 | 1553558 | Yes |
986 | 3877 | 1938.5 | 157.06 | 78.5 | Extracellular vesicles: exosomes, microvesicles, and friends. | Graça Raposo, Willem Stoorvogel | J Cell Biol | 2013 | 23420871 | No |
987 | 1938 | 1938.0 | 0.0 | 0.0 | The oxidation of ribonuclease with performic acid. | C H Hirs | J Biol Chem | 1956 | 13319283 | Yes |
988 | 1937 | 1937.0 | 39.92 | 39.9 | Mechanisms of type-I- and type-II-interferon-mediated signalling. | Leonidas C Platanias | Nat Rev Immunol | 2005 | 15864272 | No |
989 | 7745 | 1936.2 | 176.93 | 44.2 | Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. | A Krogh, B Larsson, G von Heijne, E L Sonnhammer | J Mol Biol | 2001 | 11152613 | Yes |
990 | 3872 | 1936.0 | 0.0 | 0.0 | Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. | I W McLean, P K Nakane | J Histochem Cytochem | 1974 | 4374474 | Yes |
991 | 1936 | 1936.0 | 57.45 | 57.5 | Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. | Claudiu T Supuran | Nat Rev Drug Discov | 2008 | 18167490 | No |
992 | 1934 | 1934.0 | 58.0 | 58.0 | Intracellular calcium homeostasis. | E Carafoli | Annu Rev Biochem | 1987 | 3304139 | No |
993 | 1934 | 1934.0 | 42.57 | 42.6 | The mitogen-activated protein kinase signal transduction pathway. | R J Davis | J Biol Chem | 1993 | 8325833 | No |
994 | 3866 | 1933.0 | 85.09 | 42.5 | Lessons from hereditary colorectal cancer. | K W Kinzler, B Vogelstein | Cell | 1996 | 8861899 | No |
995 | 1933 | 1933.0 | 35.4 | 35.4 | ATM and related protein kinases: safeguarding genome integrity. | Yosef Shiloh | Nat Rev Cancer | 2003 | 12612651 | No |
996 | 11594 | 1932.3 | 406.77 | 67.8 | Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. | Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell Parkin | Int J Cancer | 2010 | 21351269 | Yes |
997 | 3864 | 1932.0 | 179.9 | 90.0 | Stages and processes of self-change of smoking: toward an integrative model of change. | J O Prochaska, C C DiClemente | J Consult Clin Psychol | 1983 | 6863699 | Yes |
998 | 1932 | 1932.0 | 36.8 | 36.8 | Automated electron microscope tomography using robust prediction of specimen movements. | David N Mastronarde | J Struct Biol | 2005 | 16182563 | Yes |
999 | 1931 | 1931.0 | 67.12 | 67.1 | Simplified calculation of body-surface area. | R D Mosteller | N Engl J Med | 1987 | 3657876 | Yes |
1000 | 1931 | 1931.0 | 66.36 | 66.4 | Qualitative research: standards, challenges, and guidelines. | K Malterud | Lancet | 2001 | 11513933 | Yes |
1001 | 3861 | 1930.5 | 84.93 | 42.5 | The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. | A J Ridley, A Hall | Cell | 1992 | 1643657 | Yes |
1002 | 17363 | 1929.2 | 387.05 | 43.0 | Cytoscape: a software environment for integrated models of biomolecular interaction networks. | Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey Ideker | Genome Res | 2003 | 14597658 | Yes |
1003 | 1929 | 1929.0 | 35.83 | 35.8 | In situ hybridization: an improved whole-mount method for Xenopus embryos. | R M Harland | Methods Cell Biol | 1991 | 1811161 | Yes |
1004 | 5786 | 1928.7 | 276.04 | 92.0 | HISAT: a fast spliced aligner with low memory requirements. | Daehwan Kim, Ben Langmead, Steven L Salzberg | Nat Methods | 2015 | 25751142 | Yes |
1005 | 1928 | 1928.0 | 82.04 | 82.0 | The validity and practicality of sun-reactive skin types I through VI. | T B Fitzpatrick | Arch Dermatol | 1988 | 3377516 | Yes |
1006 | 1928 | 1928.0 | 86.28 | 86.3 | The Children's Depression, Inventory (CDI). | M Kovacs | Psychopharmacol Bull | 1985 | 4089116 | Yes |
1007 | 3852 | 1926.0 | 108.32 | 54.2 | Insulin-like growth factors and their binding proteins: biological actions. | J I Jones, D R Clemmons | Endocr Rev | 1995 | 7758431 | No |
1008 | 1926 | 1926.0 | 71.57 | 71.6 | International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. | C Herrmann | J Psychosom Res | 1997 | 9055211 | No |
1009 | 1926 | 1926.0 | 0.0 | 0.0 | Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. | M Kunitz | J Gen Physiol | 1947 | 19873496 | Yes |
1010 | 1925 | 1925.0 | 39.44 | 39.4 | CpG motifs in bacterial DNA and their immune effects. | Arthur M Krieg | Annu Rev Immunol | 2002 | 11861616 | No |
1011 | 3849 | 1924.5 | 0.0 | 0.0 | Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. | A C Chang, S N Cohen | J Bacteriol | 1978 | 149110 | Yes |
1012 | 3847 | 1923.5 | 110.56 | 55.3 | Application of phylogenetic networks in evolutionary studies. | Daniel H Huson, David Bryant | Mol Biol Evol | 2006 | 16221896 | Yes |
1013 | 5766 | 1922.0 | 224.59 | 74.9 | Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. | G Muyzer, E C de Waal, A G Uitterlinden | Appl Environ Microbiol | 1993 | 7683183 | Yes |
1014 | 1919 | 1919.0 | 40.72 | 40.7 | A cell culture model for T lymphocyte clonal anergy. | R H Schwartz | Science | 1990 | 2113314 | Yes |
1015 | 3834 | 1917.0 | 0.0 | 0.0 | Variations in pattern of pubertal changes in girls. | W A Marshall, J M Tanner | Arch Dis Child | 1969 | 5785179 | Yes |
1016 | 1917 | 1917.0 | 0.0 | 0.0 | Analysis of tissue and arterial blood temperatures in the resting human forearm. | H H Pennes | J Appl Physiol | 1948 | 18887578 | Yes |
1017 | 5750 | 1916.7 | 194.43 | 64.8 | Parallel organization of functionally segregated circuits linking basal ganglia and cortex. | G E Alexander, M R DeLong, P L Strick | Annu Rev Neurosci | 1986 | 3085570 | No |
1018 | 1916 | 1916.0 | 0.0 | 0.0 | Influences of glucose loading and of injected insulin on hepatic glucose output. | R Steele | Ann N Y Acad Sci | 1959 | 13833973 | Yes |
1019 | 3831 | 1915.5 | 147.08 | 73.5 | The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. | P F Lovibond, S H Lovibond | Behav Res Ther | 1995 | 7726811 | Yes |
1020 | 1915 | 1915.0 | 81.4 | 81.4 | A rating scale for drug-induced akathisia. | T R Barnes | Br J Psychiatry | 1989 | 2574607 | Yes |
1021 | 1915 | 1915.0 | 55.49 | 55.5 | Accurate Coulomb-fitting basis sets for H to Rn. | Florian Weigend | Phys Chem Chem Phys | 2006 | 16633586 | Yes |
1022 | 1913 | 1913.0 | 65.12 | 65.1 | Intermediate filaments as mechanical integrators of cellular space. | E Lazarides | Nature | 1980 | 7188712 | Yes |
1023 | 3826 | 1913.0 | 78.94 | 39.5 | Network biology: understanding the cell's functional organization. | Albert-László Barabási, Zoltán N Oltvai | Nat Rev Genet | 2004 | 14735121 | No |
1024 | 5739 | 1913.0 | 223.96 | 74.7 | featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. | Yang Liao, Gordon K Smyth, Wei Shi | Bioinformatics | 2014 | 24227677 | Yes |
1025 | 1911 | 1911.0 | 54.44 | 54.4 | The blood-brain barrier in health and chronic neurodegenerative disorders. | Berislav V Zlokovic | Neuron | 2008 | 18215617 | No |
1026 | 1910 | 1910.0 | 47.3 | 47.3 | DNA topoisomerases. | J C Wang | Annu Rev Biochem | 1985 | 2992360 | No |
1027 | 3818 | 1909.0 | 125.18 | 62.6 | Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. | Jeng-Da Chai, Martin Head-Gordon | Phys Chem Chem Phys | 2008 | 18989472 | Yes |
1028 | 1908 | 1908.0 | 0.0 | 0.0 | Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? | J V Neel | Am J Hum Genet | 1962 | 13937884 | Yes |
1029 | 1907 | 1907.0 | 0.0 | 0.0 | A rating instrument for anxiety disorders. | W W Zung | Psychosomatics | 1971 | 5172928 | Yes |
1030 | 3813 | 1906.5 | 0.0 | 0.0 | Acetylornithinase of Escherichia coli: partial purification and some properties. | H J Vogel, D M Bonner | J Biol Chem | 1956 | 13278318 | Yes |
1031 | 1906 | 1906.0 | 51.21 | 51.2 | DNA topoisomerase poisons as antitumor drugs. | L F Liu | Annu Rev Biochem | 1989 | 2549853 | No |
1032 | 1906 | 1906.0 | 53.85 | 53.9 | The episodic buffer: a new component of working memory? | Baddeley | Trends Cogn Sci | 2000 | 11058819 | Yes |
1033 | 3808 | 1904.0 | 103.62 | 51.8 | Inositol phosphates and cell signalling. | M J Berridge, R F Irvine | Nature | 1989 | 2550825 | No |
1034 | 1904 | 1904.0 | 0.0 | 0.0 | Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. | A Breslow | Ann Surg | 1970 | 5477666 | Yes |
1035 | 3803 | 1901.5 | 96.18 | 48.1 | Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. | P J Barnes, M Karin | N Engl J Med | 1997 | 9091804 | No |
1036 | 1901 | 1901.0 | 0.0 | 0.0 | On estimating the relation between blood group and disease. | B Woolf | Ann Hum Genet | 1955 | 14388528 | Yes |
1037 | 3800 | 1900.0 | 171.34 | 85.7 | Multiwfn: a multifunctional wavefunction analyzer. | Tian Lu, Feiwu Chen | J Comput Chem | 2012 | 22162017 | Yes |
1038 | 3795 | 1897.5 | 94.07 | 47.0 | Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. | M Nei, T Gojobori | Mol Biol Evol | 1986 | 3444411 | Yes |
1039 | 1897 | 1897.0 | 40.36 | 40.4 | Molecular bases for circadian clocks. | J C Dunlap | Cell | 1999 | 9988221 | No |
1040 | 1896 | 1896.0 | 42.66 | 42.7 | Biology of natural killer cells. | G Trinchieri | Adv Immunol | 1989 | 2683611 | No |
1041 | 1896 | 1896.0 | 43.12 | 43.1 | Signal sequences. The limits of variation. | G von Heijne | J Mol Biol | 1985 | 4032478 | Yes |
1042 | 1896 | 1896.0 | 84.61 | 84.6 | Brain dopamine receptors. | P Seeman | Pharmacol Rev | 1980 | 6117090 | No |
1043 | 1894 | 1894.0 | 0.0 | 0.0 | In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. | T R Chen | Exp Cell Res | 1977 | 65285 | Yes |
1044 | 3786 | 1893.0 | 90.17 | 45.1 | Base-calling of automated sequencer traces using phred. II. Error probabilities. | B Ewing, P Green | Genome Res | 1998 | 9521922 | Yes |
1045 | 1893 | 1893.0 | 75.92 | 75.9 | Approximate entropy as a measure of system complexity. | S M Pincus | Proc Natl Acad Sci U S A | 1991 | 11607165 | Yes |
1046 | 1893 | 1893.0 | 40.24 | 40.2 | Metastasis to bone: causes, consequences and therapeutic opportunities. | Gregory R Mundy | Nat Rev Cancer | 2002 | 12154351 | No |
1047 | 1891 | 1891.0 | 55.2 | 55.2 | Excitotoxic cell death. | D W Choi | J Neurobiol | 1992 | 1361523 | No |
1048 | 1890 | 1890.0 | 57.16 | 57.2 | Calbindin D-28k and parvalbumin in the rat nervous system. | M R Celio | Neuroscience | 1990 | 2199841 | Yes |
1049 | 1889 | 1889.0 | 0.0 | 0.0 | A modified card sorting test sensitive to frontal lobe defects. | H E Nelson | Cortex | 1976 | 1009768 | Yes |
1050 | 5663 | 1887.7 | 153.92 | 51.3 | Canonical sampling through velocity rescaling. | Giovanni Bussi, Davide Donadio, Michele Parrinello | J Chem Phys | 2007 | 17212484 | Yes |
1051 | 1887 | 1887.0 | 43.41 | 43.4 | Defensins: antimicrobial peptides of innate immunity. | Tomas Ganz | Nat Rev Immunol | 2003 | 12949495 | No |
1052 | 1885 | 1885.0 | 0.0 | 0.0 | Complete nucleotide sequence of the Escherichia coli plasmid pBR322. | J G Sutcliffe | Cold Spring Harb Symp Quant Biol | 1979 | 383387 | Yes |
1053 | 5655 | 1885.0 | 0.0 | 0.0 | Research diagnostic criteria: rationale and reliability. | R L Spitzer, J Endicott, E Robins | Arch Gen Psychiatry | 1978 | 655775 | Yes |
1054 | 1885 | 1885.0 | 34.87 | 34.9 | Signaling--2000 and beyond. | T Hunter | Cell | 2000 | 10647936 | No |
1055 | 1883 | 1883.0 | 52.23 | 52.2 | Epidemiology of insomnia: what we know and what we still need to learn. | Maurice M Ohayon | Sleep Med Rev | 2002 | 12531146 | Yes |
1056 | 3762 | 1881.0 | 0.0 | 0.0 | An efficient mRNA-dependent translation system from reticulocyte lysates. | H R Pelham, R J Jackson | Eur J Biochem | 1976 | 823012 | Yes |
1057 | 3762 | 1881.0 | 96.87 | 48.4 | Leptin and the regulation of body weight in mammals. | J M Friedman, J L Halaas | Nature | 1998 | 9796811 | No |
1058 | 5641 | 1880.3 | 142.5 | 47.5 | GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. | R A Jefferson, T A Kavanagh, M W Bevan | EMBO J | 1987 | 3327686 | Yes |
1059 | 1880 | 1880.0 | 49.05 | 49.0 | Flow-mediated endothelial mechanotransduction. | P F Davies | Physiol Rev | 1995 | 7624393 | No |
1060 | 1880 | 1880.0 | 43.96 | 44.0 | A clearer vision for in vivo imaging. | R Weissleder | Nat Biotechnol | 2001 | 11283581 | No |
1061 | 1878 | 1878.0 | 0.0 | 0.0 | Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. | D M Neville | J Biol Chem | 1971 | 5127429 | Yes |
1062 | 1878 | 1878.0 | 62.09 | 62.1 | Social cognitive theory: an agentic perspective. | A Bandura | Annu Rev Psychol | 2001 | 11148297 | Yes |
1063 | 3755 | 1877.5 | 89.68 | 44.8 | Brown adipose tissue: function and physiological significance. | Barbara Cannon, Jan Nedergaard | Physiol Rev | 2004 | 14715917 | No |
1064 | 1876 | 1876.0 | 46.17 | 46.2 | Animal mitochondrial genomes. | J L Boore | Nucleic Acids Res | 1999 | 10101183 | No |
1065 | 7498 | 1874.5 | 188.63 | 47.2 | p53 mutations in human cancers. | M Hollstein, D Sidransky, B Vogelstein, C C Harris | Science | 1991 | 1905840 | No |
1066 | 7489 | 1872.2 | 194.79 | 48.7 | Matrix elasticity directs stem cell lineage specification. | Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E Discher | Cell | 2006 | 16923388 | Yes |
1067 | 3741 | 1870.5 | 87.21 | 43.6 | The Fas death factor. | S Nagata, P Golstein | Science | 1995 | 7533326 | No |
1068 | 3740 | 1870.0 | 77.25 | 38.6 | Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. | Rudolf Jaenisch, Adrian Bird | Nat Genet | 2003 | 12610534 | No |
1069 | 3737 | 1868.5 | 77.21 | 38.6 | Smad-dependent and Smad-independent pathways in TGF-beta family signalling. | Rik Derynck, Ying E Zhang | Nature | 2003 | 14534577 | No |
1070 | 16815 | 1868.3 | 1027.36 | 114.2 | Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. | Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray | Int J Cancer | 2015 | 25220842 | Yes |
1071 | 1868 | 1868.0 | 55.16 | 55.2 | Japanese Classification of Gastric Carcinoma - 2nd English Edition - | Japanese Gastric Cancer Association | Gastric Cancer | 1998 | 11957040 | Yes |
1072 | 3735 | 1867.5 | 0.0 | 0.0 | Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. | J G Rheinwald, H Green | Cell | 1975 | 1052771 | Yes |
1073 | 7464 | 1866.0 | 261.77 | 65.4 | A brief measure for assessing generalized anxiety disorder: the GAD-7. | Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd Löwe | Arch Intern Med | 2006 | 16717171 | Yes |
1074 | 3730 | 1865.0 | 122.36 | 61.2 | Oxygen toxicity, oxygen radicals, transition metals and disease. | B Halliwell, J M Gutteridge | Biochem J | 1984 | 6326753 | No |
1075 | 1863 | 1863.0 | 39.31 | 39.3 | The expanding role of mitochondria in apoptosis. | X Wang | Genes Dev | 2001 | 11711427 | No |
1076 | 1862 | 1862.0 | 62.98 | 63.0 | The use of a plus-maze to measure anxiety in the mouse. | R G Lister | Psychopharmacology (Berl) | 1987 | 3110839 | Yes |
1077 | 3723 | 1861.5 | 76.85 | 38.4 | The Wnt signaling pathway in development and disease. | Catriona Y Logan, Roel Nusse | Annu Rev Cell Dev Biol | 2004 | 15473860 | No |
1078 | 3719 | 1859.5 | 80.9 | 40.5 | Raster3D: photorealistic molecular graphics. | E A Merritt, D J Bacon | Methods Enzymol | 1997 | 18488322 | Yes |
1079 | 1858 | 1858.0 | 57.52 | 57.5 | Hazards of heavy metal contamination. | Lars Järup | Br Med Bull | 2003 | 14757716 | No |
1080 | 1858 | 1858.0 | 64.26 | 64.3 | The free-energy principle: a unified brain theory? | Karl Friston | Nat Rev Neurosci | 2010 | 20068583 | No |
1081 | 3713 | 1856.5 | 95.03 | 47.5 | Cutaneous wound healing. | A J Singer, R A Clark | N Engl J Med | 1999 | 10471461 | No |
1082 | 1854 | 1854.0 | 45.69 | 45.7 | Thioredoxin. | A Holmgren | Annu Rev Biochem | 1985 | 3896121 | No |
1083 | 1853 | 1853.0 | 63.27 | 63.3 | Keratoconus. | Y S Rabinowitz | Surv Ophthalmol | 1998 | 9493273 | No |
1084 | 3703 | 1851.5 | 108.18 | 54.1 | Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. | B J Marshall, J R Warren | Lancet | 1984 | 6145023 | Yes |
1085 | 1851 | 1851.0 | 41.55 | 41.5 | Theta oscillations in the hippocampus. | György Buzsáki | Neuron | 2002 | 11832222 | No |
1086 | 1849 | 1849.0 | 33.87 | 33.9 | The regulation of E2F by pRB-family proteins. | N Dyson | Genes Dev | 1998 | 9694791 | No |
1087 | 3697 | 1848.5 | 85.02 | 42.5 | Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. | T Miyashita, J C Reed | Cell | 1995 | 7834749 | Yes |
1088 | 1847 | 1847.0 | 49.95 | 50.0 | Accurate description of van der Waals complexes by density functional theory including empirical corrections. | Stefan Grimme | J Comput Chem | 2004 | 15224390 | Yes |
1089 | 1846 | 1846.0 | 37.91 | 37.9 | Signalling pathways of the TNF superfamily: a double-edged sword. | Bharat B Aggarwal | Nat Rev Immunol | 2003 | 12949498 | No |
1090 | 3691 | 1845.5 | 88.2 | 44.1 | The acute respiratory distress syndrome. | L B Ware, M A Matthay | N Engl J Med | 2000 | 10793167 | No |
1091 | 5532 | 1844.0 | 0.0 | 0.0 | A rapid method for the isolation of functional thymus-derived murine lymphocytes. | M H Julius, E Simpson, L A Herzenberg | Eur J Immunol | 1973 | 4587740 | Yes |
1092 | 3688 | 1844.0 | 0.0 | 0.0 | Immunoassay of insulin with insulin-antibody precipitate. | C N Hales, P J Randle | Biochem J | 1963 | 13952078 | Yes |
1093 | 1843 | 1843.0 | 49.23 | 49.2 | Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. | R D Pascual-Marqui | Methods Find Exp Clin Pharmacol | 2002 | 12575463 | No |
1094 | 1842 | 1842.0 | 50.02 | 50.0 | Mechanisms of hepatic fibrogenesis. | Scott L Friedman | Gastroenterology | 2008 | 18471545 | No |
1095 | 1840 | 1840.0 | 0.0 | 0.0 | The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. | G S Manning | Q Rev Biophys | 1978 | 353876 | No |
1096 | 1840 | 1840.0 | 47.34 | 47.3 | Dopamine, learning and motivation. | Roy A Wise | Nat Rev Neurosci | 2004 | 15152198 | No |
1097 | 3679 | 1839.5 | 95.26 | 47.6 | Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. | Michael T Lin, M Flint Beal | Nature | 2006 | 17051205 | No |
1098 | 3673 | 1836.5 | 90.07 | 45.0 | The future of genetic studies of complex human diseases. | N Risch, K Merikangas | Science | 1996 | 8801636 | Yes |
1099 | 3672 | 1836.0 | 168.46 | 84.2 | The Health Belief Model: a decade later. | N K Janz, M H Becker | Health Educ Q | 1984 | 6392204 | No |
1100 | 3669 | 1834.5 | 0.0 | 0.0 | Polymyositis and dermatomyositis (first of two parts). | A Bohan, J B Peter | N Engl J Med | 1975 | 1090839 | No |
1101 | 7331 | 1832.8 | 256.44 | 64.1 | Reporting results of cancer treatment. | A B Miller, B Hoogstraten, M Staquet, A Winkler | Cancer | 1981 | 7459811 | Yes |
1102 | 1832 | 1832.0 | 49.28 | 49.3 | Hepatitis B virus infection. | W M Lee | N Engl J Med | 1997 | 9392700 | No |
1103 | 1831 | 1831.0 | 0.0 | 0.0 | A simple fluorometric assay for lipoperoxide in blood plasma. | K Yagi | Biochem Med | 1976 | 962904 | Yes |
1104 | 20123 | 1829.4 | 440.61 | 40.1 | Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. | Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P Mesirov | Proc Natl Acad Sci U S A | 2005 | 16199517 | Yes |
1105 | 1829 | 1829.0 | 53.76 | 53.8 | The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. | G P Chrousos | N Engl J Med | 1995 | 7715646 | No |
1106 | 3658 | 1829.0 | 72.42 | 36.2 | Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. | M Karin, Y Ben-Neriah | Annu Rev Immunol | 2000 | 10837071 | No |
1107 | 1829 | 1829.0 | 51.46 | 51.5 | The physiology of glucagon-like peptide 1. | Jens Juul Holst | Physiol Rev | 2007 | 17928588 | No |
1108 | 5482 | 1827.3 | 178.87 | 59.6 | Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. | C Lord, M Rutter, A Le Couteur | J Autism Dev Disord | 1994 | 7814313 | Yes |
1109 | 7307 | 1826.8 | 0.0 | 0.0 | Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. | D J Sahn, A DeMaria, J Kisslo, A Weyman | Circulation | 1978 | 709763 | Yes |
1110 | 1823 | 1823.0 | 68.27 | 68.3 | Physiological aspects of primary hypertension. | B Folkow | Physiol Rev | 1982 | 6461865 | No |
1111 | 5469 | 1823.0 | 116.34 | 38.8 | EMBOSS: the European Molecular Biology Open Software Suite. | P Rice, I Longden, A Bleasby | Trends Genet | 2000 | 10827456 | Yes |
1112 | 1823 | 1823.0 | 46.08 | 46.1 | Cancer chemoprevention with dietary phytochemicals. | Young-Joon Surh | Nat Rev Cancer | 2003 | 14570043 | No |
1113 | 1823 | 1823.0 | 48.84 | 48.8 | A theory of cortical responses. | Karl Friston | Philos Trans R Soc Lond B Biol Sci | 2005 | 15937014 | No |
1114 | 5469 | 1823.0 | 177.24 | 59.1 | The brain's default network: anatomy, function, and relevance to disease. | Randy L Buckner, Jessica R Andrews-Hanna, Daniel L Schacter | Ann N Y Acad Sci | 2008 | 18400922 | No |
1115 | 1822 | 1822.0 | 0.0 | 0.0 | Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. | S Cohen | J Biol Chem | 1962 | 13880319 | Yes |
1116 | 1819 | 1819.0 | 37.19 | 37.2 | Antiviral actions of interferons. | C E Samuel | Clin Microbiol Rev | 2001 | 11585785 | No |
1117 | 1818 | 1818.0 | 39.18 | 39.2 | Thrombin signalling and protease-activated receptors. | S R Coughlin | Nature | 2000 | 11001069 | No |
1118 | 1818 | 1818.0 | 37.08 | 37.1 | Systems biology: a brief overview. | Hiroaki Kitano | Science | 2002 | 11872829 | No |
1119 | 7264 | 1816.0 | 245.06 | 61.3 | Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. | A J Hughes, S E Daniel, L Kilford, A J Lees | J Neurol Neurosurg Psychiatry | 1992 | 1564476 | Yes |
1120 | 3632 | 1816.0 | 94.41 | 47.2 | The endophenotype concept in psychiatry: etymology and strategic intentions. | Irving I Gottesman, Todd D Gould | Am J Psychiatry | 2003 | 12668349 | No |
1121 | 14526 | 1815.8 | 413.45 | 51.7 | Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. | R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A Erlich | Science | 1988 | 2448875 | Yes |
1122 | 1814 | 1814.0 | 40.18 | 40.2 | The immunopathogenesis of sepsis. | Jonathan Cohen | Nature | 2002 | 12490963 | No |
1123 | 1814 | 1814.0 | 0.0 | 0.0 | A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. | D A Robinson | IEEE Trans Biomed Eng | 1963 | 14121113 | Yes |
1124 | 3627 | 1813.5 | 163.43 | 81.7 | The Brief Symptom Inventory: an introductory report. | L R Derogatis, N Melisaratos | Psychol Med | 1983 | 6622612 | Yes |
1125 | 1813 | 1813.0 | 37.36 | 37.4 | DNA topoisomerases: structure, function, and mechanism. | J J Champoux | Annu Rev Biochem | 2001 | 11395412 | No |
1126 | 5436 | 1812.0 | 156.96 | 52.3 | Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. | F E Harrell, K L Lee, D B Mark | Stat Med | 1996 | 8668867 | No |
1127 | 1811 | 1811.0 | 59.17 | 59.2 | TGFβ signalling in context. | Joan Massagué | Nat Rev Mol Cell Biol | 2012 | 22992590 | No |
1128 | 1804 | 1804.0 | 60.92 | 60.9 | Physiological actions of taurine. | R J Huxtable | Physiol Rev | 1992 | 1731369 | No |
1129 | 1802 | 1802.0 | 49.88 | 49.9 | A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. | P J Goodford | J Med Chem | 1985 | 3892003 | Yes |
1130 | 1802 | 1802.0 | 39.98 | 40.0 | TRP channels as cellular sensors. | David E Clapham | Nature | 2003 | 14654832 | No |
1131 | 5403 | 1801.0 | 136.98 | 45.7 | Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. | Z N Oltvai, C L Milliman, S J Korsmeyer | Cell | 1993 | 8358790 | Yes |
1132 | 1800 | 1800.0 | 0.0 | 0.0 | High-speed scanning in human memory. | S Sternberg | Science | 1966 | 5939936 | Yes |
1133 | 5400 | 1800.0 | 179.83 | 59.9 | AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. | P G Reeves, F H Nielsen, G C Fahey | J Nutr | 1993 | 8229312 | No |
1134 | 1800 | 1800.0 | 45.78 | 45.8 | DAMPs, PAMPs and alarmins: all we need to know about danger. | Marco E Bianchi | J Leukoc Biol | 2007 | 17032697 | No |
1135 | 1798 | 1798.0 | 58.89 | 58.9 | Sick individuals and sick populations. | G Rose | Int J Epidemiol | 1985 | 3872850 | Yes |
1136 | 1798 | 1798.0 | 40.95 | 41.0 | Cellular mechanisms of insulin resistance. | G I Shulman | J Clin Invest | 2000 | 10903330 | No |
1137 | 1798 | 1798.0 | 0.0 | 0.0 | On respiratory impairment in cancer cells. | O Warburg | Science | 1956 | 13351639 | Yes |
1138 | 5392 | 1797.3 | 125.9 | 42.0 | A new statistical method for haplotype reconstruction from population data. | M Stephens, N J Smith, P Donnelly | Am J Hum Genet | 2001 | 11254454 | Yes |
1139 | 1797 | 1797.0 | 0.0 | 0.0 | A classification of hand preference by association analysis. | M Annett | Br J Psychol | 1970 | 5457503 | Yes |
1140 | 1796 | 1796.0 | 88.55 | 88.5 | Performance-oriented assessment of mobility problems in elderly patients. | M E Tinetti | J Am Geriatr Soc | 1986 | 3944402 | Yes |
1141 | 7179 | 1794.8 | 0.0 | 0.0 | Antibiotic susceptibility testing by a standardized single disk method. | A W Bauer, W M Kirby, J C Sherris, M Turck | Am J Clin Pathol | 1966 | 5325707 | Yes |
1142 | 1794 | 1794.0 | 41.48 | 41.5 | DNA topoisomerases. | J C Wang | Annu Rev Biochem | 1996 | 8811192 | No |
1143 | 1793 | 1793.0 | 0.0 | 0.0 | A theory of cerebellar cortex. | D Marr | J Physiol | 1969 | 5784296 | Yes |
1144 | 3585 | 1792.5 | 0.0 | 0.0 | Mathematical model for studying genetic variation in terms of restriction endonucleases. | M Nei, W H Li | Proc Natl Acad Sci U S A | 1979 | 291943 | Yes |
1145 | 3578 | 1789.0 | 120.19 | 60.1 | Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. | R A DeFronzo, E Ferrannini | Diabetes Care | 1991 | 2044434 | No |
1146 | 1789 | 1789.0 | 42.18 | 42.2 | Global cancer statistics in the year 2000. | D M Parkin | Lancet Oncol | 2001 | 11905707 | No |
1147 | 1789 | 1789.0 | 45.24 | 45.2 | The global health burden of infection-associated cancers in the year 2002. | Donald Maxwell Parkin | Int J Cancer | 2006 | 16404738 | Yes |
1148 | 1789 | 1789.0 | 38.9 | 38.9 | The complex language of chromatin regulation during transcription. | Shelley L Berger | Nature | 2007 | 17522673 | No |
1149 | 1789 | 1789.0 | 51.56 | 51.6 | Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. | Gökhan S Hotamisligil | Cell | 2010 | 20303879 | No |
1150 | 7155 | 1788.8 | 275.4 | 68.8 | The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. | T F Heatherton, L T Kozlowski, R C Frecker, K O Fagerström | Br J Addict | 1991 | 1932883 | Yes |
1151 | 1788 | 1788.0 | 43.72 | 43.7 | The mitochondrial permeability transition pore and its role in cell death. | M Crompton | Biochem J | 1999 | 10393078 | No |
1152 | 1788 | 1788.0 | 0.0 | 0.0 | The measurement of volume changes in human limbs. | R J Whitney | J Physiol | 1953 | 13085295 | Yes |
1153 | 5358 | 1786.0 | 133.71 | 44.6 | APE: Analyses of Phylogenetics and Evolution in R language. | Emmanuel Paradis, Julien Claude, Korbinian Strimmer | Bioinformatics | 2004 | 14734327 | Yes |
1154 | 1785 | 1785.0 | 46.12 | 46.1 | The hydrogen bond in the solid state. | Thomas Steiner | Angew Chem Int Ed Engl | 2002 | 12491444 | Yes |
1155 | 3568 | 1784.0 | 124.76 | 62.4 | Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. | M H Zweig, G Campbell | Clin Chem | 1993 | 8472349 | No |
1156 | 1784 | 1784.0 | 52.1 | 52.1 | Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. | A Dunaif | Endocr Rev | 1997 | 9408743 | No |
1157 | 1784 | 1784.0 | 46.32 | 46.3 | Negative refraction makes a perfect lens | Pendry | Phys Rev Lett | 2000 | 11041972 | Yes |
1158 | 1784 | 1784.0 | 33.04 | 33.0 | Mechanisms of alternative pre-messenger RNA splicing. | Douglas L Black | Annu Rev Biochem | 2003 | 12626338 | No |
1159 | 1783 | 1783.0 | 66.06 | 66.1 | Why patients use alternative medicine: results of a national study. | J A Astin | JAMA | 1998 | 9605899 | Yes |
1160 | 1782 | 1782.0 | 67.47 | 67.5 | Recognition-by-components: a theory of human image understanding. | Irving Biederman | Psychol Rev | 1987 | 3575582 | Yes |
1161 | 7125 | 1781.2 | 283.09 | 70.8 | A simple technique for quantitation of low levels of DNA damage in individual cells. | N P Singh, M T McCoy, R R Tice, E L Schneider | Exp Cell Res | 1988 | 3345800 | Yes |
1162 | 1781 | 1781.0 | 0.0 | 0.0 | Estimability and estimation in case-referent studies. | O Miettinen | Am J Epidemiol | 1976 | 1251836 | Yes |
1163 | 1781 | 1781.0 | 59.0 | 59.0 | Heavy metal intensification of DAB-based HRP reaction product. | J C Adams | J Histochem Cytochem | 1981 | 7252134 | Yes |
1164 | 1781 | 1781.0 | 87.42 | 87.4 | Microplastics in the marine environment. | Anthony L Andrady | Mar Pollut Bull | 2011 | 21742351 | No |
1165 | 5340 | 1780.0 | 104.66 | 34.9 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. | Jason D Fontenot, Marc A Gavin, Alexander Y Rudensky | Nat Immunol | 2003 | 12612578 | Yes |
1166 | 3557 | 1778.5 | 74.98 | 37.5 | Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. | C D Nobes, A Hall | Cell | 1995 | 7536630 | Yes |
1167 | 1778 | 1778.0 | 45.76 | 45.8 | Drug-like properties and the causes of poor solubility and poor permeability. | C A Lipinski | J Pharmacol Toxicol Methods | 2000 | 11274893 | No |
1168 | 3555 | 1777.5 | 101.38 | 50.7 | Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. | Kresse, Hafner | Phys Rev B Condens Matter | 1994 | 10010505 | Yes |
1169 | 3554 | 1777.0 | 122.25 | 61.1 | Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. | G Di Chiara, A Imperato | Proc Natl Acad Sci U S A | 1988 | 2899326 | Yes |
1170 | 1777 | 1777.0 | 0.0 | 0.0 | The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. | S Hestrin | J Biol Chem | 1949 | 18133390 | Yes |
1171 | 1776 | 1776.0 | 40.04 | 40.0 | A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. | J SantaLucia | Proc Natl Acad Sci U S A | 1998 | 9465037 | Yes |
1172 | 1776 | 1776.0 | 36.79 | 36.8 | Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. | R J Kaufman | Genes Dev | 1999 | 10346810 | No |
1173 | 3551 | 1775.5 | 0.0 | 0.0 | Maturation of the head of bacteriophage T4. I. DNA packaging events. | U K Laemmli, M Favre | J Mol Biol | 1973 | 4204102 | Yes |
1174 | 7102 | 1775.5 | 176.33 | 44.1 | Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. | A Shevchenko, M Wilm, O Vorm, M Mann | Anal Chem | 1996 | 8779443 | Yes |
1175 | 1774 | 1774.0 | 44.66 | 44.7 | The dawning era of polymer therapeutics. | Ruth Duncan | Nat Rev Drug Discov | 2003 | 12750738 | No |
1176 | 1774 | 1774.0 | 49.25 | 49.2 | The extracellular matrix: not just pretty fibrils. | Richard O Hynes | Science | 2009 | 19965464 | No |
1177 | 3545 | 1772.5 | 0.0 | 0.0 | Multiple receptors for dopamine. | J W Kebabian, D B Calne | Nature | 1979 | 215920 | No |
1178 | 3545 | 1772.5 | 89.82 | 44.9 | Measuring the thickness of the human cerebral cortex from magnetic resonance images. | B Fischl, A M Dale | Proc Natl Acad Sci U S A | 2000 | 10984517 | Yes |
1179 | 1771 | 1771.0 | 0.0 | 0.0 | Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4332693 | Yes |
1180 | 1771 | 1771.0 | 0.0 | 0.0 | The influence of some cations on an adenosine triphosphatase from peripheral nerves. | J C Skou | Biochim Biophys Acta | 1957 | 13412736 | Yes |
1181 | 1769 | 1769.0 | 0.0 | 0.0 | Comparison of the predicted and observed secondary structure of T4 phage lysozyme. | B W Matthews | Biochim Biophys Acta | 1975 | 1180967 | Yes |
1182 | 1769 | 1769.0 | 43.19 | 43.2 | Metabolomics--the link between genotypes and phenotypes. | Oliver Fiehn | Plant Mol Biol | 2002 | 11860207 | No |
1183 | 1769 | 1769.0 | 46.08 | 46.1 | Interfaces and the driving force of hydrophobic assembly. | David Chandler | Nature | 2005 | 16193038 | No |
1184 | 1769 | 1769.0 | 79.45 | 79.5 | Role of nrf2 in oxidative stress and toxicity. | Qiang Ma | Annu Rev Pharmacol Toxicol | 2013 | 23294312 | No |
1185 | 5298 | 1766.0 | 172.42 | 57.5 | Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. | R L Spitzer, K Kroenke, J B Williams | JAMA | 1999 | 10568646 | Yes |
1186 | 1765 | 1765.0 | 58.59 | 58.6 | Health consequences of intimate partner violence. | Jacquelyn C Campbell | Lancet | 2002 | 11965295 | No |
1187 | 7060 | 1765.0 | 151.38 | 37.8 | WebLogo: a sequence logo generator. | Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E Brenner | Genome Res | 2004 | 15173120 | Yes |
1188 | 1764 | 1764.0 | 45.46 | 45.5 | Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. | Fiona Turnbull | Lancet | 2003 | 14615107 | Yes |
1189 | 1763 | 1763.0 | 60.91 | 60.9 | Guided Search 2.0 A revised model of visual search. | J M Wolfe | Psychon Bull Rev | 1994 | 24203471 | Yes |
1190 | 3524 | 1762.0 | 86.0 | 43.0 | Protein folding in the cell. | M J Gething, J Sambrook | Nature | 1992 | 1731198 | No |
1191 | 3517 | 1758.5 | 93.63 | 46.8 | Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. | K D McCarthy, J de Vellis | J Cell Biol | 1980 | 6248568 | Yes |
1192 | 1758 | 1758.0 | 95.83 | 95.8 | The assessment of clinical skills/competence/performance. | G E Miller | Acad Med | 1990 | 2400509 | Yes |
1193 | 1758 | 1758.0 | 0.0 | 0.0 | The etiology of chondromalacia patellae. | R E Outerbridge | J Bone Joint Surg Br | 1961 | 14038135 | Yes |
1194 | 1756 | 1756.0 | 36.9 | 36.9 | An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. | R M Esnouf | J Mol Graph Model | 1997 | 9385560 | Yes |
1195 | 1756 | 1756.0 | 54.93 | 54.9 | Social determinants of health inequalities. | Michael Marmot | Lancet | 2005 | 15781105 | Yes |
1196 | 1755 | 1755.0 | 38.9 | 38.9 | Developmental regulation of the growth plate. | Henry M Kronenberg | Nature | 2003 | 12748651 | No |
1197 | 7020 | 1755.0 | 284.75 | 71.2 | Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. | Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg Lang | Behav Res Methods | 2009 | 19897823 | Yes |
1198 | 1754 | 1754.0 | 48.0 | 48.0 | G proteins and dual control of adenylate cyclase. | A G Gilman | Cell | 1984 | 6321035 | Yes |
1199 | 1754 | 1754.0 | 42.51 | 42.5 | Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. | B L Wajchenberg | Endocr Rev | 2000 | 11133069 | No |
1200 | 1753 | 1753.0 | 103.11 | 103.1 | Determination and quantification of content validity. | M R Lynn | Nurs Res | 1986 | 3640358 | Yes |
1201 | 1753 | 1753.0 | 62.23 | 62.2 | The role of hormone receptors and GTP-regulatory proteins in membrane transduction. | M Rodbell | Nature | 1980 | 6101906 | Yes |
1202 | 1753 | 1753.0 | 57.14 | 57.1 | Calculation of substrate oxidation rates in vivo from gaseous exchange. | K N Frayn | J Appl Physiol Respir Environ Exerc Physiol | 1983 | 6618956 | Yes |
1203 | 1752 | 1752.0 | 0.0 | 0.0 | Protein denaturation. | C Tanford | Adv Protein Chem | 1968 | 4882248 | No |
1204 | 1747 | 1747.0 | 43.58 | 43.6 | Targeting PI3K signalling in cancer: opportunities, challenges and limitations. | Jeffrey A Engelman | Nat Rev Cancer | 2009 | 19629070 | No |
1205 | 1746 | 1746.0 | 81.67 | 81.7 | Determinants of low birth weight: methodological assessment and meta-analysis. | M S Kramer | Bull World Health Organ | 1987 | 3322602 | No |
1206 | 1746 | 1746.0 | 49.17 | 49.2 | New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. | R Y Tsien | Biochemistry | 1980 | 6770893 | Yes |
1207 | 3492 | 1746.0 | 66.82 | 33.4 | Rho GTPases in cell biology. | Sandrine Etienne-Manneville, Alan Hall | Nature | 2002 | 12478284 | No |
1208 | 1746 | 1746.0 | 46.11 | 46.1 | Follicular helper CD4 T cells (TFH). | Shane Crotty | Annu Rev Immunol | 2011 | 21314428 | No |
1209 | 12220 | 1745.7 | 281.79 | 40.3 | Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. | Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman | Genome Biol | 2002 | 12184808 | Yes |
1210 | 5232 | 1744.0 | 173.89 | 58.0 | Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. | L Excoffier, P E Smouse, J M Quattro | Genetics | 1992 | 1644282 | Yes |
1211 | 3488 | 1744.0 | 135.76 | 67.9 | The biofilm matrix. | Hans-Curt Flemming, Jost Wingender | Nat Rev Microbiol | 2010 | 20676145 | No |
1212 | 1743 | 1743.0 | 58.92 | 58.9 | Drugs of abuse: anatomy, pharmacology and function of reward pathways. | G F Koob | Trends Pharmacol Sci | 1992 | 1604710 | No |
1213 | 1743 | 1743.0 | 71.29 | 71.3 | Doxil®--the first FDA-approved nano-drug: lessons learned. | Yechezkel Barenholz | J Control Release | 2012 | 22484195 | No |
1214 | 1742 | 1742.0 | 62.21 | 62.2 | A cortical network for directed attention and unilateral neglect. | M M Mesulam | Ann Neurol | 1981 | 7032417 | No |
1215 | 1742 | 1742.0 | 0.0 | 0.0 | A personality scale of manifest anxiety. | J A Taylor | J Abnorm Psychol | 1953 | 13052352 | Yes |
1216 | 3483 | 1741.5 | 0.0 | 0.0 | A complementation analysis of the restriction and modification of DNA in Escherichia coli. | H W Boyer, D Roulland-Dussoix | J Mol Biol | 1969 | 4896022 | Yes |
1217 | 1741 | 1741.0 | 40.28 | 40.3 | Steroid receptor regulated transcription of specific genes and gene networks. | K R Yamamoto | Annu Rev Genet | 1985 | 3909942 | No |
1218 | 1741 | 1741.0 | 0.0 | 0.0 | Positional information and the spatial pattern of cellular differentiation. | L Wolpert | J Theor Biol | 1969 | 4390734 | Yes |
1219 | 1741 | 1741.0 | 0.0 | 0.0 | Transplacental carcinogenesis by stilbestrol. | J Folkman | N Engl J Med | 1971 | 5556579 | Yes |
1220 | 1740 | 1740.0 | 54.93 | 54.9 | An overview of brominated flame retardants in the environment. | Cynthia A de Wit | Chemosphere | 2002 | 11999784 | No |
1221 | 1738 | 1738.0 | 40.58 | 40.6 | Neutrophils and immunity: challenges and opportunities. | Carl Nathan | Nat Rev Immunol | 2006 | 16498448 | No |
1222 | 3475 | 1737.5 | 111.97 | 56.0 | Efficient pseudopotentials for plane-wave calculations. | Troullier, Martins | Phys Rev B Condens Matter | 1991 | 9997467 | Yes |
1223 | 1734 | 1734.0 | 0.0 | 0.0 | Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. | M J Casadaban | J Mol Biol | 1976 | 781293 | Yes |
1224 | 1734 | 1734.0 | 34.25 | 34.2 | Approaching the asymptote? Evolution and revolution in immunology. | C A Janeway | Cold Spring Harb Symp Quant Biol | 1989 | 2700931 | No |
1225 | 1734 | 1734.0 | 68.3 | 68.3 | Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. | H U Wittchen | J Psychiatr Res | 1994 | 8064641 | No |
1226 | 1733 | 1733.0 | 44.93 | 44.9 | The pathophysiology of tumor necrosis factors. | P Vassalli | Annu Rev Immunol | 1992 | 1590993 | No |
1227 | 1733 | 1733.0 | 46.37 | 46.4 | Interleukin-6: an overview. | J Van Snick | Annu Rev Immunol | 1990 | 2188664 | No |
1228 | 5198 | 1732.7 | 136.41 | 45.5 | Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. | G S Hotamisligil, N S Shargill, B M Spiegelman | Science | 1993 | 7678183 | Yes |
1229 | 1731 | 1731.0 | 35.05 | 35.0 | Notch signalling: a simple pathway becomes complex. | Sarah J Bray | Nat Rev Mol Cell Biol | 2006 | 16921404 | No |
1230 | 3458 | 1729.0 | 88.77 | 44.4 | The biology of vascular endothelial growth factor. | N Ferrara, T Davis-Smyth | Endocr Rev | 1997 | 9034784 | No |
1231 | 3456 | 1728.0 | 76.11 | 38.1 | Cell death: critical control points. | Nika N Danial, Stanley J Korsmeyer | Cell | 2004 | 14744432 | No |
1232 | 1728 | 1728.0 | 72.37 | 72.4 | The Resonating Valence Bond State in La2CuO4 and Superconductivity. | P W Anderson | Science | 1987 | 17818979 | Yes |
1233 | 1727 | 1727.0 | 39.2 | 39.2 | The synaptic vesicle cycle: a cascade of protein-protein interactions. | T C Südhof | Nature | 1995 | 7791897 | No |
1234 | 3454 | 1727.0 | 107.47 | 53.7 | Nonparametric statistical testing of EEG- and MEG-data. | Eric Maris, Robert Oostenveld | J Neurosci Methods | 2007 | 17517438 | Yes |
1235 | 1726 | 1726.0 | 38.92 | 38.9 | The distribution of secondary growths in cancer of the breast. 1889. | S Paget | Cancer Metastasis Rev | 1989 | 2673568 | No |
1236 | 3451 | 1725.5 | 152.48 | 76.2 | The MOS social support survey. | C D Sherbourne, A L Stewart | Soc Sci Med | 1991 | 2035047 | Yes |
1237 | 3450 | 1725.0 | 93.59 | 46.8 | Prediction of protein antigenic determinants from amino acid sequences. | T P Hopp, K R Woods | Proc Natl Acad Sci U S A | 1981 | 6167991 | Yes |
1238 | 5174 | 1724.7 | 113.7 | 37.9 | Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. | A Nicholls, K A Sharp, B Honig | Proteins | 1991 | 1758883 | Yes |
1239 | 1723 | 1723.0 | 57.57 | 57.6 | Epidemiological features of chronic low-back pain. | G B Andersson | Lancet | 1999 | 10470716 | No |
1240 | 5168 | 1722.7 | 172.68 | 57.6 | FastTree 2--approximately maximum-likelihood trees for large alignments. | Morgan N Price, Paramvir S Dehal, Adam P Arkin | PLoS One | 2010 | 20224823 | Yes |
1241 | 1722 | 1722.0 | 0.0 | 0.0 | ATPase activity of myosin correlated with speed of muscle shortening. | M Bárány | J Gen Physiol | 1967 | 4227924 | Yes |
1242 | 1721 | 1721.0 | 62.34 | 62.3 | Cyclosporine. | B D Kahan | N Engl J Med | 1989 | 2687689 | No |
1243 | 1721 | 1721.0 | 49.31 | 49.3 | Biofilms: microbial life on surfaces. | Rodney M Donlan | Emerg Infect Dis | 2002 | 12194761 | No |
1244 | 1718 | 1718.0 | 70.65 | 70.7 | Perception of risk. | P Slovic | Science | 1987 | 3563507 | Yes |
1245 | 1718 | 1718.0 | 32.56 | 32.6 | CD4+ CD25+ suppressor T cells: more questions than answers. | Ethan M Shevach | Nat Rev Immunol | 2002 | 12093005 | No |
1246 | 1718 | 1718.0 | 43.16 | 43.2 | Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. | D Lavanchy | J Viral Hepat | 2004 | 14996343 | No |
1247 | 1717 | 1717.0 | 0.0 | 0.0 | Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. | J N Dumont | J Morphol | 1972 | 4109871 | Yes |
1248 | 5149 | 1716.3 | 233.1 | 77.7 | Some statistical methods useful in circulation research. | S Wallenstein, C L Zucker, J L Fleiss | Circ Res | 1980 | 7379260 | Yes |
1249 | 1716 | 1716.0 | 0.0 | 0.0 | Dynamic properties of mammalian skeletal muscles. | R I Close | Physiol Rev | 1972 | 4256989 | No |
1250 | 1716 | 1716.0 | 36.52 | 36.5 | Structure and regulation of voltage-gated Ca2+ channels. | W A Catterall | Annu Rev Cell Dev Biol | 2000 | 11031246 | No |
1251 | 1713 | 1713.0 | 54.13 | 54.1 | The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. | B L Fredrickson | Am Psychol | 2001 | 11315248 | Yes |
1252 | 1713 | 1713.0 | 44.89 | 44.9 | Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. | Scott L Friedman | Physiol Rev | 2008 | 18195085 | No |
1253 | 6849 | 1712.2 | 134.74 | 33.7 | Transformation of intact yeast cells treated with alkali cations. | H Ito, Y Fukuda, K Murata, A Kimura | J Bacteriol | 1983 | 6336730 | Yes |
1254 | 1712 | 1712.0 | 0.0 | 0.0 | The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. | R Ross | J Cell Biol | 1971 | 4327464 | Yes |
1255 | 1711 | 1711.0 | 64.05 | 64.0 | Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. | D R Janero | Free Radic Biol Med | 1990 | 2079232 | No |
1256 | 11977 | 1711.0 | 297.63 | 42.5 | Induction of pluripotent stem cells from adult human fibroblasts by defined factors. | Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka | Cell | 2007 | 18035408 | Yes |
1257 | 1710 | 1710.0 | 35.8 | 35.8 | MicroRNA biogenesis: coordinated cropping and dicing. | V Narry Kim | Nat Rev Mol Cell Biol | 2005 | 15852042 | No |
1258 | 1710 | 1710.0 | 50.99 | 51.0 | MYC on the path to cancer. | Chi V Dang | Cell | 2012 | 22464321 | No |
1259 | 3416 | 1708.0 | 72.78 | 36.4 | Identification of common molecular subsequences. | T F Smith, M S Waterman | J Mol Biol | 1981 | 7265238 | Yes |
1260 | 1708 | 1708.0 | 41.91 | 41.9 | Integrating cell-signalling pathways with NF-kappaB and IKK function. | Neil D Perkins | Nat Rev Mol Cell Biol | 2007 | 17183360 | No |
1261 | 3415 | 1707.5 | 0.0 | 0.0 | The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. | A E Bolton, W M Hunter | Biochem J | 1973 | 4733239 | Yes |
1262 | 3415 | 1707.5 | 91.13 | 45.6 | Cloned glutamate receptors. | M Hollmann, S Heinemann | Annu Rev Neurosci | 1994 | 8210177 | No |
1263 | 1705 | 1705.0 | 0.0 | 0.0 | Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. | E M Witkin | Bacteriol Rev | 1976 | 795416 | No |
1264 | 1705 | 1705.0 | 50.93 | 50.9 | Intestinal mucosal barrier function in health and disease. | Jerrold R Turner | Nat Rev Immunol | 2009 | 19855405 | No |
1265 | 1704 | 1704.0 | 36.63 | 36.6 | Mechanisms of cancer drug resistance. | Michael M Gottesman | Annu Rev Med | 2002 | 11818492 | No |
1266 | 3405 | 1702.5 | 93.4 | 46.7 | Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. | K B Mullis, F A Faloona | Methods Enzymol | 1987 | 3431465 | Yes |
1267 | 6810 | 1702.5 | 279.06 | 69.8 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | J Clin Epidemiol | 2009 | 19631508 | No |
1268 | 1702 | 1702.0 | 54.57 | 54.6 | Glutamate: a neurotransmitter in mammalian brain. | F Fonnum | J Neurochem | 1984 | 6139418 | No |
1269 | 5104 | 1701.3 | 100.59 | 33.5 | Surfing the p53 network. | B Vogelstein, D Lane, A J Levine | Nature | 2000 | 11099028 | No |
1270 | 1699 | 1699.0 | 0.0 | 0.0 | Dendritic organization in the neurons of the visual and motor cortices of the cat. | D A Sholl | J Anat | 1953 | 13117757 | Yes |
1271 | 1698 | 1698.0 | 0.0 | 0.0 | Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. | M Wong-Riley | Brain Res | 1979 | 223730 | Yes |
1272 | 1698 | 1698.0 | 0.0 | 0.0 | The statistical analysis of enzyme kinetic data. | W W Cleland | Adv Enzymol Relat Areas Mol Biol | 1967 | 4881884 | No |
1273 | 1698 | 1698.0 | 0.0 | 0.0 | A graphic method for the determination and presentation of binding parameters in a complex system. | H E Rosenthal | Anal Biochem | 1967 | 6048188 | Yes |
1274 | 3395 | 1697.5 | 91.54 | 45.8 | Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering | Nie, Emory | Science | 1997 | 9027306 | Yes |
1275 | 1697 | 1697.0 | 56.49 | 56.5 | Pineal melatonin: cell biology of its synthesis and of its physiological interactions. | R J Reiter | Endocr Rev | 1991 | 1649044 | No |
1276 | 1697 | 1697.0 | 58.07 | 58.1 | Large-scale neurocognitive networks and distributed processing for attention, language, and memory. | M M Mesulam | Ann Neurol | 1990 | 2260847 | No |
1277 | 1697 | 1697.0 | 54.45 | 54.5 | Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. | M Zasloff | Proc Natl Acad Sci U S A | 1987 | 3299384 | Yes |
1278 | 1697 | 1697.0 | 49.88 | 49.9 | Flavonoids as antioxidants. | P G Pietta | J Nat Prod | 2000 | 10924197 | No |
1279 | 3393 | 1696.5 | 86.03 | 43.0 | Matrix metalloproteinases. | H Nagase, J F Woessner | J Biol Chem | 1999 | 10419448 | No |
1280 | 1695 | 1695.0 | 51.51 | 51.5 | Inhibited spontaneous emission in solid-state physics and electronics. | Yablonovitch | Phys Rev Lett | 1987 | 10034639 | Yes |
1281 | 1694 | 1694.0 | 36.3 | 36.3 | Molecular regulation of vessel maturation. | Rakesh K Jain | Nat Med | 2003 | 12778167 | No |
1282 | 1693 | 1693.0 | 45.95 | 46.0 | Integrins. | E Ruoslahti | J Clin Invest | 1991 | 1985087 | No |
1283 | 1693 | 1693.0 | 54.23 | 54.2 | PsychoPy--Psychophysics software in Python. | Jonathan W Peirce | J Neurosci Methods | 2007 | 17254636 | Yes |
1284 | 1692 | 1692.0 | 0.0 | 0.0 | Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. | A F Habeeb | Anal Biochem | 1966 | 4161471 | Yes |
1285 | 1692 | 1692.0 | 44.71 | 44.7 | Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. | G C Walker | Microbiol Rev | 1984 | 6371470 | No |
1286 | 1692 | 1692.0 | 41.05 | 41.0 | Type III protein secretion systems in bacterial pathogens of animals and plants. | C J Hueck | Microbiol Mol Biol Rev | 1998 | 9618447 | No |
1287 | 5074 | 1691.3 | 116.82 | 38.9 | Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. | Michael W Pfaffl, Graham W Horgan, Leo Dempfle | Nucleic Acids Res | 2002 | 11972351 | Yes |
1288 | 1691 | 1691.0 | 57.39 | 57.4 | Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. | C E Mogensen | N Engl J Med | 1984 | 6690964 | Yes |
1289 | 1691 | 1691.0 | 35.67 | 35.7 | DNA methylation and human disease. | Keith D Robertson | Nat Rev Genet | 2005 | 16136652 | No |
1290 | 1689 | 1689.0 | 0.0 | 0.0 | Evolutionary rate at the molecular level. | M Kimura | Nature | 1968 | 5637732 | Yes |
1291 | 6756 | 1689.0 | 167.85 | 42.0 | Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. | C A Lipinski, F Lombardo, B W Dominy, P J Feeney | Adv Drug Deliv Rev | 2001 | 11259830 | No |
1292 | 3378 | 1689.0 | 0.0 | 0.0 | A "Direct-Coloring" Thiocholine Method For Cholinesterases. | M J Karnovsky, L Roots | J Histochem Cytochem | 1964 | 14187330 | Yes |
1293 | 16885 | 1688.5 | 536.85 | 53.7 | Measurement of protein using bicinchoninic acid. | P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C Klenk | Anal Biochem | 1985 | 3843705 | Yes |
1294 | 1687 | 1687.0 | 0.0 | 0.0 | Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. | A Krishan | J Cell Biol | 1975 | 49354 | Yes |
1295 | 1687 | 1687.0 | 0.0 | 0.0 | Why genes in pieces? | W Gilbert | Nature | 1978 | 622185 | Yes |
1296 | 1687 | 1687.0 | 31.79 | 31.8 | How eukaryotic transcriptional activators work. | M Ptashne | Nature | 1988 | 3050531 | No |
1297 | 3373 | 1686.5 | 0.0 | 0.0 | Receptive fields and functional architecture of monkey striate cortex. | D H Hubel, T N Wiesel | J Physiol | 1968 | 4966457 | Yes |
1298 | 1685 | 1685.0 | 40.79 | 40.8 | The molecular genetics of cancer. | J M Bishop | Science | 1987 | 3541204 | No |
1299 | 1685 | 1685.0 | 68.26 | 68.3 | Predicting basal metabolic rate, new standards and review of previous work. | W N Schofield | Hum Nutr Clin Nutr | 1985 | 4044297 | Yes |
1300 | 1683 | 1683.0 | 0.0 | 0.0 | Method for the determination of hexosamines in tissues. | N F Boas | J Biol Chem | 1953 | 13117829 | Yes |
1301 | 8408 | 1681.6 | 232.76 | 46.6 | Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. | Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary King | Diabetes Care | 2004 | 15111519 | Yes |
1302 | 1680 | 1680.0 | 0.0 | 0.0 | Areas, volumes, packing and protein structure. | F M Richards | Annu Rev Biophys Bioeng | 1977 | 326146 | No |
1303 | 1680 | 1680.0 | 56.78 | 56.8 | The crisis in antibiotic resistance. | H C Neu | Science | 1992 | 1509257 | No |
1304 | 1679 | 1679.0 | 39.75 | 39.8 | Fabrication of novel biomaterials through molecular self-assembly. | Shuguang Zhang | Nat Biotechnol | 2003 | 14520402 | No |
1305 | 1679 | 1679.0 | 0.0 | 0.0 | The general adaptation syndrome and the diseases of adaptation. | H Selye | J Clin Endocrinol Metab | 1946 | 21025115 | Yes |
1306 | 1678 | 1678.0 | 41.05 | 41.0 | Evolutionary relationship of DNA sequences in finite populations. | F Tajima | Genetics | 1983 | 6628982 | Yes |
1307 | 1678 | 1678.0 | 45.08 | 45.1 | What is cognitive reserve? Theory and research application of the reserve concept. | Yaakov Stern | J Int Neuropsychol Soc | 2002 | 11939702 | No |
1308 | 1678 | 1678.0 | 0.0 | 0.0 | Plastic Embedding Mixtures For Use In Electron Microscopy. | H H Mollenhauer | Stain Technol | 1964 | 14127791 | Yes |
1309 | 1678 | 1678.0 | 0.0 | 0.0 | The theory and applications of the exchange of inert gas at the lungs and tissues. | S S Kety | Pharmacol Rev | 1951 | 14833874 | Yes |
1310 | 1677 | 1677.0 | 37.47 | 37.5 | Exploring complex networks. | S H Strogatz | Nature | 2001 | 11258382 | No |
1311 | 1677 | 1677.0 | 46.26 | 46.3 | An index to quantify an individual's scientific research output. | J E Hirsch | Proc Natl Acad Sci U S A | 2005 | 16275915 | Yes |
1312 | 1677 | 1677.0 | 0.0 | 0.0 | Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. | J Spizizen | Proc Natl Acad Sci U S A | 1958 | 16590310 | Yes |
1313 | 3352 | 1676.0 | 94.2 | 47.1 | Biochemistry of multidrug resistance mediated by the multidrug transporter. | M M Gottesman, I Pastan | Annu Rev Biochem | 1993 | 8102521 | No |
1314 | 1675 | 1675.0 | 61.24 | 61.2 | Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). | G G Glenner | N Engl J Med | 1980 | 6154243 | No |
1315 | 1674 | 1674.0 | 34.56 | 34.6 | Cancer and the chemokine network. | Fran Balkwill | Nat Rev Cancer | 2004 | 15229479 | No |
1316 | 3348 | 1674.0 | 111.49 | 55.7 | Wnt/β-catenin signaling and disease. | Hans Clevers, Roel Nusse | Cell | 2012 | 22682243 | No |
1317 | 6693 | 1673.2 | 0.0 | 0.0 | Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. | E A Jaffe, R L Nachman, C G Becker, C R Minick | J Clin Invest | 1973 | 4355998 | Yes |
1318 | 1671 | 1671.0 | 0.0 | 0.0 | Drugs which inhibit prostaglandin biosynthesis. | R J Flower | Pharmacol Rev | 1974 | 4208101 | Yes |
1319 | 1670 | 1670.0 | 58.63 | 58.6 | Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? | B Halliwell | Lancet | 1994 | 7915779 | No |
1320 | 1670 | 1670.0 | 60.97 | 61.0 | Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. | Sergio Pecorelli | Int J Gynaecol Obstet | 2009 | 19367689 | No |
1321 | 1669 | 1669.0 | 0.0 | 0.0 | An improved procedure for serum creatine phosphokinase determination. | S B Rosalki | J Lab Clin Med | 1967 | 4381359 | Yes |
1322 | 1669 | 1669.0 | 39.7 | 39.7 | Solvent-accessible surfaces of proteins and nucleic acids. | M L Connolly | Science | 1983 | 6879170 | Yes |
1323 | 1668 | 1668.0 | 0.0 | 0.0 | Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. | J A Miller | Cancer Res | 1970 | 4915745 | No |
1324 | 11675 | 1667.9 | 429.54 | 61.4 | Assessing the quality of reports of randomized clinical trials: is blinding necessary? | A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuay | Control Clin Trials | 1996 | 8721797 | Yes |
1325 | 1667 | 1667.0 | 58.24 | 58.2 | Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. | A H Conney | Cancer Res | 1982 | 6814745 | No |
1326 | 1666 | 1666.0 | 0.0 | 0.0 | Mode of cell migration to the superficial layers of fetal monkey neocortex. | P Rakic | J Comp Neurol | 1972 | 4624784 | Yes |
1327 | 3332 | 1666.0 | 72.35 | 36.2 | Integrin signaling. | F G Giancotti, E Ruoslahti | Science | 1999 | 10446041 | No |
1328 | 1666 | 1666.0 | 0.0 | 0.0 | Chromatographic Separation Of Human Brain Gangliosides. | L Svennerholm | J Neurochem | 1963 | 14066623 | Yes |
1329 | 3327 | 1663.5 | 0.0 | 0.0 | Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. | J Marmur, P Doty | J Mol Biol | 1962 | 14470099 | Yes |
1330 | 1663 | 1663.0 | 44.82 | 44.8 | Dengue and dengue hemorrhagic fever. | D J Gubler | Clin Microbiol Rev | 1998 | 9665979 | No |
1331 | 3326 | 1663.0 | 81.5 | 40.8 | Liver fibrosis. | Ramón Bataller, David A Brenner | J Clin Invest | 2005 | 15690074 | No |
1332 | 1663 | 1663.0 | 45.96 | 46.0 | Network pharmacology: the next paradigm in drug discovery. | Andrew L Hopkins | Nat Chem Biol | 2008 | 18936753 | No |
1333 | 3326 | 1663.0 | 97.09 | 48.5 | The inflammasomes. | Kate Schroder, Jurg Tschopp | Cell | 2010 | 20303873 | No |
1334 | 1662 | 1662.0 | 56.36 | 56.4 | Serum albumin. | T Peters | Adv Protein Chem | 1985 | 3904348 | No |
1335 | 1662 | 1662.0 | 38.99 | 39.0 | The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. | D M Kingsley | Genes Dev | 1994 | 8299934 | No |
1336 | 3322 | 1661.0 | 0.0 | 0.0 | Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. | M Grunstein, D S Hogness | Proc Natl Acad Sci U S A | 1975 | 1105573 | Yes |
1337 | 1660 | 1660.0 | 49.21 | 49.2 | Introduction and General Overview of Cyclodextrin Chemistry. | József Szejtli | Chem Rev | 1998 | 11848947 | Yes |
1338 | 1658 | 1658.0 | 0.0 | 0.0 | Carbonic anhydrase: chemistry, physiology, and inhibition. | T H Maren | Physiol Rev | 1967 | 4964060 | No |
1339 | 1657 | 1657.0 | 55.71 | 55.7 | Global epidemiology of oral and oropharyngeal cancer. | Saman Warnakulasuriya | Oral Oncol | 2009 | 18804401 | No |
1340 | 3313 | 1656.5 | 0.0 | 0.0 | The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. | T Omura, R Sato | J Biol Chem | 1964 | 14209972 | Yes |
1341 | 1656 | 1656.0 | 52.39 | 52.4 | The atom economy--a search for synthetic efficiency. | B M Trost | Science | 1991 | 1962206 | Yes |
1342 | 1656 | 1656.0 | 46.17 | 46.2 | Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. | H LeVine | Protein Sci | 1993 | 8453378 | Yes |
1343 | 1656 | 1656.0 | 35.11 | 35.1 | The effect of infections on susceptibility to autoimmune and allergic diseases. | Jean-Francois Bach | N Engl J Med | 2002 | 12239261 | No |
1344 | 1655 | 1655.0 | 47.51 | 47.5 | Cell biology and molecular basis of denitrification. | W G Zumft | Microbiol Mol Biol Rev | 1997 | 9409151 | No |
1345 | 3310 | 1655.0 | 74.42 | 37.2 | Monocyte and macrophage heterogeneity. | Siamon Gordon, Philip R Taylor | Nat Rev Immunol | 2005 | 16322748 | No |
1346 | 1655 | 1655.0 | 44.28 | 44.3 | Using circular dichroism spectra to estimate protein secondary structure. | Norma J Greenfield | Nat Protoc | 2006 | 17406547 | Yes |
1347 | 3308 | 1654.0 | 76.6 | 38.3 | Amino acid substitution matrices from protein blocks. | S Henikoff, J G Henikoff | Proc Natl Acad Sci U S A | 1992 | 1438297 | Yes |
1348 | 1654 | 1654.0 | 46.63 | 46.6 | Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. | Robert E Marx | J Oral Maxillofac Surg | 2003 | 12966493 | Yes |
1349 | 1652 | 1652.0 | 37.66 | 37.7 | Effects of cytochalasin and phalloidin on actin. | J A Cooper | J Cell Biol | 1987 | 3312229 | No |
1350 | 1652 | 1652.0 | 0.0 | 0.0 | Pedigrees of some mutant strains of Escherichia coli K-12. | B J Bachmann | Bacteriol Rev | 1972 | 4568763 | No |
1351 | 1649 | 1649.0 | 41.87 | 41.9 | Episodic memory: from mind to brain. | Endel Tulving | Annu Rev Psychol | 2002 | 11752477 | Yes |
1352 | 3297 | 1648.5 | 93.89 | 46.9 | ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. | B Ravel, M Newville | J Synchrotron Radiat | 2005 | 15968136 | Yes |
1353 | 6589 | 1647.2 | 153.46 | 38.4 | Use of T7 RNA polymerase to direct expression of cloned genes. | F W Studier, A H Rosenberg, J J Dunn, J W Dubendorff | Methods Enzymol | 1990 | 2199796 | Yes |
1354 | 3293 | 1646.5 | 80.55 | 40.3 | PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. | Alexander W Schüttelkopf, Daan M F van Aalten | Acta Crystallogr D Biol Crystallogr | 2004 | 15272157 | Yes |
1355 | 3292 | 1646.0 | 144.43 | 72.2 | A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. | J G Snodgrass, M Vanderwart | J Exp Psychol Hum Learn | 1980 | 7373248 | Yes |
1356 | 6584 | 1646.0 | 177.81 | 44.5 | Epithelial-mesenchymal transitions in development and disease. | Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela Nieto | Cell | 2009 | 19945376 | No |
1357 | 3291 | 1645.5 | 109.2 | 54.6 | Role of free radicals and catalytic metal ions in human disease: an overview. | B Halliwell, J M Gutteridge | Methods Enzymol | 1990 | 2172697 | No |
1358 | 1645 | 1645.0 | 48.98 | 49.0 | Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. | E M Wassermann | Electroencephalogr Clin Neurophysiol | 1998 | 9474057 | No |
1359 | 3288 | 1644.0 | 85.03 | 42.5 | Receptors for purines and pyrimidines. | V Ralevic, G Burnstock | Pharmacol Rev | 1998 | 9755289 | No |
1360 | 1644 | 1644.0 | 0.0 | 0.0 | A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. | D Mattingly | J Clin Pathol | 1962 | 14471419 | Yes |
1361 | 1644 | 1644.0 | 55.24 | 55.2 | Hypoxia-inducible factors in physiology and medicine. | Gregg L Semenza | Cell | 2012 | 22304911 | No |
1362 | 1642 | 1642.0 | 31.91 | 31.9 | Cellular roles of DNA topoisomerases: a molecular perspective. | James C Wang | Nat Rev Mol Cell Biol | 2002 | 12042765 | No |
1363 | 6564 | 1641.0 | 134.65 | 33.7 | Stem cells, cancer, and cancer stem cells. | T Reya, S J Morrison, M F Clarke, I L Weissman | Nature | 2001 | 11689955 | No |
1364 | 3279 | 1639.5 | 0.0 | 0.0 | Method for the isolation of intact islets of Langerhans from the rat pancreas. | P E Lacy, M Kostianovsky | Diabetes | 1967 | 5333500 | Yes |
1365 | 1639 | 1639.0 | 45.86 | 45.9 | The comet assay for DNA damage and repair: principles, applications, and limitations. | Andrew R Collins | Mol Biotechnol | 2004 | 15004294 | No |
1366 | 3277 | 1638.5 | 0.0 | 0.0 | New method for quantitative determination of uronic acids. | N Blumenkrantz, G Asboe-Hansen | Anal Biochem | 1973 | 4269305 | Yes |
1367 | 1638 | 1638.0 | 0.0 | 0.0 | The micronucleus test. | W Schmid | Mutat Res | 1975 | 48190 | Yes |
1368 | 4914 | 1638.0 | 157.01 | 52.3 | Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. | H Esterbauer, R J Schaur, H Zollner | Free Radic Biol Med | 1991 | 1937131 | No |
1369 | 3275 | 1637.5 | 86.03 | 43.0 | Quantum dot bioconjugates for ultrasensitive nonisotopic detection. | W C Chan, S Nie | Science | 1998 | 9748158 | Yes |
1370 | 16373 | 1637.3 | 525.82 | 52.6 | The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. | F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S Luthra | Arthritis Rheum | 1988 | 3358796 | Yes |
1371 | 1637 | 1637.0 | 45.74 | 45.7 | Turnover of inositol phospholipids and signal transduction. | Y Nishizuka | Science | 1984 | 6147898 | No |
1372 | 1637 | 1637.0 | 43.99 | 44.0 | The genetics of ageing. | Cynthia J Kenyon | Nature | 2010 | 20336132 | No |
1373 | 3273 | 1636.5 | 89.83 | 44.9 | Protein structure prediction on the Web: a case study using the Phyre server. | Lawrence A Kelley, Michael J E Sternberg | Nat Protoc | 2009 | 19247286 | Yes |
1374 | 1636 | 1636.0 | 52.59 | 52.6 | Metallothionein. | D H Hamer | Annu Rev Biochem | 1986 | 3527054 | No |
1375 | 3269 | 1634.5 | 76.46 | 38.2 | Parkinson's disease: mechanisms and models. | William Dauer, Serge Przedborski | Neuron | 2003 | 12971891 | No |
1376 | 1633 | 1633.0 | 34.05 | 34.0 | Structural features in eukaryotic mRNAs that modulate the initiation of translation. | M Kozak | J Biol Chem | 1991 | 1939050 | No |
1377 | 1632 | 1632.0 | 45.24 | 45.2 | Oxidative stress hypothesis in Alzheimer's disease. | W R Markesbery | Free Radic Biol Med | 1997 | 9165306 | No |
1378 | 3263 | 1631.5 | 78.82 | 39.4 | The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. | P Angel, M Karin | Biochim Biophys Acta | 1991 | 1751545 | No |
1379 | 1631 | 1631.0 | 36.25 | 36.2 | Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. | S L Friedman | J Biol Chem | 2000 | 10644669 | No |
1380 | 1631 | 1631.0 | 41.09 | 41.1 | Clinical application of C-reactive protein for cardiovascular disease detection and prevention. | Paul M Ridker | Circulation | 2003 | 12551853 | No |
1381 | 3261 | 1630.5 | 101.8 | 50.9 | Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. | F Denizot, R Lang | J Immunol Methods | 1986 | 3486233 | Yes |
1382 | 3261 | 1630.5 | 85.53 | 42.8 | Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. | Christian Haass, Dennis J Selkoe | Nat Rev Mol Cell Biol | 2007 | 17245412 | No |
1383 | 8152 | 1630.4 | 212.03 | 42.4 | Mapping and quantifying mammalian transcriptomes by RNA-Seq. | Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara Wold | Nat Methods | 2008 | 18516045 | Yes |
1384 | 1630 | 1630.0 | 44.97 | 45.0 | Chlorpromazine equivalent doses for the newer atypical antipsychotics. | Scott W Woods | J Clin Psychiatry | 2003 | 12823080 | No |
1385 | 1629 | 1629.0 | 38.56 | 38.6 | NADPH oxidase: an update. | B M Babior | Blood | 1999 | 10029572 | No |
1386 | 1628 | 1628.0 | 32.41 | 32.4 | Hox genes in vertebrate development. | R Krumlauf | Cell | 1994 | 7913880 | No |
1387 | 1628 | 1628.0 | 49.98 | 50.0 | Infrared spectroscopy of proteins. | Andreas Barth | Biochim Biophys Acta | 2007 | 17692815 | No |
1388 | 1627 | 1627.0 | 0.0 | 0.0 | RNA-dependent DNA polymerase in virions of RNA tumour viruses. | D Baltimore | Nature | 1970 | 4316300 | Yes |
1389 | 1626 | 1626.0 | 56.44 | 56.4 | Grounded cognition. | Lawrence W Barsalou | Annu Rev Psychol | 2008 | 17705682 | No |
1390 | 1625 | 1625.0 | 32.44 | 32.4 | Cell cycle checkpoints: preventing an identity crisis. | S J Elledge | Science | 1996 | 8939848 | No |
1391 | 3248 | 1624.0 | 71.53 | 35.8 | Protein structure comparison by alignment of distance matrices. | L Holm, C Sander | J Mol Biol | 1993 | 8377180 | Yes |
1392 | 1624 | 1624.0 | 40.07 | 40.1 | Inflammatory bowel disease: etiology and pathogenesis. | C Fiocchi | Gastroenterology | 1998 | 9649475 | No |
1393 | 3245 | 1622.5 | 0.0 | 0.0 | A fluorometric method for determination of oxidized and reduced glutathione in tissues. | P J Hissin, R Hilf | Anal Biochem | 1976 | 962076 | Yes |
1394 | 1622 | 1622.0 | 58.65 | 58.6 | Cell damage in the brain: a speculative synthesis. | B K Siesjö | J Cereb Blood Flow Metab | 1981 | 6276420 | No |
1395 | 3239 | 1619.5 | 0.0 | 0.0 | Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. | M Mihara, M Uchiyama | Anal Biochem | 1978 | 655387 | Yes |
1396 | 3239 | 1619.5 | 128.07 | 64.0 | Assays of glutathione peroxidase. | L Flohé, W A Günzler | Methods Enzymol | 1984 | 6727659 | Yes |
1397 | 1619 | 1619.0 | 49.06 | 49.1 | Extracellular ATP: effects, sources and fate. | J L Gordon | Biochem J | 1986 | 3006665 | No |
1398 | 3237 | 1618.5 | 89.21 | 44.6 | Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. | Steven E Nissen, Kathy Wolski | N Engl J Med | 2007 | 17517853 | Yes |
1399 | 9710 | 1618.3 | 279.76 | 46.6 | Positional cloning of the mouse obese gene and its human homologue. | Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M Friedman | Nature | 1994 | 7984236 | Yes |
1400 | 1618 | 1618.0 | 70.92 | 70.9 | Neurogenetic adaptive mechanisms in alcoholism. | C R Cloninger | Science | 1987 | 2882604 | Yes |
1401 | 1618 | 1618.0 | 67.63 | 67.6 | Negative symptoms in schizophrenia. Definition and reliability. | N C Andreasen | Arch Gen Psychiatry | 1982 | 7165477 | Yes |
1402 | 1618 | 1618.0 | 41.96 | 42.0 | Neurotrophins and neuronal plasticity. | H Thoenen | Science | 1995 | 7570017 | No |
1403 | 1617 | 1617.0 | 84.94 | 84.9 | Conservation of resources. A new attempt at conceptualizing stress. | S E Hobfoll | Am Psychol | 1989 | 2648906 | No |
1404 | 1617 | 1617.0 | 0.0 | 0.0 | Chromatin structure: a repeating unit of histones and DNA. | R D Kornberg | Science | 1974 | 4825889 | Yes |
1405 | 3229 | 1614.5 | 0.0 | 0.0 | Variations in the pattern of pubertal changes in boys. | W A Marshall, J M Tanner | Arch Dis Child | 1970 | 5440182 | Yes |
1406 | 3228 | 1614.0 | 92.25 | 46.1 | Building better batteries. | M Armand, J-M Tarascon | Nature | 2008 | 18256660 | No |
1407 | 3227 | 1613.5 | 87.69 | 43.8 | A scaling normalization method for differential expression analysis of RNA-seq data. | Mark D Robinson, Alicia Oshlack | Genome Biol | 2010 | 20196867 | Yes |
1408 | 1612 | 1612.0 | 37.19 | 37.2 | Cellular oncogenes and retroviruses. | J M Bishop | Annu Rev Biochem | 1983 | 6351725 | No |
1409 | 3224 | 1612.0 | 92.28 | 46.1 | Biofilms: survival mechanisms of clinically relevant microorganisms. | Rodney M Donlan, J William Costerton | Clin Microbiol Rev | 2002 | 11932229 | No |
1410 | 6445 | 1611.2 | 172.92 | 43.2 | Cancer-related inflammation. | Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill | Nature | 2008 | 18650914 | No |
1411 | 3222 | 1611.0 | 90.0 | 45.0 | The mirror-neuron system. | Giacomo Rizzolatti, Laila Craighero | Annu Rev Neurosci | 2004 | 15217330 | No |
1412 | 3218 | 1609.0 | 64.56 | 32.3 | SIFT: Predicting amino acid changes that affect protein function. | Pauline C Ng, Steven Henikoff | Nucleic Acids Res | 2003 | 12824425 | Yes |
1413 | 1607 | 1607.0 | 50.78 | 50.8 | Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. | D W Choi | Trends Neurosci | 1988 | 2469166 | No |
1414 | 1606 | 1606.0 | 47.33 | 47.3 | Metalloproteinases and their inhibitors in matrix remodeling. | L M Matrisian | Trends Genet | 1990 | 2132731 | No |
1415 | 1606 | 1606.0 | 50.51 | 50.5 | A measure of population subdivision based on microsatellite allele frequencies. | M Slatkin | Genetics | 1995 | 7705646 | Yes |
1416 | 1606 | 1606.0 | 30.3 | 30.3 | Cyclin-dependent kinases: engines, clocks, and microprocessors. | D O Morgan | Annu Rev Cell Dev Biol | 1997 | 9442875 | No |
1417 | 3210 | 1605.0 | 77.35 | 38.7 | Rapid and sensitive protein similarity searches. | D J Lipman, W R Pearson | Science | 1985 | 2983426 | Yes |
1418 | 4814 | 1604.7 | 192.22 | 64.1 | Effect of the damping function in dispersion corrected density functional theory. | Stefan Grimme, Stephan Ehrlich, Lars Goerigk | J Comput Chem | 2011 | 21370243 | Yes |
1419 | 3206 | 1603.0 | 120.7 | 60.4 | Microenvironmental regulation of tumor progression and metastasis. | Daniela F Quail, Johanna A Joyce | Nat Med | 2013 | 24202395 | No |
1420 | 1602 | 1602.0 | 35.21 | 35.2 | Bone morphogenetic proteins: multifunctional regulators of vertebrate development. | B L Hogan | Genes Dev | 1996 | 8682290 | No |
1421 | 1601 | 1601.0 | 0.0 | 0.0 | Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. | O Ouchterlony | Acta Pathol Microbiol Scand | 1953 | 13079779 | Yes |
1422 | 1600 | 1600.0 | 29.68 | 29.7 | Maximum-likelihood density modification. | T C Terwilliger | Acta Crystallogr D Biol Crystallogr | 2000 | 10944333 | Yes |
1423 | 1600 | 1600.0 | 0.0 | 0.0 | Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. | E G Gray | J Anat | 1959 | 13829103 | Yes |
1424 | 3200 | 1600.0 | 139.01 | 69.5 | miRBase: annotating high confidence microRNAs using deep sequencing data. | Ana Kozomara, Sam Griffiths-Jones | Nucleic Acids Res | 2014 | 24275495 | Yes |
1425 | 1599 | 1599.0 | 48.65 | 48.6 | Classification of inflammatory bowel disease. | J E Lennard-Jones | Scand J Gastroenterol Suppl | 1989 | 2617184 | Yes |
1426 | 1598 | 1598.0 | 51.22 | 51.2 | Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? | George A Bonanno | Am Psychol | 2004 | 14736317 | No |
1427 | 11185 | 1597.9 | 287.8 | 41.1 | Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. | William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan | N Engl J Med | 2002 | 11832527 | Yes |
1428 | 1597 | 1597.0 | 36.93 | 36.9 | VLA proteins in the integrin family: structures, functions, and their role on leukocytes. | M E Hemler | Annu Rev Immunol | 1990 | 2188667 | No |
1429 | 1597 | 1597.0 | 37.82 | 37.8 | Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. | S A Bustin | J Mol Endocrinol | 2002 | 12200227 | No |
1430 | 3193 | 1596.5 | 63.58 | 31.8 | Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. | M E Greenberg, E B Ziff | Nature | 1984 | 6090941 | Yes |
1431 | 4787 | 1595.7 | 114.16 | 38.1 | Inflammation and atherosclerosis. | Peter Libby, Paul M Ridker, Attilio Maseri | Circulation | 2002 | 11877368 | No |
1432 | 1595 | 1595.0 | 0.0 | 0.0 | Structural considerations in the interaction of DNA and acridines. | L S Lerman | J Mol Biol | 1961 | 13761054 | Yes |
1433 | 3188 | 1594.0 | 95.57 | 47.8 | The unfolded protein response: from stress pathway to homeostatic regulation. | Peter Walter, David Ron | Science | 2011 | 22116877 | No |
1434 | 3187 | 1593.5 | 78.46 | 39.2 | CAP3: A DNA sequence assembly program. | X Huang, A Madan | Genome Res | 1999 | 10508846 | Yes |
1435 | 1593 | 1593.0 | 34.79 | 34.8 | Excitatory actions of gaba during development: the nature of the nurture. | Yehezkel Ben-Ari | Nat Rev Neurosci | 2002 | 12209121 | No |
1436 | 4777 | 1592.3 | 147.76 | 49.3 | Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. | P A Wolf, R D Abbott, W B Kannel | Stroke | 1991 | 1866765 | Yes |
1437 | 1592 | 1592.0 | 0.0 | 0.0 | Computerized transverse axial scanning (tomography). 1. Description of system. | G N Hounsfield | Br J Radiol | 1973 | 4757352 | Yes |
1438 | 3184 | 1592.0 | 63.35 | 31.7 | Automated MAD and MIR structure solution. | T C Terwilliger, J Berendzen | Acta Crystallogr D Biol Crystallogr | 1999 | 10089316 | Yes |
1439 | 1592 | 1592.0 | 33.01 | 33.0 | The synaptic vesicle cycle. | Thomas C Sudhof | Annu Rev Neurosci | 2004 | 15217342 | No |
1440 | 1592 | 1592.0 | 34.72 | 34.7 | Protein homology detection by HMM-HMM comparison. | Johannes Söding | Bioinformatics | 2005 | 15531603 | Yes |
1441 | 1592 | 1592.0 | 43.48 | 43.5 | P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation. | Berk Hess | J Chem Theory Comput | 2008 | 26619985 | Yes |
1442 | 1590 | 1590.0 | 40.62 | 40.6 | Angiogenesis: an organizing principle for drug discovery? | Judah Folkman | Nat Rev Drug Discov | 2007 | 17396134 | No |
1443 | 1589 | 1589.0 | 53.73 | 53.7 | Number of people with glaucoma worldwide. | H A Quigley | Br J Ophthalmol | 1996 | 8695555 | No |
1444 | 1588 | 1588.0 | 0.0 | 0.0 | Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. | K O Fagerström | Addict Behav | 1978 | 735910 | Yes |
1445 | 1588 | 1588.0 | 0.0 | 0.0 | Paced auditory serial-addition task: a measure of recovery from concussion. | D M Gronwall | Percept Mot Skills | 1977 | 866038 | Yes |
1446 | 1588 | 1588.0 | 31.78 | 31.8 | An analysis of vertebrate mRNA sequences: intimations of translational control. | M Kozak | J Cell Biol | 1991 | 1955461 | No |
1447 | 1588 | 1588.0 | 34.69 | 34.7 | The caveolae membrane system. | R G Anderson | Annu Rev Biochem | 1998 | 9759488 | No |
1448 | 3176 | 1588.0 | 70.27 | 35.1 | Insulin signalling and the regulation of glucose and lipid metabolism. | A R Saltiel, C R Kahn | Nature | 2001 | 11742412 | Yes |
1449 | 1587 | 1587.0 | 0.0 | 0.0 | The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. | A G Pearse | J Histochem Cytochem | 1969 | 4143745 | No |
1450 | 1587 | 1587.0 | 0.0 | 0.0 | Interhemispheric differences in the localization of psychological processes in man. | B Milner | Br Med Bull | 1971 | 4937273 | No |
1451 | 1587 | 1587.0 | 128.23 | 128.2 | Minimap2: pairwise alignment for nucleotide sequences. | Heng Li | Bioinformatics | 2018 | 29750242 | Yes |
1452 | 3173 | 1586.5 | 113.54 | 56.8 | Avoiding false positives with PCR. | S Kwok, R Higuchi | Nature | 1989 | 2716852 | Yes |
1453 | 1585 | 1585.0 | 41.75 | 41.8 | Alpha-crystallin can function as a molecular chaperone. | J Horwitz | Proc Natl Acad Sci U S A | 1992 | 1438232 | Yes |
1454 | 1585 | 1585.0 | 39.94 | 39.9 | Tumor necrosis factor (TNF). | L J Old | Science | 1985 | 2413547 | Yes |
1455 | 1585 | 1585.0 | 46.45 | 46.5 | Perceptual symbol systems. | L W Barsalou | Behav Brain Sci | 1999 | 11301525 | No |
1456 | 1584 | 1584.0 | 41.95 | 42.0 | Adipose tissue, adipokines, and inflammation. | Giamila Fantuzzi | J Allergy Clin Immunol | 2005 | 15867843 | No |
1457 | 1584 | 1584.0 | 37.68 | 37.7 | Recognition of microorganisms and activation of the immune response. | Ruslan Medzhitov | Nature | 2007 | 17943118 | No |
1458 | 1583 | 1583.0 | 44.93 | 44.9 | Leptospirosis. | P N Levett | Clin Microbiol Rev | 2001 | 11292640 | No |
1459 | 1582 | 1582.0 | 57.66 | 57.7 | Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. | P Holzer | Pharmacol Rev | 1991 | 1852779 | No |
1460 | 1581 | 1581.0 | 45.66 | 45.7 | Ionic dependence of glutamate neurotoxicity. | D W Choi | J Neurosci | 1987 | 2880938 | Yes |
1461 | 1581 | 1581.0 | 62.43 | 62.4 | Modeling and variable selection in epidemiologic analysis. | S Greenland | Am J Public Health | 1989 | 2916724 | Yes |
1462 | 3161 | 1580.5 | 0.0 | 0.0 | Convergent and discriminant validation by the multitrait-multimethod matrix. | D T Campbell, D W Fiske | Psychol Bull | 1959 | 13634291 | Yes |
1463 | 3159 | 1579.5 | 78.35 | 39.2 | A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. | S Tabor, C C Richardson | Proc Natl Acad Sci U S A | 1985 | 3156376 | Yes |
1464 | 3159 | 1579.5 | 68.21 | 34.1 | Inhibitors of mammalian G1 cyclin-dependent kinases. | C J Sherr, J M Roberts | Genes Dev | 1995 | 7758941 | No |
1465 | 3159 | 1579.5 | 78.12 | 39.1 | Neuronal oscillations in cortical networks. | György Buzsáki, Andreas Draguhn | Science | 2004 | 15218136 | No |
1466 | 4738 | 1579.3 | 105.02 | 35.0 | Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. | J E Darnell, I M Kerr, G R Stark | Science | 1994 | 8197455 | No |
1467 | 4737 | 1579.0 | 102.75 | 34.2 | A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. | Zhang, Chung, Oldenburg | J Biomol Screen | 1999 | 10838414 | Yes |
1468 | 1579 | 1579.0 | 44.78 | 44.8 | Oxidative stress and neurodegeneration: where are we now? | Barry Halliwell | J Neurochem | 2006 | 16805774 | No |
1469 | 1579 | 1579.0 | 39.81 | 39.8 | Tumor angiogenesis. | Robert S Kerbel | N Engl J Med | 2008 | 18463380 | No |
1470 | 3157 | 1578.5 | 106.05 | 53.0 | Understanding interobserver agreement: the kappa statistic. | Anthony J Viera, Joanne M Garrett | Fam Med | 2005 | 15883903 | Yes |
1471 | 1577 | 1577.0 | 0.0 | 0.0 | Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. | B Hille | J Gen Physiol | 1977 | 300786 | Yes |
1472 | 1577 | 1577.0 | 33.45 | 33.5 | Points of control in inflammation. | Carl Nathan | Nature | 2002 | 12490957 | No |
1473 | 1577 | 1577.0 | 32.73 | 32.7 | Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. | Judith Campisi | Cell | 2005 | 15734683 | No |
1474 | 1576 | 1576.0 | 72.16 | 72.2 | Mood and memory. | G H Bower | Am Psychol | 1981 | 7224324 | Yes |
1475 | 1576 | 1576.0 | 42.63 | 42.6 | From sensation to cognition. | M M Mesulam | Brain | 1998 | 9648540 | No |
1476 | 4728 | 1576.0 | 133.13 | 44.4 | The metabolic syndrome--a new worldwide definition. | K George M M Alberti, Paul Zimmet, Jonathan Shaw | Lancet | 2005 | 16182882 | Yes |
1477 | 3149 | 1574.5 | 88.87 | 44.4 | Polyamines. | C W Tabor, H Tabor | Annu Rev Biochem | 1984 | 6206782 | No |
1478 | 1574 | 1574.0 | 55.69 | 55.7 | Frontal-subcortical circuits and human behavior. | J L Cummings | Arch Neurol | 1993 | 8352676 | No |
1479 | 1574 | 1574.0 | 31.71 | 31.7 | Generating samples under a Wright-Fisher neutral model of genetic variation. | Richard R Hudson | Bioinformatics | 2002 | 11847089 | Yes |
1480 | 3147 | 1573.5 | 91.98 | 46.0 | Event-related EEG/MEG synchronization and desynchronization: basic principles. | G Pfurtscheller, F H Lopes da Silva | Clin Neurophysiol | 1999 | 10576479 | No |
1481 | 3147 | 1573.5 | 73.96 | 37.0 | Issues and challenges facing rechargeable lithium batteries. | J M Tarascon, M Armand | Nature | 2001 | 11713543 | Yes |
1482 | 1573 | 1573.0 | 0.0 | 0.0 | Regulation of noradrenaline release by presynaptic receptor systems. | K Starke | Rev Physiol Biochem Pharmacol | 1977 | 14389 | No |
1483 | 1572 | 1572.0 | 0.0 | 0.0 | The relationship between the spleen colony-forming cell and the haemopoietic stem cell. | R Schofield | Blood Cells | 1978 | 747780 | Yes |
1484 | 1572 | 1572.0 | 47.08 | 47.1 | Multiple imputation: a primer. | J L Schafer | Stat Methods Med Res | 1999 | 10347857 | No |
1485 | 1571 | 1571.0 | 0.0 | 0.0 | Fluorescence energy transfer as a spectroscopic ruler. | L Stryer | Annu Rev Biochem | 1978 | 354506 | No |
1486 | 1571 | 1571.0 | 52.4 | 52.4 | Biology of interleukin 1. | C A Dinarello | FASEB J | 1988 | 3277884 | No |
1487 | 3140 | 1570.0 | 95.11 | 47.6 | Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. | M Karas, F Hillenkamp | Anal Chem | 1988 | 3239801 | Yes |
1488 | 1570 | 1570.0 | 67.73 | 67.7 | The drug abuse screening test. | H A Skinner | Addict Behav | 1982 | 7183189 | Yes |
1489 | 3138 | 1569.0 | 97.61 | 48.8 | Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. | D S Bredt, S H Snyder | Proc Natl Acad Sci U S A | 1990 | 1689048 | Yes |
1490 | 1569 | 1569.0 | 34.54 | 34.5 | On finding all suboptimal foldings of an RNA molecule. | M Zuker | Science | 1989 | 2468181 | No |
1491 | 1569 | 1569.0 | 51.04 | 51.0 | The stress response in fish. | S E Wendelaar Bonga | Physiol Rev | 1997 | 9234959 | No |
1492 | 1568 | 1568.0 | 61.1 | 61.1 | Simple proton spectroscopic imaging. | W T Dixon | Radiology | 1984 | 6089263 | Yes |
1493 | 1568 | 1568.0 | 30.83 | 30.8 | Switching and signaling at the telomere. | E H Blackburn | Cell | 2001 | 11572773 | No |
1494 | 3134 | 1567.0 | 208.11 | 104.1 | A clinical method of functional assessment of the shoulder. | C R Constant, A H Murley | Clin Orthop Relat Res | 1987 | 3791738 | Yes |
1495 | 1567 | 1567.0 | 30.12 | 30.1 | Germinal centers. | I C MacLennan | Annu Rev Immunol | 1994 | 8011279 | No |
1496 | 4701 | 1567.0 | 190.08 | 63.4 | The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. | C A McHorney, J E Ware, A E Raczek | Med Care | 1993 | 8450681 | Yes |
1497 | 1567 | 1567.0 | 60.54 | 60.5 | Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. | Lutz Ackermann | Chem Rev | 2011 | 21391562 | Yes |
1498 | 1566 | 1566.0 | 0.0 | 0.0 | Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. | W H Oldendorf | Am J Physiol | 1971 | 5124307 | Yes |
1499 | 3130 | 1565.0 | 123.62 | 61.8 | The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. | A J Stunkard, S Messick | J Psychosom Res | 1985 | 3981480 | Yes |
1500 | 1565 | 1565.0 | 0.0 | 0.0 | The estimation of phosphorus. | R J Allen | Biochem J | 1940 | 16747230 | Yes |
1501 | 1565 | 1565.0 | 38.65 | 38.6 | The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. | Michael R Lieber | Annu Rev Biochem | 2010 | 20192759 | No |
1502 | 4693 | 1564.3 | 106.65 | 35.6 | An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. | J K Eng, A L McCormack, J R Yates | J Am Soc Mass Spectrom | 1994 | 24226387 | Yes |
1503 | 1564 | 1564.0 | 52.91 | 52.9 | Archaea in coastal marine environments. | E F DeLong | Proc Natl Acad Sci U S A | 1992 | 1608980 | Yes |
1504 | 1564 | 1564.0 | 40.04 | 40.0 | Cellular basis of working memory. | P S Goldman-Rakic | Neuron | 1995 | 7695894 | No |
1505 | 3127 | 1563.5 | 115.13 | 57.6 | ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. | M Gardes, T D Bruns | Mol Ecol | 1993 | 8180733 | Yes |
1506 | 3126 | 1563.0 | 66.58 | 33.3 | A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. | D Wessel, U I Flügge | Anal Biochem | 1984 | 6731838 | Yes |
1507 | 1563 | 1563.0 | 35.84 | 35.8 | The proto-oncogene Bcl-2 and its role in regulating apoptosis. | G Kroemer | Nat Med | 1997 | 9176486 | No |
1508 | 3124 | 1562.0 | 110.89 | 55.4 | Macrophage plasticity and polarization: in vivo veritas. | Antonio Sica, Alberto Mantovani | J Clin Invest | 2012 | 22378047 | No |
1509 | 4681 | 1560.3 | 133.87 | 44.6 | Cell death: the significance of apoptosis. | A H Wyllie, J F Kerr, A R Currie | Int Rev Cytol | 1980 | 7014501 | No |
1510 | 1560 | 1560.0 | 49.21 | 49.2 | Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. | F Rousset | Genetics | 1997 | 9093870 | Yes |
1511 | 1560 | 1560.0 | 0.0 | 0.0 | A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. | B C Hummel | Can J Biochem Physiol | 1959 | 14405350 | Yes |
1512 | 1559 | 1559.0 | 40.54 | 40.5 | Molecular biology of prion diseases. | S B Prusiner | Science | 1991 | 1675487 | No |
1513 | 1559 | 1559.0 | 42.95 | 43.0 | The complete general secretory pathway in gram-negative bacteria. | A P Pugsley | Microbiol Rev | 1993 | 8096622 | No |
1514 | 1559 | 1559.0 | 51.42 | 51.4 | Health consequences of obesity in youth: childhood predictors of adult disease. | W H Dietz | Pediatrics | 1998 | 12224658 | No |
1515 | 1557 | 1557.0 | 0.0 | 0.0 | Discharge patterns and functional organization of mammalian retina. | S W Kuffler | J Neurophysiol | 1953 | 13035466 | Yes |
1516 | 6228 | 1557.0 | 296.96 | 74.2 | jModelTest 2: more models, new heuristics and parallel computing. | Diego Darriba, Guillermo L Taboada, Ramón Doallo, David Posada | Nat Methods | 2012 | 22847109 | Yes |
1517 | 3110 | 1555.0 | 117.64 | 58.8 | Shifting the genomic gold standard for the prokaryotic species definition. | Michael Richter, Ramon Rosselló-Móra | Proc Natl Acad Sci U S A | 2009 | 19855009 | Yes |
1518 | 1553 | 1553.0 | 45.2 | 45.2 | Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. | S Hakomori | Annu Rev Biochem | 1981 | 7023369 | No |
1519 | 1553 | 1553.0 | 41.96 | 42.0 | Molecular bases of the acute coronary syndromes. | P Libby | Circulation | 1995 | 7758192 | No |
1520 | 1553 | 1553.0 | 34.22 | 34.2 | Neuronal calcium signaling. | M J Berridge | Neuron | 1998 | 9697848 | No |
1521 | 1553 | 1553.0 | 53.45 | 53.5 | Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. | Leonardo Pantoni | Lancet Neurol | 2010 | 20610345 | No |
1522 | 3106 | 1553.0 | 96.17 | 48.1 | Autophagy: renovation of cells and tissues. | Noboru Mizushima, Masaaki Komatsu | Cell | 2011 | 22078875 | No |
1523 | 1551 | 1551.0 | 45.52 | 45.5 | The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. | R R Llinás | Science | 1988 | 3059497 | No |
1524 | 1551 | 1551.0 | 50.32 | 50.3 | Cellular defenses against damage from reactive oxygen species. | B P Yu | Physiol Rev | 1994 | 8295932 | No |
1525 | 1550 | 1550.0 | 44.42 | 44.4 | Determination of minimum inhibitory concentrations. | J M Andrews | J Antimicrob Chemother | 2001 | 11420333 | Yes |
1526 | 4647 | 1549.0 | 0.0 | 0.0 | Impact of Event Scale: a measure of subjective stress. | M Horowitz, N Wilner, W Alvarez | Psychosom Med | 1979 | 472086 | Yes |
1527 | 1549 | 1549.0 | 60.43 | 60.4 | Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. | P Holzer | Neuroscience | 1988 | 3288903 | No |
1528 | 4647 | 1549.0 | 0.0 | 0.0 | A highly sensitive adenylate cyclase assay. | Y Salomon, C Londos, M Rodbell | Anal Biochem | 1974 | 4827395 | Yes |
1529 | 3097 | 1548.5 | 91.02 | 45.5 | Oxidative stress, glutamate, and neurodegenerative disorders. | J T Coyle, P Puttfarcken | Science | 1993 | 7901908 | No |
1530 | 1548 | 1548.0 | 38.49 | 38.5 | Python: a programming language for software integration and development. | M F Sanner | J Mol Graph Model | 1999 | 10660911 | Yes |
1531 | 1546 | 1546.0 | 41.33 | 41.3 | Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. | D A Dougherty | Science | 1996 | 8539615 | No |
1532 | 1546 | 1546.0 | 45.37 | 45.4 | Trail Making Test A and B: normative data stratified by age and education. | Tom N Tombaugh | Arch Clin Neuropsychol | 2004 | 15010086 | Yes |
1533 | 12366 | 1545.8 | 325.17 | 40.6 | Electric field effect in atomically thin carbon films. | K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A Firsov | Science | 2004 | 15499015 | Yes |
1534 | 1545 | 1545.0 | 51.43 | 51.4 | Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). | M N Marsh | Gastroenterology | 1992 | 1727768 | No |
1535 | 3089 | 1544.5 | 71.74 | 35.9 | The epigenomics of cancer. | Peter A Jones, Stephen B Baylin | Cell | 2007 | 17320506 | No |
1536 | 3089 | 1544.5 | 0.0 | 0.0 | A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. | G Schmidt, S J Thannhauser | J Biol Chem | 1945 | 21005717 | Yes |
1537 | 1544 | 1544.0 | 45.09 | 45.1 | The in vitro micronucleus technique. | M Fenech | Mutat Res | 2000 | 11113469 | No |
1538 | 1544 | 1544.0 | 27.58 | 27.6 | Cell cycle checkpoint signaling through the ATM and ATR kinases. | R T Abraham | Genes Dev | 2001 | 11544175 | No |
1539 | 1544 | 1544.0 | 78.04 | 78.0 | Statistics corner: A guide to appropriate use of correlation coefficient in medical research. | M M Mukaka | Malawi Med J | 2012 | 23638278 | Yes |
1540 | 1543 | 1543.0 | 38.08 | 38.1 | HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. | J M Coffin | Science | 1995 | 7824947 | Yes |
1541 | 1543 | 1543.0 | 44.88 | 44.9 | Oxidative stress: oxidants and antioxidants. | H Sies | Exp Physiol | 1997 | 9129943 | No |
1542 | 1543 | 1543.0 | 51.88 | 51.9 | A new automated colorimetric method for measuring total oxidant status. | Ozcan Erel | Clin Biochem | 2005 | 16214125 | Yes |
1543 | 3085 | 1542.5 | 0.0 | 0.0 | The structure of coping. | L I Pearlin, C Schooler | J Health Soc Behav | 1978 | 649936 | Yes |
1544 | 1542 | 1542.0 | 38.94 | 38.9 | Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. | Z Yang | J Mol Evol | 1994 | 7932792 | Yes |
1545 | 4624 | 1541.3 | 118.1 | 39.4 | Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. | Earl S Ford, Wayne H Giles, William H Dietz | JAMA | 2002 | 11790215 | Yes |
1546 | 1541 | 1541.0 | 39.49 | 39.5 | Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. | M J Meaney | Annu Rev Neurosci | 2001 | 11520931 | No |
1547 | 1541 | 1541.0 | 45.09 | 45.1 | Molecular dissection of reactive astrogliosis and glial scar formation. | Michael V Sofroniew | Trends Neurosci | 2009 | 19782411 | No |
1548 | 4621 | 1540.3 | 103.86 | 34.6 | Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. | M A Frohman, M K Dush, G R Martin | Proc Natl Acad Sci U S A | 1988 | 2461560 | Yes |
1549 | 1540 | 1540.0 | 36.54 | 36.5 | AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. | D Grahame Hardie | Nat Rev Mol Cell Biol | 2007 | 17712357 | No |
1550 | 9238 | 1539.7 | 218.49 | 36.4 | Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. | D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuire | Science | 1987 | 3798106 | Yes |
1551 | 3075 | 1537.5 | 75.48 | 37.7 | The DNA-damage response in human biology and disease. | Stephen P Jackson, Jiri Bartek | Nature | 2009 | 19847258 | No |
1552 | 1537 | 1537.0 | 34.69 | 34.7 | Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. | C Taswell | J Immunol | 1981 | 7009746 | Yes |
1553 | 1536 | 1536.0 | 41.99 | 42.0 | THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. | Kozi Asada | Annu Rev Plant Physiol Plant Mol Biol | 1999 | 15012221 | Yes |
1554 | 3072 | 1536.0 | 80.6 | 40.3 | Origins and Mechanisms of miRNAs and siRNAs. | Richard W Carthew, Erik J Sontheimer | Cell | 2009 | 19239886 | No |
1555 | 7677 | 1535.4 | 192.14 | 38.4 | Development and testing of a general amber force field. | Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A Case | J Comput Chem | 2004 | 15116359 | Yes |
1556 | 9212 | 1535.3 | 195.16 | 32.5 | Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. | A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C Mello | Nature | 1998 | 9486653 | Yes |
1557 | 1535 | 1535.0 | 0.0 | 0.0 | Antigen-Antibody Crossed Electrophoresis. | C B Laurell | Anal Biochem | 1965 | 14302464 | Yes |
1558 | 3066 | 1533.0 | 0.0 | 0.0 | Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. | C B Lozzio, B B Lozzio | Blood | 1975 | 163658 | Yes |
1559 | 1533 | 1533.0 | 0.0 | 0.0 | Dithiothreitol, A New Protective Reagent For Sh Groups. | W W Cleland | Biochemistry | 1964 | 14192894 | Yes |
1560 | 1532 | 1532.0 | 44.54 | 44.5 | Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. | A E Pegg | Cancer Res | 1988 | 3123052 | No |
1561 | 1532 | 1532.0 | 0.0 | 0.0 | The inverse care law. | J T Hart | Lancet | 1971 | 4100731 | Yes |
1562 | 1532 | 1532.0 | 37.69 | 37.7 | The retinal pigment epithelium in visual function. | Olaf Strauss | Physiol Rev | 2005 | 15987797 | No |
1563 | 1531 | 1531.0 | 39.07 | 39.1 | Early signals in the mitogenic response. | E Rozengurt | Science | 1986 | 3018928 | No |
1564 | 4591 | 1530.3 | 124.16 | 41.4 | Median-joining networks for inferring intraspecific phylogenies. | H J Bandelt, P Forster, A Röhl | Mol Biol Evol | 1999 | 10331250 | Yes |
1565 | 9176 | 1529.3 | 285.32 | 47.6 | Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. | Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E Walters | Arch Gen Psychiatry | 2005 | 15939837 | Yes |
1566 | 3058 | 1529.0 | 101.15 | 50.6 | Separate visual pathways for perception and action. | M A Goodale, A D Milner | Trends Neurosci | 1992 | 1374953 | No |
1567 | 3058 | 1529.0 | 103.74 | 51.9 | The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. | R Doll, R Peto | J Natl Cancer Inst | 1981 | 7017215 | No |
1568 | 1528 | 1528.0 | 0.0 | 0.0 | Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. | H S Penefsky | J Biol Chem | 1977 | 16006 | Yes |
1569 | 1528 | 1528.0 | 34.36 | 34.4 | Molecular themes in oncogenesis. | J M Bishop | Cell | 1991 | 1988146 | No |
1570 | 1528 | 1528.0 | 0.0 | 0.0 | An enzymic method for the trace iodination of immunoglobulins and other proteins. | J J Marchalonis | Biochem J | 1969 | 4185494 | Yes |
1571 | 1528 | 1528.0 | 45.39 | 45.4 | Porous scaffold design for tissue engineering. | Scott J Hollister | Nat Mater | 2005 | 16003400 | No |
1572 | 1527 | 1527.0 | 70.48 | 70.5 | The contribution of low birth weight to infant mortality and childhood morbidity. | M C McCormick | N Engl J Med | 1985 | 3880598 | No |
1573 | 3054 | 1527.0 | 0.0 | 0.0 | New Giemsa method for the differential staining of sister chromatids. | P Perry, S Wolff | Nature | 1974 | 4138930 | Yes |
1574 | 6108 | 1527.0 | 232.24 | 58.1 | SignalP 4.0: discriminating signal peptides from transmembrane regions. | Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik Nielsen | Nat Methods | 2011 | 21959131 | Yes |
1575 | 1526 | 1526.0 | 30.7 | 30.7 | E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. | J R Nevins | Science | 1992 | 1411535 | Yes |
1576 | 1526 | 1526.0 | 70.85 | 70.8 | Measurement of health state utilities for economic appraisal. | G W Torrance | J Health Econ | 1986 | 10311607 | No |
1577 | 6102 | 1525.5 | 301.22 | 75.3 | The Satisfaction With Life Scale. | E Diener, R A Emmons, R J Larsen, S Griffin | J Pers Assess | 1985 | 16367493 | Yes |
1578 | 1525 | 1525.0 | 27.99 | 28.0 | Altering the genome by homologous recombination. | M R Capecchi | Science | 1989 | 2660260 | No |
1579 | 1525 | 1525.0 | 66.46 | 66.5 | A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. | D J Schuirmann | J Pharmacokinet Biopharm | 1987 | 3450848 | Yes |
1580 | 9150 | 1525.0 | 318.2 | 53.0 | Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. | L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R Tannenbaum | Anal Biochem | 1982 | 7181105 | Yes |
1581 | 1525 | 1525.0 | 36.49 | 36.5 | Getting formal with dopamine and reward. | Wolfram Schultz | Neuron | 2002 | 12383780 | No |
1582 | 3050 | 1525.0 | 64.42 | 32.2 | Upstream and downstream of mTOR. | Nissim Hay, Nahum Sonenberg | Genes Dev | 2004 | 15314020 | No |
1583 | 1525 | 1525.0 | 36.02 | 36.0 | Trastuzumab--mechanism of action and use in clinical practice. | Clifford A Hudis | N Engl J Med | 2007 | 17611206 | No |
1584 | 3049 | 1524.5 | 159.56 | 79.8 | Interrater reliability of a modified Ashworth scale of muscle spasticity. | R W Bohannon, M B Smith | Phys Ther | 1987 | 3809245 | Yes |
1585 | 1524 | 1524.0 | 0.0 | 0.0 | Statistical analysis of enzyme kinetic data. | W W Cleland | Methods Enzymol | 1979 | 502857 | Yes |
1586 | 1524 | 1524.0 | 45.42 | 45.4 | Recent advances in the biochemistry of polyamines in eukaryotes. | A E Pegg | Biochem J | 1986 | 3087344 | No |
1587 | 1524 | 1524.0 | 39.18 | 39.2 | Growth of the plant cell wall. | Daniel J Cosgrove | Nat Rev Mol Cell Biol | 2005 | 16261190 | No |
1588 | 1524 | 1524.0 | 46.51 | 46.5 | Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. | Ralph A Defronzo | Diabetes | 2009 | 19336687 | No |
1589 | 1522 | 1522.0 | 0.0 | 0.0 | Which elements are excited in electrical stimulation of mammalian central nervous system: a review. | J B Ranck | Brain Res | 1975 | 1102064 | No |
1590 | 1521 | 1521.0 | 0.0 | 0.0 | Synaptic density in human frontal cortex - developmental changes and effects of aging. | P R Huttenlocher | Brain Res | 1979 | 427544 | Yes |
1591 | 1518 | 1518.0 | 41.57 | 41.6 | Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. | L A Liotta | Cancer Res | 1986 | 2998604 | No |
1592 | 1518 | 1518.0 | 57.29 | 57.3 | Aging, natural death, and the compression of morbidity. | J F Fries | N Engl J Med | 1980 | 7383070 | Yes |
1593 | 1518 | 1518.0 | 29.18 | 29.2 | How cells read TGF-beta signals. | J Massagué | Nat Rev Mol Cell Biol | 2000 | 11252892 | No |
1594 | 7590 | 1518.0 | 200.01 | 40.0 | Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. | Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan Hsu | N Engl J Med | 2004 | 15385656 | Yes |
1595 | 1517 | 1517.0 | 0.0 | 0.0 | Calcium release from the sarcoplasmic reticulum. | M Endo | Physiol Rev | 1977 | 13441 | Yes |
1596 | 3034 | 1517.0 | 0.0 | 0.0 | Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. | D B Dill, D L Costill | J Appl Physiol | 1974 | 4850854 | Yes |
1597 | 3034 | 1517.0 | 65.69 | 32.8 | Signaling to NF-kappaB. | Matthew S Hayden, Sankar Ghosh | Genes Dev | 2004 | 15371334 | No |
1598 | 3034 | 1517.0 | 67.72 | 33.9 | Why do cancers have high aerobic glycolysis? | Robert A Gatenby, Robert J Gillies | Nat Rev Cancer | 2004 | 15516961 | No |
1599 | 3033 | 1516.5 | 60.31 | 30.2 | Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. | O Tetsu, F McCormick | Nature | 1999 | 10201372 | Yes |
1600 | 1516 | 1516.0 | 30.2 | 30.2 | Neuroblastoma: biological insights into a clinical enigma. | Garrett M Brodeur | Nat Rev Cancer | 2003 | 12612655 | No |
1601 | 3031 | 1515.5 | 0.0 | 0.0 | Computed circular dichroism spectra for the evaluation of protein conformation. | N Greenfield, G D Fasman | Biochemistry | 1969 | 5346390 | Yes |
1602 | 16668 | 1515.3 | 448.92 | 40.8 | PLINK: a tool set for whole-genome association and population-based linkage analyses. | Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C Sham | Am J Hum Genet | 2007 | 17701901 | Yes |
1603 | 1514 | 1514.0 | 59.91 | 59.9 | Probiotics in man and animals. | R Fuller | J Appl Bacteriol | 1989 | 2666378 | No |
1604 | 1514 | 1514.0 | 56.62 | 56.6 | The linear-quadratic formula and progress in fractionated radiotherapy. | J F Fowler | Br J Radiol | 1989 | 2670032 | No |
1605 | 3028 | 1514.0 | 74.61 | 37.3 | Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. | Robert Visse, Hideaki Nagase | Circ Res | 2003 | 12730128 | No |
1606 | 1514 | 1514.0 | 36.5 | 36.5 | Thiazolidinediones. | Hannele Yki-Järvinen | N Engl J Med | 2004 | 15356308 | No |
1607 | 1513 | 1513.0 | 44.56 | 44.6 | The basal ganglia: focused selection and inhibition of competing motor programs. | J W Mink | Prog Neurobiol | 1996 | 9004351 | No |
1608 | 1513 | 1513.0 | 44.4 | 44.4 | What we can do and what we cannot do with fMRI. | Nikos K Logothetis | Nature | 2008 | 18548064 | No |
1609 | 3024 | 1512.0 | 76.33 | 38.2 | The BCL-2 protein family: opposing activities that mediate cell death. | Richard J Youle, Andreas Strasser | Nat Rev Mol Cell Biol | 2008 | 18097445 | No |
1610 | 3023 | 1511.5 | 70.02 | 35.0 | Fibroblasts in cancer. | Raghu Kalluri, Michael Zeisberg | Nat Rev Cancer | 2006 | 16572188 | No |
1611 | 1511 | 1511.0 | 0.0 | 0.0 | Biological applications of ionophores. | B C Pressman | Annu Rev Biochem | 1976 | 786156 | No |
1612 | 1510 | 1510.0 | 0.0 | 0.0 | Some observations upon a new inhibitor of monoamine oxidase in brain tissue. | J P Johnston | Biochem Pharmacol | 1968 | 5659776 | Yes |
1613 | 1509 | 1509.0 | 31.0 | 31.0 | Network motifs: theory and experimental approaches. | Uri Alon | Nat Rev Genet | 2007 | 17510665 | No |
1614 | 6034 | 1508.5 | 205.89 | 51.5 | clusterProfiler: an R package for comparing biological themes among gene clusters. | Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu He | OMICS | 2012 | 22455463 | Yes |
1615 | 1508 | 1508.0 | 47.67 | 47.7 | The role of the amygdala in fear and anxiety. | M Davis | Annu Rev Neurosci | 1992 | 1575447 | No |
1616 | 3013 | 1506.5 | 100.86 | 50.4 | Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. | Stephen M Smith, Thomas E Nichols | Neuroimage | 2009 | 18501637 | Yes |
1617 | 1506 | 1506.0 | 38.17 | 38.2 | Trophic factors and neuronal survival. | Y A Barde | Neuron | 1989 | 2697237 | No |
1618 | 6020 | 1505.0 | 0.0 | 0.0 | The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. | S P Baker, B O'Neill, W Haddon, W B Long | J Trauma | 1974 | 4814394 | Yes |
1619 | 1505 | 1505.0 | 30.99 | 31.0 | The ubiquitin-proteasome proteolytic pathway. | A Ciechanover | Cell | 1994 | 7923371 | No |
1620 | 1504 | 1504.0 | 42.29 | 42.3 | Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. | Y Ben-Ari | Neuroscience | 1985 | 2859548 | No |
1621 | 1504 | 1504.0 | 37.14 | 37.1 | Recognition of errors in three-dimensional structures of proteins. | M J Sippl | Proteins | 1993 | 8108378 | Yes |
1622 | 1504 | 1504.0 | 33.65 | 33.6 | Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. | G L Semenza | Annu Rev Cell Dev Biol | 1999 | 10611972 | No |
1623 | 1504 | 1504.0 | 35.51 | 35.5 | Hypertrophic cardiomyopathy: a systematic review. | Barry J Maron | JAMA | 2002 | 11886323 | No |
1624 | 1504 | 1504.0 | 0.0 | 0.0 | Cognitive maps in rats and men. | E C Tolman | Psychol Rev | 1948 | 18870876 | Yes |
1625 | 3005 | 1502.5 | 73.18 | 36.6 | Human mesenchymal stem cells modulate allogeneic immune cell responses. | Sudeepta Aggarwal, Mark F Pittenger | Blood | 2005 | 15494428 | Yes |
1626 | 1502 | 1502.0 | 38.4 | 38.4 | The corticosteroid receptor hypothesis of depression. | F Holsboer | Neuropsychopharmacology | 2000 | 11027914 | No |
1627 | 1502 | 1502.0 | 30.46 | 30.5 | The microRNA Registry. | Sam Griffiths-Jones | Nucleic Acids Res | 2004 | 14681370 | Yes |
1628 | 1499 | 1499.0 | 36.06 | 36.1 | Introduction to NF-kappaB: players, pathways, perspectives. | T D Gilmore | Oncogene | 2006 | 17072321 | No |
1629 | 1499 | 1499.0 | 38.66 | 38.7 | Tricine-SDS-PAGE. | Hermann Schägger | Nat Protoc | 2006 | 17406207 | Yes |
1630 | 4497 | 1499.0 | 117.77 | 39.3 | Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. | Prateek Kumar, Steven Henikoff, Pauline C Ng | Nat Protoc | 2009 | 19561590 | Yes |
1631 | 1498 | 1498.0 | 0.0 | 0.0 | The recurrence of intracranial meningiomas after surgical treatment. | D Simpson | J Neurol Neurosurg Psychiatry | 1957 | 13406590 | Yes |
1632 | 1497 | 1497.0 | 32.3 | 32.3 | Oxidative stress shortens telomeres. | Thomas von Zglinicki | Trends Biochem Sci | 2002 | 12114022 | Yes |
1633 | 7481 | 1496.2 | 172.43 | 34.5 | Stages of embryonic development of the zebrafish. | C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F Schilling | Dev Dyn | 1995 | 8589427 | Yes |
1634 | 1496 | 1496.0 | 36.62 | 36.6 | A revolution in optical manipulation. | David G Grier | Nature | 2003 | 12917694 | No |
1635 | 1496 | 1496.0 | 36.13 | 36.1 | The hippo signaling pathway in development and cancer. | Duojia Pan | Dev Cell | 2010 | 20951342 | No |
1636 | 13459 | 1495.4 | 491.97 | 54.7 | STAR: ultrafast universal RNA-seq aligner. | Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R Gingeras | Bioinformatics | 2013 | 23104886 | Yes |
1637 | 1495 | 1495.0 | 0.0 | 0.0 | Bias in analytic research. | D L Sackett | J Chronic Dis | 1979 | 447779 | Yes |
1638 | 1495 | 1495.0 | 0.0 | 0.0 | Simple memory: a theory for archicortex. | D Marr | Philos Trans R Soc Lond B Biol Sci | 1971 | 4399412 | Yes |
1639 | 2990 | 1495.0 | 96.27 | 48.1 | Alzheimer's disease. | Henry W Querfurth, Frank M LaFerla | N Engl J Med | 2010 | 20107219 | No |
1640 | 1494 | 1494.0 | 0.0 | 0.0 | Dopamine (3-hydroxytyramine) and brain function. | O Hornykiewicz | Pharmacol Rev | 1966 | 5328389 | No |
1641 | 1494 | 1494.0 | 47.54 | 47.5 | Constructions of masculinity and their influence on men's well-being: a theory of gender and health. | W H Courtenay | Soc Sci Med | 2000 | 10741575 | No |
1642 | 1494 | 1494.0 | 0.0 | 0.0 | Application of a Theory of Enzyme Specificity to Protein Synthesis. | D E Koshland | Proc Natl Acad Sci U S A | 1958 | 16590179 | Yes |
1643 | 1493 | 1493.0 | 39.4 | 39.4 | The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. | A S Fauci | Science | 1988 | 3277274 | No |
1644 | 1493 | 1493.0 | 0.0 | 0.0 | A soluble protein characteristic of the nervous system. | B W Moore | Biochem Biophys Res Commun | 1965 | 4953930 | Yes |
1645 | 1493 | 1493.0 | 46.46 | 46.5 | Gold-catalyzed organic reactions. | A Stephen K Hashmi | Chem Rev | 2007 | 17580975 | Yes |
1646 | 1493 | 1493.0 | 58.37 | 58.4 | Large-scale brain networks and psychopathology: a unifying triple network model. | Vinod Menon | Trends Cogn Sci | 2011 | 21908230 | No |
1647 | 2982 | 1491.0 | 62.68 | 31.3 | Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. | Gary L Johnson, Razvan Lapadat | Science | 2002 | 12471242 | No |
1648 | 2982 | 1491.0 | 98.44 | 49.2 | Molecular mechanisms and clinical applications of angiogenesis. | Peter Carmeliet, Rakesh K Jain | Nature | 2011 | 21593862 | No |
1649 | 4472 | 1490.7 | 153.8 | 51.3 | A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. | J R Le Gall, S Lemeshow, F Saulnier | JAMA | 1993 | 8254858 | Yes |
1650 | 1490 | 1490.0 | 0.0 | 0.0 | Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. | J C Unkeless | J Exp Med | 1979 | 90108 | Yes |
1651 | 2980 | 1490.0 | 73.56 | 36.8 | Shared principles in NF-kappaB signaling. | Matthew S Hayden, Sankar Ghosh | Cell | 2008 | 18267068 | No |
1652 | 4469 | 1489.7 | 90.26 | 30.1 | Efficient selection for high-expression transfectants with a novel eukaryotic vector. | H Niwa, K Yamamura, J Miyazaki | Gene | 1991 | 1660837 | Yes |
1653 | 4465 | 1488.3 | 95.66 | 31.9 | The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. | S K Hanks, A M Quinn, T Hunter | Science | 1988 | 3291115 | No |
1654 | 1488 | 1488.0 | 0.0 | 0.0 | Cerebral blood flow and oxygen consumption in man. | N A Lassen | Physiol Rev | 1959 | 13645234 | Yes |
1655 | 2975 | 1487.5 | 0.0 | 0.0 | Lactic dehydrogenase activity in blood. | F Wroblewski, J S Ladue | Proc Soc Exp Biol Med | 1955 | 13273400 | Yes |
1656 | 1487 | 1487.0 | 0.0 | 0.0 | Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. | S Avrameas | Immunochemistry | 1969 | 4975324 | Yes |
1657 | 1487 | 1487.0 | 41.82 | 41.8 | Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. | A Fabiato | Am J Physiol | 1983 | 6346892 | No |
1658 | 1485 | 1485.0 | 0.0 | 0.0 | Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. | C S Neer | J Bone Joint Surg Am | 1972 | 5054450 | Yes |
1659 | 2969 | 1484.5 | 91.3 | 45.6 | Unified approach for molecular dynamics and density-functional theory. | Car, Parrinello | Phys Rev Lett | 1985 | 10032153 | Yes |
1660 | 1483 | 1483.0 | 52.12 | 52.1 | Lyme disease. | A C Steere | N Engl J Med | 1989 | 2668764 | No |
1661 | 1483 | 1483.0 | 31.94 | 31.9 | DNA in a material world. | Nadrian C Seeman | Nature | 2003 | 12540916 | No |
1662 | 1483 | 1483.0 | 34.98 | 35.0 | Perceptions of epigenetics. | Adrian Bird | Nature | 2007 | 17522671 | Yes |
1663 | 1482 | 1482.0 | 35.38 | 35.4 | A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. | D A Gewirtz | Biochem Pharmacol | 1999 | 10075079 | No |
1664 | 7408 | 1481.6 | 0.0 | 0.0 | Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. | S Katz, A B Ford, R W Moskowitz, B A Jackson, M W Jaffe | JAMA | 1963 | 14044222 | Yes |
1665 | 4444 | 1481.3 | 90.07 | 30.0 | T-Coffee: A novel method for fast and accurate multiple sequence alignment. | C Notredame, D G Higgins, J Heringa | J Mol Biol | 2000 | 10964570 | Yes |
1666 | 1481 | 1481.0 | 0.0 | 0.0 | Simple methods for "staining with lead" at high pH in electron microscopy. | M J Karnovsky | J Biophys Biochem Cytol | 1961 | 14454024 | Yes |
1667 | 1481 | 1481.0 | 40.86 | 40.9 | Pathogen recognition and inflammatory signaling in innate immune defenses. | Trine H Mogensen | Clin Microbiol Rev | 2009 | 19366914 | No |
1668 | 1479 | 1479.0 | 0.0 | 0.0 | Atherogenesis: a postprandial phenomenon. | D B Zilversmit | Circulation | 1979 | 222498 | Yes |
1669 | 1479 | 1479.0 | 33.69 | 33.7 | Tumor suppressor genes. | R A Weinberg | Science | 1991 | 1659741 | No |
1670 | 5913 | 1478.2 | 133.54 | 33.4 | MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. | Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi Miyata | Nucleic Acids Res | 2002 | 12136088 | Yes |
1671 | 1478 | 1478.0 | 0.0 | 0.0 | The colorimetric determination of phosphorus. | E J King | Biochem J | 1932 | 16744823 | Yes |
1672 | 4433 | 1477.7 | 120.05 | 40.0 | A neural substrate of prediction and reward. | W Schultz, P Dayan, P R Montague | Science | 1997 | 9054347 | No |
1673 | 2955 | 1477.5 | 0.0 | 0.0 | Junctional complexes in various epithelia. | M G Farquhar, G E Palade | J Cell Biol | 1963 | 13944428 | Yes |
1674 | 2954 | 1477.0 | 59.48 | 29.7 | Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. | P J Mitchell, R Tjian | Science | 1989 | 2667136 | No |
1675 | 1476 | 1476.0 | 39.93 | 39.9 | Rheumatoid arthritis. Pathophysiology and implications for therapy. | E D Harris | N Engl J Med | 1990 | 2271017 | No |
1676 | 1476 | 1476.0 | 31.63 | 31.6 | Neurotrophins and their receptors: a convergence point for many signalling pathways. | Moses V Chao | Nat Rev Neurosci | 2003 | 12671646 | No |
1677 | 2951 | 1475.5 | 108.67 | 54.3 | The transtheoretical model of health behavior change. | J O Prochaska, W F Velicer | Am J Health Promot | 1997 | 10170434 | No |
1678 | 2950 | 1475.0 | 76.19 | 38.1 | Long short-term memory. | S Hochreiter, J Schmidhuber | Neural Comput | 1997 | 9377276 | Yes |
1679 | 1474 | 1474.0 | 0.0 | 0.0 | Isolated removal of hypothalamic or other brain nuclei of the rat. | M Palkovits | Brain Res | 1973 | 4747772 | Yes |
1680 | 1473 | 1473.0 | 39.78 | 39.8 | Precision mapping of quantitative trait loci. | Z B Zeng | Genetics | 1994 | 8013918 | Yes |
1681 | 1473 | 1473.0 | 0.0 | 0.0 | Impulses and Physiological States in Theoretical Models of Nerve Membrane. | R Fitzhugh | Biophys J | 1961 | 19431309 | Yes |
1682 | 7360 | 1472.0 | 887.81 | 177.6 | MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. | Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro Tamura | Mol Biol Evol | 2018 | 29722887 | Yes |
1683 | 4411 | 1470.3 | 115.66 | 38.6 | The rapid generation of mutation data matrices from protein sequences. | D T Jones, W R Taylor, J M Thornton | Comput Appl Biosci | 1992 | 1633570 | Yes |
1684 | 1470 | 1470.0 | 49.42 | 49.4 | Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. | H J Gundersen | J Microsc | 1986 | 3761363 | Yes |
1685 | 4410 | 1470.0 | 84.73 | 28.2 | Notch signaling: cell fate control and signal integration in development. | S Artavanis-Tsakonas, M D Rand, R J Lake | Science | 1999 | 10221902 | No |
1686 | 4401 | 1467.0 | 151.05 | 50.4 | Phylogenetic identification and in situ detection of individual microbial cells without cultivation. | R I Amann, W Ludwig, K H Schleifer | Microbiol Rev | 1995 | 7535888 | No |
1687 | 1467 | 1467.0 | 33.73 | 33.7 | Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. | M B Luskin | Neuron | 1993 | 8338665 | Yes |
1688 | 2934 | 1467.0 | 66.06 | 33.0 | Cell migration: a physically integrated molecular process. | D A Lauffenburger, A F Horwitz | Cell | 1996 | 8608589 | No |
1689 | 2934 | 1467.0 | 77.99 | 39.0 | Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. | M A Nitsche, W Paulus | J Physiol | 2000 | 10990547 | Yes |
1690 | 1467 | 1467.0 | 25.32 | 25.3 | Neuronal specification in the spinal cord: inductive signals and transcriptional codes. | T M Jessell | Nat Rev Genet | 2000 | 11262869 | No |
1691 | 1466 | 1466.0 | 53.06 | 53.1 | Cognitive reserve. | Yaakov Stern | Neuropsychologia | 2009 | 19467352 | No |
1692 | 1465 | 1465.0 | 0.0 | 0.0 | Selforganization of matter and the evolution of biological macromolecules. | M Eigen | Naturwissenschaften | 1971 | 4942363 | No |
1693 | 1465 | 1465.0 | 29.1 | 29.1 | Intrinsically unstructured proteins. | Peter Tompa | Trends Biochem Sci | 2002 | 12368089 | No |
1694 | 2930 | 1465.0 | 67.13 | 33.6 | Complex networks orchestrate epithelial-mesenchymal transitions. | Jean Paul Thiery, Jonathan P Sleeman | Nat Rev Mol Cell Biol | 2006 | 16493418 | No |
1695 | 2928 | 1464.0 | 0.0 | 0.0 | A general method for isolation of high molecular weight DNA from eukaryotes. | N Blin, D W Stafford | Nucleic Acids Res | 1976 | 987581 | Yes |
1696 | 1464 | 1464.0 | 37.97 | 38.0 | Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. | Shitij Kapur | Am J Psychiatry | 2003 | 12505794 | No |
1697 | 4391 | 1463.7 | 0.0 | 0.0 | The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. | J T Dodge, C Mitchell, D J Hanahan | Arch Biochem Biophys | 1963 | 14028302 | Yes |
1698 | 2927 | 1463.5 | 113.38 | 56.7 | The mini-mental state examination: a comprehensive review. | T N Tombaugh, N J McIntyre | J Am Geriatr Soc | 1992 | 1512391 | No |
1699 | 1462 | 1462.0 | 39.81 | 39.8 | Redox signaling: nitrosylation and related target interactions of nitric oxide. | J S Stamler | Cell | 1994 | 7923362 | No |
1700 | 1461 | 1461.0 | 0.0 | 0.0 | Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. | R W Sperry | Proc Natl Acad Sci U S A | 1963 | 14077501 | Yes |
1701 | 5842 | 1460.5 | 237.36 | 59.3 | 16S ribosomal DNA amplification for phylogenetic study. | W G Weisburg, S M Barns, D A Pelletier, D J Lane | J Bacteriol | 1991 | 1987160 | Yes |
1702 | 1460 | 1460.0 | 40.85 | 40.9 | Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. | J A Beavo | Physiol Rev | 1995 | 7480160 | No |
1703 | 2920 | 1460.0 | 70.69 | 35.3 | The incidence of congenital heart disease. | Julien I E Hoffman, Samuel Kaplan | J Am Coll Cardiol | 2002 | 12084585 | No |
1704 | 1460 | 1460.0 | 29.14 | 29.1 | Protein kinases--the major drug targets of the twenty-first century? | Philip Cohen | Nat Rev Drug Discov | 2002 | 12120282 | No |
1705 | 1460 | 1460.0 | 35.62 | 35.6 | Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). | K M Fox | Lancet | 2003 | 13678872 | Yes |
1706 | 2920 | 1460.0 | 104.69 | 52.3 | Palladium-catalyzed ligand-directed C-H functionalization reactions. | Thomas W Lyons, Melanie S Sanford | Chem Rev | 2010 | 20078038 | No |
1707 | 1460 | 1460.0 | 68.16 | 68.2 | Gctf: Real-time CTF determination and correction. | Kai Zhang | J Struct Biol | 2016 | 26592709 | Yes |
1708 | 2919 | 1459.5 | 0.0 | 0.0 | Diabetes and cardiovascular disease. The Framingham study. | W B Kannel, D L McGee | JAMA | 1979 | 430798 | Yes |
1709 | 2919 | 1459.5 | 0.0 | 0.0 | A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. | A H Anton, D F Sayre | J Pharmacol Exp Ther | 1962 | 14013351 | Yes |
1710 | 1459 | 1459.0 | 0.0 | 0.0 | The mechanism of muscular contraction. | H E Huxley | Science | 1969 | 4181952 | No |
1711 | 2918 | 1459.0 | 83.82 | 41.9 | Diarrheagenic Escherichia coli. | J P Nataro, J B Kaper | Clin Microbiol Rev | 1998 | 9457432 | No |
1712 | 1459 | 1459.0 | 42.3 | 42.3 | Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. | P A Bradford | Clin Microbiol Rev | 2001 | 11585791 | No |
1713 | 1459 | 1459.0 | 52.19 | 52.2 | Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. | Berislav V Zlokovic | Nat Rev Neurosci | 2011 | 22048062 | No |
1714 | 5833 | 1458.2 | 0.0 | 0.0 | A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. | M A Markwell, S M Haas, L L Bieber, N E Tolbert | Anal Biochem | 1978 | 98070 | Yes |
1715 | 4374 | 1458.0 | 0.0 | 0.0 | Hydroperoxide metabolism in mammalian organs. | B Chance, H Sies, A Boveris | Physiol Rev | 1979 | 37532 | Yes |
1716 | 1458 | 1458.0 | 0.0 | 0.0 | The Gingival Index, the Plaque Index and the Retention Index Systems. | H Löe | J Periodontol | 1967 | 5237684 | Yes |
1717 | 1458 | 1458.0 | 31.66 | 31.7 | Drug discovery: a historical perspective. | J Drews | Science | 2000 | 10720314 | No |
1718 | 1458 | 1458.0 | 32.13 | 32.1 | From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. | W A Catterall | Neuron | 2000 | 10798388 | No |
1719 | 2916 | 1458.0 | 60.23 | 30.1 | NF-kappaB regulation in the immune system. | Qiutang Li, Inder M Verma | Nat Rev Immunol | 2002 | 12360211 | No |
1720 | 1458 | 1458.0 | 0.0 | 0.0 | Nutrition needs of mammalian cells in tissue culture. | H Eagle | Science | 1955 | 13255879 | Yes |
1721 | 1457 | 1457.0 | 29.14 | 29.1 | Protein degradation and protection against misfolded or damaged proteins. | Alfred L Goldberg | Nature | 2003 | 14685250 | No |
1722 | 4369 | 1456.3 | 122.01 | 40.7 | Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. | M Hasegawa, H Kishino, T Yano | J Mol Evol | 1985 | 3934395 | Yes |
1723 | 1455 | 1455.0 | 61.98 | 62.0 | Antibiotics in the aquatic environment--a review--part I. | Klaus Kümmerer | Chemosphere | 2009 | 19185900 | No |
1724 | 2908 | 1454.0 | 80.45 | 40.2 | Angiogenesis. | J Folkman, Y Shing | J Biol Chem | 1992 | 1375931 | No |
1725 | 1454 | 1454.0 | 0.0 | 0.0 | Defective repair replication of DNA in xeroderma pigmentosum. | J E Cleaver | Nature | 1968 | 5655953 | Yes |
1726 | 1454 | 1454.0 | 79.33 | 79.3 | Subjective well-being. | E Diener | Psychol Bull | 1984 | 6399758 | No |
1727 | 1454 | 1454.0 | 46.58 | 46.6 | Evidence for a central component of post-injury pain hypersensitivity. | C J Woolf | Nature | 1983 | 6656869 | Yes |
1728 | 1454 | 1454.0 | 0.0 | 0.0 | Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. | P C Nowell | Cancer Res | 1960 | 14427849 | Yes |
1729 | 1454 | 1454.0 | 0.0 | 0.0 | Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. | I E Bush | Biochem J | 1952 | 14915960 | Yes |
1730 | 2907 | 1453.5 | 86.23 | 43.1 | The precuneus: a review of its functional anatomy and behavioural correlates. | Andrea E Cavanna, Michael R Trimble | Brain | 2006 | 16399806 | No |
1731 | 1453 | 1453.0 | 0.0 | 0.0 | Ionic blockage of sodium channels in nerve. | A M Woodhull | J Gen Physiol | 1973 | 4541078 | Yes |
1732 | 8713 | 1452.2 | 283.91 | 47.3 | Cancer statistics, 2009. | Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J Thun | CA Cancer J Clin | 2009 | 19474385 | Yes |
1733 | 1452 | 1452.0 | 34.24 | 34.2 | PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. | Michael F. Thomashow | Annu Rev Plant Physiol Plant Mol Biol | 1999 | 15012220 | Yes |
1734 | 2903 | 1451.5 | 73.15 | 36.6 | Adipose tissue as an endocrine organ. | Erin E Kershaw, Jeffrey S Flier | J Clin Endocrinol Metab | 2004 | 15181022 | No |
1735 | 2902 | 1451.0 | 68.51 | 34.3 | Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. | C Auffray, F Rougeon | Eur J Biochem | 1980 | 6772444 | Yes |
1736 | 1451 | 1451.0 | 76.88 | 76.9 | The biology and function of fibroblasts in cancer. | Raghu Kalluri | Nat Rev Cancer | 2016 | 27550820 | No |
1737 | 2901 | 1450.5 | 0.0 | 0.0 | Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. | D H Clarke, J Casals | Am J Trop Med Hyg | 1958 | 13571577 | Yes |
1738 | 14501 | 1450.1 | 359.0 | 35.9 | Multilineage potential of adult human mesenchymal stem cells. | M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R Marshak | Science | 1999 | 10102814 | Yes |
1739 | 1450 | 1450.0 | 37.31 | 37.3 | Type I diabetes mellitus. A chronic autoimmune disease. | G S Eisenbarth | N Engl J Med | 1986 | 3517648 | No |
1740 | 1450 | 1450.0 | 0.0 | 0.0 | The organization of proteins in the human red blood cell membrane. A review. | T L Steck | J Cell Biol | 1974 | 4600883 | No |
1741 | 1450 | 1450.0 | 52.48 | 52.5 | Dual-task interference in simple tasks: data and theory. | H Pashler | Psychol Bull | 1994 | 7972591 | No |
1742 | 1450 | 1450.0 | 32.85 | 32.9 | An approximately unbiased test of phylogenetic tree selection. | Hidetoshi Shimodaira | Syst Biol | 2002 | 12079646 | Yes |
1743 | 1450 | 1450.0 | 35.73 | 35.7 | In vivo near-infrared fluorescence imaging. | John V Frangioni | Curr Opin Chem Biol | 2003 | 14580568 | No |
1744 | 1450 | 1450.0 | 0.0 | 0.0 | The free amino groups of insulin. | F Sanger | Biochem J | 1945 | 16747948 | Yes |
1745 | 2896 | 1448.0 | 76.69 | 38.3 | The expanding universe of T-cell subsets: Th1, Th2 and more. | T R Mosmann, S Sad | Immunol Today | 1996 | 8820272 | No |
1746 | 1448 | 1448.0 | 34.37 | 34.4 | Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. | S C Manolagas | Endocr Rev | 2000 | 10782361 | No |
1747 | 1448 | 1448.0 | 0.0 | 0.0 | Starch gel electrophoresis in a discontinous system of buffers. | M D Poulik | Nature | 1957 | 13493570 | Yes |
1748 | 1448 | 1448.0 | 29.56 | 29.6 | Immunosuppressive networks in the tumour environment and their therapeutic relevance. | Weiping Zou | Nat Rev Cancer | 2005 | 15776005 | No |
1749 | 2895 | 1447.5 | 82.53 | 41.3 | Multiple sclerosis. | Alastair Compston, Alasdair Coles | Lancet | 2008 | 18970977 | Yes |
1750 | 1447 | 1447.0 | 43.04 | 43.0 | Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. | M D Maines | FASEB J | 1988 | 3290025 | No |
1751 | 2894 | 1447.0 | 56.02 | 28.0 | The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. | Michael H Glickman, Aaron Ciechanover | Physiol Rev | 2002 | 11917093 | No |
1752 | 5777 | 1444.2 | 0.0 | 0.0 | The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. | L A Sternberger, P H Hardy, J J Cuculis, H G Meyer | J Histochem Cytochem | 1970 | 4192899 | Yes |
1753 | 1444 | 1444.0 | 0.0 | 0.0 | Stimulated acoustic emissions from within the human auditory system. | D T Kemp | J Acoust Soc Am | 1978 | 744838 | Yes |
1754 | 2888 | 1444.0 | 80.31 | 40.2 | A rapid boiling method for the preparation of bacterial plasmids. | D S Holmes, M Quigley | Anal Biochem | 1981 | 6269464 | Yes |
1755 | 2887 | 1443.5 | 61.02 | 30.5 | Toll-like receptor control of the adaptive immune responses. | Akiko Iwasaki, Ruslan Medzhitov | Nat Immunol | 2004 | 15454922 | No |
1756 | 1443 | 1443.0 | 48.58 | 48.6 | Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. | G A McPherson | J Pharmacol Methods | 1985 | 3840547 | Yes |
1757 | 1443 | 1443.0 | 0.0 | 0.0 | Amino acid difference formula to help explain protein evolution. | R Grantham | Science | 1974 | 4843792 | Yes |
1758 | 1443 | 1443.0 | 65.61 | 65.6 | The emerging role of lncRNAs in cancer. | Maite Huarte | Nat Med | 2015 | 26540387 | No |
1759 | 2885 | 1442.5 | 57.47 | 28.7 | Missing pieces in the NF-kappaB puzzle. | Sankar Ghosh, Michael Karin | Cell | 2002 | 11983155 | No |
1760 | 10095 | 1442.1 | 484.24 | 69.2 | limma powers differential expression analyses for RNA-sequencing and microarray studies. | Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth | Nucleic Acids Res | 2015 | 25605792 | Yes |
1761 | 1442 | 1442.0 | 0.0 | 0.0 | Superoxide dismutases. | I Fridovich | Annu Rev Biochem | 1975 | 1094908 | No |
1762 | 1442 | 1442.0 | 48.19 | 48.2 | Validation of a decisional conflict scale. | A M O'Connor | Med Decis Making | 1995 | 7898294 | Yes |
1763 | 1442 | 1442.0 | 33.36 | 33.4 | Mechanisms of bone metastasis. | G David Roodman | N Engl J Med | 2004 | 15084698 | No |
1764 | 2882 | 1441.0 | 0.0 | 0.0 | Mutants of Escherichia coli requiring methionine or vitamin B12. | B D Davis, E S Mingioli | J Bacteriol | 1950 | 15436457 | Yes |
1765 | 5763 | 1440.8 | 118.92 | 29.7 | A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. | B M Bolstad, R A Irizarry, M Astrand, T P Speed | Bioinformatics | 2003 | 12538238 | Yes |
1766 | 2881 | 1440.5 | 75.52 | 37.8 | Empirical threshold values for quantitative trait mapping. | G A Churchill, R W Doerge | Genetics | 1994 | 7851788 | Yes |
1767 | 5761 | 1440.2 | 146.73 | 36.7 | Improved optimization for the robust and accurate linear registration and motion correction of brain images. | Mark Jenkinson, Peter Bannister, Michael Brady, Stephen Smith | Neuroimage | 2002 | 12377157 | Yes |
1768 | 1440 | 1440.0 | 45.42 | 45.4 | Domino Reactions in Organic Synthesis. | Lutz F. Tietze | Chem Rev | 1996 | 11848746 | Yes |
1769 | 2879 | 1439.5 | 0.0 | 0.0 | 3' non-coding region sequences in eukaryotic messenger RNA. | N J Proudfoot, G G Brownlee | Nature | 1976 | 822353 | Yes |
1770 | 2877 | 1438.5 | 0.0 | 0.0 | Assay of proteins in the presence of interfering materials. | A Bensadoun, D Weinstein | Anal Biochem | 1976 | 1259145 | Yes |
1771 | 2875 | 1437.5 | 68.33 | 34.2 | The human plasma proteome: history, character, and diagnostic prospects. | N Leigh Anderson, Norman G Anderson | Mol Cell Proteomics | 2002 | 12488461 | No |
1772 | 2875 | 1437.5 | 55.71 | 27.9 | Cellular motility driven by assembly and disassembly of actin filaments. | Thomas D Pollard, Gary G Borisy | Cell | 2003 | 12600310 | No |
1773 | 1437 | 1437.0 | 37.71 | 37.7 | Capacitative calcium entry revisited. | J W Putney | Cell Calcium | 1990 | 1965707 | No |
1774 | 1437 | 1437.0 | 0.0 | 0.0 | Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. | H E Huxley | J Mol Biol | 1963 | 14064165 | Yes |
1775 | 2874 | 1437.0 | 82.09 | 41.0 | Dali server: conservation mapping in 3D. | Liisa Holm, Päivi Rosenström | Nucleic Acids Res | 2010 | 20457744 | Yes |
1776 | 4310 | 1436.7 | 107.73 | 35.9 | Two-photon laser scanning fluorescence microscopy. | W Denk, J H Strickler, W W Webb | Science | 1990 | 2321027 | Yes |
1777 | 2873 | 1436.5 | 62.45 | 31.2 | The Ki-67 protein: from the known and the unknown. | T Scholzen, J Gerdes | J Cell Physiol | 2000 | 10653597 | No |
1778 | 1436 | 1436.0 | 30.36 | 30.4 | Regulatory T cells, tumour immunity and immunotherapy. | Weiping Zou | Nat Rev Immunol | 2006 | 16557261 | No |
1779 | 2871 | 1435.5 | 55.11 | 27.6 | Mutations affecting segment number and polarity in Drosophila. | C Nüsslein-Volhard, E Wieschaus | Nature | 1980 | 6776413 | Yes |
1780 | 1435 | 1435.0 | 0.0 | 0.0 | Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. | J W Olney | Science | 1969 | 5778021 | Yes |
1781 | 1435 | 1435.0 | 34.28 | 34.3 | Binary Agrobacterium vectors for plant transformation. | M Bevan | Nucleic Acids Res | 1984 | 6095209 | Yes |
1782 | 1435 | 1435.0 | 29.1 | 29.1 | Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. | D I Svergun | Biophys J | 1999 | 10354416 | Yes |
1783 | 2869 | 1434.5 | 60.44 | 30.2 | The Bcl2 family: regulators of the cellular life-or-death switch. | Suzanne Cory, Jerry M Adams | Nat Rev Cancer | 2002 | 12209154 | No |
1784 | 12909 | 1434.3 | 403.86 | 44.9 | The 1982 revised criteria for the classification of systemic lupus erythematosus. | E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J Winchester | Arthritis Rheum | 1982 | 7138600 | Yes |
1785 | 5734 | 1433.5 | 169.42 | 42.4 | Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. | B Biswal, F Z Yetkin, V M Haughton, J S Hyde | Magn Reson Med | 1995 | 8524021 | Yes |
1786 | 1433 | 1433.0 | 36.79 | 36.8 | The biology of incretin hormones. | Daniel J Drucker | Cell Metab | 2006 | 16517403 | No |
1787 | 1433 | 1433.0 | 52.88 | 52.9 | Falls in older people: epidemiology, risk factors and strategies for prevention. | Laurence Z Rubenstein | Age Ageing | 2006 | 16926202 | No |
1788 | 2865 | 1432.5 | 62.68 | 31.3 | Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. | E Krissinel, K Henrick | Acta Crystallogr D Biol Crystallogr | 2004 | 15572779 | Yes |
1789 | 1432 | 1432.0 | 46.33 | 46.3 | The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. | G R Buettner | Arch Biochem Biophys | 1993 | 8434935 | No |
1790 | 1431 | 1431.0 | 45.66 | 45.7 | Polycystic ovary syndrome. | S Franks | N Engl J Med | 1995 | 7651477 | No |
1791 | 1431 | 1431.0 | 37.21 | 37.2 | Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. | B Winkel-Shirley | Plant Physiol | 2001 | 11402179 | No |
1792 | 1431 | 1431.0 | 30.38 | 30.4 | Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. | R K Jain | Nat Med | 2001 | 11533692 | No |
1793 | 1431 | 1431.0 | 36.31 | 36.3 | Insulin and insulin-like growth factor signalling in neoplasia. | Michael Pollak | Nat Rev Cancer | 2008 | 19029956 | No |
1794 | 1430 | 1430.0 | 52.55 | 52.5 | The case-crossover design: a method for studying transient effects on the risk of acute events. | M Maclure | Am J Epidemiol | 1991 | 1985444 | Yes |
1795 | 1430 | 1430.0 | 25.84 | 25.8 | Histone acetylation and transcriptional regulatory mechanisms. | K Struhl | Genes Dev | 1998 | 9499396 | No |
1796 | 1430 | 1430.0 | 33.7 | 33.7 | Pathogenesis of group A streptococcal infections. | M W Cunningham | Clin Microbiol Rev | 2000 | 10885988 | No |
1797 | 1430 | 1430.0 | 34.89 | 34.9 | Neurovascular regulation in the normal brain and in Alzheimer's disease. | Costantino Iadecola | Nat Rev Neurosci | 2004 | 15100718 | No |
1798 | 1430 | 1430.0 | 50.56 | 50.6 | Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. | Joseph J Volpe | Lancet Neurol | 2009 | 19081519 | No |
1799 | 1430 | 1430.0 | 56.55 | 56.5 | Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. | Virginia A Moyer | Ann Intern Med | 2012 | 22801674 | No |
1800 | 1429 | 1429.0 | 59.75 | 59.8 | Responses to depression and their effects on the duration of depressive episodes. | S Nolen-Hoeksema | J Abnorm Psychol | 1991 | 1757671 | No |
1801 | 2857 | 1428.5 | 85.57 | 42.8 | An information-maximization approach to blind separation and blind deconvolution. | A J Bell, T J Sejnowski | Neural Comput | 1995 | 7584893 | Yes |
1802 | 1428 | 1428.0 | 36.56 | 36.6 | Lead- and drug-like compounds: the rule-of-five revolution. | Christopher A Lipinski | Drug Discov Today Technol | 2004 | 24981612 | Yes |
1803 | 5708 | 1427.0 | 246.85 | 61.7 | An inventory for measuring clinical anxiety: psychometric properties. | A T Beck, N Epstein, G Brown, R A Steer | J Consult Clin Psychol | 1988 | 3204199 | Yes |
1804 | 1426 | 1426.0 | 0.0 | 0.0 | A clinical method for assessing the ventilatory response to carbon dioxide. | D J Read | Australas Ann Med | 1967 | 6032026 | Yes |
1805 | 1426 | 1426.0 | 0.0 | 0.0 | A modified ninhydrin colorimetric analysis for amino acids. | H Rosen | Arch Biochem Biophys | 1957 | 13412116 | Yes |
1806 | 5700 | 1425.0 | 0.0 | 0.0 | A rating scale for mania: reliability, validity and sensitivity. | R C Young, J T Biggs, V E Ziegler, D A Meyer | Br J Psychiatry | 1978 | 728692 | Yes |
1807 | 4273 | 1424.3 | 0.0 | 0.0 | Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. | C A Winter, E A Risley, G W Nuss | Proc Soc Exp Biol Med | 1962 | 14001233 | Yes |
1808 | 1424 | 1424.0 | 33.69 | 33.7 | Developmental cell death: morphological diversity and multiple mechanisms. | P G Clarke | Anat Embryol (Berl) | 1990 | 2186664 | No |
1809 | 1424 | 1424.0 | 35.48 | 35.5 | General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. | R A Houghten | Proc Natl Acad Sci U S A | 1985 | 2410914 | Yes |
1810 | 1424 | 1424.0 | 84.53 | 84.5 | Deep learning in neural networks: an overview. | Jürgen Schmidhuber | Neural Netw | 2015 | 25462637 | No |
1811 | 1423 | 1423.0 | 0.0 | 0.0 | Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. | M P Blaustein | Am J Physiol | 1977 | 324293 | No |
1812 | 1423 | 1423.0 | 44.53 | 44.5 | Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. | L Bravo | Nutr Rev | 1998 | 9838798 | No |
1813 | 2844 | 1422.0 | 59.45 | 29.7 | Chemokines: a new classification system and their role in immunity. | A Zlotnik, O Yoshie | Immunity | 2000 | 10714678 | No |
1814 | 1421 | 1421.0 | 27.29 | 27.3 | Aggresomes, inclusion bodies and protein aggregation. | R R Kopito | Trends Cell Biol | 2000 | 11121744 | No |
1815 | 1419 | 1419.0 | 34.08 | 34.1 | PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. | B M Spiegelman | Diabetes | 1998 | 9568680 | No |
1816 | 1419 | 1419.0 | 0.0 | 0.0 | Modality and topographic properties of single neurons of cat's somatic sensory cortex. | V B Mountcastle | J Neurophysiol | 1957 | 13439410 | Yes |
1817 | 1419 | 1419.0 | 45.98 | 46.0 | Social relationships and health. | Sheldon Cohen | Am Psychol | 2004 | 15554821 | No |
1818 | 2836 | 1418.0 | 66.73 | 33.4 | A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. | L Buck, R Axel | Cell | 1991 | 1840504 | Yes |
1819 | 1418 | 1418.0 | 65.92 | 65.9 | The structure and properties of the sense of coherence scale. | A Antonovsky | Soc Sci Med | 1993 | 8480217 | Yes |
1820 | 2835 | 1417.5 | 87.8 | 43.9 | Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. | James J Gross, Oliver P John | J Pers Soc Psychol | 2003 | 12916575 | Yes |
1821 | 7080 | 1416.0 | 148.47 | 29.7 | Prospective identification of tumorigenic breast cancer cells. | Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F Clarke | Proc Natl Acad Sci U S A | 2003 | 12629218 | Yes |
1822 | 1416 | 1416.0 | 0.0 | 0.0 | The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. | O V Batson | Ann Surg | 1940 | 17857618 | Yes |
1823 | 2826 | 1413.0 | 0.0 | 0.0 | Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. | R L Heath, L Packer | Arch Biochem Biophys | 1968 | 5655425 | Yes |
1824 | 1413 | 1413.0 | 34.97 | 35.0 | The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. | H Maeda | Adv Enzyme Regul | 2001 | 11384745 | No |
1825 | 1413 | 1413.0 | 44.41 | 44.4 | Systemic lupus erythematosus. | George C Tsokos | N Engl J Med | 2011 | 22129255 | No |
1826 | 2822 | 1411.0 | 104.86 | 52.4 | Pain assessment: global use of the Brief Pain Inventory. | C S Cleeland, K M Ryan | Ann Acad Med Singap | 1994 | 8080219 | No |
1827 | 2822 | 1411.0 | 65.4 | 32.7 | How matrix metalloproteinases regulate cell behavior. | M D Sternlicht, Z Werb | Annu Rev Cell Dev Biol | 2001 | 11687497 | No |
1828 | 1411 | 1411.0 | 41.15 | 41.1 | Glycobiology: Toward Understanding the Function of Sugars. | Raymond A. Dwek | Chem Rev | 1996 | 11848770 | Yes |
1829 | 5642 | 1410.5 | 165.36 | 41.3 | Comorbidity measures for use with administrative data. | A Elixhauser, C Steiner, D R Harris, R M Coffey | Med Care | 1998 | 9431328 | Yes |
1830 | 2821 | 1410.5 | 101.71 | 50.9 | Neurocircuitry of addiction. | George F Koob, Nora D Volkow | Neuropsychopharmacology | 2010 | 19710631 | No |
1831 | 1409 | 1409.0 | 37.14 | 37.1 | Aspergillus fumigatus and aspergillosis. | J P Latgé | Clin Microbiol Rev | 1999 | 10194462 | No |
1832 | 1409 | 1409.0 | 38.31 | 38.3 | Integration, scaling, space-group assignment and post-refinement. | Wolfgang Kabsch | Acta Crystallogr D Biol Crystallogr | 2010 | 20124693 | Yes |
1833 | 2816 | 1408.0 | 66.71 | 33.4 | The MAPK signaling cascade. | R Seger, E G Krebs | FASEB J | 1995 | 7601337 | No |
1834 | 1408 | 1408.0 | 32.74 | 32.7 | The NCI60 human tumour cell line anticancer drug screen. | Robert H Shoemaker | Nat Rev Cancer | 2006 | 16990858 | No |
1835 | 2815 | 1407.5 | 77.41 | 38.7 | Early identification of refractory epilepsy. | P Kwan, M J Brodie | N Engl J Med | 2000 | 10660394 | Yes |
1836 | 4220 | 1406.7 | 146.56 | 48.9 | Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. | Aleksandr V Marenich, Christopher J Cramer, Donald G Truhlar | J Phys Chem B | 2009 | 19366259 | Yes |
1837 | 2813 | 1406.5 | 63.71 | 31.9 | Raster3D Version 2.0. A program for photorealistic molecular graphics. | E A Merritt, M E Murphy | Acta Crystallogr D Biol Crystallogr | 1994 | 15299354 | Yes |
1838 | 4219 | 1406.3 | 93.29 | 31.1 | NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. | S Ghosh, M J May, E B Kopp | Annu Rev Immunol | 1998 | 9597130 | No |
1839 | 1406 | 1406.0 | 43.89 | 43.9 | Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. | James J P Stewart | J Mol Model | 2007 | 17828561 | Yes |
1840 | 1405 | 1405.0 | 38.48 | 38.5 | External validity of randomised controlled trials: "to whom do the results of this trial apply?". | Peter M Rothwell | Lancet | 2005 | 15639683 | Yes |
1841 | 1404 | 1404.0 | 0.0 | 0.0 | The genetical evolution of social behaviour. II. | W D Hamilton | J Theor Biol | 1964 | 5875340 | Yes |
1842 | 2808 | 1404.0 | 0.0 | 0.0 | Microdetermination of long-chain fatty acids in plasma and tissues. | V P Dole, H Meinertz | J Biol Chem | 1960 | 13817286 | Yes |
1843 | 1404 | 1404.0 | 91.38 | 91.4 | The antibiotic resistance crisis: part 1: causes and threats. | C Lee Ventola | P T | 2015 | 25859123 | Yes |
1844 | 1403 | 1403.0 | 62.72 | 62.7 | KDIGO clinical practice guidelines for acute kidney injury. | Arif Khwaja | Nephron Clin Pract | 2012 | 22890468 | No |
1845 | 2805 | 1402.5 | 92.83 | 46.4 | Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. | G R Gibson, M B Roberfroid | J Nutr | 1995 | 7782892 | No |
1846 | 1402 | 1402.0 | 0.0 | 0.0 | R factor transfer in Rhizobium leguminosarum. | J E Beringer | J Gen Microbiol | 1974 | 4612098 | Yes |
1847 | 1402 | 1402.0 | 63.26 | 63.3 | Pro-resolving lipid mediators are leads for resolution physiology. | Charles N Serhan | Nature | 2014 | 24899309 | No |
1848 | 2803 | 1401.5 | 0.0 | 0.0 | The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. | E G Gray, V P Whittaker | J Anat | 1962 | 13901297 | Yes |
1849 | 2800 | 1400.0 | 0.0 | 0.0 | Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. | H J Bloom, W W Richardson | Br J Cancer | 1957 | 13499785 | Yes |
1850 | 1400 | 1400.0 | 41.05 | 41.0 | n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. | Philip C Calder | Am J Clin Nutr | 2006 | 16841861 | No |
1851 | 1399 | 1399.0 | 0.0 | 0.0 | Stability of proteins: small globular proteins. | P L Privalov | Adv Protein Chem | 1979 | 44431 | No |
1852 | 2798 | 1399.0 | 73.31 | 36.7 | Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. | I Issemann, S Green | Nature | 1990 | 2129546 | Yes |
1853 | 2798 | 1399.0 | 85.55 | 42.8 | The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. | J D Hayes, D J Pulford | Crit Rev Biochem Mol Biol | 1995 | 8770536 | No |
1854 | 2798 | 1399.0 | 71.23 | 35.6 | Steatohepatitis: a tale of two "hits"? | C P Day, O F James | Gastroenterology | 1998 | 9547102 | No |
1855 | 2798 | 1399.0 | 82.91 | 41.5 | EQ-5D: a measure of health status from the EuroQol Group. | R Rabin, F de Charro | Ann Med | 2001 | 11491192 | No |
1856 | 2798 | 1399.0 | 89.93 | 45.0 | Mechanisms of salinity tolerance. | Rana Munns, Mark Tester | Annu Rev Plant Biol | 2008 | 18444910 | No |
1857 | 2796 | 1398.0 | 64.12 | 32.1 | Microtubules as a target for anticancer drugs. | Mary Ann Jordan, Leslie Wilson | Nat Rev Cancer | 2004 | 15057285 | No |
1858 | 2794 | 1397.0 | 0.0 | 0.0 | A scaled version of the General Health Questionnaire. | D P Goldberg, V F Hillier | Psychol Med | 1979 | 424481 | Yes |
1859 | 4191 | 1397.0 | 121.48 | 40.5 | The fusiform face area: a module in human extrastriate cortex specialized for face perception. | N Kanwisher, J McDermott, M M Chun | J Neurosci | 1997 | 9151747 | Yes |
1860 | 1397 | 1397.0 | 58.78 | 58.8 | Adverse health effects of high-effort/low-reward conditions. | J Siegrist | J Occup Health Psychol | 1996 | 9547031 | No |
1861 | 1397 | 1397.0 | 27.38 | 27.4 | Vienna RNA secondary structure server. | Ivo L Hofacker | Nucleic Acids Res | 2003 | 12824340 | Yes |
1862 | 2794 | 1397.0 | 73.08 | 36.5 | Malignant gliomas in adults. | Patrick Y Wen, Santosh Kesari | N Engl J Med | 2008 | 18669428 | No |
1863 | 2794 | 1397.0 | 109.8 | 54.9 | Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. | Sarvajeet Singh Gill, Narendra Tuteja | Plant Physiol Biochem | 2010 | 20870416 | No |
1864 | 1396 | 1396.0 | 0.0 | 0.0 | Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. | J Wyman | Adv Protein Chem | 1964 | 14268785 | No |
1865 | 1396 | 1396.0 | 32.82 | 32.8 | The molecular logic of endocannabinoid signalling. | Daniele Piomelli | Nat Rev Neurosci | 2003 | 14595399 | No |
1866 | 2791 | 1395.5 | 0.0 | 0.0 | Empirical predictions of protein conformation. | P Y Chou, G D Fasman | Annu Rev Biochem | 1978 | 354496 | No |
1867 | 2791 | 1395.5 | 63.34 | 31.7 | Neurotrophins: roles in neuronal development and function. | E J Huang, L F Reichardt | Annu Rev Neurosci | 2001 | 11520916 | No |
1868 | 2791 | 1395.5 | 59.94 | 30.0 | Development by self-digestion: molecular mechanisms and biological functions of autophagy. | Beth Levine, Daniel J Klionsky | Dev Cell | 2004 | 15068787 | No |
1869 | 1394 | 1394.0 | 0.0 | 0.0 | Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. | C A Barnes | J Comp Physiol Psychol | 1979 | 221551 | Yes |
1870 | 1394 | 1394.0 | 32.18 | 32.2 | The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. | M Takeichi | Development | 1988 | 3048970 | No |
1871 | 1394 | 1394.0 | 0.0 | 0.0 | Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. | K S McCully | Am J Pathol | 1969 | 5792556 | Yes |
1872 | 1394 | 1394.0 | 33.11 | 33.1 | Far-field optical nanoscopy. | Stefan W Hell | Science | 2007 | 17525330 | No |
1873 | 1394 | 1394.0 | 43.81 | 43.8 | The many roles for fluorine in medicinal chemistry. | William K Hagmann | J Med Chem | 2008 | 18570365 | Yes |
1874 | 6968 | 1393.6 | 152.05 | 30.4 | Site-directed mutagenesis by overlap extension using the polymerase chain reaction. | S N Ho, H D Hunt, R M Horton, J K Pullen, L R Pease | Gene | 1989 | 2744487 | Yes |
1875 | 4180 | 1393.3 | 110.35 | 36.8 | Optimization by simulated annealing. | S Kirkpatrick, C D Gelatt, M P Vecchi | Science | 1983 | 17813860 | Yes |
1876 | 2786 | 1393.0 | 85.77 | 42.9 | Intracellular pH. | A Roos, W F Boron | Physiol Rev | 1981 | 7012859 | No |
1877 | 1392 | 1392.0 | 0.0 | 0.0 | Human cardiovascular adjustments to exercise and thermal stress. | L B Rowell | Physiol Rev | 1974 | 4587247 | No |
1878 | 1392 | 1392.0 | 0.0 | 0.0 | The measurement of psychological androgyny. | S L Bem | J Consult Clin Psychol | 1974 | 4823550 | Yes |
1879 | 1392 | 1392.0 | 33.2 | 33.2 | Functions of ceramide in coordinating cellular responses to stress. | Y A Hannun | Science | 1996 | 8943189 | No |
1880 | 2784 | 1392.0 | 68.09 | 34.0 | Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. | F Q Schafer, G R Buettner | Free Radic Biol Med | 2001 | 11368918 | No |
1881 | 2784 | 1392.0 | 90.56 | 45.3 | Density functionals with broad applicability in chemistry. | Yan Zhao, Donald G Truhlar | Acc Chem Res | 2008 | 18186612 | Yes |
1882 | 2784 | 1392.0 | 0.0 | 0.0 | Brain stem reticular formation and activation of the EEG. | G Moruzzi, H W Magoun | Electroencephalogr Clin Neurophysiol | 1949 | 18421835 | Yes |
1883 | 2782 | 1391.0 | 104.49 | 52.2 | The need to belong: desire for interpersonal attachments as a fundamental human motivation. | R F Baumeister, M R Leary | Psychol Bull | 1995 | 7777651 | No |
1884 | 2781 | 1390.5 | 82.42 | 41.2 | Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. | Sally S Dickerson, Margaret E Kemeny | Psychol Bull | 2004 | 15122924 | Yes |
1885 | 1390 | 1390.0 | 0.0 | 0.0 | Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. | W C Schneider | J Biol Chem | 1948 | 18886166 | Yes |
1886 | 2779 | 1389.5 | 58.73 | 29.4 | Fitting a mixture model by expectation maximization to discover motifs in biopolymers. | T L Bailey, C Elkan | Proc Int Conf Intell Syst Mol Biol | 1994 | 7584402 | Yes |
1887 | 2779 | 1389.5 | 60.2 | 30.1 | Coordination of circadian timing in mammals. | Steven M Reppert, David R Weaver | Nature | 2002 | 12198538 | No |
1888 | 4168 | 1389.3 | 135.45 | 45.1 | Estimating the mean and variance from the median, range, and the size of a sample. | Stela Pudar Hozo, Benjamin Djulbegovic, Iztok Hozo | BMC Med Res Methodol | 2005 | 15840177 | Yes |
1889 | 2776 | 1388.0 | 89.11 | 44.6 | Functional architecture of basal ganglia circuits: neural substrates of parallel processing. | G E Alexander, M D Crutcher | Trends Neurosci | 1990 | 1695401 | No |
1890 | 1388 | 1388.0 | 72.6 | 72.6 | Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. | F E Zajac | Crit Rev Biomed Eng | 1989 | 2676342 | No |
1891 | 1388 | 1388.0 | 32.79 | 32.8 | Speculations on the functions of the major heat shock and glucose-regulated proteins. | H R Pelham | Cell | 1986 | 2944601 | Yes |
1892 | 2775 | 1387.5 | 0.0 | 0.0 | A method of trace iodination of proteins for immunologic studies. | P J McConahey, F J Dixon | Int Arch Allergy Appl Immunol | 1966 | 4160044 | Yes |
1893 | 1387 | 1387.0 | 40.3 | 40.3 | Isolation and cultivation of Lyme disease spirochetes. | A G Barbour | Yale J Biol Med | 1984 | 6393604 | Yes |
1894 | 1387 | 1387.0 | 31.07 | 31.1 | Protein misfolding, evolution and disease. | C M Dobson | Trends Biochem Sci | 1999 | 10470028 | No |
1895 | 1387 | 1387.0 | 42.36 | 42.4 | Semiempirical hybrid density functional with perturbative second-order correlation. | Stefan Grimme | J Chem Phys | 2006 | 16438568 | Yes |
1896 | 5547 | 1386.8 | 126.24 | 31.6 | Probability-based protein identification by searching sequence databases using mass spectrometry data. | D N Perkins, D J Pappin, D M Creasy, J S Cottrell | Electrophoresis | 1999 | 10612281 | Yes |
1897 | 5547 | 1386.8 | 168.44 | 42.1 | The validity of the Hospital Anxiety and Depression Scale. An updated literature review. | Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag Neckelmann | J Psychosom Res | 2002 | 11832252 | No |
1898 | 4160 | 1386.7 | 123.26 | 41.1 | Regularization Paths for Generalized Linear Models via Coordinate Descent. | Jerome Friedman, Trevor Hastie, Rob Tibshirani | J Stat Softw | 2010 | 20808728 | Yes |
1899 | 4159 | 1386.3 | 142.23 | 47.4 | Vascular endothelial cells synthesize nitric oxide from L-arginine. | R M Palmer, D S Ashton, S Moncada | Nature | 1988 | 3131684 | Yes |
1900 | 2771 | 1385.5 | 92.37 | 46.2 | The efficiency of systematic sampling in stereology and its prediction. | H J Gundersen, E B Jensen | J Microsc | 1987 | 3430576 | Yes |
1901 | 2771 | 1385.5 | 72.04 | 36.0 | A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. | J Messing, J Vieira | Gene | 1982 | 6295880 | Yes |
1902 | 2770 | 1385.0 | 62.38 | 31.2 | An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. | A A Beg, D Baltimore | Science | 1996 | 8864118 | Yes |
1903 | 2769 | 1384.5 | 0.0 | 0.0 | The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. | J O'Keefe, J Dostrovsky | Brain Res | 1971 | 5124915 | Yes |
1904 | 1384 | 1384.0 | 0.0 | 0.0 | Selection of successive tumour lines for metastasis. | I J Fidler | Nat New Biol | 1973 | 4512654 | Yes |
1905 | 2768 | 1384.0 | 111.51 | 55.8 | Assessment of eating disorders: interview or self-report questionnaire? | C G Fairburn, S J Beglin | Int J Eat Disord | 1994 | 7866415 | Yes |
1906 | 2767 | 1383.5 | 0.0 | 0.0 | Mutations of Bacteria from Virus Sensitivity to Virus Resistance. | S E Luria, M Delbrück | Genetics | 1943 | 17247100 | Yes |
1907 | 1383 | 1383.0 | 0.0 | 0.0 | Note on the sampling error of the difference between correlated proportions or percentages. | Q McNEMAR | Psychometrika | 1947 | 20254758 | Yes |
1908 | 2765 | 1382.5 | 0.0 | 0.0 | A protein sequenator. | P Edman, G Begg | Eur J Biochem | 1967 | 6059350 | Yes |
1909 | 1382 | 1382.0 | 0.0 | 0.0 | Microbial ecology of the gastrointestinal tract. | D C Savage | Annu Rev Microbiol | 1977 | 334036 | No |
1910 | 1382 | 1382.0 | 26.55 | 26.6 | Ubiquitin-dependent protein degradation. | M Hochstrasser | Annu Rev Genet | 1996 | 8982460 | No |
1911 | 1382 | 1382.0 | 38.15 | 38.1 | Task switching. | Stephen Monsell | Trends Cogn Sci | 2003 | 12639695 | Yes |
1912 | 1382 | 1382.0 | 28.96 | 29.0 | RNA silencing in plants. | David Baulcombe | Nature | 2004 | 15372043 | No |
1913 | 1382 | 1382.0 | 34.81 | 34.8 | Five rules for the evolution of cooperation. | Martin A Nowak | Science | 2006 | 17158317 | No |
1914 | 8289 | 1381.5 | 280.5 | 46.8 | New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. | Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier Gascuel | Syst Biol | 2010 | 20525638 | Yes |
1915 | 1381 | 1381.0 | 56.98 | 57.0 | A structured interview guide for the Hamilton Depression Rating Scale. | J B Williams | Arch Gen Psychiatry | 1988 | 3395203 | Yes |
1916 | 1381 | 1381.0 | 31.85 | 31.9 | Tumor metastasis: mechanistic insights and clinical challenges. | Patricia S Steeg | Nat Med | 2006 | 16892035 | No |
1917 | 1381 | 1381.0 | 42.95 | 43.0 | Surface plasmon resonance sensors for detection of chemical and biological species. | Jirí Homola | Chem Rev | 2008 | 18229953 | No |
1918 | 2761 | 1380.5 | 70.79 | 35.4 | CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. | D G Higgins, P M Sharp | Gene | 1988 | 3243435 | Yes |
1919 | 1380 | 1380.0 | 45.12 | 45.1 | Efficient analysis of experimental observations. | W J Dixon | Annu Rev Pharmacol Toxicol | 1980 | 7387124 | Yes |
1920 | 1380 | 1380.0 | 40.12 | 40.1 | Leishmaniasis: current situation and new perspectives. | P Desjeux | Comp Immunol Microbiol Infect Dis | 2004 | 15225981 | No |
1921 | 1380 | 1380.0 | 35.17 | 35.2 | Myeloperoxidase: friend and foe. | Seymour J Klebanoff | J Leukoc Biol | 2005 | 15689384 | No |
1922 | 1378 | 1378.0 | 91.97 | 92.0 | The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. | F C Ewald | Clin Orthop Relat Res | 1989 | 2805502 | Yes |
1923 | 1378 | 1378.0 | 30.18 | 30.2 | Neurotrophins as synaptic modulators. | M M Poo | Nat Rev Neurosci | 2001 | 11253356 | No |
1924 | 2753 | 1376.5 | 0.0 | 0.0 | Prediction of protein conformation. | P Y Chou, G D Fasman | Biochemistry | 1974 | 4358940 | Yes |
1925 | 2753 | 1376.5 | 98.96 | 49.5 | The Oswestry Disability Index. | J C Fairbank, P B Pynsent | Spine (Phila Pa 1976) | 2000 | 11074683 | No |
1926 | 1375 | 1375.0 | 31.47 | 31.5 | Cancer epigenomics: DNA methylomes and histone-modification maps. | Manel Esteller | Nat Rev Genet | 2007 | 17339880 | No |
1927 | 1375 | 1375.0 | 35.5 | 35.5 | The failing heart--an engine out of fuel. | Stefan Neubauer | N Engl J Med | 2007 | 17360992 | No |
1928 | 2748 | 1374.0 | 168.45 | 84.2 | Rating systems in the evaluation of knee ligament injuries. | Y Tegner, J Lysholm | Clin Orthop Relat Res | 1985 | 4028566 | Yes |
1929 | 1374 | 1374.0 | 31.95 | 31.9 | Protein kinase C: structure, function, and regulation. | A C Newton | J Biol Chem | 1995 | 7499357 | No |
1930 | 2748 | 1374.0 | 84.67 | 42.3 | Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. | P J Basser, C Pierpaoli | J Magn Reson B | 1996 | 8661285 | Yes |
1931 | 2747 | 1373.5 | 64.28 | 32.1 | Lipopolysaccharide endotoxins. | Christian R H Raetz, Chris Whitfield | Annu Rev Biochem | 2002 | 12045108 | No |
1932 | 1373 | 1373.0 | 29.29 | 29.3 | Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. | S S Ferguson | Pharmacol Rev | 2001 | 11171937 | No |
1933 | 1373 | 1373.0 | 0.0 | 0.0 | An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. | O Smithies | Biochem J | 1959 | 13638269 | Yes |
1934 | 1372 | 1372.0 | 0.0 | 0.0 | Codon--anticodon pairing: the wobble hypothesis. | F H Crick | J Mol Biol | 1966 | 5969078 | Yes |
1935 | 1372 | 1372.0 | 26.47 | 26.5 | NK cell receptors. | L L Lanier | Annu Rev Immunol | 1998 | 9597134 | No |
1936 | 1372 | 1372.0 | 35.27 | 35.3 | An economic method for the fluorescent labeling of PCR fragments. | M Schuelke | Nat Biotechnol | 2000 | 10657137 | Yes |
1937 | 1372 | 1372.0 | 38.89 | 38.9 | A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. | J Engel | Epilepsia | 2001 | 11422340 | Yes |
1938 | 1372 | 1372.0 | 32.3 | 32.3 | Ordered porous materials for emerging applications. | Mark E Davis | Nature | 2002 | 12075343 | No |
1939 | 1372 | 1372.0 | 0.0 | 0.0 | Effects of varying the vehicle for OsO4 in tissue fixation. | J B Caulfield | J Biophys Biochem Cytol | 1957 | 13475399 | Yes |
1940 | 1372 | 1372.0 | 0.0 | 0.0 | Potential, Impedance, And Rectification In Membranes. | D E Goldman | J Gen Physiol | 1943 | 19873371 | Yes |
1941 | 4115 | 1371.7 | 143.82 | 47.9 | Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. | Helga Thorvaldsdóttir, James T Robinson, Jill P Mesirov | Brief Bioinform | 2013 | 22517427 | Yes |
1942 | 9599 | 1371.3 | 213.78 | 30.5 | Embryonic stem cell lines derived from human blastocysts. | J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M Jones | Science | 1998 | 9804556 | Yes |
1943 | 2742 | 1371.0 | 63.22 | 31.6 | Cancer metastasis: building a framework. | Gaorav P Gupta, Joan Massagué | Cell | 2006 | 17110329 | No |
1944 | 2742 | 1371.0 | 0.0 | 0.0 | The effect of sodium ions on the electrical activity of giant axon of the squid. | A L Hodgkin, B Katz | J Physiol | 1949 | 18128147 | Yes |
1945 | 2740 | 1370.0 | 0.0 | 0.0 | Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. | A J Berk, P A Sharp | Cell | 1977 | 922889 | Yes |
1946 | 1370 | 1370.0 | 37.13 | 37.1 | Cell and environment interactions in tumor microregions: the multicell spheroid model. | R M Sutherland | Science | 1988 | 2451290 | Yes |
1947 | 1370 | 1370.0 | 33.29 | 33.3 | The basic science of gene therapy. | R C Mulligan | Science | 1993 | 8493530 | No |
1948 | 1370 | 1370.0 | 35.38 | 35.4 | Stress and hippocampal plasticity. | B S McEwen | Annu Rev Neurosci | 1999 | 10202533 | No |
1949 | 2739 | 1369.5 | 121.39 | 60.7 | Deciphering key features in protein structures with the new ENDscript server. | Xavier Robert, Patrice Gouet | Nucleic Acids Res | 2014 | 24753421 | Yes |
1950 | 4108 | 1369.3 | 177.35 | 59.1 | Molecular mechanisms of epithelial-mesenchymal transition. | Samy Lamouille, Jian Xu, Rik Derynck | Nat Rev Mol Cell Biol | 2014 | 24556840 | No |
1951 | 1369 | 1369.0 | 33.29 | 33.3 | Two pathogenetic types of endometrial carcinoma. | J V Bokhman | Gynecol Oncol | 1983 | 6822361 | Yes |
1952 | 2737 | 1368.5 | 115.0 | 57.5 | Regulation of microRNA biogenesis. | Minju Ha, V Narry Kim | Nat Rev Mol Cell Biol | 2014 | 25027649 | No |
1953 | 2736 | 1368.0 | 53.37 | 26.7 | T-cell antigen receptor genes and T-cell recognition. | M M Davis, P J Bjorkman | Nature | 1988 | 3043226 | No |
1954 | 1368 | 1368.0 | 0.0 | 0.0 | Cerebral vascular accidents in patients over the age of 60. II. Prognosis. | J Rankin | Scott Med J | 1957 | 13432835 | Yes |
1955 | 2735 | 1367.5 | 70.86 | 35.4 | Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. | D Marion, K Wüthrich | Biochem Biophys Res Commun | 1983 | 6307308 | Yes |
1956 | 2735 | 1367.5 | 77.56 | 38.8 | Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. | B R Celli, W MacNee | Eur Respir J | 2004 | 15219010 | No |
1957 | 2735 | 1367.5 | 73.12 | 36.6 | Obesity. | David W Haslam, W Philip T James | Lancet | 2005 | 16198769 | No |
1958 | 1367 | 1367.0 | 0.0 | 0.0 | Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. | S S Lehrer | Biochemistry | 1971 | 5119250 | Yes |
1959 | 2734 | 1367.0 | 113.93 | 57.0 | Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. | A Y Finlay, G K Khan | Clin Exp Dermatol | 1994 | 8033378 | Yes |
1960 | 2734 | 1367.0 | 54.75 | 27.4 | The evolutionary fate and consequences of duplicate genes. | M Lynch, J S Conery | Science | 2000 | 11073452 | No |
1961 | 1367 | 1367.0 | 51.82 | 51.8 | Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. | Peter C Austin | Pharm Stat | 2011 | 20925139 | Yes |
1962 | 2733 | 1366.5 | 76.46 | 38.2 | Transforming growth factor beta in tissue fibrosis. | W A Border, N A Noble | N Engl J Med | 1994 | 7935686 | No |
1963 | 2732 | 1366.0 | 82.44 | 41.2 | Glycine potentiates the NMDA response in cultured mouse brain neurons. | J W Johnson, P Ascher | Nature | 1987 | 2433595 | Yes |
1964 | 4098 | 1366.0 | 88.83 | 29.6 | Toll-like receptors. | Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira | Annu Rev Immunol | 2003 | 12524386 | No |
1965 | 2732 | 1366.0 | 0.0 | 0.0 | Immunoassay of endogenous plasma insulin in man. | R S Yalow, S A Berson | J Clin Invest | 1960 | 13846364 | Yes |
1966 | 1365 | 1365.0 | 37.18 | 37.2 | A more meaningful scoring system for determining the severity of coronary heart disease. | G G Gensini | Am J Cardiol | 1983 | 6823874 | Yes |
1967 | 1365 | 1365.0 | 33.63 | 33.6 | Neuronal synchrony: a versatile code for the definition of relations? | W Singer | Neuron | 1999 | 10677026 | No |
1968 | 1365 | 1365.0 | 31.88 | 31.9 | Hematopoietic stem-cell transplantation. | Edward A Copelan | N Engl J Med | 2006 | 16641398 | No |
1969 | 1365 | 1365.0 | 36.51 | 36.5 | Use and misuse of the receiver operating characteristic curve in risk prediction. | Nancy R Cook | Circulation | 2007 | 17309939 | Yes |
1970 | 2729 | 1364.5 | 99.3 | 49.6 | Saliency, switching, attention and control: a network model of insula function. | Vinod Menon, Lucina Q Uddin | Brain Struct Funct | 2010 | 20512370 | No |
1971 | 1364 | 1364.0 | 34.43 | 34.4 | The use of nanocrystals in biological detection. | Paul Alivisatos | Nat Biotechnol | 2004 | 14704706 | Yes |
1972 | 4091 | 1363.7 | 97.42 | 32.5 | Click Chemistry: Diverse Chemical Function from a Few Good Reactions. | Hartmuth C. Kolb, M. G. Finn, K. Barry Sharpless | Angew Chem Int Ed Engl | 2001 | 11433435 | Yes |
1973 | 4091 | 1363.7 | 102.58 | 34.2 | Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. | Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck Ørntoft | Cancer Res | 2004 | 15289330 | Yes |
1974 | 2727 | 1363.5 | 99.91 | 50.0 | Biology of disease: free radicals and tissue injury. | B A Freeman, J D Crapo | Lab Invest | 1982 | 6290784 | No |
1975 | 1363 | 1363.0 | 54.41 | 54.4 | Cardiac valve surgery--the "French correction". | A Carpentier | J Thorac Cardiovasc Surg | 1983 | 6887954 | Yes |
1976 | 1363 | 1363.0 | 48.22 | 48.2 | The polyvagal perspective. | Stephen W Porges | Biol Psychol | 2007 | 17049418 | No |
1977 | 2725 | 1362.5 | 63.13 | 31.6 | NF-kappaB: a key role in inflammatory diseases. | P P Tak, G S Firestein | J Clin Invest | 2001 | 11134171 | No |
1978 | 1362 | 1362.0 | 30.6 | 30.6 | Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. | M Kozak | Microbiol Rev | 1983 | 6343825 | No |
1979 | 1362 | 1362.0 | 26.33 | 26.3 | Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. | M G Gustafsson | J Microsc | 2000 | 10810003 | Yes |
1980 | 1362 | 1362.0 | 66.68 | 66.7 | What's in a name? Qualitative description revisited. | Margarete Sandelowski | Res Nurs Health | 2010 | 20014004 | Yes |
1981 | 4085 | 1361.7 | 91.02 | 30.3 | Telomeres shorten during ageing of human fibroblasts. | C B Harley, A B Futcher, C W Greider | Nature | 1990 | 2342578 | Yes |
1982 | 1361 | 1361.0 | 47.92 | 47.9 | Multiple calcium channels and neuronal function. | R J Miller | Science | 1987 | 2432656 | No |
1983 | 2722 | 1361.0 | 89.45 | 44.7 | Unidentified curved bacilli on gastric epithelium in active chronic gastritis. | J R Warren, B Marshall | Lancet | 1983 | 6134060 | Yes |
1984 | 1360 | 1360.0 | 40.49 | 40.5 | The aging process. | D Harman | Proc Natl Acad Sci U S A | 1981 | 6947277 | Yes |
1985 | 2719 | 1359.5 | 86.38 | 43.2 | Performing the exact test of Hardy-Weinberg proportion for multiple alleles. | S W Guo, E A Thompson | Biometrics | 1992 | 1637966 | Yes |
1986 | 1359 | 1359.0 | 0.0 | 0.0 | Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. | T Spector | Anal Biochem | 1978 | 655375 | Yes |
1987 | 1359 | 1359.0 | 43.72 | 43.7 | Equipoise and the ethics of clinical research. | B Freedman | N Engl J Med | 1987 | 3600702 | Yes |
1988 | 4071 | 1357.0 | 91.69 | 30.6 | TOR signaling in growth and metabolism. | Stephan Wullschleger, Robbie Loewith, Michael N Hall | Cell | 2006 | 16469695 | No |
1989 | 4070 | 1356.7 | 0.0 | 0.0 | Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. | J Garnier, D J Osguthorpe, B Robson | J Mol Biol | 1978 | 642007 | Yes |
1990 | 1356 | 1356.0 | 27.95 | 27.9 | Macromolecular crowding: obvious but underappreciated. | R J Ellis | Trends Biochem Sci | 2001 | 11590012 | No |
1991 | 1356 | 1356.0 | 29.17 | 29.2 | The Buccaneer software for automated model building. 1. Tracing protein chains. | Kevin Cowtan | Acta Crystallogr D Biol Crystallogr | 2006 | 16929101 | Yes |
1992 | 1355 | 1355.0 | 45.52 | 45.5 | Interleukin-1. | C A Dinarello | Rev Infect Dis | 1984 | 6369481 | No |
1993 | 2710 | 1355.0 | 66.52 | 33.3 | Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. | H Cai, D G Harrison | Circ Res | 2000 | 11073878 | No |
1994 | 2709 | 1354.5 | 67.89 | 33.9 | Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. | E S Lander, D Botstein | Genetics | 1989 | 2563713 | Yes |
1995 | 1353 | 1353.0 | 36.19 | 36.2 | Hydrogels for biomedical applications. | Allan S Hoffman | Adv Drug Deliv Rev | 2002 | 11755703 | No |
1996 | 1352 | 1352.0 | 41.9 | 41.9 | Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). | Gunther Eysenbach | J Med Internet Res | 2004 | 15471760 | No |
1997 | 1351 | 1351.0 | 0.0 | 0.0 | Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. | J R David | Proc Natl Acad Sci U S A | 1966 | 5229858 | Yes |
1998 | 1351 | 1351.0 | 33.36 | 33.4 | Oxidative stress in Parkinson's disease. | Peter Jenner | Ann Neurol | 2003 | 12666096 | No |
1999 | 1350 | 1350.0 | 48.88 | 48.9 | Colorimetric determination of phospholipids with ammonium ferrothiocyanate. | J C Stewart | Anal Biochem | 1980 | 6892980 | Yes |
2000 | 2700 | 1350.0 | 73.75 | 36.9 | Macrophage diversity enhances tumor progression and metastasis. | Bin-Zhi Qian, Jeffrey W Pollard | Cell | 2010 | 20371344 | No |
2001 | 4047 | 1349.0 | 0.0 | 0.0 | Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. | D D Sabatini, K Bensch, R J Barrnett | J Cell Biol | 1963 | 13975866 | Yes |
2002 | 2695 | 1347.5 | 0.0 | 0.0 | Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. | A Dahlstroem, K Fuxe | Acta Physiol Scand Suppl | 1964 | 14229500 | Yes |
2003 | 2693 | 1346.5 | 69.33 | 34.7 | Unravelling the pathogenesis of inflammatory bowel disease. | R J Xavier, D K Podolsky | Nature | 2007 | 17653185 | No |
2004 | 2691 | 1345.5 | 0.0 | 0.0 | Peptidoglycan types of bacterial cell walls and their taxonomic implications. | K H Schleifer, O Kandler | Bacteriol Rev | 1972 | 4568761 | No |
2005 | 2691 | 1345.5 | 83.82 | 41.9 | From best evidence to best practice: effective implementation of change in patients' care. | Richard Grol, Jeremy Grimshaw | Lancet | 2003 | 14568747 | No |
2006 | 1345 | 1345.0 | 44.85 | 44.9 | Stress signalling pathways that impair prefrontal cortex structure and function. | Amy F T Arnsten | Nat Rev Neurosci | 2009 | 19455173 | No |
2007 | 1344 | 1344.0 | 0.0 | 0.0 | A modified procedure for lead staining of thin sections. | G Millonig | J Biophys Biochem Cytol | 1961 | 14474176 | Yes |
2008 | 2686 | 1343.0 | 0.0 | 0.0 | Selective loss of central cholinergic neurons in Alzheimer's disease. | P Davies, A J Maloney | Lancet | 1976 | 63862 | Yes |
2009 | 2686 | 1343.0 | 0.0 | 0.0 | Synchronization of Plasmodium falciparum erythrocytic stages in culture. | C Lambros, J P Vanderberg | J Parasitol | 1979 | 383936 | Yes |
2010 | 1343 | 1343.0 | 25.28 | 25.3 | The DNA methyltransferases of mammals. | T H Bestor | Hum Mol Genet | 2000 | 11005794 | No |
2011 | 5372 | 1343.0 | 232.47 | 58.1 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | Int J Surg | 2010 | 20171303 | No |
2012 | 6714 | 1342.8 | 295.19 | 59.0 | UCHIME improves sensitivity and speed of chimera detection. | Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob Knight | Bioinformatics | 2011 | 21700674 | Yes |
2013 | 2685 | 1342.5 | 77.48 | 38.7 | Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. | F D Lublin, S C Reingold | Neurology | 1996 | 8780061 | Yes |
2014 | 1342 | 1342.0 | 0.0 | 0.0 | Blood gas calculator. | J W Severinghaus | J Appl Physiol | 1966 | 5912737 | Yes |
2015 | 1341 | 1341.0 | 45.54 | 45.5 | Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. | N Krieger | Am J Public Health | 1992 | 1566949 | Yes |
2016 | 1341 | 1341.0 | 32.57 | 32.6 | Neurotrophin-regulated signalling pathways. | Louis F Reichardt | Philos Trans R Soc Lond B Biol Sci | 2006 | 16939974 | No |
2017 | 2680 | 1340.0 | 0.0 | 0.0 | Further improvements in the plaque technique for detecting single antibody-forming cells. | A J Cunningham, A Szenberg | Immunology | 1968 | 5653817 | Yes |
2018 | 2680 | 1340.0 | 60.99 | 30.5 | Self-assembly at all scales. | George M Whitesides, Bartosz Grzybowski | Science | 2002 | 11923529 | Yes |
2019 | 2679 | 1339.5 | 67.83 | 33.9 | Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. | M D Pierschbacher, E Ruoslahti | Nature | 1984 | 6325925 | Yes |
2020 | 2679 | 1339.5 | 0.0 | 0.0 | The respiratory chain and oxidative phosphorylation. | B Chance, G R Williams | Adv Enzymol Relat Subj Biochem | 1956 | 13313307 | Yes |
2021 | 5357 | 1339.2 | 0.0 | 0.0 | Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. | D W Cleveland, S G Fischer, M W Kirschner, U K Laemmli | J Biol Chem | 1977 | 320200 | Yes |
2022 | 1339 | 1339.0 | 36.72 | 36.7 | The world health report 2002 - reducing risks, promoting healthy life. | J J Guilbert | Educ Health (Abingdon) | 2003 | 14741909 | Yes |
2023 | 2677 | 1338.5 | 77.81 | 38.9 | Mortality by cause for eight regions of the world: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9142060 | Yes |
2024 | 1338 | 1338.0 | 32.89 | 32.9 | Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. | G von Heijne | J Mol Biol | 1992 | 1593632 | Yes |
2025 | 2676 | 1338.0 | 63.08 | 31.5 | NF-kappa B: ten years after. | P A Baeuerle, D Baltimore | Cell | 1996 | 8858144 | No |
2026 | 1338 | 1338.0 | 0.0 | 0.0 | Immunological function of the thymus. | J F Miller | Lancet | 1961 | 14474038 | Yes |
2027 | 1337 | 1337.0 | 0.0 | 0.0 | Stereological principles for morphometry in electron microscopic cytology. | E R Weibel | Int Rev Cytol | 1969 | 4899604 | No |
2028 | 2673 | 1336.5 | 0.0 | 0.0 | Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. | G J Miller, N E Miller | Lancet | 1975 | 46338 | Yes |
2029 | 1336 | 1336.0 | 34.78 | 34.8 | The amygdala modulates the consolidation of memories of emotionally arousing experiences. | James L McGaugh | Annu Rev Neurosci | 2004 | 15217324 | No |
2030 | 2671 | 1335.5 | 0.0 | 0.0 | Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. | E Engvall, P Perlmann | J Immunol | 1972 | 4113792 | Yes |
2031 | 1335 | 1335.0 | 0.0 | 0.0 | Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. | K Fuxe | Acta Physiol Scand Suppl | 1965 | 14319769 | Yes |
2032 | 17350 | 1334.6 | 485.84 | 37.4 | Clustal W and Clustal X version 2.0. | M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G Higgins | Bioinformatics | 2007 | 17846036 | Yes |
2033 | 2667 | 1333.5 | 55.39 | 27.7 | Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. | P J Southern, P Berg | J Mol Appl Genet | 1982 | 6286831 | Yes |
2034 | 2666 | 1333.0 | 68.82 | 34.4 | Molecular beacons: probes that fluoresce upon hybridization. | S Tyagi, F R Kramer | Nat Biotechnol | 1996 | 9630890 | Yes |
2035 | 2666 | 1333.0 | 56.46 | 28.2 | Intrinsically unstructured proteins and their functions. | H Jane Dyson, Peter E Wright | Nat Rev Mol Cell Biol | 2005 | 15738986 | No |
2036 | 5331 | 1332.8 | 143.27 | 35.8 | Most mammalian mRNAs are conserved targets of microRNAs. | Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel | Genome Res | 2009 | 18955434 | Yes |
2037 | 2665 | 1332.5 | 0.0 | 0.0 | Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. | E Engvall, P Perlmann | Immunochemistry | 1971 | 5135623 | Yes |
2038 | 1332 | 1332.0 | 41.52 | 41.5 | Neurotransmitters and neuromodulators in the basal ganglia. | A M Graybiel | Trends Neurosci | 1990 | 1695398 | No |
2039 | 1332 | 1332.0 | 43.05 | 43.0 | Glutathione metabolism and its selective modification. | A Meister | J Biol Chem | 1988 | 3053703 | No |
2040 | 1331 | 1331.0 | 48.27 | 48.3 | Matching methods for causal inference: A review and a look forward. | Elizabeth A Stuart | Stat Sci | 2010 | 20871802 | Yes |
2041 | 1330 | 1330.0 | 30.98 | 31.0 | The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. | S E Kahn | Diabetologia | 2003 | 12637977 | No |
2042 | 2660 | 1330.0 | 54.52 | 27.3 | Cancer genes and the pathways they control. | Bert Vogelstein, Kenneth W Kinzler | Nat Med | 2004 | 15286780 | No |
2043 | 2656 | 1328.0 | 95.18 | 47.6 | A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. | C M Tsai, C E Frasch | Anal Biochem | 1982 | 6176137 | Yes |
2044 | 2656 | 1328.0 | 0.0 | 0.0 | Virus interference. I. The interferon. | A Isaacs, J Lindenmann | Proc R Soc Lond B Biol Sci | 1957 | 13465720 | Yes |
2045 | 1327 | 1327.0 | 0.0 | 0.0 | Renin-angiotensin system: biochemistry and mechanisms of action. | M J Peach | Physiol Rev | 1977 | 191856 | No |
2046 | 1327 | 1327.0 | 65.06 | 65.1 | Molecular pathology of schizophrenia: more than one disease process? | T J Crow | Br Med J | 1980 | 6101544 | No |
2047 | 1327 | 1327.0 | 55.39 | 55.4 | Sample size in qualitative research. | M Sandelowski | Res Nurs Health | 1995 | 7899572 | Yes |
2048 | 1327 | 1327.0 | 48.15 | 48.1 | The global impact of pre-eclampsia and eclampsia. | Lelia Duley | Semin Perinatol | 2009 | 19464502 | No |
2049 | 2652 | 1326.0 | 51.58 | 25.8 | Oncogenic kinase signalling. | P Blume-Jensen, T Hunter | Nature | 2001 | 11357143 | No |
2050 | 2650 | 1325.0 | 0.0 | 0.0 | Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. | G Blobel, B Dobberstein | J Cell Biol | 1975 | 811671 | Yes |
2051 | 1325 | 1325.0 | 0.0 | 0.0 | Origin of concatemeric T7 DNA. | J D Watson | Nat New Biol | 1972 | 4507727 | Yes |
2052 | 1325 | 1325.0 | 35.91 | 35.9 | Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. | S L Friedman | N Engl J Med | 1993 | 8502273 | No |
2053 | 2648 | 1324.0 | 0.0 | 0.0 | Immunization of dissociated spleen cell cultures from normal mice. | R I Mishell, R W Dutton | J Exp Med | 1967 | 6034749 | Yes |
2054 | 1324 | 1324.0 | 31.07 | 31.1 | Hyaluronan: from extracellular glue to pericellular cue. | Bryan P Toole | Nat Rev Cancer | 2004 | 15229478 | No |
2055 | 1324 | 1324.0 | 0.0 | 0.0 | Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. | P F Scholander | J Biol Chem | 1947 | 20281644 | Yes |
2056 | 5296 | 1324.0 | 299.57 | 74.9 | Prevalence of childhood and adult obesity in the United States, 2011-2012. | Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M Flegal | JAMA | 2014 | 24570244 | Yes |
2057 | 2647 | 1323.5 | 83.06 | 41.5 | Protective and pathogenic functions of macrophage subsets. | Peter J Murray, Thomas A Wynn | Nat Rev Immunol | 2011 | 21997792 | No |
2058 | 1323 | 1323.0 | 0.0 | 0.0 | The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. | R C Lewontin | Genetics | 1964 | 17248194 | Yes |
2059 | 1322 | 1322.0 | 41.29 | 41.3 | Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. | M Robin DiMatteo | Med Care | 2004 | 15076819 | Yes |
2060 | 1321 | 1321.0 | 47.81 | 47.8 | Neuropeptide Y: complete amino acid sequence of the brain peptide. | K Tatemoto | Proc Natl Acad Sci U S A | 1982 | 6957876 | Yes |
2061 | 1321 | 1321.0 | 27.22 | 27.2 | Dimerization of cell surface receptors in signal transduction. | C H Heldin | Cell | 1995 | 7834741 | No |
2062 | 1321 | 1321.0 | 0.0 | 0.0 | A simple ultraviolet spectrophotometric method for the determination of protein. | W J Waddell | J Lab Clin Med | 1956 | 13346201 | Yes |
2063 | 5282 | 1320.5 | 125.2 | 31.3 | Quantitative monitoring of gene expression patterns with a complementary DNA microarray. | M Schena, D Shalon, R W Davis, P O Brown | Science | 1995 | 7569999 | Yes |
2064 | 2641 | 1320.5 | 56.73 | 28.4 | A guided tour into subcellular colocalization analysis in light microscopy. | S Bolte, F P Cordelières | J Microsc | 2006 | 17210054 | Yes |
2065 | 1320 | 1320.0 | 0.0 | 0.0 | Cellular resistance to infection. | G B Mackaness | J Exp Med | 1962 | 14467923 | Yes |
2066 | 2638 | 1319.0 | 0.0 | 0.0 | Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. | D H Figurski, D R Helinski | Proc Natl Acad Sci U S A | 1979 | 377280 | Yes |
2067 | 1319 | 1319.0 | 26.24 | 26.2 | Chromosomal translocations in human cancer. | T H Rabbitts | Nature | 1994 | 7969446 | No |
2068 | 3957 | 1319.0 | 90.9 | 30.3 | Osteoclast differentiation and activation. | William J Boyle, W Scott Simonet, David L Lacey | Nature | 2003 | 12748652 | No |
2069 | 1319 | 1319.0 | 0.0 | 0.0 | A quantitative immunochemical measure of the primary interaction between I BSA and antibody. | R S Farr | J Infect Dis | 1958 | 13611294 | Yes |
2070 | 1318 | 1318.0 | 47.09 | 47.1 | The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. | E J Khantzian | Harv Rev Psychiatry | 1997 | 9385000 | No |
2071 | 2635 | 1317.5 | 61.77 | 30.9 | The pathophysiology and treatment of sepsis. | Richard S Hotchkiss, Irene E Karl | N Engl J Med | 2003 | 12519925 | No |
2072 | 1317 | 1317.0 | 41.84 | 41.8 | The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. | L W Swanson | Brain Res Bull | 1982 | 6816390 | Yes |
2073 | 3949 | 1316.3 | 104.15 | 34.7 | Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. | B Fischl, M I Sereno, A M Dale | Neuroimage | 1999 | 9931269 | Yes |
2074 | 1316 | 1316.0 | 35.56 | 35.6 | Fibronectin and its receptors. | E Ruoslahti | Annu Rev Biochem | 1988 | 2972252 | No |
2075 | 1316 | 1316.0 | 44.94 | 44.9 | Gene flow and the geographic structure of natural populations. | M Slatkin | Science | 1987 | 3576198 | Yes |
2076 | 1316 | 1316.0 | 0.0 | 0.0 | Agammaglobulinemia. | O C Bruton | Pediatrics | 1952 | 14929630 | Yes |
2077 | 1315 | 1315.0 | 43.08 | 43.1 | History of the Rochester Epidemiology Project. | L J Melton | Mayo Clin Proc | 1996 | 8594285 | No |
2078 | 2630 | 1315.0 | 54.32 | 27.2 | Wnt signalling in stem cells and cancer. | Tannishtha Reya, Hans Clevers | Nature | 2005 | 15829953 | No |
2079 | 2629 | 1314.5 | 76.85 | 38.4 | Materials for electrochemical capacitors. | Patrice Simon, Yury Gogotsi | Nat Mater | 2008 | 18956000 | Yes |
2080 | 1314 | 1314.0 | 0.0 | 0.0 | Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. | W W Douglas | Br J Pharmacol | 1968 | 4882190 | No |
2081 | 1313 | 1313.0 | 33.82 | 33.8 | Thioredoxin and glutaredoxin systems. | A Holmgren | J Biol Chem | 1989 | 2668278 | No |
2082 | 1312 | 1312.0 | 34.78 | 34.8 | The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. | K Kuwajima | Proteins | 1989 | 2695928 | No |
2083 | 1312 | 1312.0 | 45.75 | 45.8 | Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. | K Anders Ericsson | Acad Med | 2004 | 15383395 | No |
2084 | 1312 | 1312.0 | 43.25 | 43.2 | The functional gastrointestinal disorders and the Rome III process. | Douglas A Drossman | Gastroenterology | 2006 | 16678553 | No |
2085 | 1312 | 1312.0 | 30.4 | 30.4 | Autophagy: from phenomenology to molecular understanding in less than a decade. | Daniel J Klionsky | Nat Rev Mol Cell Biol | 2007 | 17712358 | No |
2086 | 2623 | 1311.5 | 60.76 | 30.4 | Integrins and signal transduction pathways: the road taken. | E A Clark, J S Brugge | Science | 1995 | 7716514 | No |
2087 | 1311 | 1311.0 | 0.0 | 0.0 | Letter: Grading of angina pectoris. | L Campeau | Circulation | 1976 | 947585 | Yes |
2088 | 2620 | 1310.0 | 94.22 | 47.1 | Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. | M M Bradley, P J Lang | J Behav Ther Exp Psychiatry | 1994 | 7962581 | Yes |
2089 | 1310 | 1310.0 | 34.09 | 34.1 | Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. | Y Shai | Biochim Biophys Acta | 1999 | 10590302 | No |
2090 | 2620 | 1310.0 | 90.03 | 45.0 | The pathogenesis of rheumatoid arthritis. | Iain B McInnes, Georg Schett | N Engl J Med | 2011 | 22150039 | No |
2091 | 2619 | 1309.5 | 82.64 | 41.3 | A perspective on cancer cell metastasis. | Christine L Chaffer, Robert A Weinberg | Science | 2011 | 21436443 | No |
2092 | 1309 | 1309.0 | 41.8 | 41.8 | The phenomenon of the acute phase response. | I Kushner | Ann N Y Acad Sci | 1982 | 7046585 | No |
2093 | 2618 | 1309.0 | 61.03 | 30.5 | The RXR heterodimers and orphan receptors. | D J Mangelsdorf, R M Evans | Cell | 1995 | 8521508 | No |
2094 | 1309 | 1309.0 | 29.53 | 29.5 | A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. | Dale R Nyholt | Am J Hum Genet | 2004 | 14997420 | Yes |
2095 | 2616 | 1308.0 | 56.74 | 28.4 | The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. | M S Brown, J L Goldstein | Cell | 1997 | 9150132 | No |
2096 | 1307 | 1307.0 | 31.68 | 31.7 | Apoptosis in cancer therapy: crossing the threshold. | D E Fisher | Cell | 1994 | 8069905 | No |
2097 | 1307 | 1307.0 | 33.07 | 33.1 | Tobacco smoke carcinogens and lung cancer. | S S Hecht | J Natl Cancer Inst | 1999 | 10413421 | No |
2098 | 1307 | 1307.0 | 35.1 | 35.1 | The importance of the ratio of omega-6/omega-3 essential fatty acids. | A P Simopoulos | Biomed Pharmacother | 2002 | 12442909 | No |
2099 | 1307 | 1307.0 | 34.1 | 34.1 | N-heterocyclic carbenes: a new concept in organometallic catalysis. | Wolfgang A Herrmann | Angew Chem Int Ed Engl | 2002 | 19750753 | Yes |
2100 | 2613 | 1306.5 | 59.98 | 30.0 | Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. | E Y Chen, P H Seeburg | DNA | 1985 | 3996185 | Yes |
2101 | 2613 | 1306.5 | 78.16 | 39.1 | Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9164317 | Yes |
2102 | 1306 | 1306.0 | 36.39 | 36.4 | Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. | Michael F Holick | Am J Clin Nutr | 2004 | 15585788 | No |
2103 | 1305 | 1305.0 | 31.65 | 31.6 | Regulation of differentiation of vascular smooth muscle cells. | G K Owens | Physiol Rev | 1995 | 7624392 | No |
2104 | 1305 | 1305.0 | 27.74 | 27.7 | Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. | R I Morimoto | Genes Dev | 1998 | 9869631 | No |
2105 | 1305 | 1305.0 | 25.82 | 25.8 | Epithelial-mesenchymal transitions in development and pathologies. | Jean Paul Thiery | Curr Opin Cell Biol | 2003 | 14644200 | No |
2106 | 3914 | 1304.7 | 98.25 | 32.8 | The p53 tumour suppressor gene. | A J Levine, J Momand, C A Finlay | Nature | 1991 | 2046748 | No |
2107 | 1304 | 1304.0 | 50.81 | 50.8 | Free-radical mechanisms in tissue injury. | T F Slater | Biochem J | 1984 | 6383353 | No |
2108 | 1304 | 1304.0 | 32.92 | 32.9 | Upconversion and anti-Stokes processes with f and d ions in solids. | François Auzel | Chem Rev | 2004 | 14719973 | Yes |
2109 | 1304 | 1304.0 | 0.0 | 0.0 | The antidiuretic hormone and the factors which determine its release. | E B Verney | Proc R Soc Lond B Biol Sci | 1947 | 18918876 | Yes |
2110 | 2607 | 1303.5 | 82.82 | 41.4 | Astrocytes: biology and pathology. | Michael V Sofroniew, Harry V Vinters | Acta Neuropathol | 2010 | 20012068 | No |
2111 | 1303 | 1303.0 | 29.86 | 29.9 | Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. | W D Snider | Cell | 1994 | 8205613 | No |
2112 | 1303 | 1303.0 | 28.08 | 28.1 | Double identity for proteins of the Bcl-2 family. | J C Reed | Nature | 1997 | 9194558 | No |
2113 | 1303 | 1303.0 | 0.0 | 0.0 | The Relation Of Recombination To Mutational Advance. | H J Muller | Mutat Res | 1964 | 14195748 | Yes |
2114 | 1302 | 1302.0 | 50.52 | 50.5 | Presidential address, 1980. Surprise!...Surprise? | E Donchin | Psychophysiology | 1981 | 7280146 | Yes |
2115 | 1302 | 1302.0 | 33.33 | 33.3 | A molecular view of microbial diversity and the biosphere. | N R Pace | Science | 1997 | 9115194 | No |
2116 | 1302 | 1302.0 | 29.49 | 29.5 | Cancer of the ovary. | Stephen A Cannistra | N Engl J Med | 2004 | 15590954 | No |
2117 | 1302 | 1302.0 | 34.18 | 34.2 | Origin, biogenesis, and activity of plant microRNAs. | Olivier Voinnet | Cell | 2009 | 19239888 | No |
2118 | 2604 | 1302.0 | 76.48 | 38.2 | Lipid rafts as a membrane-organizing principle. | Daniel Lingwood, Kai Simons | Science | 2010 | 20044567 | No |
2119 | 2604 | 1302.0 | 77.02 | 38.5 | Molecular mechanisms of long noncoding RNAs. | Kevin C Wang, Howard Y Chang | Mol Cell | 2011 | 21925379 | No |
2120 | 3905 | 1301.7 | 0.0 | 0.0 | Improved method for the determination of blood glutathione. | E Beutler, O Duron, B M Kelly | J Lab Clin Med | 1963 | 13967893 | Yes |
2121 | 2603 | 1301.5 | 52.23 | 26.1 | Autophagy as a regulated pathway of cellular degradation. | D J Klionsky, S D Emr | Science | 2000 | 11099404 | No |
2122 | 1301 | 1301.0 | 37.22 | 37.2 | The matrix-degrading metalloproteinases. | L M Matrisian | Bioessays | 1992 | 1445287 | No |
2123 | 1301 | 1301.0 | 36.0 | 36.0 | A note on robust variance estimation for cluster-correlated data. | R L Williams | Biometrics | 2000 | 10877330 | Yes |
2124 | 1301 | 1301.0 | 30.67 | 30.7 | Molecular basis of long-term plasticity underlying addiction. | E J Nestler | Nat Rev Neurosci | 2001 | 11252991 | No |
2125 | 1301 | 1301.0 | 34.46 | 34.5 | Interoception: the sense of the physiological condition of the body. | A D Craig | Curr Opin Neurobiol | 2003 | 12965300 | No |
2126 | 1300 | 1300.0 | 24.39 | 24.4 | Chromatin modification and epigenetic reprogramming in mammalian development. | En Li | Nat Rev Genet | 2002 | 12209141 | No |
2127 | 1300 | 1300.0 | 49.23 | 49.2 | Functional and effective connectivity: a review. | Karl J Friston | Brain Connect | 2011 | 22432952 | No |
2128 | 3898 | 1299.3 | 140.66 | 46.9 | Structure-antioxidant activity relationships of flavonoids and phenolic acids. | C A Rice-Evans, N J Miller, G Paganga | Free Radic Biol Med | 1996 | 8743980 | Yes |
2129 | 2598 | 1299.0 | 0.0 | 0.0 | Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. | L F Berkman, S L Syme | Am J Epidemiol | 1979 | 425958 | Yes |
2130 | 1298 | 1298.0 | 41.88 | 41.9 | Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. | A A Grace | Neuroscience | 1991 | 1676137 | No |
2131 | 1298 | 1298.0 | 26.68 | 26.7 | Natively unfolded proteins: a point where biology waits for physics. | Vladimir N Uversky | Protein Sci | 2002 | 11910019 | No |
2132 | 1297 | 1297.0 | 47.27 | 47.3 | A Social Neuroscience Perspective on Adolescent Risk-Taking. | Laurence Steinberg | Dev Rev | 2008 | 18509515 | Yes |
2133 | 2593 | 1296.5 | 0.0 | 0.0 | A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. | J A Horne, O Ostberg | Int J Chronobiol | 1976 | 1027738 | Yes |
2134 | 2593 | 1296.5 | 0.0 | 0.0 | A new scale of social desirability independent of psychopathology. | D P Crowne, D Marlowe | J Consult Psychol | 1960 | 13813058 | Yes |
2135 | 2589 | 1294.5 | 57.46 | 28.7 | NMR View: A computer program for the visualization and analysis of NMR data. | B A Johnson, R A Blevins | J Biomol NMR | 1994 | 22911360 | Yes |
2136 | 1294 | 1294.0 | 0.0 | 0.0 | Mate selection-a selection for a handicap. | A Zahavi | J Theor Biol | 1975 | 1195756 | Yes |
2137 | 1294 | 1294.0 | 29.15 | 29.1 | The ATP synthase--a splendid molecular machine. | P D Boyer | Annu Rev Biochem | 1997 | 9242922 | No |
2138 | 2588 | 1294.0 | 54.99 | 27.5 | Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. | J M Kyriakis, J Avruch | Physiol Rev | 2001 | 11274345 | No |
2139 | 1294 | 1294.0 | 44.58 | 44.6 | The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. | Poul Erik Petersen | Community Dent Oral Epidemiol | 2003 | 15015736 | Yes |
2140 | 2586 | 1293.0 | 0.0 | 0.0 | A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. | R L Juliano, V Ling | Biochim Biophys Acta | 1976 | 990323 | Yes |
2141 | 1293 | 1293.0 | 55.99 | 56.0 | The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. | E J Khantzian | Am J Psychiatry | 1985 | 3904487 | No |
2142 | 2586 | 1293.0 | 89.26 | 44.6 | Thermodynamics of protein association reactions: forces contributing to stability. | P D Ross, S Subramanian | Biochemistry | 1981 | 7248271 | Yes |
2143 | 1293 | 1293.0 | 22.31 | 22.3 | Cancer. Addiction to oncogenes--the Achilles heal of cancer. | I Bernard Weinstein | Science | 2002 | 12098689 | No |
2144 | 2585 | 1292.5 | 60.02 | 30.0 | Disruption of epithelial cell-matrix interactions induces apoptosis. | S M Frisch, H Francis | J Cell Biol | 1994 | 8106557 | Yes |
2145 | 1292 | 1292.0 | 28.26 | 28.3 | The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. | G B Morin | Cell | 1989 | 2805070 | Yes |
2146 | 2584 | 1292.0 | 61.92 | 31.0 | Production of single-stranded plasmid DNA. | J Vieira, J Messing | Methods Enzymol | 1987 | 3323803 | Yes |
2147 | 1292 | 1292.0 | 39.99 | 40.0 | Recent developments in isocyanide based multicomponent reactions in applied chemistry. | Alexander Dömling | Chem Rev | 2006 | 16402771 | No |
2148 | 1291 | 1291.0 | 85.22 | 85.2 | The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. | F Denis | Spine (Phila Pa 1976) | 1983 | 6670016 | Yes |
2149 | 1291 | 1291.0 | 36.69 | 36.7 | The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. | R G Gerrity | Am J Pathol | 1981 | 7234961 | Yes |
2150 | 2582 | 1291.0 | 60.32 | 30.2 | A comparison of bayesian methods for haplotype reconstruction from population genotype data. | Matthew Stephens, Peter Donnelly | Am J Hum Genet | 2003 | 14574645 | Yes |
2151 | 1291 | 1291.0 | 32.94 | 32.9 | Drug-induced prolongation of the QT interval. | Dan M Roden | N Engl J Med | 2004 | 14999113 | No |
2152 | 1290 | 1290.0 | 35.6 | 35.6 | The epidemiology of venous thromboembolism. | Richard H White | Circulation | 2003 | 12814979 | No |
2153 | 2578 | 1289.0 | 0.0 | 0.0 | Epidermal growth factor. | G Carpenter, S Cohen | Annu Rev Biochem | 1979 | 382984 | No |
2154 | 1289 | 1289.0 | 31.29 | 31.3 | Receptors for epidermal growth factor and other polypeptide mitogens. | G Carpenter | Annu Rev Biochem | 1987 | 3039909 | No |
2155 | 1289 | 1289.0 | 0.0 | 0.0 | Hippocampal electrical activity and voluntary movement in the rat. | C H Vanderwolf | Electroencephalogr Clin Neurophysiol | 1969 | 4183562 | Yes |
2156 | 1289 | 1289.0 | 36.56 | 36.6 | Synergy, antagonism, and what the chequerboard puts between them. | F C Odds | J Antimicrob Chemother | 2003 | 12805255 | No |
2157 | 1289 | 1289.0 | 56.27 | 56.3 | Cognitive reserve in ageing and Alzheimer's disease. | Yaakov Stern | Lancet Neurol | 2012 | 23079557 | No |
2158 | 3866 | 1288.7 | 184.11 | 61.4 | Risk factors for falls among elderly persons living in the community. | M E Tinetti, M Speechley, S F Ginter | N Engl J Med | 1988 | 3205267 | Yes |
2159 | 1288 | 1288.0 | 23.95 | 23.9 | The snail superfamily of zinc-finger transcription factors. | M Angela Nieto | Nat Rev Mol Cell Biol | 2002 | 11994736 | No |
2160 | 1287 | 1287.0 | 24.29 | 24.3 | CD95's deadly mission in the immune system. | P H Krammer | Nature | 2000 | 11048730 | No |
2161 | 1287 | 1287.0 | 37.64 | 37.6 | Bioactive microbial metabolites. | János Bérdy | J Antibiot (Tokyo) | 2005 | 15813176 | No |
2162 | 1287 | 1287.0 | 29.45 | 29.4 | Critical period plasticity in local cortical circuits. | Takao K Hensch | Nat Rev Neurosci | 2005 | 16261181 | No |
2163 | 2573 | 1286.5 | 77.86 | 38.9 | What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. | J Zhang, K F Yu | JAMA | 1998 | 9832001 | Yes |
2164 | 2572 | 1286.0 | 0.0 | 0.0 | Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. | J A Ledbetter, L A Herzenberg | Immunol Rev | 1979 | 398327 | No |
2165 | 1286 | 1286.0 | 40.64 | 40.6 | A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. | Ozcan Erel | Clin Biochem | 2004 | 15003729 | Yes |
2166 | 1286 | 1286.0 | 44.04 | 44.0 | Stress and disorders of the stress system. | George P Chrousos | Nat Rev Endocrinol | 2009 | 19488073 | No |
2167 | 1286 | 1286.0 | 0.0 | 0.0 | Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. | H M Kalckar | J Biol Chem | 1947 | 20285041 | Yes |
2168 | 3856 | 1285.3 | 104.15 | 34.7 | The metabolic syndrome. | Robert H Eckel, Scott M Grundy, Paul Z Zimmet | Lancet | 2005 | 15836891 | No |
2169 | 3853 | 1284.3 | 120.18 | 40.1 | Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. | S van der Linden, H A Valkenburg, A Cats | Arthritis Rheum | 1984 | 6231933 | Yes |
2170 | 1284 | 1284.0 | 34.27 | 34.3 | Phylogenies from molecular sequences: inference and reliability. | J Felsenstein | Annu Rev Genet | 1988 | 3071258 | No |
2171 | 1284 | 1284.0 | 48.59 | 48.6 | UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. | D W Russell | J Pers Assess | 1996 | 8576833 | Yes |
2172 | 5136 | 1284.0 | 127.94 | 32.0 | Improved prediction of signal peptides: SignalP 3.0. | Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren Brunak | J Mol Biol | 2004 | 15223320 | Yes |
2173 | 1284 | 1284.0 | 61.67 | 61.7 | Whatever next? Predictive brains, situated agents, and the future of cognitive science. | Andy Clark | Behav Brain Sci | 2013 | 23663408 | No |
2174 | 5134 | 1283.5 | 129.58 | 32.4 | The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. | Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten Schwede | Bioinformatics | 2006 | 16301204 | Yes |
2175 | 1283 | 1283.0 | 51.67 | 51.7 | Reliability and factor analysis of the Epworth Sleepiness Scale. | M W Johns | Sleep | 1992 | 1519015 | Yes |
2176 | 1283 | 1283.0 | 0.0 | 0.0 | Electrophoretic separation of plasma lipoproteins in agarose gel. | R P Noble | J Lipid Res | 1968 | 4176473 | Yes |
2177 | 1283 | 1283.0 | 44.82 | 44.8 | Functional organization of central pathways regulating the cardiovascular system. | R A Dampney | Physiol Rev | 1994 | 8171117 | No |
2178 | 1283 | 1283.0 | 33.92 | 33.9 | The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. | T Szkudelski | Physiol Res | 2001 | 11829314 | No |
2179 | 2565 | 1282.5 | 0.0 | 0.0 | Regulatory sequences involved in the promotion and termination of RNA transcription. | M Rosenberg, D Court | Annu Rev Genet | 1979 | 94251 | No |
2180 | 1282 | 1282.0 | 0.0 | 0.0 | Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. | J H Luft | Anat Rec | 1971 | 4108333 | Yes |
2181 | 1282 | 1282.0 | 0.0 | 0.0 | Cardiovascular and renal actions of dopamine: potential clinical applications. | L I Goldberg | Pharmacol Rev | 1972 | 4554480 | No |
2182 | 1282 | 1282.0 | 0.0 | 0.0 | A New Weighting System For Mean Surface Temperature Of The Human Body. | N L Ramanathan | J Appl Physiol | 1964 | 14173555 | Yes |
2183 | 1282 | 1282.0 | 42.78 | 42.8 | Formation of glasses from liquids and biopolymers. | C A Angell | Science | 1995 | 17770101 | Yes |
2184 | 2563 | 1281.5 | 0.0 | 0.0 | A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. | B G Durie, S E Salmon | Cancer | 1975 | 1182674 | Yes |
2185 | 5126 | 1281.5 | 298.68 | 74.7 | IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. | Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang Minh | Mol Biol Evol | 2015 | 25371430 | Yes |
2186 | 1281 | 1281.0 | 24.28 | 24.3 | Antigen-specific interaction between T and B cells. | A Lanzavecchia | Nature | 1985 | 3157869 | Yes |
2187 | 1281 | 1281.0 | 0.0 | 0.0 | Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. | A Böyum | Scand J Clin Lab Invest Suppl | 1968 | 4179066 | Yes |
2188 | 1280 | 1280.0 | 40.32 | 40.3 | Biological basis of the behavior of sick animals. | B L Hart | Neurosci Biobehav Rev | 1988 | 3050629 | No |
2189 | 1280 | 1280.0 | 42.99 | 43.0 | SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. | B P O'Connor | Behav Res Methods Instrum Comput | 2000 | 11029811 | Yes |
2190 | 1280 | 1280.0 | 0.0 | 0.0 | Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. | Russell Lande | Evolution | 1979 | 28568194 | Yes |
2191 | 1279 | 1279.0 | 23.24 | 23.2 | Regulatory T cells: key controllers of immunologic self-tolerance. | S Sakaguchi | Cell | 2000 | 10850488 | No |
2192 | 1279 | 1279.0 | 31.02 | 31.0 | Cell signaling. H2O2, a necessary evil for cell signaling. | Sue Goo Rhee | Science | 2006 | 16809515 | Yes |
2193 | 1279 | 1279.0 | 38.44 | 38.4 | The debate over dopamine's role in reward: the case for incentive salience. | Kent C Berridge | Psychopharmacology (Berl) | 2007 | 17072591 | No |
2194 | 1278 | 1278.0 | 0.0 | 0.0 | The prevalence of 'alexithymic' characteristics in psychosomatic patients. | P E Sifneos | Psychother Psychosom | 1973 | 4770536 | Yes |
2195 | 1278 | 1278.0 | 46.92 | 46.9 | Substance P. | B Pernow | Pharmacol Rev | 1983 | 6196797 | No |
2196 | 1278 | 1278.0 | 24.47 | 24.5 | The significance of responses of the genome to challenge. | B McClintock | Science | 1984 | 15739260 | No |
2197 | 1277 | 1277.0 | 34.66 | 34.7 | Signaling through phosphatidylcholine breakdown. | J H Exton | J Biol Chem | 1990 | 2104616 | No |
2198 | 2554 | 1277.0 | 47.64 | 23.8 | New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. | R D Gietz, A Sugino | Gene | 1988 | 3073106 | Yes |
2199 | 1277 | 1277.0 | 30.74 | 30.7 | Lymphokine production by human T cells in disease states. | S Romagnani | Annu Rev Immunol | 1994 | 8011282 | No |
2200 | 1277 | 1277.0 | 34.86 | 34.9 | Understanding biofilm resistance to antibacterial agents. | David Davies | Nat Rev Drug Discov | 2003 | 12563302 | No |
2201 | 2553 | 1276.5 | 43.31 | 21.7 | Genetic transformation of Drosophila with transposable element vectors. | G M Rubin, A C Spradling | Science | 1982 | 6289436 | Yes |
2202 | 2552 | 1276.0 | 0.0 | 0.0 | Functions of lysosomes. | C De Duve, R Wattiaux | Annu Rev Physiol | 1966 | 5322983 | No |
2203 | 1276 | 1276.0 | 29.08 | 29.1 | Target-oriented and diversity-oriented organic synthesis in drug discovery. | S L Schreiber | Science | 2000 | 10720315 | No |
2204 | 1276 | 1276.0 | 23.19 | 23.2 | Protein modification by SUMO. | Erica S Johnson | Annu Rev Biochem | 2004 | 15189146 | No |
2205 | 2551 | 1275.5 | 0.0 | 0.0 | Glutathione peroxidase activity in selenium-deficient rat liver. | R A Lawrence, R F Burk | Biochem Biophys Res Commun | 1976 | 971321 | Yes |
2206 | 1275 | 1275.0 | 42.05 | 42.0 | Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. | Thomas Heberer | Toxicol Lett | 2002 | 11988354 | Yes |
2207 | 2549 | 1274.5 | 55.49 | 27.7 | Liver regeneration. | G K Michalopoulos, M C DeFrances | Science | 1997 | 9082986 | No |
2208 | 3823 | 1274.3 | 102.46 | 34.2 | How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. | R M Sapolsky, L M Romero, A U Munck | Endocr Rev | 2000 | 10696570 | No |
2209 | 1274 | 1274.0 | 22.81 | 22.8 | Clonal selection and learning in the antibody system. | K Rajewsky | Nature | 1996 | 8657279 | No |
2210 | 1274 | 1274.0 | 38.92 | 38.9 | Strong localization of photons in certain disordered dielectric superlattices. | John | Phys Rev Lett | 1987 | 10034761 | Yes |
2211 | 1274 | 1274.0 | 35.56 | 35.6 | Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. | P Lips | Endocr Rev | 2001 | 11493580 | No |
2212 | 1274 | 1274.0 | 39.92 | 39.9 | Understanding organofluorine chemistry. An introduction to the C-F bond. | David O'Hagan | Chem Soc Rev | 2008 | 18197347 | No |
2213 | 2548 | 1274.0 | 97.29 | 48.6 | Genome editing. The new frontier of genome engineering with CRISPR-Cas9. | Jennifer A Doudna, Emmanuelle Charpentier | Science | 2014 | 25430774 | No |
2214 | 2547 | 1273.5 | 0.0 | 0.0 | The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. | J Shine, L Dalgarno | Proc Natl Acad Sci U S A | 1974 | 4598299 | Yes |
2215 | 1273 | 1273.0 | 38.94 | 38.9 | Diversity and ubiquity of K channels. | B Rudy | Neuroscience | 1988 | 2457185 | No |
2216 | 1273 | 1273.0 | 47.96 | 48.0 | Quantitative methods in the review of epidemiologic literature. | S Greenland | Epidemiol Rev | 1987 | 3678409 | Yes |
2217 | 1273 | 1273.0 | 40.51 | 40.5 | Ordinary magic. Resilience processes in development. | A S Masten | Am Psychol | 2001 | 11315249 | Yes |
2218 | 1273 | 1273.0 | 33.93 | 33.9 | Hemispheric asymmetry reduction in older adults: the HAROLD model. | Roberto Cabeza | Psychol Aging | 2002 | 11931290 | No |
2219 | 1273 | 1273.0 | 33.75 | 33.8 | Clinical features of metastatic bone disease and risk of skeletal morbidity. | Robert E Coleman | Clin Cancer Res | 2006 | 17062708 | No |
2220 | 1273 | 1273.0 | 28.25 | 28.2 | Maintenance of C. elegans. | Theresa Stiernagle | WormBook | 2006 | 18050451 | No |
2221 | 1272 | 1272.0 | 33.74 | 33.7 | Supported membranes: scientific and practical applications. | E Sackmann | Science | 1996 | 8539599 | No |
2222 | 1272 | 1272.0 | 29.91 | 29.9 | Mitochondria: dynamic organelles in disease, aging, and development. | David C Chan | Cell | 2006 | 16814712 | No |
2223 | 1271 | 1271.0 | 48.08 | 48.1 | The life and times of the Enterococcus. | B E Murray | Clin Microbiol Rev | 1990 | 2404568 | No |
2224 | 2542 | 1271.0 | 96.08 | 48.0 | Universal chemical assay for the detection and determination of siderophores. | B Schwyn, J B Neilands | Anal Biochem | 1987 | 2952030 | Yes |
2225 | 2542 | 1271.0 | 89.65 | 44.8 | The framing of decisions and the psychology of choice. | A Tversky, D Kahneman | Science | 1981 | 7455683 | Yes |
2226 | 3813 | 1271.0 | 105.7 | 35.2 | TCS: a computer program to estimate gene genealogies. | M Clement, D Posada, K A Crandall | Mol Ecol | 2000 | 11050560 | Yes |
2227 | 1271 | 1271.0 | 28.26 | 28.3 | Stability and flexibility of epigenetic gene regulation in mammalian development. | Wolf Reik | Nature | 2007 | 17522676 | No |
2228 | 2542 | 1271.0 | 166.79 | 83.4 | Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. | Ivica Letunic, Peer Bork | Nucleic Acids Res | 2016 | 27095192 | Yes |
2229 | 2541 | 1270.5 | 0.0 | 0.0 | Establishment and characterization of a human histiocytic lymphoma cell line (U-937). | C Sundström, K Nilsson | Int J Cancer | 1976 | 178611 | Yes |
2230 | 1270 | 1270.0 | 42.01 | 42.0 | Somatostatin. | S Reichlin | N Engl J Med | 1983 | 6139753 | No |
2231 | 1270 | 1270.0 | 33.89 | 33.9 | The aryl hydrocarbon receptor complex. | O Hankinson | Annu Rev Pharmacol Toxicol | 1995 | 7598497 | No |
2232 | 2537 | 1268.5 | 69.57 | 34.8 | Abdominal obesity and metabolic syndrome. | Jean-Pierre Després, Isabelle Lemieux | Nature | 2006 | 17167477 | No |
2233 | 1268 | 1268.0 | 63.28 | 63.3 | Chronic illness as biographical disruption. | M Bury | Sociol Health Illn | 1982 | 10260456 | Yes |
2234 | 3804 | 1268.0 | 114.35 | 38.1 | I-TASSER: a unified platform for automated protein structure and function prediction. | Ambrish Roy, Alper Kucukural, Yang Zhang | Nat Protoc | 2010 | 20360767 | Yes |
2235 | 1268 | 1268.0 | 39.76 | 39.8 | Graphene transistors. | Frank Schwierz | Nat Nanotechnol | 2010 | 20512128 | Yes |
2236 | 3803 | 1267.7 | 94.67 | 31.6 | Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. | Daniel Falush, Matthew Stephens, Jonathan K Pritchard | Genetics | 2003 | 12930761 | Yes |
2237 | 2532 | 1266.0 | 78.16 | 39.1 | miRBase: integrating microRNA annotation and deep-sequencing data. | Ana Kozomara, Sam Griffiths-Jones | Nucleic Acids Res | 2011 | 21037258 | Yes |
2238 | 1266 | 1266.0 | 48.02 | 48.0 | Asthma phenotypes: the evolution from clinical to molecular approaches. | Sally E Wenzel | Nat Med | 2012 | 22561835 | No |
2239 | 2531 | 1265.5 | 62.45 | 31.2 | Multipoint quantitative-trait linkage analysis in general pedigrees. | L Almasy, J Blangero | Am J Hum Genet | 1998 | 9545414 | Yes |
2240 | 1265 | 1265.0 | 0.0 | 0.0 | The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. | R G Khalifah | J Biol Chem | 1971 | 4994926 | Yes |
2241 | 2530 | 1265.0 | 49.86 | 24.9 | Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. | M Fried, D M Crothers | Nucleic Acids Res | 1981 | 6275366 | Yes |
2242 | 11380 | 1264.4 | 362.92 | 40.3 | The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. | D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C Dunbar | J Clin Psychiatry | 1998 | 9881538 | No |
2243 | 2528 | 1264.0 | 0.0 | 0.0 | Prediction of the secondary structure of proteins from their amino acid sequence. | P Y Chou, G D Fasman | Adv Enzymol Relat Areas Mol Biol | 1978 | 364941 | No |
2244 | 2528 | 1264.0 | 0.0 | 0.0 | A rapid, sensitive, and specific method for the determination of protein in dilute solution. | W Schaffner, C Weissmann | Anal Biochem | 1973 | 4128882 | Yes |
2245 | 1264 | 1264.0 | 67.87 | 67.9 | The determinants of parenting: a process model. | J Belsky | Child Dev | 1984 | 6705636 | Yes |
2246 | 1264 | 1264.0 | 44.43 | 44.4 | Aging, cellular senescence, and cancer. | Judith Campisi | Annu Rev Physiol | 2013 | 23140366 | No |
2247 | 2527 | 1263.5 | 83.97 | 42.0 | The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. | W R Gibb, A J Lees | J Neurol Neurosurg Psychiatry | 1988 | 2841426 | No |
2248 | 2526 | 1263.0 | 63.15 | 31.6 | Inflammation, stress, and diabetes. | Kathryn E Wellen, Gökhan S Hotamisligil | J Clin Invest | 2005 | 15864338 | No |
2249 | 5047 | 1261.8 | 151.9 | 38.0 | Reversible middle cerebral artery occlusion without craniectomy in rats. | E Z Longa, P R Weinstein, S Carlson, R Cummins | Stroke | 1989 | 2643202 | Yes |
2250 | 3783 | 1261.0 | 84.36 | 28.1 | Multidrug resistance in cancer: role of ATP-dependent transporters. | Michael M Gottesman, Tito Fojo, Susan E Bates | Nat Rev Cancer | 2002 | 11902585 | No |
2251 | 1261 | 1261.0 | 37.62 | 37.6 | The origins of the developmental origins theory. | D J P Barker | J Intern Med | 2007 | 17444880 | No |
2252 | 1260 | 1260.0 | 52.56 | 52.6 | Error in medicine. | L L Leape | JAMA | 1994 | 7503827 | Yes |
2253 | 1260 | 1260.0 | 38.39 | 38.4 | Osteoblast adhesion on biomaterials. | K Anselme | Biomaterials | 2000 | 10711964 | No |
2254 | 3780 | 1260.0 | 79.52 | 26.5 | The versatility and universality of calcium signalling. | M J Berridge, P Lipp, M D Bootman | Nat Rev Mol Cell Biol | 2000 | 11413485 | No |
2255 | 2518 | 1259.0 | 73.21 | 36.6 | Regulation of chromatin by histone modifications. | Andrew J Bannister, Tony Kouzarides | Cell Res | 2011 | 21321607 | No |
2256 | 6293 | 1258.6 | 0.0 | 0.0 | Enzymatic determination of total serum cholesterol. | C C Allain, L S Poon, C S Chan, W Richmond, P C Fu | Clin Chem | 1974 | 4818200 | Yes |
2257 | 1258 | 1258.0 | 29.08 | 29.1 | Chemistry and biology of the immunophilins and their immunosuppressive ligands. | S L Schreiber | Science | 1991 | 1702904 | No |
2258 | 1258 | 1258.0 | 27.54 | 27.5 | Codon usage and tRNA content in unicellular and multicellular organisms. | T Ikemura | Mol Biol Evol | 1985 | 3916708 | No |
2259 | 1258 | 1258.0 | 0.0 | 0.0 | Structure and function of intercellular junctions. | L A Staehelin | Int Rev Cytol | 1974 | 4611943 | No |
2260 | 1258 | 1258.0 | 44.97 | 45.0 | Carnitine--metabolism and functions. | J Bremer | Physiol Rev | 1983 | 6361812 | No |
2261 | 2516 | 1258.0 | 57.64 | 28.8 | Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. | Joshua E Elias, Steven P Gygi | Nat Methods | 2007 | 17327847 | Yes |
2262 | 1257 | 1257.0 | 0.0 | 0.0 | Strategy and tactics in protein chemistry. | B S Hartley | Biochem J | 1970 | 4923920 | No |
2263 | 1257 | 1257.0 | 26.19 | 26.2 | SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. | S V Evans | J Mol Graph | 1993 | 8347566 | Yes |
2264 | 3769 | 1256.3 | 145.19 | 48.4 | CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. | Teresa C Horan, Mary Andrus, Margaret A Dudeck | Am J Infect Control | 2008 | 18538699 | No |
2265 | 1256 | 1256.0 | 43.24 | 43.2 | Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. | R Lotan | Biochim Biophys Acta | 1980 | 6989400 | No |
2266 | 1256 | 1256.0 | 31.87 | 31.9 | Apoptosis. | J J Cohen | Immunol Today | 1993 | 8466628 | No |
2267 | 1256 | 1256.0 | 33.09 | 33.1 | Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. | R M Sapolsky | Arch Gen Psychiatry | 2000 | 11015810 | No |
2268 | 1256 | 1256.0 | 0.0 | 0.0 | Limitations of the application of fourfold table analysis to hospital data. | J Berkson | Biometrics | 1946 | 21001024 | Yes |
2269 | 2511 | 1255.5 | 59.04 | 29.5 | Cellular senescence: when bad things happen to good cells. | Judith Campisi, Fabrizio d'Adda di Fagagna | Nat Rev Mol Cell Biol | 2007 | 17667954 | No |
2270 | 1255 | 1255.0 | 26.32 | 26.3 | Signal transduction via the MAP kinases: proceed at your own RSK. | J Blenis | Proc Natl Acad Sci U S A | 1993 | 8392180 | No |
2271 | 1255 | 1255.0 | 37.94 | 37.9 | Treatment of infections associated with surgical implants. | Rabih O Darouiche | N Engl J Med | 2004 | 15070792 | No |
2272 | 2509 | 1254.5 | 67.41 | 33.7 | Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. | J L Weber, P E May | Am J Hum Genet | 1989 | 2916582 | Yes |
2273 | 2509 | 1254.5 | 98.75 | 49.4 | The integrative review: updated methodology. | Robin Whittemore, Kathleen Knafl | J Adv Nurs | 2005 | 16268861 | Yes |
2274 | 3763 | 1254.3 | 82.2 | 27.4 | A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. | R Medzhitov, P Preston-Hurlburt, C A Janeway | Nature | 1997 | 9237759 | Yes |
2275 | 2507 | 1253.5 | 52.64 | 26.3 | Short-term synaptic plasticity. | Robert S Zucker, Wade G Regehr | Annu Rev Physiol | 2002 | 11826273 | No |
2276 | 7520 | 1253.3 | 276.59 | 46.1 | TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. | Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg | Genome Biol | 2013 | 23618408 | Yes |
2277 | 1253 | 1253.0 | 25.84 | 25.8 | Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. | R H Schwartz | Cell | 1992 | 1335362 | No |
2278 | 7514 | 1252.3 | 204.47 | 34.1 | Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. | Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur Wheeler | N Engl J Med | 2000 | 10793162 | Yes |
2279 | 1252 | 1252.0 | 28.57 | 28.6 | Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. | T A Springer | Annu Rev Physiol | 1995 | 7778885 | No |
2280 | 1252 | 1252.0 | 46.74 | 46.7 | Phase retrieval algorithms: a comparison. | J R Fienup | Appl Opt | 1982 | 20396114 | Yes |
2281 | 2503 | 1251.5 | 80.64 | 40.3 | Porosity of 3D biomaterial scaffolds and osteogenesis. | Vassilis Karageorgiou, David Kaplan | Biomaterials | 2005 | 15860204 | No |
2282 | 1251 | 1251.0 | 28.35 | 28.4 | Life, death, and the pursuit of apoptosis. | E White | Genes Dev | 1996 | 8557188 | No |
2283 | 1250 | 1250.0 | 45.59 | 45.6 | The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. | A Raine | Schizophr Bull | 1991 | 1805349 | Yes |
2284 | 2500 | 1250.0 | 58.19 | 29.1 | DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. | S Tabor, C C Richardson | Proc Natl Acad Sci U S A | 1987 | 3474623 | Yes |
2285 | 8748 | 1249.7 | 269.94 | 38.6 | Cancer statistics, 2008. | Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J Thun | CA Cancer J Clin | 2008 | 18287387 | Yes |
2286 | 2499 | 1249.5 | 55.5 | 27.8 | Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. | M Zuker, P Stiegler | Nucleic Acids Res | 1981 | 6163133 | Yes |
2287 | 2498 | 1249.0 | 55.81 | 27.9 | Mitochondrial control of cell death. | G Kroemer, J C Reed | Nat Med | 2000 | 10802706 | No |
2288 | 1249 | 1249.0 | 30.67 | 30.7 | Proinflammatory cytokines. | C A Dinarello | Chest | 2000 | 10936147 | No |
2289 | 1249 | 1249.0 | 26.77 | 26.8 | The many faces of macrophage activation. | David M Mosser | J Leukoc Biol | 2003 | 12554797 | No |
2290 | 2497 | 1248.5 | 66.43 | 33.2 | Apoptosis, oncosis, and necrosis. An overview of cell death. | G Majno, I Joris | Am J Pathol | 1995 | 7856735 | No |
2291 | 2497 | 1248.5 | 78.89 | 39.4 | Genome regulation by long noncoding RNAs. | John L Rinn, Howard Y Chang | Annu Rev Biochem | 2012 | 22663078 | No |
2292 | 6241 | 1248.2 | 192.74 | 38.5 | Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. | Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E Walters | Arch Gen Psychiatry | 2005 | 15939839 | Yes |
2293 | 1248 | 1248.0 | 0.0 | 0.0 | The intraclass correlation coefficient as a measure of reliability. | J J Bartko | Psychol Rep | 1966 | 5942109 | Yes |
2294 | 2496 | 1248.0 | 56.01 | 28.0 | LTP and LTD: an embarrassment of riches. | Robert C Malenka, Mark F Bear | Neuron | 2004 | 15450156 | No |
2295 | 2495 | 1247.5 | 75.67 | 37.8 | The Measurement Of Selection On Correlated Characters. | Russell Lande, Stevan J Arnold | Evolution | 1983 | 28556011 | Yes |
2296 | 1247 | 1247.0 | 30.65 | 30.6 | Short-term synaptic plasticity. | R S Zucker | Annu Rev Neurosci | 1989 | 2648947 | No |
2297 | 1247 | 1247.0 | 0.0 | 0.0 | The origin of the genetic code. | F H Crick | J Mol Biol | 1968 | 4887876 | Yes |
2298 | 1247 | 1247.0 | 30.42 | 30.4 | Papillomavirus infections--a major cause of human cancers. | H zur Hausen | Biochim Biophys Acta | 1996 | 8876633 | No |
2299 | 1247 | 1247.0 | 27.62 | 27.6 | HIF-1: mediator of physiological and pathophysiological responses to hypoxia. | G L Semenza | J Appl Physiol (1985) | 2000 | 10749844 | No |
2300 | 2494 | 1247.0 | 70.8 | 35.4 | Bronchopulmonary dysplasia. | A H Jobe, E Bancalari | Am J Respir Crit Care Med | 2001 | 11401896 | No |
2301 | 1247 | 1247.0 | 35.5 | 35.5 | Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. | E B Hunziker | Osteoarthritis Cartilage | 2002 | 12056848 | No |
2302 | 1247 | 1247.0 | 38.39 | 38.4 | Multiple imputation of discrete and continuous data by fully conditional specification. | Stef van Buuren | Stat Methods Med Res | 2007 | 17621469 | Yes |
2303 | 2494 | 1247.0 | 62.28 | 31.1 | The DNA damage response: making it safe to play with knives. | Alberto Ciccia, Stephen J Elledge | Mol Cell | 2010 | 20965415 | No |
2304 | 2492 | 1246.0 | 46.11 | 23.1 | Rab proteins as membrane organizers. | M Zerial, H McBride | Nat Rev Mol Cell Biol | 2001 | 11252952 | No |
2305 | 2492 | 1246.0 | 65.12 | 32.6 | Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. | M P Lutolf, J A Hubbell | Nat Biotechnol | 2005 | 15637621 | No |
2306 | 1246 | 1246.0 | 42.01 | 42.0 | Signal transduction by reactive oxygen species. | Toren Finkel | J Cell Biol | 2011 | 21746850 | No |
2307 | 1245 | 1245.0 | 20.76 | 20.8 | Antigen receptor tail clue. | M Reth | Nature | 1989 | 2927501 | Yes |
2308 | 1245 | 1245.0 | 23.24 | 23.2 | c-Myc target genes involved in cell growth, apoptosis, and metabolism. | C V Dang | Mol Cell Biol | 1999 | 9858526 | No |
2309 | 1245 | 1245.0 | 25.87 | 25.9 | Searching for genetic determinants in the new millennium. | N J Risch | Nature | 2000 | 10866211 | No |
2310 | 1245 | 1245.0 | 0.0 | 0.0 | The effective period of preventive antibiotic action in experimental incisions and dermal lesions. | J F Burke | Surgery | 1961 | 16722001 | Yes |
2311 | 1245 | 1245.0 | 0.0 | 0.0 | On the local reactions of the arterial wall to changes of internal pressure. | W M Bayliss | J Physiol | 1902 | 16992618 | Yes |
2312 | 6222 | 1244.4 | 239.17 | 47.8 | Evidence based medicine: what it is and what it isn't. | D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S Richardson | BMJ | 1996 | 8555924 | No |
2313 | 1244 | 1244.0 | 40.34 | 40.3 | The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. | J L Cummings | Neurology | 1997 | 9153155 | No |
2314 | 1244 | 1244.0 | 41.61 | 41.6 | The law of attrition. | Gunther Eysenbach | J Med Internet Res | 2005 | 15829473 | Yes |
2315 | 1243 | 1243.0 | 0.0 | 0.0 | Bee and wasp venoms. | E Habermann | Science | 1972 | 4113805 | No |
2316 | 1243 | 1243.0 | 29.06 | 29.1 | Topoisomerase I inhibitors: camptothecins and beyond. | Yves Pommier | Nat Rev Cancer | 2006 | 16990856 | No |
2317 | 1243 | 1243.0 | 0.0 | 0.0 | Diversity in tropical rain forests and coral reefs. | J H Connell | Science | 1978 | 17840770 | Yes |
2318 | 1243 | 1243.0 | 41.44 | 41.4 | Chlorophyll fluorescence: a probe of photosynthesis in vivo. | Neil R Baker | Annu Rev Plant Biol | 2008 | 18444897 | No |
2319 | 3727 | 1242.3 | 136.89 | 45.6 | Global estimates of the prevalence of diabetes for 2010 and 2030. | J E Shaw, R A Sicree, P Z Zimmet | Diabetes Res Clin Pract | 2010 | 19896746 | Yes |
2320 | 1242 | 1242.0 | 0.0 | 0.0 | A modification of receptor theory. | R P Stephenson | Br J Pharmacol Chemother | 1956 | 13383117 | Yes |
2321 | 2482 | 1241.0 | 56.97 | 28.5 | Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. | D A Brown, J K Rose | Cell | 1992 | 1531449 | Yes |
2322 | 1241 | 1241.0 | 36.63 | 36.6 | Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. | P Willner | Psychopharmacology (Berl) | 1997 | 9452163 | No |
2323 | 2482 | 1241.0 | 67.01 | 33.5 | Cell signaling by receptor tyrosine kinases. | Mark A Lemmon, Joseph Schlessinger | Cell | 2010 | 20602996 | No |
2324 | 2480 | 1240.0 | 73.24 | 36.6 | Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. | J I Morgan, T Curran | Annu Rev Neurosci | 1991 | 1903243 | No |
2325 | 1240 | 1240.0 | 30.96 | 31.0 | The 'effective number of codons' used in a gene. | F Wright | Gene | 1990 | 2110097 | Yes |
2326 | 2480 | 1240.0 | 72.38 | 36.2 | The gut microbiota shapes intestinal immune responses during health and disease. | June L Round, Sarkis K Mazmanian | Nat Rev Immunol | 2009 | 19343057 | No |
2327 | 2479 | 1239.5 | 49.99 | 25.0 | Prediction of complete gene structures in human genomic DNA. | C Burge, S Karlin | J Mol Biol | 1997 | 9149143 | Yes |
2328 | 2479 | 1239.5 | 0.0 | 0.0 | The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. | B N Ames, D T Dubin | J Biol Chem | 1960 | 13793161 | Yes |
2329 | 2479 | 1239.5 | 186.45 | 93.2 | Natural Products as Sources of New Drugs from 1981 to 2014. | David J Newman, Gordon M Cragg | J Nat Prod | 2016 | 26852623 | No |
2330 | 2477 | 1238.5 | 56.66 | 28.3 | Escaping free-energy minima. | Alessandro Laio, Michele Parrinello | Proc Natl Acad Sci U S A | 2002 | 12271136 | Yes |
2331 | 1238 | 1238.0 | 37.58 | 37.6 | Circuitry and functional aspects of the insular lobe in primates including humans. | J R Augustine | Brain Res Brain Res Rev | 1996 | 8957561 | No |
2332 | 1238 | 1238.0 | 25.78 | 25.8 | Endocytosis and molecular sorting. | I Mellman | Annu Rev Cell Dev Biol | 1996 | 8970738 | No |
2333 | 2476 | 1238.0 | 64.56 | 32.3 | The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. | Clay B Holroyd, Michael G H Coles | Psychol Rev | 2002 | 12374324 | Yes |
2334 | 2475 | 1237.5 | 52.22 | 26.1 | The molecular biology of axon guidance. | M Tessier-Lavigne, C S Goodman | Science | 1996 | 8895455 | No |
2335 | 1237 | 1237.0 | 0.0 | 0.0 | Disconnexion syndromes in animals and man. I. | N Geschwind | Brain | 1965 | 5318481 | No |
2336 | 1237 | 1237.0 | 42.44 | 42.4 | How is the level of free arachidonic acid controlled in mammalian cells? | R F Irvine | Biochem J | 1982 | 6810878 | No |
2337 | 1237 | 1237.0 | 33.56 | 33.6 | Marine viruses--major players in the global ecosystem. | Curtis A Suttle | Nat Rev Microbiol | 2007 | 17853907 | No |
2338 | 1236 | 1236.0 | 0.0 | 0.0 | A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. | A M Olovnikov | J Theor Biol | 1973 | 4754905 | Yes |
2339 | 2472 | 1236.0 | 0.0 | 0.0 | Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. | G J Todaro, H Green | J Cell Biol | 1963 | 13985244 | Yes |
2340 | 1236 | 1236.0 | 29.56 | 29.6 | Refined structure of the nicotinic acetylcholine receptor at 4A resolution. | Nigel Unwin | J Mol Biol | 2005 | 15701510 | Yes |
2341 | 1236 | 1236.0 | 63.14 | 63.1 | Optical properties of biological tissues: a review. | Steven L Jacques | Phys Med Biol | 2013 | 23666068 | No |
2342 | 2470 | 1235.0 | 0.0 | 0.0 | Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. | A Fabiato, F Fabiato | J Physiol (Paris) | 1979 | 533865 | Yes |
2343 | 2470 | 1235.0 | 91.08 | 45.5 | The stunned myocardium: prolonged, postischemic ventricular dysfunction. | E Braunwald, R A Kloner | Circulation | 1982 | 6754130 | No |
2344 | 1235 | 1235.0 | 31.28 | 31.3 | Fast and robust fixed-point algorithms for independent component analysis. | A Hyvärinen | IEEE Trans Neural Netw | 1999 | 18252563 | Yes |
2345 | 1235 | 1235.0 | 33.59 | 33.6 | Reconciling the chemistry and biology of reactive oxygen species. | Christine C Winterbourn | Nat Chem Biol | 2008 | 18421291 | No |
2346 | 1235 | 1235.0 | 46.65 | 46.6 | Inflammation in atherosclerosis. | Peter Libby | Arterioscler Thromb Vasc Biol | 2012 | 22895665 | No |
2347 | 6171 | 1234.2 | 150.47 | 30.1 | Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. | T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L Coffman | J Immunol | 1986 | 2419430 | Yes |
2348 | 1234 | 1234.0 | 30.06 | 30.1 | Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? | Rui Wang | FASEB J | 2002 | 12409322 | Yes |
2349 | 1234 | 1234.0 | 0.0 | 0.0 | Sequential tests for the detection of linkage. | N E Morton | Am J Hum Genet | 1955 | 13258560 | Yes |
2350 | 2468 | 1234.0 | 74.87 | 37.4 | Epidemiology of invasive candidiasis: a persistent public health problem. | M A Pfaller, D J Diekema | Clin Microbiol Rev | 2007 | 17223626 | No |
2351 | 2466 | 1233.0 | 89.6 | 44.8 | Total energy intake: implications for epidemiologic analyses. | W Willett, M J Stampfer | Am J Epidemiol | 1986 | 3521261 | No |
2352 | 1233 | 1233.0 | 31.14 | 31.1 | Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. | J Deisenhofer | Biochemistry | 1981 | 7236608 | Yes |
2353 | 1233 | 1233.0 | 0.0 | 0.0 | The critical incident technique. | J C Flanagan | Psychol Bull | 1954 | 13177800 | Yes |
2354 | 2465 | 1232.5 | 78.08 | 39.0 | The benefits of being present: mindfulness and its role in psychological well-being. | Kirk Warren Brown, Richard M Ryan | J Pers Soc Psychol | 2003 | 12703651 | Yes |
2355 | 1232 | 1232.0 | 24.9 | 24.9 | STATs: signal transducers and activators of transcription. | J N Ihle | Cell | 1996 | 8608586 | No |
2356 | 1232 | 1232.0 | 40.81 | 40.8 | An application of prefrontal cortex function theory to cognitive aging. | R L West | Psychol Bull | 1996 | 8831298 | No |
2357 | 6156 | 1231.2 | 0.0 | 0.0 | Transection of the oesophagus for bleeding oesophageal varices. | R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R Williams | Br J Surg | 1973 | 4541913 | Yes |
2358 | 2462 | 1231.0 | 112.93 | 56.5 | Natural products as sources of new drugs over the 30 years from 1981 to 2010. | David J Newman, Gordon M Cragg | J Nat Prod | 2012 | 22316239 | No |
2359 | 1230 | 1230.0 | 35.57 | 35.6 | Stress and depression. | Constance Hammen | Annu Rev Clin Psychol | 2005 | 17716090 | No |
2360 | 2457 | 1228.5 | 62.62 | 31.3 | Interneurons of the hippocampus. | T F Freund, G Buzsáki | Hippocampus | 1996 | 8915675 | No |
2361 | 2457 | 1228.5 | 65.6 | 32.8 | The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. | Daniel J Drucker, Michael A Nauck | Lancet | 2006 | 17098089 | No |
2362 | 1228 | 1228.0 | 38.33 | 38.3 | Classification of chronic viral hepatitis: a need for reassessment. | P J Scheuer | J Hepatol | 1991 | 1808228 | No |
2363 | 1228 | 1228.0 | 0.0 | 0.0 | Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. | P Rakic | J Comp Neurol | 1971 | 4101340 | Yes |
2364 | 1228 | 1228.0 | 0.0 | 0.0 | A restriction point for control of normal animal cell proliferation. | A B Pardee | Proc Natl Acad Sci U S A | 1974 | 4524638 | Yes |
2365 | 2455 | 1227.5 | 47.73 | 23.9 | Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. | C Li, W H Wong | Proc Natl Acad Sci U S A | 2001 | 11134512 | Yes |
2366 | 2454 | 1227.0 | 62.05 | 31.0 | Pharmacology and functions of metabotropic glutamate receptors. | P J Conn, J P Pin | Annu Rev Pharmacol Toxicol | 1997 | 9131252 | No |
2367 | 1227 | 1227.0 | 22.91 | 22.9 | SUMO: a history of modification. | Ronald T Hay | Mol Cell | 2005 | 15808504 | No |
2368 | 2454 | 1227.0 | 64.93 | 32.5 | Powering the planet: chemical challenges in solar energy utilization. | Nathan S Lewis, Daniel G Nocera | Proc Natl Acad Sci U S A | 2006 | 17043226 | Yes |
2369 | 3680 | 1226.7 | 93.74 | 31.2 | Long non-coding RNAs: insights into functions. | Tim R Mercer, Marcel E Dinger, John S Mattick | Nat Rev Genet | 2009 | 19188922 | No |
2370 | 6132 | 1226.4 | 158.06 | 31.6 | Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. | Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory Collins | Lancet | 2002 | 12493255 | Yes |
2371 | 3678 | 1226.0 | 167.86 | 56.0 | In search of how people change. Applications to addictive behaviors. | J O Prochaska, C C DiClemente, J C Norcross | Am Psychol | 1992 | 1329589 | Yes |
2372 | 1226 | 1226.0 | 34.83 | 34.8 | Tumor angiogenesis. | J Folkman | Adv Cancer Res | 1985 | 2581424 | No |
2373 | 1226 | 1226.0 | 0.0 | 0.0 | The biologic clock: the mitochondria? | D Harman | J Am Geriatr Soc | 1972 | 5016631 | Yes |
2374 | 1226 | 1226.0 | 46.79 | 46.8 | The structure of beta-lactamases. | R P Ambler | Philos Trans R Soc Lond B Biol Sci | 1980 | 6109327 | Yes |
2375 | 1226 | 1226.0 | 21.83 | 21.8 | The economics of ribosome biosynthesis in yeast. | J R Warner | Trends Biochem Sci | 1999 | 10542411 | No |
2376 | 2451 | 1225.5 | 84.23 | 42.1 | Oxidative stress and diabetic complications. | Ferdinando Giacco, Michael Brownlee | Circ Res | 2010 | 21030723 | No |
2377 | 1225 | 1225.0 | 37.7 | 37.7 | Calcium channel modulation by neurotransmitters, enzymes and drugs. | H Reuter | Nature | 1983 | 6131381 | No |
2378 | 1225 | 1225.0 | 22.53 | 22.5 | Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. | H E Ruley | Nature | 1983 | 6308473 | Yes |
2379 | 1225 | 1225.0 | 29.03 | 29.0 | Oxyradicals and DNA damage. | L J Marnett | Carcinogenesis | 2000 | 10688856 | No |
2380 | 1225 | 1225.0 | 33.94 | 33.9 | Genetic consequences of climatic oscillations in the Quaternary. | G M Hewitt | Philos Trans R Soc Lond B Biol Sci | 2004 | 15101575 | No |
2381 | 1225 | 1225.0 | 41.54 | 41.5 | Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. | Chao-Jun Li | Acc Chem Res | 2009 | 19220064 | Yes |
2382 | 19597 | 1224.8 | 728.7 | 45.5 | Fiji: an open-source platform for biological-image analysis. | Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert Cardona | Nat Methods | 2012 | 22743772 | Yes |
2383 | 2449 | 1224.5 | 59.31 | 29.7 | Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. | Jane E Visvader, Geoffrey J Lindeman | Nat Rev Cancer | 2008 | 18784658 | No |
2384 | 3673 | 1224.3 | 121.74 | 40.6 | Simultaneous inference in general parametric models. | Torsten Hothorn, Frank Bretz, Peter Westfall | Biom J | 2008 | 18481363 | No |
2385 | 1224 | 1224.0 | 0.0 | 0.0 | On the psychophysical law. | S S Stevens | Psychol Rev | 1957 | 13441853 | Yes |
2386 | 2448 | 1224.0 | 70.05 | 35.0 | Molecular replacement with MOLREP. | Alexei Vagin, Alexei Teplyakov | Acta Crystallogr D Biol Crystallogr | 2010 | 20057045 | Yes |
2387 | 2447 | 1223.5 | 65.44 | 32.7 | A globally coherent fingerprint of climate change impacts across natural systems. | Camille Parmesan, Gary Yohe | Nature | 2003 | 12511946 | Yes |
2388 | 2446 | 1223.0 | 63.65 | 31.8 | Genetic dissection of complex traits. | E S Lander, N J Schork | Science | 1994 | 8091226 | No |
2389 | 3668 | 1222.7 | 87.19 | 29.1 | Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. | Christian W Tornøe, Caspar Christensen, Morten Meldal | J Org Chem | 2002 | 11975567 | Yes |
2390 | 1222 | 1222.0 | 43.09 | 43.1 | The theoretical bases of indirect calorimetry: a review. | E Ferrannini | Metabolism | 1988 | 3278194 | No |
2391 | 1222 | 1222.0 | 0.0 | 0.0 | Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. | P O Seglen | Exp Cell Res | 1973 | 4358115 | Yes |
2392 | 1222 | 1222.0 | 44.37 | 44.4 | Multimodal approach to control postoperative pathophysiology and rehabilitation. | H Kehlet | Br J Anaesth | 1997 | 9175983 | No |
2393 | 2444 | 1222.0 | 0.0 | 0.0 | Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. | H A Edmondson, P E Steiner | Cancer | 1954 | 13160935 | Yes |
2394 | 1221 | 1221.0 | 0.0 | 0.0 | Observations on the isolated phrenic nerve diaphragm preparation of the rat. | E Bulbring | Br J Pharmacol Chemother | 1946 | 20999334 | Yes |
2395 | 3662 | 1220.7 | 98.22 | 32.7 | Cognitive and emotional influences in anterior cingulate cortex. | Bush, Luu, Posner | Trends Cogn Sci | 2000 | 10827444 | Yes |
2396 | 3662 | 1220.7 | 113.36 | 37.8 | A rapid bootstrap algorithm for the RAxML Web servers. | Alexandros Stamatakis, Paul Hoover, Jacques Rougemont | Syst Biol | 2008 | 18853362 | Yes |
2397 | 2440 | 1220.0 | 0.0 | 0.0 | Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. | G K McMaster, G G Carmichael | Proc Natl Acad Sci U S A | 1977 | 73185 | Yes |
2398 | 1220 | 1220.0 | 60.08 | 60.1 | New norms of upper limb fat and muscle areas for assessment of nutritional status. | A R Frisancho | Am J Clin Nutr | 1981 | 6975564 | Yes |
2399 | 1219 | 1219.0 | 31.67 | 31.7 | Rapid evolution of a protein in vitro by DNA shuffling. | W P Stemmer | Nature | 1994 | 8047147 | Yes |
2400 | 2437 | 1218.5 | 61.46 | 30.7 | Molecular mechanisms of action of steroid/thyroid receptor superfamily members. | M J Tsai, B W O'Malley | Annu Rev Biochem | 1994 | 7979245 | No |
2401 | 1218 | 1218.0 | 24.62 | 24.6 | Cytokines induce the development of functionally heterogeneous T helper cell subsets. | A O'Garra | Immunity | 1998 | 9529145 | No |
2402 | 1218 | 1218.0 | 33.17 | 33.2 | The human orbitofrontal cortex: linking reward to hedonic experience. | Morten L Kringelbach | Nat Rev Neurosci | 2005 | 16136173 | No |
2403 | 4871 | 1217.8 | 217.34 | 54.3 | Bayesian phylogenetics with BEAUti and the BEAST 1.7. | Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew Rambaut | Mol Biol Evol | 2012 | 22367748 | Yes |
2404 | 2435 | 1217.5 | 51.97 | 26.0 | Regulated portals of entry into the cell. | Sean D Conner, Sandra L Schmid | Nature | 2003 | 12621426 | No |
2405 | 13389 | 1217.2 | 380.68 | 34.6 | The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. | Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J Roccella | JAMA | 2003 | 12748199 | No |
2406 | 2434 | 1217.0 | 68.19 | 34.1 | Nitric oxide synthases: roles, tolls, and controls. | C Nathan, Q W Xie | Cell | 1994 | 7522969 | No |
2407 | 1217 | 1217.0 | 27.93 | 27.9 | Gene finding in novel genomes. | Ian Korf | BMC Bioinformatics | 2004 | 15144565 | Yes |
2408 | 1216 | 1216.0 | 33.82 | 33.8 | Diagnosis of osteoporosis and assessment of fracture risk. | John A Kanis | Lancet | 2002 | 12057569 | No |
2409 | 1216 | 1216.0 | 0.0 | 0.0 | The anterior approach for removal of ruptured cervical disks. | R B Cloward | J Neurosurg | 1958 | 13599052 | Yes |
2410 | 2431 | 1215.5 | 0.0 | 0.0 | Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. | J M Tanner, R H Whitehouse | Arch Dis Child | 1976 | 952550 | Yes |
2411 | 2431 | 1215.5 | 77.12 | 38.6 | The cortical organization of speech processing. | Gregory Hickok, David Poeppel | Nat Rev Neurosci | 2007 | 17431404 | No |
2412 | 1215 | 1215.0 | 31.35 | 31.4 | The mitochondrial electron transport and oxidative phosphorylation system. | Y Hatefi | Annu Rev Biochem | 1985 | 2862839 | No |
2413 | 1215 | 1215.0 | 36.8 | 36.8 | Qinghaosu (artemisinin): an antimalarial drug from China. | D L Klayman | Science | 1985 | 3887571 | No |
2414 | 1215 | 1215.0 | 30.94 | 30.9 | Endothelial-leukocyte adhesion molecules. | M P Bevilacqua | Annu Rev Immunol | 1993 | 8476577 | No |
2415 | 1215 | 1215.0 | 28.01 | 28.0 | Physiological and molecular basis of thyroid hormone action. | P M Yen | Physiol Rev | 2001 | 11427693 | No |
2416 | 2430 | 1215.0 | 46.27 | 23.1 | Live or let die: the cell's response to p53. | Karen H Vousden, Xin Lu | Nat Rev Cancer | 2002 | 12154352 | No |
2417 | 1215 | 1215.0 | 35.32 | 35.3 | Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. | Arnold I Caplan | J Cell Physiol | 2007 | 17620285 | No |
2418 | 1215 | 1215.0 | 47.6 | 47.6 | Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. | T Florian Jaeger | J Mem Lang | 2008 | 19884961 | Yes |
2419 | 2429 | 1214.5 | 79.57 | 39.8 | Oxidative mechanisms in the toxicity of metal ions. | S J Stohs, D Bagchi | Free Radic Biol Med | 1995 | 7744317 | No |
2420 | 2429 | 1214.5 | 80.98 | 40.5 | Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. | Johan W S Vlaeyen, Steven J Linton | Pain | 2000 | 10781906 | No |
2421 | 1214 | 1214.0 | 35.49 | 35.5 | Peptide antibiotics and their role in innate immunity. | H G Boman | Annu Rev Immunol | 1995 | 7612236 | No |
2422 | 1214 | 1214.0 | 27.02 | 27.0 | Heterotrimeric G proteins: organizers of transmembrane signals. | E J Neer | Cell | 1995 | 7834744 | No |
2423 | 1214 | 1214.0 | 0.0 | 0.0 | A new readability yardstick. | R Flesch | J Appl Psychol | 1948 | 18867058 | Yes |
2424 | 2426 | 1213.0 | 0.0 | 0.0 | High resolution acrylamide gel electrophoresis of histones. | S Panyim, R Chalkley | Arch Biochem Biophys | 1969 | 5778650 | Yes |
2425 | 1213 | 1213.0 | 0.0 | 0.0 | Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. | W D Hamilton | Science | 1967 | 6021675 | Yes |
2426 | 1213 | 1213.0 | 28.91 | 28.9 | Mechanisms of foxp3+ T regulatory cell-mediated suppression. | Ethan M Shevach | Immunity | 2009 | 19464986 | No |
2427 | 3637 | 1212.3 | 130.91 | 43.6 | A new method for off-line removal of ocular artifact. | G Gratton, M G Coles, E Donchin | Electroencephalogr Clin Neurophysiol | 1983 | 6187540 | Yes |
2428 | 1212 | 1212.0 | 24.57 | 24.6 | Mechanisms of caspase activation and inhibition during apoptosis. | Yigong Shi | Mol Cell | 2002 | 11931755 | No |
2429 | 1212 | 1212.0 | 34.8 | 34.8 | Polycystic ovary syndrome. | David A Ehrmann | N Engl J Med | 2005 | 15788499 | No |
2430 | 2423 | 1211.5 | 89.05 | 44.5 | How useful is SBF in predicting in vivo bone bioactivity? | Tadashi Kokubo, Hiroaki Takadama | Biomaterials | 2006 | 16448693 | No |
2431 | 2423 | 1211.5 | 75.69 | 37.8 | CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. | Mattias Jakobsson, Noah A Rosenberg | Bioinformatics | 2007 | 17485429 | Yes |
2432 | 6056 | 1211.2 | 192.99 | 38.6 | Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. | J S Beckman, T W Beckman, J Chen, P A Marshall, B A Freeman | Proc Natl Acad Sci U S A | 1990 | 2154753 | Yes |
2433 | 2422 | 1211.0 | 74.68 | 37.3 | An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. | Sun Ho Kim, Jin Mo Chung | Pain | 1992 | 1333581 | Yes |
2434 | 1211 | 1211.0 | 30.85 | 30.9 | The blood-brain barrier: bottleneck in brain drug development. | William M Pardridge | NeuroRx | 2005 | 15717053 | No |
2435 | 3633 | 1211.0 | 89.32 | 29.8 | Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? | Witold Filipowicz, Suvendra N Bhattacharyya, Nahum Sonenberg | Nat Rev Genet | 2008 | 18197166 | No |
2436 | 4842 | 1210.5 | 143.43 | 35.9 | Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. | N Weidner, J P Semple, W R Welch, J Folkman | N Engl J Med | 1991 | 1701519 | Yes |
2437 | 1210 | 1210.0 | 53.45 | 53.5 | MorphoJ: an integrated software package for geometric morphometrics. | Christian Peter Klingenberg | Mol Ecol Resour | 2011 | 21429143 | Yes |
2438 | 1210 | 1210.0 | 55.41 | 55.4 | Selenium and human health. | Margaret P Rayman | Lancet | 2012 | 22381456 | No |
2439 | 3628 | 1209.3 | 111.05 | 37.0 | Oxidants, antioxidants, and the degenerative diseases of aging. | B N Ames, M K Shigenaga, T M Hagen | Proc Natl Acad Sci U S A | 1993 | 8367443 | No |
2440 | 2418 | 1209.0 | 39.73 | 19.9 | A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. | D Tautz, C Pfeifle | Chromosoma | 1989 | 2476281 | Yes |
2441 | 7252 | 1208.7 | 183.73 | 30.6 | GROMACS: fast, flexible, and free. | David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C Berendsen | J Comput Chem | 2005 | 16211538 | Yes |
2442 | 2417 | 1208.5 | 61.85 | 30.9 | The free radical theory of aging matures. | K B Beckman, B N Ames | Physiol Rev | 1998 | 9562038 | No |
2443 | 1208 | 1208.0 | 55.37 | 55.4 | Continuous improvement as an ideal in health care. | D M Berwick | N Engl J Med | 1989 | 2909878 | Yes |
2444 | 1208 | 1208.0 | 33.81 | 33.8 | Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. | F Hefti | J Neurosci | 1986 | 3746405 | Yes |
2445 | 1208 | 1208.0 | 26.22 | 26.2 | Antigen-presenting function of the macrophage. | E R Unanue | Annu Rev Immunol | 1984 | 6242349 | No |
2446 | 1208 | 1208.0 | 38.46 | 38.5 | Linkage map of Escherichia coli K-12, edition 7. | B J Bachmann | Microbiol Rev | 1983 | 6348505 | No |
2447 | 1208 | 1208.0 | 24.02 | 24.0 | microRNAs: tiny regulators with great potential. | V Ambros | Cell | 2001 | 11779458 | No |
2448 | 1208 | 1208.0 | 34.26 | 34.3 | The cancer stem cell: premises, promises and challenges. | Hans Clevers | Nat Med | 2011 | 21386835 | No |
2449 | 2416 | 1208.0 | 116.74 | 58.4 | A new initiative on precision medicine. | Francis S Collins, Harold Varmus | N Engl J Med | 2015 | 25635347 | Yes |
2450 | 8451 | 1207.3 | 353.04 | 50.4 | Development and validation of a geriatric depression screening scale: a preliminary report. | J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O Leirer | J Psychiatr Res | 1982 | 7183759 | Yes |
2451 | 2414 | 1207.0 | 0.0 | 0.0 | Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. | J E Sulston, H R Horvitz | Dev Biol | 1977 | 838129 | Yes |
2452 | 1207 | 1207.0 | 34.51 | 34.5 | Emotion regulation: affective, cognitive, and social consequences. | James J Gross | Psychophysiology | 2002 | 12212647 | No |
2453 | 2414 | 1207.0 | 66.48 | 33.2 | ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. | Markus Wiederstein, Manfred J Sippl | Nucleic Acids Res | 2007 | 17517781 | Yes |
2454 | 1207 | 1207.0 | 35.36 | 35.4 | Atopic dermatitis. | Thomas Bieber | N Engl J Med | 2008 | 18385500 | Yes |
2455 | 2414 | 1207.0 | 84.29 | 42.1 | Oncology meets immunology: the cancer-immunity cycle. | Daniel S Chen, Ira Mellman | Immunity | 2013 | 23890059 | No |
2456 | 2413 | 1206.5 | 68.76 | 34.4 | The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. | W L Jorgensen, J Tirado-Rives | J Am Chem Soc | 1988 | 27557051 | Yes |
2457 | 2412 | 1206.0 | 44.07 | 22.0 | The DNA damage response: putting checkpoints in perspective. | B B Zhou, S J Elledge | Nature | 2000 | 11100718 | No |
2458 | 2412 | 1206.0 | 65.39 | 32.7 | Therapeutic potential of resveratrol: the in vivo evidence. | Joseph A Baur, David A Sinclair | Nat Rev Drug Discov | 2006 | 16732220 | No |
2459 | 7231 | 1205.2 | 189.47 | 31.6 | A default mode of brain function. | M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L Shulman | Proc Natl Acad Sci U S A | 2001 | 11209064 | Yes |
2460 | 1205 | 1205.0 | 36.32 | 36.3 | Invasive aspergillosis. | D W Denning | Clin Infect Dis | 1998 | 9564455 | No |
2461 | 2410 | 1205.0 | 68.74 | 34.4 | What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? | K C Berridge, T E Robinson | Brain Res Brain Res Rev | 1998 | 9858756 | No |
2462 | 1205 | 1205.0 | 0.0 | 0.0 | Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. | J M Van Rossum | Arch Int Pharmacodyn Ther | 1963 | 13996119 | Yes |
2463 | 2410 | 1205.0 | 0.0 | 0.0 | The Aggregation Of Blood Platelets. | G V Born, M J Cross | J Physiol | 1963 | 14056485 | Yes |
2464 | 2409 | 1204.5 | 74.56 | 37.3 | Mediation in experimental and nonexperimental studies: new procedures and recommendations. | Patrick E Shrout, Niall Bolger | Psychol Methods | 2002 | 12530702 | Yes |
2465 | 1204 | 1204.0 | 29.84 | 29.8 | Bcl-2 initiates a new category of oncogenes: regulators of cell death. | S J Korsmeyer | Blood | 1992 | 1498330 | No |
2466 | 2408 | 1204.0 | 47.19 | 23.6 | CpG islands in vertebrate genomes. | M Gardiner-Garden, M Frommer | J Mol Biol | 1987 | 3656447 | Yes |
2467 | 1204 | 1204.0 | 26.24 | 26.2 | Dendritic cells: unique leukocyte populations which control the primary immune response. | D N Hart | Blood | 1997 | 9345009 | No |
2468 | 1204 | 1204.0 | 27.91 | 27.9 | Diarylethenes for Memories and Switches. | Masahiro Irie | Chem Rev | 2000 | 11777416 | Yes |
2469 | 2407 | 1203.5 | 54.43 | 27.2 | The pathophysiology of mitochondrial cell death. | Douglas R Green, Guido Kroemer | Science | 2004 | 15286356 | No |
2470 | 2407 | 1203.5 | 51.2 | 25.6 | A general framework for weighted gene co-expression network analysis. | Bin Zhang, Steve Horvath | Stat Appl Genet Mol Biol | 2005 | 16646834 | Yes |
2471 | 2406 | 1203.0 | 75.97 | 38.0 | Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. | J E Hixson, D T Vernier | J Lipid Res | 1990 | 2341813 | Yes |
2472 | 1203 | 1203.0 | 25.41 | 25.4 | MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. | R N Germain | Cell | 1994 | 8293464 | No |
2473 | 13232 | 1202.9 | 331.14 | 30.1 | New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. | P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G Gwyther | J Natl Cancer Inst | 2000 | 10655437 | No |
2474 | 1202 | 1202.0 | 48.93 | 48.9 | An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. | J Kabat-Zinn | Gen Hosp Psychiatry | 1982 | 7042457 | Yes |
2475 | 2404 | 1202.0 | 45.46 | 22.7 | DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. | Christopher J Bakkenist, Michael B Kastan | Nature | 2003 | 12556884 | Yes |
2476 | 4806 | 1201.5 | 113.26 | 28.3 | Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. | Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J Thun | N Engl J Med | 2003 | 12711737 | Yes |
2477 | 2403 | 1201.5 | 69.71 | 34.9 | Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. | Robert E W Hancock, Hans-Georg Sahl | Nat Biotechnol | 2006 | 17160061 | No |
2478 | 2402 | 1201.0 | 62.25 | 31.1 | Neuronal plasticity: increasing the gain in pain. | C J Woolf, M W Salter | Science | 2000 | 10846153 | No |
2479 | 1201 | 1201.0 | 27.27 | 27.3 | The stem-cell niche as an entity of action. | David T Scadden | Nature | 2006 | 16810242 | No |
2480 | 3601 | 1200.3 | 63.78 | 21.3 | A system for stable expression of short interfering RNAs in mammalian cells. | Thijn R Brummelkamp, René Bernards, Reuven Agami | Science | 2002 | 11910072 | Yes |
2481 | 1200 | 1200.0 | 57.12 | 57.1 | Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement. | Virginia A Moyer | Ann Intern Med | 2014 | 24378917 | No |
2482 | 2399 | 1199.5 | 0.0 | 0.0 | Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. | J Altman, G D Das | J Comp Neurol | 1965 | 5861717 | Yes |
2483 | 1199 | 1199.0 | 32.48 | 32.5 | Low density lipoprotein oxidation and its pathobiological significance. | D Steinberg | J Biol Chem | 1997 | 9261091 | No |
2484 | 1198 | 1198.0 | 28.52 | 28.5 | Growth factors and cancer. | S A Aaronson | Science | 1991 | 1659742 | No |
2485 | 2396 | 1198.0 | 75.38 | 37.7 | Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. | D Filmer, L H Pritchett | Demography | 2001 | 11227840 | Yes |
2486 | 7187 | 1197.8 | 182.7 | 30.4 | Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. | Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O Lötvall | Nat Cell Biol | 2007 | 17486113 | Yes |
2487 | 2393 | 1196.5 | 47.84 | 23.9 | Checkpoints: controls that ensure the order of cell cycle events. | L H Hartwell, T A Weinert | Science | 1989 | 2683079 | No |
2488 | 1196 | 1196.0 | 27.35 | 27.4 | Hybridization of denatured RNA transferred or dotted nitrocellulose paper. | P S Thomas | Methods Enzymol | 1983 | 6194404 | Yes |
2489 | 1196 | 1196.0 | 29.34 | 29.3 | Reactive oxygen radicals in signaling and damage in the ischemic brain. | P H Chan | J Cereb Blood Flow Metab | 2001 | 11149664 | No |
2490 | 9565 | 1195.6 | 249.19 | 31.1 | Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. | N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M Joliot | Neuroimage | 2002 | 11771995 | Yes |
2491 | 1195 | 1195.0 | 66.71 | 66.7 | Psychosocial resilience and protective mechanisms. | Michael Rutter | Am J Orthopsychiatry | 1987 | 3303954 | No |
2492 | 1195 | 1195.0 | 48.51 | 48.5 | Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. | E H Beachey | J Infect Dis | 1981 | 7014727 | No |
2493 | 1195 | 1195.0 | 29.54 | 29.5 | Somatostatin and its receptor family. | Y C Patel | Front Neuroendocrinol | 1999 | 10433861 | No |
2494 | 1195 | 1195.0 | 0.0 | 0.0 | The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. | G A Rose | Bull World Health Organ | 1962 | 13974778 | Yes |
2495 | 1194 | 1194.0 | 59.24 | 59.2 | ROC methodology in radiologic imaging. | C E Metz | Invest Radiol | 1986 | 3095258 | No |
2496 | 1194 | 1194.0 | 33.93 | 33.9 | Diversity of group types, regulation, and function of phospholipase A2. | E A Dennis | J Biol Chem | 1994 | 8175726 | No |
2497 | 1194 | 1194.0 | 28.84 | 28.8 | Oxidative stress in neurodegeneration: cause or consequence? | Julie K Andersen | Nat Med | 2004 | 15298006 | No |
2498 | 2387 | 1193.5 | 0.0 | 0.0 | Surgical risk as related to time of intervention in the repair of intracranial aneurysms. | W E Hunt, R M Hess | J Neurosurg | 1968 | 5635959 | Yes |
2499 | 2387 | 1193.5 | 49.25 | 24.6 | Gene silencing in cancer in association with promoter hypermethylation. | James G Herman, Stephen B Baylin | N Engl J Med | 2003 | 14627790 | No |
2500 | 1193 | 1193.0 | 28.39 | 28.4 | The Unified Medical Language System (UMLS): integrating biomedical terminology. | Olivier Bodenreider | Nucleic Acids Res | 2004 | 14681409 | Yes |
2501 | 1193 | 1193.0 | 33.25 | 33.2 | Microbial influences in inflammatory bowel diseases. | R Balfour Sartor | Gastroenterology | 2008 | 18242222 | No |
2502 | 1192 | 1192.0 | 54.93 | 54.9 | Derivation and validation of a short-form oral health impact profile. | G D Slade | Community Dent Oral Epidemiol | 1997 | 9332805 | Yes |
2503 | 1192 | 1192.0 | 38.42 | 38.4 | Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? | Thomas Grobner | Nephrol Dial Transplant | 2006 | 16431890 | Yes |
2504 | 2383 | 1191.5 | 61.12 | 30.6 | Rising incidence of hepatocellular carcinoma in the United States. | H B El-Serag, A C Mason | N Engl J Med | 1999 | 10072408 | Yes |
2505 | 1191 | 1191.0 | 53.64 | 53.6 | Human agency in social cognitive theory. | A Bandura | Am Psychol | 1989 | 2782727 | Yes |
2506 | 1191 | 1191.0 | 29.78 | 29.8 | Hereditary cancer, oncogenes, and antioncogenes. | A G Knudson | Cancer Res | 1985 | 2983882 | Yes |
2507 | 1191 | 1191.0 | 29.02 | 29.0 | The path to ubiquitous and low-cost organic electronic appliances on plastic. | Stephen R Forrest | Nature | 2004 | 15118718 | Yes |
2508 | 1190 | 1190.0 | 0.0 | 0.0 | Campylobacter enteritis: a "new" disease. | M B Skirrow | Br Med J | 1977 | 871765 | Yes |
2509 | 1190 | 1190.0 | 0.0 | 0.0 | Assay of intestinal disaccharidases. | A Dahlqvist | Anal Biochem | 1968 | 5636962 | Yes |
2510 | 1190 | 1190.0 | 0.0 | 0.0 | Studies on phosphatidylcholine vesicles. Formation and physical characteristics. | C Huang | Biochemistry | 1969 | 5777332 | Yes |
2511 | 2380 | 1190.0 | 63.72 | 31.9 | Nanostructures in biodiagnostics. | Nathaniel L Rosi, Chad A Mirkin | Chem Rev | 2005 | 15826019 | No |
2512 | 2380 | 1190.0 | 64.47 | 32.2 | Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. | S Schulman, C Kearon | J Thromb Haemost | 2005 | 15842354 | Yes |
2513 | 2378 | 1189.0 | 64.59 | 32.3 | Leukocyte-endothelial adhesion molecules. | T M Carlos, J M Harlan | Blood | 1994 | 7522621 | No |
2514 | 1189 | 1189.0 | 45.55 | 45.5 | Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. | S H Safe | Crit Rev Toxicol | 1994 | 8037844 | No |
2515 | 1189 | 1189.0 | 26.14 | 26.1 | The finer things in X-ray diffraction data collection. | J W Pflugrath | Acta Crystallogr D Biol Crystallogr | 1999 | 10531521 | Yes |
2516 | 2377 | 1188.5 | 46.08 | 23.0 | The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. | T Maehama, J E Dixon | J Biol Chem | 1998 | 9593664 | Yes |
2517 | 3564 | 1188.0 | 124.46 | 41.5 | Factor structure of the Barratt impulsiveness scale. | J H Patton, M S Stanford, E S Barratt | J Clin Psychol | 1995 | 8778124 | Yes |
2518 | 1188 | 1188.0 | 26.81 | 26.8 | Prediction of protein cellular attributes using pseudo-amino acid composition. | K C Chou | Proteins | 2001 | 11288174 | Yes |
2519 | 3564 | 1188.0 | 88.98 | 29.7 | Thresholding of statistical maps in functional neuroimaging using the false discovery rate. | Christopher R Genovese, Nicole A Lazar, Thomas Nichols | Neuroimage | 2002 | 11906227 | Yes |
2520 | 3563 | 1187.7 | 86.31 | 28.8 | Dystrophin: the protein product of the Duchenne muscular dystrophy locus. | E P Hoffman, R H Brown, L M Kunkel | Cell | 1987 | 3319190 | Yes |
2521 | 2375 | 1187.5 | 0.0 | 0.0 | Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. | J D Peuler, G A Johnson | Life Sci | 1977 | 904439 | Yes |
2522 | 1187 | 1187.0 | 30.84 | 30.8 | Surrogate endpoints in clinical trials: definition and operational criteria. | R L Prentice | Stat Med | 1989 | 2727467 | Yes |
2523 | 1187 | 1187.0 | 0.0 | 0.0 | The cytoarchitectonic organization of the spinal cord in the cat. | B Rexed | J Comp Neurol | 1952 | 14946260 | Yes |
2524 | 1187 | 1187.0 | 23.44 | 23.4 | Mobile elements: drivers of genome evolution. | Haig H Kazazian | Science | 2004 | 15016989 | No |
2525 | 1187 | 1187.0 | 69.9 | 69.9 | The brain's default mode network. | Marcus E Raichle | Annu Rev Neurosci | 2015 | 25938726 | No |
2526 | 1186 | 1186.0 | 43.37 | 43.4 | Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. | R M Post | Am J Psychiatry | 1992 | 1353322 | No |
2527 | 3557 | 1185.7 | 95.62 | 31.9 | Membrane lipids: where they are and how they behave. | Gerrit van Meer, Dennis R Voelker, Gerald W Feigenson | Nat Rev Mol Cell Biol | 2008 | 18216768 | No |
2528 | 2371 | 1185.5 | 54.95 | 27.5 | Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. | T Hunter, B M Sefton | Proc Natl Acad Sci U S A | 1980 | 6246487 | Yes |
2529 | 3554 | 1184.7 | 91.12 | 30.4 | Functional porous coordination polymers. | Susumu Kitagawa, Ryo Kitaura, Shin-ichiro Noro | Angew Chem Int Ed Engl | 2004 | 15114565 | Yes |
2530 | 1184 | 1184.0 | 55.73 | 55.7 | A cognitive approach to panic. | D M Clark | Behav Res Ther | 1986 | 3741311 | Yes |
2531 | 1184 | 1184.0 | 0.0 | 0.0 | Displaced proximal humeral fractures. I. Classification and evaluation. | C S Neer | J Bone Joint Surg Am | 1970 | 5455339 | Yes |
2532 | 1184 | 1184.0 | 25.28 | 25.3 | Caspase structure, proteolytic substrates, and function during apoptotic cell death. | D W Nicholson | Cell Death Differ | 1999 | 10578171 | No |
2533 | 1184 | 1184.0 | 36.74 | 36.7 | Depression in late life: review and commentary. | Dan G Blazer | J Gerontol A Biol Sci Med Sci | 2003 | 12634292 | No |
2534 | 1183 | 1183.0 | 28.76 | 28.8 | Intracellular protein topogenesis. | G Blobel | Proc Natl Acad Sci U S A | 1980 | 6929499 | Yes |
2535 | 1183 | 1183.0 | 21.3 | 21.3 | Cancer susceptibility and the functions of BRCA1 and BRCA2. | Ashok R Venkitaraman | Cell | 2002 | 11832208 | No |
2536 | 1183 | 1183.0 | 0.0 | 0.0 | The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. | W G Duncombe | Clin Chim Acta | 1964 | 14122498 | Yes |
2537 | 2366 | 1183.0 | 80.38 | 40.2 | Quality control and preprocessing of metagenomic datasets. | Robert Schmieder, Robert Edwards | Bioinformatics | 2011 | 21278185 | Yes |
2538 | 3546 | 1182.0 | 92.92 | 31.0 | Atomic force microscope. | Binnig, Quate, Gerber | Phys Rev Lett | 1986 | 10033323 | Yes |
2539 | 1182 | 1182.0 | 29.87 | 29.9 | The neuropathology of schizophrenia. A critical review of the data and their interpretation. | P J Harrison | Brain | 1999 | 10219775 | No |
2540 | 1182 | 1182.0 | 27.8 | 27.8 | Transcriptional control of adipocyte formation. | Stephen R Farmer | Cell Metab | 2006 | 17011499 | No |
2541 | 1182 | 1182.0 | 28.24 | 28.2 | DNA damage, aging, and cancer. | Jan H J Hoeijmakers | N Engl J Med | 2009 | 19812404 | No |
2542 | 1181 | 1181.0 | 38.1 | 38.1 | The pathogenesis of sepsis. | R C Bone | Ann Intern Med | 1991 | 1872494 | No |
2543 | 1181 | 1181.0 | 29.51 | 29.5 | Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. | P Kuzmic | Anal Biochem | 1996 | 8660575 | Yes |
2544 | 3542 | 1180.7 | 82.64 | 27.5 | OrthoMCL: identification of ortholog groups for eukaryotic genomes. | Li Li, Christian J Stoeckert, David S Roos | Genome Res | 2003 | 12952885 | Yes |
2545 | 2361 | 1180.5 | 112.04 | 56.0 | ROS function in redox signaling and oxidative stress. | Michael Schieber, Navdeep S Chandel | Curr Biol | 2014 | 24845678 | No |
2546 | 4717 | 1179.2 | 100.17 | 25.0 | Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. | D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini | Science | 2005 | 15718470 | Yes |
2547 | 2358 | 1179.0 | 123.11 | 61.6 | A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. | M Roland, R Morris | Spine (Phila Pa 1976) | 1983 | 6222486 | Yes |
2548 | 1179 | 1179.0 | 37.84 | 37.8 | Antioxidants in human health and disease. | B Halliwell | Annu Rev Nutr | 1996 | 8839918 | No |
2549 | 1179 | 1179.0 | 31.37 | 31.4 | Drug delivery and targeting. | R Langer | Nature | 1998 | 9579855 | No |
2550 | 2358 | 1179.0 | 56.71 | 28.4 | Peroxisome proliferator-activated receptors: nuclear control of metabolism. | B Desvergne, W Wahli | Endocr Rev | 1999 | 10529898 | No |
2551 | 1179 | 1179.0 | 32.26 | 32.3 | Plasmonics: merging photonics and electronics at nanoscale dimensions. | Ekmel Ozbay | Science | 2006 | 16410515 | Yes |
2552 | 3534 | 1178.0 | 86.43 | 28.8 | Global and societal implications of the diabetes epidemic. | P Zimmet, K G Alberti, J Shaw | Nature | 2001 | 11742409 | No |
2553 | 2356 | 1178.0 | 62.12 | 31.1 | Regulation mechanisms and signaling pathways of autophagy. | Congcong He, Daniel J Klionsky | Annu Rev Genet | 2009 | 19653858 | No |
2554 | 3531 | 1177.0 | 106.75 | 35.6 | The functional anatomy of basal ganglia disorders. | R L Albin, A B Young, J B Penney | Trends Neurosci | 1989 | 2479133 | No |
2555 | 1177 | 1177.0 | 0.0 | 0.0 | An approximate distribution of estimates of variance components. | F E Satterthwaite | Biometrics | 1946 | 20287815 | Yes |
2556 | 4706 | 1176.5 | 110.33 | 27.6 | A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. | Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry Sharpless | Angew Chem Int Ed Engl | 2002 | 12203546 | Yes |
2557 | 16470 | 1176.4 | 364.11 | 26.0 | Crystallography & NMR system: A new software suite for macromolecular structure determination. | A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L Warren | Acta Crystallogr D Biol Crystallogr | 1998 | 9757107 | Yes |
2558 | 1176 | 1176.0 | 0.0 | 0.0 | Mutation selection and the natural history of cancer. | J Cairns | Nature | 1975 | 1143315 | Yes |
2559 | 1176 | 1176.0 | 44.78 | 44.8 | A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. | S T Tiffany | Psychol Rev | 1990 | 2186423 | No |
2560 | 1176 | 1176.0 | 24.6 | 24.6 | Morphogenetic roles of classic cadherins. | M Takeichi | Curr Opin Cell Biol | 1995 | 8573335 | No |
2561 | 1176 | 1176.0 | 54.67 | 54.7 | Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. | P de Leva | J Biomech | 1996 | 8872282 | Yes |
2562 | 1176 | 1176.0 | 26.72 | 26.7 | S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. | R Donato | Int J Biochem Cell Biol | 2001 | 11390274 | No |
2563 | 1176 | 1176.0 | 21.72 | 21.7 | The molecular motor toolbox for intracellular transport. | Ronald D Vale | Cell | 2003 | 12600311 | No |
2564 | 1175 | 1175.0 | 22.13 | 22.1 | Kinesin and dynein superfamily proteins and the mechanism of organelle transport. | N Hirokawa | Science | 1998 | 9438838 | No |
2565 | 3524 | 1174.7 | 74.07 | 24.7 | Large-scale analysis of the yeast proteome by multidimensional protein identification technology. | M P Washburn, D Wolters, J R Yates | Nat Biotechnol | 2001 | 11231557 | Yes |
2566 | 1174 | 1174.0 | 0.0 | 0.0 | Measurement of feelings using visual analogue scales. | R C Aitken | Proc R Soc Med | 1969 | 4899510 | No |
2567 | 1174 | 1174.0 | 39.69 | 39.7 | Interleukin-1 and the pathogenesis of the acute-phase response. | C A Dinarello | N Engl J Med | 1984 | 6208485 | No |
2568 | 1174 | 1174.0 | 26.95 | 26.9 | Nuclear factor-kappaB: the enemy within. | Bharat B Aggarwal | Cancer Cell | 2004 | 15380510 | No |
2569 | 1174 | 1174.0 | 0.0 | 0.0 | Histological demonstration of mucin after periodic acid. | J F A McMANUS | Nature | 1946 | 20995486 | Yes |
2570 | 2347 | 1173.5 | 66.04 | 33.0 | Antibiotic resistance of bacteria in biofilms. | P S Stewart, J W Costerton | Lancet | 2001 | 11463434 | No |
2571 | 1173 | 1173.0 | 36.76 | 36.8 | Biosynthesis and metabolism of endothelium-derived nitric oxide. | L J Ignarro | Annu Rev Pharmacol Toxicol | 1990 | 2188578 | No |
2572 | 3519 | 1173.0 | 102.36 | 34.1 | Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. | H King, R E Aubert, W H Herman | Diabetes Care | 1998 | 9727886 | Yes |
2573 | 1173 | 1173.0 | 33.53 | 33.5 | The sympathetic control of blood pressure. | Patrice G Guyenet | Nat Rev Neurosci | 2006 | 16760914 | No |
2574 | 1172 | 1172.0 | 0.0 | 0.0 | A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. | J B Brown | Biochem J | 1955 | 14389222 | Yes |
2575 | 2344 | 1172.0 | 93.94 | 47.0 | Neutrophil recruitment and function in health and inflammation. | Elzbieta Kolaczkowska, Paul Kubes | Nat Rev Immunol | 2013 | 23435331 | No |
2576 | 2343 | 1171.5 | 64.14 | 32.1 | Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. | M A Pfeffer, E Braunwald | Circulation | 1990 | 2138525 | No |
2577 | 1171 | 1171.0 | 36.23 | 36.2 | The mysteries of lipoprotein(a). | G Utermann | Science | 1989 | 2530631 | No |
2578 | 1171 | 1171.0 | 40.77 | 40.8 | The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. | N M Kaplan | Arch Intern Med | 1989 | 2662932 | No |
2579 | 1171 | 1171.0 | 22.68 | 22.7 | Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. | Ricky W Johnstone | Nat Rev Drug Discov | 2002 | 12120280 | No |
2580 | 2342 | 1171.0 | 50.44 | 25.2 | ERBB receptors and cancer: the complexity of targeted inhibitors. | Nancy E Hynes, Heidi A Lane | Nat Rev Cancer | 2005 | 15864276 | No |
2581 | 3511 | 1170.3 | 86.63 | 28.9 | Functional diversity of helper T lymphocytes. | A K Abbas, K M Murphy, A Sher | Nature | 1996 | 8893001 | No |
2582 | 1170 | 1170.0 | 0.0 | 0.0 | Nontuberculous mycobacteria and associated diseases. | E Wolinsky | Am Rev Respir Dis | 1979 | 369415 | No |
2583 | 1170 | 1170.0 | 52.82 | 52.8 | Presynaptic regulation of the release of catecholamines. | S Z Langer | Pharmacol Rev | 1980 | 6267618 | Yes |
2584 | 1170 | 1170.0 | 34.79 | 34.8 | Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. | W Sieghart | Pharmacol Rev | 1995 | 7568326 | No |
2585 | 2340 | 1170.0 | 97.29 | 48.6 | Van der Waals heterostructures. | A K Geim, I V Grigorieva | Nature | 2013 | 23887427 | Yes |
2586 | 2339 | 1169.5 | 62.84 | 31.4 | Myocardial reperfusion injury. | Derek M Yellon, Derek J Hausenloy | N Engl J Med | 2007 | 17855673 | No |
2587 | 2339 | 1169.5 | 59.39 | 29.7 | Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. | Kornelia Polyak, Robert A Weinberg | Nat Rev Cancer | 2009 | 19262571 | No |
2588 | 1169 | 1169.0 | 26.09 | 26.1 | The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. | S J Collins | Blood | 1987 | 3311197 | No |
2589 | 1169 | 1169.0 | 53.76 | 53.8 | Biomaterial-centered infection: microbial adhesion versus tissue integration. | A G Gristina | Science | 1987 | 3629258 | Yes |
2590 | 2338 | 1169.0 | 64.0 | 32.0 | A review of central 5-HT receptors and their function. | N M Barnes, T Sharp | Neuropharmacology | 1999 | 10462127 | No |
2591 | 1169 | 1169.0 | 26.9 | 26.9 | Long-term potentiation and memory. | M A Lynch | Physiol Rev | 2004 | 14715912 | No |
2592 | 10517 | 1168.6 | 357.57 | 39.7 | A novel potent vasoconstrictor peptide produced by vascular endothelial cells. | M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T Masaki | Nature | 1988 | 2451132 | Yes |
2593 | 2335 | 1167.5 | 0.0 | 0.0 | The low-density lipoprotein pathway and its relation to atherosclerosis. | J L Goldstein, M S Brown | Annu Rev Biochem | 1977 | 197883 | No |
2594 | 2335 | 1167.5 | 95.39 | 47.7 | Rapid procedure for detection and isolation of large and small plasmids. | C I Kado, S T Liu | J Bacteriol | 1981 | 7009583 | Yes |
2595 | 3502 | 1167.3 | 89.94 | 30.0 | LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. | A C Wallace, R A Laskowski, J M Thornton | Protein Eng | 1995 | 7630882 | Yes |
2596 | 3502 | 1167.3 | 97.72 | 32.6 | Molecular characterization of a peripheral receptor for cannabinoids. | S Munro, K L Thomas, M Abu-Shaar | Nature | 1993 | 7689702 | Yes |
2597 | 3502 | 1167.3 | 92.34 | 30.8 | Wnt/beta-catenin signaling: components, mechanisms, and diseases. | Bryan T MacDonald, Keiko Tamai, Xi He | Dev Cell | 2009 | 19619488 | No |
2598 | 5836 | 1167.2 | 112.92 | 22.6 | Crystal structure of the nucleosome core particle at 2.8 A resolution. | K Luger, A W Mäder, R K Richmond, D F Sargent, T J Richmond | Nature | 1997 | 9305837 | Yes |
2599 | 1167 | 1167.0 | 44.35 | 44.4 | Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. | S Katz | J Am Geriatr Soc | 1983 | 6418786 | No |
2600 | 3501 | 1167.0 | 75.86 | 25.3 | Calcium signalling: dynamics, homeostasis and remodelling. | Michael J Berridge, Martin D Bootman, H Llewelyn Roderick | Nat Rev Mol Cell Biol | 2003 | 12838335 | No |
2601 | 1167 | 1167.0 | 38.6 | 38.6 | The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. | Artemis P Simopoulos | Exp Biol Med (Maywood) | 2008 | 18408140 | No |
2602 | 2333 | 1166.5 | 50.42 | 25.2 | Tumorigenesis and the angiogenic switch. | Gabriele Bergers, Laura E Benjamin | Nat Rev Cancer | 2003 | 12778130 | No |
2603 | 1166 | 1166.0 | 49.44 | 49.4 | Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). | S Safe | Crit Rev Toxicol | 1990 | 2124811 | No |
2604 | 1166 | 1166.0 | 59.1 | 59.1 | The clinical application of the biopsychosocial model. | G L Engel | Am J Psychiatry | 1980 | 7369396 | Yes |
2605 | 1166 | 1166.0 | 41.35 | 41.4 | Inhibition and facilitation of nucleic acid amplification. | I G Wilson | Appl Environ Microbiol | 1997 | 9327537 | No |
2606 | 1166 | 1166.0 | 34.19 | 34.2 | Varieties of impulsivity. | J L Evenden | Psychopharmacology (Berl) | 1999 | 10550486 | No |
2607 | 1166 | 1166.0 | 0.0 | 0.0 | A sensitive method for the assay of 5-hydroxytryptamine. | J R Vane | Br J Pharmacol Chemother | 1957 | 13460242 | Yes |
2608 | 2332 | 1166.0 | 0.0 | 0.0 | Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. | R W Butcher, E W Sutherland | J Biol Chem | 1962 | 13875173 | Yes |
2609 | 3496 | 1165.3 | 76.3 | 25.4 | Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). | Michael J Rust, Mark Bates, Xiaowei Zhuang | Nat Methods | 2006 | 16896339 | Yes |
2610 | 1165 | 1165.0 | 29.35 | 29.4 | Huntington's disease. | Francis O Walker | Lancet | 2007 | 17240289 | No |
2611 | 3494 | 1164.7 | 0.0 | 0.0 | Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. | A DeLean, P J Munson, D Rodbard | Am J Physiol | 1978 | 686171 | Yes |
2612 | 5823 | 1164.6 | 192.07 | 38.4 | Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. | D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L Witztum | N Engl J Med | 1989 | 2648148 | No |
2613 | 2328 | 1164.0 | 91.13 | 45.6 | Malondialdehyde determination as index of lipid peroxidation. | H H Draper, M Hadley | Methods Enzymol | 1990 | 2233309 | Yes |
2614 | 2327 | 1163.5 | 61.22 | 30.6 | Microglia: active sensor and versatile effector cells in the normal and pathologic brain. | Uwe-Karsten Hanisch, Helmut Kettenmann | Nat Neurosci | 2007 | 17965659 | No |
2615 | 1163 | 1163.0 | 61.56 | 61.6 | Rating scales to assess depression in school-aged children. | M Kovacs | Acta Paedopsychiatr | 1981 | 7025571 | Yes |
2616 | 1163 | 1163.0 | 19.68 | 19.7 | Themes and variations on ubiquitylation. | A M Weissman | Nat Rev Mol Cell Biol | 2001 | 11265246 | No |
2617 | 3488 | 1162.7 | 0.0 | 0.0 | Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. | A L Shapiro, E Viñuela, J V Maizel | Biochem Biophys Res Commun | 1967 | 4861258 | Yes |
2618 | 1162 | 1162.0 | 27.64 | 27.6 | Liver fibrosis -- from bench to bedside. | Scott L Friedman | J Hepatol | 2003 | 12591185 | No |
2619 | 6969 | 1161.5 | 136.25 | 22.7 | Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. | S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T Tuschl | Nature | 2001 | 11373684 | Yes |
2620 | 1161 | 1161.0 | 31.36 | 31.4 | The lipocalin protein family: structure and function. | D R Flower | Biochem J | 1996 | 8761444 | No |
2621 | 3483 | 1161.0 | 72.64 | 24.2 | Cellular survival: a play in three Akts. | S R Datta, A Brunet, M E Greenberg | Genes Dev | 1999 | 10579998 | No |
2622 | 2321 | 1160.5 | 45.72 | 22.9 | Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. | C W Greider, E H Blackburn | Cell | 1985 | 3907856 | Yes |
2623 | 2321 | 1160.5 | 47.84 | 23.9 | Molecular chaperones in the cytosol: from nascent chain to folded protein. | F Ulrich Hartl, Manajit Hayer-Hartl | Science | 2002 | 11884745 | No |
2624 | 12764 | 1160.4 | 453.61 | 41.2 | A new equation to estimate glomerular filtration rate. | Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef Coresh | Ann Intern Med | 2009 | 19414839 | Yes |
2625 | 1160 | 1160.0 | 28.23 | 28.2 | Rapid and sensitive sequence comparison with FASTP and FASTA. | W R Pearson | Methods Enzymol | 1990 | 2156132 | Yes |
2626 | 1160 | 1160.0 | 29.55 | 29.6 | Optimal experimental design for event-related fMRI. | A M Dale | Hum Brain Mapp | 1999 | 10524601 | Yes |
2627 | 1159 | 1159.0 | 22.3 | 22.3 | Contingent genetic regulatory events in T lymphocyte activation. | G R Crabtree | Science | 1989 | 2783497 | Yes |
2628 | 1159 | 1159.0 | 0.0 | 0.0 | Presynaptic regulation of catecholamine release. | S Z Langer | Biochem Pharmacol | 1974 | 4617579 | No |
2629 | 1159 | 1159.0 | 37.67 | 37.7 | Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. | J J Gross | J Pers Soc Psychol | 1998 | 9457784 | Yes |
2630 | 1159 | 1159.0 | 36.42 | 36.4 | Chronic disease management: what will it take to improve care for chronic illness? | E H Wagner | Eff Clin Pract | 1998 | 10345255 | No |
2631 | 1159 | 1159.0 | 28.2 | 28.2 | Pathways of oxidative damage. | James A Imlay | Annu Rev Microbiol | 2003 | 14527285 | No |
2632 | 2317 | 1158.5 | 54.58 | 27.3 | Can the pharmaceutical industry reduce attrition rates? | Ismail Kola, John Landis | Nat Rev Drug Discov | 2004 | 15286737 | No |
2633 | 1158 | 1158.0 | 45.31 | 45.3 | Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. | H V Gelboin | Physiol Rev | 1980 | 7001511 | No |
2634 | 1158 | 1158.0 | 23.37 | 23.4 | Lipid rafts: elusive or illusive? | Sean Munro | Cell | 2003 | 14622593 | No |
2635 | 1158 | 1158.0 | 37.94 | 37.9 | Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. | Charles A Dinarello | Blood | 2011 | 21304099 | No |
2636 | 1157 | 1157.0 | 30.96 | 31.0 | Psychological and neural mechanisms of the affective dimension of pain. | D D Price | Science | 2000 | 10846154 | No |
2637 | 1157 | 1157.0 | 29.44 | 29.4 | Primate anterior cingulate cortex: where motor control, drive and cognition interface. | T Paus | Nat Rev Neurosci | 2001 | 11389475 | No |
2638 | 4627 | 1156.8 | 127.12 | 31.8 | Microbial ecology: human gut microbes associated with obesity. | Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I Gordon | Nature | 2006 | 17183309 | Yes |
2639 | 2313 | 1156.5 | 62.92 | 31.5 | Imaging cognition II: An empirical review of 275 PET and fMRI studies. | R Cabeza, L Nyberg | J Cogn Neurosci | 2000 | 10769304 | No |
2640 | 3469 | 1156.3 | 0.0 | 0.0 | The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. | G Blessed, B E Tomlinson, M Roth | Br J Psychiatry | 1968 | 5662937 | Yes |
2641 | 1156 | 1156.0 | 21.23 | 21.2 | Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. | D Hanahan | Nature | 1985 | 2986015 | Yes |
2642 | 1156 | 1156.0 | 26.55 | 26.6 | Translating cell biology into therapeutic advances in Alzheimer's disease. | D J Selkoe | Nature | 1999 | 10392577 | No |
2643 | 2312 | 1156.0 | 47.9 | 23.9 | An automated method for finding molecular complexes in large protein interaction networks. | Gary D Bader, Christopher W V Hogue | BMC Bioinformatics | 2003 | 12525261 | Yes |
2644 | 8089 | 1155.6 | 298.54 | 42.6 | GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. | Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J Schünemann | BMJ | 2008 | 18436948 | Yes |
2645 | 2311 | 1155.5 | 70.42 | 35.2 | Recent advances in the phencyclidine model of schizophrenia. | D C Javitt, S R Zukin | Am J Psychiatry | 1991 | 1654746 | No |
2646 | 2311 | 1155.5 | 0.0 | 0.0 | Plasminogen: purification from human plasma by affinity chromatography. | D G Deutsch, E T Mertz | Science | 1970 | 5475635 | Yes |
2647 | 1155 | 1155.0 | 0.0 | 0.0 | RNA metabolism in the HeLa cell nucleus. | S Penman | J Mol Biol | 1966 | 5961144 | Yes |
2648 | 1155 | 1155.0 | 73.74 | 73.7 | Impingement lesions. | C S Neer | Clin Orthop Relat Res | 1983 | 6825348 | Yes |
2649 | 1155 | 1155.0 | 28.08 | 28.1 | Matrix proteoglycans: from molecular design to cellular function. | R V Iozzo | Annu Rev Biochem | 1998 | 9759499 | No |
2650 | 8080 | 1154.3 | 266.49 | 38.1 | AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. | Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J Olson | J Comput Chem | 2009 | 19399780 | Yes |
2651 | 1154 | 1154.0 | 0.0 | 0.0 | The concept of immunological surveillance. | F M Burnet | Prog Exp Tumor Res | 1970 | 4921480 | No |
2652 | 2308 | 1154.0 | 51.35 | 25.7 | Lymphocyte homing and homeostasis. | E C Butcher, L J Picker | Science | 1996 | 8600538 | No |
2653 | 2308 | 1154.0 | 64.32 | 32.2 | Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. | Gerard Talavera, Jose Castresana | Syst Biol | 2007 | 17654362 | Yes |
2654 | 2307 | 1153.5 | 0.0 | 0.0 | Quantitative determination of serum triglycerides by the use of enzymes. | G Bucolo, H David | Clin Chem | 1973 | 4703655 | Yes |
2655 | 2307 | 1153.5 | 59.82 | 29.9 | Microenvironmental regulation of metastasis. | Johanna A Joyce, Jeffrey W Pollard | Nat Rev Cancer | 2009 | 19279573 | No |
2656 | 1153 | 1153.0 | 0.0 | 0.0 | Selective coronary arteriography. I. A percutaneous transfemoral technic. | M P Judkins | Radiology | 1967 | 6048074 | Yes |
2657 | 2306 | 1153.0 | 97.1 | 48.5 | Reading senseless sentences: brain potentials reflect semantic incongruity. | M Kutas, S A Hillyard | Science | 1980 | 7350657 | Yes |
2658 | 1153 | 1153.0 | 33.61 | 33.6 | Papillary and follicular thyroid carcinoma. | M J Schlumberger | N Engl J Med | 1998 | 9445411 | No |
2659 | 3458 | 1152.7 | 0.0 | 0.0 | High resolution two-dimensional electrophoresis of basic as well as acidic proteins. | P Z O'Farrell, H M Goodman, P H O'Farrell | Cell | 1977 | 23215 | Yes |
2660 | 1152 | 1152.0 | 0.0 | 0.0 | Experience from a multicentre stroke register: a preliminary report. | S Hatano | Bull World Health Organ | 1976 | 1088404 | Yes |
2661 | 1152 | 1152.0 | 30.53 | 30.5 | Pathogenesis of dengue: challenges to molecular biology. | S B Halstead | Science | 1988 | 3277268 | No |
2662 | 3455 | 1151.7 | 109.18 | 36.4 | Dose translation from animal to human studies revisited. | Shannon Reagan-Shaw, Minakshi Nihal, Nihal Ahmad | FASEB J | 2008 | 17942826 | Yes |
2663 | 2303 | 1151.5 | 96.2 | 48.1 | Neoantigens in cancer immunotherapy. | Ton N Schumacher, Robert D Schreiber | Science | 2015 | 25838375 | No |
2664 | 1151 | 1151.0 | 30.09 | 30.1 | Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. | G Boden | Diabetes | 1997 | 8971073 | No |
2665 | 1151 | 1151.0 | 25.07 | 25.1 | Platelets in atherothrombosis. | Zaverio M Ruggeri | Nat Med | 2002 | 12411949 | No |
2666 | 1151 | 1151.0 | 32.23 | 32.2 | The biochemistry and medical significance of the flavonoids. | Bent H Havsteen | Pharmacol Ther | 2002 | 12453566 | No |
2667 | 1150 | 1150.0 | 25.93 | 25.9 | Cadherins: a molecular family important in selective cell-cell adhesion. | M Takeichi | Annu Rev Biochem | 1990 | 2197976 | No |
2668 | 4600 | 1150.0 | 101.03 | 25.3 | Interleukin-10 and the interleukin-10 receptor. | K W Moore, R de Waal Malefyt, R L Coffman, A O'Garra | Annu Rev Immunol | 2001 | 11244051 | No |
2669 | 2298 | 1149.0 | 0.0 | 0.0 | Solubilization of membranes by detergents. | A Helenius, K Simons | Biochim Biophys Acta | 1975 | 1091302 | No |
2670 | 1149 | 1149.0 | 0.0 | 0.0 | Optimal foraging, the marginal value theorem. | E L Charnov | Theor Popul Biol | 1976 | 1273796 | Yes |
2671 | 1149 | 1149.0 | 45.22 | 45.2 | Translating social ecological theory into guidelines for community health promotion. | D Stokols | Am J Health Promot | 1996 | 10159709 | No |
2672 | 1149 | 1149.0 | 0.0 | 0.0 | Diffusion-in-gel methods for immunological analysis. II. | O Ouchterlony | Prog Allergy | 1962 | 14482809 | Yes |
2673 | 2298 | 1149.0 | 59.08 | 29.5 | Drug delivery systems: entering the mainstream. | Theresa M Allen, Pieter R Cullis | Science | 2004 | 15031496 | Yes |
2674 | 3446 | 1148.7 | 100.75 | 33.6 | Nitric oxide and peroxynitrite in health and disease. | Pál Pacher, Joseph S Beckman, Lucas Liaudet | Physiol Rev | 2007 | 17237348 | No |
2675 | 2296 | 1148.0 | 156.96 | 78.5 | Facial nerve grading system. | J W House, D E Brackmann | Otolaryngol Head Neck Surg | 1985 | 3921901 | Yes |
2676 | 1148 | 1148.0 | 25.89 | 25.9 | Molecular physiology of low-voltage-activated t-type calcium channels. | Edward Perez-Reyes | Physiol Rev | 2003 | 12506128 | No |
2677 | 1148 | 1148.0 | 30.97 | 31.0 | Pain and emotion interactions in subregions of the cingulate gyrus. | Brent A Vogt | Nat Rev Neurosci | 2005 | 15995724 | No |
2678 | 1148 | 1148.0 | 0.0 | 0.0 | A simple objective technique for measuring flexibility in thinking. | E A Berg | J Gen Psychol | 1948 | 18889466 | Yes |
2679 | 2296 | 1148.0 | 66.42 | 33.2 | Alternative activation of macrophages: mechanism and functions. | Siamon Gordon, Fernando O Martinez | Immunity | 2010 | 20510870 | No |
2680 | 1147 | 1147.0 | 0.0 | 0.0 | Biogenic amines and the states of sleep. | M Jouvet | Science | 1969 | 4303225 | No |
2681 | 1147 | 1147.0 | 0.0 | 0.0 | The generalisation of student's problems when several different population variances are involved. | B L Welch | Biometrika | 1947 | 20287819 | Yes |
2682 | 2294 | 1147.0 | 97.62 | 48.8 | The future of immune checkpoint therapy. | Padmanee Sharma, James P Allison | Science | 2015 | 25838373 | No |
2683 | 2293 | 1146.5 | 64.66 | 32.3 | Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. | Ajay Kumar Gupta, Mona Gupta | Biomaterials | 2005 | 15626447 | No |
2684 | 1146 | 1146.0 | 35.66 | 35.7 | Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. | E N Bergman | Physiol Rev | 1990 | 2181501 | No |
2685 | 1146 | 1146.0 | 31.78 | 31.8 | Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. | U Mitzdorf | Physiol Rev | 1985 | 3880898 | No |
2686 | 1146 | 1146.0 | 36.17 | 36.2 | Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. | Felix Kratz | J Control Release | 2008 | 18582981 | No |
2687 | 1145 | 1145.0 | 0.0 | 0.0 | Radioimmunological determination of human C-peptide in serum. | L G Heding | Diabetologia | 1975 | 1239396 | Yes |
2688 | 1145 | 1145.0 | 32.42 | 32.4 | DNA topoisomerases. | M Gellert | Annu Rev Biochem | 1981 | 6267993 | No |
2689 | 1145 | 1145.0 | 26.87 | 26.9 | Mitochondrial transport of cations: channels, exchangers, and permeability transition. | P Bernardi | Physiol Rev | 1999 | 10508231 | No |
2690 | 1145 | 1145.0 | 37.18 | 37.2 | Endometriosis. | Serdar E Bulun | N Engl J Med | 2009 | 19144942 | No |
2691 | 2289 | 1144.5 | 46.89 | 23.4 | A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. | N C Andrews, D V Faller | Nucleic Acids Res | 1991 | 2041787 | Yes |
2692 | 2289 | 1144.5 | 66.45 | 33.2 | Increasing incidence of thyroid cancer in the United States, 1973-2002. | Louise Davies, H Gilbert Welch | JAMA | 2006 | 16684987 | Yes |
2693 | 2288 | 1144.0 | 0.0 | 0.0 | Growth of a rat neuroblastoma cell line in serum-free supplemented medium. | J E Bottenstein, G H Sato | Proc Natl Acad Sci U S A | 1979 | 284369 | Yes |
2694 | 1144 | 1144.0 | 0.0 | 0.0 | Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. | D B Clewell | J Bacteriol | 1972 | 4336693 | Yes |
2695 | 1144 | 1144.0 | 25.41 | 25.4 | The roles of intracellular protein-degradation pathways in neurodegeneration. | David C Rubinsztein | Nature | 2006 | 17051204 | No |
2696 | 3429 | 1143.0 | 0.0 | 0.0 | Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. | G M Wahl, M Stern, G R Stark | Proc Natl Acad Sci U S A | 1979 | 291033 | Yes |
2697 | 1143 | 1143.0 | 27.49 | 27.5 | Metastatic bone disease: clinical features, pathophysiology and treatment strategies. | R E Coleman | Cancer Treat Rev | 2001 | 11417967 | No |
2698 | 1143 | 1143.0 | 30.67 | 30.7 | Wound healing and its impairment in the diabetic foot. | Vincent Falanga | Lancet | 2005 | 16291068 | No |
2699 | 3429 | 1143.0 | 85.4 | 28.5 | Tissue cells feel and respond to the stiffness of their substrate. | Dennis E Discher, Paul Janmey, Yu-Li Wang | Science | 2005 | 16293750 | No |
2700 | 1143 | 1143.0 | 31.57 | 31.6 | Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. | G L Semenza | Oncogene | 2010 | 19946328 | No |
2701 | 3428 | 1142.7 | 70.46 | 23.5 | The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. | Fabio Martinon, Kimberly Burns, Jürg Tschopp | Mol Cell | 2002 | 12191486 | Yes |
2702 | 1142 | 1142.0 | 0.0 | 0.0 | Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. | J O Holloszy | J Biol Chem | 1967 | 4290225 | Yes |
2703 | 1142 | 1142.0 | 35.66 | 35.7 | Cytokinesis-block micronucleus cytome assay. | Michael Fenech | Nat Protoc | 2007 | 17546000 | Yes |
2704 | 2283 | 1141.5 | 0.0 | 0.0 | Construct validity in psychological tests. | L J Cronbach, P E Meehl | Psychol Bull | 1955 | 13245896 | Yes |
2705 | 3424 | 1141.3 | 125.25 | 41.8 | Rehospitalizations among patients in the Medicare fee-for-service program. | Stephen F Jencks, Mark V Williams, Eric A Coleman | N Engl J Med | 2009 | 19339721 | Yes |
2706 | 2282 | 1141.0 | 51.69 | 25.8 | The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. | P M Sharp, W H Li | Nucleic Acids Res | 1987 | 3547335 | Yes |
2707 | 1140 | 1140.0 | 46.09 | 46.1 | Social phobia. | M R Liebowitz | Mod Probl Pharmacopsychiatry | 1987 | 2885745 | Yes |
2708 | 1140 | 1140.0 | 0.0 | 0.0 | Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. | M M Weiser | J Biol Chem | 1973 | 4698230 | Yes |
2709 | 1140 | 1140.0 | 41.38 | 41.4 | Plasma perspective on strong field multiphoton ionization. | Corkum | Phys Rev Lett | 1993 | 10054556 | Yes |
2710 | 1140 | 1140.0 | 32.46 | 32.5 | How brains beware: neural mechanisms of emotional attention. | Patrik Vuilleumier | Trends Cogn Sci | 2005 | 16289871 | Yes |
2711 | 1140 | 1140.0 | 0.0 | 0.0 | A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. | R D Hotchkiss | Arch Biochem | 1948 | 18921848 | Yes |
2712 | 2279 | 1139.5 | 98.8 | 49.4 | The M1 and M2 paradigm of macrophage activation: time for reassessment. | Fernando O Martinez, Siamon Gordon | F1000Prime Rep | 2014 | 24669294 | No |
2713 | 1139 | 1139.0 | 34.44 | 34.4 | Effect of anoxia on ion distribution in the brain. | A J Hansen | Physiol Rev | 1985 | 3880896 | No |
2714 | 1139 | 1139.0 | 0.0 | 0.0 | Pathologic anatomy of the pancreas in juvenile diabetes mellitus. | W Gepts | Diabetes | 1965 | 5318831 | Yes |
2715 | 2278 | 1139.0 | 49.73 | 24.9 | Functions of lipid rafts in biological membranes. | D A Brown, E London | Annu Rev Cell Dev Biol | 1998 | 9891780 | No |
2716 | 1139 | 1139.0 | 23.24 | 23.2 | IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. | Yong-Jun Liu | Annu Rev Immunol | 2005 | 15771572 | No |
2717 | 2278 | 1139.0 | 76.05 | 38.0 | Accessories to the crime: functions of cells recruited to the tumor microenvironment. | Douglas Hanahan, Lisa M Coussens | Cancer Cell | 2012 | 22439926 | No |
2718 | 3416 | 1138.7 | 144.63 | 48.2 | Multiple imputation using chained equations: Issues and guidance for practice. | Ian R White, Patrick Royston, Angela M Wood | Stat Med | 2011 | 21225900 | Yes |
2719 | 6830 | 1138.3 | 182.94 | 30.5 | Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. | Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat Robles | Bioinformatics | 2005 | 16081474 | Yes |
2720 | 1138 | 1138.0 | 0.0 | 0.0 | Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. | S Z Langer | Br J Pharmacol | 1977 | 20190 | No |
2721 | 1138 | 1138.0 | 20.61 | 20.6 | Stem cells: units of development, units of regeneration, and units in evolution. | I L Weissman | Cell | 2000 | 10647940 | No |
2722 | 1138 | 1138.0 | 0.0 | 0.0 | Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. | R J Pennington | Biochem J | 1961 | 13734134 | Yes |
2723 | 1138 | 1138.0 | 25.95 | 25.9 | Neuroligins and neurexins link synaptic function to cognitive disease. | Thomas C Südhof | Nature | 2008 | 18923512 | No |
2724 | 2275 | 1137.5 | 93.85 | 46.9 | PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. | Daniel R Roe, Thomas E Cheatham | J Chem Theory Comput | 2013 | 26583988 | Yes |
2725 | 2274 | 1137.0 | 71.29 | 35.6 | Role of oxidized low density lipoprotein in atherogenesis. | J L Witztum, D Steinberg | J Clin Invest | 1991 | 1752940 | No |
2726 | 2274 | 1137.0 | 74.38 | 37.2 | An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. | O Johnell, J A Kanis | Osteoporos Int | 2006 | 16983459 | Yes |
2727 | 3410 | 1136.7 | 0.0 | 0.0 | Cytochemical identification of monocytes and granulocytes. | L T Yam, C Y Li, W H Crosby | Am J Clin Pathol | 1971 | 5549896 | Yes |
2728 | 1136 | 1136.0 | 0.0 | 0.0 | An improved fluorometric assay for DNA. | R T Hinegardner | Anal Biochem | 1971 | 5544593 | Yes |
2729 | 2272 | 1136.0 | 48.65 | 24.3 | Toll-like receptors in the induction of the innate immune response. | A Aderem, R J Ulevitch | Nature | 2000 | 10963608 | No |
2730 | 1136 | 1136.0 | 0.0 | 0.0 | Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. | A B Stavitsky | J Immunol | 1954 | 13163409 | Yes |
2731 | 3408 | 1136.0 | 101.31 | 33.8 | Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. | Günter Oberdörster, Eva Oberdörster, Jan Oberdörster | Environ Health Perspect | 2005 | 16002369 | No |
2732 | 1136 | 1136.0 | 25.45 | 25.4 | Solving structures of protein complexes by molecular replacement with Phaser. | Airlie J McCoy | Acta Crystallogr D Biol Crystallogr | 2007 | 17164524 | Yes |
2733 | 1136 | 1136.0 | 0.0 | 0.0 | pA, a new scale for the measurement of drug antagonism. | H O Schild | Br J Pharmacol Chemother | 1947 | 20258355 | Yes |
2734 | 3406 | 1135.3 | 69.45 | 23.2 | Predicting coiled coils from protein sequences. | A Lupas, M Van Dyke, J Stock | Science | 1991 | 2031185 | Yes |
2735 | 1135 | 1135.0 | 19.74 | 19.7 | Mitotic kinases as regulators of cell division and its checkpoints. | E A Nigg | Nat Rev Mol Cell Biol | 2001 | 11413462 | No |
2736 | 1135 | 1135.0 | 31.42 | 31.4 | Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. | Earl S Ford | Diabetes Care | 2005 | 15983333 | No |
2737 | 1134 | 1134.0 | 39.94 | 39.9 | Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. | A J Alpert | J Chromatogr | 1990 | 2324207 | Yes |
2738 | 2267 | 1133.5 | 142.74 | 71.4 | The amyloid hypothesis of Alzheimer's disease at 25 years. | Dennis J Selkoe, John Hardy | EMBO Mol Med | 2016 | 27025652 | No |
2739 | 2266 | 1133.0 | 0.0 | 0.0 | Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. | J D McGhee, P H von Hippel | J Mol Biol | 1974 | 4416620 | Yes |
2740 | 1133 | 1133.0 | 0.0 | 0.0 | Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. | A R Midgley | Endocrinology | 1966 | 5950482 | Yes |
2741 | 1133 | 1133.0 | 26.9 | 26.9 | Brain tumors. | L M DeAngelis | N Engl J Med | 2001 | 11150363 | No |
2742 | 2264 | 1132.0 | 92.28 | 46.1 | The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. | R Näätänen, T Picton | Psychophysiology | 1987 | 3615753 | Yes |
2743 | 1132 | 1132.0 | 39.1 | 39.1 | Breakthrough of the year 2013. Cancer immunotherapy. | Jennifer Couzin-Frankel | Science | 2013 | 24357284 | No |
2744 | 1131 | 1131.0 | 22.31 | 22.3 | Mechanisms and consequences of activation of protein kinase B/Akt. | J Downward | Curr Opin Cell Biol | 1998 | 9561851 | No |
2745 | 1131 | 1131.0 | 32.02 | 32.0 | Plant productivity and environment. | J S Boyer | Science | 1982 | 17808529 | Yes |
2746 | 1131 | 1131.0 | 63.45 | 63.5 | Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. | Kevin A Hallgren | Tutor Quant Methods Psychol | 2012 | 22833776 | Yes |
2747 | 1131 | 1131.0 | 88.32 | 88.3 | Metazoan MicroRNAs. | David P Bartel | Cell | 2018 | 29570994 | No |
2748 | 2261 | 1130.5 | 0.0 | 0.0 | Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. | R B Gustilo, J T Anderson | J Bone Joint Surg Am | 1976 | 773941 | Yes |
2749 | 2261 | 1130.5 | 75.62 | 37.8 | Atomic structure and chemistry of human serum albumin. | X M He, D C Carter | Nature | 1992 | 1630489 | Yes |
2750 | 2260 | 1130.0 | 0.0 | 0.0 | Radiological demarcation of cemented sockets in total hip replacement. | J G DeLee, J Charnley | Clin Orthop Relat Res | 1976 | 991504 | Yes |
2751 | 1130 | 1130.0 | 36.46 | 36.5 | Molecular biology of steroid hormone synthesis. | W L Miller | Endocr Rev | 1988 | 3061784 | No |
2752 | 1130 | 1130.0 | 78.76 | 78.8 | The problem of rigor in qualitative research. | M Sandelowski | ANS Adv Nurs Sci | 1986 | 3083765 | Yes |
2753 | 1130 | 1130.0 | 34.91 | 34.9 | Low-molecular-weight heparins. | J I Weitz | N Engl J Med | 1997 | 9278467 | No |
2754 | 3390 | 1130.0 | 72.7 | 24.2 | Toll-like receptors: critical proteins linking innate and acquired immunity. | S Akira, K Takeda, T Kaisho | Nat Immunol | 2001 | 11477402 | No |
2755 | 1130 | 1130.0 | 31.69 | 31.7 | Mitochondrial fusion and fission in cell life and death. | Benedikt Westermann | Nat Rev Mol Cell Biol | 2010 | 21102612 | No |
2756 | 4517 | 1129.2 | 161.97 | 40.5 | Guidelines for the process of cross-cultural adaptation of self-report measures. | D E Beaton, C Bombardier, F Guillemin, M B Ferraz | Spine (Phila Pa 1976) | 2000 | 11124735 | No |
2757 | 4515 | 1128.8 | 112.05 | 28.0 | Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. | H Nielsen, J Engelbrecht, S Brunak, G von Heijne | Protein Eng | 1997 | 9051728 | Yes |
2758 | 2257 | 1128.5 | 62.17 | 31.1 | Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. | Barry J Everitt, Trevor W Robbins | Nat Neurosci | 2005 | 16251991 | No |
2759 | 2256 | 1128.0 | 44.42 | 22.2 | Multiple nuclear factors interact with the immunoglobulin enhancer sequences. | R Sen, D Baltimore | Cell | 1986 | 3091258 | Yes |
2760 | 1128 | 1128.0 | 43.48 | 43.5 | On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. | D Collen | Thromb Haemost | 1980 | 6450468 | No |
2761 | 4512 | 1128.0 | 133.14 | 33.3 | Place navigation impaired in rats with hippocampal lesions. | R G Morris, P Garrud, J N Rawlins, J O'Keefe | Nature | 1982 | 7088155 | Yes |
2762 | 2255 | 1127.5 | 54.43 | 27.2 | Emerging roles of caspase-3 in apoptosis. | A G Porter, R U Jänicke | Cell Death Differ | 1999 | 10200555 | No |
2763 | 2255 | 1127.5 | 71.35 | 35.7 | Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). | Kathryn M Connor, Jonathan R T Davidson | Depress Anxiety | 2003 | 12964174 | Yes |
2764 | 2255 | 1127.5 | 51.36 | 25.7 | Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. | Eugenia E Calle, Rudolf Kaaks | Nat Rev Cancer | 2004 | 15286738 | No |
2765 | 1127 | 1127.0 | 0.0 | 0.0 | An approach for the treatment of penile carcinoma. | R M Cabanas | Cancer | 1977 | 837331 | Yes |
2766 | 2254 | 1127.0 | 63.99 | 32.0 | Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. | R G Phillips, J E LeDoux | Behav Neurosci | 1992 | 1590953 | Yes |
2767 | 1127 | 1127.0 | 28.83 | 28.8 | Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. | I J Fidler | Cancer Res | 1990 | 1698118 | Yes |
2768 | 1127 | 1127.0 | 33.97 | 34.0 | Unstable angina. A classification. | E Braunwald | Circulation | 1989 | 2752565 | Yes |
2769 | 2254 | 1127.0 | 68.82 | 34.4 | A cognitive model of posttraumatic stress disorder. | A Ehlers, D M Clark | Behav Res Ther | 2000 | 10761279 | No |
2770 | 1127 | 1127.0 | 27.02 | 27.0 | The prefrontal cortex and cognitive control. | E K Miller | Nat Rev Neurosci | 2000 | 11252769 | No |
2771 | 1127 | 1127.0 | 30.79 | 30.8 | Polymer conjugates as anticancer nanomedicines. | Ruth Duncan | Nat Rev Cancer | 2006 | 16900224 | No |
2772 | 4504 | 1126.0 | 108.65 | 27.2 | Base-calling of automated sequencer traces using phred. I. Accuracy assessment. | B Ewing, L Hillier, M C Wendl, P Green | Genome Res | 1998 | 9521921 | Yes |
2773 | 1126 | 1126.0 | 32.01 | 32.0 | The induction of pain: an integrative review. | M J Millan | Prog Neurobiol | 1999 | 9987804 | No |
2774 | 1126 | 1126.0 | 34.14 | 34.1 | The structure of common mental disorders. | R F Krueger | Arch Gen Psychiatry | 1999 | 10530634 | Yes |
2775 | 1126 | 1126.0 | 36.52 | 36.5 | Risk and maintenance factors for eating pathology: a meta-analytic review. | Eric Stice | Psychol Bull | 2002 | 12206196 | No |
2776 | 1126 | 1126.0 | 25.4 | 25.4 | Microglia as a source and target of cytokines. | Uwe-Karsten Hanisch | Glia | 2002 | 12379902 | No |
2777 | 2251 | 1125.5 | 61.38 | 30.7 | Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. | M J Casadaban, S N Cohen | J Mol Biol | 1980 | 6997493 | Yes |
2778 | 2251 | 1125.5 | 66.6 | 33.3 | Excitatory amino acids as a final common pathway for neurologic disorders. | S A Lipton, P A Rosenberg | N Engl J Med | 1994 | 7905600 | No |
2779 | 1125 | 1125.0 | 24.37 | 24.4 | Stem cells in the central nervous system. | R McKay | Science | 1997 | 9082987 | No |
2780 | 1125 | 1125.0 | 0.0 | 0.0 | On the law of effect. | R J Herrnstein | J Exp Anal Behav | 1970 | 16811440 | Yes |
2781 | 1125 | 1125.0 | 37.64 | 37.6 | Mitochondria and cancer. | Douglas C Wallace | Nat Rev Cancer | 2012 | 23001348 | No |
2782 | 3373 | 1124.3 | 87.84 | 29.3 | Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. | C R Woese, O Kandler, M L Wheelis | Proc Natl Acad Sci U S A | 1990 | 2112744 | Yes |
2783 | 2248 | 1124.0 | 0.0 | 0.0 | Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. | L M Siegel, K J Monty | Biochim Biophys Acta | 1966 | 5329026 | Yes |
2784 | 2247 | 1123.5 | 0.0 | 0.0 | Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. | H H Ussing, K Zerahn | Acta Physiol Scand | 1951 | 14868510 | Yes |
2785 | 1123 | 1123.0 | 33.32 | 33.3 | The fetal and infant origins of adult disease. | D J Barker | BMJ | 1990 | 2252919 | No |
2786 | 1123 | 1123.0 | 33.79 | 33.8 | Determinants of tumor blood flow: a review. | R K Jain | Cancer Res | 1988 | 3282647 | No |
2787 | 1123 | 1123.0 | 0.0 | 0.0 | Metabolic stability and epigenesis in randomly constructed genetic nets. | S A Kauffman | J Theor Biol | 1969 | 5803332 | Yes |
2788 | 1123 | 1123.0 | 41.01 | 41.0 | Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. | W A Catterall | Annu Rev Pharmacol Toxicol | 1980 | 6247957 | No |
2789 | 1123 | 1123.0 | 30.43 | 30.4 | The chromosomal basis of human neoplasia. | J J Yunis | Science | 1983 | 6336310 | Yes |
2790 | 1123 | 1123.0 | 22.39 | 22.4 | Regulation of transcription by MAP kinase cascades. | R Treisman | Curr Opin Cell Biol | 1996 | 8791420 | No |
2791 | 1123 | 1123.0 | 30.62 | 30.6 | Hydrogen sulphide and its therapeutic potential. | Csaba Szabó | Nat Rev Drug Discov | 2007 | 17948022 | No |
2792 | 1123 | 1123.0 | 29.37 | 29.4 | Non-Smad pathways in TGF-beta signaling. | Ying E Zhang | Cell Res | 2009 | 19114990 | No |
2793 | 1123 | 1123.0 | 38.15 | 38.1 | phangorn: phylogenetic analysis in R. | Klaus Peter Schliep | Bioinformatics | 2011 | 21169378 | Yes |
2794 | 1123 | 1123.0 | 28.66 | 28.7 | Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. | Christof M Niemeyer | Angew Chem Int Ed Engl | 2001 | 29712109 | No |
2795 | 1122 | 1122.0 | 59.78 | 59.8 | Nonalcoholic fatty liver disease: a systematic review. | Mary E Rinella | JAMA | 2015 | 26057287 | No |
2796 | 1121 | 1121.0 | 40.51 | 40.5 | The LMS method for constructing normalized growth standards. | T J Cole | Eur J Clin Nutr | 1990 | 2354692 | Yes |
2797 | 1121 | 1121.0 | 26.65 | 26.6 | Amyloid, the presenilins and Alzheimer's disease. | J Hardy | Trends Neurosci | 1997 | 9106355 | No |
2798 | 2242 | 1121.0 | 41.61 | 20.8 | Stats: transcriptional control and biological impact. | David E Levy, J E Darnell | Nat Rev Mol Cell Biol | 2002 | 12209125 | No |
2799 | 2241 | 1120.5 | 142.03 | 71.0 | A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. | E S Grood, W J Suntay | J Biomech Eng | 1983 | 6865355 | Yes |
2800 | 1120 | 1120.0 | 33.2 | 33.2 | Cell surface interactions with extracellular materials. | K M Yamada | Annu Rev Biochem | 1983 | 6351729 | No |
2801 | 1120 | 1120.0 | 25.26 | 25.3 | Physiological concentrations of purines and pyrimidines. | T W Traut | Mol Cell Biochem | 1994 | 7877593 | No |
2802 | 1120 | 1120.0 | 26.81 | 26.8 | Production of recombinant protein therapeutics in cultivated mammalian cells. | Florian M Wurm | Nat Biotechnol | 2004 | 15529164 | No |
2803 | 10073 | 1119.2 | 670.83 | 74.5 | Cancer statistics in China, 2015. | Wanqing Chen, Rongshou Zheng, Peter D Baade, Siwei Zhang, Hongmei Zeng, Freddie Bray, Ahmedin Jemal, Xue Qin Yu, Jie He | CA Cancer J Clin | 2016 | 26808342 | Yes |
2804 | 1119 | 1119.0 | 0.0 | 0.0 | Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. | J Altman | J Comp Neurol | 1969 | 5361244 | Yes |
2805 | 1119 | 1119.0 | 23.44 | 23.4 | Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. | Harold F Dvorak | J Clin Oncol | 2002 | 12409337 | No |
2806 | 3356 | 1118.7 | 78.23 | 26.1 | Hepatocellular carcinoma. | Josep M Llovet, Andrew Burroughs, Jordi Bruix | Lancet | 2003 | 14667750 | No |
2807 | 4474 | 1118.5 | 102.16 | 25.5 | Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. | J E Walker, M Saraste, M J Runswick, N J Gay | EMBO J | 1982 | 6329717 | Yes |
2808 | 4474 | 1118.5 | 105.15 | 26.3 | SCOP: a structural classification of proteins database for the investigation of sequences and structures. | A G Murzin, S E Brenner, T Hubbard, C Chothia | J Mol Biol | 1995 | 7723011 | Yes |
2809 | 1118 | 1118.0 | 30.92 | 30.9 | Diseases of the mitochondrial DNA. | D C Wallace | Annu Rev Biochem | 1992 | 1497308 | No |
2810 | 1118 | 1118.0 | 0.0 | 0.0 | 6-Hydroxy-dopamine induced degeneration of central monoamine neurons. | U Ungerstedt | Eur J Pharmacol | 1968 | 5718510 | Yes |
2811 | 1118 | 1118.0 | 26.57 | 26.6 | Allelic discrimination using fluorogenic probes and the 5' nuclease assay. | K J Livak | Genet Anal | 1999 | 10084106 | Yes |
2812 | 1118 | 1118.0 | 31.31 | 31.3 | Neural simulation of action: a unifying mechanism for motor cognition. | M Jeannerod | Neuroimage | 2001 | 11373140 | No |
2813 | 1118 | 1118.0 | 26.01 | 26.0 | Neurobiology of Pavlovian fear conditioning. | S Maren | Annu Rev Neurosci | 2001 | 11520922 | No |
2814 | 2236 | 1118.0 | 64.02 | 32.0 | Meeting of minds: the medial frontal cortex and social cognition. | David M Amodio, Chris D Frith | Nat Rev Neurosci | 2006 | 16552413 | No |
2815 | 1117 | 1117.0 | 23.93 | 23.9 | Mutator phenotype may be required for multistage carcinogenesis. | L A Loeb | Cancer Res | 1991 | 2039987 | No |
2816 | 1117 | 1117.0 | 33.78 | 33.8 | Reducing children's television viewing to prevent obesity: a randomized controlled trial. | T N Robinson | JAMA | 1999 | 10546696 | Yes |
2817 | 2233 | 1116.5 | 48.34 | 24.2 | Atherosclerosis. the road ahead. | C K Glass, J L Witztum | Cell | 2001 | 11239408 | No |
2818 | 1116 | 1116.0 | 35.01 | 35.0 | Protein damage and degradation by oxygen radicals. I. general aspects. | K J Davies | J Biol Chem | 1987 | 3036875 | Yes |
2819 | 2232 | 1116.0 | 67.05 | 33.5 | Nitric oxide synthases in mammals. | R G Knowles, S Moncada | Biochem J | 1994 | 7510950 | No |
2820 | 1116 | 1116.0 | 25.81 | 25.8 | Recognition and processing of ubiquitin-protein conjugates by the proteasome. | Daniel Finley | Annu Rev Biochem | 2009 | 19489727 | No |
2821 | 1115 | 1115.0 | 0.0 | 0.0 | Voluntary strength and fatigue. | P A Merton | J Physiol | 1954 | 13152698 | Yes |
2822 | 1115 | 1115.0 | 30.59 | 30.6 | Q-ball imaging. | David S Tuch | Magn Reson Med | 2004 | 15562495 | Yes |
2823 | 2230 | 1115.0 | 64.85 | 32.4 | The cognitive control of emotion. | Kevin N Ochsner, James J Gross | Trends Cogn Sci | 2005 | 15866151 | No |
2824 | 1115 | 1115.0 | 48.03 | 48.0 | Cytokines in inflammatory bowel disease. | Markus F Neurath | Nat Rev Immunol | 2014 | 24751956 | No |
2825 | 2229 | 1114.5 | 51.93 | 26.0 | Toll-like receptors in innate immunity. | Kiyoshi Takeda, Shizuo Akira | Int Immunol | 2005 | 15585605 | No |
2826 | 1114 | 1114.0 | 0.0 | 0.0 | Cytoprotection by prostaglandins. | A Robert | Gastroenterology | 1979 | 38173 | Yes |
2827 | 1114 | 1114.0 | 28.46 | 28.5 | Two distinct classes of carbohydrate-recognition domains in animal lectins. | K Drickamer | J Biol Chem | 1988 | 3290208 | No |
2828 | 2228 | 1114.0 | 60.89 | 30.4 | Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. | R A Ignotz, J Massagué | J Biol Chem | 1986 | 3456347 | Yes |
2829 | 1114 | 1114.0 | 0.0 | 0.0 | Preliminary Trial Of Carisoprodol In Multiple Sclerosis. | B Ashworth | Practitioner | 1964 | 14143329 | Yes |
2830 | 1114 | 1114.0 | 0.0 | 0.0 | The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. | R E Hope-Simpson | Proc R Soc Med | 1965 | 14267505 | Yes |
2831 | 1113 | 1113.0 | 57.89 | 57.9 | Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. | Anna Maria Carlsson | Pain | 1983 | 6602967 | Yes |
2832 | 2226 | 1113.0 | 44.27 | 22.1 | NF-kappaB at the crossroads of life and death. | Michael Karin, Anning Lin | Nat Immunol | 2002 | 11875461 | No |
2833 | 1113 | 1113.0 | 23.58 | 23.6 | Basement membranes: structure, assembly and role in tumour angiogenesis. | Raghu Kalluri | Nat Rev Cancer | 2003 | 12778132 | No |
2834 | 1113 | 1113.0 | 32.4 | 32.4 | Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. | Antoine Bechara | Nat Neurosci | 2005 | 16251988 | No |
2835 | 1112 | 1112.0 | 0.0 | 0.0 | Studies on histones. 7. Preparative methods for histone fractions from calf thymus. | E W Johns | Biochem J | 1964 | 5840387 | Yes |
2836 | 1112 | 1112.0 | 25.42 | 25.4 | Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. | M Kozak | Nucleic Acids Res | 1981 | 7301588 | Yes |
2837 | 1112 | 1112.0 | 25.91 | 25.9 | Human natural killer cells. | Michael A Caligiuri | Blood | 2008 | 18650461 | No |
2838 | 1112 | 1112.0 | 40.95 | 41.0 | The amazing osteocyte. | Lynda F Bonewald | J Bone Miner Res | 2011 | 21254230 | No |
2839 | 2223 | 1111.5 | 61.91 | 31.0 | Epidemiology and outcomes of osteoporotic fractures. | Steven R Cummings, L Joseph Melton | Lancet | 2002 | 12049882 | No |
2840 | 1111 | 1111.0 | 31.25 | 31.2 | Internal models for motor control and trajectory planning. | M Kawato | Curr Opin Neurobiol | 1999 | 10607637 | No |
2841 | 3333 | 1111.0 | 76.14 | 25.4 | Adjusting batch effects in microarray expression data using empirical Bayes methods. | W Evan Johnson, Cheng Li, Ariel Rabinovic | Biostatistics | 2007 | 16632515 | Yes |
2842 | 1110 | 1110.0 | 31.38 | 31.4 | Normalization of cell responses in cat striate cortex. | D J Heeger | Vis Neurosci | 1992 | 1504027 | Yes |
2843 | 1110 | 1110.0 | 29.33 | 29.3 | Neural systems for recognizing emotion. | Ralph Adolphs | Curr Opin Neurobiol | 2002 | 12015233 | No |
2844 | 1110 | 1110.0 | 34.22 | 34.2 | High prevalence of vitamin D inadequacy and implications for health. | Michael F Holick | Mayo Clin Proc | 2006 | 16529140 | No |
2845 | 2219 | 1109.5 | 79.39 | 39.7 | Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. | Riccardo Lencioni, Josep M Llovet | Semin Liver Dis | 2010 | 20175033 | No |
2846 | 7764 | 1109.1 | 160.94 | 23.0 | Exploration, normalization, and summaries of high density oligonucleotide array probe level data. | Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P Speed | Biostatistics | 2003 | 12925520 | Yes |
2847 | 1109 | 1109.0 | 46.87 | 46.9 | A cochlear frequency-position function for several species--29 years later. | D D Greenwood | J Acoust Soc Am | 1990 | 2373794 | Yes |
2848 | 1109 | 1109.0 | 0.0 | 0.0 | Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units. | C M Venkatachalam | Biopolymers | 1968 | 5685102 | Yes |
2849 | 1109 | 1109.0 | 103.97 | 104.0 | The analysis of errors in orthodontic measurements. | W J Houston | Am J Orthod | 1983 | 6573846 | Yes |
2850 | 1109 | 1109.0 | 27.7 | 27.7 | Metabolism and functions of glutathione in brain. | R Dringen | Prog Neurobiol | 2000 | 10880854 | No |
2851 | 2218 | 1109.0 | 82.25 | 41.1 | How good are my data and what is the resolution? | Philip R Evans, Garib N Murshudov | Acta Crystallogr D Biol Crystallogr | 2013 | 23793146 | Yes |
2852 | 1107 | 1107.0 | 0.0 | 0.0 | Structure of chromatin. | R D Kornberg | Annu Rev Biochem | 1977 | 332067 | No |
2853 | 1107 | 1107.0 | 41.56 | 41.6 | The P300 wave of the human event-related potential. | T W Picton | J Clin Neurophysiol | 1992 | 1464675 | No |
2854 | 2214 | 1107.0 | 50.69 | 25.3 | Adaptive protein evolution at the Adh locus in Drosophila. | J H McDonald, M Kreitman | Nature | 1991 | 1904993 | Yes |
2855 | 1107 | 1107.0 | 28.78 | 28.8 | Linkage strategies for genetically complex traits. I. Multilocus models. | N Risch | Am J Hum Genet | 1990 | 2301392 | Yes |
2856 | 1107 | 1107.0 | 21.19 | 21.2 | Luciferase reporter gene vectors for analysis of promoters and enhancers. | S K Nordeen | Biotechniques | 1988 | 2908509 | Yes |
2857 | 1107 | 1107.0 | 46.04 | 46.0 | Bone "mass" and the "mechanostat": a proposal. | H M Frost | Anat Rec | 1987 | 3688455 | Yes |
2858 | 1107 | 1107.0 | 21.99 | 22.0 | Microarray data normalization and transformation. | John Quackenbush | Nat Genet | 2002 | 12454644 | No |
2859 | 1107 | 1107.0 | 0.0 | 0.0 | The powerful placebo. | H K Beecher | J Am Med Assoc | 1955 | 13271123 | Yes |
2860 | 2213 | 1106.5 | 49.21 | 24.6 | Prediction of protein secondary structure at better than 70% accuracy. | B Rost, C Sander | J Mol Biol | 1993 | 8345525 | Yes |
2861 | 2213 | 1106.5 | 0.0 | 0.0 | Microdroplet Assay Of Human Serum Cytotoxins. | P I Terasaki, J D Mcclelland | Nature | 1964 | 14248725 | Yes |
2862 | 2212 | 1106.0 | 44.03 | 22.0 | Homeobox genes and axial patterning. | W McGinnis, R Krumlauf | Cell | 1992 | 1346368 | No |
2863 | 1106 | 1106.0 | 37.74 | 37.7 | Chemoprevention of cancer. | L W Wattenberg | Cancer Res | 1985 | 3880665 | No |
2864 | 1106 | 1106.0 | 23.62 | 23.6 | ALSCRIPT: a tool to format multiple sequence alignments. | G J Barton | Protein Eng | 1993 | 8433969 | Yes |
2865 | 6636 | 1106.0 | 230.9 | 38.5 | The occurrence of sleep-disordered breathing among middle-aged adults. | T Young, M Palta, J Dempsey, J Skatrud, S Weber, S Badr | N Engl J Med | 1993 | 8464434 | Yes |
2866 | 1106 | 1106.0 | 31.18 | 31.2 | Leishmaniasis. | B L Herwaldt | Lancet | 1999 | 10513726 | No |
2867 | 1106 | 1106.0 | 36.34 | 36.3 | Delirium in older persons. | Sharon K Inouye | N Engl J Med | 2006 | 16540616 | No |
2868 | 2211 | 1105.5 | 46.21 | 23.1 | Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. | G A Gonzalez, M R Montminy | Cell | 1989 | 2573431 | Yes |
2869 | 1105 | 1105.0 | 35.5 | 35.5 | Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. | J E Oesterling | J Urol | 1991 | 1707989 | No |
2870 | 2210 | 1105.0 | 96.95 | 48.5 | Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. | P R Hunter, M A Gaston | J Clin Microbiol | 1988 | 3069867 | Yes |
2871 | 1105 | 1105.0 | 36.47 | 36.5 | Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. | Ronald A Hites | Environ Sci Technol | 2004 | 14998004 | Yes |
2872 | 1105 | 1105.0 | 28.79 | 28.8 | Overview of general physiologic features and functions of vitamin D. | Hector F DeLuca | Am J Clin Nutr | 2004 | 15585789 | No |
2873 | 1105 | 1105.0 | 52.21 | 52.2 | Working memory: theories, models, and controversies. | Alan Baddeley | Annu Rev Psychol | 2012 | 21961947 | No |
2874 | 1104 | 1104.0 | 0.0 | 0.0 | Intra-sexual selection in Drosophila. | A J Bateman | Heredity (Edinb) | 1948 | 18103134 | Yes |
2875 | 2207 | 1103.5 | 44.63 | 22.3 | Proliferation, cell cycle and apoptosis in cancer. | G I Evan, K H Vousden | Nature | 2001 | 11357141 | No |
2876 | 2206 | 1103.0 | 63.61 | 31.8 | Ageing and Parkinson's disease: substantia nigra regional selectivity. | J M Fearnley, A J Lees | Brain | 1991 | 1933245 | Yes |
2877 | 1103 | 1103.0 | 43.45 | 43.5 | Molecular aspects of ligand binding to serum albumin. | U Kragh-Hansen | Pharmacol Rev | 1981 | 7027277 | No |
2878 | 2206 | 1103.0 | 69.88 | 34.9 | Natural products as sources of new drugs over the last 25 years. | David J Newman, Gordon M Cragg | J Nat Prod | 2007 | 17309302 | No |
2879 | 1103 | 1103.0 | 41.48 | 41.5 | The role of autophagy in neurodegenerative disease. | Ralph A Nixon | Nat Med | 2013 | 23921753 | No |
2880 | 3307 | 1102.3 | 0.0 | 0.0 | Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. | M Hamberg, J Svensson, B Samuelsson | Proc Natl Acad Sci U S A | 1975 | 1059088 | Yes |
2881 | 6614 | 1102.3 | 218.17 | 36.4 | A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. | Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier | Science | 2012 | 22745249 | Yes |
2882 | 2204 | 1102.0 | 71.21 | 35.6 | Excitatory amino acid transmitters. | J C Watkins, R H Evans | Annu Rev Pharmacol Toxicol | 1981 | 6112965 | No |
2883 | 5507 | 1101.4 | 218.12 | 43.6 | The hallmarks of aging. | Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer | Cell | 2013 | 23746838 | No |
2884 | 1101 | 1101.0 | 23.12 | 23.1 | Differentiation and proliferation of hematopoietic stem cells. | M Ogawa | Blood | 1993 | 8499622 | No |
2885 | 8808 | 1101.0 | 274.05 | 34.3 | The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. | Ziad S Nasreddine, Natalie A Phillips, Valérie Bédirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard Chertkow | J Am Geriatr Soc | 2005 | 15817019 | Yes |
2886 | 1101 | 1101.0 | 30.82 | 30.8 | Physiology and pathophysiology of purinergic neurotransmission. | Geoffrey Burnstock | Physiol Rev | 2007 | 17429044 | No |
2887 | 1101 | 1101.0 | 0.0 | 0.0 | Knee joint changes after meniscectomy. | T J Fairbank | J Bone Joint Surg Br | 1948 | 18894618 | Yes |
2888 | 4402 | 1100.5 | 111.06 | 27.8 | Autophagy fights disease through cellular self-digestion. | Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky | Nature | 2008 | 18305538 | No |
2889 | 1100 | 1100.0 | 41.67 | 41.7 | Omega-3 fatty acids in health and disease and in growth and development. | A P Simopoulos | Am J Clin Nutr | 1991 | 1908631 | No |
2890 | 2200 | 1100.0 | 0.0 | 0.0 | Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. | R J Britten, D E Kohne | Science | 1968 | 4874239 | Yes |
2891 | 1100 | 1100.0 | 24.21 | 24.2 | An overview of epithelio-mesenchymal transformation. | E D Hay | Acta Anat (Basel) | 1995 | 8714286 | No |
2892 | 1100 | 1100.0 | 29.66 | 29.7 | The neurobiology of stress: from serendipity to clinical relevance. | B S McEwen | Brain Res | 2000 | 11119695 | No |
2893 | 2200 | 1100.0 | 0.0 | 0.0 | Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. | A H Coons, M H Kaplan | J Exp Med | 1950 | 15395569 | Yes |
2894 | 3299 | 1099.7 | 106.53 | 35.5 | MR diffusion tensor spectroscopy and imaging. | P J Basser, J Mattiello, D LeBihan | Biophys J | 1994 | 8130344 | Yes |
2895 | 2198 | 1099.0 | 0.0 | 0.0 | Construction of phylogenetic trees. | W M Fitch, E Margoliash | Science | 1967 | 5334057 | No |
2896 | 1099 | 1099.0 | 0.0 | 0.0 | The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion. | S Roseman | Chem Phys Lipids | 1970 | 5476326 | Yes |
2897 | 1099 | 1099.0 | 0.0 | 0.0 | A cytoarchitectonic atlas of the spinal cord in the cat. | B Rexed | J Comp Neurol | 1954 | 13163236 | Yes |
2898 | 1099 | 1099.0 | 0.0 | 0.0 | The relation of the trail making test to organic brain damage. | R M Reitan | J Consult Psychol | 1955 | 13263471 | Yes |
2899 | 4393 | 1098.2 | 105.0 | 26.2 | Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. | G L Wang, B H Jiang, E A Rue, G L Semenza | Proc Natl Acad Sci U S A | 1995 | 7539918 | Yes |
2900 | 1098 | 1098.0 | 24.83 | 24.8 | The molecular biology of leukocyte chemoattractant receptors. | P M Murphy | Annu Rev Immunol | 1994 | 8011292 | No |
2901 | 2196 | 1098.0 | 41.12 | 20.6 | Hedgehog signaling in animal development: paradigms and principles. | P W Ingham, A P McMahon | Genes Dev | 2001 | 11731473 | No |
2902 | 1098 | 1098.0 | 0.0 | 0.0 | Inherited Antithrombin Deficiency Causing Thrombophilia. | O Egeberg | Thromb Diath Haemorrh | 1965 | 14347873 | Yes |
2903 | 1098 | 1098.0 | 30.43 | 30.4 | Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. | Paul Willner | Neuropsychobiology | 2005 | 16037678 | No |
2904 | 2196 | 1098.0 | 62.19 | 31.1 | A neurotrophic model for stress-related mood disorders. | Ronald S Duman, Lisa M Monteggia | Biol Psychiatry | 2006 | 16631126 | No |
2905 | 5487 | 1097.4 | 190.43 | 38.1 | Posttraumatic stress disorder in the National Comorbidity Survey. | R C Kessler, A Sonnega, E Bromet, M Hughes, C B Nelson | Arch Gen Psychiatry | 1995 | 7492257 | Yes |
2906 | 1097 | 1097.0 | 0.0 | 0.0 | Sex-hormone-binding globulin. | D C Anderson | Clin Endocrinol (Oxf) | 1974 | 4134992 | No |
2907 | 1097 | 1097.0 | 30.98 | 31.0 | Pharmacology of cannabinoid CB1 and CB2 receptors. | R G Pertwee | Pharmacol Ther | 1997 | 9336020 | No |
2908 | 2193 | 1096.5 | 47.53 | 23.8 | The mammalian unfolded protein response. | Martin Schröder, Randal J Kaufman | Annu Rev Biochem | 2005 | 15952902 | No |
2909 | 2193 | 1096.5 | 131.43 | 65.7 | mTOR Signaling in Growth, Metabolism, and Disease. | Robert A Saxton, David M Sabatini | Cell | 2017 | 28283069 | No |
2910 | 4385 | 1096.2 | 120.52 | 30.1 | Prevalence and trends in obesity among US adults, 1999-2000. | Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L Johnson | JAMA | 2002 | 12365955 | Yes |
2911 | 1096 | 1096.0 | 22.41 | 22.4 | Primary response genes induced by growth factors and tumor promoters. | H R Herschman | Annu Rev Biochem | 1991 | 1883198 | No |
2912 | 1096 | 1096.0 | 37.42 | 37.4 | Selective attention and the organization of visual information. | J Duncan | J Exp Psychol Gen | 1984 | 6240521 | Yes |
2913 | 1096 | 1096.0 | 0.0 | 0.0 | The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. | J Vague | Am J Clin Nutr | 1956 | 13282851 | Yes |
2914 | 2192 | 1096.0 | 52.81 | 26.4 | Cellular processing of platinum anticancer drugs. | Dong Wang, Stephen J Lippard | Nat Rev Drug Discov | 2005 | 15789122 | No |
2915 | 3288 | 1096.0 | 84.01 | 28.0 | Evolution and functions of long noncoding RNAs. | Chris P Ponting, Peter L Oliver, Wolf Reik | Cell | 2009 | 19239885 | No |
2916 | 2191 | 1095.5 | 82.87 | 41.4 | Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. | H Esterbauer, K H Cheeseman | Methods Enzymol | 1990 | 2233308 | Yes |
2917 | 2191 | 1095.5 | 0.0 | 0.0 | A revision of the Schoenheimer-Sperry method for cholesterol determination. | W M Sperry, M Webb | J Biol Chem | 1950 | 14794694 | Yes |
2918 | 2191 | 1095.5 | 47.67 | 23.8 | NF-kappaB: linking inflammation and immunity to cancer development and progression. | Michael Karin, Florian R Greten | Nat Rev Immunol | 2005 | 16175180 | No |
2919 | 1095 | 1095.0 | 39.5 | 39.5 | Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. | J N Wasserheit | Sex Transm Dis | 1992 | 1595015 | No |
2920 | 1095 | 1095.0 | 23.13 | 23.1 | Apoptosis in neurodegenerative disorders. | M P Mattson | Nat Rev Mol Cell Biol | 2000 | 11253364 | No |
2921 | 2190 | 1095.0 | 53.1 | 26.6 | Quorum sensing in bacteria. | M B Miller, B L Bassler | Annu Rev Microbiol | 2001 | 11544353 | No |
2922 | 1095 | 1095.0 | 0.0 | 0.0 | A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. | M G Buonocore | J Dent Res | 1955 | 13271655 | Yes |
2923 | 1095 | 1095.0 | 0.0 | 0.0 | Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins. | R D Owen | Science | 1945 | 17755278 | Yes |
2924 | 1095 | 1095.0 | 0.0 | 0.0 | A Protection Motivation Theory of Fear Appeals and Attitude Change1. | Ronald W Rogers | J Psychol | 1975 | 28136248 | Yes |
2925 | 2189 | 1094.5 | 71.65 | 35.8 | Modeling and comparison of dissolution profiles. | P Costa, J M Sousa Lobo | Eur J Pharm Sci | 2001 | 11297896 | No |
2926 | 1094 | 1094.0 | 0.0 | 0.0 | Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. | K Satoh | Clin Chim Acta | 1978 | 719890 | Yes |
2927 | 1094 | 1094.0 | 31.93 | 31.9 | The effects of stressful life events on depression. | R C Kessler | Annu Rev Psychol | 1997 | 9046559 | No |
2928 | 1094 | 1094.0 | 21.29 | 21.3 | Regulation of phosphoinositide-specific phospholipase C. | S G Rhee | Annu Rev Biochem | 2001 | 11395409 | No |
2929 | 1094 | 1094.0 | 27.42 | 27.4 | Optical microcavities. | Kerry J Vahala | Nature | 2003 | 12917698 | Yes |
2930 | 1094 | 1094.0 | 27.49 | 27.5 | Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. | R Balfour Sartor | Nat Clin Pract Gastroenterol Hepatol | 2006 | 16819502 | No |
2931 | 1094 | 1094.0 | 27.6 | 27.6 | Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. | Hiroshi Takayanagi | Nat Rev Immunol | 2007 | 17380158 | No |
2932 | 2187 | 1093.5 | 77.16 | 38.6 | The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. | G P Chrousos, P W Gold | JAMA | 1992 | 1538563 | No |
2933 | 1093 | 1093.0 | 42.13 | 42.1 | The role of endothelium in the responses of vascular smooth muscle to drugs. | R F Furchgott | Annu Rev Pharmacol Toxicol | 1984 | 6203480 | No |
2934 | 3279 | 1093.0 | 108.47 | 36.2 | Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. | B K Matuszewski, M L Constanzer, C M Chavez-Eng | Anal Chem | 2003 | 12964746 | Yes |
2935 | 2185 | 1092.5 | 0.0 | 0.0 | Micromethod for the direct determination of serum triglycerides. | E Van Handel, D B Zilversmit | J Lab Clin Med | 1957 | 13439279 | Yes |
2936 | 2183 | 1091.5 | 102.74 | 51.4 | Alginate: properties and biomedical applications. | Kuen Yong Lee, David J Mooney | Prog Polym Sci | 2012 | 22125349 | Yes |
2937 | 3271 | 1090.3 | 72.02 | 24.0 | A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. | M Serrano, G J Hannon, D Beach | Nature | 1993 | 8259215 | Yes |
2938 | 1090 | 1090.0 | 23.15 | 23.1 | A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. | J Milbrandt | Science | 1987 | 3672127 | Yes |
2939 | 1090 | 1090.0 | 24.59 | 24.6 | The enzymes, regulation, and genetics of bile acid synthesis. | David W Russell | Annu Rev Biochem | 2003 | 12543708 | No |
2940 | 1090 | 1090.0 | 33.29 | 33.3 | Water as an active constituent in cell biology. | Philip Ball | Chem Rev | 2008 | 18095715 | No |
2941 | 1090 | 1090.0 | 40.69 | 40.7 | Synopsis of some recent tactical application of bioisosteres in drug design. | Nicholas A Meanwell | J Med Chem | 2011 | 21413808 | Yes |
2942 | 1090 | 1090.0 | 50.08 | 50.1 | α-band oscillations, attention, and controlled access to stored information. | Wolfgang Klimesch | Trends Cogn Sci | 2012 | 23141428 | No |
2943 | 1089 | 1089.0 | 23.03 | 23.0 | T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. | R H Schwartz | Annu Rev Immunol | 1985 | 2415139 | No |
2944 | 1089 | 1089.0 | 21.8 | 21.8 | Cytokine receptor signalling. | J N Ihle | Nature | 1995 | 7566171 | No |
2945 | 1089 | 1089.0 | 34.07 | 34.1 | Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. | M E Bouton | Psychol Bull | 1993 | 8346330 | No |
2946 | 1089 | 1089.0 | 0.0 | 0.0 | Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. | R M Berne | Am J Physiol | 1963 | 13971060 | Yes |
2947 | 1089 | 1089.0 | 0.0 | 0.0 | The purine and pyrimidine composition of deoxypentose nucleic acids. | G R Wyatt | Biochem J | 1951 | 14838906 | Yes |
2948 | 4355 | 1088.8 | 130.28 | 32.6 | Toxic potential of materials at the nanolevel. | Andre Nel, Tian Xia, Lutz Mädler, Ning Li | Science | 2006 | 16456071 | No |
2949 | 2177 | 1088.5 | 42.18 | 21.1 | Dynamic instability of microtubule growth. | T Mitchison, M Kirschner | Nature | 1984 | 6504138 | Yes |
2950 | 1088 | 1088.0 | 31.79 | 31.8 | A Wilcoxon-type test for trend. | J Cuzick | Stat Med | 1985 | 3992076 | Yes |
2951 | 1088 | 1088.0 | 34.48 | 34.5 | Strategies of antioxidant defense. | H Sies | Eur J Biochem | 1993 | 7688300 | No |
2952 | 6522 | 1087.0 | 223.7 | 37.3 | Antioxidant activity applying an improved ABTS radical cation decolorization assay. | R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-Evans | Free Radic Biol Med | 1999 | 10381194 | Yes |
2953 | 2174 | 1087.0 | 54.92 | 27.5 | C-reactive protein: a critical update. | Mark B Pepys, Gideon M Hirschfield | J Clin Invest | 2003 | 12813013 | No |
2954 | 1087 | 1087.0 | 33.18 | 33.2 | The Hospital Anxiety And Depression Scale. | R Philip Snaith | Health Qual Life Outcomes | 2003 | 12914662 | Yes |
2955 | 1087 | 1087.0 | 87.74 | 87.7 | Understanding Bland Altman analysis. | Davide Giavarina | Biochem Med (Zagreb) | 2015 | 26110027 | No |
2956 | 1087 | 1087.0 | 71.85 | 71.8 | Abiotic Stress Signaling and Responses in Plants. | Jian-Kang Zhu | Cell | 2016 | 27716505 | No |
2957 | 1086 | 1086.0 | 0.0 | 0.0 | Corticosteroids and lymphoid cells. | H N Claman | N Engl J Med | 1972 | 5043524 | Yes |
2958 | 1086 | 1086.0 | 32.53 | 32.5 | Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. | M J Gasson | J Bacteriol | 1983 | 6403500 | Yes |
2959 | 1086 | 1086.0 | 38.76 | 38.8 | Apoptosis in cancer: from pathogenesis to treatment. | Rebecca S Y Wong | J Exp Clin Cancer Res | 2011 | 21943236 | No |
2960 | 1085 | 1085.0 | 26.16 | 26.2 | Molecular drive: a cohesive mode of species evolution. | G Dover | Nature | 1982 | 7110332 | Yes |
2961 | 1085 | 1085.0 | 29.74 | 29.7 | Functionalized acenes and heteroacenes for organic electronics. | John E Anthony | Chem Rev | 2006 | 17165682 | Yes |
2962 | 1085 | 1085.0 | 0.0 | 0.0 | Aniline hydrogen phthalate as a spraying reagent for chromatography of sugars. | S M Partridge | Nature | 1949 | 18140444 | Yes |
2963 | 1085 | 1085.0 | 0.0 | 0.0 | Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. | P B Medawar | Br J Exp Pathol | 1948 | 18865105 | Yes |
2964 | 2170 | 1085.0 | 50.46 | 25.2 | The canonical Notch signaling pathway: unfolding the activation mechanism. | Raphael Kopan, Maria Xenia G Ilagan | Cell | 2009 | 19379690 | No |
2965 | 2169 | 1084.5 | 0.0 | 0.0 | Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. | A Warshel, M Levitt | J Mol Biol | 1976 | 985660 | Yes |
2966 | 3253 | 1084.3 | 83.87 | 28.0 | Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. | Y Zhang, M Brady, S Smith | IEEE Trans Med Imaging | 2001 | 11293691 | Yes |
2967 | 1084 | 1084.0 | 46.17 | 46.2 | A spreading-activation theory of retrieval in sentence production. | G S Dell | Psychol Rev | 1986 | 3749399 | Yes |
2968 | 1084 | 1084.0 | 37.53 | 37.5 | beta-Lactamases in laboratory and clinical resistance. | D M Livermore | Clin Microbiol Rev | 1995 | 8665470 | No |
2969 | 1084 | 1084.0 | 22.08 | 22.1 | A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. | Xuemei Chen | Science | 2004 | 12893888 | Yes |
2970 | 2168 | 1084.0 | 48.91 | 24.5 | Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. | S W Hell, J Wichmann | Opt Lett | 1994 | 19844443 | Yes |
2971 | 2166 | 1083.0 | 43.87 | 21.9 | RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. | M B Shapiro, P Senapathy | Nucleic Acids Res | 1987 | 3658675 | Yes |
2972 | 1083 | 1083.0 | 32.24 | 32.2 | Cholesterol and the cell membrane. | P L Yeagle | Biochim Biophys Acta | 1985 | 3904832 | No |
2973 | 1083 | 1083.0 | 30.32 | 30.3 | Venous thrombosis: a multicausal disease. | F R Rosendaal | Lancet | 1999 | 10209995 | No |
2974 | 1083 | 1083.0 | 0.0 | 0.0 | Cleavage of the haem-protein link by acid methylethylketone. | F W Teale | Biochim Biophys Acta | 1959 | 13837237 | Yes |
2975 | 3249 | 1083.0 | 89.97 | 30.0 | Bacterial biofilms: from the natural environment to infectious diseases. | Luanne Hall-Stoodley, J William Costerton, Paul Stoodley | Nat Rev Microbiol | 2004 | 15040259 | No |
2976 | 1083 | 1083.0 | 36.93 | 36.9 | Socioeconomic status and obesity. | Lindsay McLaren | Epidemiol Rev | 2007 | 17478442 | No |
2977 | 2166 | 1083.0 | 64.31 | 32.2 | Integrins in cancer: biological implications and therapeutic opportunities. | Jay S Desgrosellier, David A Cheresh | Nat Rev Cancer | 2010 | 20029421 | No |
2978 | 1082 | 1082.0 | 0.0 | 0.0 | A comparison of canal preparations in straight and curved root canals. | S W Schneider | Oral Surg Oral Med Oral Pathol | 1971 | 5284110 | Yes |
2979 | 1082 | 1082.0 | 43.75 | 43.8 | Freezing of living cells: mechanisms and implications. | P Mazur | Am J Physiol | 1984 | 6383068 | No |
2980 | 1082 | 1082.0 | 20.34 | 20.3 | The development of neural stem cells. | S Temple | Nature | 2001 | 11689956 | No |
2981 | 4328 | 1082.0 | 125.39 | 31.3 | Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. | Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S Vasan | Stat Med | 2008 | 17569110 | Yes |
2982 | 1082 | 1082.0 | 36.45 | 36.5 | Persister cells. | Kim Lewis | Annu Rev Microbiol | 2010 | 20528688 | No |
2983 | 1081 | 1081.0 | 27.86 | 27.9 | Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. | M J Berridge | Biochem J | 1983 | 6309155 | Yes |
2984 | 1081 | 1081.0 | 28.69 | 28.7 | Disorders of iron metabolism. | N C Andrews | N Engl J Med | 1999 | 10607817 | No |
2985 | 1081 | 1081.0 | 0.0 | 0.0 | The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs. | M Vogt | J Physiol | 1954 | 13152692 | Yes |
2986 | 1081 | 1081.0 | 22.4 | 22.4 | Inferences, questions and possibilities in Toll-like receptor signalling. | Bruce Beutler | Nature | 2004 | 15241424 | No |
2987 | 2161 | 1080.5 | 45.82 | 22.9 | p53: puzzle and paradigm. | L J Ko, C Prives | Genes Dev | 1996 | 8654922 | No |
2988 | 2161 | 1080.5 | 69.03 | 34.5 | Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. | S Geman, D Geman | IEEE Trans Pattern Anal Mach Intell | 1984 | 22499653 | Yes |
2989 | 2159 | 1079.5 | 64.63 | 32.3 | Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. | P Brugada, J Brugada | J Am Coll Cardiol | 1992 | 1309182 | Yes |
2990 | 1079 | 1079.0 | 27.8 | 27.8 | Selectins: interpreters of cell-specific carbohydrate information during inflammation. | L A Lasky | Science | 1992 | 1439808 | No |
2991 | 1079 | 1079.0 | 42.07 | 42.1 | A new international staging system for lung cancer. | C F Mountain | Chest | 1986 | 3514171 | No |
2992 | 1079 | 1079.0 | 34.39 | 34.4 | The oxidation hypothesis of atherosclerosis. | J L Witztum | Lancet | 1994 | 7916078 | No |
2993 | 1079 | 1079.0 | 21.73 | 21.7 | Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. | A S Baldwin | J Clin Invest | 2001 | 11160144 | No |
2994 | 4316 | 1079.0 | 88.14 | 22.0 | Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. | L Alexopoulou, A C Holt, R Medzhitov, R A Flavell | Nature | 2001 | 11607032 | Yes |
2995 | 1079 | 1079.0 | 26.14 | 26.1 | Evaluating medication effects outside of clinical trials: new-user designs. | Wayne A Ray | Am J Epidemiol | 2003 | 14585769 | Yes |
2996 | 1078 | 1078.0 | 0.0 | 0.0 | A kinetic photometric method for serum gamma-glutamyl transpeptidase. | G Szasz | Clin Chem | 1969 | 5773262 | Yes |
2997 | 1078 | 1078.0 | 25.31 | 25.3 | G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. | Jeffery T Davis | Angew Chem Int Ed Engl | 2004 | 14755695 | No |
2998 | 6468 | 1078.0 | 201.97 | 33.7 | Free radicals and antioxidants in normal physiological functions and human disease. | Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua Telser | Int J Biochem Cell Biol | 2007 | 16978905 | No |
2999 | 2156 | 1078.0 | 73.61 | 36.8 | Plasmonics for improved photovoltaic devices. | Harry A Atwater, Albert Polman | Nat Mater | 2010 | 20168344 | Yes |
3000 | 2155 | 1077.5 | 67.52 | 33.8 | A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. | A Ennaceur, J Delacour | Behav Brain Res | 1988 | 3228475 | Yes |
3001 | 1077 | 1077.0 | 37.82 | 37.8 | Multiple organ failure. Pathophysiology and potential future therapy. | E A Deitch | Ann Surg | 1992 | 1503516 | No |
3002 | 1077 | 1077.0 | 31.03 | 31.0 | Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. | T Feizi | Nature | 1985 | 2579340 | Yes |
3003 | 1077 | 1077.0 | 32.68 | 32.7 | A human model of gastric carcinogenesis. | P Correa | Cancer Res | 1988 | 3288329 | No |
3004 | 1077 | 1077.0 | 25.29 | 25.3 | Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. | H J Dargie | Lancet | 2001 | 11356434 | Yes |
3005 | 3231 | 1077.0 | 76.07 | 25.4 | Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. | Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen | Science | 2005 | 15831717 | Yes |
3006 | 2153 | 1076.5 | 70.93 | 35.5 | Chronic hepatitis B: update 2009. | Anna S F Lok, Brian J McMahon | Hepatology | 2009 | 19714720 | Yes |
3007 | 2152 | 1076.0 | 0.0 | 0.0 | Peroxidase-labeled antibody. A new method of conjugation. | P K Nakane, A Kawaoi | J Histochem Cytochem | 1974 | 4443551 | Yes |
3008 | 1076 | 1076.0 | 0.0 | 0.0 | A teacher rating scale for use in drug studies with children. | C K Conners | Am J Psychiatry | 1969 | 4900822 | Yes |
3009 | 1076 | 1076.0 | 0.0 | 0.0 | Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities. | F Fonnum | Biochem J | 1969 | 4982085 | Yes |
3010 | 2152 | 1076.0 | 66.52 | 33.3 | 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. | A Poland, J C Knutson | Annu Rev Pharmacol Toxicol | 1982 | 6282188 | No |
3011 | 1076 | 1076.0 | 33.62 | 33.6 | The somatic marker hypothesis and the possible functions of the prefrontal cortex. | A R Damasio | Philos Trans R Soc Lond B Biol Sci | 1996 | 8941953 | No |
3012 | 1076 | 1076.0 | 23.96 | 24.0 | Assortative mixing in networks. | M E J Newman | Phys Rev Lett | 2002 | 12443515 | Yes |
3013 | 2151 | 1075.5 | 57.94 | 29.0 | Oxidative stress, caloric restriction, and aging. | R S Sohal, R Weindruch | Science | 1996 | 8658196 | No |
3014 | 1075 | 1075.0 | 32.87 | 32.9 | What is synergy? | M C Berenbaum | Pharmacol Rev | 1989 | 2692037 | No |
3015 | 2150 | 1075.0 | 73.37 | 36.7 | Physiological parameters in laboratory animals and humans. | B Davies, T Morris | Pharm Res | 1993 | 8378254 | No |
3016 | 2150 | 1075.0 | 58.61 | 29.3 | Hydrogels for tissue engineering: scaffold design variables and applications. | Jeanie L Drury, David J Mooney | Biomaterials | 2003 | 12922147 | No |
3017 | 2149 | 1074.5 | 49.53 | 24.8 | Defining the role of mTOR in cancer. | David A Guertin, David M Sabatini | Cancer Cell | 2007 | 17613433 | No |
3018 | 1074 | 1074.0 | 23.58 | 23.6 | Fluorescence spectroscopy of single biomolecules. | S Weiss | Science | 1999 | 10073925 | No |
3019 | 1074 | 1074.0 | 21.4 | 21.4 | The power and the promise of DNA methylation markers. | Peter W Laird | Nat Rev Cancer | 2003 | 12671664 | No |
3020 | 1074 | 1074.0 | 0.0 | 0.0 | Asymptomatic infections of the urinary tract. | E H Kass | Trans Assoc Am Physicians | 1956 | 13380946 | Yes |
3021 | 2148 | 1074.0 | 60.43 | 30.2 | EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. | Stefan Stoll, Arthur Schweiger | J Magn Reson | 2006 | 16188474 | Yes |
3022 | 2148 | 1074.0 | 60.6 | 30.3 | Biology of incretins: GLP-1 and GIP. | Laurie L Baggio, Daniel J Drucker | Gastroenterology | 2007 | 17498508 | No |
3023 | 1074 | 1074.0 | 31.79 | 31.8 | Infection in solid-organ transplant recipients. | Jay A Fishman | N Engl J Med | 2007 | 18094380 | No |
3024 | 2147 | 1073.5 | 74.04 | 37.0 | Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. | A E Czeizel, I Dudás | N Engl J Med | 1992 | 1307234 | Yes |
3025 | 2147 | 1073.5 | 48.68 | 24.3 | Cell cycle control and cancer. | L H Hartwell, M B Kastan | Science | 1994 | 7997877 | No |
3026 | 6440 | 1073.3 | 142.51 | 23.8 | Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. | D A Melton, P A Krieg, M R Rebagliati, T Maniatis, K Zinn, M R Green | Nucleic Acids Res | 1984 | 6091052 | Yes |
3027 | 2146 | 1073.0 | 45.43 | 22.7 | Sequence logos: a new way to display consensus sequences. | T D Schneider, R M Stephens | Nucleic Acids Res | 1990 | 2172928 | Yes |
3028 | 2146 | 1073.0 | 47.83 | 23.9 | Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. | T Hunter, J Pines | Cell | 1994 | 7954824 | No |
3029 | 1073 | 1073.0 | 31.56 | 31.6 | The pollution of the marine environment by plastic debris: a review. | José G B Derraik | Mar Pollut Bull | 2002 | 12405208 | No |
3030 | 2145 | 1072.5 | 0.0 | 0.0 | T antigen is bound to a host protein in SV40-transformed cells. | D P Lane, L V Crawford | Nature | 1979 | 218111 | Yes |
3031 | 2145 | 1072.5 | 75.38 | 37.7 | Pharmaceuticals and personal care products in the environment: agents of subtle change? | C G Daughton, T A Ternes | Environ Health Perspect | 1999 | 10592150 | No |
3032 | 1072 | 1072.0 | 29.82 | 29.8 | Aging, energy, and oxidative stress in neurodegenerative diseases. | M F Beal | Ann Neurol | 1995 | 7668820 | No |
3033 | 2144 | 1072.0 | 55.65 | 27.8 | Statistical tests of neutrality of mutations. | Y X Fu, W H Li | Genetics | 1993 | 8454210 | Yes |
3034 | 2144 | 1072.0 | 0.0 | 0.0 | Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques. | P Gold, S O Freedman | J Exp Med | 1965 | 14270243 | Yes |
3035 | 2143 | 1071.5 | 65.19 | 32.6 | Physiological time-series analysis using approximate entropy and sample entropy. | J S Richman, J R Moorman | Am J Physiol Heart Circ Physiol | 2000 | 10843903 | Yes |
3036 | 2143 | 1071.5 | 42.86 | 21.4 | Rho GTPases: biochemistry and biology. | Aron B Jaffe, Alan Hall | Annu Rev Cell Dev Biol | 2005 | 16212495 | No |
3037 | 1071 | 1071.0 | 34.39 | 34.4 | Relations between the statistics of natural images and the response properties of cortical cells. | D J Field | J Opt Soc Am A | 1987 | 3430225 | Yes |
3038 | 1071 | 1071.0 | 25.65 | 25.6 | Neurons with graded response have collective computational properties like those of two-state neurons. | J J Hopfield | Proc Natl Acad Sci U S A | 1984 | 6587342 | Yes |
3039 | 1071 | 1071.0 | 23.63 | 23.6 | PHD: predicting one-dimensional protein structure by profile-based neural networks. | B Rost | Methods Enzymol | 1996 | 8743704 | Yes |
3040 | 1071 | 1071.0 | 25.19 | 25.2 | Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. | Michael J Sanderson | Mol Biol Evol | 2002 | 11752195 | Yes |
3041 | 1071 | 1071.0 | 0.0 | 0.0 | A New Serum Type System In Man--The Lp System. | K Berg | Acta Pathol Microbiol Scand | 1963 | 14064818 | Yes |
3042 | 2142 | 1071.0 | 51.82 | 25.9 | Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. | Jing Yang, Robert A Weinberg | Dev Cell | 2008 | 18539112 | No |
3043 | 4281 | 1070.2 | 0.0 | 0.0 | Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. | L A Papile, J Burstein, R Burstein, H Koffler | J Pediatr | 1978 | 305471 | Yes |
3044 | 4281 | 1070.2 | 0.0 | 0.0 | The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. | P J Randle, P B Garland, C N Hales, E A Newsholme | Lancet | 1963 | 13990765 | Yes |
3045 | 2140 | 1070.0 | 68.63 | 34.3 | Glutamate and the pathophysiology of hypoxic--ischemic brain damage. | S M Rothman, J W Olney | Ann Neurol | 1986 | 2421636 | No |
3046 | 1070 | 1070.0 | 26.48 | 26.5 | Plant salt tolerance. | J K Zhu | Trends Plant Sci | 2001 | 11173290 | Yes |
3047 | 1070 | 1070.0 | 21.31 | 21.3 | The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. | Y Yarden | Eur J Cancer | 2001 | 11597398 | No |
3048 | 2140 | 1070.0 | 58.93 | 29.5 | Morris water maze: procedures for assessing spatial and related forms of learning and memory. | Charles V Vorhees, Michael T Williams | Nat Protoc | 2006 | 17406317 | Yes |
3049 | 1070 | 1070.0 | 38.22 | 38.2 | The epidemiology of adult obstructive sleep apnea. | Naresh M Punjabi | Proc Am Thorac Soc | 2008 | 18250205 | No |
3050 | 4279 | 1069.8 | 142.74 | 35.7 | The cholinergic hypothesis of geriatric memory dysfunction. | R T Bartus, R L Dean, B Beer, A S Lippa | Science | 1982 | 7046051 | No |
3051 | 3208 | 1069.3 | 158.17 | 52.7 | Scoping studies: advancing the methodology. | Danielle Levac, Heather Colquhoun, Kelly K O'Brien | Implement Sci | 2010 | 20854677 | Yes |
3052 | 1069 | 1069.0 | 42.15 | 42.1 | Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. | J T Daugirdas | J Am Soc Nephrol | 1993 | 8305648 | Yes |
3053 | 2138 | 1069.0 | 50.94 | 25.5 | Shape-controlled synthesis of gold and silver nanoparticles. | Yugang Sun, Younan Xia | Science | 2002 | 12481134 | Yes |
3054 | 5344 | 1068.8 | 268.16 | 53.6 | Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. | N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W Stitt | J Rheumatol | 1988 | 3068365 | Yes |
3055 | 2137 | 1068.5 | 52.87 | 26.4 | Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. | Josep M Llovet, Jordi Bruix | Hepatology | 2003 | 12540794 | No |
3056 | 1068 | 1068.0 | 32.33 | 32.3 | Analyzing the mosaic structure of genes. | J M Smith | J Mol Evol | 1992 | 1556748 | No |
3057 | 1068 | 1068.0 | 27.05 | 27.1 | The Trk family of neurotrophin receptors. | M Barbacid | J Neurobiol | 1994 | 7852993 | No |
3058 | 1068 | 1068.0 | 18.92 | 18.9 | Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. | M S Wold | Annu Rev Biochem | 1997 | 9242902 | No |
3059 | 2136 | 1068.0 | 56.49 | 28.2 | Protein oxidation in aging, disease, and oxidative stress. | B S Berlett, E R Stadtman | J Biol Chem | 1997 | 9252331 | No |
3060 | 1068 | 1068.0 | 24.47 | 24.5 | The myofibroblast in wound healing and fibrocontractive diseases. | G Gabbiani | J Pathol | 2003 | 12845617 | No |
3061 | 1068 | 1068.0 | 40.24 | 40.2 | AmpC beta-lactamases. | George A Jacoby | Clin Microbiol Rev | 2009 | 19136439 | No |
3062 | 2135 | 1067.5 | 65.86 | 32.9 | Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. | Xiaobo Chen, Samuel S Mao | Chem Rev | 2007 | 17590053 | Yes |
3063 | 1067 | 1067.0 | 36.93 | 36.9 | How stigma interferes with mental health care. | Patrick Corrigan | Am Psychol | 2004 | 15491256 | Yes |
3064 | 1067 | 1067.0 | 25.66 | 25.7 | Next-generation DNA sequencing methods. | Elaine R Mardis | Annu Rev Genomics Hum Genet | 2008 | 18576944 | No |
3065 | 2133 | 1066.5 | 53.3 | 26.6 | Cell cycle, CDKs and cancer: a changing paradigm. | Marcos Malumbres, Mariano Barbacid | Nat Rev Cancer | 2009 | 19238148 | No |
3066 | 2132 | 1066.0 | 0.0 | 0.0 | Binding of soluble form of fibroblast surface protein, fibronectin, to collagen. | E Engvall, E Ruoslahti | Int J Cancer | 1977 | 903179 | Yes |
3067 | 1066 | 1066.0 | 0.0 | 0.0 | Statistical quality control and routine data processing for radioimmunoassays and immunoradiometric assays. | D Rodbard | Clin Chem | 1974 | 4370388 | No |
3068 | 2132 | 1066.0 | 0.0 | 0.0 | Calcium-dependent bacteriophage DNA infection. | M Mandel, A Higa | J Mol Biol | 1970 | 4922220 | Yes |
3069 | 1066 | 1066.0 | 0.0 | 0.0 | Time-dependent processes in memory storage. | J L McGaugh | Science | 1966 | 5917768 | Yes |
3070 | 1066 | 1066.0 | 19.25 | 19.2 | Regulatory T cells in autoimmmunity*. | E M Shevach | Annu Rev Immunol | 2000 | 10837065 | No |
3071 | 2131 | 1065.5 | 53.15 | 26.6 | Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. | M E Feder, G E Hofmann | Annu Rev Physiol | 1999 | 10099689 | No |
3072 | 3196 | 1065.3 | 86.81 | 28.9 | Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. | R Schreck, P Rieber, P A Baeuerle | EMBO J | 1991 | 2065663 | Yes |
3073 | 1065 | 1065.0 | 0.0 | 0.0 | Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. | P Stastny | N Engl J Med | 1978 | 147420 | Yes |
3074 | 2130 | 1065.0 | 62.31 | 31.2 | The acute phase response. | H Baumann, J Gauldie | Immunol Today | 1994 | 7512342 | No |
3075 | 5325 | 1065.0 | 114.36 | 22.9 | The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. | J W Harper, G R Adami, N Wei, K Keyomarsi, S J Elledge | Cell | 1993 | 8242751 | Yes |
3076 | 1065 | 1065.0 | 38.16 | 38.2 | Density matrix formulation for quantum renormalization groups. | White | Phys Rev Lett | 1992 | 10046608 | Yes |
3077 | 1065 | 1065.0 | 21.83 | 21.8 | VEGF and the quest for tumour angiogenesis factors. | Napoleone Ferrara | Nat Rev Cancer | 2002 | 12360282 | No |
3078 | 1065 | 1065.0 | 22.62 | 22.6 | Liver regeneration: from myth to mechanism. | Rebecca Taub | Nat Rev Mol Cell Biol | 2004 | 15459664 | No |
3079 | 3193 | 1064.3 | 0.0 | 0.0 | Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. | M Jondal, G Holm, H Wigzell | J Exp Med | 1972 | 4114496 | Yes |
3080 | 1064 | 1064.0 | 25.13 | 25.1 | Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. | S H Kaufmann | Cancer Res | 1989 | 2790800 | Yes |
3081 | 1064 | 1064.0 | 42.69 | 42.7 | Geriatric Depression Scale. | J A Yesavage | Psychopharmacol Bull | 1988 | 3249773 | Yes |
3082 | 2128 | 1064.0 | 49.66 | 24.8 | Esophageal cancer. | Peter C Enzinger, Robert J Mayer | N Engl J Med | 2003 | 14657432 | No |
3083 | 1064 | 1064.0 | 24.1 | 24.1 | Version 1.2 of the Crystallography and NMR system. | Axel T Brunger | Nat Protoc | 2007 | 18007608 | Yes |
3084 | 1064 | 1064.0 | 26.09 | 26.1 | The impact of next-generation sequencing technology on genetics. | Elaine R Mardis | Trends Genet | 2008 | 18262675 | No |
3085 | 6383 | 1063.8 | 163.38 | 27.2 | Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. | S Yusuf, P Sleight, J Pogue, J Bosch, R Davies, G Dagenais | N Engl J Med | 2000 | 10639539 | Yes |
3086 | 2127 | 1063.5 | 44.43 | 22.2 | A survey of telomerase activity in human cancer. | J W Shay, S Bacchetti | Eur J Cancer | 1997 | 9282118 | No |
3087 | 2127 | 1063.5 | 51.1 | 25.6 | Hepatitis C virus infection. | G M Lauer, B D Walker | N Engl J Med | 2001 | 11439948 | No |
3088 | 2126 | 1063.0 | 0.0 | 0.0 | The growth of mouse bone marrow cells in vitro. | T R Bradley, D Metcalf | Aust J Exp Biol Med Sci | 1966 | 4164182 | Yes |
3089 | 1063 | 1063.0 | 25.31 | 25.3 | Selectins and their ligands: current concepts and controversies. | G S Kansas | Blood | 1996 | 8896391 | No |
3090 | 1063 | 1063.0 | 21.53 | 21.5 | Coiled coils: new structures and new functions. | A Lupas | Trends Biochem Sci | 1996 | 8918191 | No |
3091 | 4252 | 1063.0 | 106.81 | 26.7 | C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. | P M Ridker, C H Hennekens, J E Buring, N Rifai | N Engl J Med | 2000 | 10733371 | Yes |
3092 | 2126 | 1063.0 | 65.6 | 32.8 | Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. | Taro Kawai, Shizuo Akira | Immunity | 2011 | 21616434 | No |
3093 | 1062 | 1062.0 | 0.0 | 0.0 | Functional connections between cells as revealed by dye-coupling with a highly fluorescent naphthalimide tracer. | W W Stewart | Cell | 1978 | 688392 | Yes |
3094 | 1062 | 1062.0 | 25.6 | 25.6 | Cells in stress: transcriptional activation of heat shock genes. | R I Morimoto | Science | 1993 | 8451637 | No |
3095 | 1062 | 1062.0 | 25.69 | 25.7 | Aptamers: an emerging class of molecules that rival antibodies in diagnostics. | S D Jayasena | Clin Chem | 1999 | 10471678 | No |
3096 | 1062 | 1062.0 | 36.44 | 36.4 | Checklists for improving rigour in qualitative research: a case of the tail wagging the dog? | R S Barbour | BMJ | 2001 | 11337448 | No |
3097 | 1062 | 1062.0 | 34.28 | 34.3 | Platelet-rich plasma: evidence to support its use. | Robert E Marx | J Oral Maxillofac Surg | 2004 | 15085519 | No |
3098 | 2123 | 1061.5 | 45.52 | 22.8 | Plant pathogens and integrated defence responses to infection. | J L Dangl, J D Jones | Nature | 2001 | 11459065 | No |
3099 | 1061 | 1061.0 | 26.05 | 26.1 | A tension-based theory of morphogenesis and compact wiring in the central nervous system. | D C Van Essen | Nature | 1997 | 9002514 | Yes |
3100 | 1061 | 1061.0 | 28.6 | 28.6 | The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. | R A Jain | Biomaterials | 2000 | 11055295 | No |
3101 | 1061 | 1061.0 | 24.84 | 24.8 | Current concepts of the pathogenesis of the acute coronary syndromes. | P Libby | Circulation | 2001 | 11457759 | No |
3102 | 1061 | 1061.0 | 25.14 | 25.1 | The tumor microenvironment and its role in promoting tumor growth. | T L Whiteside | Oncogene | 2008 | 18836471 | No |
3103 | 2121 | 1060.5 | 45.36 | 22.7 | Mitogen-activated protein kinase pathways. | M J Robinson, M H Cobb | Curr Opin Cell Biol | 1997 | 9069255 | No |
3104 | 1060 | 1060.0 | 30.32 | 30.3 | Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine. | E M Tan | Adv Immunol | 1982 | 6182766 | No |
3105 | 1060 | 1060.0 | 35.92 | 35.9 | High density lipoprotein metabolism. | S Eisenberg | J Lipid Res | 1984 | 6392459 | No |
3106 | 1060 | 1060.0 | 20.11 | 20.1 | Chronic myeloid leukemia. | C L Sawyers | N Engl J Med | 1999 | 10219069 | No |
3107 | 2120 | 1060.0 | 0.0 | 0.0 | Histochemistry of hepatic phosphatases of a physiologic pH; with special reference to the demonstration of bile canaliculi. | M Wachstein, E Meisel | Am J Clin Pathol | 1957 | 13410831 | Yes |
3108 | 1060 | 1060.0 | 30.34 | 30.3 | Persister cells, dormancy and infectious disease. | Kim Lewis | Nat Rev Microbiol | 2007 | 17143318 | No |
3109 | 1060 | 1060.0 | 28.63 | 28.6 | Recent advances in neuroblastoma. | John M Maris | N Engl J Med | 2010 | 20558371 | No |
3110 | 2119 | 1059.5 | 0.0 | 0.0 | The pathogenesis of atherosclerosis (first of two parts). | R Ross, J A Glomset | N Engl J Med | 1976 | 819830 | No |
3111 | 2119 | 1059.5 | 0.0 | 0.0 | Chronic catheterization of the spinal subarachnoid space. | T L Yaksh, T A Rudy | Physiol Behav | 1976 | 14677603 | Yes |
3112 | 4238 | 1059.5 | 159.84 | 40.0 | Prevalence and trends in obesity among US adults, 1999-2008. | Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R Curtin | JAMA | 2010 | 20071471 | Yes |
3113 | 1059 | 1059.0 | 39.04 | 39.0 | Tumor delivery of macromolecular drugs based on the EPR effect. | Vladimir Torchilin | Adv Drug Deliv Rev | 2011 | 20304019 | No |
3114 | 11649 | 1059.0 | 341.68 | 31.1 | The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. | Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristo | Genome Res | 2010 | 20644199 | Yes |
3115 | 3176 | 1058.7 | 92.93 | 31.0 | Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. | Robert D Schreiber, Lloyd J Old, Mark J Smyth | Science | 2011 | 21436444 | No |
3116 | 2117 | 1058.5 | 45.8 | 22.9 | The Hsp70 and Hsp60 chaperone machines. | B Bukau, A L Horwich | Cell | 1998 | 9476895 | No |
3117 | 2116 | 1058.0 | 53.84 | 26.9 | The protective effects of estrogen on the cardiovascular system. | M E Mendelsohn, R H Karas | N Engl J Med | 1999 | 10362825 | No |
3118 | 2116 | 1058.0 | 0.0 | 0.0 | Use of glucose oxidase, peroxidase, and O-dianisidine in determination of blood and urinary glucose. | A S Huggett, D A Nixon | Lancet | 1957 | 13464070 | Yes |
3119 | 1057 | 1057.0 | 0.0 | 0.0 | Cell lines derived from late embryonic stages of Drosophila melanogaster. | I Schneider | J Embryol Exp Morphol | 1972 | 4625067 | Yes |
3120 | 2113 | 1056.5 | 64.84 | 32.4 | Tumor metastasis: molecular insights and evolving paradigms. | Scott Valastyan, Robert A Weinberg | Cell | 2011 | 22000009 | No |
3121 | 1056 | 1056.0 | 20.44 | 20.4 | At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. | M Kozak | J Mol Biol | 1987 | 3681984 | Yes |
3122 | 1056 | 1056.0 | 0.0 | 0.0 | A colorimetric method for estimating serum triglycerides. | M J Fletcher | Clin Chim Acta | 1968 | 5696963 | Yes |
3123 | 2110 | 1055.0 | 103.54 | 51.8 | Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. | S F Dworkin, L LeResche | J Craniomandib Disord | 1992 | 1298767 | No |
3124 | 2110 | 1055.0 | 76.82 | 38.4 | Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. | A I Basbaum, H L Fields | Annu Rev Neurosci | 1984 | 6143527 | No |
3125 | 1055 | 1055.0 | 39.13 | 39.1 | Coronary physiology. | E O Feigl | Physiol Rev | 1983 | 6296890 | No |
3126 | 1055 | 1055.0 | 23.64 | 23.6 | ECM and cell surface proteolysis: regulating cellular ecology. | Z Werb | Cell | 1997 | 9390552 | No |
3127 | 2110 | 1055.0 | 0.0 | 0.0 | Cortisone in ulcerative colitis; final report on a therapeutic trial. | S C Truelove, L J Witts | Br Med J | 1955 | 13260656 | Yes |
3128 | 1055 | 1055.0 | 0.0 | 0.0 | Fertilizing capacity of spermatozoa deposited into the fallopian tubes. | M C Chang | Nature | 1951 | 14882325 | Yes |
3129 | 1055 | 1055.0 | 31.61 | 31.6 | Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. | P Vestergaard | Osteoporos Int | 2007 | 17068657 | No |
3130 | 1054 | 1054.0 | 21.95 | 21.9 | The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells. | D Metcalf | Nature | 1989 | 2469962 | No |
3131 | 1054 | 1054.0 | 22.47 | 22.5 | The lasso method for variable selection in the Cox model. | R Tibshirani | Stat Med | 1997 | 9044528 | Yes |
3132 | 1054 | 1054.0 | 27.9 | 27.9 | Electrochemiluminescence (ECL). | Mark M Richter | Chem Rev | 2004 | 15186186 | No |
3133 | 1054 | 1054.0 | 27.09 | 27.1 | Tumour necrosis factor and cancer. | Frances Balkwill | Nat Rev Cancer | 2009 | 19343034 | No |
3134 | 1054 | 1054.0 | 37.95 | 38.0 | Thermal properties of graphene and nanostructured carbon materials. | Alexander A Balandin | Nat Mater | 2011 | 21778997 | Yes |
3135 | 1054 | 1054.0 | 34.71 | 34.7 | Deconvoluting the context-dependent role for autophagy in cancer. | Eileen White | Nat Rev Cancer | 2012 | 22534666 | No |
3136 | 2107 | 1053.5 | 0.0 | 0.0 | A microcolorimetric method for the determination of inorganic phosphorus. | H H Taussky, E Shorr | J Biol Chem | 1953 | 13061491 | Yes |
3137 | 1053 | 1053.0 | 24.07 | 24.1 | The inducible transcription activator NF-kappa B: regulation by distinct protein subunits. | P A Baeuerle | Biochim Biophys Acta | 1991 | 2018779 | No |
3138 | 1053 | 1053.0 | 33.28 | 33.3 | MOPAC: a semiempirical molecular orbital program. | J J Stewart | J Comput Aided Mol Des | 1990 | 2197373 | No |
3139 | 1053 | 1053.0 | 25.91 | 25.9 | The granulocyte-macrophage colony-stimulating factors. | D Metcalf | Science | 1985 | 2990035 | No |
3140 | 1053 | 1053.0 | 30.04 | 30.0 | Thermo- and pH-responsive polymers in drug delivery. | Dirk Schmaljohann | Adv Drug Deliv Rev | 2006 | 17125884 | No |
3141 | 1053 | 1053.0 | 42.57 | 42.6 | The role of senescent cells in ageing. | Jan M van Deursen | Nature | 2014 | 24848057 | No |
3142 | 1053 | 1053.0 | 84.63 | 84.6 | Making sense of implementation theories, models and frameworks. | Per Nilsen | Implement Sci | 2015 | 25895742 | Yes |
3143 | 2105 | 1052.5 | 69.06 | 34.5 | Wine, alcohol, platelets, and the French paradox for coronary heart disease. | S Renaud, M de Lorgeril | Lancet | 1992 | 1351198 | Yes |
3144 | 1052 | 1052.0 | 26.28 | 26.3 | The sphingomyelin cycle and the second messenger function of ceramide. | Y A Hannun | J Biol Chem | 1994 | 8106344 | No |
3145 | 1052 | 1052.0 | 31.94 | 31.9 | Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. | P S Tofts | J Magn Reson Imaging | 1997 | 9039598 | No |
3146 | 1052 | 1052.0 | 20.06 | 20.1 | The ubiquitin-proteasome pathway: on protein death and cell life. | A Ciechanover | EMBO J | 1998 | 9857172 | No |
3147 | 1052 | 1052.0 | 46.08 | 46.1 | What is self-rated health and why does it predict mortality? Towards a unified conceptual model. | Marja Jylhä | Soc Sci Med | 2009 | 19520474 | Yes |
3148 | 1051 | 1051.0 | 0.0 | 0.0 | Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. | D L Coleman | Diabetologia | 1978 | 350680 | No |
3149 | 1051 | 1051.0 | 18.43 | 18.4 | Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. | R Rothstein | Methods Enzymol | 1991 | 2005793 | Yes |
3150 | 1051 | 1051.0 | 27.09 | 27.1 | Axonal growth-associated proteins. | J H Skene | Annu Rev Neurosci | 1989 | 2648946 | No |
3151 | 1051 | 1051.0 | 0.0 | 0.0 | The ultrastructural basis of capillary permeability studied with peroxidase as a tracer. | M J Karnovsky | J Cell Biol | 1967 | 6061717 | Yes |
3152 | 1051 | 1051.0 | 29.87 | 29.9 | Disseminating innovations in health care. | Donald M Berwick | JAMA | 2003 | 12697800 | Yes |
3153 | 1051 | 1051.0 | 0.0 | 0.0 | The Permeability Of Capillaries In Various Organs As Determined By Use Of The 'Indicator Diffusion' Method. | C Crone | Acta Physiol Scand | 1963 | 14078649 | Yes |
3154 | 1051 | 1051.0 | 25.61 | 25.6 | Nonaqueous liquid electrolytes for lithium-based rechargeable batteries. | Kang Xu | Chem Rev | 2004 | 15669157 | Yes |
3155 | 1051 | 1051.0 | 40.02 | 40.0 | Volumetric modulated arc therapy: IMRT in a single gantry arc. | Karl Otto | Med Phys | 2008 | 18293586 | Yes |
3156 | 3152 | 1050.7 | 122.66 | 40.9 | Hepatocellular carcinoma. | Alejandro Forner, Josep M Llovet, Jordi Bruix | Lancet | 2012 | 22353262 | No |
3157 | 2101 | 1050.5 | 63.57 | 31.8 | The biochemistry of P-glycoprotein-mediated multidrug resistance. | J A Endicott, V Ling | Annu Rev Biochem | 1989 | 2570548 | No |
3158 | 4201 | 1050.2 | 217.99 | 54.5 | National Institute of Mental Health Diagnostic Interview Schedule. Its history, characteristics, and validity. | L N Robins, J E Helzer, J Croughan, K S Ratcliff | Arch Gen Psychiatry | 1981 | 6260053 | Yes |
3159 | 4200 | 1050.0 | 0.0 | 0.0 | T cell growth factor: parameters of production and a quantitative microassay for activity. | S Gillis, M M Ferm, W Ou, K A Smith | J Immunol | 1978 | 307029 | Yes |
3160 | 1050 | 1050.0 | 29.84 | 29.8 | Mitochondrial genetics: a paradigm for aging and degenerative diseases? | D C Wallace | Science | 1992 | 1533953 | Yes |
3161 | 1050 | 1050.0 | 29.15 | 29.1 | T-cell growth factor. | K A Smith | Immunol Rev | 1980 | 7000676 | No |
3162 | 1050 | 1050.0 | 36.05 | 36.0 | Socioeconomic disadvantage and child development. | V C McLoyd | Am Psychol | 1998 | 9491747 | No |
3163 | 1050 | 1050.0 | 23.62 | 23.6 | Molecular imaging of cancer with positron emission tomography. | Sanjiv Sam Gambhir | Nat Rev Cancer | 2002 | 12209157 | No |
3164 | 1050 | 1050.0 | 0.0 | 0.0 | Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. | G D Winter | Nature | 1962 | 14007593 | Yes |
3165 | 1050 | 1050.0 | 21.34 | 21.3 | Regulation of cadherin-mediated adhesion in morphogenesis. | Barry M Gumbiner | Nat Rev Mol Cell Biol | 2005 | 16025097 | No |
3166 | 1050 | 1050.0 | 22.5 | 22.5 | Protein tyrosine phosphatases: from genes, to function, to disease. | Nicholas K Tonks | Nat Rev Mol Cell Biol | 2006 | 17057753 | No |
3167 | 2099 | 1049.5 | 48.42 | 24.2 | Synaptic activity and the construction of cortical circuits. | L C Katz, C J Shatz | Science | 1996 | 8895456 | No |
3168 | 2099 | 1049.5 | 47.83 | 23.9 | Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. | N Sreerama, R W Woody | Anal Biochem | 2000 | 11112271 | Yes |
3169 | 2099 | 1049.5 | 54.6 | 27.3 | Hydrogels for tissue engineering. | K Y Lee, D J Mooney | Chem Rev | 2001 | 11710233 | No |
3170 | 5246 | 1049.2 | 102.77 | 20.6 | The protein kinase complement of the human genome. | G Manning, D B Whyte, R Martinez, T Hunter, S Sudarsanam | Science | 2002 | 12471243 | No |
3171 | 1049 | 1049.0 | 0.0 | 0.0 | Microtubule formation in vitro in solutions containing low calcium concentrations. | R C Weisenberg | Science | 1972 | 4626639 | Yes |
3172 | 1049 | 1049.0 | 22.1 | 22.1 | mRNA stability in mammalian cells. | J Ross | Microbiol Rev | 1995 | 7565413 | No |
3173 | 1049 | 1049.0 | 19.3 | 19.3 | Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. | Eric C Lai | Nat Genet | 2002 | 11896390 | Yes |
3174 | 1049 | 1049.0 | 46.31 | 46.3 | The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults. | L S Radloff | J Youth Adolesc | 1991 | 24265004 | Yes |
3175 | 3145 | 1048.3 | 103.9 | 34.6 | Qualitative research in health care. Analysing qualitative data. | C Pope, S Ziebland, N Mays | BMJ | 2000 | 10625273 | No |
3176 | 1048 | 1048.0 | 0.0 | 0.0 | The epidemiologic transition. A theory of the epidemiology of population change. | A R Omran | Milbank Mem Fund Q | 1971 | 5155251 | Yes |
3177 | 1048 | 1048.0 | 0.0 | 0.0 | Epidemiology of cancer of the colon and rectum. | D P Burkitt | Cancer | 1971 | 5165022 | Yes |
3178 | 1048 | 1048.0 | 30.25 | 30.2 | Junctional intercellular communication: the cell-to-cell membrane channel. | W R Loewenstein | Physiol Rev | 1981 | 6270711 | No |
3179 | 1048 | 1048.0 | 39.27 | 39.3 | Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants. | R W Bohannon | Age Ageing | 1997 | 9143432 | Yes |
3180 | 1048 | 1048.0 | 20.26 | 20.3 | Biological robustness. | Hiroaki Kitano | Nat Rev Genet | 2004 | 15520792 | No |
3181 | 2095 | 1047.5 | 41.19 | 20.6 | Improved retroviral vectors for gene transfer and expression. | A D Miller, G J Rosman | Biotechniques | 1989 | 2631796 | Yes |
3182 | 1047 | 1047.0 | 40.58 | 40.6 | Infection by verocytotoxin-producing Escherichia coli. | M A Karmali | Clin Microbiol Rev | 1989 | 2644022 | No |
3183 | 1047 | 1047.0 | 29.67 | 29.7 | Determination of total protein. | G L Peterson | Methods Enzymol | 1983 | 6855607 | Yes |
3184 | 2094 | 1047.0 | 57.62 | 28.8 | Chlorophyll fluorescence--a practical guide. | K Maxwell, G N Johnson | J Exp Bot | 2000 | 10938857 | No |
3185 | 1047 | 1047.0 | 24.2 | 24.2 | Toward self-organization and complex matter. | Jean-Marie Lehn | Science | 2002 | 11923524 | Yes |
3186 | 1047 | 1047.0 | 23.85 | 23.9 | Pedigree disequilibrium tests for multilocus haplotypes. | Frank Dudbridge | Genet Epidemiol | 2003 | 12916020 | Yes |
3187 | 1047 | 1047.0 | 0.0 | 0.0 | A production of amino acids under possible primitive earth conditions. | S L Miller | Science | 1953 | 13056598 | Yes |
3188 | 6282 | 1047.0 | 184.52 | 30.8 | Cancer statistics, 2007. | Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Taylor Murray, Jiaquan Xu, Michael J Thun | CA Cancer J Clin | 2007 | 17237035 | Yes |
3189 | 1047 | 1047.0 | 37.18 | 37.2 | Amino acids: metabolism, functions, and nutrition. | Guoyao Wu | Amino Acids | 2009 | 19301095 | No |
3190 | 2093 | 1046.5 | 82.38 | 41.2 | Functional interactions between the gut microbiota and host metabolism. | Valentina Tremaroli, Fredrik Bäckhed | Nature | 2012 | 22972297 | No |
3191 | 2092 | 1046.0 | 0.0 | 0.0 | A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. | J J Sedmak, S E Grossberg | Anal Biochem | 1977 | 68686 | Yes |
3192 | 1046 | 1046.0 | 20.66 | 20.7 | Focal adhesion kinase: the first ten years. | J Thomas Parsons | J Cell Sci | 2003 | 12640026 | No |
3193 | 2091 | 1045.5 | 108.8 | 54.4 | 3D bioprinting of tissues and organs. | Sean V Murphy, Anthony Atala | Nat Biotechnol | 2014 | 25093879 | Yes |
3194 | 1045 | 1045.0 | 0.0 | 0.0 | Protein denaturation. C. Theoretical models for the mechanism of denaturation. | C Tanford | Adv Protein Chem | 1970 | 4912353 | No |
3195 | 1045 | 1045.0 | 27.63 | 27.6 | Neuropathology of Parkinson's disease. | L S Forno | J Neuropathol Exp Neurol | 1996 | 8786384 | No |
3196 | 2090 | 1045.0 | 50.41 | 25.2 | A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. | J N Cohn, G Tognoni | N Engl J Med | 2001 | 11759645 | Yes |
3197 | 2089 | 1044.5 | 54.28 | 27.1 | Principles of bioactive lipid signalling: lessons from sphingolipids. | Yusuf A Hannun, Lina M Obeid | Nat Rev Mol Cell Biol | 2008 | 18216770 | No |
3198 | 1044 | 1044.0 | 0.0 | 0.0 | Lipid peroxidation damage to cell components. | A L Tappel | Fed Proc | 1973 | 4352451 | Yes |
3199 | 1044 | 1044.0 | 0.0 | 0.0 | Mechanisms of lipid peroxide formation in animal tissues. | E D Wills | Biochem J | 1966 | 5964963 | Yes |
3200 | 1044 | 1044.0 | 23.35 | 23.4 | Complement. Second of two parts. | M J Walport | N Engl J Med | 2001 | 11297706 | No |
3201 | 1044 | 1044.0 | 33.12 | 33.1 | Electrochemical glucose biosensors. | Joseph Wang | Chem Rev | 2008 | 18154363 | No |
3202 | 1044 | 1044.0 | 44.3 | 44.3 | The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. | Eleonore Fröhlich | Int J Nanomedicine | 2012 | 23144561 | No |
3203 | 2087 | 1043.5 | 0.0 | 0.0 | Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. | R R Guillard, J H Ryther | Can J Microbiol | 1962 | 13902807 | Yes |
3204 | 1043 | 1043.0 | 27.12 | 27.1 | Two-stage model of memory trace formation: a role for "noisy" brain states. | G Buzsáki | Neuroscience | 1989 | 2687720 | No |
3205 | 2086 | 1043.0 | 74.65 | 37.3 | Social conditions as fundamental causes of disease. | B G Link, J Phelan | J Health Soc Behav | 1995 | 7560851 | No |
3206 | 2086 | 1043.0 | 64.08 | 32.0 | Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. | Aluísio J D Barros, Vânia N Hirakata | BMC Med Res Methodol | 2003 | 14567763 | Yes |
3207 | 2084 | 1042.0 | 77.58 | 38.8 | Fingerprinting genomes using PCR with arbitrary primers. | J Welsh, M McClelland | Nucleic Acids Res | 1990 | 2259619 | Yes |
3208 | 1042 | 1042.0 | 27.04 | 27.0 | Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. | J P Tam | Proc Natl Acad Sci U S A | 1988 | 3399498 | Yes |
3209 | 1042 | 1042.0 | 30.46 | 30.5 | Pathogenetic mechanisms of septic shock. | J E Parrillo | N Engl J Med | 1993 | 8479467 | No |
3210 | 1042 | 1042.0 | 26.46 | 26.5 | Context and behavioral processes in extinction. | Mark E Bouton | Learn Mem | 2004 | 15466298 | No |
3211 | 2083 | 1041.5 | 56.27 | 28.1 | Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. | Subhra K Biswas, Alberto Mantovani | Nat Immunol | 2010 | 20856220 | No |
3212 | 1041 | 1041.0 | 0.0 | 0.0 | Carcinoid tumors. An analysis of 2,837 cases. | J D Godwin | Cancer | 1975 | 1157019 | Yes |
3213 | 1041 | 1041.0 | 27.14 | 27.1 | Comparative physiology of salt and water stress. | R. Munns | Plant Cell Environ | 2002 | 11841667 | Yes |
3214 | 2080 | 1040.0 | 51.41 | 25.7 | Efficient isolation of genes by using antibody probes. | R A Young, R W Davis | Proc Natl Acad Sci U S A | 1983 | 6219389 | Yes |
3215 | 1040 | 1040.0 | 46.67 | 46.7 | Coping theory and research: past, present, and future. | R S Lazarus | Psychosom Med | 1993 | 8346332 | No |
3216 | 1040 | 1040.0 | 32.35 | 32.4 | Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. | P J Basser | NMR Biomed | 1995 | 8739270 | No |
3217 | 1040 | 1040.0 | 30.53 | 30.5 | A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. | Ron Hardman | Environ Health Perspect | 2006 | 16451849 | No |
3218 | 2080 | 1040.0 | 51.36 | 25.7 | Next-generation DNA sequencing. | Jay Shendure, Hanlee Ji | Nat Biotechnol | 2008 | 18846087 | Yes |
3219 | 1040 | 1040.0 | 0.0 | 0.0 | A Serological Differentiation Of Human And Other Groups Of Hemolytic Streptococci. | R C Lancefield | J Exp Med | 1933 | 19870148 | Yes |
3220 | 2079 | 1039.5 | 54.11 | 27.1 | Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. | M S Brown, J L Goldstein | Annu Rev Biochem | 1983 | 6311077 | No |
3221 | 1039 | 1039.0 | 56.85 | 56.9 | The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. | G A Ilizarov | Clin Orthop Relat Res | 1989 | 2910611 | Yes |
3222 | 2078 | 1039.0 | 44.64 | 22.3 | The immunoglobulin superfamily--domains for cell surface recognition. | A F Williams, A N Barclay | Annu Rev Immunol | 1988 | 3289571 | No |
3223 | 1039 | 1039.0 | 0.0 | 0.0 | Cell communication, calcium ion, and cyclic adenosine monophosphate. | H Rasmussen | Science | 1970 | 4318972 | Yes |
3224 | 1039 | 1039.0 | 41.42 | 41.4 | Amyloid deposits and amyloidosis: the beta-fibrilloses (second of two parts). | G G Glenner | N Engl J Med | 1980 | 6990257 | No |
3225 | 1039 | 1039.0 | 30.45 | 30.4 | Muscarinic receptors--characterization, coupling and function. | M P Caulfield | Pharmacol Ther | 1993 | 7504306 | No |
3226 | 1039 | 1039.0 | 19.4 | 19.4 | The Pezcoller lecture: cancer cell cycles revisited. | C J Sherr | Cancer Res | 2000 | 10919634 | No |
3227 | 2078 | 1039.0 | 0.0 | 0.0 | A modified ninhydrin reagent for the photometric determination of amino acids and related compounds. | S Moore, W H Stein | J Biol Chem | 1954 | 13221596 | Yes |
3228 | 1039 | 1039.0 | 0.0 | 0.0 | The effect of emotion on cue utilization and the organization of behavior. | J A Easterbrook | Psychol Rev | 1959 | 13658305 | Yes |
3229 | 1039 | 1039.0 | 0.0 | 0.0 | Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent. | D L Morris | Science | 1948 | 17814729 | Yes |
3230 | 1038 | 1038.0 | 35.05 | 35.0 | Fever: role of pyrogens and cryogens. | M J Kluger | Physiol Rev | 1991 | 1986393 | No |
3231 | 1038 | 1038.0 | 0.0 | 0.0 | Retention of differentiation potentialities during prolonged cultivation of myogenic cells. | D Yaffe | Proc Natl Acad Sci U S A | 1968 | 5245982 | Yes |
3232 | 1038 | 1038.0 | 0.0 | 0.0 | Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. | S Irwin | Psychopharmacologia | 1968 | 5679627 | Yes |
3233 | 2076 | 1038.0 | 0.0 | 0.0 | A simple method for the preparation of 32-P-labelled adenosine triphosphate of high specific activity. | I M Glynn, J B Chappell | Biochem J | 1964 | 5832284 | Yes |
3234 | 3114 | 1038.0 | 88.85 | 29.6 | Methods in mammalian autophagy research. | Noboru Mizushima, Tamotsu Yoshimori, Beth Levine | Cell | 2010 | 20144757 | Yes |
3235 | 3111 | 1037.0 | 112.42 | 37.5 | Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. | P S Walsh, D A Metzger, R Higuchi | Biotechniques | 1991 | 1867860 | Yes |
3236 | 1037 | 1037.0 | 29.78 | 29.8 | Transport of molecules in the tumor interstitium: a review. | R K Jain | Cancer Res | 1987 | 3555767 | No |
3237 | 1037 | 1037.0 | 56.58 | 56.6 | A "rationalized" arcsine transform. | G A Studebaker | J Speech Hear Res | 1985 | 4046587 | Yes |
3238 | 2074 | 1037.0 | 53.9 | 26.9 | Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis. | D C Schwartz, C R Cantor | Cell | 1984 | 6373014 | Yes |
3239 | 1037 | 1037.0 | 37.76 | 37.8 | Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. | M A Lemp | CLAO J | 1995 | 8565190 | No |
3240 | 1037 | 1037.0 | 24.32 | 24.3 | Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis. | Tirion | Phys Rev Lett | 1996 | 10063201 | Yes |
3241 | 1036 | 1036.0 | 0.0 | 0.0 | The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture. | J Cassel | Am J Epidemiol | 1976 | 782233 | No |
3242 | 1036 | 1036.0 | 23.98 | 24.0 | How neutrophils kill microbes. | Anthony W Segal | Annu Rev Immunol | 2005 | 15771570 | No |
3243 | 1036 | 1036.0 | 22.8 | 22.8 | Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. | Sean B Carroll | Cell | 2008 | 18614008 | Yes |
3244 | 5179 | 1035.8 | 161.6 | 32.3 | Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. | Salim Yusuf, Bertram Pitt, Clarence E Davis, William B Hood, Jay N Cohn | N Engl J Med | 1991 | 2057034 | Yes |
3245 | 3107 | 1035.7 | 91.96 | 30.7 | trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. | Salvador Capella-Gutiérrez, José M Silla-Martínez, Toni Gabaldón | Bioinformatics | 2009 | 19505945 | Yes |
3246 | 2071 | 1035.5 | 61.77 | 30.9 | Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. | J M Reul, E R de Kloet | Endocrinology | 1985 | 2998738 | Yes |
3247 | 1035 | 1035.0 | 0.0 | 0.0 | Transformation of yeast by a replicating hybrid plasmid. | J D Beggs | Nature | 1978 | 357984 | Yes |
3248 | 1035 | 1035.0 | 36.5 | 36.5 | A review of psychological risk factors in back and neck pain. | S J Linton | Spine (Phila Pa 1976) | 2000 | 10788861 | No |
3249 | 1035 | 1035.0 | 31.08 | 31.1 | Stronger Brønsted acids. | Takahiko Akiyama | Chem Rev | 2007 | 17983247 | Yes |
3250 | 4139 | 1034.8 | 108.95 | 27.2 | Real time quantitative PCR. | C A Heid, J Stevens, K J Livak, P M Williams | Genome Res | 1996 | 8908518 | Yes |
3251 | 2069 | 1034.5 | 41.55 | 20.8 | A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. | C S Hoffman, F Winston | Gene | 1987 | 3319781 | Yes |
3252 | 2069 | 1034.5 | 51.89 | 25.9 | Modes of resistance to anti-angiogenic therapy. | Gabriele Bergers, Douglas Hanahan | Nat Rev Cancer | 2008 | 18650835 | No |
3253 | 1034 | 1034.0 | 27.87 | 27.9 | Human TH1 and TH2 subsets: doubt no more. | S Romagnani | Immunol Today | 1991 | 1680337 | Yes |
3254 | 1034 | 1034.0 | 25.45 | 25.4 | Quantification of beta-sheet amyloid fibril structures with thioflavin T. | H LeVine | Methods Enzymol | 1999 | 10507030 | Yes |
3255 | 1034 | 1034.0 | 20.33 | 20.3 | Progress in human tumour immunology and immunotherapy. | S A Rosenberg | Nature | 2001 | 11357146 | No |
3256 | 1034 | 1034.0 | 26.46 | 26.5 | Mode of action of membrane active antimicrobial peptides. | Yechiel Shai | Biopolymers | 2002 | 12491537 | No |
3257 | 1034 | 1034.0 | 32.22 | 32.2 | Species concepts and species delimitation. | Kevin De Queiroz | Syst Biol | 2007 | 18027281 | Yes |
3258 | 2067 | 1033.5 | 78.75 | 39.4 | A psychomotor stimulant theory of addiction. | R A Wise, M A Bozarth | Psychol Rev | 1987 | 3317472 | No |
3259 | 3100 | 1033.3 | 147.28 | 49.1 | Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. | F Guillemin, C Bombardier, D Beaton | J Clin Epidemiol | 1993 | 8263569 | No |
3260 | 1033 | 1033.0 | 50.69 | 50.7 | Analysis of Fickian and non-Fickian drug release from polymers. | N A Peppas | Pharm Acta Helv | 1985 | 4011621 | Yes |
3261 | 2066 | 1033.0 | 42.59 | 21.3 | Tumour-cell invasion and migration: diversity and escape mechanisms. | Peter Friedl, Katarina Wolf | Nat Rev Cancer | 2003 | 12724734 | No |
3262 | 3099 | 1033.0 | 74.89 | 25.0 | Photodynamic therapy for cancer. | Dennis E J G J Dolmans, Dai Fukumura, Rakesh K Jain | Nat Rev Cancer | 2003 | 12724736 | No |
3263 | 1033 | 1033.0 | 34.66 | 34.7 | Understanding diagnostic tests 3: Receiver operating characteristic curves. | Anthony K Akobeng | Acta Paediatr | 2007 | 17376185 | No |
3264 | 1032 | 1032.0 | 30.32 | 30.3 | Animal mitochondrial DNA: structure and evolution. | D R Wolstenholme | Int Rev Cytol | 1992 | 1452431 | No |
3265 | 4128 | 1032.0 | 85.0 | 21.2 | Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. | E Schreiber, P Matthias, M M Müller, W Schaffner | Nucleic Acids Res | 1989 | 2771659 | Yes |
3266 | 1032 | 1032.0 | 23.45 | 23.4 | Molecular mechanisms of myocardial remodeling. | B Swynghedauw | Physiol Rev | 1999 | 9922372 | No |
3267 | 3095 | 1031.7 | 100.12 | 33.4 | Health benefits of physical activity: the evidence. | Darren E R Warburton, Crystal Whitney Nicol, Shannon S D Bredin | CMAJ | 2006 | 16534088 | No |
3268 | 1031 | 1031.0 | 0.0 | 0.0 | Surface modulation in cell recognition and cell growth. | G M Edelman | Science | 1976 | 769162 | No |
3269 | 1031 | 1031.0 | 23.59 | 23.6 | Diffraction methods for biological macromolecules. Interactive computer graphics: FRODO. | T A Jones | Methods Enzymol | 1985 | 3841179 | Yes |
3270 | 1031 | 1031.0 | 0.0 | 0.0 | Tests for emotionality in rats and mice: a review. | J Archer | Anim Behav | 1973 | 4578750 | No |
3271 | 1031 | 1031.0 | 24.0 | 24.0 | Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system. | T Ikemura | J Mol Biol | 1981 | 6175758 | Yes |
3272 | 1031 | 1031.0 | 24.2 | 24.2 | The columnar organization of the neocortex. | V B Mountcastle | Brain | 1997 | 9153131 | No |
3273 | 1031 | 1031.0 | 43.41 | 43.4 | Toward terminological, conceptual, and statistical clarity in the study of mediators and moderators: examples from the child-clinical and pediatric psychology literatures. | G N Holmbeck | J Consult Clin Psychol | 1997 | 9256561 | Yes |
3274 | 2062 | 1031.0 | 39.87 | 19.9 | Wnt signaling: a common theme in animal development. | K M Cadigan, R Nusse | Genes Dev | 1997 | 9407023 | No |
3275 | 1031 | 1031.0 | 28.25 | 28.2 | Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. | F P Guengerich | Chem Res Toxicol | 2001 | 11409933 | No |
3276 | 1031 | 1031.0 | 28.48 | 28.5 | The emotional dog and its rational tail: a social intuitionist approach to moral judgment. | J Haidt | Psychol Rev | 2001 | 11699120 | Yes |
3277 | 1031 | 1031.0 | 18.31 | 18.3 | Molecular mechanisms of axon guidance. | Barry J Dickson | Science | 2002 | 12471249 | No |
3278 | 2061 | 1030.5 | 46.27 | 23.1 | Protein-tyrosine kinases. | T Hunter, J A Cooper | Annu Rev Biochem | 1985 | 2992362 | No |
3279 | 1030 | 1030.0 | 26.61 | 26.6 | Automatic quantitation of localized in vivo 1H spectra with LCModel. | S W Provencher | NMR Biomed | 2001 | 11410943 | Yes |
3280 | 1030 | 1030.0 | 0.0 | 0.0 | The stereotaxic method and radiosurgery of the brain. | L Leksell | Acta Chir Scand | 1951 | 14914373 | Yes |
3281 | 1030 | 1030.0 | 33.8 | 33.8 | MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. | Amy E Pasquinelli | Nat Rev Genet | 2012 | 22411466 | No |
3282 | 4118 | 1029.5 | 154.96 | 38.7 | Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. | K F Schulz, I Chalmers, R J Hayes, D G Altman | JAMA | 1995 | 7823387 | Yes |
3283 | 3088 | 1029.3 | 159.55 | 53.2 | Assessing coping strategies: a theoretically based approach. | C S Carver, M F Scheier, J K Weintraub | J Pers Soc Psychol | 1989 | 2926629 | Yes |
3284 | 6175 | 1029.2 | 168.01 | 28.0 | Prediction of coronary heart disease using risk factor categories. | P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B Kannel | Circulation | 1998 | 9603539 | Yes |
3285 | 1029 | 1029.0 | 22.08 | 22.1 | Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. | Z Yang | Mol Biol Evol | 1998 | 9580986 | Yes |
3286 | 1029 | 1029.0 | 19.04 | 19.0 | Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. | W Kolch | Biochem J | 2000 | 11023813 | No |
3287 | 1029 | 1029.0 | 25.15 | 25.1 | P-450 metabolites of arachidonic acid in the control of cardiovascular function. | Richard J Roman | Physiol Rev | 2002 | 11773611 | No |
3288 | 1029 | 1029.0 | 22.66 | 22.7 | Microsatellites: simple sequences with complex evolution. | Hans Ellegren | Nat Rev Genet | 2004 | 15153996 | No |
3289 | 1029 | 1029.0 | 0.0 | 0.0 | Cell deaths in normal vertebrate ontogeny. | A Glucksmann | Biol Rev Camb Philos Soc | 1951 | 24540363 | Yes |
3290 | 3086 | 1028.7 | 0.0 | 0.0 | Therapeutic criteria in rheumatoid arthritis. | O Steinbrocker, C H Traeger, R C Batterman | J Am Med Assoc | 1949 | 18150288 | Yes |
3291 | 1028 | 1028.0 | 33.91 | 33.9 | Peritonectomy procedures. | P H Sugarbaker | Ann Surg | 1995 | 7826158 | Yes |
3292 | 6168 | 1028.0 | 166.56 | 27.8 | An obesity-associated gut microbiome with increased capacity for energy harvest. | Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I Gordon | Nature | 2006 | 17183312 | Yes |
3293 | 2055 | 1027.5 | 53.28 | 26.6 | The regulation and function of c-fos and other immediate early genes in the nervous system. | M Sheng, M E Greenberg | Neuron | 1990 | 1969743 | No |
3294 | 2055 | 1027.5 | 36.84 | 18.4 | Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. | W Gu, R G Roeder | Cell | 1997 | 9288740 | Yes |
3295 | 2055 | 1027.5 | 69.48 | 34.7 | Inflammatory mechanisms in obesity. | Margaret F Gregor, Gökhan S Hotamisligil | Annu Rev Immunol | 2011 | 21219177 | No |
3296 | 3082 | 1027.3 | 80.44 | 26.8 | Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). | R S Spielman, R E McGinnis, W J Ewens | Am J Hum Genet | 1993 | 8447318 | Yes |
3297 | 1027 | 1027.0 | 54.25 | 54.2 | The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. | G A Ilizarov | Clin Orthop Relat Res | 1989 | 2912628 | Yes |
3298 | 1027 | 1027.0 | 0.0 | 0.0 | Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies. | J Ott | Am J Hum Genet | 1974 | 4422075 | Yes |
3299 | 2054 | 1027.0 | 48.65 | 24.3 | Blinded by the Light: The Growing Complexity of p53. | Karen H Vousden, Carol Prives | Cell | 2009 | 19410540 | No |
3300 | 2052 | 1026.0 | 43.61 | 21.8 | Genomic control for association studies. | B Devlin, K Roeder | Biometrics | 1999 | 11315092 | Yes |
3301 | 1026 | 1026.0 | 30.02 | 30.0 | Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. | John W Newcomer | CNS Drugs | 2005 | 15998156 | No |
3302 | 1026 | 1026.0 | 21.26 | 21.3 | Telomeres and human disease: ageing, cancer and beyond. | Maria A Blasco | Nat Rev Genet | 2005 | 16136653 | No |
3303 | 1026 | 1026.0 | 0.0 | 0.0 | Connections of the cerebral cortex; the albino rat; topography of the cortical areas. | W J S Krieg | J Comp Neurol | 1946 | 20982805 | Yes |
3304 | 1025 | 1025.0 | 0.0 | 0.0 | The role of calcium in the release of neurotransmitter substances and hormones. | R P Rubin | Pharmacol Rev | 1970 | 4322219 | No |
3305 | 1025 | 1025.0 | 0.0 | 0.0 | The influence of immunologically committed lymphoid cells on macrophage activity in vivo. | G B Mackaness | J Exp Med | 1969 | 4976110 | Yes |
3306 | 1025 | 1025.0 | 22.92 | 22.9 | Epstein-Barr virus infection. | J I Cohen | N Engl J Med | 2000 | 10944566 | No |
3307 | 1025 | 1025.0 | 28.29 | 28.3 | TNF-mediated inflammatory disease. | J R Bradley | J Pathol | 2008 | 18161752 | No |
3308 | 3072 | 1024.0 | 79.96 | 26.7 | Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions. | M Piotto, V Saudek, V Sklenár | J Biomol NMR | 1992 | 1490109 | Yes |
3309 | 2048 | 1024.0 | 42.37 | 21.2 | IAP family proteins--suppressors of apoptosis. | Q L Deveraux, J C Reed | Genes Dev | 1999 | 9990849 | No |
3310 | 1023 | 1023.0 | 0.0 | 0.0 | Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4332694 | Yes |
3311 | 7161 | 1023.0 | 217.53 | 31.1 | Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. | H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E Marsh | Stroke | 1993 | 7678184 | Yes |
3312 | 1023 | 1023.0 | 28.82 | 28.8 | Synchronization of cortical activity and its putative role in information processing and learning. | W Singer | Annu Rev Physiol | 1993 | 8466179 | No |
3313 | 1023 | 1023.0 | 29.75 | 29.8 | Limbic-cortical dysregulation: a proposed model of depression. | H S Mayberg | J Neuropsychiatry Clin Neurosci | 1997 | 9276848 | No |
3314 | 1023 | 1023.0 | 23.49 | 23.5 | New ideas about atrial fibrillation 50 years on. | Stanley Nattel | Nature | 2002 | 11805846 | No |
3315 | 2045 | 1022.5 | 61.28 | 30.6 | The capacity of visual working memory for features and conjunctions. | S J Luck, E K Vogel | Nature | 1997 | 9384378 | Yes |
3316 | 2045 | 1022.5 | 42.97 | 21.5 | Community structure in social and biological networks. | M Girvan, M E J Newman | Proc Natl Acad Sci U S A | 2002 | 12060727 | No |
3317 | 1022 | 1022.0 | 21.72 | 21.7 | Osmotic stress signaling and osmoadaptation in yeasts. | Stefan Hohmann | Microbiol Mol Biol Rev | 2002 | 12040128 | No |
3318 | 1022 | 1022.0 | 28.34 | 28.3 | Epidemiology of women and depression. | Ronald C Kessler | J Affect Disord | 2003 | 12646294 | Yes |
3319 | 1022 | 1022.0 | 0.0 | 0.0 | Regional blood flow by fractional distribution of indicators. | L A Sapirstein | Am J Physiol | 1958 | 13521003 | Yes |
3320 | 2044 | 1022.0 | 74.09 | 37.0 | Origins and evolution of antibiotic resistance. | Julian Davies, Dorothy Davies | Microbiol Mol Biol Rev | 2010 | 20805405 | No |
3321 | 1022 | 1022.0 | 37.48 | 37.5 | Electrocatalyst approaches and challenges for automotive fuel cells. | Mark K Debe | Nature | 2012 | 22678278 | Yes |
3322 | 8174 | 1021.8 | 235.42 | 29.4 | A method and server for predicting damaging missense mutations. | Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R Sunyaev | Nat Methods | 2010 | 20354512 | Yes |
3323 | 5106 | 1021.2 | 105.76 | 21.2 | Electrostatics of nanosystems: application to microtubules and the ribosome. | N A Baker, D Sept, S Joseph, M J Holst, J A McCammon | Proc Natl Acad Sci U S A | 2001 | 11517324 | Yes |
3324 | 1021 | 1021.0 | 0.0 | 0.0 | The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle. | M Jouvet | Ergeb Physiol | 1972 | 4403272 | Yes |
3325 | 1021 | 1021.0 | 28.45 | 28.4 | Presynaptic nicotinic ACh receptors. | S Wonnacott | Trends Neurosci | 1997 | 9023878 | No |
3326 | 1021 | 1021.0 | 22.97 | 23.0 | Phenotypic plasticity and the epigenetics of human disease. | Andrew P Feinberg | Nature | 2007 | 17522677 | No |
3327 | 1021 | 1021.0 | 50.95 | 51.0 | Environmentally induced oxidative stress in aquatic animals. | Volodymyr I Lushchak | Aquat Toxicol | 2011 | 21074869 | No |
3328 | 1021 | 1021.0 | 28.93 | 28.9 | Molecular genetics of colorectal cancer. | Eric R Fearon | Annu Rev Pathol | 2011 | 21090969 | No |
3329 | 2041 | 1020.5 | 48.28 | 24.1 | Cellular uptake of the tat protein from human immunodeficiency virus. | A D Frankel, C O Pabo | Cell | 1988 | 2849510 | Yes |
3330 | 2040 | 1020.0 | 78.05 | 39.0 | Visual search and stimulus similarity. | J Duncan, G W Humphreys | Psychol Rev | 1989 | 2756067 | Yes |
3331 | 1020 | 1020.0 | 24.05 | 24.1 | Natural history of chronic hepatitis C. | Leonard B Seeff | Hepatology | 2002 | 12407575 | No |
3332 | 2040 | 1020.0 | 55.45 | 27.7 | Epidemiology of Parkinson's disease. | Lonneke M L de Lau, Monique M B Breteler | Lancet Neurol | 2006 | 16713924 | No |
3333 | 3057 | 1019.0 | 0.0 | 0.0 | Depression: a new animal model sensitive to antidepressant treatments. | R D Porsolt, M Le Pichon, M Jalfre | Nature | 1977 | 559941 | Yes |
3334 | 1019 | 1019.0 | 22.04 | 22.0 | Nucleic acid junctions and lattices. | N C Seeman | J Theor Biol | 1982 | 6188926 | Yes |
3335 | 1019 | 1019.0 | 32.57 | 32.6 | Selective modification of glutathione metabolism. | A Meister | Science | 1983 | 6836290 | Yes |
3336 | 1019 | 1019.0 | 28.41 | 28.4 | Prostaglandin synthase 2. | H R Herschman | Biochim Biophys Acta | 1996 | 8555245 | No |
3337 | 1019 | 1019.0 | 0.0 | 0.0 | Notes on continuous stochastic phenomena. | P A P Moran | Biometrika | 1950 | 15420245 | Yes |
3338 | 1019 | 1019.0 | 21.12 | 21.1 | mTOR and cancer: insights into a complex relationship. | David M Sabatini | Nat Rev Cancer | 2006 | 16915295 | No |
3339 | 2037 | 1018.5 | 46.86 | 23.4 | Obesity and insulin resistance. | B B Kahn, J S Flier | J Clin Invest | 2000 | 10953022 | No |
3340 | 1018 | 1018.0 | 29.26 | 29.3 | Hepatitis B virus. The major etiology of hepatocellular carcinoma. | R P Beasley | Cancer | 1988 | 2834034 | No |
3341 | 2035 | 1017.5 | 40.74 | 20.4 | The druggable genome. | Andrew L Hopkins, Colin R Groom | Nat Rev Drug Discov | 2002 | 12209152 | No |
3342 | 2035 | 1017.5 | 112.74 | 56.4 | Parkinson's disease. | Lorraine V Kalia, Anthony E Lang | Lancet | 2015 | 25904081 | No |
3343 | 1017 | 1017.0 | 52.78 | 52.8 | The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. | J A Koufman | Laryngoscope | 1991 | 1895864 | No |
3344 | 1017 | 1017.0 | 29.83 | 29.8 | Nitric oxide synthase structure and mechanism. | M A Marletta | J Biol Chem | 1993 | 7685338 | No |
3345 | 1017 | 1017.0 | 0.0 | 0.0 | Motivation reconsidered: the concept of competence. | R W White | Psychol Rev | 1959 | 13844397 | Yes |
3346 | 1017 | 1017.0 | 0.0 | 0.0 | Simplified Myeloperoxidase Stain Using Benzidine Dihydrochloride. | L S Kaplow | Blood | 1965 | 14332483 | Yes |
3347 | 1017 | 1017.0 | 22.52 | 22.5 | Up on the tightrope: natural killer cell activation and inhibition. | Lewis L Lanier | Nat Immunol | 2008 | 18425106 | No |
3348 | 4066 | 1016.5 | 136.72 | 34.2 | Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. | W Vale, J Spiess, C Rivier, J Rivier | Science | 1981 | 6267699 | Yes |
3349 | 2033 | 1016.5 | 54.59 | 27.3 | Humans integrate visual and haptic information in a statistically optimal fashion. | Marc O Ernst, Martin S Banks | Nature | 2002 | 11807554 | Yes |
3350 | 2033 | 1016.5 | 65.36 | 32.7 | Health effects of fine particulate air pollution: lines that connect. | C Arden Pope, Douglas W Dockery | J Air Waste Manag Assoc | 2006 | 16805397 | No |
3351 | 1016 | 1016.0 | 33.99 | 34.0 | Agents that increase the permeability of the outer membrane. | M Vaara | Microbiol Rev | 1992 | 1406489 | No |
3352 | 1016 | 1016.0 | 35.17 | 35.2 | Lipid peroxidation and antioxidants as biomarkers of tissue damage. | J M Gutteridge | Clin Chem | 1995 | 7497639 | No |
3353 | 1016 | 1016.0 | 25.06 | 25.1 | Anatomy and regulation of the central melanocortin system. | Roger D Cone | Nat Neurosci | 2005 | 15856065 | No |
3354 | 1016 | 1016.0 | 40.28 | 40.3 | Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. | Rui Wang | Physiol Rev | 2012 | 22535897 | No |
3355 | 8126 | 1015.8 | 323.67 | 40.5 | Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. | R C Kessler, K A McGonagle, S Zhao, C B Nelson, M Hughes, S Eshleman, H U Wittchen, K S Kendler | Arch Gen Psychiatry | 1994 | 8279933 | Yes |
3356 | 1015 | 1015.0 | 23.97 | 24.0 | Hypoxia, HIF1 and glucose metabolism in the solid tumour. | Nicholas C Denko | Nat Rev Cancer | 2008 | 19143055 | No |
3357 | 4059 | 1014.8 | 106.58 | 26.6 | A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. | I Vermes, C Haanen, H Steffens-Nakken, C Reutelingsperger | J Immunol Methods | 1995 | 7622868 | Yes |
3358 | 1014 | 1014.0 | 49.22 | 49.2 | Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder. | M Rutter | Br J Psychiatry | 1985 | 3830321 | Yes |
3359 | 1014 | 1014.0 | 21.14 | 21.1 | Resolution of phase ambiguity in macromolecular crystallography. | B C Wang | Methods Enzymol | 1985 | 4079800 | Yes |
3360 | 1014 | 1014.0 | 0.0 | 0.0 | Fluorescent antibody methods. | A H Coons | Gen Cytochem Methods | 1958 | 13574437 | Yes |
3361 | 3041 | 1013.7 | 84.52 | 28.2 | A nonparametric method for automatic correction of intensity nonuniformity in MRI data. | J G Sled, A P Zijdenbos, A C Evans | IEEE Trans Med Imaging | 1998 | 9617910 | Yes |
3362 | 2027 | 1013.5 | 85.12 | 42.6 | Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. | L A Clark, D Watson | J Abnorm Psychol | 1991 | 1918611 | No |
3363 | 2027 | 1013.5 | 92.01 | 46.0 | Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. | J B Mulliken, J Glowacki | Plast Reconstr Surg | 1982 | 7063565 | Yes |
3364 | 2027 | 1013.5 | 71.56 | 35.8 | Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. | Christine Vogel, Edward M Marcotte | Nat Rev Genet | 2012 | 22411467 | No |
3365 | 1013 | 1013.0 | 22.17 | 22.2 | Potential metal-binding domains in nucleic acid binding proteins. | J M Berg | Science | 1986 | 2421409 | Yes |
3366 | 1013 | 1013.0 | 31.73 | 31.7 | Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion. | E Falk | Circulation | 1985 | 3971539 | Yes |
3367 | 1013 | 1013.0 | 23.51 | 23.5 | Measuring information transfer | Schreiber | Phys Rev Lett | 2000 | 10991308 | Yes |
3368 | 1013 | 1013.0 | 21.87 | 21.9 | Fibrotic disease and the T(H)1/T(H)2 paradigm. | Thomas A Wynn | Nat Rev Immunol | 2004 | 15286725 | No |
3369 | 3038 | 1012.7 | 61.46 | 20.5 | Genetic instabilities in human cancers. | C Lengauer, K W Kinzler, B Vogelstein | Nature | 1998 | 9872311 | No |
3370 | 2025 | 1012.5 | 76.85 | 38.4 | The Modified Mini-Mental State (3MS) examination. | E L Teng, H C Chui | J Clin Psychiatry | 1987 | 3611032 | Yes |
3371 | 2025 | 1012.5 | 48.88 | 24.4 | Regulation of wound healing by growth factors and cytokines. | Sabine Werner, Richard Grose | Physiol Rev | 2003 | 12843410 | No |
3372 | 2025 | 1012.5 | 51.06 | 25.5 | ZINC--a free database of commercially available compounds for virtual screening. | John J Irwin, Brian K Shoichet | J Chem Inf Model | 2005 | 15667143 | Yes |
3373 | 1012 | 1012.0 | 0.0 | 0.0 | Presidental address. Neuropathological aspects of brain edema. | I Klatzo | J Neuropathol Exp Neurol | 1967 | 5336776 | No |
3374 | 1012 | 1012.0 | 0.0 | 0.0 | The interaction of a naphthalene dye with apomyoglobin and apohemoglobin. A fluorescent probe of non-polar binding sites. | L Stryer | J Mol Biol | 1965 | 5867031 | Yes |
3375 | 1012 | 1012.0 | 26.91 | 26.9 | The potential environmental impact of engineered nanomaterials. | Vicki L Colvin | Nat Biotechnol | 2003 | 14520401 | Yes |
3376 | 1012 | 1012.0 | 22.85 | 22.9 | Membrane recognition by phospholipid-binding domains. | Mark A Lemmon | Nat Rev Mol Cell Biol | 2008 | 18216767 | No |
3377 | 1012 | 1012.0 | 20.97 | 21.0 | ChIP-seq: advantages and challenges of a maturing technology. | Peter J Park | Nat Rev Genet | 2009 | 19736561 | No |
3378 | 2022 | 1011.0 | 0.0 | 0.0 | Role of cell shape in growth control. | J Folkman, A Moscona | Nature | 1978 | 661946 | Yes |
3379 | 1011 | 1011.0 | 29.07 | 29.1 | Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease. | W J Welch | Physiol Rev | 1992 | 1438579 | No |
3380 | 1011 | 1011.0 | 34.69 | 34.7 | Why we need observational studies to evaluate the effectiveness of health care. | N Black | BMJ | 1996 | 8634569 | Yes |
3381 | 1011 | 1011.0 | 21.94 | 21.9 | Oxidant signals and oxidative stress. | Toren Finkel | Curr Opin Cell Biol | 2003 | 12648682 | No |
3382 | 2021 | 1010.5 | 0.0 | 0.0 | Analysis of probability as an aid in the clinical diagnosis of coronary-artery disease. | G A Diamond, J S Forrester | N Engl J Med | 1979 | 440357 | Yes |
3383 | 2021 | 1010.5 | 54.64 | 27.3 | Compilation and analysis of Escherichia coli promoter DNA sequences. | D K Hawley, W R McClure | Nucleic Acids Res | 1983 | 6344016 | No |
3384 | 1010 | 1010.0 | 17.55 | 17.6 | Functional inactivation of genes by dominant negative mutations. | I Herskowitz | Nature | 1987 | 2442619 | No |
3385 | 1010 | 1010.0 | 0.0 | 0.0 | Isolation of an organ specific protein antigen from cell-surface membrane of rat liver. | D M Neville | Biochim Biophys Acta | 1968 | 4967807 | Yes |
3386 | 1010 | 1010.0 | 53.82 | 53.8 | Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem. | P D Henry | Am J Cardiol | 1980 | 6255787 | No |
3387 | 1010 | 1010.0 | 36.77 | 36.8 | Methods for dealing with reaction time outliers. | R Ratcliff | Psychol Bull | 1993 | 8272468 | Yes |
3388 | 3030 | 1010.0 | 65.28 | 21.8 | TGF-beta signalling from cell membrane to nucleus through SMAD proteins. | C H Heldin, K Miyazono, P ten Dijke | Nature | 1997 | 9393997 | No |
3389 | 1010 | 1010.0 | 25.3 | 25.3 | Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures. | Frank Würthner | Chem Commun (Camb) | 2004 | 15263926 | Yes |
3390 | 3028 | 1009.3 | 62.65 | 20.9 | The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. | W H Landschulz, P F Johnson, S L McKnight | Science | 1988 | 3289117 | Yes |
3391 | 1009 | 1009.0 | 35.52 | 35.5 | Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance. | M D Majewska | Prog Neurobiol | 1992 | 1349441 | No |
3392 | 1009 | 1009.0 | 38.7 | 38.7 | The ovariectomized rat model of postmenopausal bone loss. | D N Kalu | Bone Miner | 1991 | 1773131 | No |
3393 | 1009 | 1009.0 | 48.98 | 49.0 | Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. | Konrad M Andrassy | Kidney Int | 2013 | 23989362 | Yes |
3394 | 3025 | 1008.3 | 0.0 | 0.0 | Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose. | P L Ey, S J Prowse, C R Jenkin | Immunochemistry | 1978 | 30693 | Yes |
3395 | 1008 | 1008.0 | 49.73 | 49.7 | Self-discrepancy: a theory relating self and affect. | E T Higgins | Psychol Rev | 1987 | 3615707 | Yes |
3396 | 1008 | 1008.0 | 24.32 | 24.3 | Personal genomes: The case of the missing heritability. | Brendan Maher | Nature | 2008 | 18987709 | No |
3397 | 2016 | 1008.0 | 71.38 | 35.7 | LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. | Roman A Laskowski, Mark B Swindells | J Chem Inf Model | 2011 | 21919503 | Yes |
3398 | 2016 | 1008.0 | 112.0 | 56.0 | Making sense of Cronbach's alpha. | Mohsen Tavakol, Reg Dennick | Int J Med Educ | 2011 | 28029643 | No |
3399 | 6045 | 1007.5 | 192.11 | 32.0 | Prevalence of overweight and obesity in the United States, 1999-2004. | Cynthia L Ogden, Margaret D Carroll, Lester R Curtin, Margaret A McDowell, Carolyn J Tabak, Katherine M Flegal | JAMA | 2006 | 16595758 | Yes |
3400 | 1007 | 1007.0 | 0.0 | 0.0 | Avidin. | N M Green | Adv Protein Chem | 1975 | 237414 | Yes |
3401 | 1007 | 1007.0 | 0.0 | 0.0 | Vagal sensory receptors and their reflex effects. | A S Paintal | Physiol Rev | 1973 | 4568412 | No |
3402 | 1007 | 1007.0 | 28.26 | 28.3 | The role of protein phosphorylation in neural and hormonal control of cellular activity. | P Cohen | Nature | 1982 | 6280056 | No |
3403 | 1007 | 1007.0 | 31.04 | 31.0 | Spatially heterogeneous dynamics in supercooled liquids. | M D Ediger | Annu Rev Phys Chem | 2000 | 11031277 | Yes |
3404 | 1007 | 1007.0 | 19.56 | 19.6 | DNA methylation in cancer: too much, but also too little. | Melanie Ehrlich | Oncogene | 2002 | 12154403 | No |
3405 | 1007 | 1007.0 | 0.0 | 0.0 | Histological and histochemical uses of periodic acid. | J F A McMANUS | Stain Technol | 1948 | 18867618 | Yes |
3406 | 1006 | 1006.0 | 29.9 | 29.9 | Cytochrome oxidase: an endogenous metabolic marker for neuronal activity. | M T Wong-Riley | Trends Neurosci | 1989 | 2469224 | No |
3407 | 2012 | 1006.0 | 79.73 | 39.9 | Cronbach's alpha. | J M Bland, D G Altman | BMJ | 1997 | 9055718 | Yes |
3408 | 1006 | 1006.0 | 29.14 | 29.1 | Riddle of biofilm resistance. | K Lewis | Antimicrob Agents Chemother | 2001 | 11257008 | No |
3409 | 1006 | 1006.0 | 24.07 | 24.1 | The prefrontal cortex--an update: time is of the essence. | J M Fuster | Neuron | 2001 | 11394996 | No |
3410 | 2012 | 1006.0 | 46.31 | 23.2 | Regeneration beyond the glial scar. | Jerry Silver, Jared H Miller | Nat Rev Neurosci | 2004 | 14735117 | No |
3411 | 1006 | 1006.0 | 31.25 | 31.2 | Regulation of glutathione synthesis. | Shelly C Lu | Mol Aspects Med | 2009 | 18601945 | No |
3412 | 1006 | 1006.0 | 25.71 | 25.7 | Solid-state nanopores. | Cees Dekker | Nat Nanotechnol | 2007 | 18654264 | No |
3413 | 2012 | 1006.0 | 106.67 | 53.3 | The Emerging Hallmarks of Cancer Metabolism. | Natalya N Pavlova, Craig B Thompson | Cell Metab | 2016 | 26771115 | No |
3414 | 4023 | 1005.8 | 104.03 | 26.0 | Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. | Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod Menon | Proc Natl Acad Sci U S A | 2003 | 12506194 | Yes |
3415 | 1005 | 1005.0 | 25.9 | 25.9 | Molten globule and protein folding. | O B Ptitsyn | Adv Protein Chem | 1995 | 8561052 | No |
3416 | 2009 | 1004.5 | 76.66 | 38.3 | Understanding face recognition. | V Bruce, A Young | Br J Psychol | 1986 | 3756376 | Yes |
3417 | 2009 | 1004.5 | 52.85 | 26.4 | Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. | M Tsujii, R N DuBois | Cell | 1995 | 8521479 | Yes |
3418 | 2008 | 1004.0 | 41.51 | 20.8 | Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. | P E Wright, H J Dyson | J Mol Biol | 1999 | 10550212 | No |
3419 | 4015 | 1003.8 | 0.0 | 0.0 | Coated charcoal immunoassay of insulin. | V Herbert, K S Lau, C W Gottlieb, S J Bleicher | J Clin Endocrinol Metab | 1965 | 5320561 | Yes |
3420 | 3010 | 1003.3 | 100.25 | 33.4 | SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building. | Manolo Gouy, Stéphane Guindon, Olivier Gascuel | Mol Biol Evol | 2010 | 19854763 | Yes |
3421 | 2006 | 1003.0 | 0.0 | 0.0 | Fine structural localization of a blood-brain barrier to exogenous peroxidase. | T S Reese, M J Karnovsky | J Cell Biol | 1967 | 6033532 | Yes |
3422 | 1003 | 1003.0 | 34.08 | 34.1 | A practical computer-based approach to the analysis of radioligand binding experiments. | G A McPherson | Comput Programs Biomed | 1983 | 6319079 | Yes |
3423 | 3009 | 1003.0 | 87.14 | 29.0 | Spirometric reference values from a sample of the general U.S. population. | J L Hankinson, J R Odencrantz, K B Fedan | Am J Respir Crit Care Med | 1999 | 9872837 | Yes |
3424 | 1003 | 1003.0 | 24.96 | 25.0 | Nitric oxide, oxidants, and protein tyrosine nitration. | Rafael Radi | Proc Natl Acad Sci U S A | 2004 | 15020765 | Yes |
3425 | 3008 | 1002.7 | 74.13 | 24.7 | Nitric oxide and macrophage function. | J MacMicking, Q W Xie, C Nathan | Annu Rev Immunol | 1997 | 9143691 | No |
3426 | 1002 | 1002.0 | 0.0 | 0.0 | Serine proteases: structure and mechanism of catalysis. | J Kraut | Annu Rev Biochem | 1977 | 332063 | No |
3427 | 2004 | 1002.0 | 59.99 | 30.0 | Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. | C N Hales, D J Barker | Diabetologia | 1992 | 1644236 | No |
3428 | 3006 | 1002.0 | 878.08 | 292.7 | An interactive web-based dashboard to track COVID-19 in real time. | Ensheng Dong, Hongru Du, Lauren Gardner | Lancet Infect Dis | 2020 | 32087114 | Yes |
3429 | 1001 | 1001.0 | 37.99 | 38.0 | Spin trapping: ESR parameters of spin adducts. | G R Buettner | Free Radic Biol Med | 1987 | 2826304 | No |
3430 | 1001 | 1001.0 | 28.53 | 28.5 | Intermediate filaments: a chemically heterogeneous, developmentally regulated class of proteins. | E Lazarides | Annu Rev Biochem | 1982 | 6180679 | No |
3431 | 2002 | 1001.0 | 40.34 | 20.2 | Cellular functions regulated by Src family kinases. | S M Thomas, J S Brugge | Annu Rev Cell Dev Biol | 1997 | 9442882 | No |
3432 | 2002 | 1001.0 | 58.98 | 29.5 | A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions. | Yan Zhao, Donald G Truhlar | J Chem Phys | 2006 | 17129083 | Yes |
3433 | 2002 | 1001.0 | 89.18 | 44.6 | Methods for the thematic synthesis of qualitative research in systematic reviews. | James Thomas, Angela Harden | BMC Med Res Methodol | 2008 | 18616818 | Yes |
3434 | 2001 | 1000.5 | 0.0 | 0.0 | A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. | G C Liggins, R N Howie | Pediatrics | 1972 | 4561295 | Yes |
3435 | 6001 | 1000.2 | 159.01 | 26.5 | Ghrelin is a growth-hormone-releasing acylated peptide from stomach. | M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K Kangawa | Nature | 1999 | 10604470 | Yes |
3436 | 1000 | 1000.0 | 29.68 | 29.7 | Classes of calcium channels in vertebrate cells. | B P Bean | Annu Rev Physiol | 1989 | 2540697 | No |
3437 | 1000 | 1000.0 | 41.07 | 41.1 | Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. | R J Cousins | Physiol Rev | 1985 | 3885271 | No |
3438 | 2000 | 1000.0 | 62.62 | 31.3 | Multiple significance tests: the Bonferroni method. | J M Bland, D G Altman | BMJ | 1995 | 7833759 | Yes |
3439 | 1000 | 1000.0 | 29.69 | 29.7 | The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. | S Nolen-Hoeksema | J Abnorm Psychol | 2000 | 11016119 | Yes |
3440 | 1000 | 1000.0 | 27.96 | 28.0 | Akaike's information criterion in generalized estimating equations. | W Pan | Biometrics | 2001 | 11252586 | Yes |
3441 | 1000 | 1000.0 | 33.29 | 33.3 | Predictors of postpartum depression: an update. | C T Beck | Nurs Res | 2001 | 11570712 | Yes |
3442 | 1000 | 1000.0 | 24.93 | 24.9 | Differential projections of the infralimbic and prelimbic cortex in the rat. | Robert P Vertes | Synapse | 2004 | 14579424 | Yes |
3443 | 1000 | 1000.0 | 0.0 | 0.0 | The Stability of Broken Ends of Chromosomes in Zea Mays. | B McClintock | Genetics | 1941 | 17247004 | Yes |
3444 | 1000 | 1000.0 | 51.53 | 51.5 | Mechanisms linking social ties and support to physical and mental health. | Peggy A Thoits | J Health Soc Behav | 2011 | 21673143 | No |
3445 | 1999 | 999.5 | 41.69 | 20.8 | In search of the 'missing self': MHC molecules and NK cell recognition. | H G Ljunggren, K Kärre | Immunol Today | 1990 | 2201309 | No |
3446 | 2998 | 999.3 | 79.82 | 26.6 | Use and abuse of HOMA modeling. | Tara M Wallace, Jonathan C Levy, David R Matthews | Diabetes Care | 2004 | 15161807 | No |
3447 | 999 | 999.0 | 31.51 | 31.5 | Topography of cognition: parallel distributed networks in primate association cortex. | P S Goldman-Rakic | Annu Rev Neurosci | 1988 | 3284439 | No |
3448 | 1998 | 999.0 | 59.53 | 29.8 | Glycoprotein hormones: structure and function. | J G Pierce, T F Parsons | Annu Rev Biochem | 1981 | 6267989 | No |
3449 | 998 | 998.0 | 23.13 | 23.1 | Telomere loss: mitotic clock or genetic time bomb? | C B Harley | Mutat Res | 1991 | 1722017 | No |
3450 | 1996 | 998.0 | 0.0 | 0.0 | The period of susceptibility to the physiological effects of unilateral eye closure in kittens. | D H Hubel, T N Wiesel | J Physiol | 1970 | 5498493 | Yes |
3451 | 998 | 998.0 | 32.02 | 32.0 | Food reward: brain substrates of wanting and liking. | K C Berridge | Neurosci Biobehav Rev | 1996 | 8622814 | No |
3452 | 998 | 998.0 | 26.52 | 26.5 | Glutathione and its role in cellular functions. | H Sies | Free Radic Biol Med | 1999 | 10569624 | No |
3453 | 1996 | 998.0 | 36.09 | 18.0 | A synthetic oscillatory network of transcriptional regulators. | M B Elowitz, S Leibler | Nature | 2000 | 10659856 | Yes |
3454 | 3992 | 998.0 | 110.87 | 27.7 | Universal sample preparation method for proteome analysis. | Jacek R Wiśniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias Mann | Nat Methods | 2009 | 19377485 | Yes |
3455 | 1995 | 997.5 | 44.93 | 22.5 | Roles of CHOP/GADD153 in endoplasmic reticulum stress. | S Oyadomari, M Mori | Cell Death Differ | 2004 | 14685163 | No |
3456 | 1994 | 997.0 | 0.0 | 0.0 | Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. | S Ohkuma, B Poole | Proc Natl Acad Sci U S A | 1978 | 28524 | Yes |
3457 | 1994 | 997.0 | 79.25 | 39.6 | Glutathione reductase. | I Carlberg, B Mannervik | Methods Enzymol | 1985 | 3003504 | Yes |
3458 | 997 | 997.0 | 28.91 | 28.9 | Advanced protein glycosylation in diabetes and aging. | M Brownlee | Annu Rev Med | 1995 | 7598459 | No |
3459 | 997 | 997.0 | 37.89 | 37.9 | Cellular mechanisms of muscle fatigue. | R H Fitts | Physiol Rev | 1994 | 8295935 | No |
3460 | 997 | 997.0 | 25.23 | 25.2 | The leptin receptor. | L A Tartaglia | J Biol Chem | 1997 | 9102398 | No |
3461 | 997 | 997.0 | 25.52 | 25.5 | Anti-inflammatory actions of glucocorticoids: molecular mechanisms. | P J Barnes | Clin Sci (Lond) | 1998 | 9854452 | No |
3462 | 997 | 997.0 | 19.7 | 19.7 | Initiation of translation in prokaryotes and eukaryotes. | M Kozak | Gene | 1999 | 10395892 | No |
3463 | 3985 | 996.2 | 120.83 | 30.2 | Measurement of the elastic properties and intrinsic strength of monolayer graphene. | Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James Hone | Science | 2008 | 18635798 | Yes |
3464 | 996 | 996.0 | 0.0 | 0.0 | Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address. | E C Miller | Cancer Res | 1978 | 348302 | No |
3465 | 1992 | 996.0 | 81.4 | 40.7 | A simple method to assess exercise behavior in the community. | G Godin, R J Shephard | Can J Appl Sport Sci | 1985 | 4053261 | Yes |
3466 | 996 | 996.0 | 30.19 | 30.2 | Viability thresholds and the penumbra of focal ischemia. | K A Hossmann | Ann Neurol | 1994 | 7944288 | No |
3467 | 996 | 996.0 | 19.42 | 19.4 | Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins. | M D Resh | Biochim Biophys Acta | 1999 | 10446384 | No |
3468 | 996 | 996.0 | 24.01 | 24.0 | Atherosclerosis is an inflammatory disease. | R Ross | Am Heart J | 1999 | 10539839 | No |
3469 | 1992 | 996.0 | 44.01 | 22.0 | Protein aggregation and neurodegenerative disease. | Christopher A Ross, Michelle A Poirier | Nat Med | 2004 | 15272267 | No |
3470 | 2987 | 995.7 | 86.93 | 29.0 | Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. | Robert G Hart, Lesly A Pearce, Maria I Aguilar | Ann Intern Med | 2007 | 17577005 | Yes |
3471 | 1991 | 995.5 | 0.0 | 0.0 | Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. | M J Mulvany, W Halpern | Circ Res | 1977 | 862138 | Yes |
3472 | 3982 | 995.5 | 100.01 | 25.0 | The epidemiology of sepsis in the United States from 1979 through 2000. | Greg S Martin, David M Mannino, Stephanie Eaton, Marc Moss | N Engl J Med | 2003 | 12700374 | Yes |
Download as CSV