Unicorn Papers

Top ‱ cited papers from PUBMED

Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authors
Currently, the list contains 3433 papers with ECcit ≥ 989.0
‱ - permyriad, , literally meaning "for (every) myriad (ten thousand)"

Volume 12, August 2021

No. Citations ECcit RCR ECRCR Title Authors Journal Year PMID Article(?)
1221093221093.00.00.0Cleavage of structural proteins during the assembly of the head of bacteriophage T4. U K LaemmliNature19705432063Yes
2167829167829.00.00.0A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. M M BradfordAnal Biochem1976942051Yes
328778571946.20.00.0Protein measurement with the Folin phenol reagent. O H Lowry, N J Rosebrough, A L Farr, R J RandallJ Biol Chem195114907713Yes
49327146635.52411.621205.8Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. K J Livak, T D SchmittgenMethods200111846609Yes
54274642746.01460.761460.8A short history of SHELX. George M SheldrickActa Crystallogr A200818156677Yes
63323533235.01076.481076.5Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. T MosmannJ Immunol Methods19836606682Yes
76521632608.01977.38988.7Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. P Chomczynski, N SacchiAnal Biochem19872440339Yes
83015730157.00.00.0Detection of specific sequences among DNA fragments separated by gel electrophoresis. E M SouthernJ Mol Biol19751195397Yes
92501725017.00.00.0The assessment and analysis of handedness: the Edinburgh inventory. R C OldfieldNeuropsychologia19715146491Yes
102445524455.0570.03570.0MicroRNAs: genomics, biogenesis, mechanism, and function. David P BartelCell200414744438No
112332223322.00.00.0A rating scale for depression. M HamiltonJ Neurol Neurosurg Psychiatry196014399272Yes
122203022030.0691.46691.5Confidence Limits On Phylogenies: An Approach Using The Bootstrap. Joseph FelsensteinEvolution198528561359Yes
136525121750.30.00.0DNA sequencing with chain-terminating inhibitors. F Sanger, S Nicklen, A R CoulsonProc Natl Acad Sci U S A1977271968Yes
142105821058.0503.7503.7A new mathematical model for relative quantification in real-time RT-PCR. M W PfafflNucleic Acids Res200111328886Yes
152100521005.0526.87526.9MUSCLE: multiple sequence alignment with high accuracy and high throughput. Robert C EdgarNucleic Acids Res200415034147Yes
161989819898.00.00.0The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. E S ReynoldsJ Cell Biol196313986422Yes
175937919793.00.00.0"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. M F Folstein, S E Folstein, P R McHughJ Psychiatr Res19751202204Yes
183634918174.51126.75563.4The neighbor-joining method: a new method for reconstructing phylogenetic trees. N Saitou, M NeiMol Biol Evol19873447015Yes
191791117911.00.00.0Tissue sulfhydryl groups. G L EllmanArch Biochem Biophys195913650640Yes
205309317697.70.00.0Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. H Towbin, T Staehelin, J GordonProc Natl Acad Sci U S A1979388439Yes
211682616826.00.00.0Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. B J DavisAnn N Y Acad Sci196414240539Yes
221666516665.00.00.0High resolution two-dimensional electrophoresis of proteins. P H O'FarrellJ Biol Chem1975236308Yes
233319816599.01612.33806.2Statistical methods for assessing agreement between two methods of clinical measurement. J M Bland, D G AltmanLancet19862868172Yes
241623016230.0577.95578.0Density-functional exchange-energy approximation with correct asymptotic behavior. BeckePhys Rev A Gen Phys19889900728Yes
251598615986.0419.26419.3Atherosclerosis--an inflammatory disease. R RossN Engl J Med19999887164No
261590115901.00.00.0A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. K BurtonBiochem J195613293190Yes
273121315606.51133.12566.6Hallmarks of cancer: the next generation. Douglas Hanahan, Robert A WeinbergCell201121376230No
283036915184.50.00.0A rapid method of total lipid extraction and purification. E G Bligh, W J DyerCan J Biochem Physiol195913671378Yes
291511315113.0563.15563.1A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. M KimuraJ Mol Evol19807463489Yes
302889414447.00.00.0The measurement of observer agreement for categorical data. J R Landis, G G KochBiometrics1977843571Yes
314308814362.71245.49415.2CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. J D Thompson, D G Higgins, T J GibsonNucleic Acids Res19947984417Yes
324153713845.70.00.0A simple method for the isolation and purification of total lipides from animal tissues. J Folch, M Lees, G H Sloane StanleyJ Biol Chem195713428781Yes
331319113191.0368.42368.4MicroRNAs: target recognition and regulatory functions. David P BartelCell200919167326No
341280112801.00.00.0Phosphorus assay in column chromatography. G R BartlettJ Biol Chem195913641241Yes
351271412714.0540.99541.0A power primer. J CohenPsychol Bull199219565683Yes
362512212561.0972.17486.1Meta-analysis in clinical trials. R DerSimonian, N LairdControl Clin Trials19863802833Yes
371232412324.0368.79368.8Projector augmented-wave method. BlöchlPhys Rev B Condens Matter19949976227Yes
382447812239.01023.88511.9The hospital anxiety and depression scale. A S Zigmond, R P SnaithActa Psychiatr Scand19836880820Yes
391179011790.0469.12469.1Catalase in vitro. H AebiMethods Enzymol19846727660Yes
401100011000.0596.52596.5RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Alexandros StamatakisBioinformatics201424451623Yes
412190410952.0933.99467.0The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. J E Ware, C D SherbourneMed Care19921593914Yes
425462610925.21581.11316.2Basic local alignment search tool. S F Altschul, W Gish, W Miller, E W Myers, D J LipmanJ Mol Biol19902231712Yes
432155810779.0559.74279.9A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. A P Feinberg, B VogelsteinAnal Biochem19836312838Yes
442119610598.0472.67236.3Coot: model-building tools for molecular graphics. Paul Emsley, Kevin CowtanActa Crystallogr D Biol Crystallogr200415572765Yes
453177510591.7995.26331.8Generalized Gradient Approximation Made Simple. Perdew, Burke, ErnzerhofPhys Rev Lett199610062328Yes
461030610306.00.00.0Improvements in epoxy resin embedding methods. J H LuftJ Biophys Biochem Cytol196113764136Yes
471022710227.0346.38346.4Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). J F KurtzkeNeurology19836685237Yes
482010110050.50.00.0The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. K Weber, M OsbornJ Biol Chem19695806584Yes
491001210012.0398.75398.8Structure validation in chemical crystallography. Anthony L SpekActa Crystallogr D Biol Crystallogr200919171970Yes
50198859942.5561.73280.9Fast and accurate short read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics200919451168Yes
5198929892.00.00.0The genetics of Caenorhabditis elegans. S BrennerGenetics19744366476Yes
52294739824.31081.0360.3Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. Lee, Yang, ParrPhys Rev B Condens Matter19889944570Yes
5397919791.0304.68304.7The Psychophysics Toolbox. D H BrainardSpat Vis19979176952Yes
54195109755.0441.79220.9[20] Processing of X-ray diffraction data collected in oscillation mode. Zbyszek Otwinowski, Wladek MinorMethods Enzymol199727799103Yes
5595819581.0358.37358.4Search and clustering orders of magnitude faster than BLAST. Robert C EdgarBioinformatics201020709691Yes
5694649464.00.00.0Self-efficacy: toward a unifying theory of behavioral change. A BanduraPsychol Rev1977847061Yes
5794259425.0324.73324.7Banting lecture 1988. Role of insulin resistance in human disease. G M ReavenDiabetes19883056758No
5894189418.0277.15277.1Xds. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124692Yes
5992489248.0268.88268.9Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. P S ThomasProc Natl Acad Sci U S A19806159641Yes
60181139056.5680.84340.4Fast gapped-read alignment with Bowtie 2. Ben Langmead, Steven L SalzbergNat Methods201222388286Yes
6190379037.0240.53240.5Studies on transformation of Escherichia coli with plasmids. D HanahanJ Mol Biol19836345791Yes
62180639031.5475.2237.6A simple method for displaying the hydropathic character of a protein. J Kyte, R F DoolittleJ Mol Biol19827108955Yes
6390229022.0260.28260.3The pathogenesis of atherosclerosis: a perspective for the 1990s. R RossNature19938479518No
6489658965.0354.59354.6A new method for measuring daytime sleepiness: the Epworth sleepiness scale. M W JohnsSleep19911798888Yes
6589188918.0235.37235.4Integrins: versatility, modulation, and signaling in cell adhesion. R O HynesCell19921555235No
66178048902.0813.19406.6The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. R M Baron, D A KennyJ Pers Soc Psychol19863806354Yes
6785028502.0600.94600.9Crystal structure refinement with SHELXL. George M SheldrickActa Crystallogr C Struct Chem201525567568Yes
68169918495.5485.69242.8Quantifying heterogeneity in a meta-analysis. Julian P T Higgins, Simon G ThompsonStat Med200212111919Yes
6984448444.0187.07187.1Mfold web server for nucleic acid folding and hybridization prediction. Michael ZukerNucleic Acids Res200312824337Yes
7083278327.0237.96238.0Evolutionary trees from DNA sequences: a maximum likelihood approach. J FelsensteinJ Mol Evol19817288891Yes
7183028302.0231.95231.9RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. Alexandros StamatakisBioinformatics200616928733Yes
7281548154.00.00.0On the origin of cancer cells. O WarburgScience195613298683Yes
7381548154.0259.68259.7Vitamin D deficiency. Michael F HolickN Engl J Med200717634462No
7480468046.0173.86173.9Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Gordon K SmythStat Appl Genet Mol Biol200416646809Yes
75160448022.0353.07176.5The hallmarks of cancer. D Hanahan, R A WeinbergCell200010647931No
7679757975.00.00.0Solvent content of protein crystals. B W MatthewsJ Mol Biol19685700707Yes
77159347967.0468.56234.3Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. Kresse, FurthmüllerPhys Rev B Condens Matter19969984901Yes
7878637863.0355.01355.0Psychophysical bases of perceived exertion. G A BorgMed Sci Sports Exerc19827154893Yes
79233377779.0625.59208.5VMD: visual molecular dynamics. W Humphrey, A Dalke, K SchultenJ Mol Graph19968744570Yes
8077617761.0218.29218.3The role of protein kinase C in cell surface signal transduction and tumour promotion. Y NishizukaNature19846232463No
8177297729.0217.88217.9"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. W N BurnetteAnal Biochem19816266278Yes
8276667666.00.00.0A simplification of the protein assay method of Lowry et al. which is more generally applicable. G L PetersonAnal Biochem1977603028Yes
8376537653.0171.11171.1The functions of animal microRNAs. Victor AmbrosNature200415372042No
84305297632.2931.44232.9Measuring inconsistency in meta-analyses. Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G AltmanBMJ200312958120No
8575667566.00.00.0Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. J R VaneNat New Biol19715284360Yes
8674137413.00.00.0Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. D I ArnonPlant Physiol194916654194Yes
8773407340.0201.0201.0Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. M C HochbergArthritis Rheum19979324032Yes
88145937296.5348.07174.0Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Kazutoshi Takahashi, Shinya YamanakaCell200616904174Yes
8972217221.00.00.0A low-viscosity epoxy resin embedding medium for electron microscopy. A R SpurrJ Ultrastruct Res19694887011Yes
9072097209.0213.6213.6Semiempirical GGA-type density functional constructed with a long-range dispersion correction. Stefan GrimmeJ Comput Chem200616955487Yes
91285127128.01103.18275.8A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. M E Charlson, P Pompei, K L Ales, C R MacKenzieJ Chronic Dis19873558716Yes
92211567052.0606.51202.2Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Da Wei Huang, Brad T Sherman, Richard A LempickiNat Protoc200919131956Yes
9370447044.00.00.0Tumor angiogenesis: therapeutic implications. J FolkmanN Engl J Med19714938153No
9470267026.00.00.0Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. A BöyumScand J Clin Lab Invest Suppl19684179068Yes
9569896989.0194.08194.1TreeView: an application to display phylogenetic trees on personal computers. R D PageComput Appl Biosci19968902363Yes
96139646982.0356.64178.3MrBayes 3: Bayesian phylogenetic inference under mixed models. Fredrik Ronquist, John P HuelsenbeckBioinformatics200312912839Yes
97206156871.70.00.0Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. W T Friedewald, R I Levy, D S FredricksonClin Chem19724337382Yes
98478926841.71271.3181.6Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J LipmanNucleic Acids Res19979254694No
9968416841.00.00.0The thiobarbituric acid assay of sialic acids. L WarrenJ Biol Chem195913672998Yes
100272186804.51194.39298.6Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanPLoS Med200919621072No
10167516751.0206.2206.2AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. R W CoxComput Biomed Res19968812068Yes
10267316731.0183.59183.6The steroid and thyroid hormone receptor superfamily. R M EvansScience19883283939No
103201686722.7576.84192.3A new generation of Ca2+ indicators with greatly improved fluorescence properties. G Grynkiewicz, M Poenie, R Y TsienJ Biol Chem19853838314Yes
104134106705.00.00.0Continuous cultures of fused cells secreting antibody of predefined specificity. G Köhler, C MilsteinNature19751172191Yes
105267296682.2896.38224.1Bias in meta-analysis detected by a simple, graphical test. M Egger, G Davey Smith, M Schneider, C MinderBMJ19979310563Yes
106132526626.0287.44143.7 Processing of X-ray diffraction data collected in oscillation mode. Z Otwinowski, W MinorMethods Enzymol199727754618Yes
107198556618.3793.15264.4NIH Image to ImageJ: 25 years of image analysis. Caroline A Schneider, Wayne S Rasband, Kevin W EliceiriNat Methods201222930834No
10866186618.0154.68154.7Chromatin modifications and their function. Tony KouzaridesCell200717320507No
109132076603.5382.3191.2Analyzing real-time PCR data by the comparative C(T) method. Thomas D Schmittgen, Kenneth J LivakNat Protoc200818546601Yes
11065926592.0230.44230.4The blockade of immune checkpoints in cancer immunotherapy. Drew M PardollNat Rev Cancer201222437870No
11165816581.0177.72177.7Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. F TajimaGenetics19892513255Yes
11265086508.0261.6261.6Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Andreas StangEur J Epidemiol201020652370Yes
11364936493.0170.95170.9PAML 4: phylogenetic analysis by maximum likelihood. Ziheng YangMol Biol Evol200717483113Yes
11464866486.0172.67172.7Adhesion receptors of the immune system. T A SpringerNature19901974032No
11564776477.0311.04311.0Comparative fit indexes in structural models. P M BentlerPsychol Bull19902320703Yes
11664446444.0177.56177.6Canonical dynamics: Equilibrium phase-space distributions. HooverPhys Rev A Gen Phys19859895674Yes
117127726386.0295.98148.0Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. S J Clough, A F BentPlant J199810069079Yes
11863566356.0169.19169.2Angiogenesis in cancer, vascular, rheumatoid and other disease. J FolkmanNat Med19957584949No
11963516351.0129.77129.8Rapid and efficient site-specific mutagenesis without phenotypic selection. T A KunkelProc Natl Acad Sci U S A19853881765Yes
12063316331.00.00.0The assessment of anxiety states by rating. M HamiltonBr J Med Psychol195913638508Yes
121126166308.00.00.0Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Y Cheng, W H PrusoffBiochem Pharmacol19734202581Yes
12262906290.0164.29164.3Fast robust automated brain extraction. Stephen M SmithHum Brain Mapp200212391568No
123188646288.0857.81285.9Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Michael I Love, Wolfgang Huber, Simon AndersGenome Biol201425516281Yes
12462516251.0213.55213.6Density-functional approximation for the correlation energy of the inhomogeneous electron gas. PerdewPhys Rev B Condens Matter19869938299Yes
125124656232.50.00.0Statistical aspects of the analysis of data from retrospective studies of disease. N Mantel, W HaenszelJ Natl Cancer Inst195913655060Yes
12662046204.0193.17193.2The VideoToolbox software for visual psychophysics: transforming numbers into movies. D G PelliSpat Vis19979176953Yes
12761366136.0204.72204.7Ethical guidelines for investigations of experimental pain in conscious animals. Manfred ZimmermannPain19836877845No
12861256125.0135.77135.8p53, the cellular gatekeeper for growth and division. A J LevineCell19979039259No
129121836091.50.00.0A rapid alkaline extraction procedure for screening recombinant plasmid DNA. H C Birnboim, J DolyNucleic Acids Res1979388356Yes
130120316015.5268.48134.2KEGG: kyoto encyclopedia of genes and genomes. M Kanehisa, S GotoNucleic Acids Res200010592173Yes
13160116011.0150.41150.4Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. T A SpringerCell19947507411No
13260056005.0172.6172.6Apoptosis: a review of programmed cell death. Susan ElmoreToxicol Pathol200717562483No
133239765994.00.00.0Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. J M Chirgwin, A E Przybyla, R J MacDonald, W J RutterBiochemistry1979518835Yes
13459305930.0152.28152.3Inositol trisphosphate and calcium signalling. M J BerridgeNature19938381210No
13559085908.0152.23152.2G proteins: transducers of receptor-generated signals. A G GilmanAnnu Rev Biochem19873113327No
136118015900.50.00.0Prediction of creatinine clearance from serum creatinine. D W Cockcroft, M H GaultNephron19761244564Yes
137117655882.5554.81277.4MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Kazutaka Katoh, Daron M StandleyMol Biol Evol201323329690Yes
13858025802.0121.51121.5Integrins: bidirectional, allosteric signaling machines. Richard O HynesCell200212297042No
13957975797.0191.7191.7The Clinical Dementia Rating (CDR): current version and scoring rules. J C MorrisNeurology19938232972Yes
14057675767.0133.35133.3Inflammation in atherosclerosis. Peter LibbyNature200212490960No
141114935746.50.00.0The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. T Omura, R SatoJ Biol Chem196414209971Yes
142114315715.50.00.0Intraclass correlations: uses in assessing rater reliability. P E Shrout, J L FleissPsychol Bull197918839484No
143171115703.7848.07282.7Trimmomatic: a flexible trimmer for Illumina sequence data. Anthony M Bolger, Marc Lohse, Bjoern UsadelBioinformatics201424695404Yes
14456695669.0144.23144.2Inflammation, atherosclerosis, and coronary artery disease. Göran K HanssonN Engl J Med200515843671No
14556345634.0277.88277.9Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Y KandaBone Marrow Transplant201323208313Yes
14656225622.0144.38144.4Apoptosis in the pathogenesis and treatment of disease. C B ThompsonScience19957878464No
147111995599.5400.85200.4The meaning and use of the area under a receiver operating characteristic (ROC) curve. J A Hanley, B J McNeilRadiology19827063747Yes
14855735573.0138.58138.6Biochemistry and molecular cell biology of diabetic complications. M BrownleeNature200111742414Yes
149167025567.31362.36454.1MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Sudhir Kumar, Glen Stecher, Koichiro TamuraMol Biol Evol201627004904Yes
15055105510.00.00.0A Self-Rating Depression Scale. W W ZungArch Gen Psychiatry196514221692Yes
15154705470.0135.17135.2Free radicals in the physiological control of cell function. Wulf DrögePhysiol Rev200211773609No
152108925446.0252.18126.1Dendritic cells and the control of immunity. J Banchereau, R M SteinmanNature19989521319No
153108835441.5293.89146.9Sequencing end-labeled DNA with base-specific chemical cleavages. A M Maxam, W GilbertMethods Enzymol19806246368Yes
154108635431.50.00.0A series of normal stages in the development of the chick embryo. V Hamburger, H L HamiltonJ Morphol195124539719Yes
155108195409.5273.1136.6MRBAYES: Bayesian inference of phylogenetic trees. J P Huelsenbeck, F RonquistBioinformatics200111524383Yes
15654035403.00.00.0Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. F TietzeAnal Biochem19694388022Yes
15753615361.0137.0137.0New M13 vectors for cloning. J MessingMethods Enzymol19836310323Yes
158160635354.30.00.0Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. H Ohkawa, N Ohishi, K YagiAnal Biochem197936810Yes
15952845284.00.00.0Evaluation of survival data and two new rank order statistics arising in its consideration. N MantelCancer Chemother Rep19665910392Yes
16052825282.0104.7104.7BLAT--the BLAST-like alignment tool. W James KentGenome Res200211932250Yes
16152545254.0128.37128.4Antimicrobial peptides of multicellular organisms. Michael ZasloffNature200211807545Yes
16252525252.0152.97153.0Studies and perspectives of protein kinase C. Y NishizukaScience19863014651No
16352475247.00.00.0Modification of seizure activity by electrical stimulation. II. Motor seizure. R J RacineElectroencephalogr Clin Neurophysiol19724110397Yes
16452425242.0118.87118.9The biochemistry of apoptosis. M O HengartnerNature200011048727No
16552335233.0191.04191.0The Strengths and Difficulties Questionnaire: a research note. R GoodmanJ Child Psychol Psychiatry19979255702Yes
16652335233.0142.6142.6The Cambridge Structural Database: a quarter of a million crystal structures and rising. Frank H AllenActa Crystallogr B200212037359Yes
16752215221.00.00.0[A micro-method of immuno-electrophoresis]. J J ScheideggerInt Arch Allergy Appl Immunol195513262900Yes
168104035201.5300.63150.3MODELTEST: testing the model of DNA substitution. D Posada, K A CrandallBioinformatics19989918953Yes
169155815193.7473.41157.8A simple salting out procedure for extracting DNA from human nucleated cells. S A Miller, D D Dykes, H F PoleskyNucleic Acids Res19883344216Yes
17051755175.00.00.0Selective extraction of polyoma DNA from infected mouse cell cultures. B HirtJ Mol Biol19674291934Yes
171103465173.0244.39122.2Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. W Kabsch, C SanderBiopolymers19836667333Yes
172154805160.0508.87169.6Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Daniel Dindo, Nicolas Demartines, Pierre-Alain ClavienAnn Surg200415273542Yes
17351545154.0190.32190.3Oxygen-derived free radicals in postischemic tissue injury. J M McCordN Engl J Med19852981404No
17451095109.00.00.0The Environment And Disease: Association Or Causation? A B HillProc R Soc Med196514283879Yes
175102185109.0250.61125.3A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Stéphane Guindon, Olivier GascuelSyst Biol200314530136Yes
17651015101.0126.23126.2The NF-kappa B and I kappa B proteins: new discoveries and insights. A S BaldwinAnnu Rev Immunol19968717528No
177254225084.4701.32140.3The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G HigginsNucleic Acids Res19979396791Yes
17850835083.00.00.0Mutation and cancer: statistical study of retinoblastoma. A G KnudsonProc Natl Acad Sci U S A19715279523Yes
179100865043.0374.0187.0The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. R F Furchgott, J V ZawadzkiNature19806253831Yes
180100285014.0267.66133.8Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. H Schägger, G von JagowAnal Biochem19872449095Yes
18149974997.00.00.0Aging: a theory based on free radical and radiation chemistry. D HarmanJ Gerontol195613332224Yes
18249974997.0174.8174.8jModelTest: phylogenetic model averaging. David PosadaMol Biol Evol200818397919Yes
18349884988.0130.73130.7Inflammation and metabolic disorders. Gökhan S HotamisligilNature200617167474No
18449804980.00.00.0A protein binding assay for adenosine 3':5'-cyclic monophosphate. A G GilmanProc Natl Acad Sci U S A19704318781Yes
18549764976.0202.45202.4Orienting of attention. M I PosnerQ J Exp Psychol19807367577Yes
18699214960.5228.22114.1One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. K A Datsenko, B L WannerProc Natl Acad Sci U S A200010829079Yes
18749474947.0183.34183.3Analyzing Tables Of Statistical Tests. William R RiceEvolution198928568501Yes
18849464946.00.00.0Development of a rating scale for primary depressive illness. M HamiltonBr J Soc Clin Psychol19676080235Yes
18949434943.0261.45261.4UPARSE: highly accurate OTU sequences from microbial amplicon reads. Robert C EdgarNat Methods201323955772Yes
19049394939.0117.64117.6Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. J CastresanaMol Biol Evol200010742046Yes
19149354935.00.00.0Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. C B LaurellAnal Biochem19665959431Yes
192147934931.0539.79179.9Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. S M Hsu, L Raine, H FangerJ Histochem Cytochem19816166661Yes
19349314931.0102.44102.4Rho GTPases and the actin cytoskeleton. A HallScience19989438836No
19497934896.5356.94178.5Ligand: a versatile computerized approach for characterization of ligand-binding systems. P J Munson, D RodbardAnal Biochem19806254391Yes
19548844884.00.00.0Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. M RodbellJ Biol Chem196414169133Yes
196146124870.7440.05146.7edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Mark D Robinson, Davis J McCarthy, Gordon K SmythBioinformatics201019910308Yes
19797184859.0276.31138.2Neuropathological stageing of Alzheimer-related changes. H Braak, E BraakActa Neuropathol19911759558No
198144914830.3394.77131.6Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. C Yanisch-Perron, J Vieira, J MessingGene19852985470Yes
199144734824.3360.49120.2A comprehensive set of sequence analysis programs for the VAX. J Devereux, P Haeberli, O SmithiesNucleic Acids Res19846546423Yes
20048244824.099.0599.0Epithelial-mesenchymal transitions in tumour progression. Jean Paul ThieryNat Rev Cancer200212189386No
201144244808.00.00.0Determination of serum proteins by means of the biuret reaction. A G Gornall, C J Bardawill, M M DavidJ Biol Chem194918110453Yes
20295554777.50.00.0A quantitative description of membrane current and its application to conduction and excitation in nerve. A L Hodgkin, A F HuxleyJ Physiol195212991237Yes
20347704770.0144.62144.6Developments of a water-maze procedure for studying spatial learning in the rat. R MorrisJ Neurosci Methods19846471907Yes
20447674767.097.2697.3An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. M KozakNucleic Acids Res19873313277No
20547674767.0133.18133.2Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. P MatsudairaJ Biol Chem19873611052Yes
20695244762.0352.0176.0Three approaches to qualitative content analysis. Hsiu-Fang Hsieh, Sarah E ShannonQual Health Res200516204405Yes
207142594753.0445.52148.5The PHQ-9: validity of a brief depression severity measure. K Kroenke, R L Spitzer, J B WilliamsJ Gen Intern Med200111556941Yes
20894434721.50.00.0A new technique for the assay of infectivity of human adenovirus 5 DNA. F L Graham, A J van der EbVirology19734705382Yes
20947004700.0273.76273.8Prokka: rapid prokaryotic genome annotation. Torsten SeemannBioinformatics201424642063Yes
21046704670.00.00.0The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. P LaurenActa Pathol Microbiol Scand196514320675Yes
21193144657.0237.33118.7Improved tools for biological sequence comparison. W R Pearson, D J LipmanProc Natl Acad Sci U S A19883162770Yes
21246534653.0106.77106.8ras oncogenes in human cancer: a review. J L BosCancer Res19892547513No
21346504650.0158.63158.6The pathogenesis of atherosclerosis--an update. R RossN Engl J Med19863511384No
21446484648.0118.49118.5Emotion circuits in the brain. J E LeDouxAnnu Rev Neurosci200010845062No
21546404640.0133.8133.8A modified poisson regression approach to prospective studies with binary data. Guangyong ZouAm J Epidemiol200415033648Yes
216277534625.53485.68580.9Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin JemalCA Cancer J Clin201830207593Yes
21792424621.0228.48114.2A genetic model for colorectal tumorigenesis. E R Fearon, B VogelsteinCell19902188735No
218138534617.7487.27162.4Nitric oxide: physiology, pathophysiology, and pharmacology. S Moncada, R M Palmer, E A HiggsPharmacol Rev19911852778No
21992294614.5225.11112.6Comparative protein modelling by satisfaction of spatial restraints. A Sali, T L BlundellJ Mol Biol19938254673Yes
22046084608.0104.27104.3Cancer cell cycles. C J SherrScience19968939849No
22145854585.00.00.0Aggregation of blood platelets by adenosine diphosphate and its reversal. G V BornNature196213871375Yes
22245794579.00.00.0A rapid banding technique for human chromosomes. M SeabrightLancet19714107917Yes
223182764569.0573.24143.3MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir KumarMol Biol Evol200717488738Yes
22491124556.00.00.0A new depression scale designed to be sensitive to change. S A Montgomery, M AsbergBr J Psychiatry1979444788Yes
22590374518.5203.47101.7Inflammation and cancer. Lisa M Coussens, Zena WerbNature200212490959No
22690304515.00.00.0Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J M McCord, I FridovichJ Biol Chem19695389100Yes
22790234511.5207.71103.9The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. John Hardy, Dennis J SelkoeScience200212130773No
22845094509.0307.34307.3SHELXT - integrated space-group and crystal-structure determination. George M SheldrickActa Crystallogr A Found Adv201525537383Yes
22989914495.5263.83131.9EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Arnaud Delorme, Scott MakeigJ Neurosci Methods200415102499Yes
23044944494.00.00.0The clonal evolution of tumor cell populations. P C NowellScience1976959840Yes
231134814493.7521.65173.9The positive and negative syndrome scale (PANSS) for schizophrenia. S R Kay, A Fiszbein, L A OplerSchizophr Bull19873616518Yes
23244524452.097.7597.8ras genes. M BarbacidAnnu Rev Biochem19873304147No
233133564452.0302.64100.9Refinement of macromolecular structures by the maximum-likelihood method. G N Murshudov, A A Vagin, E J DodsonActa Crystallogr D Biol Crystallogr199715299926Yes
23444464446.0109.09109.1A new method for predicting signal sequence cleavage sites. G von HeijneNucleic Acids Res19863714490Yes
23588894444.50.00.0A simplified method of evaluating dose-effect experiments. J T Litchfield, F WilcoxonJ Pharmacol Exp Ther194918152921Yes
23644294429.095.8195.8Targeting HIF-1 for cancer therapy. Gregg L SemenzaNat Rev Cancer200313130303No
23744144414.0135.0135.0A fast diffeomorphic image registration algorithm. John AshburnerNeuroimage200717761438Yes
23888164408.0311.28155.6AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Oleg Trott, Arthur J OlsonJ Comput Chem201019499576Yes
23944054405.00.00.0The McGill Pain Questionnaire: major properties and scoring methods. Ronald MelzackPain19751235985Yes
24088074403.5236.54118.3BEDTools: a flexible suite of utilities for comparing genomic features. Aaron R Quinlan, Ira M HallBioinformatics201020110278Yes
24187874393.50.00.0A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. W M Bonner, R A LaskeyEur J Biochem19744850204Yes
242219154383.00.00.0An inventory for measuring depression. A T Beck, C H Ward, M Mendelson, J Mock, J ErbaughArch Gen Psychiatry196113688369Yes
24343604360.0101.02101.0Alzheimer's disease: genes, proteins, and therapy. D J SelkoePhysiol Rev200111274343No
244217844356.81162.3232.5MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir KumarMol Biol Evol201324132122Yes
24543524352.089.5989.6Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. M KozakCell19863943125Yes
24643484348.00.00.0Index for rating diagnostic tests. W J YoudenCancer195015405679Yes
24743444344.00.00.0Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. M M MesulamJ Histochem Cytochem197824068Yes
24886804340.0200.14100.1Primer3 on the WWW for general users and for biologist programmers. S Rozen, H SkaletskyMethods Mol Biol200010547847Yes
249130114337.0332.67110.9Inference of population structure using multilocus genotype data. J K Pritchard, M Stephens, P DonnellyGenetics200010835412Yes
25043364336.085.6785.7DNA methylation patterns and epigenetic memory. Adrian BirdGenes Dev200211782440No
25143304330.0102.25102.2MUSCLE: a multiple sequence alignment method with reduced time and space complexity. Robert C EdgarBMC Bioinformatics200415318951Yes
252173064326.5615.59153.9G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel BuchnerBehav Res Methods200717695343Yes
25343104310.00.00.0Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. W H HarrisJ Bone Joint Surg Am19695783851Yes
25443024302.099.99100.0Prions. S B PrusinerProc Natl Acad Sci U S A19989811807No
25542974297.0112.7112.7Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Y NishizukaScience19921411571No
25685934296.50.00.0Preparation of iodine-131 labelled human growth hormone of high specific activity. W M Hunter, F C GreenwoodNature196214450081Yes
25742794279.00.00.0The Limited In Vitro Lifetime Of Human Diploid Cell Strains. L HayflickExp Cell Res196514315085Yes
25885504275.0290.74145.4Operating characteristics of a rank correlation test for publication bias. C B Begg, M MazumdarBiometrics19947786990Yes
25942534253.0113.48113.5The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Y NishizukaNature19883045562No
26084654232.50.00.0Parkinsonism: onset, progression and mortality. M M Hoehn, M D YahrNeurology19676067254Yes
26142324232.0120.38120.4Mild cognitive impairment as a diagnostic entity. R C PetersenJ Intern Med200415324362No
26242164216.0112.75112.8Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. A H WyllieNature19806245367Yes
26342144214.0168.79168.8Revisiting the behavioral model and access to medical care: does it matter? R M AndersenJ Health Soc Behav19957738325Yes
26442134213.094.5294.5Apoptosis by death factor. S NagataCell19979039262No
26542124212.0100.42100.4Cancer. p53, guardian of the genome. D P LaneNature19921614522No
26642084208.094.4594.5Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. S HenikoffGene19846235151Yes
267252474207.81023.78170.6Global cancer statistics. Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David FormanCA Cancer J Clin201121296855Yes
26842014201.00.00.0Amino acid metabolism in mammalian cell cultures. H EagleScience195913675766Yes
26983874193.5229.59114.8A synaptic model of memory: long-term potentiation in the hippocampus. T V Bliss, G L CollingridgeNature19938421494No
27041914191.00.00.0A relation between non-esterified fatty acids in plasma and the metabolism of glucose. V P DoleJ Clin Invest195613286333Yes
27141794179.00.00.0The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. T NashBiochem J195313105648Yes
27241734173.00.00.0Estimation of nuclear population from microtome sections. M AbercrombieAnat Rec194621015608Yes
27383174158.5241.14120.6Differential expression analysis for sequence count data. Simon Anders, Wolfgang HuberGenome Biol201020979621Yes
27482724136.0247.71123.9The rise of graphene. A K Geim, K S NovoselovNat Mater200717330084Yes
27541324132.00.00.0The genetical evolution of social behaviour. I. W D HamiltonJ Theor Biol19645875341Yes
27641244124.00.00.0The need for a new medical model: a challenge for biomedicine. G L EngelScience1977847460Yes
27782394119.5178.7289.4Genomic sequencing. G M Church, W GilbertProc Natl Acad Sci U S A19846326095Yes
27882374118.50.00.0Assessment of coma and impaired consciousness. A practical scale. G Teasdale, B JennettLancet19744136544Yes
27982214110.5195.7697.9SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. N Guex, M C PeitschElectrophoresis19979504803Yes
280164054101.20.00.0A new and rapid colorimetric determination of acetylcholinesterase activity. G L Ellman, K D Courtney, V Andres, R M Feather-StoneBiochem Pharmacol196113726518Yes
28140964096.099.1999.2Mechanisms of angiogenesis. W RisauNature19979109485No
28240944094.087.387.3The retinoblastoma protein and cell cycle control. R A WeinbergCell19957736585No
283245444090.71048.95174.8MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir KumarMol Biol Evol201121546353Yes
28440904090.0125.23125.2Glutamate neurotoxicity and diseases of the nervous system. D W ChoiNeuron19882908446No
28540734073.00.00.0The determination of enzyme inhibitor constants. M DixonBiochem J195313093635Yes
28640714071.086.9587.0Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. C J MarshallCell19957834738No
28740564056.00.00.0Determination of protein: a modification of the Lowry method that gives a linear photometric response. E F HartreeAnal Biochem19724115981Yes
28840494049.088.7888.8Alternative activation of macrophages. Siamon GordonNat Rev Immunol200312511873No
28940174017.075.6175.6Generalized lacZ expression with the ROSA26 Cre reporter strain. P SorianoNat Genet19999916792Yes
29040024002.080.1780.2The phosphoinositide 3-kinase pathway. Lewis C CantleyScience200212040186No
29139853985.00.00.0Staining of tissue sections for electron microscopy with heavy metals. M L WatsonJ Biophys Biochem Cytol195813563554Yes
29239693969.00.00.0Bone: formation by autoinduction. M R UristScience19655319761Yes
29339583958.0126.53126.5Bacterial evolution. C R WoeseMicrobiol Rev19872439888No
29439483948.0103.47103.5Integrins: a family of cell surface receptors. R O HynesCell19873028640No
29539483948.00.00.0Disc Electrophoresis. I. Background And Theory. L OrnsteinAnn N Y Acad Sci196414240533Yes
29639383938.0121.63121.6How mitochondria produce reactive oxygen species. Michael P MurphyBiochem J200919061483No
29739243924.086.9286.9Wnt/beta-catenin signaling in development and disease. Hans CleversCell200617081971No
29878443922.00.00.0Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. H Aviv, P LederProc Natl Acad Sci U S A19724504350Yes
29939083908.00.00.0The detection of disease clustering and a generalized regression approach. N MantelCancer Res19676018555Yes
30039063906.0129.6129.6Tissue destruction by neutrophils. S J WeissN Engl J Med19892536474No
30138793879.00.00.0Pharmacological implications of microsomal enzyme induction. A H ConneyPharmacol Rev19674383307Yes
30238733873.0160.84160.8An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. Peter C AustinMultivariate Behav Res201121818162Yes
30338723872.0120.74120.7Nitric oxide as a secretory product of mammalian cells. C NathanFASEB J19921381691No
30438633863.0107.48107.5What is the evidence that tumors are angiogenesis dependent? J FolkmanJ Natl Cancer Inst19901688381No
30577093854.50.00.0Functional Evaluation: The Barthel Index. F I Mahoney, D W BarthelMd State Med J196514258950Yes
306115183839.3828.25276.1Cancer statistics, 2016. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201626742998Yes
30776493824.50.00.0Assessment of older people: self-maintaining and instrumental activities of daily living. M P Lawton, E M BrodyGerontologist19695349366Yes
30838223822.087.5387.5PAML: a program package for phylogenetic analysis by maximum likelihood. Z YangComput Appl Biosci19979367129Yes
309113973799.00.00.0Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. W H Habig, M J Pabst, W B JakobyJ Biol Chem19744436300Yes
31075963798.00.00.0Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. D E Paglia, W N ValentineJ Lab Clin Med19676066618Yes
31137743774.080.5380.5A catalogue of splice junction sequences. S M MountNucleic Acids Res19827063411Yes
31237613761.00.00.0New methods for calculating metabolic rate with special reference to protein metabolism. J B De B WeirJ Physiol194915394301Yes
31337593759.085.1185.1Atherosclerosis. A J LusisNature200011001066No
31437583758.0104.76104.8Revisions in the International System for Staging Lung Cancer. C F MountainChest19979187198Yes
31537573757.00.00.0Estimation of the molecular weights of proteins by Sephadex gel-filtration. P AndrewsBiochem J19644158310Yes
31674923746.0185.6292.8Collective dynamics of 'small-world' networks. D J Watts, S H StrogatzNature19989623998Yes
31737413741.00.00.0Preparation of isolated rat liver cells. P O SeglenMethods Cell Biol1976177845No
31837323732.0140.31140.3EuroQol: the current state of play. R BrooksHealth Policy199610158943No
31937303730.0107.98108.0Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. J H MorrisseyAnal Biochem19816172996Yes
32074443722.0220.66110.3Estimating F-Statistics For The Analysis Of Population Structure. B S Weir, C Clark CockerhamEvolution198428563791Yes
32137193719.080.9180.9The green fluorescent protein. R Y TsienAnnu Rev Biochem19989759496No
32274293714.5141.3470.7A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. R S Sikorski, P HieterGenetics19892659436Yes
323111263708.7215.2471.7Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. J D Dignam, R M Lebovitz, R G RoederNucleic Acids Res19836828386Yes
32437033703.00.00.0A membrane-filter technique for the detection of complementary DNA. D T DenhardtBiochem Biophys Res Commun19665963888Yes
32573943697.0179.4989.7MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Jürgen Cox, Matthias MannNat Biotechnol200819029910Yes
32636963696.0131.17131.2Whatever happened to qualitative description? M SandelowskiRes Nurs Health200010940958No
327221433690.5745.44124.2Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C TurnerDiabetologia19853899825Yes
32836833683.0124.89124.9Updating P300: an integrative theory of P3a and P3b. John PolichClin Neurophysiol200717573239No
329110403680.00.00.0Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. J F Kerr, A H Wyllie, A R CurrieBr J Cancer19724561027No
33073213660.5211.66105.8Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. Florian Weigend, Reinhart AhlrichsPhys Chem Chem Phys200516240044Yes
33136593659.00.00.0A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. E PfeifferJ Am Geriatr Soc19751159263Yes
332109763658.7495.25165.1Development and validation of brief measures of positive and negative affect: the PANAS scales. D Watson, L A Clark, A TellegenJ Pers Soc Psychol19883397865Yes
33336533653.091.091.0Multiple sequence alignment with hierarchical clustering. F CorpetNucleic Acids Res19882849754Yes
33436443644.099.1199.1Staphylococcus aureus infections. F D LowyN Engl J Med19989709046No
33536433643.089.5489.5Caspases: the executioners of apoptosis. G M CohenBiochem J19979337844No
33636423642.088.3688.4Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. A T BrüngerNature199218481394Yes
33772763638.0182.6591.3Mitochondria and apoptosis. D R Green, J C ReedScience19989721092No
33836313631.084.5784.6Tandem repeats finder: a program to analyze DNA sequences. G BensonNucleic Acids Res19999862982Yes
33936263626.077.6277.6TGF-beta signal transduction. J MassaguéAnnu Rev Biochem19989759503No
34072333616.50.00.0The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. R C Graham, M J KarnovskyJ Histochem Cytochem19665962951Yes
341144563614.0400.79100.2Global cancer statistics, 2002. D Max Parkin, Freddie Bray, J Ferlay, Paola PisaniCA Cancer J Clin200515761078Yes
34236073607.00.00.0Evolution in Mendelian Populations. S WrightGenetics193117246615Yes
34335973597.091.7191.7Why most published research findings are false. John P A IoannidisPLoS Med200516060722Yes
34435943594.0109.77109.8Inositol trisphosphate and diacylglycerol as second messengers. M J BerridgeBiochem J19846146314No
34535873587.00.00.0Principles that govern the folding of protein chains. C B AnfinsenScience19734124164Yes
34671473573.5288.65144.3Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Kristopher J Preacher, Andrew F HayesBehav Res Methods200818697684Yes
34771263563.0229.85114.9RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. Bo Li, Colin N DeweyBMC Bioinformatics201121816040Yes
34835523552.065.8665.9Somatic generation of antibody diversity. S TonegawaNature19836300689No
349141963549.0420.62105.2Features and development of Coot. P Emsley, B Lohkamp, W G Scott, K CowtanActa Crystallogr D Biol Crystallogr201020383002Yes
35035343534.074.0274.0Hypoxia--a key regulatory factor in tumour growth. Adrian L HarrisNat Rev Cancer200211902584No
35170663533.0251.57125.8DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. P Librado, J RozasBioinformatics200919346325Yes
35235253525.075.9976.0Protein secondary structure prediction based on position-specific scoring matrices. D T JonesJ Mol Biol199910493868Yes
353105683522.7889.63296.5Cancer Statistics, 2017. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201728055103Yes
35435093509.070.8270.8Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. G R MartinProc Natl Acad Sci U S A19816950406Yes
35535063506.082.5882.6Novel proteinaceous infectious particles cause scrapie. S B PrusinerScience19826801762Yes
35635023502.098.7198.7Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. R B D'AgostinoStat Med19989802183Yes
35735023502.00.00.0Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. J CohenPsychol Bull196819673146Yes
35869953497.5132.6566.3Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. A H Brand, N PerrimonDevelopment19938223268Yes
35934963496.098.6798.7Biological roles of oligosaccharides: all of the theories are correct. A VarkiGlycobiology19938490246No
36034923492.0101.99102.0Sequencing technologies - the next generation. Michael L MetzkerNat Rev Genet201019997069No
36134823482.00.00.0Statistical estimations in enzyme kinetics. G N WilkinsonBiochem J196113785321Yes
36234793479.0134.17134.2Measuring the accuracy of diagnostic systems. J A SwetsScience19883287615No
36334793479.084.6884.7Marrow stromal cells as stem cells for nonhematopoietic tissues. D J ProckopScience19979082988No
36434743474.0118.7118.7Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Russell A BarkleyPsychol Bull19979000892No
36534723472.080.5480.5Protein production by auto-induction in high density shaking cultures. F William StudierProtein Expr Purif200515915565Yes
36669403470.00.00.0A new method for sequencing DNA. A M Maxam, W GilbertProc Natl Acad Sci U S A1977265521Yes
36734633463.00.00.0Spectroscopic determination of tryptophan and tyrosine in proteins. H EdelhochBiochemistry19676049437Yes
368173103462.0504.61100.9Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. O P Hamill, A Marty, E Neher, B Sakmann, F J SigworthPflugers Arch19816270629Yes
36969053452.50.00.0Radiological assessment of osteo-arthrosis. J H Kellgren, J S LawrenceAnn Rheum Dis195713498604Yes
37068903445.0156.9378.5Functional rafts in cell membranes. K Simons, E IkonenNature19979177342No
37168883444.0255.9128.0Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. U H Graneheim, B LundmanNurse Educ Today200414769454No
37268843442.0164.1582.1"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. A P Feinberg, B VogelsteinAnal Biochem19846329026Yes
373103193439.7398.54132.8A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. J Ware, M Kosinski, S D KellerMed Care19968628042Yes
37434323432.078.6178.6Instability and decay of the primary structure of DNA. T LindahlNature19938469282No
37534323432.00.00.0The Scree Test For The Number Of Factors. R B CattellMultivariate Behav Res196626828106Yes
37634303430.081.6581.7Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Rakesh K JainScience200515637262No
37768523426.0177.9289.0tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. T M Lowe, S R EddyNucleic Acids Res19979023104Yes
37834163416.00.00.0Generalized expectancies for internal versus external control of reinforcement. J B RotterPsychol Monogr19665340840No
37933923392.00.00.0Basic principles of ROC analysis. C E MetzSemin Nucl Med1978112681Yes
38033923392.070.9871.0Mammalian neural stem cells. F H GageScience200010688783No
381101303376.70.00.0The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. F C Greenwood, W M Hunter, J S GloverBiochem J196314097352Yes
38233753375.00.00.0The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. J F WoessnerArch Biochem Biophys196113786180Yes
38367403370.0207.19103.6BEAST: Bayesian evolutionary analysis by sampling trees. Alexei J Drummond, Andrew RambautBMC Evol Biol200717996036Yes
38467263363.0289.62144.8The timed "Up & Go": a test of basic functional mobility for frail elderly persons. D Podsiadlo, S RichardsonJ Am Geriatr Soc19911991946Yes
38533443344.0103.07103.1Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. L R SquirePsychol Rev19921594723No
38633413341.083.6783.7The heat-shock response. S LindquistAnnu Rev Biochem19862427013No
387100233341.01132.26377.4Cancer statistics, 2018. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201829313949Yes
38866723336.0173.5286.8TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. T R Mosmann, R L CoffmanAnnu Rev Immunol19892523712No
38933283328.077.3977.4Scaling and assessment of data quality. Philip EvansActa Crystallogr D Biol Crystallogr200616369096No
39033273327.068.8968.9Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. M KozakNucleic Acids Res19846694911Yes
39199613320.3465.85155.3Cancer statistics, 2013. Rebecca Siegel, Deepa Naishadham, Ahmedin JemalCA Cancer J Clin201323335087Yes
39233203320.078.8578.8The dendritic cell system and its role in immunogenicity. R M SteinmanAnnu Rev Immunol19911910679No
39366363318.0177.7488.9Control of goal-directed and stimulus-driven attention in the brain. Maurizio Corbetta, Gordon L ShulmanNat Rev Neurosci200211994752No
39433173317.088.5788.6Microglia: a sensor for pathological events in the CNS. G W KreutzbergTrends Neurosci19968843599No
39533153315.0100.26100.3What's wrong with Bonferroni adjustments. T V PernegerBMJ19989553006No
39666273313.5193.0896.5Ab initio molecular dynamics for liquid metals. Kresse, HafnerPhys Rev B Condens Matter199310004490Yes
39733123312.068.9669.0The scanning model for translation: an update. M KozakJ Cell Biol19892645293No
39833123312.00.00.0Equilibrium Ultracentrifugation Of Dilute Solutions. D A YphantisBiochemistry196414155091Yes
39933043304.00.00.0Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. J D RowleyNature19734126434Yes
40033033303.0111.14111.1Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. Ilan H MeyerPsychol Bull200312956539No
40132993299.084.7284.7Gene regulation by steroid hormones. M BeatoCell19892644044No
40232983298.065.365.3Signal transduction by the JNK group of MAP kinases. R J DavisCell200011057897No
40332923292.0100.24100.2Protective and damaging effects of stress mediators. B S McEwenN Engl J Med19989428819No
40432893289.092.392.3Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. R W MahleyScience19883283935No
40532803280.00.00.0Some factors in the interpretation of protein denaturation. W KauzmannAdv Protein Chem195914404936Yes
40632763276.0113.96114.0genepop'007: a complete re-implementation of the genepop software for Windows and Linux. François RoussetMol Ecol Resour200821585727Yes
40798143271.3420.49140.2Cancer statistics, 2012. Rebecca Siegel, Deepa Naishadham, Ahmedin JemalCA Cancer J Clin201222237781Yes
40832673267.0116.34116.3How do you feel--now? The anterior insula and human awareness. A D Bud CraigNat Rev Neurosci200919096369No
40932643264.0129.59129.6A concordance correlation coefficient to evaluate reproducibility. L I LinBiometrics19892720055Yes
410130423260.5305.5476.4Improved methods for building protein models in electron density maps and the location of errors in these models. T A Jones, J Y Zou, S W Cowan, M KjeldgaardActa Crystallogr A19912025413Yes
41165113255.5124.2662.1Translating the histone code. T Jenuwein, C D AllisScience200111498575No
41232543254.084.6884.7Biologic basis for interleukin-1 in disease. C A DinarelloBlood19968630372No
41332513251.00.00.0Observational study of behavior: sampling methods. J AltmannBehaviour19744597405No
41464963248.0249.01124.5The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. I F Benzie, J J StrainAnal Biochem19968660627Yes
41564563228.00.00.0Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. D H Hubel, T N WieselJ Physiol196214449617Yes
41632263226.088.2388.2The adolescent brain and age-related behavioral manifestations. L P SpearNeurosci Biobehav Rev200010817843No
41732253225.00.00.0Estimation of average heterozygosity and genetic distance from a small number of individuals. M NeiGenetics197817248844Yes
41832243224.0128.89128.9Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. O W GriffithAnal Biochem19807416462Yes
41964323216.02067.081033.5Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. Zunyou Wu, Jennifer M McGooganJAMA202032091533Yes
42032103210.093.1193.1Inositol trisphosphate and diacylglycerol: two interacting second messengers. M J BerridgeAnnu Rev Biochem19873304132No
42132003200.097.4197.4Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. VanderbiltPhys Rev B Condens Matter19909993096Yes
42232003200.088.4688.5Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Kim A BrogdenNat Rev Microbiol200515703760No
42331943194.077.1877.2Glutamate uptake. N C DanboltProg Neurobiol200111369436No
42431933193.077.2277.2Nonalcoholic fatty liver disease. Paul AnguloN Engl J Med200211961152No
425127693192.2544.85136.2Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanAnn Intern Med200919622511No
42695593186.3575.58191.9Cancer statistics, 2015. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201525559415Yes
42731823182.084.5584.5Oxidative stress, antioxidants and stress tolerance. Ron MittlerTrends Plant Sci200212234732No
42831783178.00.00.0Diffusion-in-gel methods for immunological analysis. O OuchterlonyProg Allergy195813578996Yes
42963423171.0166.5883.3An integrative theory of prefrontal cortex function. E K Miller, J D CohenAnnu Rev Neurosci200111283309No
43031623162.079.4979.5The transforming growth factor-beta family. J MassaguéAnnu Rev Cell Biol19902177343No
43131573157.068.3968.4Profile hidden Markov models. S R EddyBioinformatics19989918945No
43294613153.7315.63105.2Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. E R DeLong, D M DeLong, D L Clarke-PearsonBiometrics19883203132Yes
43331513151.00.00.0Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. S W KesslerJ Immunol19751102604Yes
43431413141.085.4185.4ABC transporters: from microorganisms to man. C F HigginsAnnu Rev Cell Biol19921282354No
43531373137.073.7873.8Tolerance, danger, and the extended family. P MatzingerAnnu Rev Immunol19948011301No
43631373137.00.00.0The magical number seven plus or minus two: some limits on our capacity for processing information. G A MillerPsychol Rev195613310704Yes
43731333133.084.5584.5I-TASSER server for protein 3D structure prediction. Yang ZhangBMC Bioinformatics200818215316Yes
43831213121.00.00.0Notes on sugar determination. M SmogyiJ Biol Chem195214938350Yes
439187203120.01164.76194.1Global cancer statistics, 2012. Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin JemalCA Cancer J Clin201525651787Yes
44093593119.7390.62130.2A global measure of perceived stress. S Cohen, T Kamarck, R MermelsteinJ Health Soc Behav19836668417Yes
44131193119.0100.92100.9Graphene: status and prospects. A K GeimScience200919541989Yes
442124753118.8327.481.8Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Ben Langmead, Cole Trapnell, Mihai Pop, Steven L SalzbergGenome Biol200919261174Yes
44331123112.0104.55104.5Modeling valuations for EuroQol health states. P DolanMed Care19979366889Yes
44493323110.71600.99533.7Cancer statistics, 2019. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201930620402Yes
44562123106.00.00.0Microsomal lipid peroxidation. J A Buege, S D AustMethods Enzymol1978672633Yes
44631003100.085.785.7The origins and the future of microfluidics. George M WhitesidesNature200616871203No
44730793079.064.1164.1CpG-rich islands and the function of DNA methylation. A P BirdNature19862423876No
44861383069.0186.7393.4Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Daniel R Zerbino, Ewan BirneyGenome Res200818349386Yes
44930653065.062.5162.5STATs and gene regulation. J E DarnellScience19979287210No
45030633063.069.0869.1Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. H F DvorakN Engl J Med19863537791No
45130633063.058.7958.8Cell signaling by receptor tyrosine kinases. J SchlessingerCell200011057895No
45261213060.50.00.0Human malaria parasites in continuous culture. W Trager, J B JensenScience1976781840Yes
45330513051.072.8772.9WHAT IF: a molecular modeling and drug design program. G VriendJ Mol Graph19902268628Yes
45430493049.073.4173.4Folding DNA to create nanoscale shapes and patterns. Paul W K RothemundNature200616541064Yes
45560963048.0121.2760.6The ubiquitin system. A Hershko, A CiechanoverAnnu Rev Biochem19989759494No
45660933046.5155.8577.9WGCNA: an R package for weighted correlation network analysis. Peter Langfelder, Steve HorvathBMC Bioinformatics200819114008Yes
45730413041.068.068.0Activators and target genes of Rel/NF-kappaB transcription factors. H L PahlOncogene199910602461No
45890903030.0312.73104.2Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. R M Palmer, A G Ferrige, S MoncadaNature19873495737Yes
45960453022.5128.064.0Statistical significance for genomewide studies. John D Storey, Robert TibshiraniProc Natl Acad Sci U S A200312883005Yes
46060423021.0136.1568.1Angiogenesis in cancer and other diseases. P Carmeliet, R K JainNature200011001068No
46130193019.00.00.0Towards a network theory of the immune system. N K JerneAnn Immunol (Paris)19744142565No
46260143007.0170.7385.4The basics of epithelial-mesenchymal transition. Raghu Kalluri, Robert A WeinbergJ Clin Invest200919487818No
46329982998.00.00.0A study of fixation for electron microscopy. G E PaladeJ Exp Med195214927794Yes
46429932993.070.5170.5Cadherin cell adhesion receptors as a morphogenetic regulator. M TakeichiScience19912006419No
46529932993.074.2274.2Neural networks and physical systems with emergent collective computational abilities. J J HopfieldProc Natl Acad Sci U S A19826953413Yes
46629902990.074.4874.5Wound healing--aiming for perfect skin regeneration. P MartinScience19979082989No
46729862986.097.8597.8Emerging adulthood. A theory of development from the late teens through the twenties. J J ArnettAm Psychol200010842426Yes
46829832983.074.6574.7Photoelectrochemical cells. M GrätzelNature200111713540Yes
46929742974.00.00.0A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. S HakomoriJ Biochem196414135466Yes
47059402970.0232.57116.3Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Laurent Excoffier, Heidi E L LischerMol Ecol Resour201021565059Yes
47129682968.00.00.0The gel-filtration behaviour of proteins related to their molecular weights over a wide range. P AndrewsBiochem J19655862401Yes
47229612961.086.3486.3EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. W KlimeschBrain Res Brain Res Rev199910209231No
47329602960.082.9783.0Hay fever, hygiene, and household size. D P StrachanBMJ19892513902Yes
47429542954.076.1676.2The basis of anisotropic water diffusion in the nervous system - a technical review. Christian BeaulieuNMR Biomed200212489094No
47558982949.0124.9662.5Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. D B Smith, K S JohnsonGene19883047011Yes
47629452945.079.1979.2The pathobiology of diabetic complications: a unifying mechanism. Michael BrownleeDiabetes200515919781No
47758762938.0145.0972.5Inference of macromolecular assemblies from crystalline state. Evgeny Krissinel, Kim HenrickJ Mol Biol200717681537Yes
47829352935.072.8272.8Phase separation of integral membrane proteins in Triton X-114 solution. C BordierJ Biol Chem19816257680Yes
47929342934.00.00.0Gene action in the X-chromosome of the mouse (Mus musculus L.). M F LyonNature196113764598Yes
48029332933.00.00.0Transformed up-down methods in psychoacoustics. H LevittJ Acoust Soc Am19715541744Yes
481205202931.4483.1969.0UCSF Chimera--a visualization system for exploratory research and analysis. Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E FerrinJ Comput Chem200415264254Yes
48229172917.064.7764.8Mechanisms of angiogenesis and arteriogenesis. P CarmelietNat Med200010742145No
48329102910.091.0591.0Matrix metalloproteinases and their inhibitors in connective tissue remodeling. J F WoessnerFASEB J19911850705No
48429052905.00.00.0Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. W C SchneiderJ Biol Chem194521005736Yes
48529042904.098.0898.1Functions of DNA methylation: islands, start sites, gene bodies and beyond. Peter A JonesNat Rev Genet201222641018No
48629022902.00.00.0Catheter replacement of the needle in percutaneous arteriography; a new technique. S I SeldingerActa radiol195313057644Yes
48787042901.3243.4281.1Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Y Gavrieli, Y Sherman, S A Ben-SassonJ Cell Biol19921400587Yes
48886772892.3180.5160.2Significance analysis of microarrays applied to the ionizing radiation response. V G Tusher, R Tibshirani, G ChuProc Natl Acad Sci U S A200111309499Yes
48928872887.069.8269.8Chemokines--chemotactic cytokines that mediate inflammation. A D LusterN Engl J Med19989459648No
49028842884.064.9865.0Angiogenesis in health and disease. Peter CarmelietNat Med200312778163No
49128832883.075.675.6How do you feel? Interoception: the sense of the physiological condition of the body. A D CraigNat Rev Neurosci200212154366No
49228832883.060.9360.9The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Isaiah J FidlerNat Rev Cancer200312778135No
49328812881.0165.66165.7Executive functions. Adele DiamondAnnu Rev Psychol201323020641No
49457552877.5228.54114.3Management of hepatocellular carcinoma: an update. Jordi Bruix, Morris ShermanHepatology201121374666No
49528702870.051.3451.3One-step gene disruption in yeast. R J RothsteinMethods Enzymol19836310324Yes
49685962865.30.00.0The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. R J Havel, H A Eder, J H BragdonJ Clin Invest195513252080Yes
49757292864.5163.0681.5Inositol trisphosphate, a novel second messenger in cellular signal transduction. M J Berridge, R F IrvineNature19846095092No
49828632863.079.4279.4Mesenchymal stem cells. A I CaplanJ Orthop Res19911870029Yes
49928592859.00.00.0Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. B E MurphyJ Clin Endocrinol Metab19674291524Yes
50028592859.0118.04118.0Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. T E MoffittPsychol Rev19938255953No
50128592859.090.1890.2Development of a classification system for periodontal diseases and conditions. G C ArmitageAnn Periodontol199910863370No
50228562856.00.00.0Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. L SvennerholmBiochim Biophys Acta195713436486Yes
50357102855.0138.169.0Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. C Tuerk, L GoldScience19902200121Yes
50428552855.063.4663.5Protein folding and misfolding. Christopher M DobsonNature200314685248No
50557042852.0129.1764.6Toll-like receptor signalling. Shizuo Akira, Kiyoshi TakedaNat Rev Immunol200415229469No
50628502850.072.8572.8Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Ting-Chao ChouPharmacol Rev200616968952No
50785432847.7190.2463.4Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Benjamin P Lewis, Christopher B Burge, David P BartelCell200515652477Yes
50885412847.00.00.0Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. G Fairbanks, T L Steck, D F WallachBiochemistry19714326772Yes
50928472847.061.9161.9Alzheimer's disease is a synaptic failure. Dennis J SelkoeScience200212399581No
51056812840.50.00.0Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Glowinski, L L IversenJ Neurochem19665950056Yes
51156732836.5146.8673.4The plant immune system. Jonathan D G Jones, Jeffery L DanglNature200617108957No
51228352835.084.1284.1Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. Thomas WeltonChem Rev199911849019Yes
51356622831.00.00.0Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. C Beauchamp, I FridovichAnal Biochem19714943714Yes
51428302830.0110.86110.9Half a century of research on the Stroop effect: an integrative review. C M MacLeodPsychol Bull19912034749No
51528302830.092.9693.0An empirical correction for absorption anisotropy. R H BlessingActa Crystallogr A19957702794Yes
51656572828.5135.5967.8MicroRNA signatures in human cancers. George A Calin, Carlo M CroceNat Rev Cancer200617060945No
51784562818.7228.8776.3Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Da Wei Huang, Brad T Sherman, Richard A LempickiNucleic Acids Res200919033363Yes
51828172817.00.00.0A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. E A GehanBiometrika196514341275Yes
51928162816.055.055.0RNA interference. Gregory J HannonNature200212110901No
52056262813.00.00.0A method for determining the sedimentation behavior of enzymes: application to protein mixtures. R G Martin, B N AmesJ Biol Chem196113767412Yes
52128112811.00.00.0A study of the adrenotropic receptors. R P AhlquistAm J Physiol194818882199Yes
522112402810.0454.33113.6APACHE II: a severity of disease classification system. W A Knaus, E A Draper, D P Wagner, J E ZimmermanCrit Care Med19853928249Yes
52356162808.0164.5582.3Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. S Duval, R TweedieBiometrics200010877304Yes
52456092804.5103.5651.8The language of covalent histone modifications. B D Strahl, C D AllisNature200010638745Yes
52528012801.059.4959.5Principles of CDK regulation. D O MorganNature19957877684No
52627902790.092.8192.8Health promotion by social cognitive means. Albert BanduraHealth Educ Behav200415090118Yes
52727892789.094.394.3Role of oxidative stress in development of complications in diabetes. J W BaynesDiabetes19912010041No
52855782789.0153.276.6The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. J Vieira, J MessingGene19826295879Yes
52955752787.50.00.0Pain mechanisms: a new theory. R Melzack, P D WallScience19655320816No
530111472786.80.00.0Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. P W Rigby, M Dieckmann, C Rhodes, P BergJ Mol Biol1977881736Yes
53155692784.50.00.0Assessment of outcome after severe brain damage. B Jennett, M BondLancet197546957Yes
532111332783.2281.8170.5Haploview: analysis and visualization of LD and haplotype maps. J C Barrett, B Fry, J Maller, M J DalyBioinformatics200515297300Yes
53355612780.5110.8255.4High-efficiency transformation of mammalian cells by plasmid DNA. C Chen, H OkayamaMol Cell Biol19873670292Yes
53455512775.50.00.0A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. S Reitman, S FrankelAm J Clin Pathol195713458125Yes
53527752775.068.7768.8Obesity as a medical problem. P G KopelmanNature200010766250No
53627712771.00.00.0Efficient trace-labelling of proteins with iodine. A S McFARLANENature195813566175Yes
53755312765.5146.2773.1Voxel-based morphometry--the methods. J Ashburner, K J FristonNeuroimage200010860804No
53882852761.7179.6359.9Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. C M Gorman, L F Moffat, B H HowardMol Cell Biol19826960240Yes
53955212760.50.00.0The fluid mosaic model of the structure of cell membranes. S J Singer, G L NicolsonScience19724333397Yes
54027462746.00.00.0Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. P CuatrecasasJ Biol Chem19705432796Yes
54154872743.5162.3181.2Projections of global mortality and burden of disease from 2002 to 2030. Colin D Mathers, Dejan LoncarPLoS Med200617132052Yes
54227392739.084.1384.1Implications of normal brain development for the pathogenesis of schizophrenia. D R WeinbergerArch Gen Psychiatry19873606332Yes
54327352735.096.6796.7The processing-speed theory of adult age differences in cognition. T A SalthousePsychol Rev19968759042No
54427342734.083.3683.4Drug combination studies and their synergy quantification using the Chou-Talalay method. Ting-Chao ChouCancer Res201020068163Yes
54527332733.0126.89126.9The quality of care. How can it be assessed? A DonabedianJAMA19883045356No
54627312731.092.0292.0Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Sarah E BarlowPediatrics200718055651Yes
54754612730.5243.85121.9Revised methods for the Salmonella mutagenicity test. D M Maron, B N AmesMutat Res19836341825Yes
54827302730.00.00.0Measurement of pain. E C HuskissonLancet19744139420Yes
54981862728.7394.05131.3HTSeq--a Python framework to work with high-throughput sequencing data. Simon Anders, Paul Theodor Pyl, Wolfgang HuberBioinformatics201525260700Yes
55027222722.092.6392.6Hepatocellular carcinoma. Hashem B El-SeragN Engl J Med201121992124No
55127202720.060.7760.8Cardiac excitation-contraction coupling. Donald M BersNature200211805843No
55254342717.0127.9264.0Caspases: enemies within. N A Thornberry, Y LazebnikScience19989721091No
55354332716.50.00.0The serial cultivation of human diploid cell strains. L Hayflick, P S MoorheadExp Cell Res196113905658Yes
55454282714.0131.9766.0Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. T C Chou, P TalalayAdv Enzyme Regul19846382953Yes
55527122712.066.4266.4Cell death during development of the nervous system. R W OppenheimAnnu Rev Neurosci19912031577No
55627052705.072.8972.9Recent advances with liposomes as pharmaceutical carriers. Vladimir P TorchilinNat Rev Drug Discov200515688077No
55727012701.061.0661.1Inflammatory bowel disease. Daniel K PodolskyN Engl J Med200212167685No
55827012701.084.4884.5Non-coding RNAs in human disease. Manel EstellerNat Rev Genet201122094949No
55926992699.056.6456.6Toll-like receptors and innate immunity. R MedzhitovNat Rev Immunol200111905821No
56026982698.071.6271.6Optimal two-stage designs for phase II clinical trials. R SimonControl Clin Trials19892702835Yes
56180882696.0213.4971.2MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Sudhir Kumar, Koichiro Tamura, Masatoshi NeiBrief Bioinform200415260895Yes
56226932693.065.3765.4Mitochondrial formation of reactive oxygen species. Julio F TurrensJ Physiol200314561818No
56326932693.073.073.0Origin and physiological roles of inflammation. Ruslan MedzhitovNature200818650913No
564107692692.2376.3994.1Cancer statistics, 2010. Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth WardCA Cancer J Clin201020610543Yes
56526832683.064.3964.4Structure and function of telomeres. E H BlackburnNature19911708110No
56626792679.064.1264.1Molecular chaperones in cellular protein folding. F U HartlNature19968637592No
56753582679.00.00.0A modified uronic acid carbazole reaction. T Bitter, H M MuirAnal Biochem196213971270Yes
56826732673.052.3652.4Genome maintenance mechanisms for preventing cancer. J H HoeijmakersNature200111357144No
56953452672.5127.363.6Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. F W Studier, B A MoffattJ Mol Biol19863537305Yes
57026712671.076.9577.0Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. Y X FuGenetics19979335623Yes
57153362668.0174.6187.3Tissue engineering. R Langer, J P VacantiScience19938493529No
57253212660.5126.4663.2Oncomirs - microRNAs with a role in cancer. Aurora Esquela-Kerscher, Frank J SlackNat Rev Cancer200616557279No
57326562656.00.00.0Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. P MitchellNature196113771349Yes
57453102655.0132.2566.1In vitro selection of RNA molecules that bind specific ligands. A D Ellington, J W SzostakNature19901697402Yes
57526552655.052.2852.3Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. P SchuckBiophys J200010692345Yes
57626502650.0124.54124.5The short-form McGill Pain Questionnaire. Ronald MelzackPain19873670870Yes
57726492649.086.5586.5Psychometric properties of the strengths and difficulties questionnaire. R GoodmanJ Am Acad Child Adolesc Psychiatry200111699809Yes
578105842646.0441.53110.4Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanBMJ200919622551No
57952842642.0148.574.2Fast and accurate long-read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics201020080505Yes
58079182639.3205.3168.4TopHat: discovering splice junctions with RNA-Seq. Cole Trapnell, Lior Pachter, Steven L SalzbergBioinformatics200919289445Yes
58152652632.5132.5266.3Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. D Hanahan, J FolkmanCell19968756718No
58226322632.00.00.0Stereotaxic mapping of the monoamine pathways in the rat brain. U UngerstedtActa Physiol Scand Suppl19714109331Yes
58352592629.5164.482.2Glutathione. A Meister, M E AndersonAnnu Rev Biochem19836137189No
58452532626.5123.4261.7Oxidants, oxidative stress and the biology of ageing. T Finkel, N J HolbrookNature200011089981No
58526262626.00.00.0A gene complex controlling segmentation in Drosophila. E B LewisNature1978103000Yes
58626252625.081.6881.7Primate models of movement disorders of basal ganglia origin. M R DeLongTrends Neurosci19901695404No
58726242624.049.3149.3Wnt signaling and cancer. P PolakisGenes Dev200010921899No
58826242624.00.00.0The genetical structure of populations. S WrightAnn Eugen195124540312Yes
58952422621.0180.6590.3Measuring agreement in method comparison studies. J M Bland, D G AltmanStat Methods Med Res199910501650No
59052422621.00.00.0Some quantitative uses of drug antagonists. O Arunlakshana, H O SchildBr J Pharmacol Chemother195913651579Yes
59126182618.00.00.0A simple technique for demonstrating centromeric heterochromatin. A T SumnerExp Cell Res19724117921Yes
592157002616.7635.34105.9Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G CondeJ Biomed Inform200918929686Yes
593104202605.0230.2357.6Cluster analysis and display of genome-wide expression patterns. M B Eisen, P T Spellman, P O Brown, D BotsteinProc Natl Acad Sci U S A19989843981Yes
59426042604.081.7981.8Estimation of metabolite concentrations from localized in vivo proton NMR spectra. S W ProvencherMagn Reson Med19938139448Yes
59551932596.5182.8791.4A simple, rapid, and sensitive DNA assay procedure. C Labarca, K PaigenAnal Biochem19806158890Yes
59625962596.061.9261.9TGFbeta in Cancer. Joan MassaguéCell200818662538No
59725942594.00.00.0The membrane actions of anesthetics and tranquilizers. P SeemanPharmacol Rev19724565956No
59825942594.060.1560.1Nuclear factor-kappaB in cancer development and progression. Michael KarinNature200616724054No
599129612592.2524.5104.9The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. D J Buysse, C F Reynolds, T H Monk, S R Berman, D J KupferPsychiatry Res19892748771Yes
60025882588.082.6382.6Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. B SamuelssonScience19836301011Yes
60177422580.7216.3372.1Understanding the Warburg effect: the metabolic requirements of cell proliferation. Matthew G Vander Heiden, Lewis C Cantley, Craig B ThompsonScience200919460998No
60225782578.085.285.2No adjustments are needed for multiple comparisons. K J RothmanEpidemiology19902081237Yes
60351562578.0186.593.2A method of comparing the areas under receiver operating characteristic curves derived from the same cases. J A Hanley, B J McNeilRadiology19836878708Yes
60477312577.0261.4287.1Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. R A Deyo, D C Cherkin, M A CiolJ Clin Epidemiol19921607900Yes
60551532576.5117.0758.5Signal transduction by receptors with tyrosine kinase activity. A Ullrich, J SchlessingerCell19902158859No
606231872576.3657.0973.0The Sequence Alignment/Map format and SAMtools. Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard DurbinBioinformatics200919505943Yes
60751482574.0106.3853.2Establishment in culture of pluripotential cells from mouse embryos. M J Evans, M H KaufmanNature19817242681Yes
60825732573.00.00.0Analysis of gene diversity in subdivided populations. M NeiProc Natl Acad Sci U S A19734519626Yes
60925702570.045.7845.8Mechanisms underlying ubiquitination. C M PickartAnnu Rev Biochem200111395416No
61025662566.00.00.0The biology of oxygen radicals. I FridovichScience1978210504Yes
61151322566.0189.9595.0Longitudinal data analysis for discrete and continuous outcomes. S L Zeger, K Y LiangBiometrics19863719049Yes
61225662566.059.5859.6Cell adhesion: the molecular basis of tissue architecture and morphogenesis. B M GumbinerCell19968608588No
61325652565.00.00.0The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. R R PorterBiochem J195914434282Yes
61425652565.089.4689.5Essential oils: their antibacterial properties and potential applications in foods--a review. Sara BurtInt J Food Microbiol200415246235No
61525642564.054.2254.2Papillomaviruses and cancer: from basic studies to clinical application. Harald zur HausenNat Rev Cancer200212044010No
61625622562.064.4164.4The nerve growth factor 35 years later. R Levi-MontalciniScience19873306916No
61725602560.060.0860.1Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. S A BustinJ Mol Endocrinol200011013345No
61825552555.00.00.0Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. O SmithiesBiochem J195513276348Yes
61951092554.50.00.0Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. L A Greene, A S TischlerProc Natl Acad Sci U S A19761065897Yes
62025512551.0119.88119.9Detecting alcoholism. The CAGE questionnaire. J A EwingJAMA19846471323Yes
62125512551.053.6553.6Interleukin-12 and the regulation of innate resistance and adaptive immunity. Giorgio TrinchieriNat Rev Immunol200312563297No
62225512551.052.5652.6Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Shimon SakaguchiAnnu Rev Immunol200415032588No
62350902545.0112.6756.3Emergence of scaling in random networks Barabasi, AlbertScience199910521342Yes
62425402540.062.5762.6Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. E C ButcherCell19911760836No
62525402540.055.3155.3G1 phase progression: cycling on cue. C J SherrCell19947954821No
62625392539.052.852.8The danger model: a renewed sense of self. Polly MatzingerScience200211951032Yes
62725342534.072.6372.6Delayed neuronal death in the gerbil hippocampus following ischemia. T KirinoBrain Res19827093691Yes
62825282528.067.2967.3The resurgence of platinum-based cancer chemotherapy. Lloyd KellandNat Rev Cancer200717625587No
62925262526.080.7580.8What are the functional consequences of neurocognitive deficits in schizophrenia? M F GreenAm J Psychiatry19968610818No
63075682522.7296.2598.8Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Allison Tong, Peter Sainsbury, Jonathan CraigInt J Qual Health Care200717872937Yes
63125182518.0110.87110.9FreeSurfer. Bruce FischlNeuroimage201222248573No
63250332516.5174.9487.5mTOR signaling in growth control and disease. Mathieu Laplante, David M SabatiniCell201222500797No
63350252512.50.00.0Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. J Sedlak, R H LindsayAnal Biochem19684973948Yes
634100502512.5372.0293.0A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge KriegJ Chem Phys201020423165Yes
63550242512.0157.8878.9Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. K Tamura, M NeiMol Biol Evol19938336541Yes
63675242508.0173.3457.8The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. R C Lee, R L Feinbaum, V AmbrosCell19938252621Yes
63725072507.077.7377.7Secretory products of macrophages. C F NathanJ Clin Invest19873543052No
63850142507.0105.3552.7Innate immune recognition. Charles A Janeway, Ruslan MedzhitovAnnu Rev Immunol200211861602No
63950132506.5151.8975.9The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Taro Kawai, Shizuo AkiraNat Immunol201020404851No
64025012501.067.5567.5Predictive reward signal of dopamine neurons. W SchultzJ Neurophysiol19989658025No
64149992499.5158.7479.4The L-arginine-nitric oxide pathway. S Moncada, A HiggsN Engl J Med19937504210No
64224972497.00.00.0Elastic properties of lipid bilayers: theory and possible experiments. W HelfrichZ Naturforsch C19734273690Yes
64349922496.0177.8488.9The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Stephen B Edge, Carolyn C ComptonAnn Surg Oncol201020180029No
64449862493.00.00.0The Social Readjustment Rating Scale. T H Holmes, R H RaheJ Psychosom Res19676059863Yes
64549822491.00.00.0Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. P J Fraker, J C SpeckBiochem Biophys Res Commun1978637870Yes
64649772488.50.00.0A diagnostic interview: the schedule for affective disorders and schizophrenia. J Endicott, R L SpitzerArch Gen Psychiatry1978678037Yes
64724882488.050.7750.8Universal control mechanism regulating onset of M-phase. P NurseNature19902138713No
64824882488.060.3660.4Memory--a century of consolidation. J L McGaughScience200010634773No
64949762488.0172.086.0Computed tomography--an increasing source of radiation exposure. David J Brenner, Eric J HallN Engl J Med200718046031No
65024842484.00.00.0On the number of segregating sites in genetical models without recombination. G A WattersonTheor Popul Biol19751145509Yes
65124792479.00.00.0The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. M L AnsonJ Gen Physiol193819873094Yes
652198222477.8451.5556.4The Protein Data Bank. H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E BourneNucleic Acids Res200010592235Yes
65324752475.00.00.0Oxygen-dependent microbial killing by phagocytes (first of two parts). B M BabiorN Engl J Med197824176Yes
65449492474.5133.7266.9Exploring the full spectrum of macrophage activation. David M Mosser, Justin P EdwardsNat Rev Immunol200819029990No
65524682468.00.00.0The catecholamine hypothesis of affective disorders: a review of supporting evidence. J J SchildkrautAm J Psychiatry19655319766No
65624622462.00.00.0Models for the specific adhesion of cells to cells. G I BellScience1978347575No
65724612461.00.00.0The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. S BoydenJ Exp Med196213872176Yes
65824572457.058.3658.4Prostaglandins and leukotrienes: advances in eicosanoid biology. C D FunkScience200111729303No
65973352445.0222.5774.2Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. G Evanno, S Regnaut, J GoudetMol Ecol200515969739Yes
66097742443.5303.876.0Establishing a standard definition for child overweight and obesity worldwide: international survey. T J Cole, M C Bellizzi, K M Flegal, W H DietzBMJ200010797032Yes
66148842442.0108.9754.5Inflammation and cancer: back to Virchow? F Balkwill, A MantovaniLancet200111229684No
66224312431.055.3255.3Social controls on cell survival and cell death. M C RaffNature19921557121No
66348492424.5197.3698.7A feature-integration theory of attention. A M Treisman, G GeladeCogn Psychol19807351125Yes
66424212421.093.7293.7Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. Joseph P WeirJ Strength Cond Res200515705040No
66524202420.089.0689.1Measures of reliability in sports medicine and science. W G HopkinsSports Med200010907753Yes
66648332416.5146.1573.1Adherence to medication. Lars Osterberg, Terrence BlaschkeN Engl J Med200516079372No
66748302415.0157.9179.0Complex brain networks: graph theoretical analysis of structural and functional systems. Ed Bullmore, Olaf SpornsNat Rev Neurosci200919190637No
66824142414.068.2968.3Cellular and molecular mechanisms of fibrosis. T A WynnJ Pathol200818161745No
66924112411.063.8663.9The genetic legacy of the Quaternary ice ages. G HewittNature200010879524No
67024082408.065.7765.8Dominant forces in protein folding. K A DillBiochemistry19902207096No
67124082408.054.4454.4Bone resorption by osteoclasts. S L TeitelbaumScience200010968780No
67224052405.00.00.0Perceived exertion as an indicator of somatic stress. G BorgScand J Rehabil Med19705523831Yes
67324032403.00.00.0Transduction of linked genetic characters of the host by bacteriophage P1. E S LennoxVirology195513267987Yes
67448052402.50.00.0Electrochemical photolysis of water at a semiconductor electrode. A Fujishima, K HondaNature197212635268Yes
67523992399.092.9492.9You want to measure coping but your protocol's too long: consider the brief COPE. C S CarverInt J Behav Med199716250744Yes
67647802390.00.00.0Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. J V Durnin, J WomersleyBr J Nutr19744843734Yes
67747782389.0116.1258.1Calculation of protein extinction coefficients from amino acid sequence data. S C Gill, P H von HippelAnal Biochem19892610349Yes
67823872387.065.4765.5Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. H G GratznerScience19827123245Yes
67923872387.00.00.0Satellite cell of skeletal muscle fibers. A MauroJ Biophys Biochem Cytol196113768451Yes
68023762376.00.00.0Colorimetric assay of catalase. A K SinhaAnal Biochem19724556490Yes
68171272375.7177.459.1Pathogen recognition and innate immunity. Shizuo Akira, Satoshi Uematsu, Osamu TakeuchiCell200616497588No
68223732373.057.9658.0Autophagy: process and function. Noboru MizushimaGenes Dev200718006683No
68347402370.0157.5978.8The neural basis of drug craving: an incentive-sensitization theory of addiction. T E Robinson, K C BerridgeBrain Res Brain Res Rev19938401595No
68423682368.00.00.0Electroimmuno assay. C B LaurellScand J Clin Lab Invest Suppl19724114358Yes
68523682368.057.7657.8Vascular endothelial growth factor: basic science and clinical progress. Napoleone FerraraEndocr Rev200415294883No
68623642364.00.00.0A rapid radiochemical method for the determination of choline acetyltransferase. F FonnumJ Neurochem19751113118Yes
68747282364.0134.6267.3Unified segmentation. John Ashburner, Karl J FristonNeuroimage200515955494Yes
68894562364.0491.74122.9Cancer statistics, 2014. Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin JemalCA Cancer J Clin201424399786Yes
68947232361.597.3848.7Untangling the ErbB signalling network. Y Yarden, M X SliwkowskiNat Rev Mol Cell Biol200111252954No
69047202360.00.00.0Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. S Marklund, G MarklundEur J Biochem19744215654Yes
69147132356.594.9147.5CDK inhibitors: positive and negative regulators of G1-phase progression. C J Sherr, J M RobertsGenes Dev199910385618No
69223512351.057.757.7Epigenetics in cancer. Manel EstellerN Engl J Med200818337604No
69323482348.061.4861.5Cancer nanotechnology: opportunities and challenges. Mauro FerrariNat Rev Cancer200515738981No
69446952347.50.00.0Screening lambdagt recombinant clones by hybridization to single plaques in situ. W D Benton, R W DavisScience1977322279Yes
69546932346.50.00.0A general method applicable to the search for similarities in the amino acid sequence of two proteins. S B Needleman, C D WunschJ Mol Biol19705420325Yes
69623392339.056.3456.3Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. G P SmithScience19854001944Yes
69723362336.00.00.0The glomerular permeability determined by dextran clearance using Sephadex gel filtration. C E MogensenScand J Clin Lab Invest19685637478Yes
69823362336.072.0472.0RELION: implementation of a Bayesian approach to cryo-EM structure determination. Sjors H W ScheresJ Struct Biol201223000701Yes
69946562328.00.00.0Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. R A Laskey, A D MillsEur J Biochem19751175627Yes
70046562328.00.00.0Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. J D Watson, F H CrickNature195313054692Yes
70123262326.054.1154.1Salt and drought stress signal transduction in plants. Jian-Kang ZhuAnnu Rev Plant Biol200212221975No
70246512325.5119.1359.6Autophagy in the pathogenesis of disease. Beth Levine, Guido KroemerCell200818191218No
70323202320.045.5645.6Getting started with yeast. F ShermanMethods Enzymol19912005794Yes
70423182318.085.985.9Calmodulin plays a pivotal role in cellular regulation. W Y CheungScience19806243188No
70546292314.5100.1750.1MicroRNAs: small RNAs with a big role in gene regulation. Lin He, Gregory J HannonNat Rev Genet200415211354No
70623142314.00.00.0Application of a microtechnique to viral serological investigations. J L SeverJ Immunol196213910995Yes
70746282314.0211.34105.7The qualitative content analysis process. Satu Elo, Helvi KyngäsJ Adv Nurs200818352969Yes
70823142314.089.8589.8What is value in health care? Michael E PorterN Engl J Med201021142528Yes
70946262313.00.00.0Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. J Silness, H LoeActa Odontol Scand196414158464Yes
71023082308.051.3851.4Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. T HunterCell19957834742No
71123082308.054.1954.2Angiogenesis in life, disease and medicine. Peter CarmelietNature200516355210No
71223032303.00.00.0The Michigan alcoholism screening test: the quest for a new diagnostic instrument. M L SelzerAm J Psychiatry19715565851Yes
71323032303.053.853.8A decade of molecular biology of retinoic acid receptors. P ChambonFASEB J19968801176No
71446032301.5235.34117.7GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. Rod Peakall, Peter E SmouseBioinformatics201222820204Yes
71522962296.00.00.0Inositol phospholipids and cell surface receptor function. R H MichellBiochim Biophys Acta1975164246No
71622942294.00.00.0Separation of leukocytes from blood and bone marrow. Introduction. A BöyumScand J Clin Lab Invest Suppl19685707208Yes
71722912291.051.6951.7The structure and regulation of protein phosphatases. P CohenAnnu Rev Biochem19892549856No
71822912291.057.5757.6Bcl-2 and the regulation of programmed cell death. J C ReedJ Cell Biol19948294493No
71922902290.066.366.3Interleukin-1 and interleukin-1 antagonism. C A DinarelloBlood19911826616No
72045762288.0104.6252.3Death receptors: signaling and modulation. A Ashkenazi, V M DixitScience19989721089No
72122852285.050.3550.4Evolving concepts of rheumatoid arthritis. Gary S FiresteinNature200312748655No
72245612280.50.00.0High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. M N Berry, D S FriendJ Cell Biol19694900611Yes
72322782278.062.6962.7The magical number 4 in short-term memory: a reconsideration of mental storage capacity. N CowanBehav Brain Sci200111515286Yes
72422782278.00.00.0Muscle structure and theories of contraction. A F HuxleyProg Biophys Biophys Chem195713485191Yes
72545492274.5163.0481.5Complex network measures of brain connectivity: uses and interpretations. Mikail Rubinov, Olaf SpornsNeuroimage201019819337Yes
72668212273.7136.745.6Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Ron Edgar, Michael Domrachev, Alex E LashNucleic Acids Res200211752295Yes
72722692269.066.6566.7Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. P CorreaCancer Res19921458460No
72822692269.095.3395.3The Danish Civil Registration System. Carsten Bøcker PedersenScand J Public Health201121775345Yes
72922662266.045.7345.7SV40-transformed simian cells support the replication of early SV40 mutants. Y GluzmanCell19816260373Yes
73022632263.095.4695.5Qualitative research. Introducing focus groups. J KitzingerBMJ19957633241Yes
73122612261.056.2956.3Calcium signaling. David E ClaphamCell200718083096No
73222572257.076.4676.5Glutamate, nitric oxide and cell-cell signalling in the nervous system. J GarthwaiteTrends Neurosci19911708538No
73322532253.076.7476.7Accelerated Profile HMM Searches. Sean R EddyPLoS Comput Biol201122039361Yes
73422512251.056.0656.1MapChart: software for the graphical presentation of linkage maps and QTLs. R E VoorripsJ Hered200212011185Yes
73522492249.00.00.0Stereochemistry of cooperative effects in haemoglobin. M F PerutzNature19705528785Yes
73644952247.5140.7370.4Rapid isolation of high molecular weight plant DNA. M G Murray, W F ThompsonNucleic Acids Res19807433111Yes
73767422247.30.00.0On The Nature Of Allosteric Transitions: A Plausible Model. J Monod, J Wyman, J P ChangeuxJ Mol Biol196514343300Yes
73822452245.047.2447.2Tumour-educated macrophages promote tumour progression and metastasis. Jeffrey W PollardNat Rev Cancer200414708027No
73944882244.0103.0551.5A simple and very efficient method for generating cDNA libraries. U Gubler, B J HoffmanGene19836198242Yes
74044882244.091.1945.6The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Igor Vivanco, Charles L SawyersNat Rev Cancer200212094235No
74144872243.594.0647.0Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. D Bonnet, J E DickNat Med19979212098Yes
74222412241.00.00.0Evaluating the quality of medical care. A DonabedianMilbank Mem Fund Q19665338568No
74344782239.0117.6458.8Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Weizhong Li, Adam GodzikBioinformatics200616731699Yes
74444742237.091.9146.0Lipid rafts and signal transduction. K Simons, D ToomreNat Rev Mol Cell Biol200011413487No
74522362236.051.6651.7Mitochondrial diseases in man and mouse. D C WallaceScience199910066162No
74644622231.085.0842.5A novel genetic system to detect protein-protein interactions. S Fields, O SongNature19892547163Yes
74744582229.0123.461.7Management of hepatocellular carcinoma. Jordi Bruix, Morris ShermanHepatology200516250051No
74822232223.055.1455.1Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J Kyhse-AndersenJ Biochem Biophys Methods19846530509Yes
74922212221.056.0556.0A model for receptor-regulated calcium entry. J W PutneyCell Calcium19862420465No
75022202220.00.00.0Removal of fatty acids from serum albumin by charcoal treatment. R F ChenJ Biol Chem19676016603Yes
75122192219.00.00.0The information capacity of the human motor system in controlling the amplitude of movement. P M FittsJ Exp Psychol195413174710Yes
75222182218.071.2671.3Reactive oxygen species and the central nervous system. B HalliwellJ Neurochem19921402908No
75344362218.099.7549.9Organization and expression of eucaryotic split genes coding for proteins. R Breathnach, P ChambonAnnu Rev Biochem19816791577No
75422182218.053.453.4Mechanisms and genes of cellular suicide. H StellerScience19957878463No
75522162216.00.00.0Mechanisms of action of transmitters and other substances on smooth muscle. T B BoltonPhysiol Rev197937533No
75644322216.00.00.0The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J A Spudich, S WattJ Biol Chem19714254541Yes
75722132213.050.150.1Chemokines and leukocyte traffic. M BaggioliniNature19989560152No
75822112211.059.0159.0A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. P ChomczynskiBiotechniques19937692896Yes
75922102210.058.5458.5Causes and consequences of microRNA dysregulation in cancer. Carlo M CroceNat Rev Genet200919763153No
76022092209.049.349.3Molecular physiology of P2X receptors. R Alan NorthPhysiol Rev200212270951No
76122072207.085.3585.3Role of endothelium in responses of vascular smooth muscle. R F FurchgottCirc Res19836313250No
76266182206.0368.2122.7Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. P J Van Soest, J B Robertson, B A LewisJ Dairy Sci19911660498No
76322062206.053.4753.5Protein kinase C and lipid signaling for sustained cellular responses. Y NishizukaFASEB J19957737456No
76444122206.0120.760.4Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Marie-Christine Daniel, Didier AstrucChem Rev200414719978No
76522052205.061.7861.8Molecular diversity of glutamate receptors and implications for brain function. S NakanishiScience19921329206No
76622052205.070.370.3SF-36 health survey update. J E WareSpine (Phila Pa 1976)200011124729No
76722032203.072.6272.6adegenet: a R package for the multivariate analysis of genetic markers. Thibaut JombartBioinformatics200818397895Yes
76822012201.066.0366.0Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. M LeavittMedGenMed200111549951No
76943982199.00.00.0The interpretation of protein structures: estimation of static accessibility. B Lee, F M RichardsJ Mol Biol19715551392Yes
77021992199.078.6278.6Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. B N AmesScience19836351251No
77121972197.00.00.0[Rapid physiological coagulation method in determination of fibrinogen]. A ClaussActa Haematol195713434757Yes
77243922196.00.00.0On the size of the active site in proteases. I. Papain. I Schechter, A BergerBiochem Biophys Res Commun19676035483Yes
77343792189.5115.5657.8A receptor-mediated pathway for cholesterol homeostasis. M S Brown, J L GoldsteinScience19863513311No
77421882188.056.5356.5Molecular basis of bacterial outer membrane permeability revisited. Hiroshi NikaidoMicrobiol Mol Biol Rev200314665678No
77543692184.5220.76110.4Stress, social support, and the buffering hypothesis. S Cohen, T A WillsPsychol Bull19853901065No
77643682184.00.00.0A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. J E TILL, E A McCULLOCHRadiat Res196113776896Yes
77721842184.0119.85119.8Interrater reliability: the kappa statistic. Mary L McHughBiochem Med (Zagreb)201223092060Yes
77843662183.00.00.0Periodontal Disease In Pregnancy. I. Prevalence And Severity. H Loe, J SilnessActa Odontol Scand196314121956Yes
77921832183.079.6279.6A computational approach to edge detection. J CannyIEEE Trans Pattern Anal Mach Intell198621869365Yes
78021822182.068.2368.2Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. R A DeFronzoDiabetes19883289989No
78121812181.068.1168.1Prooxidant states and tumor promotion. P A CeruttiScience19852981433No
78243532176.595.6947.8New functions for the matrix metalloproteinases in cancer progression. Mikala Egeblad, Zena WerbNat Rev Cancer200211990853No
78321762176.00.00.0A new specific color reaction of hexuronic acids. Z DischeJ Biol Chem194720281638Yes
78443442172.0148.4974.2Random-effects models for longitudinal data. N M Laird, J H WareBiometrics19827168798Yes
78543442172.0141.5670.8Accurate and simple analytic representation of the electron-gas correlation energy. Perdew, WangPhys Rev B Condens Matter199210001404Yes
78621712171.065.4765.5Two-sided confidence intervals for the single proportion: comparison of seven methods. R G NewcombeStat Med19989595616Yes
78721712171.053.9353.9Ischemic cell death in brain neurons. P LiptonPhysiol Rev199910508238No
78843312165.5446.97223.5A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. Terry K Koo, Mae Y LiJ Chiropr Med201627330520Yes
78943222161.0128.8864.4Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. C J Murray, A D LopezLancet19979167458Yes
79021582158.058.2258.2Dietary pattern analysis: a new direction in nutritional epidemiology. Frank B HuCurr Opin Lipidol200211790957No
79121572157.048.4148.4The regulation of AP-1 activity by mitogen-activated protein kinases. M KarinJ Biol Chem19957622446No
79221572157.00.00.0A Rationale And Test For The Number Of Factors In Factor Analysis. J L HornPsychometrika196514306381Yes
79321552155.00.00.0Sedimentation Studies Of The Size And Shape Of Dna. F W StudierJ Mol Biol196514290352Yes
794129222153.7319.1953.2Phaser crystallographic software. Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J ReadJ Appl Crystallogr200719461840Yes
79521532153.049.2849.3Chemokines. B J RollinsBlood19979242519No
79621522152.00.00.0The plasma lecithins:cholesterol acyltransferase reaction. J A GlomsetJ Lipid Res19684868699No
79721512151.079.8479.8Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. H W SteinbuschNeuroscience19817017455Yes
79821502150.066.2966.3Diagnosis of Alzheimer's disease. Z S KhachaturianArch Neurol19852864910Yes
79942992149.5127.6463.8Pattern recognition receptors and inflammation. Osamu Takeuchi, Shizuo AkiraCell201020303872No
80021492149.042.0242.0Java Treeview--extensible visualization of microarray data. Alok J SaldanhaBioinformatics200415180930Yes
80164452148.3209.1969.7Arlequin (version 3.0): an integrated software package for population genetics data analysis. Laurent Excoffier, Guillaume Laval, Stefan SchneiderEvol Bioinform Online200719325852Yes
80242932146.5168.1684.1FLASH: fast length adjustment of short reads to improve genome assemblies. Tanja Magoč, Steven L SalzbergBioinformatics201121903629Yes
80321442144.00.00.0The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. W W ClelandBiochim Biophys Acta196314021667Yes
80442862143.096.0748.0Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. F Sallusto, A LanzavecchiaJ Exp Med19948145033Yes
80542852142.5131.1765.6Neural mechanisms of selective visual attention. R Desimone, J DuncanAnnu Rev Neurosci19957605061No
80642822141.00.00.0The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. H P Misra, I FridovichJ Biol Chem19724623845Yes
80742822141.099.7449.9The Bcl-2 protein family: arbiters of cell survival. J M Adams, S CoryScience19989735050No
80864212140.3150.8550.3The biology of VEGF and its receptors. Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouterNat Med200312778165No
80942712135.5117.1558.6Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. C W Elston, I O EllisHistopathology19911757079Yes
81021352135.086.0186.0Effective physician-patient communication and health outcomes: a review. M A StewartCMAJ19957728691Yes
81121342134.0125.08125.1Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Daniël LakensFront Psychol201324324449No
81285332133.2279.3469.8Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Qiong Wang, George M Garrity, James M Tiedje, James R ColeAppl Environ Microbiol200717586664Yes
81321302130.041.2741.3Histone acetylation in chromatin structure and transcription. M GrunsteinNature19979311776No
81442512125.5195.0597.5Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. N S Jacobson, P TruaxJ Consult Clin Psychol19912002127Yes
81542512125.50.00.0A Simplified Lead Citrate Stain For Use In Electron Microscopy. J H Venable, R CoggeshallJ Cell Biol196514287192Yes
81621242124.041.3541.4Targeting RAS signalling pathways in cancer therapy. Julian DownwardNat Rev Cancer200312509763No
81721232123.063.9263.9Scaffolds in tissue engineering bone and cartilage. D W HutmacherBiomaterials200011071603Yes
81821222122.00.00.0Intracellular aspects of the process of protein synthesis. G PaladeScience19751096303No
81921222122.046.346.3Telomere measurement by quantitative PCR. Richard M CawthonNucleic Acids Res200212000852Yes
82021212121.041.9542.0Protein modules and signalling networks. T PawsonNature19957531822No
82121212121.049.6849.7A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Douglas C WallaceAnnu Rev Genet200516285865No
82263612120.3189.8863.3Bacterial biofilms: a common cause of persistent infections. J W Costerton, P S Stewart, E P GreenbergScience199910334980No
82363612120.3372.46124.2Deep learning. Yann LeCun, Yoshua Bengio, Geoffrey HintonNature201526017442No
82421132113.00.00.0Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. D AminoffBiochem J196113860975Yes
82563322110.7289.3496.4Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. J L Cox, J M Holden, R SagovskyBr J Psychiatry19873651732Yes
82621092109.080.1180.1Specific impairments of planning. T ShallicePhilos Trans R Soc Lond B Biol Sci19826125971Yes
82742142107.0102.3951.2Signal integration in the endoplasmic reticulum unfolded protein response. David Ron, Peter WalterNat Rev Mol Cell Biol200717565364No
82842122106.0107.1953.6Function and activation of NF-kappa B in the immune system. P A Baeuerle, T HenkelAnnu Rev Immunol19948011280No
82921052105.053.3353.3Modularity and community structure in networks. M E J NewmanProc Natl Acad Sci U S A200616723398Yes
83042092104.5105.552.8Regulation of the mevalonate pathway. J L Goldstein, M S BrownNature19901967820No
83121042104.064.164.1Physiology and neurobiology of stress and adaptation: central role of the brain. Bruce S McEwenPhysiol Rev200717615391No
83242062103.00.00.0Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. R B Devereux, N ReichekCirculation1977138494Yes
83342062103.0149.8774.9The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. S H Downs, N BlackJ Epidemiol Community Health19989764259Yes
83442052102.594.6547.3Mass spectrometry-based proteomics. Ruedi Aebersold, Matthias MannNature200312634793No
83521022102.050.1250.1Patterns of amino acids near signal-sequence cleavage sites. G von HeijneEur J Biochem19836852022Yes
83621022102.064.764.7A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. Heng LiBioinformatics201121903627Yes
83721002100.088.4988.5A systematic method for clinical description and classification of personality variants. A proposal. C R CloningerArch Gen Psychiatry19873579504Yes
83883982099.5246.1561.5GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. Berk Hess, Carsten Kutzner, David van der Spoel, Erik LindahlJ Chem Theory Comput200826620784Yes
83920982098.050.2950.3Specification of cerebral cortical areas. P RakicScience19883291116No
84041952097.5100.3350.2Assembly of asparagine-linked oligosaccharides. R Kornfeld, S KornfeldAnnu Rev Biochem19853896128No
84120942094.00.00.0The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. D E AtkinsonBiochemistry19684972613Yes
84241872093.585.9543.0Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Yigong Shi, Joan MassaguéCell200312809600No
84341832091.50.00.0Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. T V Bliss, T LomoJ Physiol19734727084Yes
84420912091.047.1247.1NOX enzymes and the biology of reactive oxygen. J David LambethNat Rev Immunol200415039755No
84520892089.043.3343.3The molecular biology of memory storage: a dialogue between genes and synapses. E R KandelScience200111691980No
84641762088.0122.6161.3Distributed hierarchical processing in the primate cerebral cortex. D J Felleman, D C Van EssenCereb Cortex19911822724No
84741762088.0154.2477.1The attention system of the human brain. M I Posner, S E PetersenAnnu Rev Neurosci19902183676No
84820872087.049.3549.4Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. G TrinchieriAnnu Rev Immunol19957612223No
84941672083.5120.8960.4Angiogenic factors. J Folkman, M KlagsbrunScience19872432664No
85041672083.5214.47107.2phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. Paul J McMurdie, Susan HolmesPLoS One201323630581Yes
85120822082.044.6844.7Mammalian G1 cyclins. C J SherrCell19938513492No
85262362078.70.00.0Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. B N Ames, J Mccann, E YamasakiMutat Res1975768755Yes
853166242078.0541.9267.7The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C SiebertN Engl J Med19938366922Yes
85420762076.00.00.0Method For Assay Of Intestinal Disaccharidases. A DahlqvistAnal Biochem196414106916Yes
85541512075.5107.4753.7Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. E Lander, L KruglyakNat Genet19957581446Yes
85641512075.5123.0861.5Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. J S Beckman, W H KoppenolAm J Physiol19968944624No
85720712071.00.00.0Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. F F JöbsisScience1977929199Yes
85820702070.046.1946.2Cisplatin: mode of cytotoxic action and molecular basis of resistance. Zahid H SiddikOncogene200314576837No
85920702070.057.9958.0Immunological and inflammatory functions of the interleukin-1 family. Charles A DinarelloAnnu Rev Immunol200919302047No
86061982066.0145.6348.5MOLMOL: a program for display and analysis of macromolecular structures. R Koradi, M Billeter, K WüthrichJ Mol Graph19968744573Yes
86120662066.053.9654.0A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Pascal FriesTrends Cogn Sci200516150631No
86220632063.063.363.3The unbiased estimation of number and sizes of arbitrary particles using the disector. D C SterioJ Microsc19846737468Yes
86320632063.00.00.0Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. J C SkouPhysiol Rev196514337569No
86441252062.5158.3179.2Self-rated health and mortality: a review of twenty-seven community studies. E L Idler, Y BenyaminiJ Health Soc Behav19979097506No
86541252062.5108.6154.3Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Klaus Apel, Heribert HirtAnnu Rev Plant Biol200415377225No
86620622062.00.00.0Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. J W LittlefieldScience196414168277Yes
86720572057.051.351.3The anatomy and taxonomy of protein structure. J S RichardsonAdv Protein Chem19817020376No
86820562056.053.7553.8Breast cancer and hormone-replacement therapy in the Million Women Study. Valerie BeralLancet200312927427Yes
86941092054.587.5743.8A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. G Shaw, R KamenCell19863488815Yes
87061592053.0181.4760.5Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. C E Murry, R B Jennings, K A ReimerCirculation19863769170Yes
87141012050.50.00.0Plaque formation and isolation of pure lines with poliomyelitis viruses. R Dulbecco, M VogtJ Exp Med195413130792Yes
87241012050.5104.252.1Protein misfolding, functional amyloid, and human disease. Fabrizio Chiti, Christopher M DobsonAnnu Rev Biochem200616756495No
87320502050.00.00.0Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. T HiguchiJ Pharm Sci196314088963Yes
87461362045.3172.1157.4RNA-Seq: a revolutionary tool for transcriptomics. Zhong Wang, Mark Gerstein, Michael SnyderNat Rev Genet200919015660No
87540902045.0128.7864.4Missing data: our view of the state of the art. Joseph L Schafer, John W GrahamPsychol Methods200212090408Yes
87620452045.00.00.0Isolation by Distance. S WrightGenetics194317247074Yes
87740872043.598.5249.3AKT/PKB signaling: navigating downstream. Brendan D Manning, Lewis C CantleyCell200717604717No
87861192039.70.00.0Immunochemical quantitation of antigens by single radial immunodiffusion. G Mancini, A O Carbonara, J F HeremansImmunochemistry19654956917Yes
87940772038.5107.7853.9Acute-phase proteins and other systemic responses to inflammation. C Gabay, I KushnerN Engl J Med19999971870No
88020362036.077.0577.0DNA methylation age of human tissues and cell types. Steve HorvathGenome Biol201324138928Yes
88120352035.042.7342.7G1 events and regulation of cell proliferation. A B PardeeScience19892683075No
88220352035.064.1164.1Parkinson's disease: clinical features and diagnosis. J JankovicJ Neurol Neurosurg Psychiatry200818344392No
88320332033.067.9868.0Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Peter C AustinStat Med200919757444Yes
88420312031.052.352.3RGD and other recognition sequences for integrins. E RuoslahtiAnnu Rev Cell Dev Biol19968970741No
88520292029.069.2469.2A classification of glycosyl hydrolases based on amino acid sequence similarities. B HenrissatBiochem J19911747104Yes
88640562028.0100.1750.1Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. P Liang, A B PardeeScience19921354393Yes
88720272027.00.00.0Antigen-antibody reactions in gels. O OuchterlonyActa Pathol Microbiol Scand194918143039Yes
88860782026.00.00.0Glucose clamp technique: a method for quantifying insulin secretion and resistance. R A DeFronzo, J D Tobin, R AndresAm J Physiol1979382871Yes
88940502025.0105.7852.9A global optimisation method for robust affine registration of brain images. M Jenkinson, S SmithMed Image Anal200111516708Yes
89020222022.00.00.0Analysis of bacteriophage T7 early RNAs and proteins on slab gels. F W StudierJ Mol Biol19734760132Yes
89120212021.069.9670.0Ethical authorship and publishing. Andrew J S CoatsInt J Cardiol200919046787No
89220202020.059.3659.4ATP-regulated K+ channels in cardiac muscle. A NomaNature19836310409Yes
89320202020.082.9382.9A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. E L BradleyArch Surg19938489394No
89440402020.0134.2767.1Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. R M Ryan, E L DeciAm Psychol200011392867Yes
89520182018.060.9360.9Stress, adaptation, and disease. Allostasis and allostatic load. B S McEwenAnn N Y Acad Sci19989629234No
89620162016.048.0948.1Interleukin-2: inception, impact, and implications. K A SmithScience19883131876No
89760472015.7179.459.8Quantum mechanical continuum solvation models. Jacopo Tomasi, Benedetta Mennucci, Roberto CammiChem Rev200516092826Yes
89840272013.581.1240.6The fundamental role of epigenetic events in cancer. Peter A Jones, Stephen B BaylinNat Rev Genet200212042769No
89920132013.068.268.2Working memory. A BaddeleyScience19921736359No
90020132013.059.7859.8Formation and Structure of Self-Assembled Monolayers. Abraham UlmanChem Rev199611848802Yes
90140232011.5110.1155.1The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Karen Bedard, Karl-Heinz KrausePhysiol Rev200717237347No
90220112011.057.2357.2Superoxide radical and superoxide dismutases. I FridovichAnnu Rev Biochem19957574505No
90320112011.045.545.5Nitric oxide and the immune response. C BogdanNat Immunol200111577346No
90420092009.067.2667.3Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. W A CraigClin Infect Dis19989455502No
90520072007.043.143.1Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Shimon SakaguchiNat Immunol200515785760No
90620072007.094.994.9Structural Model Evaluation and Modification: An Interval Estimation Approach. J H SteigerMultivariate Behav Res199026794479Yes
90720032003.044.5644.6Structural design and molecular evolution of a cytokine receptor superfamily. J F BazanProc Natl Acad Sci U S A19902169613Yes
90819991999.00.00.0Presidential Address-1976. Social support as a moderator of life stress. S CobbPsychosom Med1976981490Yes
90939911995.5127.6263.8SPSS and SAS procedures for estimating indirect effects in simple mediation models. Kristopher J Preacher, Andrew F HayesBehav Res Methods Instrum Comput200415641418Yes
91019951995.047.7947.8Calcium signaling. D E ClaphamCell19957834745No
91119951995.045.3145.3Complement. First of two parts. M J WalportN Engl J Med200111287977No
91219941994.042.8942.9XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. D E McReeJ Struct Biol199910222271Yes
91359801993.3165.3655.1ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Kai Wang, Mingyao Li, Hakon HakonarsonNucleic Acids Res201020601685Yes
91419921992.00.00.0Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. P MitchellBiol Rev Camb Philos Soc19665329743No
91519911991.00.00.0The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. U E LoeningBiochem J19675339944Yes
91639811990.580.3340.2Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. M Gossen, H BujardProc Natl Acad Sci U S A19921319065Yes
91719891989.083.2983.3Role of Streptococcus mutans in human dental decay. W J LoescheMicrobiol Rev19863540569No
91819891989.067.0367.0Biodiesel from microalgae. Yusuf ChistiBiotechnol Adv200717350212No
91939751987.5109.1254.6New perspectives in cell adhesion: RGD and integrins. E Ruoslahti, M D PierschbacherScience19872821619No
92039751987.5105.1952.6Myeloid-derived suppressor cells as regulators of the immune system. Dmitry I Gabrilovich, Srinivas NagarajNat Rev Immunol200919197294No
92119871987.053.6853.7The molecular pathology of Alzheimer's disease. D J SelkoeNeuron19911673054No
92239741987.00.00.0Loss of recent memory after bilateral hippocampal lesions. W B Scoville, B MilnerJ Neurol Neurosurg Psychiatry195713406589Yes
92319841984.048.3848.4The inflammatory reflex. Kevin J TraceyNature200212490958No
92419821982.052.8452.8The heme oxygenase system: a regulator of second messenger gases. M D MainesAnnu Rev Pharmacol Toxicol19979131263No
92519791979.062.6262.6Hybrid porous solids: past, present, future. Gérard FéreyChem Soc Rev200818197340Yes
92619791979.062.262.2Efficient methods to compute genomic predictions. P M VanRadenJ Dairy Sci200818946147Yes
92739571978.5112.6656.3A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Y Matsumura, H MaedaCancer Res19862946403Yes
92839481974.0104.4852.2The heat-shock proteins. S Lindquist, E A CraigAnnu Rev Genet19882853609No
92939341967.0116.8258.4Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Michael D Fox, Marcus E RaichleNat Rev Neurosci200717704812No
93019661966.043.4143.4The mitogen-activated protein kinase signal transduction pathway. R J DavisJ Biol Chem19938325833No
93119651965.065.5165.5Eye movements in reading and information processing: 20 years of research. K RaynerPsychol Bull19989849112No
93239291964.50.00.0Genetic regulatory mechanisms in the synthesis of proteins. F Jacob, J MonodJ Mol Biol196113718526Yes
93319641964.057.8657.9Protein oxidation and aging. E R StadtmanScience19921355616No
93419631963.055.4555.5The importance of selenium to human health. M P RaymanLancet200010963212No
93519621962.053.7253.7Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. J FolkmanN Engl J Med19957491141No
93639241962.00.00.0Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. W R Morrison, L M SmithJ Lipid Res196414221106Yes
93719621962.00.00.0Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. G BertaniJ Bacteriol195114888646Yes
93819611961.090.4890.5Central sensitization: implications for the diagnosis and treatment of pain. Clifford J WoolfPain201120961685No
93939201960.0100.7450.4Nonparametric permutation tests for functional neuroimaging: a primer with examples. Thomas E Nichols, Andrew P HolmesHum Brain Mapp200211747097Yes
94019601960.039.5839.6Shelterin: the protein complex that shapes and safeguards human telomeres. Titia de LangeGenes Dev200516166375No
94119591959.058.658.6Pancreatic cancer. Manuel HidalgoN Engl J Med201020427809No
94258721957.3121.7940.6Rapid and efficient site-specific mutagenesis without phenotypic selection. T A Kunkel, J D Roberts, R A ZakourMethods Enzymol19873323813Yes
94319571957.00.00.0Purinergic nerves. G BurnstockPharmacol Rev19724404211No
94419561956.061.5761.6Fetal origins of coronary heart disease. D J BarkerBMJ19957613432No
94519541954.00.00.0The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. S V BoydenJ Exp Med195114803635Yes
94619521952.039.3739.4NK cell recognition. Lewis L LanierAnnu Rev Immunol200515771571No
94739021951.00.00.0A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. R F Beers, I W SizerJ Biol Chem195214938361Yes
94819501950.052.8452.8Descending control of pain. Mark J MillanProg Neurobiol200212034378No
94919491949.066.866.8Human error: models and management. J ReasonBMJ200010720363Yes
95019491949.048.1448.1Rab GTPases as coordinators of vesicle traffic. Harald StenmarkNat Rev Mol Cell Biol200919603039No
95119451945.069.9269.9Determination of glutathione and glutathione disulfide in biological samples. M E AndersonMethods Enzymol19854088074Yes
95219441944.054.5354.5The biology of interleukin-6. T KishimotoBlood19892473791No
95319421942.00.00.0Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. A FleckensteinAnnu Rev Pharmacol Toxicol1977326161No
95419421942.00.00.0Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. J P ChamberlainAnal Biochem1979543547Yes
95538841942.096.0948.0Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. G G Glenner, C W WongBiochem Biophys Res Commun19846375662Yes
95619411941.040.5240.5Mechanisms of intracellular protein transport. J E RothmanNature19947969419No
95719411941.00.00.0The oxidation of ribonuclease with performic acid. C H HirsJ Biol Chem195613319283Yes
95819381938.052.9953.0Working memory: looking back and looking forward. Alan BaddeleyNat Rev Neurosci200314523382No
95919371937.074.7374.7Epidemiology of viral hepatitis and hepatocellular carcinoma. Hashem B El-SeragGastroenterology201222537432No
96038721936.00.00.0Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. I W McLean, P K NakaneJ Histochem Cytochem19744374474Yes
96138711935.580.6340.3Mammalian MAP kinase signalling cascades. L Chang, M KarinNature200111242034No
962116051934.2266.3144.4NMRPipe: a multidimensional spectral processing system based on UNIX pipes. F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A BaxJ Biomol NMR19958520220Yes
96319341934.046.8146.8Pathways towards and away from Alzheimer's disease. Mark P MattsonNature200415295589No
96419331933.056.3756.4Estimating causal effects from large data sets using propensity scores. D B RubinAnn Intern Med19979382394No
96538661933.0119.0359.5The number of people with glaucoma worldwide in 2010 and 2020. H A Quigley, A T BromanBr J Ophthalmol200616488940Yes
96638621931.0126.2463.1A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Gary J Bennett, Y-K XiePain19882837713Yes
96757911930.3116.6438.9Control of regulatory T cell development by the transcription factor Foxp3. Shohei Hori, Takashi Nomura, Shimon SakaguchiScience200312522256Yes
96819301930.057.8457.8Intracellular calcium homeostasis. E CarafoliAnnu Rev Biochem19873304139No
96919301930.060.3660.4A two process model of sleep regulation. A A BorbélyHum Neurobiol19827185792Yes
97019301930.050.5450.5Inferring the historical patterns of biological evolution. M PagelNature199910553904Yes
97119281928.063.9564.0Spinal and supraspinal factors in human muscle fatigue. S C GandeviaPhysiol Rev200111581501No
97219281928.049.6349.6Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Edward V LoftusGastroenterology200415168363Yes
97338561928.0101.3150.7Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Hashem B El-Serag, K Lenhard RudolphGastroenterology200717570226No
97438541927.00.00.0Judgment under Uncertainty: Heuristics and Biases. A Tversky, D KahnemanScience197417835457Yes
97519261926.050.4350.4Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. Jane GlazebrookAnnu Rev Phytopathol200516078883No
97638511925.592.4946.2Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. B A Reynolds, S WeissScience19921553558Yes
97738511925.5108.4554.2Insulin-like growth factors and their binding proteins: biological actions. J I Jones, D R ClemmonsEndocr Rev19957758431No
97838491924.5106.8753.4Alzheimer's disease: the amyloid cascade hypothesis. J A Hardy, G A HigginsScience19921566067No
97938491924.584.9742.5Lessons from hereditary colorectal cancer. K W Kinzler, B VogelsteinCell19968861899No
98019231923.035.4735.5ATM and related protein kinases: safeguarding genome integrity. Yosef ShilohNat Rev Cancer200312612651No
98119231923.00.00.0Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. M KunitzJ Gen Physiol194719873496Yes
98257681922.7155.3251.8Cortical surface-based analysis. I. Segmentation and surface reconstruction. A M Dale, B Fischl, M I SerenoNeuroimage19999931268Yes
98319221922.064.9565.0Plant products as antimicrobial agents. M M CowanClin Microbiol Rev199910515903No
98419221922.041.4741.5Role of angiogenesis in tumor growth and metastasis. Judah FolkmanSemin Oncol200212516034No
98538401920.00.00.0Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. A C Chang, S N CohenJ Bacteriol1978149110Yes
98638391919.584.4342.2The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. A J Ridley, A HallCell19921643657Yes
98719191919.035.5235.5In situ hybridization: an improved whole-mount method for Xenopus embryos. R M HarlandMethods Cell Biol19911811161Yes
98838381919.00.00.0Acetylornithinase of Escherichia coli: partial purification and some properties. H J Vogel, D M BonnerJ Biol Chem195613278318Yes
98938381919.0107.9654.0UniFrac: a new phylogenetic method for comparing microbial communities. Catherine Lozupone, Rob KnightAppl Environ Microbiol200516332807Yes
99019181918.040.7440.7A cell culture model for T lymphocyte clonal anergy. R H SchwartzScience19902113314Yes
991115081918.0410.268.4Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell ParkinInt J Cancer201021351269Yes
99219161916.039.5239.5CpG motifs in bacterial DNA and their immune effects. Arthur M KriegAnnu Rev Immunol200211861616No
99338311915.5179.2489.6Stages and processes of self-change of smoking: toward an integrative model of change. J O Prochaska, C C DiClementeJ Consult Clin Psychol19836863699Yes
99419131913.071.3371.3International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. C HerrmannJ Psychosom Res19979055211No
99538241912.0102.1451.1Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. M Matsuda, R A DeFronzoDiabetes Care199910480510Yes
99619111911.081.4981.5The validity and practicality of sun-reactive skin types I through VI. T B FitzpatrickArch Dermatol19883377516Yes
99719101910.047.1747.2DNA topoisomerases. J C WangAnnu Rev Biochem19852992360No
99819091909.064.864.8Intermediate filaments as mechanical integrators of cellular space. E LazaridesNature19807188712Yes
99919091909.00.00.0Influences of glucose loading and of injected insulin on hepatic glucose output. R SteeleAnn N Y Acad Sci195913833973Yes
100057201906.7173.0157.7Immunity, inflammation, and cancer. Sergei I Grivennikov, Florian R Greten, Michael KarinCell201020303878No
100119051905.065.8265.8The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Claudio HetzNat Rev Mol Cell Biol201222251901No
100219041904.051.1151.1DNA topoisomerase poisons as antitumor drugs. L F LiuAnnu Rev Biochem19892549853No
100357121904.0224.4674.8Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. G Muyzer, E C de Waal, A G UitterlindenAppl Environ Microbiol19937683183Yes
100419031903.081.1881.2A rating scale for drug-induced akathisia. T R BarnesBr J Psychiatry19892574607Yes
100519021902.085.5285.5The Children's Depression, Inventory (CDI). M KovacsPsychopharmacol Bull19854089116Yes
100619021902.057.3157.3Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Claudiu T SupuranNat Rev Drug Discov200818167490No
100719011901.053.2853.3T cell exhaustion. E John WherryNat Immunol201121739672No
100838011900.5103.3151.7Inositol phosphates and cell signalling. M J Berridge, R F IrvineNature19892550825No
100919001900.00.00.0Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. D M NevilleJ Biol Chem19715127429Yes
101076001900.0174.543.6Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. A Krogh, B Larsson, G von Heijne, E L SonnhammerJ Mol Biol200111152613Yes
101118981898.00.00.0On estimating the relation between blood group and disease. B WoolfAnn Hum Genet195514388528Yes
101256931897.7193.1764.4Parallel organization of functionally segregated circuits linking basal ganglia and cortex. G E Alexander, M R DeLong, P L StrickAnnu Rev Neurosci19863085570No
101318971897.00.00.0Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. A BreslowAnn Surg19705477666Yes
101418971897.00.00.0Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? J V NeelAm J Hum Genet196213937884Yes
101518961896.082.782.7Missing data analysis: making it work in the real world. John W GrahamAnnu Rev Psychol200918652544No
101637911895.50.00.0Variations in pattern of pubertal changes in girls. W A Marshall, J M TannerArch Dis Child19695785179Yes
101718951895.00.00.0In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. T R ChenExp Cell Res197765285Yes
101818951895.084.3384.3Brain dopamine receptors. P SeemanPharmacol Rev19806117090No
101956841894.71753.55584.5Cancer statistics, 2020. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin202031912902Yes
102018931893.066.1666.2Simplified calculation of body-surface area. R D MostellerN Engl J Med19873657876Yes
102137861893.096.1848.1Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. P J Barnes, M KarinN Engl J Med19979091804No
102237811890.578.5839.3Network biology: understanding the cell's functional organization. Albert-László Barabási, Zoltán N OltvaiNat Rev Genet200414735121No
102318901890.065.3165.3Qualitative research: standards, challenges, and guidelines. K MalterudLancet200111513933Yes
102418901890.00.00.0Analysis of tissue and arterial blood temperatures in the resting human forearm. H H PennesJ Appl Physiol194818887578Yes
102518901890.057.1157.1The nuclear factor NF-kappaB pathway in inflammation. Toby LawrenceCold Spring Harb Perspect Biol200920457564No
102618891889.042.9743.0Signal sequences. The limits of variation. G von HeijneJ Mol Biol19854032478Yes
102737741887.090.2845.1Base-calling of automated sequencer traces using phred. II. Error probabilities. B Ewing, P GreenGenome Res19989521922Yes
102818851885.00.00.0Complete nucleotide sequence of the Escherichia coli plasmid pBR322. J G SutcliffeCold Spring Harb Symp Quant Biol1979383387Yes
102918851885.057.0257.0Calbindin D-28k and parvalbumin in the rat nervous system. M R CelioNeuroscience19902199841Yes
103018851885.039.3139.3Mechanisms of type-I- and type-II-interferon-mediated signalling. Leonidas C PlataniasNat Rev Immunol200515864272No
103118831883.00.00.0A modified card sorting test sensitive to frontal lobe defects. H E NelsonCortex19761009768Yes
103218831883.054.9555.0Excitotoxic cell death. D W ChoiJ Neurobiol19921361523No
103356481882.70.00.0Research diagnostic criteria: rationale and reliability. R L Spitzer, J Endicott, E RobinsArch Gen Psychiatry1978655775Yes
103437641882.093.446.7Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. M Nei, T GojoboriMol Biol Evol19863444411Yes
103518811881.040.2340.2Molecular bases for circadian clocks. J C DunlapCell19999988221No
103637601880.00.00.0An efficient mRNA-dependent translation system from reticulocyte lysates. H R Pelham, R J JacksonEur J Biochem1976823012Yes
103737571878.5108.9254.5Application of phylogenetic networks in evolutionary studies. Daniel H Huson, David BryantMol Biol Evol200616221896Yes
103818771877.042.1542.1Biology of natural killer cells. G TrinchieriAdv Immunol19892683611No
103918771877.034.934.9Signaling--2000 and beyond. T HunterCell200010647936No
104018731873.053.1753.2The episodic buffer: a new component of working memory? BaddeleyTrends Cogn Sci200011058819Yes
104118721872.039.9940.0Metastasis to bone: causes, consequences and therapeutic opportunities. Gregory R MundyNat Rev Cancer200212154351No
104256111870.3141.7147.2GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. R A Jefferson, T A Kavanagh, M W BevanEMBO J19873327686Yes
104374791869.8188.1647.0p53 mutations in human cancers. M Hollstein, D Sidransky, B Vogelstein, C C HarrisScience19911905840No
104418671867.074.8974.9Approximate entropy as a measure of system complexity. S M PincusProc Natl Acad Sci U S A199111607165Yes
104518671867.053.8553.9The blood-brain barrier in health and chronic neurodegenerative disorders. Berislav V ZlokovicNeuron200818215617No
104618661866.043.343.3Defensins: antimicrobial peptides of innate immunity. Tomas GanzNat Rev Immunol200312949495No
104737311865.587.1543.6The Fas death factor. S Nagata, P GolsteinScience19957533326No
104837281864.096.5948.3Leptin and the regulation of body weight in mammals. J M Friedman, J L HalaasNature19989796811No
104918641864.055.0655.1Japanese Classification of Gastric Carcinoma - 2nd English Edition - Japanese Gastric Cancer AssociationGastric Cancer199811957040Yes
105018631863.048.7448.7Flow-mediated endothelial mechanotransduction. P F DaviesPhysiol Rev19957624393No
105137141857.00.00.0Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. J G Rheinwald, H GreenCell19751052771Yes
105237141857.081.1840.6Raster3D: photorealistic molecular graphics. E A Merritt, D J BaconMethods Enzymol199718488322Yes
105337101855.0122.3761.2Oxygen toxicity, oxygen radicals, transition metals and disease. B Halliwell, J M GutteridgeBiochem J19846326753No
105418531853.00.00.0Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. S CohenJ Biol Chem196213880319Yes
105518511851.039.1939.2The expanding role of mitochondria in apoptosis. X WangGenes Dev200111711427No
105618501850.062.6962.7The use of a plus-maze to measure anxiety in the mouse. R G ListerPsychopharmacology (Berl)19873110839Yes
105736981849.076.9138.5Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Rudolf Jaenisch, Adrian BirdNat Genet200312610534No
105818471847.051.6651.7Epidemiology of insomnia: what we know and what we still need to learn. Maurice M OhayonSleep Med Rev200212531146Yes
105918441844.043.4943.5A clearer vision for in vivo imaging. R WeisslederNat Biotechnol200111283581No
106036881844.00.00.0Immunoassay of insulin with insulin-antibody precipitate. C N Hales, P J RandleBiochem J196313952078Yes
106155311843.70.00.0A rapid method for the isolation of functional thymus-derived murine lymphocytes. M H Julius, E Simpson, L A HerzenbergEur J Immunol19734587740Yes
106218431843.045.3945.4Thioredoxin. A HolmgrenAnnu Rev Biochem19853896121No
106336851842.5107.7153.9Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. B J Marshall, J R WarrenLancet19846145023Yes
106436831841.584.7842.4Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. T Miyashita, J C ReedCell19957834749Yes
106536831841.5152.9176.5Extracellular vesicles: exosomes, microvesicles, and friends. Graça Raposo, Willem StoorvogelJ Cell Biol201323420871No
106636801840.076.3738.2The Wnt signaling pathway in development and disease. Catriona Y Logan, Roel NusseAnnu Rev Cell Dev Biol200415473860No
106773531838.2193.2848.3Matrix elasticity directs stem cell lineage specification. Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E DischerCell200616923388Yes
106818361836.033.733.7The regulation of E2F by pRB-family proteins. N DysonGenes Dev19989694791No
106918361836.045.2945.3Animal mitochondrial genomes. J L BooreNucleic Acids Res199910101183No
107036671833.576.1538.1Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Rik Derynck, Ying E ZhangNature200314534577No
107136631831.588.1244.1Brown adipose tissue: function and physiological significance. Barbara Cannon, Jan NedergaardPhysiol Rev200414715917No
107236621831.094.1947.1Cutaneous wound healing. A J Singer, R A ClarkN Engl J Med199910471461No
107336611830.588.4344.2The acute respiratory distress syndrome. L B Ware, M A MatthayN Engl J Med200010793167No
107418301830.00.00.0A rating instrument for anxiety disorders. W W ZungPsychosomatics19715172928Yes
107536591829.589.9945.0The future of genetic studies of complex human diseases. N Risch, K MerikangasScience19968801636Yes
107673141828.5256.3964.1Reporting results of cancer treatment. A B Miller, B Hoogstraten, M Staquet, A WinklerCancer19817459811Yes
107718281828.00.00.0The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. G S ManningQ Rev Biophys1978353876No
107818281828.037.8437.8Signalling pathways of the TNF superfamily: a double-edged sword. Bharat B AggarwalNat Rev Immunol200312949498No
107936561828.0121.460.7Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. Jeng-Da Chai, Martin Head-GordonPhys Chem Chem Phys200818989472Yes
108018241824.00.00.0A simple fluorometric assay for lipoperoxide in blood plasma. K YagiBiochem Med1976962904Yes
108172951823.80.00.0Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. D J Sahn, A DeMaria, J Kisslo, A WeymanCirculation1978709763Yes
108218231823.068.2768.3Physiological aspects of primary hypertension. B FolkowPhysiol Rev19826461865No
108318221822.046.7246.7Determination and analysis of urea and guanidine hydrochloride denaturation curves. C N PaceMethods Enzymol19863773761Yes
108418181818.049.1549.1Hepatitis B virus infection. W M LeeN Engl J Med19979392700No
108536361818.072.1836.1Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. M Karin, Y Ben-NeriahAnnu Rev Immunol200010837071No
1086163591817.71038.97115.4Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie BrayInt J Cancer201525220842Yes
108718161816.049.9550.0Mechanisms of hepatic fibrogenesis. Scott L FriedmanGastroenterology200818471545No
1088163431815.9366.4940.7Cytoscape: a software environment for integrated models of biomolecular interaction networks. Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey IdekerGenome Res200314597658Yes
108918151815.053.6453.6The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. G P ChrousosN Engl J Med19957715646No
109018151815.053.1753.2Accurate Coulomb-fitting basis sets for H to Rn. Florian WeigendPhys Chem Chem Phys200616633586Yes
109136291814.50.00.0Polymyositis and dermatomyositis (first of two parts). A Bohan, J B PeterN Engl J Med19751090839No
1092145151814.4413.2351.7Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A ErlichScience19882448875Yes
109318141814.046.1246.1Cancer chemoprevention with dietary phytochemicals. Young-Joon SurhNat Rev Cancer200314570043No
109418131813.00.00.0A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. D A RobinsonIEEE Trans Biomed Eng196314121113Yes
109518121812.062.3262.3Keratoconus. Y S RabinowitzSurv Ophthalmol19989493273No
109618101810.040.8740.9Theta oscillations in the hippocampus. György BuzsákiNeuron200211832222No
109718101810.056.556.5Hazards of heavy metal contamination. Lars JärupBr Med Bull200314757716No
109836171808.5139.6969.8The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. P F Lovibond, S H LovibondBehav Res Ther19957726811Yes
109918071807.060.0560.0Social cognitive theory: an agentic perspective. A BanduraAnnu Rev Psychol200111148297Yes
110054181806.0176.8358.9Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. C Lord, M Rutter, A Le CouteurJ Autism Dev Disord19947814313Yes
110118041804.039.1139.1Thrombin signalling and protease-activated receptors. S R CoughlinNature200011001069No
110218041804.034.7734.8Automated electron microscope tomography using robust prediction of specimen movements. David N MastronardeJ Struct Biol200516182563Yes
110336041802.0167.4183.7The Health Belief Model: a decade later. N K Janz, M H BeckerHealth Educ Q19846392204No
110418021802.036.9537.0Systems biology: a brief overview. Hiroaki KitanoScience200211872829No
110536041802.094.4147.2The endophenotype concept in psychiatry: etymology and strategic intentions. Irving I Gottesman, Todd D GouldAm J Psychiatry200312668349No
110618011801.048.3348.3Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. R D Pascual-MarquiMethods Find Exp Clin Pharmacol200212575463No
110718011801.046.7646.8Dopamine, learning and motivation. Roy A WiseNat Rev Neurosci200415152198No
110854031801.0148.8149.6Canonical sampling through velocity rescaling. Giovanni Bussi, Davide Donadio, Michele ParrinelloJ Chem Phys200717212484Yes
110917961796.040.0840.1The immunopathogenesis of sepsis. Jonathan CohenNature200212490963No
111017961796.00.00.0The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. S HestrinJ Biol Chem194918133390Yes
111153831794.3136.6845.6Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Z N Oltvai, C L Milliman, S J KorsmeyerCell19938358790Yes
111217931793.049.749.7A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. P J GoodfordJ Med Chem19853892003Yes
111335851792.5163.3681.7The Brief Symptom Inventory: an introductory report. L R Derogatis, N MelisaratosPsychol Med19836622612Yes
111417921792.059.4259.4Heavy metal intensification of DAB-based HRP reaction product. J C AdamsJ Histochem Cytochem19817252134Yes
111517911791.00.00.0A classification of hand preference by association analysis. M AnnettBr J Psychol19705457503Yes
111653731791.0114.8438.3EMBOSS: the European Molecular Biology Open Software Suite. P Rice, I Longden, A BleasbyTrends Genet200010827456Yes
111735811790.593.5346.8Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Michael T Lin, M Flint BealNature200617051205No
111817901790.041.0341.0Cellular mechanisms of insulin resistance. G I ShulmanJ Clin Invest200010903330No
111917901790.036.9537.0Antiviral actions of interferons. C E SamuelClin Microbiol Rev200111585785No
112053671789.0125.8241.9A new statistical method for haplotype reconstruction from population data. M Stephens, N J Smith, P DonnellyAm J Hum Genet200111254454Yes
112117891789.00.00.0The measurement of volume changes in human limbs. R J WhitneyJ Physiol195313085295Yes
112217881788.060.660.6Physiological actions of taurine. R J HuxtablePhysiol Rev19921731369No
112317861786.037.0137.0DNA topoisomerases: structure, function, and mechanism. J J ChampouxAnnu Rev Biochem200111395412No
112417861786.050.7750.8The physiology of glucagon-like peptide 1. Jens Juul HolstPhysiol Rev200717928588No
112553561785.3178.7659.6AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. P G Reeves, F H Nielsen, G C FaheyJ Nutr19938229312No
112617851785.00.00.0High-speed scanning in human memory. S SternbergScience19665939936Yes
112771371784.20.00.0Antibiotic susceptibility testing by a standardized single disk method. A W Bauer, W M Kirby, J C Sherris, M TurckAm J Clin Pathol19665325707Yes
112817841784.041.3241.3DNA topoisomerases. J C WangAnnu Rev Biochem19968811192No
112971341783.5241.660.4Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. A J Hughes, S E Daniel, L Kilford, A J LeesJ Neurol Neurosurg Psychiatry19921564476Yes
113017831783.043.8143.8The mitochondrial permeability transition pore and its role in cell death. M CromptonBiochem J199910393078No
113117831783.039.7839.8TRP channels as cellular sensors. David E ClaphamNature200314654832No
113217831783.062.6262.6The free-energy principle: a unified brain theory? Karl FristonNat Rev Neurosci201020068583No
113353481782.7155.751.9Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. F E Harrell, K L Lee, D B MarkStat Med19968668867No
113417811781.00.00.0Estimability and estimation in case-referent studies. O MiettinenAm J Epidemiol19761251836Yes
113517811781.042.1542.1Global cancer statistics in the year 2000. D M ParkinLancet Oncol200111905707No
113617811781.046.2946.3The hydrogen bond in the solid state. Thomas SteinerAngew Chem Int Ed Engl200212491444Yes
113735601780.0119.6859.8Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. R A DeFronzo, E FerranniniDiabetes Care19912044434No
113817801780.048.5848.6Accurate description of van der Waals complexes by density functional theory including empirical corrections. Stefan GrimmeJ Comput Chem200415224390Yes
113953401780.0174.8258.3The brain's default network: anatomy, function, and relevance to disease. Randy L Buckner, Jessica R Andrews-Hanna, Daniel L SchacterAnn N Y Acad Sci200818400922No
114017791779.00.00.0A theory of cerebellar cortex. D MarrJ Physiol19695784296Yes
114135571778.50.00.0Mathematical model for studying genetic variation in terms of restriction endonucleases. M Nei, W H LiProc Natl Acad Sci U S A1979291943Yes
114217781778.088.1988.2Performance-oriented assessment of mobility problems in elderly patients. M E TinettiJ Am Geriatr Soc19863944402Yes
114317761776.066.0566.0Why patients use alternative medicine: results of a national study. J A AstinJAMA19989605899Yes
114435491774.50.00.0Maturation of the head of bacteriophage T4. I. DNA packaging events. U K Laemmli, M FavreJ Mol Biol19734204102Yes
114517741774.059.5559.5Sick individuals and sick populations. G RoseInt J Epidemiol19853872850Yes
114617711771.067.1567.2Recognition-by-components: a theory of human image understanding. Irving BiedermanPsychol Rev19873575582Yes
114717711771.00.00.0The influence of some cations on an adenosine triphosphatase from peripheral nerves. J C SkouBiochim Biophys Acta195713412736Yes
114817711771.038.8538.9The complex language of chromatin regulation during transcription. Shelley L BergerNature200717522673No
114935411770.574.6637.3Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. C D Nobes, A HallCell19957536630Yes
115035411770.5124.5862.3Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. M H Zweig, G CampbellClin Chem19938472349No
115135371768.50.00.0Multiple receptors for dopamine. J W Kebabian, D B CalneNature1979215920No
115217681768.00.00.0Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. U UngerstedtActa Physiol Scand Suppl19714332693Yes
115370691767.2281.2970.3A simple technique for quantitation of low levels of DNA damage in individual cells. N P Singh, M T McCoy, R R Tice, E L SchneiderExp Cell Res19883345800Yes
115417671767.036.8136.8Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. R J KaufmanGenes Dev199910346810No
115517671767.045.5745.6DAMPs, PAMPs and alarmins: all we need to know about danger. Marco E BianchiJ Leukoc Biol200717032697No
115617651765.051.7751.8Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. A DunaifEndocr Rev19979408743No
115717651765.032.9432.9Mechanisms of alternative pre-messenger RNA splicing. Douglas L BlackAnnu Rev Biochem200312626338No
115870561764.0175.8344.0Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. A Shevchenko, M Wilm, O Vorm, M MannAnal Chem19968779443Yes
115917631763.044.9344.9The global health burden of infection-associated cancers in the year 2002. Donald Maxwell ParkinInt J Cancer200616404738Yes
116070451761.2271.8868.0The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. T F Heatherton, L T Kozlowski, R C Frecker, K O FagerströmBr J Addict19911932883Yes
116117611761.044.7244.7The dawning era of polymer therapeutics. Ruth DuncanNat Rev Drug Discov200312750738No
116235211760.5122.0961.0Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. G Di Chiara, A ImperatoProc Natl Acad Sci U S A19882899326Yes
116317601760.045.7445.7Negative refraction makes a perfect lens PendryPhys Rev Lett200011041972Yes
116417601760.058.6358.6TGFβ signalling in context. Joan MassaguéNat Rev Mol Cell Biol201222992590No
116552751758.3104.434.8Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Jason D Fontenot, Marc A Gavin, Alexander Y RudenskyNat Immunol200312612578Yes
116635141757.085.7642.9Protein folding in the cell. M J Gething, J SambrookNature19921731198No
116717571757.00.00.0On respiratory impairment in cancer cells. O WarburgScience195613351639Yes
116817541754.045.545.5Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Fiona TurnbullLancet200314615107Yes
116917531753.062.0362.0The role of hormone receptors and GTP-regulatory proteins in membrane transduction. M RodbellNature19806101906Yes
117017531753.037.0137.0An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. R M EsnoufJ Mol Graph Model19979385560Yes
117117531753.039.8139.8A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. J SantaLuciaProc Natl Acad Sci U S A19989465037Yes
117252571752.3258.8386.3HISAT: a fast spliced aligner with low memory requirements. Daehwan Kim, Ben Langmead, Steven L SalzbergNat Methods201525751142Yes
117317521752.047.847.8G proteins and dual control of adenylate cyclase. A G GilmanCell19846321035Yes
117417521752.047.247.2A theory of cortical responses. Karl FristonPhilos Trans R Soc Lond B Biol Sci200515937014No
117535011750.593.0746.5Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. K D McCarthy, J de VellisJ Cell Biol19806248568Yes
117617491749.046.0246.0Interfaces and the driving force of hydrophobic assembly. David ChandlerNature200516193038No
117752421747.3209.5869.9featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Yang Liao, Gordon K Smyth, Wei ShiBioinformatics201424227677Yes
117817471747.051.1551.1Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Gökhan S HotamisligilCell201020303879No
117917441744.058.3458.3Health consequences of intimate partner violence. Jacquelyn C CampbellLancet200211965295No
118017431743.060.1260.1Guided Search 2.0 A revised model of visual search. J M WolfePsychon Bull Rev199424203471Yes
118152261742.0131.4643.8APE: Analyses of Phylogenetics and Evolution in R language. Emmanuel Paradis, Julien Claude, Korbinian StrimmerBioinformatics200414734327Yes
118234821741.00.00.0A complementation analysis of the restriction and modification of DNA in Escherichia coli. H W Boyer, D Roulland-DussoixJ Mol Biol19694896022Yes
118317411741.045.0545.0Drug-like properties and the causes of poor solubility and poor permeability. C A LipinskiJ Pharmacol Toxicol Methods200011274893No
118417411741.00.00.0A personality scale of manifest anxiety. J A TaylorJ Abnorm Psychol195313052352Yes
118517401740.058.8558.9Drugs of abuse: anatomy, pharmacology and function of reward pathways. G F KoobTrends Pharmacol Sci19921604710No
118634771738.5160.8780.4Multiwfn: a multifunctional wavefunction analyzer. Tian Lu, Feiwu ChenJ Comput Chem201222162017Yes
118717381738.00.00.0The etiology of chondromalacia patellae. R E OuterbridgeJ Bone Joint Surg Br196114038135Yes
118817371737.042.842.8Metabolomics--the link between genotypes and phenotypes. Oliver FiehnPlant Mol Biol200211860207No
118917361736.081.6381.6Determinants of low birth weight: methodological assessment and meta-analysis. M S KramerBull World Health Organ19873322602No
119017361736.048.7948.8New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. R Y TsienBiochemistry19806770893Yes
119117361736.042.3442.3Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. B L WajchenbergEndocr Rev200011133069No
1192190951735.9422.3238.4Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P MesirovProc Natl Acad Sci U S A200516199517Yes
119317351735.040.0440.0Steroid receptor regulated transcription of specific genes and gene networks. K R YamamotoAnnu Rev Genet19853909942No
119434691734.566.6733.3Rho GTPases in cell biology. Sandrine Etienne-Manneville, Alan HallNature200212478284No
119517331733.00.00.0Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. M J CasadabanJ Mol Biol1976781293Yes
119617331733.062.162.1A cortical network for directed attention and unilateral neglect. M M MesulamAnn Neurol19817032417No
119717301730.00.00.0Comparison of the predicted and observed secondary structure of T4 phage lysozyme. B W MatthewsBiochim Biophys Acta19751180967Yes
119817301730.044.8244.8The pathophysiology of tumor necrosis factors. P VassalliAnnu Rev Immunol19921590993No
119917291729.046.346.3Interleukin-6: an overview. J Van SnickAnnu Rev Immunol19902188664No
120051841728.0172.3957.5Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. L Excoffier, P E Smouse, J M QuattroGenetics19921644282Yes
120117271727.056.5356.5Calculation of substrate oxidation rates in vivo from gaseous exchange. K N FraynJ Appl Physiol Respir Environ Exerc Physiol19836618956Yes
120217261726.054.9354.9An overview of brominated flame retardants in the environment. Cynthia A de WitChemosphere200211999784No
120351691723.0113.3437.8Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. A Nicholls, K A Sharp, B HonigProteins19911758883Yes
120417231723.039.1539.1The synaptic vesicle cycle: a cascade of protein-protein interactions. T C SüdhofNature19957791897No
120517221722.093.8793.9The assessment of clinical skills/competence/performance. G E MillerAcad Med19902400509Yes
120617211721.062.4862.5Cyclosporine. B D KahanN Engl J Med19892687689No
120717211721.067.9668.0Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. H U WittchenJ Psychiatr Res19948064641No
120817211721.048.5348.5The extracellular matrix: not just pretty fibrils. Richard O HynesScience200919965464No
120934401720.093.4146.7Prediction of protein antigenic determinants from amino acid sequences. T P Hopp, K R WoodsProc Natl Acad Sci U S A19816167991Yes
121034401720.087.6243.8Measuring the thickness of the human cerebral cortex from magnetic resonance images. B Fischl, A M DaleProc Natl Acad Sci U S A200010984517Yes
121117201720.038.2438.2Developmental regulation of the growth plate. Henry M KronenbergNature200312748651No
121251591719.7170.4556.8Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. R L Spitzer, K Kroenke, J B WilliamsJAMA199910568646Yes
121334391719.576.3438.2Cell death: critical control points. Nika N Danial, Stanley J KorsmeyerCell200414744432No
121417191719.0101.52101.5Determination and quantification of content validity. M R LynnNurs Res19863640358Yes
121517191719.00.00.0Positional information and the spatial pattern of cellular differentiation. L WolpertJ Theor Biol19694390734Yes
121634381719.088.6444.3The biology of vascular endothelial growth factor. N Ferrara, T Davis-SmythEndocr Rev19979034784No
121717191719.072.6172.6The Resonating Valence Bond State in La2CuO4 and Superconductivity. P W AndersonScience198717818979Yes
121817191719.043.4443.4Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Jeffrey A EngelmanNat Rev Cancer200919629070No
121917171717.00.00.0ATPase activity of myosin correlated with speed of muscle shortening. M BárányJ Gen Physiol19674227924Yes
122017171717.032.732.7CD4+ CD25+ suppressor T cells: more questions than answers. Ethan M ShevachNat Rev Immunol200212093005No
122117171717.035.0135.0Notch signalling: a simple pathway becomes complex. Sarah J BrayNat Rev Mol Cell Biol200616921404No
122251491716.3135.6445.2Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. G S Hotamisligil, N S Shargill, B M SpiegelmanScience19937678183Yes
122317161716.00.00.0Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. J N DumontJ Morphol19724109871Yes
122468621715.5148.1737.0WebLogo: a sequence logo generator. Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E BrennerGenome Res200415173120Yes
122551431714.3232.1777.4Some statistical methods useful in circulation research. S Wallenstein, C L Zucker, J L FleissCirc Res19807379260Yes
122617141714.040.3840.4Neutrophils and immunity: challenges and opportunities. Carl NathanNat Rev Immunol200616498448No
122717121712.033.8133.8Approaching the asymptote? Evolution and revolution in immunology. C A JanewayCold Spring Harb Symp Quant Biol19892700931No
122817111711.00.00.0The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. R RossJ Cell Biol19714327464Yes
1229119761710.9277.5439.6Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank SpelemanGenome Biol200212184808Yes
123017101710.00.00.0Dynamic properties of mammalian skeletal muscles. R I ClosePhysiol Rev19724256989No
123168341708.5133.4733.4Transformation of intact yeast cells treated with alkali cations. H Ito, Y Fukuda, K Murata, A KimuraJ Bacteriol19836336730Yes
123217081708.00.00.0The statistical analysis of enzyme kinetic data. W W ClelandAdv Enzymol Relat Areas Mol Biol19674881884No
123317081708.046.346.3Follicular helper CD4 T cells (TFH). Shane CrottyAnnu Rev Immunol201121314428No
123434151707.50.00.0The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. A E Bolton, W M HunterBiochem J19734733239Yes
123568251706.2243.6960.9A brief measure for assessing generalized anxiety disorder: the GAD-7. Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd LöweArch Intern Med200616717171Yes
123617061706.036.4736.5Structure and regulation of voltage-gated Ca2+ channels. W A CatterallAnnu Rev Cell Dev Biol200011031246No
123717031703.054.1154.1Social determinants of health inequalities. Michael MarmotLancet200515781105Yes
123834031701.590.7945.4Cloned glutamate receptors. M Hollmann, S HeinemannAnnu Rev Neurosci19948210177No
123917001700.00.00.0Protein denaturation. C TanfordAdv Protein Chem19684882248No
124017001700.043.2543.2Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. D LavanchyJ Viral Hepat200414996343No
124116991699.00.00.0Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. E M WitkinBacteriol Rev1976795416No
124233961698.093.6946.8Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. K B Mullis, F A FaloonaMethods Enzymol19873431465Yes
124316971697.00.00.0Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. M Wong-RileyBrain Res1979223730Yes
124416971697.00.00.0A graphic method for the determination and presentation of binding parameters in a complex system. H E RosenthalAnal Biochem19676048188Yes
124516961696.057.0857.1Epidemiological features of chronic low-back pain. G B AnderssonLancet199910470716No
124616951695.054.554.5Glutamate: a neurotransmitter in mammalian brain. F FonnumJ Neurochem19846139418No
124716941694.063.4963.5Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. D R JaneroFree Radic Biol Med19902079232No
124833881694.072.4336.2Identification of common molecular subsequences. T F Smith, M S WatermanJ Mol Biol19817265238Yes
124916941694.035.7235.7MicroRNA biogenesis: coordinated cropping and dicing. V Narry KimNat Rev Mol Cell Biol200515852042No
125016941694.042.0142.0Integrating cell-signalling pathways with NF-kappaB and IKK function. Neil D PerkinsNat Rev Mol Cell Biol200717183360No
125116931693.038.2938.3The distribution of secondary growths in cancer of the breast. 1889. S PagetCancer Metastasis Rev19892673568No
125216931693.044.6444.6Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. G C WalkerMicrobiol Rev19846371470No
125333831691.586.2443.1Matrix metalloproteinases. H Nagase, J F WoessnerJ Biol Chem199910419448No
125416911691.058.0958.1Large-scale neurocognitive networks and distributed processing for attention, language, and memory. M M MesulamAnn Neurol19902260847No
125516911691.00.00.0Method for the determination of hexosamines in tissues. N F BoasJ Biol Chem195313117829Yes
125616891689.056.656.6Pineal melatonin: cell biology of its synthesis and of its physiological interactions. R J ReiterEndocr Rev19911649044No
125716891689.045.7545.8Integrins. E RuoslahtiJ Clin Invest19911985087No
125816891689.054.2654.3Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. M ZasloffProc Natl Acad Sci U S A19873299384Yes
125916891689.00.00.0Transplacental carcinogenesis by stilbestrol. J FolkmanN Engl J Med19715556579Yes
126033771688.50.00.0A "Direct-Coloring" Thiocholine Method For Cholinesterases. M J Karnovsky, L RootsJ Histochem Cytochem196414187330Yes
126116871687.00.00.0Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. A F HabeebAnal Biochem19664161471Yes
126216871687.057.8757.9Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. C E MogensenN Engl J Med19846690964Yes
126316871687.00.00.0Dendritic organization in the neurons of the visual and motor cortices of the cat. D A ShollJ Anat195313117757Yes
126416861686.031.7631.8How eukaryotic transcriptional activators work. M PtashneNature19883050531No
126550581686.0100.1133.4Surfing the p53 network. B Vogelstein, D Lane, A J LevineNature200011099028No
126616861686.036.4136.4Mechanisms of cancer drug resistance. Michael M GottesmanAnnu Rev Med200211818492No
126716861686.036.4236.4Molecular regulation of vessel maturation. Rakesh K JainNat Med200312778167No
126816841684.00.00.0Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. A KrishanJ Cell Biol197549354Yes
126916841684.044.8144.8Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Scott L FriedmanPhysiol Rev200818195085No
127033651682.596.4648.2Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. Kresse, HafnerPhys Rev B Condens Matter199410010505Yes
127116821682.040.6940.7The molecular genetics of cancer. J M BishopScience19873541204No
127216811681.00.00.0Why genes in pieces? W GilbertNature1978622185Yes
127316811681.00.00.0Plastic Embedding Mixtures For Use In Electron Microscopy. H H MollenhauerStain Technol196414127791Yes
1274168011680.1534.0853.4Measurement of protein using bicinchoninic acid. P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C KlenkAnal Biochem19853843705Yes
1275117611680.1295.5942.2Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya YamanakaCell200718035408Yes
127616801680.00.00.0The theory and applications of the exchange of inert gas at the lungs and tissues. S S KetyPharmacol Rev195114833874Yes
127716791679.040.9340.9Type III protein secretion systems in bacterial pathogens of animals and plants. C J HueckMicrobiol Mol Biol Rev19989618447No
127833561678.0149.4774.7The MOS social support survey. C D Sherbourne, A L StewartSoc Sci Med19912035047Yes
127933561678.00.00.0Receptive fields and functional architecture of monkey striate cortex. D H Hubel, T N WieselJ Physiol19684966457Yes
128016741674.00.00.0Evolutionary rate at the molecular level. M KimuraNature19685637732Yes
128133481674.094.2647.1Biochemistry of multidrug resistance mediated by the multidrug transporter. M M Gottesman, I PastanAnnu Rev Biochem19938102521No
128216741674.00.00.0The general adaptation syndrome and the diseases of adaptation. H SelyeJ Clin Endocrinol Metab194621025115Yes
128316741674.077.1677.2Role of nrf2 in oxidative stress and toxicity. Qiang MaAnnu Rev Pharmacol Toxicol201323294312No
128416731673.070.4670.5Perception of risk. P SlovicScience19873563507Yes
128516731673.00.00.0An improved procedure for serum creatine phosphokinase determination. S B RosalkiJ Lab Clin Med19674381359Yes
128650181672.7115.9538.6Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Michael W Pfaffl, Graham W Horgan, Leo DempfleNucleic Acids Res200211972351Yes
128716721672.048.2848.3Biofilms: microbial life on surfaces. Rodney M DonlanEmerg Infect Dis200212194761No
128816711671.00.00.0Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. J A MillerCancer Res19704915745No
128933411670.5132.5566.3The biofilm matrix. Hans-Curt Flemming, Jost WingenderNat Rev Microbiol201020676145No
129016701670.060.9360.9Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). G G GlennerN Engl J Med19806154243No
129183491669.8233.0946.6Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary KingDiabetes Care200415111519Yes
129266781669.50.00.0Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. E A Jaffe, R L Nachman, C G Becker, C R MinickJ Clin Invest19734355998Yes
129316691669.00.00.0Drugs which inhibit prostaglandin biosynthesis. R J FlowerPharmacol Rev19744208101Yes
129433381669.00.00.0The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. T Omura, R SatoJ Biol Chem196414209972Yes
129516691669.00.00.0Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. J SpizizenProc Natl Acad Sci U S A195816590310Yes
129616661666.040.5740.6Evolutionary relationship of DNA sequences in finite populations. F TajimaGenetics19836628982Yes
129716661666.069.8469.8Doxil®--the first FDA-approved nano-drug: lessons learned. Yechezkel BarenholzJ Control Release201222484195No
129816641664.052.8252.8The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. B L FredricksonAm Psychol200111315248Yes
129916641664.00.00.0Chromatographic Separation Of Human Brain Gangliosides. L SvennerholmJ Neurochem196314066623Yes
130016631663.058.1958.2Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. A H ConneyCancer Res19826814745No
130116631663.039.7939.8Fabrication of novel biomaterials through molecular self-assembly. Shuguang ZhangNat Biotechnol200314520402No
130216631663.035.4335.4DNA methylation and human disease. Keith D RobertsonNat Rev Genet200516136652No
130316611661.00.00.0Areas, volumes, packing and protein structure. F M RichardsAnnu Rev Biophys Bioeng1977326146No
130433221661.00.00.0Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. M Grunstein, D S HognessProc Natl Acad Sci U S A19751105573Yes
130516611661.056.2556.2The crisis in antibiotic resistance. H C NeuScience19921509257No
130616611661.067.6967.7Predicting basal metabolic rate, new standards and review of previous work. W N SchofieldHum Nutr Clin Nutr19854044297Yes
130716611661.039.3739.4Solvent-accessible surfaces of proteins and nucleic acids. M L ConnollyScience19836879170Yes
130833221661.00.00.0Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. J Marmur, P DotyJ Mol Biol196214470099Yes
130916601660.056.2856.3Serum albumin. T PetersAdv Protein Chem19853904348No
131016601660.058.2858.3Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? B HalliwellLancet19947915779No
131116601660.084.4884.5Microplastics in the marine environment. Anthony L AndradyMar Pollut Bull201121742351No
131216591659.038.8938.9The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. D M KingsleyGenes Dev19948299934No
131316591659.049.149.1Flavonoids as antioxidants. P G PiettaJ Nat Prod200010924197No
131416581658.00.00.0Mode of cell migration to the superficial layers of fetal monkey neocortex. P RakicJ Comp Neurol19724624784Yes
131516581658.037.1737.2Exploring complex networks. S H StrogatzNature200111258382No
131633111655.572.2536.1Integrin signaling. F G Giancotti, E RuoslahtiScience199910446041No
131716551655.044.7444.7What is cognitive reserve? Theory and research application of the reserve concept. Yaakov SternJ Int Neuropsychol Soc200211939702No
131816541654.00.00.0Carbonic anhydrase: chemistry, physiology, and inhibition. T H MarenPhysiol Rev19674964060No
131916541654.034.3834.4Cancer and the chemokine network. Fran BalkwillNat Rev Cancer200415229479No
132016471647.00.00.0Pedigrees of some mutant strains of Escherichia coli K-12. B J BachmannBacteriol Rev19724568763No
132116451645.037.4937.5Effects of cytochalasin and phalloidin on actin. J A CooperJ Cell Biol19873312229No
132265791644.8153.1438.3Use of T7 RNA polymerase to direct expression of cloned genes. F W Studier, A H Rosenberg, J J Dunn, J W DubendorffMethods Enzymol19902199796Yes
132332881644.085.3642.7Receptors for purines and pyrimidines. V Ralevic, G BurnstockPharmacol Rev19989755289No
132416441644.00.00.0A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. D MattinglyJ Clin Pathol196214471419Yes
132532871643.5106.5953.3Efficient pseudopotentials for plane-wave calculations. Troullier, MartinsPhys Rev B Condens Matter19919997467Yes
1326115021643.1425.2460.7Assessing the quality of reports of randomized clinical trials: is blinding necessary? A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuayControl Clin Trials19968721797Yes
132732861643.0109.1954.6Role of free radicals and catalytic metal ions in human disease: an overview. B Halliwell, J M GutteridgeMethods Enzymol19902172697No
132816431643.051.4451.4Inhibited spontaneous emission in solid-state physics and electronics. YablonovitchPhys Rev Lett198710034639Yes
132916411641.034.1634.2Structural features in eukaryotic mRNAs that modulate the initiation of translation. M KozakJ Biol Chem19911939050No
133016411641.046.6746.7Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. Robert E MarxJ Oral Maxillofac Surg200312966493Yes
133132811640.5102.7951.4Nonparametric statistical testing of EEG- and MEG-data. Eric Maris, Robert OostenveldJ Neurosci Methods200717517438Yes
133216401640.045.8645.9Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. H LeVineProtein Sci19938453378Yes
133316401640.049.7549.8Intestinal mucosal barrier function in health and disease. Jerrold R TurnerNat Rev Immunol200919855405No
133432791639.576.1538.1Amino acid substitution matrices from protein blocks. S Henikoff, J G HenikoffProc Natl Acad Sci U S A19921438297Yes
133532751637.50.00.0Method for the isolation of intact islets of Langerhans from the rat pancreas. P E Lacy, M KostianovskyDiabetes19675333500Yes
133632751637.5143.6371.8A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. J G Snodgrass, M VanderwartJ Exp Psychol Hum Learn19807373248Yes
133732751637.581.1740.6Liver fibrosis. Ramón Bataller, David A BrennerJ Clin Invest200515690074No
133816371637.044.2544.2Dengue and dengue hemorrhagic fever. D J GublerClin Microbiol Rev19989665979No
133965451636.2163.7140.9Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. C A Lipinski, F Lombardo, B W Dominy, P J FeeneyAdv Drug Deliv Rev200111259830No
134016361636.045.5345.5Turnover of inositol phospholipids and signal transduction. Y NishizukaScience19846147898No
134165391634.8272.7968.2Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanJ Clin Epidemiol200919631508No
134216341634.034.934.9The effect of infections on susceptibility to autoimmune and allergic diseases. Jean-Francois BachN Engl J Med200212239261No
134316341634.060.5660.6Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Sergio PecorelliInt J Gynaecol Obstet200919367689No
134416341634.049.649.6MYC on the path to cancer. Chi V DangCell201222464321No
134532641632.074.1937.1Monocyte and macrophage heterogeneity. Siamon Gordon, Philip R TaylorNat Rev Immunol200516322748No
134632641632.0110.8555.4Wnt/β-catenin signaling and disease. Hans Clevers, Roel NusseCell201222682243No
134732631631.588.5344.3Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering Nie, EmoryScience19979027306Yes
134816311631.052.4752.5Metallothionein. D H HamerAnnu Rev Biochem19863527054No
134965241631.0267.5266.9Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg LangBehav Res Methods200919897823Yes
135016301630.00.00.0The micronucleus test. W SchmidMutat Res197548190Yes
135132591629.578.8839.4The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. P Angel, M KarinBiochim Biophys Acta19911751545No
135232591629.586.1943.1Quantum dot bioconjugates for ultrasensitive nonisotopic detection. W C Chan, S NieScience19989748158Yes
135316291629.052.5852.6PsychoPy--Psychophysics software in Python. Jonathan W PeirceJ Neurosci Methods200717254636Yes
1354162811628.1524.052.4The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S LuthraArthritis Rheum19883358796Yes
135516281628.048.6548.6Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. E M WassermannElectroencephalogr Clin Neurophysiol19989474057No
135632561628.090.8145.4Protein structure prediction on the Web: a case study using the Phyre server. Lawrence A Kelley, Michael J E SternbergNat Protoc200919247286Yes
135716271627.038.7338.7NADPH oxidase: an update. B M BabiorBlood199910029572No
135865011625.2133.9333.5Stem cells, cancer, and cancer stem cells. T Reya, S J Morrison, M F Clarke, I L WeissmanNature200111689955No
135948731624.3165.9655.3FastTree 2--approximately maximum-likelihood trees for large alignments. Morgan N Price, Paramvir S Dehal, Adam P ArkinPLoS One201020224823Yes
136016241624.045.2945.3An index to quantify an individual's scientific research output. J E HirschProc Natl Acad Sci U S A200516275915Yes
136148701623.3156.4952.2Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. H Esterbauer, R J Schaur, H ZollnerFree Radic Biol Med19911937131No
136216231623.036.2836.3Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. S L FriedmanJ Biol Chem200010644669No
136316231623.00.00.0Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. E G GrayJ Anat195913829103Yes
136432441622.071.5835.8Protein structure comparison by alignment of distance matrices. L Holm, C SanderJ Mol Biol19938377180Yes
136516221622.040.1340.1Inflammatory bowel disease: etiology and pathogenesis. C FiocchiGastroenterology19989649475No
136616211621.051.651.6The atom economy--a search for synthetic efficiency. B M TrostScience19911962206Yes
136716211621.058.6358.6Cell damage in the brain: a speculative synthesis. B K SiesjöJ Cereb Blood Flow Metab19816276420No
136816211621.031.731.7Cellular roles of DNA topoisomerases: a molecular perspective. James C WangNat Rev Mol Cell Biol200212042765No
136916201620.00.00.0RNA-dependent DNA polymerase in virions of RNA tumour viruses. D BaltimoreNature19704316300Yes
137016201620.032.2532.2Hox genes in vertebrate development. R KrumlaufCell19947913880No
137116191619.032.432.4Cell cycle checkpoints: preventing an identity crisis. S J ElledgeScience19968939848No
137216191619.045.1145.1Oxidative stress hypothesis in Alzheimer's disease. W R MarkesberyFree Radic Biol Med19979165306No
137316191619.045.7245.7The comet assay for DNA damage and repair: principles, applications, and limitations. Andrew R CollinsMol Biotechnol200415004294No
137432371618.5100.8150.4Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. F Denizot, R LangJ Immunol Methods19863486233Yes
137564741618.5177.3444.3Epithelial-mesenchymal transitions in development and disease. Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela NietoCell200919945376No
137616181618.049.0549.0Extracellular ATP: effects, sources and fate. J L GordonBiochem J19863006665No
137732351617.596.0448.0The inflammasomes. Kate Schroder, Jurg TschoppCell201020303873No
137832341617.079.7539.9PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. Alexander W Schüttelkopf, Daan M F van AaltenActa Crystallogr D Biol Crystallogr200415272157Yes
137932311615.50.00.0New method for quantitative determination of uronic acids. N Blumenkrantz, G Asboe-HansenAnal Biochem19734269305Yes
138016151615.046.5546.5Cell biology and molecular basis of denitrification. W G ZumftMicrobiol Mol Biol Rev19979409151No
138116141614.041.2341.2Episodic memory: from mind to brain. Endel TulvingAnnu Rev Psychol200211752477Yes
138216141614.054.9755.0Global epidemiology of oral and oropharyngeal cancer. Saman WarnakulasuriyaOral Oncol200918804401No
138316131613.041.8941.9Neurotrophins and neuronal plasticity. H ThoenenScience19957570017No
138416131613.041.141.1Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Paul M RidkerCirculation200312551853No
138516131613.044.8744.9Chlorpromazine equivalent doses for the newer atypical antipsychotics. Scott W WoodsJ Clin Psychiatry200312823080No
138616121612.070.6670.7Neurogenetic adaptive mechanisms in alcoholism. C R CloningerScience19872882604Yes
138716121612.037.0537.0Cellular oncogenes and retroviruses. J M BishopAnnu Rev Biochem19836351725No
138832221611.0127.7663.9Assays of glutathione peroxidase. L Flohé, W A GünzlerMethods Enzymol19846727659Yes
138932201610.00.00.0A fluorometric method for determination of oxidized and reduced glutathione in tissues. P J Hissin, R HilfAnal Biochem1976962076Yes
139016101610.067.4667.5Negative symptoms in schizophrenia. Definition and reliability. N C AndreasenArch Gen Psychiatry19827165477Yes
139132181609.085.3942.7Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Christian Haass, Dennis J SelkoeNat Rev Mol Cell Biol200717245412No
139216081608.050.8450.8Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. D W ChoiTrends Neurosci19882469166No
139396471607.8278.5846.4Positional cloning of the mouse obese gene and its human homologue. Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M FriedmanNature19947984236Yes
139432111605.575.7237.9Parkinson's disease: mechanisms and models. William Dauer, Serge PrzedborskiNeuron200312971891No
139516041604.043.3143.3Using circular dichroism spectra to estimate protein secondary structure. Norma J GreenfieldNat Protoc200617406547Yes
139632071603.589.3944.7Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. Steven E Nissen, Kathy WolskiN Engl J Med200717517853Yes
139716031603.00.00.0Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. O OuchterlonyActa Pathol Microbiol Scand195313079779Yes
139816031603.044.8344.8Network pharmacology: the next paradigm in drug discovery. Andrew L HopkinsNat Chem Biol200818936753No
139932051602.577.1838.6Rapid and sensitive protein similarity searches. D J Lipman, W R PearsonScience19852983426Yes
140016021602.047.2147.2Metalloproteinases and their inhibitors in matrix remodeling. L M MatrisianTrends Genet19902132731No
140180081601.6210.6842.1Mapping and quantifying mammalian transcriptomes by RNA-Seq. Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara WoldNat Methods200818516045Yes
140216011601.00.00.0Chromatin structure: a repeating unit of histones and DNA. R D KornbergScience19744825889Yes
140316011601.050.5250.5A measure of population subdivision based on microsatellite allele frequencies. M SlatkinGenetics19957705646Yes
140416011601.029.8629.9Maximum-likelihood density modification. T C TerwilligerActa Crystallogr D Biol Crystallogr200010944333Yes
140531961598.00.00.0Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. M Mihara, M UchiyamaAnal Biochem1978655387Yes
140615981598.035.2335.2Bone morphogenetic proteins: multifunctional regulators of vertebrate development. B L HoganGenes Dev19968682290No
140715981598.043.5743.6The genetics of ageing. Cynthia J KenyonNature201020336132No
140815971597.030.3330.3Cyclin-dependent kinases: engines, clocks, and microprocessors. D O MorganAnnu Rev Cell Dev Biol19979442875No
140915961596.036.9336.9VLA proteins in the integrin family: structures, functions, and their role on leukocytes. M E HemlerAnnu Rev Immunol19902188667No
141031911595.592.3646.2ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. B Ravel, M NewvilleJ Synchrotron Radiat200515968136Yes
141131891594.50.00.0Variations in the pattern of pubertal changes in boys. W A Marshall, J M TannerArch Dis Child19705440182Yes
141231891594.563.3331.7Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. M E Greenberg, E B ZiffNature19846090941Yes
141331871593.563.7831.9Automated MAD and MIR structure solution. T C Terwilliger, J BerendzenActa Crystallogr D Biol Crystallogr199910089316Yes
141415921592.055.8655.9Grounded cognition. Lawrence W BarsalouAnnu Rev Psychol200817705682No
141531781589.089.5544.8The mirror-neuron system. Giacomo Rizzolatti, Laila CraigheroAnnu Rev Neurosci200415217330No
141615871587.031.6831.7An analysis of vertebrate mRNA sequences: intimations of translational control. M KozakJ Cell Biol19911955461No
141715871587.048.348.3Classification of inflammatory bowel disease. J E Lennard-JonesScand J Gastroenterol Suppl19892617184Yes
141831711585.591.2345.6Biofilms: survival mechanisms of clinically relevant microorganisms. Rodney M Donlan, J William CostertonClin Microbiol Rev200211932229No
141915851585.037.8137.8Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. S A BustinJ Mol Endocrinol200212200227No
142015841584.057.7357.7Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. P HolzerPharmacol Rev19911852779No
142131681584.0113.3856.7Avoiding false positives with PCR. S Kwok, R HiguchiNature19892716852Yes
142215841584.00.00.0The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. A G PearseJ Histochem Cytochem19694143745No
142315841584.00.00.0Structural considerations in the interaction of DNA and acridines. L S LermanJ Mol Biol196113761054Yes
142415831583.00.00.0Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. K O FagerströmAddict Behav1978735910Yes
142515831583.039.9840.0Tumor necrosis factor (TNF). L J OldScience19852413547Yes
142615831583.034.6734.7The caveolae membrane system. R G AndersonAnnu Rev Biochem19989759488No
142731621581.078.2639.1CAP3: A DNA sequence assembly program. X Huang, A MadanGenome Res199910508846Yes
142815801580.045.6145.6Ionic dependence of glutamate neurotoxicity. D W ChoiJ Neurosci19872880938Yes
142915801580.00.00.0Computerized transverse axial scanning (tomography). 1. Description of system. G N HounsfieldBr J Radiol19734757352Yes
143015801580.053.4853.5Number of people with glaucoma worldwide. H A QuigleyBr J Ophthalmol19968695555No
143147381579.3113.6537.9Inflammation and atherosclerosis. Peter Libby, Paul M Ridker, Attilio MaseriCirculation200211877368No
143215791579.00.00.0Interhemispheric differences in the localization of psychological processes in man. B MilnerBr Med Bull19714937273No
143315791579.032.9533.0The synaptic vesicle cycle. Thomas C SudhofAnnu Rev Neurosci200415217342No
143415791579.040.7440.7Angiogenesis: an organizing principle for drug discovery? Judah FolkmanNat Rev Drug Discov200717396134No
143531571578.568.1734.1Inhibitors of mammalian G1 cyclin-dependent kinases. C J Sherr, J M RobertsGenes Dev19957758941No
1436110451577.9286.4840.9Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M NathanN Engl J Med200211832527Yes
143731551577.578.1939.1A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. S Tabor, C C RichardsonProc Natl Acad Sci U S A19853156376Yes
143863021575.5171.2642.8Cancer-related inflammation. Alberto Mantovani, Paola Allavena, Antonio Sica, Frances BalkwillNature200818650914No
143915751575.041.5341.5Alpha-crystallin can function as a molecular chaperone. J HorwitzProc Natl Acad Sci U S A19921438232Yes
144015751575.053.953.9Hypoxia-inducible factors in physiology and medicine. Gregg L SemenzaCell201222304911No
144115731573.046.346.3Perceptual symbol systems. L W BarsalouBehav Brain Sci199911301525No
144215721572.034.5734.6Excitatory actions of gaba during development: the nature of the nurture. Yehezkel Ben-AriNat Rev Neurosci200212209121No
144315721572.048.7748.8Infrared spectroscopy of proteins. Andreas BarthBiochim Biophys Acta200717692815No
144431441572.091.645.8Building better batteries. M Armand, J-M TarasconNature200818256660No
144531431571.563.5831.8SIFT: Predicting amino acid changes that affect protein function. Pauline C Ng, Steven HenikoffNucleic Acids Res200312824425Yes
144631421571.088.5144.3Polyamines. C W Tabor, H TaborAnnu Rev Biochem19846206782No
144715701570.00.00.0Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. B HilleJ Gen Physiol1977300786Yes
144815701570.052.452.4Biology of interleukin 1. C A DinarelloFASEB J19883277884No
144947081569.3104.5334.8Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. J E Darnell, I M Kerr, G R StarkScience19948197455No
145031381569.0140.2870.1miRBase: annotating high confidence microRNAs using deep sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201424275495Yes
145147061568.7145.6948.6Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. P A Wolf, R D Abbott, W B KannelStroke19911866765Yes
145215681568.00.00.0Regulation of noradrenaline release by presynaptic receptor systems. K StarkeRev Physiol Biochem Pharmacol197714389No
145331351567.569.7534.9Insulin signalling and the regulation of glucose and lipid metabolism. A R Saltiel, C R KahnNature200111742412Yes
145415671567.00.00.0Paced auditory serial-addition task: a measure of recovery from concussion. D M GronwallPercept Mot Skills1977866038Yes
145515661566.00.00.0The estimation of phosphorus. R J AllenBiochem J194016747230Yes
145631311565.597.5848.8Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. D S Bredt, S H SnyderProc Natl Acad Sci U S A19901689048Yes
145715641564.072.0472.0Mood and memory. G H BowerAm Psychol19817224324Yes
145815631563.00.00.0Fluorescence energy transfer as a spectroscopic ruler. L StryerAnnu Rev Biochem1978354506No
145915631563.034.3134.3On finding all suboptimal foldings of an RNA molecule. M ZukerScience19892468181No
146015631563.061.9962.0Modeling and variable selection in epidemiologic analysis. S GreenlandAm J Public Health19892916724Yes
146115631563.00.00.0A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. B C HummelCan J Biochem Physiol195914405350Yes
146215631563.039.8939.9Tumor angiogenesis. Robert S KerbelN Engl J Med200818463380No
146315621562.055.3955.4Frontal-subcortical circuits and human behavior. J L CummingsArch Neurol19938352676No
146415621562.033.3433.3Points of control in inflammation. Carl NathanNature200212490957No
146531231561.50.00.0Convergent and discriminant validation by the multitrait-multimethod matrix. D T Campbell, D W FiskePsychol Bull195913634291Yes
146615611561.00.00.0Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. W H OldendorfAm J Physiol19715124307Yes
146715611561.041.841.8Adipose tissue, adipokines, and inflammation. Giamila FantuzziJ Allergy Clin Immunol200515867843No
146815601560.044.3844.4Leptospirosis. P N LevettClin Microbiol Rev200111292640No
146915601560.032.6432.6Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Judith CampisiCell200515734683No
147046791559.7102.3234.1A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. Zhang, Chung, OldenburgJ Biomol Screen199910838414Yes
147115591559.042.9743.0The complete general secretory pathway in gram-negative bacteria. A P PugsleyMicrobiol Rev19938096622No
147231181559.00.00.0A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. G Schmidt, S J ThannhauserJ Biol Chem194521005717Yes
147315581558.00.00.0The relationship between the spleen colony-forming cell and the haemopoietic stem cell. R SchofieldBlood Cells1978747780Yes
147415581558.034.3834.4Protein homology detection by HMM-HMM comparison. Johannes SödingBioinformatics200515531603Yes
147515581558.044.6244.6Oxidative stress and neurodegeneration: where are we now? Barry HalliwellJ Neurochem200616805774No
147615571557.035.8735.9The proto-oncogene Bcl-2 and its role in regulating apoptosis. G KroemerNat Med19979176486No
147715571557.031.5231.5Generating samples under a Wright-Fisher neutral model of genetic variation. Richard R HudsonBioinformatics200211847089Yes
147846671555.7132.9844.3Cell death: the significance of apoptosis. A H Wyllie, J F Kerr, A R CurrieInt Rev Cytol19807014501No
147946671555.7189.5163.2The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. C A McHorney, J E Ware, A E RaczekMed Care19938450681Yes
148015551555.037.437.4Recognition of microorganisms and activation of the immune response. Ruslan MedzhitovNature200717943118No
148115541554.029.8229.8Germinal centers. I C MacLennanAnnu Rev Immunol19948011279No
148215541554.051.5151.5Health consequences of obesity in youth: childhood predictors of adult disease. W H DietzPediatrics199812224658No
148331071553.594.2647.1Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. M Karas, F HillenkampAnal Chem19883239801Yes
148415531553.052.6552.6Archaea in coastal marine environments. E F DeLongProc Natl Acad Sci U S A19921608980Yes
148531021551.0207.45103.7A clinical method of functional assessment of the shoulder. C R Constant, A H MurleyClin Orthop Relat Res19873791738Yes
148646531551.0105.6835.2An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J K Eng, A L McCormack, J R YatesJ Am Soc Mass Spectrom199424226387Yes
148715501550.049.0449.0Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. F RoussetGenetics19979093870Yes
148815501550.046.1846.2Introduction and General Overview of Cyclodextrin Chemistry. József SzejtliChem Rev199811848947Yes
148946481549.3132.2544.1The metabolic syndrome--a new worldwide definition. K George M M Alberti, Paul Zimmet, Jonathan ShawLancet200516182882Yes
149015491549.040.2340.2Molecular biology of prion diseases. S B PrusinerScience19911675487No
149115491549.045.5445.5The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. R R LlinásScience19883059497No
149215491549.060.4660.5Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. P HolzerNeuroscience19883288903No
149346471549.00.00.0A highly sensitive adenylate cyclase assay. Y Salomon, C Londos, M RodbellAnal Biochem19744827395Yes
149415491549.045.2245.2Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. S HakomoriAnnu Rev Biochem19817023369No
149530971548.565.8132.9A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. D Wessel, U I FlüggeAnal Biochem19846731838Yes
149630971548.5105.1352.6Understanding interobserver agreement: the kappa statistic. Anthony J Viera, Joanne M GarrettFam Med200515883903Yes
149715481548.041.8941.9Molecular bases of the acute coronary syndromes. P LibbyCirculation19957758192No
149815471547.050.250.2Cellular defenses against damage from reactive oxygen species. B P YuPhysiol Rev19948295932No
149915461546.067.0667.1The drug abuse screening test. H A SkinnerAddict Behav19827183189Yes
150015461546.042.0942.1From sensation to cognition. M M MesulamBrain19989648540No
150115461546.061.1561.1Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. Lutz AckermannChem Rev201121391562Yes
150230921546.094.4947.2The unfolded protein response: from stress pathway to homeostatic regulation. Peter Walter, David RonScience201122116877No
150330911545.5122.8961.4The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. A J Stunkard, S MessickJ Psychosom Res19853981480Yes
150415451545.060.5760.6Simple proton spectroscopic imaging. W T DixonRadiology19846089263Yes
150515431543.038.1638.2HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. J M CoffinScience19957824947Yes
150615431543.050.4150.4The stress response in fish. S E Wendelaar BongaPhysiol Rev19979234959No
150715431543.034.1334.1Neuronal calcium signaling. M J BerridgeNeuron19989697848No
150815431543.050.0550.0Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? George A BonannoAm Psychol200414736317No
150930851542.590.6845.3Oxidative stress, glutamate, and neurodegenerative disorders. J T Coyle, P PuttfarckenScience19937901908No
151015421542.051.5151.5Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). M N MarshGastroenterology19921727768No
151130841542.090.3945.2Event-related EEG/MEG synchronization and desynchronization: basic principles. G Pfurtscheller, F H Lopes da SilvaClin Neurophysiol199910576479No
151215421542.030.4330.4Switching and signaling at the telomere. E H BlackburnCell200111572773No
151315411541.00.00.0Discharge patterns and functional organization of mammalian retina. S W KufflerJ Neurophysiol195313035466Yes
151430811540.576.8138.4Neuronal oscillations in cortical networks. György Buzsáki, Andreas DraguhnScience200415218136No
151530771538.573.0436.5Issues and challenges facing rechargeable lithium batteries. J M Tarascon, M ArmandNature200111713543Yes
151615381538.00.00.0Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. H S PenefskyJ Biol Chem197716006Yes
151715381538.039.5439.5Cellular basis of working memory. P S Goldman-RakicNeuron19957695894No
151815371537.034.7734.8Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. C TaswellJ Immunol19817009746Yes
151915371537.046.4546.5Multiple imputation: a primer. J L SchaferStat Methods Med Res199910347857No
152046101536.7103.634.5Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. M A Frohman, M K Dush, G R MartinProc Natl Acad Sci U S A19882461560Yes
152146081536.00.00.0Impact of Event Scale: a measure of subjective stress. M Horowitz, N Wilner, W AlvarezPsychosom Med1979472086Yes
152246021534.0118.2539.4Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. Earl S Ford, Wayne H Giles, William H DietzJAMA200211790215Yes
152315341534.00.00.0Antigen-Antibody Crossed Electrophoresis. C B LaurellAnal Biochem196514302464Yes
152415331533.081.6881.7Conservation of resources. A new attempt at conceptualizing stress. S E HobfollAm Psychol19892648906No
152515331533.027.527.5Cell cycle checkpoint signaling through the ATM and ATR kinases. R T AbrahamGenes Dev200111544175No
152615331533.038.4838.5The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Michael R LieberAnnu Rev Biochem201020192759No
152730651532.50.00.0The structure of coping. L I Pearlin, C SchoolerJ Health Soc Behav1978649936Yes
152815321532.044.544.5Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. A E PeggCancer Res19883123052No
152915301530.036.6136.6AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. D Grahame HardieNat Rev Mol Cell Biol200717712357No
153091781529.7217.6936.3Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuireScience19873798106Yes
153130591529.584.4842.2A scaling normalization method for differential expression analysis of RNA-seq data. Mark D Robinson, Alicia OshlackGenome Biol201020196867Yes
153215291529.038.9639.0Early signals in the mitogenic response. E RozengurtScience19863018928No
153315291529.039.3539.4Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. M J MeaneyAnnu Rev Neurosci200111520931No
153430571528.50.00.0Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. C B Lozzio, B B LozzioBlood1975163658Yes
153515271527.00.00.0An enzymic method for the trace iodination of immunoglobulins and other proteins. J J MarchalonisBiochem J19694185494Yes
153615261526.045.3945.4Recent advances in the biochemistry of polyamines in eukaryotes. A E PeggBiochem J19863087344No
153730521526.071.735.9The epigenomics of cancer. Peter A Jones, Stephen B BaylinCell200717320506No
153830511525.50.00.0New Giemsa method for the differential staining of sister chromatids. P Perry, S WolffNature19744138930Yes
153930511525.5103.8851.9The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. R Doll, R PetoJ Natl Cancer Inst19817017215No
154015251525.030.6230.6E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. J R NevinsScience19921411535Yes
154115251525.034.2434.2Molecular themes in oncogenesis. J M BishopCell19911988146No
154215251525.042.4142.4P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation. Berk HessJ Chem Theory Comput200826619985Yes
154315241524.040.9140.9Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. D A DoughertyScience19968539615No
154415241524.044.7444.7The in vitro micronucleus technique. M FenechMutat Res200011113469No
154515231523.00.00.0Dithiothreitol, A New Protective Reagent For Sh Groups. W W ClelandBiochemistry196414192894Yes
154630431521.5111.9656.0ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. M Gardes, T D BrunsMol Ecol19938180733Yes
154715201520.070.3970.4The contribution of low birth weight to infant mortality and childhood morbidity. M C McCormickN Engl J Med19853880598No
154815191519.041.5641.6Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. L A LiottaCancer Res19862998604No
154915181518.00.00.0Which elements are excited in electrical stimulation of mammalian central nervous system: a review. J B RanckBrain Res19751102064No
155015181518.027.8227.8Altering the genome by homologous recombination. M R CapecchiScience19892660260No
155115181518.038.438.4Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. Z YangJ Mol Evol19947932792Yes
155215181518.070.9170.9Measurement of health state utilities for economic appraisal. G W TorranceJ Health Econ198610311607No
155391051517.5193.332.2Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C MelloNature19989486653Yes
155415171517.043.643.6Determination of minimum inhibitory concentrations. J M AndrewsJ Antimicrob Chemother200111420333Yes
155515161516.00.00.0Calcium release from the sarcoplasmic reticulum. M EndoPhysiol Rev197713441Yes
155630321516.080.740.4Origins and Mechanisms of miRNAs and siRNAs. Richard W Carthew, Erik J SontheimerCell200919239886No
155790811513.5315.3952.6Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R TannenbaumAnal Biochem19827181105Yes
155830271513.564.3532.2Upstream and downstream of mTOR. Nissim Hay, Nahum SonenbergGenes Dev200415314020No
155930241512.0100.950.5Separate visual pathways for perception and action. M A Goodale, A D MilnerTrends Neurosci19921374953No
156015121512.036.3936.4Getting formal with dopamine and reward. Wolfram SchultzNeuron200212383780No
156130201510.00.00.0Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. D B Dill, D L CostillJ Appl Physiol19744850854Yes
156215101510.044.044.0Oxidative stress: oxidants and antioxidants. H SiesExp Physiol19979129943No
156315101510.037.837.8Python: a programming language for software integration and development. M F SannerJ Mol Graph Model199910660911Yes
156430171508.560.2630.1Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. O Tetsu, F McCormickNature199910201372Yes
156530161508.00.00.0Computed circular dichroism spectra for the evaluation of protein conformation. N Greenfield, G D FasmanBiochemistry19695346390Yes
156615081508.056.9557.0Aging, natural death, and the compression of morbidity. J F FriesN Engl J Med19807383070Yes
156715081508.029.0929.1How cells read TGF-beta signals. J MassaguéNat Rev Mol Cell Biol200011252892No
156815081508.045.2345.2Porous scaffold design for tissue engineering. Scott J HollisterNat Mater200516003400No
1569120621507.8320.7340.1Electric field effect in atomically thin carbon films. K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A FirsovScience200415499015Yes
157015071507.059.8659.9Probiotics in man and animals. R FullerJ Appl Bacteriol19892666378No
157115061506.00.00.0Biological applications of ionophores. B C PressmanAnnu Rev Biochem1976786156No
157215061506.00.00.0Some observations upon a new inhibitor of monoamine oxidase in brain tissue. J P JohnstonBiochem Pharmacol19685659776Yes
157315051505.036.0636.1Trastuzumab--mechanism of action and use in clinical practice. Clifford A HudisN Engl J Med200717611206No
157415041504.066.766.7A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. D J SchuirmannJ Pharmacokinet Biopharm19873450848Yes
157530081504.0116.2958.1Microenvironmental regulation of tumor progression and metastasis. Daniela F Quail, Johanna A JoyceNat Med201324202395No
157615031503.041.2941.3THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. Kozi AsadaAnnu Rev Plant Physiol Plant Mol Biol199915012221Yes
157715031503.052.6552.6Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Leonardo PantoniLancet Neurol201020610345No
157845061502.0183.6961.2Effect of the damping function in dispersion corrected density functional theory. Stefan Grimme, Stephan Ehrlich, Lars GoerigkJ Comput Chem201121370243Yes
157930031501.5108.7454.4Macrophage plasticity and polarization: in vivo veritas. Antonio Sica, Alberto MantovaniJ Clin Invest201222378047No
158015011501.038.0238.0Trophic factors and neuronal survival. Y A BardeNeuron19892697237No
158115011501.036.6636.7Thiazolidinediones. Hannele Yki-JärvinenN Engl J Med200415356308No
158260041501.0232.3358.1SignalP 4.0: discriminating signal peptides from transmembrane regions. Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik NielsenNat Methods201121959131Yes
158345011500.3122.3640.8Median-joining networks for inferring intraspecific phylogenies. H J Bandelt, P Forster, A RöhlMol Biol Evol199910331250Yes
158415001500.042.1742.2Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Y Ben-AriNeuroscience19852859548No
158515001500.00.00.0The inverse care law. J T HartLancet19714100731Yes
158615001500.030.0630.1Neuroblastoma: biological insights into a clinical enigma. Garrett M BrodeurNat Rev Cancer200312612655No
158714991499.047.4947.5The role of the amygdala in fear and anxiety. M DavisAnnu Rev Neurosci19921575447No
158829981499.0157.9479.0Interrater reliability of a modified Ashworth scale of muscle spasticity. R W Bohannon, M B SmithPhys Ther19873809245Yes
158914991499.044.344.3The basal ganglia: focused selection and inhibition of competing motor programs. J W MinkProg Neurobiol19969004351No
159029971498.574.3537.2Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Robert Visse, Hideaki NagaseCirc Res200312730128No
159129971498.565.2732.6Signaling to NF-kappaB. Matthew S Hayden, Sankar GhoshGenes Dev200415371334No
159214981498.030.7730.8The ubiquitin-proteasome proteolytic pathway. A CiechanoverCell19947923371No
159359921498.0291.2772.8jModelTest 2: more models, new heuristics and parallel computing. Diego Darriba, Guillermo L Taboada, Ramón Doallo, David PosadaNat Methods201222847109Yes
159414971497.00.00.0Synaptic density in human frontal cortex - developmental changes and effects of aging. P R HuttenlocherBrain Res1979427544Yes
159559881497.00.00.0The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. S P Baker, B O'Neill, W Haddon, W B LongJ Trauma19744814394Yes
159614961496.056.3856.4The linear-quadratic formula and progress in fractionated radiotherapy. J F FowlerBr J Radiol19892670032No
159714961496.031.0831.1Network motifs: theory and experimental approaches. Uri AlonNat Rev Genet200717510665No
159874711494.2198.839.8Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan HsuN Engl J Med200415385656Yes
159914941494.00.00.0Dopamine (3-hydroxytyramine) and brain function. O HornykiewiczPharmacol Rev19665328389No
160014941494.044.4144.4Molecular dissection of reactive astrogliosis and glial scar formation. Michael V SofroniewTrends Neurosci200919782411No
160114931493.033.6433.6Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. G L SemenzaAnnu Rev Cell Dev Biol199910611972No
160214931493.030.4530.4The microRNA Registry. Sam Griffiths-JonesNucleic Acids Res200414681370Yes
160314931493.037.0837.1The retinal pigment epithelium in visual function. Olaf StraussPhysiol Rev200515987797No
160414931493.046.3846.4Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Ralph A DefronzoDiabetes200919336687No
160529851492.567.2933.6Why do cancers have high aerobic glycolysis? Robert A Gatenby, Robert J GilliesNat Rev Cancer200415516961No
160629841492.093.9247.0Autophagy: renovation of cells and tissues. Noboru Mizushima, Masaaki KomatsuCell201122078875No
160789511491.8281.0146.8Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939837Yes
160814911491.039.4239.4The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. A S FauciScience19883277274No
160914901490.00.00.0Bias in analytic research. D L SackettJ Chronic Dis1979447779Yes
161014901490.044.2444.2Trail Making Test A and B: normative data stratified by age and education. Tom N TombaughArch Clin Neuropsychol200415010086Yes
161129791489.574.2137.1The DNA-damage response in human biology and disease. Stephen P Jackson, Jiri BartekNature200919847258No
161214891489.038.3138.3The corticosteroid receptor hypothesis of depression. F HolsboerNeuropsychopharmacology200011027914No
161314891489.035.3935.4Hypertrophic cardiomyopathy: a systematic review. Barry J MaronJAMA200211886323No
161414881488.050.6650.7A new automated colorimetric method for measuring total oxidant status. Ozcan ErelClin Biochem200516214125Yes
161514881488.038.6138.6Growth of the plant cell wall. Daniel J CosgroveNat Rev Mol Cell Biol200516261190No
161629751487.50.00.0Lactic dehydrogenase activity in blood. F Wroblewski, J S LadueProc Soc Exp Biol Med195513273400Yes
161714871487.00.00.0Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J C UnkelessJ Exp Med197990108Yes
161829741487.075.8837.9The BCL-2 protein family: opposing activities that mediate cell death. Richard J Youle, Andreas StrasserNat Rev Mol Cell Biol200818097445No
161914861486.00.00.0A soluble protein characteristic of the nervous system. B W MooreBiochem Biophys Res Commun19654953930Yes
162014861486.00.00.0Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. S AvrameasImmunochemistry19694975324Yes
162144551485.095.3831.8The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. S K Hanks, A M Quinn, T HunterScience19883291115No
162229691484.569.4434.7Fibroblasts in cancer. Raghu Kalluri, Michael ZeisbergNat Rev Cancer200616572188No
162314841484.036.6836.7Recognition of errors in three-dimensional structures of proteins. M J SipplProteins19938108378Yes
162414831483.036.7136.7A revolution in optical manipulation. David G GrierNature200312917694No
162544461482.089.7729.9Efficient selection for high-expression transfectants with a novel eukaryotic vector. H Niwa, K Yamamura, J MiyazakiGene19911660837Yes
162629631481.572.9136.5Human mesenchymal stem cells modulate allogeneic immune cell responses. Sudeepta Aggarwal, Mark F PittengerBlood200515494428Yes
162714811481.052.0852.1Lyme disease. A C SteereN Engl J Med19892668764No
162814811481.00.00.0The recurrence of intracranial meningiomas after surgical treatment. D SimpsonJ Neurol Neurosurg Psychiatry195713406590Yes
162914811481.00.00.0Simple methods for "staining with lead" at high pH in electron microscopy. M J KarnovskyJ Biophys Biochem Cytol196114454024Yes
163074031480.6186.9637.4Development and testing of a general amber force field. Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A CaseJ Comput Chem200415116359Yes
163129601480.082.0441.0Angiogenesis. J Folkman, Y ShingJ Biol Chem19921375931No
163214801480.044.0244.0What we can do and what we cannot do with fMRI. Nikos K LogothetisNature200818548064No
163314791479.00.00.0Application of a Theory of Enzyme Specificity to Protein Synthesis. D E KoshlandProc Natl Acad Sci U S A195816590179Yes
163414781478.00.00.0Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. C S NeerJ Bone Joint Surg Am19725054450Yes
163514771477.033.6333.6Tumor suppressor genes. R A WeinbergScience19911659741No
163614771477.00.00.0The colorimetric determination of phosphorus. E J KingBiochem J193216744823Yes
163759021475.5293.3173.3The Satisfaction With Life Scale. E Diener, R A Emmons, R J Larsen, S GriffinJ Pers Assess198516367493Yes
163814751475.039.9339.9Rheumatoid arthritis. Pathophysiology and implications for therapy. E D HarrisN Engl J Med19902271017No
163929501475.059.2729.6Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. P J Mitchell, R TjianScience19892667136No
164029501475.00.00.0The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. E G Gray, V P WhittakerJ Anat196213901297Yes
164144231474.3154.4151.5A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. J R Le Gall, S Lemeshow, F SaulnierJAMA19938254858Yes
164229471473.562.331.1Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Gary L Johnson, Razvan LapadatScience200212471242No
164314731473.00.00.0Simple memory: a theory for archicortex. D MarrPhilos Trans R Soc Lond B Biol Sci19714399412Yes
164444181472.7117.139.0Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Prateek Kumar, Steven Henikoff, Pauline C NgNat Protoc200919561590Yes
164514721472.041.3541.4Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. A FabiatoAm J Physiol19836346892No
1646161911471.9440.3340.0PLINK: a tool set for whole-genome association and population-based linkage analyses. Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C ShamAm J Hum Genet200717701901Yes
164714711471.00.00.0Atherogenesis: a postprandial phenomenon. D B ZilversmitCirculation1979222498Yes
164814711471.00.00.0Isolated removal of hypothalamic or other brain nuclei of the rat. M PalkovitsBrain Res19734747772Yes
164914711471.00.00.0Cognitive maps in rats and men. E C TolmanPsychol Rev194818870876Yes
165029391469.50.00.0Junctional complexes in various epithelia. M G Farquhar, G E PaladeJ Cell Biol196313944428Yes
165114691469.00.00.0Cerebral blood flow and oxygen consumption in man. N A LassenPhysiol Rev195913645234Yes
165214681468.035.5635.6Introduction to NF-kappaB: players, pathways, perspectives. T D GilmoreOncogene200617072321No
165373351467.0168.9733.8Stages of embryonic development of the zebrafish. C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F SchillingDev Dyn19958589427Yes
165414661466.038.1738.2Tricine-SDS-PAGE. Hermann SchäggerNat Protoc200617406207Yes
165514661466.046.1646.2Gold-catalyzed organic reactions. A Stephen K HashmiChem Rev200717580975Yes
165614651465.049.2849.3Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. H J GundersenJ Microsc19863761363Yes
165714651465.047.047.0Constructions of masculinity and their influence on men's well-being: a theory of gender and health. W H CourtenaySoc Sci Med200010741575No
165814641464.039.3839.4Precision mapping of quantitative trait loci. Z B ZengGenetics19948013918Yes
165914641464.035.835.8The hippo signaling pathway in development and cancer. Duojia PanDev Cell201020951342No
166029271463.50.00.0A general method for isolation of high molecular weight DNA from eukaryotes. N Blin, D W StaffordNucleic Acids Res1976987581Yes
166129251462.50.00.0A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. A H Anton, D F SayreJ Pharmacol Exp Ther196214013351Yes
166214621462.031.7831.8DNA in a material world. Nadrian C SeemanNature200312540916No
166343851461.70.00.0The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. J T Dodge, C Mitchell, D J HanahanArch Biochem Biophys196314028302Yes
166443821460.789.2229.7T-Coffee: A novel method for fast and accurate multiple sequence alignment. C Notredame, D G Higgins, J HeringaJ Mol Biol200010964570Yes
166529211460.599.1249.6Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Stephen M Smith, Thomas E NicholsNeuroimage200918501637Yes
166629211460.5111.5355.8Shifting the genomic gold standard for the prokaryotic species definition. Michael Richter, Ramon Rosselló-MóraProc Natl Acad Sci U S A200919855009Yes
166714601460.033.6233.6Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. M B LuskinNeuron19938338665Yes
166843781459.3150.8950.3Phylogenetic identification and in situ detection of individual microbial cells without cultivation. R I Amann, W Ludwig, K H SchleiferMicrobiol Rev19957535888No
166929181459.065.7932.9Cell migration: a physically integrated molecular process. D A Lauffenburger, A F HorwitzCell19968608589No
167014591459.025.2925.3Neuronal specification in the spinal cord: inductive signals and transcriptional codes. T M JessellNat Rev Genet200011262869No
167143751458.384.4428.1Notch signaling: cell fate control and signal integration in development. S Artavanis-Tsakonas, M D Rand, R J LakeScience199910221902No
167214571457.00.00.0Selforganization of matter and the evolution of biological macromolecules. M EigenNaturwissenschaften19714942363No
167314571457.035.0135.0A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. D A GewirtzBiochem Pharmacol199910075079No
167414571457.031.6231.6Oxidative stress shortens telomeres. Thomas von ZglinickiTrends Biochem Sci200212114022Yes
167529141457.095.4247.7Alzheimer's disease. Henry W Querfurth, Frank M LaFerlaN Engl J Med201020107219No
167658261456.50.00.0A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. M A Markwell, S M Haas, L L Bieber, N E TolbertAnal Biochem197898070Yes
167714561456.00.00.0Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. R W SperryProc Natl Acad Sci U S A196314077501Yes
167814561456.034.7634.8Perceptions of epigenetics. Adrian BirdNature200717522671Yes
167929121456.072.6336.3Shared principles in NF-kappaB signaling. Matthew S Hayden, Sankar GhoshCell200818267068No
168072791455.80.00.0Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. S Katz, A B Ford, R W Moskowitz, B A Jackson, M W JaffeJAMA196314044222Yes
168114551455.031.3931.4Neurotrophins and their receptors: a convergence point for many signalling pathways. Moses V ChaoNat Rev Neurosci200312671646No
168229081454.068.3734.2Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. C Auffray, F RougeonEur J Biochem19806772444Yes
168314541454.040.7540.8Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. J A BeavoPhysiol Rev19957480160No
168429081454.097.8648.9Molecular mechanisms and clinical applications of angiogenesis. Peter Carmeliet, Rakesh K JainNature201121593862No
168543611453.7118.6939.6A neural substrate of prediction and reward. W Schultz, P Dayan, P R MontagueScience19979054347No
168614531453.029.029.0Intrinsically unstructured proteins. Peter TompaTrends Biochem Sci200212368089No
168714521452.039.4439.4Redox signaling: nitrosylation and related target interactions of nitric oxide. J S StamlerCell19947923362No
168814521452.035.7735.8Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). K M FoxLancet200313678872Yes
168914521452.00.00.0Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. P C NowellCancer Res196014427849Yes
169014521452.00.00.0Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. I E BushBiochem J195214915960Yes
169143541451.30.00.0Hydroperoxide metabolism in mammalian organs. B Chance, H Sies, A BoverisPhysiol Rev197937532Yes
169214511451.00.00.0The mechanism of muscular contraction. H E HuxleyScience19694181952No
169314501450.00.00.0Defective repair replication of DNA in xeroderma pigmentosum. J E CleaverNature19685655953Yes
169429001450.066.9533.5Complex networks orchestrate epithelial-mesenchymal transitions. Jean Paul Thiery, Jonathan P SleemanNat Rev Mol Cell Biol200616493418No
169528991449.583.6241.8Diarrheagenic Escherichia coli. J P Nataro, J B KaperClin Microbiol Rev19989457432No
169628981449.00.00.0Diabetes and cardiovascular disease. The Framingham study. W B Kannel, D L McGeeJAMA1979430798Yes
169714491449.00.00.0Ionic blockage of sodium channels in nerve. A M WoodhullJ Gen Physiol19734541078Yes
169814491449.00.00.0The organization of proteins in the human red blood cell membrane. A review. T L SteckJ Cell Biol19744600883No
169914491449.00.00.0Starch gel electrophoresis in a discontinous system of buffers. M D PoulikNature195713493570Yes
170014491449.00.00.0Impulses and Physiological States in Theoretical Models of Nerve Membrane. R FitzhughBiophys J196119431309Yes
170186921448.7287.1647.9Cancer statistics, 2009. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J ThunCA Cancer J Clin200919474385Yes
170214481448.032.0732.1From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. W A CatterallNeuron200010798388No
170328961448.00.00.0Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. D H Clarke, J CasalsAm J Trop Med Hyg195813571577Yes
170414471447.031.631.6Drug discovery: a historical perspective. J DrewsScience200010720314No
170514471447.00.00.0The free amino groups of insulin. F SangerBiochem J194516747948Yes
170614451445.043.0243.0Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. M D MainesFASEB J19883290025No
170728901445.076.7938.4The expanding universe of T-cell subsets: Th1, Th2 and more. T R Mosmann, S SadImmunol Today19968820272No
170814451445.042.142.1Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. P A BradfordClin Microbiol Rev200111585791No
170928901445.0105.552.8Palladium-catalyzed ligand-directed C-H functionalization reactions. Thomas W Lyons, Melanie S SanfordChem Rev201020078038No
171057781444.50.00.0The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. L A Sternberger, P H Hardy, J J Cuculis, H G MeyerJ Histochem Cytochem19704192899Yes
171114441444.046.1946.2Evidence for a central component of post-injury pain hypersensitivity. C J WoolfNature19836656869Yes
171214431443.048.548.5Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. G A McPhersonJ Pharmacol Methods19853840547Yes
171314431443.037.737.7Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Shitij KapurAm J Psychiatry200312505794No
171428851442.580.1240.1A rapid boiling method for the preparation of bacterial plasmids. D S Holmes, M QuigleyAnal Biochem19816269464Yes
171514421442.00.00.0Stimulated acoustic emissions from within the human auditory system. D T KempJ Acoust Soc Am1978744838Yes
171614421442.028.9428.9Protein kinases--the major drug targets of the twenty-first century? Philip CohenNat Rev Drug Discov200212120282No
171714421442.00.00.0Nutrition needs of mammalian cells in tissue culture. H EagleScience195513255879Yes
171814421442.029.0129.0Protein degradation and protection against misfolded or damaged proteins. Alfred L GoldbergNature200314685250No
171914411441.00.00.0Superoxide dismutases. I FridovichAnnu Rev Biochem19751094908No
172043231441.0121.2440.4Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. M Hasegawa, H Kishino, T YanoJ Mol Evol19853934395Yes
172128801440.0112.4156.2The mini-mental state examination: a comprehensive review. T N Tombaugh, N J McIntyreJ Am Geriatr Soc19921512391No
172243201440.0113.0637.7The rapid generation of mutation data matrices from protein sequences. D T Jones, W R Taylor, J M ThorntonComput Appl Biosci19921633570Yes
172328791439.50.00.03' non-coding region sequences in eukaryotic messenger RNA. N J Proudfoot, G G BrownleeNature1976822353Yes
172428791439.5106.5253.3The transtheoretical model of health behavior change. J O Prochaska, W F VelicerAm J Health Promot199710170434No
172528781439.059.6429.8NF-kappaB regulation in the immune system. Qiutang Li, Inder M VermaNat Rev Immunol200212360211No
172628771438.50.00.0Mutants of Escherichia coli requiring methionine or vitamin B12. B D Davis, E S MingioliJ Bacteriol195015436457Yes
1727143781437.8358.0235.8Multilineage potential of adult human mesenchymal stem cells. M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R MarshakScience199910102814Yes
172857491437.2234.9558.716S ribosomal DNA amplification for phylogenetic study. W G Weisburg, S M Barns, D A Pelletier, D J LaneJ Bacteriol19911987160Yes
172914371437.074.4374.4Statistics corner: A guide to appropriate use of correlation coefficient in medical research. M M MukakaMalawi Med J201223638278Yes
173028731436.50.00.0Assay of proteins in the presence of interfering materials. A Bensadoun, D WeinsteinAnal Biochem19761259145Yes
173114361436.00.00.0Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. H E HuxleyJ Mol Biol196314064165Yes
173214351435.037.137.1Type I diabetes mellitus. A chronic autoimmune disease. G S EisenbarthN Engl J Med19863517648No
173328691434.555.8227.9The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Michael H Glickman, Aaron CiechanoverPhysiol Rev200211917093No
173414341434.037.6237.6Capacitative calcium entry revisited. J W PutneyCell Calcium19901965707No
173514341434.034.1634.2Binary Agrobacterium vectors for plant transformation. M BevanNucleic Acids Res19846095209Yes
173628661433.075.0137.5Empirical threshold values for quantitative trait mapping. G A Churchill, R W DoergeGenetics19947851788Yes
173728611430.560.9730.5Toll-like receptor control of the adaptive immune responses. Akiko Iwasaki, Ruslan MedzhitovNat Immunol200415454922No
1738128721430.2402.7844.8The 1982 revised criteria for the classification of systemic lupus erythematosus. E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J WinchesterArthritis Rheum19827138600Yes
173914301430.032.5532.5An approximately unbiased test of phylogenetic tree selection. Hidetoshi ShimodairaSyst Biol200212079646Yes
174014301430.029.4929.5Immunosuppressive networks in the tumour environment and their therapeutic relevance. Weiping ZouNat Rev Cancer200515776005No
174128591429.557.1728.6Missing pieces in the NF-kappaB puzzle. Sankar Ghosh, Michael KarinCell200211983155No
174214291429.00.00.0Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. J W OlneyScience19695778021Yes
174328571428.572.6736.3Adipose tissue as an endocrine organ. Erin E Kershaw, Jeffrey S FlierJ Clin Endocrinol Metab200415181022No
174457131428.2118.7929.7A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. B M Bolstad, R A Irizarry, M Astrand, T P SpeedBioinformatics200312538238Yes
174514281428.00.00.0The Gingival Index, the Plaque Index and the Retention Index Systems. H LöeJ Periodontol19675237684Yes
174614281428.051.8851.9Dual-task interference in simple tasks: data and theory. H PashlerPsychol Bull19947972591No
174714271427.025.8825.9Histone acetylation and transcriptional regulatory mechanisms. K StruhlGenes Dev19989499396No
174814271427.035.535.5In vivo near-infrared fluorescence imaging. John V FrangioniCurr Opin Chem Biol200314580568No
174928531426.576.0138.0Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. M A Nitsche, W PaulusJ Physiol200010990547Yes
175014261426.033.9634.0Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. S C ManolagasEndocr Rev200010782361No
175128511425.582.8941.4Dali server: conservation mapping in 3D. Liisa Holm, Päivi RosenströmNucleic Acids Res201020457744Yes
175214251425.00.00.0A clinical method for assessing the ventilatory response to carbon dioxide. D J ReadAustralas Ann Med19676032026Yes
175314251425.045.5245.5Polycystic ovary syndrome. S FranksN Engl J Med19957651477No
175428501425.055.6427.8Cellular motility driven by assembly and disassembly of actin filaments. Thomas D Pollard, Gary G BorisyCell200312600310No
175514241424.033.7633.8PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. Michael F. ThomashowAnnu Rev Plant Physiol Plant Mol Biol199915012220Yes
175614231423.00.00.0Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. M P BlausteinAm J Physiol1977324293No
175714231423.033.733.7Developmental cell death: morphological diversity and multiple mechanisms. P G ClarkeAnat Embryol (Berl)19902186664No
175828461423.069.3934.7The incidence of congenital heart disease. Julien I E Hoffman, Samuel KaplanJ Am Coll Cardiol200212084585No
175942661422.0106.7635.6Two-photon laser scanning fluorescence microscopy. W Denk, J H Strickler, W W WebbScience19902321027Yes
176014221422.00.00.0A modified ninhydrin colorimetric analysis for amino acids. H RosenArch Biochem Biophys195713412116Yes
176114211421.033.7133.7Pathogenesis of group A streptococcal infections. M W CunninghamClin Microbiol Rev200010885988No
176228411420.582.0341.0Multiple sclerosis. Alastair Compston, Alasdair ColesLancet200818970977Yes
176314201420.078.1378.1Subjective well-being. E DienerPsychol Bull19846399758No
176428401420.054.2127.1Mutations affecting segment number and polarity in Drosophila. C Nüsslein-Volhard, E WieschausNature19806776413Yes
176528401420.084.9442.5The precuneus: a review of its functional anatomy and behavioural correlates. Andrea E Cavanna, Michael R TrimbleBrain200616399806No
176628391419.562.6531.3Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. E Krissinel, K HenrickActa Crystallogr D Biol Crystallogr200415572779Yes
176728381419.068.0234.0The human plasma proteome: history, character, and diagnostic prospects. N Leigh Anderson, Norman G AndersonMol Cell Proteomics200212488461No
176856731418.2128.9332.2MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi MiyataNucleic Acids Res200212136088Yes
176914181418.00.00.0Amino acid difference formula to help explain protein evolution. R GranthamScience19744843792Yes
177014181418.046.0646.1The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. G R BuettnerArch Biochem Biophys19938434935No
177114181418.030.3330.3Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. R K JainNat Med200111533692No
177228361418.060.0630.0The Bcl2 family: regulators of the cellular life-or-death switch. Suzanne Cory, Jerry M AdamsNat Rev Cancer200212209154No
177342511417.00.00.0Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. C A Winter, E A Risley, G W NussProc Soc Exp Biol Med196214001233Yes
177428331416.561.930.9The Ki-67 protein: from the known and the unknown. T Scholzen, J GerdesJ Cell Physiol200010653597No
177514161416.035.335.3General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. R A HoughtenProc Natl Acad Sci U S A19852410914Yes
177614161416.036.736.7The biology of incretin hormones. Daniel J DruckerCell Metab200616517403No
177714161416.051.8151.8Cognitive reserve. Yaakov SternNeuropsychologia200919467352No
177828301415.059.4629.7Chemokines: a new classification system and their role in immunity. A Zlotnik, O YoshieImmunity200010714678No
177914151415.032.9533.0Mechanisms of bone metastasis. G David RoodmanN Engl J Med200415084698No
178014151415.030.2430.2Regulatory T cells, tumour immunity and immunotherapy. Weiping ZouNat Rev Immunol200616557261No
178114131413.032.6232.6The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. M TakeichiDevelopment19883048970No
178214131413.034.0134.0PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. B M SpiegelmanDiabetes19989568680No
178314131413.027.2327.2Aggresomes, inclusion bodies and protein aggregation. R R KopitoTrends Cell Biol200011121744No
178414131413.00.00.0Modality and topographic properties of single neurons of cat's somatic sensory cortex. V B MountcastleJ Neurophysiol195713439410Yes
178556481412.0144.6736.2Improved optimization for the robust and accurate linear registration and motion correction of brain images. Mark Jenkinson, Peter Bannister, Michael Brady, Stephen SmithNeuroimage200212377157Yes
178614121412.00.00.0Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. W C SchneiderJ Biol Chem194818886166Yes
178714121412.061.5561.5Antibiotics in the aquatic environment--a review--part I. Klaus KümmererChemosphere200919185900No
178814121412.056.1256.1Large-scale brain networks and psychopathology: a unifying triple network model. Vinod MenonTrends Cogn Sci201121908230No
178914111411.039.6339.6Pathogen recognition and inflammatory signaling in innate immune defenses. Trine H MogensenClin Microbiol Rev200919366914No
179028211410.50.00.0Microdetermination of long-chain fatty acids in plasma and tissues. V P Dole, H MeinertzJ Biol Chem196013817286Yes
179128201410.063.8131.9Raster3D Version 2.0. A program for photorealistic molecular graphics. E A Merritt, M E MurphyActa Crystallogr D Biol Crystallogr199415299354Yes
179214091409.028.728.7Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. D I SvergunBiophys J199910354416Yes
179314091409.036.1636.2Insulin and insulin-like growth factor signalling in neoplasia. Michael PollakNat Rev Cancer200819029956No
179414091409.057.0257.0Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. Virginia A MoyerAnn Intern Med201222801674No
179514081408.059.2559.2Responses to depression and their effects on the duration of depressive episodes. S Nolen-HoeksemaJ Abnorm Psychol19911757671No
179614081408.052.0752.1The case-crossover design: a method for studying transient effects on the risk of acute events. M MaclureAm J Epidemiol19911985444Yes
179714081408.00.00.0The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. O V BatsonAnn Surg194017857618Yes
179828111405.566.0233.0A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. L Buck, R AxelCell19911840504Yes
179928081404.066.5333.3The MAPK signaling cascade. R Seger, E G KrebsFASEB J19957601337No
180028071403.584.1142.1An information-maximization approach to blind separation and blind deconvolution. A J Bell, T J SejnowskiNeural Comput19957584893Yes
180156131403.2244.8661.2An inventory for measuring clinical anxiety: psychometric properties. A T Beck, N Epstein, G Brown, R A SteerJ Consult Clin Psychol19883204199Yes
180214031403.034.5834.6Neurovascular regulation in the normal brain and in Alzheimer's disease. Costantino IadecolaNat Rev Neurosci200415100718No
180314031403.051.1351.1Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Berislav V ZlokovicNat Rev Neurosci201122048062No
180414011401.044.0744.1Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. L BravoNutr Rev19989838798No
180528021401.065.2432.6How matrix metalloproteinases regulate cell behavior. M D Sternlicht, Z WerbAnnu Rev Cell Dev Biol200111687497No
180656001400.0165.7541.4Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. B Biswal, F Z Yetkin, V M Haughton, J S HydeMagn Reson Med19958524021Yes
180770001400.0147.8929.6Prospective identification of tumorigenic breast cancer cells. Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F ClarkeProc Natl Acad Sci U S A200312629218Yes
180827991399.586.5443.3Unified approach for molecular dynamics and density-functional theory. Car, ParrinelloPhys Rev Lett198510032153Yes
180913991399.065.4865.5The structure and properties of the sense of coherence scale. A AntonovskySoc Sci Med19938480217Yes
181055931398.20.00.0A rating scale for mania: reliability, validity and sensitivity. R C Young, J T Biggs, V E Ziegler, D A MeyerBr J Psychiatry1978728692Yes
181113981398.00.00.0R factor transfer in Rhizobium leguminosarum. J E BeringerJ Gen Microbiol19744612098Yes
181213981398.047.047.0Validation of a decisional conflict scale. A M O'ConnorMed Decis Making19957898294Yes
181341941398.092.9331.0NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. S Ghosh, M J May, E B KoppAnnu Rev Immunol19989597130No
181413981398.036.5636.6Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. B Winkel-ShirleyPlant Physiol200111402179No
181527961398.00.00.0Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. H J Bloom, W W RichardsonBr J Cancer195713499785Yes
181613971397.050.0750.1Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Joseph J VolpeLancet Neurol200919081519No
181727921396.085.5142.8The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. J D Hayes, D J PulfordCrit Rev Biochem Mol Biol19958770536No
181813961396.00.00.0Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. J WymanAdv Protein Chem196414268785No
181927901395.00.00.0Empirical predictions of protein conformation. P Y Chou, G D FasmanAnnu Rev Biochem1978354496No
182013941394.052.0652.1Falls in older people: epidemiology, risk factors and strategies for prevention. Laurence Z RubensteinAge Ageing200616926202No
182127841392.073.0836.5Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. I Issemann, S GreenNature19902129546Yes
182227841392.085.8742.9Intracellular pH. A Roos, W F BoronPhysiol Rev19817012859No
182313911391.00.00.0Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. K S McCullyAm J Pathol19695792556Yes
182413911391.034.6434.6The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. H MaedaAdv Enzyme Regul200111384745No
182527801390.00.00.0Brain stem reticular formation and activation of the EEG. G Moruzzi, H W MagounElectroencephalogr Clin Neurophysiol194918421835Yes
182669461389.2151.2130.2Site-directed mutagenesis by overlap extension using the polymerase chain reaction. S N Ho, H D Hunt, R M Horton, J K Pullen, L R PeaseGene19892744487Yes
182727751387.50.00.0A method of trace iodination of proteins for immunologic studies. P J McConahey, F J DixonInt Arch Allergy Appl Immunol19664160044Yes
182813871387.00.00.0The genetical evolution of social behaviour. II. W D HamiltonJ Theor Biol19645875340Yes
182927721386.071.9236.0A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. J Messing, J VieiraGene19826295880Yes
183013861386.039.9840.0Isolation and cultivation of Lyme disease spirochetes. A G BarbourYale J Biol Med19846393604Yes
183113861386.033.1133.1Functions of ceramide in coordinating cellular responses to stress. Y A HannunScience19968943189No
183241561385.3121.0940.4The fusiform face area: a module in human extrastriate cortex specialized for face perception. N Kanwisher, J McDermott, M M ChunJ Neurosci19979151747Yes
183313851385.00.00.0Statistical analysis of enzyme kinetic data. W W ClelandMethods Enzymol1979502857Yes
183413851385.032.6832.7Speculations on the functions of the major heat shock and glucose-regulated proteins. H R PelhamCell19862944601Yes
183513841384.00.00.0Human cardiovascular adjustments to exercise and thermal stress. L B RowellPhysiol Rev19744587247No
183613841384.036.7336.7Aspergillus fumigatus and aspergillosis. J P LatgéClin Microbiol Rev199910194462No
183713831383.00.00.0The measurement of psychological androgyny. S L BemJ Consult Clin Psychol19744823550Yes
183813831383.027.3627.4Vienna RNA secondary structure server. Ivo L HofackerNucleic Acids Res200312824340Yes
183913831383.00.00.0Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. K FuxeActa Physiol Scand Suppl196514319769Yes
184013831383.033.2333.2Far-field optical nanoscopy. Stefan W HellScience200717525330No
184127641382.00.00.0A protein sequenator. P Edman, G BeggEur J Biochem19676059350Yes
184241451381.7141.8547.3Vascular endothelial cells synthesize nitric oxide from L-arginine. R M Palmer, D S Ashton, S MoncadaNature19883131684Yes
184327631381.50.00.0A scaled version of the General Health Questionnaire. D P Goldberg, V F HillierPsychol Med1979424481Yes
184427631381.592.2646.1The efficiency of systematic sampling in stereology and its prediction. H J Gundersen, E B JensenJ Microsc19873430576Yes
184513811381.00.00.0Selection of successive tumour lines for metastasis. I J FidlerNat New Biol19734512654Yes
184627621381.062.3931.2An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. A A Beg, D BaltimoreScience19968864118Yes
184755231380.8126.4831.6Probability-based protein identification by searching sequence databases using mass spectrometry data. D N Perkins, D J Pappin, D M Creasy, J S CottrellElectrophoresis199910612281Yes
184813801380.00.00.0Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. C A BarnesJ Comp Physiol Psychol1979221551Yes
184913801380.072.6772.7Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. F E ZajacCrit Rev Biomed Eng19892676342No
185027591379.559.7429.9Development by self-digestion: molecular mechanisms and biological functions of autophagy. Beth Levine, Daniel J KlionskyDev Cell200415068787No
185113791379.031.0731.1Protein misfolding, evolution and disease. C M DobsonTrends Biochem Sci199910470028No
185227581379.0100.9950.5Neurocircuitry of addiction. George F Koob, Nora D VolkowNeuropsychopharmacology201019710631No
185313781378.032.6732.7The molecular logic of endocannabinoid signalling. Daniele PiomelliNat Rev Neurosci200314595399No
185413781378.040.940.9n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Philip C CalderAm J Clin Nutr200616841861No
185527551377.588.7744.4Functional architecture of basal ganglia circuits: neural substrates of parallel processing. G E Alexander, M D CrutcherTrends Neurosci19901695401No
185641321377.3109.0136.3Optimization by simulated annealing. S Kirkpatrick, C D Gelatt, M P VecchiScience198317813860Yes
185727541377.067.7533.9Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. F Q Schafer, G R BuettnerFree Radic Biol Med200111368918No
185827531376.570.6235.3CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. D G Higgins, P M SharpGene19883243435Yes
185927531376.570.5135.3Steatohepatitis: a tale of two "hits"? C P Day, O F JamesGastroenterology19989547102No
186027521376.092.046.0Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. G R Gibson, M B RoberfroidJ Nutr19957782892No
186113751375.043.543.5Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. James J P StewartJ Mol Model200717828561Yes
186227491374.563.4831.7Microtubules as a target for anticancer drugs. Mary Ann Jordan, Leslie WilsonNat Rev Cancer200415057285No
186313741374.00.00.0An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. O SmithiesBiochem J195913638269Yes
186413741374.038.0538.0External validity of randomised controlled trials: "to whom do the results of this trial apply?". Peter M RothwellLancet200515639683Yes
186527471373.562.5531.3Neurotrophins: roles in neuronal development and function. E J Huang, L F ReichardtAnnu Rev Neurosci200111520916No
186627461373.00.00.0Prediction of protein conformation. P Y Chou, G D FasmanBiochemistry19744358940Yes
186713731373.030.1830.2Neurotrophins as synaptic modulators. M M PooNat Rev Neurosci200111253356No
186827451372.5102.3551.2Pain assessment: global use of the Brief Pain Inventory. C S Cleeland, K M RyanAnn Acad Med Singap19948080219No
186927451372.559.7229.9Coordination of circadian timing in mammals. Steven M Reppert, David R WeaverNature200212198538No
187013721372.026.4426.4Ubiquitin-dependent protein degradation. M HochstrasserAnnu Rev Genet19968982460No
187113721372.032.232.2The NCI60 human tumour cell line anticancer drug screen. Robert H ShoemakerNat Rev Cancer200616990858No
187227441372.00.00.0Mutations of Bacteria from Virus Sensitivity to Virus Resistance. S E Luria, M DelbrückGenetics194317247100Yes
187313721372.00.00.0Note on the sampling error of the difference between correlated proportions or percentages. Q McNEMARPsychometrika194720254758Yes
187413711371.00.00.0Effects of varying the vehicle for OsO4 in tissue fixation. J B CaulfieldJ Biophys Biochem Cytol195713475399Yes
1875123391371.0461.2451.2STAR: ultrafast universal RNA-seq aligner. Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R GingerasBioinformatics201323104886Yes
187613701370.043.9544.0Systemic lupus erythematosus. George C TsokosN Engl J Med201122129255No
187727391369.50.00.0Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. A J Berk, P A SharpCell1977922889Yes
187827391369.50.00.0The effect of sodium ions on the electrical activity of giant axon of the squid. A L Hodgkin, B KatzJ Physiol194918128147Yes
187913691369.00.00.0Microbial ecology of the gastrointestinal tract. D C SavageAnnu Rev Microbiol1977334036No
188013691369.092.1792.2The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. F C EwaldClin Orthop Relat Res19892805502Yes
188127381369.057.8528.9Fitting a mixture model by expectation maximization to discover motifs in biopolymers. T L Bailey, C ElkanProc Int Conf Intell Syst Mol Biol19947584402Yes
188213691369.057.8357.8Adverse health effects of high-effort/low-reward conditions. J SiegristJ Occup Health Psychol19969547031No
188327371368.575.8137.9Early identification of refractory epilepsy. P Kwan, M J BrodieN Engl J Med200010660394Yes
188427371368.572.3736.2Malignant gliomas in adults. Patrick Y Wen, Santosh KesariN Engl J Med200818669428No
188513681368.056.6956.7A structured interview guide for the Hamilton Depression Rating Scale. J B WilliamsArch Gen Psychiatry19883395203Yes
188613681368.031.7931.8Protein kinase C: structure, function, and regulation. A C NewtonJ Biol Chem19957499357No
188713681368.033.2833.3The basic science of gene therapy. R C MulliganScience19938493530No
188813681368.029.3329.3Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. S S FergusonPharmacol Rev200111171937No
188913681368.043.5443.5The many roles for fluorine in medicinal chemistry. William K HagmannJ Med Chem200818570365Yes
189013671367.026.526.5NK cell receptors. L L LanierAnnu Rev Immunol19989597134No
189113671367.035.1735.2Myeloperoxidase: friend and foe. Seymour J KlebanoffJ Leukoc Biol200515689384No
189227331366.5100.0450.0Biology of disease: free radicals and tissue injury. B A Freeman, J D CrapoLab Invest19826290784No
189354651366.2161.8240.5Comorbidity measures for use with administrative data. A Elixhauser, C Steiner, D R Harris, R M CoffeyMed Care19989431328Yes
189413661366.045.045.0Social relationships and health. Sheldon CohenAm Psychol200415554821No
189513651365.037.0337.0Cell and environment interactions in tumor microregions: the multicell spheroid model. R M SutherlandScience19882451290Yes
189627301365.053.4226.7T-cell antigen receptor genes and T-cell recognition. M M Davis, P J BjorkmanNature19883043226No
189713651365.035.4535.5Stress and hippocampal plasticity. B S McEwenAnnu Rev Neurosci199910202533No
189827301365.090.1745.1Density functionals with broad applicability in chemistry. Yan Zhao, Donald G TruhlarAcc Chem Res200818186612Yes
189913651365.037.9738.0Integration, scaling, space-group assignment and post-refinement. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124693Yes
190027291364.581.6540.8Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Sally S Dickerson, Margaret E KemenyPsychol Bull200415122924Yes
190127281364.070.3535.2Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. D Marion, K WüthrichBiochem Biophys Res Commun19836307308Yes
190213641364.028.7328.7RNA silencing in plants. David BaulcombeNature200415372043No
190313641364.031.5331.5Cancer epigenomics: DNA methylomes and histone-modification maps. Manel EstellerNat Rev Genet200717339880No
190427251362.582.2241.1Glycine potentiates the NMDA response in cultured mouse brain neurons. J W Johnson, P AscherNature19872433595Yes
190513621362.047.8747.9Multiple calcium channels and neuronal function. R J MillerScience19872432656No
190613621362.00.00.0Codon--anticodon pairing: the wobble hypothesis. F H CrickJ Mol Biol19665969078Yes
190713621362.064.2664.3The emerging role of lncRNAs in cancer. Maite HuarteNat Med201526540387No
190813621362.066.9867.0Gctf: Real-time CTF determination and correction. Kai ZhangJ Struct Biol201626592709Yes
190927231361.584.1542.1Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. P J Basser, C PierpaoliJ Magn Reson B19968661285Yes
191027221361.076.2738.1Transforming growth factor beta in tissue fibrosis. W A Border, N A NobleN Engl J Med19947935686No
191113611361.038.7638.8A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. J EngelEpilepsia200111422340Yes
191213611361.037.8337.8Task switching. Stephen MonsellTrends Cogn Sci200312639695Yes
191327221361.00.00.0Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. A Dahlstroem, K FuxeActa Physiol Scand Suppl196414229500Yes
191427201360.090.0845.0Unidentified curved bacilli on gastric epithelium in active chronic gastritis. J R Warren, B MarshallLancet19836134060Yes
191513601360.039.9540.0Leishmaniasis: current situation and new perspectives. P DesjeuxComp Immunol Microbiol Infect Dis200415225981No
191613601360.00.00.0Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. P F ScholanderJ Biol Chem194720281644Yes
191727191359.50.00.0Immunoassay of endogenous plasma insulin in man. R S Yalow, S A BersonJ Clin Invest196013846364Yes
191813591359.030.5630.6Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. M KozakMicrobiol Rev19836343825No
191913591359.054.354.3Cardiac valve surgery--the "French correction". A CarpentierJ Thorac Cardiovasc Surg19836887954Yes
192013581358.040.6240.6The aging process. D HarmanProc Natl Acad Sci U S A19816947277Yes
192127161358.084.7642.4Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. James J Gross, Oliver P JohnJ Pers Soc Psychol200312916575Yes
192213581358.00.00.0Potential, Impedance, And Rectification In Membranes. D E GoldmanJ Gen Physiol194319873371Yes
192340731357.788.9529.7Toll-like receptors. Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo AkiraAnnu Rev Immunol200312524386No
192427151357.577.9139.0Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. B R Celli, W MacNeeEur Respir J200415219010No
192594981356.9212.5930.4Embryonic stem cell lines derived from human blastocysts. J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M JonesScience19989804556Yes
192613561356.00.00.0Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. T SpectorAnal Biochem1978655375Yes
192713561356.00.00.0Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. S S LehrerBiochemistry19715119250Yes
192813561356.031.5131.5Tumor metastasis: mechanistic insights and clinical challenges. Patricia S SteegNat Med200616892035No
192913561356.034.4234.4Five rules for the evolution of cooperation. Martin A NowakScience200617158317No
193027101355.0168.7284.4Rating systems in the evaluation of knee ligament injuries. Y Tegner, J LysholmClin Orthop Relat Res19854028566Yes
193127101355.00.00.0The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. J O'Keefe, J DostrovskyBrain Res19715124915Yes
193213551355.044.2844.3Efficient analysis of experimental observations. W J DixonAnnu Rev Pharmacol Toxicol19807387124Yes
193340621354.00.00.0Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Garnier, D J Osguthorpe, B RobsonJ Mol Biol1978642007Yes
193427081354.00.00.0Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. R L Heath, L PackerArch Biochem Biophys19685655425Yes
193513541354.034.9234.9An economic method for the fluorescent labeling of PCR fragments. M SchuelkeNat Biotechnol200010657137Yes
193613541354.00.00.0Cerebral vascular accidents in patients over the age of 60. II. Prognosis. J RankinScott Med J195713432835Yes
193727071353.5109.4354.7Assessment of eating disorders: interview or self-report questionnaire? C G Fairburn, S J BeglinInt J Eat Disord19947866415Yes
193827061353.085.9243.0Performing the exact test of Hardy-Weinberg proportion for multiple alleles. S W Guo, E A ThompsonBiometrics19921637966Yes
193927061353.0102.4751.2The need to belong: desire for interpersonal attachments as a fundamental human motivation. R F Baumeister, M R LearyPsychol Bull19957777651No
194027061353.063.7331.9Lipopolysaccharide endotoxins. Christian R H Raetz, Chris WhitfieldAnnu Rev Biochem200212045108No
194113531353.042.6442.6Surface plasmon resonance sensors for detection of chemical and biological species. Jirí HomolaChem Rev200818229953No
194213521352.045.3345.3Interleukin-1. C A DinarelloRev Infect Dis19846369481No
194313521352.032.1532.1Ordered porous materials for emerging applications. Mark E DavisNature200212075343No
194440531351.090.6230.2Telomeres shorten during ageing of human fibroblasts. C B Harley, A B Futcher, C W GreiderNature19902342578Yes
194513511351.062.7862.8Pro-resolving lipid mediators are leads for resolution physiology. Charles N SerhanNature201424899309No
194654031350.8165.6841.4The validity of the Hospital Anxiety and Depression Scale. An updated literature review. Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag NeckelmannJ Psychosom Res200211832252No
194727011350.567.733.9Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. E S Lander, D BotsteinGenetics19892563713Yes
194827011350.580.940.5EQ-5D: a measure of health status from the EuroQol Group. R Rabin, F de CharroAnn Med200111491192No
194926991349.587.1443.6Mechanisms of salinity tolerance. Rana Munns, Mark TesterAnnu Rev Plant Biol200818444910No
195013491349.033.3533.4Neuronal synchrony: a versatile code for the definition of relations? W SingerNeuron199910677026No
195126971348.554.227.1The evolutionary fate and consequences of duplicate genes. M Lynch, J S ConeryScience200011073452No
195226971348.572.8136.4Obesity. David W Haslam, W Philip T JamesLancet200516198769No
195340431347.70.00.0Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. D D Sabatini, K Bensch, R J BarrnettJ Cell Biol196313975866Yes
195426941347.00.00.0The respiratory chain and oxidative phosphorylation. B Chance, G R WilliamsAdv Enzymol Relat Subj Biochem195613313307Yes
195526941347.062.6631.3Cancer metastasis: building a framework. Gaorav P Gupta, Joan MassaguéCell200617110329No
195653841346.00.00.0Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. D W Cleveland, S G Fischer, M W Kirschner, U K LaemmliJ Biol Chem1977320200Yes
195726921346.062.6831.3NF-kappaB: a key role in inflammatory diseases. P P Tak, G S FiresteinJ Clin Invest200111134171No
195813461346.074.6174.6The biology and function of fibroblasts in cancer. Raghu KalluriNat Rev Cancer201627550820No
195940371345.796.6532.2Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Hartmuth C. Kolb, M. G. Finn, K. Barry SharplessAngew Chem Int Ed Engl200111433435Yes
196013451345.043.8143.8Glutathione metabolism and its selective modification. A MeisterJ Biol Chem19883053703No
196113451345.00.00.0Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. J R DavidProc Natl Acad Sci U S A19665229858Yes
196213451345.039.7139.7Glycobiology: Toward Understanding the Function of Sugars. Raymond A. DwekChem Rev199611848770Yes
196313441344.036.3636.4Use and misuse of the receiver operating characteristic curve in risk prediction. Nancy R CookCirculation200717309939Yes
196426871343.566.2633.1Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. H Cai, D G HarrisonCirc Res200011073878No
196513431343.00.00.0A modified procedure for lead staining of thin sections. G MillonigJ Biophys Biochem Cytol196114474176Yes
196613421342.035.1435.1The failing heart--an engine out of fuel. Stefan NeubauerN Engl J Med200717360992No
196726821341.00.00.0Further improvements in the plaque technique for detecting single antibody-forming cells. A J Cunningham, A SzenbergImmunology19685653817Yes
196826821341.0106.9153.5Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. Sarvajeet Singh Gill, Narendra TutejaPlant Physiol Biochem201020870416No
196926811340.555.5727.8Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. P J Southern, P BergJ Mol Appl Genet19826286831Yes
197013401340.043.8843.9Equipoise and the ethics of clinical research. B FreedmanN Engl J Med19873600702Yes
197113401340.00.00.0Blood gas calculator. J W SeveringhausJ Appl Physiol19665912737Yes
197240201340.0141.947.3Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. Aleksandr V Marenich, Christopher J Cramer, Donald G TruhlarJ Phys Chem B200919366259Yes
197340191339.791.2130.4TOR signaling in growth and metabolism. Stephan Wullschleger, Robbie Loewith, Michael N HallCell200616469695No
197426781339.00.00.0Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. E Engvall, P PerlmannJ Immunol19724113792Yes
197513391339.036.4736.5A more meaningful scoring system for determining the severity of coronary heart disease. G G GensiniAm J Cardiol19836823874Yes
197613391339.048.4548.5Colorimetric determination of phospholipids with ammonium ferrothiocyanate. J C StewartAnal Biochem19806892980Yes
197713391339.041.2541.2Semiempirical hybrid density functional with perturbative second-order correlation. Stefan GrimmeJ Chem Phys200616438568Yes
197826771338.5111.7555.9Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. A Y Finlay, G K KhanClin Exp Dermatol19948033378Yes
197926761338.00.00.0Synchronization of Plasmodium falciparum erythrocytic stages in culture. C Lambros, J P VanderbergJ Parasitol1979383936Yes
198013381338.034.6334.6Lead- and drug-like compounds: the rule-of-five revolution. Christopher A LipinskiDrug Discov Today Technol200424981612Yes
198113371337.027.6927.7Macromolecular crowding: obvious but underappreciated. R J EllisTrends Biochem Sci200111590012No
198213371337.00.00.0A simple ultraviolet spectrophotometric method for the determination of protein. W J WaddellJ Lab Clin Med195613346201Yes
198313371337.029.0429.0The Buccaneer software for automated model building. 1. Tracing protein chains. Kevin CowtanActa Crystallogr D Biol Crystallogr200616929101Yes
198426721336.078.0339.0Mortality by cause for eight regions of the world: Global Burden of Disease Study. C J Murray, A D LopezLancet19979142060Yes
198526711335.563.131.6NF-kappa B: ten years after. P A Baeuerle, D BaltimoreCell19968858144No
198626701335.00.00.0Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. G J Miller, N E MillerLancet197546338Yes
198713351335.032.8132.8Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. G von HeijneJ Mol Biol19921593632Yes
198813341334.00.00.0Immunological function of the thymus. J F MillerLancet196114474038Yes
198913341334.031.4331.4Hematopoietic stem-cell transplantation. Edward A CopelanN Engl J Med200616641398No
199079991333.2274.9945.8New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier GascuelSyst Biol201020525638Yes
199126651332.596.4548.2The Oswestry Disability Index. J C Fairbank, P B PynsentSpine (Phila Pa 1976)200011074683No
199226631331.50.00.0Selective loss of central cholinergic neurons in Alzheimer's disease. P Davies, A J MaloneyLancet197663862Yes
199326631331.577.1738.6Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. F D Lublin, S C ReingoldNeurology19968780061Yes
199413311331.034.2934.3Thioredoxin and glutaredoxin systems. A HolmgrenJ Biol Chem19892668278No
199526621331.067.4333.7Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. M D Pierschbacher, E RuoslahtiNature19846325925Yes
199639921330.7100.7633.6Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck ØrntoftCancer Res200415289330Yes
199713301330.045.2545.2Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. N KriegerAm J Public Health19921566949Yes
199813291329.041.5341.5Neurotransmitters and neuromodulators in the basal ganglia. A M GraybielTrends Neurosci19901695398No
199913291329.041.9341.9Domino Reactions in Organic Synthesis. Lutz F. TietzeChem Rev199611848746Yes
200013291329.033.0933.1Oxidative stress in Parkinson's disease. Peter JennerAnn Neurol200312666096No
200126561328.00.00.0Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. E Engvall, P PerlmannImmunochemistry19715135623Yes
200226551327.50.00.0Peptidoglycan types of bacterial cell walls and their taxonomic implications. K H Schleifer, O KandlerBacteriol Rev19724568761No
200313271327.00.00.0Stereological principles for morphometry in electron microscopic cytology. E R WeibelInt Rev Cytol19694899604No
200413271327.032.3632.4Two pathogenetic types of endometrial carcinoma. J V BokhmanGynecol Oncol19836822361Yes
200513271327.025.0825.1The DNA methyltransferases of mammals. T H BestorHum Mol Genet200011005794No
200613271327.035.7335.7Hydrogels for biomedical applications. Allan S HoffmanAdv Drug Deliv Rev200211755703No
200726511325.583.1141.6From best evidence to best practice: effective implementation of change in patients' care. Richard Grol, Jeremy GrimshawLancet200314568747No
200826511325.569.0234.5Unravelling the pathogenesis of inflammatory bowel disease. R J Xavier, D K PodolskyNature200717653185No
200913251325.025.6725.7Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. M G GustafssonJ Microsc200010810003Yes
201013251325.0117.55117.5Minimap2: pairwise alignment for nucleotide sequences. Heng LiBioinformatics201829750242Yes
201139731324.3142.5347.5Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Helga Thorvaldsdóttir, James T Robinson, Jill P MesirovBrief Bioinform201322517427Yes
201213241324.064.9965.0Molecular pathology of schizophrenia: more than one disease process? T J CrowBr Med J19806101544No
201313241324.036.2536.2Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. S L FriedmanN Engl J Med19938502273No
201413241324.034.7334.7The amygdala modulates the consolidation of memories of emotionally arousing experiences. James L McGaughAnnu Rev Neurosci200415217324No
201539711323.7130.8643.6Estimating the mean and variance from the median, range, and the size of a sample. Stela Pudar Hozo, Benjamin Djulbegovic, Iztok HozoBMC Med Res Methodol200515840177Yes
201626471323.50.00.0Immunization of dissociated spleen cell cultures from normal mice. R I Mishell, R W DuttonJ Exp Med19676034749Yes
201726471323.568.7434.4Molecular beacons: probes that fluoresce upon hybridization. S Tyagi, F R KramerNat Biotechnol19969630890Yes
201826461323.094.9547.5A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. C M Tsai, C E FraschAnal Biochem19826176137Yes
201913231323.081.9181.9Deep learning in neural networks: an overview. Jürgen SchmidhuberNeural Netw201525462637No
202026441322.054.6127.3Cancer genes and the pathways they control. Bert Vogelstein, Kenneth W KinzlerNat Med200415286780No
202126441322.056.628.3Intrinsically unstructured proteins and their functions. H Jane Dyson, Peter E WrightNat Rev Mol Cell Biol200515738986No
202239641321.3119.7139.9Regularization Paths for Generalized Linear Models via Coordinate Descent. Jerome Friedman, Trevor Hastie, Rob TibshiraniJ Stat Softw201020808728Yes
202326421321.00.00.0Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. G Blobel, B DobbersteinJ Cell Biol1975811671Yes
202492411320.1459.965.7limma powers differential expression analyses for RNA-sequencing and microarray studies. Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K SmythNucleic Acids Res201525605792Yes
202513201320.00.00.0Origin of concatemeric T7 DNA. J D WatsonNat New Biol19724507727Yes
202613201320.027.2227.2Dimerization of cell surface receptors in signal transduction. C H HeldinCell19957834741No
202713201320.047.0547.0The polyvagal perspective. Stephen W PorgesBiol Psychol200717049418No
202813201320.00.00.0The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. R C LewontinGenetics196417248194Yes
202926381319.00.00.0Virus interference. I. The interferon. A Isaacs, J LindenmannProc R Soc Lond B Biol Sci195713465720Yes
203013191319.00.00.0A quantitative immunochemical measure of the primary interaction between I BSA and antibody. R S FarrJ Infect Dis195813611294Yes
203113181318.00.00.0Renin-angiotensin system: biochemistry and mechanisms of action. M J PeachPhysiol Rev1977191856No
203213181318.033.6433.6The use of nanocrystals in biological detection. Paul AlivisatosNat Biotechnol200414704706Yes
203313171317.047.6547.6Neuropeptide Y: complete amino acid sequence of the brain peptide. K TatemotoProc Natl Acad Sci U S A19826957876Yes
203413171317.00.00.0Cellular resistance to infection. G B MackanessJ Exp Med196214467923Yes
203526331316.560.6330.3Self-assembly at all scales. George M Whitesides, Bartosz GrzybowskiScience200211923529Yes
203652651316.2125.1931.3Quantitative monitoring of gene expression patterns with a complementary DNA microarray. M Schena, D Shalon, R W Davis, P O BrownScience19957569999Yes
203726321316.051.4325.7Oncogenic kinase signalling. P Blume-Jensen, T HunterNature200111357143No
203813161316.032.1832.2Neurotrophin-regulated signalling pathways. Louis F ReichardtPhilos Trans R Soc Lond B Biol Sci200616939974No
203926301315.00.00.0Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. D H Figurski, D R HelinskiProc Natl Acad Sci U S A1979377280Yes
204013141314.026.1626.2Chromosomal translocations in human cancer. T H RabbittsNature19947969446No
2041170811313.9482.637.1Clustal W and Clustal X version 2.0. M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G HigginsBioinformatics200717846036Yes
204213131313.041.8241.8The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. L W SwansonBrain Res Bull19826816390Yes
204313131313.00.00.0The antidiuretic hormone and the factors which determine its release. E B VerneyProc R Soc Lond B Biol Sci194718918876Yes
204426231311.5113.056.5Regulation of microRNA biogenesis. Minju Ha, V Narry KimNat Rev Mol Cell Biol201425027649No
204513111311.00.00.0Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. W W DouglasBr J Pharmacol19684882190No
204626221311.060.7730.4Integrins and signal transduction pathways: the road taken. E A Clark, J S BruggeScience19957716514No
204713111311.036.2836.3The world health report 2002 - reducing risks, promoting healthy life. J J GuilbertEduc Health (Abingdon)200314741909Yes
204813101310.034.6634.7The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. K KuwajimaProteins19892695928No
204913101310.035.435.4Fibronectin and its receptors. E RuoslahtiAnnu Rev Biochem19882972252No
205013101310.00.00.0Agammaglobulinemia. O C BrutonPediatrics195214929630Yes
205126201310.0119.9260.0Deciphering key features in protein structures with the new ENDscript server. Xavier Robert, Patrice GouetNucleic Acids Res201424753421Yes
205252391309.8305.6776.4Prevalence of childhood and adult obesity in the United States, 2011-2012. Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M FlegalJAMA201424570244Yes
205313091309.00.00.0Letter: Grading of angina pectoris. L CampeauCirculation1976947585Yes
205413091309.030.730.7The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. S E KahnDiabetologia200312637977No
205539271309.0174.1158.0Molecular mechanisms of epithelial-mesenchymal transition. Samy Lamouille, Jian Xu, Rik DerynckNat Rev Mol Cell Biol201424556840No
205613091309.088.8988.9The antibiotic resistance crisis: part 1: causes and threats. C Lee VentolaP T201525859123Yes
205713081308.042.9943.0History of the Rochester Epidemiology Project. L J MeltonMayo Clin Proc19968594285No
205826151307.559.9130.0Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. E Y Chen, P H SeeburgDNA19853996185Yes
205926151307.596.5248.3Saliency, switching, attention and control: a network model of insula function. Vinod Menon, Lucina Q UddinBrain Struct Funct201020512370No
206052261306.5142.1335.5Most mammalian mRNAs are conserved targets of microRNAs. Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P BartelGenome Res200918955434Yes
206113061306.044.744.7Gene flow and the geographic structure of natural populations. M SlatkinScience19873576198Yes
206213051305.041.6141.6The phenomenon of the acute phase response. I KushnerAnn N Y Acad Sci19827046585No
206313051305.031.631.6Apoptosis in cancer therapy: crossing the threshold. D E FisherCell19948069905No
206426101305.061.7530.9The pathophysiology and treatment of sepsis. Richard S Hotchkiss, Irene E KarlN Engl J Med200312519925No
206513051305.041.1841.2Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. M Robin DiMatteoMed Care200415076819Yes
206613041304.034.2334.2N-heterocyclic carbenes: a new concept in organometallic catalysis. Wolfgang A HerrmannAngew Chem Int Ed Engl200219750753Yes
206726081304.072.4236.2Macrophage diversity enhances tumor progression and metastasis. Bin-Zhi Qian, Jeffrey W PollardCell201020371344No
206826071303.560.7930.4The RXR heterodimers and orphan receptors. D J Mangelsdorf, R M EvansCell19958521508No
206939101303.398.032.7The p53 tumour suppressor gene. A J Levine, J Momand, C A FinlayNature19912046748No
207013031303.037.2837.3The matrix-degrading metalloproteinases. L M MatrisianBioessays19921445287No
207113031303.043.9944.0Stress signalling pathways that impair prefrontal cortex structure and function. Amy F T ArnstenNat Rev Neurosci200919455173No
207213031303.00.00.0Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. H M KalckarJ Biol Chem194720285041Yes
207326051302.578.3639.2Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. C J Murray, A D LopezLancet19979164317Yes
207413021302.025.9525.9Epithelial-mesenchymal transitions in development and pathologies. Jean Paul ThieryCurr Opin Cell Biol200314644200No
207513011301.00.00.0Electrophoretic separation of plasma lipoproteins in agarose gel. R P NobleJ Lipid Res19684176473Yes
207613011301.028.1628.2Double identity for proteins of the Bcl-2 family. J C ReedNature19979194558No
207713011301.029.5529.6A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Dale R NyholtAm J Hum Genet200414997420Yes
207813001300.064.9765.0What's in a name? Qualitative description revisited. Margarete SandelowskiRes Nurs Health201020014004Yes
207912991299.050.5750.6Free-radical mechanisms in tissue injury. T F SlaterBiochem J19846383353No
208012991299.029.7629.8Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. W D SniderCell19948205613No
208112991299.033.0133.0Tobacco smoke carcinogens and lung cancer. S S HechtJ Natl Cancer Inst199910413421No
208264951299.0291.4858.3UCHIME improves sensitivity and speed of chimera detection. Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob KnightBioinformatics201121700674Yes
208325971298.554.1127.1Wnt signalling in stem cells and cancer. Tannishtha Reya, Hans CleversNature200515829953No
208425971298.577.0738.5Materials for electrochemical capacitors. Patrice Simon, Yury GogotsiNat Mater200818956000Yes
208512971297.030.6830.7Hyaluronan: from extracellular glue to pericellular cue. Bryan P TooleNat Rev Cancer200415229478No
208651871296.8180.0245.0clusterProfiler: an R package for comparing biological themes among gene clusters. Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu HeOMICS201222455463Yes
208738901296.789.9230.0Osteoclast differentiation and activation. William J Boyle, W Scott Simonet, David L LaceyNature200312748652No
208812961296.036.8936.9The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. R G GerrityAm J Pathol19817234961Yes
208912961296.054.2954.3Sample size in qualitative research. M SandelowskiRes Nurs Health19957899572Yes
209025901295.056.528.2The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. M S Brown, J L GoldsteinCell19979150132No
209112951295.027.6227.6Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. R I MorimotoGenes Dev19989869631No
209212951295.043.1643.2The functional gastrointestinal disorders and the Rome III process. Douglas A DrossmanGastroenterology200616678553No
209312951295.050.3750.4Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. Peter C AustinPharm Stat201120925139Yes
209412941294.031.4731.5Regulation of differentiation of vascular smooth muscle cells. G K OwensPhysiol Rev19957624392No
209512941294.033.8433.8Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. Y ShaiBiochim Biophys Acta199910590302No
209612941294.029.5329.5Cancer of the ovary. Stephen A CannistraN Engl J Med200415590954No
209712931293.041.7841.8Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. A A GraceNeuroscience19911676137No
209825851292.567.1733.6Long short-term memory. S Hochreiter, J SchmidhuberNeural Comput19979377276Yes
209912921292.00.00.0Stability of proteins: small globular proteins. P L PrivalovAdv Protein Chem197944431No
210025841292.061.930.9Production of single-stranded plasmid DNA. J Vieira, J MessingMethods Enzymol19873323803Yes
210112921292.050.2350.2Presidential address, 1980. Surprise!...Surprise? E DonchinPsychophysiology19817280146Yes
210212921292.030.2130.2Autophagy: from phenomenology to molecular understanding in less than a decade. Daniel J KlionskyNat Rev Mol Cell Biol200717712358No
210338731291.0102.7134.2Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. B Fischl, M I Sereno, A M DaleNeuroimage19999931269Yes
210412901290.030.5930.6Molecular basis of long-term plasticity underlying addiction. E J NestlerNat Rev Neurosci200111252991No
210512901290.036.3736.4Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Michael F HolickAm J Clin Nutr200415585788No
210612901290.047.4447.4The global impact of pre-eclampsia and eclampsia. Lelia DuleySemin Perinatol200919464502No
210712891289.033.233.2A molecular view of microbial diversity and the biosphere. N R PaceScience19979115194No
210812891289.024.2824.3Chromatin modification and epigenetic reprogramming in mammalian development. En LiNat Rev Genet200212209141No
210925771288.50.00.0Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. L F Berkman, S L SymeAm J Epidemiol1979425958Yes
211012881288.028.2428.2The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. G B MorinCell19892805070Yes
211138631287.70.00.0Improved method for the determination of blood glutathione. E Beutler, O Duron, B M KellyJ Lab Clin Med196313967893Yes
211225741287.00.00.0Epidermal growth factor. G Carpenter, S CohenAnnu Rev Biochem1979382984No
211325741287.00.00.0A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. R L Juliano, V LingBiochim Biophys Acta1976990323Yes
211425741287.00.00.0A new scale of social desirability independent of psychopathology. D P Crowne, D MarloweJ Consult Psychol196013813058Yes
211525721286.00.00.0Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. J A Ledbetter, L A HerzenbergImmunol Rev1979398327No
211612861286.00.00.0Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. A BöyumScand J Clin Lab Invest Suppl19684179066Yes
211712861286.022.3422.3Cancer. Addiction to oncogenes--the Achilles heal of cancer. I Bernard WeinsteinScience200212098689No
211825711285.559.7529.9Disruption of epithelial cell-matrix interactions induces apoptosis. S M Frisch, H FrancisJ Cell Biol19948106557Yes
211912851285.031.1431.1Receptors for epidermal growth factor and other polypeptide mitogens. G CarpenterAnnu Rev Biochem19873039909No
212012851285.047.1947.2Substance P. B PernowPharmacol Rev19836196797No
212125701285.054.8127.4Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. J M Kyriakis, J AvruchPhysiol Rev200111274345No
212212851285.045.2545.2Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. K Anders EricssonAcad Med200415383395No
212325701285.082.2241.1Protective and pathogenic functions of macrophage subsets. Peter J Murray, Thomas A WynnNat Rev Immunol201121997792No
212425681284.00.00.0Regulatory sequences involved in the promotion and termination of RNA transcription. M Rosenberg, D CourtAnnu Rev Genet197994251No
212512841284.00.00.0Mate selection-a selection for a handicap. A ZahaviJ Theor Biol19751195756Yes
212612841284.034.8134.8Signaling through phosphatidylcholine breakdown. J H ExtonJ Biol Chem19902104616No
212712841284.034.2934.3Phylogenies from molecular sequences: inference and reliability. J FelsensteinAnnu Rev Genet19883071258No
212812841284.026.5526.6Natively unfolded proteins: a point where biology waits for physics. Vladimir N UverskyProtein Sci200211910019No
212925681284.056.9928.5NMR View: A computer program for the visualization and analysis of NMR data. B A Johnson, R A BlevinsJ Biomol NMR199422911360Yes
213038501283.3139.0746.4Structure-antioxidant activity relationships of flavonoids and phenolic acids. C A Rice-Evans, N J Miller, G PagangaFree Radic Biol Med19968743980Yes
213112831283.029.2629.3The ATP synthase--a splendid molecular machine. P D BoyerAnnu Rev Biochem19979242922No
213212831283.035.6935.7A note on robust variance estimation for cluster-correlated data. R L WilliamsBiometrics200010877330Yes
213312831283.024.3324.3CD95's deadly mission in the immune system. P H KrammerNature200011048730No
213425661283.051.6725.8Autophagy as a regulated pathway of cellular degradation. D J Klionsky, S D EmrScience200011099404No
213512831283.00.00.0The Relation Of Recombination To Mutational Advance. H J MullerMutat Res196414195748Yes
213612831283.032.6832.7Upconversion and anti-Stokes processes with f and d ions in solids. François AuzelChem Rev200414719973Yes
213751301282.5225.6956.4Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanInt J Surg201020171303No
213825641282.060.2930.1A comparison of bayesian methods for haplotype reconstruction from population genotype data. Matthew Stephens, Peter DonnellyAm J Hum Genet200314574645Yes
213912821282.034.134.1Origin, biogenesis, and activity of plant microRNAs. Olivier VoinnetCell200919239888No
214012811281.00.00.0Cardiovascular and renal actions of dopamine: potential clinical applications. L I GoldbergPharmacol Rev19724554480No
214151211280.2128.5832.1Improved prediction of signal peptides: SignalP 3.0. Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren BrunakJ Mol Biol200415223320Yes
214212801280.00.00.0Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. J H LuftAnat Rec19714108333Yes
214312791279.085.1385.1The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. F DenisSpine (Phila Pa 1976)19836670016Yes
214412781278.055.4555.5The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. E J KhantzianAm J Psychiatry19853904487No
214512781278.032.9533.0Drug-induced prolongation of the QT interval. Dan M RodenN Engl J Med200414999113No
214625551277.576.2738.1Lipid rafts as a membrane-organizing principle. Daniel Lingwood, Kai SimonsScience201020044567No
214738311277.0183.261.1Risk factors for falls among elderly persons living in the community. M E Tinetti, M Speechley, S F GinterN Engl J Med19883205267Yes
214812771277.00.00.0Hippocampal electrical activity and voluntary movement in the rat. C H VanderwolfElectroencephalogr Clin Neurophysiol19694183562Yes
214912771277.030.8230.8Lymphokine production by human T cells in disease states. S RomagnaniAnnu Rev Immunol19948011282No
215012771277.035.5835.6The epidemiology of venous thromboembolism. Richard H WhiteCirculation200312814979No
215112771277.039.9940.0Recent developments in isocyanide based multicomponent reactions in applied chemistry. Alexander DömlingChem Rev200616402771No
215212771277.059.3259.3KDIGO clinical practice guidelines for acute kidney injury. Arif KhwajaNephron Clin Pract201222890468No
215325521276.00.00.0A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. B G Durie, S E SalmonCancer19751182674Yes
215412761276.024.2424.2Antigen-specific interaction between T and B cells. A LanzavecchiaNature19853157869Yes
215512761276.044.7944.8Functional organization of central pathways regulating the cardiovascular system. R A DampneyPhysiol Rev19948171117No
215625491274.547.523.8New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. R D Gietz, A SuginoGene19883073106Yes
215712741274.033.8233.8The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. T SzkudelskiPhysiol Res200111829314No
215850941273.5129.6732.4The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten SchwedeBioinformatics200616301204Yes
215925461273.043.0921.5Genetic transformation of Drosophila with transposable element vectors. G M Rubin, A C SpradlingScience19826289436Yes
216012731273.034.4334.4The importance of the ratio of omega-6/omega-3 essential fatty acids. A P SimopoulosBiomed Pharmacother200212442909No
216125451272.555.1427.6A guided tour into subcellular colocalization analysis in light microscopy. S Bolte, F P CordelièresJ Microsc200617210054Yes
216212721272.038.9138.9Diversity and ubiquity of K channels. B RudyNeuroscience19882457185No
216312721272.023.7623.8The snail superfamily of zinc-finger transcription factors. M Angela NietoNat Rev Mol Cell Biol200211994736No
216412721272.046.7846.8A Social Neuroscience Perspective on Adolescent Risk-Taking. Laurence SteinbergDev Rev200818509515Yes
216512711271.023.2523.2Regulatory T cells: key controllers of immunologic self-tolerance. S SakaguchiCell200010850488No
216625421271.081.8140.9A perspective on cancer cell metastasis. Christine L Chaffer, Robert A WeinbergScience201121436443No
216712711271.00.00.0Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. Russell LandeEvolution197928568194Yes
216825401270.087.6443.8Thermodynamics of protein association reactions: forces contributing to stability. P D Ross, S SubramanianBiochemistry19817248271Yes
216925391269.50.00.0Glutathione peroxidase activity in selenium-deficient rat liver. R A Lawrence, R F BurkBiochem Biophys Res Commun1976971321Yes
217025391269.591.0545.5Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. M M Bradley, P J LangJ Behav Ther Exp Psychiatry19947962581Yes
217125381269.00.00.0Establishment and characterization of a human histiocytic lymphoma cell line (U-937). C Sundström, K NilssonInt J Cancer1976178611Yes
217212691269.041.9241.9Somatostatin. S ReichlinN Engl J Med19836139753No
217312691269.029.2829.3Critical period plasticity in local cortical circuits. Takao K HenschNat Rev Neurosci200516261181No
217412681268.045.4445.4The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. E J KhantzianHarv Rev Psychiatry19979385000No
217525351267.50.00.0Functions of lysosomes. C De Duve, R WattiauxAnnu Rev Physiol19665322983No
217625351267.555.4627.7Liver regeneration. G K Michalopoulos, M C DeFrancesScience19979082986No
217725331266.50.00.0The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. J Shine, L DalgarnoProc Natl Acad Sci U S A19744598299Yes
217812661266.022.7722.8Clonal selection and learning in the antibody system. K RajewskyNature19968657279No
217912661266.029.0129.0Target-oriented and diversity-oriented organic synthesis in drug discovery. S L SchreiberScience200010720315No
218012661266.00.00.0A New Weighting System For Mean Surface Temperature Of The Human Body. N L RamanathanJ Appl Physiol196414173555Yes
218125301265.00.00.0A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. J A Horne, O OstbergInt J Chronobiol19761027738Yes
218212651265.048.0348.0The life and times of the Enterococcus. B E MurrayClin Microbiol Rev19902404568No
218312651265.00.00.0The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. R G KhalifahJ Biol Chem19714994926Yes
218425281264.049.8424.9Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. M Fried, D M CrothersNucleic Acids Res19816275366Yes
218512641264.042.1742.2Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Thomas HebererToxicol Lett200211988354Yes
218612641264.033.8633.9Interoception: the sense of the physiological condition of the body. A D CraigCurr Opin Neurobiol200312965300No
218725261263.00.00.0A rapid, sensitive, and specific method for the determination of protein in dilute solution. W Schaffner, C WeissmannAnal Biochem19734128882Yes
218837871262.3118.7939.6Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. S van der Linden, H A Valkenburg, A CatsArthritis Rheum19846231933Yes
218925241262.00.00.0Prediction of the secondary structure of proteins from their amino acid sequence. P Y Chou, G D FasmanAdv Enzymol Relat Areas Mol Biol1978364941No
219012621262.051.151.1Reliability and factor analysis of the Epworth Sleepiness Scale. M W JohnsSleep19921519015Yes
219112621262.040.3640.4Biological basis of the behavior of sick animals. B L HartNeurosci Biobehav Rev19883050629No
219212621262.028.2928.3Stability and flexibility of epigenetic gene regulation in mammalian development. Wolf ReikNature200717522676No
219337841261.3105.3735.1TCS: a computer program to estimate gene genealogies. M Clement, D Posada, K A CrandallMol Ecol200011050560Yes
219412611261.033.7233.7The aryl hydrocarbon receptor complex. O HankinsonAnnu Rev Pharmacol Toxicol19957598497No
219537831261.0103.1834.4The metabolic syndrome. Robert H Eckel, Scott M Grundy, Paul Z ZimmetLancet200515836891No
219612611261.038.4338.4The debate over dopamine's role in reward: the case for incentive salience. Kent C BerridgePsychopharmacology (Berl)200717072591No
219725211260.562.5331.3Multipoint quantitative-trait linkage analysis in general pedigrees. L Almasy, J BlangeroAm J Hum Genet19989545414Yes
219812601260.042.6842.7SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. B P O'ConnorBehav Res Methods Instrum Comput200011029811Yes
219925201260.088.3544.2The pathogenesis of rheumatoid arthritis. Iain B McInnes, Georg SchettN Engl J Med201122150039No
220012591259.00.00.0The prevalence of 'alexithymic' characteristics in psychosomatic patients. P E SifneosPsychother Psychosom19734770536Yes
220112591259.033.4433.4Supported membranes: scientific and practical applications. E SackmannScience19968539599No
220212591259.035.4135.4Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. P LipsEndocr Rev200111493580No
220312591259.043.6443.6The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. Poul Erik PetersenCommunity Dent Oral Epidemiol200315015736Yes
220412591259.022.9823.0Protein modification by SUMO. Erica S JohnsonAnnu Rev Biochem200415189146No
220512591259.030.8630.9Cell signaling. H2O2, a necessary evil for cell signaling. Sue Goo RheeScience200616809515Yes
220612581258.00.00.0Structure and function of intercellular junctions. L A StaehelinInt Rev Cytol19744611943No
220712581258.042.3242.3Formation of glasses from liquids and biopolymers. C A AngellScience199517770101Yes
220862851257.00.00.0Enzymatic determination of total serum cholesterol. C C Allain, L S Poon, C S Chan, W Richmond, P C FuClin Chem19744818200Yes
220912571257.00.00.0Strategy and tactics in protein chemistry. B S HartleyBiochem J19704923920No
221025141257.076.6838.3What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. J Zhang, K F YuJAMA19989832001Yes
221112571257.033.8633.9Hemispheric asymmetry reduction in older adults: the HAROLD model. Roberto CabezaPsychol Aging200211931290No
221212571257.023.9624.0The significance of responses of the genome to challenge. B McClintockScience198415739260No
221312571257.048.3748.4Functional and effective connectivity: a review. Karl J FristonBrain Connect201122432952No
221412561256.052.3852.4Error in medicine. L L LeapeJAMA19947503827Yes
221512561256.026.1926.2SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. S V EvansJ Mol Graph19938347566Yes
221612561256.031.8931.9Apoptosis. J J CohenImmunol Today19938466628No
221712561256.035.9636.0Synergy, antagonism, and what the chequerboard puts between them. F C OddsJ Antimicrob Chemother200312805255No
221825101255.067.6533.8Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. J L Weber, P E MayAm J Hum Genet19892916582Yes
221912551255.047.6347.6Quantitative methods in the review of epidemiologic literature. S GreenlandEpidemiol Rev19873678409Yes
222012551255.043.2143.2Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. R LotanBiochim Biophys Acta19806989400No
222112551255.037.0937.1Bioactive microbial metabolites. János BérdyJ Antibiot (Tokyo)200515813176No
222212541254.026.2926.3Signal transduction via the MAP kinases: proceed at your own RSK. J BlenisProc Natl Acad Sci U S A19938392180No
222337621254.094.431.5Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Daniel Falush, Matthew Stephens, Jonathan K PritchardGenetics200312930761Yes
222412541254.029.7229.7Mitochondria: dynamic organelles in disease, aging, and development. David C ChanCell200616814712No
222512541254.046.6746.7Matching methods for causal inference: A review and a look forward. Elizabeth A StuartStat Sci201020871802Yes
222637601253.3101.3633.8How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. R M Sapolsky, L M Romero, A U MunckEndocr Rev200010696570No
222725061253.078.7739.4miRBase: integrating microRNA annotation and deep-sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201121037258Yes
222812521252.025.8425.8Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. R H SchwartzCell19921335362No
222912521252.00.00.0Limitations of the application of fourfold table analysis to hospital data. J BerksonBiometrics194621001024Yes
223025041252.075.0637.5Molecular mechanisms of long noncoding RNAs. Kevin C Wang, Howard Y ChangMol Cell201121925379No
223125001250.058.1329.1DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. S Tabor, C C RichardsonProc Natl Acad Sci U S A19873474623Yes
223212491249.038.2438.2Osteoblast adhesion on biomaterials. K AnselmeBiomaterials200010711964No
223324971248.569.1234.6Abdominal obesity and metabolic syndrome. Jean-Pierre Després, Isabelle LemieuxNature200617167477No
223424971248.580.8640.4Astrocytes: biology and pathology. Michael V Sofroniew, Harry V VintersActa Neuropathol201020012068No
223512481248.028.7728.8Chemistry and biology of the immunophilins and their immunosuppressive ligands. S L SchreiberScience19911702904No
223612481248.028.3728.4Life, death, and the pursuit of apoptosis. E WhiteGenes Dev19968557188No
223712481248.00.00.0A modification of receptor theory. R P StephensonBr J Pharmacol Chemother195613383117Yes
223812471247.044.7744.8Carnitine--metabolism and functions. J BremerPhysiol Rev19836361812No
223912471247.028.428.4Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. T A SpringerAnnu Rev Physiol19957778885No
224012471247.039.8939.9Ordinary magic. Resilience processes in development. A S MastenAm Psychol200111315249Yes
224137401246.783.9528.0Multidrug resistance in cancer: role of ATP-dependent transporters. Michael M Gottesman, Tito Fojo, Susan E BatesNat Rev Cancer200211902585No
224224931246.583.8241.9The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. W R Gibb, A J LeesJ Neurol Neurosurg Psychiatry19882841426No
224387231246.1272.3938.9Cancer statistics, 2008. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J ThunCA Cancer J Clin200818287387Yes
224412461246.027.327.3Codon usage and tRNA content in unicellular and multicellular organisms. T IkemuraMol Biol Evol19853916708No
224524921246.00.00.0The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. B N Ames, D T DubinJ Biol Chem196013793161Yes
224637371245.778.9726.3The versatility and universality of calcium signalling. M J Berridge, P Lipp, M D BootmanNat Rev Mol Cell Biol200011413485No
224724911245.555.8727.9Mitochondrial control of cell death. G Kroemer, J C ReedNat Med200010802706No
224824911245.562.9931.5Inflammation, stress, and diabetes. Kathryn E Wellen, Gökhan S HotamisligilJ Clin Invest200515864338No
224937341244.782.1527.4A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. R Medzhitov, P Preston-Hurlburt, C A JanewayNature19979237759Yes
225024891244.555.4927.7Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. M Zuker, P StieglerNucleic Acids Res19816163133Yes
225112441244.030.5330.5Short-term synaptic plasticity. R S ZuckerAnnu Rev Neurosci19892648947No
225224881244.066.3133.2Apoptosis, oncosis, and necrosis. An overview of cell death. G Majno, I JorisAm J Pathol19957856735No
225324861243.00.00.0Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. A Fabiato, F FabiatoJ Physiol (Paris)1979533865Yes
225412431243.020.6420.6Antigen receptor tail clue. M RethNature19892927501Yes
225524861243.087.8843.9The framing of decisions and the psychology of choice. A Tversky, D KahnemanScience19817455683Yes
225612431243.00.00.0The effective period of preventive antibiotic action in experimental incisions and dermal lesions. J F BurkeSurgery196116722001Yes
225712421242.030.3730.4Papillomavirus infections--a major cause of human cancers. H zur HausenBiochim Biophys Acta19968876633No
225812421242.032.8532.9Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. R M SapolskyArch Gen Psychiatry200011015810No
225912421242.035.6135.6Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. E B HunzikerOsteoarthritis Cartilage200212056848No
226012411241.039.5839.6Graphene transistors. Frank SchwierzNat Nanotechnol201020512128Yes
226112401240.067.1567.2The determinants of parenting: a process model. J BelskyChild Dev19846705636Yes
226212401240.062.5462.5Chronic illness as biographical disruption. M BurySociol Health Illn198210260456Yes
226312401240.034.1834.2Understanding biofilm resistance to antibacterial agents. David DaviesNat Rev Drug Discov200312563302No
226424781239.093.7846.9Universal chemical assay for the detection and determination of siderophores. B Schwyn, J B NeilandsAnal Biochem19872952030Yes
226549551238.8149.4237.4Reversible middle cerebral artery occlusion without craniectomy in rats. E Z Longa, P R Weinstein, S Carlson, R CumminsStroke19892643202Yes
226624761238.073.1236.6Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. J I Morgan, T CurranAnnu Rev Neurosci19911903243No
226712381238.025.8625.9Searching for genetic determinants in the new millennium. N J RischNature200010866211No
226812381238.026.7126.7The many faces of macrophage activation. David M MosserJ Leukoc Biol200312554797No
226912381238.043.0343.0Stress and disorders of the stress system. George P ChrousosNat Rev Endocrinol200919488073No
227024751237.556.7428.4Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. D A Brown, J K RoseCell19921531449Yes
227112371237.00.00.0Bee and wasp venoms. E HabermannScience19724113805No
227212371237.042.4742.5How is the level of free arachidonic acid controlled in mammalian cells? R F IrvineBiochem J19826810878No
227312371237.039.5839.6A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Ozcan ErelClin Biochem200415003729Yes
227412371237.033.0533.0Clinical features of metastatic bone disease and risk of skeletal morbidity. Robert E ColemanClin Cancer Res200617062708No
227512371237.039.239.2Understanding organofluorine chemistry. An introduction to the C-F bond. David O'HaganChem Soc Rev200818197347No
227612361236.039.0139.0Strong localization of photons in certain disordered dielectric superlattices. JohnPhys Rev Lett198710034761Yes
227724721236.057.4928.7Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Joshua E Elias, Steven P GygiNat Methods200717327847Yes
2278111221235.8356.3739.6The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C DunbarJ Clin Psychiatry19989881538No
227937071235.7113.3137.8I-TASSER: a unified platform for automated protein structure and function prediction. Ambrish Roy, Alper Kucukural, Yang ZhangNat Protoc201020360767Yes
228024711235.574.7237.4The Measurement Of Selection On Correlated Characters. Russell Lande, Stevan J ArnoldEvolution198328556011Yes
228124701235.045.9223.0Rab proteins as membrane organizers. M Zerial, H McBrideNat Rev Mol Cell Biol200111252952No
228224701235.052.1426.1Short-term synaptic plasticity. Robert S Zucker, Wade G RegehrAnnu Rev Physiol200211826273No
228312351235.00.00.0Sequential tests for the detection of linkage. N E MortonAm J Hum Genet195513258560Yes
228412351235.037.8537.9Treatment of infections associated with surgical implants. Rabih O DarouicheN Engl J Med200415070792No
228512351235.045.8145.8Phase retrieval algorithms: a comparison. J R FienupAppl Opt198220396114Yes
228661731234.6810.24162.0MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro TamuraMol Biol Evol201829722887Yes
228712341234.00.00.0The origin of the genetic code. F H CrickJ Mol Biol19684887876Yes
228812341234.025.8325.8Endocytosis and molecular sorting. I MellmanAnnu Rev Cell Dev Biol19968970738No
228912341234.023.1823.2c-Myc target genes involved in cell growth, apoptosis, and metabolism. C V DangMol Cell Biol19999858526No
229012341234.00.00.0On the local reactions of the arterial wall to changes of internal pressure. W M BaylissJ Physiol190216992618Yes
229174011233.5204.4334.1Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur WheelerN Engl J Med200010793162Yes
229212331233.045.0845.1The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. A RaineSchizophr Bull19911805349Yes
229312331233.027.4627.5HIF-1: mediator of physiological and pathophysiological responses to hypoxia. G L SemenzaJ Appl Physiol (1985)200010749844No
229424651232.590.8945.4The stunned myocardium: prolonged, postischemic ventricular dysfunction. E Braunwald, R A KlonerCirculation19826754130No
229524641232.052.1526.1The molecular biology of axon guidance. M Tessier-Lavigne, C S GoodmanScience19968895455No
229624641232.00.00.0Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. G J Todaro, H GreenJ Cell Biol196313985244Yes
229761581231.6150.830.2Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L CoffmanJ Immunol19862419430Yes
229836941231.3145.048.3CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Teresa C Horan, Mary Andrus, Margaret A DudeckAm J Infect Control200818538699No
229912311231.024.9625.0STATs: signal transducers and activators of transcription. J N IhleCell19968608586No
230012311231.060.5760.6Whatever next? Predictive brains, situated agents, and the future of cognitive science. Andy ClarkBehav Brain Sci201323663408No
230112301230.030.7530.8The 'effective number of codons' used in a gene. F WrightGene19902110097Yes
230261461229.2191.8338.4Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939839Yes
230312291229.030.3730.4Proinflammatory cytokines. C A DinarelloChest200010936147No
230424581229.064.9832.5Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. M P Lutolf, J A HubbellNat Biotechnol200515637621No
230524581229.058.5229.3Cellular senescence: when bad things happen to good cells. Judith Campisi, Fabrizio d'Adda di FagagnaNat Rev Mol Cell Biol200717667954No
230612291229.054.8854.9Cognitive reserve in ageing and Alzheimer's disease. Yaakov SternLancet Neurol201223079557No
230712281228.00.00.0Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. P RakicJ Comp Neurol19714101340Yes
230812281228.029.6229.6Refined structure of the nicotinic acetylcholine receptor at 4A resolution. Nigel UnwinJ Mol Biol200515701510Yes
230912281228.047.4647.5Asthma phenotypes: the evolution from clinical to molecular approaches. Sally E WenzelNat Med201222561835No
231012271227.034.8434.8Tumor angiogenesis. J FolkmanAdv Cancer Res19852581424No
231112271227.00.00.0A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. A M OlovnikovJ Theor Biol19734754905Yes
231212271227.00.00.0Disconnexion syndromes in animals and man. I. N GeschwindBrain19655318481No
231312271227.036.536.5Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. P WillnerPsychopharmacology (Berl)19979452163No
231424541227.047.9124.0Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. C Li, W H WongProc Natl Acad Sci U S A200111134512Yes
231524541227.055.4527.7LTP and LTD: an embarrassment of riches. Robert C Malenka, Mark F BearNeuron200415450156No
231636801226.7137.2145.7Global estimates of the prevalence of diabetes for 2010 and 2030. J E Shaw, R A Sicree, P Z ZimmetDiabetes Res Clin Pract201019896746Yes
231761301226.0236.8647.4Evidence based medicine: what it is and what it isn't. D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S RichardsonBMJ19968555924No
231824521226.080.1340.1Porosity of 3D biomaterial scaffolds and osteogenesis. Vassilis Karageorgiou, David KaplanBiomaterials200515860204No
231912251225.022.4322.4Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. H E RuleyNature19836308473Yes
232012251225.027.327.3Maintenance of C. elegans. Theresa StiernagleWormBook200618050451No
232124491224.549.5924.8Prediction of complete gene structures in human genomic DNA. C Burge, S KarlinJ Mol Biol19979149143Yes
232212241224.030.9430.9Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. J DeisenhoferBiochemistry19817236608Yes
232312241224.040.6140.6An application of prefrontal cortex function theory to cognitive aging. R L WestPsychol Bull19968831298No
232424471223.562.5831.3Interneurons of the hippocampus. T F Freund, G BuzsákiHippocampus19968915675No
232512231223.036.8136.8The origins of the developmental origins theory. D J P BarkerJ Intern Med200717444880No
232612231223.00.00.0Observations on the isolated phrenic nerve diaphragm preparation of the rat. E BulbringBr J Pharmacol Chemother194620999334Yes
232712221222.00.00.0Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. P O SeglenExp Cell Res19734358115Yes
232812221222.037.4637.5Calcium channel modulation by neurotransmitters, enzymes and drugs. H ReuterNature19836131381No
232924441222.062.0731.0Pharmacology and functions of metabotropic glutamate receptors. P J Conn, J P PinAnnu Rev Pharmacol Toxicol19979131252No
233012211221.00.00.0A restriction point for control of normal animal cell proliferation. A B PardeeProc Natl Acad Sci U S A19744524638Yes
233112211221.037.237.2Circuitry and functional aspects of the insular lobe in primates including humans. J R AugustineBrain Res Brain Res Rev19968957561No
233236611220.3167.6255.9In search of how people change. Applications to addictive behaviors. J O Prochaska, C C DiClemente, J C NorcrossAm Psychol19921329589Yes
233324401220.00.00.0Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. G K McMaster, G G CarmichaelProc Natl Acad Sci U S A197773185Yes
233424391219.595.7747.9Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Jennifer A Doudna, Emmanuelle CharpentierScience201425430774No
233512191219.00.00.0The intraclass correlation coefficient as a measure of reliability. J J BartkoPsychol Rep19665942109Yes
233624381219.063.4531.7Genetic dissection of complex traits. E S Lander, N J SchorkScience19948091226No
233712191219.00.00.0On the psychophysical law. S S StevensPsychol Rev195713441853Yes
233860931218.60.00.0Transection of the oesophagus for bleeding oesophageal varices. R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R WilliamsBr J Surg19734541913Yes
233912181218.038.1138.1Classification of chronic viral hepatitis: a need for reassessment. P J ScheuerJ Hepatol19911808228No
234024351217.576.9538.5Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J E Hixson, D T VernierJ Lipid Res19902341813Yes
234124351217.563.9532.0The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Clay B Holroyd, Michael G H ColesPsychol Rev200212374324Yes
234224351217.5168.0784.0Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. Ivica Letunic, Peer BorkNucleic Acids Res201627095192Yes
234312171217.00.00.0The critical incident technique. J C FlanaganPsychol Bull195413177800Yes
234412161216.039.5639.6The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. J L CummingsNeurology19979153155No
234512161216.024.6924.7Cytokines induce the development of functionally heterogeneous T helper cell subsets. A O'GarraImmunity19989529145No
234672941215.7275.0145.8TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L SalzbergGenome Biol201323618408Yes
234712151215.031.631.6Rapid evolution of a protein in vitro by DNA shuffling. W P StemmerNature19948047147Yes
234824291214.561.2230.6Molecular mechanisms of action of steroid/thyroid receptor superfamily members. M J Tsai, B W O'MalleyAnnu Rev Biochem19947979245No
234924291214.574.5137.3Epidemiology of invasive candidiasis: a persistent public health problem. M A Pfaller, D J DiekemaClin Microbiol Rev200717223626No
235024291214.571.9436.0Regulation of chromatin by histone modifications. Andrew J Bannister, Tony KouzaridesCell Res201121321607No
235112141214.00.00.0The biologic clock: the mitochondria? D HarmanJ Am Geriatr Soc19725016631Yes
235224281214.00.00.0High resolution acrylamide gel electrophoresis of histones. S Panyim, R ChalkleyArch Biochem Biophys19695778650Yes
235312141214.027.0427.0Heterotrimeric G proteins: organizers of transmembrane signals. E J NeerCell19957834744No
235412141214.031.0431.0Endothelial-leukocyte adhesion molecules. M P BevilacquaAnnu Rev Immunol19938476577No
235512141214.028.9528.9Oxyradicals and DNA damage. L J MarnettCarcinogenesis200010688856No
235612141214.029.7229.7Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? Rui WangFASEB J200212409322Yes
235724281214.00.00.0Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. H A Edmondson, P E SteinerCancer195413160935Yes
235812141214.00.00.0Diversity in tropical rain forests and coral reefs. J H ConnellScience197817840770Yes
235912141214.043.643.6Aging, cellular senescence, and cancer. Judith CampisiAnnu Rev Physiol201323140366No
236012131213.042.942.9The theoretical bases of indirect calorimetry: a review. E FerranniniMetabolism19883278194No
236124261213.088.5844.3Total energy intake: implications for epidemiologic analyses. W Willett, M J StampferAm J Epidemiol19863521261No
236212131213.046.4446.4UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. D W RussellJ Pers Assess19968576833Yes
236312131213.041.041.0The law of attrition. Gunther EysenbachJ Med Internet Res200515829473Yes
236412131213.031.0731.1Fast and robust fixed-point algorithms for independent component analysis. A HyvärinenIEEE Trans Neural Netw199918252563Yes
236524251212.567.9334.0Nitric oxide synthases: roles, tolls, and controls. C Nathan, Q W XieCell19947522969No
236612121212.033.9834.0Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. F HeftiJ Neurosci19863746405Yes
236712121212.046.3646.4The structure of beta-lactamases. R P AmblerPhilos Trans R Soc Lond B Biol Sci19806109327Yes
236824231211.565.3632.7The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Daniel J Drucker, Michael A NauckLancet200617098089No
236924231211.577.7538.9Genome regulation by long noncoding RNAs. John L Rinn, Howard Y ChangAnnu Rev Biochem201222663078No
237012111211.031.2131.2The mitochondrial electron transport and oxidative phosphorylation system. Y HatefiAnnu Rev Biochem19852862839No
237112111211.021.6221.6The economics of ribosome biosynthesis in yeast. J R WarnerTrends Biochem Sci199910542411No
237224221211.069.034.5Bronchopulmonary dysplasia. A H Jobe, E BancalariAm J Respir Crit Care Med200111401896No
237312111211.028.5528.6Topoisomerase I inhibitors: camptothecins and beyond. Yves PommierNat Rev Cancer200616990856No
237424211210.571.8835.9The gut microbiota shapes intestinal immune responses during health and disease. June L Round, Sarkis K MazmanianNat Rev Immunol200919343057No
237524211210.561.330.6The DNA damage response: making it safe to play with knives. Alberto Ciccia, Stephen J ElledgeMol Cell201020965415No
237612101210.022.7722.8SUMO: a history of modification. Ronald T HayMol Cell200515808504No
237724191209.564.7332.4Powering the planet: chemical challenges in solar energy utilization. Nathan S Lewis, Daniel G NoceraProc Natl Acad Sci U S A200617043226Yes
237824171208.555.5927.8Escaping free-energy minima. Alessandro Laio, Michele ParrinelloProc Natl Acad Sci U S A200212271136Yes
237924161208.039.5519.8A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. D Tautz, C PfeifleChromosoma19892476281Yes
238036241208.097.6432.5Cognitive and emotional influences in anterior cingulate cortex. Bush, Luu, PosnerTrends Cogn Sci200010827444Yes
238124161208.046.1523.1Live or let die: the cell's response to p53. Karen H Vousden, Xin LuNat Rev Cancer200212154352No
238212081208.033.7633.8Genetic consequences of climatic oscillations in the Quaternary. G M HewittPhilos Trans R Soc Lond B Biol Sci200415101575No
238360361207.2156.831.4Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory CollinsLancet200212493255Yes
238412071207.038.2938.3Linkage map of Escherichia coli K-12, edition 7. B J BachmannMicrobiol Rev19836348505No
238512071207.035.2835.3Peptide antibiotics and their role in innate immunity. H G BomanAnnu Rev Immunol19957612236No
238612071207.038.5838.6Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). Gunther EysenbachJ Med Internet Res200415471760No
238712071207.033.0633.1Marine viruses--major players in the global ecosystem. Curtis A SuttleNat Rev Microbiol200717853907No
238812071207.041.4741.5Signal transduction by reactive oxygen species. Toren FinkelJ Cell Biol201121746850No
238924131206.551.9326.0Regulated portals of entry into the cell. Sean D Conner, Sandra L SchmidNature200312621426No
239060311206.2193.2138.6Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. J S Beckman, T W Beckman, J Chen, P A Marshall, B A FreemanProc Natl Acad Sci U S A19902154753Yes
2391132681206.2380.434.6The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J RoccellaJAMA200312748199No
239212061206.059.3759.4New norms of upper limb fat and muscle areas for assessment of nutritional status. A R FrisanchoAm J Clin Nutr19816975564Yes
239324121206.059.1429.6Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Jane E Visvader, Geoffrey J LindemanNat Rev Cancer200818784658No
239424121206.0112.8456.4Natural products as sources of new drugs over the 30 years from 1981 to 2010. David J Newman, Gordon M CraggJ Nat Prod201222316239No
239524111205.50.00.0Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. J M Tanner, R H WhitehouseArch Dis Child1976952550Yes
239648211205.2143.2835.8Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Weidner, J P Semple, W R Welch, J FolkmanN Engl J Med19911701519Yes
239712051205.026.1426.1Antigen-presenting function of the macrophage. E R UnanueAnnu Rev Immunol19846242349No
239812051205.034.9234.9Polycystic ovary syndrome. David A EhrmannN Engl J Med200515788499No
239924101205.070.3135.2Molecular replacement with MOLREP. Alexei Vagin, Alexei TeplyakovActa Crystallogr D Biol Crystallogr201020057045Yes
240036141204.786.6228.9Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. Christian W Tornøe, Caspar Christensen, Morten MeldalJ Org Chem200211975567Yes
240112041204.029.8329.8Bcl-2 initiates a new category of oncogenes: regulators of cell death. S J KorsmeyerBlood19921498330No
240212041204.055.4355.4Continuous improvement as an ideal in health care. D M BerwickN Engl J Med19892909878Yes
240324071203.50.00.0The Aggregation Of Blood Platelets. G V Born, M J CrossJ Physiol196314056485Yes
240424061203.074.3837.2An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Sun Ho Kim, Jin Mo ChungPain19921333581Yes
240512031203.00.00.0Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. W D HamiltonScience19676021675Yes
240624061203.079.1239.6Oxidative mechanisms in the toxicity of metal ions. S J Stohs, D BagchiFree Radic Biol Med19957744317No
240712031203.027.8427.8Physiological and molecular basis of thyroid hormone action. P M YenPhysiol Rev200111427693No
240824061203.095.7547.9The integrative review: updated methodology. Robin Whittemore, Kathleen KnaflJ Adv Nurs200516268861Yes
240912021202.034.0534.0Diversity of group types, regulation, and function of phospholipase A2. E A DennisJ Biol Chem19948175726No
241012021202.025.4125.4MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. R N GermainCell19948293464No
241112021202.026.3426.3Dendritic cells: unique leukocyte populations which control the primary immune response. D N HartBlood19979345009No
241212021202.024.4324.4Mechanisms of caspase activation and inhibition during apoptosis. Yigong ShiMol Cell200211931755No
241312021202.00.00.0The anterior approach for removal of ruptured cervical disks. R B ClowardJ Neurosurg195813599052Yes
241412021202.00.00.0Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. J M Van RossumArch Int Pharmacodyn Ther196313996119Yes
241512021202.035.2435.2Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Arnold I CaplanJ Cell Physiol200717620285No
241612021202.041.5341.5Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. Chao-Jun LiAcc Chem Res200919220064Yes
241736051201.7112.837.6A rapid bootstrap algorithm for the RAxML Web servers. Alexandros Stamatakis, Paul Hoover, Jacques RougemontSyst Biol200818853362Yes
241824031201.565.7932.9Cell signaling by receptor tyrosine kinases. Mark A Lemmon, Joseph SchlessingerCell201020602996No
241936041201.3110.4336.8Oxidants, antioxidants, and the degenerative diseases of aging. B N Ames, M K Shigenaga, T M HagenProc Natl Acad Sci U S A19938367443No
242012011201.040.4540.5Chlorophyll fluorescence: a probe of photosynthesis in vivo. Neil R BakerAnnu Rev Plant Biol200818444897No
242136021200.7129.743.2A new method for off-line removal of ocular artifact. G Gratton, M G Coles, E DonchinElectroencephalogr Clin Neurophysiol19836187540Yes
242224011200.564.6232.3A globally coherent fingerprint of climate change impacts across natural systems. Camille Parmesan, Gary YoheNature200312511946Yes
242311991199.036.4836.5Qinghaosu (artemisinin): an antimalarial drug from China. D L KlaymanScience19853887571No
242423981199.061.6330.8The free radical theory of aging matures. K B Beckman, B N AmesPhysiol Rev19989562038No
242511991199.036.3636.4Invasive aspergillosis. D W DenningClin Infect Dis19989564455No
242611991199.032.932.9The human orbitofrontal cortex: linking reward to hedonic experience. Morten L KringelbachNat Rev Neurosci200516136173No
242711991199.033.0533.0Reconciling the chemistry and biology of reactive oxygen species. Christine C WinterbournNat Chem Biol200818421291No
242835941198.063.9421.3A system for stable expression of short interfering RNAs in mammalian cells. Thijn R Brummelkamp, René Bernards, Reuven AgamiScience200211910072Yes
242911981198.033.5233.5Diagnosis of osteoporosis and assessment of fracture risk. John A KanisLancet200212057569No
243011981198.028.9829.0Mechanisms of foxp3+ T regulatory cell-mediated suppression. Ethan M ShevachImmunity200919464986No
2431131761197.8331.4330.1New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G GwytherJ Natl Cancer Inst200010655437No
243223951197.50.00.0Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. J E Sulston, H R HorvitzDev Biol1977838129Yes
243323941197.047.0323.5CpG islands in vertebrate genomes. M Gardiner-Garden, M FrommerJ Mol Biol19873656447Yes
243411971197.032.5632.6Low density lipoprotein oxidation and its pathobiological significance. D SteinbergJ Biol Chem19979261091No
243523941197.043.921.9The DNA damage response: putting checkpoints in perspective. B B Zhou, S J ElledgeNature200011100718No
243611961196.027.2127.2Hybridization of denatured RNA transferred or dotted nitrocellulose paper. P S ThomasMethods Enzymol19836194404Yes
243711951195.023.8423.8microRNAs: tiny regulators with great potential. V AmbrosCell200111779458No
243823891194.568.4534.2What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? K C Berridge, T E RobinsonBrain Res Brain Res Rev19989858756No
243923891194.580.0340.0Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. Johan W S Vlaeyen, Steven J LintonPain200010781906No
244023891194.562.2431.1Neuronal plasticity: increasing the gain in pain. C J Woolf, M W SalterScience200010846153No
244135831194.392.2330.7Long non-coding RNAs: insights into functions. Tim R Mercer, Marcel E Dinger, John S MattickNat Rev Genet200919188922No
244211941194.028.4128.4Growth factors and cancer. S A AaronsonScience19911659742No
244311941194.059.2359.2ROC methodology in radiologic imaging. C E MetzInvest Radiol19863095258No
244411941194.048.648.6Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. E H BeacheyJ Infect Dis19817014727No
244511941194.047.2647.3Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. T Florian JaegerJ Mem Lang200819884961Yes
244647751193.8217.3154.3Bayesian phylogenetics with BEAUti and the BEAST 1.7. Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew RambautMol Biol Evol201222367748Yes
244711931193.029.829.8Hereditary cancer, oncogenes, and antioncogenes. A G KnudsonCancer Res19852983882Yes
244823861193.075.2437.6CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. Mattias Jakobsson, Noah A RosenbergBioinformatics200717485429Yes
244923851192.547.6123.8Checkpoints: controls that ensure the order of cell cycle events. L H Hartwell, T A WeinertScience19892683079No
245023841192.054.2327.1The pathophysiology of mitochondrial cell death. Douglas R Green, Guido KroemerScience200415286356No
245111921192.037.137.1Multiple imputation of discrete and continuous data by fully conditional specification. Stef van BuurenStat Methods Med Res200717621469Yes
245211911191.034.8134.8Stress and depression. Constance HammenAnnu Rev Clin Psychol200517716090No
245335721190.788.6429.5Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Witold Filipowicz, Suvendra N Bhattacharyya, Nahum SonenbergNat Rev Genet200818197166No
245411901190.027.2627.3The stem-cell niche as an entity of action. David T ScaddenNature200616810242No
245523791189.561.3730.7Rising incidence of hepatocellular carcinoma in the United States. H B El-Serag, A C MasonN Engl J Med199910072408Yes
245611891189.029.2829.3Reactive oxygen radicals in signaling and damage in the ischemic brain. P H ChanJ Cereb Blood Flow Metab200111149664No
245723781189.082.9841.5Oxidative stress and diabetic complications. Ferdinando Giacco, Michael BrownleeCirc Res201021030723No
245847551188.8113.2428.3Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J ThunN Engl J Med200312711737Yes
245983171188.1348.1749.7Development and validation of a geriatric depression screening scale: a preliminary report. J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O LeirerJ Psychiatr Res19827183759Yes
246011881188.00.00.0Campylobacter enteritis: a "new" disease. M B SkirrowBr Med J1977871765Yes
246111881188.00.00.0Assay of intestinal disaccharidases. A DahlqvistAnal Biochem19685636962Yes
246211881188.026.2526.2The finer things in X-ray diffraction data collection. J W PflugrathActa Crystallogr D Biol Crystallogr199910531521Yes
246311881188.00.00.0The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. G A RoseBull World Health Organ196213974778Yes
246423751187.575.5237.8The benefits of being present: mindfulness and its role in psychological well-being. Kirk Warren Brown, Richard M RyanJ Pers Soc Psychol200312703651Yes
246523751187.567.934.0The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. W L Jorgensen, J Tirado-RivesJ Am Chem Soc198827557051Yes
246623741187.00.00.0Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. J D Peuler, G A JohnsonLife Sci1977904439Yes
246711871187.00.00.0Studies on phosphatidylcholine vesicles. Formation and physical characteristics. C HuangBiochemistry19695777332Yes
246823741187.064.4832.2Leukocyte-endothelial adhesion molecules. T M Carlos, J M HarlanBlood19947522621No
246923731186.575.837.9The cortical organization of speech processing. Gregory Hickok, David PoeppelNat Rev Neurosci200717431404No
247023721186.00.00.0Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Altman, G D DasJ Comp Neurol19655861717Yes
247111861186.045.7745.8Inflammation in atherosclerosis. Peter LibbyArterioscler Thromb Vasc Biol201222895665No
247223711185.545.2322.6DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Christopher J Bakkenist, Michael B KastanNature200312556884Yes
247323711185.564.9532.5Therapeutic potential of resveratrol: the in vivo evidence. Joseph A Baur, David A SinclairNat Rev Drug Discov200616732220No
247411851185.035.1135.1Atopic dermatitis. Thomas BieberN Engl J Med200818385500Yes
247571081184.7187.0831.2A default mode of brain function. M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L ShulmanProc Natl Acad Sci U S A200111209064Yes
247623681184.00.00.0Surgical risk as related to time of intervention in the repair of intracranial aneurysms. W E Hunt, R M HessJ Neurosurg19685635959Yes
247711841184.029.4129.4Somatostatin and its receptor family. Y C PatelFront Neuroendocrinol199910433861No
247811841184.034.1934.2The cancer stem cell: premises, promises and challenges. Hans CleversNat Med201121386835No
247923671183.554.7227.4Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. T Hunter, B M SeftonProc Natl Acad Sci U S A19806246487Yes
248023671183.564.0332.0Nanostructures in biodiagnostics. Nathaniel L Rosi, Chad A MirkinChem Rev200515826019No
248111831183.043.3943.4Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. R M PostAm J Psychiatry19921353322No
248211831183.045.3545.4Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. S H SafeCrit Rev Toxicol19948037844No
248311831183.038.538.5Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Thomas GrobnerNephrol Dial Transplant200616431890Yes
248411821182.028.728.7Intracellular protein topogenesis. G BlobelProc Natl Acad Sci U S A19806929499Yes
248511821182.00.00.0The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. W G DuncombeClin Chim Acta196414122498Yes
248611821182.00.00.0The cytoarchitectonic organization of the spinal cord in the cat. B RexedJ Comp Neurol195214946260Yes
248723621181.049.1824.6Gene silencing in cancer in association with promoter hypermethylation. James G Herman, Stephen B BaylinN Engl J Med200314627790No
248823611180.5187.293.6Natural Products as Sources of New Drugs from 1981 to 2014. David J Newman, Gordon M CraggJ Nat Prod201626852623No
248911801180.042.9643.0Multimodal approach to control postoperative pathophysiology and rehabilitation. H KehletBr J Anaesth19979175983No
249023601180.073.6936.8Mediation in experimental and nonexperimental studies: new procedures and recommendations. Patrick E Shrout, Niall BolgerPsychol Methods200212530702Yes
249111801180.030.4730.5The blood-brain barrier: bottleneck in brain drug development. William M PardridgeNeuroRx200515717053No
249211801180.00.00.0A new readability yardstick. R FleschJ Appl Psychol194818867058Yes
249311791179.037.9938.0The pathogenesis of sepsis. R C BoneAnn Intern Med19911872494No
249423581179.074.5837.3Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. D Filmer, L H PritchettDemography200111227840Yes
249523581179.069.0734.5Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Robert E W Hancock, Hans-Georg SahlNat Biotechnol200617160061No
249623571178.5118.2559.1A new initiative on precision medicine. Francis S Collins, Harold VarmusN Engl J Med201525635347Yes
249711781178.025.2725.3Caspase structure, proteolytic substrates, and function during apoptotic cell death. D W NicholsonCell Death Differ199910578171No
249811781178.021.3221.3Cancer susceptibility and the functions of BRCA1 and BRCA2. Ashok R VenkitaramanCell200211832208No
249911781178.053.0153.0MorphoJ: an integrated software package for geometric morphometrics. Christian Peter KlingenbergMol Ecol Resour201121429143Yes
250023551177.545.822.9The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. T Maehama, J E DixonJ Biol Chem19989593664Yes
250135321177.388.6129.5Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Christopher R Genovese, Nicole A Lazar, Thomas NicholsNeuroimage200211906227Yes
250211771177.066.2266.2Psychosocial resilience and protective mechanisms. Michael RutterAm J Orthopsychiatry19873303954No
250311771177.056.2256.2A cognitive approach to panic. D M ClarkBehav Res Ther19863741311Yes
250411771177.00.00.0Displaced proximal humeral fractures. I. Classification and evaluation. C S NeerJ Bone Joint Surg Am19705455339Yes
2505164671176.2365.2326.1Crystallography & NMR system: A new software suite for macromolecular structure determination. A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L WarrenActa Crystallogr D Biol Crystallogr19989757107Yes
250623511175.556.8728.4Peroxisome proliferator-activated receptors: nuclear control of metabolism. B Desvergne, W WahliEndocr Rev199910529898No
250711751175.030.6230.6Surrogate endpoints in clinical trials: definition and operational criteria. R L PrenticeStat Med19892727467Yes
250811751175.024.5924.6Morphogenetic roles of classic cadherins. M TakeichiCurr Opin Cell Biol19958573335No
250911751175.061.5661.6Optical properties of biological tissues: a review. Steven L JacquesPhys Med Biol201323666068No
251035231174.385.2928.4Dystrophin: the protein product of the Duchenne muscular dystrophy locus. E P Hoffman, R H Brown, L M KunkelCell19873319190Yes
251111741174.039.7839.8Interleukin-1 and the pathogenesis of the acute-phase response. C A DinarelloN Engl J Med19846208485No
251211741174.029.8529.9The neuropathology of schizophrenia. A critical review of the data and their interpretation. P J HarrisonBrain199910219775No
251323481174.087.3143.7How useful is SBF in predicting in vivo bone bioactivity? Tadashi Kokubo, Hiroaki TakadamaBiomaterials200616448693No
251411741174.033.0633.1Microbial influences in inflammatory bowel diseases. R Balfour SartorGastroenterology200818242222No
251523461173.00.00.0Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. R W Butcher, E W SutherlandJ Biol Chem196213875173Yes
251611721172.033.733.7Emotion regulation: affective, cognitive, and social consequences. James J GrossPsychophysiology200212212647No
251711721172.00.00.0A sensitive method for the assay of 5-hydroxytryptamine. J R VaneBr J Pharmacol Chemother195713460242Yes
251811721172.028.9228.9The path to ubiquitous and low-cost organic electronic appliances on plastic. Stephen R ForrestNature200415118718Yes
251911711171.037.6937.7Antioxidants in human health and disease. B HalliwellAnnu Rev Nutr19968839918No
252011711171.031.3331.3Drug delivery and targeting. R LangerNature19989579855No
252111711171.00.00.0A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. J B BrownBiochem J195514389222Yes
252211711171.028.5228.5Oxidative stress in neurodegeneration: cause or consequence? Julie K AndersenNat Med200415298006No
252311711171.00.00.0Histological demonstration of mucin after periodic acid. J F A McMANUSNature194620995486Yes
252470241170.7179.7430.0GROMACS: fast, flexible, and free. David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C BerendsenJ Comput Chem200516211538Yes
252535111170.3118.2539.4Simultaneous inference in general parametric models. Torsten Hothorn, Frank Bretz, Peter WestfallBiom J200818481363No
252611701170.00.00.0Nontuberculous mycobacteria and associated diseases. E WolinskyAm Rev Respir Dis1979369415No
252711701170.036.2836.3The mysteries of lipoprotein(a). G UtermannScience19892530631No
252811701170.034.8134.8Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. W SieghartPharmacol Rev19957568326No
252911701170.029.2129.2Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. P KuzmicAnal Biochem19968660575Yes
253035081169.386.1628.7Global and societal implications of the diabetes epidemic. P Zimmet, K G Alberti, J ShawNature200111742409No
253111691169.036.7136.7Biosynthesis and metabolism of endothelium-derived nitric oxide. L J IgnarroAnnu Rev Pharmacol Toxicol19902188578No
253211691169.040.8740.9The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. N M KaplanArch Intern Med19892662932No
253311691169.026.0626.1The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. S J CollinsBlood19873311197No
253435071169.0102.3934.1Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. H King, R E Aubert, W H HermanDiabetes Care19989727886Yes
253511691169.032.3832.4Plasmonics: merging photonics and electronics at nanoscale dimensions. Ekmel OzbayScience200616410515Yes
253635051168.3122.7140.9Factor structure of the Barratt impulsiveness scale. J H Patton, M S Stanford, E S BarrattJ Clin Psychol19958778124Yes
253735051168.374.1124.7Large-scale analysis of the yeast proteome by multidimensional protein identification technology. M P Washburn, D Wolters, J R YatesNat Biotechnol200111231557Yes
253811681168.00.00.0Measurement of feelings using visual analogue scales. R C AitkenProc R Soc Med19694899510No
253923361168.0122.5261.3A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. M Roland, R MorrisSpine (Phila Pa 1976)19836222486Yes
254011681168.022.0422.0Kinesin and dynein superfamily proteins and the mechanism of organelle transport. N HirokawaScience19989438838No
254111681168.026.4726.5Prediction of protein cellular attributes using pseudo-amino acid composition. K C ChouProteins200111288174Yes
254211671167.052.7252.7Presynaptic regulation of the release of catecholamines. S Z LangerPharmacol Rev19806267618Yes
254311671167.036.4736.5Depression in late life: review and commentary. Dan G BlazerJ Gerontol A Biol Sci Med Sci200312634292No
2544104991166.6358.0139.8A novel potent vasoconstrictor peptide produced by vascular endothelial cells. M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T MasakiNature19882451132Yes
254593331166.6244.4330.6Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M JoliotNeuroimage200211771995Yes
254634991166.386.6228.9Functional diversity of helper T lymphocytes. A K Abbas, K M Murphy, A SherNature19968893001No
254711661166.044.544.5A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. S T TiffanyPsychol Rev19902186423No
254811661166.026.5926.6S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. R DonatoInt J Biochem Cell Biol200111390274No
254946641166.0110.1227.5A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry SharplessAngew Chem Int Ed Engl200212203546Yes
255011661166.021.7121.7The molecular motor toolbox for intracellular transport. Ronald D ValeCell200312600311No
255111661166.027.5427.5Transcriptional control of adipocyte formation. Stephen R FarmerCell Metab200617011499No
255223311165.50.00.0The low-density lipoprotein pathway and its relation to atherosclerosis. J L Goldstein, M S BrownAnnu Rev Biochem1977197883No
255334951165.00.00.0Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. A DeLean, P J Munson, D RodbardAm J Physiol1978686171Yes
255411651165.053.0253.0Human agency in social cognitive theory. A BanduraAm Psychol19892782727Yes
255511651165.047.4247.4An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. J Kabat-ZinnGen Hosp Psychiatry19827042457Yes
255611651165.023.1423.1Mobile elements: drivers of genome evolution. Haig H KazazianScience200415016989No
255711651165.026.9226.9Nuclear factor-kappaB: the enemy within. Bharat B AggarwalCancer Cell200415380510No
255823291164.595.2447.6Rapid procedure for detection and isolation of large and small plasmids. C I Kado, S T LiuJ Bacteriol19817009583Yes
255958221164.4192.1938.4Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L WitztumN Engl J Med19892648148No
256034931164.3105.9335.3The functional anatomy of basal ganglia disorders. R L Albin, A B Young, J B PenneyTrends Neurosci19892479133No
256111641164.057.3757.4Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement. Virginia A MoyerAnn Intern Med201424378917No
256246541163.599.7524.9Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. D D Sarbassov, David A Guertin, Siraj M Ali, David M SabatiniScience200515718470Yes
256311631163.061.7261.7Rating scales to assess depression in school-aged children. M KovacsActa Paedopsychiatr19817025571Yes
256411631163.022.6122.6Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Ricky W JohnstoneNat Rev Drug Discov200212120280No
256523251162.550.5725.3ERBB receptors and cancer: the complexity of targeted inhibitors. Nancy E Hynes, Heidi A LaneNat Rev Cancer200515864276No
256611621162.049.449.4Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). S SafeCrit Rev Toxicol19902124811No
256723241162.063.7531.9Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. M A Pfeffer, E BraunwaldCirculation19902138525No
256834861162.00.00.0Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. A L Shapiro, E Viñuela, J V MaizelBiochem Biophys Res Commun19674861258Yes
256923241162.063.9932.0A review of central 5-HT receptors and their function. N M Barnes, T SharpNeuropharmacology199910462127No
257011621162.00.00.0An approximate distribution of estimates of variance components. F E SatterthwaiteBiometrics194620287815Yes
257134841161.390.6830.2Functional porous coordination polymers. Susumu Kitagawa, Ryo Kitaura, Shin-ichiro NoroAngew Chem Int Ed Engl200415114565Yes
257211611161.00.00.0Mutation selection and the natural history of cancer. J CairnsNature19751143315Yes
257311611161.00.00.0Diffusion-in-gel methods for immunological analysis. II. O OuchterlonyProg Allergy196214482809Yes
257411591159.00.00.0Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. M M WeiserJ Biol Chem19734698230Yes
257511591159.019.7119.7Themes and variations on ubiquitylation. A M WeissmanNat Rev Mol Cell Biol200111265246No
257611591159.054.6854.7Selenium and human health. Margaret P RaymanLancet201222381456No
257711581158.022.2122.2Contingent genetic regulatory events in T lymphocyte activation. G R CrabtreeScience19892783497Yes
257823151157.559.5429.8Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Kornelia Polyak, Robert A WeinbergNat Rev Cancer200919262571No
257911571157.00.00.0Presynaptic regulation of catecholamine release. S Z LangerBiochem Pharmacol19744617579No
258011571157.027.7227.7Liver fibrosis -- from bench to bedside. Scott L FriedmanJ Hepatol200312591185No
258111571157.028.0528.1DNA damage, aging, and cancer. Jan H J HoeijmakersN Engl J Med200919812404No
258223131156.564.3332.2ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. Markus Wiederstein, Manfred J SipplNucleic Acids Res200717517781Yes
258334691156.372.6624.2Cellular survival: a play in three Akts. S R Datta, A Brunet, M E GreenbergGenes Dev199910579998No
258411561156.074.1574.2Impingement lesions. C S NeerClin Orthop Relat Res19836825348Yes
258523111155.565.7532.9Antibiotic resistance of bacteria in biofilms. P S Stewart, J W CostertonLancet200111463434No
258634661155.396.932.3Molecular characterization of a peripheral receptor for cannabinoids. S Munro, K L Thomas, M Abu-ShaarNature19937689702Yes
258711551155.00.00.0Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J O HolloszyJ Biol Chem19674290225Yes
258811551155.041.0741.1Inhibition and facilitation of nucleic acid amplification. I G WilsonAppl Environ Microbiol19979327537No
258911551155.026.7826.8Long-term potentiation and memory. M A LynchPhysiol Rev200414715912No
259069281154.7135.9622.7Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T TuschlNature200111373684Yes
259123091154.549.3724.7A general framework for weighted gene co-expression network analysis. Bin Zhang, Steve HorvathStat Appl Genet Mol Biol200516646834Yes
259211541154.053.4653.5Biomaterial-centered infection: microbial adhesion versus tissue integration. A G GristinaScience19873629258Yes
259323081154.00.00.0Plasminogen: purification from human plasma by affinity chromatography. D G Deutsch, E T MertzScience19705475635Yes
259411541154.00.00.0RNA metabolism in the HeLa cell nucleus. S PenmanJ Mol Biol19665961144Yes
259523061153.045.4522.7Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. C W Greider, E H BlackburnCell19853907856Yes
259611531153.045.1645.2Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. H V GelboinPhysiol Rev19807001511No
259711531153.053.7553.8Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. P de LevaJ Biomech19968872282Yes
259811531153.033.9333.9Varieties of impulsivity. J L EvendenPsychopharmacology (Berl)199910550486No
259911531153.027.7227.7The Unified Medical Language System (UMLS): integrating biomedical terminology. Olivier BodenreiderNucleic Acids Res200414681409Yes
260057641152.8112.3222.5Crystal structure of the nucleosome core particle at 2.8 A resolution. K Luger, A W Mäder, R K Richmond, D F Sargent, T J RichmondNature19979305837Yes
260169151152.5177.1629.5Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O LötvallNat Cell Biol200717486113Yes
260223051152.561.6430.8Regulation mechanisms and signaling pathways of autophagy. Congcong He, Daniel J KlionskyAnnu Rev Genet200919653858No
260334571152.30.00.0High resolution two-dimensional electrophoresis of basic as well as acidic proteins. P Z O'Farrell, H M Goodman, P H O'FarrellCell197723215Yes
260411521152.053.3753.4Derivation and validation of a short-form oral health impact profile. G D SladeCommunity Dent Oral Epidemiol19979332805Yes
260523041152.047.723.9Molecular chaperones in the cytosol: from nascent chain to folded protein. F Ulrich Hartl, Manajit Hayer-HartlScience200211884745No
260623031151.50.00.0Quantitative determination of serum triglycerides by the use of enzymes. G Bucolo, H DavidClin Chem19734703655Yes
260723031151.550.1925.1Tumorigenesis and the angiogenic switch. Gabriele Bergers, Laura E BenjaminNat Rev Cancer200312778130No
260834541151.394.0331.3Membrane lipids: where they are and how they behave. Gerrit van Meer, Dennis R Voelker, Gerald W FeigensonNat Rev Mol Cell Biol200818216768No
260911511151.00.00.0Selective coronary arteriography. I. A percutaneous transfemoral technic. M P JudkinsRadiology19676048074Yes
261011511151.059.1459.1The clinical application of the biopsychosocial model. G L EngelAm J Psychiatry19807369396Yes
261123021151.051.4225.7Lymphocyte homing and homeostasis. E C Butcher, L J PickerScience19968600538No
261211511151.028.1128.1Matrix proteoglycans: from molecular design to cellular function. R V IozzoAnnu Rev Biochem19989759499No
261311511151.023.3723.4Lipid rafts: elusive or illusive? Sean MunroCell200314622593No
261411511151.033.2933.3The sympathetic control of blood pressure. Patrice G GuyenetNat Rev Neurosci200616760914No
261523011150.562.8631.4Imaging cognition II: An empirical review of 275 PET and fMRI studies. R Cabeza, L NybergJ Cogn Neurosci200010769304No
261634511150.30.00.0The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. G Blessed, B E Tomlinson, M RothBr J Psychiatry19685662937Yes
261711501150.00.00.0A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. R D HotchkissArch Biochem194818921848Yes
261834491149.775.2525.1Calcium signalling: dynamics, homeostasis and remodelling. Michael J Berridge, Martin D Bootman, H Llewelyn RoderickNat Rev Mol Cell Biol200312838335No
261911491149.030.7530.8Pathogenesis of dengue: challenges to molecular biology. S B HalsteadScience19883277268No
262011491149.031.1531.1The lipocalin protein family: structure and function. D R FlowerBiochem J19968761444No
262111481148.025.925.9Cadherins: a molecular family important in selective cell-cell adhesion. M TakeichiAnnu Rev Biochem19902197976No
262211471147.00.00.0Biogenic amines and the states of sleep. M JouvetScience19694303225No
262334411147.088.5529.5LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. A C Wallace, R A Laskowski, J M ThorntonProtein Eng19957630882Yes
262411471147.030.1330.1Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. G BodenDiabetes19978971073No
262511471147.029.3729.4Optimal experimental design for event-related fMRI. A M DaleHum Brain Mapp199910524601Yes
262622921146.069.8434.9Recent advances in the phencyclidine model of schizophrenia. D C Javitt, S R ZukinAm J Psychiatry19911654746No
262711461146.045.4245.4Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. S KatzJ Am Geriatr Soc19836418786No
262811461146.026.726.7Diarylethenes for Memories and Switches. Masahiro IrieChem Rev200011777416Yes
262911451145.00.00.0Radioimmunological determination of human C-peptide in serum. L G HedingDiabetologia19751239396Yes
263011451145.021.0421.0Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. D HanahanNature19852986015Yes
263111451145.030.7930.8Psychological and neural mechanisms of the affective dimension of pain. D D PriceScience200010846154No
2632183051144.1693.6643.4Fiji: an open-source platform for biological-image analysis. Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert CardonaNat Methods201222743772Yes
263311441144.00.00.0Experience from a multicentre stroke register: a preliminary report. S HatanoBull World Health Organ19761088404Yes
263411441144.00.00.0Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. D B ClewellJ Bacteriol19724336693Yes
263511441144.032.3932.4DNA topoisomerases. M GellertAnnu Rev Biochem19816267993No
263611441144.033.4433.4Papillary and follicular thyroid carcinoma. M J SchlumbergerN Engl J Med19989445411No
263711441144.038.2938.3The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Artemis P SimopoulosExp Biol Med (Maywood)200818408140No
263834311143.789.9830.0Atomic force microscope. Binnig, Quate, GerberPhys Rev Lett198610033323Yes
263922871143.50.00.0Growth of a rat neuroblastoma cell line in serum-free supplemented medium. J E Bottenstein, G H SatoProc Natl Acad Sci U S A1979284369Yes
264022871143.50.00.0Solubilization of membranes by detergents. A Helenius, K SimonsBiochim Biophys Acta19751091302No
264122861143.046.723.4A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. N C Andrews, D V FallerNucleic Acids Res19912041787Yes
264211431143.028.0528.1Pathways of oxidative damage. James A ImlayAnnu Rev Microbiol200314527285No
264322861143.062.0731.0Myocardial reperfusion injury. Derek M Yellon, Derek J HausenloyN Engl J Med200717855673No
264422861143.060.9430.5Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Uwe-Karsten Hanisch, Helmut KettenmannNat Neurosci200717965659No
264522851142.589.544.8Malondialdehyde determination as index of lipid peroxidation. H H Draper, M HadleyMethods Enzymol19902233309Yes
264634271142.30.00.0Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. G M Wahl, M Stern, G R StarkProc Natl Acad Sci U S A1979291033Yes
264711421142.025.0125.0Platelets in atherothrombosis. Zaverio M RuggeriNat Med200212411949No
264822841142.054.3827.2Can the pharmaceutical industry reduce attrition rates? Ismail Kola, John LandisNat Rev Drug Discov200415286737No
264934251141.780.5326.8OrthoMCL: identification of ortholog groups for eukaryotic genomes. Li Li, Christian J Stoeckert, David S RoosGenome Res200312952885Yes
265011411141.00.00.0The concept of immunological surveillance. F M BurnetProg Exp Tumor Res19704921480No
265111411141.00.00.0A simple objective technique for measuring flexibility in thinking. E A BergJ Gen Psychol194818889466Yes
265211401140.037.1337.1Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. J J GrossJ Pers Soc Psychol19989457784Yes
265311401140.029.1429.1Primate anterior cingulate cortex: where motor control, drive and cognition interface. T PausNat Rev Neurosci200111389475No
265411401140.026.2826.3Gene finding in novel genomes. Ian KorfBMC Bioinformatics200415144565Yes
265511401140.00.00.0pA, a new scale for the measurement of drug antagonism. H O SchildBr J Pharmacol Chemother194720258355Yes
265611391139.027.7327.7Rapid and sensitive sequence comparison with FASTP and FASTA. W R PearsonMethods Enzymol19902156132Yes
265711391139.031.6331.6Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. U MitzdorfPhysiol Rev19853880898No
265834151138.375.1425.0Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Michael J Rust, Mark Bates, Xiaowei ZhuangNat Methods200616896339Yes
265945531138.2100.5825.1Interleukin-10 and the interleukin-10 receptor. K W Moore, R de Waal Malefyt, R L Coffman, A O'GarraAnnu Rev Immunol200111244051No
266045531138.2276.6669.2IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang MinhMol Biol Evol201525371430Yes
266122761138.095.9848.0Reading senseless sentences: brain potentials reflect semantic incongruity. M Kutas, S A HillyardScience19807350657Yes
266211381138.00.00.0Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. R J PenningtonBiochem J196113734134Yes
266334121137.30.00.0Cytochemical identification of monocytes and granulocytes. L T Yam, C Y Li, W H CrosbyAm J Clin Pathol19715549896Yes
266434121137.391.0530.3Wnt/beta-catenin signaling: components, mechanisms, and diseases. Bryan T MacDonald, Keiko Tamai, Xi HeDev Cell200919619488No
266511371137.00.00.0Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. S Z LangerBr J Pharmacol197720190No
266611371137.034.4134.4Effect of anoxia on ion distribution in the brain. A J HansenPhysiol Rev19853880896No
266711371137.00.00.0Pathologic anatomy of the pancreas in juvenile diabetes mellitus. W GeptsDiabetes19655318831Yes
266811371137.026.2226.2Translating cell biology into therapeutic advances in Alzheimer's disease. D J SelkoeNature199910392577No
266911371137.032.0732.1The biochemistry and medical significance of the flavonoids. Bent H HavsteenPharmacol Ther200212453566No
267011371137.00.00.0Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. A B StavitskyJ Immunol195413163409Yes
267122741137.064.8332.4Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Ajay Kumar Gupta, Mona GuptaBiomaterials200515626447No
267211361136.00.00.0An improved fluorometric assay for DNA. R T HinegardnerAnal Biochem19715544593Yes
267311361136.028.8928.9Huntington's disease. Francis O WalkerLancet200717240289No
267422711135.5156.8678.4Facial nerve grading system. J W House, D E BrackmannOtolaryngol Head Neck Surg19853921901Yes
267522711135.549.7524.9Functions of lipid rafts in biological membranes. D A Brown, E LondonAnnu Rev Cell Dev Biol19989891780No
267611351135.026.8326.8Mitochondrial transport of cations: channels, exchangers, and permeability transition. P BernardiPhysiol Rev199910508231No
267722701135.078.7539.4Quality control and preprocessing of metagenomic datasets. Robert Schmieder, Robert EdwardsBioinformatics201121278185Yes
267822691134.571.2935.6Role of oxidized low density lipoprotein in atherogenesis. J L Witztum, D SteinbergJ Clin Invest19911752940No
267922691134.559.1429.6Drug delivery systems: entering the mainstream. Theresa M Allen, Pieter R CullisScience200415031496Yes
268011341134.035.7835.8Chronic disease management: what will it take to improve care for chronic illness? E H WagnerEff Clin Pract199810345255No
268111331133.00.00.0Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. A R MidgleyEndocrinology19665950482Yes
268211331133.025.7725.8Molecular physiology of low-voltage-activated t-type calcium channels. Edward Perez-ReyesPhysiol Rev200312506128No
268322661133.059.8929.9Microenvironmental regulation of metastasis. Johanna A Joyce, Jeffrey W PollardNat Rev Cancer200919279573No
268411321132.019.7719.8Mitotic kinases as regulators of cell division and its checkpoints. E A NiggNat Rev Mol Cell Biol200111413462No
268511321132.037.9638.0Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Charles A DinarelloBlood201121304099No
268622631131.561.8330.9Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. R A Ignotz, J MassaguéJ Biol Chem19863456347Yes
268722631131.596.7848.4Van der Waals heterostructures. A K Geim, I V GrigorievaNature201323887427Yes
268811311131.020.620.6Stem cells: units of development, units of regeneration, and units in evolution. I L WeissmanCell200010647940No
268911301130.028.7728.8Two distinct classes of carbohydrate-recognition domains in animal lectins. K DrickamerJ Biol Chem19883290208No
269011301130.043.4143.4On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. D CollenThromb Haemost19806450468No
269111301130.022.3522.4Mechanisms and consequences of activation of protein kinase B/Akt. J DownwardCurr Opin Cell Biol19989561851No
269222601130.062.2131.1Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. S Schulman, C KearonJ Thromb Haemost200515842354Yes
269311301130.025.2725.3The roles of intracellular protein-degradation pathways in neurodegeneration. David C RubinszteinNature200617051204No
269411291129.035.4835.5Protein damage and degradation by oxygen radicals. I. general aspects. K J DaviesJ Biol Chem19873036875Yes
269522581129.066.1133.1Increasing incidence of thyroid cancer in the United States, 1973-2002. Louise Davies, H Gilbert WelchJAMA200616684987Yes
269633841128.068.8623.0Predicting coiled coils from protein sequences. A Lupas, M Van Dyke, J StockScience19912031185Yes
269711281128.023.3723.4IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Yong-Jun LiuAnnu Rev Immunol200515771572No
269811271127.00.00.0Optimal foraging, the marginal value theorem. E L CharnovTheor Popul Biol19761273796Yes
269911271127.026.8626.9Brain tumors. L M DeAngelisN Engl J Med200111150363No
270033811127.0101.3833.8Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Günter Oberdörster, Eva Oberdörster, Jan OberdörsterEnviron Health Perspect200516002369No
270111271127.00.00.0The generalisation of student's problems when several different population variances are involved. B L WelchBiometrika194720287819Yes
270222531126.50.00.0Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. R B Gustilo, J T AndersonJ Bone Joint Surg Am1976773941Yes
270322531126.548.4724.2Toll-like receptors in the induction of the innate immune response. A Aderem, R J UlevitchNature200010963608No
270433791126.385.1428.4Tissue cells feel and respond to the stiffness of their substrate. Dennis E Discher, Paul Janmey, Yu-Li WangScience200516293750No
270545051126.2112.3928.1Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. H Nielsen, J Engelbrecht, S Brunak, G von HeijneProtein Eng19979051728Yes
270611261126.028.9228.9Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. I J FidlerCancer Res19901698118Yes
270711261126.033.9534.0Unstable angina. A classification. E BraunwaldCirculation19892752565Yes
270811261126.040.9841.0Plasma perspective on strong field multiphoton ionization. CorkumPhys Rev Lett199310054556Yes
270911261126.044.3944.4Translating social ecological theory into guidelines for community health promotion. D StokolsAm J Health Promot199610159709No
271011261126.030.6630.7Pain and emotion interactions in subregions of the cingulate gyrus. Brent A VogtNat Rev Neurosci200515995724No
271111261126.032.3532.4How brains beware: neural mechanisms of emotional attention. Patrik VuilleumierTrends Cogn Sci200516289871Yes
271222511125.551.2225.6The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. P M Sharp, W H LiNucleic Acids Res19873547335Yes
271311251125.036.4436.4Molecular biology of steroid hormone synthesis. W L MillerEndocr Rev19883061784No
271422501125.00.00.0Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. J D McGhee, P H von HippelJ Mol Biol19744416620Yes
271511251125.024.5124.5Stem cells in the central nervous system. R McKayScience19979082987No
271611251125.037.037.0Endometriosis. Serdar E BulunN Engl J Med200919144942No
271733741124.799.933.3Nitric oxide and peroxynitrite in health and disease. Pál Pacher, Joseph S Beckman, Lucas LiaudetPhysiol Rev200717237348No
271844981124.5124.8131.2Microbial ecology: human gut microbes associated with obesity. Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I GordonNature200617183309Yes
271922481124.00.00.0Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. L M Siegel, K J MontyBiochim Biophys Acta19665329026Yes
272011241124.034.8834.9Low-molecular-weight heparins. J I WeitzN Engl J Med19979278467No
272122481124.080.8140.4Oncology meets immunology: the cancer-immunity cycle. Daniel S Chen, Ira MellmanImmunity201323890059No
272222471123.50.00.0Radiological demarcation of cemented sockets in total hip replacement. J G DeLee, J CharnleyClin Orthop Relat Res1976991504Yes
272322471123.561.1230.6Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. M J Casadaban, S N CohenJ Mol Biol19806997493Yes
272411231123.033.9333.9Determinants of tumor blood flow: a review. R K JainCancer Res19883282647No
272511231123.030.3130.3The chromosomal basis of human neoplasia. J J YunisScience19836336310Yes
272611231123.022.4522.4Regulation of transcription by MAP kinase cascades. R TreismanCurr Opin Cell Biol19968791420No
272711231123.027.2427.2Metastatic bone disease: clinical features, pathophysiology and treatment strategies. R E ColemanCancer Treat Rev200111417967No
272822451122.543.9422.0Multiple nuclear factors interact with the immunoglobulin enhancer sequences. R Sen, D BaltimoreCell19863091258Yes
272922451122.566.4533.2Excitatory amino acids as a final common pathway for neurologic disorders. S A Lipton, P A RosenbergN Engl J Med19947905600No
273011221122.00.00.0An approach for the treatment of penile carcinoma. R M CabanasCancer1977837331Yes
273111221122.032.0232.0The induction of pain: an integrative review. M J MillanProg Neurobiol19999987804No
273211221122.031.2931.3Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Earl S FordDiabetes Care200515983333No
273322431121.591.7645.9The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. R Näätänen, T PictonPsychophysiology19873615753Yes
273422431121.50.00.0Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. H H Ussing, K ZerahnActa Physiol Scand195114868510Yes
273511211121.039.6339.6Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. A J AlpertJ Chromatogr19902324207Yes
273611211121.078.6278.6The problem of rigor in qualitative research. M SandelowskiANS Adv Nurs Sci19863083765Yes
273733631121.072.4324.1Toll-like receptors: critical proteins linking innate and acquired immunity. S Akira, K Takeda, T KaishoNat Immunol200111477402No
273833631121.0124.7441.6Rehospitalizations among patients in the Medicare fee-for-service program. Stephen F Jencks, Mark V Williams, Eric A ColemanN Engl J Med200919339721Yes
273922401120.075.8237.9Atomic structure and chemistry of human serum albumin. X M He, D C CarterNature19921630489Yes
274011201120.040.7840.8Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. W A CatterallAnnu Rev Pharmacol Toxicol19806247957No
274111201120.026.7726.8Amyloid, the presenilins and Alzheimer's disease. J HardyTrends Neurosci19979106355No
274211201120.00.00.0On the law of effect. R J HerrnsteinJ Exp Anal Behav197016811440Yes
274311201120.025.4225.4Solving structures of protein complexes by molecular replacement with Phaser. Airlie J McCoyActa Crystallogr D Biol Crystallogr200717164524Yes
274433601120.0107.6235.9Dose translation from animal to human studies revisited. Shannon Reagan-Shaw, Minakshi Nihal, Nihal AhmadFASEB J200817942826Yes
274544791119.8108.3827.1Base-calling of automated sequencer traces using phred. I. Accuracy assessment. B Ewing, L Hillier, M C Wendl, P GreenGenome Res19989521921Yes
274622391119.563.6331.8Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. R G Phillips, J E LeDouxBehav Neurosci19921590953Yes
274722391119.565.9333.0Alternative activation of macrophages: mechanism and functions. Siamon Gordon, Fernando O MartinezImmunity201020510870No
274844771119.2132.1733.0Place navigation impaired in rats with hippocampal lesions. R G Morris, P Garrud, J N Rawlins, J O'KeefeNature19827088155Yes
274911191119.035.1835.2Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. E N BergmanPhysiol Rev19902181501No
275011191119.033.0433.0Cell surface interactions with extracellular materials. K M YamadaAnnu Rev Biochem19836351729No
275111191119.030.8430.8Polymer conjugates as anticancer nanomedicines. Ruth DuncanNat Rev Cancer200616900224No
275222381119.062.931.4Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. Gerard Talavera, Jose CastresanaSyst Biol200717654362Yes
275311191119.028.7728.8Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. Christof M NiemeyerAngew Chem Int Ed Engl200129712109No
275422371118.50.00.0Construct validity in psychological tests. L J Cronbach, P E MeehlPsychol Bull195513245896Yes
275533541118.069.423.1The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Fabio Martinon, Kimberly Burns, Jürg TschoppMol Cell200212191486Yes
275644691117.2105.2226.3SCOP: a structural classification of proteins database for the investigation of sequences and structures. A G Murzin, S E Brenner, T Hubbard, C ChothiaJ Mol Biol19957723011Yes
275711171117.030.9831.0Diseases of the mitochondrial DNA. D C WallaceAnnu Rev Biochem19921497308No
275811171117.031.3931.4Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. G L SemenzaOncogene201019946328No
275933501116.787.4829.2Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. C R Woese, O Kandler, M L WheelisProc Natl Acad Sci U S A19902112744Yes
276044641116.0101.8425.5Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. J E Walker, M Saraste, M J Runswick, N J GayEMBO J19826329717Yes
276111161116.026.6626.7Allelic discrimination using fluorogenic probes and the 5' nuclease assay. K J LivakGenet Anal199910084106Yes
2762122601114.5443.1540.3A new equation to estimate glomerular filtration rate. Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef CoreshAnn Intern Med200919414839Yes
276311141114.023.823.8Mutator phenotype may be required for multistage carcinogenesis. L A LoebCancer Res19912039987No
276411141114.00.00.0Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J AltmanJ Comp Neurol19695361244Yes
276522271113.566.933.5Nitric oxide synthases in mammals. R G Knowles, S MoncadaBiochem J19947510950No
276611131113.033.9934.0The structure of common mental disorders. R F KruegerArch Gen Psychiatry199910530634Yes
276711131113.033.6633.7Reducing children's television viewing to prevent obesity: a randomized controlled trial. T N RobinsonJAMA199910546696Yes
276822251112.561.8430.9Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Barry J Everitt, Trevor W RobbinsNat Neurosci200516251991No
276922251112.591.6645.8Neutrophil recruitment and function in health and inflammation. Elzbieta Kolaczkowska, Paul KubesNat Rev Immunol201323435331No
277011121112.00.00.0Cytoprotection by prostaglandins. A RobertGastroenterology197938173Yes
277111121112.00.00.0Metabolic stability and epigenesis in randomly constructed genetic nets. S A KauffmanJ Theor Biol19695803332Yes
277233361112.078.2626.1Hepatocellular carcinoma. Josep M Llovet, Andrew Burroughs, Jordi BruixLancet200314667750No
277311111111.00.00.06-Hydroxy-dopamine induced degeneration of central monoamine neurons. U UngerstedtEur J Pharmacol19685718510Yes
277411111111.00.00.0Studies on histones. 7. Preparative methods for histone fractions from calf thymus. E W JohnsBiochem J19645840387Yes
277511111111.036.336.3Risk and maintenance factors for eating pathology: a meta-analytic review. Eric SticePsychol Bull200212206196No
277611111111.023.4823.5Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. Harold F DvorakJ Clin Oncol200212409337No
277711111111.030.5930.6Hydrogen sulphide and its therapeutic potential. Csaba SzabóNat Rev Drug Discov200717948022No
277811111111.025.5825.6Neuroligins and neurexins link synaptic function to cognitive disease. Thomas C SüdhofNature200818923512No
277911101110.030.1430.1Wound healing and its impairment in the diabetic foot. Vincent FalangaLancet200516291068No
278011101110.031.431.4Plant productivity and environment. J S BoyerScience198217808529Yes
278122201110.0108.354.1ROS function in redox signaling and oxidative stress. Michael Schieber, Navdeep S ChandelCurr Biol201424845678No
278211091109.028.8728.9Linkage strategies for genetically complex traits. I. Multilocus models. N RischAm J Hum Genet19902301392Yes
278311091109.025.4625.5Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. M KozakNucleic Acids Res19817301588Yes
278422181109.044.3322.2NF-kappaB at the crossroads of life and death. Michael Karin, Anning LinNat Immunol200211875461No
278511091109.025.2125.2Microglia as a source and target of cytokines. Uwe-Karsten HanischGlia200212379902No
278622181109.00.00.0Micromethod for the direct determination of serum triglycerides. E Van Handel, D B ZilversmitJ Lab Clin Med195713439279Yes
278711091109.00.00.0The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. R E Hope-SimpsonProc R Soc Med196514267505Yes
278822181109.051.0425.5Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Eugenia E Calle, Rudolf KaaksNat Rev Cancer200415286738No
278911091109.035.5435.5Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. Felix KratzJ Control Release200818582981No
279066531108.8179.6429.9Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat RoblesBioinformatics200516081474Yes
279111081108.021.1821.2Luciferase reporter gene vectors for analysis of promoters and enhancers. S K NordeenBiotechniques19882908509Yes
279211081108.026.7726.8Production of recombinant protein therapeutics in cultivated mammalian cells. Florian M WurmNat Biotechnol200415529164No
279311081108.034.8934.9Cytokinesis-block micronucleus cytome assay. Michael FenechNat Protoc200717546000Yes
279422131106.548.1524.1Atherosclerosis. the road ahead. C K Glass, J L WitztumCell200111239408No
279511061106.00.00.0Structure of chromatin. R D KornbergAnnu Rev Biochem1977332067No
279611061106.026.6826.7The prefrontal cortex and cognitive control. E K MillerNat Rev Neurosci200011252769No
279722111105.549.2224.6Prediction of protein secondary structure at better than 70% accuracy. B Rost, C SanderJ Mol Biol19938345525Yes
279811051105.035.4735.5Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J E OesterlingJ Urol19911707989No
279911051105.040.0740.1The LMS method for constructing normalized growth standards. T J ColeEur J Clin Nutr19902354692Yes
280022101105.041.1720.6Stats: transcriptional control and biological impact. David E Levy, J E DarnellNat Rev Mol Cell Biol200212209125No
280111051105.00.00.0Voluntary strength and fatigue. P A MertonJ Physiol195413152698Yes
280211051105.00.00.0Preliminary Trial Of Carisoprodol In Multiple Sclerosis. B AshworthPractitioner196414143329Yes
280322101105.052.0626.0Toll-like receptors in innate immunity. Kiyoshi Takeda, Shizuo AkiraInt Immunol200515585605No
280422091104.5141.3970.7A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. E S Grood, W J SuntayJ Biomech Eng19836865355Yes
280522091104.50.00.0Microdroplet Assay Of Human Serum Cytotoxins. P I Terasaki, J D McclellandNature196414248725Yes
280622091104.50.00.0A revision of the Schoenheimer-Sperry method for cholesterol determination. W M Sperry, M WebbJ Biol Chem195014794694Yes
280711041104.031.2531.2Normalization of cell responses in cat striate cortex. D J HeegerVis Neurosci19921504027Yes
280811041104.031.031.0Neural simulation of action: a unifying mechanism for motor cognition. M JeannerodNeuroimage200111373140No
280922071103.543.8221.9Homeobox genes and axial patterning. W McGinnis, R KrumlaufCell19921346368No
281011031103.023.5923.6ALSCRIPT: a tool to format multiple sequence alignments. G J BartonProtein Eng19938433969Yes
281122061103.072.8336.4An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. O Johnell, J A KanisOsteoporos Int200616983459Yes
281222051102.567.7433.9A cognitive model of posttraumatic stress disorder. A Ehlers, D M ClarkBehav Res Ther200010761279No
281311021102.037.6937.7Chemoprevention of cancer. L W WattenbergCancer Res19853880665No
281411021102.024.9424.9Physiological concentrations of purines and pyrimidines. T W TrautMol Cell Biochem19947877593No
281511021102.022.0122.0Microarray data normalization and transformation. John QuackenbushNat Genet200212454644No
281677141102.0288.3541.2GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J SchünemannBMJ200818436948Yes
281711011101.043.4543.5Molecular aspects of ligand binding to serum albumin. U Kragh-HansenPharmacol Rev19817027277No
281811011101.00.00.0The powerful placebo. H K BeecherJ Am Med Assoc195513271123Yes
281911011101.030.4530.4Q-ball imaging. David S TuchMagn Reson Med200415562495Yes
282011011101.025.7925.8Recognition and processing of ubiquitin-protein conjugates by the proteasome. Daniel FinleyAnnu Rev Biochem200919489727No
282177041100.6258.1336.9AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J OlsonJ Comput Chem200919399780Yes
282222011100.545.8522.9Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. G A Gonzalez, M R MontminyCell19892573431Yes
282333011100.30.00.0Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. M Hamberg, J Svensson, B SamuelssonProc Natl Acad Sci U S A19751059088Yes
282411001100.00.00.0Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units. C M VenkatachalamBiopolymers19685685102Yes
282511001100.027.627.6Metabolism and functions of glutathione in brain. R DringenProg Neurobiol200010880854No
282611001100.025.6725.7Neurobiology of Pavlovian fear conditioning. S MarenAnnu Rev Neurosci200111520922No
282711001100.036.7636.8Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Ronald A HitesEnviron Sci Technol200414998004Yes
282821991099.564.4632.2The cognitive control of emotion. Kevin N Ochsner, James J GrossTrends Cogn Sci200515866151No
282921981099.00.00.0Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. R J Britten, D E KohneScience19684874239Yes
283065941099.0229.6538.3The occurrence of sleep-disordered breathing among middle-aged adults. T Young, M Palta, J Dempsey, J Skatrud, S Weber, S BadrN Engl J Med19938464434Yes
283110991099.023.4923.5Basement membranes: structure, assembly and role in tumour angiogenesis. Raghu KalluriNat Rev Cancer200312778132No
283221971098.50.00.0Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. A H Coons, M H KaplanJ Exp Med195015395569Yes
283376891098.4160.6522.9Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P SpeedBiostatistics200312925520Yes
283421961098.050.3425.2Adaptive protein evolution at the Adh locus in Drosophila. J H McDonald, M KreitmanNature19911904993Yes
283510981098.044.4544.5Social phobia. M R LiebowitzMod Probl Pharmacopsychiatry19872885745Yes
283610981098.00.00.0The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion. S RosemanChem Phys Lipids19705476326Yes
283710981098.023.0823.1Differentiation and proliferation of hematopoietic stem cells. M OgawaBlood19938499622No
283810981098.029.1729.2Neural systems for recognizing emotion. Ralph AdolphsCurr Opin Neurobiol200212015233No
283910981098.00.00.0Inherited Antithrombin Deficiency Causing Thrombophilia. O EgebergThromb Diath Haemorrh196514347873Yes
284021951097.50.00.0Construction of phylogenetic trees. W M Fitch, E MargoliashScience19675334057No
284121951097.571.9236.0Excitatory amino acid transmitters. J C Watkins, R H EvansAnnu Rev Pharmacol Toxicol19816112965No
284221951097.570.2335.1Natural products as sources of new drugs over the last 25 years. David J Newman, Gordon M CraggJ Nat Prod200717309302No
284310971097.0104.22104.2The analysis of errors in orthodontic measurements. W J HoustonAm J Orthod19836573846Yes
284421941097.053.2226.6Emerging roles of caspase-3 in apoptosis. A G Porter, R U JänickeCell Death Differ199910200555No
284510971097.030.8930.9Leishmaniasis. B L HerwaldtLancet199910513726No
284610971097.00.00.0A cytoarchitectonic atlas of the spinal cord in the cat. B RexedJ Comp Neurol195413163236Yes
284710971097.034.234.2High prevalence of vitamin D inadequacy and implications for health. Michael F HolickMayo Clin Proc200616529140No
284821941097.063.4631.7Meeting of minds: the medial frontal cortex and social cognition. David M Amodio, Chris D FrithNat Rev Neurosci200616552413No
284910971097.00.00.0Knee joint changes after meniscectomy. T J FairbankJ Bone Joint Surg Br194818894618Yes
285010961096.00.00.0Sex-hormone-binding globulin. D C AndersonClin Endocrinol (Oxf)19744134992No
285110961096.024.8124.8The molecular biology of leukocyte chemoattractant receptors. P M MurphyAnnu Rev Immunol19948011292No
285221921096.045.622.8An automated method for finding molecular complexes in large protein interaction networks. Gary D Bader, Christopher W V HogueBMC Bioinformatics200312525261Yes
285310961096.036.5636.6Delirium in older persons. Sharon K InouyeN Engl J Med200616540616No
285443821095.5121.0930.3Prevalence and trends in obesity among US adults, 1999-2000. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L JohnsonJAMA200212365955Yes
285510951095.022.3222.3Primary response genes induced by growth factors and tumor promoters. H R HerschmanAnnu Rev Biochem19911883198No
285610951095.030.9731.0Internal models for motor control and trajectory planning. M KawatoCurr Opin Neurobiol199910607637No
285721901095.061.4430.7Epidemiology and outcomes of osteoporotic fractures. Steven R Cummings, L Joseph MeltonLancet200212049882No
285821891094.596.2848.1Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. P R Hunter, M A GastonJ Clin Microbiol19883069867Yes
285910931093.037.3537.4Selective attention and the organization of visual information. J DuncanJ Exp Psychol Gen19846240521Yes
286010931093.00.00.0Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins. R D OwenScience194517755278Yes
286110931093.028.8528.9Non-Smad pathways in TGF-beta signaling. Ying E ZhangCell Res200919114990No
286210931093.038.8138.8Breakthrough of the year 2013. Cancer immunotherapy. Jennifer Couzin-FrankelScience201324357284No
286321861093.096.6948.3The future of immune checkpoint therapy. Padmanee Sharma, James P AllisonScience201525838373No
286410921092.041.4841.5Omega-3 fatty acids in health and disease and in growth and development. A P SimopoulosAm J Clin Nutr19911908631No
286510921092.046.2246.2A cochlear frequency-position function for several species--29 years later. D D GreenwoodJ Acoust Soc Am19902373794Yes
286610921092.057.1357.1Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. Anna Maria CarlssonPain19836602967Yes
286721841092.044.2922.1Proliferation, cell cycle and apoptosis in cancer. G I Evan, K H VousdenNature200111357141No
286810921092.030.5330.5Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Paul WillnerNeuropsychobiology200516037678No
286910911091.039.4239.4Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. J N WasserheitSex Transm Dis19921595015No
287010911091.041.9942.0The role of endothelium in the responses of vascular smooth muscle to drugs. R F FurchgottAnnu Rev Pharmacol Toxicol19846203480No
287110911091.029.5729.6The neurobiology of stress: from serendipity to clinical relevance. B S McEwenBrain Res200011119695No
287210911091.00.00.0Intra-sexual selection in Drosophila. A J BatemanHeredity (Edinb)194818103134Yes
287321821091.095.1447.6Neoantigens in cancer immunotherapy. Ton N Schumacher, Robert D SchreiberScience201525838375No
287410901090.021.3321.3Regulation of phosphoinositide-specific phospholipase C. S G RheeAnnu Rev Biochem200111395409No
287510901090.00.00.0The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. J VagueAm J Clin Nutr195613282851Yes
287610901090.00.00.0Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. R M BerneAm J Physiol196313971060Yes
287710901090.031.9832.0Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Antoine BecharaNat Neurosci200516251988No
287821791089.597.3448.7The M1 and M2 paradigm of macrophage activation: time for reassessment. Fernando O Martinez, Siamon GordonF1000Prime Rep201424669294No
287910891089.041.0541.0The P300 wave of the human event-related potential. T W PictonJ Clin Neurophysiol19921464675No
288010891089.023.1123.1A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. J MilbrandtScience19873672127Yes
288110891089.045.3145.3Bone "mass" and the "mechanostat": a proposal. H M FrostAnat Rec19873688455Yes
288210891089.023.1123.1Apoptosis in neurodegenerative disorders. M P MattsonNat Rev Mol Cell Biol200011253364No
288310891089.00.00.0The purine and pyrimidine composition of deoxypentose nucleic acids. G R WyattBiochem J195114838906Yes
288421771088.562.8331.4Ageing and Parkinson's disease: substantia nigra regional selectivity. J M Fearnley, A J LeesBrain19911933245Yes
288510881088.022.9923.0T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. R H SchwartzAnnu Rev Immunol19852415139No
288654401088.0189.9238.0Posttraumatic stress disorder in the National Comorbidity Survey. R C Kessler, A Sonnega, E Bromet, M Hughes, C B NelsonArch Gen Psychiatry19957492257Yes
288710881088.030.8330.8Physiology and pathophysiology of purinergic neurotransmission. Geoffrey BurnstockPhysiol Rev200717429044No
288843501087.5157.1139.3Guidelines for the process of cross-cultural adaptation of self-report measures. D E Beaton, C Bombardier, F Guillemin, M B FerrazSpine (Phila Pa 1976)200011124735No
288921741087.040.8520.4Hedgehog signaling in animal development: paradigms and principles. P W Ingham, A P McMahonGenes Dev200111731473No
289010871087.030.8830.9Mitochondrial fusion and fission in cell life and death. Benedikt WestermannNat Rev Mol Cell Biol201021102612No
289121731086.576.9438.5The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. G P Chrousos, P W GoldJAMA19921538563No
289221731086.547.5523.8The mammalian unfolded protein response. Martin Schröder, Randal J KaufmanAnnu Rev Biochem200515952902No
289332591086.371.9324.0A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. M Serrano, G J Hannon, D BeachNature19938259215Yes
289443451086.2104.126.0Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. G L Wang, B H Jiang, E A Rue, G L SemenzaProc Natl Acad Sci U S A19957539918Yes
289510861086.021.7721.8Cytokine receptor signalling. J N IhleNature19957566171No
289610861086.028.528.5Overview of general physiologic features and functions of vitamin D. Hector F DeLucaAm J Clin Nutr200415585789No
289721721086.062.1431.1A neurotrophic model for stress-related mood disorders. Ronald S Duman, Lisa M MonteggiaBiol Psychiatry200616631126No
289810861086.025.8225.8Human natural killer cells. Michael A CaligiuriBlood200818650461No
289921721086.073.9537.0Accessories to the crime: functions of cells recruited to the tumor microenvironment. Douglas Hanahan, Lisa M CoussensCancer Cell201222439926No
290010861086.036.9537.0Mitochondria and cancer. Douglas C WallaceNat Rev Cancer201223001348No
290110861086.066.2266.2The brain's default mode network. Marcus E RaichleAnnu Rev Neurosci201525938726No
290210851085.00.00.0Corticosteroids and lymphoid cells. H N ClamanN Engl J Med19725043524Yes
290310851085.030.830.8Pharmacology of cannabinoid CB1 and CB2 receptors. R G PertweePharmacol Ther19979336020No
290410851085.027.727.7Optical microcavities. Kerry J VahalaNature200312917698Yes
290510851085.00.00.0The relation of the trail making test to organic brain damage. R M ReitanJ Consult Psychol195513263471Yes
290610851085.00.00.0A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. M G BuonocoreJ Dent Res195513271655Yes
290721701085.047.6923.8NF-kappaB: linking inflammation and immunity to cancer development and progression. Michael Karin, Florian R GretenNat Rev Immunol200516175180No
290810841084.023.8523.9An overview of epithelio-mesenchymal transformation. E D HayActa Anat (Basel)19958714286No
290932501083.3140.6646.9Multiple imputation using chained equations: Issues and guidance for practice. Ian R White, Patrick Royston, Angela M WoodStat Med201121225900Yes
291010831083.00.00.0Aniline hydrogen phthalate as a spraying reagent for chromatography of sugars. S M PartridgeNature194918140444Yes
291143301082.5110.527.6Autophagy fights disease through cellular self-digestion. Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J KlionskyNature200818305538No
291210821082.027.8227.8Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. M J BerridgeBiochem J19836309155Yes
291310821082.00.00.0Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. P B MedawarBr J Exp Pathol194818865105Yes
291410811081.00.00.0A kinetic photometric method for serum gamma-glutamyl transpeptidase. G SzaszClin Chem19695773262Yes
291510811081.032.2732.3Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. M J GassonJ Bacteriol19836403500Yes
291610811081.031.7331.7The effects of stressful life events on depression. R C KesslerAnnu Rev Psychol19979046559No
291710811081.030.3930.4Venous thrombosis: a multicausal disease. F R RosendaalLancet199910209995No
291821601080.081.9941.0Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. H Esterbauer, K H CheesemanMethods Enzymol19902233308Yes
291910801080.046.0546.0A spreading-activation theory of retrieval in sentence production. G S DellPsychol Rev19863749399Yes
292010801080.00.00.0The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs. M VogtJ Physiol195413152692Yes
292110801080.027.4127.4Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. R Balfour SartorNat Clin Pract Gastroenterol Hepatol200616819502No
292221591079.543.721.9RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. M B Shapiro, P SenapathyNucleic Acids Res19873658675Yes
292321591079.545.8722.9p53: puzzle and paradigm. L J Ko, C PrivesGenes Dev19968654922No
292421591079.552.6326.3Cellular processing of platinum anticancer drugs. Dong Wang, Stephen J LippardNat Rev Drug Discov200515789122No
292510791079.032.1332.1The fetal and infant origins of adult disease. D J BarkerBMJ19902252919No
292621581079.055.1327.6C-reactive protein: a critical update. Mark B Pepys, Gideon M HirschfieldJ Clin Invest200312813013No
292710791079.033.4233.4Water as an active constituent in cell biology. Philip BallChem Rev200818095715No
292821571078.541.6520.8Dynamic instability of microtubule growth. T Mitchison, M KirschnerNature19846504138Yes
292932351078.3104.7234.9MR diffusion tensor spectroscopy and imaging. P J Basser, J Mattiello, D LeBihanBiophys J19948130344Yes
293010781078.00.00.0Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. K SatohClin Chim Acta1978719890Yes
293110781078.022.0722.1A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. Xuemei ChenScience200412893888Yes
293210781078.00.00.0Cleavage of the haem-protein link by acid methylethylketone. F W TealeBiochim Biophys Acta195913837237Yes
293310781078.040.3640.4The amazing osteocyte. Lynda F BonewaldJ Bone Miner Res201121254230No
293410771077.034.334.3The oxidation hypothesis of atherosclerosis. J L WitztumLancet19947916078No
293510771077.033.7333.7Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. M E BoutonPsychol Bull19938346330No
293610761076.041.9942.0A new international staging system for lung cancer. C F MountainChest19863514171No
293710761076.00.00.0A teacher rating scale for use in drug studies with children. C K ConnersAm J Psychiatry19694900822Yes
293810761076.00.00.0Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities. F FonnumBiochem J19694982085Yes
293910761076.022.4822.5Inferences, questions and possibilities in Toll-like receptor signalling. Bruce BeutlerNature200415241424No
294032271075.7107.7135.9Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. B K Matuszewski, M L Constanzer, C M Chavez-EngAnal Chem200312964746Yes
294121511075.50.00.0Peroxidase-labeled antibody. A new method of conjugation. P K Nakane, A KawaoiJ Histochem Cytochem19744443551Yes
294221511075.568.7634.4Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. S Geman, D GemanIEEE Trans Pattern Anal Mach Intell198422499653Yes
294310751075.025.9225.9Molecular drive: a cohesive mode of species evolution. G DoverNature19827110332Yes
294410751075.034.0834.1Strategies of antioxidant defense. H SiesEur J Biochem19937688300No
294521481074.00.00.0Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. A Warshel, M LevittJ Mol Biol1976985660Yes
294610741074.030.8130.8Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. T FeiziNature19852579340Yes
294710741074.020.2920.3The development of neural stem cells. S TempleNature200111689956No
294821471073.558.0329.0Oxidative stress, caloric restriction, and aging. R S Sohal, R WeindruchScience19968658196No
294910731073.037.7237.7Multiple organ failure. Pathophysiology and potential future therapy. E A DeitchAnn Surg19921503516No
295010731073.00.00.0Asymptomatic infections of the urinary tract. E H KassTrans Assoc Am Physicians195613380946Yes
295164361072.7141.9223.7Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. D A Melton, P A Krieg, M R Rebagliati, T Maniatis, K Zinn, M R GreenNucleic Acids Res19846091052Yes
295221451072.566.3533.22,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. A Poland, J C KnutsonAnnu Rev Pharmacol Toxicol19826282188No
295310721072.027.5927.6Selectins: interpreters of cell-specific carbohydrate information during inflammation. L A LaskyScience19921439808No
295410721072.032.6632.7A human model of gastric carcinogenesis. P CorreaCancer Res19883288329No
295510721072.032.3532.4Cholesterol and the cell membrane. P L YeagleBiochim Biophys Acta19853904832No
295621441072.052.0626.0Quorum sensing in bacteria. M B Miller, B L BasslerAnnu Rev Microbiol200111544353No
295710721072.059.5459.5Nonalcoholic fatty liver disease: a systematic review. Mary E RinellaJAMA201526057287No
295842871071.8129.6632.4Toxic potential of materials at the nanolevel. Andre Nel, Tian Xia, Lutz Mädler, Ning LiScience200616456071No
295921421071.047.7323.9Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. T Hunter, J PinesCell19947954824No
296021421071.070.9635.5Modeling and comparison of dissolution profiles. P Costa, J M Sousa LoboEur J Pharm Sci200111297896No
296110711071.00.00.0A New Serum Type System In Man--The Lp System. K BergActa Pathol Microbiol Scand196314064818Yes
296210701070.025.2425.2Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. S H KaufmannCancer Res19892790800Yes
296310701070.043.8443.8Freezing of living cells: mechanisms and implications. P MazurAm J Physiol19846383068No
296410701070.025.2525.2Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. H J DargieLancet200111356434Yes
296521401070.00.00.0Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques. P Gold, S O FreedmanJ Exp Med196514270243Yes
296610701070.029.6629.7Functionalized acenes and heteroacenes for organic electronics. John E AnthonyChem Rev200617165682Yes
296710701070.061.3661.4Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. Kevin A HallgrenTutor Quant Methods Psychol201222833776Yes
296896261069.6674.7275.0Cancer statistics in China, 2015. Wanqing Chen, Rongshou Zheng, Peter D Baade, Siwei Zhang, Hongmei Zeng, Freddie Bray, Ahmedin Jemal, Xue Qin Yu, Jie HeCA Cancer J Clin201626808342Yes
296921391069.574.5237.3Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. A E Czeizel, I DudásN Engl J Med19921307234Yes
297010691069.032.8532.9What is synergy? M C BerenbaumPharmacol Rev19892692037No
297110691069.027.0527.1The Trk family of neurotrophin receptors. M BarbacidJ Neurobiol19947852993No
297210691069.037.2337.2beta-Lactamases in laboratory and clinical resistance. D M LivermoreClin Microbiol Rev19958665470No
297310691069.023.6823.7PHD: predicting one-dimensional protein structure by profile-based neural networks. B RostMethods Enzymol19968743704Yes
297410691069.028.5728.6Disorders of iron metabolism. N C AndrewsN Engl J Med199910607817No
297510691069.021.5621.6Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. A S BaldwinJ Clin Invest200111160144No
297621381069.071.3735.7Chronic hepatitis B: update 2009. Anna S F Lok, Brian J McMahonHepatology200919714720Yes
297721371068.548.3924.2Cell cycle control and cancer. L H Hartwell, M B KastanScience19947997877No
297821361068.00.00.0T antigen is bound to a host protein in SV40-transformed cells. D P Lane, L V CrawfordNature1979218111Yes
297910681068.027.1527.1Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Hiroshi TakayanagiNat Rev Immunol200717380158No
298021351067.50.00.0Binding of soluble form of fibroblast surface protein, fibronectin, to collagen. E Engvall, E RuoslahtiInt J Cancer1977903179Yes
298121351067.564.0332.0Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. P Brugada, J BrugadaJ Am Coll Cardiol19921309182Yes
298221351067.568.5334.3Glutamate and the pathophysiology of hypoxic--ischemic brain damage. S M Rothman, J W OlneyAnn Neurol19862421636No
298310671067.031.231.2A Wilcoxon-type test for trend. J CuzickStat Med19853992076Yes
298410671067.029.7529.8Aging, energy, and oxidative stress in neurodegenerative diseases. M F BealAnn Neurol19957668820No
298510671067.025.2625.3Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. Michael J SandersonMol Biol Evol200211752195Yes
298610671067.041.1941.2The role of autophagy in neurodegenerative disease. Ralph A NixonNat Med201323921753No
298710661066.00.00.0A comparison of canal preparations in straight and curved root canals. S W SchneiderOral Surg Oral Med Oral Pathol19715284110Yes
298831971065.773.8724.6Adjusting batch effects in microarray expression data using empirical Bayes methods. W Evan Johnson, Cheng Li, Ariel RabinovicBiostatistics200716632515Yes
298942621065.587.8122.0Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. L Alexopoulou, A C Holt, R Medzhitov, R A FlavellNature2001