Unicorn Papers - Top cited papers from PUBMED

No.	Citations	EC_cit	RCR	EC_RCR	Title	Authors	Journal	Year	PMID	Article(?)
1	221093	221093.0	0.0	0.0	Cleavage of structural proteins during the assembly of the head of bacteriophage T4.	U K Laemmli	Nature	1970	5432063	Yes
2	167829	167829.0	0.0	0.0	A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.	M M Bradford	Anal Biochem	1976	942051	Yes
3	287785	71946.2	0.0	0.0	Protein measurement with the Folin phenol reagent.	O H Lowry, N J Rosebrough, A L Farr, R J Randall	J Biol Chem	1951	14907713	Yes
4	93271	46635.5	2411.62	1205.8	Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.	K J Livak, T D Schmittgen	Methods	2001	11846609	Yes
5	42746	42746.0	1460.76	1460.8	A short history of SHELX.	George M Sheldrick	Acta Crystallogr A	2008	18156677	Yes
6	33235	33235.0	1076.48	1076.5	Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.	T Mosmann	J Immunol Methods	1983	6606682	Yes
7	65216	32608.0	1977.38	988.7	Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.	P Chomczynski, N Sacchi	Anal Biochem	1987	2440339	Yes
8	30157	30157.0	0.0	0.0	Detection of specific sequences among DNA fragments separated by gel electrophoresis.	E M Southern	J Mol Biol	1975	1195397	Yes
9	25017	25017.0	0.0	0.0	The assessment and analysis of handedness: the Edinburgh inventory.	R C Oldfield	Neuropsychologia	1971	5146491	Yes
10	24455	24455.0	570.03	570.0	MicroRNAs: genomics, biogenesis, mechanism, and function.	David P Bartel	Cell	2004	14744438	No
11	23322	23322.0	0.0	0.0	A rating scale for depression.	M Hamilton	J Neurol Neurosurg Psychiatry	1960	14399272	Yes
12	22030	22030.0	691.46	691.5	Confidence Limits On Phylogenies: An Approach Using The Bootstrap.	Joseph Felsenstein	Evolution	1985	28561359	Yes
13	65251	21750.3	0.0	0.0	DNA sequencing with chain-terminating inhibitors.	F Sanger, S Nicklen, A R Coulson	Proc Natl Acad Sci U S A	1977	271968	Yes
14	21058	21058.0	503.7	503.7	A new mathematical model for relative quantification in real-time RT-PCR.	M W Pfaffl	Nucleic Acids Res	2001	11328886	Yes
15	21005	21005.0	526.87	526.9	MUSCLE: multiple sequence alignment with high accuracy and high throughput.	Robert C Edgar	Nucleic Acids Res	2004	15034147	Yes
16	19898	19898.0	0.0	0.0	The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.	E S Reynolds	J Cell Biol	1963	13986422	Yes
17	59379	19793.0	0.0	0.0	"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician.	M F Folstein, S E Folstein, P R McHugh	J Psychiatr Res	1975	1202204	Yes
18	36349	18174.5	1126.75	563.4	The neighbor-joining method: a new method for reconstructing phylogenetic trees.	N Saitou, M Nei	Mol Biol Evol	1987	3447015	Yes
19	17911	17911.0	0.0	0.0	Tissue sulfhydryl groups.	G L Ellman	Arch Biochem Biophys	1959	13650640	Yes
20	53093	17697.7	0.0	0.0	Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.	H Towbin, T Staehelin, J Gordon	Proc Natl Acad Sci U S A	1979	388439	Yes
21	16826	16826.0	0.0	0.0	Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins.	B J Davis	Ann N Y Acad Sci	1964	14240539	Yes
22	16665	16665.0	0.0	0.0	High resolution two-dimensional electrophoresis of proteins.	P H O'Farrell	J Biol Chem	1975	236308	Yes
23	33198	16599.0	1612.33	806.2	Statistical methods for assessing agreement between two methods of clinical measurement.	J M Bland, D G Altman	Lancet	1986	2868172	Yes
24	16230	16230.0	577.95	578.0	Density-functional exchange-energy approximation with correct asymptotic behavior.	Becke	Phys Rev A Gen Phys	1988	9900728	Yes
25	15986	15986.0	419.26	419.3	Atherosclerosis--an inflammatory disease.	R Ross	N Engl J Med	1999	9887164	No
26	15901	15901.0	0.0	0.0	A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.	K Burton	Biochem J	1956	13293190	Yes
27	31213	15606.5	1133.12	566.6	Hallmarks of cancer: the next generation.	Douglas Hanahan, Robert A Weinberg	Cell	2011	21376230	No
28	30369	15184.5	0.0	0.0	A rapid method of total lipid extraction and purification.	E G Bligh, W J Dyer	Can J Biochem Physiol	1959	13671378	Yes
29	15113	15113.0	563.15	563.1	A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences.	M Kimura	J Mol Evol	1980	7463489	Yes
30	28894	14447.0	0.0	0.0	The measurement of observer agreement for categorical data.	J R Landis, G G Koch	Biometrics	1977	843571	Yes
31	43088	14362.7	1245.49	415.2	CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.	J D Thompson, D G Higgins, T J Gibson	Nucleic Acids Res	1994	7984417	Yes
32	41537	13845.7	0.0	0.0	A simple method for the isolation and purification of total lipides from animal tissues.	J Folch, M Lees, G H Sloane Stanley	J Biol Chem	1957	13428781	Yes
33	13191	13191.0	368.42	368.4	MicroRNAs: target recognition and regulatory functions.	David P Bartel	Cell	2009	19167326	No
34	12801	12801.0	0.0	0.0	Phosphorus assay in column chromatography.	G R Bartlett	J Biol Chem	1959	13641241	Yes
35	12714	12714.0	540.99	541.0	A power primer.	J Cohen	Psychol Bull	1992	19565683	Yes
36	25122	12561.0	972.17	486.1	Meta-analysis in clinical trials.	R DerSimonian, N Laird	Control Clin Trials	1986	3802833	Yes
37	12324	12324.0	368.79	368.8	Projector augmented-wave method.	Blöchl	Phys Rev B Condens Matter	1994	9976227	Yes
38	24478	12239.0	1023.88	511.9	The hospital anxiety and depression scale.	A S Zigmond, R P Snaith	Acta Psychiatr Scand	1983	6880820	Yes
39	11790	11790.0	469.12	469.1	Catalase in vitro.	H Aebi	Methods Enzymol	1984	6727660	Yes
40	11000	11000.0	596.52	596.5	RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies.	Alexandros Stamatakis	Bioinformatics	2014	24451623	Yes
41	21904	10952.0	933.99	467.0	The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection.	J E Ware, C D Sherbourne	Med Care	1992	1593914	Yes
42	54626	10925.2	1581.11	316.2	Basic local alignment search tool.	S F Altschul, W Gish, W Miller, E W Myers, D J Lipman	J Mol Biol	1990	2231712	Yes
43	21558	10779.0	559.74	279.9	A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.	A P Feinberg, B Vogelstein	Anal Biochem	1983	6312838	Yes
44	21196	10598.0	472.67	236.3	Coot: model-building tools for molecular graphics.	Paul Emsley, Kevin Cowtan	Acta Crystallogr D Biol Crystallogr	2004	15572765	Yes
45	31775	10591.7	995.26	331.8	Generalized Gradient Approximation Made Simple.	Perdew, Burke, Ernzerhof	Phys Rev Lett	1996	10062328	Yes
46	10306	10306.0	0.0	0.0	Improvements in epoxy resin embedding methods.	J H Luft	J Biophys Biochem Cytol	1961	13764136	Yes
47	10227	10227.0	346.38	346.4	Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS).	J F Kurtzke	Neurology	1983	6685237	Yes
48	20101	10050.5	0.0	0.0	The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.	K Weber, M Osborn	J Biol Chem	1969	5806584	Yes
49	10012	10012.0	398.75	398.8	Structure validation in chemical crystallography.	Anthony L Spek	Acta Crystallogr D Biol Crystallogr	2009	19171970	Yes
50	19885	9942.5	561.73	280.9	Fast and accurate short read alignment with Burrows-Wheeler transform.	Heng Li, Richard Durbin	Bioinformatics	2009	19451168	Yes
51	9892	9892.0	0.0	0.0	The genetics of Caenorhabditis elegans.	S Brenner	Genetics	1974	4366476	Yes
52	29473	9824.3	1081.0	360.3	Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density.	Lee, Yang, Parr	Phys Rev B Condens Matter	1988	9944570	Yes
53	9791	9791.0	304.68	304.7	The Psychophysics Toolbox.	D H Brainard	Spat Vis	1997	9176952	Yes
54	19510	9755.0	441.79	220.9	[20] Processing of X-ray diffraction data collected in oscillation mode.	Zbyszek Otwinowski, Wladek Minor	Methods Enzymol	1997	27799103	Yes
55	9581	9581.0	358.37	358.4	Search and clustering orders of magnitude faster than BLAST.	Robert C Edgar	Bioinformatics	2010	20709691	Yes
56	9464	9464.0	0.0	0.0	Self-efficacy: toward a unifying theory of behavioral change.	A Bandura	Psychol Rev	1977	847061	Yes
57	9425	9425.0	324.73	324.7	Banting lecture 1988. Role of insulin resistance in human disease.	G M Reaven	Diabetes	1988	3056758	No
58	9418	9418.0	277.15	277.1	Xds.	Wolfgang Kabsch	Acta Crystallogr D Biol Crystallogr	2010	20124692	Yes
59	9248	9248.0	268.88	268.9	Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.	P S Thomas	Proc Natl Acad Sci U S A	1980	6159641	Yes
60	18113	9056.5	680.84	340.4	Fast gapped-read alignment with Bowtie 2.	Ben Langmead, Steven L Salzberg	Nat Methods	2012	22388286	Yes
61	9037	9037.0	240.53	240.5	Studies on transformation of Escherichia coli with plasmids.	D Hanahan	J Mol Biol	1983	6345791	Yes
62	18063	9031.5	475.2	237.6	A simple method for displaying the hydropathic character of a protein.	J Kyte, R F Doolittle	J Mol Biol	1982	7108955	Yes
63	9022	9022.0	260.28	260.3	The pathogenesis of atherosclerosis: a perspective for the 1990s.	R Ross	Nature	1993	8479518	No
64	8965	8965.0	354.59	354.6	A new method for measuring daytime sleepiness: the Epworth sleepiness scale.	M W Johns	Sleep	1991	1798888	Yes
65	8918	8918.0	235.37	235.4	Integrins: versatility, modulation, and signaling in cell adhesion.	R O Hynes	Cell	1992	1555235	No
66	17804	8902.0	813.19	406.6	The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations.	R M Baron, D A Kenny	J Pers Soc Psychol	1986	3806354	Yes
67	8502	8502.0	600.94	600.9	Crystal structure refinement with SHELXL.	George M Sheldrick	Acta Crystallogr C Struct Chem	2015	25567568	Yes
68	16991	8495.5	485.69	242.8	Quantifying heterogeneity in a meta-analysis.	Julian P T Higgins, Simon G Thompson	Stat Med	2002	12111919	Yes
69	8444	8444.0	187.07	187.1	Mfold web server for nucleic acid folding and hybridization prediction.	Michael Zuker	Nucleic Acids Res	2003	12824337	Yes
70	8327	8327.0	237.96	238.0	Evolutionary trees from DNA sequences: a maximum likelihood approach.	J Felsenstein	J Mol Evol	1981	7288891	Yes
71	8302	8302.0	231.95	231.9	RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models.	Alexandros Stamatakis	Bioinformatics	2006	16928733	Yes
72	8154	8154.0	0.0	0.0	On the origin of cancer cells.	O Warburg	Science	1956	13298683	Yes
73	8154	8154.0	259.68	259.7	Vitamin D deficiency.	Michael F Holick	N Engl J Med	2007	17634462	No
74	8046	8046.0	173.86	173.9	Linear models and empirical bayes methods for assessing differential expression in microarray experiments.	Gordon K Smyth	Stat Appl Genet Mol Biol	2004	16646809	Yes
75	16044	8022.0	353.07	176.5	The hallmarks of cancer.	D Hanahan, R A Weinberg	Cell	2000	10647931	No
76	7975	7975.0	0.0	0.0	Solvent content of protein crystals.	B W Matthews	J Mol Biol	1968	5700707	Yes
77	15934	7967.0	468.56	234.3	Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set.	Kresse, Furthmüller	Phys Rev B Condens Matter	1996	9984901	Yes
78	7863	7863.0	355.01	355.0	Psychophysical bases of perceived exertion.	G A Borg	Med Sci Sports Exerc	1982	7154893	Yes
79	23337	7779.0	625.59	208.5	VMD: visual molecular dynamics.	W Humphrey, A Dalke, K Schulten	J Mol Graph	1996	8744570	Yes
80	7761	7761.0	218.29	218.3	The role of protein kinase C in cell surface signal transduction and tumour promotion.	Y Nishizuka	Nature	1984	6232463	No
81	7729	7729.0	217.88	217.9	"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.	W N Burnette	Anal Biochem	1981	6266278	Yes
82	7666	7666.0	0.0	0.0	A simplification of the protein assay method of Lowry et al. which is more generally applicable.	G L Peterson	Anal Biochem	1977	603028	Yes
83	7653	7653.0	171.11	171.1	The functions of animal microRNAs.	Victor Ambros	Nature	2004	15372042	No
84	30529	7632.2	931.44	232.9	Measuring inconsistency in meta-analyses.	Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman	BMJ	2003	12958120	No
85	7566	7566.0	0.0	0.0	Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.	J R Vane	Nat New Biol	1971	5284360	Yes
86	7413	7413.0	0.0	0.0	Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris.	D I Arnon	Plant Physiol	1949	16654194	Yes
87	7340	7340.0	201.0	201.0	Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.	M C Hochberg	Arthritis Rheum	1997	9324032	Yes
88	14593	7296.5	348.07	174.0	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.	Kazutoshi Takahashi, Shinya Yamanaka	Cell	2006	16904174	Yes
89	7221	7221.0	0.0	0.0	A low-viscosity epoxy resin embedding medium for electron microscopy.	A R Spurr	J Ultrastruct Res	1969	4887011	Yes
90	7209	7209.0	213.6	213.6	Semiempirical GGA-type density functional constructed with a long-range dispersion correction.	Stefan Grimme	J Comput Chem	2006	16955487	Yes
91	28512	7128.0	1103.18	275.8	A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.	M E Charlson, P Pompei, K L Ales, C R MacKenzie	J Chronic Dis	1987	3558716	Yes
92	21156	7052.0	606.51	202.2	Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.	Da Wei Huang, Brad T Sherman, Richard A Lempicki	Nat Protoc	2009	19131956	Yes
93	7044	7044.0	0.0	0.0	Tumor angiogenesis: therapeutic implications.	J Folkman	N Engl J Med	1971	4938153	No
94	7026	7026.0	0.0	0.0	Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.	A Böyum	Scand J Clin Lab Invest Suppl	1968	4179068	Yes
95	6989	6989.0	194.08	194.1	TreeView: an application to display phylogenetic trees on personal computers.	R D Page	Comput Appl Biosci	1996	8902363	Yes
96	13964	6982.0	356.64	178.3	MrBayes 3: Bayesian phylogenetic inference under mixed models.	Fredrik Ronquist, John P Huelsenbeck	Bioinformatics	2003	12912839	Yes
97	20615	6871.7	0.0	0.0	Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.	W T Friedewald, R I Levy, D S Fredrickson	Clin Chem	1972	4337382	Yes
98	47892	6841.7	1271.3	181.6	Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.	S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J Lipman	Nucleic Acids Res	1997	9254694	No
99	6841	6841.0	0.0	0.0	The thiobarbituric acid assay of sialic acids.	L Warren	J Biol Chem	1959	13672998	Yes
100	27218	6804.5	1194.39	298.6	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	PLoS Med	2009	19621072	No
101	6751	6751.0	206.2	206.2	AFNI: software for analysis and visualization of functional magnetic resonance neuroimages.	R W Cox	Comput Biomed Res	1996	8812068	Yes
102	6731	6731.0	183.59	183.6	The steroid and thyroid hormone receptor superfamily.	R M Evans	Science	1988	3283939	No
103	20168	6722.7	576.84	192.3	A new generation of Ca2+ indicators with greatly improved fluorescence properties.	G Grynkiewicz, M Poenie, R Y Tsien	J Biol Chem	1985	3838314	Yes
104	13410	6705.0	0.0	0.0	Continuous cultures of fused cells secreting antibody of predefined specificity.	G Köhler, C Milstein	Nature	1975	1172191	Yes
105	26729	6682.2	896.38	224.1	Bias in meta-analysis detected by a simple, graphical test.	M Egger, G Davey Smith, M Schneider, C Minder	BMJ	1997	9310563	Yes
106	13252	6626.0	287.44	143.7	Processing of X-ray diffraction data collected in oscillation mode.	Z Otwinowski, W Minor	Methods Enzymol	1997	27754618	Yes
107	19855	6618.3	793.15	264.4	NIH Image to ImageJ: 25 years of image analysis.	Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri	Nat Methods	2012	22930834	No
108	6618	6618.0	154.68	154.7	Chromatin modifications and their function.	Tony Kouzarides	Cell	2007	17320507	No
109	13207	6603.5	382.3	191.2	Analyzing real-time PCR data by the comparative C(T) method.	Thomas D Schmittgen, Kenneth J Livak	Nat Protoc	2008	18546601	Yes
110	6592	6592.0	230.44	230.4	The blockade of immune checkpoints in cancer immunotherapy.	Drew M Pardoll	Nat Rev Cancer	2012	22437870	No
111	6581	6581.0	177.72	177.7	Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.	F Tajima	Genetics	1989	2513255	Yes
112	6508	6508.0	261.6	261.6	Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses.	Andreas Stang	Eur J Epidemiol	2010	20652370	Yes
113	6493	6493.0	170.95	170.9	PAML 4: phylogenetic analysis by maximum likelihood.	Ziheng Yang	Mol Biol Evol	2007	17483113	Yes
114	6486	6486.0	172.67	172.7	Adhesion receptors of the immune system.	T A Springer	Nature	1990	1974032	No
115	6477	6477.0	311.04	311.0	Comparative fit indexes in structural models.	P M Bentler	Psychol Bull	1990	2320703	Yes
116	6444	6444.0	177.56	177.6	Canonical dynamics: Equilibrium phase-space distributions.	Hoover	Phys Rev A Gen Phys	1985	9895674	Yes
117	12772	6386.0	295.98	148.0	Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana.	S J Clough, A F Bent	Plant J	1998	10069079	Yes
118	6356	6356.0	169.19	169.2	Angiogenesis in cancer, vascular, rheumatoid and other disease.	J Folkman	Nat Med	1995	7584949	No
119	6351	6351.0	129.77	129.8	Rapid and efficient site-specific mutagenesis without phenotypic selection.	T A Kunkel	Proc Natl Acad Sci U S A	1985	3881765	Yes
120	6331	6331.0	0.0	0.0	The assessment of anxiety states by rating.	M Hamilton	Br J Med Psychol	1959	13638508	Yes
121	12616	6308.0	0.0	0.0	Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.	Y Cheng, W H Prusoff	Biochem Pharmacol	1973	4202581	Yes
122	6290	6290.0	164.29	164.3	Fast robust automated brain extraction.	Stephen M Smith	Hum Brain Mapp	2002	12391568	No
123	18864	6288.0	857.81	285.9	Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.	Michael I Love, Wolfgang Huber, Simon Anders	Genome Biol	2014	25516281	Yes
124	6251	6251.0	213.55	213.6	Density-functional approximation for the correlation energy of the inhomogeneous electron gas.	Perdew	Phys Rev B Condens Matter	1986	9938299	Yes
125	12465	6232.5	0.0	0.0	Statistical aspects of the analysis of data from retrospective studies of disease.	N Mantel, W Haenszel	J Natl Cancer Inst	1959	13655060	Yes
126	6204	6204.0	193.17	193.2	The VideoToolbox software for visual psychophysics: transforming numbers into movies.	D G Pelli	Spat Vis	1997	9176953	Yes
127	6136	6136.0	204.72	204.7	Ethical guidelines for investigations of experimental pain in conscious animals.	Manfred Zimmermann	Pain	1983	6877845	No
128	6125	6125.0	135.77	135.8	p53, the cellular gatekeeper for growth and division.	A J Levine	Cell	1997	9039259	No
129	12183	6091.5	0.0	0.0	A rapid alkaline extraction procedure for screening recombinant plasmid DNA.	H C Birnboim, J Doly	Nucleic Acids Res	1979	388356	Yes
130	12031	6015.5	268.48	134.2	KEGG: kyoto encyclopedia of genes and genomes.	M Kanehisa, S Goto	Nucleic Acids Res	2000	10592173	Yes
131	6011	6011.0	150.41	150.4	Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm.	T A Springer	Cell	1994	7507411	No
132	6005	6005.0	172.6	172.6	Apoptosis: a review of programmed cell death.	Susan Elmore	Toxicol Pathol	2007	17562483	No
133	23976	5994.0	0.0	0.0	Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.	J M Chirgwin, A E Przybyla, R J MacDonald, W J Rutter	Biochemistry	1979	518835	Yes
134	5930	5930.0	152.28	152.3	Inositol trisphosphate and calcium signalling.	M J Berridge	Nature	1993	8381210	No
135	5908	5908.0	152.23	152.2	G proteins: transducers of receptor-generated signals.	A G Gilman	Annu Rev Biochem	1987	3113327	No
136	11801	5900.5	0.0	0.0	Prediction of creatinine clearance from serum creatinine.	D W Cockcroft, M H Gault	Nephron	1976	1244564	Yes
137	11765	5882.5	554.81	277.4	MAFFT multiple sequence alignment software version 7: improvements in performance and usability.	Kazutaka Katoh, Daron M Standley	Mol Biol Evol	2013	23329690	Yes
138	5802	5802.0	121.51	121.5	Integrins: bidirectional, allosteric signaling machines.	Richard O Hynes	Cell	2002	12297042	No
139	5797	5797.0	191.7	191.7	The Clinical Dementia Rating (CDR): current version and scoring rules.	J C Morris	Neurology	1993	8232972	Yes
140	5767	5767.0	133.35	133.3	Inflammation in atherosclerosis.	Peter Libby	Nature	2002	12490960	No
141	11493	5746.5	0.0	0.0	The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature.	T Omura, R Sato	J Biol Chem	1964	14209971	Yes
142	11431	5715.5	0.0	0.0	Intraclass correlations: uses in assessing rater reliability.	P E Shrout, J L Fleiss	Psychol Bull	1979	18839484	No
143	17111	5703.7	848.07	282.7	Trimmomatic: a flexible trimmer for Illumina sequence data.	Anthony M Bolger, Marc Lohse, Bjoern Usadel	Bioinformatics	2014	24695404	Yes
144	5669	5669.0	144.23	144.2	Inflammation, atherosclerosis, and coronary artery disease.	Göran K Hansson	N Engl J Med	2005	15843671	No
145	5634	5634.0	277.88	277.9	Investigation of the freely available easy-to-use software 'EZR' for medical statistics.	Y Kanda	Bone Marrow Transplant	2013	23208313	Yes
146	5622	5622.0	144.38	144.4	Apoptosis in the pathogenesis and treatment of disease.	C B Thompson	Science	1995	7878464	No
147	11199	5599.5	400.85	200.4	The meaning and use of the area under a receiver operating characteristic (ROC) curve.	J A Hanley, B J McNeil	Radiology	1982	7063747	Yes
148	5573	5573.0	138.58	138.6	Biochemistry and molecular cell biology of diabetic complications.	M Brownlee	Nature	2001	11742414	Yes
149	16702	5567.3	1362.36	454.1	MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets.	Sudhir Kumar, Glen Stecher, Koichiro Tamura	Mol Biol Evol	2016	27004904	Yes
150	5510	5510.0	0.0	0.0	A Self-Rating Depression Scale.	W W Zung	Arch Gen Psychiatry	1965	14221692	Yes
151	5470	5470.0	135.17	135.2	Free radicals in the physiological control of cell function.	Wulf Dröge	Physiol Rev	2002	11773609	No
152	10892	5446.0	252.18	126.1	Dendritic cells and the control of immunity.	J Banchereau, R M Steinman	Nature	1998	9521319	No
153	10883	5441.5	293.89	146.9	Sequencing end-labeled DNA with base-specific chemical cleavages.	A M Maxam, W Gilbert	Methods Enzymol	1980	6246368	Yes
154	10863	5431.5	0.0	0.0	A series of normal stages in the development of the chick embryo.	V Hamburger, H L Hamilton	J Morphol	1951	24539719	Yes
155	10819	5409.5	273.1	136.6	MRBAYES: Bayesian inference of phylogenetic trees.	J P Huelsenbeck, F Ronquist	Bioinformatics	2001	11524383	Yes
156	5403	5403.0	0.0	0.0	Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues.	F Tietze	Anal Biochem	1969	4388022	Yes
157	5361	5361.0	137.0	137.0	New M13 vectors for cloning.	J Messing	Methods Enzymol	1983	6310323	Yes
158	16063	5354.3	0.0	0.0	Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.	H Ohkawa, N Ohishi, K Yagi	Anal Biochem	1979	36810	Yes
159	5284	5284.0	0.0	0.0	Evaluation of survival data and two new rank order statistics arising in its consideration.	N Mantel	Cancer Chemother Rep	1966	5910392	Yes
160	5282	5282.0	104.7	104.7	BLAT--the BLAST-like alignment tool.	W James Kent	Genome Res	2002	11932250	Yes
161	5254	5254.0	128.37	128.4	Antimicrobial peptides of multicellular organisms.	Michael Zasloff	Nature	2002	11807545	Yes
162	5252	5252.0	152.97	153.0	Studies and perspectives of protein kinase C.	Y Nishizuka	Science	1986	3014651	No
163	5247	5247.0	0.0	0.0	Modification of seizure activity by electrical stimulation. II. Motor seizure.	R J Racine	Electroencephalogr Clin Neurophysiol	1972	4110397	Yes
164	5242	5242.0	118.87	118.9	The biochemistry of apoptosis.	M O Hengartner	Nature	2000	11048727	No
165	5233	5233.0	191.04	191.0	The Strengths and Difficulties Questionnaire: a research note.	R Goodman	J Child Psychol Psychiatry	1997	9255702	Yes
166	5233	5233.0	142.6	142.6	The Cambridge Structural Database: a quarter of a million crystal structures and rising.	Frank H Allen	Acta Crystallogr B	2002	12037359	Yes
167	5221	5221.0	0.0	0.0	[A micro-method of immuno-electrophoresis].	J J Scheidegger	Int Arch Allergy Appl Immunol	1955	13262900	Yes
168	10403	5201.5	300.63	150.3	MODELTEST: testing the model of DNA substitution.	D Posada, K A Crandall	Bioinformatics	1998	9918953	Yes
169	15581	5193.7	473.41	157.8	A simple salting out procedure for extracting DNA from human nucleated cells.	S A Miller, D D Dykes, H F Polesky	Nucleic Acids Res	1988	3344216	Yes
170	5175	5175.0	0.0	0.0	Selective extraction of polyoma DNA from infected mouse cell cultures.	B Hirt	J Mol Biol	1967	4291934	Yes
171	10346	5173.0	244.39	122.2	Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features.	W Kabsch, C Sander	Biopolymers	1983	6667333	Yes
172	15480	5160.0	508.87	169.6	Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.	Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien	Ann Surg	2004	15273542	Yes
173	5154	5154.0	190.32	190.3	Oxygen-derived free radicals in postischemic tissue injury.	J M McCord	N Engl J Med	1985	2981404	No
174	5109	5109.0	0.0	0.0	The Environment And Disease: Association Or Causation?	A B Hill	Proc R Soc Med	1965	14283879	Yes
175	10218	5109.0	250.61	125.3	A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood.	Stéphane Guindon, Olivier Gascuel	Syst Biol	2003	14530136	Yes
176	5101	5101.0	126.23	126.2	The NF-kappa B and I kappa B proteins: new discoveries and insights.	A S Baldwin	Annu Rev Immunol	1996	8717528	No
177	25422	5084.4	701.32	140.3	The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.	J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G Higgins	Nucleic Acids Res	1997	9396791	Yes
178	5083	5083.0	0.0	0.0	Mutation and cancer: statistical study of retinoblastoma.	A G Knudson	Proc Natl Acad Sci U S A	1971	5279523	Yes
179	10086	5043.0	374.0	187.0	The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.	R F Furchgott, J V Zawadzki	Nature	1980	6253831	Yes
180	10028	5014.0	267.66	133.8	Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa.	H Schägger, G von Jagow	Anal Biochem	1987	2449095	Yes
181	4997	4997.0	0.0	0.0	Aging: a theory based on free radical and radiation chemistry.	D Harman	J Gerontol	1956	13332224	Yes
182	4997	4997.0	174.8	174.8	jModelTest: phylogenetic model averaging.	David Posada	Mol Biol Evol	2008	18397919	Yes
183	4988	4988.0	130.73	130.7	Inflammation and metabolic disorders.	Gökhan S Hotamisligil	Nature	2006	17167474	No
184	4980	4980.0	0.0	0.0	A protein binding assay for adenosine 3':5'-cyclic monophosphate.	A G Gilman	Proc Natl Acad Sci U S A	1970	4318781	Yes
185	4976	4976.0	202.45	202.4	Orienting of attention.	M I Posner	Q J Exp Psychol	1980	7367577	Yes
186	9921	4960.5	228.22	114.1	One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.	K A Datsenko, B L Wanner	Proc Natl Acad Sci U S A	2000	10829079	Yes
187	4947	4947.0	183.34	183.3	Analyzing Tables Of Statistical Tests.	William R Rice	Evolution	1989	28568501	Yes
188	4946	4946.0	0.0	0.0	Development of a rating scale for primary depressive illness.	M Hamilton	Br J Soc Clin Psychol	1967	6080235	Yes
189	4943	4943.0	261.45	261.4	UPARSE: highly accurate OTU sequences from microbial amplicon reads.	Robert C Edgar	Nat Methods	2013	23955772	Yes
190	4939	4939.0	117.64	117.6	Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis.	J Castresana	Mol Biol Evol	2000	10742046	Yes
191	4935	4935.0	0.0	0.0	Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.	C B Laurell	Anal Biochem	1966	5959431	Yes
192	14793	4931.0	539.79	179.9	Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.	S M Hsu, L Raine, H Fanger	J Histochem Cytochem	1981	6166661	Yes
193	4931	4931.0	102.44	102.4	Rho GTPases and the actin cytoskeleton.	A Hall	Science	1998	9438836	No
194	9793	4896.5	356.94	178.5	Ligand: a versatile computerized approach for characterization of ligand-binding systems.	P J Munson, D Rodbard	Anal Biochem	1980	6254391	Yes
195	4884	4884.0	0.0	0.0	Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis.	M Rodbell	J Biol Chem	1964	14169133	Yes
196	14612	4870.7	440.05	146.7	edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.	Mark D Robinson, Davis J McCarthy, Gordon K Smyth	Bioinformatics	2010	19910308	Yes
197	9718	4859.0	276.31	138.2	Neuropathological stageing of Alzheimer-related changes.	H Braak, E Braak	Acta Neuropathol	1991	1759558	No
198	14491	4830.3	394.77	131.6	Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors.	C Yanisch-Perron, J Vieira, J Messing	Gene	1985	2985470	Yes
199	14473	4824.3	360.49	120.2	A comprehensive set of sequence analysis programs for the VAX.	J Devereux, P Haeberli, O Smithies	Nucleic Acids Res	1984	6546423	Yes
200	4824	4824.0	99.05	99.0	Epithelial-mesenchymal transitions in tumour progression.	Jean Paul Thiery	Nat Rev Cancer	2002	12189386	No
201	14424	4808.0	0.0	0.0	Determination of serum proteins by means of the biuret reaction.	A G Gornall, C J Bardawill, M M David	J Biol Chem	1949	18110453	Yes
202	9555	4777.5	0.0	0.0	A quantitative description of membrane current and its application to conduction and excitation in nerve.	A L Hodgkin, A F Huxley	J Physiol	1952	12991237	Yes
203	4770	4770.0	144.62	144.6	Developments of a water-maze procedure for studying spatial learning in the rat.	R Morris	J Neurosci Methods	1984	6471907	Yes
204	4767	4767.0	97.26	97.3	An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.	M Kozak	Nucleic Acids Res	1987	3313277	No
205	4767	4767.0	133.18	133.2	Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.	P Matsudaira	J Biol Chem	1987	3611052	Yes
206	9524	4762.0	352.0	176.0	Three approaches to qualitative content analysis.	Hsiu-Fang Hsieh, Sarah E Shannon	Qual Health Res	2005	16204405	Yes
207	14259	4753.0	445.52	148.5	The PHQ-9: validity of a brief depression severity measure.	K Kroenke, R L Spitzer, J B Williams	J Gen Intern Med	2001	11556941	Yes
208	9443	4721.5	0.0	0.0	A new technique for the assay of infectivity of human adenovirus 5 DNA.	F L Graham, A J van der Eb	Virology	1973	4705382	Yes
209	4700	4700.0	273.76	273.8	Prokka: rapid prokaryotic genome annotation.	Torsten Seemann	Bioinformatics	2014	24642063	Yes
210	4670	4670.0	0.0	0.0	The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification.	P Lauren	Acta Pathol Microbiol Scand	1965	14320675	Yes
211	9314	4657.0	237.33	118.7	Improved tools for biological sequence comparison.	W R Pearson, D J Lipman	Proc Natl Acad Sci U S A	1988	3162770	Yes
212	4653	4653.0	106.77	106.8	ras oncogenes in human cancer: a review.	J L Bos	Cancer Res	1989	2547513	No
213	4650	4650.0	158.63	158.6	The pathogenesis of atherosclerosis--an update.	R Ross	N Engl J Med	1986	3511384	No
214	4648	4648.0	118.49	118.5	Emotion circuits in the brain.	J E LeDoux	Annu Rev Neurosci	2000	10845062	No
215	4640	4640.0	133.8	133.8	A modified poisson regression approach to prospective studies with binary data.	Guangyong Zou	Am J Epidemiol	2004	15033648	Yes
216	27753	4625.5	3485.68	580.9	Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.	Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal	CA Cancer J Clin	2018	30207593	Yes
217	9242	4621.0	228.48	114.2	A genetic model for colorectal tumorigenesis.	E R Fearon, B Vogelstein	Cell	1990	2188735	No
218	13853	4617.7	487.27	162.4	Nitric oxide: physiology, pathophysiology, and pharmacology.	S Moncada, R M Palmer, E A Higgs	Pharmacol Rev	1991	1852778	No
219	9229	4614.5	225.11	112.6	Comparative protein modelling by satisfaction of spatial restraints.	A Sali, T L Blundell	J Mol Biol	1993	8254673	Yes
220	4608	4608.0	104.27	104.3	Cancer cell cycles.	C J Sherr	Science	1996	8939849	No
221	4585	4585.0	0.0	0.0	Aggregation of blood platelets by adenosine diphosphate and its reversal.	G V Born	Nature	1962	13871375	Yes
222	4579	4579.0	0.0	0.0	A rapid banding technique for human chromosomes.	M Seabright	Lancet	1971	4107917	Yes
223	18276	4569.0	573.24	143.3	MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0.	Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir Kumar	Mol Biol Evol	2007	17488738	Yes
224	9112	4556.0	0.0	0.0	A new depression scale designed to be sensitive to change.	S A Montgomery, M Asberg	Br J Psychiatry	1979	444788	Yes
225	9037	4518.5	203.47	101.7	Inflammation and cancer.	Lisa M Coussens, Zena Werb	Nature	2002	12490959	No
226	9030	4515.0	0.0	0.0	Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).	J M McCord, I Fridovich	J Biol Chem	1969	5389100	Yes
227	9023	4511.5	207.71	103.9	The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.	John Hardy, Dennis J Selkoe	Science	2002	12130773	No
228	4509	4509.0	307.34	307.3	SHELXT - integrated space-group and crystal-structure determination.	George M Sheldrick	Acta Crystallogr A Found Adv	2015	25537383	Yes
229	8991	4495.5	263.83	131.9	EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis.	Arnaud Delorme, Scott Makeig	J Neurosci Methods	2004	15102499	Yes
230	4494	4494.0	0.0	0.0	The clonal evolution of tumor cell populations.	P C Nowell	Science	1976	959840	Yes
231	13481	4493.7	521.65	173.9	The positive and negative syndrome scale (PANSS) for schizophrenia.	S R Kay, A Fiszbein, L A Opler	Schizophr Bull	1987	3616518	Yes
232	4452	4452.0	97.75	97.8	ras genes.	M Barbacid	Annu Rev Biochem	1987	3304147	No
233	13356	4452.0	302.64	100.9	Refinement of macromolecular structures by the maximum-likelihood method.	G N Murshudov, A A Vagin, E J Dodson	Acta Crystallogr D Biol Crystallogr	1997	15299926	Yes
234	4446	4446.0	109.09	109.1	A new method for predicting signal sequence cleavage sites.	G von Heijne	Nucleic Acids Res	1986	3714490	Yes
235	8889	4444.5	0.0	0.0	A simplified method of evaluating dose-effect experiments.	J T Litchfield, F Wilcoxon	J Pharmacol Exp Ther	1949	18152921	Yes
236	4429	4429.0	95.81	95.8	Targeting HIF-1 for cancer therapy.	Gregg L Semenza	Nat Rev Cancer	2003	13130303	No
237	4414	4414.0	135.0	135.0	A fast diffeomorphic image registration algorithm.	John Ashburner	Neuroimage	2007	17761438	Yes
238	8816	4408.0	311.28	155.6	AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading.	Oleg Trott, Arthur J Olson	J Comput Chem	2010	19499576	Yes
239	4405	4405.0	0.0	0.0	The McGill Pain Questionnaire: major properties and scoring methods.	Ronald Melzack	Pain	1975	1235985	Yes
240	8807	4403.5	236.54	118.3	BEDTools: a flexible suite of utilities for comparing genomic features.	Aaron R Quinlan, Ira M Hall	Bioinformatics	2010	20110278	Yes
241	8787	4393.5	0.0	0.0	A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.	W M Bonner, R A Laskey	Eur J Biochem	1974	4850204	Yes
242	21915	4383.0	0.0	0.0	An inventory for measuring depression.	A T Beck, C H Ward, M Mendelson, J Mock, J Erbaugh	Arch Gen Psychiatry	1961	13688369	Yes
243	4360	4360.0	101.02	101.0	Alzheimer's disease: genes, proteins, and therapy.	D J Selkoe	Physiol Rev	2001	11274343	No
244	21784	4356.8	1162.3	232.5	MEGA6: Molecular Evolutionary Genetics Analysis version 6.0.	Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir Kumar	Mol Biol Evol	2013	24132122	Yes
245	4352	4352.0	89.59	89.6	Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.	M Kozak	Cell	1986	3943125	Yes
246	4348	4348.0	0.0	0.0	Index for rating diagnostic tests.	W J Youden	Cancer	1950	15405679	Yes
247	4344	4344.0	0.0	0.0	Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents.	M M Mesulam	J Histochem Cytochem	1978	24068	Yes
248	8680	4340.0	200.14	100.1	Primer3 on the WWW for general users and for biologist programmers.	S Rozen, H Skaletsky	Methods Mol Biol	2000	10547847	Yes
249	13011	4337.0	332.67	110.9	Inference of population structure using multilocus genotype data.	J K Pritchard, M Stephens, P Donnelly	Genetics	2000	10835412	Yes
250	4336	4336.0	85.67	85.7	DNA methylation patterns and epigenetic memory.	Adrian Bird	Genes Dev	2002	11782440	No
251	4330	4330.0	102.25	102.2	MUSCLE: a multiple sequence alignment method with reduced time and space complexity.	Robert C Edgar	BMC Bioinformatics	2004	15318951	Yes
252	17306	4326.5	615.59	153.9	G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences.	Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner	Behav Res Methods	2007	17695343	Yes
253	4310	4310.0	0.0	0.0	Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation.	W H Harris	J Bone Joint Surg Am	1969	5783851	Yes
254	4302	4302.0	99.99	100.0	Prions.	S B Prusiner	Proc Natl Acad Sci U S A	1998	9811807	No
255	4297	4297.0	112.7	112.7	Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C.	Y Nishizuka	Science	1992	1411571	No
256	8593	4296.5	0.0	0.0	Preparation of iodine-131 labelled human growth hormone of high specific activity.	W M Hunter, F C Greenwood	Nature	1962	14450081	Yes
257	4279	4279.0	0.0	0.0	The Limited In Vitro Lifetime Of Human Diploid Cell Strains.	L Hayflick	Exp Cell Res	1965	14315085	Yes
258	8550	4275.0	290.74	145.4	Operating characteristics of a rank correlation test for publication bias.	C B Begg, M Mazumdar	Biometrics	1994	7786990	Yes
259	4253	4253.0	113.48	113.5	The molecular heterogeneity of protein kinase C and its implications for cellular regulation.	Y Nishizuka	Nature	1988	3045562	No
260	8465	4232.5	0.0	0.0	Parkinsonism: onset, progression and mortality.	M M Hoehn, M D Yahr	Neurology	1967	6067254	Yes
261	4232	4232.0	120.38	120.4	Mild cognitive impairment as a diagnostic entity.	R C Petersen	J Intern Med	2004	15324362	No
262	4216	4216.0	112.75	112.8	Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation.	A H Wyllie	Nature	1980	6245367	Yes
263	4214	4214.0	168.79	168.8	Revisiting the behavioral model and access to medical care: does it matter?	R M Andersen	J Health Soc Behav	1995	7738325	Yes
264	4213	4213.0	94.52	94.5	Apoptosis by death factor.	S Nagata	Cell	1997	9039262	No
265	4212	4212.0	100.42	100.4	Cancer. p53, guardian of the genome.	D P Lane	Nature	1992	1614522	No
266	4208	4208.0	94.45	94.5	Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing.	S Henikoff	Gene	1984	6235151	Yes
267	25247	4207.8	1023.78	170.6	Global cancer statistics.	Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David Forman	CA Cancer J Clin	2011	21296855	Yes
268	4201	4201.0	0.0	0.0	Amino acid metabolism in mammalian cell cultures.	H Eagle	Science	1959	13675766	Yes
269	8387	4193.5	229.59	114.8	A synaptic model of memory: long-term potentiation in the hippocampus.	T V Bliss, G L Collingridge	Nature	1993	8421494	No
270	4191	4191.0	0.0	0.0	A relation between non-esterified fatty acids in plasma and the metabolism of glucose.	V P Dole	J Clin Invest	1956	13286333	Yes
271	4179	4179.0	0.0	0.0	The colorimetric estimation of formaldehyde by means of the Hantzsch reaction.	T Nash	Biochem J	1953	13105648	Yes
272	4173	4173.0	0.0	0.0	Estimation of nuclear population from microtome sections.	M Abercrombie	Anat Rec	1946	21015608	Yes
273	8317	4158.5	241.14	120.6	Differential expression analysis for sequence count data.	Simon Anders, Wolfgang Huber	Genome Biol	2010	20979621	Yes
274	8272	4136.0	247.71	123.9	The rise of graphene.	A K Geim, K S Novoselov	Nat Mater	2007	17330084	Yes
275	4132	4132.0	0.0	0.0	The genetical evolution of social behaviour. I.	W D Hamilton	J Theor Biol	1964	5875341	Yes
276	4124	4124.0	0.0	0.0	The need for a new medical model: a challenge for biomedicine.	G L Engel	Science	1977	847460	Yes
277	8239	4119.5	178.72	89.4	Genomic sequencing.	G M Church, W Gilbert	Proc Natl Acad Sci U S A	1984	6326095	Yes
278	8237	4118.5	0.0	0.0	Assessment of coma and impaired consciousness. A practical scale.	G Teasdale, B Jennett	Lancet	1974	4136544	Yes
279	8221	4110.5	195.76	97.9	SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling.	N Guex, M C Peitsch	Electrophoresis	1997	9504803	Yes
280	16405	4101.2	0.0	0.0	A new and rapid colorimetric determination of acetylcholinesterase activity.	G L Ellman, K D Courtney, V Andres, R M Feather-Stone	Biochem Pharmacol	1961	13726518	Yes
281	4096	4096.0	99.19	99.2	Mechanisms of angiogenesis.	W Risau	Nature	1997	9109485	No
282	4094	4094.0	87.3	87.3	The retinoblastoma protein and cell cycle control.	R A Weinberg	Cell	1995	7736585	No
283	24544	4090.7	1048.95	174.8	MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods.	Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir Kumar	Mol Biol Evol	2011	21546353	Yes
284	4090	4090.0	125.23	125.2	Glutamate neurotoxicity and diseases of the nervous system.	D W Choi	Neuron	1988	2908446	No
285	4073	4073.0	0.0	0.0	The determination of enzyme inhibitor constants.	M Dixon	Biochem J	1953	13093635	Yes
286	4071	4071.0	86.95	87.0	Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.	C J Marshall	Cell	1995	7834738	No
287	4056	4056.0	0.0	0.0	Determination of protein: a modification of the Lowry method that gives a linear photometric response.	E F Hartree	Anal Biochem	1972	4115981	Yes
288	4049	4049.0	88.78	88.8	Alternative activation of macrophages.	Siamon Gordon	Nat Rev Immunol	2003	12511873	No
289	4017	4017.0	75.61	75.6	Generalized lacZ expression with the ROSA26 Cre reporter strain.	P Soriano	Nat Genet	1999	9916792	Yes
290	4002	4002.0	80.17	80.2	The phosphoinositide 3-kinase pathway.	Lewis C Cantley	Science	2002	12040186	No
291	3985	3985.0	0.0	0.0	Staining of tissue sections for electron microscopy with heavy metals.	M L Watson	J Biophys Biochem Cytol	1958	13563554	Yes
292	3969	3969.0	0.0	0.0	Bone: formation by autoinduction.	M R Urist	Science	1965	5319761	Yes
293	3958	3958.0	126.53	126.5	Bacterial evolution.	C R Woese	Microbiol Rev	1987	2439888	No
294	3948	3948.0	103.47	103.5	Integrins: a family of cell surface receptors.	R O Hynes	Cell	1987	3028640	No
295	3948	3948.0	0.0	0.0	Disc Electrophoresis. I. Background And Theory.	L Ornstein	Ann N Y Acad Sci	1964	14240533	Yes
296	3938	3938.0	121.63	121.6	How mitochondria produce reactive oxygen species.	Michael P Murphy	Biochem J	2009	19061483	No
297	3924	3924.0	86.92	86.9	Wnt/beta-catenin signaling in development and disease.	Hans Clevers	Cell	2006	17081971	No
298	7844	3922.0	0.0	0.0	Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.	H Aviv, P Leder	Proc Natl Acad Sci U S A	1972	4504350	Yes
299	3908	3908.0	0.0	0.0	The detection of disease clustering and a generalized regression approach.	N Mantel	Cancer Res	1967	6018555	Yes
300	3906	3906.0	129.6	129.6	Tissue destruction by neutrophils.	S J Weiss	N Engl J Med	1989	2536474	No
301	3879	3879.0	0.0	0.0	Pharmacological implications of microsomal enzyme induction.	A H Conney	Pharmacol Rev	1967	4383307	Yes
302	3873	3873.0	160.84	160.8	An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies.	Peter C Austin	Multivariate Behav Res	2011	21818162	Yes
303	3872	3872.0	120.74	120.7	Nitric oxide as a secretory product of mammalian cells.	C Nathan	FASEB J	1992	1381691	No
304	3863	3863.0	107.48	107.5	What is the evidence that tumors are angiogenesis dependent?	J Folkman	J Natl Cancer Inst	1990	1688381	No
305	7709	3854.5	0.0	0.0	Functional Evaluation: The Barthel Index.	F I Mahoney, D W Barthel	Md State Med J	1965	14258950	Yes
306	11518	3839.3	828.25	276.1	Cancer statistics, 2016.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2016	26742998	Yes
307	7649	3824.5	0.0	0.0	Assessment of older people: self-maintaining and instrumental activities of daily living.	M P Lawton, E M Brody	Gerontologist	1969	5349366	Yes
308	3822	3822.0	87.53	87.5	PAML: a program package for phylogenetic analysis by maximum likelihood.	Z Yang	Comput Appl Biosci	1997	9367129	Yes
309	11397	3799.0	0.0	0.0	Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.	W H Habig, M J Pabst, W B Jakoby	J Biol Chem	1974	4436300	Yes
310	7596	3798.0	0.0	0.0	Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.	D E Paglia, W N Valentine	J Lab Clin Med	1967	6066618	Yes
311	3774	3774.0	80.53	80.5	A catalogue of splice junction sequences.	S M Mount	Nucleic Acids Res	1982	7063411	Yes
312	3761	3761.0	0.0	0.0	New methods for calculating metabolic rate with special reference to protein metabolism.	J B De B Weir	J Physiol	1949	15394301	Yes
313	3759	3759.0	85.11	85.1	Atherosclerosis.	A J Lusis	Nature	2000	11001066	No
314	3758	3758.0	104.76	104.8	Revisions in the International System for Staging Lung Cancer.	C F Mountain	Chest	1997	9187198	Yes
315	3757	3757.0	0.0	0.0	Estimation of the molecular weights of proteins by Sephadex gel-filtration.	P Andrews	Biochem J	1964	4158310	Yes
316	7492	3746.0	185.62	92.8	Collective dynamics of 'small-world' networks.	D J Watts, S H Strogatz	Nature	1998	9623998	Yes
317	3741	3741.0	0.0	0.0	Preparation of isolated rat liver cells.	P O Seglen	Methods Cell Biol	1976	177845	No
318	3732	3732.0	140.31	140.3	EuroQol: the current state of play.	R Brooks	Health Policy	1996	10158943	No
319	3730	3730.0	107.98	108.0	Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity.	J H Morrissey	Anal Biochem	1981	6172996	Yes
320	7444	3722.0	220.66	110.3	Estimating F-Statistics For The Analysis Of Population Structure.	B S Weir, C Clark Cockerham	Evolution	1984	28563791	Yes
321	3719	3719.0	80.91	80.9	The green fluorescent protein.	R Y Tsien	Annu Rev Biochem	1998	9759496	No
322	7429	3714.5	141.34	70.7	A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.	R S Sikorski, P Hieter	Genetics	1989	2659436	Yes
323	11126	3708.7	215.24	71.7	Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.	J D Dignam, R M Lebovitz, R G Roeder	Nucleic Acids Res	1983	6828386	Yes
324	3703	3703.0	0.0	0.0	A membrane-filter technique for the detection of complementary DNA.	D T Denhardt	Biochem Biophys Res Commun	1966	5963888	Yes
325	7394	3697.0	179.49	89.7	MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification.	Jürgen Cox, Matthias Mann	Nat Biotechnol	2008	19029910	Yes
326	3696	3696.0	131.17	131.2	Whatever happened to qualitative description?	M Sandelowski	Res Nurs Health	2000	10940958	No
327	22143	3690.5	745.44	124.2	Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.	D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C Turner	Diabetologia	1985	3899825	Yes
328	3683	3683.0	124.89	124.9	Updating P300: an integrative theory of P3a and P3b.	John Polich	Clin Neurophysiol	2007	17573239	No
329	11040	3680.0	0.0	0.0	Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.	J F Kerr, A H Wyllie, A R Currie	Br J Cancer	1972	4561027	No
330	7321	3660.5	211.66	105.8	Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy.	Florian Weigend, Reinhart Ahlrichs	Phys Chem Chem Phys	2005	16240044	Yes
331	3659	3659.0	0.0	0.0	A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients.	E Pfeiffer	J Am Geriatr Soc	1975	1159263	Yes
332	10976	3658.7	495.25	165.1	Development and validation of brief measures of positive and negative affect: the PANAS scales.	D Watson, L A Clark, A Tellegen	J Pers Soc Psychol	1988	3397865	Yes
333	3653	3653.0	91.0	91.0	Multiple sequence alignment with hierarchical clustering.	F Corpet	Nucleic Acids Res	1988	2849754	Yes
334	3644	3644.0	99.11	99.1	Staphylococcus aureus infections.	F D Lowy	N Engl J Med	1998	9709046	No
335	3643	3643.0	89.54	89.5	Caspases: the executioners of apoptosis.	G M Cohen	Biochem J	1997	9337844	No
336	3642	3642.0	88.36	88.4	Free R value: a novel statistical quantity for assessing the accuracy of crystal structures.	A T Brünger	Nature	1992	18481394	Yes
337	7276	3638.0	182.65	91.3	Mitochondria and apoptosis.	D R Green, J C Reed	Science	1998	9721092	No
338	3631	3631.0	84.57	84.6	Tandem repeats finder: a program to analyze DNA sequences.	G Benson	Nucleic Acids Res	1999	9862982	Yes
339	3626	3626.0	77.62	77.6	TGF-beta signal transduction.	J Massagué	Annu Rev Biochem	1998	9759503	No
340	7233	3616.5	0.0	0.0	The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.	R C Graham, M J Karnovsky	J Histochem Cytochem	1966	5962951	Yes
341	14456	3614.0	400.79	100.2	Global cancer statistics, 2002.	D Max Parkin, Freddie Bray, J Ferlay, Paola Pisani	CA Cancer J Clin	2005	15761078	Yes
342	3607	3607.0	0.0	0.0	Evolution in Mendelian Populations.	S Wright	Genetics	1931	17246615	Yes
343	3597	3597.0	91.71	91.7	Why most published research findings are false.	John P A Ioannidis	PLoS Med	2005	16060722	Yes
344	3594	3594.0	109.77	109.8	Inositol trisphosphate and diacylglycerol as second messengers.	M J Berridge	Biochem J	1984	6146314	No
345	3587	3587.0	0.0	0.0	Principles that govern the folding of protein chains.	C B Anfinsen	Science	1973	4124164	Yes
346	7147	3573.5	288.65	144.3	Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models.	Kristopher J Preacher, Andrew F Hayes	Behav Res Methods	2008	18697684	Yes
347	7126	3563.0	229.85	114.9	RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome.	Bo Li, Colin N Dewey	BMC Bioinformatics	2011	21816040	Yes
348	3552	3552.0	65.86	65.9	Somatic generation of antibody diversity.	S Tonegawa	Nature	1983	6300689	No
349	14196	3549.0	420.62	105.2	Features and development of Coot.	P Emsley, B Lohkamp, W G Scott, K Cowtan	Acta Crystallogr D Biol Crystallogr	2010	20383002	Yes
350	3534	3534.0	74.02	74.0	Hypoxia--a key regulatory factor in tumour growth.	Adrian L Harris	Nat Rev Cancer	2002	11902584	No
351	7066	3533.0	251.57	125.8	DnaSP v5: a software for comprehensive analysis of DNA polymorphism data.	P Librado, J Rozas	Bioinformatics	2009	19346325	Yes
352	3525	3525.0	75.99	76.0	Protein secondary structure prediction based on position-specific scoring matrices.	D T Jones	J Mol Biol	1999	10493868	Yes
353	10568	3522.7	889.63	296.5	Cancer Statistics, 2017.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2017	28055103	Yes
354	3509	3509.0	70.82	70.8	Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.	G R Martin	Proc Natl Acad Sci U S A	1981	6950406	Yes
355	3506	3506.0	82.58	82.6	Novel proteinaceous infectious particles cause scrapie.	S B Prusiner	Science	1982	6801762	Yes
356	3502	3502.0	98.71	98.7	Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group.	R B D'Agostino	Stat Med	1998	9802183	Yes
357	3502	3502.0	0.0	0.0	Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit.	J Cohen	Psychol Bull	1968	19673146	Yes
358	6995	3497.5	132.65	66.3	Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.	A H Brand, N Perrimon	Development	1993	8223268	Yes
359	3496	3496.0	98.67	98.7	Biological roles of oligosaccharides: all of the theories are correct.	A Varki	Glycobiology	1993	8490246	No
360	3492	3492.0	101.99	102.0	Sequencing technologies - the next generation.	Michael L Metzker	Nat Rev Genet	2010	19997069	No
361	3482	3482.0	0.0	0.0	Statistical estimations in enzyme kinetics.	G N Wilkinson	Biochem J	1961	13785321	Yes
362	3479	3479.0	134.17	134.2	Measuring the accuracy of diagnostic systems.	J A Swets	Science	1988	3287615	No
363	3479	3479.0	84.68	84.7	Marrow stromal cells as stem cells for nonhematopoietic tissues.	D J Prockop	Science	1997	9082988	No
364	3474	3474.0	118.7	118.7	Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD.	Russell A Barkley	Psychol Bull	1997	9000892	No
365	3472	3472.0	80.54	80.5	Protein production by auto-induction in high density shaking cultures.	F William Studier	Protein Expr Purif	2005	15915565	Yes
366	6940	3470.0	0.0	0.0	A new method for sequencing DNA.	A M Maxam, W Gilbert	Proc Natl Acad Sci U S A	1977	265521	Yes
367	3463	3463.0	0.0	0.0	Spectroscopic determination of tryptophan and tyrosine in proteins.	H Edelhoch	Biochemistry	1967	6049437	Yes
368	17310	3462.0	504.61	100.9	Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.	O P Hamill, A Marty, E Neher, B Sakmann, F J Sigworth	Pflugers Arch	1981	6270629	Yes
369	6905	3452.5	0.0	0.0	Radiological assessment of osteo-arthrosis.	J H Kellgren, J S Lawrence	Ann Rheum Dis	1957	13498604	Yes
370	6890	3445.0	156.93	78.5	Functional rafts in cell membranes.	K Simons, E Ikonen	Nature	1997	9177342	No
371	6888	3444.0	255.9	128.0	Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness.	U H Graneheim, B Lundman	Nurse Educ Today	2004	14769454	No
372	6884	3442.0	164.15	82.1	"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.	A P Feinberg, B Vogelstein	Anal Biochem	1984	6329026	Yes
373	10319	3439.7	398.54	132.8	A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity.	J Ware, M Kosinski, S D Keller	Med Care	1996	8628042	Yes
374	3432	3432.0	78.61	78.6	Instability and decay of the primary structure of DNA.	T Lindahl	Nature	1993	8469282	No
375	3432	3432.0	0.0	0.0	The Scree Test For The Number Of Factors.	R B Cattell	Multivariate Behav Res	1966	26828106	Yes
376	3430	3430.0	81.65	81.7	Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.	Rakesh K Jain	Science	2005	15637262	No
377	6852	3426.0	177.92	89.0	tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence.	T M Lowe, S R Eddy	Nucleic Acids Res	1997	9023104	Yes
378	3416	3416.0	0.0	0.0	Generalized expectancies for internal versus external control of reinforcement.	J B Rotter	Psychol Monogr	1966	5340840	No
379	3392	3392.0	0.0	0.0	Basic principles of ROC analysis.	C E Metz	Semin Nucl Med	1978	112681	Yes
380	3392	3392.0	70.98	71.0	Mammalian neural stem cells.	F H Gage	Science	2000	10688783	No
381	10130	3376.7	0.0	0.0	The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity.	F C Greenwood, W M Hunter, J S Glover	Biochem J	1963	14097352	Yes
382	3375	3375.0	0.0	0.0	The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid.	J F Woessner	Arch Biochem Biophys	1961	13786180	Yes
383	6740	3370.0	207.19	103.6	BEAST: Bayesian evolutionary analysis by sampling trees.	Alexei J Drummond, Andrew Rambaut	BMC Evol Biol	2007	17996036	Yes
384	6726	3363.0	289.62	144.8	The timed "Up & Go": a test of basic functional mobility for frail elderly persons.	D Podsiadlo, S Richardson	J Am Geriatr Soc	1991	1991946	Yes
385	3344	3344.0	103.07	103.1	Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans.	L R Squire	Psychol Rev	1992	1594723	No
386	3341	3341.0	83.67	83.7	The heat-shock response.	S Lindquist	Annu Rev Biochem	1986	2427013	No
387	10023	3341.0	1132.26	377.4	Cancer statistics, 2018.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2018	29313949	Yes
388	6672	3336.0	173.52	86.8	TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.	T R Mosmann, R L Coffman	Annu Rev Immunol	1989	2523712	No
389	3328	3328.0	77.39	77.4	Scaling and assessment of data quality.	Philip Evans	Acta Crystallogr D Biol Crystallogr	2006	16369096	No
390	3327	3327.0	68.89	68.9	Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.	M Kozak	Nucleic Acids Res	1984	6694911	Yes
391	9961	3320.3	465.85	155.3	Cancer statistics, 2013.	Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal	CA Cancer J Clin	2013	23335087	Yes
392	3320	3320.0	78.85	78.8	The dendritic cell system and its role in immunogenicity.	R M Steinman	Annu Rev Immunol	1991	1910679	No
393	6636	3318.0	177.74	88.9	Control of goal-directed and stimulus-driven attention in the brain.	Maurizio Corbetta, Gordon L Shulman	Nat Rev Neurosci	2002	11994752	No
394	3317	3317.0	88.57	88.6	Microglia: a sensor for pathological events in the CNS.	G W Kreutzberg	Trends Neurosci	1996	8843599	No
395	3315	3315.0	100.26	100.3	What's wrong with Bonferroni adjustments.	T V Perneger	BMJ	1998	9553006	No
396	6627	3313.5	193.08	96.5	Ab initio molecular dynamics for liquid metals.	Kresse, Hafner	Phys Rev B Condens Matter	1993	10004490	Yes
397	3312	3312.0	68.96	69.0	The scanning model for translation: an update.	M Kozak	J Cell Biol	1989	2645293	No
398	3312	3312.0	0.0	0.0	Equilibrium Ultracentrifugation Of Dilute Solutions.	D A Yphantis	Biochemistry	1964	14155091	Yes
399	3304	3304.0	0.0	0.0	Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.	J D Rowley	Nature	1973	4126434	Yes
400	3303	3303.0	111.14	111.1	Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence.	Ilan H Meyer	Psychol Bull	2003	12956539	No
401	3299	3299.0	84.72	84.7	Gene regulation by steroid hormones.	M Beato	Cell	1989	2644044	No
402	3298	3298.0	65.3	65.3	Signal transduction by the JNK group of MAP kinases.	R J Davis	Cell	2000	11057897	No
403	3292	3292.0	100.24	100.2	Protective and damaging effects of stress mediators.	B S McEwen	N Engl J Med	1998	9428819	No
404	3289	3289.0	92.3	92.3	Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.	R W Mahley	Science	1988	3283935	No
405	3280	3280.0	0.0	0.0	Some factors in the interpretation of protein denaturation.	W Kauzmann	Adv Protein Chem	1959	14404936	Yes
406	3276	3276.0	113.96	114.0	genepop'007: a complete re-implementation of the genepop software for Windows and Linux.	François Rousset	Mol Ecol Resour	2008	21585727	Yes
407	9814	3271.3	420.49	140.2	Cancer statistics, 2012.	Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal	CA Cancer J Clin	2012	22237781	Yes
408	3267	3267.0	116.34	116.3	How do you feel--now? The anterior insula and human awareness.	A D Bud Craig	Nat Rev Neurosci	2009	19096369	No
409	3264	3264.0	129.59	129.6	A concordance correlation coefficient to evaluate reproducibility.	L I Lin	Biometrics	1989	2720055	Yes
410	13042	3260.5	305.54	76.4	Improved methods for building protein models in electron density maps and the location of errors in these models.	T A Jones, J Y Zou, S W Cowan, M Kjeldgaard	Acta Crystallogr A	1991	2025413	Yes
411	6511	3255.5	124.26	62.1	Translating the histone code.	T Jenuwein, C D Allis	Science	2001	11498575	No
412	3254	3254.0	84.68	84.7	Biologic basis for interleukin-1 in disease.	C A Dinarello	Blood	1996	8630372	No
413	3251	3251.0	0.0	0.0	Observational study of behavior: sampling methods.	J Altmann	Behaviour	1974	4597405	No
414	6496	3248.0	249.01	124.5	The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay.	I F Benzie, J J Strain	Anal Biochem	1996	8660627	Yes
415	6456	3228.0	0.0	0.0	Receptive fields, binocular interaction and functional architecture in the cat's visual cortex.	D H Hubel, T N Wiesel	J Physiol	1962	14449617	Yes
416	3226	3226.0	88.23	88.2	The adolescent brain and age-related behavioral manifestations.	L P Spear	Neurosci Biobehav Rev	2000	10817843	No
417	3225	3225.0	0.0	0.0	Estimation of average heterozygosity and genetic distance from a small number of individuals.	M Nei	Genetics	1978	17248844	Yes
418	3224	3224.0	128.89	128.9	Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine.	O W Griffith	Anal Biochem	1980	7416462	Yes
419	6432	3216.0	2067.08	1033.5	Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention.	Zunyou Wu, Jennifer M McGoogan	JAMA	2020	32091533	Yes
420	3210	3210.0	93.11	93.1	Inositol trisphosphate and diacylglycerol: two interacting second messengers.	M J Berridge	Annu Rev Biochem	1987	3304132	No
421	3200	3200.0	97.41	97.4	Soft self-consistent pseudopotentials in a generalized eigenvalue formalism.	Vanderbilt	Phys Rev B Condens Matter	1990	9993096	Yes
422	3200	3200.0	88.46	88.5	Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?	Kim A Brogden	Nat Rev Microbiol	2005	15703760	No
423	3194	3194.0	77.18	77.2	Glutamate uptake.	N C Danbolt	Prog Neurobiol	2001	11369436	No
424	3193	3193.0	77.22	77.2	Nonalcoholic fatty liver disease.	Paul Angulo	N Engl J Med	2002	11961152	No
425	12769	3192.2	544.85	136.2	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	Ann Intern Med	2009	19622511	No
426	9559	3186.3	575.58	191.9	Cancer statistics, 2015.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2015	25559415	Yes
427	3182	3182.0	84.55	84.5	Oxidative stress, antioxidants and stress tolerance.	Ron Mittler	Trends Plant Sci	2002	12234732	No
428	3178	3178.0	0.0	0.0	Diffusion-in-gel methods for immunological analysis.	O Ouchterlony	Prog Allergy	1958	13578996	Yes
429	6342	3171.0	166.58	83.3	An integrative theory of prefrontal cortex function.	E K Miller, J D Cohen	Annu Rev Neurosci	2001	11283309	No
430	3162	3162.0	79.49	79.5	The transforming growth factor-beta family.	J Massagué	Annu Rev Cell Biol	1990	2177343	No
431	3157	3157.0	68.39	68.4	Profile hidden Markov models.	S R Eddy	Bioinformatics	1998	9918945	No
432	9461	3153.7	315.63	105.2	Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.	E R DeLong, D M DeLong, D L Clarke-Pearson	Biometrics	1988	3203132	Yes
433	3151	3151.0	0.0	0.0	Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.	S W Kessler	J Immunol	1975	1102604	Yes
434	3141	3141.0	85.41	85.4	ABC transporters: from microorganisms to man.	C F Higgins	Annu Rev Cell Biol	1992	1282354	No
435	3137	3137.0	73.78	73.8	Tolerance, danger, and the extended family.	P Matzinger	Annu Rev Immunol	1994	8011301	No
436	3137	3137.0	0.0	0.0	The magical number seven plus or minus two: some limits on our capacity for processing information.	G A Miller	Psychol Rev	1956	13310704	Yes
437	3133	3133.0	84.55	84.5	I-TASSER server for protein 3D structure prediction.	Yang Zhang	BMC Bioinformatics	2008	18215316	Yes
438	3121	3121.0	0.0	0.0	Notes on sugar determination.	M Smogyi	J Biol Chem	1952	14938350	Yes
439	18720	3120.0	1164.76	194.1	Global cancer statistics, 2012.	Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin Jemal	CA Cancer J Clin	2015	25651787	Yes
440	9359	3119.7	390.62	130.2	A global measure of perceived stress.	S Cohen, T Kamarck, R Mermelstein	J Health Soc Behav	1983	6668417	Yes
441	3119	3119.0	100.92	100.9	Graphene: status and prospects.	A K Geim	Science	2009	19541989	Yes
442	12475	3118.8	327.4	81.8	Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.	Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg	Genome Biol	2009	19261174	Yes
443	3112	3112.0	104.55	104.5	Modeling valuations for EuroQol health states.	P Dolan	Med Care	1997	9366889	Yes
444	9332	3110.7	1600.99	533.7	Cancer statistics, 2019.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2019	30620402	Yes
445	6212	3106.0	0.0	0.0	Microsomal lipid peroxidation.	J A Buege, S D Aust	Methods Enzymol	1978	672633	Yes
446	3100	3100.0	85.7	85.7	The origins and the future of microfluidics.	George M Whitesides	Nature	2006	16871203	No
447	3079	3079.0	64.11	64.1	CpG-rich islands and the function of DNA methylation.	A P Bird	Nature	1986	2423876	No
448	6138	3069.0	186.73	93.4	Velvet: algorithms for de novo short read assembly using de Bruijn graphs.	Daniel R Zerbino, Ewan Birney	Genome Res	2008	18349386	Yes
449	3065	3065.0	62.51	62.5	STATs and gene regulation.	J E Darnell	Science	1997	9287210	No
450	3063	3063.0	69.08	69.1	Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.	H F Dvorak	N Engl J Med	1986	3537791	No
451	3063	3063.0	58.79	58.8	Cell signaling by receptor tyrosine kinases.	J Schlessinger	Cell	2000	11057895	No
452	6121	3060.5	0.0	0.0	Human malaria parasites in continuous culture.	W Trager, J B Jensen	Science	1976	781840	Yes
453	3051	3051.0	72.87	72.9	WHAT IF: a molecular modeling and drug design program.	G Vriend	J Mol Graph	1990	2268628	Yes
454	3049	3049.0	73.41	73.4	Folding DNA to create nanoscale shapes and patterns.	Paul W K Rothemund	Nature	2006	16541064	Yes
455	6096	3048.0	121.27	60.6	The ubiquitin system.	A Hershko, A Ciechanover	Annu Rev Biochem	1998	9759494	No
456	6093	3046.5	155.85	77.9	WGCNA: an R package for weighted correlation network analysis.	Peter Langfelder, Steve Horvath	BMC Bioinformatics	2008	19114008	Yes
457	3041	3041.0	68.0	68.0	Activators and target genes of Rel/NF-kappaB transcription factors.	H L Pahl	Oncogene	1999	10602461	No
458	9090	3030.0	312.73	104.2	Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor.	R M Palmer, A G Ferrige, S Moncada	Nature	1987	3495737	Yes
459	6045	3022.5	128.0	64.0	Statistical significance for genomewide studies.	John D Storey, Robert Tibshirani	Proc Natl Acad Sci U S A	2003	12883005	Yes
460	6042	3021.0	136.15	68.1	Angiogenesis in cancer and other diseases.	P Carmeliet, R K Jain	Nature	2000	11001068	No
461	3019	3019.0	0.0	0.0	Towards a network theory of the immune system.	N K Jerne	Ann Immunol (Paris)	1974	4142565	No
462	6014	3007.0	170.73	85.4	The basics of epithelial-mesenchymal transition.	Raghu Kalluri, Robert A Weinberg	J Clin Invest	2009	19487818	No
463	2998	2998.0	0.0	0.0	A study of fixation for electron microscopy.	G E Palade	J Exp Med	1952	14927794	Yes
464	2993	2993.0	70.51	70.5	Cadherin cell adhesion receptors as a morphogenetic regulator.	M Takeichi	Science	1991	2006419	No
465	2993	2993.0	74.22	74.2	Neural networks and physical systems with emergent collective computational abilities.	J J Hopfield	Proc Natl Acad Sci U S A	1982	6953413	Yes
466	2990	2990.0	74.48	74.5	Wound healing--aiming for perfect skin regeneration.	P Martin	Science	1997	9082989	No
467	2986	2986.0	97.85	97.8	Emerging adulthood. A theory of development from the late teens through the twenties.	J J Arnett	Am Psychol	2000	10842426	Yes
468	2983	2983.0	74.65	74.7	Photoelectrochemical cells.	M Grätzel	Nature	2001	11713540	Yes
469	2974	2974.0	0.0	0.0	A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide.	S Hakomori	J Biochem	1964	14135466	Yes
470	5940	2970.0	232.57	116.3	Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows.	Laurent Excoffier, Heidi E L Lischer	Mol Ecol Resour	2010	21565059	Yes
471	2968	2968.0	0.0	0.0	The gel-filtration behaviour of proteins related to their molecular weights over a wide range.	P Andrews	Biochem J	1965	5862401	Yes
472	2961	2961.0	86.34	86.3	EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis.	W Klimesch	Brain Res Brain Res Rev	1999	10209231	No
473	2960	2960.0	82.97	83.0	Hay fever, hygiene, and household size.	D P Strachan	BMJ	1989	2513902	Yes
474	2954	2954.0	76.16	76.2	The basis of anisotropic water diffusion in the nervous system - a technical review.	Christian Beaulieu	NMR Biomed	2002	12489094	No
475	5898	2949.0	124.96	62.5	Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.	D B Smith, K S Johnson	Gene	1988	3047011	Yes
476	2945	2945.0	79.19	79.2	The pathobiology of diabetic complications: a unifying mechanism.	Michael Brownlee	Diabetes	2005	15919781	No
477	5876	2938.0	145.09	72.5	Inference of macromolecular assemblies from crystalline state.	Evgeny Krissinel, Kim Henrick	J Mol Biol	2007	17681537	Yes
478	2935	2935.0	72.82	72.8	Phase separation of integral membrane proteins in Triton X-114 solution.	C Bordier	J Biol Chem	1981	6257680	Yes
479	2934	2934.0	0.0	0.0	Gene action in the X-chromosome of the mouse (Mus musculus L.).	M F Lyon	Nature	1961	13764598	Yes
480	2933	2933.0	0.0	0.0	Transformed up-down methods in psychoacoustics.	H Levitt	J Acoust Soc Am	1971	5541744	Yes
481	20520	2931.4	483.19	69.0	UCSF Chimera--a visualization system for exploratory research and analysis.	Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin	J Comput Chem	2004	15264254	Yes
482	2917	2917.0	64.77	64.8	Mechanisms of angiogenesis and arteriogenesis.	P Carmeliet	Nat Med	2000	10742145	No
483	2910	2910.0	91.05	91.0	Matrix metalloproteinases and their inhibitors in connective tissue remodeling.	J F Woessner	FASEB J	1991	1850705	No
484	2905	2905.0	0.0	0.0	Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid.	W C Schneider	J Biol Chem	1945	21005736	Yes
485	2904	2904.0	98.08	98.1	Functions of DNA methylation: islands, start sites, gene bodies and beyond.	Peter A Jones	Nat Rev Genet	2012	22641018	No
486	2902	2902.0	0.0	0.0	Catheter replacement of the needle in percutaneous arteriography; a new technique.	S I Seldinger	Acta radiol	1953	13057644	Yes
487	8704	2901.3	243.42	81.1	Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.	Y Gavrieli, Y Sherman, S A Ben-Sasson	J Cell Biol	1992	1400587	Yes
488	8677	2892.3	180.51	60.2	Significance analysis of microarrays applied to the ionizing radiation response.	V G Tusher, R Tibshirani, G Chu	Proc Natl Acad Sci U S A	2001	11309499	Yes
489	2887	2887.0	69.82	69.8	Chemokines--chemotactic cytokines that mediate inflammation.	A D Luster	N Engl J Med	1998	9459648	No
490	2884	2884.0	64.98	65.0	Angiogenesis in health and disease.	Peter Carmeliet	Nat Med	2003	12778163	No
491	2883	2883.0	75.6	75.6	How do you feel? Interoception: the sense of the physiological condition of the body.	A D Craig	Nat Rev Neurosci	2002	12154366	No
492	2883	2883.0	60.93	60.9	The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited.	Isaiah J Fidler	Nat Rev Cancer	2003	12778135	No
493	2881	2881.0	165.66	165.7	Executive functions.	Adele Diamond	Annu Rev Psychol	2013	23020641	No
494	5755	2877.5	228.54	114.3	Management of hepatocellular carcinoma: an update.	Jordi Bruix, Morris Sherman	Hepatology	2011	21374666	No
495	2870	2870.0	51.34	51.3	One-step gene disruption in yeast.	R J Rothstein	Methods Enzymol	1983	6310324	Yes
496	8596	2865.3	0.0	0.0	The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum.	R J Havel, H A Eder, J H Bragdon	J Clin Invest	1955	13252080	Yes
497	5729	2864.5	163.06	81.5	Inositol trisphosphate, a novel second messenger in cellular signal transduction.	M J Berridge, R F Irvine	Nature	1984	6095092	No
498	2863	2863.0	79.42	79.4	Mesenchymal stem cells.	A I Caplan	J Orthop Res	1991	1870029	Yes
499	2859	2859.0	0.0	0.0	Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay.	B E Murphy	J Clin Endocrinol Metab	1967	4291524	Yes
500	2859	2859.0	118.04	118.0	Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy.	T E Moffitt	Psychol Rev	1993	8255953	No
501	2859	2859.0	90.18	90.2	Development of a classification system for periodontal diseases and conditions.	G C Armitage	Ann Periodontol	1999	10863370	No
502	2856	2856.0	0.0	0.0	Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method.	L Svennerholm	Biochim Biophys Acta	1957	13436486	Yes
503	5710	2855.0	138.1	69.0	Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase.	C Tuerk, L Gold	Science	1990	2200121	Yes
504	2855	2855.0	63.46	63.5	Protein folding and misfolding.	Christopher M Dobson	Nature	2003	14685248	No
505	5704	2852.0	129.17	64.6	Toll-like receptor signalling.	Shizuo Akira, Kiyoshi Takeda	Nat Rev Immunol	2004	15229469	No
506	2850	2850.0	72.85	72.8	Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies.	Ting-Chao Chou	Pharmacol Rev	2006	16968952	No
507	8543	2847.7	190.24	63.4	Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.	Benjamin P Lewis, Christopher B Burge, David P Bartel	Cell	2005	15652477	Yes
508	8541	2847.0	0.0	0.0	Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane.	G Fairbanks, T L Steck, D F Wallach	Biochemistry	1971	4326772	Yes
509	2847	2847.0	61.91	61.9	Alzheimer's disease is a synaptic failure.	Dennis J Selkoe	Science	2002	12399581	No
510	5681	2840.5	0.0	0.0	Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain.	J Glowinski, L L Iversen	J Neurochem	1966	5950056	Yes
511	5673	2836.5	146.86	73.4	The plant immune system.	Jonathan D G Jones, Jeffery L Dangl	Nature	2006	17108957	No
512	2835	2835.0	84.12	84.1	Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis.	Thomas Welton	Chem Rev	1999	11849019	Yes
513	5662	2831.0	0.0	0.0	Superoxide dismutase: improved assays and an assay applicable to acrylamide gels.	C Beauchamp, I Fridovich	Anal Biochem	1971	4943714	Yes
514	2830	2830.0	110.86	110.9	Half a century of research on the Stroop effect: an integrative review.	C M MacLeod	Psychol Bull	1991	2034749	No
515	2830	2830.0	92.96	93.0	An empirical correction for absorption anisotropy.	R H Blessing	Acta Crystallogr A	1995	7702794	Yes
516	5657	2828.5	135.59	67.8	MicroRNA signatures in human cancers.	George A Calin, Carlo M Croce	Nat Rev Cancer	2006	17060945	No
517	8456	2818.7	228.87	76.3	Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists.	Da Wei Huang, Brad T Sherman, Richard A Lempicki	Nucleic Acids Res	2009	19033363	Yes
518	2817	2817.0	0.0	0.0	A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples.	E A Gehan	Biometrika	1965	14341275	Yes
519	2816	2816.0	55.0	55.0	RNA interference.	Gregory J Hannon	Nature	2002	12110901	No
520	5626	2813.0	0.0	0.0	A method for determining the sedimentation behavior of enzymes: application to protein mixtures.	R G Martin, B N Ames	J Biol Chem	1961	13767412	Yes
521	2811	2811.0	0.0	0.0	A study of the adrenotropic receptors.	R P Ahlquist	Am J Physiol	1948	18882199	Yes
522	11240	2810.0	454.33	113.6	APACHE II: a severity of disease classification system.	W A Knaus, E A Draper, D P Wagner, J E Zimmerman	Crit Care Med	1985	3928249	Yes
523	5616	2808.0	164.55	82.3	Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis.	S Duval, R Tweedie	Biometrics	2000	10877304	Yes
524	5609	2804.5	103.56	51.8	The language of covalent histone modifications.	B D Strahl, C D Allis	Nature	2000	10638745	Yes
525	2801	2801.0	59.49	59.5	Principles of CDK regulation.	D O Morgan	Nature	1995	7877684	No
526	2790	2790.0	92.81	92.8	Health promotion by social cognitive means.	Albert Bandura	Health Educ Behav	2004	15090118	Yes
527	2789	2789.0	94.3	94.3	Role of oxidative stress in development of complications in diabetes.	J W Baynes	Diabetes	1991	2010041	No
528	5578	2789.0	153.2	76.6	The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers.	J Vieira, J Messing	Gene	1982	6295879	Yes
529	5575	2787.5	0.0	0.0	Pain mechanisms: a new theory.	R Melzack, P D Wall	Science	1965	5320816	No
530	11147	2786.8	0.0	0.0	Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.	P W Rigby, M Dieckmann, C Rhodes, P Berg	J Mol Biol	1977	881736	Yes
531	5569	2784.5	0.0	0.0	Assessment of outcome after severe brain damage.	B Jennett, M Bond	Lancet	1975	46957	Yes
532	11133	2783.2	281.81	70.5	Haploview: analysis and visualization of LD and haplotype maps.	J C Barrett, B Fry, J Maller, M J Daly	Bioinformatics	2005	15297300	Yes
533	5561	2780.5	110.82	55.4	High-efficiency transformation of mammalian cells by plasmid DNA.	C Chen, H Okayama	Mol Cell Biol	1987	3670292	Yes
534	5551	2775.5	0.0	0.0	A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.	S Reitman, S Frankel	Am J Clin Pathol	1957	13458125	Yes
535	2775	2775.0	68.77	68.8	Obesity as a medical problem.	P G Kopelman	Nature	2000	10766250	No
536	2771	2771.0	0.0	0.0	Efficient trace-labelling of proteins with iodine.	A S McFARLANE	Nature	1958	13566175	Yes
537	5531	2765.5	146.27	73.1	Voxel-based morphometry--the methods.	J Ashburner, K J Friston	Neuroimage	2000	10860804	No
538	8285	2761.7	179.63	59.9	Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.	C M Gorman, L F Moffat, B H Howard	Mol Cell Biol	1982	6960240	Yes
539	5521	2760.5	0.0	0.0	The fluid mosaic model of the structure of cell membranes.	S J Singer, G L Nicolson	Science	1972	4333397	Yes
540	2746	2746.0	0.0	0.0	Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads.	P Cuatrecasas	J Biol Chem	1970	5432796	Yes
541	5487	2743.5	162.31	81.2	Projections of global mortality and burden of disease from 2002 to 2030.	Colin D Mathers, Dejan Loncar	PLoS Med	2006	17132052	Yes
542	2739	2739.0	84.13	84.1	Implications of normal brain development for the pathogenesis of schizophrenia.	D R Weinberger	Arch Gen Psychiatry	1987	3606332	Yes
543	2735	2735.0	96.67	96.7	The processing-speed theory of adult age differences in cognition.	T A Salthouse	Psychol Rev	1996	8759042	No
544	2734	2734.0	83.36	83.4	Drug combination studies and their synergy quantification using the Chou-Talalay method.	Ting-Chao Chou	Cancer Res	2010	20068163	Yes
545	2733	2733.0	126.89	126.9	The quality of care. How can it be assessed?	A Donabedian	JAMA	1988	3045356	No
546	2731	2731.0	92.02	92.0	Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report.	Sarah E Barlow	Pediatrics	2007	18055651	Yes
547	5461	2730.5	243.85	121.9	Revised methods for the Salmonella mutagenicity test.	D M Maron, B N Ames	Mutat Res	1983	6341825	Yes
548	2730	2730.0	0.0	0.0	Measurement of pain.	E C Huskisson	Lancet	1974	4139420	Yes
549	8186	2728.7	394.05	131.3	HTSeq--a Python framework to work with high-throughput sequencing data.	Simon Anders, Paul Theodor Pyl, Wolfgang Huber	Bioinformatics	2015	25260700	Yes
550	2722	2722.0	92.63	92.6	Hepatocellular carcinoma.	Hashem B El-Serag	N Engl J Med	2011	21992124	No
551	2720	2720.0	60.77	60.8	Cardiac excitation-contraction coupling.	Donald M Bers	Nature	2002	11805843	No
552	5434	2717.0	127.92	64.0	Caspases: enemies within.	N A Thornberry, Y Lazebnik	Science	1998	9721091	No
553	5433	2716.5	0.0	0.0	The serial cultivation of human diploid cell strains.	L Hayflick, P S Moorhead	Exp Cell Res	1961	13905658	Yes
554	5428	2714.0	131.97	66.0	Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.	T C Chou, P Talalay	Adv Enzyme Regul	1984	6382953	Yes
555	2712	2712.0	66.42	66.4	Cell death during development of the nervous system.	R W Oppenheim	Annu Rev Neurosci	1991	2031577	No
556	2705	2705.0	72.89	72.9	Recent advances with liposomes as pharmaceutical carriers.	Vladimir P Torchilin	Nat Rev Drug Discov	2005	15688077	No
557	2701	2701.0	61.06	61.1	Inflammatory bowel disease.	Daniel K Podolsky	N Engl J Med	2002	12167685	No
558	2701	2701.0	84.48	84.5	Non-coding RNAs in human disease.	Manel Esteller	Nat Rev Genet	2011	22094949	No
559	2699	2699.0	56.64	56.6	Toll-like receptors and innate immunity.	R Medzhitov	Nat Rev Immunol	2001	11905821	No
560	2698	2698.0	71.62	71.6	Optimal two-stage designs for phase II clinical trials.	R Simon	Control Clin Trials	1989	2702835	Yes
561	8088	2696.0	213.49	71.2	MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment.	Sudhir Kumar, Koichiro Tamura, Masatoshi Nei	Brief Bioinform	2004	15260895	Yes
562	2693	2693.0	65.37	65.4	Mitochondrial formation of reactive oxygen species.	Julio F Turrens	J Physiol	2003	14561818	No
563	2693	2693.0	73.0	73.0	Origin and physiological roles of inflammation.	Ruslan Medzhitov	Nature	2008	18650913	No
564	10769	2692.2	376.39	94.1	Cancer statistics, 2010.	Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth Ward	CA Cancer J Clin	2010	20610543	Yes
565	2683	2683.0	64.39	64.4	Structure and function of telomeres.	E H Blackburn	Nature	1991	1708110	No
566	2679	2679.0	64.12	64.1	Molecular chaperones in cellular protein folding.	F U Hartl	Nature	1996	8637592	No
567	5358	2679.0	0.0	0.0	A modified uronic acid carbazole reaction.	T Bitter, H M Muir	Anal Biochem	1962	13971270	Yes
568	2673	2673.0	52.36	52.4	Genome maintenance mechanisms for preventing cancer.	J H Hoeijmakers	Nature	2001	11357144	No
569	5345	2672.5	127.3	63.6	Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes.	F W Studier, B A Moffatt	J Mol Biol	1986	3537305	Yes
570	2671	2671.0	76.95	77.0	Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection.	Y X Fu	Genetics	1997	9335623	Yes
571	5336	2668.0	174.61	87.3	Tissue engineering.	R Langer, J P Vacanti	Science	1993	8493529	No
572	5321	2660.5	126.46	63.2	Oncomirs - microRNAs with a role in cancer.	Aurora Esquela-Kerscher, Frank J Slack	Nat Rev Cancer	2006	16557279	No
573	2656	2656.0	0.0	0.0	Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism.	P Mitchell	Nature	1961	13771349	Yes
574	5310	2655.0	132.25	66.1	In vitro selection of RNA molecules that bind specific ligands.	A D Ellington, J W Szostak	Nature	1990	1697402	Yes
575	2655	2655.0	52.28	52.3	Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling.	P Schuck	Biophys J	2000	10692345	Yes
576	2650	2650.0	124.54	124.5	The short-form McGill Pain Questionnaire.	Ronald Melzack	Pain	1987	3670870	Yes
577	2649	2649.0	86.55	86.5	Psychometric properties of the strengths and difficulties questionnaire.	R Goodman	J Am Acad Child Adolesc Psychiatry	2001	11699809	Yes
578	10584	2646.0	441.53	110.4	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	BMJ	2009	19622551	No
579	5284	2642.0	148.5	74.2	Fast and accurate long-read alignment with Burrows-Wheeler transform.	Heng Li, Richard Durbin	Bioinformatics	2010	20080505	Yes
580	7918	2639.3	205.31	68.4	TopHat: discovering splice junctions with RNA-Seq.	Cole Trapnell, Lior Pachter, Steven L Salzberg	Bioinformatics	2009	19289445	Yes
581	5265	2632.5	132.52	66.3	Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis.	D Hanahan, J Folkman	Cell	1996	8756718	No
582	2632	2632.0	0.0	0.0	Stereotaxic mapping of the monoamine pathways in the rat brain.	U Ungerstedt	Acta Physiol Scand Suppl	1971	4109331	Yes
583	5259	2629.5	164.4	82.2	Glutathione.	A Meister, M E Anderson	Annu Rev Biochem	1983	6137189	No
584	5253	2626.5	123.42	61.7	Oxidants, oxidative stress and the biology of ageing.	T Finkel, N J Holbrook	Nature	2000	11089981	No
585	2626	2626.0	0.0	0.0	A gene complex controlling segmentation in Drosophila.	E B Lewis	Nature	1978	103000	Yes
586	2625	2625.0	81.68	81.7	Primate models of movement disorders of basal ganglia origin.	M R DeLong	Trends Neurosci	1990	1695404	No
587	2624	2624.0	49.31	49.3	Wnt signaling and cancer.	P Polakis	Genes Dev	2000	10921899	No
588	2624	2624.0	0.0	0.0	The genetical structure of populations.	S Wright	Ann Eugen	1951	24540312	Yes
589	5242	2621.0	180.65	90.3	Measuring agreement in method comparison studies.	J M Bland, D G Altman	Stat Methods Med Res	1999	10501650	No
590	5242	2621.0	0.0	0.0	Some quantitative uses of drug antagonists.	O Arunlakshana, H O Schild	Br J Pharmacol Chemother	1959	13651579	Yes
591	2618	2618.0	0.0	0.0	A simple technique for demonstrating centromeric heterochromatin.	A T Sumner	Exp Cell Res	1972	4117921	Yes
592	15700	2616.7	635.34	105.9	Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support.	Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G Conde	J Biomed Inform	2009	18929686	Yes
593	10420	2605.0	230.23	57.6	Cluster analysis and display of genome-wide expression patterns.	M B Eisen, P T Spellman, P O Brown, D Botstein	Proc Natl Acad Sci U S A	1998	9843981	Yes
594	2604	2604.0	81.79	81.8	Estimation of metabolite concentrations from localized in vivo proton NMR spectra.	S W Provencher	Magn Reson Med	1993	8139448	Yes
595	5193	2596.5	182.87	91.4	A simple, rapid, and sensitive DNA assay procedure.	C Labarca, K Paigen	Anal Biochem	1980	6158890	Yes
596	2596	2596.0	61.92	61.9	TGFbeta in Cancer.	Joan Massagué	Cell	2008	18662538	No
597	2594	2594.0	0.0	0.0	The membrane actions of anesthetics and tranquilizers.	P Seeman	Pharmacol Rev	1972	4565956	No
598	2594	2594.0	60.15	60.1	Nuclear factor-kappaB in cancer development and progression.	Michael Karin	Nature	2006	16724054	No
599	12961	2592.2	524.5	104.9	The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research.	D J Buysse, C F Reynolds, T H Monk, S R Berman, D J Kupfer	Psychiatry Res	1989	2748771	Yes
600	2588	2588.0	82.63	82.6	Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.	B Samuelsson	Science	1983	6301011	Yes
601	7742	2580.7	216.33	72.1	Understanding the Warburg effect: the metabolic requirements of cell proliferation.	Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson	Science	2009	19460998	No
602	2578	2578.0	85.2	85.2	No adjustments are needed for multiple comparisons.	K J Rothman	Epidemiology	1990	2081237	Yes
603	5156	2578.0	186.5	93.2	A method of comparing the areas under receiver operating characteristic curves derived from the same cases.	J A Hanley, B J McNeil	Radiology	1983	6878708	Yes
604	7731	2577.0	261.42	87.1	Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases.	R A Deyo, D C Cherkin, M A Ciol	J Clin Epidemiol	1992	1607900	Yes
605	5153	2576.5	117.07	58.5	Signal transduction by receptors with tyrosine kinase activity.	A Ullrich, J Schlessinger	Cell	1990	2158859	No
606	23187	2576.3	657.09	73.0	The Sequence Alignment/Map format and SAMtools.	Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin	Bioinformatics	2009	19505943	Yes
607	5148	2574.0	106.38	53.2	Establishment in culture of pluripotential cells from mouse embryos.	M J Evans, M H Kaufman	Nature	1981	7242681	Yes
608	2573	2573.0	0.0	0.0	Analysis of gene diversity in subdivided populations.	M Nei	Proc Natl Acad Sci U S A	1973	4519626	Yes
609	2570	2570.0	45.78	45.8	Mechanisms underlying ubiquitination.	C M Pickart	Annu Rev Biochem	2001	11395416	No
610	2566	2566.0	0.0	0.0	The biology of oxygen radicals.	I Fridovich	Science	1978	210504	Yes
611	5132	2566.0	189.95	95.0	Longitudinal data analysis for discrete and continuous outcomes.	S L Zeger, K Y Liang	Biometrics	1986	3719049	Yes
612	2566	2566.0	59.58	59.6	Cell adhesion: the molecular basis of tissue architecture and morphogenesis.	B M Gumbiner	Cell	1996	8608588	No
613	2565	2565.0	0.0	0.0	The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.	R R Porter	Biochem J	1959	14434282	Yes
614	2565	2565.0	89.46	89.5	Essential oils: their antibacterial properties and potential applications in foods--a review.	Sara Burt	Int J Food Microbiol	2004	15246235	No
615	2564	2564.0	54.22	54.2	Papillomaviruses and cancer: from basic studies to clinical application.	Harald zur Hausen	Nat Rev Cancer	2002	12044010	No
616	2562	2562.0	64.41	64.4	The nerve growth factor 35 years later.	R Levi-Montalcini	Science	1987	3306916	No
617	2560	2560.0	60.08	60.1	Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays.	S A Bustin	J Mol Endocrinol	2000	11013345	No
618	2555	2555.0	0.0	0.0	Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults.	O Smithies	Biochem J	1955	13276348	Yes
619	5109	2554.5	0.0	0.0	Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.	L A Greene, A S Tischler	Proc Natl Acad Sci U S A	1976	1065897	Yes
620	2551	2551.0	119.88	119.9	Detecting alcoholism. The CAGE questionnaire.	J A Ewing	JAMA	1984	6471323	Yes
621	2551	2551.0	53.65	53.6	Interleukin-12 and the regulation of innate resistance and adaptive immunity.	Giorgio Trinchieri	Nat Rev Immunol	2003	12563297	No
622	2551	2551.0	52.56	52.6	Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses.	Shimon Sakaguchi	Annu Rev Immunol	2004	15032588	No
623	5090	2545.0	112.67	56.3	Emergence of scaling in random networks	Barabasi, Albert	Science	1999	10521342	Yes
624	2540	2540.0	62.57	62.6	Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity.	E C Butcher	Cell	1991	1760836	No
625	2540	2540.0	55.31	55.3	G1 phase progression: cycling on cue.	C J Sherr	Cell	1994	7954821	No
626	2539	2539.0	52.8	52.8	The danger model: a renewed sense of self.	Polly Matzinger	Science	2002	11951032	Yes
627	2534	2534.0	72.63	72.6	Delayed neuronal death in the gerbil hippocampus following ischemia.	T Kirino	Brain Res	1982	7093691	Yes
628	2528	2528.0	67.29	67.3	The resurgence of platinum-based cancer chemotherapy.	Lloyd Kelland	Nat Rev Cancer	2007	17625587	No
629	2526	2526.0	80.75	80.8	What are the functional consequences of neurocognitive deficits in schizophrenia?	M F Green	Am J Psychiatry	1996	8610818	No
630	7568	2522.7	296.25	98.8	Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups.	Allison Tong, Peter Sainsbury, Jonathan Craig	Int J Qual Health Care	2007	17872937	Yes
631	2518	2518.0	110.87	110.9	FreeSurfer.	Bruce Fischl	Neuroimage	2012	22248573	No
632	5033	2516.5	174.94	87.5	mTOR signaling in growth control and disease.	Mathieu Laplante, David M Sabatini	Cell	2012	22500797	No
633	5025	2512.5	0.0	0.0	Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent.	J Sedlak, R H Lindsay	Anal Biochem	1968	4973948	Yes
634	10050	2512.5	372.02	93.0	A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu.	Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge Krieg	J Chem Phys	2010	20423165	Yes
635	5024	2512.0	157.88	78.9	Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees.	K Tamura, M Nei	Mol Biol Evol	1993	8336541	Yes
636	7524	2508.0	173.34	57.8	The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.	R C Lee, R L Feinbaum, V Ambros	Cell	1993	8252621	Yes
637	2507	2507.0	77.73	77.7	Secretory products of macrophages.	C F Nathan	J Clin Invest	1987	3543052	No
638	5014	2507.0	105.35	52.7	Innate immune recognition.	Charles A Janeway, Ruslan Medzhitov	Annu Rev Immunol	2002	11861602	No
639	5013	2506.5	151.89	75.9	The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.	Taro Kawai, Shizuo Akira	Nat Immunol	2010	20404851	No
640	2501	2501.0	67.55	67.5	Predictive reward signal of dopamine neurons.	W Schultz	J Neurophysiol	1998	9658025	No
641	4999	2499.5	158.74	79.4	The L-arginine-nitric oxide pathway.	S Moncada, A Higgs	N Engl J Med	1993	7504210	No
642	2497	2497.0	0.0	0.0	Elastic properties of lipid bilayers: theory and possible experiments.	W Helfrich	Z Naturforsch C	1973	4273690	Yes
643	4992	2496.0	177.84	88.9	The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM.	Stephen B Edge, Carolyn C Compton	Ann Surg Oncol	2010	20180029	No
644	4986	2493.0	0.0	0.0	The Social Readjustment Rating Scale.	T H Holmes, R H Rahe	J Psychosom Res	1967	6059863	Yes
645	4982	2491.0	0.0	0.0	Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.	P J Fraker, J C Speck	Biochem Biophys Res Commun	1978	637870	Yes
646	4977	2488.5	0.0	0.0	A diagnostic interview: the schedule for affective disorders and schizophrenia.	J Endicott, R L Spitzer	Arch Gen Psychiatry	1978	678037	Yes
647	2488	2488.0	50.77	50.8	Universal control mechanism regulating onset of M-phase.	P Nurse	Nature	1990	2138713	No
648	2488	2488.0	60.36	60.4	Memory--a century of consolidation.	J L McGaugh	Science	2000	10634773	No
649	4976	2488.0	172.0	86.0	Computed tomography--an increasing source of radiation exposure.	David J Brenner, Eric J Hall	N Engl J Med	2007	18046031	No
650	2484	2484.0	0.0	0.0	On the number of segregating sites in genetical models without recombination.	G A Watterson	Theor Popul Biol	1975	1145509	Yes
651	2479	2479.0	0.0	0.0	The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin.	M L Anson	J Gen Physiol	1938	19873094	Yes
652	19822	2477.8	451.55	56.4	The Protein Data Bank.	H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E Bourne	Nucleic Acids Res	2000	10592235	Yes
653	2475	2475.0	0.0	0.0	Oxygen-dependent microbial killing by phagocytes (first of two parts).	B M Babior	N Engl J Med	1978	24176	Yes
654	4949	2474.5	133.72	66.9	Exploring the full spectrum of macrophage activation.	David M Mosser, Justin P Edwards	Nat Rev Immunol	2008	19029990	No
655	2468	2468.0	0.0	0.0	The catecholamine hypothesis of affective disorders: a review of supporting evidence.	J J Schildkraut	Am J Psychiatry	1965	5319766	No
656	2462	2462.0	0.0	0.0	Models for the specific adhesion of cells to cells.	G I Bell	Science	1978	347575	No
657	2461	2461.0	0.0	0.0	The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes.	S Boyden	J Exp Med	1962	13872176	Yes
658	2457	2457.0	58.36	58.4	Prostaglandins and leukotrienes: advances in eicosanoid biology.	C D Funk	Science	2001	11729303	No
659	7335	2445.0	222.57	74.2	Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study.	G Evanno, S Regnaut, J Goudet	Mol Ecol	2005	15969739	Yes
660	9774	2443.5	303.8	76.0	Establishing a standard definition for child overweight and obesity worldwide: international survey.	T J Cole, M C Bellizzi, K M Flegal, W H Dietz	BMJ	2000	10797032	Yes
661	4884	2442.0	108.97	54.5	Inflammation and cancer: back to Virchow?	F Balkwill, A Mantovani	Lancet	2001	11229684	No
662	2431	2431.0	55.32	55.3	Social controls on cell survival and cell death.	M C Raff	Nature	1992	1557121	No
663	4849	2424.5	197.36	98.7	A feature-integration theory of attention.	A M Treisman, G Gelade	Cogn Psychol	1980	7351125	Yes
664	2421	2421.0	93.72	93.7	Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM.	Joseph P Weir	J Strength Cond Res	2005	15705040	No
665	2420	2420.0	89.06	89.1	Measures of reliability in sports medicine and science.	W G Hopkins	Sports Med	2000	10907753	Yes
666	4833	2416.5	146.15	73.1	Adherence to medication.	Lars Osterberg, Terrence Blaschke	N Engl J Med	2005	16079372	No
667	4830	2415.0	157.91	79.0	Complex brain networks: graph theoretical analysis of structural and functional systems.	Ed Bullmore, Olaf Sporns	Nat Rev Neurosci	2009	19190637	No
668	2414	2414.0	68.29	68.3	Cellular and molecular mechanisms of fibrosis.	T A Wynn	J Pathol	2008	18161745	No
669	2411	2411.0	63.86	63.9	The genetic legacy of the Quaternary ice ages.	G Hewitt	Nature	2000	10879524	No
670	2408	2408.0	65.77	65.8	Dominant forces in protein folding.	K A Dill	Biochemistry	1990	2207096	No
671	2408	2408.0	54.44	54.4	Bone resorption by osteoclasts.	S L Teitelbaum	Science	2000	10968780	No
672	2405	2405.0	0.0	0.0	Perceived exertion as an indicator of somatic stress.	G Borg	Scand J Rehabil Med	1970	5523831	Yes
673	2403	2403.0	0.0	0.0	Transduction of linked genetic characters of the host by bacteriophage P1.	E S Lennox	Virology	1955	13267987	Yes
674	4805	2402.5	0.0	0.0	Electrochemical photolysis of water at a semiconductor electrode.	A Fujishima, K Honda	Nature	1972	12635268	Yes
675	2399	2399.0	92.94	92.9	You want to measure coping but your protocol's too long: consider the brief COPE.	C S Carver	Int J Behav Med	1997	16250744	Yes
676	4780	2390.0	0.0	0.0	Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years.	J V Durnin, J Womersley	Br J Nutr	1974	4843734	Yes
677	4778	2389.0	116.12	58.1	Calculation of protein extinction coefficients from amino acid sequence data.	S C Gill, P H von Hippel	Anal Biochem	1989	2610349	Yes
678	2387	2387.0	65.47	65.5	Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication.	H G Gratzner	Science	1982	7123245	Yes
679	2387	2387.0	0.0	0.0	Satellite cell of skeletal muscle fibers.	A Mauro	J Biophys Biochem Cytol	1961	13768451	Yes
680	2376	2376.0	0.0	0.0	Colorimetric assay of catalase.	A K Sinha	Anal Biochem	1972	4556490	Yes
681	7127	2375.7	177.4	59.1	Pathogen recognition and innate immunity.	Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi	Cell	2006	16497588	No
682	2373	2373.0	57.96	58.0	Autophagy: process and function.	Noboru Mizushima	Genes Dev	2007	18006683	No
683	4740	2370.0	157.59	78.8	The neural basis of drug craving: an incentive-sensitization theory of addiction.	T E Robinson, K C Berridge	Brain Res Brain Res Rev	1993	8401595	No
684	2368	2368.0	0.0	0.0	Electroimmuno assay.	C B Laurell	Scand J Clin Lab Invest Suppl	1972	4114358	Yes
685	2368	2368.0	57.76	57.8	Vascular endothelial growth factor: basic science and clinical progress.	Napoleone Ferrara	Endocr Rev	2004	15294883	No
686	2364	2364.0	0.0	0.0	A rapid radiochemical method for the determination of choline acetyltransferase.	F Fonnum	J Neurochem	1975	1113118	Yes
687	4728	2364.0	134.62	67.3	Unified segmentation.	John Ashburner, Karl J Friston	Neuroimage	2005	15955494	Yes
688	9456	2364.0	491.74	122.9	Cancer statistics, 2014.	Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin Jemal	CA Cancer J Clin	2014	24399786	Yes
689	4723	2361.5	97.38	48.7	Untangling the ErbB signalling network.	Y Yarden, M X Sliwkowski	Nat Rev Mol Cell Biol	2001	11252954	No
690	4720	2360.0	0.0	0.0	Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase.	S Marklund, G Marklund	Eur J Biochem	1974	4215654	Yes
691	4713	2356.5	94.91	47.5	CDK inhibitors: positive and negative regulators of G1-phase progression.	C J Sherr, J M Roberts	Genes Dev	1999	10385618	No
692	2351	2351.0	57.7	57.7	Epigenetics in cancer.	Manel Esteller	N Engl J Med	2008	18337604	No
693	2348	2348.0	61.48	61.5	Cancer nanotechnology: opportunities and challenges.	Mauro Ferrari	Nat Rev Cancer	2005	15738981	No
694	4695	2347.5	0.0	0.0	Screening lambdagt recombinant clones by hybridization to single plaques in situ.	W D Benton, R W Davis	Science	1977	322279	Yes
695	4693	2346.5	0.0	0.0	A general method applicable to the search for similarities in the amino acid sequence of two proteins.	S B Needleman, C D Wunsch	J Mol Biol	1970	5420325	Yes
696	2339	2339.0	56.34	56.3	Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface.	G P Smith	Science	1985	4001944	Yes
697	2336	2336.0	0.0	0.0	The glomerular permeability determined by dextran clearance using Sephadex gel filtration.	C E Mogensen	Scand J Clin Lab Invest	1968	5637478	Yes
698	2336	2336.0	72.04	72.0	RELION: implementation of a Bayesian approach to cryo-EM structure determination.	Sjors H W Scheres	J Struct Biol	2012	23000701	Yes
699	4656	2328.0	0.0	0.0	Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography.	R A Laskey, A D Mills	Eur J Biochem	1975	1175627	Yes
700	4656	2328.0	0.0	0.0	Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid.	J D Watson, F H Crick	Nature	1953	13054692	Yes
701	2326	2326.0	54.11	54.1	Salt and drought stress signal transduction in plants.	Jian-Kang Zhu	Annu Rev Plant Biol	2002	12221975	No
702	4651	2325.5	119.13	59.6	Autophagy in the pathogenesis of disease.	Beth Levine, Guido Kroemer	Cell	2008	18191218	No
703	2320	2320.0	45.56	45.6	Getting started with yeast.	F Sherman	Methods Enzymol	1991	2005794	Yes
704	2318	2318.0	85.9	85.9	Calmodulin plays a pivotal role in cellular regulation.	W Y Cheung	Science	1980	6243188	No
705	4629	2314.5	100.17	50.1	MicroRNAs: small RNAs with a big role in gene regulation.	Lin He, Gregory J Hannon	Nat Rev Genet	2004	15211354	No
706	2314	2314.0	0.0	0.0	Application of a microtechnique to viral serological investigations.	J L Sever	J Immunol	1962	13910995	Yes
707	4628	2314.0	211.34	105.7	The qualitative content analysis process.	Satu Elo, Helvi Kyngäs	J Adv Nurs	2008	18352969	Yes
708	2314	2314.0	89.85	89.8	What is value in health care?	Michael E Porter	N Engl J Med	2010	21142528	Yes
709	4626	2313.0	0.0	0.0	Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion.	J Silness, H Loe	Acta Odontol Scand	1964	14158464	Yes
710	2308	2308.0	51.38	51.4	Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling.	T Hunter	Cell	1995	7834742	No
711	2308	2308.0	54.19	54.2	Angiogenesis in life, disease and medicine.	Peter Carmeliet	Nature	2005	16355210	No
712	2303	2303.0	0.0	0.0	The Michigan alcoholism screening test: the quest for a new diagnostic instrument.	M L Selzer	Am J Psychiatry	1971	5565851	Yes
713	2303	2303.0	53.8	53.8	A decade of molecular biology of retinoic acid receptors.	P Chambon	FASEB J	1996	8801176	No
714	4603	2301.5	235.34	117.7	GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update.	Rod Peakall, Peter E Smouse	Bioinformatics	2012	22820204	Yes
715	2296	2296.0	0.0	0.0	Inositol phospholipids and cell surface receptor function.	R H Michell	Biochim Biophys Acta	1975	164246	No
716	2294	2294.0	0.0	0.0	Separation of leukocytes from blood and bone marrow. Introduction.	A Böyum	Scand J Clin Lab Invest Suppl	1968	5707208	Yes
717	2291	2291.0	51.69	51.7	The structure and regulation of protein phosphatases.	P Cohen	Annu Rev Biochem	1989	2549856	No
718	2291	2291.0	57.57	57.6	Bcl-2 and the regulation of programmed cell death.	J C Reed	J Cell Biol	1994	8294493	No
719	2290	2290.0	66.3	66.3	Interleukin-1 and interleukin-1 antagonism.	C A Dinarello	Blood	1991	1826616	No
720	4576	2288.0	104.62	52.3	Death receptors: signaling and modulation.	A Ashkenazi, V M Dixit	Science	1998	9721089	No
721	2285	2285.0	50.35	50.4	Evolving concepts of rheumatoid arthritis.	Gary S Firestein	Nature	2003	12748655	No
722	4561	2280.5	0.0	0.0	High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.	M N Berry, D S Friend	J Cell Biol	1969	4900611	Yes
723	2278	2278.0	62.69	62.7	The magical number 4 in short-term memory: a reconsideration of mental storage capacity.	N Cowan	Behav Brain Sci	2001	11515286	Yes
724	2278	2278.0	0.0	0.0	Muscle structure and theories of contraction.	A F Huxley	Prog Biophys Biophys Chem	1957	13485191	Yes
725	4549	2274.5	163.04	81.5	Complex network measures of brain connectivity: uses and interpretations.	Mikail Rubinov, Olaf Sporns	Neuroimage	2010	19819337	Yes
726	6821	2273.7	136.7	45.6	Gene Expression Omnibus: NCBI gene expression and hybridization array data repository.	Ron Edgar, Michael Domrachev, Alex E Lash	Nucleic Acids Res	2002	11752295	Yes
727	2269	2269.0	66.65	66.7	Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention.	P Correa	Cancer Res	1992	1458460	No
728	2269	2269.0	95.33	95.3	The Danish Civil Registration System.	Carsten Bøcker Pedersen	Scand J Public Health	2011	21775345	Yes
729	2266	2266.0	45.73	45.7	SV40-transformed simian cells support the replication of early SV40 mutants.	Y Gluzman	Cell	1981	6260373	Yes
730	2263	2263.0	95.46	95.5	Qualitative research. Introducing focus groups.	J Kitzinger	BMJ	1995	7633241	Yes
731	2261	2261.0	56.29	56.3	Calcium signaling.	David E Clapham	Cell	2007	18083096	No
732	2257	2257.0	76.46	76.5	Glutamate, nitric oxide and cell-cell signalling in the nervous system.	J Garthwaite	Trends Neurosci	1991	1708538	No
733	2253	2253.0	76.74	76.7	Accelerated Profile HMM Searches.	Sean R Eddy	PLoS Comput Biol	2011	22039361	Yes
734	2251	2251.0	56.06	56.1	MapChart: software for the graphical presentation of linkage maps and QTLs.	R E Voorrips	J Hered	2002	12011185	Yes
735	2249	2249.0	0.0	0.0	Stereochemistry of cooperative effects in haemoglobin.	M F Perutz	Nature	1970	5528785	Yes
736	4495	2247.5	140.73	70.4	Rapid isolation of high molecular weight plant DNA.	M G Murray, W F Thompson	Nucleic Acids Res	1980	7433111	Yes
737	6742	2247.3	0.0	0.0	On The Nature Of Allosteric Transitions: A Plausible Model.	J Monod, J Wyman, J P Changeux	J Mol Biol	1965	14343300	Yes
738	2245	2245.0	47.24	47.2	Tumour-educated macrophages promote tumour progression and metastasis.	Jeffrey W Pollard	Nat Rev Cancer	2004	14708027	No
739	4488	2244.0	103.05	51.5	A simple and very efficient method for generating cDNA libraries.	U Gubler, B J Hoffman	Gene	1983	6198242	Yes
740	4488	2244.0	91.19	45.6	The phosphatidylinositol 3-Kinase AKT pathway in human cancer.	Igor Vivanco, Charles L Sawyers	Nat Rev Cancer	2002	12094235	No
741	4487	2243.5	94.06	47.0	Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.	D Bonnet, J E Dick	Nat Med	1997	9212098	Yes
742	2241	2241.0	0.0	0.0	Evaluating the quality of medical care.	A Donabedian	Milbank Mem Fund Q	1966	5338568	No
743	4478	2239.0	117.64	58.8	Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences.	Weizhong Li, Adam Godzik	Bioinformatics	2006	16731699	Yes
744	4474	2237.0	91.91	46.0	Lipid rafts and signal transduction.	K Simons, D Toomre	Nat Rev Mol Cell Biol	2000	11413487	No
745	2236	2236.0	51.66	51.7	Mitochondrial diseases in man and mouse.	D C Wallace	Science	1999	10066162	No
746	4462	2231.0	85.08	42.5	A novel genetic system to detect protein-protein interactions.	S Fields, O Song	Nature	1989	2547163	Yes
747	4458	2229.0	123.4	61.7	Management of hepatocellular carcinoma.	Jordi Bruix, Morris Sherman	Hepatology	2005	16250051	No
748	2223	2223.0	55.14	55.1	Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose.	J Kyhse-Andersen	J Biochem Biophys Methods	1984	6530509	Yes
749	2221	2221.0	56.05	56.0	A model for receptor-regulated calcium entry.	J W Putney	Cell Calcium	1986	2420465	No
750	2220	2220.0	0.0	0.0	Removal of fatty acids from serum albumin by charcoal treatment.	R F Chen	J Biol Chem	1967	6016603	Yes
751	2219	2219.0	0.0	0.0	The information capacity of the human motor system in controlling the amplitude of movement.	P M Fitts	J Exp Psychol	1954	13174710	Yes
752	2218	2218.0	71.26	71.3	Reactive oxygen species and the central nervous system.	B Halliwell	J Neurochem	1992	1402908	No
753	4436	2218.0	99.75	49.9	Organization and expression of eucaryotic split genes coding for proteins.	R Breathnach, P Chambon	Annu Rev Biochem	1981	6791577	No
754	2218	2218.0	53.4	53.4	Mechanisms and genes of cellular suicide.	H Steller	Science	1995	7878463	No
755	2216	2216.0	0.0	0.0	Mechanisms of action of transmitters and other substances on smooth muscle.	T B Bolton	Physiol Rev	1979	37533	No
756	4432	2216.0	0.0	0.0	The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin.	J A Spudich, S Watt	J Biol Chem	1971	4254541	Yes
757	2213	2213.0	50.1	50.1	Chemokines and leukocyte traffic.	M Baggiolini	Nature	1998	9560152	No
758	2211	2211.0	59.01	59.0	A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.	P Chomczynski	Biotechniques	1993	7692896	Yes
759	2210	2210.0	58.54	58.5	Causes and consequences of microRNA dysregulation in cancer.	Carlo M Croce	Nat Rev Genet	2009	19763153	No
760	2209	2209.0	49.3	49.3	Molecular physiology of P2X receptors.	R Alan North	Physiol Rev	2002	12270951	No
761	2207	2207.0	85.35	85.3	Role of endothelium in responses of vascular smooth muscle.	R F Furchgott	Circ Res	1983	6313250	No
762	6618	2206.0	368.2	122.7	Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition.	P J Van Soest, J B Robertson, B A Lewis	J Dairy Sci	1991	1660498	No
763	2206	2206.0	53.47	53.5	Protein kinase C and lipid signaling for sustained cellular responses.	Y Nishizuka	FASEB J	1995	7737456	No
764	4412	2206.0	120.7	60.4	Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology.	Marie-Christine Daniel, Didier Astruc	Chem Rev	2004	14719978	No
765	2205	2205.0	61.78	61.8	Molecular diversity of glutamate receptors and implications for brain function.	S Nakanishi	Science	1992	1329206	No
766	2205	2205.0	70.3	70.3	SF-36 health survey update.	J E Ware	Spine (Phila Pa 1976)	2000	11124729	No
767	2203	2203.0	72.62	72.6	adegenet: a R package for the multivariate analysis of genetic markers.	Thibaut Jombart	Bioinformatics	2008	18397895	Yes
768	2201	2201.0	66.03	66.0	Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century.	M Leavitt	MedGenMed	2001	11549951	No
769	4398	2199.0	0.0	0.0	The interpretation of protein structures: estimation of static accessibility.	B Lee, F M Richards	J Mol Biol	1971	5551392	Yes
770	2199	2199.0	78.62	78.6	Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases.	B N Ames	Science	1983	6351251	No
771	2197	2197.0	0.0	0.0	[Rapid physiological coagulation method in determination of fibrinogen].	A Clauss	Acta Haematol	1957	13434757	Yes
772	4392	2196.0	0.0	0.0	On the size of the active site in proteases. I. Papain.	I Schechter, A Berger	Biochem Biophys Res Commun	1967	6035483	Yes
773	4379	2189.5	115.56	57.8	A receptor-mediated pathway for cholesterol homeostasis.	M S Brown, J L Goldstein	Science	1986	3513311	No
774	2188	2188.0	56.53	56.5	Molecular basis of bacterial outer membrane permeability revisited.	Hiroshi Nikaido	Microbiol Mol Biol Rev	2003	14665678	No
775	4369	2184.5	220.76	110.4	Stress, social support, and the buffering hypothesis.	S Cohen, T A Wills	Psychol Bull	1985	3901065	No
776	4368	2184.0	0.0	0.0	A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.	J E TILL, E A McCULLOCH	Radiat Res	1961	13776896	Yes
777	2184	2184.0	119.85	119.8	Interrater reliability: the kappa statistic.	Mary L McHugh	Biochem Med (Zagreb)	2012	23092060	Yes
778	4366	2183.0	0.0	0.0	Periodontal Disease In Pregnancy. I. Prevalence And Severity.	H Loe, J Silness	Acta Odontol Scand	1963	14121956	Yes
779	2183	2183.0	79.62	79.6	A computational approach to edge detection.	J Canny	IEEE Trans Pattern Anal Mach Intell	1986	21869365	Yes
780	2182	2182.0	68.23	68.2	Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.	R A DeFronzo	Diabetes	1988	3289989	No
781	2181	2181.0	68.11	68.1	Prooxidant states and tumor promotion.	P A Cerutti	Science	1985	2981433	No
782	4353	2176.5	95.69	47.8	New functions for the matrix metalloproteinases in cancer progression.	Mikala Egeblad, Zena Werb	Nat Rev Cancer	2002	11990853	No
783	2176	2176.0	0.0	0.0	A new specific color reaction of hexuronic acids.	Z Dische	J Biol Chem	1947	20281638	Yes
784	4344	2172.0	148.49	74.2	Random-effects models for longitudinal data.	N M Laird, J H Ware	Biometrics	1982	7168798	Yes
785	4344	2172.0	141.56	70.8	Accurate and simple analytic representation of the electron-gas correlation energy.	Perdew, Wang	Phys Rev B Condens Matter	1992	10001404	Yes
786	2171	2171.0	65.47	65.5	Two-sided confidence intervals for the single proportion: comparison of seven methods.	R G Newcombe	Stat Med	1998	9595616	Yes
787	2171	2171.0	53.93	53.9	Ischemic cell death in brain neurons.	P Lipton	Physiol Rev	1999	10508238	No
788	4331	2165.5	446.97	223.5	A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research.	Terry K Koo, Mae Y Li	J Chiropr Med	2016	27330520	Yes
789	4322	2161.0	128.88	64.4	Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9167458	Yes
790	2158	2158.0	58.22	58.2	Dietary pattern analysis: a new direction in nutritional epidemiology.	Frank B Hu	Curr Opin Lipidol	2002	11790957	No
791	2157	2157.0	48.41	48.4	The regulation of AP-1 activity by mitogen-activated protein kinases.	M Karin	J Biol Chem	1995	7622446	No
792	2157	2157.0	0.0	0.0	A Rationale And Test For The Number Of Factors In Factor Analysis.	J L Horn	Psychometrika	1965	14306381	Yes
793	2155	2155.0	0.0	0.0	Sedimentation Studies Of The Size And Shape Of Dna.	F W Studier	J Mol Biol	1965	14290352	Yes
794	12922	2153.7	319.19	53.2	Phaser crystallographic software.	Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J Read	J Appl Crystallogr	2007	19461840	Yes
795	2153	2153.0	49.28	49.3	Chemokines.	B J Rollins	Blood	1997	9242519	No
796	2152	2152.0	0.0	0.0	The plasma lecithins:cholesterol acyltransferase reaction.	J A Glomset	J Lipid Res	1968	4868699	No
797	2151	2151.0	79.84	79.8	Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals.	H W Steinbusch	Neuroscience	1981	7017455	Yes
798	2150	2150.0	66.29	66.3	Diagnosis of Alzheimer's disease.	Z S Khachaturian	Arch Neurol	1985	2864910	Yes
799	4299	2149.5	127.64	63.8	Pattern recognition receptors and inflammation.	Osamu Takeuchi, Shizuo Akira	Cell	2010	20303872	No
800	2149	2149.0	42.02	42.0	Java Treeview--extensible visualization of microarray data.	Alok J Saldanha	Bioinformatics	2004	15180930	Yes
801	6445	2148.3	209.19	69.7	Arlequin (version 3.0): an integrated software package for population genetics data analysis.	Laurent Excoffier, Guillaume Laval, Stefan Schneider	Evol Bioinform Online	2007	19325852	Yes
802	4293	2146.5	168.16	84.1	FLASH: fast length adjustment of short reads to improve genome assemblies.	Tanja Magoč, Steven L Salzberg	Bioinformatics	2011	21903629	Yes
803	2144	2144.0	0.0	0.0	The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations.	W W Cleland	Biochim Biophys Acta	1963	14021667	Yes
804	4286	2143.0	96.07	48.0	Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.	F Sallusto, A Lanzavecchia	J Exp Med	1994	8145033	Yes
805	4285	2142.5	131.17	65.6	Neural mechanisms of selective visual attention.	R Desimone, J Duncan	Annu Rev Neurosci	1995	7605061	No
806	4282	2141.0	0.0	0.0	The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase.	H P Misra, I Fridovich	J Biol Chem	1972	4623845	Yes
807	4282	2141.0	99.74	49.9	The Bcl-2 protein family: arbiters of cell survival.	J M Adams, S Cory	Science	1998	9735050	No
808	6421	2140.3	150.85	50.3	The biology of VEGF and its receptors.	Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter	Nat Med	2003	12778165	No
809	4271	2135.5	117.15	58.6	Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up.	C W Elston, I O Ellis	Histopathology	1991	1757079	Yes
810	2135	2135.0	86.01	86.0	Effective physician-patient communication and health outcomes: a review.	M A Stewart	CMAJ	1995	7728691	Yes
811	2134	2134.0	125.08	125.1	Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs.	Daniël Lakens	Front Psychol	2013	24324449	No
812	8533	2133.2	279.34	69.8	Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy.	Qiong Wang, George M Garrity, James M Tiedje, James R Cole	Appl Environ Microbiol	2007	17586664	Yes
813	2130	2130.0	41.27	41.3	Histone acetylation in chromatin structure and transcription.	M Grunstein	Nature	1997	9311776	No
814	4251	2125.5	195.05	97.5	Clinical significance: a statistical approach to defining meaningful change in psychotherapy research.	N S Jacobson, P Truax	J Consult Clin Psychol	1991	2002127	Yes
815	4251	2125.5	0.0	0.0	A Simplified Lead Citrate Stain For Use In Electron Microscopy.	J H Venable, R Coggeshall	J Cell Biol	1965	14287192	Yes
816	2124	2124.0	41.35	41.4	Targeting RAS signalling pathways in cancer therapy.	Julian Downward	Nat Rev Cancer	2003	12509763	No
817	2123	2123.0	63.92	63.9	Scaffolds in tissue engineering bone and cartilage.	D W Hutmacher	Biomaterials	2000	11071603	Yes
818	2122	2122.0	0.0	0.0	Intracellular aspects of the process of protein synthesis.	G Palade	Science	1975	1096303	No
819	2122	2122.0	46.3	46.3	Telomere measurement by quantitative PCR.	Richard M Cawthon	Nucleic Acids Res	2002	12000852	Yes
820	2121	2121.0	41.95	42.0	Protein modules and signalling networks.	T Pawson	Nature	1995	7531822	No
821	2121	2121.0	49.68	49.7	A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine.	Douglas C Wallace	Annu Rev Genet	2005	16285865	No
822	6361	2120.3	189.88	63.3	Bacterial biofilms: a common cause of persistent infections.	J W Costerton, P S Stewart, E P Greenberg	Science	1999	10334980	No
823	6361	2120.3	372.46	124.2	Deep learning.	Yann LeCun, Yoshua Bengio, Geoffrey Hinton	Nature	2015	26017442	No
824	2113	2113.0	0.0	0.0	Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids.	D Aminoff	Biochem J	1961	13860975	Yes
825	6332	2110.7	289.34	96.4	Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale.	J L Cox, J M Holden, R Sagovsky	Br J Psychiatry	1987	3651732	Yes
826	2109	2109.0	80.11	80.1	Specific impairments of planning.	T Shallice	Philos Trans R Soc Lond B Biol Sci	1982	6125971	Yes
827	4214	2107.0	102.39	51.2	Signal integration in the endoplasmic reticulum unfolded protein response.	David Ron, Peter Walter	Nat Rev Mol Cell Biol	2007	17565364	No
828	4212	2106.0	107.19	53.6	Function and activation of NF-kappa B in the immune system.	P A Baeuerle, T Henkel	Annu Rev Immunol	1994	8011280	No
829	2105	2105.0	53.33	53.3	Modularity and community structure in networks.	M E J Newman	Proc Natl Acad Sci U S A	2006	16723398	Yes
830	4209	2104.5	105.5	52.8	Regulation of the mevalonate pathway.	J L Goldstein, M S Brown	Nature	1990	1967820	No
831	2104	2104.0	64.1	64.1	Physiology and neurobiology of stress and adaptation: central role of the brain.	Bruce S McEwen	Physiol Rev	2007	17615391	No
832	4206	2103.0	0.0	0.0	Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method.	R B Devereux, N Reichek	Circulation	1977	138494	Yes
833	4206	2103.0	149.87	74.9	The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions.	S H Downs, N Black	J Epidemiol Community Health	1998	9764259	Yes
834	4205	2102.5	94.65	47.3	Mass spectrometry-based proteomics.	Ruedi Aebersold, Matthias Mann	Nature	2003	12634793	No
835	2102	2102.0	50.12	50.1	Patterns of amino acids near signal-sequence cleavage sites.	G von Heijne	Eur J Biochem	1983	6852022	Yes
836	2102	2102.0	64.7	64.7	A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data.	Heng Li	Bioinformatics	2011	21903627	Yes
837	2100	2100.0	88.49	88.5	A systematic method for clinical description and classification of personality variants. A proposal.	C R Cloninger	Arch Gen Psychiatry	1987	3579504	Yes
838	8398	2099.5	246.15	61.5	GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation.	Berk Hess, Carsten Kutzner, David van der Spoel, Erik Lindahl	J Chem Theory Comput	2008	26620784	Yes
839	2098	2098.0	50.29	50.3	Specification of cerebral cortical areas.	P Rakic	Science	1988	3291116	No
840	4195	2097.5	100.33	50.2	Assembly of asparagine-linked oligosaccharides.	R Kornfeld, S Kornfeld	Annu Rev Biochem	1985	3896128	No
841	2094	2094.0	0.0	0.0	The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers.	D E Atkinson	Biochemistry	1968	4972613	Yes
842	4187	2093.5	85.95	43.0	Mechanisms of TGF-beta signaling from cell membrane to the nucleus.	Yigong Shi, Joan Massagué	Cell	2003	12809600	No
843	4183	2091.5	0.0	0.0	Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.	T V Bliss, T Lomo	J Physiol	1973	4727084	Yes
844	2091	2091.0	47.12	47.1	NOX enzymes and the biology of reactive oxygen.	J David Lambeth	Nat Rev Immunol	2004	15039755	No
845	2089	2089.0	43.33	43.3	The molecular biology of memory storage: a dialogue between genes and synapses.	E R Kandel	Science	2001	11691980	No
846	4176	2088.0	122.61	61.3	Distributed hierarchical processing in the primate cerebral cortex.	D J Felleman, D C Van Essen	Cereb Cortex	1991	1822724	No
847	4176	2088.0	154.24	77.1	The attention system of the human brain.	M I Posner, S E Petersen	Annu Rev Neurosci	1990	2183676	No
848	2087	2087.0	49.35	49.4	Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity.	G Trinchieri	Annu Rev Immunol	1995	7612223	No
849	4167	2083.5	120.89	60.4	Angiogenic factors.	J Folkman, M Klagsbrun	Science	1987	2432664	No
850	4167	2083.5	214.47	107.2	phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data.	Paul J McMurdie, Susan Holmes	PLoS One	2013	23630581	Yes
851	2082	2082.0	44.68	44.7	Mammalian G1 cyclins.	C J Sherr	Cell	1993	8513492	No
852	6236	2078.7	0.0	0.0	Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.	B N Ames, J Mccann, E Yamasaki	Mutat Res	1975	768755	Yes
853	16624	2078.0	541.92	67.7	The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.	D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C Siebert	N Engl J Med	1993	8366922	Yes
854	2076	2076.0	0.0	0.0	Method For Assay Of Intestinal Disaccharidases.	A Dahlqvist	Anal Biochem	1964	14106916	Yes
855	4151	2075.5	107.47	53.7	Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results.	E Lander, L Kruglyak	Nat Genet	1995	7581446	Yes
856	4151	2075.5	123.08	61.5	Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly.	J S Beckman, W H Koppenol	Am J Physiol	1996	8944624	No
857	2071	2071.0	0.0	0.0	Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters.	F F Jöbsis	Science	1977	929199	Yes
858	2070	2070.0	46.19	46.2	Cisplatin: mode of cytotoxic action and molecular basis of resistance.	Zahid H Siddik	Oncogene	2003	14576837	No
859	2070	2070.0	57.99	58.0	Immunological and inflammatory functions of the interleukin-1 family.	Charles A Dinarello	Annu Rev Immunol	2009	19302047	No
860	6198	2066.0	145.63	48.5	MOLMOL: a program for display and analysis of macromolecular structures.	R Koradi, M Billeter, K Wüthrich	J Mol Graph	1996	8744573	Yes
861	2066	2066.0	53.96	54.0	A mechanism for cognitive dynamics: neuronal communication through neuronal coherence.	Pascal Fries	Trends Cogn Sci	2005	16150631	No
862	2063	2063.0	63.3	63.3	The unbiased estimation of number and sizes of arbitrary particles using the disector.	D C Sterio	J Microsc	1984	6737468	Yes
863	2063	2063.0	0.0	0.0	Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane.	J C Skou	Physiol Rev	1965	14337569	No
864	4125	2062.5	158.31	79.2	Self-rated health and mortality: a review of twenty-seven community studies.	E L Idler, Y Benyamini	J Health Soc Behav	1997	9097506	No
865	4125	2062.5	108.61	54.3	Reactive oxygen species: metabolism, oxidative stress, and signal transduction.	Klaus Apel, Heribert Hirt	Annu Rev Plant Biol	2004	15377225	No
866	2062	2062.0	0.0	0.0	Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants.	J W Littlefield	Science	1964	14168277	Yes
867	2057	2057.0	51.3	51.3	The anatomy and taxonomy of protein structure.	J S Richardson	Adv Protein Chem	1981	7020376	No
868	2056	2056.0	53.75	53.8	Breast cancer and hormone-replacement therapy in the Million Women Study.	Valerie Beral	Lancet	2003	12927427	Yes
869	4109	2054.5	87.57	43.8	A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.	G Shaw, R Kamen	Cell	1986	3488815	Yes
870	6159	2053.0	181.47	60.5	Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.	C E Murry, R B Jennings, K A Reimer	Circulation	1986	3769170	Yes
871	4101	2050.5	0.0	0.0	Plaque formation and isolation of pure lines with poliomyelitis viruses.	R Dulbecco, M Vogt	J Exp Med	1954	13130792	Yes
872	4101	2050.5	104.2	52.1	Protein misfolding, functional amyloid, and human disease.	Fabrizio Chiti, Christopher M Dobson	Annu Rev Biochem	2006	16756495	No
873	2050	2050.0	0.0	0.0	Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices.	T Higuchi	J Pharm Sci	1963	14088963	Yes
874	6136	2045.3	172.11	57.4	RNA-Seq: a revolutionary tool for transcriptomics.	Zhong Wang, Mark Gerstein, Michael Snyder	Nat Rev Genet	2009	19015660	No
875	4090	2045.0	128.78	64.4	Missing data: our view of the state of the art.	Joseph L Schafer, John W Graham	Psychol Methods	2002	12090408	Yes
876	2045	2045.0	0.0	0.0	Isolation by Distance.	S Wright	Genetics	1943	17247074	Yes
877	4087	2043.5	98.52	49.3	AKT/PKB signaling: navigating downstream.	Brendan D Manning, Lewis C Cantley	Cell	2007	17604717	No
878	6119	2039.7	0.0	0.0	Immunochemical quantitation of antigens by single radial immunodiffusion.	G Mancini, A O Carbonara, J F Heremans	Immunochemistry	1965	4956917	Yes
879	4077	2038.5	107.78	53.9	Acute-phase proteins and other systemic responses to inflammation.	C Gabay, I Kushner	N Engl J Med	1999	9971870	No
880	2036	2036.0	77.05	77.0	DNA methylation age of human tissues and cell types.	Steve Horvath	Genome Biol	2013	24138928	Yes
881	2035	2035.0	42.73	42.7	G1 events and regulation of cell proliferation.	A B Pardee	Science	1989	2683075	No
882	2035	2035.0	64.11	64.1	Parkinson's disease: clinical features and diagnosis.	J Jankovic	J Neurol Neurosurg Psychiatry	2008	18344392	No
883	2033	2033.0	67.98	68.0	Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples.	Peter C Austin	Stat Med	2009	19757444	Yes
884	2031	2031.0	52.3	52.3	RGD and other recognition sequences for integrins.	E Ruoslahti	Annu Rev Cell Dev Biol	1996	8970741	No
885	2029	2029.0	69.24	69.2	A classification of glycosyl hydrolases based on amino acid sequence similarities.	B Henrissat	Biochem J	1991	1747104	Yes
886	4056	2028.0	100.17	50.1	Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction.	P Liang, A B Pardee	Science	1992	1354393	Yes
887	2027	2027.0	0.0	0.0	Antigen-antibody reactions in gels.	O Ouchterlony	Acta Pathol Microbiol Scand	1949	18143039	Yes
888	6078	2026.0	0.0	0.0	Glucose clamp technique: a method for quantifying insulin secretion and resistance.	R A DeFronzo, J D Tobin, R Andres	Am J Physiol	1979	382871	Yes
889	4050	2025.0	105.78	52.9	A global optimisation method for robust affine registration of brain images.	M Jenkinson, S Smith	Med Image Anal	2001	11516708	Yes
890	2022	2022.0	0.0	0.0	Analysis of bacteriophage T7 early RNAs and proteins on slab gels.	F W Studier	J Mol Biol	1973	4760132	Yes
891	2021	2021.0	69.96	70.0	Ethical authorship and publishing.	Andrew J S Coats	Int J Cardiol	2009	19046787	No
892	2020	2020.0	59.36	59.4	ATP-regulated K+ channels in cardiac muscle.	A Noma	Nature	1983	6310409	Yes
893	2020	2020.0	82.93	82.9	A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992.	E L Bradley	Arch Surg	1993	8489394	No
894	4040	2020.0	134.27	67.1	Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being.	R M Ryan, E L Deci	Am Psychol	2000	11392867	Yes
895	2018	2018.0	60.93	60.9	Stress, adaptation, and disease. Allostasis and allostatic load.	B S McEwen	Ann N Y Acad Sci	1998	9629234	No
896	2016	2016.0	48.09	48.1	Interleukin-2: inception, impact, and implications.	K A Smith	Science	1988	3131876	No
897	6047	2015.7	179.4	59.8	Quantum mechanical continuum solvation models.	Jacopo Tomasi, Benedetta Mennucci, Roberto Cammi	Chem Rev	2005	16092826	Yes
898	4027	2013.5	81.12	40.6	The fundamental role of epigenetic events in cancer.	Peter A Jones, Stephen B Baylin	Nat Rev Genet	2002	12042769	No
899	2013	2013.0	68.2	68.2	Working memory.	A Baddeley	Science	1992	1736359	No
900	2013	2013.0	59.78	59.8	Formation and Structure of Self-Assembled Monolayers.	Abraham Ulman	Chem Rev	1996	11848802	Yes
901	4023	2011.5	110.11	55.1	The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.	Karen Bedard, Karl-Heinz Krause	Physiol Rev	2007	17237347	No
902	2011	2011.0	57.23	57.2	Superoxide radical and superoxide dismutases.	I Fridovich	Annu Rev Biochem	1995	7574505	No
903	2011	2011.0	45.5	45.5	Nitric oxide and the immune response.	C Bogdan	Nat Immunol	2001	11577346	No
904	2009	2009.0	67.26	67.3	Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men.	W A Craig	Clin Infect Dis	1998	9455502	No
905	2007	2007.0	43.1	43.1	Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self.	Shimon Sakaguchi	Nat Immunol	2005	15785760	No
906	2007	2007.0	94.9	94.9	Structural Model Evaluation and Modification: An Interval Estimation Approach.	J H Steiger	Multivariate Behav Res	1990	26794479	Yes
907	2003	2003.0	44.56	44.6	Structural design and molecular evolution of a cytokine receptor superfamily.	J F Bazan	Proc Natl Acad Sci U S A	1990	2169613	Yes
908	1999	1999.0	0.0	0.0	Presidential Address-1976. Social support as a moderator of life stress.	S Cobb	Psychosom Med	1976	981490	Yes
909	3991	1995.5	127.62	63.8	SPSS and SAS procedures for estimating indirect effects in simple mediation models.	Kristopher J Preacher, Andrew F Hayes	Behav Res Methods Instrum Comput	2004	15641418	Yes
910	1995	1995.0	47.79	47.8	Calcium signaling.	D E Clapham	Cell	1995	7834745	No
911	1995	1995.0	45.31	45.3	Complement. First of two parts.	M J Walport	N Engl J Med	2001	11287977	No
912	1994	1994.0	42.89	42.9	XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density.	D E McRee	J Struct Biol	1999	10222271	Yes
913	5980	1993.3	165.36	55.1	ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data.	Kai Wang, Mingyao Li, Hakon Hakonarson	Nucleic Acids Res	2010	20601685	Yes
914	1992	1992.0	0.0	0.0	Chemiosmotic coupling in oxidative and photosynthetic phosphorylation.	P Mitchell	Biol Rev Camb Philos Soc	1966	5329743	No
915	1991	1991.0	0.0	0.0	The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis.	U E Loening	Biochem J	1967	5339944	Yes
916	3981	1990.5	80.33	40.2	Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.	M Gossen, H Bujard	Proc Natl Acad Sci U S A	1992	1319065	Yes
917	1989	1989.0	83.29	83.3	Role of Streptococcus mutans in human dental decay.	W J Loesche	Microbiol Rev	1986	3540569	No
918	1989	1989.0	67.03	67.0	Biodiesel from microalgae.	Yusuf Chisti	Biotechnol Adv	2007	17350212	No
919	3975	1987.5	109.12	54.6	New perspectives in cell adhesion: RGD and integrins.	E Ruoslahti, M D Pierschbacher	Science	1987	2821619	No
920	3975	1987.5	105.19	52.6	Myeloid-derived suppressor cells as regulators of the immune system.	Dmitry I Gabrilovich, Srinivas Nagaraj	Nat Rev Immunol	2009	19197294	No
921	1987	1987.0	53.68	53.7	The molecular pathology of Alzheimer's disease.	D J Selkoe	Neuron	1991	1673054	No
922	3974	1987.0	0.0	0.0	Loss of recent memory after bilateral hippocampal lesions.	W B Scoville, B Milner	J Neurol Neurosurg Psychiatry	1957	13406589	Yes
923	1984	1984.0	48.38	48.4	The inflammatory reflex.	Kevin J Tracey	Nature	2002	12490958	No
924	1982	1982.0	52.84	52.8	The heme oxygenase system: a regulator of second messenger gases.	M D Maines	Annu Rev Pharmacol Toxicol	1997	9131263	No
925	1979	1979.0	62.62	62.6	Hybrid porous solids: past, present, future.	Gérard Férey	Chem Soc Rev	2008	18197340	Yes
926	1979	1979.0	62.2	62.2	Efficient methods to compute genomic predictions.	P M VanRaden	J Dairy Sci	2008	18946147	Yes
927	3957	1978.5	112.66	56.3	A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.	Y Matsumura, H Maeda	Cancer Res	1986	2946403	Yes
928	3948	1974.0	104.48	52.2	The heat-shock proteins.	S Lindquist, E A Craig	Annu Rev Genet	1988	2853609	No
929	3934	1967.0	116.82	58.4	Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging.	Michael D Fox, Marcus E Raichle	Nat Rev Neurosci	2007	17704812	No
930	1966	1966.0	43.41	43.4	The mitogen-activated protein kinase signal transduction pathway.	R J Davis	J Biol Chem	1993	8325833	No
931	1965	1965.0	65.51	65.5	Eye movements in reading and information processing: 20 years of research.	K Rayner	Psychol Bull	1998	9849112	No
932	3929	1964.5	0.0	0.0	Genetic regulatory mechanisms in the synthesis of proteins.	F Jacob, J Monod	J Mol Biol	1961	13718526	Yes
933	1964	1964.0	57.86	57.9	Protein oxidation and aging.	E R Stadtman	Science	1992	1355616	No
934	1963	1963.0	55.45	55.5	The importance of selenium to human health.	M P Rayman	Lancet	2000	10963212	No
935	1962	1962.0	53.72	53.7	Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis.	J Folkman	N Engl J Med	1995	7491141	No
936	3924	1962.0	0.0	0.0	Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol.	W R Morrison, L M Smith	J Lipid Res	1964	14221106	Yes
937	1962	1962.0	0.0	0.0	Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli.	G Bertani	J Bacteriol	1951	14888646	Yes
938	1961	1961.0	90.48	90.5	Central sensitization: implications for the diagnosis and treatment of pain.	Clifford J Woolf	Pain	2011	20961685	No
939	3920	1960.0	100.74	50.4	Nonparametric permutation tests for functional neuroimaging: a primer with examples.	Thomas E Nichols, Andrew P Holmes	Hum Brain Mapp	2002	11747097	Yes
940	1960	1960.0	39.58	39.6	Shelterin: the protein complex that shapes and safeguards human telomeres.	Titia de Lange	Genes Dev	2005	16166375	No
941	1959	1959.0	58.6	58.6	Pancreatic cancer.	Manuel Hidalgo	N Engl J Med	2010	20427809	No
942	5872	1957.3	121.79	40.6	Rapid and efficient site-specific mutagenesis without phenotypic selection.	T A Kunkel, J D Roberts, R A Zakour	Methods Enzymol	1987	3323813	Yes
943	1957	1957.0	0.0	0.0	Purinergic nerves.	G Burnstock	Pharmacol Rev	1972	4404211	No
944	1956	1956.0	61.57	61.6	Fetal origins of coronary heart disease.	D J Barker	BMJ	1995	7613432	No
945	1954	1954.0	0.0	0.0	The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera.	S V Boyden	J Exp Med	1951	14803635	Yes
946	1952	1952.0	39.37	39.4	NK cell recognition.	Lewis L Lanier	Annu Rev Immunol	2005	15771571	No
947	3902	1951.0	0.0	0.0	A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase.	R F Beers, I W Sizer	J Biol Chem	1952	14938361	Yes
948	1950	1950.0	52.84	52.8	Descending control of pain.	Mark J Millan	Prog Neurobiol	2002	12034378	No
949	1949	1949.0	66.8	66.8	Human error: models and management.	J Reason	BMJ	2000	10720363	Yes
950	1949	1949.0	48.14	48.1	Rab GTPases as coordinators of vesicle traffic.	Harald Stenmark	Nat Rev Mol Cell Biol	2009	19603039	No
951	1945	1945.0	69.92	69.9	Determination of glutathione and glutathione disulfide in biological samples.	M E Anderson	Methods Enzymol	1985	4088074	Yes
952	1944	1944.0	54.53	54.5	The biology of interleukin-6.	T Kishimoto	Blood	1989	2473791	No
953	1942	1942.0	0.0	0.0	Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle.	A Fleckenstein	Annu Rev Pharmacol Toxicol	1977	326161	No
954	1942	1942.0	0.0	0.0	Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate.	J P Chamberlain	Anal Biochem	1979	543547	Yes
955	3884	1942.0	96.09	48.0	Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.	G G Glenner, C W Wong	Biochem Biophys Res Commun	1984	6375662	Yes
956	1941	1941.0	40.52	40.5	Mechanisms of intracellular protein transport.	J E Rothman	Nature	1994	7969419	No
957	1941	1941.0	0.0	0.0	The oxidation of ribonuclease with performic acid.	C H Hirs	J Biol Chem	1956	13319283	Yes
958	1938	1938.0	52.99	53.0	Working memory: looking back and looking forward.	Alan Baddeley	Nat Rev Neurosci	2003	14523382	No
959	1937	1937.0	74.73	74.7	Epidemiology of viral hepatitis and hepatocellular carcinoma.	Hashem B El-Serag	Gastroenterology	2012	22537432	No
960	3872	1936.0	0.0	0.0	Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy.	I W McLean, P K Nakane	J Histochem Cytochem	1974	4374474	Yes
961	3871	1935.5	80.63	40.3	Mammalian MAP kinase signalling cascades.	L Chang, M Karin	Nature	2001	11242034	No
962	11605	1934.2	266.31	44.4	NMRPipe: a multidimensional spectral processing system based on UNIX pipes.	F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A Bax	J Biomol NMR	1995	8520220	Yes
963	1934	1934.0	46.81	46.8	Pathways towards and away from Alzheimer's disease.	Mark P Mattson	Nature	2004	15295589	No
964	1933	1933.0	56.37	56.4	Estimating causal effects from large data sets using propensity scores.	D B Rubin	Ann Intern Med	1997	9382394	No
965	3866	1933.0	119.03	59.5	The number of people with glaucoma worldwide in 2010 and 2020.	H A Quigley, A T Broman	Br J Ophthalmol	2006	16488940	Yes
966	3862	1931.0	126.24	63.1	A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.	Gary J Bennett, Y-K Xie	Pain	1988	2837713	Yes
967	5791	1930.3	116.64	38.9	Control of regulatory T cell development by the transcription factor Foxp3.	Shohei Hori, Takashi Nomura, Shimon Sakaguchi	Science	2003	12522256	Yes
968	1930	1930.0	57.84	57.8	Intracellular calcium homeostasis.	E Carafoli	Annu Rev Biochem	1987	3304139	No
969	1930	1930.0	60.36	60.4	A two process model of sleep regulation.	A A Borbély	Hum Neurobiol	1982	7185792	Yes
970	1930	1930.0	50.54	50.5	Inferring the historical patterns of biological evolution.	M Pagel	Nature	1999	10553904	Yes
971	1928	1928.0	63.95	64.0	Spinal and supraspinal factors in human muscle fatigue.	S C Gandevia	Physiol Rev	2001	11581501	No
972	1928	1928.0	49.63	49.6	Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences.	Edward V Loftus	Gastroenterology	2004	15168363	Yes
973	3856	1928.0	101.31	50.7	Hepatocellular carcinoma: epidemiology and molecular carcinogenesis.	Hashem B El-Serag, K Lenhard Rudolph	Gastroenterology	2007	17570226	No
974	3854	1927.0	0.0	0.0	Judgment under Uncertainty: Heuristics and Biases.	A Tversky, D Kahneman	Science	1974	17835457	Yes
975	1926	1926.0	50.43	50.4	Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens.	Jane Glazebrook	Annu Rev Phytopathol	2005	16078883	No
976	3851	1925.5	92.49	46.2	Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.	B A Reynolds, S Weiss	Science	1992	1553558	Yes
977	3851	1925.5	108.45	54.2	Insulin-like growth factors and their binding proteins: biological actions.	J I Jones, D R Clemmons	Endocr Rev	1995	7758431	No
978	3849	1924.5	106.87	53.4	Alzheimer's disease: the amyloid cascade hypothesis.	J A Hardy, G A Higgins	Science	1992	1566067	No
979	3849	1924.5	84.97	42.5	Lessons from hereditary colorectal cancer.	K W Kinzler, B Vogelstein	Cell	1996	8861899	No
980	1923	1923.0	35.47	35.5	ATM and related protein kinases: safeguarding genome integrity.	Yosef Shiloh	Nat Rev Cancer	2003	12612651	No
981	1923	1923.0	0.0	0.0	Crystalline Soybean Trypsin Inhibitor : Ii. General Properties.	M Kunitz	J Gen Physiol	1947	19873496	Yes
982	5768	1922.7	155.32	51.8	Cortical surface-based analysis. I. Segmentation and surface reconstruction.	A M Dale, B Fischl, M I Sereno	Neuroimage	1999	9931268	Yes
983	1922	1922.0	64.95	65.0	Plant products as antimicrobial agents.	M M Cowan	Clin Microbiol Rev	1999	10515903	No
984	1922	1922.0	41.47	41.5	Role of angiogenesis in tumor growth and metastasis.	Judah Folkman	Semin Oncol	2002	12516034	No
985	3840	1920.0	0.0	0.0	Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid.	A C Chang, S N Cohen	J Bacteriol	1978	149110	Yes
986	3839	1919.5	84.43	42.2	The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.	A J Ridley, A Hall	Cell	1992	1643657	Yes
987	1919	1919.0	35.52	35.5	In situ hybridization: an improved whole-mount method for Xenopus embryos.	R M Harland	Methods Cell Biol	1991	1811161	Yes
988	3838	1919.0	0.0	0.0	Acetylornithinase of Escherichia coli: partial purification and some properties.	H J Vogel, D M Bonner	J Biol Chem	1956	13278318	Yes
989	3838	1919.0	107.96	54.0	UniFrac: a new phylogenetic method for comparing microbial communities.	Catherine Lozupone, Rob Knight	Appl Environ Microbiol	2005	16332807	Yes
990	1918	1918.0	40.74	40.7	A cell culture model for T lymphocyte clonal anergy.	R H Schwartz	Science	1990	2113314	Yes
991	11508	1918.0	410.2	68.4	Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.	Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell Parkin	Int J Cancer	2010	21351269	Yes
992	1916	1916.0	39.52	39.5	CpG motifs in bacterial DNA and their immune effects.	Arthur M Krieg	Annu Rev Immunol	2002	11861616	No
993	3831	1915.5	179.24	89.6	Stages and processes of self-change of smoking: toward an integrative model of change.	J O Prochaska, C C DiClemente	J Consult Clin Psychol	1983	6863699	Yes
994	1913	1913.0	71.33	71.3	International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results.	C Herrmann	J Psychosom Res	1997	9055211	No
995	3824	1912.0	102.14	51.1	Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.	M Matsuda, R A DeFronzo	Diabetes Care	1999	10480510	Yes
996	1911	1911.0	81.49	81.5	The validity and practicality of sun-reactive skin types I through VI.	T B Fitzpatrick	Arch Dermatol	1988	3377516	Yes
997	1910	1910.0	47.17	47.2	DNA topoisomerases.	J C Wang	Annu Rev Biochem	1985	2992360	No
998	1909	1909.0	64.8	64.8	Intermediate filaments as mechanical integrators of cellular space.	E Lazarides	Nature	1980	7188712	Yes
999	1909	1909.0	0.0	0.0	Influences of glucose loading and of injected insulin on hepatic glucose output.	R Steele	Ann N Y Acad Sci	1959	13833973	Yes
1000	5720	1906.7	173.01	57.7	Immunity, inflammation, and cancer.	Sergei I Grivennikov, Florian R Greten, Michael Karin	Cell	2010	20303878	No
1001	1905	1905.0	65.82	65.8	The unfolded protein response: controlling cell fate decisions under ER stress and beyond.	Claudio Hetz	Nat Rev Mol Cell Biol	2012	22251901	No
1002	1904	1904.0	51.11	51.1	DNA topoisomerase poisons as antitumor drugs.	L F Liu	Annu Rev Biochem	1989	2549853	No
1003	5712	1904.0	224.46	74.8	Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA.	G Muyzer, E C de Waal, A G Uitterlinden	Appl Environ Microbiol	1993	7683183	Yes
1004	1903	1903.0	81.18	81.2	A rating scale for drug-induced akathisia.	T R Barnes	Br J Psychiatry	1989	2574607	Yes
1005	1902	1902.0	85.52	85.5	The Children's Depression, Inventory (CDI).	M Kovacs	Psychopharmacol Bull	1985	4089116	Yes
1006	1902	1902.0	57.31	57.3	Carbonic anhydrases: novel therapeutic applications for inhibitors and activators.	Claudiu T Supuran	Nat Rev Drug Discov	2008	18167490	No
1007	1901	1901.0	53.28	53.3	T cell exhaustion.	E John Wherry	Nat Immunol	2011	21739672	No
1008	3801	1900.5	103.31	51.7	Inositol phosphates and cell signalling.	M J Berridge, R F Irvine	Nature	1989	2550825	No
1009	1900	1900.0	0.0	0.0	Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system.	D M Neville	J Biol Chem	1971	5127429	Yes
1010	7600	1900.0	174.5	43.6	Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.	A Krogh, B Larsson, G von Heijne, E L Sonnhammer	J Mol Biol	2001	11152613	Yes
1011	1898	1898.0	0.0	0.0	On estimating the relation between blood group and disease.	B Woolf	Ann Hum Genet	1955	14388528	Yes
1012	5693	1897.7	193.17	64.4	Parallel organization of functionally segregated circuits linking basal ganglia and cortex.	G E Alexander, M R DeLong, P L Strick	Annu Rev Neurosci	1986	3085570	No
1013	1897	1897.0	0.0	0.0	Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma.	A Breslow	Ann Surg	1970	5477666	Yes
1014	1897	1897.0	0.0	0.0	Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?	J V Neel	Am J Hum Genet	1962	13937884	Yes
1015	1896	1896.0	82.7	82.7	Missing data analysis: making it work in the real world.	John W Graham	Annu Rev Psychol	2009	18652544	No
1016	3791	1895.5	0.0	0.0	Variations in pattern of pubertal changes in girls.	W A Marshall, J M Tanner	Arch Dis Child	1969	5785179	Yes
1017	1895	1895.0	0.0	0.0	In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain.	T R Chen	Exp Cell Res	1977	65285	Yes
1018	1895	1895.0	84.33	84.3	Brain dopamine receptors.	P Seeman	Pharmacol Rev	1980	6117090	No
1019	5684	1894.7	1753.55	584.5	Cancer statistics, 2020.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2020	31912902	Yes
1020	1893	1893.0	66.16	66.2	Simplified calculation of body-surface area.	R D Mosteller	N Engl J Med	1987	3657876	Yes
1021	3786	1893.0	96.18	48.1	Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.	P J Barnes, M Karin	N Engl J Med	1997	9091804	No
1022	3781	1890.5	78.58	39.3	Network biology: understanding the cell's functional organization.	Albert-László Barabási, Zoltán N Oltvai	Nat Rev Genet	2004	14735121	No
1023	1890	1890.0	65.31	65.3	Qualitative research: standards, challenges, and guidelines.	K Malterud	Lancet	2001	11513933	Yes
1024	1890	1890.0	0.0	0.0	Analysis of tissue and arterial blood temperatures in the resting human forearm.	H H Pennes	J Appl Physiol	1948	18887578	Yes
1025	1890	1890.0	57.11	57.1	The nuclear factor NF-kappaB pathway in inflammation.	Toby Lawrence	Cold Spring Harb Perspect Biol	2009	20457564	No
1026	1889	1889.0	42.97	43.0	Signal sequences. The limits of variation.	G von Heijne	J Mol Biol	1985	4032478	Yes
1027	3774	1887.0	90.28	45.1	Base-calling of automated sequencer traces using phred. II. Error probabilities.	B Ewing, P Green	Genome Res	1998	9521922	Yes
1028	1885	1885.0	0.0	0.0	Complete nucleotide sequence of the Escherichia coli plasmid pBR322.	J G Sutcliffe	Cold Spring Harb Symp Quant Biol	1979	383387	Yes
1029	1885	1885.0	57.02	57.0	Calbindin D-28k and parvalbumin in the rat nervous system.	M R Celio	Neuroscience	1990	2199841	Yes
1030	1885	1885.0	39.31	39.3	Mechanisms of type-I- and type-II-interferon-mediated signalling.	Leonidas C Platanias	Nat Rev Immunol	2005	15864272	No
1031	1883	1883.0	0.0	0.0	A modified card sorting test sensitive to frontal lobe defects.	H E Nelson	Cortex	1976	1009768	Yes
1032	1883	1883.0	54.95	55.0	Excitotoxic cell death.	D W Choi	J Neurobiol	1992	1361523	No
1033	5648	1882.7	0.0	0.0	Research diagnostic criteria: rationale and reliability.	R L Spitzer, J Endicott, E Robins	Arch Gen Psychiatry	1978	655775	Yes
1034	3764	1882.0	93.4	46.7	Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.	M Nei, T Gojobori	Mol Biol Evol	1986	3444411	Yes
1035	1881	1881.0	40.23	40.2	Molecular bases for circadian clocks.	J C Dunlap	Cell	1999	9988221	No
1036	3760	1880.0	0.0	0.0	An efficient mRNA-dependent translation system from reticulocyte lysates.	H R Pelham, R J Jackson	Eur J Biochem	1976	823012	Yes
1037	3757	1878.5	108.92	54.5	Application of phylogenetic networks in evolutionary studies.	Daniel H Huson, David Bryant	Mol Biol Evol	2006	16221896	Yes
1038	1877	1877.0	42.15	42.1	Biology of natural killer cells.	G Trinchieri	Adv Immunol	1989	2683611	No
1039	1877	1877.0	34.9	34.9	Signaling--2000 and beyond.	T Hunter	Cell	2000	10647936	No
1040	1873	1873.0	53.17	53.2	The episodic buffer: a new component of working memory?	Baddeley	Trends Cogn Sci	2000	11058819	Yes
1041	1872	1872.0	39.99	40.0	Metastasis to bone: causes, consequences and therapeutic opportunities.	Gregory R Mundy	Nat Rev Cancer	2002	12154351	No
1042	5611	1870.3	141.71	47.2	GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants.	R A Jefferson, T A Kavanagh, M W Bevan	EMBO J	1987	3327686	Yes
1043	7479	1869.8	188.16	47.0	p53 mutations in human cancers.	M Hollstein, D Sidransky, B Vogelstein, C C Harris	Science	1991	1905840	No
1044	1867	1867.0	74.89	74.9	Approximate entropy as a measure of system complexity.	S M Pincus	Proc Natl Acad Sci U S A	1991	11607165	Yes
1045	1867	1867.0	53.85	53.9	The blood-brain barrier in health and chronic neurodegenerative disorders.	Berislav V Zlokovic	Neuron	2008	18215617	No
1046	1866	1866.0	43.3	43.3	Defensins: antimicrobial peptides of innate immunity.	Tomas Ganz	Nat Rev Immunol	2003	12949495	No
1047	3731	1865.5	87.15	43.6	The Fas death factor.	S Nagata, P Golstein	Science	1995	7533326	No
1048	3728	1864.0	96.59	48.3	Leptin and the regulation of body weight in mammals.	J M Friedman, J L Halaas	Nature	1998	9796811	No
1049	1864	1864.0	55.06	55.1	Japanese Classification of Gastric Carcinoma - 2nd English Edition -	Japanese Gastric Cancer Association	Gastric Cancer	1998	11957040	Yes
1050	1863	1863.0	48.74	48.7	Flow-mediated endothelial mechanotransduction.	P F Davies	Physiol Rev	1995	7624393	No
1051	3714	1857.0	0.0	0.0	Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells.	J G Rheinwald, H Green	Cell	1975	1052771	Yes
1052	3714	1857.0	81.18	40.6	Raster3D: photorealistic molecular graphics.	E A Merritt, D J Bacon	Methods Enzymol	1997	18488322	Yes
1053	3710	1855.0	122.37	61.2	Oxygen toxicity, oxygen radicals, transition metals and disease.	B Halliwell, J M Gutteridge	Biochem J	1984	6326753	No
1054	1853	1853.0	0.0	0.0	Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal.	S Cohen	J Biol Chem	1962	13880319	Yes
1055	1851	1851.0	39.19	39.2	The expanding role of mitochondria in apoptosis.	X Wang	Genes Dev	2001	11711427	No
1056	1850	1850.0	62.69	62.7	The use of a plus-maze to measure anxiety in the mouse.	R G Lister	Psychopharmacology (Berl)	1987	3110839	Yes
1057	3698	1849.0	76.91	38.5	Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals.	Rudolf Jaenisch, Adrian Bird	Nat Genet	2003	12610534	No
1058	1847	1847.0	51.66	51.7	Epidemiology of insomnia: what we know and what we still need to learn.	Maurice M Ohayon	Sleep Med Rev	2002	12531146	Yes
1059	1844	1844.0	43.49	43.5	A clearer vision for in vivo imaging.	R Weissleder	Nat Biotechnol	2001	11283581	No
1060	3688	1844.0	0.0	0.0	Immunoassay of insulin with insulin-antibody precipitate.	C N Hales, P J Randle	Biochem J	1963	13952078	Yes
1061	5531	1843.7	0.0	0.0	A rapid method for the isolation of functional thymus-derived murine lymphocytes.	M H Julius, E Simpson, L A Herzenberg	Eur J Immunol	1973	4587740	Yes
1062	1843	1843.0	45.39	45.4	Thioredoxin.	A Holmgren	Annu Rev Biochem	1985	3896121	No
1063	3685	1842.5	107.71	53.9	Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration.	B J Marshall, J R Warren	Lancet	1984	6145023	Yes
1064	3683	1841.5	84.78	42.4	Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.	T Miyashita, J C Reed	Cell	1995	7834749	Yes
1065	3683	1841.5	152.91	76.5	Extracellular vesicles: exosomes, microvesicles, and friends.	Graça Raposo, Willem Stoorvogel	J Cell Biol	2013	23420871	No
1066	3680	1840.0	76.37	38.2	The Wnt signaling pathway in development and disease.	Catriona Y Logan, Roel Nusse	Annu Rev Cell Dev Biol	2004	15473860	No
1067	7353	1838.2	193.28	48.3	Matrix elasticity directs stem cell lineage specification.	Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E Discher	Cell	2006	16923388	Yes
1068	1836	1836.0	33.7	33.7	The regulation of E2F by pRB-family proteins.	N Dyson	Genes Dev	1998	9694791	No
1069	1836	1836.0	45.29	45.3	Animal mitochondrial genomes.	J L Boore	Nucleic Acids Res	1999	10101183	No
1070	3667	1833.5	76.15	38.1	Smad-dependent and Smad-independent pathways in TGF-beta family signalling.	Rik Derynck, Ying E Zhang	Nature	2003	14534577	No
1071	3663	1831.5	88.12	44.1	Brown adipose tissue: function and physiological significance.	Barbara Cannon, Jan Nedergaard	Physiol Rev	2004	14715917	No
1072	3662	1831.0	94.19	47.1	Cutaneous wound healing.	A J Singer, R A Clark	N Engl J Med	1999	10471461	No
1073	3661	1830.5	88.43	44.2	The acute respiratory distress syndrome.	L B Ware, M A Matthay	N Engl J Med	2000	10793167	No
1074	1830	1830.0	0.0	0.0	A rating instrument for anxiety disorders.	W W Zung	Psychosomatics	1971	5172928	Yes
1075	3659	1829.5	89.99	45.0	The future of genetic studies of complex human diseases.	N Risch, K Merikangas	Science	1996	8801636	Yes
1076	7314	1828.5	256.39	64.1	Reporting results of cancer treatment.	A B Miller, B Hoogstraten, M Staquet, A Winkler	Cancer	1981	7459811	Yes
1077	1828	1828.0	0.0	0.0	The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides.	G S Manning	Q Rev Biophys	1978	353876	No
1078	1828	1828.0	37.84	37.8	Signalling pathways of the TNF superfamily: a double-edged sword.	Bharat B Aggarwal	Nat Rev Immunol	2003	12949498	No
1079	3656	1828.0	121.4	60.7	Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections.	Jeng-Da Chai, Martin Head-Gordon	Phys Chem Chem Phys	2008	18989472	Yes
1080	1824	1824.0	0.0	0.0	A simple fluorometric assay for lipoperoxide in blood plasma.	K Yagi	Biochem Med	1976	962904	Yes
1081	7295	1823.8	0.0	0.0	Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.	D J Sahn, A DeMaria, J Kisslo, A Weyman	Circulation	1978	709763	Yes
1082	1823	1823.0	68.27	68.3	Physiological aspects of primary hypertension.	B Folkow	Physiol Rev	1982	6461865	No
1083	1822	1822.0	46.72	46.7	Determination and analysis of urea and guanidine hydrochloride denaturation curves.	C N Pace	Methods Enzymol	1986	3773761	Yes
1084	1818	1818.0	49.15	49.1	Hepatitis B virus infection.	W M Lee	N Engl J Med	1997	9392700	No
1085	3636	1818.0	72.18	36.1	Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.	M Karin, Y Ben-Neriah	Annu Rev Immunol	2000	10837071	No
1086	16359	1817.7	1038.97	115.4	Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.	Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray	Int J Cancer	2015	25220842	Yes
1087	1816	1816.0	49.95	50.0	Mechanisms of hepatic fibrogenesis.	Scott L Friedman	Gastroenterology	2008	18471545	No
1088	16343	1815.9	366.49	40.7	Cytoscape: a software environment for integrated models of biomolecular interaction networks.	Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey Ideker	Genome Res	2003	14597658	Yes
1089	1815	1815.0	53.64	53.6	The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation.	G P Chrousos	N Engl J Med	1995	7715646	No
1090	1815	1815.0	53.17	53.2	Accurate Coulomb-fitting basis sets for H to Rn.	Florian Weigend	Phys Chem Chem Phys	2006	16633586	Yes
1091	3629	1814.5	0.0	0.0	Polymyositis and dermatomyositis (first of two parts).	A Bohan, J B Peter	N Engl J Med	1975	1090839	No
1092	14515	1814.4	413.23	51.7	Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.	R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A Erlich	Science	1988	2448875	Yes
1093	1814	1814.0	46.12	46.1	Cancer chemoprevention with dietary phytochemicals.	Young-Joon Surh	Nat Rev Cancer	2003	14570043	No
1094	1813	1813.0	0.0	0.0	A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field.	D A Robinson	IEEE Trans Biomed Eng	1963	14121113	Yes
1095	1812	1812.0	62.32	62.3	Keratoconus.	Y S Rabinowitz	Surv Ophthalmol	1998	9493273	No
1096	1810	1810.0	40.87	40.9	Theta oscillations in the hippocampus.	György Buzsáki	Neuron	2002	11832222	No
1097	1810	1810.0	56.5	56.5	Hazards of heavy metal contamination.	Lars Järup	Br Med Bull	2003	14757716	No
1098	3617	1808.5	139.69	69.8	The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories.	P F Lovibond, S H Lovibond	Behav Res Ther	1995	7726811	Yes
1099	1807	1807.0	60.05	60.0	Social cognitive theory: an agentic perspective.	A Bandura	Annu Rev Psychol	2001	11148297	Yes
1100	5418	1806.0	176.83	58.9	Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders.	C Lord, M Rutter, A Le Couteur	J Autism Dev Disord	1994	7814313	Yes
1101	1804	1804.0	39.11	39.1	Thrombin signalling and protease-activated receptors.	S R Coughlin	Nature	2000	11001069	No
1102	1804	1804.0	34.77	34.8	Automated electron microscope tomography using robust prediction of specimen movements.	David N Mastronarde	J Struct Biol	2005	16182563	Yes
1103	3604	1802.0	167.41	83.7	The Health Belief Model: a decade later.	N K Janz, M H Becker	Health Educ Q	1984	6392204	No
1104	1802	1802.0	36.95	37.0	Systems biology: a brief overview.	Hiroaki Kitano	Science	2002	11872829	No
1105	3604	1802.0	94.41	47.2	The endophenotype concept in psychiatry: etymology and strategic intentions.	Irving I Gottesman, Todd D Gould	Am J Psychiatry	2003	12668349	No
1106	1801	1801.0	48.33	48.3	Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details.	R D Pascual-Marqui	Methods Find Exp Clin Pharmacol	2002	12575463	No
1107	1801	1801.0	46.76	46.8	Dopamine, learning and motivation.	Roy A Wise	Nat Rev Neurosci	2004	15152198	No
1108	5403	1801.0	148.81	49.6	Canonical sampling through velocity rescaling.	Giovanni Bussi, Davide Donadio, Michele Parrinello	J Chem Phys	2007	17212484	Yes
1109	1796	1796.0	40.08	40.1	The immunopathogenesis of sepsis.	Jonathan Cohen	Nature	2002	12490963	No
1110	1796	1796.0	0.0	0.0	The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application.	S Hestrin	J Biol Chem	1949	18133390	Yes
1111	5383	1794.3	136.68	45.6	Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.	Z N Oltvai, C L Milliman, S J Korsmeyer	Cell	1993	8358790	Yes
1112	1793	1793.0	49.7	49.7	A computational procedure for determining energetically favorable binding sites on biologically important macromolecules.	P J Goodford	J Med Chem	1985	3892003	Yes
1113	3585	1792.5	163.36	81.7	The Brief Symptom Inventory: an introductory report.	L R Derogatis, N Melisaratos	Psychol Med	1983	6622612	Yes
1114	1792	1792.0	59.42	59.4	Heavy metal intensification of DAB-based HRP reaction product.	J C Adams	J Histochem Cytochem	1981	7252134	Yes
1115	1791	1791.0	0.0	0.0	A classification of hand preference by association analysis.	M Annett	Br J Psychol	1970	5457503	Yes
1116	5373	1791.0	114.84	38.3	EMBOSS: the European Molecular Biology Open Software Suite.	P Rice, I Longden, A Bleasby	Trends Genet	2000	10827456	Yes
1117	3581	1790.5	93.53	46.8	Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.	Michael T Lin, M Flint Beal	Nature	2006	17051205	No
1118	1790	1790.0	41.03	41.0	Cellular mechanisms of insulin resistance.	G I Shulman	J Clin Invest	2000	10903330	No
1119	1790	1790.0	36.95	37.0	Antiviral actions of interferons.	C E Samuel	Clin Microbiol Rev	2001	11585785	No
1120	5367	1789.0	125.82	41.9	A new statistical method for haplotype reconstruction from population data.	M Stephens, N J Smith, P Donnelly	Am J Hum Genet	2001	11254454	Yes
1121	1789	1789.0	0.0	0.0	The measurement of volume changes in human limbs.	R J Whitney	J Physiol	1953	13085295	Yes
1122	1788	1788.0	60.6	60.6	Physiological actions of taurine.	R J Huxtable	Physiol Rev	1992	1731369	No
1123	1786	1786.0	37.01	37.0	DNA topoisomerases: structure, function, and mechanism.	J J Champoux	Annu Rev Biochem	2001	11395412	No
1124	1786	1786.0	50.77	50.8	The physiology of glucagon-like peptide 1.	Jens Juul Holst	Physiol Rev	2007	17928588	No
1125	5356	1785.3	178.76	59.6	AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet.	P G Reeves, F H Nielsen, G C Fahey	J Nutr	1993	8229312	No
1126	1785	1785.0	0.0	0.0	High-speed scanning in human memory.	S Sternberg	Science	1966	5939936	Yes
1127	7137	1784.2	0.0	0.0	Antibiotic susceptibility testing by a standardized single disk method.	A W Bauer, W M Kirby, J C Sherris, M Turck	Am J Clin Pathol	1966	5325707	Yes
1128	1784	1784.0	41.32	41.3	DNA topoisomerases.	J C Wang	Annu Rev Biochem	1996	8811192	No
1129	7134	1783.5	241.6	60.4	Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.	A J Hughes, S E Daniel, L Kilford, A J Lees	J Neurol Neurosurg Psychiatry	1992	1564476	Yes
1130	1783	1783.0	43.81	43.8	The mitochondrial permeability transition pore and its role in cell death.	M Crompton	Biochem J	1999	10393078	No
1131	1783	1783.0	39.78	39.8	TRP channels as cellular sensors.	David E Clapham	Nature	2003	14654832	No
1132	1783	1783.0	62.62	62.6	The free-energy principle: a unified brain theory?	Karl Friston	Nat Rev Neurosci	2010	20068583	No
1133	5348	1782.7	155.7	51.9	Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors.	F E Harrell, K L Lee, D B Mark	Stat Med	1996	8668867	No
1134	1781	1781.0	0.0	0.0	Estimability and estimation in case-referent studies.	O Miettinen	Am J Epidemiol	1976	1251836	Yes
1135	1781	1781.0	42.15	42.1	Global cancer statistics in the year 2000.	D M Parkin	Lancet Oncol	2001	11905707	No
1136	1781	1781.0	46.29	46.3	The hydrogen bond in the solid state.	Thomas Steiner	Angew Chem Int Ed Engl	2002	12491444	Yes
1137	3560	1780.0	119.68	59.8	Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease.	R A DeFronzo, E Ferrannini	Diabetes Care	1991	2044434	No
1138	1780	1780.0	48.58	48.6	Accurate description of van der Waals complexes by density functional theory including empirical corrections.	Stefan Grimme	J Comput Chem	2004	15224390	Yes
1139	5340	1780.0	174.82	58.3	The brain's default network: anatomy, function, and relevance to disease.	Randy L Buckner, Jessica R Andrews-Hanna, Daniel L Schacter	Ann N Y Acad Sci	2008	18400922	No
1140	1779	1779.0	0.0	0.0	A theory of cerebellar cortex.	D Marr	J Physiol	1969	5784296	Yes
1141	3557	1778.5	0.0	0.0	Mathematical model for studying genetic variation in terms of restriction endonucleases.	M Nei, W H Li	Proc Natl Acad Sci U S A	1979	291943	Yes
1142	1778	1778.0	88.19	88.2	Performance-oriented assessment of mobility problems in elderly patients.	M E Tinetti	J Am Geriatr Soc	1986	3944402	Yes
1143	1776	1776.0	66.05	66.0	Why patients use alternative medicine: results of a national study.	J A Astin	JAMA	1998	9605899	Yes
1144	3549	1774.5	0.0	0.0	Maturation of the head of bacteriophage T4. I. DNA packaging events.	U K Laemmli, M Favre	J Mol Biol	1973	4204102	Yes
1145	1774	1774.0	59.55	59.5	Sick individuals and sick populations.	G Rose	Int J Epidemiol	1985	3872850	Yes
1146	1771	1771.0	67.15	67.2	Recognition-by-components: a theory of human image understanding.	Irving Biederman	Psychol Rev	1987	3575582	Yes
1147	1771	1771.0	0.0	0.0	The influence of some cations on an adenosine triphosphatase from peripheral nerves.	J C Skou	Biochim Biophys Acta	1957	13412736	Yes
1148	1771	1771.0	38.85	38.9	The complex language of chromatin regulation during transcription.	Shelley L Berger	Nature	2007	17522673	No
1149	3541	1770.5	74.66	37.3	Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia.	C D Nobes, A Hall	Cell	1995	7536630	Yes
1150	3541	1770.5	124.58	62.3	Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine.	M H Zweig, G Campbell	Clin Chem	1993	8472349	No
1151	3537	1768.5	0.0	0.0	Multiple receptors for dopamine.	J W Kebabian, D B Calne	Nature	1979	215920	No
1152	1768	1768.0	0.0	0.0	Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.	U Ungerstedt	Acta Physiol Scand Suppl	1971	4332693	Yes
1153	7069	1767.2	281.29	70.3	A simple technique for quantitation of low levels of DNA damage in individual cells.	N P Singh, M T McCoy, R R Tice, E L Schneider	Exp Cell Res	1988	3345800	Yes
1154	1767	1767.0	36.81	36.8	Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls.	R J Kaufman	Genes Dev	1999	10346810	No
1155	1767	1767.0	45.57	45.6	DAMPs, PAMPs and alarmins: all we need to know about danger.	Marco E Bianchi	J Leukoc Biol	2007	17032697	No
1156	1765	1765.0	51.77	51.8	Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.	A Dunaif	Endocr Rev	1997	9408743	No
1157	1765	1765.0	32.94	32.9	Mechanisms of alternative pre-messenger RNA splicing.	Douglas L Black	Annu Rev Biochem	2003	12626338	No
1158	7056	1764.0	175.83	44.0	Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels.	A Shevchenko, M Wilm, O Vorm, M Mann	Anal Chem	1996	8779443	Yes
1159	1763	1763.0	44.93	44.9	The global health burden of infection-associated cancers in the year 2002.	Donald Maxwell Parkin	Int J Cancer	2006	16404738	Yes
1160	7045	1761.2	271.88	68.0	The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire.	T F Heatherton, L T Kozlowski, R C Frecker, K O Fagerström	Br J Addict	1991	1932883	Yes
1161	1761	1761.0	44.72	44.7	The dawning era of polymer therapeutics.	Ruth Duncan	Nat Rev Drug Discov	2003	12750738	No
1162	3521	1760.5	122.09	61.0	Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.	G Di Chiara, A Imperato	Proc Natl Acad Sci U S A	1988	2899326	Yes
1163	1760	1760.0	45.74	45.7	Negative refraction makes a perfect lens	Pendry	Phys Rev Lett	2000	11041972	Yes
1164	1760	1760.0	58.63	58.6	TGFβ signalling in context.	Joan Massagué	Nat Rev Mol Cell Biol	2012	22992590	No
1165	5275	1758.3	104.4	34.8	Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.	Jason D Fontenot, Marc A Gavin, Alexander Y Rudensky	Nat Immunol	2003	12612578	Yes
1166	3514	1757.0	85.76	42.9	Protein folding in the cell.	M J Gething, J Sambrook	Nature	1992	1731198	No
1167	1757	1757.0	0.0	0.0	On respiratory impairment in cancer cells.	O Warburg	Science	1956	13351639	Yes
1168	1754	1754.0	45.5	45.5	Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials.	Fiona Turnbull	Lancet	2003	14615107	Yes
1169	1753	1753.0	62.03	62.0	The role of hormone receptors and GTP-regulatory proteins in membrane transduction.	M Rodbell	Nature	1980	6101906	Yes
1170	1753	1753.0	37.01	37.0	An extensively modified version of MolScript that includes greatly enhanced coloring capabilities.	R M Esnouf	J Mol Graph Model	1997	9385560	Yes
1171	1753	1753.0	39.81	39.8	A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics.	J SantaLucia	Proc Natl Acad Sci U S A	1998	9465037	Yes
1172	5257	1752.3	258.83	86.3	HISAT: a fast spliced aligner with low memory requirements.	Daehwan Kim, Ben Langmead, Steven L Salzberg	Nat Methods	2015	25751142	Yes
1173	1752	1752.0	47.8	47.8	G proteins and dual control of adenylate cyclase.	A G Gilman	Cell	1984	6321035	Yes
1174	1752	1752.0	47.2	47.2	A theory of cortical responses.	Karl Friston	Philos Trans R Soc Lond B Biol Sci	2005	15937014	No
1175	3501	1750.5	93.07	46.5	Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.	K D McCarthy, J de Vellis	J Cell Biol	1980	6248568	Yes
1176	1749	1749.0	46.02	46.0	Interfaces and the driving force of hydrophobic assembly.	David Chandler	Nature	2005	16193038	No
1177	5242	1747.3	209.58	69.9	featureCounts: an efficient general purpose program for assigning sequence reads to genomic features.	Yang Liao, Gordon K Smyth, Wei Shi	Bioinformatics	2014	24227677	Yes
1178	1747	1747.0	51.15	51.1	Endoplasmic reticulum stress and the inflammatory basis of metabolic disease.	Gökhan S Hotamisligil	Cell	2010	20303879	No
1179	1744	1744.0	58.34	58.3	Health consequences of intimate partner violence.	Jacquelyn C Campbell	Lancet	2002	11965295	No
1180	1743	1743.0	60.12	60.1	Guided Search 2.0 A revised model of visual search.	J M Wolfe	Psychon Bull Rev	1994	24203471	Yes
1181	5226	1742.0	131.46	43.8	APE: Analyses of Phylogenetics and Evolution in R language.	Emmanuel Paradis, Julien Claude, Korbinian Strimmer	Bioinformatics	2004	14734327	Yes
1182	3482	1741.0	0.0	0.0	A complementation analysis of the restriction and modification of DNA in Escherichia coli.	H W Boyer, D Roulland-Dussoix	J Mol Biol	1969	4896022	Yes
1183	1741	1741.0	45.05	45.0	Drug-like properties and the causes of poor solubility and poor permeability.	C A Lipinski	J Pharmacol Toxicol Methods	2000	11274893	No
1184	1741	1741.0	0.0	0.0	A personality scale of manifest anxiety.	J A Taylor	J Abnorm Psychol	1953	13052352	Yes
1185	1740	1740.0	58.85	58.9	Drugs of abuse: anatomy, pharmacology and function of reward pathways.	G F Koob	Trends Pharmacol Sci	1992	1604710	No
1186	3477	1738.5	160.87	80.4	Multiwfn: a multifunctional wavefunction analyzer.	Tian Lu, Feiwu Chen	J Comput Chem	2012	22162017	Yes
1187	1738	1738.0	0.0	0.0	The etiology of chondromalacia patellae.	R E Outerbridge	J Bone Joint Surg Br	1961	14038135	Yes
1188	1737	1737.0	42.8	42.8	Metabolomics--the link between genotypes and phenotypes.	Oliver Fiehn	Plant Mol Biol	2002	11860207	No
1189	1736	1736.0	81.63	81.6	Determinants of low birth weight: methodological assessment and meta-analysis.	M S Kramer	Bull World Health Organ	1987	3322602	No
1190	1736	1736.0	48.79	48.8	New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures.	R Y Tsien	Biochemistry	1980	6770893	Yes
1191	1736	1736.0	42.34	42.3	Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome.	B L Wajchenberg	Endocr Rev	2000	11133069	No
1192	19095	1735.9	422.32	38.4	Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.	Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P Mesirov	Proc Natl Acad Sci U S A	2005	16199517	Yes
1193	1735	1735.0	40.04	40.0	Steroid receptor regulated transcription of specific genes and gene networks.	K R Yamamoto	Annu Rev Genet	1985	3909942	No
1194	3469	1734.5	66.67	33.3	Rho GTPases in cell biology.	Sandrine Etienne-Manneville, Alan Hall	Nature	2002	12478284	No
1195	1733	1733.0	0.0	0.0	Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu.	M J Casadaban	J Mol Biol	1976	781293	Yes
1196	1733	1733.0	62.1	62.1	A cortical network for directed attention and unilateral neglect.	M M Mesulam	Ann Neurol	1981	7032417	No
1197	1730	1730.0	0.0	0.0	Comparison of the predicted and observed secondary structure of T4 phage lysozyme.	B W Matthews	Biochim Biophys Acta	1975	1180967	Yes
1198	1730	1730.0	44.82	44.8	The pathophysiology of tumor necrosis factors.	P Vassalli	Annu Rev Immunol	1992	1590993	No
1199	1729	1729.0	46.3	46.3	Interleukin-6: an overview.	J Van Snick	Annu Rev Immunol	1990	2188664	No
1200	5184	1728.0	172.39	57.5	Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data.	L Excoffier, P E Smouse, J M Quattro	Genetics	1992	1644282	Yes
1201	1727	1727.0	56.53	56.5	Calculation of substrate oxidation rates in vivo from gaseous exchange.	K N Frayn	J Appl Physiol Respir Environ Exerc Physiol	1983	6618956	Yes
1202	1726	1726.0	54.93	54.9	An overview of brominated flame retardants in the environment.	Cynthia A de Wit	Chemosphere	2002	11999784	No
1203	5169	1723.0	113.34	37.8	Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons.	A Nicholls, K A Sharp, B Honig	Proteins	1991	1758883	Yes
1204	1723	1723.0	39.15	39.1	The synaptic vesicle cycle: a cascade of protein-protein interactions.	T C Südhof	Nature	1995	7791897	No
1205	1722	1722.0	93.87	93.9	The assessment of clinical skills/competence/performance.	G E Miller	Acad Med	1990	2400509	Yes
1206	1721	1721.0	62.48	62.5	Cyclosporine.	B D Kahan	N Engl J Med	1989	2687689	No
1207	1721	1721.0	67.96	68.0	Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review.	H U Wittchen	J Psychiatr Res	1994	8064641	No
1208	1721	1721.0	48.53	48.5	The extracellular matrix: not just pretty fibrils.	Richard O Hynes	Science	2009	19965464	No
1209	3440	1720.0	93.41	46.7	Prediction of protein antigenic determinants from amino acid sequences.	T P Hopp, K R Woods	Proc Natl Acad Sci U S A	1981	6167991	Yes
1210	3440	1720.0	87.62	43.8	Measuring the thickness of the human cerebral cortex from magnetic resonance images.	B Fischl, A M Dale	Proc Natl Acad Sci U S A	2000	10984517	Yes
1211	1720	1720.0	38.24	38.2	Developmental regulation of the growth plate.	Henry M Kronenberg	Nature	2003	12748651	No
1212	5159	1719.7	170.45	56.8	Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire.	R L Spitzer, K Kroenke, J B Williams	JAMA	1999	10568646	Yes
1213	3439	1719.5	76.34	38.2	Cell death: critical control points.	Nika N Danial, Stanley J Korsmeyer	Cell	2004	14744432	No
1214	1719	1719.0	101.52	101.5	Determination and quantification of content validity.	M R Lynn	Nurs Res	1986	3640358	Yes
1215	1719	1719.0	0.0	0.0	Positional information and the spatial pattern of cellular differentiation.	L Wolpert	J Theor Biol	1969	4390734	Yes
1216	3438	1719.0	88.64	44.3	The biology of vascular endothelial growth factor.	N Ferrara, T Davis-Smyth	Endocr Rev	1997	9034784	No
1217	1719	1719.0	72.61	72.6	The Resonating Valence Bond State in La2CuO4 and Superconductivity.	P W Anderson	Science	1987	17818979	Yes
1218	1719	1719.0	43.44	43.4	Targeting PI3K signalling in cancer: opportunities, challenges and limitations.	Jeffrey A Engelman	Nat Rev Cancer	2009	19629070	No
1219	1717	1717.0	0.0	0.0	ATPase activity of myosin correlated with speed of muscle shortening.	M Bárány	J Gen Physiol	1967	4227924	Yes
1220	1717	1717.0	32.7	32.7	CD4+ CD25+ suppressor T cells: more questions than answers.	Ethan M Shevach	Nat Rev Immunol	2002	12093005	No
1221	1717	1717.0	35.01	35.0	Notch signalling: a simple pathway becomes complex.	Sarah J Bray	Nat Rev Mol Cell Biol	2006	16921404	No
1222	5149	1716.3	135.64	45.2	Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.	G S Hotamisligil, N S Shargill, B M Spiegelman	Science	1993	7678183	Yes
1223	1716	1716.0	0.0	0.0	Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals.	J N Dumont	J Morphol	1972	4109871	Yes
1224	6862	1715.5	148.17	37.0	WebLogo: a sequence logo generator.	Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E Brenner	Genome Res	2004	15173120	Yes
1225	5143	1714.3	232.17	77.4	Some statistical methods useful in circulation research.	S Wallenstein, C L Zucker, J L Fleiss	Circ Res	1980	7379260	Yes
1226	1714	1714.0	40.38	40.4	Neutrophils and immunity: challenges and opportunities.	Carl Nathan	Nat Rev Immunol	2006	16498448	No
1227	1712	1712.0	33.81	33.8	Approaching the asymptote? Evolution and revolution in immunology.	C A Janeway	Cold Spring Harb Symp Quant Biol	1989	2700931	No
1228	1711	1711.0	0.0	0.0	The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers.	R Ross	J Cell Biol	1971	4327464	Yes
1229	11976	1710.9	277.54	39.6	Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes.	Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman	Genome Biol	2002	12184808	Yes
1230	1710	1710.0	0.0	0.0	Dynamic properties of mammalian skeletal muscles.	R I Close	Physiol Rev	1972	4256989	No
1231	6834	1708.5	133.47	33.4	Transformation of intact yeast cells treated with alkali cations.	H Ito, Y Fukuda, K Murata, A Kimura	J Bacteriol	1983	6336730	Yes
1232	1708	1708.0	0.0	0.0	The statistical analysis of enzyme kinetic data.	W W Cleland	Adv Enzymol Relat Areas Mol Biol	1967	4881884	No
1233	1708	1708.0	46.3	46.3	Follicular helper CD4 T cells (TFH).	Shane Crotty	Annu Rev Immunol	2011	21314428	No
1234	3415	1707.5	0.0	0.0	The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent.	A E Bolton, W M Hunter	Biochem J	1973	4733239	Yes
1235	6825	1706.2	243.69	60.9	A brief measure for assessing generalized anxiety disorder: the GAD-7.	Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd Löwe	Arch Intern Med	2006	16717171	Yes
1236	1706	1706.0	36.47	36.5	Structure and regulation of voltage-gated Ca2+ channels.	W A Catterall	Annu Rev Cell Dev Biol	2000	11031246	No
1237	1703	1703.0	54.11	54.1	Social determinants of health inequalities.	Michael Marmot	Lancet	2005	15781105	Yes
1238	3403	1701.5	90.79	45.4	Cloned glutamate receptors.	M Hollmann, S Heinemann	Annu Rev Neurosci	1994	8210177	No
1239	1700	1700.0	0.0	0.0	Protein denaturation.	C Tanford	Adv Protein Chem	1968	4882248	No
1240	1700	1700.0	43.25	43.2	Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures.	D Lavanchy	J Viral Hepat	2004	14996343	No
1241	1699	1699.0	0.0	0.0	Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.	E M Witkin	Bacteriol Rev	1976	795416	No
1242	3396	1698.0	93.69	46.8	Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction.	K B Mullis, F A Faloona	Methods Enzymol	1987	3431465	Yes
1243	1697	1697.0	0.0	0.0	Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry.	M Wong-Riley	Brain Res	1979	223730	Yes
1244	1697	1697.0	0.0	0.0	A graphic method for the determination and presentation of binding parameters in a complex system.	H E Rosenthal	Anal Biochem	1967	6048188	Yes
1245	1696	1696.0	57.08	57.1	Epidemiological features of chronic low-back pain.	G B Andersson	Lancet	1999	10470716	No
1246	1695	1695.0	54.5	54.5	Glutamate: a neurotransmitter in mammalian brain.	F Fonnum	J Neurochem	1984	6139418	No
1247	1694	1694.0	63.49	63.5	Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury.	D R Janero	Free Radic Biol Med	1990	2079232	No
1248	3388	1694.0	72.43	36.2	Identification of common molecular subsequences.	T F Smith, M S Waterman	J Mol Biol	1981	7265238	Yes
1249	1694	1694.0	35.72	35.7	MicroRNA biogenesis: coordinated cropping and dicing.	V Narry Kim	Nat Rev Mol Cell Biol	2005	15852042	No
1250	1694	1694.0	42.01	42.0	Integrating cell-signalling pathways with NF-kappaB and IKK function.	Neil D Perkins	Nat Rev Mol Cell Biol	2007	17183360	No
1251	1693	1693.0	38.29	38.3	The distribution of secondary growths in cancer of the breast. 1889.	S Paget	Cancer Metastasis Rev	1989	2673568	No
1252	1693	1693.0	44.64	44.6	Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.	G C Walker	Microbiol Rev	1984	6371470	No
1253	3383	1691.5	86.24	43.1	Matrix metalloproteinases.	H Nagase, J F Woessner	J Biol Chem	1999	10419448	No
1254	1691	1691.0	58.09	58.1	Large-scale neurocognitive networks and distributed processing for attention, language, and memory.	M M Mesulam	Ann Neurol	1990	2260847	No
1255	1691	1691.0	0.0	0.0	Method for the determination of hexosamines in tissues.	N F Boas	J Biol Chem	1953	13117829	Yes
1256	1689	1689.0	56.6	56.6	Pineal melatonin: cell biology of its synthesis and of its physiological interactions.	R J Reiter	Endocr Rev	1991	1649044	No
1257	1689	1689.0	45.75	45.8	Integrins.	E Ruoslahti	J Clin Invest	1991	1985087	No
1258	1689	1689.0	54.26	54.3	Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.	M Zasloff	Proc Natl Acad Sci U S A	1987	3299384	Yes
1259	1689	1689.0	0.0	0.0	Transplacental carcinogenesis by stilbestrol.	J Folkman	N Engl J Med	1971	5556579	Yes
1260	3377	1688.5	0.0	0.0	A "Direct-Coloring" Thiocholine Method For Cholinesterases.	M J Karnovsky, L Roots	J Histochem Cytochem	1964	14187330	Yes
1261	1687	1687.0	0.0	0.0	Determination of free amino groups in proteins by trinitrobenzenesulfonic acid.	A F Habeeb	Anal Biochem	1966	4161471	Yes
1262	1687	1687.0	57.87	57.9	Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes.	C E Mogensen	N Engl J Med	1984	6690964	Yes
1263	1687	1687.0	0.0	0.0	Dendritic organization in the neurons of the visual and motor cortices of the cat.	D A Sholl	J Anat	1953	13117757	Yes
1264	1686	1686.0	31.76	31.8	How eukaryotic transcriptional activators work.	M Ptashne	Nature	1988	3050531	No
1265	5058	1686.0	100.11	33.4	Surfing the p53 network.	B Vogelstein, D Lane, A J Levine	Nature	2000	11099028	No
1266	1686	1686.0	36.41	36.4	Mechanisms of cancer drug resistance.	Michael M Gottesman	Annu Rev Med	2002	11818492	No
1267	1686	1686.0	36.42	36.4	Molecular regulation of vessel maturation.	Rakesh K Jain	Nat Med	2003	12778167	No
1268	1684	1684.0	0.0	0.0	Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.	A Krishan	J Cell Biol	1975	49354	Yes
1269	1684	1684.0	44.81	44.8	Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver.	Scott L Friedman	Physiol Rev	2008	18195085	No
1270	3365	1682.5	96.46	48.2	Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium.	Kresse, Hafner	Phys Rev B Condens Matter	1994	10010505	Yes
1271	1682	1682.0	40.69	40.7	The molecular genetics of cancer.	J M Bishop	Science	1987	3541204	No
1272	1681	1681.0	0.0	0.0	Why genes in pieces?	W Gilbert	Nature	1978	622185	Yes
1273	1681	1681.0	0.0	0.0	Plastic Embedding Mixtures For Use In Electron Microscopy.	H H Mollenhauer	Stain Technol	1964	14127791	Yes
1274	16801	1680.1	534.08	53.4	Measurement of protein using bicinchoninic acid.	P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C Klenk	Anal Biochem	1985	3843705	Yes
1275	11761	1680.1	295.59	42.2	Induction of pluripotent stem cells from adult human fibroblasts by defined factors.	Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka	Cell	2007	18035408	Yes
1276	1680	1680.0	0.0	0.0	The theory and applications of the exchange of inert gas at the lungs and tissues.	S S Kety	Pharmacol Rev	1951	14833874	Yes
1277	1679	1679.0	40.93	40.9	Type III protein secretion systems in bacterial pathogens of animals and plants.	C J Hueck	Microbiol Mol Biol Rev	1998	9618447	No
1278	3356	1678.0	149.47	74.7	The MOS social support survey.	C D Sherbourne, A L Stewart	Soc Sci Med	1991	2035047	Yes
1279	3356	1678.0	0.0	0.0	Receptive fields and functional architecture of monkey striate cortex.	D H Hubel, T N Wiesel	J Physiol	1968	4966457	Yes
1280	1674	1674.0	0.0	0.0	Evolutionary rate at the molecular level.	M Kimura	Nature	1968	5637732	Yes
1281	3348	1674.0	94.26	47.1	Biochemistry of multidrug resistance mediated by the multidrug transporter.	M M Gottesman, I Pastan	Annu Rev Biochem	1993	8102521	No
1282	1674	1674.0	0.0	0.0	The general adaptation syndrome and the diseases of adaptation.	H Selye	J Clin Endocrinol Metab	1946	21025115	Yes
1283	1674	1674.0	77.16	77.2	Role of nrf2 in oxidative stress and toxicity.	Qiang Ma	Annu Rev Pharmacol Toxicol	2013	23294312	No
1284	1673	1673.0	70.46	70.5	Perception of risk.	P Slovic	Science	1987	3563507	Yes
1285	1673	1673.0	0.0	0.0	An improved procedure for serum creatine phosphokinase determination.	S B Rosalki	J Lab Clin Med	1967	4381359	Yes
1286	5018	1672.7	115.95	38.6	Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR.	Michael W Pfaffl, Graham W Horgan, Leo Dempfle	Nucleic Acids Res	2002	11972351	Yes
1287	1672	1672.0	48.28	48.3	Biofilms: microbial life on surfaces.	Rodney M Donlan	Emerg Infect Dis	2002	12194761	No
1288	1671	1671.0	0.0	0.0	Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.	J A Miller	Cancer Res	1970	4915745	No
1289	3341	1670.5	132.55	66.3	The biofilm matrix.	Hans-Curt Flemming, Jost Wingender	Nat Rev Microbiol	2010	20676145	No
1290	1670	1670.0	60.93	60.9	Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts).	G G Glenner	N Engl J Med	1980	6154243	No
1291	8349	1669.8	233.09	46.6	Global prevalence of diabetes: estimates for the year 2000 and projections for 2030.	Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary King	Diabetes Care	2004	15111519	Yes
1292	6678	1669.5	0.0	0.0	Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.	E A Jaffe, R L Nachman, C G Becker, C R Minick	J Clin Invest	1973	4355998	Yes
1293	1669	1669.0	0.0	0.0	Drugs which inhibit prostaglandin biosynthesis.	R J Flower	Pharmacol Rev	1974	4208101	Yes
1294	3338	1669.0	0.0	0.0	The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties.	T Omura, R Sato	J Biol Chem	1964	14209972	Yes
1295	1669	1669.0	0.0	0.0	Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate.	J Spizizen	Proc Natl Acad Sci U S A	1958	16590310	Yes
1296	1666	1666.0	40.57	40.6	Evolutionary relationship of DNA sequences in finite populations.	F Tajima	Genetics	1983	6628982	Yes
1297	1666	1666.0	69.84	69.8	Doxil®--the first FDA-approved nano-drug: lessons learned.	Yechezkel Barenholz	J Control Release	2012	22484195	No
1298	1664	1664.0	52.82	52.8	The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions.	B L Fredrickson	Am Psychol	2001	11315248	Yes
1299	1664	1664.0	0.0	0.0	Chromatographic Separation Of Human Brain Gangliosides.	L Svennerholm	J Neurochem	1963	14066623	Yes
1300	1663	1663.0	58.19	58.2	Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.	A H Conney	Cancer Res	1982	6814745	No
1301	1663	1663.0	39.79	39.8	Fabrication of novel biomaterials through molecular self-assembly.	Shuguang Zhang	Nat Biotechnol	2003	14520402	No
1302	1663	1663.0	35.43	35.4	DNA methylation and human disease.	Keith D Robertson	Nat Rev Genet	2005	16136652	No
1303	1661	1661.0	0.0	0.0	Areas, volumes, packing and protein structure.	F M Richards	Annu Rev Biophys Bioeng	1977	326146	No
1304	3322	1661.0	0.0	0.0	Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.	M Grunstein, D S Hogness	Proc Natl Acad Sci U S A	1975	1105573	Yes
1305	1661	1661.0	56.25	56.2	The crisis in antibiotic resistance.	H C Neu	Science	1992	1509257	No
1306	1661	1661.0	67.69	67.7	Predicting basal metabolic rate, new standards and review of previous work.	W N Schofield	Hum Nutr Clin Nutr	1985	4044297	Yes
1307	1661	1661.0	39.37	39.4	Solvent-accessible surfaces of proteins and nucleic acids.	M L Connolly	Science	1983	6879170	Yes
1308	3322	1661.0	0.0	0.0	Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature.	J Marmur, P Doty	J Mol Biol	1962	14470099	Yes
1309	1660	1660.0	56.28	56.3	Serum albumin.	T Peters	Adv Protein Chem	1985	3904348	No
1310	1660	1660.0	58.28	58.3	Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?	B Halliwell	Lancet	1994	7915779	No
1311	1660	1660.0	84.48	84.5	Microplastics in the marine environment.	Anthony L Andrady	Mar Pollut Bull	2011	21742351	No
1312	1659	1659.0	38.89	38.9	The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.	D M Kingsley	Genes Dev	1994	8299934	No
1313	1659	1659.0	49.1	49.1	Flavonoids as antioxidants.	P G Pietta	J Nat Prod	2000	10924197	No
1314	1658	1658.0	0.0	0.0	Mode of cell migration to the superficial layers of fetal monkey neocortex.	P Rakic	J Comp Neurol	1972	4624784	Yes
1315	1658	1658.0	37.17	37.2	Exploring complex networks.	S H Strogatz	Nature	2001	11258382	No
1316	3311	1655.5	72.25	36.1	Integrin signaling.	F G Giancotti, E Ruoslahti	Science	1999	10446041	No
1317	1655	1655.0	44.74	44.7	What is cognitive reserve? Theory and research application of the reserve concept.	Yaakov Stern	J Int Neuropsychol Soc	2002	11939702	No
1318	1654	1654.0	0.0	0.0	Carbonic anhydrase: chemistry, physiology, and inhibition.	T H Maren	Physiol Rev	1967	4964060	No
1319	1654	1654.0	34.38	34.4	Cancer and the chemokine network.	Fran Balkwill	Nat Rev Cancer	2004	15229479	No
1320	1647	1647.0	0.0	0.0	Pedigrees of some mutant strains of Escherichia coli K-12.	B J Bachmann	Bacteriol Rev	1972	4568763	No
1321	1645	1645.0	37.49	37.5	Effects of cytochalasin and phalloidin on actin.	J A Cooper	J Cell Biol	1987	3312229	No
1322	6579	1644.8	153.14	38.3	Use of T7 RNA polymerase to direct expression of cloned genes.	F W Studier, A H Rosenberg, J J Dunn, J W Dubendorff	Methods Enzymol	1990	2199796	Yes
1323	3288	1644.0	85.36	42.7	Receptors for purines and pyrimidines.	V Ralevic, G Burnstock	Pharmacol Rev	1998	9755289	No
1324	1644	1644.0	0.0	0.0	A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma.	D Mattingly	J Clin Pathol	1962	14471419	Yes
1325	3287	1643.5	106.59	53.3	Efficient pseudopotentials for plane-wave calculations.	Troullier, Martins	Phys Rev B Condens Matter	1991	9997467	Yes
1326	11502	1643.1	425.24	60.7	Assessing the quality of reports of randomized clinical trials: is blinding necessary?	A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuay	Control Clin Trials	1996	8721797	Yes
1327	3286	1643.0	109.19	54.6	Role of free radicals and catalytic metal ions in human disease: an overview.	B Halliwell, J M Gutteridge	Methods Enzymol	1990	2172697	No
1328	1643	1643.0	51.44	51.4	Inhibited spontaneous emission in solid-state physics and electronics.	Yablonovitch	Phys Rev Lett	1987	10034639	Yes
1329	1641	1641.0	34.16	34.2	Structural features in eukaryotic mRNAs that modulate the initiation of translation.	M Kozak	J Biol Chem	1991	1939050	No
1330	1641	1641.0	46.67	46.7	Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic.	Robert E Marx	J Oral Maxillofac Surg	2003	12966493	Yes
1331	3281	1640.5	102.79	51.4	Nonparametric statistical testing of EEG- and MEG-data.	Eric Maris, Robert Oostenveld	J Neurosci Methods	2007	17517438	Yes
1332	1640	1640.0	45.86	45.9	Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution.	H LeVine	Protein Sci	1993	8453378	Yes
1333	1640	1640.0	49.75	49.8	Intestinal mucosal barrier function in health and disease.	Jerrold R Turner	Nat Rev Immunol	2009	19855405	No
1334	3279	1639.5	76.15	38.1	Amino acid substitution matrices from protein blocks.	S Henikoff, J G Henikoff	Proc Natl Acad Sci U S A	1992	1438297	Yes
1335	3275	1637.5	0.0	0.0	Method for the isolation of intact islets of Langerhans from the rat pancreas.	P E Lacy, M Kostianovsky	Diabetes	1967	5333500	Yes
1336	3275	1637.5	143.63	71.8	A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity.	J G Snodgrass, M Vanderwart	J Exp Psychol Hum Learn	1980	7373248	Yes
1337	3275	1637.5	81.17	40.6	Liver fibrosis.	Ramón Bataller, David A Brenner	J Clin Invest	2005	15690074	No
1338	1637	1637.0	44.25	44.2	Dengue and dengue hemorrhagic fever.	D J Gubler	Clin Microbiol Rev	1998	9665979	No
1339	6545	1636.2	163.71	40.9	Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.	C A Lipinski, F Lombardo, B W Dominy, P J Feeney	Adv Drug Deliv Rev	2001	11259830	No
1340	1636	1636.0	45.53	45.5	Turnover of inositol phospholipids and signal transduction.	Y Nishizuka	Science	1984	6147898	No
1341	6539	1634.8	272.79	68.2	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	J Clin Epidemiol	2009	19631508	No
1342	1634	1634.0	34.9	34.9	The effect of infections on susceptibility to autoimmune and allergic diseases.	Jean-Francois Bach	N Engl J Med	2002	12239261	No
1343	1634	1634.0	60.56	60.6	Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium.	Sergio Pecorelli	Int J Gynaecol Obstet	2009	19367689	No
1344	1634	1634.0	49.6	49.6	MYC on the path to cancer.	Chi V Dang	Cell	2012	22464321	No
1345	3264	1632.0	74.19	37.1	Monocyte and macrophage heterogeneity.	Siamon Gordon, Philip R Taylor	Nat Rev Immunol	2005	16322748	No
1346	3264	1632.0	110.85	55.4	Wnt/β-catenin signaling and disease.	Hans Clevers, Roel Nusse	Cell	2012	22682243	No
1347	3263	1631.5	88.53	44.3	Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering	Nie, Emory	Science	1997	9027306	Yes
1348	1631	1631.0	52.47	52.5	Metallothionein.	D H Hamer	Annu Rev Biochem	1986	3527054	No
1349	6524	1631.0	267.52	66.9	Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses.	Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg Lang	Behav Res Methods	2009	19897823	Yes
1350	1630	1630.0	0.0	0.0	The micronucleus test.	W Schmid	Mutat Res	1975	48190	Yes
1351	3259	1629.5	78.88	39.4	The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.	P Angel, M Karin	Biochim Biophys Acta	1991	1751545	No
1352	3259	1629.5	86.19	43.1	Quantum dot bioconjugates for ultrasensitive nonisotopic detection.	W C Chan, S Nie	Science	1998	9748158	Yes
1353	1629	1629.0	52.58	52.6	PsychoPy--Psychophysics software in Python.	Jonathan W Peirce	J Neurosci Methods	2007	17254636	Yes
1354	16281	1628.1	524.0	52.4	The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.	F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S Luthra	Arthritis Rheum	1988	3358796	Yes
1355	1628	1628.0	48.65	48.6	Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996.	E M Wassermann	Electroencephalogr Clin Neurophysiol	1998	9474057	No
1356	3256	1628.0	90.81	45.4	Protein structure prediction on the Web: a case study using the Phyre server.	Lawrence A Kelley, Michael J E Sternberg	Nat Protoc	2009	19247286	Yes
1357	1627	1627.0	38.73	38.7	NADPH oxidase: an update.	B M Babior	Blood	1999	10029572	No
1358	6501	1625.2	133.93	33.5	Stem cells, cancer, and cancer stem cells.	T Reya, S J Morrison, M F Clarke, I L Weissman	Nature	2001	11689955	No
1359	4873	1624.3	165.96	55.3	FastTree 2--approximately maximum-likelihood trees for large alignments.	Morgan N Price, Paramvir S Dehal, Adam P Arkin	PLoS One	2010	20224823	Yes
1360	1624	1624.0	45.29	45.3	An index to quantify an individual's scientific research output.	J E Hirsch	Proc Natl Acad Sci U S A	2005	16275915	Yes
1361	4870	1623.3	156.49	52.2	Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.	H Esterbauer, R J Schaur, H Zollner	Free Radic Biol Med	1991	1937131	No
1362	1623	1623.0	36.28	36.3	Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury.	S L Friedman	J Biol Chem	2000	10644669	No
1363	1623	1623.0	0.0	0.0	Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study.	E G Gray	J Anat	1959	13829103	Yes
1364	3244	1622.0	71.58	35.8	Protein structure comparison by alignment of distance matrices.	L Holm, C Sander	J Mol Biol	1993	8377180	Yes
1365	1622	1622.0	40.13	40.1	Inflammatory bowel disease: etiology and pathogenesis.	C Fiocchi	Gastroenterology	1998	9649475	No
1366	1621	1621.0	51.6	51.6	The atom economy--a search for synthetic efficiency.	B M Trost	Science	1991	1962206	Yes
1367	1621	1621.0	58.63	58.6	Cell damage in the brain: a speculative synthesis.	B K Siesjö	J Cereb Blood Flow Metab	1981	6276420	No
1368	1621	1621.0	31.7	31.7	Cellular roles of DNA topoisomerases: a molecular perspective.	James C Wang	Nat Rev Mol Cell Biol	2002	12042765	No
1369	1620	1620.0	0.0	0.0	RNA-dependent DNA polymerase in virions of RNA tumour viruses.	D Baltimore	Nature	1970	4316300	Yes
1370	1620	1620.0	32.25	32.2	Hox genes in vertebrate development.	R Krumlauf	Cell	1994	7913880	No
1371	1619	1619.0	32.4	32.4	Cell cycle checkpoints: preventing an identity crisis.	S J Elledge	Science	1996	8939848	No
1372	1619	1619.0	45.11	45.1	Oxidative stress hypothesis in Alzheimer's disease.	W R Markesbery	Free Radic Biol Med	1997	9165306	No
1373	1619	1619.0	45.72	45.7	The comet assay for DNA damage and repair: principles, applications, and limitations.	Andrew R Collins	Mol Biotechnol	2004	15004294	No
1374	3237	1618.5	100.81	50.4	Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability.	F Denizot, R Lang	J Immunol Methods	1986	3486233	Yes
1375	6474	1618.5	177.34	44.3	Epithelial-mesenchymal transitions in development and disease.	Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela Nieto	Cell	2009	19945376	No
1376	1618	1618.0	49.05	49.0	Extracellular ATP: effects, sources and fate.	J L Gordon	Biochem J	1986	3006665	No
1377	3235	1617.5	96.04	48.0	The inflammasomes.	Kate Schroder, Jurg Tschopp	Cell	2010	20303873	No
1378	3234	1617.0	79.75	39.9	PRODRG: a tool for high-throughput crystallography of protein-ligand complexes.	Alexander W Schüttelkopf, Daan M F van Aalten	Acta Crystallogr D Biol Crystallogr	2004	15272157	Yes
1379	3231	1615.5	0.0	0.0	New method for quantitative determination of uronic acids.	N Blumenkrantz, G Asboe-Hansen	Anal Biochem	1973	4269305	Yes
1380	1615	1615.0	46.55	46.5	Cell biology and molecular basis of denitrification.	W G Zumft	Microbiol Mol Biol Rev	1997	9409151	No
1381	1614	1614.0	41.23	41.2	Episodic memory: from mind to brain.	Endel Tulving	Annu Rev Psychol	2002	11752477	Yes
1382	1614	1614.0	54.97	55.0	Global epidemiology of oral and oropharyngeal cancer.	Saman Warnakulasuriya	Oral Oncol	2009	18804401	No
1383	1613	1613.0	41.89	41.9	Neurotrophins and neuronal plasticity.	H Thoenen	Science	1995	7570017	No
1384	1613	1613.0	41.1	41.1	Clinical application of C-reactive protein for cardiovascular disease detection and prevention.	Paul M Ridker	Circulation	2003	12551853	No
1385	1613	1613.0	44.87	44.9	Chlorpromazine equivalent doses for the newer atypical antipsychotics.	Scott W Woods	J Clin Psychiatry	2003	12823080	No
1386	1612	1612.0	70.66	70.7	Neurogenetic adaptive mechanisms in alcoholism.	C R Cloninger	Science	1987	2882604	Yes
1387	1612	1612.0	37.05	37.0	Cellular oncogenes and retroviruses.	J M Bishop	Annu Rev Biochem	1983	6351725	No
1388	3222	1611.0	127.76	63.9	Assays of glutathione peroxidase.	L Flohé, W A Günzler	Methods Enzymol	1984	6727659	Yes
1389	3220	1610.0	0.0	0.0	A fluorometric method for determination of oxidized and reduced glutathione in tissues.	P J Hissin, R Hilf	Anal Biochem	1976	962076	Yes
1390	1610	1610.0	67.46	67.5	Negative symptoms in schizophrenia. Definition and reliability.	N C Andreasen	Arch Gen Psychiatry	1982	7165477	Yes
1391	3218	1609.0	85.39	42.7	Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.	Christian Haass, Dennis J Selkoe	Nat Rev Mol Cell Biol	2007	17245412	No
1392	1608	1608.0	50.84	50.8	Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage.	D W Choi	Trends Neurosci	1988	2469166	No
1393	9647	1607.8	278.58	46.4	Positional cloning of the mouse obese gene and its human homologue.	Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M Friedman	Nature	1994	7984236	Yes
1394	3211	1605.5	75.72	37.9	Parkinson's disease: mechanisms and models.	William Dauer, Serge Przedborski	Neuron	2003	12971891	No
1395	1604	1604.0	43.31	43.3	Using circular dichroism spectra to estimate protein secondary structure.	Norma J Greenfield	Nat Protoc	2006	17406547	Yes
1396	3207	1603.5	89.39	44.7	Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes.	Steven E Nissen, Kathy Wolski	N Engl J Med	2007	17517853	Yes
1397	1603	1603.0	0.0	0.0	Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion.	O Ouchterlony	Acta Pathol Microbiol Scand	1953	13079779	Yes
1398	1603	1603.0	44.83	44.8	Network pharmacology: the next paradigm in drug discovery.	Andrew L Hopkins	Nat Chem Biol	2008	18936753	No
1399	3205	1602.5	77.18	38.6	Rapid and sensitive protein similarity searches.	D J Lipman, W R Pearson	Science	1985	2983426	Yes
1400	1602	1602.0	47.21	47.2	Metalloproteinases and their inhibitors in matrix remodeling.	L M Matrisian	Trends Genet	1990	2132731	No
1401	8008	1601.6	210.68	42.1	Mapping and quantifying mammalian transcriptomes by RNA-Seq.	Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara Wold	Nat Methods	2008	18516045	Yes
1402	1601	1601.0	0.0	0.0	Chromatin structure: a repeating unit of histones and DNA.	R D Kornberg	Science	1974	4825889	Yes
1403	1601	1601.0	50.52	50.5	A measure of population subdivision based on microsatellite allele frequencies.	M Slatkin	Genetics	1995	7705646	Yes
1404	1601	1601.0	29.86	29.9	Maximum-likelihood density modification.	T C Terwilliger	Acta Crystallogr D Biol Crystallogr	2000	10944333	Yes
1405	3196	1598.0	0.0	0.0	Determination of malonaldehyde precursor in tissues by thiobarbituric acid test.	M Mihara, M Uchiyama	Anal Biochem	1978	655387	Yes
1406	1598	1598.0	35.23	35.2	Bone morphogenetic proteins: multifunctional regulators of vertebrate development.	B L Hogan	Genes Dev	1996	8682290	No
1407	1598	1598.0	43.57	43.6	The genetics of ageing.	Cynthia J Kenyon	Nature	2010	20336132	No
1408	1597	1597.0	30.33	30.3	Cyclin-dependent kinases: engines, clocks, and microprocessors.	D O Morgan	Annu Rev Cell Dev Biol	1997	9442875	No
1409	1596	1596.0	36.93	36.9	VLA proteins in the integrin family: structures, functions, and their role on leukocytes.	M E Hemler	Annu Rev Immunol	1990	2188667	No
1410	3191	1595.5	92.36	46.2	ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT.	B Ravel, M Newville	J Synchrotron Radiat	2005	15968136	Yes
1411	3189	1594.5	0.0	0.0	Variations in the pattern of pubertal changes in boys.	W A Marshall, J M Tanner	Arch Dis Child	1970	5440182	Yes
1412	3189	1594.5	63.33	31.7	Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene.	M E Greenberg, E B Ziff	Nature	1984	6090941	Yes
1413	3187	1593.5	63.78	31.9	Automated MAD and MIR structure solution.	T C Terwilliger, J Berendzen	Acta Crystallogr D Biol Crystallogr	1999	10089316	Yes
1414	1592	1592.0	55.86	55.9	Grounded cognition.	Lawrence W Barsalou	Annu Rev Psychol	2008	17705682	No
1415	3178	1589.0	89.55	44.8	The mirror-neuron system.	Giacomo Rizzolatti, Laila Craighero	Annu Rev Neurosci	2004	15217330	No
1416	1587	1587.0	31.68	31.7	An analysis of vertebrate mRNA sequences: intimations of translational control.	M Kozak	J Cell Biol	1991	1955461	No
1417	1587	1587.0	48.3	48.3	Classification of inflammatory bowel disease.	J E Lennard-Jones	Scand J Gastroenterol Suppl	1989	2617184	Yes
1418	3171	1585.5	91.23	45.6	Biofilms: survival mechanisms of clinically relevant microorganisms.	Rodney M Donlan, J William Costerton	Clin Microbiol Rev	2002	11932229	No
1419	1585	1585.0	37.81	37.8	Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems.	S A Bustin	J Mol Endocrinol	2002	12200227	No
1420	1584	1584.0	57.73	57.7	Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.	P Holzer	Pharmacol Rev	1991	1852779	No
1421	3168	1584.0	113.38	56.7	Avoiding false positives with PCR.	S Kwok, R Higuchi	Nature	1989	2716852	Yes
1422	1584	1584.0	0.0	0.0	The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept.	A G Pearse	J Histochem Cytochem	1969	4143745	No
1423	1584	1584.0	0.0	0.0	Structural considerations in the interaction of DNA and acridines.	L S Lerman	J Mol Biol	1961	13761054	Yes
1424	1583	1583.0	0.0	0.0	Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment.	K O Fagerström	Addict Behav	1978	735910	Yes
1425	1583	1583.0	39.98	40.0	Tumor necrosis factor (TNF).	L J Old	Science	1985	2413547	Yes
1426	1583	1583.0	34.67	34.7	The caveolae membrane system.	R G Anderson	Annu Rev Biochem	1998	9759488	No
1427	3162	1581.0	78.26	39.1	CAP3: A DNA sequence assembly program.	X Huang, A Madan	Genome Res	1999	10508846	Yes
1428	1580	1580.0	45.61	45.6	Ionic dependence of glutamate neurotoxicity.	D W Choi	J Neurosci	1987	2880938	Yes
1429	1580	1580.0	0.0	0.0	Computerized transverse axial scanning (tomography). 1. Description of system.	G N Hounsfield	Br J Radiol	1973	4757352	Yes
1430	1580	1580.0	53.48	53.5	Number of people with glaucoma worldwide.	H A Quigley	Br J Ophthalmol	1996	8695555	No
1431	4738	1579.3	113.65	37.9	Inflammation and atherosclerosis.	Peter Libby, Paul M Ridker, Attilio Maseri	Circulation	2002	11877368	No
1432	1579	1579.0	0.0	0.0	Interhemispheric differences in the localization of psychological processes in man.	B Milner	Br Med Bull	1971	4937273	No
1433	1579	1579.0	32.95	33.0	The synaptic vesicle cycle.	Thomas C Sudhof	Annu Rev Neurosci	2004	15217342	No
1434	1579	1579.0	40.74	40.7	Angiogenesis: an organizing principle for drug discovery?	Judah Folkman	Nat Rev Drug Discov	2007	17396134	No
1435	3157	1578.5	68.17	34.1	Inhibitors of mammalian G1 cyclin-dependent kinases.	C J Sherr, J M Roberts	Genes Dev	1995	7758941	No
1436	11045	1577.9	286.48	40.9	Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.	William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan	N Engl J Med	2002	11832527	Yes
1437	3155	1577.5	78.19	39.1	A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes.	S Tabor, C C Richardson	Proc Natl Acad Sci U S A	1985	3156376	Yes
1438	6302	1575.5	171.26	42.8	Cancer-related inflammation.	Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill	Nature	2008	18650914	No
1439	1575	1575.0	41.53	41.5	Alpha-crystallin can function as a molecular chaperone.	J Horwitz	Proc Natl Acad Sci U S A	1992	1438232	Yes
1440	1575	1575.0	53.9	53.9	Hypoxia-inducible factors in physiology and medicine.	Gregg L Semenza	Cell	2012	22304911	No
1441	1573	1573.0	46.3	46.3	Perceptual symbol systems.	L W Barsalou	Behav Brain Sci	1999	11301525	No
1442	1572	1572.0	34.57	34.6	Excitatory actions of gaba during development: the nature of the nurture.	Yehezkel Ben-Ari	Nat Rev Neurosci	2002	12209121	No
1443	1572	1572.0	48.77	48.8	Infrared spectroscopy of proteins.	Andreas Barth	Biochim Biophys Acta	2007	17692815	No
1444	3144	1572.0	91.6	45.8	Building better batteries.	M Armand, J-M Tarascon	Nature	2008	18256660	No
1445	3143	1571.5	63.58	31.8	SIFT: Predicting amino acid changes that affect protein function.	Pauline C Ng, Steven Henikoff	Nucleic Acids Res	2003	12824425	Yes
1446	3142	1571.0	88.51	44.3	Polyamines.	C W Tabor, H Tabor	Annu Rev Biochem	1984	6206782	No
1447	1570	1570.0	0.0	0.0	Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.	B Hille	J Gen Physiol	1977	300786	Yes
1448	1570	1570.0	52.4	52.4	Biology of interleukin 1.	C A Dinarello	FASEB J	1988	3277884	No
1449	4708	1569.3	104.53	34.8	Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.	J E Darnell, I M Kerr, G R Stark	Science	1994	8197455	No
1450	3138	1569.0	140.28	70.1	miRBase: annotating high confidence microRNAs using deep sequencing data.	Ana Kozomara, Sam Griffiths-Jones	Nucleic Acids Res	2014	24275495	Yes
1451	4706	1568.7	145.69	48.6	Atrial fibrillation as an independent risk factor for stroke: the Framingham Study.	P A Wolf, R D Abbott, W B Kannel	Stroke	1991	1866765	Yes
1452	1568	1568.0	0.0	0.0	Regulation of noradrenaline release by presynaptic receptor systems.	K Starke	Rev Physiol Biochem Pharmacol	1977	14389	No
1453	3135	1567.5	69.75	34.9	Insulin signalling and the regulation of glucose and lipid metabolism.	A R Saltiel, C R Kahn	Nature	2001	11742412	Yes
1454	1567	1567.0	0.0	0.0	Paced auditory serial-addition task: a measure of recovery from concussion.	D M Gronwall	Percept Mot Skills	1977	866038	Yes
1455	1566	1566.0	0.0	0.0	The estimation of phosphorus.	R J Allen	Biochem J	1940	16747230	Yes
1456	3131	1565.5	97.58	48.8	Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.	D S Bredt, S H Snyder	Proc Natl Acad Sci U S A	1990	1689048	Yes
1457	1564	1564.0	72.04	72.0	Mood and memory.	G H Bower	Am Psychol	1981	7224324	Yes
1458	1563	1563.0	0.0	0.0	Fluorescence energy transfer as a spectroscopic ruler.	L Stryer	Annu Rev Biochem	1978	354506	No
1459	1563	1563.0	34.31	34.3	On finding all suboptimal foldings of an RNA molecule.	M Zuker	Science	1989	2468181	No
1460	1563	1563.0	61.99	62.0	Modeling and variable selection in epidemiologic analysis.	S Greenland	Am J Public Health	1989	2916724	Yes
1461	1563	1563.0	0.0	0.0	A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin.	B C Hummel	Can J Biochem Physiol	1959	14405350	Yes
1462	1563	1563.0	39.89	39.9	Tumor angiogenesis.	Robert S Kerbel	N Engl J Med	2008	18463380	No
1463	1562	1562.0	55.39	55.4	Frontal-subcortical circuits and human behavior.	J L Cummings	Arch Neurol	1993	8352676	No
1464	1562	1562.0	33.34	33.3	Points of control in inflammation.	Carl Nathan	Nature	2002	12490957	No
1465	3123	1561.5	0.0	0.0	Convergent and discriminant validation by the multitrait-multimethod matrix.	D T Campbell, D W Fiske	Psychol Bull	1959	13634291	Yes
1466	1561	1561.0	0.0	0.0	Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection.	W H Oldendorf	Am J Physiol	1971	5124307	Yes
1467	1561	1561.0	41.8	41.8	Adipose tissue, adipokines, and inflammation.	Giamila Fantuzzi	J Allergy Clin Immunol	2005	15867843	No
1468	1560	1560.0	44.38	44.4	Leptospirosis.	P N Levett	Clin Microbiol Rev	2001	11292640	No
1469	1560	1560.0	32.64	32.6	Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.	Judith Campisi	Cell	2005	15734683	No
1470	4679	1559.7	102.32	34.1	A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays.	Zhang, Chung, Oldenburg	J Biomol Screen	1999	10838414	Yes
1471	1559	1559.0	42.97	43.0	The complete general secretory pathway in gram-negative bacteria.	A P Pugsley	Microbiol Rev	1993	8096622	No
1472	3118	1559.0	0.0	0.0	A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues.	G Schmidt, S J Thannhauser	J Biol Chem	1945	21005717	Yes
1473	1558	1558.0	0.0	0.0	The relationship between the spleen colony-forming cell and the haemopoietic stem cell.	R Schofield	Blood Cells	1978	747780	Yes
1474	1558	1558.0	34.38	34.4	Protein homology detection by HMM-HMM comparison.	Johannes Söding	Bioinformatics	2005	15531603	Yes
1475	1558	1558.0	44.62	44.6	Oxidative stress and neurodegeneration: where are we now?	Barry Halliwell	J Neurochem	2006	16805774	No
1476	1557	1557.0	35.87	35.9	The proto-oncogene Bcl-2 and its role in regulating apoptosis.	G Kroemer	Nat Med	1997	9176486	No
1477	1557	1557.0	31.52	31.5	Generating samples under a Wright-Fisher neutral model of genetic variation.	Richard R Hudson	Bioinformatics	2002	11847089	Yes
1478	4667	1555.7	132.98	44.3	Cell death: the significance of apoptosis.	A H Wyllie, J F Kerr, A R Currie	Int Rev Cytol	1980	7014501	No
1479	4667	1555.7	189.51	63.2	The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs.	C A McHorney, J E Ware, A E Raczek	Med Care	1993	8450681	Yes
1480	1555	1555.0	37.4	37.4	Recognition of microorganisms and activation of the immune response.	Ruslan Medzhitov	Nature	2007	17943118	No
1481	1554	1554.0	29.82	29.8	Germinal centers.	I C MacLennan	Annu Rev Immunol	1994	8011279	No
1482	1554	1554.0	51.51	51.5	Health consequences of obesity in youth: childhood predictors of adult disease.	W H Dietz	Pediatrics	1998	12224658	No
1483	3107	1553.5	94.26	47.1	Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons.	M Karas, F Hillenkamp	Anal Chem	1988	3239801	Yes
1484	1553	1553.0	52.65	52.6	Archaea in coastal marine environments.	E F DeLong	Proc Natl Acad Sci U S A	1992	1608980	Yes
1485	3102	1551.0	207.45	103.7	A clinical method of functional assessment of the shoulder.	C R Constant, A H Murley	Clin Orthop Relat Res	1987	3791738	Yes
1486	4653	1551.0	105.68	35.2	An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database.	J K Eng, A L McCormack, J R Yates	J Am Soc Mass Spectrom	1994	24226387	Yes
1487	1550	1550.0	49.04	49.0	Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance.	F Rousset	Genetics	1997	9093870	Yes
1488	1550	1550.0	46.18	46.2	Introduction and General Overview of Cyclodextrin Chemistry.	József Szejtli	Chem Rev	1998	11848947	Yes
1489	4648	1549.3	132.25	44.1	The metabolic syndrome--a new worldwide definition.	K George M M Alberti, Paul Zimmet, Jonathan Shaw	Lancet	2005	16182882	Yes
1490	1549	1549.0	40.23	40.2	Molecular biology of prion diseases.	S B Prusiner	Science	1991	1675487	No
1491	1549	1549.0	45.54	45.5	The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function.	R R Llinás	Science	1988	3059497	No
1492	1549	1549.0	60.46	60.5	Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides.	P Holzer	Neuroscience	1988	3288903	No
1493	4647	1549.0	0.0	0.0	A highly sensitive adenylate cyclase assay.	Y Salomon, C Londos, M Rodbell	Anal Biochem	1974	4827395	Yes
1494	1549	1549.0	45.22	45.2	Glycosphingolipids in cellular interaction, differentiation, and oncogenesis.	S Hakomori	Annu Rev Biochem	1981	7023369	No
1495	3097	1548.5	65.81	32.9	A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids.	D Wessel, U I Flügge	Anal Biochem	1984	6731838	Yes
1496	3097	1548.5	105.13	52.6	Understanding interobserver agreement: the kappa statistic.	Anthony J Viera, Joanne M Garrett	Fam Med	2005	15883903	Yes
1497	1548	1548.0	41.89	41.9	Molecular bases of the acute coronary syndromes.	P Libby	Circulation	1995	7758192	No
1498	1547	1547.0	50.2	50.2	Cellular defenses against damage from reactive oxygen species.	B P Yu	Physiol Rev	1994	8295932	No
1499	1546	1546.0	67.06	67.1	The drug abuse screening test.	H A Skinner	Addict Behav	1982	7183189	Yes
1500	1546	1546.0	42.09	42.1	From sensation to cognition.	M M Mesulam	Brain	1998	9648540	No
1501	1546	1546.0	61.15	61.1	Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope.	Lutz Ackermann	Chem Rev	2011	21391562	Yes
1502	3092	1546.0	94.49	47.2	The unfolded protein response: from stress pathway to homeostatic regulation.	Peter Walter, David Ron	Science	2011	22116877	No
1503	3091	1545.5	122.89	61.4	The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger.	A J Stunkard, S Messick	J Psychosom Res	1985	3981480	Yes
1504	1545	1545.0	60.57	60.6	Simple proton spectroscopic imaging.	W T Dixon	Radiology	1984	6089263	Yes
1505	1543	1543.0	38.16	38.2	HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy.	J M Coffin	Science	1995	7824947	Yes
1506	1543	1543.0	50.41	50.4	The stress response in fish.	S E Wendelaar Bonga	Physiol Rev	1997	9234959	No
1507	1543	1543.0	34.13	34.1	Neuronal calcium signaling.	M J Berridge	Neuron	1998	9697848	No
1508	1543	1543.0	50.05	50.0	Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events?	George A Bonanno	Am Psychol	2004	14736317	No
1509	3085	1542.5	90.68	45.3	Oxidative stress, glutamate, and neurodegenerative disorders.	J T Coyle, P Puttfarcken	Science	1993	7901908	No
1510	1542	1542.0	51.51	51.5	Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue').	M N Marsh	Gastroenterology	1992	1727768	No
1511	3084	1542.0	90.39	45.2	Event-related EEG/MEG synchronization and desynchronization: basic principles.	G Pfurtscheller, F H Lopes da Silva	Clin Neurophysiol	1999	10576479	No
1512	1542	1542.0	30.43	30.4	Switching and signaling at the telomere.	E H Blackburn	Cell	2001	11572773	No
1513	1541	1541.0	0.0	0.0	Discharge patterns and functional organization of mammalian retina.	S W Kuffler	J Neurophysiol	1953	13035466	Yes
1514	3081	1540.5	76.81	38.4	Neuronal oscillations in cortical networks.	György Buzsáki, Andreas Draguhn	Science	2004	15218136	No
1515	3077	1538.5	73.04	36.5	Issues and challenges facing rechargeable lithium batteries.	J M Tarascon, M Armand	Nature	2001	11713543	Yes
1516	1538	1538.0	0.0	0.0	Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase.	H S Penefsky	J Biol Chem	1977	16006	Yes
1517	1538	1538.0	39.54	39.5	Cellular basis of working memory.	P S Goldman-Rakic	Neuron	1995	7695894	No
1518	1537	1537.0	34.77	34.8	Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.	C Taswell	J Immunol	1981	7009746	Yes
1519	1537	1537.0	46.45	46.5	Multiple imputation: a primer.	J L Schafer	Stat Methods Med Res	1999	10347857	No
1520	4610	1536.7	103.6	34.5	Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.	M A Frohman, M K Dush, G R Martin	Proc Natl Acad Sci U S A	1988	2461560	Yes
1521	4608	1536.0	0.0	0.0	Impact of Event Scale: a measure of subjective stress.	M Horowitz, N Wilner, W Alvarez	Psychosom Med	1979	472086	Yes
1522	4602	1534.0	118.25	39.4	Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey.	Earl S Ford, Wayne H Giles, William H Dietz	JAMA	2002	11790215	Yes
1523	1534	1534.0	0.0	0.0	Antigen-Antibody Crossed Electrophoresis.	C B Laurell	Anal Biochem	1965	14302464	Yes
1524	1533	1533.0	81.68	81.7	Conservation of resources. A new attempt at conceptualizing stress.	S E Hobfoll	Am Psychol	1989	2648906	No
1525	1533	1533.0	27.5	27.5	Cell cycle checkpoint signaling through the ATM and ATR kinases.	R T Abraham	Genes Dev	2001	11544175	No
1526	1533	1533.0	38.48	38.5	The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.	Michael R Lieber	Annu Rev Biochem	2010	20192759	No
1527	3065	1532.5	0.0	0.0	The structure of coping.	L I Pearlin, C Schooler	J Health Soc Behav	1978	649936	Yes
1528	1532	1532.0	44.5	44.5	Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.	A E Pegg	Cancer Res	1988	3123052	No
1529	1530	1530.0	36.61	36.6	AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.	D Grahame Hardie	Nat Rev Mol Cell Biol	2007	17712357	No
1530	9178	1529.7	217.69	36.3	Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.	D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuire	Science	1987	3798106	Yes
1531	3059	1529.5	84.48	42.2	A scaling normalization method for differential expression analysis of RNA-seq data.	Mark D Robinson, Alicia Oshlack	Genome Biol	2010	20196867	Yes
1532	1529	1529.0	38.96	39.0	Early signals in the mitogenic response.	E Rozengurt	Science	1986	3018928	No
1533	1529	1529.0	39.35	39.4	Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations.	M J Meaney	Annu Rev Neurosci	2001	11520931	No
1534	3057	1528.5	0.0	0.0	Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome.	C B Lozzio, B B Lozzio	Blood	1975	163658	Yes
1535	1527	1527.0	0.0	0.0	An enzymic method for the trace iodination of immunoglobulins and other proteins.	J J Marchalonis	Biochem J	1969	4185494	Yes
1536	1526	1526.0	45.39	45.4	Recent advances in the biochemistry of polyamines in eukaryotes.	A E Pegg	Biochem J	1986	3087344	No
1537	3052	1526.0	71.7	35.9	The epigenomics of cancer.	Peter A Jones, Stephen B Baylin	Cell	2007	17320506	No
1538	3051	1525.5	0.0	0.0	New Giemsa method for the differential staining of sister chromatids.	P Perry, S Wolff	Nature	1974	4138930	Yes
1539	3051	1525.5	103.88	51.9	The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today.	R Doll, R Peto	J Natl Cancer Inst	1981	7017215	No
1540	1525	1525.0	30.62	30.6	E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.	J R Nevins	Science	1992	1411535	Yes
1541	1525	1525.0	34.24	34.2	Molecular themes in oncogenesis.	J M Bishop	Cell	1991	1988146	No
1542	1525	1525.0	42.41	42.4	P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation.	Berk Hess	J Chem Theory Comput	2008	26619985	Yes
1543	1524	1524.0	40.91	40.9	Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp.	D A Dougherty	Science	1996	8539615	No
1544	1524	1524.0	44.74	44.7	The in vitro micronucleus technique.	M Fenech	Mutat Res	2000	11113469	No
1545	1523	1523.0	0.0	0.0	Dithiothreitol, A New Protective Reagent For Sh Groups.	W W Cleland	Biochemistry	1964	14192894	Yes
1546	3043	1521.5	111.96	56.0	ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts.	M Gardes, T D Bruns	Mol Ecol	1993	8180733	Yes
1547	1520	1520.0	70.39	70.4	The contribution of low birth weight to infant mortality and childhood morbidity.	M C McCormick	N Engl J Med	1985	3880598	No
1548	1519	1519.0	41.56	41.6	Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.	L A Liotta	Cancer Res	1986	2998604	No
1549	1518	1518.0	0.0	0.0	Which elements are excited in electrical stimulation of mammalian central nervous system: a review.	J B Ranck	Brain Res	1975	1102064	No
1550	1518	1518.0	27.82	27.8	Altering the genome by homologous recombination.	M R Capecchi	Science	1989	2660260	No
1551	1518	1518.0	38.4	38.4	Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods.	Z Yang	J Mol Evol	1994	7932792	Yes
1552	1518	1518.0	70.91	70.9	Measurement of health state utilities for economic appraisal.	G W Torrance	J Health Econ	1986	10311607	No
1553	9105	1517.5	193.3	32.2	Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.	A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C Mello	Nature	1998	9486653	Yes
1554	1517	1517.0	43.6	43.6	Determination of minimum inhibitory concentrations.	J M Andrews	J Antimicrob Chemother	2001	11420333	Yes
1555	1516	1516.0	0.0	0.0	Calcium release from the sarcoplasmic reticulum.	M Endo	Physiol Rev	1977	13441	Yes
1556	3032	1516.0	80.7	40.4	Origins and Mechanisms of miRNAs and siRNAs.	Richard W Carthew, Erik J Sontheimer	Cell	2009	19239886	No
1557	9081	1513.5	315.39	52.6	Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.	L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R Tannenbaum	Anal Biochem	1982	7181105	Yes
1558	3027	1513.5	64.35	32.2	Upstream and downstream of mTOR.	Nissim Hay, Nahum Sonenberg	Genes Dev	2004	15314020	No
1559	3024	1512.0	100.9	50.5	Separate visual pathways for perception and action.	M A Goodale, A D Milner	Trends Neurosci	1992	1374953	No
1560	1512	1512.0	36.39	36.4	Getting formal with dopamine and reward.	Wolfram Schultz	Neuron	2002	12383780	No
1561	3020	1510.0	0.0	0.0	Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration.	D B Dill, D L Costill	J Appl Physiol	1974	4850854	Yes
1562	1510	1510.0	44.0	44.0	Oxidative stress: oxidants and antioxidants.	H Sies	Exp Physiol	1997	9129943	No
1563	1510	1510.0	37.8	37.8	Python: a programming language for software integration and development.	M F Sanner	J Mol Graph Model	1999	10660911	Yes
1564	3017	1508.5	60.26	30.1	Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.	O Tetsu, F McCormick	Nature	1999	10201372	Yes
1565	3016	1508.0	0.0	0.0	Computed circular dichroism spectra for the evaluation of protein conformation.	N Greenfield, G D Fasman	Biochemistry	1969	5346390	Yes
1566	1508	1508.0	56.95	57.0	Aging, natural death, and the compression of morbidity.	J F Fries	N Engl J Med	1980	7383070	Yes
1567	1508	1508.0	29.09	29.1	How cells read TGF-beta signals.	J Massagué	Nat Rev Mol Cell Biol	2000	11252892	No
1568	1508	1508.0	45.23	45.2	Porous scaffold design for tissue engineering.	Scott J Hollister	Nat Mater	2005	16003400	No
1569	12062	1507.8	320.73	40.1	Electric field effect in atomically thin carbon films.	K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A Firsov	Science	2004	15499015	Yes
1570	1507	1507.0	59.86	59.9	Probiotics in man and animals.	R Fuller	J Appl Bacteriol	1989	2666378	No
1571	1506	1506.0	0.0	0.0	Biological applications of ionophores.	B C Pressman	Annu Rev Biochem	1976	786156	No
1572	1506	1506.0	0.0	0.0	Some observations upon a new inhibitor of monoamine oxidase in brain tissue.	J P Johnston	Biochem Pharmacol	1968	5659776	Yes
1573	1505	1505.0	36.06	36.1	Trastuzumab--mechanism of action and use in clinical practice.	Clifford A Hudis	N Engl J Med	2007	17611206	No
1574	1504	1504.0	66.7	66.7	A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability.	D J Schuirmann	J Pharmacokinet Biopharm	1987	3450848	Yes
1575	3008	1504.0	116.29	58.1	Microenvironmental regulation of tumor progression and metastasis.	Daniela F Quail, Johanna A Joyce	Nat Med	2013	24202395	No
1576	1503	1503.0	41.29	41.3	THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons.	Kozi Asada	Annu Rev Plant Physiol Plant Mol Biol	1999	15012221	Yes
1577	1503	1503.0	52.65	52.6	Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges.	Leonardo Pantoni	Lancet Neurol	2010	20610345	No
1578	4506	1502.0	183.69	61.2	Effect of the damping function in dispersion corrected density functional theory.	Stefan Grimme, Stephan Ehrlich, Lars Goerigk	J Comput Chem	2011	21370243	Yes
1579	3003	1501.5	108.74	54.4	Macrophage plasticity and polarization: in vivo veritas.	Antonio Sica, Alberto Mantovani	J Clin Invest	2012	22378047	No
1580	1501	1501.0	38.02	38.0	Trophic factors and neuronal survival.	Y A Barde	Neuron	1989	2697237	No
1581	1501	1501.0	36.66	36.7	Thiazolidinediones.	Hannele Yki-Järvinen	N Engl J Med	2004	15356308	No
1582	6004	1501.0	232.33	58.1	SignalP 4.0: discriminating signal peptides from transmembrane regions.	Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik Nielsen	Nat Methods	2011	21959131	Yes
1583	4501	1500.3	122.36	40.8	Median-joining networks for inferring intraspecific phylogenies.	H J Bandelt, P Forster, A Röhl	Mol Biol Evol	1999	10331250	Yes
1584	1500	1500.0	42.17	42.2	Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy.	Y Ben-Ari	Neuroscience	1985	2859548	No
1585	1500	1500.0	0.0	0.0	The inverse care law.	J T Hart	Lancet	1971	4100731	Yes
1586	1500	1500.0	30.06	30.1	Neuroblastoma: biological insights into a clinical enigma.	Garrett M Brodeur	Nat Rev Cancer	2003	12612655	No
1587	1499	1499.0	47.49	47.5	The role of the amygdala in fear and anxiety.	M Davis	Annu Rev Neurosci	1992	1575447	No
1588	2998	1499.0	157.94	79.0	Interrater reliability of a modified Ashworth scale of muscle spasticity.	R W Bohannon, M B Smith	Phys Ther	1987	3809245	Yes
1589	1499	1499.0	44.3	44.3	The basal ganglia: focused selection and inhibition of competing motor programs.	J W Mink	Prog Neurobiol	1996	9004351	No
1590	2997	1498.5	74.35	37.2	Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry.	Robert Visse, Hideaki Nagase	Circ Res	2003	12730128	No
1591	2997	1498.5	65.27	32.6	Signaling to NF-kappaB.	Matthew S Hayden, Sankar Ghosh	Genes Dev	2004	15371334	No
1592	1498	1498.0	30.77	30.8	The ubiquitin-proteasome proteolytic pathway.	A Ciechanover	Cell	1994	7923371	No
1593	5992	1498.0	291.27	72.8	jModelTest 2: more models, new heuristics and parallel computing.	Diego Darriba, Guillermo L Taboada, Ramón Doallo, David Posada	Nat Methods	2012	22847109	Yes
1594	1497	1497.0	0.0	0.0	Synaptic density in human frontal cortex - developmental changes and effects of aging.	P R Huttenlocher	Brain Res	1979	427544	Yes
1595	5988	1497.0	0.0	0.0	The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care.	S P Baker, B O'Neill, W Haddon, W B Long	J Trauma	1974	4814394	Yes
1596	1496	1496.0	56.38	56.4	The linear-quadratic formula and progress in fractionated radiotherapy.	J F Fowler	Br J Radiol	1989	2670032	No
1597	1496	1496.0	31.08	31.1	Network motifs: theory and experimental approaches.	Uri Alon	Nat Rev Genet	2007	17510665	No
1598	7471	1494.2	198.8	39.8	Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.	Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan Hsu	N Engl J Med	2004	15385656	Yes
1599	1494	1494.0	0.0	0.0	Dopamine (3-hydroxytyramine) and brain function.	O Hornykiewicz	Pharmacol Rev	1966	5328389	No
1600	1494	1494.0	44.41	44.4	Molecular dissection of reactive astrogliosis and glial scar formation.	Michael V Sofroniew	Trends Neurosci	2009	19782411	No
1601	1493	1493.0	33.64	33.6	Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1.	G L Semenza	Annu Rev Cell Dev Biol	1999	10611972	No
1602	1493	1493.0	30.45	30.4	The microRNA Registry.	Sam Griffiths-Jones	Nucleic Acids Res	2004	14681370	Yes
1603	1493	1493.0	37.08	37.1	The retinal pigment epithelium in visual function.	Olaf Strauss	Physiol Rev	2005	15987797	No
1604	1493	1493.0	46.38	46.4	Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.	Ralph A Defronzo	Diabetes	2009	19336687	No
1605	2985	1492.5	67.29	33.6	Why do cancers have high aerobic glycolysis?	Robert A Gatenby, Robert J Gillies	Nat Rev Cancer	2004	15516961	No
1606	2984	1492.0	93.92	47.0	Autophagy: renovation of cells and tissues.	Noboru Mizushima, Masaaki Komatsu	Cell	2011	22078875	No
1607	8951	1491.8	281.01	46.8	Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication.	Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E Walters	Arch Gen Psychiatry	2005	15939837	Yes
1608	1491	1491.0	39.42	39.4	The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.	A S Fauci	Science	1988	3277274	No
1609	1490	1490.0	0.0	0.0	Bias in analytic research.	D L Sackett	J Chronic Dis	1979	447779	Yes
1610	1490	1490.0	44.24	44.2	Trail Making Test A and B: normative data stratified by age and education.	Tom N Tombaugh	Arch Clin Neuropsychol	2004	15010086	Yes
1611	2979	1489.5	74.21	37.1	The DNA-damage response in human biology and disease.	Stephen P Jackson, Jiri Bartek	Nature	2009	19847258	No
1612	1489	1489.0	38.31	38.3	The corticosteroid receptor hypothesis of depression.	F Holsboer	Neuropsychopharmacology	2000	11027914	No
1613	1489	1489.0	35.39	35.4	Hypertrophic cardiomyopathy: a systematic review.	Barry J Maron	JAMA	2002	11886323	No
1614	1488	1488.0	50.66	50.7	A new automated colorimetric method for measuring total oxidant status.	Ozcan Erel	Clin Biochem	2005	16214125	Yes
1615	1488	1488.0	38.61	38.6	Growth of the plant cell wall.	Daniel J Cosgrove	Nat Rev Mol Cell Biol	2005	16261190	No
1616	2975	1487.5	0.0	0.0	Lactic dehydrogenase activity in blood.	F Wroblewski, J S Ladue	Proc Soc Exp Biol Med	1955	13273400	Yes
1617	1487	1487.0	0.0	0.0	Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.	J C Unkeless	J Exp Med	1979	90108	Yes
1618	2974	1487.0	75.88	37.9	The BCL-2 protein family: opposing activities that mediate cell death.	Richard J Youle, Andreas Strasser	Nat Rev Mol Cell Biol	2008	18097445	No
1619	1486	1486.0	0.0	0.0	A soluble protein characteristic of the nervous system.	B W Moore	Biochem Biophys Res Commun	1965	4953930	Yes
1620	1486	1486.0	0.0	0.0	Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies.	S Avrameas	Immunochemistry	1969	4975324	Yes
1621	4455	1485.0	95.38	31.8	The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.	S K Hanks, A M Quinn, T Hunter	Science	1988	3291115	No
1622	2969	1484.5	69.44	34.7	Fibroblasts in cancer.	Raghu Kalluri, Michael Zeisberg	Nat Rev Cancer	2006	16572188	No
1623	1484	1484.0	36.68	36.7	Recognition of errors in three-dimensional structures of proteins.	M J Sippl	Proteins	1993	8108378	Yes
1624	1483	1483.0	36.71	36.7	A revolution in optical manipulation.	David G Grier	Nature	2003	12917694	No
1625	4446	1482.0	89.77	29.9	Efficient selection for high-expression transfectants with a novel eukaryotic vector.	H Niwa, K Yamamura, J Miyazaki	Gene	1991	1660837	Yes
1626	2963	1481.5	72.91	36.5	Human mesenchymal stem cells modulate allogeneic immune cell responses.	Sudeepta Aggarwal, Mark F Pittenger	Blood	2005	15494428	Yes
1627	1481	1481.0	52.08	52.1	Lyme disease.	A C Steere	N Engl J Med	1989	2668764	No
1628	1481	1481.0	0.0	0.0	The recurrence of intracranial meningiomas after surgical treatment.	D Simpson	J Neurol Neurosurg Psychiatry	1957	13406590	Yes
1629	1481	1481.0	0.0	0.0	Simple methods for "staining with lead" at high pH in electron microscopy.	M J Karnovsky	J Biophys Biochem Cytol	1961	14454024	Yes
1630	7403	1480.6	186.96	37.4	Development and testing of a general amber force field.	Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A Case	J Comput Chem	2004	15116359	Yes
1631	2960	1480.0	82.04	41.0	Angiogenesis.	J Folkman, Y Shing	J Biol Chem	1992	1375931	No
1632	1480	1480.0	44.02	44.0	What we can do and what we cannot do with fMRI.	Nikos K Logothetis	Nature	2008	18548064	No
1633	1479	1479.0	0.0	0.0	Application of a Theory of Enzyme Specificity to Protein Synthesis.	D E Koshland	Proc Natl Acad Sci U S A	1958	16590179	Yes
1634	1478	1478.0	0.0	0.0	Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report.	C S Neer	J Bone Joint Surg Am	1972	5054450	Yes
1635	1477	1477.0	33.63	33.6	Tumor suppressor genes.	R A Weinberg	Science	1991	1659741	No
1636	1477	1477.0	0.0	0.0	The colorimetric determination of phosphorus.	E J King	Biochem J	1932	16744823	Yes
1637	5902	1475.5	293.31	73.3	The Satisfaction With Life Scale.	E Diener, R A Emmons, R J Larsen, S Griffin	J Pers Assess	1985	16367493	Yes
1638	1475	1475.0	39.93	39.9	Rheumatoid arthritis. Pathophysiology and implications for therapy.	E D Harris	N Engl J Med	1990	2271017	No
1639	2950	1475.0	59.27	29.6	Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins.	P J Mitchell, R Tjian	Science	1989	2667136	No
1640	2950	1475.0	0.0	0.0	The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.	E G Gray, V P Whittaker	J Anat	1962	13901297	Yes
1641	4423	1474.3	154.41	51.5	A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study.	J R Le Gall, S Lemeshow, F Saulnier	JAMA	1993	8254858	Yes
1642	2947	1473.5	62.3	31.1	Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases.	Gary L Johnson, Razvan Lapadat	Science	2002	12471242	No
1643	1473	1473.0	0.0	0.0	Simple memory: a theory for archicortex.	D Marr	Philos Trans R Soc Lond B Biol Sci	1971	4399412	Yes
1644	4418	1472.7	117.1	39.0	Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm.	Prateek Kumar, Steven Henikoff, Pauline C Ng	Nat Protoc	2009	19561590	Yes
1645	1472	1472.0	41.35	41.4	Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum.	A Fabiato	Am J Physiol	1983	6346892	No
1646	16191	1471.9	440.33	40.0	PLINK: a tool set for whole-genome association and population-based linkage analyses.	Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C Sham	Am J Hum Genet	2007	17701901	Yes
1647	1471	1471.0	0.0	0.0	Atherogenesis: a postprandial phenomenon.	D B Zilversmit	Circulation	1979	222498	Yes
1648	1471	1471.0	0.0	0.0	Isolated removal of hypothalamic or other brain nuclei of the rat.	M Palkovits	Brain Res	1973	4747772	Yes
1649	1471	1471.0	0.0	0.0	Cognitive maps in rats and men.	E C Tolman	Psychol Rev	1948	18870876	Yes
1650	2939	1469.5	0.0	0.0	Junctional complexes in various epithelia.	M G Farquhar, G E Palade	J Cell Biol	1963	13944428	Yes
1651	1469	1469.0	0.0	0.0	Cerebral blood flow and oxygen consumption in man.	N A Lassen	Physiol Rev	1959	13645234	Yes
1652	1468	1468.0	35.56	35.6	Introduction to NF-kappaB: players, pathways, perspectives.	T D Gilmore	Oncogene	2006	17072321	No
1653	7335	1467.0	168.97	33.8	Stages of embryonic development of the zebrafish.	C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F Schilling	Dev Dyn	1995	8589427	Yes
1654	1466	1466.0	38.17	38.2	Tricine-SDS-PAGE.	Hermann Schägger	Nat Protoc	2006	17406207	Yes
1655	1466	1466.0	46.16	46.2	Gold-catalyzed organic reactions.	A Stephen K Hashmi	Chem Rev	2007	17580975	Yes
1656	1465	1465.0	49.28	49.3	Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson.	H J Gundersen	J Microsc	1986	3761363	Yes
1657	1465	1465.0	47.0	47.0	Constructions of masculinity and their influence on men's well-being: a theory of gender and health.	W H Courtenay	Soc Sci Med	2000	10741575	No
1658	1464	1464.0	39.38	39.4	Precision mapping of quantitative trait loci.	Z B Zeng	Genetics	1994	8013918	Yes
1659	1464	1464.0	35.8	35.8	The hippo signaling pathway in development and cancer.	Duojia Pan	Dev Cell	2010	20951342	No
1660	2927	1463.5	0.0	0.0	A general method for isolation of high molecular weight DNA from eukaryotes.	N Blin, D W Stafford	Nucleic Acids Res	1976	987581	Yes
1661	2925	1462.5	0.0	0.0	A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines.	A H Anton, D F Sayre	J Pharmacol Exp Ther	1962	14013351	Yes
1662	1462	1462.0	31.78	31.8	DNA in a material world.	Nadrian C Seeman	Nature	2003	12540916	No
1663	4385	1461.7	0.0	0.0	The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes.	J T Dodge, C Mitchell, D J Hanahan	Arch Biochem Biophys	1963	14028302	Yes
1664	4382	1460.7	89.22	29.7	T-Coffee: A novel method for fast and accurate multiple sequence alignment.	C Notredame, D G Higgins, J Heringa	J Mol Biol	2000	10964570	Yes
1665	2921	1460.5	99.12	49.6	Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference.	Stephen M Smith, Thomas E Nichols	Neuroimage	2009	18501637	Yes
1666	2921	1460.5	111.53	55.8	Shifting the genomic gold standard for the prokaryotic species definition.	Michael Richter, Ramon Rosselló-Móra	Proc Natl Acad Sci U S A	2009	19855009	Yes
1667	1460	1460.0	33.62	33.6	Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone.	M B Luskin	Neuron	1993	8338665	Yes
1668	4378	1459.3	150.89	50.3	Phylogenetic identification and in situ detection of individual microbial cells without cultivation.	R I Amann, W Ludwig, K H Schleifer	Microbiol Rev	1995	7535888	No
1669	2918	1459.0	65.79	32.9	Cell migration: a physically integrated molecular process.	D A Lauffenburger, A F Horwitz	Cell	1996	8608589	No
1670	1459	1459.0	25.29	25.3	Neuronal specification in the spinal cord: inductive signals and transcriptional codes.	T M Jessell	Nat Rev Genet	2000	11262869	No
1671	4375	1458.3	84.44	28.1	Notch signaling: cell fate control and signal integration in development.	S Artavanis-Tsakonas, M D Rand, R J Lake	Science	1999	10221902	No
1672	1457	1457.0	0.0	0.0	Selforganization of matter and the evolution of biological macromolecules.	M Eigen	Naturwissenschaften	1971	4942363	No
1673	1457	1457.0	35.01	35.0	A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin.	D A Gewirtz	Biochem Pharmacol	1999	10075079	No
1674	1457	1457.0	31.62	31.6	Oxidative stress shortens telomeres.	Thomas von Zglinicki	Trends Biochem Sci	2002	12114022	Yes
1675	2914	1457.0	95.42	47.7	Alzheimer's disease.	Henry W Querfurth, Frank M LaFerla	N Engl J Med	2010	20107219	No
1676	5826	1456.5	0.0	0.0	A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples.	M A Markwell, S M Haas, L L Bieber, N E Tolbert	Anal Biochem	1978	98070	Yes
1677	1456	1456.0	0.0	0.0	Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections.	R W Sperry	Proc Natl Acad Sci U S A	1963	14077501	Yes
1678	1456	1456.0	34.76	34.8	Perceptions of epigenetics.	Adrian Bird	Nature	2007	17522671	Yes
1679	2912	1456.0	72.63	36.3	Shared principles in NF-kappaB signaling.	Matthew S Hayden, Sankar Ghosh	Cell	2008	18267068	No
1680	7279	1455.8	0.0	0.0	Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function.	S Katz, A B Ford, R W Moskowitz, B A Jackson, M W Jaffe	JAMA	1963	14044222	Yes
1681	1455	1455.0	31.39	31.4	Neurotrophins and their receptors: a convergence point for many signalling pathways.	Moses V Chao	Nat Rev Neurosci	2003	12671646	No
1682	2908	1454.0	68.37	34.2	Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.	C Auffray, F Rougeon	Eur J Biochem	1980	6772444	Yes
1683	1454	1454.0	40.75	40.8	Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms.	J A Beavo	Physiol Rev	1995	7480160	No
1684	2908	1454.0	97.86	48.9	Molecular mechanisms and clinical applications of angiogenesis.	Peter Carmeliet, Rakesh K Jain	Nature	2011	21593862	No
1685	4361	1453.7	118.69	39.6	A neural substrate of prediction and reward.	W Schultz, P Dayan, P R Montague	Science	1997	9054347	No
1686	1453	1453.0	29.0	29.0	Intrinsically unstructured proteins.	Peter Tompa	Trends Biochem Sci	2002	12368089	No
1687	1452	1452.0	39.44	39.4	Redox signaling: nitrosylation and related target interactions of nitric oxide.	J S Stamler	Cell	1994	7923362	No
1688	1452	1452.0	35.77	35.8	Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study).	K M Fox	Lancet	2003	13678872	Yes
1689	1452	1452.0	0.0	0.0	Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes.	P C Nowell	Cancer Res	1960	14427849	Yes
1690	1452	1452.0	0.0	0.0	Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues.	I E Bush	Biochem J	1952	14915960	Yes
1691	4354	1451.3	0.0	0.0	Hydroperoxide metabolism in mammalian organs.	B Chance, H Sies, A Boveris	Physiol Rev	1979	37532	Yes
1692	1451	1451.0	0.0	0.0	The mechanism of muscular contraction.	H E Huxley	Science	1969	4181952	No
1693	1450	1450.0	0.0	0.0	Defective repair replication of DNA in xeroderma pigmentosum.	J E Cleaver	Nature	1968	5655953	Yes
1694	2900	1450.0	66.95	33.5	Complex networks orchestrate epithelial-mesenchymal transitions.	Jean Paul Thiery, Jonathan P Sleeman	Nat Rev Mol Cell Biol	2006	16493418	No
1695	2899	1449.5	83.62	41.8	Diarrheagenic Escherichia coli.	J P Nataro, J B Kaper	Clin Microbiol Rev	1998	9457432	No
1696	2898	1449.0	0.0	0.0	Diabetes and cardiovascular disease. The Framingham study.	W B Kannel, D L McGee	JAMA	1979	430798	Yes
1697	1449	1449.0	0.0	0.0	Ionic blockage of sodium channels in nerve.	A M Woodhull	J Gen Physiol	1973	4541078	Yes
1698	1449	1449.0	0.0	0.0	The organization of proteins in the human red blood cell membrane. A review.	T L Steck	J Cell Biol	1974	4600883	No
1699	1449	1449.0	0.0	0.0	Starch gel electrophoresis in a discontinous system of buffers.	M D Poulik	Nature	1957	13493570	Yes
1700	1449	1449.0	0.0	0.0	Impulses and Physiological States in Theoretical Models of Nerve Membrane.	R Fitzhugh	Biophys J	1961	19431309	Yes
1701	8692	1448.7	287.16	47.9	Cancer statistics, 2009.	Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J Thun	CA Cancer J Clin	2009	19474385	Yes
1702	1448	1448.0	32.07	32.1	From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.	W A Catterall	Neuron	2000	10798388	No
1703	2896	1448.0	0.0	0.0	Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses.	D H Clarke, J Casals	Am J Trop Med Hyg	1958	13571577	Yes
1704	1447	1447.0	31.6	31.6	Drug discovery: a historical perspective.	J Drews	Science	2000	10720314	No
1705	1447	1447.0	0.0	0.0	The free amino groups of insulin.	F Sanger	Biochem J	1945	16747948	Yes
1706	1445	1445.0	43.02	43.0	Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications.	M D Maines	FASEB J	1988	3290025	No
1707	2890	1445.0	76.79	38.4	The expanding universe of T-cell subsets: Th1, Th2 and more.	T R Mosmann, S Sad	Immunol Today	1996	8820272	No
1708	1445	1445.0	42.1	42.1	Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat.	P A Bradford	Clin Microbiol Rev	2001	11585791	No
1709	2890	1445.0	105.5	52.8	Palladium-catalyzed ligand-directed C-H functionalization reactions.	Thomas W Lyons, Melanie S Sanford	Chem Rev	2010	20078038	No
1710	5778	1444.5	0.0	0.0	The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes.	L A Sternberger, P H Hardy, J J Cuculis, H G Meyer	J Histochem Cytochem	1970	4192899	Yes
1711	1444	1444.0	46.19	46.2	Evidence for a central component of post-injury pain hypersensitivity.	C J Woolf	Nature	1983	6656869	Yes
1712	1443	1443.0	48.5	48.5	Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC.	G A McPherson	J Pharmacol Methods	1985	3840547	Yes
1713	1443	1443.0	37.7	37.7	Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia.	Shitij Kapur	Am J Psychiatry	2003	12505794	No
1714	2885	1442.5	80.12	40.1	A rapid boiling method for the preparation of bacterial plasmids.	D S Holmes, M Quigley	Anal Biochem	1981	6269464	Yes
1715	1442	1442.0	0.0	0.0	Stimulated acoustic emissions from within the human auditory system.	D T Kemp	J Acoust Soc Am	1978	744838	Yes
1716	1442	1442.0	28.94	28.9	Protein kinases--the major drug targets of the twenty-first century?	Philip Cohen	Nat Rev Drug Discov	2002	12120282	No
1717	1442	1442.0	0.0	0.0	Nutrition needs of mammalian cells in tissue culture.	H Eagle	Science	1955	13255879	Yes
1718	1442	1442.0	29.01	29.0	Protein degradation and protection against misfolded or damaged proteins.	Alfred L Goldberg	Nature	2003	14685250	No
1719	1441	1441.0	0.0	0.0	Superoxide dismutases.	I Fridovich	Annu Rev Biochem	1975	1094908	No
1720	4323	1441.0	121.24	40.4	Dating of the human-ape splitting by a molecular clock of mitochondrial DNA.	M Hasegawa, H Kishino, T Yano	J Mol Evol	1985	3934395	Yes
1721	2880	1440.0	112.41	56.2	The mini-mental state examination: a comprehensive review.	T N Tombaugh, N J McIntyre	J Am Geriatr Soc	1992	1512391	No
1722	4320	1440.0	113.06	37.7	The rapid generation of mutation data matrices from protein sequences.	D T Jones, W R Taylor, J M Thornton	Comput Appl Biosci	1992	1633570	Yes
1723	2879	1439.5	0.0	0.0	3' non-coding region sequences in eukaryotic messenger RNA.	N J Proudfoot, G G Brownlee	Nature	1976	822353	Yes
1724	2879	1439.5	106.52	53.3	The transtheoretical model of health behavior change.	J O Prochaska, W F Velicer	Am J Health Promot	1997	10170434	No
1725	2878	1439.0	59.64	29.8	NF-kappaB regulation in the immune system.	Qiutang Li, Inder M Verma	Nat Rev Immunol	2002	12360211	No
1726	2877	1438.5	0.0	0.0	Mutants of Escherichia coli requiring methionine or vitamin B12.	B D Davis, E S Mingioli	J Bacteriol	1950	15436457	Yes
1727	14378	1437.8	358.02	35.8	Multilineage potential of adult human mesenchymal stem cells.	M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R Marshak	Science	1999	10102814	Yes
1728	5749	1437.2	234.95	58.7	16S ribosomal DNA amplification for phylogenetic study.	W G Weisburg, S M Barns, D A Pelletier, D J Lane	J Bacteriol	1991	1987160	Yes
1729	1437	1437.0	74.43	74.4	Statistics corner: A guide to appropriate use of correlation coefficient in medical research.	M M Mukaka	Malawi Med J	2012	23638278	Yes
1730	2873	1436.5	0.0	0.0	Assay of proteins in the presence of interfering materials.	A Bensadoun, D Weinstein	Anal Biochem	1976	1259145	Yes
1731	1436	1436.0	0.0	0.0	Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle.	H E Huxley	J Mol Biol	1963	14064165	Yes
1732	1435	1435.0	37.1	37.1	Type I diabetes mellitus. A chronic autoimmune disease.	G S Eisenbarth	N Engl J Med	1986	3517648	No
1733	2869	1434.5	55.82	27.9	The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.	Michael H Glickman, Aaron Ciechanover	Physiol Rev	2002	11917093	No
1734	1434	1434.0	37.62	37.6	Capacitative calcium entry revisited.	J W Putney	Cell Calcium	1990	1965707	No
1735	1434	1434.0	34.16	34.2	Binary Agrobacterium vectors for plant transformation.	M Bevan	Nucleic Acids Res	1984	6095209	Yes
1736	2866	1433.0	75.01	37.5	Empirical threshold values for quantitative trait mapping.	G A Churchill, R W Doerge	Genetics	1994	7851788	Yes
1737	2861	1430.5	60.97	30.5	Toll-like receptor control of the adaptive immune responses.	Akiko Iwasaki, Ruslan Medzhitov	Nat Immunol	2004	15454922	No
1738	12872	1430.2	402.78	44.8	The 1982 revised criteria for the classification of systemic lupus erythematosus.	E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J Winchester	Arthritis Rheum	1982	7138600	Yes
1739	1430	1430.0	32.55	32.5	An approximately unbiased test of phylogenetic tree selection.	Hidetoshi Shimodaira	Syst Biol	2002	12079646	Yes
1740	1430	1430.0	29.49	29.5	Immunosuppressive networks in the tumour environment and their therapeutic relevance.	Weiping Zou	Nat Rev Cancer	2005	15776005	No
1741	2859	1429.5	57.17	28.6	Missing pieces in the NF-kappaB puzzle.	Sankar Ghosh, Michael Karin	Cell	2002	11983155	No
1742	1429	1429.0	0.0	0.0	Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate.	J W Olney	Science	1969	5778021	Yes
1743	2857	1428.5	72.67	36.3	Adipose tissue as an endocrine organ.	Erin E Kershaw, Jeffrey S Flier	J Clin Endocrinol Metab	2004	15181022	No
1744	5713	1428.2	118.79	29.7	A comparison of normalization methods for high density oligonucleotide array data based on variance and bias.	B M Bolstad, R A Irizarry, M Astrand, T P Speed	Bioinformatics	2003	12538238	Yes
1745	1428	1428.0	0.0	0.0	The Gingival Index, the Plaque Index and the Retention Index Systems.	H Löe	J Periodontol	1967	5237684	Yes
1746	1428	1428.0	51.88	51.9	Dual-task interference in simple tasks: data and theory.	H Pashler	Psychol Bull	1994	7972591	No
1747	1427	1427.0	25.88	25.9	Histone acetylation and transcriptional regulatory mechanisms.	K Struhl	Genes Dev	1998	9499396	No
1748	1427	1427.0	35.5	35.5	In vivo near-infrared fluorescence imaging.	John V Frangioni	Curr Opin Chem Biol	2003	14580568	No
1749	2853	1426.5	76.01	38.0	Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation.	M A Nitsche, W Paulus	J Physiol	2000	10990547	Yes
1750	1426	1426.0	33.96	34.0	Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis.	S C Manolagas	Endocr Rev	2000	10782361	No
1751	2851	1425.5	82.89	41.4	Dali server: conservation mapping in 3D.	Liisa Holm, Päivi Rosenström	Nucleic Acids Res	2010	20457744	Yes
1752	1425	1425.0	0.0	0.0	A clinical method for assessing the ventilatory response to carbon dioxide.	D J Read	Australas Ann Med	1967	6032026	Yes
1753	1425	1425.0	45.52	45.5	Polycystic ovary syndrome.	S Franks	N Engl J Med	1995	7651477	No
1754	2850	1425.0	55.64	27.8	Cellular motility driven by assembly and disassembly of actin filaments.	Thomas D Pollard, Gary G Borisy	Cell	2003	12600310	No
1755	1424	1424.0	33.76	33.8	PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms.	Michael F. Thomashow	Annu Rev Plant Physiol Plant Mol Biol	1999	15012220	Yes
1756	1423	1423.0	0.0	0.0	Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis.	M P Blaustein	Am J Physiol	1977	324293	No
1757	1423	1423.0	33.7	33.7	Developmental cell death: morphological diversity and multiple mechanisms.	P G Clarke	Anat Embryol (Berl)	1990	2186664	No
1758	2846	1423.0	69.39	34.7	The incidence of congenital heart disease.	Julien I E Hoffman, Samuel Kaplan	J Am Coll Cardiol	2002	12084585	No
1759	4266	1422.0	106.76	35.6	Two-photon laser scanning fluorescence microscopy.	W Denk, J H Strickler, W W Webb	Science	1990	2321027	Yes
1760	1422	1422.0	0.0	0.0	A modified ninhydrin colorimetric analysis for amino acids.	H Rosen	Arch Biochem Biophys	1957	13412116	Yes
1761	1421	1421.0	33.71	33.7	Pathogenesis of group A streptococcal infections.	M W Cunningham	Clin Microbiol Rev	2000	10885988	No
1762	2841	1420.5	82.03	41.0	Multiple sclerosis.	Alastair Compston, Alasdair Coles	Lancet	2008	18970977	Yes
1763	1420	1420.0	78.13	78.1	Subjective well-being.	E Diener	Psychol Bull	1984	6399758	No
1764	2840	1420.0	54.21	27.1	Mutations affecting segment number and polarity in Drosophila.	C Nüsslein-Volhard, E Wieschaus	Nature	1980	6776413	Yes
1765	2840	1420.0	84.94	42.5	The precuneus: a review of its functional anatomy and behavioural correlates.	Andrea E Cavanna, Michael R Trimble	Brain	2006	16399806	No
1766	2839	1419.5	62.65	31.3	Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions.	E Krissinel, K Henrick	Acta Crystallogr D Biol Crystallogr	2004	15572779	Yes
1767	2838	1419.0	68.02	34.0	The human plasma proteome: history, character, and diagnostic prospects.	N Leigh Anderson, Norman G Anderson	Mol Cell Proteomics	2002	12488461	No
1768	5673	1418.2	128.93	32.2	MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform.	Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi Miyata	Nucleic Acids Res	2002	12136088	Yes
1769	1418	1418.0	0.0	0.0	Amino acid difference formula to help explain protein evolution.	R Grantham	Science	1974	4843792	Yes
1770	1418	1418.0	46.06	46.1	The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate.	G R Buettner	Arch Biochem Biophys	1993	8434935	No
1771	1418	1418.0	30.33	30.3	Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy.	R K Jain	Nat Med	2001	11533692	No
1772	2836	1418.0	60.06	30.0	The Bcl2 family: regulators of the cellular life-or-death switch.	Suzanne Cory, Jerry M Adams	Nat Rev Cancer	2002	12209154	No
1773	4251	1417.0	0.0	0.0	Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs.	C A Winter, E A Risley, G W Nuss	Proc Soc Exp Biol Med	1962	14001233	Yes
1774	2833	1416.5	61.9	30.9	The Ki-67 protein: from the known and the unknown.	T Scholzen, J Gerdes	J Cell Physiol	2000	10653597	No
1775	1416	1416.0	35.3	35.3	General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.	R A Houghten	Proc Natl Acad Sci U S A	1985	2410914	Yes
1776	1416	1416.0	36.7	36.7	The biology of incretin hormones.	Daniel J Drucker	Cell Metab	2006	16517403	No
1777	1416	1416.0	51.81	51.8	Cognitive reserve.	Yaakov Stern	Neuropsychologia	2009	19467352	No
1778	2830	1415.0	59.46	29.7	Chemokines: a new classification system and their role in immunity.	A Zlotnik, O Yoshie	Immunity	2000	10714678	No
1779	1415	1415.0	32.95	33.0	Mechanisms of bone metastasis.	G David Roodman	N Engl J Med	2004	15084698	No
1780	1415	1415.0	30.24	30.2	Regulatory T cells, tumour immunity and immunotherapy.	Weiping Zou	Nat Rev Immunol	2006	16557261	No
1781	1413	1413.0	32.62	32.6	The cadherins: cell-cell adhesion molecules controlling animal morphogenesis.	M Takeichi	Development	1988	3048970	No
1782	1413	1413.0	34.01	34.0	PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.	B M Spiegelman	Diabetes	1998	9568680	No
1783	1413	1413.0	27.23	27.2	Aggresomes, inclusion bodies and protein aggregation.	R R Kopito	Trends Cell Biol	2000	11121744	No
1784	1413	1413.0	0.0	0.0	Modality and topographic properties of single neurons of cat's somatic sensory cortex.	V B Mountcastle	J Neurophysiol	1957	13439410	Yes
1785	5648	1412.0	144.67	36.2	Improved optimization for the robust and accurate linear registration and motion correction of brain images.	Mark Jenkinson, Peter Bannister, Michael Brady, Stephen Smith	Neuroimage	2002	12377157	Yes
1786	1412	1412.0	0.0	0.0	Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions.	W C Schneider	J Biol Chem	1948	18886166	Yes
1787	1412	1412.0	61.55	61.5	Antibiotics in the aquatic environment--a review--part I.	Klaus Kümmerer	Chemosphere	2009	19185900	No
1788	1412	1412.0	56.12	56.1	Large-scale brain networks and psychopathology: a unifying triple network model.	Vinod Menon	Trends Cogn Sci	2011	21908230	No
1789	1411	1411.0	39.63	39.6	Pathogen recognition and inflammatory signaling in innate immune defenses.	Trine H Mogensen	Clin Microbiol Rev	2009	19366914	No
1790	2821	1410.5	0.0	0.0	Microdetermination of long-chain fatty acids in plasma and tissues.	V P Dole, H Meinertz	J Biol Chem	1960	13817286	Yes
1791	2820	1410.0	63.81	31.9	Raster3D Version 2.0. A program for photorealistic molecular graphics.	E A Merritt, M E Murphy	Acta Crystallogr D Biol Crystallogr	1994	15299354	Yes
1792	1409	1409.0	28.7	28.7	Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing.	D I Svergun	Biophys J	1999	10354416	Yes
1793	1409	1409.0	36.16	36.2	Insulin and insulin-like growth factor signalling in neoplasia.	Michael Pollak	Nat Rev Cancer	2008	19029956	No
1794	1409	1409.0	57.02	57.0	Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement.	Virginia A Moyer	Ann Intern Med	2012	22801674	No
1795	1408	1408.0	59.25	59.2	Responses to depression and their effects on the duration of depressive episodes.	S Nolen-Hoeksema	J Abnorm Psychol	1991	1757671	No
1796	1408	1408.0	52.07	52.1	The case-crossover design: a method for studying transient effects on the risk of acute events.	M Maclure	Am J Epidemiol	1991	1985444	Yes
1797	1408	1408.0	0.0	0.0	The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases.	O V Batson	Ann Surg	1940	17857618	Yes
1798	2811	1405.5	66.02	33.0	A novel multigene family may encode odorant receptors: a molecular basis for odor recognition.	L Buck, R Axel	Cell	1991	1840504	Yes
1799	2808	1404.0	66.53	33.3	The MAPK signaling cascade.	R Seger, E G Krebs	FASEB J	1995	7601337	No
1800	2807	1403.5	84.11	42.1	An information-maximization approach to blind separation and blind deconvolution.	A J Bell, T J Sejnowski	Neural Comput	1995	7584893	Yes
1801	5613	1403.2	244.86	61.2	An inventory for measuring clinical anxiety: psychometric properties.	A T Beck, N Epstein, G Brown, R A Steer	J Consult Clin Psychol	1988	3204199	Yes
1802	1403	1403.0	34.58	34.6	Neurovascular regulation in the normal brain and in Alzheimer's disease.	Costantino Iadecola	Nat Rev Neurosci	2004	15100718	No
1803	1403	1403.0	51.13	51.1	Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders.	Berislav V Zlokovic	Nat Rev Neurosci	2011	22048062	No
1804	1401	1401.0	44.07	44.1	Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance.	L Bravo	Nutr Rev	1998	9838798	No
1805	2802	1401.0	65.24	32.6	How matrix metalloproteinases regulate cell behavior.	M D Sternlicht, Z Werb	Annu Rev Cell Dev Biol	2001	11687497	No
1806	5600	1400.0	165.75	41.4	Functional connectivity in the motor cortex of resting human brain using echo-planar MRI.	B Biswal, F Z Yetkin, V M Haughton, J S Hyde	Magn Reson Med	1995	8524021	Yes
1807	7000	1400.0	147.89	29.6	Prospective identification of tumorigenic breast cancer cells.	Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F Clarke	Proc Natl Acad Sci U S A	2003	12629218	Yes
1808	2799	1399.5	86.54	43.3	Unified approach for molecular dynamics and density-functional theory.	Car, Parrinello	Phys Rev Lett	1985	10032153	Yes
1809	1399	1399.0	65.48	65.5	The structure and properties of the sense of coherence scale.	A Antonovsky	Soc Sci Med	1993	8480217	Yes
1810	5593	1398.2	0.0	0.0	A rating scale for mania: reliability, validity and sensitivity.	R C Young, J T Biggs, V E Ziegler, D A Meyer	Br J Psychiatry	1978	728692	Yes
1811	1398	1398.0	0.0	0.0	R factor transfer in Rhizobium leguminosarum.	J E Beringer	J Gen Microbiol	1974	4612098	Yes
1812	1398	1398.0	47.0	47.0	Validation of a decisional conflict scale.	A M O'Connor	Med Decis Making	1995	7898294	Yes
1813	4194	1398.0	92.93	31.0	NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.	S Ghosh, M J May, E B Kopp	Annu Rev Immunol	1998	9597130	No
1814	1398	1398.0	36.56	36.6	Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology.	B Winkel-Shirley	Plant Physiol	2001	11402179	No
1815	2796	1398.0	0.0	0.0	Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.	H J Bloom, W W Richardson	Br J Cancer	1957	13499785	Yes
1816	1397	1397.0	50.07	50.1	Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances.	Joseph J Volpe	Lancet Neurol	2009	19081519	No
1817	2792	1396.0	85.51	42.8	The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.	J D Hayes, D J Pulford	Crit Rev Biochem Mol Biol	1995	8770536	No
1818	1396	1396.0	0.0	0.0	Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look.	J Wyman	Adv Protein Chem	1964	14268785	No
1819	2790	1395.0	0.0	0.0	Empirical predictions of protein conformation.	P Y Chou, G D Fasman	Annu Rev Biochem	1978	354496	No
1820	1394	1394.0	52.06	52.1	Falls in older people: epidemiology, risk factors and strategies for prevention.	Laurence Z Rubenstein	Age Ageing	2006	16926202	No
1821	2784	1392.0	73.08	36.5	Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators.	I Issemann, S Green	Nature	1990	2129546	Yes
1822	2784	1392.0	85.87	42.9	Intracellular pH.	A Roos, W F Boron	Physiol Rev	1981	7012859	No
1823	1391	1391.0	0.0	0.0	Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.	K S McCully	Am J Pathol	1969	5792556	Yes
1824	1391	1391.0	34.64	34.6	The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting.	H Maeda	Adv Enzyme Regul	2001	11384745	No
1825	2780	1390.0	0.0	0.0	Brain stem reticular formation and activation of the EEG.	G Moruzzi, H W Magoun	Electroencephalogr Clin Neurophysiol	1949	18421835	Yes
1826	6946	1389.2	151.21	30.2	Site-directed mutagenesis by overlap extension using the polymerase chain reaction.	S N Ho, H D Hunt, R M Horton, J K Pullen, L R Pease	Gene	1989	2744487	Yes
1827	2775	1387.5	0.0	0.0	A method of trace iodination of proteins for immunologic studies.	P J McConahey, F J Dixon	Int Arch Allergy Appl Immunol	1966	4160044	Yes
1828	1387	1387.0	0.0	0.0	The genetical evolution of social behaviour. II.	W D Hamilton	J Theor Biol	1964	5875340	Yes
1829	2772	1386.0	71.92	36.0	A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.	J Messing, J Vieira	Gene	1982	6295880	Yes
1830	1386	1386.0	39.98	40.0	Isolation and cultivation of Lyme disease spirochetes.	A G Barbour	Yale J Biol Med	1984	6393604	Yes
1831	1386	1386.0	33.11	33.1	Functions of ceramide in coordinating cellular responses to stress.	Y A Hannun	Science	1996	8943189	No
1832	4156	1385.3	121.09	40.4	The fusiform face area: a module in human extrastriate cortex specialized for face perception.	N Kanwisher, J McDermott, M M Chun	J Neurosci	1997	9151747	Yes
1833	1385	1385.0	0.0	0.0	Statistical analysis of enzyme kinetic data.	W W Cleland	Methods Enzymol	1979	502857	Yes
1834	1385	1385.0	32.68	32.7	Speculations on the functions of the major heat shock and glucose-regulated proteins.	H R Pelham	Cell	1986	2944601	Yes
1835	1384	1384.0	0.0	0.0	Human cardiovascular adjustments to exercise and thermal stress.	L B Rowell	Physiol Rev	1974	4587247	No
1836	1384	1384.0	36.73	36.7	Aspergillus fumigatus and aspergillosis.	J P Latgé	Clin Microbiol Rev	1999	10194462	No
1837	1383	1383.0	0.0	0.0	The measurement of psychological androgyny.	S L Bem	J Consult Clin Psychol	1974	4823550	Yes
1838	1383	1383.0	27.36	27.4	Vienna RNA secondary structure server.	Ivo L Hofacker	Nucleic Acids Res	2003	12824340	Yes
1839	1383	1383.0	0.0	0.0	Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System.	K Fuxe	Acta Physiol Scand Suppl	1965	14319769	Yes
1840	1383	1383.0	33.23	33.2	Far-field optical nanoscopy.	Stefan W Hell	Science	2007	17525330	No
1841	2764	1382.0	0.0	0.0	A protein sequenator.	P Edman, G Begg	Eur J Biochem	1967	6059350	Yes
1842	4145	1381.7	141.85	47.3	Vascular endothelial cells synthesize nitric oxide from L-arginine.	R M Palmer, D S Ashton, S Moncada	Nature	1988	3131684	Yes
1843	2763	1381.5	0.0	0.0	A scaled version of the General Health Questionnaire.	D P Goldberg, V F Hillier	Psychol Med	1979	424481	Yes
1844	2763	1381.5	92.26	46.1	The efficiency of systematic sampling in stereology and its prediction.	H J Gundersen, E B Jensen	J Microsc	1987	3430576	Yes
1845	1381	1381.0	0.0	0.0	Selection of successive tumour lines for metastasis.	I J Fidler	Nat New Biol	1973	4512654	Yes
1846	2762	1381.0	62.39	31.2	An essential role for NF-kappaB in preventing TNF-alpha-induced cell death.	A A Beg, D Baltimore	Science	1996	8864118	Yes
1847	5523	1380.8	126.48	31.6	Probability-based protein identification by searching sequence databases using mass spectrometry data.	D N Perkins, D J Pappin, D M Creasy, J S Cottrell	Electrophoresis	1999	10612281	Yes
1848	1380	1380.0	0.0	0.0	Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat.	C A Barnes	J Comp Physiol Psychol	1979	221551	Yes
1849	1380	1380.0	72.67	72.7	Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control.	F E Zajac	Crit Rev Biomed Eng	1989	2676342	No
1850	2759	1379.5	59.74	29.9	Development by self-digestion: molecular mechanisms and biological functions of autophagy.	Beth Levine, Daniel J Klionsky	Dev Cell	2004	15068787	No
1851	1379	1379.0	31.07	31.1	Protein misfolding, evolution and disease.	C M Dobson	Trends Biochem Sci	1999	10470028	No
1852	2758	1379.0	100.99	50.5	Neurocircuitry of addiction.	George F Koob, Nora D Volkow	Neuropsychopharmacology	2010	19710631	No
1853	1378	1378.0	32.67	32.7	The molecular logic of endocannabinoid signalling.	Daniele Piomelli	Nat Rev Neurosci	2003	14595399	No
1854	1378	1378.0	40.9	40.9	n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases.	Philip C Calder	Am J Clin Nutr	2006	16841861	No
1855	2755	1377.5	88.77	44.4	Functional architecture of basal ganglia circuits: neural substrates of parallel processing.	G E Alexander, M D Crutcher	Trends Neurosci	1990	1695401	No
1856	4132	1377.3	109.01	36.3	Optimization by simulated annealing.	S Kirkpatrick, C D Gelatt, M P Vecchi	Science	1983	17813860	Yes
1857	2754	1377.0	67.75	33.9	Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.	F Q Schafer, G R Buettner	Free Radic Biol Med	2001	11368918	No
1858	2753	1376.5	70.62	35.3	CLUSTAL: a package for performing multiple sequence alignment on a microcomputer.	D G Higgins, P M Sharp	Gene	1988	3243435	Yes
1859	2753	1376.5	70.51	35.3	Steatohepatitis: a tale of two "hits"?	C P Day, O F James	Gastroenterology	1998	9547102	No
1860	2752	1376.0	92.0	46.0	Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics.	G R Gibson, M B Roberfroid	J Nutr	1995	7782892	No
1861	1375	1375.0	43.5	43.5	Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements.	James J P Stewart	J Mol Model	2007	17828561	Yes
1862	2749	1374.5	63.48	31.7	Microtubules as a target for anticancer drugs.	Mary Ann Jordan, Leslie Wilson	Nat Rev Cancer	2004	15057285	No
1863	1374	1374.0	0.0	0.0	An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals.	O Smithies	Biochem J	1959	13638269	Yes
1864	1374	1374.0	38.05	38.0	External validity of randomised controlled trials: "to whom do the results of this trial apply?".	Peter M Rothwell	Lancet	2005	15639683	Yes
1865	2747	1373.5	62.55	31.3	Neurotrophins: roles in neuronal development and function.	E J Huang, L F Reichardt	Annu Rev Neurosci	2001	11520916	No
1866	2746	1373.0	0.0	0.0	Prediction of protein conformation.	P Y Chou, G D Fasman	Biochemistry	1974	4358940	Yes
1867	1373	1373.0	30.18	30.2	Neurotrophins as synaptic modulators.	M M Poo	Nat Rev Neurosci	2001	11253356	No
1868	2745	1372.5	102.35	51.2	Pain assessment: global use of the Brief Pain Inventory.	C S Cleeland, K M Ryan	Ann Acad Med Singap	1994	8080219	No
1869	2745	1372.5	59.72	29.9	Coordination of circadian timing in mammals.	Steven M Reppert, David R Weaver	Nature	2002	12198538	No
1870	1372	1372.0	26.44	26.4	Ubiquitin-dependent protein degradation.	M Hochstrasser	Annu Rev Genet	1996	8982460	No
1871	1372	1372.0	32.2	32.2	The NCI60 human tumour cell line anticancer drug screen.	Robert H Shoemaker	Nat Rev Cancer	2006	16990858	No
1872	2744	1372.0	0.0	0.0	Mutations of Bacteria from Virus Sensitivity to Virus Resistance.	S E Luria, M Delbrück	Genetics	1943	17247100	Yes
1873	1372	1372.0	0.0	0.0	Note on the sampling error of the difference between correlated proportions or percentages.	Q McNEMAR	Psychometrika	1947	20254758	Yes
1874	1371	1371.0	0.0	0.0	Effects of varying the vehicle for OsO4 in tissue fixation.	J B Caulfield	J Biophys Biochem Cytol	1957	13475399	Yes
1875	12339	1371.0	461.24	51.2	STAR: ultrafast universal RNA-seq aligner.	Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R Gingeras	Bioinformatics	2013	23104886	Yes
1876	1370	1370.0	43.95	44.0	Systemic lupus erythematosus.	George C Tsokos	N Engl J Med	2011	22129255	No
1877	2739	1369.5	0.0	0.0	Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.	A J Berk, P A Sharp	Cell	1977	922889	Yes
1878	2739	1369.5	0.0	0.0	The effect of sodium ions on the electrical activity of giant axon of the squid.	A L Hodgkin, B Katz	J Physiol	1949	18128147	Yes
1879	1369	1369.0	0.0	0.0	Microbial ecology of the gastrointestinal tract.	D C Savage	Annu Rev Microbiol	1977	334036	No
1880	1369	1369.0	92.17	92.2	The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system.	F C Ewald	Clin Orthop Relat Res	1989	2805502	Yes
1881	2738	1369.0	57.85	28.9	Fitting a mixture model by expectation maximization to discover motifs in biopolymers.	T L Bailey, C Elkan	Proc Int Conf Intell Syst Mol Biol	1994	7584402	Yes
1882	1369	1369.0	57.83	57.8	Adverse health effects of high-effort/low-reward conditions.	J Siegrist	J Occup Health Psychol	1996	9547031	No
1883	2737	1368.5	75.81	37.9	Early identification of refractory epilepsy.	P Kwan, M J Brodie	N Engl J Med	2000	10660394	Yes
1884	2737	1368.5	72.37	36.2	Malignant gliomas in adults.	Patrick Y Wen, Santosh Kesari	N Engl J Med	2008	18669428	No
1885	1368	1368.0	56.69	56.7	A structured interview guide for the Hamilton Depression Rating Scale.	J B Williams	Arch Gen Psychiatry	1988	3395203	Yes
1886	1368	1368.0	31.79	31.8	Protein kinase C: structure, function, and regulation.	A C Newton	J Biol Chem	1995	7499357	No
1887	1368	1368.0	33.28	33.3	The basic science of gene therapy.	R C Mulligan	Science	1993	8493530	No
1888	1368	1368.0	29.33	29.3	Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.	S S Ferguson	Pharmacol Rev	2001	11171937	No
1889	1368	1368.0	43.54	43.5	The many roles for fluorine in medicinal chemistry.	William K Hagmann	J Med Chem	2008	18570365	Yes
1890	1367	1367.0	26.5	26.5	NK cell receptors.	L L Lanier	Annu Rev Immunol	1998	9597134	No
1891	1367	1367.0	35.17	35.2	Myeloperoxidase: friend and foe.	Seymour J Klebanoff	J Leukoc Biol	2005	15689384	No
1892	2733	1366.5	100.04	50.0	Biology of disease: free radicals and tissue injury.	B A Freeman, J D Crapo	Lab Invest	1982	6290784	No
1893	5465	1366.2	161.82	40.5	Comorbidity measures for use with administrative data.	A Elixhauser, C Steiner, D R Harris, R M Coffey	Med Care	1998	9431328	Yes
1894	1366	1366.0	45.0	45.0	Social relationships and health.	Sheldon Cohen	Am Psychol	2004	15554821	No
1895	1365	1365.0	37.03	37.0	Cell and environment interactions in tumor microregions: the multicell spheroid model.	R M Sutherland	Science	1988	2451290	Yes
1896	2730	1365.0	53.42	26.7	T-cell antigen receptor genes and T-cell recognition.	M M Davis, P J Bjorkman	Nature	1988	3043226	No
1897	1365	1365.0	35.45	35.5	Stress and hippocampal plasticity.	B S McEwen	Annu Rev Neurosci	1999	10202533	No
1898	2730	1365.0	90.17	45.1	Density functionals with broad applicability in chemistry.	Yan Zhao, Donald G Truhlar	Acc Chem Res	2008	18186612	Yes
1899	1365	1365.0	37.97	38.0	Integration, scaling, space-group assignment and post-refinement.	Wolfgang Kabsch	Acta Crystallogr D Biol Crystallogr	2010	20124693	Yes
1900	2729	1364.5	81.65	40.8	Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research.	Sally S Dickerson, Margaret E Kemeny	Psychol Bull	2004	15122924	Yes
1901	2728	1364.0	70.35	35.2	Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins.	D Marion, K Wüthrich	Biochem Biophys Res Commun	1983	6307308	Yes
1902	1364	1364.0	28.73	28.7	RNA silencing in plants.	David Baulcombe	Nature	2004	15372043	No
1903	1364	1364.0	31.53	31.5	Cancer epigenomics: DNA methylomes and histone-modification maps.	Manel Esteller	Nat Rev Genet	2007	17339880	No
1904	2725	1362.5	82.22	41.1	Glycine potentiates the NMDA response in cultured mouse brain neurons.	J W Johnson, P Ascher	Nature	1987	2433595	Yes
1905	1362	1362.0	47.87	47.9	Multiple calcium channels and neuronal function.	R J Miller	Science	1987	2432656	No
1906	1362	1362.0	0.0	0.0	Codon--anticodon pairing: the wobble hypothesis.	F H Crick	J Mol Biol	1966	5969078	Yes
1907	1362	1362.0	64.26	64.3	The emerging role of lncRNAs in cancer.	Maite Huarte	Nat Med	2015	26540387	No
1908	1362	1362.0	66.98	67.0	Gctf: Real-time CTF determination and correction.	Kai Zhang	J Struct Biol	2016	26592709	Yes
1909	2723	1361.5	84.15	42.1	Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI.	P J Basser, C Pierpaoli	J Magn Reson B	1996	8661285	Yes
1910	2722	1361.0	76.27	38.1	Transforming growth factor beta in tissue fibrosis.	W A Border, N A Noble	N Engl J Med	1994	7935686	No
1911	1361	1361.0	38.76	38.8	A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology.	J Engel	Epilepsia	2001	11422340	Yes
1912	1361	1361.0	37.83	37.8	Task switching.	Stephen Monsell	Trends Cogn Sci	2003	12639695	Yes
1913	2722	1361.0	0.0	0.0	Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons.	A Dahlstroem, K Fuxe	Acta Physiol Scand Suppl	1964	14229500	Yes
1914	2720	1360.0	90.08	45.0	Unidentified curved bacilli on gastric epithelium in active chronic gastritis.	J R Warren, B Marshall	Lancet	1983	6134060	Yes
1915	1360	1360.0	39.95	40.0	Leishmaniasis: current situation and new perspectives.	P Desjeux	Comp Immunol Microbiol Infect Dis	2004	15225981	No
1916	1360	1360.0	0.0	0.0	Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples.	P F Scholander	J Biol Chem	1947	20281644	Yes
1917	2719	1359.5	0.0	0.0	Immunoassay of endogenous plasma insulin in man.	R S Yalow, S A Berson	J Clin Invest	1960	13846364	Yes
1918	1359	1359.0	30.56	30.6	Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles.	M Kozak	Microbiol Rev	1983	6343825	No
1919	1359	1359.0	54.3	54.3	Cardiac valve surgery--the "French correction".	A Carpentier	J Thorac Cardiovasc Surg	1983	6887954	Yes
1920	1358	1358.0	40.62	40.6	The aging process.	D Harman	Proc Natl Acad Sci U S A	1981	6947277	Yes
1921	2716	1358.0	84.76	42.4	Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being.	James J Gross, Oliver P John	J Pers Soc Psychol	2003	12916575	Yes
1922	1358	1358.0	0.0	0.0	Potential, Impedance, And Rectification In Membranes.	D E Goldman	J Gen Physiol	1943	19873371	Yes
1923	4073	1357.7	88.95	29.7	Toll-like receptors.	Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira	Annu Rev Immunol	2003	12524386	No
1924	2715	1357.5	77.91	39.0	Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper.	B R Celli, W MacNee	Eur Respir J	2004	15219010	No
1925	9498	1356.9	212.59	30.4	Embryonic stem cell lines derived from human blastocysts.	J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M Jones	Science	1998	9804556	Yes
1926	1356	1356.0	0.0	0.0	Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein.	T Spector	Anal Biochem	1978	655375	Yes
1927	1356	1356.0	0.0	0.0	Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion.	S S Lehrer	Biochemistry	1971	5119250	Yes
1928	1356	1356.0	31.51	31.5	Tumor metastasis: mechanistic insights and clinical challenges.	Patricia S Steeg	Nat Med	2006	16892035	No
1929	1356	1356.0	34.42	34.4	Five rules for the evolution of cooperation.	Martin A Nowak	Science	2006	17158317	No
1930	2710	1355.0	168.72	84.4	Rating systems in the evaluation of knee ligament injuries.	Y Tegner, J Lysholm	Clin Orthop Relat Res	1985	4028566	Yes
1931	2710	1355.0	0.0	0.0	The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat.	J O'Keefe, J Dostrovsky	Brain Res	1971	5124915	Yes
1932	1355	1355.0	44.28	44.3	Efficient analysis of experimental observations.	W J Dixon	Annu Rev Pharmacol Toxicol	1980	7387124	Yes
1933	4062	1354.0	0.0	0.0	Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins.	J Garnier, D J Osguthorpe, B Robson	J Mol Biol	1978	642007	Yes
1934	2708	1354.0	0.0	0.0	Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation.	R L Heath, L Packer	Arch Biochem Biophys	1968	5655425	Yes
1935	1354	1354.0	34.92	34.9	An economic method for the fluorescent labeling of PCR fragments.	M Schuelke	Nat Biotechnol	2000	10657137	Yes
1936	1354	1354.0	0.0	0.0	Cerebral vascular accidents in patients over the age of 60. II. Prognosis.	J Rankin	Scott Med J	1957	13432835	Yes
1937	2707	1353.5	109.43	54.7	Assessment of eating disorders: interview or self-report questionnaire?	C G Fairburn, S J Beglin	Int J Eat Disord	1994	7866415	Yes
1938	2706	1353.0	85.92	43.0	Performing the exact test of Hardy-Weinberg proportion for multiple alleles.	S W Guo, E A Thompson	Biometrics	1992	1637966	Yes
1939	2706	1353.0	102.47	51.2	The need to belong: desire for interpersonal attachments as a fundamental human motivation.	R F Baumeister, M R Leary	Psychol Bull	1995	7777651	No
1940	2706	1353.0	63.73	31.9	Lipopolysaccharide endotoxins.	Christian R H Raetz, Chris Whitfield	Annu Rev Biochem	2002	12045108	No
1941	1353	1353.0	42.64	42.6	Surface plasmon resonance sensors for detection of chemical and biological species.	Jirí Homola	Chem Rev	2008	18229953	No
1942	1352	1352.0	45.33	45.3	Interleukin-1.	C A Dinarello	Rev Infect Dis	1984	6369481	No
1943	1352	1352.0	32.15	32.1	Ordered porous materials for emerging applications.	Mark E Davis	Nature	2002	12075343	No
1944	4053	1351.0	90.62	30.2	Telomeres shorten during ageing of human fibroblasts.	C B Harley, A B Futcher, C W Greider	Nature	1990	2342578	Yes
1945	1351	1351.0	62.78	62.8	Pro-resolving lipid mediators are leads for resolution physiology.	Charles N Serhan	Nature	2014	24899309	No
1946	5403	1350.8	165.68	41.4	The validity of the Hospital Anxiety and Depression Scale. An updated literature review.	Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag Neckelmann	J Psychosom Res	2002	11832252	No
1947	2701	1350.5	67.7	33.9	Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.	E S Lander, D Botstein	Genetics	1989	2563713	Yes
1948	2701	1350.5	80.9	40.5	EQ-5D: a measure of health status from the EuroQol Group.	R Rabin, F de Charro	Ann Med	2001	11491192	No
1949	2699	1349.5	87.14	43.6	Mechanisms of salinity tolerance.	Rana Munns, Mark Tester	Annu Rev Plant Biol	2008	18444910	No
1950	1349	1349.0	33.35	33.4	Neuronal synchrony: a versatile code for the definition of relations?	W Singer	Neuron	1999	10677026	No
1951	2697	1348.5	54.2	27.1	The evolutionary fate and consequences of duplicate genes.	M Lynch, J S Conery	Science	2000	11073452	No
1952	2697	1348.5	72.81	36.4	Obesity.	David W Haslam, W Philip T James	Lancet	2005	16198769	No
1953	4043	1347.7	0.0	0.0	Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation.	D D Sabatini, K Bensch, R J Barrnett	J Cell Biol	1963	13975866	Yes
1954	2694	1347.0	0.0	0.0	The respiratory chain and oxidative phosphorylation.	B Chance, G R Williams	Adv Enzymol Relat Subj Biochem	1956	13313307	Yes
1955	2694	1347.0	62.66	31.3	Cancer metastasis: building a framework.	Gaorav P Gupta, Joan Massagué	Cell	2006	17110329	No
1956	5384	1346.0	0.0	0.0	Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.	D W Cleveland, S G Fischer, M W Kirschner, U K Laemmli	J Biol Chem	1977	320200	Yes
1957	2692	1346.0	62.68	31.3	NF-kappaB: a key role in inflammatory diseases.	P P Tak, G S Firestein	J Clin Invest	2001	11134171	No
1958	1346	1346.0	74.61	74.6	The biology and function of fibroblasts in cancer.	Raghu Kalluri	Nat Rev Cancer	2016	27550820	No
1959	4037	1345.7	96.65	32.2	Click Chemistry: Diverse Chemical Function from a Few Good Reactions.	Hartmuth C. Kolb, M. G. Finn, K. Barry Sharpless	Angew Chem Int Ed Engl	2001	11433435	Yes
1960	1345	1345.0	43.81	43.8	Glutathione metabolism and its selective modification.	A Meister	J Biol Chem	1988	3053703	No
1961	1345	1345.0	0.0	0.0	Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.	J R David	Proc Natl Acad Sci U S A	1966	5229858	Yes
1962	1345	1345.0	39.71	39.7	Glycobiology: Toward Understanding the Function of Sugars.	Raymond A. Dwek	Chem Rev	1996	11848770	Yes
1963	1344	1344.0	36.36	36.4	Use and misuse of the receiver operating characteristic curve in risk prediction.	Nancy R Cook	Circulation	2007	17309939	Yes
1964	2687	1343.5	66.26	33.1	Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress.	H Cai, D G Harrison	Circ Res	2000	11073878	No
1965	1343	1343.0	0.0	0.0	A modified procedure for lead staining of thin sections.	G Millonig	J Biophys Biochem Cytol	1961	14474176	Yes
1966	1342	1342.0	35.14	35.1	The failing heart--an engine out of fuel.	Stefan Neubauer	N Engl J Med	2007	17360992	No
1967	2682	1341.0	0.0	0.0	Further improvements in the plaque technique for detecting single antibody-forming cells.	A J Cunningham, A Szenberg	Immunology	1968	5653817	Yes
1968	2682	1341.0	106.91	53.5	Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants.	Sarvajeet Singh Gill, Narendra Tuteja	Plant Physiol Biochem	2010	20870416	No
1969	2681	1340.5	55.57	27.8	Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.	P J Southern, P Berg	J Mol Appl Genet	1982	6286831	Yes
1970	1340	1340.0	43.88	43.9	Equipoise and the ethics of clinical research.	B Freedman	N Engl J Med	1987	3600702	Yes
1971	1340	1340.0	0.0	0.0	Blood gas calculator.	J W Severinghaus	J Appl Physiol	1966	5912737	Yes
1972	4020	1340.0	141.9	47.3	Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions.	Aleksandr V Marenich, Christopher J Cramer, Donald G Truhlar	J Phys Chem B	2009	19366259	Yes
1973	4019	1339.7	91.21	30.4	TOR signaling in growth and metabolism.	Stephan Wullschleger, Robbie Loewith, Michael N Hall	Cell	2006	16469695	No
1974	2678	1339.0	0.0	0.0	Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes.	E Engvall, P Perlmann	J Immunol	1972	4113792	Yes
1975	1339	1339.0	36.47	36.5	A more meaningful scoring system for determining the severity of coronary heart disease.	G G Gensini	Am J Cardiol	1983	6823874	Yes
1976	1339	1339.0	48.45	48.5	Colorimetric determination of phospholipids with ammonium ferrothiocyanate.	J C Stewart	Anal Biochem	1980	6892980	Yes
1977	1339	1339.0	41.25	41.2	Semiempirical hybrid density functional with perturbative second-order correlation.	Stefan Grimme	J Chem Phys	2006	16438568	Yes
1978	2677	1338.5	111.75	55.9	Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use.	A Y Finlay, G K Khan	Clin Exp Dermatol	1994	8033378	Yes
1979	2676	1338.0	0.0	0.0	Synchronization of Plasmodium falciparum erythrocytic stages in culture.	C Lambros, J P Vanderberg	J Parasitol	1979	383936	Yes
1980	1338	1338.0	34.63	34.6	Lead- and drug-like compounds: the rule-of-five revolution.	Christopher A Lipinski	Drug Discov Today Technol	2004	24981612	Yes
1981	1337	1337.0	27.69	27.7	Macromolecular crowding: obvious but underappreciated.	R J Ellis	Trends Biochem Sci	2001	11590012	No
1982	1337	1337.0	0.0	0.0	A simple ultraviolet spectrophotometric method for the determination of protein.	W J Waddell	J Lab Clin Med	1956	13346201	Yes
1983	1337	1337.0	29.04	29.0	The Buccaneer software for automated model building. 1. Tracing protein chains.	Kevin Cowtan	Acta Crystallogr D Biol Crystallogr	2006	16929101	Yes
1984	2672	1336.0	78.03	39.0	Mortality by cause for eight regions of the world: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9142060	Yes
1985	2671	1335.5	63.1	31.6	NF-kappa B: ten years after.	P A Baeuerle, D Baltimore	Cell	1996	8858144	No
1986	2670	1335.0	0.0	0.0	Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease.	G J Miller, N E Miller	Lancet	1975	46338	Yes
1987	1335	1335.0	32.81	32.8	Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule.	G von Heijne	J Mol Biol	1992	1593632	Yes
1988	1334	1334.0	0.0	0.0	Immunological function of the thymus.	J F Miller	Lancet	1961	14474038	Yes
1989	1334	1334.0	31.43	31.4	Hematopoietic stem-cell transplantation.	Edward A Copelan	N Engl J Med	2006	16641398	No
1990	7999	1333.2	274.99	45.8	New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0.	Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier Gascuel	Syst Biol	2010	20525638	Yes
1991	2665	1332.5	96.45	48.2	The Oswestry Disability Index.	J C Fairbank, P B Pynsent	Spine (Phila Pa 1976)	2000	11074683	No
1992	2663	1331.5	0.0	0.0	Selective loss of central cholinergic neurons in Alzheimer's disease.	P Davies, A J Maloney	Lancet	1976	63862	Yes
1993	2663	1331.5	77.17	38.6	Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis.	F D Lublin, S C Reingold	Neurology	1996	8780061	Yes
1994	1331	1331.0	34.29	34.3	Thioredoxin and glutaredoxin systems.	A Holmgren	J Biol Chem	1989	2668278	No
1995	2662	1331.0	67.43	33.7	Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule.	M D Pierschbacher, E Ruoslahti	Nature	1984	6325925	Yes
1996	3992	1330.7	100.76	33.6	Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets.	Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck Ørntoft	Cancer Res	2004	15289330	Yes
1997	1330	1330.0	45.25	45.2	Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology.	N Krieger	Am J Public Health	1992	1566949	Yes
1998	1329	1329.0	41.53	41.5	Neurotransmitters and neuromodulators in the basal ganglia.	A M Graybiel	Trends Neurosci	1990	1695398	No
1999	1329	1329.0	41.93	41.9	Domino Reactions in Organic Synthesis.	Lutz F. Tietze	Chem Rev	1996	11848746	Yes
2000	1329	1329.0	33.09	33.1	Oxidative stress in Parkinson's disease.	Peter Jenner	Ann Neurol	2003	12666096	No
2001	2656	1328.0	0.0	0.0	Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G.	E Engvall, P Perlmann	Immunochemistry	1971	5135623	Yes
2002	2655	1327.5	0.0	0.0	Peptidoglycan types of bacterial cell walls and their taxonomic implications.	K H Schleifer, O Kandler	Bacteriol Rev	1972	4568761	No
2003	1327	1327.0	0.0	0.0	Stereological principles for morphometry in electron microscopic cytology.	E R Weibel	Int Rev Cytol	1969	4899604	No
2004	1327	1327.0	32.36	32.4	Two pathogenetic types of endometrial carcinoma.	J V Bokhman	Gynecol Oncol	1983	6822361	Yes
2005	1327	1327.0	25.08	25.1	The DNA methyltransferases of mammals.	T H Bestor	Hum Mol Genet	2000	11005794	No
2006	1327	1327.0	35.73	35.7	Hydrogels for biomedical applications.	Allan S Hoffman	Adv Drug Deliv Rev	2002	11755703	No
2007	2651	1325.5	83.11	41.6	From best evidence to best practice: effective implementation of change in patients' care.	Richard Grol, Jeremy Grimshaw	Lancet	2003	14568747	No
2008	2651	1325.5	69.02	34.5	Unravelling the pathogenesis of inflammatory bowel disease.	R J Xavier, D K Podolsky	Nature	2007	17653185	No
2009	1325	1325.0	25.67	25.7	Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy.	M G Gustafsson	J Microsc	2000	10810003	Yes
2010	1325	1325.0	117.55	117.5	Minimap2: pairwise alignment for nucleotide sequences.	Heng Li	Bioinformatics	2018	29750242	Yes
2011	3973	1324.3	142.53	47.5	Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration.	Helga Thorvaldsdóttir, James T Robinson, Jill P Mesirov	Brief Bioinform	2013	22517427	Yes
2012	1324	1324.0	64.99	65.0	Molecular pathology of schizophrenia: more than one disease process?	T J Crow	Br Med J	1980	6101544	No
2013	1324	1324.0	36.25	36.2	Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies.	S L Friedman	N Engl J Med	1993	8502273	No
2014	1324	1324.0	34.73	34.7	The amygdala modulates the consolidation of memories of emotionally arousing experiences.	James L McGaugh	Annu Rev Neurosci	2004	15217324	No
2015	3971	1323.7	130.86	43.6	Estimating the mean and variance from the median, range, and the size of a sample.	Stela Pudar Hozo, Benjamin Djulbegovic, Iztok Hozo	BMC Med Res Methodol	2005	15840177	Yes
2016	2647	1323.5	0.0	0.0	Immunization of dissociated spleen cell cultures from normal mice.	R I Mishell, R W Dutton	J Exp Med	1967	6034749	Yes
2017	2647	1323.5	68.74	34.4	Molecular beacons: probes that fluoresce upon hybridization.	S Tyagi, F R Kramer	Nat Biotechnol	1996	9630890	Yes
2018	2646	1323.0	94.95	47.5	A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels.	C M Tsai, C E Frasch	Anal Biochem	1982	6176137	Yes
2019	1323	1323.0	81.91	81.9	Deep learning in neural networks: an overview.	Jürgen Schmidhuber	Neural Netw	2015	25462637	No
2020	2644	1322.0	54.61	27.3	Cancer genes and the pathways they control.	Bert Vogelstein, Kenneth W Kinzler	Nat Med	2004	15286780	No
2021	2644	1322.0	56.6	28.3	Intrinsically unstructured proteins and their functions.	H Jane Dyson, Peter E Wright	Nat Rev Mol Cell Biol	2005	15738986	No
2022	3964	1321.3	119.71	39.9	Regularization Paths for Generalized Linear Models via Coordinate Descent.	Jerome Friedman, Trevor Hastie, Rob Tibshirani	J Stat Softw	2010	20808728	Yes
2023	2642	1321.0	0.0	0.0	Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.	G Blobel, B Dobberstein	J Cell Biol	1975	811671	Yes
2024	9241	1320.1	459.9	65.7	limma powers differential expression analyses for RNA-sequencing and microarray studies.	Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth	Nucleic Acids Res	2015	25605792	Yes
2025	1320	1320.0	0.0	0.0	Origin of concatemeric T7 DNA.	J D Watson	Nat New Biol	1972	4507727	Yes
2026	1320	1320.0	27.22	27.2	Dimerization of cell surface receptors in signal transduction.	C H Heldin	Cell	1995	7834741	No
2027	1320	1320.0	47.05	47.0	The polyvagal perspective.	Stephen W Porges	Biol Psychol	2007	17049418	No
2028	1320	1320.0	0.0	0.0	The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models.	R C Lewontin	Genetics	1964	17248194	Yes
2029	2638	1319.0	0.0	0.0	Virus interference. I. The interferon.	A Isaacs, J Lindenmann	Proc R Soc Lond B Biol Sci	1957	13465720	Yes
2030	1319	1319.0	0.0	0.0	A quantitative immunochemical measure of the primary interaction between I BSA and antibody.	R S Farr	J Infect Dis	1958	13611294	Yes
2031	1318	1318.0	0.0	0.0	Renin-angiotensin system: biochemistry and mechanisms of action.	M J Peach	Physiol Rev	1977	191856	No
2032	1318	1318.0	33.64	33.6	The use of nanocrystals in biological detection.	Paul Alivisatos	Nat Biotechnol	2004	14704706	Yes
2033	1317	1317.0	47.65	47.6	Neuropeptide Y: complete amino acid sequence of the brain peptide.	K Tatemoto	Proc Natl Acad Sci U S A	1982	6957876	Yes
2034	1317	1317.0	0.0	0.0	Cellular resistance to infection.	G B Mackaness	J Exp Med	1962	14467923	Yes
2035	2633	1316.5	60.63	30.3	Self-assembly at all scales.	George M Whitesides, Bartosz Grzybowski	Science	2002	11923529	Yes
2036	5265	1316.2	125.19	31.3	Quantitative monitoring of gene expression patterns with a complementary DNA microarray.	M Schena, D Shalon, R W Davis, P O Brown	Science	1995	7569999	Yes
2037	2632	1316.0	51.43	25.7	Oncogenic kinase signalling.	P Blume-Jensen, T Hunter	Nature	2001	11357143	No
2038	1316	1316.0	32.18	32.2	Neurotrophin-regulated signalling pathways.	Louis F Reichardt	Philos Trans R Soc Lond B Biol Sci	2006	16939974	No
2039	2630	1315.0	0.0	0.0	Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans.	D H Figurski, D R Helinski	Proc Natl Acad Sci U S A	1979	377280	Yes
2040	1314	1314.0	26.16	26.2	Chromosomal translocations in human cancer.	T H Rabbitts	Nature	1994	7969446	No
2041	17081	1313.9	482.6	37.1	Clustal W and Clustal X version 2.0.	M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G Higgins	Bioinformatics	2007	17846036	Yes
2042	1313	1313.0	41.82	41.8	The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat.	L W Swanson	Brain Res Bull	1982	6816390	Yes
2043	1313	1313.0	0.0	0.0	The antidiuretic hormone and the factors which determine its release.	E B Verney	Proc R Soc Lond B Biol Sci	1947	18918876	Yes
2044	2623	1311.5	113.0	56.5	Regulation of microRNA biogenesis.	Minju Ha, V Narry Kim	Nat Rev Mol Cell Biol	2014	25027649	No
2045	1311	1311.0	0.0	0.0	Stimulus-secretion coupling: the concept and clues from chromaffin and other cells.	W W Douglas	Br J Pharmacol	1968	4882190	No
2046	2622	1311.0	60.77	30.4	Integrins and signal transduction pathways: the road taken.	E A Clark, J S Brugge	Science	1995	7716514	No
2047	1311	1311.0	36.28	36.3	The world health report 2002 - reducing risks, promoting healthy life.	J J Guilbert	Educ Health (Abingdon)	2003	14741909	Yes
2048	1310	1310.0	34.66	34.7	The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure.	K Kuwajima	Proteins	1989	2695928	No
2049	1310	1310.0	35.4	35.4	Fibronectin and its receptors.	E Ruoslahti	Annu Rev Biochem	1988	2972252	No
2050	1310	1310.0	0.0	0.0	Agammaglobulinemia.	O C Bruton	Pediatrics	1952	14929630	Yes
2051	2620	1310.0	119.92	60.0	Deciphering key features in protein structures with the new ENDscript server.	Xavier Robert, Patrice Gouet	Nucleic Acids Res	2014	24753421	Yes
2052	5239	1309.8	305.67	76.4	Prevalence of childhood and adult obesity in the United States, 2011-2012.	Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M Flegal	JAMA	2014	24570244	Yes
2053	1309	1309.0	0.0	0.0	Letter: Grading of angina pectoris.	L Campeau	Circulation	1976	947585	Yes
2054	1309	1309.0	30.7	30.7	The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes.	S E Kahn	Diabetologia	2003	12637977	No
2055	3927	1309.0	174.11	58.0	Molecular mechanisms of epithelial-mesenchymal transition.	Samy Lamouille, Jian Xu, Rik Derynck	Nat Rev Mol Cell Biol	2014	24556840	No
2056	1309	1309.0	88.89	88.9	The antibiotic resistance crisis: part 1: causes and threats.	C Lee Ventola	P T	2015	25859123	Yes
2057	1308	1308.0	42.99	43.0	History of the Rochester Epidemiology Project.	L J Melton	Mayo Clin Proc	1996	8594285	No
2058	2615	1307.5	59.91	30.0	Supercoil sequencing: a fast and simple method for sequencing plasmid DNA.	E Y Chen, P H Seeburg	DNA	1985	3996185	Yes
2059	2615	1307.5	96.52	48.3	Saliency, switching, attention and control: a network model of insula function.	Vinod Menon, Lucina Q Uddin	Brain Struct Funct	2010	20512370	No
2060	5226	1306.5	142.13	35.5	Most mammalian mRNAs are conserved targets of microRNAs.	Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel	Genome Res	2009	18955434	Yes
2061	1306	1306.0	44.7	44.7	Gene flow and the geographic structure of natural populations.	M Slatkin	Science	1987	3576198	Yes
2062	1305	1305.0	41.61	41.6	The phenomenon of the acute phase response.	I Kushner	Ann N Y Acad Sci	1982	7046585	No
2063	1305	1305.0	31.6	31.6	Apoptosis in cancer therapy: crossing the threshold.	D E Fisher	Cell	1994	8069905	No
2064	2610	1305.0	61.75	30.9	The pathophysiology and treatment of sepsis.	Richard S Hotchkiss, Irene E Karl	N Engl J Med	2003	12519925	No
2065	1305	1305.0	41.18	41.2	Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research.	M Robin DiMatteo	Med Care	2004	15076819	Yes
2066	1304	1304.0	34.23	34.2	N-heterocyclic carbenes: a new concept in organometallic catalysis.	Wolfgang A Herrmann	Angew Chem Int Ed Engl	2002	19750753	Yes
2067	2608	1304.0	72.42	36.2	Macrophage diversity enhances tumor progression and metastasis.	Bin-Zhi Qian, Jeffrey W Pollard	Cell	2010	20371344	No
2068	2607	1303.5	60.79	30.4	The RXR heterodimers and orphan receptors.	D J Mangelsdorf, R M Evans	Cell	1995	8521508	No
2069	3910	1303.3	98.0	32.7	The p53 tumour suppressor gene.	A J Levine, J Momand, C A Finlay	Nature	1991	2046748	No
2070	1303	1303.0	37.28	37.3	The matrix-degrading metalloproteinases.	L M Matrisian	Bioessays	1992	1445287	No
2071	1303	1303.0	43.99	44.0	Stress signalling pathways that impair prefrontal cortex structure and function.	Amy F T Arnsten	Nat Rev Neurosci	2009	19455173	No
2072	1303	1303.0	0.0	0.0	Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism.	H M Kalckar	J Biol Chem	1947	20285041	Yes
2073	2605	1302.5	78.36	39.2	Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9164317	Yes
2074	1302	1302.0	25.95	25.9	Epithelial-mesenchymal transitions in development and pathologies.	Jean Paul Thiery	Curr Opin Cell Biol	2003	14644200	No
2075	1301	1301.0	0.0	0.0	Electrophoretic separation of plasma lipoproteins in agarose gel.	R P Noble	J Lipid Res	1968	4176473	Yes
2076	1301	1301.0	28.16	28.2	Double identity for proteins of the Bcl-2 family.	J C Reed	Nature	1997	9194558	No
2077	1301	1301.0	29.55	29.6	A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other.	Dale R Nyholt	Am J Hum Genet	2004	14997420	Yes
2078	1300	1300.0	64.97	65.0	What's in a name? Qualitative description revisited.	Margarete Sandelowski	Res Nurs Health	2010	20014004	Yes
2079	1299	1299.0	50.57	50.6	Free-radical mechanisms in tissue injury.	T F Slater	Biochem J	1984	6383353	No
2080	1299	1299.0	29.76	29.8	Functions of the neurotrophins during nervous system development: what the knockouts are teaching us.	W D Snider	Cell	1994	8205613	No
2081	1299	1299.0	33.01	33.0	Tobacco smoke carcinogens and lung cancer.	S S Hecht	J Natl Cancer Inst	1999	10413421	No
2082	6495	1299.0	291.48	58.3	UCHIME improves sensitivity and speed of chimera detection.	Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob Knight	Bioinformatics	2011	21700674	Yes
2083	2597	1298.5	54.11	27.1	Wnt signalling in stem cells and cancer.	Tannishtha Reya, Hans Clevers	Nature	2005	15829953	No
2084	2597	1298.5	77.07	38.5	Materials for electrochemical capacitors.	Patrice Simon, Yury Gogotsi	Nat Mater	2008	18956000	Yes
2085	1297	1297.0	30.68	30.7	Hyaluronan: from extracellular glue to pericellular cue.	Bryan P Toole	Nat Rev Cancer	2004	15229478	No
2086	5187	1296.8	180.02	45.0	clusterProfiler: an R package for comparing biological themes among gene clusters.	Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu He	OMICS	2012	22455463	Yes
2087	3890	1296.7	89.92	30.0	Osteoclast differentiation and activation.	William J Boyle, W Scott Simonet, David L Lacey	Nature	2003	12748652	No
2088	1296	1296.0	36.89	36.9	The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.	R G Gerrity	Am J Pathol	1981	7234961	Yes
2089	1296	1296.0	54.29	54.3	Sample size in qualitative research.	M Sandelowski	Res Nurs Health	1995	7899572	Yes
2090	2590	1295.0	56.5	28.2	The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.	M S Brown, J L Goldstein	Cell	1997	9150132	No
2091	1295	1295.0	27.62	27.6	Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators.	R I Morimoto	Genes Dev	1998	9869631	No
2092	1295	1295.0	43.16	43.2	The functional gastrointestinal disorders and the Rome III process.	Douglas A Drossman	Gastroenterology	2006	16678553	No
2093	1295	1295.0	50.37	50.4	Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies.	Peter C Austin	Pharm Stat	2011	20925139	Yes
2094	1294	1294.0	31.47	31.5	Regulation of differentiation of vascular smooth muscle cells.	G K Owens	Physiol Rev	1995	7624392	No
2095	1294	1294.0	33.84	33.8	Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides.	Y Shai	Biochim Biophys Acta	1999	10590302	No
2096	1294	1294.0	29.53	29.5	Cancer of the ovary.	Stephen A Cannistra	N Engl J Med	2004	15590954	No
2097	1293	1293.0	41.78	41.8	Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia.	A A Grace	Neuroscience	1991	1676137	No
2098	2585	1292.5	67.17	33.6	Long short-term memory.	S Hochreiter, J Schmidhuber	Neural Comput	1997	9377276	Yes
2099	1292	1292.0	0.0	0.0	Stability of proteins: small globular proteins.	P L Privalov	Adv Protein Chem	1979	44431	No
2100	2584	1292.0	61.9	30.9	Production of single-stranded plasmid DNA.	J Vieira, J Messing	Methods Enzymol	1987	3323803	Yes
2101	1292	1292.0	50.23	50.2	Presidential address, 1980. Surprise!...Surprise?	E Donchin	Psychophysiology	1981	7280146	Yes
2102	1292	1292.0	30.21	30.2	Autophagy: from phenomenology to molecular understanding in less than a decade.	Daniel J Klionsky	Nat Rev Mol Cell Biol	2007	17712358	No
2103	3873	1291.0	102.71	34.2	Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system.	B Fischl, M I Sereno, A M Dale	Neuroimage	1999	9931269	Yes
2104	1290	1290.0	30.59	30.6	Molecular basis of long-term plasticity underlying addiction.	E J Nestler	Nat Rev Neurosci	2001	11252991	No
2105	1290	1290.0	36.37	36.4	Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease.	Michael F Holick	Am J Clin Nutr	2004	15585788	No
2106	1290	1290.0	47.44	47.4	The global impact of pre-eclampsia and eclampsia.	Lelia Duley	Semin Perinatol	2009	19464502	No
2107	1289	1289.0	33.2	33.2	A molecular view of microbial diversity and the biosphere.	N R Pace	Science	1997	9115194	No
2108	1289	1289.0	24.28	24.3	Chromatin modification and epigenetic reprogramming in mammalian development.	En Li	Nat Rev Genet	2002	12209141	No
2109	2577	1288.5	0.0	0.0	Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents.	L F Berkman, S L Syme	Am J Epidemiol	1979	425958	Yes
2110	1288	1288.0	28.24	28.2	The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats.	G B Morin	Cell	1989	2805070	Yes
2111	3863	1287.7	0.0	0.0	Improved method for the determination of blood glutathione.	E Beutler, O Duron, B M Kelly	J Lab Clin Med	1963	13967893	Yes
2112	2574	1287.0	0.0	0.0	Epidermal growth factor.	G Carpenter, S Cohen	Annu Rev Biochem	1979	382984	No
2113	2574	1287.0	0.0	0.0	A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants.	R L Juliano, V Ling	Biochim Biophys Acta	1976	990323	Yes
2114	2574	1287.0	0.0	0.0	A new scale of social desirability independent of psychopathology.	D P Crowne, D Marlowe	J Consult Psychol	1960	13813058	Yes
2115	2572	1286.0	0.0	0.0	Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens.	J A Ledbetter, L A Herzenberg	Immunol Rev	1979	398327	No
2116	1286	1286.0	0.0	0.0	Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents.	A Böyum	Scand J Clin Lab Invest Suppl	1968	4179066	Yes
2117	1286	1286.0	22.34	22.3	Cancer. Addiction to oncogenes--the Achilles heal of cancer.	I Bernard Weinstein	Science	2002	12098689	No
2118	2571	1285.5	59.75	29.9	Disruption of epithelial cell-matrix interactions induces apoptosis.	S M Frisch, H Francis	J Cell Biol	1994	8106557	Yes
2119	1285	1285.0	31.14	31.1	Receptors for epidermal growth factor and other polypeptide mitogens.	G Carpenter	Annu Rev Biochem	1987	3039909	No
2120	1285	1285.0	47.19	47.2	Substance P.	B Pernow	Pharmacol Rev	1983	6196797	No
2121	2570	1285.0	54.81	27.4	Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.	J M Kyriakis, J Avruch	Physiol Rev	2001	11274345	No
2122	1285	1285.0	45.25	45.2	Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains.	K Anders Ericsson	Acad Med	2004	15383395	No
2123	2570	1285.0	82.22	41.1	Protective and pathogenic functions of macrophage subsets.	Peter J Murray, Thomas A Wynn	Nat Rev Immunol	2011	21997792	No
2124	2568	1284.0	0.0	0.0	Regulatory sequences involved in the promotion and termination of RNA transcription.	M Rosenberg, D Court	Annu Rev Genet	1979	94251	No
2125	1284	1284.0	0.0	0.0	Mate selection-a selection for a handicap.	A Zahavi	J Theor Biol	1975	1195756	Yes
2126	1284	1284.0	34.81	34.8	Signaling through phosphatidylcholine breakdown.	J H Exton	J Biol Chem	1990	2104616	No
2127	1284	1284.0	34.29	34.3	Phylogenies from molecular sequences: inference and reliability.	J Felsenstein	Annu Rev Genet	1988	3071258	No
2128	1284	1284.0	26.55	26.6	Natively unfolded proteins: a point where biology waits for physics.	Vladimir N Uversky	Protein Sci	2002	11910019	No
2129	2568	1284.0	56.99	28.5	NMR View: A computer program for the visualization and analysis of NMR data.	B A Johnson, R A Blevins	J Biomol NMR	1994	22911360	Yes
2130	3850	1283.3	139.07	46.4	Structure-antioxidant activity relationships of flavonoids and phenolic acids.	C A Rice-Evans, N J Miller, G Paganga	Free Radic Biol Med	1996	8743980	Yes
2131	1283	1283.0	29.26	29.3	The ATP synthase--a splendid molecular machine.	P D Boyer	Annu Rev Biochem	1997	9242922	No
2132	1283	1283.0	35.69	35.7	A note on robust variance estimation for cluster-correlated data.	R L Williams	Biometrics	2000	10877330	Yes
2133	1283	1283.0	24.33	24.3	CD95's deadly mission in the immune system.	P H Krammer	Nature	2000	11048730	No
2134	2566	1283.0	51.67	25.8	Autophagy as a regulated pathway of cellular degradation.	D J Klionsky, S D Emr	Science	2000	11099404	No
2135	1283	1283.0	0.0	0.0	The Relation Of Recombination To Mutational Advance.	H J Muller	Mutat Res	1964	14195748	Yes
2136	1283	1283.0	32.68	32.7	Upconversion and anti-Stokes processes with f and d ions in solids.	François Auzel	Chem Rev	2004	14719973	Yes
2137	5130	1282.5	225.69	56.4	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	Int J Surg	2010	20171303	No
2138	2564	1282.0	60.29	30.1	A comparison of bayesian methods for haplotype reconstruction from population genotype data.	Matthew Stephens, Peter Donnelly	Am J Hum Genet	2003	14574645	Yes
2139	1282	1282.0	34.1	34.1	Origin, biogenesis, and activity of plant microRNAs.	Olivier Voinnet	Cell	2009	19239888	No
2140	1281	1281.0	0.0	0.0	Cardiovascular and renal actions of dopamine: potential clinical applications.	L I Goldberg	Pharmacol Rev	1972	4554480	No
2141	5121	1280.2	128.58	32.1	Improved prediction of signal peptides: SignalP 3.0.	Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren Brunak	J Mol Biol	2004	15223320	Yes
2142	1280	1280.0	0.0	0.0	Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action.	J H Luft	Anat Rec	1971	4108333	Yes
2143	1279	1279.0	85.13	85.1	The three column spine and its significance in the classification of acute thoracolumbar spinal injuries.	F Denis	Spine (Phila Pa 1976)	1983	6670016	Yes
2144	1278	1278.0	55.45	55.5	The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence.	E J Khantzian	Am J Psychiatry	1985	3904487	No
2145	1278	1278.0	32.95	33.0	Drug-induced prolongation of the QT interval.	Dan M Roden	N Engl J Med	2004	14999113	No
2146	2555	1277.5	76.27	38.1	Lipid rafts as a membrane-organizing principle.	Daniel Lingwood, Kai Simons	Science	2010	20044567	No
2147	3831	1277.0	183.2	61.1	Risk factors for falls among elderly persons living in the community.	M E Tinetti, M Speechley, S F Ginter	N Engl J Med	1988	3205267	Yes
2148	1277	1277.0	0.0	0.0	Hippocampal electrical activity and voluntary movement in the rat.	C H Vanderwolf	Electroencephalogr Clin Neurophysiol	1969	4183562	Yes
2149	1277	1277.0	30.82	30.8	Lymphokine production by human T cells in disease states.	S Romagnani	Annu Rev Immunol	1994	8011282	No
2150	1277	1277.0	35.58	35.6	The epidemiology of venous thromboembolism.	Richard H White	Circulation	2003	12814979	No
2151	1277	1277.0	39.99	40.0	Recent developments in isocyanide based multicomponent reactions in applied chemistry.	Alexander Dömling	Chem Rev	2006	16402771	No
2152	1277	1277.0	59.32	59.3	KDIGO clinical practice guidelines for acute kidney injury.	Arif Khwaja	Nephron Clin Pract	2012	22890468	No
2153	2552	1276.0	0.0	0.0	A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival.	B G Durie, S E Salmon	Cancer	1975	1182674	Yes
2154	1276	1276.0	24.24	24.2	Antigen-specific interaction between T and B cells.	A Lanzavecchia	Nature	1985	3157869	Yes
2155	1276	1276.0	44.79	44.8	Functional organization of central pathways regulating the cardiovascular system.	R A Dampney	Physiol Rev	1994	8171117	No
2156	2549	1274.5	47.5	23.8	New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites.	R D Gietz, A Sugino	Gene	1988	3073106	Yes
2157	1274	1274.0	33.82	33.8	The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.	T Szkudelski	Physiol Res	2001	11829314	No
2158	5094	1273.5	129.67	32.4	The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling.	Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten Schwede	Bioinformatics	2006	16301204	Yes
2159	2546	1273.0	43.09	21.5	Genetic transformation of Drosophila with transposable element vectors.	G M Rubin, A C Spradling	Science	1982	6289436	Yes
2160	1273	1273.0	34.43	34.4	The importance of the ratio of omega-6/omega-3 essential fatty acids.	A P Simopoulos	Biomed Pharmacother	2002	12442909	No
2161	2545	1272.5	55.14	27.6	A guided tour into subcellular colocalization analysis in light microscopy.	S Bolte, F P Cordelières	J Microsc	2006	17210054	Yes
2162	1272	1272.0	38.91	38.9	Diversity and ubiquity of K channels.	B Rudy	Neuroscience	1988	2457185	No
2163	1272	1272.0	23.76	23.8	The snail superfamily of zinc-finger transcription factors.	M Angela Nieto	Nat Rev Mol Cell Biol	2002	11994736	No
2164	1272	1272.0	46.78	46.8	A Social Neuroscience Perspective on Adolescent Risk-Taking.	Laurence Steinberg	Dev Rev	2008	18509515	Yes
2165	1271	1271.0	23.25	23.2	Regulatory T cells: key controllers of immunologic self-tolerance.	S Sakaguchi	Cell	2000	10850488	No
2166	2542	1271.0	81.81	40.9	A perspective on cancer cell metastasis.	Christine L Chaffer, Robert A Weinberg	Science	2011	21436443	No
2167	1271	1271.0	0.0	0.0	Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry.	Russell Lande	Evolution	1979	28568194	Yes
2168	2540	1270.0	87.64	43.8	Thermodynamics of protein association reactions: forces contributing to stability.	P D Ross, S Subramanian	Biochemistry	1981	7248271	Yes
2169	2539	1269.5	0.0	0.0	Glutathione peroxidase activity in selenium-deficient rat liver.	R A Lawrence, R F Burk	Biochem Biophys Res Commun	1976	971321	Yes
2170	2539	1269.5	91.05	45.5	Measuring emotion: the Self-Assessment Manikin and the Semantic Differential.	M M Bradley, P J Lang	J Behav Ther Exp Psychiatry	1994	7962581	Yes
2171	2538	1269.0	0.0	0.0	Establishment and characterization of a human histiocytic lymphoma cell line (U-937).	C Sundström, K Nilsson	Int J Cancer	1976	178611	Yes
2172	1269	1269.0	41.92	41.9	Somatostatin.	S Reichlin	N Engl J Med	1983	6139753	No
2173	1269	1269.0	29.28	29.3	Critical period plasticity in local cortical circuits.	Takao K Hensch	Nat Rev Neurosci	2005	16261181	No
2174	1268	1268.0	45.44	45.4	The self-medication hypothesis of substance use disorders: a reconsideration and recent applications.	E J Khantzian	Harv Rev Psychiatry	1997	9385000	No
2175	2535	1267.5	0.0	0.0	Functions of lysosomes.	C De Duve, R Wattiaux	Annu Rev Physiol	1966	5322983	No
2176	2535	1267.5	55.46	27.7	Liver regeneration.	G K Michalopoulos, M C DeFrances	Science	1997	9082986	No
2177	2533	1266.5	0.0	0.0	The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites.	J Shine, L Dalgarno	Proc Natl Acad Sci U S A	1974	4598299	Yes
2178	1266	1266.0	22.77	22.8	Clonal selection and learning in the antibody system.	K Rajewsky	Nature	1996	8657279	No
2179	1266	1266.0	29.01	29.0	Target-oriented and diversity-oriented organic synthesis in drug discovery.	S L Schreiber	Science	2000	10720315	No
2180	1266	1266.0	0.0	0.0	A New Weighting System For Mean Surface Temperature Of The Human Body.	N L Ramanathan	J Appl Physiol	1964	14173555	Yes
2181	2530	1265.0	0.0	0.0	A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms.	J A Horne, O Ostberg	Int J Chronobiol	1976	1027738	Yes
2182	1265	1265.0	48.03	48.0	The life and times of the Enterococcus.	B E Murray	Clin Microbiol Rev	1990	2404568	No
2183	1265	1265.0	0.0	0.0	The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C.	R G Khalifah	J Biol Chem	1971	4994926	Yes
2184	2528	1264.0	49.84	24.9	Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis.	M Fried, D M Crothers	Nucleic Acids Res	1981	6275366	Yes
2185	1264	1264.0	42.17	42.2	Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data.	Thomas Heberer	Toxicol Lett	2002	11988354	Yes
2186	1264	1264.0	33.86	33.9	Interoception: the sense of the physiological condition of the body.	A D Craig	Curr Opin Neurobiol	2003	12965300	No
2187	2526	1263.0	0.0	0.0	A rapid, sensitive, and specific method for the determination of protein in dilute solution.	W Schaffner, C Weissmann	Anal Biochem	1973	4128882	Yes
2188	3787	1262.3	118.79	39.6	Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria.	S van der Linden, H A Valkenburg, A Cats	Arthritis Rheum	1984	6231933	Yes
2189	2524	1262.0	0.0	0.0	Prediction of the secondary structure of proteins from their amino acid sequence.	P Y Chou, G D Fasman	Adv Enzymol Relat Areas Mol Biol	1978	364941	No
2190	1262	1262.0	51.1	51.1	Reliability and factor analysis of the Epworth Sleepiness Scale.	M W Johns	Sleep	1992	1519015	Yes
2191	1262	1262.0	40.36	40.4	Biological basis of the behavior of sick animals.	B L Hart	Neurosci Biobehav Rev	1988	3050629	No
2192	1262	1262.0	28.29	28.3	Stability and flexibility of epigenetic gene regulation in mammalian development.	Wolf Reik	Nature	2007	17522676	No
2193	3784	1261.3	105.37	35.1	TCS: a computer program to estimate gene genealogies.	M Clement, D Posada, K A Crandall	Mol Ecol	2000	11050560	Yes
2194	1261	1261.0	33.72	33.7	The aryl hydrocarbon receptor complex.	O Hankinson	Annu Rev Pharmacol Toxicol	1995	7598497	No
2195	3783	1261.0	103.18	34.4	The metabolic syndrome.	Robert H Eckel, Scott M Grundy, Paul Z Zimmet	Lancet	2005	15836891	No
2196	1261	1261.0	38.43	38.4	The debate over dopamine's role in reward: the case for incentive salience.	Kent C Berridge	Psychopharmacology (Berl)	2007	17072591	No
2197	2521	1260.5	62.53	31.3	Multipoint quantitative-trait linkage analysis in general pedigrees.	L Almasy, J Blangero	Am J Hum Genet	1998	9545414	Yes
2198	1260	1260.0	42.68	42.7	SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test.	B P O'Connor	Behav Res Methods Instrum Comput	2000	11029811	Yes
2199	2520	1260.0	88.35	44.2	The pathogenesis of rheumatoid arthritis.	Iain B McInnes, Georg Schett	N Engl J Med	2011	22150039	No
2200	1259	1259.0	0.0	0.0	The prevalence of 'alexithymic' characteristics in psychosomatic patients.	P E Sifneos	Psychother Psychosom	1973	4770536	Yes
2201	1259	1259.0	33.44	33.4	Supported membranes: scientific and practical applications.	E Sackmann	Science	1996	8539599	No
2202	1259	1259.0	35.41	35.4	Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications.	P Lips	Endocr Rev	2001	11493580	No
2203	1259	1259.0	43.64	43.6	The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme.	Poul Erik Petersen	Community Dent Oral Epidemiol	2003	15015736	Yes
2204	1259	1259.0	22.98	23.0	Protein modification by SUMO.	Erica S Johnson	Annu Rev Biochem	2004	15189146	No
2205	1259	1259.0	30.86	30.9	Cell signaling. H2O2, a necessary evil for cell signaling.	Sue Goo Rhee	Science	2006	16809515	Yes
2206	1258	1258.0	0.0	0.0	Structure and function of intercellular junctions.	L A Staehelin	Int Rev Cytol	1974	4611943	No
2207	1258	1258.0	42.32	42.3	Formation of glasses from liquids and biopolymers.	C A Angell	Science	1995	17770101	Yes
2208	6285	1257.0	0.0	0.0	Enzymatic determination of total serum cholesterol.	C C Allain, L S Poon, C S Chan, W Richmond, P C Fu	Clin Chem	1974	4818200	Yes
2209	1257	1257.0	0.0	0.0	Strategy and tactics in protein chemistry.	B S Hartley	Biochem J	1970	4923920	No
2210	2514	1257.0	76.68	38.3	What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes.	J Zhang, K F Yu	JAMA	1998	9832001	Yes
2211	1257	1257.0	33.86	33.9	Hemispheric asymmetry reduction in older adults: the HAROLD model.	Roberto Cabeza	Psychol Aging	2002	11931290	No
2212	1257	1257.0	23.96	24.0	The significance of responses of the genome to challenge.	B McClintock	Science	1984	15739260	No
2213	1257	1257.0	48.37	48.4	Functional and effective connectivity: a review.	Karl J Friston	Brain Connect	2011	22432952	No
2214	1256	1256.0	52.38	52.4	Error in medicine.	L L Leape	JAMA	1994	7503827	Yes
2215	1256	1256.0	26.19	26.2	SETOR: hardware-lighted three-dimensional solid model representations of macromolecules.	S V Evans	J Mol Graph	1993	8347566	Yes
2216	1256	1256.0	31.89	31.9	Apoptosis.	J J Cohen	Immunol Today	1993	8466628	No
2217	1256	1256.0	35.96	36.0	Synergy, antagonism, and what the chequerboard puts between them.	F C Odds	J Antimicrob Chemother	2003	12805255	No
2218	2510	1255.0	67.65	33.8	Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.	J L Weber, P E May	Am J Hum Genet	1989	2916582	Yes
2219	1255	1255.0	47.63	47.6	Quantitative methods in the review of epidemiologic literature.	S Greenland	Epidemiol Rev	1987	3678409	Yes
2220	1255	1255.0	43.21	43.2	Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells.	R Lotan	Biochim Biophys Acta	1980	6989400	No
2221	1255	1255.0	37.09	37.1	Bioactive microbial metabolites.	János Bérdy	J Antibiot (Tokyo)	2005	15813176	No
2222	1254	1254.0	26.29	26.3	Signal transduction via the MAP kinases: proceed at your own RSK.	J Blenis	Proc Natl Acad Sci U S A	1993	8392180	No
2223	3762	1254.0	94.4	31.5	Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies.	Daniel Falush, Matthew Stephens, Jonathan K Pritchard	Genetics	2003	12930761	Yes
2224	1254	1254.0	29.72	29.7	Mitochondria: dynamic organelles in disease, aging, and development.	David C Chan	Cell	2006	16814712	No
2225	1254	1254.0	46.67	46.7	Matching methods for causal inference: A review and a look forward.	Elizabeth A Stuart	Stat Sci	2010	20871802	Yes
2226	3760	1253.3	101.36	33.8	How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.	R M Sapolsky, L M Romero, A U Munck	Endocr Rev	2000	10696570	No
2227	2506	1253.0	78.77	39.4	miRBase: integrating microRNA annotation and deep-sequencing data.	Ana Kozomara, Sam Griffiths-Jones	Nucleic Acids Res	2011	21037258	Yes
2228	1252	1252.0	25.84	25.8	Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy.	R H Schwartz	Cell	1992	1335362	No
2229	1252	1252.0	0.0	0.0	Limitations of the application of fourfold table analysis to hospital data.	J Berkson	Biometrics	1946	21001024	Yes
2230	2504	1252.0	75.06	37.5	Molecular mechanisms of long noncoding RNAs.	Kevin C Wang, Howard Y Chang	Mol Cell	2011	21925379	No
2231	2500	1250.0	58.13	29.1	DNA sequence analysis with a modified bacteriophage T7 DNA polymerase.	S Tabor, C C Richardson	Proc Natl Acad Sci U S A	1987	3474623	Yes
2232	1249	1249.0	38.24	38.2	Osteoblast adhesion on biomaterials.	K Anselme	Biomaterials	2000	10711964	No
2233	2497	1248.5	69.12	34.6	Abdominal obesity and metabolic syndrome.	Jean-Pierre Després, Isabelle Lemieux	Nature	2006	17167477	No
2234	2497	1248.5	80.86	40.4	Astrocytes: biology and pathology.	Michael V Sofroniew, Harry V Vinters	Acta Neuropathol	2010	20012068	No
2235	1248	1248.0	28.77	28.8	Chemistry and biology of the immunophilins and their immunosuppressive ligands.	S L Schreiber	Science	1991	1702904	No
2236	1248	1248.0	28.37	28.4	Life, death, and the pursuit of apoptosis.	E White	Genes Dev	1996	8557188	No
2237	1248	1248.0	0.0	0.0	A modification of receptor theory.	R P Stephenson	Br J Pharmacol Chemother	1956	13383117	Yes
2238	1247	1247.0	44.77	44.8	Carnitine--metabolism and functions.	J Bremer	Physiol Rev	1983	6361812	No
2239	1247	1247.0	28.4	28.4	Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration.	T A Springer	Annu Rev Physiol	1995	7778885	No
2240	1247	1247.0	39.89	39.9	Ordinary magic. Resilience processes in development.	A S Masten	Am Psychol	2001	11315249	Yes
2241	3740	1246.7	83.95	28.0	Multidrug resistance in cancer: role of ATP-dependent transporters.	Michael M Gottesman, Tito Fojo, Susan E Bates	Nat Rev Cancer	2002	11902585	No
2242	2493	1246.5	83.82	41.9	The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.	W R Gibb, A J Lees	J Neurol Neurosurg Psychiatry	1988	2841426	No
2243	8723	1246.1	272.39	38.9	Cancer statistics, 2008.	Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J Thun	CA Cancer J Clin	2008	18287387	Yes
2244	1246	1246.0	27.3	27.3	Codon usage and tRNA content in unicellular and multicellular organisms.	T Ikemura	Mol Biol Evol	1985	3916708	No
2245	2492	1246.0	0.0	0.0	The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid.	B N Ames, D T Dubin	J Biol Chem	1960	13793161	Yes
2246	3737	1245.7	78.97	26.3	The versatility and universality of calcium signalling.	M J Berridge, P Lipp, M D Bootman	Nat Rev Mol Cell Biol	2000	11413485	No
2247	2491	1245.5	55.87	27.9	Mitochondrial control of cell death.	G Kroemer, J C Reed	Nat Med	2000	10802706	No
2248	2491	1245.5	62.99	31.5	Inflammation, stress, and diabetes.	Kathryn E Wellen, Gökhan S Hotamisligil	J Clin Invest	2005	15864338	No
2249	3734	1244.7	82.15	27.4	A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.	R Medzhitov, P Preston-Hurlburt, C A Janeway	Nature	1997	9237759	Yes
2250	2489	1244.5	55.49	27.7	Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information.	M Zuker, P Stiegler	Nucleic Acids Res	1981	6163133	Yes
2251	1244	1244.0	30.53	30.5	Short-term synaptic plasticity.	R S Zucker	Annu Rev Neurosci	1989	2648947	No
2252	2488	1244.0	66.31	33.2	Apoptosis, oncosis, and necrosis. An overview of cell death.	G Majno, I Joris	Am J Pathol	1995	7856735	No
2253	2486	1243.0	0.0	0.0	Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells.	A Fabiato, F Fabiato	J Physiol (Paris)	1979	533865	Yes
2254	1243	1243.0	20.64	20.6	Antigen receptor tail clue.	M Reth	Nature	1989	2927501	Yes
2255	2486	1243.0	87.88	43.9	The framing of decisions and the psychology of choice.	A Tversky, D Kahneman	Science	1981	7455683	Yes
2256	1243	1243.0	0.0	0.0	The effective period of preventive antibiotic action in experimental incisions and dermal lesions.	J F Burke	Surgery	1961	16722001	Yes
2257	1242	1242.0	30.37	30.4	Papillomavirus infections--a major cause of human cancers.	H zur Hausen	Biochim Biophys Acta	1996	8876633	No
2258	1242	1242.0	32.85	32.9	Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders.	R M Sapolsky	Arch Gen Psychiatry	2000	11015810	No
2259	1242	1242.0	35.61	35.6	Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects.	E B Hunziker	Osteoarthritis Cartilage	2002	12056848	No
2260	1241	1241.0	39.58	39.6	Graphene transistors.	Frank Schwierz	Nat Nanotechnol	2010	20512128	Yes
2261	1240	1240.0	67.15	67.2	The determinants of parenting: a process model.	J Belsky	Child Dev	1984	6705636	Yes
2262	1240	1240.0	62.54	62.5	Chronic illness as biographical disruption.	M Bury	Sociol Health Illn	1982	10260456	Yes
2263	1240	1240.0	34.18	34.2	Understanding biofilm resistance to antibacterial agents.	David Davies	Nat Rev Drug Discov	2003	12563302	No
2264	2478	1239.0	93.78	46.9	Universal chemical assay for the detection and determination of siderophores.	B Schwyn, J B Neilands	Anal Biochem	1987	2952030	Yes
2265	4955	1238.8	149.42	37.4	Reversible middle cerebral artery occlusion without craniectomy in rats.	E Z Longa, P R Weinstein, S Carlson, R Cummins	Stroke	1989	2643202	Yes
2266	2476	1238.0	73.12	36.6	Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.	J I Morgan, T Curran	Annu Rev Neurosci	1991	1903243	No
2267	1238	1238.0	25.86	25.9	Searching for genetic determinants in the new millennium.	N J Risch	Nature	2000	10866211	No
2268	1238	1238.0	26.71	26.7	The many faces of macrophage activation.	David M Mosser	J Leukoc Biol	2003	12554797	No
2269	1238	1238.0	43.03	43.0	Stress and disorders of the stress system.	George P Chrousos	Nat Rev Endocrinol	2009	19488073	No
2270	2475	1237.5	56.74	28.4	Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface.	D A Brown, J K Rose	Cell	1992	1531449	Yes
2271	1237	1237.0	0.0	0.0	Bee and wasp venoms.	E Habermann	Science	1972	4113805	No
2272	1237	1237.0	42.47	42.5	How is the level of free arachidonic acid controlled in mammalian cells?	R F Irvine	Biochem J	1982	6810878	No
2273	1237	1237.0	39.58	39.6	A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation.	Ozcan Erel	Clin Biochem	2004	15003729	Yes
2274	1237	1237.0	33.05	33.0	Clinical features of metastatic bone disease and risk of skeletal morbidity.	Robert E Coleman	Clin Cancer Res	2006	17062708	No
2275	1237	1237.0	39.2	39.2	Understanding organofluorine chemistry. An introduction to the C-F bond.	David O'Hagan	Chem Soc Rev	2008	18197347	No
2276	1236	1236.0	39.01	39.0	Strong localization of photons in certain disordered dielectric superlattices.	John	Phys Rev Lett	1987	10034761	Yes
2277	2472	1236.0	57.49	28.7	Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry.	Joshua E Elias, Steven P Gygi	Nat Methods	2007	17327847	Yes
2278	11122	1235.8	356.37	39.6	The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10.	D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C Dunbar	J Clin Psychiatry	1998	9881538	No
2279	3707	1235.7	113.31	37.8	I-TASSER: a unified platform for automated protein structure and function prediction.	Ambrish Roy, Alper Kucukural, Yang Zhang	Nat Protoc	2010	20360767	Yes
2280	2471	1235.5	74.72	37.4	The Measurement Of Selection On Correlated Characters.	Russell Lande, Stevan J Arnold	Evolution	1983	28556011	Yes
2281	2470	1235.0	45.92	23.0	Rab proteins as membrane organizers.	M Zerial, H McBride	Nat Rev Mol Cell Biol	2001	11252952	No
2282	2470	1235.0	52.14	26.1	Short-term synaptic plasticity.	Robert S Zucker, Wade G Regehr	Annu Rev Physiol	2002	11826273	No
2283	1235	1235.0	0.0	0.0	Sequential tests for the detection of linkage.	N E Morton	Am J Hum Genet	1955	13258560	Yes
2284	1235	1235.0	37.85	37.9	Treatment of infections associated with surgical implants.	Rabih O Darouiche	N Engl J Med	2004	15070792	No
2285	1235	1235.0	45.81	45.8	Phase retrieval algorithms: a comparison.	J R Fienup	Appl Opt	1982	20396114	Yes
2286	6173	1234.6	810.24	162.0	MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms.	Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro Tamura	Mol Biol Evol	2018	29722887	Yes
2287	1234	1234.0	0.0	0.0	The origin of the genetic code.	F H Crick	J Mol Biol	1968	4887876	Yes
2288	1234	1234.0	25.83	25.8	Endocytosis and molecular sorting.	I Mellman	Annu Rev Cell Dev Biol	1996	8970738	No
2289	1234	1234.0	23.18	23.2	c-Myc target genes involved in cell growth, apoptosis, and metabolism.	C V Dang	Mol Cell Biol	1999	9858526	No
2290	1234	1234.0	0.0	0.0	On the local reactions of the arterial wall to changes of internal pressure.	W M Bayliss	J Physiol	1902	16992618	Yes
2291	7401	1233.5	204.43	34.1	Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.	Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur Wheeler	N Engl J Med	2000	10793162	Yes
2292	1233	1233.0	45.08	45.1	The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria.	A Raine	Schizophr Bull	1991	1805349	Yes
2293	1233	1233.0	27.46	27.5	HIF-1: mediator of physiological and pathophysiological responses to hypoxia.	G L Semenza	J Appl Physiol (1985)	2000	10749844	No
2294	2465	1232.5	90.89	45.4	The stunned myocardium: prolonged, postischemic ventricular dysfunction.	E Braunwald, R A Kloner	Circulation	1982	6754130	No
2295	2464	1232.0	52.15	26.1	The molecular biology of axon guidance.	M Tessier-Lavigne, C S Goodman	Science	1996	8895455	No
2296	2464	1232.0	0.0	0.0	Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines.	G J Todaro, H Green	J Cell Biol	1963	13985244	Yes
2297	6158	1231.6	150.8	30.2	Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.	T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L Coffman	J Immunol	1986	2419430	Yes
2298	3694	1231.3	145.0	48.3	CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting.	Teresa C Horan, Mary Andrus, Margaret A Dudeck	Am J Infect Control	2008	18538699	No
2299	1231	1231.0	24.96	25.0	STATs: signal transducers and activators of transcription.	J N Ihle	Cell	1996	8608586	No
2300	1231	1231.0	60.57	60.6	Whatever next? Predictive brains, situated agents, and the future of cognitive science.	Andy Clark	Behav Brain Sci	2013	23663408	No
2301	1230	1230.0	30.75	30.8	The 'effective number of codons' used in a gene.	F Wright	Gene	1990	2110097	Yes
2302	6146	1229.2	191.83	38.4	Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication.	Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E Walters	Arch Gen Psychiatry	2005	15939839	Yes
2303	1229	1229.0	30.37	30.4	Proinflammatory cytokines.	C A Dinarello	Chest	2000	10936147	No
2304	2458	1229.0	64.98	32.5	Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering.	M P Lutolf, J A Hubbell	Nat Biotechnol	2005	15637621	No
2305	2458	1229.0	58.52	29.3	Cellular senescence: when bad things happen to good cells.	Judith Campisi, Fabrizio d'Adda di Fagagna	Nat Rev Mol Cell Biol	2007	17667954	No
2306	1229	1229.0	54.88	54.9	Cognitive reserve in ageing and Alzheimer's disease.	Yaakov Stern	Lancet Neurol	2012	23079557	No
2307	1228	1228.0	0.0	0.0	Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus.	P Rakic	J Comp Neurol	1971	4101340	Yes
2308	1228	1228.0	29.62	29.6	Refined structure of the nicotinic acetylcholine receptor at 4A resolution.	Nigel Unwin	J Mol Biol	2005	15701510	Yes
2309	1228	1228.0	47.46	47.5	Asthma phenotypes: the evolution from clinical to molecular approaches.	Sally E Wenzel	Nat Med	2012	22561835	No
2310	1227	1227.0	34.84	34.8	Tumor angiogenesis.	J Folkman	Adv Cancer Res	1985	2581424	No
2311	1227	1227.0	0.0	0.0	A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon.	A M Olovnikov	J Theor Biol	1973	4754905	Yes
2312	1227	1227.0	0.0	0.0	Disconnexion syndromes in animals and man. I.	N Geschwind	Brain	1965	5318481	No
2313	1227	1227.0	36.5	36.5	Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation.	P Willner	Psychopharmacology (Berl)	1997	9452163	No
2314	2454	1227.0	47.91	24.0	Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection.	C Li, W H Wong	Proc Natl Acad Sci U S A	2001	11134512	Yes
2315	2454	1227.0	55.45	27.7	LTP and LTD: an embarrassment of riches.	Robert C Malenka, Mark F Bear	Neuron	2004	15450156	No
2316	3680	1226.7	137.21	45.7	Global estimates of the prevalence of diabetes for 2010 and 2030.	J E Shaw, R A Sicree, P Z Zimmet	Diabetes Res Clin Pract	2010	19896746	Yes
2317	6130	1226.0	236.86	47.4	Evidence based medicine: what it is and what it isn't.	D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S Richardson	BMJ	1996	8555924	No
2318	2452	1226.0	80.13	40.1	Porosity of 3D biomaterial scaffolds and osteogenesis.	Vassilis Karageorgiou, David Kaplan	Biomaterials	2005	15860204	No
2319	1225	1225.0	22.43	22.4	Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture.	H E Ruley	Nature	1983	6308473	Yes
2320	1225	1225.0	27.3	27.3	Maintenance of C. elegans.	Theresa Stiernagle	WormBook	2006	18050451	No
2321	2449	1224.5	49.59	24.8	Prediction of complete gene structures in human genomic DNA.	C Burge, S Karlin	J Mol Biol	1997	9149143	Yes
2322	1224	1224.0	30.94	30.9	Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.	J Deisenhofer	Biochemistry	1981	7236608	Yes
2323	1224	1224.0	40.61	40.6	An application of prefrontal cortex function theory to cognitive aging.	R L West	Psychol Bull	1996	8831298	No
2324	2447	1223.5	62.58	31.3	Interneurons of the hippocampus.	T F Freund, G Buzsáki	Hippocampus	1996	8915675	No
2325	1223	1223.0	36.81	36.8	The origins of the developmental origins theory.	D J P Barker	J Intern Med	2007	17444880	No
2326	1223	1223.0	0.0	0.0	Observations on the isolated phrenic nerve diaphragm preparation of the rat.	E Bulbring	Br J Pharmacol Chemother	1946	20999334	Yes
2327	1222	1222.0	0.0	0.0	Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion.	P O Seglen	Exp Cell Res	1973	4358115	Yes
2328	1222	1222.0	37.46	37.5	Calcium channel modulation by neurotransmitters, enzymes and drugs.	H Reuter	Nature	1983	6131381	No
2329	2444	1222.0	62.07	31.0	Pharmacology and functions of metabotropic glutamate receptors.	P J Conn, J P Pin	Annu Rev Pharmacol Toxicol	1997	9131252	No
2330	1221	1221.0	0.0	0.0	A restriction point for control of normal animal cell proliferation.	A B Pardee	Proc Natl Acad Sci U S A	1974	4524638	Yes
2331	1221	1221.0	37.2	37.2	Circuitry and functional aspects of the insular lobe in primates including humans.	J R Augustine	Brain Res Brain Res Rev	1996	8957561	No
2332	3661	1220.3	167.62	55.9	In search of how people change. Applications to addictive behaviors.	J O Prochaska, C C DiClemente, J C Norcross	Am Psychol	1992	1329589	Yes
2333	2440	1220.0	0.0	0.0	Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.	G K McMaster, G G Carmichael	Proc Natl Acad Sci U S A	1977	73185	Yes
2334	2439	1219.5	95.77	47.9	Genome editing. The new frontier of genome engineering with CRISPR-Cas9.	Jennifer A Doudna, Emmanuelle Charpentier	Science	2014	25430774	No
2335	1219	1219.0	0.0	0.0	The intraclass correlation coefficient as a measure of reliability.	J J Bartko	Psychol Rep	1966	5942109	Yes
2336	2438	1219.0	63.45	31.7	Genetic dissection of complex traits.	E S Lander, N J Schork	Science	1994	8091226	No
2337	1219	1219.0	0.0	0.0	On the psychophysical law.	S S Stevens	Psychol Rev	1957	13441853	Yes
2338	6093	1218.6	0.0	0.0	Transection of the oesophagus for bleeding oesophageal varices.	R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R Williams	Br J Surg	1973	4541913	Yes
2339	1218	1218.0	38.11	38.1	Classification of chronic viral hepatitis: a need for reassessment.	P J Scheuer	J Hepatol	1991	1808228	No
2340	2435	1217.5	76.95	38.5	Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.	J E Hixson, D T Vernier	J Lipid Res	1990	2341813	Yes
2341	2435	1217.5	63.95	32.0	The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity.	Clay B Holroyd, Michael G H Coles	Psychol Rev	2002	12374324	Yes
2342	2435	1217.5	168.07	84.0	Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees.	Ivica Letunic, Peer Bork	Nucleic Acids Res	2016	27095192	Yes
2343	1217	1217.0	0.0	0.0	The critical incident technique.	J C Flanagan	Psychol Bull	1954	13177800	Yes
2344	1216	1216.0	39.56	39.6	The Neuropsychiatric Inventory: assessing psychopathology in dementia patients.	J L Cummings	Neurology	1997	9153155	No
2345	1216	1216.0	24.69	24.7	Cytokines induce the development of functionally heterogeneous T helper cell subsets.	A O'Garra	Immunity	1998	9529145	No
2346	7294	1215.7	275.01	45.8	TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions.	Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg	Genome Biol	2013	23618408	Yes
2347	1215	1215.0	31.6	31.6	Rapid evolution of a protein in vitro by DNA shuffling.	W P Stemmer	Nature	1994	8047147	Yes
2348	2429	1214.5	61.22	30.6	Molecular mechanisms of action of steroid/thyroid receptor superfamily members.	M J Tsai, B W O'Malley	Annu Rev Biochem	1994	7979245	No
2349	2429	1214.5	74.51	37.3	Epidemiology of invasive candidiasis: a persistent public health problem.	M A Pfaller, D J Diekema	Clin Microbiol Rev	2007	17223626	No
2350	2429	1214.5	71.94	36.0	Regulation of chromatin by histone modifications.	Andrew J Bannister, Tony Kouzarides	Cell Res	2011	21321607	No
2351	1214	1214.0	0.0	0.0	The biologic clock: the mitochondria?	D Harman	J Am Geriatr Soc	1972	5016631	Yes
2352	2428	1214.0	0.0	0.0	High resolution acrylamide gel electrophoresis of histones.	S Panyim, R Chalkley	Arch Biochem Biophys	1969	5778650	Yes
2353	1214	1214.0	27.04	27.0	Heterotrimeric G proteins: organizers of transmembrane signals.	E J Neer	Cell	1995	7834744	No
2354	1214	1214.0	31.04	31.0	Endothelial-leukocyte adhesion molecules.	M P Bevilacqua	Annu Rev Immunol	1993	8476577	No
2355	1214	1214.0	28.95	28.9	Oxyradicals and DNA damage.	L J Marnett	Carcinogenesis	2000	10688856	No
2356	1214	1214.0	29.72	29.7	Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?	Rui Wang	FASEB J	2002	12409322	Yes
2357	2428	1214.0	0.0	0.0	Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies.	H A Edmondson, P E Steiner	Cancer	1954	13160935	Yes
2358	1214	1214.0	0.0	0.0	Diversity in tropical rain forests and coral reefs.	J H Connell	Science	1978	17840770	Yes
2359	1214	1214.0	43.6	43.6	Aging, cellular senescence, and cancer.	Judith Campisi	Annu Rev Physiol	2013	23140366	No
2360	1213	1213.0	42.9	42.9	The theoretical bases of indirect calorimetry: a review.	E Ferrannini	Metabolism	1988	3278194	No
2361	2426	1213.0	88.58	44.3	Total energy intake: implications for epidemiologic analyses.	W Willett, M J Stampfer	Am J Epidemiol	1986	3521261	No
2362	1213	1213.0	46.44	46.4	UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure.	D W Russell	J Pers Assess	1996	8576833	Yes
2363	1213	1213.0	41.0	41.0	The law of attrition.	Gunther Eysenbach	J Med Internet Res	2005	15829473	Yes
2364	1213	1213.0	31.07	31.1	Fast and robust fixed-point algorithms for independent component analysis.	A Hyvärinen	IEEE Trans Neural Netw	1999	18252563	Yes
2365	2425	1212.5	67.93	34.0	Nitric oxide synthases: roles, tolls, and controls.	C Nathan, Q W Xie	Cell	1994	7522969	No
2366	1212	1212.0	33.98	34.0	Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections.	F Hefti	J Neurosci	1986	3746405	Yes
2367	1212	1212.0	46.36	46.4	The structure of beta-lactamases.	R P Ambler	Philos Trans R Soc Lond B Biol Sci	1980	6109327	Yes
2368	2423	1211.5	65.36	32.7	The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes.	Daniel J Drucker, Michael A Nauck	Lancet	2006	17098089	No
2369	2423	1211.5	77.75	38.9	Genome regulation by long noncoding RNAs.	John L Rinn, Howard Y Chang	Annu Rev Biochem	2012	22663078	No
2370	1211	1211.0	31.21	31.2	The mitochondrial electron transport and oxidative phosphorylation system.	Y Hatefi	Annu Rev Biochem	1985	2862839	No
2371	1211	1211.0	21.62	21.6	The economics of ribosome biosynthesis in yeast.	J R Warner	Trends Biochem Sci	1999	10542411	No
2372	2422	1211.0	69.0	34.5	Bronchopulmonary dysplasia.	A H Jobe, E Bancalari	Am J Respir Crit Care Med	2001	11401896	No
2373	1211	1211.0	28.55	28.6	Topoisomerase I inhibitors: camptothecins and beyond.	Yves Pommier	Nat Rev Cancer	2006	16990856	No
2374	2421	1210.5	71.88	35.9	The gut microbiota shapes intestinal immune responses during health and disease.	June L Round, Sarkis K Mazmanian	Nat Rev Immunol	2009	19343057	No
2375	2421	1210.5	61.3	30.6	The DNA damage response: making it safe to play with knives.	Alberto Ciccia, Stephen J Elledge	Mol Cell	2010	20965415	No
2376	1210	1210.0	22.77	22.8	SUMO: a history of modification.	Ronald T Hay	Mol Cell	2005	15808504	No
2377	2419	1209.5	64.73	32.4	Powering the planet: chemical challenges in solar energy utilization.	Nathan S Lewis, Daniel G Nocera	Proc Natl Acad Sci U S A	2006	17043226	Yes
2378	2417	1208.5	55.59	27.8	Escaping free-energy minima.	Alessandro Laio, Michele Parrinello	Proc Natl Acad Sci U S A	2002	12271136	Yes
2379	2416	1208.0	39.55	19.8	A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback.	D Tautz, C Pfeifle	Chromosoma	1989	2476281	Yes
2380	3624	1208.0	97.64	32.5	Cognitive and emotional influences in anterior cingulate cortex.	Bush, Luu, Posner	Trends Cogn Sci	2000	10827444	Yes
2381	2416	1208.0	46.15	23.1	Live or let die: the cell's response to p53.	Karen H Vousden, Xin Lu	Nat Rev Cancer	2002	12154352	No
2382	1208	1208.0	33.76	33.8	Genetic consequences of climatic oscillations in the Quaternary.	G M Hewitt	Philos Trans R Soc Lond B Biol Sci	2004	15101575	No
2383	6036	1207.2	156.8	31.4	Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies.	Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory Collins	Lancet	2002	12493255	Yes
2384	1207	1207.0	38.29	38.3	Linkage map of Escherichia coli K-12, edition 7.	B J Bachmann	Microbiol Rev	1983	6348505	No
2385	1207	1207.0	35.28	35.3	Peptide antibiotics and their role in innate immunity.	H G Boman	Annu Rev Immunol	1995	7612236	No
2386	1207	1207.0	38.58	38.6	Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES).	Gunther Eysenbach	J Med Internet Res	2004	15471760	No
2387	1207	1207.0	33.06	33.1	Marine viruses--major players in the global ecosystem.	Curtis A Suttle	Nat Rev Microbiol	2007	17853907	No
2388	1207	1207.0	41.47	41.5	Signal transduction by reactive oxygen species.	Toren Finkel	J Cell Biol	2011	21746850	No
2389	2413	1206.5	51.93	26.0	Regulated portals of entry into the cell.	Sean D Conner, Sandra L Schmid	Nature	2003	12621426	No
2390	6031	1206.2	193.21	38.6	Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.	J S Beckman, T W Beckman, J Chen, P A Marshall, B A Freeman	Proc Natl Acad Sci U S A	1990	2154753	Yes
2391	13268	1206.2	380.4	34.6	The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.	Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J Roccella	JAMA	2003	12748199	No
2392	1206	1206.0	59.37	59.4	New norms of upper limb fat and muscle areas for assessment of nutritional status.	A R Frisancho	Am J Clin Nutr	1981	6975564	Yes
2393	2412	1206.0	59.14	29.6	Cancer stem cells in solid tumours: accumulating evidence and unresolved questions.	Jane E Visvader, Geoffrey J Lindeman	Nat Rev Cancer	2008	18784658	No
2394	2412	1206.0	112.84	56.4	Natural products as sources of new drugs over the 30 years from 1981 to 2010.	David J Newman, Gordon M Cragg	J Nat Prod	2012	22316239	No
2395	2411	1205.5	0.0	0.0	Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty.	J M Tanner, R H Whitehouse	Arch Dis Child	1976	952550	Yes
2396	4821	1205.2	143.28	35.8	Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.	N Weidner, J P Semple, W R Welch, J Folkman	N Engl J Med	1991	1701519	Yes
2397	1205	1205.0	26.14	26.1	Antigen-presenting function of the macrophage.	E R Unanue	Annu Rev Immunol	1984	6242349	No
2398	1205	1205.0	34.92	34.9	Polycystic ovary syndrome.	David A Ehrmann	N Engl J Med	2005	15788499	No
2399	2410	1205.0	70.31	35.2	Molecular replacement with MOLREP.	Alexei Vagin, Alexei Teplyakov	Acta Crystallogr D Biol Crystallogr	2010	20057045	Yes
2400	3614	1204.7	86.62	28.9	Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides.	Christian W Tornøe, Caspar Christensen, Morten Meldal	J Org Chem	2002	11975567	Yes
2401	1204	1204.0	29.83	29.8	Bcl-2 initiates a new category of oncogenes: regulators of cell death.	S J Korsmeyer	Blood	1992	1498330	No
2402	1204	1204.0	55.43	55.4	Continuous improvement as an ideal in health care.	D M Berwick	N Engl J Med	1989	2909878	Yes
2403	2407	1203.5	0.0	0.0	The Aggregation Of Blood Platelets.	G V Born, M J Cross	J Physiol	1963	14056485	Yes
2404	2406	1203.0	74.38	37.2	An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat.	Sun Ho Kim, Jin Mo Chung	Pain	1992	1333581	Yes
2405	1203	1203.0	0.0	0.0	Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology.	W D Hamilton	Science	1967	6021675	Yes
2406	2406	1203.0	79.12	39.6	Oxidative mechanisms in the toxicity of metal ions.	S J Stohs, D Bagchi	Free Radic Biol Med	1995	7744317	No
2407	1203	1203.0	27.84	27.8	Physiological and molecular basis of thyroid hormone action.	P M Yen	Physiol Rev	2001	11427693	No
2408	2406	1203.0	95.75	47.9	The integrative review: updated methodology.	Robin Whittemore, Kathleen Knafl	J Adv Nurs	2005	16268861	Yes
2409	1202	1202.0	34.05	34.0	Diversity of group types, regulation, and function of phospholipase A2.	E A Dennis	J Biol Chem	1994	8175726	No
2410	1202	1202.0	25.41	25.4	MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation.	R N Germain	Cell	1994	8293464	No
2411	1202	1202.0	26.34	26.3	Dendritic cells: unique leukocyte populations which control the primary immune response.	D N Hart	Blood	1997	9345009	No
2412	1202	1202.0	24.43	24.4	Mechanisms of caspase activation and inhibition during apoptosis.	Yigong Shi	Mol Cell	2002	11931755	No
2413	1202	1202.0	0.0	0.0	The anterior approach for removal of ruptured cervical disks.	R B Cloward	J Neurosurg	1958	13599052	Yes
2414	1202	1202.0	0.0	0.0	Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.	J M Van Rossum	Arch Int Pharmacodyn Ther	1963	13996119	Yes
2415	1202	1202.0	35.24	35.2	Adult mesenchymal stem cells for tissue engineering versus regenerative medicine.	Arnold I Caplan	J Cell Physiol	2007	17620285	No
2416	1202	1202.0	41.53	41.5	Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations.	Chao-Jun Li	Acc Chem Res	2009	19220064	Yes
2417	3605	1201.7	112.8	37.6	A rapid bootstrap algorithm for the RAxML Web servers.	Alexandros Stamatakis, Paul Hoover, Jacques Rougemont	Syst Biol	2008	18853362	Yes
2418	2403	1201.5	65.79	32.9	Cell signaling by receptor tyrosine kinases.	Mark A Lemmon, Joseph Schlessinger	Cell	2010	20602996	No
2419	3604	1201.3	110.43	36.8	Oxidants, antioxidants, and the degenerative diseases of aging.	B N Ames, M K Shigenaga, T M Hagen	Proc Natl Acad Sci U S A	1993	8367443	No
2420	1201	1201.0	40.45	40.5	Chlorophyll fluorescence: a probe of photosynthesis in vivo.	Neil R Baker	Annu Rev Plant Biol	2008	18444897	No
2421	3602	1200.7	129.7	43.2	A new method for off-line removal of ocular artifact.	G Gratton, M G Coles, E Donchin	Electroencephalogr Clin Neurophysiol	1983	6187540	Yes
2422	2401	1200.5	64.62	32.3	A globally coherent fingerprint of climate change impacts across natural systems.	Camille Parmesan, Gary Yohe	Nature	2003	12511946	Yes
2423	1199	1199.0	36.48	36.5	Qinghaosu (artemisinin): an antimalarial drug from China.	D L Klayman	Science	1985	3887571	No
2424	2398	1199.0	61.63	30.8	The free radical theory of aging matures.	K B Beckman, B N Ames	Physiol Rev	1998	9562038	No
2425	1199	1199.0	36.36	36.4	Invasive aspergillosis.	D W Denning	Clin Infect Dis	1998	9564455	No
2426	1199	1199.0	32.9	32.9	The human orbitofrontal cortex: linking reward to hedonic experience.	Morten L Kringelbach	Nat Rev Neurosci	2005	16136173	No
2427	1199	1199.0	33.05	33.0	Reconciling the chemistry and biology of reactive oxygen species.	Christine C Winterbourn	Nat Chem Biol	2008	18421291	No
2428	3594	1198.0	63.94	21.3	A system for stable expression of short interfering RNAs in mammalian cells.	Thijn R Brummelkamp, René Bernards, Reuven Agami	Science	2002	11910072	Yes
2429	1198	1198.0	33.52	33.5	Diagnosis of osteoporosis and assessment of fracture risk.	John A Kanis	Lancet	2002	12057569	No
2430	1198	1198.0	28.98	29.0	Mechanisms of foxp3+ T regulatory cell-mediated suppression.	Ethan M Shevach	Immunity	2009	19464986	No
2431	13176	1197.8	331.43	30.1	New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada.	P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G Gwyther	J Natl Cancer Inst	2000	10655437	No
2432	2395	1197.5	0.0	0.0	Post-embryonic cell lineages of the nematode, Caenorhabditis elegans.	J E Sulston, H R Horvitz	Dev Biol	1977	838129	Yes
2433	2394	1197.0	47.03	23.5	CpG islands in vertebrate genomes.	M Gardiner-Garden, M Frommer	J Mol Biol	1987	3656447	Yes
2434	1197	1197.0	32.56	32.6	Low density lipoprotein oxidation and its pathobiological significance.	D Steinberg	J Biol Chem	1997	9261091	No
2435	2394	1197.0	43.9	21.9	The DNA damage response: putting checkpoints in perspective.	B B Zhou, S J Elledge	Nature	2000	11100718	No
2436	1196	1196.0	27.21	27.2	Hybridization of denatured RNA transferred or dotted nitrocellulose paper.	P S Thomas	Methods Enzymol	1983	6194404	Yes
2437	1195	1195.0	23.84	23.8	microRNAs: tiny regulators with great potential.	V Ambros	Cell	2001	11779458	No
2438	2389	1194.5	68.45	34.2	What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?	K C Berridge, T E Robinson	Brain Res Brain Res Rev	1998	9858756	No
2439	2389	1194.5	80.03	40.0	Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art.	Johan W S Vlaeyen, Steven J Linton	Pain	2000	10781906	No
2440	2389	1194.5	62.24	31.1	Neuronal plasticity: increasing the gain in pain.	C J Woolf, M W Salter	Science	2000	10846153	No
2441	3583	1194.3	92.23	30.7	Long non-coding RNAs: insights into functions.	Tim R Mercer, Marcel E Dinger, John S Mattick	Nat Rev Genet	2009	19188922	No
2442	1194	1194.0	28.41	28.4	Growth factors and cancer.	S A Aaronson	Science	1991	1659742	No
2443	1194	1194.0	59.23	59.2	ROC methodology in radiologic imaging.	C E Metz	Invest Radiol	1986	3095258	No
2444	1194	1194.0	48.6	48.6	Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface.	E H Beachey	J Infect Dis	1981	7014727	No
2445	1194	1194.0	47.26	47.3	Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models.	T Florian Jaeger	J Mem Lang	2008	19884961	Yes
2446	4775	1193.8	217.31	54.3	Bayesian phylogenetics with BEAUti and the BEAST 1.7.	Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew Rambaut	Mol Biol Evol	2012	22367748	Yes
2447	1193	1193.0	29.8	29.8	Hereditary cancer, oncogenes, and antioncogenes.	A G Knudson	Cancer Res	1985	2983882	Yes
2448	2386	1193.0	75.24	37.6	CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure.	Mattias Jakobsson, Noah A Rosenberg	Bioinformatics	2007	17485429	Yes
2449	2385	1192.5	47.61	23.8	Checkpoints: controls that ensure the order of cell cycle events.	L H Hartwell, T A Weinert	Science	1989	2683079	No
2450	2384	1192.0	54.23	27.1	The pathophysiology of mitochondrial cell death.	Douglas R Green, Guido Kroemer	Science	2004	15286356	No
2451	1192	1192.0	37.1	37.1	Multiple imputation of discrete and continuous data by fully conditional specification.	Stef van Buuren	Stat Methods Med Res	2007	17621469	Yes
2452	1191	1191.0	34.81	34.8	Stress and depression.	Constance Hammen	Annu Rev Clin Psychol	2005	17716090	No
2453	3572	1190.7	88.64	29.5	Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?	Witold Filipowicz, Suvendra N Bhattacharyya, Nahum Sonenberg	Nat Rev Genet	2008	18197166	No
2454	1190	1190.0	27.26	27.3	The stem-cell niche as an entity of action.	David T Scadden	Nature	2006	16810242	No
2455	2379	1189.5	61.37	30.7	Rising incidence of hepatocellular carcinoma in the United States.	H B El-Serag, A C Mason	N Engl J Med	1999	10072408	Yes
2456	1189	1189.0	29.28	29.3	Reactive oxygen radicals in signaling and damage in the ischemic brain.	P H Chan	J Cereb Blood Flow Metab	2001	11149664	No
2457	2378	1189.0	82.98	41.5	Oxidative stress and diabetic complications.	Ferdinando Giacco, Michael Brownlee	Circ Res	2010	21030723	No
2458	4755	1188.8	113.24	28.3	Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.	Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J Thun	N Engl J Med	2003	12711737	Yes
2459	8317	1188.1	348.17	49.7	Development and validation of a geriatric depression screening scale: a preliminary report.	J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O Leirer	J Psychiatr Res	1982	7183759	Yes
2460	1188	1188.0	0.0	0.0	Campylobacter enteritis: a "new" disease.	M B Skirrow	Br Med J	1977	871765	Yes
2461	1188	1188.0	0.0	0.0	Assay of intestinal disaccharidases.	A Dahlqvist	Anal Biochem	1968	5636962	Yes
2462	1188	1188.0	26.25	26.2	The finer things in X-ray diffraction data collection.	J W Pflugrath	Acta Crystallogr D Biol Crystallogr	1999	10531521	Yes
2463	1188	1188.0	0.0	0.0	The diagnosis of ischaemic heart pain and intermittent claudication in field surveys.	G A Rose	Bull World Health Organ	1962	13974778	Yes
2464	2375	1187.5	75.52	37.8	The benefits of being present: mindfulness and its role in psychological well-being.	Kirk Warren Brown, Richard M Ryan	J Pers Soc Psychol	2003	12703651	Yes
2465	2375	1187.5	67.9	34.0	The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin.	W L Jorgensen, J Tirado-Rives	J Am Chem Soc	1988	27557051	Yes
2466	2374	1187.0	0.0	0.0	Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine.	J D Peuler, G A Johnson	Life Sci	1977	904439	Yes
2467	1187	1187.0	0.0	0.0	Studies on phosphatidylcholine vesicles. Formation and physical characteristics.	C Huang	Biochemistry	1969	5777332	Yes
2468	2374	1187.0	64.48	32.2	Leukocyte-endothelial adhesion molecules.	T M Carlos, J M Harlan	Blood	1994	7522621	No
2469	2373	1186.5	75.8	37.9	The cortical organization of speech processing.	Gregory Hickok, David Poeppel	Nat Rev Neurosci	2007	17431404	No
2470	2372	1186.0	0.0	0.0	Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats.	J Altman, G D Das	J Comp Neurol	1965	5861717	Yes
2471	1186	1186.0	45.77	45.8	Inflammation in atherosclerosis.	Peter Libby	Arterioscler Thromb Vasc Biol	2012	22895665	No
2472	2371	1185.5	45.23	22.6	DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.	Christopher J Bakkenist, Michael B Kastan	Nature	2003	12556884	Yes
2473	2371	1185.5	64.95	32.5	Therapeutic potential of resveratrol: the in vivo evidence.	Joseph A Baur, David A Sinclair	Nat Rev Drug Discov	2006	16732220	No
2474	1185	1185.0	35.11	35.1	Atopic dermatitis.	Thomas Bieber	N Engl J Med	2008	18385500	Yes
2475	7108	1184.7	187.08	31.2	A default mode of brain function.	M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L Shulman	Proc Natl Acad Sci U S A	2001	11209064	Yes
2476	2368	1184.0	0.0	0.0	Surgical risk as related to time of intervention in the repair of intracranial aneurysms.	W E Hunt, R M Hess	J Neurosurg	1968	5635959	Yes
2477	1184	1184.0	29.41	29.4	Somatostatin and its receptor family.	Y C Patel	Front Neuroendocrinol	1999	10433861	No
2478	1184	1184.0	34.19	34.2	The cancer stem cell: premises, promises and challenges.	Hans Clevers	Nat Med	2011	21386835	No
2479	2367	1183.5	54.72	27.4	Transforming gene product of Rous sarcoma virus phosphorylates tyrosine.	T Hunter, B M Sefton	Proc Natl Acad Sci U S A	1980	6246487	Yes
2480	2367	1183.5	64.03	32.0	Nanostructures in biodiagnostics.	Nathaniel L Rosi, Chad A Mirkin	Chem Rev	2005	15826019	No
2481	1183	1183.0	43.39	43.4	Transduction of psychosocial stress into the neurobiology of recurrent affective disorder.	R M Post	Am J Psychiatry	1992	1353322	No
2482	1183	1183.0	45.35	45.4	Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment.	S H Safe	Crit Rev Toxicol	1994	8037844	No
2483	1183	1183.0	38.5	38.5	Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?	Thomas Grobner	Nephrol Dial Transplant	2006	16431890	Yes
2484	1182	1182.0	28.7	28.7	Intracellular protein topogenesis.	G Blobel	Proc Natl Acad Sci U S A	1980	6929499	Yes
2485	1182	1182.0	0.0	0.0	The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma.	W G Duncombe	Clin Chim Acta	1964	14122498	Yes
2486	1182	1182.0	0.0	0.0	The cytoarchitectonic organization of the spinal cord in the cat.	B Rexed	J Comp Neurol	1952	14946260	Yes
2487	2362	1181.0	49.18	24.6	Gene silencing in cancer in association with promoter hypermethylation.	James G Herman, Stephen B Baylin	N Engl J Med	2003	14627790	No
2488	2361	1180.5	187.2	93.6	Natural Products as Sources of New Drugs from 1981 to 2014.	David J Newman, Gordon M Cragg	J Nat Prod	2016	26852623	No
2489	1180	1180.0	42.96	43.0	Multimodal approach to control postoperative pathophysiology and rehabilitation.	H Kehlet	Br J Anaesth	1997	9175983	No
2490	2360	1180.0	73.69	36.8	Mediation in experimental and nonexperimental studies: new procedures and recommendations.	Patrick E Shrout, Niall Bolger	Psychol Methods	2002	12530702	Yes
2491	1180	1180.0	30.47	30.5	The blood-brain barrier: bottleneck in brain drug development.	William M Pardridge	NeuroRx	2005	15717053	No
2492	1180	1180.0	0.0	0.0	A new readability yardstick.	R Flesch	J Appl Psychol	1948	18867058	Yes
2493	1179	1179.0	37.99	38.0	The pathogenesis of sepsis.	R C Bone	Ann Intern Med	1991	1872494	No
2494	2358	1179.0	74.58	37.3	Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India.	D Filmer, L H Pritchett	Demography	2001	11227840	Yes
2495	2358	1179.0	69.07	34.5	Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies.	Robert E W Hancock, Hans-Georg Sahl	Nat Biotechnol	2006	17160061	No
2496	2357	1178.5	118.25	59.1	A new initiative on precision medicine.	Francis S Collins, Harold Varmus	N Engl J Med	2015	25635347	Yes
2497	1178	1178.0	25.27	25.3	Caspase structure, proteolytic substrates, and function during apoptotic cell death.	D W Nicholson	Cell Death Differ	1999	10578171	No
2498	1178	1178.0	21.32	21.3	Cancer susceptibility and the functions of BRCA1 and BRCA2.	Ashok R Venkitaraman	Cell	2002	11832208	No
2499	1178	1178.0	53.01	53.0	MorphoJ: an integrated software package for geometric morphometrics.	Christian Peter Klingenberg	Mol Ecol Resour	2011	21429143	Yes
2500	2355	1177.5	45.8	22.9	The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.	T Maehama, J E Dixon	J Biol Chem	1998	9593664	Yes
2501	3532	1177.3	88.61	29.5	Thresholding of statistical maps in functional neuroimaging using the false discovery rate.	Christopher R Genovese, Nicole A Lazar, Thomas Nichols	Neuroimage	2002	11906227	Yes
2502	1177	1177.0	66.22	66.2	Psychosocial resilience and protective mechanisms.	Michael Rutter	Am J Orthopsychiatry	1987	3303954	No
2503	1177	1177.0	56.22	56.2	A cognitive approach to panic.	D M Clark	Behav Res Ther	1986	3741311	Yes
2504	1177	1177.0	0.0	0.0	Displaced proximal humeral fractures. I. Classification and evaluation.	C S Neer	J Bone Joint Surg Am	1970	5455339	Yes
2505	16467	1176.2	365.23	26.1	Crystallography & NMR system: A new software suite for macromolecular structure determination.	A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L Warren	Acta Crystallogr D Biol Crystallogr	1998	9757107	Yes
2506	2351	1175.5	56.87	28.4	Peroxisome proliferator-activated receptors: nuclear control of metabolism.	B Desvergne, W Wahli	Endocr Rev	1999	10529898	No
2507	1175	1175.0	30.62	30.6	Surrogate endpoints in clinical trials: definition and operational criteria.	R L Prentice	Stat Med	1989	2727467	Yes
2508	1175	1175.0	24.59	24.6	Morphogenetic roles of classic cadherins.	M Takeichi	Curr Opin Cell Biol	1995	8573335	No
2509	1175	1175.0	61.56	61.6	Optical properties of biological tissues: a review.	Steven L Jacques	Phys Med Biol	2013	23666068	No
2510	3523	1174.3	85.29	28.4	Dystrophin: the protein product of the Duchenne muscular dystrophy locus.	E P Hoffman, R H Brown, L M Kunkel	Cell	1987	3319190	Yes
2511	1174	1174.0	39.78	39.8	Interleukin-1 and the pathogenesis of the acute-phase response.	C A Dinarello	N Engl J Med	1984	6208485	No
2512	1174	1174.0	29.85	29.9	The neuropathology of schizophrenia. A critical review of the data and their interpretation.	P J Harrison	Brain	1999	10219775	No
2513	2348	1174.0	87.31	43.7	How useful is SBF in predicting in vivo bone bioactivity?	Tadashi Kokubo, Hiroaki Takadama	Biomaterials	2006	16448693	No
2514	1174	1174.0	33.06	33.1	Microbial influences in inflammatory bowel diseases.	R Balfour Sartor	Gastroenterology	2008	18242222	No
2515	2346	1173.0	0.0	0.0	Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.	R W Butcher, E W Sutherland	J Biol Chem	1962	13875173	Yes
2516	1172	1172.0	33.7	33.7	Emotion regulation: affective, cognitive, and social consequences.	James J Gross	Psychophysiology	2002	12212647	No
2517	1172	1172.0	0.0	0.0	A sensitive method for the assay of 5-hydroxytryptamine.	J R Vane	Br J Pharmacol Chemother	1957	13460242	Yes
2518	1172	1172.0	28.92	28.9	The path to ubiquitous and low-cost organic electronic appliances on plastic.	Stephen R Forrest	Nature	2004	15118718	Yes
2519	1171	1171.0	37.69	37.7	Antioxidants in human health and disease.	B Halliwell	Annu Rev Nutr	1996	8839918	No
2520	1171	1171.0	31.33	31.3	Drug delivery and targeting.	R Langer	Nature	1998	9579855	No
2521	1171	1171.0	0.0	0.0	A chemical method for the determination of oestriol, oestrone and oestradiol in human urine.	J B Brown	Biochem J	1955	14389222	Yes
2522	1171	1171.0	28.52	28.5	Oxidative stress in neurodegeneration: cause or consequence?	Julie K Andersen	Nat Med	2004	15298006	No
2523	1171	1171.0	0.0	0.0	Histological demonstration of mucin after periodic acid.	J F A McMANUS	Nature	1946	20995486	Yes
2524	7024	1170.7	179.74	30.0	GROMACS: fast, flexible, and free.	David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C Berendsen	J Comput Chem	2005	16211538	Yes
2525	3511	1170.3	118.25	39.4	Simultaneous inference in general parametric models.	Torsten Hothorn, Frank Bretz, Peter Westfall	Biom J	2008	18481363	No
2526	1170	1170.0	0.0	0.0	Nontuberculous mycobacteria and associated diseases.	E Wolinsky	Am Rev Respir Dis	1979	369415	No
2527	1170	1170.0	36.28	36.3	The mysteries of lipoprotein(a).	G Utermann	Science	1989	2530631	No
2528	1170	1170.0	34.81	34.8	Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes.	W Sieghart	Pharmacol Rev	1995	7568326	No
2529	1170	1170.0	29.21	29.2	Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase.	P Kuzmic	Anal Biochem	1996	8660575	Yes
2530	3508	1169.3	86.16	28.7	Global and societal implications of the diabetes epidemic.	P Zimmet, K G Alberti, J Shaw	Nature	2001	11742409	No
2531	1169	1169.0	36.71	36.7	Biosynthesis and metabolism of endothelium-derived nitric oxide.	L J Ignarro	Annu Rev Pharmacol Toxicol	1990	2188578	No
2532	1169	1169.0	40.87	40.9	The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension.	N M Kaplan	Arch Intern Med	1989	2662932	No
2533	1169	1169.0	26.06	26.1	The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression.	S J Collins	Blood	1987	3311197	No
2534	3507	1169.0	102.39	34.1	Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections.	H King, R E Aubert, W H Herman	Diabetes Care	1998	9727886	Yes
2535	1169	1169.0	32.38	32.4	Plasmonics: merging photonics and electronics at nanoscale dimensions.	Ekmel Ozbay	Science	2006	16410515	Yes
2536	3505	1168.3	122.71	40.9	Factor structure of the Barratt impulsiveness scale.	J H Patton, M S Stanford, E S Barratt	J Clin Psychol	1995	8778124	Yes
2537	3505	1168.3	74.11	24.7	Large-scale analysis of the yeast proteome by multidimensional protein identification technology.	M P Washburn, D Wolters, J R Yates	Nat Biotechnol	2001	11231557	Yes
2538	1168	1168.0	0.0	0.0	Measurement of feelings using visual analogue scales.	R C Aitken	Proc R Soc Med	1969	4899510	No
2539	2336	1168.0	122.52	61.3	A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain.	M Roland, R Morris	Spine (Phila Pa 1976)	1983	6222486	Yes
2540	1168	1168.0	22.04	22.0	Kinesin and dynein superfamily proteins and the mechanism of organelle transport.	N Hirokawa	Science	1998	9438838	No
2541	1168	1168.0	26.47	26.5	Prediction of protein cellular attributes using pseudo-amino acid composition.	K C Chou	Proteins	2001	11288174	Yes
2542	1167	1167.0	52.72	52.7	Presynaptic regulation of the release of catecholamines.	S Z Langer	Pharmacol Rev	1980	6267618	Yes
2543	1167	1167.0	36.47	36.5	Depression in late life: review and commentary.	Dan G Blazer	J Gerontol A Biol Sci Med Sci	2003	12634292	No
2544	10499	1166.6	358.01	39.8	A novel potent vasoconstrictor peptide produced by vascular endothelial cells.	M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T Masaki	Nature	1988	2451132	Yes
2545	9333	1166.6	244.43	30.6	Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain.	N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M Joliot	Neuroimage	2002	11771995	Yes
2546	3499	1166.3	86.62	28.9	Functional diversity of helper T lymphocytes.	A K Abbas, K M Murphy, A Sher	Nature	1996	8893001	No
2547	1166	1166.0	44.5	44.5	A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes.	S T Tiffany	Psychol Rev	1990	2186423	No
2548	1166	1166.0	26.59	26.6	S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles.	R Donato	Int J Biochem Cell Biol	2001	11390274	No
2549	4664	1166.0	110.12	27.5	A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.	Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry Sharpless	Angew Chem Int Ed Engl	2002	12203546	Yes
2550	1166	1166.0	21.71	21.7	The molecular motor toolbox for intracellular transport.	Ronald D Vale	Cell	2003	12600311	No
2551	1166	1166.0	27.54	27.5	Transcriptional control of adipocyte formation.	Stephen R Farmer	Cell Metab	2006	17011499	No
2552	2331	1165.5	0.0	0.0	The low-density lipoprotein pathway and its relation to atherosclerosis.	J L Goldstein, M S Brown	Annu Rev Biochem	1977	197883	No
2553	3495	1165.0	0.0	0.0	Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.	A DeLean, P J Munson, D Rodbard	Am J Physiol	1978	686171	Yes
2554	1165	1165.0	53.02	53.0	Human agency in social cognitive theory.	A Bandura	Am Psychol	1989	2782727	Yes
2555	1165	1165.0	47.42	47.4	An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results.	J Kabat-Zinn	Gen Hosp Psychiatry	1982	7042457	Yes
2556	1165	1165.0	23.14	23.1	Mobile elements: drivers of genome evolution.	Haig H Kazazian	Science	2004	15016989	No
2557	1165	1165.0	26.92	26.9	Nuclear factor-kappaB: the enemy within.	Bharat B Aggarwal	Cancer Cell	2004	15380510	No
2558	2329	1164.5	95.24	47.6	Rapid procedure for detection and isolation of large and small plasmids.	C I Kado, S T Liu	J Bacteriol	1981	7009583	Yes
2559	5822	1164.4	192.19	38.4	Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity.	D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L Witztum	N Engl J Med	1989	2648148	No
2560	3493	1164.3	105.93	35.3	The functional anatomy of basal ganglia disorders.	R L Albin, A B Young, J B Penney	Trends Neurosci	1989	2479133	No
2561	1164	1164.0	57.37	57.4	Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement.	Virginia A Moyer	Ann Intern Med	2014	24378917	No
2562	4654	1163.5	99.75	24.9	Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.	D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini	Science	2005	15718470	Yes
2563	1163	1163.0	61.72	61.7	Rating scales to assess depression in school-aged children.	M Kovacs	Acta Paedopsychiatr	1981	7025571	Yes
2564	1163	1163.0	22.61	22.6	Histone-deacetylase inhibitors: novel drugs for the treatment of cancer.	Ricky W Johnstone	Nat Rev Drug Discov	2002	12120280	No
2565	2325	1162.5	50.57	25.3	ERBB receptors and cancer: the complexity of targeted inhibitors.	Nancy E Hynes, Heidi A Lane	Nat Rev Cancer	2005	15864276	No
2566	1162	1162.0	49.4	49.4	Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs).	S Safe	Crit Rev Toxicol	1990	2124811	No
2567	2324	1162.0	63.75	31.9	Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications.	M A Pfeffer, E Braunwald	Circulation	1990	2138525	No
2568	3486	1162.0	0.0	0.0	Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels.	A L Shapiro, E Viñuela, J V Maizel	Biochem Biophys Res Commun	1967	4861258	Yes
2569	2324	1162.0	63.99	32.0	A review of central 5-HT receptors and their function.	N M Barnes, T Sharp	Neuropharmacology	1999	10462127	No
2570	1162	1162.0	0.0	0.0	An approximate distribution of estimates of variance components.	F E Satterthwaite	Biometrics	1946	20287815	Yes
2571	3484	1161.3	90.68	30.2	Functional porous coordination polymers.	Susumu Kitagawa, Ryo Kitaura, Shin-ichiro Noro	Angew Chem Int Ed Engl	2004	15114565	Yes
2572	1161	1161.0	0.0	0.0	Mutation selection and the natural history of cancer.	J Cairns	Nature	1975	1143315	Yes
2573	1161	1161.0	0.0	0.0	Diffusion-in-gel methods for immunological analysis. II.	O Ouchterlony	Prog Allergy	1962	14482809	Yes
2574	1159	1159.0	0.0	0.0	Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation.	M M Weiser	J Biol Chem	1973	4698230	Yes
2575	1159	1159.0	19.71	19.7	Themes and variations on ubiquitylation.	A M Weissman	Nat Rev Mol Cell Biol	2001	11265246	No
2576	1159	1159.0	54.68	54.7	Selenium and human health.	Margaret P Rayman	Lancet	2012	22381456	No
2577	1158	1158.0	22.21	22.2	Contingent genetic regulatory events in T lymphocyte activation.	G R Crabtree	Science	1989	2783497	Yes
2578	2315	1157.5	59.54	29.8	Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits.	Kornelia Polyak, Robert A Weinberg	Nat Rev Cancer	2009	19262571	No
2579	1157	1157.0	0.0	0.0	Presynaptic regulation of catecholamine release.	S Z Langer	Biochem Pharmacol	1974	4617579	No
2580	1157	1157.0	27.72	27.7	Liver fibrosis -- from bench to bedside.	Scott L Friedman	J Hepatol	2003	12591185	No
2581	1157	1157.0	28.05	28.1	DNA damage, aging, and cancer.	Jan H J Hoeijmakers	N Engl J Med	2009	19812404	No
2582	2313	1156.5	64.33	32.2	ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins.	Markus Wiederstein, Manfred J Sippl	Nucleic Acids Res	2007	17517781	Yes
2583	3469	1156.3	72.66	24.2	Cellular survival: a play in three Akts.	S R Datta, A Brunet, M E Greenberg	Genes Dev	1999	10579998	No
2584	1156	1156.0	74.15	74.2	Impingement lesions.	C S Neer	Clin Orthop Relat Res	1983	6825348	Yes
2585	2311	1155.5	65.75	32.9	Antibiotic resistance of bacteria in biofilms.	P S Stewart, J W Costerton	Lancet	2001	11463434	No
2586	3466	1155.3	96.9	32.3	Molecular characterization of a peripheral receptor for cannabinoids.	S Munro, K L Thomas, M Abu-Shaar	Nature	1993	7689702	Yes
2587	1155	1155.0	0.0	0.0	Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle.	J O Holloszy	J Biol Chem	1967	4290225	Yes
2588	1155	1155.0	41.07	41.1	Inhibition and facilitation of nucleic acid amplification.	I G Wilson	Appl Environ Microbiol	1997	9327537	No
2589	1155	1155.0	26.78	26.8	Long-term potentiation and memory.	M A Lynch	Physiol Rev	2004	14715912	No
2590	6928	1154.7	135.96	22.7	Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.	S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T Tuschl	Nature	2001	11373684	Yes
2591	2309	1154.5	49.37	24.7	A general framework for weighted gene co-expression network analysis.	Bin Zhang, Steve Horvath	Stat Appl Genet Mol Biol	2005	16646834	Yes
2592	1154	1154.0	53.46	53.5	Biomaterial-centered infection: microbial adhesion versus tissue integration.	A G Gristina	Science	1987	3629258	Yes
2593	2308	1154.0	0.0	0.0	Plasminogen: purification from human plasma by affinity chromatography.	D G Deutsch, E T Mertz	Science	1970	5475635	Yes
2594	1154	1154.0	0.0	0.0	RNA metabolism in the HeLa cell nucleus.	S Penman	J Mol Biol	1966	5961144	Yes
2595	2306	1153.0	45.45	22.7	Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.	C W Greider, E H Blackburn	Cell	1985	3907856	Yes
2596	1153	1153.0	45.16	45.2	Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes.	H V Gelboin	Physiol Rev	1980	7001511	No
2597	1153	1153.0	53.75	53.8	Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters.	P de Leva	J Biomech	1996	8872282	Yes
2598	1153	1153.0	33.93	33.9	Varieties of impulsivity.	J L Evenden	Psychopharmacology (Berl)	1999	10550486	No
2599	1153	1153.0	27.72	27.7	The Unified Medical Language System (UMLS): integrating biomedical terminology.	Olivier Bodenreider	Nucleic Acids Res	2004	14681409	Yes
2600	5764	1152.8	112.32	22.5	Crystal structure of the nucleosome core particle at 2.8 A resolution.	K Luger, A W Mäder, R K Richmond, D F Sargent, T J Richmond	Nature	1997	9305837	Yes
2601	6915	1152.5	177.16	29.5	Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.	Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O Lötvall	Nat Cell Biol	2007	17486113	Yes
2602	2305	1152.5	61.64	30.8	Regulation mechanisms and signaling pathways of autophagy.	Congcong He, Daniel J Klionsky	Annu Rev Genet	2009	19653858	No
2603	3457	1152.3	0.0	0.0	High resolution two-dimensional electrophoresis of basic as well as acidic proteins.	P Z O'Farrell, H M Goodman, P H O'Farrell	Cell	1977	23215	Yes
2604	1152	1152.0	53.37	53.4	Derivation and validation of a short-form oral health impact profile.	G D Slade	Community Dent Oral Epidemiol	1997	9332805	Yes
2605	2304	1152.0	47.7	23.9	Molecular chaperones in the cytosol: from nascent chain to folded protein.	F Ulrich Hartl, Manajit Hayer-Hartl	Science	2002	11884745	No
2606	2303	1151.5	0.0	0.0	Quantitative determination of serum triglycerides by the use of enzymes.	G Bucolo, H David	Clin Chem	1973	4703655	Yes
2607	2303	1151.5	50.19	25.1	Tumorigenesis and the angiogenic switch.	Gabriele Bergers, Laura E Benjamin	Nat Rev Cancer	2003	12778130	No
2608	3454	1151.3	94.03	31.3	Membrane lipids: where they are and how they behave.	Gerrit van Meer, Dennis R Voelker, Gerald W Feigenson	Nat Rev Mol Cell Biol	2008	18216768	No
2609	1151	1151.0	0.0	0.0	Selective coronary arteriography. I. A percutaneous transfemoral technic.	M P Judkins	Radiology	1967	6048074	Yes
2610	1151	1151.0	59.14	59.1	The clinical application of the biopsychosocial model.	G L Engel	Am J Psychiatry	1980	7369396	Yes
2611	2302	1151.0	51.42	25.7	Lymphocyte homing and homeostasis.	E C Butcher, L J Picker	Science	1996	8600538	No
2612	1151	1151.0	28.11	28.1	Matrix proteoglycans: from molecular design to cellular function.	R V Iozzo	Annu Rev Biochem	1998	9759499	No
2613	1151	1151.0	23.37	23.4	Lipid rafts: elusive or illusive?	Sean Munro	Cell	2003	14622593	No
2614	1151	1151.0	33.29	33.3	The sympathetic control of blood pressure.	Patrice G Guyenet	Nat Rev Neurosci	2006	16760914	No
2615	2301	1150.5	62.86	31.4	Imaging cognition II: An empirical review of 275 PET and fMRI studies.	R Cabeza, L Nyberg	J Cogn Neurosci	2000	10769304	No
2616	3451	1150.3	0.0	0.0	The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects.	G Blessed, B E Tomlinson, M Roth	Br J Psychiatry	1968	5662937	Yes
2617	1150	1150.0	0.0	0.0	A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations.	R D Hotchkiss	Arch Biochem	1948	18921848	Yes
2618	3449	1149.7	75.25	25.1	Calcium signalling: dynamics, homeostasis and remodelling.	Michael J Berridge, Martin D Bootman, H Llewelyn Roderick	Nat Rev Mol Cell Biol	2003	12838335	No
2619	1149	1149.0	30.75	30.8	Pathogenesis of dengue: challenges to molecular biology.	S B Halstead	Science	1988	3277268	No
2620	1149	1149.0	31.15	31.1	The lipocalin protein family: structure and function.	D R Flower	Biochem J	1996	8761444	No
2621	1148	1148.0	25.9	25.9	Cadherins: a molecular family important in selective cell-cell adhesion.	M Takeichi	Annu Rev Biochem	1990	2197976	No
2622	1147	1147.0	0.0	0.0	Biogenic amines and the states of sleep.	M Jouvet	Science	1969	4303225	No
2623	3441	1147.0	88.55	29.5	LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions.	A C Wallace, R A Laskowski, J M Thornton	Protein Eng	1995	7630882	Yes
2624	1147	1147.0	30.13	30.1	Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.	G Boden	Diabetes	1997	8971073	No
2625	1147	1147.0	29.37	29.4	Optimal experimental design for event-related fMRI.	A M Dale	Hum Brain Mapp	1999	10524601	Yes
2626	2292	1146.0	69.84	34.9	Recent advances in the phencyclidine model of schizophrenia.	D C Javitt, S R Zukin	Am J Psychiatry	1991	1654746	No
2627	1146	1146.0	45.42	45.4	Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living.	S Katz	J Am Geriatr Soc	1983	6418786	No
2628	1146	1146.0	26.7	26.7	Diarylethenes for Memories and Switches.	Masahiro Irie	Chem Rev	2000	11777416	Yes
2629	1145	1145.0	0.0	0.0	Radioimmunological determination of human C-peptide in serum.	L G Heding	Diabetologia	1975	1239396	Yes
2630	1145	1145.0	21.04	21.0	Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes.	D Hanahan	Nature	1985	2986015	Yes
2631	1145	1145.0	30.79	30.8	Psychological and neural mechanisms of the affective dimension of pain.	D D Price	Science	2000	10846154	No
2632	18305	1144.1	693.66	43.4	Fiji: an open-source platform for biological-image analysis.	Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert Cardona	Nat Methods	2012	22743772	Yes
2633	1144	1144.0	0.0	0.0	Experience from a multicentre stroke register: a preliminary report.	S Hatano	Bull World Health Organ	1976	1088404	Yes
2634	1144	1144.0	0.0	0.0	Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol.	D B Clewell	J Bacteriol	1972	4336693	Yes
2635	1144	1144.0	32.39	32.4	DNA topoisomerases.	M Gellert	Annu Rev Biochem	1981	6267993	No
2636	1144	1144.0	33.44	33.4	Papillary and follicular thyroid carcinoma.	M J Schlumberger	N Engl J Med	1998	9445411	No
2637	1144	1144.0	38.29	38.3	The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases.	Artemis P Simopoulos	Exp Biol Med (Maywood)	2008	18408140	No
2638	3431	1143.7	89.98	30.0	Atomic force microscope.	Binnig, Quate, Gerber	Phys Rev Lett	1986	10033323	Yes
2639	2287	1143.5	0.0	0.0	Growth of a rat neuroblastoma cell line in serum-free supplemented medium.	J E Bottenstein, G H Sato	Proc Natl Acad Sci U S A	1979	284369	Yes
2640	2287	1143.5	0.0	0.0	Solubilization of membranes by detergents.	A Helenius, K Simons	Biochim Biophys Acta	1975	1091302	No
2641	2286	1143.0	46.7	23.4	A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells.	N C Andrews, D V Faller	Nucleic Acids Res	1991	2041787	Yes
2642	1143	1143.0	28.05	28.1	Pathways of oxidative damage.	James A Imlay	Annu Rev Microbiol	2003	14527285	No
2643	2286	1143.0	62.07	31.0	Myocardial reperfusion injury.	Derek M Yellon, Derek J Hausenloy	N Engl J Med	2007	17855673	No
2644	2286	1143.0	60.94	30.5	Microglia: active sensor and versatile effector cells in the normal and pathologic brain.	Uwe-Karsten Hanisch, Helmut Kettenmann	Nat Neurosci	2007	17965659	No
2645	2285	1142.5	89.5	44.8	Malondialdehyde determination as index of lipid peroxidation.	H H Draper, M Hadley	Methods Enzymol	1990	2233309	Yes
2646	3427	1142.3	0.0	0.0	Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.	G M Wahl, M Stern, G R Stark	Proc Natl Acad Sci U S A	1979	291033	Yes
2647	1142	1142.0	25.01	25.0	Platelets in atherothrombosis.	Zaverio M Ruggeri	Nat Med	2002	12411949	No
2648	2284	1142.0	54.38	27.2	Can the pharmaceutical industry reduce attrition rates?	Ismail Kola, John Landis	Nat Rev Drug Discov	2004	15286737	No
2649	3425	1141.7	80.53	26.8	OrthoMCL: identification of ortholog groups for eukaryotic genomes.	Li Li, Christian J Stoeckert, David S Roos	Genome Res	2003	12952885	Yes
2650	1141	1141.0	0.0	0.0	The concept of immunological surveillance.	F M Burnet	Prog Exp Tumor Res	1970	4921480	No
2651	1141	1141.0	0.0	0.0	A simple objective technique for measuring flexibility in thinking.	E A Berg	J Gen Psychol	1948	18889466	Yes
2652	1140	1140.0	37.13	37.1	Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology.	J J Gross	J Pers Soc Psychol	1998	9457784	Yes
2653	1140	1140.0	29.14	29.1	Primate anterior cingulate cortex: where motor control, drive and cognition interface.	T Paus	Nat Rev Neurosci	2001	11389475	No
2654	1140	1140.0	26.28	26.3	Gene finding in novel genomes.	Ian Korf	BMC Bioinformatics	2004	15144565	Yes
2655	1140	1140.0	0.0	0.0	pA, a new scale for the measurement of drug antagonism.	H O Schild	Br J Pharmacol Chemother	1947	20258355	Yes
2656	1139	1139.0	27.73	27.7	Rapid and sensitive sequence comparison with FASTP and FASTA.	W R Pearson	Methods Enzymol	1990	2156132	Yes
2657	1139	1139.0	31.63	31.6	Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena.	U Mitzdorf	Physiol Rev	1985	3880898	No
2658	3415	1138.3	75.14	25.0	Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM).	Michael J Rust, Mark Bates, Xiaowei Zhuang	Nat Methods	2006	16896339	Yes
2659	4553	1138.2	100.58	25.1	Interleukin-10 and the interleukin-10 receptor.	K W Moore, R de Waal Malefyt, R L Coffman, A O'Garra	Annu Rev Immunol	2001	11244051	No
2660	4553	1138.2	276.66	69.2	IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies.	Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang Minh	Mol Biol Evol	2015	25371430	Yes
2661	2276	1138.0	95.98	48.0	Reading senseless sentences: brain potentials reflect semantic incongruity.	M Kutas, S A Hillyard	Science	1980	7350657	Yes
2662	1138	1138.0	0.0	0.0	Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase.	R J Pennington	Biochem J	1961	13734134	Yes
2663	3412	1137.3	0.0	0.0	Cytochemical identification of monocytes and granulocytes.	L T Yam, C Y Li, W H Crosby	Am J Clin Pathol	1971	5549896	Yes
2664	3412	1137.3	91.05	30.3	Wnt/beta-catenin signaling: components, mechanisms, and diseases.	Bryan T MacDonald, Keiko Tamai, Xi He	Dev Cell	2009	19619488	No
2665	1137	1137.0	0.0	0.0	Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release.	S Z Langer	Br J Pharmacol	1977	20190	No
2666	1137	1137.0	34.41	34.4	Effect of anoxia on ion distribution in the brain.	A J Hansen	Physiol Rev	1985	3880896	No
2667	1137	1137.0	0.0	0.0	Pathologic anatomy of the pancreas in juvenile diabetes mellitus.	W Gepts	Diabetes	1965	5318831	Yes
2668	1137	1137.0	26.22	26.2	Translating cell biology into therapeutic advances in Alzheimer's disease.	D J Selkoe	Nature	1999	10392577	No
2669	1137	1137.0	32.07	32.1	The biochemistry and medical significance of the flavonoids.	Bent H Havsteen	Pharmacol Ther	2002	12453566	No
2670	1137	1137.0	0.0	0.0	Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells.	A B Stavitsky	J Immunol	1954	13163409	Yes
2671	2274	1137.0	64.83	32.4	Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.	Ajay Kumar Gupta, Mona Gupta	Biomaterials	2005	15626447	No
2672	1136	1136.0	0.0	0.0	An improved fluorometric assay for DNA.	R T Hinegardner	Anal Biochem	1971	5544593	Yes
2673	1136	1136.0	28.89	28.9	Huntington's disease.	Francis O Walker	Lancet	2007	17240289	No
2674	2271	1135.5	156.86	78.4	Facial nerve grading system.	J W House, D E Brackmann	Otolaryngol Head Neck Surg	1985	3921901	Yes
2675	2271	1135.5	49.75	24.9	Functions of lipid rafts in biological membranes.	D A Brown, E London	Annu Rev Cell Dev Biol	1998	9891780	No
2676	1135	1135.0	26.83	26.8	Mitochondrial transport of cations: channels, exchangers, and permeability transition.	P Bernardi	Physiol Rev	1999	10508231	No
2677	2270	1135.0	78.75	39.4	Quality control and preprocessing of metagenomic datasets.	Robert Schmieder, Robert Edwards	Bioinformatics	2011	21278185	Yes
2678	2269	1134.5	71.29	35.6	Role of oxidized low density lipoprotein in atherogenesis.	J L Witztum, D Steinberg	J Clin Invest	1991	1752940	No
2679	2269	1134.5	59.14	29.6	Drug delivery systems: entering the mainstream.	Theresa M Allen, Pieter R Cullis	Science	2004	15031496	Yes
2680	1134	1134.0	35.78	35.8	Chronic disease management: what will it take to improve care for chronic illness?	E H Wagner	Eff Clin Pract	1998	10345255	No
2681	1133	1133.0	0.0	0.0	Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone.	A R Midgley	Endocrinology	1966	5950482	Yes
2682	1133	1133.0	25.77	25.8	Molecular physiology of low-voltage-activated t-type calcium channels.	Edward Perez-Reyes	Physiol Rev	2003	12506128	No
2683	2266	1133.0	59.89	29.9	Microenvironmental regulation of metastasis.	Johanna A Joyce, Jeffrey W Pollard	Nat Rev Cancer	2009	19279573	No
2684	1132	1132.0	19.77	19.8	Mitotic kinases as regulators of cell division and its checkpoints.	E A Nigg	Nat Rev Mol Cell Biol	2001	11413462	No
2685	1132	1132.0	37.96	38.0	Interleukin-1 in the pathogenesis and treatment of inflammatory diseases.	Charles A Dinarello	Blood	2011	21304099	No
2686	2263	1131.5	61.83	30.9	Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.	R A Ignotz, J Massagué	J Biol Chem	1986	3456347	Yes
2687	2263	1131.5	96.78	48.4	Van der Waals heterostructures.	A K Geim, I V Grigorieva	Nature	2013	23887427	Yes
2688	1131	1131.0	20.6	20.6	Stem cells: units of development, units of regeneration, and units in evolution.	I L Weissman	Cell	2000	10647940	No
2689	1130	1130.0	28.77	28.8	Two distinct classes of carbohydrate-recognition domains in animal lectins.	K Drickamer	J Biol Chem	1988	3290208	No
2690	1130	1130.0	43.41	43.4	On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture.	D Collen	Thromb Haemost	1980	6450468	No
2691	1130	1130.0	22.35	22.4	Mechanisms and consequences of activation of protein kinase B/Akt.	J Downward	Curr Opin Cell Biol	1998	9561851	No
2692	2260	1130.0	62.21	31.1	Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients.	S Schulman, C Kearon	J Thromb Haemost	2005	15842354	Yes
2693	1130	1130.0	25.27	25.3	The roles of intracellular protein-degradation pathways in neurodegeneration.	David C Rubinsztein	Nature	2006	17051204	No
2694	1129	1129.0	35.48	35.5	Protein damage and degradation by oxygen radicals. I. general aspects.	K J Davies	J Biol Chem	1987	3036875	Yes
2695	2258	1129.0	66.11	33.1	Increasing incidence of thyroid cancer in the United States, 1973-2002.	Louise Davies, H Gilbert Welch	JAMA	2006	16684987	Yes
2696	3384	1128.0	68.86	23.0	Predicting coiled coils from protein sequences.	A Lupas, M Van Dyke, J Stock	Science	1991	2031185	Yes
2697	1128	1128.0	23.37	23.4	IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors.	Yong-Jun Liu	Annu Rev Immunol	2005	15771572	No
2698	1127	1127.0	0.0	0.0	Optimal foraging, the marginal value theorem.	E L Charnov	Theor Popul Biol	1976	1273796	Yes
2699	1127	1127.0	26.86	26.9	Brain tumors.	L M DeAngelis	N Engl J Med	2001	11150363	No
2700	3381	1127.0	101.38	33.8	Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles.	Günter Oberdörster, Eva Oberdörster, Jan Oberdörster	Environ Health Perspect	2005	16002369	No
2701	1127	1127.0	0.0	0.0	The generalisation of student's problems when several different population variances are involved.	B L Welch	Biometrika	1947	20287819	Yes
2702	2253	1126.5	0.0	0.0	Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses.	R B Gustilo, J T Anderson	J Bone Joint Surg Am	1976	773941	Yes
2703	2253	1126.5	48.47	24.2	Toll-like receptors in the induction of the innate immune response.	A Aderem, R J Ulevitch	Nature	2000	10963608	No
2704	3379	1126.3	85.14	28.4	Tissue cells feel and respond to the stiffness of their substrate.	Dennis E Discher, Paul Janmey, Yu-Li Wang	Science	2005	16293750	No
2705	4505	1126.2	112.39	28.1	Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites.	H Nielsen, J Engelbrecht, S Brunak, G von Heijne	Protein Eng	1997	9051728	Yes
2706	1126	1126.0	28.92	28.9	Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.	I J Fidler	Cancer Res	1990	1698118	Yes
2707	1126	1126.0	33.95	34.0	Unstable angina. A classification.	E Braunwald	Circulation	1989	2752565	Yes
2708	1126	1126.0	40.98	41.0	Plasma perspective on strong field multiphoton ionization.	Corkum	Phys Rev Lett	1993	10054556	Yes
2709	1126	1126.0	44.39	44.4	Translating social ecological theory into guidelines for community health promotion.	D Stokols	Am J Health Promot	1996	10159709	No
2710	1126	1126.0	30.66	30.7	Pain and emotion interactions in subregions of the cingulate gyrus.	Brent A Vogt	Nat Rev Neurosci	2005	15995724	No
2711	1126	1126.0	32.35	32.4	How brains beware: neural mechanisms of emotional attention.	Patrik Vuilleumier	Trends Cogn Sci	2005	16289871	Yes
2712	2251	1125.5	51.22	25.6	The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications.	P M Sharp, W H Li	Nucleic Acids Res	1987	3547335	Yes
2713	1125	1125.0	36.44	36.4	Molecular biology of steroid hormone synthesis.	W L Miller	Endocr Rev	1988	3061784	No
2714	2250	1125.0	0.0	0.0	Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice.	J D McGhee, P H von Hippel	J Mol Biol	1974	4416620	Yes
2715	1125	1125.0	24.51	24.5	Stem cells in the central nervous system.	R McKay	Science	1997	9082987	No
2716	1125	1125.0	37.0	37.0	Endometriosis.	Serdar E Bulun	N Engl J Med	2009	19144942	No
2717	3374	1124.7	99.9	33.3	Nitric oxide and peroxynitrite in health and disease.	Pál Pacher, Joseph S Beckman, Lucas Liaudet	Physiol Rev	2007	17237348	No
2718	4498	1124.5	124.81	31.2	Microbial ecology: human gut microbes associated with obesity.	Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I Gordon	Nature	2006	17183309	Yes
2719	2248	1124.0	0.0	0.0	Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases.	L M Siegel, K J Monty	Biochim Biophys Acta	1966	5329026	Yes
2720	1124	1124.0	34.88	34.9	Low-molecular-weight heparins.	J I Weitz	N Engl J Med	1997	9278467	No
2721	2248	1124.0	80.81	40.4	Oncology meets immunology: the cancer-immunity cycle.	Daniel S Chen, Ira Mellman	Immunity	2013	23890059	No
2722	2247	1123.5	0.0	0.0	Radiological demarcation of cemented sockets in total hip replacement.	J G DeLee, J Charnley	Clin Orthop Relat Res	1976	991504	Yes
2723	2247	1123.5	61.12	30.6	Analysis of gene control signals by DNA fusion and cloning in Escherichia coli.	M J Casadaban, S N Cohen	J Mol Biol	1980	6997493	Yes
2724	1123	1123.0	33.93	33.9	Determinants of tumor blood flow: a review.	R K Jain	Cancer Res	1988	3282647	No
2725	1123	1123.0	30.31	30.3	The chromosomal basis of human neoplasia.	J J Yunis	Science	1983	6336310	Yes
2726	1123	1123.0	22.45	22.4	Regulation of transcription by MAP kinase cascades.	R Treisman	Curr Opin Cell Biol	1996	8791420	No
2727	1123	1123.0	27.24	27.2	Metastatic bone disease: clinical features, pathophysiology and treatment strategies.	R E Coleman	Cancer Treat Rev	2001	11417967	No
2728	2245	1122.5	43.94	22.0	Multiple nuclear factors interact with the immunoglobulin enhancer sequences.	R Sen, D Baltimore	Cell	1986	3091258	Yes
2729	2245	1122.5	66.45	33.2	Excitatory amino acids as a final common pathway for neurologic disorders.	S A Lipton, P A Rosenberg	N Engl J Med	1994	7905600	No
2730	1122	1122.0	0.0	0.0	An approach for the treatment of penile carcinoma.	R M Cabanas	Cancer	1977	837331	Yes
2731	1122	1122.0	32.02	32.0	The induction of pain: an integrative review.	M J Millan	Prog Neurobiol	1999	9987804	No
2732	1122	1122.0	31.29	31.3	Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence.	Earl S Ford	Diabetes Care	2005	15983333	No
2733	2243	1121.5	91.76	45.9	The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure.	R Näätänen, T Picton	Psychophysiology	1987	3615753	Yes
2734	2243	1121.5	0.0	0.0	Active transport of sodium as the source of electric current in the short-circuited isolated frog skin.	H H Ussing, K Zerahn	Acta Physiol Scand	1951	14868510	Yes
2735	1121	1121.0	39.63	39.6	Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds.	A J Alpert	J Chromatogr	1990	2324207	Yes
2736	1121	1121.0	78.62	78.6	The problem of rigor in qualitative research.	M Sandelowski	ANS Adv Nurs Sci	1986	3083765	Yes
2737	3363	1121.0	72.43	24.1	Toll-like receptors: critical proteins linking innate and acquired immunity.	S Akira, K Takeda, T Kaisho	Nat Immunol	2001	11477402	No
2738	3363	1121.0	124.74	41.6	Rehospitalizations among patients in the Medicare fee-for-service program.	Stephen F Jencks, Mark V Williams, Eric A Coleman	N Engl J Med	2009	19339721	Yes
2739	2240	1120.0	75.82	37.9	Atomic structure and chemistry of human serum albumin.	X M He, D C Carter	Nature	1992	1630489	Yes
2740	1120	1120.0	40.78	40.8	Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes.	W A Catterall	Annu Rev Pharmacol Toxicol	1980	6247957	No
2741	1120	1120.0	26.77	26.8	Amyloid, the presenilins and Alzheimer's disease.	J Hardy	Trends Neurosci	1997	9106355	No
2742	1120	1120.0	0.0	0.0	On the law of effect.	R J Herrnstein	J Exp Anal Behav	1970	16811440	Yes
2743	1120	1120.0	25.42	25.4	Solving structures of protein complexes by molecular replacement with Phaser.	Airlie J McCoy	Acta Crystallogr D Biol Crystallogr	2007	17164524	Yes
2744	3360	1120.0	107.62	35.9	Dose translation from animal to human studies revisited.	Shannon Reagan-Shaw, Minakshi Nihal, Nihal Ahmad	FASEB J	2008	17942826	Yes
2745	4479	1119.8	108.38	27.1	Base-calling of automated sequencer traces using phred. I. Accuracy assessment.	B Ewing, L Hillier, M C Wendl, P Green	Genome Res	1998	9521921	Yes
2746	2239	1119.5	63.63	31.8	Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.	R G Phillips, J E LeDoux	Behav Neurosci	1992	1590953	Yes
2747	2239	1119.5	65.93	33.0	Alternative activation of macrophages: mechanism and functions.	Siamon Gordon, Fernando O Martinez	Immunity	2010	20510870	No
2748	4477	1119.2	132.17	33.0	Place navigation impaired in rats with hippocampal lesions.	R G Morris, P Garrud, J N Rawlins, J O'Keefe	Nature	1982	7088155	Yes
2749	1119	1119.0	35.18	35.2	Energy contributions of volatile fatty acids from the gastrointestinal tract in various species.	E N Bergman	Physiol Rev	1990	2181501	No
2750	1119	1119.0	33.04	33.0	Cell surface interactions with extracellular materials.	K M Yamada	Annu Rev Biochem	1983	6351729	No
2751	1119	1119.0	30.84	30.8	Polymer conjugates as anticancer nanomedicines.	Ruth Duncan	Nat Rev Cancer	2006	16900224	No
2752	2238	1119.0	62.9	31.4	Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments.	Gerard Talavera, Jose Castresana	Syst Biol	2007	17654362	Yes
2753	1119	1119.0	28.77	28.8	Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science.	Christof M Niemeyer	Angew Chem Int Ed Engl	2001	29712109	No
2754	2237	1118.5	0.0	0.0	Construct validity in psychological tests.	L J Cronbach, P E Meehl	Psychol Bull	1955	13245896	Yes
2755	3354	1118.0	69.4	23.1	The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.	Fabio Martinon, Kimberly Burns, Jürg Tschopp	Mol Cell	2002	12191486	Yes
2756	4469	1117.2	105.22	26.3	SCOP: a structural classification of proteins database for the investigation of sequences and structures.	A G Murzin, S E Brenner, T Hubbard, C Chothia	J Mol Biol	1995	7723011	Yes
2757	1117	1117.0	30.98	31.0	Diseases of the mitochondrial DNA.	D C Wallace	Annu Rev Biochem	1992	1497308	No
2758	1117	1117.0	31.39	31.4	Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics.	G L Semenza	Oncogene	2010	19946328	No
2759	3350	1116.7	87.48	29.2	Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya.	C R Woese, O Kandler, M L Wheelis	Proc Natl Acad Sci U S A	1990	2112744	Yes
2760	4464	1116.0	101.84	25.5	Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.	J E Walker, M Saraste, M J Runswick, N J Gay	EMBO J	1982	6329717	Yes
2761	1116	1116.0	26.66	26.7	Allelic discrimination using fluorogenic probes and the 5' nuclease assay.	K J Livak	Genet Anal	1999	10084106	Yes
2762	12260	1114.5	443.15	40.3	A new equation to estimate glomerular filtration rate.	Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef Coresh	Ann Intern Med	2009	19414839	Yes
2763	1114	1114.0	23.8	23.8	Mutator phenotype may be required for multistage carcinogenesis.	L A Loeb	Cancer Res	1991	2039987	No
2764	1114	1114.0	0.0	0.0	Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb.	J Altman	J Comp Neurol	1969	5361244	Yes
2765	2227	1113.5	66.9	33.5	Nitric oxide synthases in mammals.	R G Knowles, S Moncada	Biochem J	1994	7510950	No
2766	1113	1113.0	33.99	34.0	The structure of common mental disorders.	R F Krueger	Arch Gen Psychiatry	1999	10530634	Yes
2767	1113	1113.0	33.66	33.7	Reducing children's television viewing to prevent obesity: a randomized controlled trial.	T N Robinson	JAMA	1999	10546696	Yes
2768	2225	1112.5	61.84	30.9	Neural systems of reinforcement for drug addiction: from actions to habits to compulsion.	Barry J Everitt, Trevor W Robbins	Nat Neurosci	2005	16251991	No
2769	2225	1112.5	91.66	45.8	Neutrophil recruitment and function in health and inflammation.	Elzbieta Kolaczkowska, Paul Kubes	Nat Rev Immunol	2013	23435331	No
2770	1112	1112.0	0.0	0.0	Cytoprotection by prostaglandins.	A Robert	Gastroenterology	1979	38173	Yes
2771	1112	1112.0	0.0	0.0	Metabolic stability and epigenesis in randomly constructed genetic nets.	S A Kauffman	J Theor Biol	1969	5803332	Yes
2772	3336	1112.0	78.26	26.1	Hepatocellular carcinoma.	Josep M Llovet, Andrew Burroughs, Jordi Bruix	Lancet	2003	14667750	No
2773	1111	1111.0	0.0	0.0	6-Hydroxy-dopamine induced degeneration of central monoamine neurons.	U Ungerstedt	Eur J Pharmacol	1968	5718510	Yes
2774	1111	1111.0	0.0	0.0	Studies on histones. 7. Preparative methods for histone fractions from calf thymus.	E W Johns	Biochem J	1964	5840387	Yes
2775	1111	1111.0	36.3	36.3	Risk and maintenance factors for eating pathology: a meta-analytic review.	Eric Stice	Psychol Bull	2002	12206196	No
2776	1111	1111.0	23.48	23.5	Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy.	Harold F Dvorak	J Clin Oncol	2002	12409337	No
2777	1111	1111.0	30.59	30.6	Hydrogen sulphide and its therapeutic potential.	Csaba Szabó	Nat Rev Drug Discov	2007	17948022	No
2778	1111	1111.0	25.58	25.6	Neuroligins and neurexins link synaptic function to cognitive disease.	Thomas C Südhof	Nature	2008	18923512	No
2779	1110	1110.0	30.14	30.1	Wound healing and its impairment in the diabetic foot.	Vincent Falanga	Lancet	2005	16291068	No
2780	1110	1110.0	31.4	31.4	Plant productivity and environment.	J S Boyer	Science	1982	17808529	Yes
2781	2220	1110.0	108.3	54.1	ROS function in redox signaling and oxidative stress.	Michael Schieber, Navdeep S Chandel	Curr Biol	2014	24845678	No
2782	1109	1109.0	28.87	28.9	Linkage strategies for genetically complex traits. I. Multilocus models.	N Risch	Am J Hum Genet	1990	2301392	Yes
2783	1109	1109.0	25.46	25.5	Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes.	M Kozak	Nucleic Acids Res	1981	7301588	Yes
2784	2218	1109.0	44.33	22.2	NF-kappaB at the crossroads of life and death.	Michael Karin, Anning Lin	Nat Immunol	2002	11875461	No
2785	1109	1109.0	25.21	25.2	Microglia as a source and target of cytokines.	Uwe-Karsten Hanisch	Glia	2002	12379902	No
2786	2218	1109.0	0.0	0.0	Micromethod for the direct determination of serum triglycerides.	E Van Handel, D B Zilversmit	J Lab Clin Med	1957	13439279	Yes
2787	1109	1109.0	0.0	0.0	The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis.	R E Hope-Simpson	Proc R Soc Med	1965	14267505	Yes
2788	2218	1109.0	51.04	25.5	Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms.	Eugenia E Calle, Rudolf Kaaks	Nat Rev Cancer	2004	15286738	No
2789	1109	1109.0	35.54	35.5	Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.	Felix Kratz	J Control Release	2008	18582981	No
2790	6653	1108.8	179.64	29.9	Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research.	Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat Robles	Bioinformatics	2005	16081474	Yes
2791	1108	1108.0	21.18	21.2	Luciferase reporter gene vectors for analysis of promoters and enhancers.	S K Nordeen	Biotechniques	1988	2908509	Yes
2792	1108	1108.0	26.77	26.8	Production of recombinant protein therapeutics in cultivated mammalian cells.	Florian M Wurm	Nat Biotechnol	2004	15529164	No
2793	1108	1108.0	34.89	34.9	Cytokinesis-block micronucleus cytome assay.	Michael Fenech	Nat Protoc	2007	17546000	Yes
2794	2213	1106.5	48.15	24.1	Atherosclerosis. the road ahead.	C K Glass, J L Witztum	Cell	2001	11239408	No
2795	1106	1106.0	0.0	0.0	Structure of chromatin.	R D Kornberg	Annu Rev Biochem	1977	332067	No
2796	1106	1106.0	26.68	26.7	The prefrontal cortex and cognitive control.	E K Miller	Nat Rev Neurosci	2000	11252769	No
2797	2211	1105.5	49.22	24.6	Prediction of protein secondary structure at better than 70% accuracy.	B Rost, C Sander	J Mol Biol	1993	8345525	Yes
2798	1105	1105.0	35.47	35.5	Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate.	J E Oesterling	J Urol	1991	1707989	No
2799	1105	1105.0	40.07	40.1	The LMS method for constructing normalized growth standards.	T J Cole	Eur J Clin Nutr	1990	2354692	Yes
2800	2210	1105.0	41.17	20.6	Stats: transcriptional control and biological impact.	David E Levy, J E Darnell	Nat Rev Mol Cell Biol	2002	12209125	No
2801	1105	1105.0	0.0	0.0	Voluntary strength and fatigue.	P A Merton	J Physiol	1954	13152698	Yes
2802	1105	1105.0	0.0	0.0	Preliminary Trial Of Carisoprodol In Multiple Sclerosis.	B Ashworth	Practitioner	1964	14143329	Yes
2803	2210	1105.0	52.06	26.0	Toll-like receptors in innate immunity.	Kiyoshi Takeda, Shizuo Akira	Int Immunol	2005	15585605	No
2804	2209	1104.5	141.39	70.7	A joint coordinate system for the clinical description of three-dimensional motions: application to the knee.	E S Grood, W J Suntay	J Biomech Eng	1983	6865355	Yes
2805	2209	1104.5	0.0	0.0	Microdroplet Assay Of Human Serum Cytotoxins.	P I Terasaki, J D Mcclelland	Nature	1964	14248725	Yes
2806	2209	1104.5	0.0	0.0	A revision of the Schoenheimer-Sperry method for cholesterol determination.	W M Sperry, M Webb	J Biol Chem	1950	14794694	Yes
2807	1104	1104.0	31.25	31.2	Normalization of cell responses in cat striate cortex.	D J Heeger	Vis Neurosci	1992	1504027	Yes
2808	1104	1104.0	31.0	31.0	Neural simulation of action: a unifying mechanism for motor cognition.	M Jeannerod	Neuroimage	2001	11373140	No
2809	2207	1103.5	43.82	21.9	Homeobox genes and axial patterning.	W McGinnis, R Krumlauf	Cell	1992	1346368	No
2810	1103	1103.0	23.59	23.6	ALSCRIPT: a tool to format multiple sequence alignments.	G J Barton	Protein Eng	1993	8433969	Yes
2811	2206	1103.0	72.83	36.4	An estimate of the worldwide prevalence and disability associated with osteoporotic fractures.	O Johnell, J A Kanis	Osteoporos Int	2006	16983459	Yes
2812	2205	1102.5	67.74	33.9	A cognitive model of posttraumatic stress disorder.	A Ehlers, D M Clark	Behav Res Ther	2000	10761279	No
2813	1102	1102.0	37.69	37.7	Chemoprevention of cancer.	L W Wattenberg	Cancer Res	1985	3880665	No
2814	1102	1102.0	24.94	24.9	Physiological concentrations of purines and pyrimidines.	T W Traut	Mol Cell Biochem	1994	7877593	No
2815	1102	1102.0	22.01	22.0	Microarray data normalization and transformation.	John Quackenbush	Nat Genet	2002	12454644	No
2816	7714	1102.0	288.35	41.2	GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.	Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J Schünemann	BMJ	2008	18436948	Yes
2817	1101	1101.0	43.45	43.5	Molecular aspects of ligand binding to serum albumin.	U Kragh-Hansen	Pharmacol Rev	1981	7027277	No
2818	1101	1101.0	0.0	0.0	The powerful placebo.	H K Beecher	J Am Med Assoc	1955	13271123	Yes
2819	1101	1101.0	30.45	30.4	Q-ball imaging.	David S Tuch	Magn Reson Med	2004	15562495	Yes
2820	1101	1101.0	25.79	25.8	Recognition and processing of ubiquitin-protein conjugates by the proteasome.	Daniel Finley	Annu Rev Biochem	2009	19489727	No
2821	7704	1100.6	258.13	36.9	AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility.	Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J Olson	J Comput Chem	2009	19399780	Yes
2822	2201	1100.5	45.85	22.9	Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133.	G A Gonzalez, M R Montminy	Cell	1989	2573431	Yes
2823	3301	1100.3	0.0	0.0	Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.	M Hamberg, J Svensson, B Samuelsson	Proc Natl Acad Sci U S A	1975	1059088	Yes
2824	1100	1100.0	0.0	0.0	Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units.	C M Venkatachalam	Biopolymers	1968	5685102	Yes
2825	1100	1100.0	27.6	27.6	Metabolism and functions of glutathione in brain.	R Dringen	Prog Neurobiol	2000	10880854	No
2826	1100	1100.0	25.67	25.7	Neurobiology of Pavlovian fear conditioning.	S Maren	Annu Rev Neurosci	2001	11520922	No
2827	1100	1100.0	36.76	36.8	Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations.	Ronald A Hites	Environ Sci Technol	2004	14998004	Yes
2828	2199	1099.5	64.46	32.2	The cognitive control of emotion.	Kevin N Ochsner, James J Gross	Trends Cogn Sci	2005	15866151	No
2829	2198	1099.0	0.0	0.0	Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms.	R J Britten, D E Kohne	Science	1968	4874239	Yes
2830	6594	1099.0	229.65	38.3	The occurrence of sleep-disordered breathing among middle-aged adults.	T Young, M Palta, J Dempsey, J Skatrud, S Weber, S Badr	N Engl J Med	1993	8464434	Yes
2831	1099	1099.0	23.49	23.5	Basement membranes: structure, assembly and role in tumour angiogenesis.	Raghu Kalluri	Nat Rev Cancer	2003	12778132	No
2832	2197	1098.5	0.0	0.0	Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody.	A H Coons, M H Kaplan	J Exp Med	1950	15395569	Yes
2833	7689	1098.4	160.65	22.9	Exploration, normalization, and summaries of high density oligonucleotide array probe level data.	Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P Speed	Biostatistics	2003	12925520	Yes
2834	2196	1098.0	50.34	25.2	Adaptive protein evolution at the Adh locus in Drosophila.	J H McDonald, M Kreitman	Nature	1991	1904993	Yes
2835	1098	1098.0	44.45	44.5	Social phobia.	M R Liebowitz	Mod Probl Pharmacopsychiatry	1987	2885745	Yes
2836	1098	1098.0	0.0	0.0	The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion.	S Roseman	Chem Phys Lipids	1970	5476326	Yes
2837	1098	1098.0	23.08	23.1	Differentiation and proliferation of hematopoietic stem cells.	M Ogawa	Blood	1993	8499622	No
2838	1098	1098.0	29.17	29.2	Neural systems for recognizing emotion.	Ralph Adolphs	Curr Opin Neurobiol	2002	12015233	No
2839	1098	1098.0	0.0	0.0	Inherited Antithrombin Deficiency Causing Thrombophilia.	O Egeberg	Thromb Diath Haemorrh	1965	14347873	Yes
2840	2195	1097.5	0.0	0.0	Construction of phylogenetic trees.	W M Fitch, E Margoliash	Science	1967	5334057	No
2841	2195	1097.5	71.92	36.0	Excitatory amino acid transmitters.	J C Watkins, R H Evans	Annu Rev Pharmacol Toxicol	1981	6112965	No
2842	2195	1097.5	70.23	35.1	Natural products as sources of new drugs over the last 25 years.	David J Newman, Gordon M Cragg	J Nat Prod	2007	17309302	No
2843	1097	1097.0	104.22	104.2	The analysis of errors in orthodontic measurements.	W J Houston	Am J Orthod	1983	6573846	Yes
2844	2194	1097.0	53.22	26.6	Emerging roles of caspase-3 in apoptosis.	A G Porter, R U Jänicke	Cell Death Differ	1999	10200555	No
2845	1097	1097.0	30.89	30.9	Leishmaniasis.	B L Herwaldt	Lancet	1999	10513726	No
2846	1097	1097.0	0.0	0.0	A cytoarchitectonic atlas of the spinal cord in the cat.	B Rexed	J Comp Neurol	1954	13163236	Yes
2847	1097	1097.0	34.2	34.2	High prevalence of vitamin D inadequacy and implications for health.	Michael F Holick	Mayo Clin Proc	2006	16529140	No
2848	2194	1097.0	63.46	31.7	Meeting of minds: the medial frontal cortex and social cognition.	David M Amodio, Chris D Frith	Nat Rev Neurosci	2006	16552413	No
2849	1097	1097.0	0.0	0.0	Knee joint changes after meniscectomy.	T J Fairbank	J Bone Joint Surg Br	1948	18894618	Yes
2850	1096	1096.0	0.0	0.0	Sex-hormone-binding globulin.	D C Anderson	Clin Endocrinol (Oxf)	1974	4134992	No
2851	1096	1096.0	24.81	24.8	The molecular biology of leukocyte chemoattractant receptors.	P M Murphy	Annu Rev Immunol	1994	8011292	No
2852	2192	1096.0	45.6	22.8	An automated method for finding molecular complexes in large protein interaction networks.	Gary D Bader, Christopher W V Hogue	BMC Bioinformatics	2003	12525261	Yes
2853	1096	1096.0	36.56	36.6	Delirium in older persons.	Sharon K Inouye	N Engl J Med	2006	16540616	No
2854	4382	1095.5	121.09	30.3	Prevalence and trends in obesity among US adults, 1999-2000.	Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L Johnson	JAMA	2002	12365955	Yes
2855	1095	1095.0	22.32	22.3	Primary response genes induced by growth factors and tumor promoters.	H R Herschman	Annu Rev Biochem	1991	1883198	No
2856	1095	1095.0	30.97	31.0	Internal models for motor control and trajectory planning.	M Kawato	Curr Opin Neurobiol	1999	10607637	No
2857	2190	1095.0	61.44	30.7	Epidemiology and outcomes of osteoporotic fractures.	Steven R Cummings, L Joseph Melton	Lancet	2002	12049882	No
2858	2189	1094.5	96.28	48.1	Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity.	P R Hunter, M A Gaston	J Clin Microbiol	1988	3069867	Yes
2859	1093	1093.0	37.35	37.4	Selective attention and the organization of visual information.	J Duncan	J Exp Psychol Gen	1984	6240521	Yes
2860	1093	1093.0	0.0	0.0	Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins.	R D Owen	Science	1945	17755278	Yes
2861	1093	1093.0	28.85	28.9	Non-Smad pathways in TGF-beta signaling.	Ying E Zhang	Cell Res	2009	19114990	No
2862	1093	1093.0	38.81	38.8	Breakthrough of the year 2013. Cancer immunotherapy.	Jennifer Couzin-Frankel	Science	2013	24357284	No
2863	2186	1093.0	96.69	48.3	The future of immune checkpoint therapy.	Padmanee Sharma, James P Allison	Science	2015	25838373	No
2864	1092	1092.0	41.48	41.5	Omega-3 fatty acids in health and disease and in growth and development.	A P Simopoulos	Am J Clin Nutr	1991	1908631	No
2865	1092	1092.0	46.22	46.2	A cochlear frequency-position function for several species--29 years later.	D D Greenwood	J Acoust Soc Am	1990	2373794	Yes
2866	1092	1092.0	57.13	57.1	Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale.	Anna Maria Carlsson	Pain	1983	6602967	Yes
2867	2184	1092.0	44.29	22.1	Proliferation, cell cycle and apoptosis in cancer.	G I Evan, K H Vousden	Nature	2001	11357141	No
2868	1092	1092.0	30.53	30.5	Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS.	Paul Willner	Neuropsychobiology	2005	16037678	No
2869	1091	1091.0	39.42	39.4	Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases.	J N Wasserheit	Sex Transm Dis	1992	1595015	No
2870	1091	1091.0	41.99	42.0	The role of endothelium in the responses of vascular smooth muscle to drugs.	R F Furchgott	Annu Rev Pharmacol Toxicol	1984	6203480	No
2871	1091	1091.0	29.57	29.6	The neurobiology of stress: from serendipity to clinical relevance.	B S McEwen	Brain Res	2000	11119695	No
2872	1091	1091.0	0.0	0.0	Intra-sexual selection in Drosophila.	A J Bateman	Heredity (Edinb)	1948	18103134	Yes
2873	2182	1091.0	95.14	47.6	Neoantigens in cancer immunotherapy.	Ton N Schumacher, Robert D Schreiber	Science	2015	25838375	No
2874	1090	1090.0	21.33	21.3	Regulation of phosphoinositide-specific phospholipase C.	S G Rhee	Annu Rev Biochem	2001	11395409	No
2875	1090	1090.0	0.0	0.0	The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease.	J Vague	Am J Clin Nutr	1956	13282851	Yes
2876	1090	1090.0	0.0	0.0	Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow.	R M Berne	Am J Physiol	1963	13971060	Yes
2877	1090	1090.0	31.98	32.0	Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective.	Antoine Bechara	Nat Neurosci	2005	16251988	No
2878	2179	1089.5	97.34	48.7	The M1 and M2 paradigm of macrophage activation: time for reassessment.	Fernando O Martinez, Siamon Gordon	F1000Prime Rep	2014	24669294	No
2879	1089	1089.0	41.05	41.0	The P300 wave of the human event-related potential.	T W Picton	J Clin Neurophysiol	1992	1464675	No
2880	1089	1089.0	23.11	23.1	A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.	J Milbrandt	Science	1987	3672127	Yes
2881	1089	1089.0	45.31	45.3	Bone "mass" and the "mechanostat": a proposal.	H M Frost	Anat Rec	1987	3688455	Yes
2882	1089	1089.0	23.11	23.1	Apoptosis in neurodegenerative disorders.	M P Mattson	Nat Rev Mol Cell Biol	2000	11253364	No
2883	1089	1089.0	0.0	0.0	The purine and pyrimidine composition of deoxypentose nucleic acids.	G R Wyatt	Biochem J	1951	14838906	Yes
2884	2177	1088.5	62.83	31.4	Ageing and Parkinson's disease: substantia nigra regional selectivity.	J M Fearnley, A J Lees	Brain	1991	1933245	Yes
2885	1088	1088.0	22.99	23.0	T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex.	R H Schwartz	Annu Rev Immunol	1985	2415139	No
2886	5440	1088.0	189.92	38.0	Posttraumatic stress disorder in the National Comorbidity Survey.	R C Kessler, A Sonnega, E Bromet, M Hughes, C B Nelson	Arch Gen Psychiatry	1995	7492257	Yes
2887	1088	1088.0	30.83	30.8	Physiology and pathophysiology of purinergic neurotransmission.	Geoffrey Burnstock	Physiol Rev	2007	17429044	No
2888	4350	1087.5	157.11	39.3	Guidelines for the process of cross-cultural adaptation of self-report measures.	D E Beaton, C Bombardier, F Guillemin, M B Ferraz	Spine (Phila Pa 1976)	2000	11124735	No
2889	2174	1087.0	40.85	20.4	Hedgehog signaling in animal development: paradigms and principles.	P W Ingham, A P McMahon	Genes Dev	2001	11731473	No
2890	1087	1087.0	30.88	30.9	Mitochondrial fusion and fission in cell life and death.	Benedikt Westermann	Nat Rev Mol Cell Biol	2010	21102612	No
2891	2173	1086.5	76.94	38.5	The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis.	G P Chrousos, P W Gold	JAMA	1992	1538563	No
2892	2173	1086.5	47.55	23.8	The mammalian unfolded protein response.	Martin Schröder, Randal J Kaufman	Annu Rev Biochem	2005	15952902	No
2893	3259	1086.3	71.93	24.0	A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.	M Serrano, G J Hannon, D Beach	Nature	1993	8259215	Yes
2894	4345	1086.2	104.1	26.0	Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.	G L Wang, B H Jiang, E A Rue, G L Semenza	Proc Natl Acad Sci U S A	1995	7539918	Yes
2895	1086	1086.0	21.77	21.8	Cytokine receptor signalling.	J N Ihle	Nature	1995	7566171	No
2896	1086	1086.0	28.5	28.5	Overview of general physiologic features and functions of vitamin D.	Hector F DeLuca	Am J Clin Nutr	2004	15585789	No
2897	2172	1086.0	62.14	31.1	A neurotrophic model for stress-related mood disorders.	Ronald S Duman, Lisa M Monteggia	Biol Psychiatry	2006	16631126	No
2898	1086	1086.0	25.82	25.8	Human natural killer cells.	Michael A Caligiuri	Blood	2008	18650461	No
2899	2172	1086.0	73.95	37.0	Accessories to the crime: functions of cells recruited to the tumor microenvironment.	Douglas Hanahan, Lisa M Coussens	Cancer Cell	2012	22439926	No
2900	1086	1086.0	36.95	37.0	Mitochondria and cancer.	Douglas C Wallace	Nat Rev Cancer	2012	23001348	No
2901	1086	1086.0	66.22	66.2	The brain's default mode network.	Marcus E Raichle	Annu Rev Neurosci	2015	25938726	No
2902	1085	1085.0	0.0	0.0	Corticosteroids and lymphoid cells.	H N Claman	N Engl J Med	1972	5043524	Yes
2903	1085	1085.0	30.8	30.8	Pharmacology of cannabinoid CB1 and CB2 receptors.	R G Pertwee	Pharmacol Ther	1997	9336020	No
2904	1085	1085.0	27.7	27.7	Optical microcavities.	Kerry J Vahala	Nature	2003	12917698	Yes
2905	1085	1085.0	0.0	0.0	The relation of the trail making test to organic brain damage.	R M Reitan	J Consult Psychol	1955	13263471	Yes
2906	1085	1085.0	0.0	0.0	A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces.	M G Buonocore	J Dent Res	1955	13271655	Yes
2907	2170	1085.0	47.69	23.8	NF-kappaB: linking inflammation and immunity to cancer development and progression.	Michael Karin, Florian R Greten	Nat Rev Immunol	2005	16175180	No
2908	1084	1084.0	23.85	23.9	An overview of epithelio-mesenchymal transformation.	E D Hay	Acta Anat (Basel)	1995	8714286	No
2909	3250	1083.3	140.66	46.9	Multiple imputation using chained equations: Issues and guidance for practice.	Ian R White, Patrick Royston, Angela M Wood	Stat Med	2011	21225900	Yes
2910	1083	1083.0	0.0	0.0	Aniline hydrogen phthalate as a spraying reagent for chromatography of sugars.	S M Partridge	Nature	1949	18140444	Yes
2911	4330	1082.5	110.5	27.6	Autophagy fights disease through cellular self-digestion.	Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky	Nature	2008	18305538	No
2912	1082	1082.0	27.82	27.8	Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol.	M J Berridge	Biochem J	1983	6309155	Yes
2913	1082	1082.0	0.0	0.0	Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye.	P B Medawar	Br J Exp Pathol	1948	18865105	Yes
2914	1081	1081.0	0.0	0.0	A kinetic photometric method for serum gamma-glutamyl transpeptidase.	G Szasz	Clin Chem	1969	5773262	Yes
2915	1081	1081.0	32.27	32.3	Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing.	M J Gasson	J Bacteriol	1983	6403500	Yes
2916	1081	1081.0	31.73	31.7	The effects of stressful life events on depression.	R C Kessler	Annu Rev Psychol	1997	9046559	No
2917	1081	1081.0	30.39	30.4	Venous thrombosis: a multicausal disease.	F R Rosendaal	Lancet	1999	10209995	No
2918	2160	1080.0	81.99	41.0	Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal.	H Esterbauer, K H Cheeseman	Methods Enzymol	1990	2233308	Yes
2919	1080	1080.0	46.05	46.0	A spreading-activation theory of retrieval in sentence production.	G S Dell	Psychol Rev	1986	3749399	Yes
2920	1080	1080.0	0.0	0.0	The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs.	M Vogt	J Physiol	1954	13152692	Yes
2921	1080	1080.0	27.41	27.4	Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis.	R Balfour Sartor	Nat Clin Pract Gastroenterol Hepatol	2006	16819502	No
2922	2159	1079.5	43.7	21.9	RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression.	M B Shapiro, P Senapathy	Nucleic Acids Res	1987	3658675	Yes
2923	2159	1079.5	45.87	22.9	p53: puzzle and paradigm.	L J Ko, C Prives	Genes Dev	1996	8654922	No
2924	2159	1079.5	52.63	26.3	Cellular processing of platinum anticancer drugs.	Dong Wang, Stephen J Lippard	Nat Rev Drug Discov	2005	15789122	No
2925	1079	1079.0	32.13	32.1	The fetal and infant origins of adult disease.	D J Barker	BMJ	1990	2252919	No
2926	2158	1079.0	55.13	27.6	C-reactive protein: a critical update.	Mark B Pepys, Gideon M Hirschfield	J Clin Invest	2003	12813013	No
2927	1079	1079.0	33.42	33.4	Water as an active constituent in cell biology.	Philip Ball	Chem Rev	2008	18095715	No
2928	2157	1078.5	41.65	20.8	Dynamic instability of microtubule growth.	T Mitchison, M Kirschner	Nature	1984	6504138	Yes
2929	3235	1078.3	104.72	34.9	MR diffusion tensor spectroscopy and imaging.	P J Basser, J Mattiello, D LeBihan	Biophys J	1994	8130344	Yes
2930	1078	1078.0	0.0	0.0	Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method.	K Satoh	Clin Chim Acta	1978	719890	Yes
2931	1078	1078.0	22.07	22.1	A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development.	Xuemei Chen	Science	2004	12893888	Yes
2932	1078	1078.0	0.0	0.0	Cleavage of the haem-protein link by acid methylethylketone.	F W Teale	Biochim Biophys Acta	1959	13837237	Yes
2933	1078	1078.0	40.36	40.4	The amazing osteocyte.	Lynda F Bonewald	J Bone Miner Res	2011	21254230	No
2934	1077	1077.0	34.3	34.3	The oxidation hypothesis of atherosclerosis.	J L Witztum	Lancet	1994	7916078	No
2935	1077	1077.0	33.73	33.7	Context, time, and memory retrieval in the interference paradigms of Pavlovian learning.	M E Bouton	Psychol Bull	1993	8346330	No
2936	1076	1076.0	41.99	42.0	A new international staging system for lung cancer.	C F Mountain	Chest	1986	3514171	No
2937	1076	1076.0	0.0	0.0	A teacher rating scale for use in drug studies with children.	C K Conners	Am J Psychiatry	1969	4900822	Yes
2938	1076	1076.0	0.0	0.0	Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities.	F Fonnum	Biochem J	1969	4982085	Yes
2939	1076	1076.0	22.48	22.5	Inferences, questions and possibilities in Toll-like receptor signalling.	Bruce Beutler	Nature	2004	15241424	No
2940	3227	1075.7	107.71	35.9	Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS.	B K Matuszewski, M L Constanzer, C M Chavez-Eng	Anal Chem	2003	12964746	Yes
2941	2151	1075.5	0.0	0.0	Peroxidase-labeled antibody. A new method of conjugation.	P K Nakane, A Kawaoi	J Histochem Cytochem	1974	4443551	Yes
2942	2151	1075.5	68.76	34.4	Stochastic relaxation, gibbs distributions, and the bayesian restoration of images.	S Geman, D Geman	IEEE Trans Pattern Anal Mach Intell	1984	22499653	Yes
2943	1075	1075.0	25.92	25.9	Molecular drive: a cohesive mode of species evolution.	G Dover	Nature	1982	7110332	Yes
2944	1075	1075.0	34.08	34.1	Strategies of antioxidant defense.	H Sies	Eur J Biochem	1993	7688300	No
2945	2148	1074.0	0.0	0.0	Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme.	A Warshel, M Levitt	J Mol Biol	1976	985660	Yes
2946	1074	1074.0	30.81	30.8	Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens.	T Feizi	Nature	1985	2579340	Yes
2947	1074	1074.0	20.29	20.3	The development of neural stem cells.	S Temple	Nature	2001	11689956	No
2948	2147	1073.5	58.03	29.0	Oxidative stress, caloric restriction, and aging.	R S Sohal, R Weindruch	Science	1996	8658196	No
2949	1073	1073.0	37.72	37.7	Multiple organ failure. Pathophysiology and potential future therapy.	E A Deitch	Ann Surg	1992	1503516	No
2950	1073	1073.0	0.0	0.0	Asymptomatic infections of the urinary tract.	E H Kass	Trans Assoc Am Physicians	1956	13380946	Yes
2951	6436	1072.7	141.92	23.7	Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.	D A Melton, P A Krieg, M R Rebagliati, T Maniatis, K Zinn, M R Green	Nucleic Acids Res	1984	6091052	Yes
2952	2145	1072.5	66.35	33.2	2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity.	A Poland, J C Knutson	Annu Rev Pharmacol Toxicol	1982	6282188	No
2953	1072	1072.0	27.59	27.6	Selectins: interpreters of cell-specific carbohydrate information during inflammation.	L A Lasky	Science	1992	1439808	No
2954	1072	1072.0	32.66	32.7	A human model of gastric carcinogenesis.	P Correa	Cancer Res	1988	3288329	No
2955	1072	1072.0	32.35	32.4	Cholesterol and the cell membrane.	P L Yeagle	Biochim Biophys Acta	1985	3904832	No
2956	2144	1072.0	52.06	26.0	Quorum sensing in bacteria.	M B Miller, B L Bassler	Annu Rev Microbiol	2001	11544353	No
2957	1072	1072.0	59.54	59.5	Nonalcoholic fatty liver disease: a systematic review.	Mary E Rinella	JAMA	2015	26057287	No
2958	4287	1071.8	129.66	32.4	Toxic potential of materials at the nanolevel.	Andre Nel, Tian Xia, Lutz Mädler, Ning Li	Science	2006	16456071	No
2959	2142	1071.0	47.73	23.9	Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age.	T Hunter, J Pines	Cell	1994	7954824	No
2960	2142	1071.0	70.96	35.5	Modeling and comparison of dissolution profiles.	P Costa, J M Sousa Lobo	Eur J Pharm Sci	2001	11297896	No
2961	1071	1071.0	0.0	0.0	A New Serum Type System In Man--The Lp System.	K Berg	Acta Pathol Microbiol Scand	1963	14064818	Yes
2962	1070	1070.0	25.24	25.2	Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.	S H Kaufmann	Cancer Res	1989	2790800	Yes
2963	1070	1070.0	43.84	43.8	Freezing of living cells: mechanisms and implications.	P Mazur	Am J Physiol	1984	6383068	No
2964	1070	1070.0	25.25	25.2	Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial.	H J Dargie	Lancet	2001	11356434	Yes
2965	2140	1070.0	0.0	0.0	Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques.	P Gold, S O Freedman	J Exp Med	1965	14270243	Yes
2966	1070	1070.0	29.66	29.7	Functionalized acenes and heteroacenes for organic electronics.	John E Anthony	Chem Rev	2006	17165682	Yes
2967	1070	1070.0	61.36	61.4	Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial.	Kevin A Hallgren	Tutor Quant Methods Psychol	2012	22833776	Yes
2968	9626	1069.6	674.72	75.0	Cancer statistics in China, 2015.	Wanqing Chen, Rongshou Zheng, Peter D Baade, Siwei Zhang, Hongmei Zeng, Freddie Bray, Ahmedin Jemal, Xue Qin Yu, Jie He	CA Cancer J Clin	2016	26808342	Yes
2969	2139	1069.5	74.52	37.3	Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation.	A E Czeizel, I Dudás	N Engl J Med	1992	1307234	Yes
2970	1069	1069.0	32.85	32.9	What is synergy?	M C Berenbaum	Pharmacol Rev	1989	2692037	No
2971	1069	1069.0	27.05	27.1	The Trk family of neurotrophin receptors.	M Barbacid	J Neurobiol	1994	7852993	No
2972	1069	1069.0	37.23	37.2	beta-Lactamases in laboratory and clinical resistance.	D M Livermore	Clin Microbiol Rev	1995	8665470	No
2973	1069	1069.0	23.68	23.7	PHD: predicting one-dimensional protein structure by profile-based neural networks.	B Rost	Methods Enzymol	1996	8743704	Yes
2974	1069	1069.0	28.57	28.6	Disorders of iron metabolism.	N C Andrews	N Engl J Med	1999	10607817	No
2975	1069	1069.0	21.56	21.6	Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.	A S Baldwin	J Clin Invest	2001	11160144	No
2976	2138	1069.0	71.37	35.7	Chronic hepatitis B: update 2009.	Anna S F Lok, Brian J McMahon	Hepatology	2009	19714720	Yes
2977	2137	1068.5	48.39	24.2	Cell cycle control and cancer.	L H Hartwell, M B Kastan	Science	1994	7997877	No
2978	2136	1068.0	0.0	0.0	T antigen is bound to a host protein in SV40-transformed cells.	D P Lane, L V Crawford	Nature	1979	218111	Yes
2979	1068	1068.0	27.15	27.1	Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.	Hiroshi Takayanagi	Nat Rev Immunol	2007	17380158	No
2980	2135	1067.5	0.0	0.0	Binding of soluble form of fibroblast surface protein, fibronectin, to collagen.	E Engvall, E Ruoslahti	Int J Cancer	1977	903179	Yes
2981	2135	1067.5	64.03	32.0	Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report.	P Brugada, J Brugada	J Am Coll Cardiol	1992	1309182	Yes
2982	2135	1067.5	68.53	34.3	Glutamate and the pathophysiology of hypoxic--ischemic brain damage.	S M Rothman, J W Olney	Ann Neurol	1986	2421636	No
2983	1067	1067.0	31.2	31.2	A Wilcoxon-type test for trend.	J Cuzick	Stat Med	1985	3992076	Yes
2984	1067	1067.0	29.75	29.8	Aging, energy, and oxidative stress in neurodegenerative diseases.	M F Beal	Ann Neurol	1995	7668820	No
2985	1067	1067.0	25.26	25.3	Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach.	Michael J Sanderson	Mol Biol Evol	2002	11752195	Yes
2986	1067	1067.0	41.19	41.2	The role of autophagy in neurodegenerative disease.	Ralph A Nixon	Nat Med	2013	23921753	No
2987	1066	1066.0	0.0	0.0	A comparison of canal preparations in straight and curved root canals.	S W Schneider	Oral Surg Oral Med Oral Pathol	1971	5284110	Yes
2988	3197	1065.7	73.87	24.6	Adjusting batch effects in microarray expression data using empirical Bayes methods.	W Evan Johnson, Cheng Li, Ariel Rabinovic	Biostatistics	2007	16632515	Yes
2989	4262	1065.5	87.81	22.0	Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.	L Alexopoulou, A C Holt, R Medzhitov, R A Flavell	Nature	2001	11607032	Yes
2990	4262	1065.5	0.0	0.0	The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.	P J Randle, P B Garland, C N Hales, E A Newsholme	Lancet	1963	13990765	Yes
2991	4262	1065.5	125.06	31.3	Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond.	Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S Vasan	Stat Med	2008	17569110	Yes
2992	2131	1065.5	77.8	38.9	Modified RECIST (mRECIST) assessment for hepatocellular carcinoma.	Riccardo Lencioni, Josep M Llovet	Semin Liver Dis	2010	20175033	No
2993	1065	1065.0	0.0	0.0	Statistical quality control and routine data processing for radioimmunoassays and immunoradiometric assays.	D Rodbard	Clin Chem	1974	4370388	No
2994	1065	1065.0	25.51	25.5	Neurons with graded response have collective computational properties like those of two-state neurons.	J J Hopfield	Proc Natl Acad Sci U S A	1984	6587342	Yes
2995	1065	1065.0	26.59	26.6	The sphingomyelin cycle and the second messenger function of ceramide.	Y A Hannun	J Biol Chem	1994	8106344	No
2996	1065	1065.0	25.13	25.1	G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry.	Jeffery T Davis	Angew Chem Int Ed Engl	2004	14755695	No
2997	2129	1064.5	0.0	0.0	A microcolorimetric method for the determination of inorganic phosphorus.	H H Taussky, E Shorr	J Biol Chem	1953	13061491	Yes
2998	3192	1064.0	0.0	0.0	Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells.	M Jondal, G Holm, H Wigzell	J Exp Med	1972	4114496	Yes
2999	2128	1064.0	0.0	0.0	Calcium-dependent bacteriophage DNA infection.	M Mandel, A Higa	J Mol Biol	1970	4922220	Yes
3000	5320	1064.0	114.38	22.9	The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.	J W Harper, G R Adami, N Wei, K Keyomarsi, S J Elledge	Cell	1993	8242751	Yes
3001	1064	1064.0	51.25	51.2	Working memory: theories, models, and controversies.	Alan Baddeley	Annu Rev Psychol	2012	21961947	No
3002	2127	1063.5	48.02	24.0	Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy.	S W Hell, J Wichmann	Opt Lett	1994	19844443	Yes
3003	2127	1063.5	64.2	32.1	Integrins in cancer: biological implications and therapeutic opportunities.	Jay S Desgrosellier, David A Cheresh	Nat Rev Cancer	2010	20029421	No
3004	2127	1063.5	81.24	40.6	How good are my data and what is the resolution?	Philip R Evans, Garib N Murshudov	Acta Crystallogr D Biol Crystallogr	2013	23793146	Yes
3005	1063	1063.0	0.0	0.0	Association of the B-cell alloantigen DRw4 with rheumatoid arthritis.	P Stastny	N Engl J Med	1978	147420	Yes
3006	1063	1063.0	34.09	34.1	Relations between the statistics of natural images and the response properties of cortical cells.	D J Field	J Opt Soc Am A	1987	3430225	Yes
3007	1063	1063.0	0.0	0.0	Time-dependent processes in memory storage.	J L McGaugh	Science	1966	5917768	Yes
3008	4252	1063.0	142.14	35.5	The cholinergic hypothesis of geriatric memory dysfunction.	R T Bartus, R L Dean, B Beer, A S Lippa	Science	1982	7046051	No
3009	1063	1063.0	33.29	33.3	The somatic marker hypothesis and the possible functions of the prefrontal cortex.	A R Damasio	Philos Trans R Soc Lond B Biol Sci	1996	8941953	No
3010	1063	1063.0	19.29	19.3	Regulatory T cells in autoimmmunity*.	E M Shevach	Annu Rev Immunol	2000	10837065	No
3011	1063	1063.0	21.3	21.3	The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities.	Y Yarden	Eur J Cancer	2001	11597398	No
3012	1063	1063.0	21.35	21.4	The power and the promise of DNA methylation markers.	Peter W Laird	Nat Rev Cancer	2003	12671664	No
3013	3186	1062.0	86.58	28.9	Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.	R Schreck, P Rieber, P A Baeuerle	EMBO J	1991	2065663	Yes
3014	2124	1062.0	72.77	36.4	Physiological parameters in laboratory animals and humans.	B Davies, T Morris	Pharm Res	1993	8378254	No
3015	1062	1062.0	21.58	21.6	Coiled coils: new structures and new functions.	A Lupas	Trends Biochem Sci	1996	8918191	No
3016	1062	1062.0	24.22	24.2	The enzymes, regulation, and genetics of bile acid synthesis.	David W Russell	Annu Rev Biochem	2003	12543708	No
3017	1062	1062.0	26.01	26.0	Evaluating medication effects outside of clinical trials: new-user designs.	Wayne A Ray	Am J Epidemiol	2003	14585769	Yes
3018	2124	1062.0	73.7	36.9	Plasmonics for improved photovoltaic devices.	Harry A Atwater, Albert Polman	Nat Mater	2010	20168344	Yes
3019	2123	1061.5	0.0	0.0	The growth of mouse bone marrow cells in vitro.	T R Bradley, D Metcalf	Aust J Exp Biol Med Sci	1966	4164182	Yes
3020	2123	1061.5	75.19	37.6	Pharmaceuticals and personal care products in the environment: agents of subtle change?	C G Daughton, T A Ternes	Environ Health Perspect	1999	10592150	No
3021	2123	1061.5	49.41	24.7	Defining the role of mTOR in cancer.	David A Guertin, David M Sabatini	Cancer Cell	2007	17613433	No
3022	3184	1061.3	89.01	29.7	Bacterial biofilms: from the natural environment to infectious diseases.	Luanne Hall-Stoodley, J William Costerton, Paul Stoodley	Nat Rev Microbiol	2004	15040259	No
3023	1061	1061.0	0.0	0.0	Functional connections between cells as revealed by dye-coupling with a highly fluorescent naphthalimide tracer.	W W Stewart	Cell	1978	688392	Yes
3024	2122	1061.0	55.08	27.5	Statistical tests of neutrality of mutations.	Y X Fu, W H Li	Genetics	1993	8454210	Yes
3025	1060	1060.0	36.05	36.0	High density lipoprotein metabolism.	S Eisenberg	J Lipid Res	1984	6392459	No
3026	1060	1060.0	18.89	18.9	Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism.	M S Wold	Annu Rev Biochem	1997	9242902	No
3027	2120	1060.0	51.27	25.6	Hepatitis C virus infection.	G M Lauer, B D Walker	N Engl J Med	2001	11439948	No
3028	1060	1060.0	23.79	23.8	Assortative mixing in networks.	M E J Newman	Phys Rev Lett	2002	12443515	Yes
3029	1060	1060.0	36.55	36.5	Socioeconomic status and obesity.	Lindsay McLaren	Epidemiol Rev	2007	17478442	No
3030	2120	1060.0	51.88	25.9	Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis.	Jing Yang, Robert A Weinberg	Dev Cell	2008	18539112	No
3031	6359	1059.8	164.02	27.3	Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients.	S Yusuf, P Sleight, J Pogue, J Bosch, R Davies, G Dagenais	N Engl J Med	2000	10639539	Yes
3032	2119	1059.5	44.81	22.4	Sequence logos: a new way to display consensus sequences.	T D Schneider, R M Stephens	Nucleic Acids Res	1990	2172928	Yes
3033	2119	1059.5	42.75	21.4	Rho GTPases: biochemistry and biology.	Aron B Jaffe, Alan Hall	Annu Rev Cell Dev Biol	2005	16212495	No
3034	2118	1059.0	62.06	31.0	The acute phase response.	H Baumann, J Gauldie	Immunol Today	1994	7512342	No
3035	1059	1059.0	25.32	25.3	Selectins and their ligands: current concepts and controversies.	G S Kansas	Blood	1996	8896391	No
3036	1059	1059.0	23.4	23.4	Fluorescence spectroscopy of single biomolecules.	S Weiss	Science	1999	10073925	No
3037	2118	1059.0	0.0	0.0	Histochemistry of hepatic phosphatases of a physiologic pH; with special reference to the demonstration of bile canaliculi.	M Wachstein, E Meisel	Am J Clin Pathol	1957	13410831	Yes
3038	2118	1059.0	49.87	24.9	The canonical Notch signaling pathway: unfolding the activation mechanism.	Raphael Kopan, Maria Xenia G Ilagan	Cell	2009	19379690	No
3039	2118	1059.0	89.65	44.8	PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data.	Daniel R Roe, Thomas E Cheatham	J Chem Theory Comput	2013	26583988	Yes
3040	3176	1058.7	81.81	27.3	Evolution and functions of long noncoding RNAs.	Chris P Ponting, Peter L Oliver, Wolf Reik	Cell	2009	19239885	No
3041	2117	1058.5	0.0	0.0	The pathogenesis of atherosclerosis (first of two parts).	R Ross, J A Glomset	N Engl J Med	1976	819830	No
3042	1058	1058.0	30.17	30.2	Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine.	E M Tan	Adv Immunol	1982	6182766	No
3043	2116	1058.0	52.84	26.4	Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival.	Josep M Llovet, Jordi Bruix	Hepatology	2003	12540794	No
3044	2115	1057.5	0.0	0.0	Use of glucose oxidase, peroxidase, and O-dianisidine in determination of blood and urinary glucose.	A S Huggett, D A Nixon	Lancet	1957	13464070	Yes
3045	5286	1057.2	266.41	53.3	Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee.	N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W Stitt	J Rheumatol	1988	3068365	Yes
3046	6343	1057.2	213.06	35.5	A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.	Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier	Science	2012	22745249	Yes
3047	1057	1057.0	26.25	26.2	Plant salt tolerance.	J K Zhu	Trends Plant Sci	2001	11173290	Yes
3048	2114	1057.0	67.62	33.8	Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC).	Kathryn M Connor, Jonathan R T Davidson	Depress Anxiety	2003	12964174	Yes
3049	1057	1057.0	40.25	40.2	Synopsis of some recent tactical application of bioisosteres in drug design.	Nicholas A Meanwell	J Med Chem	2011	21413808	Yes
3050	2113	1056.5	50.7	25.4	Shape-controlled synthesis of gold and silver nanoparticles.	Yugang Sun, Younan Xia	Science	2002	12481134	Yes
3051	1056	1056.0	32.05	32.0	Analyzing the mosaic structure of genes.	J M Smith	J Mol Evol	1992	1556748	No
3052	2112	1056.0	66.29	33.1	A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data.	A Ennaceur, J Delacour	Behav Brain Res	1988	3228475	Yes
3053	1056	1056.0	0.0	0.0	Cell lines derived from late embryonic stages of Drosophila melanogaster.	I Schneider	J Embryol Exp Morphol	1972	4625067	Yes
3054	3168	1056.0	82.08	27.4	Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm.	Y Zhang, M Brady, S Smith	IEEE Trans Med Imaging	2001	11293691	Yes
3055	2112	1056.0	0.0	0.0	Chronic catheterization of the spinal subarachnoid space.	T L Yaksh, T A Rudy	Physiol Behav	1976	14677603	Yes
3056	2111	1055.5	45.35	22.7	Mitogen-activated protein kinase pathways.	M J Robinson, M H Cobb	Curr Opin Cell Biol	1997	9069255	No
3057	2111	1055.5	55.96	28.0	Protein oxidation in aging, disease, and oxidative stress.	B S Berlett, E R Stadtman	J Biol Chem	1997	9252331	No
3058	4222	1055.5	106.66	26.7	C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women.	P M Ridker, C H Hennekens, J E Buring, N Rifai	N Engl J Med	2000	10733371	Yes
3059	2111	1055.5	65.67	32.8	Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications.	Xiaobo Chen, Samuel S Mao	Chem Rev	2007	17590053	Yes
3060	1055	1055.0	24.8	24.8	Current concepts of the pathogenesis of the acute coronary syndromes.	P Libby	Circulation	2001	11457759	No
3061	1055	1055.0	21.79	21.8	VEGF and the quest for tumour angiogenesis factors.	Napoleone Ferrara	Nat Rev Cancer	2002	12360282	No
3062	1055	1055.0	46.75	46.8	Cytokines in inflammatory bowel disease.	Markus F Neurath	Nat Rev Immunol	2014	24751956	No
3063	6329	1054.8	199.49	33.2	Free radicals and antioxidants in normal physiological functions and human disease.	Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua Telser	Int J Biochem Cell Biol	2007	16978905	No
3064	4217	1054.2	161.4	40.4	Prevalence and trends in obesity among US adults, 1999-2008.	Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R Curtin	JAMA	2010	20071471	Yes
3065	1054	1054.0	24.06	24.1	The inducible transcription activator NF-kappa B: regulation by distinct protein subunits.	P A Baeuerle	Biochim Biophys Acta	1991	2018779	No
3066	1054	1054.0	25.7	25.7	Aptamers: an emerging class of molecules that rival antibodies in diagnostics.	S D Jayasena	Clin Chem	1999	10471678	No
3067	1054	1054.0	26.16	26.2	The impact of next-generation sequencing technology on genetics.	Elaine R Mardis	Trends Genet	2008	18262675	No
3068	1054	1054.0	25.71	25.7	Next-generation DNA sequencing methods.	Elaine R Mardis	Annu Rev Genomics Hum Genet	2008	18576944	No
3069	6323	1053.8	217.98	36.3	Antioxidant activity applying an improved ABTS radical cation decolorization assay.	R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-Evans	Free Radic Biol Med	1999	10381194	Yes
3070	2107	1053.5	57.86	28.9	Hydrogels for tissue engineering: scaffold design variables and applications.	Jeanie L Drury, David J Mooney	Biomaterials	2003	12922147	No
3071	4213	1053.2	0.0	0.0	Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm.	L A Papile, J Burstein, R Burstein, H Koffler	J Pediatr	1978	305471	Yes
3072	1053	1053.0	25.77	25.8	The granulocyte-macrophage colony-stimulating factors.	D Metcalf	Science	1985	2990035	No
3073	1053	1053.0	0.0	0.0	A colorimetric method for estimating serum triglycerides.	M J Fletcher	Clin Chim Acta	1968	5696963	Yes
3074	1053	1053.0	41.74	41.7	Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error.	J T Daugirdas	J Am Soc Nephrol	1993	8305648	Yes
3075	2106	1053.0	44.3	22.1	A survey of telomerase activity in human cancer.	J W Shay, S Bacchetti	Eur J Cancer	1997	9282118	No
3076	2105	1052.5	76.64	38.3	Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry.	A I Basbaum, H L Fields	Annu Rev Neurosci	1984	6143527	No
3077	1052	1052.0	29.09	29.1	T-cell growth factor.	K A Smith	Immunol Rev	1980	7000676	No
3078	1052	1052.0	25.39	25.4	Cells in stress: transcriptional activation of heat shock genes.	R I Morimoto	Science	1993	8451637	No
3079	1052	1052.0	31.58	31.6	Infection in solid-organ transplant recipients.	Jay A Fishman	N Engl J Med	2007	18094380	No
3080	4206	1051.5	0.0	0.0	T cell growth factor: parameters of production and a quantitative microassay for activity.	S Gillis, M M Ferm, W Ou, K A Smith	J Immunol	1978	307029	Yes
3081	1051	1051.0	21.85	21.9	The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells.	D Metcalf	Nature	1989	2469962	No
3082	1051	1051.0	0.0	0.0	The ultrastructural basis of capillary permeability studied with peroxidase as a tracer.	M J Karnovsky	J Cell Biol	1967	6061717	Yes
3083	2102	1051.0	52.65	26.3	Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology.	M E Feder, G E Hofmann	Annu Rev Physiol	1999	10099689	No
3084	1051	1051.0	24.27	24.3	The myofibroblast in wound healing and fibrocontractive diseases.	G Gabbiani	J Pathol	2003	12845617	No
3085	1051	1051.0	0.0	0.0	Fertilizing capacity of spermatozoa deposited into the fallopian tubes.	M C Chang	Nature	1951	14882325	Yes
3086	1051	1051.0	24.08	24.1	Version 1.2 of the Crystallography and NMR system.	Axel T Brunger	Nat Protoc	2007	18007608	Yes
3087	2101	1050.5	45.66	22.8	The Hsp70 and Hsp60 chaperone machines.	B Bukau, A L Horwich	Cell	1998	9476895	No
3088	2101	1050.5	45.17	22.6	Plant pathogens and integrated defence responses to infection.	J L Dangl, J D Jones	Nature	2001	11459065	No
3089	2100	1050.0	63.58	31.8	The biochemistry of P-glycoprotein-mediated multidrug resistance.	J A Endicott, V Ling	Annu Rev Biochem	1989	2570548	No
3090	1050	1050.0	39.29	39.3	Coronary physiology.	E O Feigl	Physiol Rev	1983	6296890	No
3091	1050	1050.0	29.65	29.6	Determination of total protein.	G L Peterson	Methods Enzymol	1983	6855607	Yes
3092	1050	1050.0	23.6	23.6	ECM and cell surface proteolysis: regulating cellular ecology.	Z Werb	Cell	1997	9390552	No
3093	2100	1050.0	53.99	27.0	The protective effects of estrogen on the cardiovascular system.	M E Mendelsohn, R H Karas	N Engl J Med	1999	10362825	No
3094	2099	1049.5	49.4	24.7	Esophageal cancer.	Peter C Enzinger, Robert J Mayer	N Engl J Med	2003	14657432	No
3095	1049	1049.0	26.99	27.0	Axonal growth-associated proteins.	J H Skene	Annu Rev Neurosci	1989	2648946	No
3096	1049	1049.0	20.33	20.3	At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells.	M Kozak	J Mol Biol	1987	3681984	Yes
3097	1049	1049.0	0.0	0.0	Lipid peroxidation damage to cell components.	A L Tappel	Fed Proc	1973	4352451	Yes
3098	2098	1049.0	60.04	30.0	Biology of incretins: GLP-1 and GIP.	Laurie L Baggio, Daniel J Drucker	Gastroenterology	2007	17498508	No
3099	4194	1048.5	217.84	54.5	National Institute of Mental Health Diagnostic Interview Schedule. Its history, characteristics, and validity.	L N Robins, J E Helzer, J Croughan, K S Ratcliff	Arch Gen Psychiatry	1981	6260053	Yes
3100	2096	1048.0	41.14	20.6	Improved retroviral vectors for gene transfer and expression.	A D Miller, G J Rosman	Biotechniques	1989	2631796	Yes
3101	1048	1048.0	19.99	20.0	Chronic myeloid leukemia.	C L Sawyers	N Engl J Med	1999	10219069	No
3102	1048	1048.0	24.04	24.0	Pedigree disequilibrium tests for multilocus haplotypes.	Frank Dudbridge	Genet Epidemiol	2003	12916020	Yes
3103	1048	1048.0	36.25	36.2	phangorn: phylogenetic analysis in R.	Klaus Peter Schliep	Bioinformatics	2011	21169378	Yes
3104	2096	1048.0	138.38	69.2	The amyloid hypothesis of Alzheimer's disease at 25 years.	Dennis J Selkoe, John Hardy	EMBO Mol Med	2016	27025652	No
3105	2095	1047.5	68.82	34.4	Wine, alcohol, platelets, and the French paradox for coronary heart disease.	S Renaud, M de Lorgeril	Lancet	1992	1351198	Yes
3106	2095	1047.5	0.0	0.0	Cortisone in ulcerative colitis; final report on a therapeutic trial.	S C Truelove, L J Witts	Br Med J	1955	13260656	Yes
3107	1047	1047.0	29.82	29.8	Mitochondrial genetics: a paradigm for aging and degenerative diseases?	D C Wallace	Science	1992	1533953	Yes
3108	1047	1047.0	40.58	40.6	Infection by verocytotoxin-producing Escherichia coli.	M A Karmali	Clin Microbiol Rev	1989	2644022	No
3109	1047	1047.0	0.0	0.0	Epidemiology of cancer of the colon and rectum.	D P Burkitt	Cancer	1971	5165022	Yes
3110	1047	1047.0	34.11	34.1	Platelet-rich plasma: evidence to support its use.	Robert E Marx	J Oral Maxillofac Surg	2004	15085519	No
3111	1047	1047.0	22.4	22.4	Liver regeneration: from myth to mechanism.	Rebecca Taub	Nat Rev Mol Cell Biol	2004	15459664	No
3112	1047	1047.0	35.66	35.7	Persister cells.	Kim Lewis	Annu Rev Microbiol	2010	20528688	No
3113	1046	1046.0	22.09	22.1	mRNA stability in mammalian cells.	J Ross	Microbiol Rev	1995	7565413	No
3114	1046	1046.0	28.3	28.3	The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices.	R A Jain	Biomaterials	2000	11055295	No
3115	1046	1046.0	0.0	0.0	The Permeability Of Capillaries In Various Organs As Determined By Use Of The 'Indicator Diffusion' Method.	C Crone	Acta Physiol Scand	1963	14078649	Yes
3116	1045	1045.0	0.0	0.0	Microtubule formation in vitro in solutions containing low calcium concentrations.	R C Weisenberg	Science	1972	4626639	Yes
3117	1045	1045.0	25.76	25.8	A tension-based theory of morphogenesis and compact wiring in the central nervous system.	D C Van Essen	Nature	1997	9002514	Yes
3118	1045	1045.0	36.11	36.1	Checklists for improving rigour in qualitative research: a case of the tail wagging the dog?	R S Barbour	BMJ	2001	11337448	No
3119	1044	1044.0	0.0	0.0	Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice.	D L Coleman	Diabetologia	1978	350680	No
3120	2088	1044.0	102.77	51.4	Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique.	S F Dworkin, L LeResche	J Craniomandib Disord	1992	1298767	No
3121	1044	1044.0	18.23	18.2	Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast.	R Rothstein	Methods Enzymol	1991	2005793	Yes
3122	1044	1044.0	30.17	30.2	Junctional intercellular communication: the cell-to-cell membrane channel.	W R Loewenstein	Physiol Rev	1981	6270711	No
3123	2088	1044.0	0.0	0.0	A modified ninhydrin reagent for the photometric determination of amino acids and related compounds.	S Moore, W H Stein	J Biol Chem	1954	13221596	Yes
3124	1044	1044.0	0.0	0.0	Fluorescent antibody methods.	A H Coons	Gen Cytochem Methods	1958	13574437	Yes
3125	1044	1044.0	21.37	21.4	Regulation of cadherin-mediated adhesion in morphogenesis.	Barry M Gumbiner	Nat Rev Mol Cell Biol	2005	16025097	No
3126	6264	1044.0	185.72	31.0	Cancer statistics, 2007.	Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Taylor Murray, Jiaquan Xu, Michael J Thun	CA Cancer J Clin	2007	17237035	Yes
3127	1044	1044.0	37.8	37.8	The epidemiology of adult obstructive sleep apnea.	Naresh M Punjabi	Proc Am Thorac Soc	2008	18250205	No
3128	2087	1043.5	0.0	0.0	A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250.	J J Sedmak, S E Grossberg	Anal Biochem	1977	68686	Yes
3129	1043	1043.0	37.74	37.7	Density matrix formulation for quantum renormalization groups.	White	Phys Rev Lett	1992	10046608	Yes
3130	2084	1042.0	77.66	38.8	Fingerprinting genomes using PCR with arbitrary primers.	J Welsh, M McClelland	Nucleic Acids Res	1990	2259619	Yes
3131	1042	1042.0	0.0	0.0	The epidemiologic transition. A theory of the epidemiology of population change.	A R Omran	Milbank Mem Fund Q	1971	5155251	Yes
3132	1042	1042.0	31.8	31.8	Modeling tracer kinetics in dynamic Gd-DTPA MR imaging.	P S Tofts	J Magn Reson Imaging	1997	9039598	No
3133	1042	1042.0	39.78	39.8	AmpC beta-lactamases.	George A Jacoby	Clin Microbiol Rev	2009	19136439	No
3134	1041	1041.0	0.0	0.0	Carcinoid tumors. An analysis of 2,837 cases.	J D Godwin	Cancer	1975	1157019	Yes
3135	2082	1041.0	48.23	24.1	Synaptic activity and the construction of cortical circuits.	L C Katz, C J Shatz	Science	1996	8895456	No
3136	1041	1041.0	35.96	36.0	Socioeconomic disadvantage and child development.	V C McLoyd	Am Psychol	1998	9491747	No
3137	1041	1041.0	19.89	19.9	The ubiquitin-proteasome pathway: on protein death and cell life.	A Ciechanover	EMBO J	1998	9857172	No
3138	1041	1041.0	20.71	20.7	Focal adhesion kinase: the first ten years.	J Thomas Parsons	J Cell Sci	2003	12640026	No
3139	1041	1041.0	0.0	0.0	Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig.	G D Winter	Nature	1962	14007593	Yes
3140	2080	1040.0	51.17	25.6	Efficient isolation of genes by using antibody probes.	R A Young, R W Davis	Proc Natl Acad Sci U S A	1983	6219389	Yes
3141	3120	1040.0	74.26	24.8	Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo.	Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen	Science	2005	15831717	Yes
3142	1039	1039.0	41.76	41.8	Geriatric Depression Scale.	J A Yesavage	Psychopharmacol Bull	1988	3249773	Yes
3143	1039	1039.0	27.67	27.7	Neuropathology of Parkinson's disease.	L S Forno	J Neuropathol Exp Neurol	1996	8786384	No
3144	1038	1038.0	26.97	27.0	Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system.	J P Tam	Proc Natl Acad Sci U S A	1988	3399498	Yes
3145	2076	1038.0	53.87	26.9	Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis.	M S Brown, J L Goldstein	Annu Rev Biochem	1983	6311077	No
3146	1038	1038.0	41.32	41.3	Amyloid deposits and amyloidosis: the beta-fibrilloses (second of two parts).	G G Glenner	N Engl J Med	1980	6990257	No
3147	1038	1038.0	19.47	19.5	The Pezcoller lecture: cancer cell cycles revisited.	C J Sherr	Cancer Res	2000	10919634	No
3148	1038	1038.0	27.89	27.9	Electrochemiluminescence (ECL).	Mark M Richter	Chem Rev	2004	15186186	No
3149	2076	1038.0	59.04	29.5	EasySpin, a comprehensive software package for spectral simulation and analysis in EPR.	Stefan Stoll, Arthur Schweiger	J Magn Reson	2006	16188474	Yes
3150	1038	1038.0	22.4	22.4	Protein tyrosine phosphatases: from genes, to function, to disease.	Nicholas K Tonks	Nat Rev Mol Cell Biol	2006	17057753	No
3151	2076	1038.0	100.47	50.2	Alginate: properties and biomedical applications.	Kuen Yong Lee, David J Mooney	Prog Polym Sci	2012	22125349	Yes
3152	2075	1037.5	0.0	0.0	A simple method for the preparation of 32-P-labelled adenosine triphosphate of high specific activity.	I M Glynn, J B Chappell	Biochem J	1964	5832284	Yes
3153	2075	1037.5	50.65	25.3	A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure.	J N Cohn, G Tognoni	N Engl J Med	2001	11759645	Yes
3154	1037	1037.0	0.0	0.0	Cell communication, calcium ion, and cyclic adenosine monophosphate.	H Rasmussen	Science	1970	4318972	Yes
3155	1037	1037.0	30.49	30.5	Nitric oxide synthase structure and mechanism.	M A Marletta	J Biol Chem	1993	7685338	No
3156	1037	1037.0	30.38	30.4	Pathogenetic mechanisms of septic shock.	J E Parrillo	N Engl J Med	1993	8479467	No
3157	1037	1037.0	29.77	29.8	Thermo- and pH-responsive polymers in drug delivery.	Dirk Schmaljohann	Adv Drug Deliv Rev	2006	17125884	No
3158	1037	1037.0	0.0	0.0	A Serological Differentiation Of Human And Other Groups Of Hemolytic Streptococci.	R C Lancefield	J Exp Med	1933	19870148	Yes
3159	2073	1036.5	63.3	31.6	Physiological time-series analysis using approximate entropy and sample entropy.	J S Richman, J R Moorman	Am J Physiol Heart Circ Physiol	2000	10843903	Yes
3160	5181	1036.2	101.86	20.4	The protein kinase complement of the human genome.	G Manning, D B Whyte, R Martinez, T Hunter, S Sudarsanam	Science	2002	12471243	No
3161	1036	1036.0	0.0	0.0	Transformation of yeast by a replicating hybrid plasmid.	J D Beggs	Nature	1978	357984	Yes
3162	8288	1036.0	260.65	32.6	The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment.	Ziad S Nasreddine, Natalie A Phillips, Valérie Bédirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard Chertkow	J Am Geriatr Soc	2005	15817019	Yes
3163	1036	1036.0	30.02	30.0	Persister cells, dormancy and infectious disease.	Kim Lewis	Nat Rev Microbiol	2007	17143318	No
3164	2071	1035.5	53.67	26.8	Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis.	D C Schwartz, C R Cantor	Cell	1984	6373014	Yes
3165	2071	1035.5	47.4	23.7	Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set.	N Sreerama, R W Woody	Anal Biochem	2000	11112271	Yes
3166	3105	1035.0	112.3	37.4	Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material.	P S Walsh, D A Metzger, R Higuchi	Biotechniques	1991	1867860	Yes
3167	1035	1035.0	0.0	0.0	Retention of differentiation potentialities during prolonged cultivation of myogenic cells.	D Yaffe	Proc Natl Acad Sci U S A	1968	5245982	Yes
3168	1035	1035.0	0.0	0.0	Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse.	S Irwin	Psychopharmacologia	1968	5679627	Yes
3169	1035	1035.0	30.41	30.4	Muscarinic receptors--characterization, coupling and function.	M P Caulfield	Pharmacol Ther	1993	7504306	No
3170	1035	1035.0	29.73	29.7	Disseminating innovations in health care.	Donald M Berwick	JAMA	2003	12697800	Yes
3171	1035	1035.0	36.25	36.2	How stigma interferes with mental health care.	Patrick Corrigan	Am Psychol	2004	15491256	Yes
3172	1035	1035.0	30.64	30.6	A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors.	Ron Hardman	Environ Health Perspect	2006	16451849	No
3173	1035	1035.0	0.0	0.0	A Protection Motivation Theory of Fear Appeals and Attitude Change1.	Ronald W Rogers	J Psychol	1975	28136248	Yes
3174	2069	1034.5	52.36	26.2	Cell cycle, CDKs and cancer: a changing paradigm.	Marcos Malumbres, Mariano Barbacid	Nat Rev Cancer	2009	19238148	No
3175	1034	1034.0	27.84	27.8	Human TH1 and TH2 subsets: doubt no more.	S Romagnani	Immunol Today	1991	1680337	Yes
3176	1034	1034.0	34.91	34.9	Fever: role of pyrogens and cryogens.	M J Kluger	Physiol Rev	1991	1986393	No
3177	2068	1034.0	44.44	22.2	The immunoglobulin superfamily--domains for cell surface recognition.	A F Williams, A N Barclay	Annu Rev Immunol	1988	3289571	No
3178	1034	1034.0	23.31	23.3	Complement. Second of two parts.	M J Walport	N Engl J Med	2001	11297706	No
3179	1034	1034.0	24.13	24.1	Toward self-organization and complex matter.	Jean-Marie Lehn	Science	2002	11923524	Yes
3180	1034	1034.0	20.14	20.1	Biological robustness.	Hiroaki Kitano	Nat Rev Genet	2004	15520792	No
3181	1034	1034.0	0.0	0.0	Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent.	D L Morris	Science	1948	17814729	Yes
3182	1033	1033.0	0.0	0.0	Mechanisms of lipid peroxide formation in animal tissues.	E D Wills	Biochem J	1966	5964963	Yes
3183	1032	1032.0	0.0	0.0	The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture.	J Cassel	Am J Epidemiol	1976	782233	No
3184	1032	1032.0	23.37	23.4	Molecular imaging of cancer with positron emission tomography.	Sanjiv Sam Gambhir	Nat Rev Cancer	2002	12209157	No
3185	1032	1032.0	0.0	0.0	The effect of emotion on cue utilization and the organization of behavior.	J A Easterbrook	Psychol Rev	1959	13658305	Yes
3186	2064	1032.0	57.44	28.7	Morris water maze: procedures for assessing spatial and related forms of learning and memory.	Charles V Vorhees, Michael T Williams	Nat Protoc	2006	17406317	Yes
3187	1032	1032.0	46.08	46.1	The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults.	L S Radloff	J Youth Adolesc	1991	24265004	Yes
3188	4126	1031.5	108.91	27.2	Real time quantitative PCR.	C A Heid, J Stevens, K J Livak, P M Williams	Genome Res	1996	8908518	Yes
3189	5157	1031.4	209.37	41.9	The hallmarks of aging.	Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer	Cell	2013	23746838	No
3190	3094	1031.3	102.69	34.2	Qualitative research in health care. Analysing qualitative data.	C Pope, S Ziebland, N Mays	BMJ	2000	10625273	No
3191	4125	1031.2	84.72	21.2	Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells.	E Schreiber, P Matthias, M M Müller, W Schaffner	Nucleic Acids Res	1989	2771659	Yes
3192	1031	1031.0	29.7	29.7	Transport of molecules in the tumor interstitium: a review.	R K Jain	Cancer Res	1987	3555767	No
3193	1031	1031.0	0.0	0.0	The role of calcium in the release of neurotransmitter substances and hormones.	R P Rubin	Pharmacol Rev	1970	4322219	No
3194	1031	1031.0	32.27	32.3	Inferring microstructural features and the physiological state of tissues from diffusion-weighted images.	P J Basser	NMR Biomed	1995	8739270	No
3195	1031	1031.0	30.78	30.8	The pollution of the marine environment by plastic debris: a review.	José G B Derraik	Mar Pollut Bull	2002	12405208	No
3196	1031	1031.0	0.0	0.0	A production of amino acids under possible primitive earth conditions.	S L Miller	Science	1953	13056598	Yes
3197	1031	1031.0	39.56	39.6	Volumetric modulated arc therapy: IMRT in a single gantry arc.	Karl Otto	Med Phys	2008	18293586	Yes
3198	3093	1031.0	122.95	41.0	Hepatocellular carcinoma.	Alejandro Forner, Josep M Llovet, Jordi Bruix	Lancet	2012	22353262	No
3199	2061	1030.5	46.23	23.1	Protein-tyrosine kinases.	T Hunter, J A Cooper	Annu Rev Biochem	1985	2992362	No
3200	2061	1030.5	64.64	32.3	Tumor metastasis: molecular insights and evolving paradigms.	Scott Valastyan, Robert A Weinberg	Cell	2011	22000009	No
3201	3091	1030.3	0.0	0.0	Therapeutic criteria in rheumatoid arthritis.	O Steinbrocker, C H Traeger, R C Batterman	J Am Med Assoc	1949	18150288	Yes
3202	1030	1030.0	0.0	0.0	Surface modulation in cell recognition and cell growth.	G M Edelman	Science	1976	769162	No
3203	2060	1030.0	41.27	20.6	A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli.	C S Hoffman, F Winston	Gene	1987	3319781	Yes
3204	1030	1030.0	36.45	36.5	A review of psychological risk factors in back and neck pain.	S J Linton	Spine (Phila Pa 1976)	2000	10788861	No
3205	1030	1030.0	31.86	31.9	The Hospital Anxiety And Depression Scale.	R Philip Snaith	Health Qual Life Outcomes	2003	12914662	Yes
3206	2060	1030.0	64.81	32.4	Toll-like receptors and their crosstalk with other innate receptors in infection and immunity.	Taro Kawai, Shizuo Akira	Immunity	2011	21616434	No
3207	1030	1030.0	48.5	48.5	α-band oscillations, attention, and controlled access to stored information.	Wolfgang Klimesch	Trends Cogn Sci	2012	23141428	No
3208	5149	1029.8	162.27	32.5	Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure.	Salim Yusuf, Bertram Pitt, Clarence E Davis, William B Hood, Jay N Cohn	N Engl J Med	1991	2057034	Yes
3209	2059	1029.5	79.34	39.7	A psychomotor stimulant theory of addiction.	R A Wise, M A Bozarth	Psychol Rev	1987	3317472	No
3210	2059	1029.5	54.04	27.0	Hydrogels for tissue engineering.	K Y Lee, D J Mooney	Chem Rev	2001	11710233	No
3211	2059	1029.5	0.0	0.0	Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran.	R R Guillard, J H Ryther	Can J Microbiol	1962	13902807	Yes
3212	1029	1029.0	26.87	26.9	Two-stage model of memory trace formation: a role for "noisy" brain states.	G Buzsáki	Neuroscience	1989	2687720	No
3213	2058	1029.0	61.5	30.8	Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation.	J M Reul, E R de Kloet	Endocrinology	1985	2998738	Yes
3214	1029	1029.0	18.94	18.9	Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation.	Eric C Lai	Nat Genet	2002	11896390	Yes
3215	2058	1029.0	51.46	25.7	Next-generation DNA sequencing.	Jay Shendure, Hanlee Ji	Nat Biotechnol	2008	18846087	Yes
3216	1029	1029.0	28.24	28.2	Recent advances in neuroblastoma.	John M Maris	N Engl J Med	2010	20558371	No
3217	1029	1029.0	0.0	0.0	Connections of the cerebral cortex; the albino rat; topography of the cortical areas.	W J S Krieg	J Comp Neurol	1946	20982805	Yes
3218	2057	1028.5	56.83	28.4	Chlorophyll fluorescence--a practical guide.	K Maxwell, G N Johnson	J Exp Bot	2000	10938857	No
3219	1028	1028.0	0.0	0.0	Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.	J Ott	Am J Hum Genet	1974	4422075	Yes
3220	1028	1028.0	0.0	0.0	Tests for emotionality in rats and mice: a review.	J Archer	Anim Behav	1973	4578750	No
3221	1028	1028.0	43.36	43.4	Toward terminological, conceptual, and statistical clarity in the study of mediators and moderators: examples from the child-clinical and pediatric psychology literatures.	G N Holmbeck	J Consult Clin Psychol	1997	9256561	Yes
3222	1028	1028.0	33.25	33.2	Electrochemical glucose biosensors.	Joseph Wang	Chem Rev	2008	18154363	No
3223	1028	1028.0	26.8	26.8	Tumour necrosis factor and cancer.	Frances Balkwill	Nat Rev Cancer	2009	19343034	No
3224	3083	1027.7	80.58	26.9	Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).	R S Spielman, R E McGinnis, W J Ewens	Am J Hum Genet	1993	8447318	Yes
3225	2055	1027.5	39.97	20.0	Wnt signaling: a common theme in animal development.	K M Cadigan, R Nusse	Genes Dev	1997	9407023	No
3226	1027	1027.0	23.53	23.5	Diffraction methods for biological macromolecules. Interactive computer graphics: FRODO.	T A Jones	Methods Enzymol	1985	3841179	Yes
3227	1027	1027.0	23.98	24.0	Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system.	T Ikemura	J Mol Biol	1981	6175758	Yes
3228	2054	1027.0	74.13	37.1	Social conditions as fundamental causes of disease.	B G Link, J Phelan	J Health Soc Behav	1995	7560851	No
3229	2053	1026.5	53.34	26.7	The regulation and function of c-fos and other immediate early genes in the nervous system.	M Sheng, M E Greenberg	Neuron	1990	1969743	No
3230	1026	1026.0	19.08	19.1	Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions.	W Kolch	Biochem J	2000	11023813	No
3231	1026	1026.0	38.57	38.6	Tumor delivery of macromolecular drugs based on the EPR effect.	Vladimir Torchilin	Adv Drug Deliv Rev	2011	20304019	No
3232	1025	1025.0	18.29	18.3	Molecular mechanisms of axon guidance.	Barry J Dickson	Science	2002	12471249	No
3233	1025	1025.0	26.24	26.2	Context and behavioral processes in extinction.	Mark E Bouton	Learn Mem	2004	15466298	No
3234	1025	1025.0	34.36	34.4	Deconvoluting the context-dependent role for autophagy in cancer.	Eileen White	Nat Rev Cancer	2012	22534666	No
3235	1024	1024.0	32.39	32.4	MOPAC: a semiempirical molecular orbital program.	J J Stewart	J Comput Aided Mol Des	1990	2197373	No
3236	1024	1024.0	55.98	56.0	The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation.	G A Ilizarov	Clin Orthop Relat Res	1989	2910611	Yes
3237	1024	1024.0	0.0	0.0	The influence of immunologically committed lymphoid cells on macrophage activity in vivo.	G B Mackaness	J Exp Med	1969	4976110	Yes
3238	1024	1024.0	38.44	38.4	Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants.	R W Bohannon	Age Ageing	1997	9143432	Yes
3239	1024	1024.0	24.18	24.2	The columnar organization of the neocortex.	V B Mountcastle	Brain	1997	9153131	No
3240	1024	1024.0	20.2	20.2	Progress in human tumour immunology and immunotherapy.	S A Rosenberg	Nature	2001	11357146	No
3241	1023	1023.0	23.39	23.4	Molecular mechanisms of myocardial remodeling.	B Swynghedauw	Physiol Rev	1999	9922372	No
3242	1023	1023.0	0.0	0.0	Regional blood flow by fractional distribution of indicators.	L A Sapirstein	Am J Physiol	1958	13521003	Yes
3243	1023	1023.0	0.0	0.0	The stereotaxic method and radiosurgery of the brain.	L Leksell	Acta Chir Scand	1951	14914373	Yes
3244	1023	1023.0	23.92	23.9	How neutrophils kill microbes.	Anthony W Segal	Annu Rev Immunol	2005	15771570	No
3245	1023	1023.0	30.92	30.9	Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis.	P Vestergaard	Osteoporos Int	2007	17068657	No
3246	1023	1023.0	0.0	0.0	Cell deaths in normal vertebrate ontogeny.	A Glucksmann	Biol Rev Camb Philos Soc	1951	24540363	Yes
3247	2044	1022.0	36.84	18.4	Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain.	W Gu, R G Roeder	Cell	1997	9288740	Yes
3248	1022	1022.0	22.74	22.7	Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution.	Sean B Carroll	Cell	2008	18614008	Yes
3249	1022	1022.0	37.04	37.0	Apoptosis in cancer: from pathogenesis to treatment.	Rebecca S Y Wong	J Exp Clin Cancer Res	2011	21943236	No
3250	2043	1021.5	53.83	26.9	Principles of bioactive lipid signalling: lessons from sphingolipids.	Yusuf A Hannun, Lina M Obeid	Nat Rev Mol Cell Biol	2008	18216770	No
3251	1021	1021.0	55.9	55.9	A "rationalized" arcsine transform.	G A Studebaker	J Speech Hear Res	1985	4046587	Yes
3252	1021	1021.0	0.0	0.0	The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle.	M Jouvet	Ergeb Physiol	1972	4403272	Yes
3253	1021	1021.0	28.84	28.8	Synchronization of cortical activity and its putative role in information processing and learning.	W Singer	Annu Rev Physiol	1993	8466179	No
3254	3063	1021.0	91.69	30.6	Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion.	Robert D Schreiber, Lloyd J Old, Mark J Smyth	Science	2011	21436444	No
3255	2041	1020.5	42.45	21.2	IAP family proteins--suppressors of apoptosis.	Q L Deveraux, J C Reed	Genes Dev	1999	9990849	No
3256	1020	1020.0	29.85	29.9	Animal mitochondrial DNA: structure and evolution.	D R Wolstenholme	Int Rev Cytol	1992	1452431	No
3257	1020	1020.0	0.0	0.0	Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system.	U Ungerstedt	Acta Physiol Scand Suppl	1971	4332694	Yes
3258	4080	1020.0	154.04	38.5	Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials.	K F Schulz, I Chalmers, R J Hayes, D G Altman	JAMA	1995	7823387	Yes
3259	1020	1020.0	46.15	46.1	Coping theory and research: past, present, and future.	R S Lazarus	Psychosom Med	1993	8346332	No
3260	6116	1019.3	167.36	27.9	Prediction of coronary heart disease using risk factor categories.	P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B Kannel	Circulation	1998	9603539	Yes
3261	1019	1019.0	37.53	37.5	Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes.	M A Lemp	CLAO J	1995	8565190	No
3262	1019	1019.0	24.02	24.0	Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis.	Tirion	Phys Rev Lett	1996	10063201	Yes
3263	1019	1019.0	30.07	30.1	Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review.	John W Newcomer	CNS Drugs	2005	15998156	No
3264	3056	1018.7	88.63	29.5	Methods in mammalian autophagy research.	Noboru Mizushima, Tamotsu Yoshimori, Beth Levine	Cell	2010	20144757	Yes
3265	3055	1018.3	79.69	26.6	Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions.	M Piotto, V Saudek, V Sklenár	J Biomol NMR	1992	1490109	Yes
3266	1018	1018.0	28.52	28.5	Presynaptic nicotinic ACh receptors.	S Wonnacott	Trends Neurosci	1997	9023878	No
3267	2036	1018.0	42.23	21.1	Tumour-cell invasion and migration: diversity and escape mechanisms.	Peter Friedl, Katarina Wolf	Nat Rev Cancer	2003	12724734	No
3268	1018	1018.0	30.99	31.0	Stronger Brønsted acids.	Takahiko Akiyama	Chem Rev	2007	17983247	Yes
3269	2036	1018.0	51.76	25.9	Modes of resistance to anti-angiogenic therapy.	Gabriele Bergers, Douglas Hanahan	Nat Rev Cancer	2008	18650835	No
3270	1017	1017.0	29.3	29.3	Hepatitis B virus. The major etiology of hepatocellular carcinoma.	R P Beasley	Cancer	1988	2834034	No
3271	1017	1017.0	21.92	21.9	Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution.	Z Yang	Mol Biol Evol	1998	9580986	Yes
3272	1017	1017.0	25.16	25.2	Quantification of beta-sheet amyloid fibril structures with thioflavin T.	H LeVine	Methods Enzymol	1999	10507030	Yes
3273	1017	1017.0	25.01	25.0	P-450 metabolites of arachidonic acid in the control of cardiovascular function.	Richard J Roman	Physiol Rev	2002	11773611	No
3274	1017	1017.0	0.0	0.0	Simplified Myeloperoxidase Stain Using Benzidine Dihydrochloride.	L S Kaplow	Blood	1965	14332483	Yes
3275	1016	1016.0	53.9	53.9	The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction.	G A Ilizarov	Clin Orthop Relat Res	1989	2912628	Yes
3276	1016	1016.0	50.43	50.4	Analysis of Fickian and non-Fickian drug release from polymers.	N A Peppas	Pharm Acta Helv	1985	4011621	Yes
3277	3048	1016.0	145.48	48.5	Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines.	F Guillemin, C Bombardier, D Beaton	J Clin Epidemiol	1993	8263569	No
3278	1016	1016.0	28.45	28.4	Prostaglandin synthase 2.	H R Herschman	Biochim Biophys Acta	1996	8555245	No
3279	1016	1016.0	28.03	28.0	Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity.	F P Guengerich	Chem Res Toxicol	2001	11409933	No
3280	1016	1016.0	28.28	28.3	The emotional dog and its rational tail: a social intuitionist approach to moral judgment.	J Haidt	Psychol Rev	2001	11699120	Yes
3281	1015	1015.0	24.09	24.1	Natural history of chronic hepatitis C.	Leonard B Seeff	Hepatology	2002	12407575	No
3282	2030	1015.0	63.09	31.5	Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio.	Aluísio J D Barros, Vânia N Hirakata	BMC Med Res Methodol	2003	14567763	Yes
3283	2029	1014.5	43.29	21.6	Genomic control for association studies.	B Devlin, K Roeder	Biometrics	1999	11315092	Yes
3284	1014	1014.0	29.61	29.6	Limbic-cortical dysregulation: a proposed model of depression.	H S Mayberg	J Neuropsychiatry Clin Neurosci	1997	9276848	No
3285	1014	1014.0	22.75	22.8	Epstein-Barr virus infection.	J I Cohen	N Engl J Med	2000	10944566	No
3286	1014	1014.0	26.09	26.1	Mode of action of membrane active antimicrobial peptides.	Yechiel Shai	Biopolymers	2002	12491537	No
3287	1013	1013.0	22.13	22.1	Potential metal-binding domains in nucleic acid binding proteins.	J M Berg	Science	1986	2421409	Yes
3288	1013	1013.0	32.25	32.2	Selective modification of glutathione metabolism.	A Meister	Science	1983	6836290	Yes
3289	1013	1013.0	33.4	33.4	Peritonectomy procedures.	P H Sugarbaker	Ann Surg	1995	7826158	Yes
3290	1013	1013.0	23.36	23.4	New ideas about atrial fibrillation 50 years on.	Stanley Nattel	Nature	2002	11805846	No
3291	1013	1013.0	25.04	25.0	Nonaqueous liquid electrolytes for lithium-based rechargeable batteries.	Kang Xu	Chem Rev	2004	15669157	Yes
3292	1013	1013.0	21.16	21.2	mTOR and cancer: insights into a complex relationship.	David M Sabatini	Nat Rev Cancer	2006	16915295	No
3293	1013	1013.0	23.02	23.0	Phenotypic plasticity and the epigenetics of human disease.	Andrew P Feinberg	Nature	2007	17522677	No
3294	1013	1013.0	44.87	44.9	What is self-rated health and why does it predict mortality? Towards a unified conceptual model.	Marja Jylhä	Soc Sci Med	2009	19520474	Yes
3295	2024	1012.0	77.3	38.6	Visual search and stimulus similarity.	J Duncan, G W Humphreys	Psychol Rev	1989	2756067	Yes
3296	1012	1012.0	31.76	31.8	Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion.	E Falk	Circulation	1985	3971539	Yes
3297	11132	1012.0	331.79	30.2	The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data.	Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristo	Genome Res	2010	20644199	Yes
3298	1012	1012.0	37.18	37.2	Thermal properties of graphene and nanostructured carbon materials.	Alexander A Balandin	Nat Mater	2011	21778997	Yes
3299	4047	1011.8	136.26	34.1	Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin.	W Vale, J Spiess, C Rivier, J Rivier	Science	1981	6267699	Yes
3300	3035	1011.7	158.55	52.9	Assessing coping strategies: a theoretically based approach.	C S Carver, M F Scheier, J K Weintraub	J Pers Soc Psychol	1989	2926629	Yes
3301	8092	1011.5	323.72	40.5	Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey.	R C Kessler, K A McGonagle, S Zhao, C B Nelson, M Hughes, S Eshleman, H U Wittchen, K S Kendler	Arch Gen Psychiatry	1994	8279933	Yes
3302	2023	1011.5	55.62	27.8	Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm.	Subhra K Biswas, Alberto Mantovani	Nat Immunol	2010	20856220	No
3303	1011	1011.0	21.05	21.1	Resolution of phase ambiguity in macromolecular crystallography.	B C Wang	Methods Enzymol	1985	4079800	Yes
3304	1011	1011.0	22.44	22.4	Microsatellites: simple sequences with complex evolution.	Hans Ellegren	Nat Rev Genet	2004	15153996	No
3305	1011	1011.0	31.78	31.8	Species concepts and species delimitation.	Kevin De Queiroz	Syst Biol	2007	18027281	Yes
3306	1010	1010.0	52.66	52.7	The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury.	J A Koufman	Laryngoscope	1991	1895864	No
3307	1010	1010.0	0.0	0.0	Isolation of an organ specific protein antigen from cell-surface membrane of rat liver.	D M Neville	Biochim Biophys Acta	1968	4967807	Yes
3308	1010	1010.0	0.0	0.0	Presidental address. Neuropathological aspects of brain edema.	I Klatzo	J Neuropathol Exp Neurol	1967	5336776	No
3309	1010	1010.0	53.7	53.7	Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem.	P D Henry	Am J Cardiol	1980	6255787	No
3310	2020	1010.0	48.48	24.2	Blinded by the Light: The Growing Complexity of p53.	Karen H Vousden, Carol Prives	Cell	2009	19410540	No
3311	1010	1010.0	84.81	84.8	Understanding Bland Altman analysis.	Davide Giavarina	Biochem Med (Zagreb)	2015	26110027	No
3312	1010	1010.0	85.34	85.3	Metazoan MicroRNAs.	David P Bartel	Cell	2018	29570994	No
3313	2019	1009.5	54.48	27.2	Compilation and analysis of Escherichia coli promoter DNA sequences.	D K Hawley, W R McClure	Nucleic Acids Res	1983	6344016	No
3314	2019	1009.5	80.86	40.4	Functional interactions between the gut microbiota and host metabolism.	Valentina Tremaroli, Fredrik Bäckhed	Nature	2012	22972297	No
3315	3028	1009.3	99.04	33.0	Health benefits of physical activity: the evidence.	Darren E R Warburton, Crystal Whitney Nicol, Shannon S D Bredin	CMAJ	2006	16534088	No
3316	1009	1009.0	26.27	26.3	Automatic quantitation of localized in vivo 1H spectra with LCModel.	S W Provencher	NMR Biomed	2001	11410943	Yes
3317	1009	1009.0	34.15	34.1	Understanding diagnostic tests 3: Receiver operating characteristic curves.	Anthony K Akobeng	Acta Paediatr	2007	17376185	No
3318	1009	1009.0	36.53	36.5	Amino acids: metabolism, functions, and nutrition.	Guoyao Wu	Amino Acids	2009	19301095	No
3319	1009	1009.0	33.72	33.7	MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship.	Amy E Pasquinelli	Nat Rev Genet	2012	22411466	No
3320	2017	1008.5	0.0	0.0	Role of cell shape in growth control.	J Folkman, A Moscona	Nature	1978	661946	Yes
3321	2017	1008.5	60.74	30.4	The capacity of visual working memory for features and conjunctions.	S J Luck, E K Vogel	Nature	1997	9384378	Yes
3322	1008	1008.0	28.98	29.0	Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease.	W J Welch	Physiol Rev	1992	1438579	No
3323	1008	1008.0	34.93	34.9	Lipid peroxidation and antioxidants as biomarkers of tissue damage.	J M Gutteridge	Clin Chem	1995	7497639	No
3324	1008	1008.0	22.02	22.0	Oxidant signals and oxidative stress.	Toren Finkel	Curr Opin Cell Biol	2003	12648682	No
3325	1008	1008.0	21.12	21.1	Telomeres and human disease: ageing, cancer and beyond.	Maria A Blasco	Nat Rev Genet	2005	16136653	No
3326	3022	1007.3	0.0	0.0	Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose.	P L Ey, S J Prowse, C R Jenkin	Immunochemistry	1978	30693	Yes
3327	1007	1007.0	35.53	35.5	Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance.	M D Majewska	Prog Neurobiol	1992	1349441	No
3328	3021	1007.0	62.51	20.8	The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.	W H Landschulz, P F Johnson, S L McKnight	Science	1988	3289117	Yes
3329	2014	1007.0	46.68	23.3	Obesity and insulin resistance.	B B Kahn, J S Flier	J Clin Invest	2000	10953022	No
3330	1007	1007.0	21.45	21.4	Osmotic stress signaling and osmoadaptation in yeasts.	Stefan Hohmann	Microbiol Mol Biol Rev	2002	12040128	No
3331	2013	1006.5	47.54	23.8	Cellular uptake of the tat protein from human immunodeficiency virus.	A D Frankel, C O Pabo	Cell	1988	2849510	Yes
3332	4026	1006.5	105.74	26.4	A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V.	I Vermes, C Haanen, H Steffens-Nakken, C Reutelingsperger	J Immunol Methods	1995	7622868	Yes
3333	3018	1006.0	0.0	0.0	Depression: a new animal model sensitive to antidepressant treatments.	R D Porsolt, M Le Pichon, M Jalfre	Nature	1977	559941	Yes
3334	1006	1006.0	28.18	28.2	The role of protein phosphorylation in neural and hormonal control of cellular activity.	P Cohen	Nature	1982	6280056	No
3335	3018	1006.0	61.29	20.4	Genetic instabilities in human cancers.	C Lengauer, K W Kinzler, B Vogelstein	Nature	1998	9872311	No
3336	1006	1006.0	0.0	0.0	Motivation reconsidered: the concept of competence.	R W White	Psychol Rev	1959	13844397	Yes
3337	6036	1006.0	193.95	32.3	Prevalence of overweight and obesity in the United States, 1999-2004.	Cynthia L Ogden, Margaret D Carroll, Lester R Curtin, Margaret A McDowell, Carolyn J Tabak, Katherine M Flegal	JAMA	2006	16595758	Yes
3338	2012	1006.0	127.23	63.6	mTOR Signaling in Growth, Metabolism, and Disease.	Robert A Saxton, David M Sabatini	Cell	2017	28283069	No
3339	2010	1005.0	0.0	0.0	Analysis of probability as an aid in the clinical diagnosis of coronary-artery disease.	G A Diamond, J S Forrester	N Engl J Med	1979	440357	Yes
3340	1005	1005.0	17.5	17.5	Functional inactivation of genes by dominant negative mutations.	I Herskowitz	Nature	1987	2442619	No
3341	1005	1005.0	0.0	0.0	Vagal sensory receptors and their reflex effects.	A S Paintal	Physiol Rev	1973	4568412	No
3342	1005	1005.0	34.6	34.6	Why we need observational studies to evaluate the effectiveness of health care.	N Black	BMJ	1996	8634569	Yes
3343	3015	1005.0	73.82	24.6	Photodynamic therapy for cancer.	Dennis E J G J Dolmans, Dai Fukumura, Rakesh K Jain	Nat Rev Cancer	2003	12724736	No
3344	1005	1005.0	24.18	24.2	The tumor microenvironment and its role in promoting tumor growth.	T L Whiteside	Oncogene	2008	18836471	No
3345	1005	1005.0	0.0	0.0	Histological and histochemical uses of periodic acid.	J F A McMANUS	Stain Technol	1948	18867618	Yes
3346	2009	1004.5	40.5	20.2	The druggable genome.	Andrew L Hopkins, Colin R Groom	Nat Rev Drug Discov	2002	12209152	No
3347	1004	1004.0	38.6	38.6	The ovariectomized rat model of postmenopausal bone loss.	D N Kalu	Bone Miner	1991	1773131	No
3348	2008	1004.0	76.39	38.2	The Modified Mini-Mental State (3MS) examination.	E L Teng, H C Chui	J Clin Psychiatry	1987	3611032	Yes
3349	1004	1004.0	26.88	26.9	The potential environmental impact of engineered nanomaterials.	Vicki L Colvin	Nat Biotechnol	2003	14520401	Yes
3350	1004	1004.0	24.97	25.0	Anatomy and regulation of the central melanocortin system.	Roger D Cone	Nat Neurosci	2005	15856065	No
3351	4015	1003.8	0.0	0.0	Coated charcoal immunoassay of insulin.	V Herbert, K S Lau, C W Gottlieb, S J Bleicher	J Clin Endocrinol Metab	1965	5320561	Yes
3352	5016	1003.2	104.46	20.9	Electrostatics of nanosystems: application to microtubules and the ribosome.	N A Baker, D Sept, S Joseph, M J Holst, J A McCammon	Proc Natl Acad Sci U S A	2001	11517324	Yes
3353	1003	1003.0	28.05	28.1	Epidemiology of women and depression.	Ronald C Kessler	J Affect Disord	2003	12646294	Yes
3354	3007	1002.3	65.08	21.7	TGF-beta signalling from cell membrane to nucleus through SMAD proteins.	C H Heldin, K Miyazono, P ten Dijke	Nature	1997	9393997	No
3355	2004	1002.0	91.37	45.7	Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics.	J B Mulliken, J Glowacki	Plast Reconstr Surg	1982	7063565	Yes
3356	2004	1002.0	52.8	26.4	Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2.	M Tsujii, R N DuBois	Cell	1995	8521479	Yes
3357	1002	1002.0	25.86	25.9	Molten globule and protein folding.	O B Ptitsyn	Adv Protein Chem	1995	8561052	No
3358	2003	1001.5	84.59	42.3	Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications.	L A Clark, D Watson	J Abnorm Psychol	1991	1918611	No
3359	1001	1001.0	29.7	29.7	Cytochrome oxidase: an endogenous metabolic marker for neuronal activity.	M T Wong-Riley	Trends Neurosci	1989	2469224	No
3360	1001	1001.0	28.48	28.5	Intermediate filaments: a chemically heterogeneous, developmentally regulated class of proteins.	E Lazarides	Annu Rev Biochem	1982	6180679	No
3361	1001	1001.0	33.93	33.9	A practical computer-based approach to the analysis of radioligand binding experiments.	G A McPherson	Comput Programs Biomed	1983	6319079	Yes
3362	1001	1001.0	26.15	26.1	Comparative physiology of salt and water stress.	R. Munns	Plant Cell Environ	2002	11841667	Yes
3363	1001	1001.0	25.31	25.3	Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures.	Frank Würthner	Chem Commun (Camb)	2004	15263926	Yes
3364	1001	1001.0	83.98	84.0	Making sense of implementation theories, models and frameworks.	Per Nilsen	Implement Sci	2015	25895742	Yes
3365	2001	1000.5	54.9	27.4	Epidemiology of Parkinson's disease.	Lonneke M L de Lau, Monique M B Breteler	Lancet Neurol	2006	16713924	No
3366	7003	1000.4	213.69	30.5	Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.	H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E Marsh	Stroke	1993	7678184	Yes
3367	2000	1000.0	50.97	25.5	ZINC--a free database of commercially available compounds for virtual screening.	John J Irwin, Brian K Shoichet	J Chem Inf Model	2005	15667143	Yes
3368	1000	1000.0	0.0	0.0	The Stability of Broken Ends of Chromosomes in Zea Mays.	B McClintock	Genetics	1941	17247004	Yes
3369	999	999.0	29.62	29.6	Classes of calcium channels in vertebrate cells.	B P Bean	Annu Rev Physiol	1989	2540697	No
3370	999	999.0	48.76	48.8	Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder.	M Rutter	Br J Psychiatry	1985	3830321	Yes
3371	999	999.0	24.4	24.4	Personal genomes: The case of the missing heritability.	Brendan Maher	Nature	2008	18987709	No
3372	1996	998.0	42.2	21.1	Community structure in social and biological networks.	M Girvan, M E J Newman	Proc Natl Acad Sci U S A	2002	12060727	No
3373	998	998.0	19.47	19.5	DNA methylation in cancer: too much, but also too little.	Melanie Ehrlich	Oncogene	2002	12154403	No
3374	998	998.0	27.93	27.9	TNF-mediated inflammatory disease.	J R Bradley	J Pathol	2008	18161752	No
3375	998	998.0	22.42	22.4	Up on the tightrope: natural killer cell activation and inhibition.	Lewis L Lanier	Nat Immunol	2008	18425106	No
3376	2993	997.7	83.57	27.9	A nonparametric method for automatic correction of intensity nonuniformity in MRI data.	J G Sled, A P Zijdenbos, A C Evans	IEEE Trans Med Imaging	1998	9617910	Yes
3377	7980	997.5	233.5	29.2	A method and server for predicting damaging missense mutations.	Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R Sunyaev	Nat Methods	2010	20354512	Yes
3378	997	997.0	0.0	0.0	Serine proteases: structure and mechanism of catalysis.	J Kraut	Annu Rev Biochem	1977	332063	No
3379	997	997.0	0.0	0.0	Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address.	E C Miller	Cancer Res	1978	348302	No
3380	997	997.0	49.64	49.6	Self-discrepancy: a theory relating self and affect.	E T Higgins	Psychol Rev	1987	3615707	Yes
3381	997	997.0	40.97	41.0	Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin.	R J Cousins	Physiol Rev	1985	3885271	No
3382	1994	997.0	106.96	53.5	3D bioprinting of tissues and organs.	Sean V Murphy, Anthony Atala	Nat Biotechnol	2014	25093879	Yes
3383	5980	996.7	163.15	27.2	An obesity-associated gut microbiome with increased capacity for energy harvest.	Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I Gordon	Nature	2006	17183312	Yes
3384	996	996.0	23.09	23.1	Telomere loss: mitotic clock or genetic time bomb?	C B Harley	Mutat Res	1991	1722017	No
3385	996	996.0	27.29	27.3	The molecular biology and functions of the granulocyte-macrophage colony-stimulating factors.	D Metcalf	Blood	1986	3002522	No
3386	1992	996.0	59.37	29.7	Glycoprotein hormones: structure and function.	J G Pierce, T F Parsons	Annu Rev Biochem	1981	6267989	No
3387	1992	996.0	48.3	24.1	Regulation of wound healing by growth factors and cytokines.	Sabine Werner, Richard Grose	Physiol Rev	2003	12843410	No
3388	996	996.0	22.79	22.8	Membrane recognition by phospholipid-binding domains.	Mark A Lemmon	Nat Rev Mol Cell Biol	2008	18216767	No
3389	1991	995.5	64.96	32.5	Health effects of fine particulate air pollution: lines that connect.	C Arden Pope, Douglas W Dockery	J Air Waste Manag Assoc	2006	16805397	No
3390	1990	995.0	0.0	0.0	Fine structural localization of a blood-brain barrier to exogenous peroxidase.	T S Reese, M J Karnovsky	J Cell Biol	1967	6033532	Yes
3391	995	995.0	56.77	56.8	Calcium phosphate ceramics as hard tissue prosthetics.	M Jarcho	Clin Orthop Relat Res	1981	7018783	No
3392	995	995.0	36.33	36.3	Methods for dealing with reaction time outliers.	R Ratcliff	Psychol Bull	1993	8272468	Yes
3393	1990	995.0	40.28	20.1	Cellular functions regulated by Src family kinases.	S M Thomas, J S Brugge	Annu Rev Cell Dev Biol	1997	9442882	No
3394	995	995.0	50.7	50.7	Environmentally induced oxidative stress in aquatic animals.	Volodymyr I Lushchak	Aquat Toxicol	2011	21074869	No
3395	995	995.0	28.78	28.8	Molecular genetics of colorectal cancer.	Eric R Fearon	Annu Rev Pathol	2011	21090969	No
3396	995	995.0	49.75	49.8	Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'.	Konrad M Andrassy	Kidney Int	2013	23989362	Yes
3397	2984	994.7	73.93	24.6	Nitric oxide and macrophage function.	J MacMicking, Q W Xie, C Nathan	Annu Rev Immunol	1997	9143691	No
3398	1989	994.5	0.0	0.0	A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants.	G C Liggins, R N Howie	Pediatrics	1972	4561295	Yes
3399	1989	994.5	0.0	0.0	The period of susceptibility to the physiological effects of unilateral eye closure in kittens.	D H Hubel, T N Wiesel	J Physiol	1970	5498493	Yes
3400	994	994.0	23.88	23.9	The prefrontal cortex--an update: time is of the essence.	J M Fuster	Neuron	2001	11394996	No
3401	994	994.0	0.0	0.0	Differential spectrophotometry of purine compounds by means of specific enzymes; determination of hydroxypurine compounds.	H M Kalckar	J Biol Chem	1947	20285039	Yes
3402	1987	993.5	75.83	37.9	Understanding face recognition.	V Bruce, A Young	Br J Psychol	1986	3756376	Yes
3403	1987	993.5	68.54	34.3	Inflammatory mechanisms in obesity.	Margaret F Gregor, Gökhan S Hotamisligil	Annu Rev Immunol	2011	21219177	No
3404	1986	993.0	47.5	23.8	p53 function and dysfunction.	B Vogelstein, K W Kinzler	Cell	1992	1505019	No
3405	993	993.0	21.6	21.6	Nucleic acid junctions and lattices.	N C Seeman	J Theor Biol	1982	6188926	Yes
3406	993	993.0	0.0	0.0	Histiocytosis X; integration of eosinophilic granuloma of bone, Letterer-Siwe disease, and Schüller-Christian disease as related manifestations of a single nosologic entity.	L Lichtenstein	AMA Arch Pathol	1953	13057466	Yes
3407	993	993.0	24.92	24.9	Nitric oxide, oxidants, and protein tyrosine nitration.	Rafael Radi	Proc Natl Acad Sci U S A	2004	15020765	Yes
3408	993	993.0	43.2	43.2	The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles.	Eleonore Fröhlich	Int J Nanomedicine	2012	23144561	No
3409	1984	992.0	53.56	26.8	Humans integrate visual and haptic information in a statistically optimal fashion.	Marc O Ernst, Martin S Banks	Nature	2002	11807554	Yes
3410	1984	992.0	46.1	23.1	Regeneration beyond the glial scar.	Jerry Silver, Jared H Miller	Nat Rev Neurosci	2004	14735117	No
3411	992	992.0	25.66	25.7	Solid-state nanopores.	Cees Dekker	Nat Nanotechnol	2007	18654264	No
3412	1983	991.5	37.61	18.8	Signal transduction by lymphocyte antigen receptors.	A Weiss, D R Littman	Cell	1994	8293463	No
3413	1983	991.5	44.9	22.4	Caspases: killer proteases.	D W Nicholson, N A Thornberry	Trends Biochem Sci	1997	9270303	No
3414	1983	991.5	41.23	20.6	Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm.	P E Wright, H J Dyson	J Mol Biol	1999	10550212	No
3415	3966	991.5	97.75	24.4	MEGA2: molecular evolutionary genetics analysis software.	S Kumar, K Tamura, I B Jakobsen, M Nei	Bioinformatics	2001	11751241	Yes
3416	4957	991.4	152.8	30.6	The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells.	R Moll, W W Franke, D L Schiller, B Geiger, R Krepler	Cell	1982	6186379	No
3417	5947	991.2	158.32	26.4	Ghrelin is a growth-hormone-releasing acylated peptide from stomach.	M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K Kangawa	Nature	1999	10604470	Yes
3418	991	991.0	31.44	31.4	Topography of cognition: parallel distributed networks in primate association cortex.	P S Goldman-Rakic	Annu Rev Neurosci	1988	3284439	No
3419	991	991.0	37.66	37.7	Cellular mechanisms of muscle fatigue.	R H Fitts	Physiol Rev	1994	8295935	No
3420	991	991.0	19.71	19.7	Initiation of translation in prokaryotes and eukaryotes.	M Kozak	Gene	1999	10395892	No
3421	991	991.0	30.75	30.8	Spatially heterogeneous dynamics in supercooled liquids.	M D Ediger	Annu Rev Phys Chem	2000	11031277	Yes
3422	991	991.0	28.88	28.9	Riddle of biofilm resistance.	K Lewis	Antimicrob Agents Chemother	2001	11257008	No
3423	1981	990.5	72.9	36.5	Origins and evolution of antibiotic resistance.	Julian Davies, Dorothy Davies	Microbiol Mol Biol Rev	2010	20805405	No
3424	6933	990.4	186.55	26.7	Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.	R K Saiki, S Scharf, F Faloona, K B Mullis, G T Horn, H A Erlich, N Arnheim	Science	1985	2999980	Yes
3425	3960	990.0	94.73	23.7	The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis.	R M Kluck, E Bossy-Wetzel, D R Green, D D Newmeyer	Science	1997	9027315	Yes
3426	990	990.0	0.0	0.0	Pelvic Scoring For Elective Induction.	E H Bishop	Obstet Gynecol	1964	14199536	Yes
3427	990	990.0	21.56	21.6	Fibrotic disease and the T(H)1/T(H)2 paradigm.	Thomas A Wynn	Nat Rev Immunol	2004	15286725	No
3428	990	990.0	37.33	37.3	Electrocatalyst approaches and challenges for automotive fuel cells.	Mark K Debe	Nature	2012	22678278	Yes
3429	1979	989.5	0.0	0.0	Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats.	M J Mulvany, W Halpern	Circ Res	1977	862138	Yes
3430	1979	989.5	59.47	29.7	Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis.	C N Hales, D J Barker	Diabetologia	1992	1644236	No
3431	1979	989.5	0.0	0.0	Maximum utilization of the life table method in analyzing survival.	S J Cutler, F Ederer	J Chronic Dis	1958	13598782	Yes
3432	1978	989.0	0.0	0.0	Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.	S Ohkuma, B Poole	Proc Natl Acad Sci U S A	1978	28524	Yes
3433	989	989.0	15.87	15.9	Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast.	L Guarente	Methods Enzymol	1983	6310321	Yes

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