Unicorn Papers

Top ‱ cited papers from PUBMED

Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authors
Currently, the list contains 3419 papers with ECcit ≥ 986.5
‱ - permyriad, , literally meaning "for (every) myriad (ten thousand)"

Volume 11, July 2021

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No. Citations ECcit RCR ECRCR Title Authors Journal Year PMID Article(?)
1220948220948.00.00.0Cleavage of structural proteins during the assembly of the head of bacteriophage T4. U K LaemmliNature19705432063Yes
2167634167634.00.00.0A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. M M BradfordAnal Biochem1976942051Yes
328879472198.50.00.0Protein measurement with the Folin phenol reagent. O H Lowry, N J Rosebrough, A L Farr, R J RandallJ Biol Chem195114907713Yes
49225846129.02386.91193.5Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. K J Livak, T D SchmittgenMethods200111846609Yes
54264842648.01464.321464.3A short history of SHELX. George M SheldrickActa Crystallogr A200818156677Yes
63310133101.01072.051072.0Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. T MosmannJ Immunol Methods19836606682Yes
76525132625.51976.82988.4Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. P Chomczynski, N SacchiAnal Biochem19872440339Yes
83014530145.00.00.0Detection of specific sequences among DNA fragments separated by gel electrophoresis. E M SouthernJ Mol Biol19751195397Yes
92487924879.00.00.0The assessment and analysis of handedness: the Edinburgh inventory. R C OldfieldNeuropsychologia19715146491Yes
102430624306.0567.86567.9MicroRNAs: genomics, biogenesis, mechanism, and function. David P BartelCell200414744438No
112323723237.00.00.0A rating scale for depression. M HamiltonJ Neurol Neurosurg Psychiatry196014399272Yes
122191921919.0687.54687.5Confidence Limits On Phylogenies: An Approach Using The Bootstrap. Joseph FelsensteinEvolution198528561359Yes
136521321737.70.00.0DNA sequencing with chain-terminating inhibitors. F Sanger, S Nicklen, A R CoulsonProc Natl Acad Sci U S A1977271968Yes
142091620916.0500.81500.8A new mathematical model for relative quantification in real-time RT-PCR. M W PfafflNucleic Acids Res200111328886Yes
152078720787.0522.81522.8MUSCLE: multiple sequence alignment with high accuracy and high throughput. Robert C EdgarNucleic Acids Res200415034147Yes
161987419874.00.00.0The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. E S ReynoldsJ Cell Biol196313986422Yes
175909119697.00.00.0"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. M F Folstein, S E Folstein, P R McHughJ Psychiatr Res19751202204Yes
183621918109.51120.67560.3The neighbor-joining method: a new method for reconstructing phylogenetic trees. N Saitou, M NeiMol Biol Evol19873447015Yes
191783717837.00.00.0Tissue sulfhydryl groups. G L EllmanArch Biochem Biophys195913650640Yes
205306317687.70.00.0Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. H Towbin, T Staehelin, J GordonProc Natl Acad Sci U S A1979388439Yes
211682216822.00.00.0Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins. B J DavisAnn N Y Acad Sci196414240539Yes
221679816798.00.00.0High resolution two-dimensional electrophoresis of proteins. P H O'FarrellJ Biol Chem1975236308Yes
233312016560.01609.45804.7Statistical methods for assessing agreement between two methods of clinical measurement. J M Bland, D G AltmanLancet19862868172Yes
241595215952.0567.8567.8Density-functional exchange-energy approximation with correct asymptotic behavior. BeckePhys Rev A Gen Phys19889900728Yes
251594215942.0418.69418.7Atherosclerosis--an inflammatory disease. R RossN Engl J Med19999887164No
261589915899.00.00.0A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. K BurtonBiochem J195613293190Yes
273071315356.51121.38560.7Hallmarks of cancer: the next generation. Douglas Hanahan, Robert A WeinbergCell201121376230No
283028415142.00.00.0A rapid method of total lipid extraction and purification. E G Bligh, W J DyerCan J Biochem Physiol195913671378Yes
291502615026.0560.48560.5A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. M KimuraJ Mol Evol19807463489Yes
302873214366.00.00.0The measurement of observer agreement for categorical data. J R Landis, G G KochBiometrics1977843571Yes
314300314334.31239.9413.3CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. J D Thompson, D G Higgins, T J GibsonNucleic Acids Res19947984417Yes
324167513891.70.00.0A simple method for the isolation and purification of total lipides from animal tissues. J Folch, M Lees, G H Sloane StanleyJ Biol Chem195713428781Yes
331308313083.0367.1367.1MicroRNAs: target recognition and regulatory functions. David P BartelCell200919167326No
341284512845.00.00.0Phosphorus assay in column chromatography. G R BartlettJ Biol Chem195913641241Yes
351262312623.0537.69537.7A power primer. J CohenPsychol Bull199219565683Yes
362493812469.0965.08482.5Meta-analysis in clinical trials. R DerSimonian, N LairdControl Clin Trials19863802833Yes
372427112135.51016.42508.2The hospital anxiety and depression scale. A S Zigmond, R P SnaithActa Psychiatr Scand19836880820Yes
381212712127.0362.13362.1Projector augmented-wave method. BlöchlPhys Rev B Condens Matter19949976227Yes
391169311693.0465.22465.2Catalase in vitro. H AebiMethods Enzymol19846727660Yes
402184410922.0932.68466.3The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. J E Ware, C D SherbourneMed Care19921593914Yes
415429910859.81570.96314.2Basic local alignment search tool. S F Altschul, W Gish, W Miller, E W Myers, D J LipmanJ Mol Biol19902231712Yes
422155010775.0559.37279.7A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. A P Feinberg, B VogelsteinAnal Biochem19836312838Yes
431076910769.0590.89590.9RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Alexandros StamatakisBioinformatics201424451623Yes
442105910529.5471.07235.5Coot: model-building tools for molecular graphics. Paul Emsley, Kevin CowtanActa Crystallogr D Biol Crystallogr200415572765Yes
453130810436.0981.17327.1Generalized Gradient Approximation Made Simple. Perdew, Burke, ErnzerhofPhys Rev Lett199610062328Yes
461030610306.00.00.0Improvements in epoxy resin embedding methods. J H LuftJ Biophys Biochem Cytol196113764136Yes
471016510165.0344.26344.3Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). J F KurtzkeNeurology19836685237Yes
482012310061.50.00.0The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. K Weber, M OsbornJ Biol Chem19695806584Yes
4999879987.0400.69400.7Structure validation in chemical crystallography. Anthony L SpekActa Crystallogr D Biol Crystallogr200919171970Yes
5098919891.00.00.0The genetics of Caenorhabditis elegans. S BrennerGenetics19744366476Yes
51195679783.5555.13277.6Fast and accurate short read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics200919451168Yes
5297189718.0302.47302.5The Psychophysics Toolbox. D H BrainardSpat Vis19979176952Yes
53193809690.0438.8219.4[20] Processing of X-ray diffraction data collected in oscillation mode. Zbyszek Otwinowski, Wladek MinorMethods Enzymol199727799103Yes
54289539651.01061.59353.9Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. Lee, Yang, ParrPhys Rev B Condens Matter19889944570Yes
5594409440.0355.28355.3Search and clustering orders of magnitude faster than BLAST. Robert C EdgarBioinformatics201020709691Yes
5694159415.00.00.0Self-efficacy: toward a unifying theory of behavioral change. A BanduraPsychol Rev1977847061Yes
5794139413.0324.35324.4Banting lecture 1988. Role of insulin resistance in human disease. G M ReavenDiabetes19883056758No
5893129312.0275.48275.5Xds. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124692Yes
5992479247.0269.16269.2Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. P S ThomasProc Natl Acad Sci U S A19806159641Yes
6090189018.0240.03240.0Studies on transformation of Escherichia coli with plasmids. D HanahanJ Mol Biol19836345791Yes
61180309015.0473.91237.0A simple method for displaying the hydropathic character of a protein. J Kyte, R F DoolittleJ Mol Biol19827108955Yes
6290139013.0260.13260.1The pathogenesis of atherosclerosis: a perspective for the 1990s. R RossNature19938479518No
6389148914.0235.28235.3Integrins: versatility, modulation, and signaling in cell adhesion. R O HynesCell19921555235No
6488848884.0352.09352.1A new method for measuring daytime sleepiness: the Epworth sleepiness scale. M W JohnsSleep19911798888Yes
65177278863.5809.79404.9The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. R M Baron, D A KennyJ Pers Soc Psychol19863806354Yes
66176958847.5669.3334.6Fast gapped-read alignment with Bowtie 2. Ben Langmead, Steven L SalzbergNat Methods201222388286Yes
6783978397.0186.5186.5Mfold web server for nucleic acid folding and hybridization prediction. Michael ZukerNucleic Acids Res200312824337Yes
68167668383.0479.68239.8Quantifying heterogeneity in a meta-analysis. Julian P T Higgins, Simon G ThompsonStat Med200212111919Yes
6983438343.0599.09599.1Crystal structure refinement with SHELXL. George M SheldrickActa Crystallogr C Struct Chem201525567568Yes
7082918291.0236.79236.8Evolutionary trees from DNA sequences: a maximum likelihood approach. J FelsensteinJ Mol Evol19817288891Yes
7182618261.0231.54231.5RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. Alexandros StamatakisBioinformatics200616928733Yes
7281078107.0259.56259.6Vitamin D deficiency. Michael F HolickN Engl J Med200717634462No
7380828082.00.00.0On the origin of cancer cells. O WarburgScience195613298683Yes
7480158015.0173.68173.7Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Gordon K SmythStat Appl Genet Mol Biol200416646809Yes
75159457972.5351.29175.6The hallmarks of cancer. D Hanahan, R A WeinbergCell200010647931No
7679697969.00.00.0Solvent content of protein crystals. B W MatthewsJ Mol Biol19685700707Yes
77156837841.5461.31230.7Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. Kresse, FurthmüllerPhys Rev B Condens Matter19969984901Yes
7878107810.0353.29353.3Psychophysical bases of perceived exertion. G A BorgMed Sci Sports Exerc19827154893Yes
7977597759.0218.2218.2The role of protein kinase C in cell surface signal transduction and tumour promotion. Y NishizukaNature19846232463No
8077217721.0217.67217.7"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. W N BurnetteAnal Biochem19816266278Yes
81230647688.0618.63206.2VMD: visual molecular dynamics. W Humphrey, A Dalke, K SchultenJ Mol Graph19968744570Yes
8276617661.00.00.0A simplification of the protein assay method of Lowry et al. which is more generally applicable. G L PetersonAnal Biochem1977603028Yes
8375957595.0170.17170.2The functions of animal microRNAs. Victor AmbrosNature200415372042No
8475587558.00.00.0Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. J R VaneNat New Biol19715284360Yes
85301567539.0922.0230.5Measuring inconsistency in meta-analyses. Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G AltmanBMJ200312958120No
8673727372.00.00.0Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris. D I ArnonPlant Physiol194916654194Yes
8773007300.0200.25200.2Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. M C HochbergArthritis Rheum19979324032Yes
88144827241.0346.6173.3Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Kazutoshi Takahashi, Shinya YamanakaCell200616904174Yes
8972187218.00.00.0A low-viscosity epoxy resin embedding medium for electron microscopy. A R SpurrJ Ultrastruct Res19694887011Yes
9071377137.0212.29212.3Semiempirical GGA-type density functional constructed with a long-range dispersion correction. Stefan GrimmeJ Comput Chem200616955487Yes
91281997049.81090.5272.6A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. M E Charlson, P Pompei, K L Ales, C R MacKenzieJ Chronic Dis19873558716Yes
9270177017.00.00.0Tumor angiogenesis: therapeutic implications. J FolkmanN Engl J Med19714938153No
9369896989.0194.19194.2TreeView: an application to display phylogenetic trees on personal computers. R D PageComput Appl Biosci19968902363Yes
9469886988.00.00.0Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. A BöyumScand J Clin Lab Invest Suppl19684179068Yes
95209196973.0602.51200.8Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Da Wei Huang, Brad T Sherman, Richard A LempickiNat Protoc200919131956Yes
96138976948.5355.6177.8MrBayes 3: Bayesian phylogenetic inference under mixed models. Fredrik Ronquist, John P HuelsenbeckBioinformatics200312912839Yes
9768636863.00.00.0The thiobarbituric acid assay of sialic acids. L WarrenJ Biol Chem195913672998Yes
98205666855.30.00.0Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. W T Friedewald, R I Levy, D S FredricksonClin Chem19724337382Yes
99204686822.7585.52195.2A new generation of Ca2+ indicators with greatly improved fluorescence properties. G Grynkiewicz, M Poenie, R Y TsienJ Biol Chem19853838314Yes
100477266818.01266.97181.0Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J LipmanNucleic Acids Res19979254694No
10167296729.0183.32183.3The steroid and thyroid hormone receptor superfamily. R M EvansScience19883283939No
10267006700.0204.85204.8AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. R W CoxComput Biomed Res19968812068Yes
103133826691.00.00.0Continuous cultures of fused cells secreting antibody of predefined specificity. G Köhler, C MilsteinNature19751172191Yes
104264416610.2886.95221.7Bias in meta-analysis detected by a simple, graphical test. M Egger, G Davey Smith, M Schneider, C MinderBMJ19979310563Yes
105132206610.0286.94143.5 Processing of X-ray diffraction data collected in oscillation mode. Z Otwinowski, W MinorMethods Enzymol199727754618Yes
106263596589.81163.84291.0Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanPLoS Med200919621072No
10765856585.0154.49154.5Chromatin modifications and their function. Tony KouzaridesCell200717320507No
10865826582.0177.13177.1Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. F TajimaGenetics19892513255Yes
109130616530.5379.77189.9Analyzing real-time PCR data by the comparative C(T) method. Thomas D Schmittgen, Kenneth J LivakNat Protoc200818546601Yes
110194796493.0783.58261.2NIH Image to ImageJ: 25 years of image analysis. Caroline A Schneider, Wayne S Rasband, Kevin W EliceiriNat Methods201222930834No
11164836483.0172.64172.6Adhesion receptors of the immune system. T A SpringerNature19901974032No
11264696469.0227.6227.6The blockade of immune checkpoints in cancer immunotherapy. Drew M PardollNat Rev Cancer201222437870No
11364326432.0309.53309.5Comparative fit indexes in structural models. P M BentlerPsychol Bull19902320703Yes
11464296429.0169.95169.9PAML 4: phylogenetic analysis by maximum likelihood. Ziheng YangMol Biol Evol200717483113Yes
11563816381.0257.85257.9Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Andreas StangEur J Epidemiol201020652370Yes
11663576357.0175.33175.3Canonical dynamics: Equilibrium phase-space distributions. HooverPhys Rev A Gen Phys19859895674Yes
11763466346.0169.07169.1Angiogenesis in cancer, vascular, rheumatoid and other disease. J FolkmanNat Med19957584949No
118126926346.0294.19147.1Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. S J Clough, A F BentPlant J199810069079Yes
11963456345.0129.51129.5Rapid and efficient site-specific mutagenesis without phenotypic selection. T A KunkelProc Natl Acad Sci U S A19853881765Yes
120125976298.50.00.0Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Y Cheng, W H PrusoffBiochem Pharmacol19734202581Yes
12162906290.00.00.0The assessment of anxiety states by rating. M HamiltonBr J Med Psychol195913638508Yes
12262436243.0163.3163.3Fast robust automated brain extraction. Stephen M SmithHum Brain Mapp200212391568No
123124426221.00.00.0Statistical aspects of the analysis of data from retrospective studies of disease. N Mantel, W HaenszelJ Natl Cancer Inst195913655060Yes
12461696169.0192.13192.1The VideoToolbox software for visual psychophysics: transforming numbers into movies. D G PelliSpat Vis19979176953Yes
12561626162.0210.76210.8Density-functional approximation for the correlation energy of the inhomogeneous electron gas. PerdewPhys Rev B Condens Matter19869938299Yes
12661226122.0204.55204.6Ethical guidelines for investigations of experimental pain in conscious animals. Manfred ZimmermannPain19836877845No
12761206120.0135.72135.7p53, the cellular gatekeeper for growth and division. A J LevineCell19979039259No
128121716085.50.00.0A rapid alkaline extraction procedure for screening recombinant plasmid DNA. H C Birnboim, J DolyNucleic Acids Res1979388356Yes
129181956065.0835.67278.6Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Michael I Love, Wolfgang Huber, Simon AndersGenome Biol201425516281Yes
13060066006.0149.88149.9Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. T A SpringerCell19947507411No
131239695992.20.00.0Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. J M Chirgwin, A E Przybyla, R J MacDonald, W J RutterBiochemistry1979518835Yes
13259335933.0171.25171.2Apoptosis: a review of programmed cell death. Susan ElmoreToxicol Pathol200717562483No
13359255925.0152.22152.2Inositol trisphosphate and calcium signalling. M J BerridgeNature19938381210No
134118115905.5263.88131.9KEGG: kyoto encyclopedia of genes and genomes. M Kanehisa, S GotoNucleic Acids Res200010592173Yes
13559045904.0151.99152.0G proteins: transducers of receptor-generated signals. A G GilmanAnnu Rev Biochem19873113327No
136117725886.00.00.0Prediction of creatinine clearance from serum creatinine. D W Cockcroft, M H GaultNephron19761244564Yes
13757745774.0121.13121.1Integrins: bidirectional, allosteric signaling machines. Richard O HynesCell200212297042No
13857575757.0190.51190.5The Clinical Dementia Rating (CDR): current version and scoring rules. J C MorrisNeurology19938232972Yes
139115075753.50.00.0The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature. T Omura, R SatoJ Biol Chem196414209971Yes
14057455745.0133.13133.1Inflammation in atherosclerosis. Peter LibbyNature200212490960No
141114535726.5545.18272.6MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Kazutaka Katoh, Daron M StandleyMol Biol Evol201323329690Yes
142113935696.50.00.0Intraclass correlations: uses in assessing rater reliability. P E Shrout, J L FleissPsychol Bull197918839484No
14356425642.0144.06144.1Inflammation, atherosclerosis, and coronary artery disease. Göran K HanssonN Engl J Med200515843671No
14456185618.0144.47144.5Apoptosis in the pathogenesis and treatment of disease. C B ThompsonScience19957878464No
145111415570.5399.09199.5The meaning and use of the area under a receiver operating characteristic (ROC) curve. J A Hanley, B J McNeilRadiology19827063747Yes
14655515551.0138.27138.3Biochemistry and molecular cell biology of diabetic complications. M BrownleeNature200111742414Yes
147165785526.0830.79276.9Trimmomatic: a flexible trimmer for Illumina sequence data. Anthony M Bolger, Marc Lohse, Bjoern UsadelBioinformatics201424695404Yes
14854865486.00.00.0A Self-Rating Depression Scale. W W ZungArch Gen Psychiatry196514221692Yes
14954635463.0271.71271.7Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Y KandaBone Marrow Transplant201323208313Yes
150163565452.01359.04453.0MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Sudhir Kumar, Glen Stecher, Koichiro TamuraMol Biol Evol201627004904Yes
15154405440.0134.65134.7Free radicals in the physiological control of cell function. Wulf DrögePhysiol Rev200211773609No
152108665433.0251.84125.9Dendritic cells and the control of immunity. J Banchereau, R M SteinmanNature19989521319No
153108625431.0293.69146.8Sequencing end-labeled DNA with base-specific chemical cleavages. A M Maxam, W GilbertMethods Enzymol19806246368Yes
154108535426.50.00.0A series of normal stages in the development of the chick embryo. V Hamburger, H L HamiltonJ Morphol195124539719Yes
15553905390.00.00.0Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. F TietzeAnal Biochem19694388022Yes
156107755387.5272.29136.1MRBAYES: Bayesian inference of phylogenetic trees. J P Huelsenbeck, F RonquistBioinformatics200111524383Yes
15753465346.0136.51136.5New M13 vectors for cloning. J MessingMethods Enzymol19836310323Yes
158159785326.00.00.0Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. H Ohkawa, N Ohishi, K YagiAnal Biochem197936810Yes
15952705270.00.00.0Evaluation of survival data and two new rank order statistics arising in its consideration. N MantelCancer Chemother Rep19665910392Yes
16052525252.0153.02153.0Studies and perspectives of protein kinase C. Y NishizukaScience19863014651No
16152375237.0104.08104.1BLAT--the BLAST-like alignment tool. W James KentGenome Res200211932250Yes
16252315231.00.00.0Modification of seizure activity by electrical stimulation. II. Motor seizure. R J RacineElectroencephalogr Clin Neurophysiol19724110397Yes
16352305230.0128.0128.0Antimicrobial peptides of multicellular organisms. Michael ZasloffNature200211807545Yes
16452295229.0118.75118.8The biochemistry of apoptosis. M O HengartnerNature200011048727No
16552255225.0142.65142.7The Cambridge Structural Database: a quarter of a million crystal structures and rising. Frank H AllenActa Crystallogr B200212037359Yes
16652215221.00.00.0[A micro-method of immuno-electrophoresis]. J J ScheideggerInt Arch Allergy Appl Immunol195513262900Yes
167103915195.5300.68150.3MODELTEST: testing the model of DNA substitution. D Posada, K A CrandallBioinformatics19989918953Yes
168155505183.3472.1157.4A simple salting out procedure for extracting DNA from human nucleated cells. S A Miller, D D Dykes, H F PoleskyNucleic Acids Res19883344216Yes
16951805180.0189.31189.3The Strengths and Difficulties Questionnaire: a research note. R GoodmanJ Child Psychol Psychiatry19979255702Yes
17051615161.00.00.0Selective extraction of polyoma DNA from infected mouse cell cultures. B HirtJ Mol Biol19674291934Yes
17151525152.0190.28190.3Oxygen-derived free radicals in postischemic tissue injury. J M McCordN Engl J Med19852981404No
172103025151.0243.46121.7Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. W Kabsch, C SanderBiopolymers19836667333Yes
173101865093.0250.44125.2A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Stéphane Guindon, Olivier GascuelSyst Biol200314530136Yes
17450925092.0126.11126.1The NF-kappa B and I kappa B proteins: new discoveries and insights. A S BaldwinAnnu Rev Immunol19968717528No
17550835083.00.00.0The Environment And Disease: Association Or Causation? A B HillProc R Soc Med196514283879Yes
176152395079.7502.52167.5Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Daniel Dindo, Nicolas Demartines, Pierre-Alain ClavienAnn Surg200415273542Yes
177253765075.2700.23140.0The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G HigginsNucleic Acids Res19979396791Yes
17850685068.00.00.0Mutation and cancer: statistical study of retinoblastoma. A G KnudsonProc Natl Acad Sci U S A19715279523Yes
179100775038.5374.31187.2The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. R F Furchgott, J V ZawadzkiNature19806253831Yes
180100085004.0266.8133.4Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. H Schägger, G von JagowAnal Biochem19872449095Yes
18149794979.00.00.0A protein binding assay for adenosine 3':5'-cyclic monophosphate. A G GilmanProc Natl Acad Sci U S A19704318781Yes
18249774977.00.00.0Aging: a theory based on free radical and radiation chemistry. D HarmanJ Gerontol195613332224Yes
18349604960.0202.18202.2Orienting of attention. M I PosnerQ J Exp Psychol19807367577Yes
18449594959.0174.27174.3jModelTest: phylogenetic model averaging. David PosadaMol Biol Evol200818397919Yes
18549544954.0130.3130.3Inflammation and metabolic disorders. Gökhan S HotamisligilNature200617167474No
18649354935.00.00.0Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. C B LaurellAnal Biochem19665959431Yes
18749354935.0182.69182.7Analyzing Tables Of Statistical Tests. William R RiceEvolution198928568501Yes
18898654932.5227.42113.7One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. K A Datsenko, B L WannerProc Natl Acad Sci U S A200010829079Yes
18949294929.00.00.0Development of a rating scale for primary depressive illness. M HamiltonBr J Soc Clin Psychol19676080235Yes
190147864928.7539.26179.8Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. S M Hsu, L Raine, H FangerJ Histochem Cytochem19816166661Yes
19149194919.0102.26102.3Rho GTPases and the actin cytoskeleton. A HallScience19989438836No
19249084908.00.00.0Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis. M RodbellJ Biol Chem196414169133Yes
19397934896.5357.28178.6Ligand: a versatile computerized approach for characterization of ligand-binding systems. P J Munson, D RodbardAnal Biochem19806254391Yes
19448944894.0116.71116.7Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. J CastresanaMol Biol Evol200010742046Yes
195144834827.7394.2131.4Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. C Yanisch-Perron, J Vieira, J MessingGene19852985470Yes
19696544827.0275.01137.5Neuropathological stageing of Alzheimer-related changes. H Braak, E BraakActa Neuropathol19911759558No
19748234823.0257.71257.7UPARSE: highly accurate OTU sequences from microbial amplicon reads. Robert C EdgarNat Methods201323955772Yes
198144654821.7360.09120.0A comprehensive set of sequence analysis programs for the VAX. J Devereux, P Haeberli, O SmithiesNucleic Acids Res19846546423Yes
199144434814.30.00.0Determination of serum proteins by means of the biuret reaction. A G Gornall, C J Bardawill, M M DavidJ Biol Chem194918110453Yes
20048084808.0134.05134.1Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. P MatsudairaJ Biol Chem19873611052Yes
20148084808.098.8898.9Epithelial-mesenchymal transitions in tumour progression. Jean Paul ThieryNat Rev Cancer200212189386No
20295254762.50.00.0A quantitative description of membrane current and its application to conduction and excitation in nerve. A L Hodgkin, A F HuxleyJ Physiol195212991237Yes
20347624762.097.0697.1An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. M KozakNucleic Acids Res19873313277No
20447594759.0144.32144.3Developments of a water-maze procedure for studying spatial learning in the rat. R MorrisJ Neurosci Methods19846471907Yes
205142774759.0431.73143.9edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Mark D Robinson, Davis J McCarthy, Gordon K SmythBioinformatics201019910308Yes
20694374718.50.00.0A new technique for the assay of infectivity of human adenovirus 5 DNA. F L Graham, A J van der EbVirology19734705382Yes
20793634681.5346.68173.3Three approaches to qualitative content analysis. Hsiu-Fang Hsieh, Sarah E ShannonQual Health Res200516204405Yes
208139634654.3436.46145.5The PHQ-9: validity of a brief depression severity measure. K Kroenke, R L Spitzer, J B WilliamsJ Gen Intern Med200111556941Yes
20946534653.0106.37106.4ras oncogenes in human cancer: a review. J L BosCancer Res19892547513No
21093064653.0236.85118.4Improved tools for biological sequence comparison. W R Pearson, D J LipmanProc Natl Acad Sci U S A19883162770Yes
21146474647.0158.67158.7The pathogenesis of atherosclerosis--an update. R RossN Engl J Med19863511384No
21246454645.00.00.0The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification. P LaurenActa Pathol Microbiol Scand196514320675Yes
213139214640.3490.07163.4Nitric oxide: physiology, pathophysiology, and pharmacology. S Moncada, R M Palmer, E A HiggsPharmacol Rev19911852778No
21446234623.0118.06118.1Emotion circuits in the brain. J E LeDouxAnnu Rev Neurosci200010845062No
21592144607.0227.81113.9A genetic model for colorectal tumorigenesis. E R Fearon, B VogelsteinCell19902188735No
21646014601.0104.22104.2Cancer cell cycles. C J SherrScience19968939849No
21791804590.0223.98112.0Comparative protein modelling by satisfaction of spatial restraints. A Sali, T L BlundellJ Mol Biol19938254673Yes
21845894589.0132.85132.8A modified poisson regression approach to prospective studies with binary data. Guangyong ZouAm J Epidemiol200415033648Yes
21945794579.00.00.0Aggregation of blood platelets by adenosine diphosphate and its reversal. G V BornNature196213871375Yes
22045784578.00.00.0A rapid banding technique for human chromosomes. M SeabrightLancet19714107917Yes
221182634565.8575.88144.0MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir KumarMol Biol Evol200717488738Yes
22245634563.0268.95268.9Prokka: rapid prokaryotic genome annotation. Torsten SeemannBioinformatics201424642063Yes
22390684534.00.00.0Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J M McCord, I FridovichJ Biol Chem19695389100Yes
22490644532.00.00.0A new depression scale designed to be sensitive to change. S A Montgomery, M AsbergBr J Psychiatry1979444788Yes
22589814490.5207.14103.6The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. John Hardy, Dennis J SelkoeScience200212130773No
22644824482.00.00.0The clonal evolution of tumor cell populations. P C NowellScience1976959840Yes
22789604480.0202.22101.1Inflammation and cancer. Lisa M Coussens, Zena WerbNature200212490959No
228133934464.3518.63172.9The positive and negative syndrome scale (PANSS) for schizophrenia. S R Kay, A Fiszbein, L A OplerSchizophr Bull19873616518Yes
22944494449.097.5897.6ras genes. M BarbacidAnnu Rev Biochem19873304147No
23044464446.0109.26109.3A new method for predicting signal sequence cleavage sites. G von HeijneNucleic Acids Res19863714490Yes
231133244441.3302.11100.7Refinement of macromolecular structures by the maximum-likelihood method. G N Murshudov, A A Vagin, E J DodsonActa Crystallogr D Biol Crystallogr199715299926Yes
23288734436.50.00.0A simplified method of evaluating dose-effect experiments. J T Litchfield, F WilcoxonJ Pharmacol Exp Ther194918152921Yes
23388524426.0260.5130.2EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Arnaud Delorme, Scott MakeigJ Neurosci Methods200415102499Yes
23444094409.0305.12305.1SHELXT - integrated space-group and crystal-structure determination. George M SheldrickActa Crystallogr A Found Adv201525537383Yes
23544024402.095.495.4Targeting HIF-1 for cancer therapy. Gregg L SemenzaNat Rev Cancer200313130303No
23643994399.00.00.0The McGill Pain Questionnaire: major properties and scoring methods. Ronald MelzackPain19751235985Yes
23787864393.00.00.0A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. W M Bonner, R A LaskeyEur J Biochem19744850204Yes
238263574392.83437.52572.9Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin JemalCA Cancer J Clin201830207593Yes
239218124362.40.00.0An inventory for measuring depression. A T Beck, C H Ward, M Mendelson, J Mock, J ErbaughArch Gen Psychiatry196113688369Yes
24043614361.0134.05134.1A fast diffeomorphic image registration algorithm. John AshburnerNeuroimage200717761438Yes
24143494349.0100.87100.9Alzheimer's disease: genes, proteins, and therapy. D J SelkoePhysiol Rev200111274343No
24243464346.089.5989.6Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. M KozakCell19863943125Yes
24343444344.00.00.0Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. M M MesulamJ Histochem Cytochem197824068Yes
244130094336.3333.07111.0Inference of population structure using multilocus genotype data. J K Pritchard, M Stephens, P DonnellyGenetics200010835412Yes
24586594329.5199.95100.0Primer3 on the WWW for general users and for biologist programmers. S Rozen, H SkaletskyMethods Mol Biol200010547847Yes
246216374327.41166.47233.3MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir KumarMol Biol Evol201324132122Yes
24743184318.085.4885.5DNA methylation patterns and epigenetic memory. Adrian BirdGenes Dev200211782440No
24886264313.0232.58116.3BEDTools: a flexible suite of utilities for comparing genomic features. Aaron R Quinlan, Ira M HallBioinformatics201020110278Yes
24986254312.5306.06153.0AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Oleg Trott, Arthur J OlsonJ Comput Chem201019499576Yes
25043054305.00.00.0Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. W H HarrisJ Bone Joint Surg Am19695783851Yes
25142984298.00.00.0Index for rating diagnostic tests. W J YoudenCancer195015405679Yes
25285924296.00.00.0Preparation of iodine-131 labelled human growth hormone of high specific activity. W M Hunter, F C GreenwoodNature196214450081Yes
25342944294.0112.62112.6Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Y NishizukaScience19921411571No
25442934293.099.8199.8Prions. S B PrusinerProc Natl Acad Sci U S A19989811807No
25542834283.0101.43101.4MUSCLE: a multiple sequence alignment method with reduced time and space complexity. Robert C EdgarBMC Bioinformatics200415318951Yes
25642644264.00.00.0The Limited In Vitro Lifetime Of Human Diploid Cell Strains. L HayflickExp Cell Res196514315085Yes
25785044252.0288.69144.3Operating characteristics of a rank correlation test for publication bias. C B Begg, M MazumdarBiometrics19947786990Yes
25842504250.0113.39113.4The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Y NishizukaNature19883045562No
259169934248.2607.65151.9G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel BuchnerBehav Res Methods200717695343Yes
26084354217.50.00.0Parkinsonism: onset, progression and mortality. M M Hoehn, M D YahrNeurology19676067254Yes
26142114211.0112.89112.9Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. A H WyllieNature19806245367Yes
26242084208.094.4294.4Apoptosis by death factor. S NagataCell19979039262No
26342054205.0100.28100.3Cancer. p53, guardian of the genome. D P LaneNature19921614522No
26442044204.094.3594.3Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. S HenikoffGene19846235151Yes
26541994199.00.00.0Amino acid metabolism in mammalian cell cultures. H EagleScience195913675766Yes
266251714195.21028.07171.3Global cancer statistics. Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David FormanCA Cancer J Clin201121296855Yes
26741954195.0119.71119.7Mild cognitive impairment as a diagnostic entity. R C PetersenJ Intern Med200415324362No
26841914191.00.00.0A relation between non-esterified fatty acids in plasma and the metabolism of glucose. V P DoleJ Clin Invest195613286333Yes
26941864186.0167.77167.8Revisiting the behavioral model and access to medical care: does it matter? R M AndersenJ Health Soc Behav19957738325Yes
27083654182.5229.24114.6A synaptic model of memory: long-term potentiation in the hippocampus. T V Bliss, G L CollingridgeNature19938421494No
27141774177.00.00.0The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. T NashBiochem J195313105648Yes
27241694169.00.00.0Estimation of nuclear population from microtome sections. M AbercrombieAnat Rec194621015608Yes
27341194119.00.00.0The genetical evolution of social behaviour. I. W D HamiltonJ Theor Biol19645875341Yes
27482384119.0247.96124.0The rise of graphene. A K Geim, K S NovoselovNat Mater200717330084Yes
27582324116.0178.5289.3Genomic sequencing. G M Church, W GilbertProc Natl Acad Sci U S A19846326095Yes
27682144107.0239.25119.6Differential expression analysis for sequence count data. Simon Anders, Wolfgang HuberGenome Biol201020979621Yes
27741044104.00.00.0The need for a new medical model: a challenge for biomedicine. G L EngelScience1977847460Yes
27882064103.00.00.0Assessment of coma and impaired consciousness. A practical scale. G Teasdale, B JennettLancet19744136544Yes
27981984099.0195.2597.6SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. N Guex, M C PeitschElectrophoresis19979504803Yes
28040864086.087.3187.3The retinoblastoma protein and cell cycle control. R A WeinbergCell19957736585No
28140854085.0125.07125.1Glutamate neurotoxicity and diseases of the nervous system. D W ChoiNeuron19882908446No
28240844084.098.8698.9Mechanisms of angiogenesis. W RisauNature19979109485No
283244884081.31054.36175.7MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir KumarMol Biol Evol201121546353Yes
284163214080.20.00.0A new and rapid colorimetric determination of acetylcholinesterase activity. G L Ellman, K D Courtney, V Andres, R M Feather-StoneBiochem Pharmacol196113726518Yes
28540674067.087.0187.0Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. C J MarshallCell19957834738No
28640674067.00.00.0The determination of enzyme inhibitor constants. M DixonBiochem J195313093635Yes
28740524052.00.00.0Determination of protein: a modification of the Lowry method that gives a linear photometric response. E F HartreeAnal Biochem19724115981Yes
28840344034.088.6988.7Alternative activation of macrophages. Siamon GordonNat Rev Immunol200312511873No
28940124012.075.5375.5Generalized lacZ expression with the ROSA26 Cre reporter strain. P SorianoNat Genet19999916792Yes
29039893989.080.080.0The phosphoinositide 3-kinase pathway. Lewis C CantleyScience200212040186No
29139853985.00.00.0Staining of tissue sections for electron microscopy with heavy metals. M L WatsonJ Biophys Biochem Cytol195813563554Yes
29239573957.00.00.0Bone: formation by autoinduction. M R UristScience19655319761Yes
29339483948.00.00.0Disc Electrophoresis. I. Background And Theory. L OrnsteinAnn N Y Acad Sci196414240533Yes
29439463946.0126.02126.0Bacterial evolution. C R WoeseMicrobiol Rev19872439888No
29539463946.0103.35103.3Integrins: a family of cell surface receptors. R O HynesCell19873028640No
29678443922.00.00.0Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. H Aviv, P LederProc Natl Acad Sci U S A19724504350Yes
29739033903.086.7786.8Wnt/beta-catenin signaling in development and disease. Hans CleversCell200617081971No
29839013901.0129.33129.3Tissue destruction by neutrophils. S J WeissN Engl J Med19892536474No
29938953895.0121.01121.0How mitochondria produce reactive oxygen species. Michael P MurphyBiochem J200919061483No
30038933893.00.00.0The detection of disease clustering and a generalized regression approach. N MantelCancer Res19676018555Yes
30138793879.00.00.0Pharmacological implications of microsomal enzyme induction. A H ConneyPharmacol Rev19674383307Yes
30238703870.0120.67120.7Nitric oxide as a secretory product of mammalian cells. C NathanFASEB J19921381691No
30338593859.0107.43107.4What is the evidence that tumors are angiogenesis dependent? J FolkmanJ Natl Cancer Inst19901688381No
30476443822.00.00.0Functional Evaluation: The Barthel Index. F I Mahoney, D W BarthelMd State Med J196514258950Yes
30538153815.087.4187.4PAML: a program package for phylogenetic analysis by maximum likelihood. Z YangComput Appl Biosci19979367129Yes
306114153805.0836.85278.9Cancer statistics, 2016. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201626742998Yes
30738033803.0159.17159.2An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. Peter C AustinMultivariate Behav Res201121818162Yes
30876003800.00.00.0Assessment of older people: self-maintaining and instrumental activities of daily living. M P Lawton, E M BrodyGerontologist19695349366Yes
309113973799.00.00.0Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. W H Habig, M J Pabst, W B JakobyJ Biol Chem19744436300Yes
31075813790.50.00.0Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. D E Paglia, W N ValentineJ Lab Clin Med19676066618Yes
31137743774.080.4580.5A catalogue of splice junction sequences. S M MountNucleic Acids Res19827063411Yes
31237573757.0104.76104.8Revisions in the International System for Staging Lung Cancer. C F MountainChest19979187198Yes
31337553755.00.00.0Estimation of the molecular weights of proteins by Sephadex gel-filtration. P AndrewsBiochem J19644158310Yes
31437473747.00.00.0New methods for calculating metabolic rate with special reference to protein metabolism. J B De B WeirJ Physiol194915394301Yes
31537343734.084.6984.7Atherosclerosis. A J LusisNature200011001066No
31637333733.00.00.0Preparation of isolated rat liver cells. P O SeglenMethods Cell Biol1976177845No
31774493724.5141.1670.6A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. R S Sikorski, P HieterGenetics19892659436Yes
31837243724.0107.65107.7Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. J H MorrisseyAnal Biochem19816172996Yes
31974163708.0183.9292.0Collective dynamics of 'small-world' networks. D J Watts, S H StrogatzNature19989623998Yes
320111213707.0215.271.7Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. J D Dignam, R M Lebovitz, R G RoederNucleic Acids Res19836828386Yes
32137043704.0139.18139.2EuroQol: the current state of play. R BrooksHealth Policy199610158943No
32237033703.080.6680.7The green fluorescent protein. R Y TsienAnnu Rev Biochem19989759496No
32337023702.00.00.0A membrane-filter technique for the detection of complementary DNA. D T DenhardtBiochem Biophys Res Commun19665963888Yes
32473883694.0219.28109.6Estimating F-Statistics For The Analysis Of Population Structure. B S Weir, C Clark CockerhamEvolution198428563791Yes
325110163672.00.00.0Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. J F Kerr, A H Wyllie, A R CurrieBr J Cancer19724561027No
326220153669.2741.1123.5Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C TurnerDiabetologia19853899825Yes
32736633663.0130.1130.1Whatever happened to qualitative description? M SandelowskiRes Nurs Health200010940958No
32836473647.00.00.0A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. E PfeifferJ Am Geriatr Soc19751159263Yes
32936443644.090.7590.8Multiple sequence alignment with hierarchical clustering. F CorpetNucleic Acids Res19882849754Yes
33036413641.0124.13124.1Updating P300: an integrative theory of P3a and P3b. John PolichClin Neurophysiol200717573239No
33172783639.0177.5188.8MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Jürgen Cox, Matthias MannNat Biotechnol200819029910Yes
332109093636.3492.41164.1Development and validation of brief measures of positive and negative affect: the PANAS scales. D Watson, L A Clark, A TellegenJ Pers Soc Psychol19883397865Yes
33336343634.088.1488.1Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. A T BrüngerNature199218481394Yes
33436333633.089.2689.3Caspases: the executioners of apoptosis. G M CohenBiochem J19979337844No
33572633631.5182.4291.2Mitochondria and apoptosis. D R Green, J C ReedScience19989721092No
33636233623.098.6398.6Staphylococcus aureus infections. F D LowyN Engl J Med19989709046No
33736163616.077.4277.4TGF-beta signal transduction. J MassaguéAnnu Rev Biochem19989759503No
33872313615.50.00.0The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. R C Graham, M J KarnovskyJ Histochem Cytochem19665962951Yes
339144383609.5401.62100.4Global cancer statistics, 2002. D Max Parkin, Freddie Bray, J Ferlay, Paola PisaniCA Cancer J Clin200515761078Yes
34071963598.0208.75104.4Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. Florian Weigend, Reinhart AhlrichsPhys Chem Chem Phys200516240044Yes
34135943594.083.7683.8Tandem repeats finder: a program to analyze DNA sequences. G BensonNucleic Acids Res19999862982Yes
34235933593.0109.75109.8Inositol trisphosphate and diacylglycerol as second messengers. M J BerridgeBiochem J19846146314No
34335903590.00.00.0Evolution in Mendelian Populations. S WrightGenetics193117246615Yes
34435743574.00.00.0Principles that govern the folding of protein chains. C B AnfinsenScience19734124164Yes
34535653565.091.1691.2Why most published research findings are false. John P A IoannidisPLoS Med200516060722Yes
34635433543.065.7465.7Somatic generation of antibody diversity. S TonegawaNature19836300689No
34770693534.5286.8143.4Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Kristopher J Preacher, Andrew F HayesBehav Res Methods200818697684Yes
34870293514.5133.466.7Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. A H Brand, N PerrimonDevelopment19938223268Yes
34970233511.5251.43125.7DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. P Librado, J RozasBioinformatics200919346325Yes
35035083508.073.5873.6Hypoxia--a key regulatory factor in tumour growth. Adrian L HarrisNat Rev Cancer200211902584No
351140033500.8417.07104.3Features and development of Coot. P Emsley, B Lohkamp, W G Scott, K CowtanActa Crystallogr D Biol Crystallogr201020383002Yes
35234993499.075.4175.4Protein secondary structure prediction based on position-specific scoring matrices. D T JonesJ Mol Biol199910493868Yes
35334953495.098.6998.7Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. R B D'AgostinoStat Med19989802183Yes
35434933493.070.3470.3Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. G R MartinProc Natl Acad Sci U S A19816950406Yes
355104763492.0907.33302.4Cancer Statistics, 2017. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201728055103Yes
35634903490.098.5298.5Biological roles of oligosaccharides: all of the theories are correct. A VarkiGlycobiology19938490246No
35734893489.082.0882.1Novel proteinaceous infectious particles cause scrapie. S B PrusinerScience19826801762Yes
35869723486.0226.14113.1RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. Bo Li, Colin N DeweyBMC Bioinformatics201121816040Yes
35934823482.00.00.0Statistical estimations in enzyme kinetics. G N WilkinsonBiochem J196113785321Yes
36034783478.00.00.0Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. J CohenPsychol Bull196819673146Yes
36134773477.0102.13102.1Sequencing technologies - the next generation. Michael L MetzkerNat Rev Genet201019997069No
36234723472.084.5884.6Marrow stromal cells as stem cells for nonhematopoietic tissues. D J ProckopScience19979082988No
36369333466.50.00.0A new method for sequencing DNA. A M Maxam, W GilbertProc Natl Acad Sci U S A1977265521Yes
364173103462.0504.32100.9Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. O P Hamill, A Marty, E Neher, B Sakmann, F J SigworthPflugers Arch19816270629Yes
36534613461.00.00.0Spectroscopic determination of tryptophan and tyrosine in proteins. H EdelhochBiochemistry19676049437Yes
36634563456.0118.16118.2Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Russell A BarkleyPsychol Bull19979000892No
36734533453.0133.08133.1Measuring the accuracy of diagnostic systems. J A SwetsScience19883287615No
36834523452.080.4380.4Protein production by auto-induction in high density shaking cultures. F William StudierProtein Expr Purif200515915565Yes
36968803440.0164.082.0"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. A P Feinberg, B VogelsteinAnal Biochem19846329026Yes
37068703435.0156.5278.3Functional rafts in cell membranes. K Simons, E IkonenNature19979177342No
37168543427.00.00.0Radiological assessment of osteo-arthrosis. J H Kellgren, J S LawrenceAnn Rheum Dis195713498604Yes
37234193419.00.00.0The Scree Test For The Number Of Factors. R B CattellMultivariate Behav Res196626828106Yes
37334173417.078.3778.4Instability and decay of the primary structure of DNA. T LindahlNature19938469282No
374102493416.3395.76131.9A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. J Ware, M Kosinski, S D KellerMed Care19968628042Yes
37534143414.081.5481.5Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Rakesh K JainScience200515637262No
37668173408.5177.1388.6tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. T M Lowe, S R EddyNucleic Acids Res19979023104Yes
37734043404.00.00.0Generalized expectancies for internal versus external control of reinforcement. J B RotterPsychol Monogr19665340840No
37867963398.0253.31126.7Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. U H Graneheim, B LundmanNurse Educ Today200414769454No
37933853385.070.9871.0Mammalian neural stem cells. F H GageScience200010688783No
38033773377.00.00.0Basic principles of ROC analysis. C E MetzSemin Nucl Med1978112681Yes
381101283376.00.00.0The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity. F C Greenwood, W M Hunter, J S GloverBiochem J196314097352Yes
38233703370.00.00.0The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. J F WoessnerArch Biochem Biophys196113786180Yes
38367203360.0207.6103.8BEAST: Bayesian evolutionary analysis by sampling trees. Alexei J Drummond, Andrew RambautBMC Evol Biol200717996036Yes
38433373337.0102.96103.0Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. L R SquirePsychol Rev19921594723No
38533343334.083.5883.6The heat-shock response. S LindquistAnnu Rev Biochem19862427013No
38666603330.0172.6686.3TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. T R Mosmann, R L CoffmanAnnu Rev Immunol19892523712No
38733263326.068.8268.8Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. M KozakNucleic Acids Res19846694911Yes
38866493324.5286.53143.3The timed "Up & Go": a test of basic functional mobility for frail elderly persons. D Podsiadlo, S RichardsonJ Am Geriatr Soc19911991946Yes
38933163316.078.9378.9The dendritic cell system and its role in immunogenicity. R M SteinmanAnnu Rev Immunol19911910679No
39033123312.00.00.0Equilibrium Ultracentrifugation Of Dilute Solutions. D A YphantisBiochemistry196414155091Yes
39199363312.0469.55156.5Cancer statistics, 2013. Rebecca Siegel, Deepa Naishadham, Ahmedin JemalCA Cancer J Clin201323335087Yes
39233103310.068.6468.6The scanning model for translation: an update. M KozakJ Cell Biol19892645293No
39333103310.077.3277.3Scaling and assessment of data quality. Philip EvansActa Crystallogr D Biol Crystallogr200616369096No
39433043304.088.2888.3Microglia: a sensor for pathological events in the CNS. G W KreutzbergTrends Neurosci19968843599No
39532993299.084.4284.4Gene regulation by steroid hormones. M BeatoCell19892644044No
39632993299.00.00.0Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. J D RowleyNature19734126434Yes
39765883294.0176.7288.4Control of goal-directed and stimulus-driven attention in the brain. Maurizio Corbetta, Gordon L ShulmanNat Rev Neurosci200211994752No
39832913291.099.7299.7What's wrong with Bonferroni adjustments. T V PernegerBMJ19989553006No
39932893289.065.2165.2Signal transduction by the JNK group of MAP kinases. R J DavisCell200011057897No
40032853285.092.1392.1Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. R W MahleyScience19883283935No
40198393279.71154.48384.8Cancer statistics, 2018. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201829313949Yes
40232733273.00.00.0Some factors in the interpretation of protein denaturation. W KauzmannAdv Protein Chem195914404936Yes
40332693269.099.8299.8Protective and damaging effects of stress mediators. B S McEwenN Engl J Med19989428819No
40465363268.0190.4395.2Ab initio molecular dynamics for liquid metals. Kresse, HafnerPhys Rev B Condens Matter199310004490Yes
40598003266.7423.41141.1Cancer statistics, 2012. Rebecca Siegel, Deepa Naishadham, Ahmedin JemalCA Cancer J Clin201222237781Yes
406130383259.5305.7776.4Improved methods for building protein models in electron density maps and the location of errors in these models. T A Jones, J Y Zou, S W Cowan, M KjeldgaardActa Crystallogr A19912025413Yes
40732563256.0113.76113.8genepop'007: a complete re-implementation of the genepop software for Windows and Linux. François RoussetMol Ecol Resour200821585727Yes
40832493249.084.6284.6Biologic basis for interleukin-1 in disease. C A DinarelloBlood19968630372No
40964903245.0124.0562.0Translating the histone code. T Jenuwein, C D AllisScience200111498575No
41032423242.0128.78128.8A concordance correlation coefficient to evaluate reproducibility. L I LinBiometrics19892720055Yes
41132403240.0109.27109.3Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. Ilan H MeyerPsychol Bull200312956539No
41232303230.0115.61115.6How do you feel--now? The anterior insula and human awareness. A D Bud CraigNat Rev Neurosci200919096369No
41332293229.00.00.0Estimation of average heterozygosity and genetic distance from a small number of individuals. M NeiGenetics197817248844Yes
41464463223.00.00.0Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. D H Hubel, T N WieselJ Physiol196214449617Yes
41532213221.00.00.0Observational study of behavior: sampling methods. J AltmannBehaviour19744597405No
41632193219.0128.86128.9Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. O W GriffithAnal Biochem19807416462Yes
41764363218.0246.65123.3The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. I F Benzie, J J StrainAnal Biochem19968660627Yes
41832113211.087.9788.0The adolescent brain and age-related behavioral manifestations. L P SpearNeurosci Biobehav Rev200010817843No
41932103210.092.9893.0Inositol trisphosphate and diacylglycerol: two interacting second messengers. M J BerridgeAnnu Rev Biochem19873304132No
42031823182.077.0777.1Nonalcoholic fatty liver disease. Paul AnguloN Engl J Med200211961152No
42131783178.00.00.0Diffusion-in-gel methods for immunological analysis. O OuchterlonyProg Allergy195813578996Yes
42231763176.076.7876.8Glutamate uptake. N C DanboltProg Neurobiol200111369436No
42395163172.0582.05194.0Cancer statistics, 2015. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201525559415Yes
42431683168.087.8587.8Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Kim A BrogdenNat Rev Microbiol200515703760No
42531623162.096.4696.5Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. VanderbiltPhys Rev B Condens Matter19909993096Yes
42631603160.079.4479.4The transforming growth factor-beta family. J MassaguéAnnu Rev Cell Biol19902177343No
42731583158.00.00.0Notes on sugar determination. M SmogyiJ Biol Chem195214938350Yes
42831513151.083.7883.8Oxidative stress, antioxidants and stress tolerance. Ron MittlerTrends Plant Sci200212234732No
42931503150.00.00.0Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. S W KesslerJ Immunol19751102604Yes
43063003150.0165.7182.9An integrative theory of prefrontal cortex function. E K Miller, J D CohenAnnu Rev Neurosci200111283309No
43131423142.068.168.1Profile hidden Markov models. S R EddyBioinformatics19989918945No
432125553138.8539.33134.8Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanAnn Intern Med200919622511No
43331343134.085.1785.2ABC transporters: from microorganisms to man. C F HigginsAnnu Rev Cell Biol19921282354No
43431293129.073.3973.4Tolerance, danger, and the extended family. P MatzingerAnnu Rev Immunol19948011301No
43531273127.00.00.0The magical number seven plus or minus two: some limits on our capacity for processing information. G A MillerPsychol Rev195613310704Yes
43693643121.3312.59104.2Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. E R DeLong, D M DeLong, D L Clarke-PearsonBiometrics19883203132Yes
43731013101.0101.02101.0Graphene: status and prospects. A K GeimScience200919541989Yes
43830943094.0104.03104.0Modeling valuations for EuroQol health states. P DolanMed Care19979366889Yes
43930943094.083.9383.9I-TASSER server for protein 3D structure prediction. Yang ZhangBMC Bioinformatics200818215316Yes
440123683092.0326.0381.5Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Ben Langmead, Cole Trapnell, Mihai Pop, Steven L SalzbergGenome Biol200919261174Yes
441185503091.71171.98195.3Global cancer statistics, 2012. Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin JemalCA Cancer J Clin201525651787Yes
44261723086.00.00.0Microsomal lipid peroxidation. J A Buege, S D AustMethods Enzymol1978672633Yes
44392303076.7385.88128.6A global measure of perceived stress. S Cohen, T Kamarck, R MermelsteinJ Health Soc Behav19836668417Yes
44430713071.064.0864.1CpG-rich islands and the function of DNA methylation. A P BirdNature19862423876No
44530673067.085.2685.3The origins and the future of microfluidics. George M WhitesidesNature200616871203No
44630573057.062.3462.3STATs and gene regulation. J E DarnellScience19979287210No
44730533053.058.7158.7Cell signaling by receptor tyrosine kinases. J SchlessingerCell200011057895No
44861053052.5186.793.3Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Daniel R Zerbino, Ewan BirneyGenome Res200818349386Yes
44961023051.00.00.0Human malaria parasites in continuous culture. W Trager, J B JensenScience1976781840Yes
45030483048.068.8668.9Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. H F DvorakN Engl J Med19863537791No
45130443044.072.7272.7WHAT IF: a molecular modeling and drug design program. G VriendJ Mol Graph19902268628Yes
45260793039.52125.561062.8Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. Zunyou Wu, Jennifer M McGooganJAMA202032091533Yes
45360703035.0120.8360.4The ubiquitin system. A Hershko, A CiechanoverAnnu Rev Biochem19989759494No
45430343034.067.867.8Activators and target genes of Rel/NF-kappaB transcription factors. H L PahlOncogene199910602461No
45590843028.0312.41104.1Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. R M Palmer, A G Ferrige, S MoncadaNature19873495737Yes
45630253025.00.00.0Towards a network theory of the immune system. N K JerneAnn Immunol (Paris)19744142565No
45730183018.072.9172.9Folding DNA to create nanoscale shapes and patterns. Paul W K RothemundNature200616541064Yes
45860173008.5135.7667.9Angiogenesis in cancer and other diseases. P Carmeliet, R K JainNature200011001068No
45960123006.0127.5963.8Statistical significance for genomewide studies. John D Storey, Robert TibshiraniProc Natl Acad Sci U S A200312883005Yes
46029982998.00.00.0A study of fixation for electron microscopy. G E PaladeJ Exp Med195214927794Yes
46129912991.070.5670.6Cadherin cell adhesion receptors as a morphogenetic regulator. M TakeichiScience19912006419No
46289642988.01625.38541.8Cancer statistics, 2019. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201930620402Yes
46329782978.073.9273.9Neural networks and physical systems with emergent collective computational abilities. J J HopfieldProc Natl Acad Sci U S A19826953413Yes
46429762976.074.0674.1Wound healing--aiming for perfect skin regeneration. P MartinScience19979082989No
46529752975.00.00.0A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide. S HakomoriJ Biochem196414135466Yes
46629742974.074.5474.5Photoelectrochemical cells. M GrätzelNature200111713540Yes
46759422971.0169.4184.7The basics of epithelial-mesenchymal transition. Raghu Kalluri, Robert A WeinbergJ Clin Invest200919487818No
46829662966.00.00.0The gel-filtration behaviour of proteins related to their molecular weights over a wide range. P AndrewsBiochem J19655862401Yes
46929612961.097.1497.1Emerging adulthood. A theory of development from the late teens through the twenties. J J ArnettAm Psychol200010842426Yes
47029552955.073.1973.2Phase separation of integral membrane proteins in Triton X-114 solution. C BordierJ Biol Chem19816257680Yes
47129492949.082.4482.4Hay fever, hygiene, and household size. D P StrachanBMJ19892513902Yes
47258962948.0232.27116.1Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Laurent Excoffier, Heidi E L LischerMol Ecol Resour201021565059Yes
47358952947.5124.7162.4Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. D B Smith, K S JohnsonGene19883047011Yes
47458922946.0151.2575.6WGCNA: an R package for weighted correlation network analysis. Peter Langfelder, Steve HorvathBMC Bioinformatics200819114008Yes
47529372937.085.8185.8EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. W KlimeschBrain Res Brain Res Rev199910209231No
47629362936.075.8775.9The basis of anisotropic water diffusion in the nervous system - a technical review. Christian BeaulieuNMR Biomed200212489094No
47729252925.00.00.0Gene action in the X-chromosome of the mouse (Mus musculus L.). M F LyonNature196113764598Yes
47829242924.00.00.0Transformed up-down methods in psychoacoustics. H LevittJ Acoust Soc Am19715541744Yes
47929222922.078.978.9The pathobiology of diabetic complications: a unifying mechanism. Michael BrownleeDiabetes200515919781No
48029102910.00.00.0Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. W C SchneiderJ Biol Chem194521005736Yes
48129092909.091.1191.1Matrix metalloproteinases and their inhibitors in connective tissue remodeling. J F WoessnerFASEB J19911850705No
48229082908.064.6264.6Mechanisms of angiogenesis and arteriogenesis. P CarmelietNat Med200010742145No
48358152907.5144.2572.1Inference of macromolecular assemblies from crystalline state. Evgeny Krissinel, Kim HenrickJ Mol Biol200717681537Yes
48486982899.3243.2481.1Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Y Gavrieli, Y Sherman, S A Ben-SassonJ Cell Biol19921400587Yes
48528962896.00.00.0Catheter replacement of the needle in percutaneous arteriography; a new technique. S I SeldingerActa radiol195313057644Yes
486202032886.1476.8268.1UCSF Chimera--a visualization system for exploratory research and analysis. Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E FerrinJ Comput Chem200415264254Yes
48786582886.0180.3860.1Significance analysis of microarrays applied to the ionizing radiation response. V G Tusher, R Tibshirani, G ChuProc Natl Acad Sci U S A200111309499Yes
48828812881.069.7669.8Chemokines--chemotactic cytokines that mediate inflammation. A D LusterN Engl J Med19989459648No
48928712871.051.3551.4One-step gene disruption in yeast. R J RothsteinMethods Enzymol19836310324Yes
49028692869.097.5697.6Functions of DNA methylation: islands, start sites, gene bodies and beyond. Peter A JonesNat Rev Genet201222641018No
49128662866.060.6960.7The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Isaiah J FidlerNat Rev Cancer200312778135No
49285962865.30.00.0The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. R J Havel, H A Eder, J H BragdonJ Clin Invest195513252080Yes
49328652865.064.6164.6Angiogenesis in health and disease. Peter CarmelietNat Med200312778163No
49457282864.0229.28114.6Management of hepatocellular carcinoma: an update. Jordi Bruix, Morris ShermanHepatology201121374666No
49557262863.0163.081.5Inositol trisphosphate, a novel second messenger in cellular signal transduction. M J Berridge, R F IrvineNature19846095092No
49628592859.00.00.0Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. B E MurphyJ Clin Endocrinol Metab19674291524Yes
49728562856.074.9274.9How do you feel? Interoception: the sense of the physiological condition of the body. A D CraigNat Rev Neurosci200212154366No
49828542854.00.00.0Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. L SvennerholmBiochim Biophys Acta195713436486Yes
49928502850.0117.68117.7Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. T E MoffittPsychol Rev19938255953No
50028472847.063.4363.4Protein folding and misfolding. Christopher M DobsonNature200314685248No
50185372845.70.00.0Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. G Fairbanks, T L Steck, D F WallachBiochemistry19714326772Yes
50228432843.089.7589.8Development of a classification system for periodontal diseases and conditions. G C ArmitageAnn Periodontol199910863370No
50356812840.50.00.0Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Glowinski, L L IversenJ Neurochem19665950056Yes
50428392839.078.7878.8Mesenchymal stem cells. A I CaplanJ Orthop Res19911870029Yes
50556782839.0128.9564.5Toll-like receptor signalling. Shizuo Akira, Kiyoshi TakedaNat Rev Immunol200415229469No
50656722836.0137.2168.6Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. C Tuerk, L GoldScience19902200121Yes
50785072835.7190.1763.4Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Benjamin P Lewis, Christopher B Burge, David P BartelCell200515652477Yes
50828272827.092.9693.0An empirical correction for absorption anisotropy. R H BlessingActa Crystallogr A19957702794Yes
50928232823.061.5861.6Alzheimer's disease is a synaptic failure. Dennis J SelkoeScience200212399581No
51028212821.0110.66110.7Half a century of research on the Stroop effect: an integrative review. C M MacLeodPsychol Bull19912034749No
51128202820.072.4272.4Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Ting-Chao ChouPharmacol Rev200616968952No
51256382819.0135.767.8MicroRNA signatures in human cancers. George A Calin, Carlo M CroceNat Rev Cancer200617060945No
51328152815.00.00.0A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples. E A GehanBiometrika196514341275Yes
51456282814.00.00.0Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. C Beauchamp, I FridovichAnal Biochem19714943714Yes
51556282814.00.00.0A method for determining the sedimentation behavior of enzymes: application to protein mixtures. R G Martin, B N AmesJ Biol Chem196113767412Yes
51656242812.0146.1173.1The plant immune system. Jonathan D G Jones, Jeffery L DanglNature200617108957No
51728112811.00.00.0A study of the adrenotropic receptors. R P AhlquistAm J Physiol194818882199Yes
51828092809.054.9755.0RNA interference. Gregory J HannonNature200212110901No
51956032801.5111.655.8High-efficiency transformation of mammalian cells by plasmid DNA. C Chen, H OkayamaMol Cell Biol19873670292Yes
52028012801.0162.73162.7Executive functions. Adele DiamondAnnu Rev Psychol201323020641No
521112012800.2453.0113.2APACHE II: a severity of disease classification system. W A Knaus, E A Draper, D P Wagner, J E ZimmermanCrit Care Med19853928249Yes
52227992799.083.1483.1Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. Thomas WeltonChem Rev199911849019Yes
52327972797.059.4959.5Principles of CDK regulation. D O MorganNature19957877684No
52455842792.0103.2751.6The language of covalent histone modifications. B D Strahl, C D AllisNature200010638745Yes
525111432785.80.00.0Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. P W Rigby, M Dieckmann, C Rhodes, P BergJ Mol Biol1977881736Yes
52627832783.094.2594.2Role of oxidative stress in development of complications in diabetes. J W BaynesDiabetes19912010041No
52755662783.0152.7776.4The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. J Vieira, J MessingGene19826295879Yes
52883402780.0226.7675.6Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Da Wei Huang, Brad T Sherman, Richard A LempickiNucleic Acids Res200919033363Yes
52955592779.50.00.0Pain mechanisms: a new theory. R Melzack, P D WallScience19655320816No
53083302776.7180.4360.1Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. C M Gorman, L F Moffat, B H HowardMol Cell Biol19826960240Yes
531110972774.2281.8670.5Haploview: analysis and visualization of LD and haplotype maps. J C Barrett, B Fry, J Maller, M J DalyBioinformatics200515297300Yes
53255452772.50.00.0Assessment of outcome after severe brain damage. B Jennett, M BondLancet197546957Yes
53327692769.00.00.0Efficient trace-labelling of proteins with iodine. A S McFARLANENature195813566175Yes
53455342767.0162.3881.2Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. S Duval, R TweedieBiometrics200010877304Yes
53555322766.00.00.0A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. S Reitman, S FrankelAm J Clin Pathol195713458125Yes
53627652765.092.2692.3Health promotion by social cognitive means. Albert BanduraHealth Educ Behav200415090118Yes
53727622762.068.5468.5Obesity as a medical problem. P G KopelmanNature200010766250No
53855102755.00.00.0The fluid mosaic model of the structure of cell membranes. S J Singer, G L NicolsonScience19724333397Yes
53927542754.00.00.0Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. P CuatrecasasJ Biol Chem19705432796Yes
54055052752.5145.7872.9Voxel-based morphometry--the methods. J Ashburner, K J FristonNeuroimage200010860804No
54127322732.083.8783.9Implications of normal brain development for the pathogenesis of schizophrenia. D R WeinbergerArch Gen Psychiatry19873606332Yes
54254582729.0162.0281.0Projections of global mortality and burden of disease from 2002 to 2030. Colin D Mathers, Dejan LoncarPLoS Med200617132052Yes
54354482724.0243.61121.8Revised methods for the Salmonella mutagenicity test. D M Maron, B N AmesMutat Res19836341825Yes
54427192719.096.3196.3The processing-speed theory of adult age differences in cognition. T A SalthousePsychol Rev19968759042No
54527172717.00.00.0Measurement of pain. E C HuskissonLancet19744139420Yes
54627162716.0126.26126.3The quality of care. How can it be assessed? A DonabedianJAMA19883045356No
54754262713.0127.9364.0Caspases: enemies within. N A Thornberry, Y LazebnikScience19989721091No
54827092709.066.466.4Cell death during development of the nervous system. R W OppenheimAnnu Rev Neurosci19912031577No
54927062706.091.7191.7Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Sarah E BarlowPediatrics200718055651Yes
55054082704.00.00.0The serial cultivation of human diploid cell strains. L Hayflick, P S MoorheadExp Cell Res196113905658Yes
55154052702.5131.4665.7Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. T C Chou, P TalalayAdv Enzyme Regul19846382953Yes
55227012701.060.4760.5Cardiac excitation-contraction coupling. Donald M BersNature200211805843No
55327002700.092.7892.8Hepatocellular carcinoma. Hashem B El-SeragN Engl J Med201121992124No
55480832694.3214.0171.3MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Sudhir Kumar, Koichiro Tamura, Masatoshi NeiBrief Bioinform200415260895Yes
55526932693.060.9861.0Inflammatory bowel disease. Daniel K PodolskyN Engl J Med200212167685No
55626932693.082.5682.6Drug combination studies and their synergy quantification using the Chou-Talalay method. Ting-Chao ChouCancer Res201020068163Yes
55726882688.071.371.3Optimal two-stage designs for phase II clinical trials. R SimonControl Clin Trials19892702835Yes
55826872687.072.8372.8Recent advances with liposomes as pharmaceutical carriers. Vladimir P TorchilinNat Rev Drug Discov200515688077No
559107482687.0377.9494.5Cancer statistics, 2010. Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth WardCA Cancer J Clin201020610543Yes
56026822682.056.356.3Toll-like receptors and innate immunity. R MedzhitovNat Rev Immunol200111905821No
56126782678.065.1565.2Mitochondrial formation of reactive oxygen species. Julio F TurrensJ Physiol200314561818No
56253552677.50.00.0A modified uronic acid carbazole reaction. T Bitter, H M MuirAnal Biochem196213971270Yes
56326762676.064.2964.3Structure and function of telomeres. E H BlackburnNature19911708110No
56426702670.063.9463.9Molecular chaperones in cellular protein folding. F U HartlNature19968637592No
56553372668.5127.3163.7Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. F W Studier, B A MoffattJ Mol Biol19863537305Yes
56680022667.3390.4130.1HTSeq--a Python framework to work with high-throughput sequencing data. Simon Anders, Paul Theodor Pyl, Wolfgang HuberBioinformatics201525260700Yes
56726672667.076.7876.8Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. Y X FuGenetics19979335623Yes
56826622662.052.2552.2Genome maintenance mechanisms for preventing cancer. J H HoeijmakersNature200111357144No
56926622662.083.5883.6Non-coding RNAs in human disease. Manel EstellerNat Rev Genet201122094949No
57053232661.5174.2387.1Tissue engineering. R Langer, J P VacantiScience19938493529No
57153012650.5126.4463.2Oncomirs - microRNAs with a role in cancer. Aurora Esquela-Kerscher, Frank J SlackNat Rev Cancer200616557279No
57226472647.072.0872.1Origin and physiological roles of inflammation. Ruslan MedzhitovNature200818650913No
57326412641.00.00.0Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. P MitchellNature196113771349Yes
57426392639.0123.96124.0The short-form McGill Pain Questionnaire. Ronald MelzackPain19873670870Yes
57552752637.5131.4565.7In vitro selection of RNA molecules that bind specific ligands. A D Ellington, J W SzostakNature19901697402Yes
57626372637.051.9952.0Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. P SchuckBiophys J200010692345Yes
57752552627.5132.3166.2Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. D Hanahan, J FolkmanCell19968756718No
57826262626.085.9686.0Psychometric properties of the strengths and difficulties questionnaire. R GoodmanJ Am Acad Child Adolesc Psychiatry200111699809Yes
57952492624.5164.2982.1Glutathione. A Meister, M E AndersonAnnu Rev Biochem19836137189No
58052452622.50.00.0Some quantitative uses of drug antagonists. O Arunlakshana, H O SchildBr J Pharmacol Chemother195913651579Yes
58126222622.081.6381.6Primate models of movement disorders of basal ganglia origin. M R DeLongTrends Neurosci19901695404No
58226222622.049.3249.3Wnt signaling and cancer. P PolakisGenes Dev200010921899No
58326212621.00.00.0A gene complex controlling segmentation in Drosophila. E B LewisNature1978103000Yes
58478582619.3204.6468.2TopHat: discovering splice junctions with RNA-Seq. Cole Trapnell, Lior Pachter, Steven L SalzbergBioinformatics200919289445Yes
58526182618.00.00.0Stereotaxic mapping of the monoamine pathways in the rat brain. U UngerstedtActa Physiol Scand Suppl19714109331Yes
58626172617.00.00.0The genetical structure of populations. S WrightAnn Eugen195124540312Yes
58726142614.00.00.0A simple technique for demonstrating centromeric heterochromatin. A T SumnerExp Cell Res19724117921Yes
58852282614.0123.0761.5Oxidants, oxidative stress and the biology of ageing. T Finkel, N J HolbrookNature200011089981No
58952072603.5179.8389.9Measuring agreement in method comparison studies. J M Bland, D G AltmanStat Methods Med Res199910501650No
590104082602.0230.1957.5Cluster analysis and display of genome-wide expression patterns. M B Eisen, P T Spellman, P O Brown, D BotsteinProc Natl Acad Sci U S A19989843981Yes
59151932596.5183.0591.5A simple, rapid, and sensitive DNA assay procedure. C Labarca, K PaigenAnal Biochem19806158890Yes
59251912595.5146.6873.3Fast and accurate long-read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics201020080505Yes
59325952595.00.00.0The membrane actions of anesthetics and tranquilizers. P SeemanPharmacol Rev19724565956No
59425942594.081.5281.5Estimation of metabolite concentrations from localized in vivo proton NMR spectra. S W ProvencherMagn Reson Med19938139448Yes
59525862586.082.5882.6Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. B SamuelssonScience19836301011Yes
59625812581.061.8261.8TGFbeta in Cancer. Joan MassaguéCell200818662538No
597103212580.2433.29108.3Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanBMJ200919622551No
59825772577.060.0960.1Nuclear factor-kappaB in cancer development and progression. Michael KarinNature200616724054No
59951482574.0116.9458.5Signal transduction by receptors with tyrosine kinase activity. A Ullrich, J SchlessingerCell19902158859No
60051372568.5186.0393.0A method of comparing the areas under receiver operating characteristic curves derived from the same cases. J A Hanley, B J McNeilRadiology19836878708Yes
60125672567.084.8984.9No adjustments are needed for multiple comparisons. K J RothmanEpidemiology19902081237Yes
60225652565.00.00.0The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. R R PorterBiochem J195914434282Yes
60325642564.00.00.0The biology of oxygen radicals. I FridovichScience1978210504Yes
60425642564.00.00.0Analysis of gene diversity in subdivided populations. M NeiProc Natl Acad Sci U S A19734519626Yes
60525632563.059.5759.6Cell adhesion: the molecular basis of tissue architecture and morphogenesis. B M GumbinerCell19968608588No
60651252562.5105.752.9Establishment in culture of pluripotential cells from mouse embryos. M J Evans, M H KaufmanNature19817242681Yes
60776832561.0260.0986.7Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. R A Deyo, D C Cherkin, M A CiolJ Clin Epidemiol19921607900Yes
60825612561.045.6745.7Mechanisms underlying ubiquitination. C M PickartAnnu Rev Biochem200111395416No
60925602560.064.3464.3The nerve growth factor 35 years later. R Levi-MontalciniScience19873306916No
61051202560.0189.7594.9Longitudinal data analysis for discrete and continuous outcomes. S L Zeger, K Y LiangBiometrics19863719049Yes
61125582558.060.1360.1Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. S A BustinJ Mol Endocrinol200011013345No
612127782555.6516.72103.3The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. D J Buysse, C F Reynolds, T H Monk, S R Berman, D J KupferPsychiatry Res19892748771Yes
61325542554.054.154.1Papillomaviruses and cancer: from basic studies to clinical application. Harald zur HausenNat Rev Cancer200212044010No
61425542554.00.00.0Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. O SmithiesBiochem J195513276348Yes
61551022551.00.00.0Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. L A Greene, A S TischlerProc Natl Acad Sci U S A19761065897Yes
61676402546.7214.371.4Understanding the Warburg effect: the metabolic requirements of cell proliferation. Matthew G Vander Heiden, Lewis C Cantley, Craig B ThompsonScience200919460998No
617152702545.0621.79103.6Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G CondeJ Biomed Inform200918929686Yes
61825442544.0119.58119.6Detecting alcoholism. The CAGE questionnaire. J A EwingJAMA19846471323Yes
61925442544.089.089.0Essential oils: their antibacterial properties and potential applications in foods--a review. Sara BurtInt J Food Microbiol200415246235No
62025412541.053.653.6Interleukin-12 and the regulation of innate resistance and adaptive immunity. Giorgio TrinchieriNat Rev Immunol200312563297No
62125412541.052.5252.5Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Shimon SakaguchiAnnu Rev Immunol200415032588No
62225402540.055.1355.1G1 phase progression: cycling on cue. C J SherrCell19947954821No
62325392539.062.8862.9Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. E C ButcherCell19911760836No
62425322532.052.852.8The danger model: a renewed sense of self. Polly MatzingerScience200211951032Yes
62525312531.072.4972.5Delayed neuronal death in the gerbil hippocampus following ischemia. T KirinoBrain Res19827093691Yes
626227522528.0647.5872.0The Sequence Alignment/Map format and SAMtools. Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard DurbinBioinformatics200919505943Yes
62725172517.080.5280.5What are the functional consequences of neurocognitive deficits in schizophrenia? M F GreenAm J Psychiatry19968610818No
62850342517.0111.4655.7Emergence of scaling in random networks Barabasi, AlbertScience199910521342Yes
62925072507.077.6577.7Secretory products of macrophages. C F NathanJ Clin Invest19873543052No
63025032503.066.8966.9The resurgence of platinum-based cancer chemotherapy. Lloyd KellandNat Rev Cancer200717625587No
63149992499.50.00.0Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. J Sedlak, R H LindsayAnal Biochem19684973948Yes
63249922496.0105.0952.5Innate immune recognition. Charles A Janeway, Ruslan MedzhitovAnnu Rev Immunol200211861602No
63349902495.0158.5779.3The L-arginine-nitric oxide pathway. S Moncada, A HiggsN Engl J Med19937504210No
63424932493.067.4767.5Predictive reward signal of dopamine neurons. W SchultzJ Neurophysiol19989658025No
63549852492.5156.5478.3Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. K Tamura, M NeiMol Biol Evol19938336541Yes
63674722490.7172.0357.3The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. R C Lee, R L Feinbaum, V AmbrosCell19938252621Yes
63749792489.50.00.0Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. P J Fraker, J C SpeckBiochem Biophys Res Commun1978637870Yes
63849762488.00.00.0A diagnostic interview: the schedule for affective disorders and schizophrenia. J Endicott, R L SpitzerArch Gen Psychiatry1978678037Yes
63949762488.0174.3287.2mTOR signaling in growth control and disease. Mathieu Laplante, David M SabatiniCell201222500797No
64024862486.050.7650.8Universal control mechanism regulating onset of M-phase. P NurseNature19902138713No
64124862486.00.00.0Elastic properties of lipid bilayers: theory and possible experiments. W HelfrichZ Naturforsch C19734273690Yes
64249652482.50.00.0The Social Readjustment Rating Scale. T H Holmes, R H RaheJ Psychosom Res19676059863Yes
64349652482.5151.3175.7The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Taro Kawai, Shizuo AkiraNat Immunol201020404851No
64424822482.00.00.0On the number of segregating sites in genetical models without recombination. G A WattersonTheor Popul Biol19751145509Yes
64524822482.060.3360.3Memory--a century of consolidation. J L McGaughScience200010634773No
64649502475.0172.1486.1Computed tomography--an increasing source of radiation exposure. David J Brenner, Eric J HallN Engl J Med200718046031No
64724732473.00.00.0Oxygen-dependent microbial killing by phagocytes (first of two parts). B M BabiorN Engl J Med197824176Yes
64824712471.00.00.0The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin. M L AnsonJ Gen Physiol193819873094Yes
64924682468.00.00.0The catecholamine hypothesis of affective disorders: a review of supporting evidence. J J SchildkrautAm J Psychiatry19655319766No
65049302465.0176.8188.4The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Stephen B Edge, Carolyn C ComptonAnn Surg Oncol201020180029No
65198522463.0367.0191.8A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge KriegJ Chem Phys201020423165Yes
65224612461.0109.24109.2FreeSurfer. Bruce FischlNeuroimage201222248573No
653196762459.5449.056.1The Protein Data Bank. H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E BourneNucleic Acids Res200010592235Yes
65424582458.00.00.0The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. S BoydenJ Exp Med196213872176Yes
65524512451.00.00.0Models for the specific adhesion of cells to cells. G I BellScience1978347575No
65624502450.058.2458.2Prostaglandins and leukotrienes: advances in eicosanoid biology. C D FunkScience200111729303No
65748892444.5132.6666.3Exploring the full spectrum of macrophage activation. David M Mosser, Justin P EdwardsNat Rev Immunol200819029990No
65897372434.2303.2575.8Establishing a standard definition for child overweight and obesity worldwide: international survey. T J Cole, M C Bellizzi, K M Flegal, W H DietzBMJ200010797032Yes
65972862428.7286.7495.6Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Allison Tong, Peter Sainsbury, Jonathan CraigInt J Qual Health Care200717872937Yes
66024282428.055.4655.5Social controls on cell survival and cell death. M C RaffNature19921557121No
66148472423.5108.3154.2Inflammation and cancer: back to Virchow? F Balkwill, A MantovaniLancet200111229684No
66248352417.5197.298.6A feature-integration theory of attention. A M Treisman, G GeladeCogn Psychol19807351125Yes
66372512417.0220.6873.6Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. G Evanno, S Regnaut, J GoudetMol Ecol200515969739Yes
66424032403.00.00.0Transduction of linked genetic characters of the host by bacteriophage P1. E S LennoxVirology195513267987Yes
66524022402.088.588.5Measures of reliability in sports medicine and science. W G HopkinsSports Med200010907753Yes
66648032401.5145.6272.8Adherence to medication. Lars Osterberg, Terrence BlaschkeN Engl J Med200516079372No
66724002400.065.5965.6Dominant forces in protein folding. K A DillBiochemistry19902207096No
66823972397.054.2854.3Bone resorption by osteoclasts. S L TeitelbaumScience200010968780No
66923942394.063.6163.6The genetic legacy of the Quaternary ice ages. G HewittNature200010879524No
67023912391.092.6392.6Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. Joseph P WeirJ Strength Cond Res200515705040No
67123872387.00.00.0Perceived exertion as an indicator of somatic stress. G BorgScand J Rehabil Med19705523831Yes
67247732386.5115.5957.8Calculation of protein extinction coefficients from amino acid sequence data. S C Gill, P H von HippelAnal Biochem19892610349Yes
67323862386.065.465.4Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. H G GratznerScience19827123245Yes
67447712385.50.00.0Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. J V Durnin, J WomersleyBr J Nutr19744843734Yes
67547702385.0156.9578.5Complex brain networks: graph theoretical analysis of structural and functional systems. Ed Bullmore, Olaf SpornsNat Rev Neurosci200919190637No
67647682384.00.00.0Electrochemical photolysis of water at a semiconductor electrode. A Fujishima, K HondaNature197212635268Yes
67723822382.00.00.0Satellite cell of skeletal muscle fibers. A MauroJ Biophys Biochem Cytol196113768451Yes
67823812381.067.6867.7Cellular and molecular mechanisms of fibrosis. T A WynnJ Pathol200818161745No
67923682368.00.00.0Electroimmuno assay. C B LaurellScand J Clin Lab Invest Suppl19724114358Yes
68047292364.5157.2778.6The neural basis of drug craving: an incentive-sensitization theory of addiction. T E Robinson, K C BerridgeBrain Res Brain Res Rev19938401595No
68123642364.00.00.0A rapid radiochemical method for the determination of choline acetyltransferase. F FonnumJ Neurochem19751113118Yes
68270862362.0177.0559.0Pathogen recognition and innate immunity. Shizuo Akira, Satoshi Uematsu, Osamu TakeuchiCell200616497588No
68323592359.057.7957.8Vascular endothelial growth factor: basic science and clinical progress. Napoleone FerraraEndocr Rev200415294883No
68494292357.2496.67124.2Cancer statistics, 2014. Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin JemalCA Cancer J Clin201424399786Yes
68523552355.00.00.0Colorimetric assay of catalase. A K SinhaAnal Biochem19724556490Yes
68623542354.091.3491.3You want to measure coping but your protocol's too long: consider the brief COPE. C S CarverInt J Behav Med199716250744Yes
68746992349.594.6747.3CDK inhibitors: positive and negative regulators of G1-phase progression. C J Sherr, J M RobertsGenes Dev199910385618No
68846952347.50.00.0Screening lambdagt recombinant clones by hybridization to single plaques in situ. W D Benton, R W DavisScience1977322279Yes
68946912345.596.8448.4Untangling the ErbB signalling network. Y Yarden, M X SliwkowskiNat Rev Mol Cell Biol200111252954No
69046892344.50.00.0Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. S Marklund, G MarklundEur J Biochem19744215654Yes
69146892344.5133.9967.0Unified segmentation. John Ashburner, Karl J FristonNeuroimage200515955494Yes
69223432343.057.3557.4Autophagy: process and function. Noboru MizushimaGenes Dev200718006683No
69323432343.057.8257.8Epigenetics in cancer. Manel EstellerN Engl J Med200818337604No
69446792339.50.00.0A general method applicable to the search for similarities in the amino acid sequence of two proteins. S B Needleman, C D WunschJ Mol Biol19705420325Yes
69523392339.061.5961.6Cancer nanotechnology: opportunities and challenges. Mauro FerrariNat Rev Cancer200515738981No
69623292329.00.00.0The glomerular permeability determined by dextran clearance using Sephadex gel filtration. C E MogensenScand J Clin Lab Invest19685637478Yes
69723282328.055.9756.0Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. G P SmithScience19854001944Yes
69846502325.00.00.0Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. R A Laskey, A D MillsEur J Biochem19751175627Yes
69923172317.085.9986.0Calmodulin plays a pivotal role in cellular regulation. W Y CheungScience19806243188No
70023162316.045.5245.5Getting started with yeast. F ShermanMethods Enzymol19912005794Yes
70123162316.00.00.0Application of a microtechnique to viral serological investigations. J L SeverJ Immunol196213910995Yes
70246252312.50.00.0Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. J D Watson, F H CrickNature195313054692Yes
70323112311.053.8153.8Salt and drought stress signal transduction in plants. Jian-Kang ZhuAnnu Rev Plant Biol200212221975No
70446192309.5118.8259.4Autophagy in the pathogenesis of disease. Beth Levine, Guido KroemerCell200818191218No
70523042304.051.3551.4Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. T HunterCell19957834742No
70646072303.50.00.0Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion. J Silness, H LoeActa Odontol Scand196414158464Yes
70722992299.00.00.0The Michigan alcoholism screening test: the quest for a new diagnostic instrument. M L SelzerAm J Psychiatry19715565851Yes
70822992299.053.7453.7A decade of molecular biology of retinoic acid receptors. P ChambonFASEB J19968801176No
70945972298.599.7549.9MicroRNAs: small RNAs with a big role in gene regulation. Lin He, Gregory J HannonNat Rev Genet200415211354No
71022982298.054.1254.1Angiogenesis in life, disease and medicine. Peter CarmelietNature200516355210No
71122972297.00.00.0Inositol phospholipids and cell surface receptor function. R H MichellBiochim Biophys Acta1975164246No
71222902290.066.3766.4Interleukin-1 and interleukin-1 antagonism. C A DinarelloBlood19911826616No
71322902290.057.3957.4Bcl-2 and the regulation of programmed cell death. J C ReedJ Cell Biol19948294493No
71422902290.071.0371.0RELION: implementation of a Bayesian approach to cryo-EM structure determination. Sjors H W ScheresJ Struct Biol201223000701Yes
71522892289.051.4751.5The structure and regulation of protein phosphatases. P CohenAnnu Rev Biochem19892549856No
71622892289.089.4789.5What is value in health care? Michael E PorterN Engl J Med201021142528Yes
71745722286.0104.5952.3Death receptors: signaling and modulation. A Ashkenazi, V M DixitScience19989721089No
71822862286.00.00.0Muscle structure and theories of contraction. A F HuxleyProg Biophys Biophys Chem195713485191Yes
71945622281.00.00.0High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. M N Berry, D S FriendJ Cell Biol19694900611Yes
72045492274.5234.6117.3GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. Rod Peakall, Peter E SmouseBioinformatics201222820204Yes
72122692269.050.1150.1Evolving concepts of rheumatoid arthritis. Gary S FiresteinNature200312748655No
72245352267.5207.68103.8The qualitative content analysis process. Satu Elo, Helvi KyngäsJ Adv Nurs200818352969Yes
72322652265.045.7145.7SV40-transformed simian cells support the replication of early SV40 mutants. Y GluzmanCell19816260373Yes
72422652265.062.4362.4The magical number 4 in short-term memory: a reconsideration of mental storage capacity. N CowanBehav Brain Sci200111515286Yes
72522622262.00.00.0Separation of leukocytes from blood and bone marrow. Introduction. A BöyumScand J Clin Lab Invest Suppl19685707208Yes
72622582258.066.2966.3Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. P CorreaCancer Res19921458460No
72722552255.076.5576.5Glutamate, nitric oxide and cell-cell signalling in the nervous system. J GarthwaiteTrends Neurosci19911708538No
72844892244.5103.0751.5A simple and very efficient method for generating cDNA libraries. U Gubler, B J HoffmanGene19836198242Yes
72922442244.094.7994.8Qualitative research. Introducing focus groups. J KitzingerBMJ19957633241Yes
73067312243.7135.0445.0Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Ron Edgar, Michael Domrachev, Alex E LashNucleic Acids Res200211752295Yes
73122432243.00.00.0Stereochemistry of cooperative effects in haemoglobin. M F PerutzNature19705528785Yes
73267232241.00.00.0On The Nature Of Allosteric Transitions: A Plausible Model. J Monod, J Wyman, J P ChangeuxJ Mol Biol196514343300Yes
73322392239.055.9455.9Calcium signaling. David E ClaphamCell200718083096No
73444732236.593.7746.9Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. D Bonnet, J E DickNat Med19979212098Yes
73544732236.5161.3780.7Complex network measures of brain connectivity: uses and interpretations. Mikail Rubinov, Olaf SpornsNeuroimage201019819337Yes
73622362236.00.00.0Evaluating the quality of medical care. A DonabedianMilbank Mem Fund Q19665338568No
73722362236.094.5794.6The Danish Civil Registration System. Carsten Bøcker PedersenScand J Public Health201121775345Yes
73844712235.590.9945.5The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Igor Vivanco, Charles L SawyersNat Rev Cancer200212094235No
73944662233.091.9246.0Lipid rafts and signal transduction. K Simons, D ToomreNat Rev Mol Cell Biol200011413487No
74044642232.0139.8469.9Rapid isolation of high molecular weight plant DNA. M G Murray, W F ThompsonNucleic Acids Res19807433111Yes
74144592229.584.6642.3A novel genetic system to detect protein-protein interactions. S Fields, O SongNature19892547163Yes
74222292229.051.5551.5Mitochondrial diseases in man and mouse. D C WallaceScience199910066162No
74344552227.50.00.0The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J A Spudich, S WattJ Biol Chem19714254541Yes
74422272227.046.9947.0Tumour-educated macrophages promote tumour progression and metastasis. Jeffrey W PollardNat Rev Cancer200414708027No
74522232223.055.1355.1Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J Kyhse-AndersenJ Biochem Biophys Methods19846530509Yes
74644462223.0123.561.8Management of hepatocellular carcinoma. Jordi Bruix, Morris ShermanHepatology200516250051No
74722212221.00.00.0Removal of fatty acids from serum albumin by charcoal treatment. R F ChenJ Biol Chem19676016603Yes
74822212221.055.3755.4MapChart: software for the graphical presentation of linkage maps and QTLs. R E VoorripsJ Hered200212011185Yes
74922192219.056.0356.0A model for receptor-regulated calcium entry. J W PutneyCell Calcium19862420465No
75044352217.599.5749.8Organization and expression of eucaryotic split genes coding for proteins. R Breathnach, P ChambonAnnu Rev Biochem19816791577No
75122162216.00.00.0Mechanisms of action of transmitters and other substances on smooth muscle. T B BoltonPhysiol Rev197937533No
75222162216.053.3953.4Mechanisms and genes of cellular suicide. H StellerScience19957878463No
75322122212.050.1350.1Chemokines and leukocyte traffic. M BaggioliniNature19989560152No
75422122212.00.00.0The information capacity of the human motor system in controlling the amplitude of movement. P M FittsJ Exp Psychol195413174710Yes
75522102210.070.9971.0Reactive oxygen species and the central nervous system. B HalliwellJ Neurochem19921402908No
75622092209.085.4485.4Role of endothelium in responses of vascular smooth muscle. R F FurchgottCirc Res19836313250No
75744172208.5116.4758.2Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Weizhong Li, Adam GodzikBioinformatics200616731699Yes
75822082208.059.059.0A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. P ChomczynskiBiotechniques19937692896Yes
75922062206.053.5453.5Protein kinase C and lipid signaling for sustained cellular responses. Y NishizukaFASEB J19957737456No
76022042204.075.6175.6Accelerated Profile HMM Searches. Sean R EddyPLoS Comput Biol201122039361Yes
76144052202.5120.9260.5Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Marie-Christine Daniel, Didier AstrucChem Rev200414719978No
76222012201.061.7161.7Molecular diversity of glutamate receptors and implications for brain function. S NakanishiScience19921329206No
76322012201.078.6878.7Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. B N AmesScience19836351251No
76421982198.00.00.0The plasma lecithins:cholesterol acyltransferase reaction. J A GlomsetJ Lipid Res19684868699No
76521982198.049.1849.2Molecular physiology of P2X receptors. R Alan NorthPhysiol Rev200212270951No
76621982198.058.5158.5Causes and consequences of microRNA dysregulation in cancer. Carlo M CroceNat Rev Genet200919763153No
76743932196.50.00.0The interpretation of protein structures: estimation of static accessibility. B Lee, F M RichardsJ Mol Biol19715551392Yes
76821952195.070.1770.2SF-36 health survey update. J E WareSpine (Phila Pa 1976)200011124729No
76943862193.00.00.0On the size of the active site in proteases. I. Papain. I Schechter, A BergerBiochem Biophys Res Commun19676035483Yes
77021922192.00.00.0[Rapid physiological coagulation method in determination of fibrinogen]. A ClaussActa Haematol195713434757Yes
77143692184.5115.4457.7A receptor-mediated pathway for cholesterol homeostasis. M S Brown, J L GoldsteinScience19863513311No
77221822182.065.5465.5Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. M LeavittMedGenMed200111549951No
77321812181.068.0768.1Prooxidant states and tumor promotion. P A CeruttiScience19852981433No
77465402180.0364.39121.5Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. P J Van Soest, J B Robertson, B A LewisJ Dairy Sci19911660498No
77543592179.50.00.0A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. J E TILL, E A McCULLOCHRadiat Res196113776896Yes
77621792179.068.1268.1Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. R A DeFronzoDiabetes19883289989No
77721752175.00.00.0A new specific color reaction of hexuronic acids. Z DischeJ Biol Chem194720281638Yes
77843452172.50.00.0Periodontal Disease In Pregnancy. I. Prevalence And Severity. H Loe, J SilnessActa Odontol Scand196314121956Yes
77921722172.079.2679.3A computational approach to edge detection. J CannyIEEE Trans Pattern Anal Mach Intell198621869365Yes
78043352167.5148.3174.2Random-effects models for longitudinal data. N M Laird, J H WareBiometrics19827168798Yes
78143342167.095.547.8New functions for the matrix metalloproteinases in cancer progression. Mikala Egeblad, Zena WerbNat Rev Cancer200211990853No
78221672167.071.7271.7adegenet: a R package for the multivariate analysis of genetic markers. Thibaut JombartBioinformatics200818397895Yes
78321662166.056.0556.0Molecular basis of bacterial outer membrane permeability revisited. Hiroshi NikaidoMicrobiol Mol Biol Rev200314665678No
78421632163.053.7753.8Ischemic cell death in brain neurons. P LiptonPhysiol Rev199910508238No
78543232161.5218.57109.3Stress, social support, and the buffering hypothesis. S Cohen, T A WillsPsychol Bull19853901065No
78643142157.0128.7564.4Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. C J Murray, A D LopezLancet19979167458Yes
78721562156.048.4648.5The regulation of AP-1 activity by mitogen-activated protein kinases. M KarinJ Biol Chem19957622446No
78821542154.00.00.0Sedimentation Studies Of The Size And Shape Of Dna. F W StudierJ Mol Biol196514290352Yes
78921532153.049.3149.3Chemokines. B J RollinsBlood19979242519No
79021532153.065.0565.0Two-sided confidence intervals for the single proportion: comparison of seven methods. R G NewcombeStat Med19989595616Yes
79164512150.3210.5870.2Arlequin (version 3.0): an integrated software package for population genetics data analysis. Laurent Excoffier, Guillaume Laval, Stefan SchneiderEvol Bioinform Online200719325852Yes
79221502150.079.8379.8Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. H W SteinbuschNeuroscience19817017455Yes
79321472147.066.2766.3Diagnosis of Alzheimer's disease. Z S KhachaturianArch Neurol19852864910Yes
79421432143.00.00.0The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. W W ClelandBiochim Biophys Acta196314021667Yes
79542842142.095.8547.9Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. F Sallusto, A LanzavecchiaJ Exp Med19948145033Yes
79621422142.042.042.0Java Treeview--extensible visualization of microarray data. Alok J SaldanhaBioinformatics200415180930Yes
79742742137.00.00.0The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. H P Misra, I FridovichJ Biol Chem19724623845Yes
79842742137.0131.0865.5Neural mechanisms of selective visual attention. R Desimone, J DuncanAnnu Rev Neurosci19957605061No
79942742137.099.6549.8The Bcl-2 protein family: arbiters of cell survival. J M Adams, S CoryScience19989735050No
80021352135.057.6857.7Dietary pattern analysis: a new direction in nutritional epidemiology. Frank B HuCurr Opin Lipidol200211790957No
801128052134.2317.4252.9Phaser crystallographic software. Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J ReadJ Appl Crystallogr200719461840Yes
80242672133.5139.1169.6Accurate and simple analytic representation of the electron-gas correlation energy. Perdew, WangPhys Rev B Condens Matter199210001404Yes
80363992133.0150.7950.3The biology of VEGF and its receptors. Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouterNat Med200312778165No
80421312131.00.00.0A Rationale And Test For The Number Of Factors In Factor Analysis. J L HornPsychometrika196514306381Yes
80521302130.085.8285.8Effective physician-patient communication and health outcomes: a review. M A StewartCMAJ19957728691Yes
80642532126.5116.7358.4Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. C W Elston, I O EllisHistopathology19911757079Yes
80742512125.50.00.0A Simplified Lead Citrate Stain For Use In Electron Microscopy. J H Venable, R CoggeshallJ Cell Biol196514287192Yes
80842442122.0126.6363.3Pattern recognition receptors and inflammation. Osamu Takeuchi, Shizuo AkiraCell201020303872No
80921212121.042.0342.0Protein modules and signalling networks. T PawsonNature19957531822No
81021202120.063.9263.9Scaffolds in tissue engineering bone and cartilage. D W HutmacherBiomaterials200011071603Yes
81121192119.00.00.0Intracellular aspects of the process of protein synthesis. G PaladeScience19751096303No
81221192119.040.9841.0Histone acetylation in chromatin structure and transcription. M GrunsteinNature19979311776No
81342312115.5194.3897.2Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. N S Jacobson, P TruaxJ Consult Clin Psychol19912002127Yes
81421122112.049.6549.6A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Douglas C WallaceAnnu Rev Genet200516285865No
81521112111.041.2141.2Targeting RAS signalling pathways in cancer therapy. Julian DownwardNat Rev Cancer200312509763No
81621102110.00.00.0Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. D AminoffBiochem J196113860975Yes
81721092109.046.1646.2Telomere measurement by quantitative PCR. Richard M CawthonNucleic Acids Res200212000852Yes
81863172105.7188.8763.0Bacterial biofilms: a common cause of persistent infections. J W Costerton, P S Stewart, E P GreenbergScience199910334980No
81942082104.0106.7453.4Function and activation of NF-kappa B in the immune system. P A Baeuerle, T HenkelAnnu Rev Immunol19948011280No
82084062101.5276.5169.1Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Qiong Wang, George M Garrity, James M Tiedje, James R ColeAppl Environ Microbiol200717586664Yes
82121012101.079.8479.8Specific impairments of planning. T ShallicePhilos Trans R Soc Lond B Biol Sci19826125971Yes
82221002100.050.150.1Patterns of amino acids near signal-sequence cleavage sites. G von HeijneEur J Biochem19836852022Yes
82341992099.5105.352.6Regulation of the mevalonate pathway. J L Goldstein, M S BrownNature19901967820No
82420982098.088.3488.3A systematic method for clinical description and classification of personality variants. A proposal. C R CloningerArch Gen Psychiatry19873579504Yes
82520982098.0116.12116.1Interrater reliability: the kappa statistic. Mary L McHughBiochem Med (Zagreb)201223092060Yes
82641932096.594.6147.3Mass spectrometry-based proteomics. Ruedi Aebersold, Matthias MannNature200312634793No
82741912095.5100.1150.1Assembly of asparagine-linked oligosaccharides. R Kornfeld, S KornfeldAnnu Rev Biochem19853896128No
82841912095.5165.4182.7FLASH: fast length adjustment of short reads to improve genome assemblies. Tanja Magoč, Steven L SalzbergBioinformatics201121903629Yes
82941892094.50.00.0Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. R B Devereux, N ReichekCirculation1977138494Yes
83041892094.5102.1551.1Signal integration in the endoplasmic reticulum unfolded protein response. David Ron, Peter WalterNat Rev Mol Cell Biol200717565364No
83120912091.050.150.1Specification of cerebral cortical areas. P RakicScience19883291116No
83220902090.00.00.0The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. D E AtkinsonBiochemistry19684972613Yes
83383492087.2246.061.5GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. Berk Hess, Carsten Kutzner, David van der Spoel, Erik LindahlJ Chem Theory Comput200826620784Yes
83420872087.049.4349.4Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. G TrinchieriAnnu Rev Immunol19957612223No
83541742087.085.8142.9Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Yigong Shi, Joan MassaguéCell200312809600No
83641712085.5122.6361.3Distributed hierarchical processing in the primate cerebral cortex. D J Felleman, D C Van EssenCereb Cortex19911822724No
83741692084.50.00.0Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. T V Bliss, T LomoJ Physiol19734727084Yes
83841652082.5148.7574.4The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. S H Downs, N BlackJ Epidemiol Community Health19989764259Yes
83920822082.044.6844.7Mammalian G1 cyclins. C J SherrCell19938513492No
84041632081.5154.1677.1The attention system of the human brain. M I Posner, S E PetersenAnnu Rev Neurosci19902183676No
84141622081.0120.6260.3Angiogenic factors. J Folkman, M KlagsbrunScience19872432664No
84220802080.046.9947.0NOX enzymes and the biology of reactive oxygen. J David LambethNat Rev Immunol200415039755No
84362392079.7285.0295.0Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. J L Cox, J M Holden, R SagovskyBr J Psychiatry19873651732Yes
84420792079.063.6763.7Physiology and neurobiology of stress and adaptation: central role of the brain. Bruce S McEwenPhysiol Rev200717615391No
84520762076.00.00.0Method For Assay Of Intestinal Disaccharidases. A DahlqvistAnal Biochem196414106916Yes
84662272075.70.00.0Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. B N Ames, J Mccann, E YamasakiMutat Res1975768755Yes
84741462073.0107.5353.8Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. E Lander, L KruglyakNat Genet19957581446Yes
848165842073.0541.067.6The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C SiebertN Engl J Med19938366922Yes
84941462073.0123.0961.5Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. J S Beckman, W H KoppenolAm J Physiol19968944624No
85020722072.043.1443.1The molecular biology of memory storage: a dialogue between genes and synapses. E R KandelScience200111691980No
85120682068.052.6152.6Modularity and community structure in networks. M E J NewmanProc Natl Acad Sci U S A200616723398Yes
85241352067.5434.4217.2A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. Terry K Koo, Mae Y LiJ Chiropr Med201627330520Yes
85320652065.0122.57122.6Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Daniël LakensFront Psychol201324324449No
85420642064.00.00.0Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. F F JöbsisScience1977929199Yes
85520632063.00.00.0Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane. J C SkouPhysiol Rev196514337569No
85620622062.00.00.0Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants. J W LittlefieldScience196414168277Yes
85720602060.063.263.2The unbiased estimation of number and sizes of arbitrary particles using the disector. D C SterioJ Microsc19846737468Yes
85861782059.3366.78122.3Deep learning. Yann LeCun, Yoshua Bengio, Geoffrey HintonNature201526017442No
85961762058.7145.2248.4MOLMOL: a program for display and analysis of macromolecular structures. R Koradi, M Billeter, K WüthrichJ Mol Graph19968744573Yes
86020562056.053.8953.9Breast cancer and hormone-replacement therapy in the Million Women Study. Valerie BeralLancet200312927427Yes
86120552055.057.8857.9Immunological and inflammatory functions of the interleukin-1 family. Charles A DinarelloAnnu Rev Immunol200919302047No
86241082054.0157.7478.9Self-rated health and mortality: a review of twenty-seven community studies. E L Idler, Y BenyaminiJ Health Soc Behav19979097506No
86341072053.587.6543.8A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. G Shaw, R KamenCell19863488815Yes
86420532053.051.1651.2The anatomy and taxonomy of protein structure. J S RichardsonAdv Protein Chem19817020376No
86520492049.053.6753.7A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Pascal FriesTrends Cogn Sci200516150631No
86620492049.00.00.0Isolation by Distance. S WrightGenetics194317247074Yes
86720482048.045.845.8Cisplatin: mode of cytotoxic action and molecular basis of resistance. Zahid H SiddikOncogene200314576837No
86840962048.0108.3254.2Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Klaus Apel, Heribert HirtAnnu Rev Plant Biol200415377225No
86940952047.50.00.0Plaque formation and isolation of pure lines with poliomyelitis viruses. R Dulbecco, M VogtJ Exp Med195413130792Yes
87061422047.3181.1960.4Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. C E Murry, R B Jennings, K A ReimerCirculation19863769170Yes
87120442044.063.2263.2A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. Heng LiBioinformatics201121903627Yes
87240762038.0104.1152.1Protein misfolding, functional amyloid, and human disease. Fabrizio Chiti, Christopher M DobsonAnnu Rev Biochem200616756495No
87320362036.00.00.0Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices. T HiguchiJ Pharm Sci196314088963Yes
87420342034.042.5742.6G1 events and regulation of cell proliferation. A B PardeeScience19892683075No
87561002033.30.00.0Immunochemical quantitation of antigens by single radial immunodiffusion. G Mancini, A O Carbonara, J F HeremansImmunochemistry19654956917Yes
87640662033.0128.1964.1Missing data: our view of the state of the art. Joseph L Schafer, John W GrahamPsychol Methods200212090408Yes
87740602030.098.1849.1AKT/PKB signaling: navigating downstream. Brendan D Manning, Lewis C CantleyCell200717604717No
87840572028.5100.1950.1Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. P Liang, A B PardeeScience19921354393Yes
87960812027.0171.4757.2RNA-Seq: a revolutionary tool for transcriptomics. Zhong Wang, Mark Gerstein, Michael SnyderNat Rev Genet200919015660No
88020252025.00.00.0Antigen-antibody reactions in gels. O OuchterlonyActa Pathol Microbiol Scand194918143039Yes
88140482024.0107.0853.5Acute-phase proteins and other systemic responses to inflammation. C Gabay, I KushnerN Engl J Med19999971870No
88220222022.00.00.0Analysis of bacteriophage T7 early RNAs and proteins on slab gels. F W StudierJ Mol Biol19734760132Yes
88360632021.00.00.0Glucose clamp technique: a method for quantifying insulin secretion and resistance. R A DeFronzo, J D Tobin, R AndresAm J Physiol1979382871Yes
88420212021.069.0469.0A classification of glycosyl hydrolases based on amino acid sequence similarities. B HenrissatBiochem J19911747104Yes
88520212021.052.0752.1RGD and other recognition sequences for integrins. E RuoslahtiAnnu Rev Cell Dev Biol19968970741No
88620212021.070.470.4Ethical authorship and publishing. Andrew J S CoatsInt J Cardiol200919046787No
88720192019.083.083.0A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. E L BradleyArch Surg19938489394No
88820172017.059.3459.3ATP-regulated K+ channels in cardiac muscle. A NomaNature19836310409Yes
88920162016.048.0548.0Interleukin-2: inception, impact, and implications. K A SmithScience19883131876No
89040182009.081.1740.6The fundamental role of epigenetic events in cancer. Peter A Jones, Stephen B BaylinNat Rev Genet200212042769No
89140162008.0208.31104.2phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. Paul J McMurdie, Susan HolmesPLoS One201323630581Yes
89240142007.0105.052.5A global optimisation method for robust affine registration of brain images. M Jenkinson, S SmithMed Image Anal200111516708Yes
89320052005.044.3144.3The mitogen-activated protein kinase signal transduction pathway. R J DavisJ Biol Chem19938325833No
89420042004.057.0857.1Superoxide radical and superoxide dismutases. I FridovichAnnu Rev Biochem19957574505No
89520022002.044.5444.5Structural design and molecular evolution of a cytokine receptor superfamily. J F BazanProc Natl Acad Sci U S A19902169613Yes
89620022002.067.267.2Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. W A CraigClin Infect Dis19989455502No
89720022002.043.1643.2Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Shimon SakaguchiNat Immunol200515785760No
89859971999.0178.5259.5Quantum mechanical continuum solvation models. Jacopo Tomasi, Benedetta Mennucci, Roberto CammiChem Rev200516092826Yes
89919991999.063.2763.3Parkinson's disease: clinical features and diagnosis. J JankovicJ Neurol Neurosurg Psychiatry200818344392No
90019981998.045.2345.2Nitric oxide and the immune response. C BogdanNat Immunol200111577346No
90119981998.067.1667.2Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Peter C AustinStat Med200919757444Yes
90219971997.067.6767.7Working memory. A BaddeleyScience19921736359No
90319941994.060.360.3Stress, adaptation, and disease. Allostasis and allostatic load. B S McEwenAnn N Y Acad Sci19989629234No
90419931993.047.8347.8Calcium signaling. D E ClaphamCell19957834745No
90519931993.042.9142.9XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. D E McReeJ Struct Biol199910222271Yes
90619931993.076.1276.1DNA methylation age of human tissues and cell types. Steve HorvathGenome Biol201324138928Yes
90719911991.00.00.0The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. U E LoeningBiochem J19675339944Yes
90839801990.0132.5966.3Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. R M Ryan, E L DeciAm Psychol200011392867Yes
90919891989.094.2994.3Structural Model Evaluation and Modification: An Interval Estimation Approach. J H SteigerMultivariate Behav Res199026794479Yes
91019881988.00.00.0Presidential Address-1976. Social support as a moderator of life stress. S CobbPsychosom Med1976981490Yes
91139751987.5109.2954.6The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Karen Bedard, Karl-Heinz KrausePhysiol Rev200717237347No
91219861986.00.00.0Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. P MitchellBiol Rev Camb Philos Soc19665329743No
91319861986.045.1445.1Complement. First of two parts. M J WalportN Engl J Med200111287977No
91439701985.080.0940.0Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. M Gossen, H BujardProc Natl Acad Sci U S A19921319065Yes
91539701985.0108.8954.4New perspectives in cell adhesion: RGD and integrins. E Ruoslahti, M D PierschbacherScience19872821619No
91619841984.053.6653.7The molecular pathology of Alzheimer's disease. D J SelkoeNeuron19911673054No
91719821982.083.083.0Role of Streptococcus mutans in human dental decay. W J LoescheMicrobiol Rev19863540569No
91839621981.00.00.0Loss of recent memory after bilateral hippocampal lesions. W B Scoville, B MilnerJ Neurol Neurosurg Psychiatry195713406589Yes
91939581979.0127.0563.5SPSS and SAS procedures for estimating indirect effects in simple mediation models. Kristopher J Preacher, Andrew F HayesBehav Res Methods Instrum Comput200415641418Yes
92019771977.053.1353.1The heme oxygenase system: a regulator of second messenger gases. M D MainesAnnu Rev Pharmacol Toxicol19979131263No
92119751975.066.8866.9Biodiesel from microalgae. Yusuf ChistiBiotechnol Adv200717350212No
92219731973.058.6958.7Formation and Structure of Self-Assembled Monolayers. Abraham UlmanChem Rev199611848802Yes
92319691969.062.5662.6Hybrid porous solids: past, present, future. Gérard FéreyChem Soc Rev200818197340Yes
92439371968.5104.0652.0The heat-shock proteins. S Lindquist, E A CraigAnnu Rev Genet19882853609No
92539371968.50.00.0Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol. W R Morrison, L M SmithJ Lipid Res196414221106Yes
92619681968.048.1148.1The inflammatory reflex. Kevin J TraceyNature200212490958No
92739351967.5104.6152.3Myeloid-derived suppressor cells as regulators of the immune system. Dmitry I Gabrilovich, Srinivas NagarajNat Rev Immunol200919197294No
92839291964.5112.1156.1A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Y Matsumura, H MaedaCancer Res19862946403Yes
92919611961.057.957.9Protein oxidation and aging. E R StadtmanScience19921355616No
93019591959.053.753.7Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. J FolkmanN Engl J Med19957491141No
93158771959.0163.3254.4ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Kai Wang, Mingyao Li, Hakon HakonarsonNucleic Acids Res201020601685Yes
93219571957.00.00.0Purinergic nerves. G BurnstockPharmacol Rev19724404211No
93358671955.7121.540.5Rapid and efficient site-specific mutagenesis without phenotypic selection. T A Kunkel, J D Roberts, R A ZakourMethods Enzymol19873323813Yes
93439101955.00.00.0Genetic regulatory mechanisms in the synthesis of proteins. F Jacob, J MonodJ Mol Biol196113718526Yes
93519541954.00.00.0The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. S V BoydenJ Exp Med195114803635Yes
93619531953.065.3465.3Eye movements in reading and information processing: 20 years of research. K RaynerPsychol Bull19989849112No
93739061953.00.00.0A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. R F Beers, I W SizerJ Biol Chem195214938361Yes
93839021951.0100.4450.2Nonparametric permutation tests for functional neuroimaging: a primer with examples. Thomas E Nichols, Andrew P HolmesHum Brain Mapp200211747097Yes
93919511951.061.5361.5Efficient methods to compute genomic predictions. P M VanRadenJ Dairy Sci200818946147Yes
94019491949.055.1955.2The importance of selenium to human health. M P RaymanLancet200010963212No
94119491949.058.758.7Pancreatic cancer. Manuel HidalgoN Engl J Med201020427809No
94238941947.0116.1858.1Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Michael D Fox, Marcus E RaichleNat Rev Neurosci200717704812No
94319461946.039.4839.5Shelterin: the protein complex that shapes and safeguards human telomeres. Titia de LangeGenes Dev200516166375No
94419451945.039.4239.4NK cell recognition. Lewis L LanierAnnu Rev Immunol200515771571No
94519441944.061.361.3Fetal origins of coronary heart disease. D J BarkerBMJ19957613432No
94619431943.052.7252.7Descending control of pain. Mark J MillanProg Neurobiol200212034378No
94719421942.00.00.0Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. A FleckensteinAnnu Rev Pharmacol Toxicol1977326161No
94819421942.00.00.0Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. J P ChamberlainAnal Biochem1979543547Yes
94919421942.00.00.0The oxidation of ribonuclease with performic acid. C H HirsJ Biol Chem195613319283Yes
95019401940.054.3554.4The biology of interleukin-6. T KishimotoBlood19892473791No
95119401940.00.00.0Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. G BertaniJ Bacteriol195114888646Yes
95219401940.090.1590.2Central sensitization: implications for the diagnosis and treatment of pain. Clifford J WoolfPain201120961685No
95319391939.040.3540.4Mechanisms of intracellular protein transport. J E RothmanNature19947969419No
95419381938.069.6469.6Determination of glutathione and glutathione disulfide in biological samples. M E AndersonMethods Enzymol19854088074Yes
95538761938.095.9148.0Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. G G Glenner, C W WongBiochem Biophys Res Commun19846375662Yes
95638701935.00.00.0Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. I W McLean, P K NakaneJ Histochem Cytochem19744374474Yes
95738661933.080.6440.3Mammalian MAP kinase signalling cascades. L Chang, M KarinNature200111242034No
95819321932.066.366.3Human error: models and management. J ReasonBMJ200010720363Yes
95919311931.052.9252.9Working memory: looking back and looking forward. Alan BaddeleyNat Rev Neurosci200314523382No
96019311931.047.8547.9Rab GTPases as coordinators of vesicle traffic. Harald StenmarkNat Rev Mol Cell Biol200919603039No
96119301930.056.456.4Estimating causal effects from large data sets using propensity scores. D B RubinAnn Intern Med19979382394No
96219291929.057.7457.7Intracellular calcium homeostasis. E CarafoliAnnu Rev Biochem19873304139No
96319271927.049.7549.8Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Edward V LoftusGastroenterology200415168363Yes
964115511925.2265.5244.3NMRPipe: a multidimensional spectral processing system based on UNIX pipes. F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A BaxJ Biomol NMR19958520220Yes
96538491924.5108.4654.2Insulin-like growth factors and their binding proteins: biological actions. J I Jones, D R ClemmonsEndocr Rev19957758431No
96619241924.046.6746.7Pathways towards and away from Alzheimer's disease. Mark P MattsonNature200415295589No
96738461923.0125.9163.0A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Gary J Bennett, Y-K XiePain19882837713Yes
96838441922.092.3846.2Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. B A Reynolds, S WeissScience19921553558Yes
96957661922.0116.4838.8Control of regulatory T cell development by the transcription factor Foxp3. Shohei Hori, Takashi Nomura, Shimon SakaguchiScience200312522256Yes
97038431921.584.9242.5Lessons from hereditary colorectal cancer. K W Kinzler, B VogelsteinCell19968861899No
97119211921.035.5435.5ATM and related protein kinases: safeguarding genome integrity. Yosef ShilohNat Rev Cancer200312612651No
97238411920.5101.3650.7Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Hashem B El-Serag, K Lenhard RudolphGastroenterology200717570226No
97319201920.00.00.0Crystalline Soybean Trypsin Inhibitor : Ii. General Properties. M KunitzJ Gen Physiol194719873496Yes
97419191919.063.7363.7Spinal and supraspinal factors in human muscle fatigue. S C GandeviaPhysiol Rev200111581501No
97538381919.00.00.0Acetylornithinase of Escherichia coli: partial purification and some properties. H J Vogel, D M BonnerJ Biol Chem195613278318Yes
97638381919.00.00.0Judgment under Uncertainty: Heuristics and Biases. A Tversky, D KahnemanScience197417835457Yes
97738361918.00.00.0Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. A C Chang, S N CohenJ Bacteriol1978149110Yes
97819181918.040.7440.7A cell culture model for T lymphocyte clonal anergy. R H SchwartzScience19902113314Yes
97919171917.035.5335.5In situ hybridization: an improved whole-mount method for Xenopus embryos. R M HarlandMethods Cell Biol19911811161Yes
98019171917.059.9459.9A two process model of sleep regulation. A A BorbélyHum Neurobiol19827185792Yes
98119161916.041.4341.4Role of angiogenesis in tumor growth and metastasis. Judah FolkmanSemin Oncol200212516034No
98238301915.084.1542.1The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. A J Ridley, A HallCell19921643657Yes
98319121912.064.6664.7Plant products as antimicrobial agents. M M CowanClin Microbiol Rev199910515903No
98419121912.039.5139.5CpG motifs in bacterial DNA and their immune effects. Arthur M KriegAnnu Rev Immunol200211861616No
98519121912.050.2350.2Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. Jane GlazebrookAnnu Rev Phytopathol200516078883No
986114711911.8411.4868.6Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell ParkinInt J Cancer201021351269Yes
98719111911.074.3174.3Epidemiology of viral hepatitis and hepatocellular carcinoma. Hashem B El-SeragGastroenterology201222537432No
98838211910.5178.8989.4Stages and processes of self-change of smoking: toward an integrative model of change. J O Prochaska, C C DiClementeJ Consult Clin Psychol19836863699Yes
98919101910.047.1247.1DNA topoisomerases. J C WangAnnu Rev Biochem19852992360No
99038191909.5118.0759.0The number of people with glaucoma worldwide in 2010 and 2020. H A Quigley, A T BromanBr J Ophthalmol200616488940Yes
99138171908.5105.9953.0Alzheimer's disease: the amyloid cascade hypothesis. J A Hardy, G A HigginsScience19921566067No
99219081908.064.8664.9Intermediate filaments as mechanical integrators of cellular space. E LazaridesNature19807188712Yes
99319081908.071.2371.2International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. C HerrmannJ Psychosom Res19979055211No
99419081908.049.9650.0Inferring the historical patterns of biological evolution. M PagelNature199910553904Yes
99519071907.00.00.0Influences of glucose loading and of injected insulin on hepatic glucose output. R SteeleAnn N Y Acad Sci195913833973Yes
99619051905.00.00.0Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. D M NevilleJ Biol Chem19715127429Yes
99719041904.050.9450.9DNA topoisomerase poisons as antitumor drugs. L F LiuAnnu Rev Biochem19892549853No
99818991899.081.0581.0A rating scale for drug-induced akathisia. T R BarnesBr J Psychiatry19892574607Yes
99918991899.080.8880.9The validity and practicality of sun-reactive skin types I through VI. T B FitzpatrickArch Dermatol19883377516Yes
100056951898.3224.1274.7Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. G Muyzer, E C de Waal, A G UitterlindenAppl Environ Microbiol19937683183Yes
100156951898.3153.5151.2Cortical surface-based analysis. I. Segmentation and surface reconstruction. A M Dale, B Fischl, M I SerenoNeuroimage19999931268Yes
100237961898.0102.8751.4Inositol phosphates and cell signalling. M J Berridge, R F IrvineNature19892550825No
100337961898.0101.4550.7Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. M Matsuda, R A DeFronzoDiabetes Care199910480510Yes
100418971897.085.4385.4The Children's Depression, Inventory (CDI). M KovacsPsychopharmacol Bull19854089116Yes
100518971897.084.5184.5Brain dopamine receptors. P SeemanPharmacol Rev19806117090No
100618951895.00.00.0Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. A BreslowAnn Surg19705477666Yes
100718951895.00.00.0Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? J V NeelAm J Hum Genet196213937884Yes
100837891894.5106.8553.4UniFrac: a new phylogenetic method for comparing microbial communities. Catherine Lozupone, Rob KnightAppl Environ Microbiol200516332807Yes
100918931893.00.00.0In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. T R ChenExp Cell Res197765285Yes
101056751891.7192.764.2Parallel organization of functionally segregated circuits linking basal ganglia and cortex. G E Alexander, M R DeLong, P L StrickAnnu Rev Neurosci19863085570No
101118911891.00.00.0On estimating the relation between blood group and disease. B WoolfAnn Hum Genet195514388528Yes
101218911891.057.2557.2Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Claudiu T SupuranNat Rev Drug Discov200818167490No
101318861886.00.00.0Analysis of tissue and arterial blood temperatures in the resting human forearm. H H PennesJ Appl Physiol194818887578Yes
101456571885.7172.057.3Immunity, inflammation, and cancer. Sergei I Grivennikov, Florian R Greten, Michael KarinCell201020303878No
101537691884.595.7647.9Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. P J Barnes, M KarinN Engl J Med19979091804No
101618841884.042.8442.8Signal sequences. The limits of variation. G von HeijneJ Mol Biol19854032478Yes
101775321883.0173.1743.3Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. A Krogh, B Larsson, G von Heijne, E L SonnhammerJ Mol Biol200111152613Yes
101818831883.065.5665.6The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Claudio HetzNat Rev Mol Cell Biol201222251901No
101937651882.590.1645.1Base-calling of automated sequencer traces using phred. II. Error probabilities. B Ewing, P GreenGenome Res19989521922Yes
102018821882.00.00.0Complete nucleotide sequence of the Escherichia coli plasmid pBR322. J G SutcliffeCold Spring Harb Symp Quant Biol1979383387Yes
102118821882.056.9757.0Calbindin D-28k and parvalbumin in the rat nervous system. M R CelioNeuroscience19902199841Yes
102256451881.70.00.0Research diagnostic criteria: rationale and reliability. R L Spitzer, J Endicott, E RobinsArch Gen Psychiatry1978655775Yes
102318811881.00.00.0A modified card sorting test sensitive to frontal lobe defects. H E NelsonCortex19761009768Yes
102437621881.078.3939.2Network biology: understanding the cell's functional organization. Albert-László Barabási, Zoltán N OltvaiNat Rev Genet200414735121No
102537611880.50.00.0Variations in pattern of pubertal changes in girls. W A Marshall, J M TannerArch Dis Child19695785179Yes
102637601880.00.00.0An efficient mRNA-dependent translation system from reticulocyte lysates. H R Pelham, R J JacksonEur J Biochem1976823012Yes
102737601880.093.4546.7Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. M Nei, T GojoboriMol Biol Evol19863444411Yes
102818791879.053.053.0T cell exhaustion. E John WherryNat Immunol201121739672No
102918781878.054.7954.8Excitotoxic cell death. D W ChoiJ Neurobiol19921361523No
103018771877.065.6565.7Simplified calculation of body-surface area. R D MostellerN Engl J Med19873657876Yes
103118751875.040.1540.1Molecular bases for circadian clocks. J C DunlapCell19999988221No
103218741874.082.3682.4Missing data analysis: making it work in the real world. John W GrahamAnnu Rev Psychol200918652544No
103318731873.034.8834.9Signaling--2000 and beyond. T HunterCell200010647936No
103418731873.039.2239.2Mechanisms of type-I- and type-II-interferon-mediated signalling. Leonidas C PlataniasNat Rev Immunol200515864272No
103518701870.041.8441.8Biology of natural killer cells. G TrinchieriAdv Immunol19892683611No
103618701870.064.6964.7Qualitative research: standards, challenges, and guidelines. K MalterudLancet200111513933Yes
103718681868.00.00.0Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. S CohenJ Biol Chem196213880319Yes
103874701867.5188.1347.0p53 mutations in human cancers. M Hollstein, D Sidransky, B Vogelstein, C C HarrisScience19911905840No
103956011867.0141.2247.1GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. R A Jefferson, T A Kavanagh, M W BevanEMBO J19873327686Yes
104037271863.587.2543.6The Fas death factor. S Nagata, P GolsteinScience19957533326No
104118631863.055.1155.1Japanese Classification of Gastric Carcinoma - 2nd English Edition - Japanese Gastric Cancer AssociationGastric Cancer199811957040Yes
104237231861.5108.4254.2Application of phylogenetic networks in evolutionary studies. Daniel H Huson, David BryantMol Biol Evol200616221896Yes
104318591859.074.6574.7Approximate entropy as a measure of system complexity. S M PincusProc Natl Acad Sci U S A199111607165Yes
104418581858.048.6948.7Flow-mediated endothelial mechanotransduction. P F DaviesPhysiol Rev19957624393No
104537161858.096.448.2Leptin and the regulation of body weight in mammals. J M Friedman, J L HalaasNature19989796811No
104618571857.039.7439.7Metastasis to bone: causes, consequences and therapeutic opportunities. Gregory R MundyNat Rev Cancer200212154351No
104718571857.043.243.2Defensins: antimicrobial peptides of innate immunity. Tomas GanzNat Rev Immunol200312949495No
104837131856.581.1640.6Raster3D: photorealistic molecular graphics. E A Merritt, D J BaconMethods Enzymol199718488322Yes
104918561856.053.7853.8The blood-brain barrier in health and chronic neurodegenerative disorders. Berislav V ZlokovicNeuron200818215617No
105018551855.052.7852.8The episodic buffer: a new component of working memory? BaddeleyTrends Cogn Sci200011058819Yes
105137051852.50.00.0Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. J G Rheinwald, H GreenCell19751052771Yes
105237011850.5122.0761.0Oxygen toxicity, oxygen radicals, transition metals and disease. B Halliwell, J M GutteridgeBiochem J19846326753No
105318491849.039.1839.2The expanding role of mitochondria in apoptosis. X WangGenes Dev200111711427No
105418481848.056.1156.1The nuclear factor NF-kappaB pathway in inflammation. Toby LawrenceCold Spring Harb Perspect Biol200920457564No
105518441844.062.5362.5The use of a plus-maze to measure anxiety in the mouse. R G ListerPsychopharmacology (Berl)19873110839Yes
105636871843.50.00.0Immunoassay of insulin with insulin-antibody precipitate. C N Hales, P J RandleBiochem J196313952078Yes
105755301843.30.00.0A rapid method for the isolation of functional thymus-derived murine lymphocytes. M H Julius, E Simpson, L A HerzenbergEur J Immunol19734587740Yes
105818411841.045.3145.3Thioredoxin. A HolmgrenAnnu Rev Biochem19853896121No
105936811840.576.838.4Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Rudolf Jaenisch, Adrian BirdNat Genet200312610534No
106036741837.0107.3753.7Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. B J Marshall, J R WarrenLancet19846145023Yes
106136741837.084.6942.3Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. T Miyashita, J C ReedCell19957834749Yes
106218351835.051.451.4Epidemiology of insomnia: what we know and what we still need to learn. Maurice M OhayonSleep Med Rev200212531146Yes
106336691834.576.3738.2The Wnt signaling pathway in development and disease. Catriona Y Logan, Roel NusseAnnu Rev Cell Dev Biol200415473860No
106418341834.033.733.7The regulation of E2F by pRB-family proteins. N DysonGenes Dev19989694791No
106518321832.043.2643.3A clearer vision for in vivo imaging. R WeisslederNat Biotechnol200111283581No
106636571828.590.0345.0The future of genetic studies of complex human diseases. N Risch, K MerikangasScience19968801636Yes
106773111827.8256.2864.1Reporting results of cancer treatment. A B Miller, B Hoogstraten, M Staquet, A WinklerCancer19817459811Yes
106873071826.8192.7148.2Matrix elasticity directs stem cell lineage specification. Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E DischerCell200616923388Yes
106936501825.088.2844.1The acute respiratory distress syndrome. L B Ware, M A MatthayN Engl J Med200010793167No
107018241824.00.00.0The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. G S ManningQ Rev Biophys1978353876No
107118241824.00.00.0A simple fluorometric assay for lipoperoxide in blood plasma. K YagiBiochem Med1976962904Yes
107218211821.068.1668.2Physiological aspects of primary hypertension. B FolkowPhysiol Rev19826461865No
107336411820.593.6446.8Cutaneous wound healing. A J Singer, R A ClarkN Engl J Med199910471461No
107418201820.044.9244.9Animal mitochondrial genomes. J L BooreNucleic Acids Res199910101183No
107572751818.80.00.0Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. D J Sahn, A DeMaria, J Kisslo, A WeymanCirculation1978709763Yes
107636371818.575.6337.8Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Rik Derynck, Ying E ZhangNature200314534577No
107736321816.087.6543.8Brown adipose tissue: function and physiological significance. Barbara Cannon, Jan NedergaardPhysiol Rev200414715917No
107836311815.572.2136.1Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. M Karin, Y Ben-NeriahAnnu Rev Immunol200010837071No
107918151815.046.6446.6Determination and analysis of urea and guanidine hydrochloride denaturation curves. C N PaceMethods Enzymol19863773761Yes
108018151815.037.6837.7Signalling pathways of the TNF superfamily: a double-edged sword. Bharat B AggarwalNat Rev Immunol200312949498No
108118141814.049.0749.1Hepatitis B virus infection. W M LeeN Engl J Med19979392700No
1082145091813.6412.6951.6Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A ErlichScience19882448875Yes
108318111811.00.00.0A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field. D A RobinsonIEEE Trans Biomed Eng196314121113Yes
108436151807.5151.4575.7Extracellular vesicles: exosomes, microvesicles, and friends. Graça Raposo, Willem StoorvogelJ Cell Biol201323420871No
108536141807.00.00.0Polymyositis and dermatomyositis (first of two parts). A Bohan, J B PeterN Engl J Med19751090839No
108618071807.046.0646.1Cancer chemoprevention with dietary phytochemicals. Young-Joon SurhNat Rev Cancer200314570043No
108718051805.053.8253.8The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. G P ChrousosN Engl J Med19957715646No
108818031803.062.162.1Keratoconus. Y S RabinowitzSurv Ophthalmol19989493273No
108918001800.049.8149.8Mechanisms of hepatic fibrogenesis. Scott L FriedmanGastroenterology200818471545No
109017991799.00.00.0A rating instrument for anxiety disorders. W W ZungPsychosomatics19715172928Yes
109117991799.036.9937.0Systems biology: a brief overview. Hiroaki KitanoScience200211872829No
109253911797.0175.8358.6Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. C Lord, M Rutter, A Le CouteurJ Autism Dev Disord19947814313Yes
109317971797.038.9839.0Thrombin signalling and protease-activated receptors. S R CoughlinNature200011001069No
109417971797.00.00.0The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. S HestrinJ Biol Chem194918133390Yes
1095161681796.41042.45115.8Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie BrayInt J Cancer201525220842Yes
109617961796.046.7746.8Dopamine, learning and motivation. Roy A WiseNat Rev Neurosci200415152198No
109717951795.040.6140.6Theta oscillations in the hippocampus. György BuzsákiNeuron200211832222No
109835901795.094.2747.1The endophenotype concept in psychiatry: etymology and strategic intentions. Irving I Gottesman, Todd D GouldAm J Psychiatry200312668349No
109953751791.7136.5545.5Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Z N Oltvai, C L Milliman, S J KorsmeyerCell19938358790Yes
110035831791.5166.8883.4The Health Belief Model: a decade later. N K Janz, M H BeckerHealth Educ Q19846392204No
110135831791.5119.6759.8Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. Jeng-Da Chai, Martin Head-GordonPhys Chem Chem Phys200818989472Yes
110217911791.056.0556.0Hazards of heavy metal contamination. Lars JärupBr Med Bull200314757716No
110317901790.040.0440.0The immunopathogenesis of sepsis. Jonathan CohenNature200212490963No
110417891789.049.5949.6A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. P J GoodfordJ Med Chem19853892003Yes
110517891789.00.00.0A classification of hand preference by association analysis. M AnnettBr J Psychol19705457503Yes
110617891789.059.3459.3Heavy metal intensification of DAB-based HRP reaction product. J C AdamsJ Histochem Cytochem19817252134Yes
110717891789.048.0948.1Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. R D Pascual-MarquiMethods Find Exp Clin Pharmacol200212575463No
110817881788.00.00.0The measurement of volume changes in human limbs. R J WhitneyJ Physiol195313085295Yes
110917871787.059.4159.4Social cognitive theory: an agentic perspective. A BanduraAnnu Rev Psychol200111148297Yes
111035731786.5162.9481.5The Brief Symptom Inventory: an introductory report. L R Derogatis, N MelisaratosPsychol Med19836622612Yes
111153591786.3125.8241.9A new statistical method for haplotype reconstruction from population data. M Stephens, N J Smith, P DonnellyAm J Hum Genet200111254454Yes
111217851785.043.943.9The mitochondrial permeability transition pore and its role in cell death. M CromptonBiochem J199910393078No
111317841784.040.9541.0Cellular mechanisms of insulin resistance. G I ShulmanJ Clin Invest200010903330No
111417831783.060.7260.7Physiological actions of taurine. R J HuxtablePhysiol Rev19921731369No
111517821782.041.3141.3DNA topoisomerases. J C WangAnnu Rev Biochem19968811192No
111617801780.00.00.0Estimability and estimation in case-referent studies. O MiettinenAm J Epidemiol19761251836Yes
111753381779.3114.2738.1EMBOSS: the European Molecular Biology Open Software Suite. P Rice, I Longden, A BleasbyTrends Genet200010827456Yes
111817791779.00.00.0High-speed scanning in human memory. S SternbergScience19665939936Yes
111917791779.042.1542.1Global cancer statistics in the year 2000. D M ParkinLancet Oncol200111905707No
112053351778.3178.1159.4AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. P G Reeves, F H Nielsen, G C FaheyJ Nutr19938229312No
112171131778.20.00.0Antibiotic susceptibility testing by a standardized single disk method. A W Bauer, W M Kirby, J C Sherris, M TurckAm J Clin Pathol19665325707Yes
112217781778.036.9236.9DNA topoisomerases: structure, function, and mechanism. J J ChampouxAnnu Rev Biochem200111395412No
112317781778.036.7536.8Antiviral actions of interferons. C E SamuelClin Microbiol Rev200111585785No
112417771777.039.7739.8TRP channels as cellular sensors. David E ClaphamNature200314654832No
112535531776.5119.6259.8Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. R A DeFronzo, E FerranniniDiabetes Care19912044434No
112635521776.093.1146.6Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Michael T Lin, M Flint BealNature200617051205No
112735501775.00.00.0Maturation of the head of bacteriophage T4. I. DNA packaging events. U K Laemmli, M FavreJ Mol Biol19734204102Yes
112817751775.00.00.0A theory of cerebellar cortex. D MarrJ Physiol19695784296Yes
112917731773.087.9187.9Performance-oriented assessment of mobility problems in elderly patients. M E TinettiJ Am Geriatr Soc19863944402Yes
1130159561772.9358.3139.8Cytoscape: a software environment for integrated models of biomolecular interaction networks. Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey IdekerGenome Res200314597658Yes
113117721772.066.0966.1Why patients use alternative medicine: results of a national study. J A AstinJAMA19989605899Yes
113217721772.046.1646.2The hydrogen bond in the solid state. Thomas SteinerAngew Chem Int Ed Engl200212491444Yes
113335431771.5136.7768.4The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. P F Lovibond, S H LovibondBehav Res Ther19957726811Yes
113470851771.2240.1360.0Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. A J Hughes, S E Daniel, L Kilford, A J LeesJ Neurol Neurosurg Psychiatry19921564476Yes
113535421771.00.00.0Mathematical model for studying genetic variation in terms of restriction endonucleases. M Nei, W H LiProc Natl Acad Sci U S A1979291943Yes
113617711771.067.1367.1Recognition-by-components: a theory of human image understanding. Irving BiedermanPsychol Rev19873575582Yes
113717711771.052.1852.2Accurate Coulomb-fitting basis sets for H to Rn. Florian WeigendPhys Chem Chem Phys200616633586Yes
113853121770.7154.8551.6Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. F E Harrell, K L Lee, D B MarkStat Med19968668867No
113953081769.3146.8949.0Canonical sampling through velocity rescaling. Giovanni Bussi, Davide Donadio, Michele ParrinelloJ Chem Phys200717212484Yes
114017691769.00.00.0Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. U UngerstedtActa Physiol Scand Suppl19714332693Yes
114135371768.50.00.0Multiple receptors for dopamine. J W Kebabian, D B CalneNature1979215920No
114217681768.00.00.0The influence of some cations on an adenosine triphosphatase from peripheral nerves. J C SkouBiochim Biophys Acta195713412736Yes
114317681768.050.5250.5The physiology of glucagon-like peptide 1. Jens Juul HolstPhysiol Rev200717928588No
114435351767.574.637.3Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. C D Nobes, A HallCell19957536630Yes
114535331766.5124.2962.1Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. M H Zweig, G CampbellClin Chem19938472349No
114617661766.059.3559.4Sick individuals and sick populations. G RoseInt J Epidemiol19853872850Yes
114717651765.038.8738.9The complex language of chromatin regulation during transcription. Shelley L BergerNature200717522673No
114852911763.7173.9958.0The brain's default network: anatomy, function, and relevance to disease. Randy L Buckner, Jessica R Andrews-Hanna, Daniel L SchacterAnn N Y Acad Sci200818400922No
114917631763.036.7536.8Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. R J KaufmanGenes Dev199910346810No
115070461761.5175.8744.0Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. A Shevchenko, M Wilm, O Vorm, M MannAnal Chem19968779443Yes
115170391759.8280.1270.0A simple technique for quantitation of low levels of DNA damage in individual cells. N P Singh, M T McCoy, R R Tice, E L SchneiderExp Cell Res19883345800Yes
115217581758.062.0662.1The free-energy principle: a unified brain theory? Karl FristonNat Rev Neurosci201020068583No
115317571757.032.8932.9Mechanisms of alternative pre-messenger RNA splicing. Douglas L BlackAnnu Rev Biochem200312626338No
115435131756.5121.8960.9Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. G Di Chiara, A ImperatoProc Natl Acad Sci U S A19882899326Yes
115517561756.051.5851.6Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. A DunaifEndocr Rev19979408743No
115617561756.045.745.7Negative refraction makes a perfect lens PendryPhys Rev Lett200011041972Yes
115717561756.044.9244.9The global health burden of infection-associated cancers in the year 2002. Donald Maxwell ParkinInt J Cancer200616404738Yes
115817551755.048.0248.0Accurate description of van der Waals complexes by density functional theory including empirical corrections. Stefan GrimmeJ Comput Chem200415224390Yes
115917551755.045.4345.4DAMPs, PAMPs and alarmins: all we need to know about danger. Marco E BianchiJ Leukoc Biol200717032697No
116035091754.585.6142.8Protein folding in the cell. M J Gething, J SambrookNature19921731198No
116117541754.033.933.9Automated electron microscope tomography using robust prediction of specimen movements. David N MastronardeJ Struct Biol200516182563Yes
116217531753.062.162.1The role of hormone receptors and GTP-regulatory proteins in membrane transduction. M RodbellNature19806101906Yes
116317531753.044.7244.7The dawning era of polymer therapeutics. Ruth DuncanNat Rev Drug Discov200312750738No
116417521752.047.7847.8G proteins and dual control of adenylate cyclase. A G GilmanCell19846321035Yes
116517521752.037.037.0An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. R M EsnoufJ Mol Graph Model19979385560Yes
116652551751.7104.2634.8Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Jason D Fontenot, Marc A Gavin, Alexander Y RudenskyNat Immunol200312612578Yes
116717511751.045.5545.5Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Fiona TurnbullLancet200314615107Yes
116834991749.593.1346.6Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. K D McCarthy, J de VellisJ Cell Biol19806248568Yes
116969971749.2270.7167.7The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. T F Heatherton, L T Kozlowski, R C Frecker, K O FagerströmBr J Addict19911932883Yes
117017461746.00.00.0On respiratory impairment in cancer cells. O WarburgScience195613351639Yes
117117451745.039.7439.7A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. J SantaLuciaProc Natl Acad Sci U S A19989465037Yes
117234831741.50.00.0A complementation analysis of the restriction and modification of DNA in Escherichia coli. H W Boyer, D Roulland-DussoixJ Mol Biol19694896022Yes
117317411741.00.00.0A personality scale of manifest anxiety. J A TaylorJ Abnorm Psychol195313052352Yes
117417411741.058.3858.4TGFβ signalling in context. Joan MassaguéNat Rev Mol Cell Biol201222992590No
117517391739.051.251.2Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Gökhan S HotamisligilCell201020303879No
117617391739.059.9159.9Guided Search 2.0 A revised model of visual search. J M WolfePsychon Bull Rev199424203471Yes
117717381738.058.7658.8Drugs of abuse: anatomy, pharmacology and function of reward pathways. G F KoobTrends Pharmacol Sci19921604710No
117817381738.058.1958.2Health consequences of intimate partner violence. Jacquelyn C CampbellLancet200211965295No
117917351735.040.0140.0Steroid receptor regulated transcription of specific genes and gene networks. K R YamamotoAnnu Rev Genet19853909942No
118017351735.045.8445.8Interfaces and the driving force of hydrophobic assembly. David ChandlerNature200516193038No
118117321732.00.00.0Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. M J CasadabanJ Mol Biol1976781293Yes
118217321732.062.0862.1A cortical network for directed attention and unilateral neglect. M M MesulamAnn Neurol19817032417No
118317311731.081.6481.6Determinants of low birth weight: methodological assessment and meta-analysis. M S KramerBull World Health Organ19873322602No
118417311731.048.7648.8New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. R Y TsienBiochemistry19806770893Yes
118517311731.042.3742.4Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. B L WajchenbergEndocr Rev200011133069No
118617291729.044.7944.8Drug-like properties and the causes of poor solubility and poor permeability. C A LipinskiJ Pharmacol Toxicol Methods200011274893No
118751871729.0130.7743.6APE: Analyses of Phylogenetics and Evolution in R language. Emmanuel Paradis, Julien Claude, Korbinian StrimmerBioinformatics200414734327Yes
118817281728.044.7744.8The pathophysiology of tumor necrosis factors. P VassalliAnnu Rev Immunol19921590993No
118951841728.0172.4957.5Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. L Excoffier, P E Smouse, J M QuattroGenetics19921644282Yes
119034531726.566.4433.2Rho GTPases in cell biology. Sandrine Etienne-Manneville, Alan HallNature200212478284No
119117251725.042.6642.7Metabolomics--the link between genotypes and phenotypes. Oliver FiehnPlant Mol Biol200211860207No
119217241724.046.1946.2Interleukin-6: an overview. J Van SnickAnnu Rev Immunol19902188664No
119317241724.00.00.0The etiology of chondromalacia patellae. R E OuterbridgeJ Bone Joint Surg Br196114038135Yes
119417231723.046.5646.6A theory of cortical responses. Karl FristonPhilos Trans R Soc Lond B Biol Sci200515937014No
119551681722.7113.4337.8Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. A Nicholls, K A Sharp, B HonigProteins19911758883Yes
119617221722.062.4862.5Cyclosporine. B D KahanN Engl J Med19892687689No
119717221722.039.239.2The synaptic vesicle cycle: a cascade of protein-protein interactions. T C SüdhofNature19957791897No
119817211721.054.9154.9An overview of brominated flame retardants in the environment. Cynthia A de WitChemosphere200211999784No
119934401720.093.3346.7Prediction of protein antigenic determinants from amino acid sequences. T P Hopp, K R WoodsProc Natl Acad Sci U S A19816167991Yes
120017201720.056.3856.4Calculation of substrate oxidation rates in vivo from gaseous exchange. K N FraynJ Appl Physiol Respir Environ Exerc Physiol19836618956Yes
120151571719.01725.64575.2Cancer statistics, 2020. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin202031912902Yes
120234351717.588.6344.3The biology of vascular endothelial growth factor. N Ferrara, T Davis-SmythEndocr Rev19979034784No
120317171717.032.7832.8CD4+ CD25+ suppressor T cells: more questions than answers. Ethan M ShevachNat Rev Immunol200212093005No
120417161716.00.00.0Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. J N DumontJ Morphol19724109871Yes
120517161716.00.00.0ATPase activity of myosin correlated with speed of muscle shortening. M BárányJ Gen Physiol19674227924Yes
120617151715.072.5972.6The Resonating Valence Bond State in La2CuO4 and Superconductivity. P W AndersonScience198717818979Yes
120717141714.067.6167.6Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. H U WittchenJ Psychiatr Res19948064641No
120834251712.576.2438.1Cell death: critical control points. Nika N Danial, Stanley J KorsmeyerCell200414744432No
120917121712.00.00.0The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. R RossJ Cell Biol19714327464Yes
121051351711.7232.0877.4Some statistical methods useful in circulation research. S Wallenstein, C L Zucker, J L FleissCirc Res19807379260Yes
121117101710.00.00.0Dynamic properties of mammalian skeletal muscles. R I ClosePhysiol Rev19724256989No
121217101710.038.0938.1Developmental regulation of the growth plate. Henry M KronenbergNature200312748651No
121317091709.00.00.0The statistical analysis of enzyme kinetic data. W W ClelandAdv Enzymol Relat Areas Mol Biol19674881884No
121451271709.0135.245.1Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. G S Hotamisligil, N S Shargill, B M SpiegelmanScience19937678183Yes
121517091709.040.4740.5Neutrophils and immunity: challenges and opportunities. Carl NathanNat Rev Immunol200616498448No
121617091709.043.3943.4Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Jeffrey A EngelmanNat Rev Cancer200919629070No
121717081708.00.00.0Comparison of the predicted and observed secondary structure of T4 phage lysozyme. B W MatthewsBiochim Biophys Acta19751180967Yes
121834151707.50.00.0The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. A E Bolton, W M HunterBiochem J19734733239Yes
121917071707.048.448.4The extracellular matrix: not just pretty fibrils. Richard O HynesScience200919965464No
122068271706.8133.3333.3Transformation of intact yeast cells treated with alkali cations. H Ito, Y Fukuda, K Murata, A KimuraJ Bacteriol19836336730Yes
122117061706.093.0493.0The assessment of clinical skills/competence/performance. G E MillerAcad Med19902400509Yes
122217061706.00.00.0Positional information and the spatial pattern of cellular differentiation. L WolpertJ Theor Biol19694390734Yes
122351081702.7169.0356.3Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. R L Spitzer, K Kroenke, J B WilliamsJAMA199910568646Yes
122417021702.033.533.5Approaching the asymptote? Evolution and revolution in immunology. C A JanewayCold Spring Harb Symp Quant Biol19892700931No
122517021702.036.4636.5Structure and regulation of voltage-gated Ca2+ channels. W A CatterallAnnu Rev Cell Dev Biol200011031246No
1226187121701.1414.9437.7Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P MesirovProc Natl Acad Sci U S A200516199517Yes
122717001700.034.7534.8Notch signalling: a simple pathway becomes complex. Sarah J BrayNat Rev Mol Cell Biol200616921404No
1228118941699.1276.1639.5Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank SpelemanGenome Biol200212184808Yes
122933971698.586.6343.3Measuring the thickness of the human cerebral cortex from magnetic resonance images. B Fischl, A M DaleProc Natl Acad Sci U S A200010984517Yes
123067941698.5147.0536.8WebLogo: a sequence logo generator. Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E BrennerGenome Res200415173120Yes
123133961698.090.4345.2Cloned glutamate receptors. M Hollmann, S HeinemannAnnu Rev Neurosci19948210177No
123216971697.00.00.0Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. E M WitkinBacteriol Rev1976795416No
123316961696.00.00.0Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. M Wong-RileyBrain Res1979223730Yes
123416961696.0100.25100.2Determination and quantification of content validity. M R LynnNurs Res19863640358Yes
123516961696.00.00.0Protein denaturation. C TanfordAdv Protein Chem19684882248No
123616961696.00.00.0A graphic method for the determination and presentation of binding parameters in a complex system. H E RosenthalAnal Biochem19676048188Yes
123716951695.054.5254.5Glutamate: a neurotransmitter in mammalian brain. F FonnumJ Neurochem19846139418No
123833881694.093.4546.7Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. K B Mullis, F A FaloonaMethods Enzymol19873431465Yes
123916931693.00.00.0Method for the determination of hexosamines in tissues. N F BoasJ Biol Chem195313117829Yes
124016931693.046.2146.2Follicular helper CD4 T cells (TFH). Shane CrottyAnnu Rev Immunol201121314428No
124116921692.057.0657.1Epidemiological features of chronic low-back pain. G B AnderssonLancet199910470716No
124216911691.043.1443.1Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. D LavanchyJ Viral Hepat200414996343No
124333811690.5157.7778.9Multiwfn: a multifunctional wavefunction analyzer. Tian Lu, Feiwu ChenJ Comput Chem201222162017Yes
124433791689.586.2143.1Matrix metalloproteinases. H Nagase, J F WoessnerJ Biol Chem199910419448No
124516891689.045.7945.8Integrins. E RuoslahtiJ Clin Invest19911985087No
124616891689.044.4944.5Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. G C WalkerMicrobiol Rev19846371470No
124733761688.00.00.0A "Direct-Coloring" Thiocholine Method For Cholinesterases. M J Karnovsky, L RootsJ Histochem Cytochem196414187330Yes
124816871687.00.00.0Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. A F HabeebAnal Biochem19664161471Yes
124933731686.572.0736.0Identification of common molecular subsequences. T F Smith, M S WatermanJ Mol Biol19817265238Yes
125016861686.031.7131.7How eukaryotic transcriptional activators work. M PtashneNature19883050531No
125116861686.057.8457.8Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. C E MogensenN Engl J Med19846690964Yes
125216851685.056.5756.6Pineal melatonin: cell biology of its synthesis and of its physiological interactions. R J ReiterEndocr Rev19911649044No
125316851685.063.3863.4Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. D R JaneroFree Radic Biol Med19902079232No
125416851685.057.9858.0Large-scale neurocognitive networks and distributed processing for attention, language, and memory. M M MesulamAnn Neurol19902260847No
125550531684.3204.1568.0featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Yang Liao, Gordon K Smyth, Wei ShiBioinformatics201424227677Yes
125616841684.054.0154.0Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. M ZasloffProc Natl Acad Sci U S A19873299384Yes
125716841684.053.6353.6Social determinants of health inequalities. Michael MarmotLancet200515781105Yes
125816821682.040.6540.6The molecular genetics of cancer. J M BishopScience19873541204No
125916821682.035.5935.6MicroRNA biogenesis: coordinated cropping and dicing. V Narry KimNat Rev Mol Cell Biol200515852042No
126016821682.041.8841.9Integrating cell-signalling pathways with NF-kappaB and IKK function. Neil D PerkinsNat Rev Mol Cell Biol200717183360No
126150441681.3251.283.7HISAT: a fast spliced aligner with low memory requirements. Daehwan Kim, Ben Langmead, Steven L SalzbergNat Methods201525751142Yes
126216811681.00.00.0Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. A KrishanJ Cell Biol197549354Yes
126316811681.00.00.0An improved procedure for serum creatine phosphokinase determination. S B RosalkiJ Lab Clin Med19674381359Yes
126416811681.036.4136.4Molecular regulation of vessel maturation. Rakesh K JainNat Med200312778167No
126550391679.799.9233.3Surfing the p53 network. B Vogelstein, D Lane, A J LevineNature200011099028No
126616791679.00.00.0Why genes in pieces? W GilbertNature1978622185Yes
126716791679.00.00.0The theory and applications of the exchange of inert gas at the lungs and tissues. S S KetyPharmacol Rev195114833874Yes
126816781678.036.3336.3Mechanisms of cancer drug resistance. Michael M GottesmanAnnu Rev Med200211818492No
126916781678.00.00.0Plastic Embedding Mixtures For Use In Electron Microscopy. H H MollenhauerStain Technol196414127791Yes
1270167711677.1532.953.3Measurement of protein using bicinchoninic acid. P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C KlenkAnal Biochem19853843705Yes
127116771677.00.00.0Dendritic organization in the neurons of the visual and motor cortices of the cat. D A ShollJ Anat195313117757Yes
127233521676.00.00.0The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties. T Omura, R SatoJ Biol Chem196414209972Yes
127316751675.00.00.0Transplacental carcinogenesis by stilbestrol. J FolkmanN Engl J Med19715556579Yes
127433471673.594.2547.1Biochemistry of multidrug resistance mediated by the multidrug transporter. M M Gottesman, I PastanAnnu Rev Biochem19938102521No
127533461673.00.00.0Receptive fields and functional architecture of monkey striate cortex. D H Hubel, T N WieselJ Physiol19684966457Yes
127616731673.044.7644.8Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Scott L FriedmanPhysiol Rev200818195085No
127716721672.037.8937.9The distribution of secondary growths in cancer of the breast. 1889. S PagetCancer Metastasis Rev19892673568No
127816721672.040.740.7Evolutionary relationship of DNA sequences in finite populations. F TajimaGenetics19836628982Yes
127916721672.040.7540.8Type III protein secretion systems in bacterial pathogens of animals and plants. C J HueckMicrobiol Mol Biol Rev19989618447No
128016711671.00.00.0Drugs which inhibit prostaglandin biosynthesis. R J FlowerPharmacol Rev19744208101Yes
128116711671.00.00.0Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. J A MillerCancer Res19704915745No
128216701670.00.00.0The general adaptation syndrome and the diseases of adaptation. H SelyeJ Clin Endocrinol Metab194621025115Yes
128366761669.00.00.0Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. E A Jaffe, R L Nachman, C G Becker, C R MinickJ Clin Invest19734355998Yes
128416691669.00.00.0Evolutionary rate at the molecular level. M KimuraNature19685637732Yes
1285116811668.7294.6242.1Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya YamanakaCell200718035408Yes
128616681668.060.9460.9Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). G G GlennerN Engl J Med19806154243No
128749951665.0115.6738.6Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Michael W Pfaffl, Graham W Horgan, Leo DempfleNucleic Acids Res200211972351Yes
128883201664.0232.9446.6Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary KingDiabetes Care200415111519Yes
128916631663.058.0558.0Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. A H ConneyCancer Res19826814745No
129016631663.00.00.0Chromatographic Separation Of Human Brain Gangliosides. L SvennerholmJ Neurochem196314066623Yes
129116621662.070.170.1Perception of risk. P SlovicScience19873563507Yes
129233221661.0148.0674.0The MOS social support survey. C D Sherbourne, A L StewartSoc Sci Med19912035047Yes
129333211660.50.00.0Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. M Grunstein, D S HognessProc Natl Acad Sci U S A19751105573Yes
129416591659.00.00.0Areas, volumes, packing and protein structure. F M RichardsAnnu Rev Biophys Bioeng1977326146No
129516591659.056.2256.2The crisis in antibiotic resistance. H C NeuScience19921509257No
129633171658.50.00.0Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. J Marmur, P DotyJ Mol Biol196214470099Yes
129716581658.067.7867.8Predicting basal metabolic rate, new standards and review of previous work. W N SchofieldHum Nutr Clin Nutr19854044297Yes
129816581658.058.0958.1Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? B HalliwellLancet19947915779No
129916571657.039.2439.2Solvent-accessible surfaces of proteins and nucleic acids. M L ConnollyScience19836879170Yes
130016571657.00.00.0Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate. J SpizizenProc Natl Acad Sci U S A195816590310Yes
130116551655.00.00.0Mode of cell migration to the superficial layers of fetal monkey neocortex. P RakicJ Comp Neurol19724624784Yes
130233091654.594.6947.3Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. Kresse, HafnerPhys Rev B Condens Matter199410010505Yes
130316541654.034.4434.4Structural features in eukaryotic mRNAs that modulate the initiation of translation. M KozakJ Biol Chem19911939050No
130416541654.038.6238.6The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. D M KingsleyGenes Dev19948299934No
130516531653.056.0856.1Serum albumin. T PetersAdv Protein Chem19853904348No
130633061653.072.1836.1Integrin signaling. F G Giancotti, E RuoslahtiScience199910446041No
130716511651.00.00.0Carbonic anhydrase: chemistry, physiology, and inhibition. T H MarenPhysiol Rev19674964060No
130816511651.047.7547.8Biofilms: microbial life on surfaces. Rodney M DonlanEmerg Infect Dis200212194761No
130966021650.5236.2559.1A brief measure for assessing generalized anxiety disorder: the GAD-7. Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd LöweArch Intern Med200616717171Yes
131016481648.048.8548.9Flavonoids as antioxidants. P G PiettaJ Nat Prod200010924197No
131116481648.039.5539.5Fabrication of novel biomaterials through molecular self-assembly. Shuguang ZhangNat Biotechnol200314520402No
131216481648.035.2535.2DNA methylation and human disease. Keith D RobertsonNat Rev Genet200516136652No
131332941647.085.6242.8Receptors for purines and pyrimidines. V Ralevic, G BurnstockPharmacol Rev19989755289No
131416471647.036.9336.9Exploring complex networks. S H StrogatzNature200111258382No
131516441644.00.00.0Pedigrees of some mutant strains of Escherichia coli K-12. B J BachmannBacteriol Rev19724568763No
131616441644.00.00.0A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. D MattinglyJ Clin Pathol196214471419Yes
131765751643.8153.0138.3Use of T7 RNA polymerase to direct expression of cloned genes. F W Studier, A H Rosenberg, J J Dunn, J W DubendorffMethods Enzymol19902199796Yes
131816411641.037.3437.3Effects of cytochalasin and phalloidin on actin. J A CooperJ Cell Biol19873312229No
131916411641.044.4344.4What is cognitive reserve? Theory and research application of the reserve concept. Yaakov SternJ Int Neuropsychol Soc200211939702No
132032811640.5109.154.5Role of free radicals and catalytic metal ions in human disease: an overview. B Halliwell, J M GutteridgeMethods Enzymol19902172697No
132116401640.034.1834.2Cancer and the chemokine network. Fran BalkwillNat Rev Cancer200415229479No
132232801640.0130.8465.4The biofilm matrix. Hans-Curt Flemming, Jost WingenderNat Rev Microbiol201020676145No
132332741637.00.00.0Method for the isolation of intact islets of Langerhans from the rat pancreas. P E Lacy, M KostianovskyDiabetes19675333500Yes
132432741637.0143.8171.9A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. J G Snodgrass, M VanderwartJ Exp Psychol Hum Learn19807373248Yes
132516371637.051.9752.0The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. B L FredricksonAm Psychol200111315248Yes
132616361636.045.5245.5Turnover of inositol phospholipids and signal transduction. Y NishizukaScience19846147898No
132732681634.079.1839.6The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. P Angel, M KarinBiochim Biophys Acta19911751545No
132816341634.044.2644.3Dengue and dengue hemorrhagic fever. D J GublerClin Microbiol Rev19989665979No
132916341634.069.1169.1Doxil®--the first FDA-approved nano-drug: lessons learned. Yechezkel BarenholzJ Control Release201222484195No
133016331633.075.9776.0Role of nrf2 in oxidative stress and toxicity. Qiang MaAnnu Rev Pharmacol Toxicol201323294312No
1331114231631.9422.1160.3Assessing the quality of reports of randomized clinical trials: is blinding necessary? A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuayControl Clin Trials19968721797Yes
133232631631.575.8237.9Amino acid substitution matrices from protein blocks. S Henikoff, J G HenikoffProc Natl Acad Sci U S A19921438297Yes
133316311631.051.351.3Inhibited spontaneous emission in solid-state physics and electronics. YablonovitchPhys Rev Lett198710034639Yes
133416311631.034.9134.9The effect of infections on susceptibility to autoimmune and allergic diseases. Jean-Francois BachN Engl J Med200212239261No
133516301630.052.4552.5Metallothionein. D H HamerAnnu Rev Biochem19863527054No
133616301630.045.6245.6Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. H LeVineProtein Sci19938453378Yes
133716301630.046.5946.6Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. Robert E MarxJ Oral Maxillofac Surg200312966493Yes
133832531626.580.9640.5Liver fibrosis. Ramón Bataller, David A BrennerJ Clin Invest200515690074No
133916261626.038.7438.7NADPH oxidase: an update. B M BabiorBlood199910029572No
134016261626.049.5949.6Intestinal mucosal barrier function in health and disease. Jerrold R TurnerNat Rev Immunol200919855405No
134132511625.586.1743.1Quantum dot bioconjugates for ultrasensitive nonisotopic detection. W C Chan, S NieScience19989748158Yes
134216251625.048.6648.7Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. E M WassermannElectroencephalogr Clin Neurophysiol19989474057No
134332501625.0105.5352.8Efficient pseudopotentials for plane-wave calculations. Troullier, MartinsPhys Rev B Condens Matter19919997467Yes
134432501625.091.1645.6Protein structure prediction on the Web: a case study using the Phyre server. Lawrence A Kelley, Michael J E SternbergNat Protoc200919247286Yes
1345162371623.7522.4252.2The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S LuthraArthritis Rheum19883358796Yes
134632451622.574.0337.0Monocyte and macrophage heterogeneity. Siamon Gordon, Philip R TaylorNat Rev Immunol200516322748No
134716221622.00.00.0The micronucleus test. W SchmidMutat Res197548190Yes
134816221622.036.3236.3Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. S L FriedmanJ Biol Chem200010644669No
134916221622.060.5660.6Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Sergio PecorelliInt J Gynaecol Obstet200919367689No
135016211621.058.6158.6Cell damage in the brain: a speculative synthesis. B K SiesjöJ Cereb Blood Flow Metab19816276420No
135116211621.00.00.0Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. E G GrayJ Anat195913829103Yes
135232411620.571.5535.8Protein structure comparison by alignment of distance matrices. L Holm, C SanderJ Mol Biol19938377180Yes
135348601620.0156.3852.1Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. H Esterbauer, R J Schaur, H ZollnerFree Radic Biol Med19911937131No
135464771619.2133.5833.4Stem cells, cancer, and cancer stem cells. T Reya, S J Morrison, M F Clarke, I L WeissmanNature200111689955No
135516191619.00.00.0RNA-dependent DNA polymerase in virions of RNA tumour viruses. D BaltimoreNature19704316300Yes
135616191619.040.1140.1Inflammatory bowel disease: etiology and pathogenesis. C FiocchiGastroenterology19989649475No
135716191619.031.7331.7Cellular roles of DNA topoisomerases: a molecular perspective. James C WangNat Rev Mol Cell Biol200212042765No
135832361618.087.9144.0Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering Nie, EmoryScience19979027306Yes
135916161616.049.0749.1Extracellular ATP: effects, sources and fate. J L GordonBiochem J19863006665No
136016161616.032.0632.1Hox genes in vertebrate development. R KrumlaufCell19947913880No
136116161616.032.3832.4Cell cycle checkpoints: preventing an identity crisis. S J ElledgeScience19968939848No
136232281614.0101.6250.8Nonparametric statistical testing of EEG- and MEG-data. Eric Maris, Robert OostenveldJ Neurosci Methods200717517438Yes
136332271613.5100.5450.3Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. F Denizot, R LangJ Immunol Methods19863486233Yes
136432271613.5110.3855.2Wnt/β-catenin signaling and disease. Hans Clevers, Roel NusseCell201222682243No
136564531613.2161.4840.4Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. C A Lipinski, F Lombardo, B W Dominy, P J FeeneyAdv Drug Deliv Rev200111259830No
136616131613.082.5482.5Microplastics in the marine environment. Anthony L AndradyMar Pollut Bull201121742351No
136716121612.051.4651.5The atom economy--a search for synthetic efficiency. B M TrostScience19911962206Yes
136816121612.070.6270.6Neurogenetic adaptive mechanisms in alcoholism. C R CloningerScience19872882604Yes
136916121612.041.9642.0Neurotrophins and neuronal plasticity. H ThoenenScience19957570017No
137016111611.037.0337.0Cellular oncogenes and retroviruses. J M BishopAnnu Rev Biochem19836351725No
137116111611.044.8744.9Oxidative stress hypothesis in Alzheimer's disease. W R MarkesberyFree Radic Biol Med19979165306No
137216101610.041.1241.1Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Paul M RidkerCirculation200312551853No
137316101610.045.645.6The comet assay for DNA damage and repair: principles, applications, and limitations. Andrew R CollinsMol Biotechnol200415004294No
137432181609.00.00.0New method for quantitative determination of uronic acids. N Blumenkrantz, G Asboe-HansenAnal Biochem19734269305Yes
137564301607.5176.9644.2Epithelial-mesenchymal transitions in development and disease. Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela NietoCell200919945376No
137616071607.050.8250.8Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. D W ChoiTrends Neurosci19882469166No
137732141607.079.5239.8PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. Alexander W Schüttelkopf, Daan M F van AaltenActa Crystallogr D Biol Crystallogr200415272157Yes
137864271606.8269.7967.4Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanJ Clin Epidemiol200919631508No
137932121606.00.00.0A fluorometric method for determination of oxidized and reduced glutathione in tissues. P J Hissin, R HilfAnal Biochem1976962076Yes
138016061606.067.3667.4Negative symptoms in schizophrenia. Definition and reliability. N C AndreasenArch Gen Psychiatry19827165477Yes
138116061606.044.7944.8Chlorpromazine equivalent doses for the newer atypical antipsychotics. Scott W WoodsJ Clin Psychiatry200312823080No
138232101605.095.9348.0The inflammasomes. Kate Schroder, Jurg TschoppCell201020303873No
138316041604.046.2646.3Cell biology and molecular basis of denitrification. W G ZumftMicrobiol Mol Biol Rev19979409151No
138416041604.041.0241.0Episodic memory: from mind to brain. Endel TulvingAnnu Rev Psychol200211752477Yes
138516041604.052.1152.1PsychoPy--Psychophysics software in Python. Jonathan W PeirceJ Neurosci Methods200717254636Yes
138616041604.054.9855.0Global epidemiology of oral and oropharyngeal cancer. Saman WarnakulasuriyaOral Oncol200918804401No
138796231603.8277.4646.2Positional cloning of the mouse obese gene and its human homologue. Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M FriedmanNature19947984236Yes
138816031603.00.00.0Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. O OuchterlonyActa Pathol Microbiol Scand195313079779Yes
138932041602.0126.9863.5Assays of glutathione peroxidase. L Flohé, W A GünzlerMethods Enzymol19846727659Yes
139032041602.085.3942.7Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Christian Haass, Dennis J SelkoeNat Rev Mol Cell Biol200717245412No
139116011601.047.1947.2Metalloproteinases and their inhibitors in matrix remodeling. L M MatrisianTrends Genet19902132731No
139216011601.029.9329.9Maximum-likelihood density modification. T C TerwilligerActa Crystallogr D Biol Crystallogr200010944333Yes
139316001600.044.8944.9An index to quantify an individual's scientific research output. J E HirschProc Natl Acad Sci U S A200516275915Yes
139431981599.077.0338.5Rapid and sensitive protein similarity searches. D J Lipman, W R PearsonScience19852983426Yes
139515991599.048.8448.8MYC on the path to cancer. Chi V DangCell201222464321No
139615981598.050.4550.5A measure of population subdivision based on microsatellite allele frequencies. M SlatkinGenetics19957705646Yes
139715971597.035.2435.2Bone morphogenetic proteins: multifunctional regulators of vertebrate development. B L HoganGenes Dev19968682290No
139815961596.036.9436.9VLA proteins in the integrin family: structures, functions, and their role on leukocytes. M E HemlerAnnu Rev Immunol19902188667No
139915961596.030.3330.3Cyclin-dependent kinases: engines, clocks, and microprocessors. D O MorganAnnu Rev Cell Dev Biol19979442875No
140031921596.075.537.8Parkinson's disease: mechanisms and models. William Dauer, Serge PrzedborskiNeuron200312971891No
140131921596.089.3844.7Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. Steven E Nissen, Kathy WolskiN Engl J Med200717517853Yes
140231901595.063.8831.9Automated MAD and MIR structure solution. T C Terwilliger, J BerendzenActa Crystallogr D Biol Crystallogr199910089316Yes
140315941594.00.00.0Chromatin structure: a repeating unit of histones and DNA. R D KornbergScience19744825889Yes
140431871593.563.331.6Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. M E Greenberg, E B ZiffNature19846090941Yes
140579591591.8210.5142.1Mapping and quantifying mammalian transcriptomes by RNA-Seq. Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara WoldNat Methods200818516045Yes
140647701590.0163.3954.5FastTree 2--approximately maximum-likelihood trees for large alignments. Morgan N Price, Paramvir S Dehal, Adam P ArkinPLoS One201020224823Yes
140715881588.031.7431.7An analysis of vertebrate mRNA sequences: intimations of translational control. M KozakJ Cell Biol19911955461No
140863471586.8262.1465.5Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg LangBehav Res Methods200919897823Yes
140931721586.00.00.0Variations in the pattern of pubertal changes in boys. W A Marshall, J M TannerArch Dis Child19705440182Yes
141031701585.00.00.0Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. M Mihara, M UchiyamaAnal Biochem1978655387Yes
141115841584.057.8257.8Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. P HolzerPharmacol Rev19911852779No
141215841584.00.00.0The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. A G PearseJ Histochem Cytochem19694143745No
141331681584.089.5644.8The mirror-neuron system. Giacomo Rizzolatti, Laila CraigheroAnnu Rev Neurosci200415217330No
141431671583.5113.2156.6Avoiding false positives with PCR. S Kwok, R HiguchiNature19892716852Yes
141515831583.039.9540.0Tumor necrosis factor (TNF). L J OldScience19852413547Yes
141615821582.048.0648.1Classification of inflammatory bowel disease. J E Lennard-JonesScand J Gastroenterol Suppl19892617184Yes
141715821582.00.00.0Structural considerations in the interaction of DNA and acridines. L S LermanJ Mol Biol196113761054Yes
141815821582.043.3343.3The genetics of ageing. Cynthia J KenyonNature201020336132No
141915811581.034.6334.6The caveolae membrane system. R G AndersonAnnu Rev Biochem19989759488No
142015801580.00.00.0Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. K O FagerströmAddict Behav1978735910Yes
142115801580.037.7837.8Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. S A BustinJ Mol Endocrinol200212200227No
142215791579.042.8642.9Using circular dichroism spectra to estimate protein secondary structure. Norma J GreenfieldNat Protoc200617406547Yes
142315791579.055.7455.7Grounded cognition. Lawrence W BarsalouAnnu Rev Psychol200817705682No
142415781578.045.5545.5Ionic dependence of glutamate neurotoxicity. D W ChoiJ Neurosci19872880938Yes
142515781578.033.0333.0The synaptic vesicle cycle. Thomas C SudhofAnnu Rev Neurosci200415217342No
142615771577.00.00.0Interhemispheric differences in the localization of psychological processes in man. B MilnerBr Med Bull19714937273No
142731541577.078.1639.1CAP3: A DNA sequence assembly program. X Huang, A MadanGenome Res199910508846Yes
142831541577.090.9245.5Biofilms: survival mechanisms of clinically relevant microorganisms. Rodney M Donlan, J William CostertonClin Microbiol Rev200211932229No
142931521576.078.0839.0A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. S Tabor, C C RichardsonProc Natl Acad Sci U S A19853156376Yes
143031521576.068.1734.1Inhibitors of mammalian G1 cyclin-dependent kinases. C J Sherr, J M RobertsGenes Dev19957758941No
143115761576.044.2944.3Network pharmacology: the next paradigm in drug discovery. Andrew L HopkinsNat Chem Biol200818936753No
143231491574.591.4445.7ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. B Ravel, M NewvilleJ Synchrotron Radiat200515968136Yes
143315741574.00.00.0Computerized transverse axial scanning (tomography). 1. Description of system. G N HounsfieldBr J Radiol19734757352Yes
143415741574.053.2353.2Number of people with glaucoma worldwide. H A QuigleyBr J Ophthalmol19968695555No
143515731573.040.7740.8Angiogenesis: an organizing principle for drug discovery? Judah FolkmanNat Rev Drug Discov200717396134No
143647161572.0113.3337.8Inflammation and atherosclerosis. Peter Libby, Paul M Ridker, Attilio MaseriCirculation200211877368No
1437109941570.6285.6240.8Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M NathanN Engl J Med200211832527Yes
143815701570.052.3652.4Biology of interleukin 1. C A DinarelloFASEB J19883277884No
143931401570.088.544.2Polyamines. C W Tabor, H TaborAnnu Rev Biochem19846206782No
144015681568.041.341.3Alpha-crystallin can function as a molecular chaperone. J HorwitzProc Natl Acad Sci U S A19921438232Yes
144131361568.00.00.0A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues. G Schmidt, S J ThannhauserJ Biol Chem194521005717Yes
144215661566.00.00.0Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. B HilleJ Gen Physiol1977300786Yes
144315661566.046.1946.2Perceptual symbol systems. L W BarsalouBehav Brain Sci199911301525No
144415661566.00.00.0The estimation of phosphorus. R J AllenBiochem J194016747230Yes
144515651565.00.00.0Regulation of noradrenaline release by presynaptic receptor systems. K StarkeRev Physiol Biochem Pharmacol197714389No
144646951565.0103.9434.6Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. J E Darnell, I M Kerr, G R StarkScience19948197455No
144715651565.034.5834.6Excitatory actions of gaba during development: the nature of the nurture. Yehezkel Ben-AriNat Rev Neurosci200212209121No
144831291564.597.5948.8Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. D S Bredt, S H SnyderProc Natl Acad Sci U S A19901689048Yes
144915631563.034.1934.2On finding all suboptimal foldings of an RNA molecule. M ZukerScience19892468181No
145015631563.00.00.0A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin. B C HummelCan J Biochem Physiol195914405350Yes
145131251562.591.4345.7Building better batteries. M Armand, J-M TarasconNature200818256660No
145215611561.00.00.0Fluorescence energy transfer as a spectroscopic ruler. L StryerAnnu Rev Biochem1978354506No
145315611561.071.9371.9Mood and memory. G H BowerAm Psychol19817224324Yes
145415601560.00.00.0Paced auditory serial-addition task: a measure of recovery from concussion. D M GronwallPercept Mot Skills1977866038Yes
145531201560.063.2731.6SIFT: Predicting amino acid changes that affect protein function. Pauline C Ng, Steven HenikoffNucleic Acids Res200312824425Yes
145615591559.055.3155.3Frontal-subcortical circuits and human behavior. J L CummingsArch Neurol19938352676No
145731181559.069.4434.7Insulin signalling and the regulation of glucose and lipid metabolism. A R Saltiel, C R KahnNature200111742412Yes
145815581558.042.9743.0The complete general secretory pathway in gram-negative bacteria. A P PugsleyMicrobiol Rev19938096622No
145915581558.035.9135.9The proto-oncogene Bcl-2 and its role in regulating apoptosis. G KroemerNat Med19979176486No
146015581558.053.6653.7Hypoxia-inducible factors in physiology and medicine. Gregg L SemenzaCell201222304911No
146131151557.5141.0770.5miRBase: annotating high confidence microRNAs using deep sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201424275495Yes
146215571557.061.7261.7Modeling and variable selection in epidemiologic analysis. S GreenlandAm J Public Health19892916724Yes
146315571557.00.00.0Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. W H OldendorfAm J Physiol19715124307Yes
146415561556.048.5448.5Infrared spectroscopy of proteins. Andreas BarthBiochim Biophys Acta200717692815No
146562231555.8169.9342.5Cancer-related inflammation. Alberto Mantovani, Paola Allavena, Antonio Sica, Frances BalkwillNature200818650914No
146615551555.033.3333.3Points of control in inflammation. Carl NathanNature200212490957No
146746641554.7133.1944.4Cell death: the significance of apoptosis. A H Wyllie, J F Kerr, A R CurrieInt Rev Cytol19807014501No
146831081554.00.00.0Convergent and discriminant validation by the multitrait-multimethod matrix. D T Campbell, D W FiskePsychol Bull195913634291Yes
146915541554.039.8239.8Tumor angiogenesis. Robert S KerbelN Engl J Med200818463380No
147046601553.3144.9448.3Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. P A Wolf, R D Abbott, W B KannelStroke19911866765Yes
147131041552.094.1547.1Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. M Karas, F HillenkampAnal Chem19883239801Yes
147215511551.041.6941.7Adipose tissue, adipokines, and inflammation. Giamila FantuzziJ Allergy Clin Immunol200515867843No
147346521550.7189.1163.0The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. C A McHorney, J E Ware, A E RaczekMed Care19938450681Yes
147415501550.00.00.0The relationship between the spleen colony-forming cell and the haemopoietic stem cell. R SchofieldBlood Cells1978747780Yes
147515501550.029.6529.6Germinal centers. I C MacLennanAnnu Rev Immunol19948011279No
147615501550.031.4531.4Generating samples under a Wright-Fisher neutral model of genetic variation. Richard R HudsonBioinformatics200211847089Yes
147715501550.032.6132.6Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Judith CampisiCell200515734683No
147815491549.052.5752.6Archaea in coastal marine environments. E F DeLongProc Natl Acad Sci U S A19921608980Yes
147915491549.045.1845.2Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. S HakomoriAnnu Rev Biochem19817023369No
148046461548.70.00.0A highly sensitive adenylate cyclase assay. Y Salomon, C Londos, M RodbellAnal Biochem19744827395Yes
148115481548.041.9542.0Molecular bases of the acute coronary syndromes. P LibbyCirculation19957758192No
148215481548.051.4251.4Health consequences of obesity in youth: childhood predictors of adult disease. W H DietzPediatrics199812224658No
148315481548.034.334.3Protein homology detection by HMM-HMM comparison. Johannes SödingBioinformatics200515531603Yes
148446431547.7101.6633.9A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. Zhang, Chung, OldenburgJ Biomol Screen199910838414Yes
148530931546.5206.83103.4A clinical method of functional assessment of the shoulder. C R Constant, A H MurleyClin Orthop Relat Res19873791738Yes
148615451545.040.1740.2Molecular biology of prion diseases. S B PrusinerScience19911675487No
148715451545.045.3945.4The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. R R LlinásScience19883059497No
148815451545.060.3660.4Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. P HolzerNeuroscience19883288903No
148946331544.3104.9835.0An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J K Eng, A L McCormack, J R YatesJ Am Soc Mass Spectrom199424226387Yes
149015441544.043.9844.0Leptospirosis. P N LevettClin Microbiol Rev200111292640No
149130861543.065.6232.8A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. D Wessel, U I FlüggeAnal Biochem19846731838Yes
149215431543.037.2337.2Recognition of microorganisms and activation of the immune response. Ruslan MedzhitovNature200717943118No
149315421542.060.4560.5Simple proton spectroscopic imaging. W T DixonRadiology19846089263Yes
149415421542.038.1938.2HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. J M CoffinScience19957824947Yes
149515421542.049.9249.9Cellular defenses against damage from reactive oxygen species. B P YuPhysiol Rev19948295932No
149615421542.048.8548.9Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. F RoussetGenetics19979093870Yes
149715411541.051.5851.6Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). M N MarshGastroenterology19921727768No
149815411541.00.00.0Discharge patterns and functional organization of mammalian retina. S W KufflerJ Neurophysiol195313035466Yes
149915401540.034.1434.1Neuronal calcium signaling. M J BerridgeNeuron19989697848No
150015401540.044.1744.2Oxidative stress and neurodegeneration: where are we now? Barry HalliwellJ Neurochem200616805774No
150115401540.061.3561.4Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. Lutz AckermannChem Rev201121391562Yes
150230791539.590.6245.3Oxidative stress, glutamate, and neurodegenerative disorders. J T Coyle, P PuttfarckenScience19937901908No
150346181539.3131.7543.9The metabolic syndrome--a new worldwide definition. K George M M Alberti, Paul Zimmet, Jonathan ShawLancet200516182882Yes
150415391539.00.00.0Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. H S PenefskyJ Biol Chem197716006Yes
150515381538.030.3630.4Switching and signaling at the telomere. E H BlackburnCell200111572773No
150646111537.0103.4834.5Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. M A Frohman, M K Dush, G R MartinProc Natl Acad Sci U S A19882461560Yes
150730741537.0122.4161.2The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. A J Stunkard, S MessickJ Psychosom Res19853981480Yes
150815371537.066.6366.6The drug abuse screening test. H A SkinnerAddict Behav19827183189Yes
150915351535.034.7634.8Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. C TaswellJ Immunol19817009746Yes
151015351535.050.1750.2The stress response in fish. S E Wendelaar BongaPhysiol Rev19979234959No
151115351535.041.941.9From sensation to cognition. M M MesulamBrain19989648540No
151215341534.00.00.0Antigen-Antibody Crossed Electrophoresis. C B LaurellAnal Biochem196514302464Yes
151315331533.044.5744.6Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. A E PeggCancer Res19883123052No
151430651532.5104.352.1Understanding interobserver agreement: the kappa statistic. Anthony J Viera, Joanne M GarrettFam Med200515883903Yes
151530631531.576.6238.3Neuronal oscillations in cortical networks. György Buzsáki, Andreas DraguhnScience200415218136No
151645921530.70.00.0Impact of Event Scale: a measure of subjective stress. M Horowitz, N Wilner, W AlvarezPsychosom Med1979472086Yes
151745911530.3118.2139.4Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. Earl S Ford, Wayne H Giles, William H DietzJAMA200211790215Yes
151830581529.00.00.0The structure of coping. L I Pearlin, C SchoolerJ Health Soc Behav1978649936Yes
151915291529.038.9839.0Early signals in the mitogenic response. E RozengurtScience19863018928No
152015291529.039.3339.3Cellular basis of working memory. P S Goldman-RakicNeuron19957695894No
152115291529.027.4927.5Cell cycle checkpoint signaling through the ATM and ATR kinases. R T AbrahamGenes Dev200111544175No
152215291529.045.7445.7Introduction and General Overview of Cyclodextrin Chemistry. József SzejtliChem Rev199811848947Yes
152330581529.094.1647.1The unfolded protein response: from stress pathway to homeostatic regulation. Peter Walter, David RonScience201122116877No
152430571528.572.8836.4Issues and challenges facing rechargeable lithium batteries. J M Tarascon, M ArmandNature200111713543Yes
152515271527.00.00.0An enzymic method for the trace iodination of immunoglobulins and other proteins. J J MarchalonisBiochem J19694185494Yes
152630521526.00.00.0Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. C B Lozzio, B B LozzioBlood1975163658Yes
152715261526.036.6636.7AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. D Grahame HardieNat Rev Mol Cell Biol200717712357No
152830511525.50.00.0New Giemsa method for the differential staining of sister chromatids. P Perry, S WolffNature19744138930Yes
152930511525.589.4644.7Event-related EEG/MEG synchronization and desynchronization: basic principles. G Pfurtscheller, F H Lopes da SilvaClin Neurophysiol199910576479No
153015251525.030.6230.6E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. J R NevinsScience19921411535Yes
153115251525.034.2734.3Molecular themes in oncogenesis. J M BishopCell19911988146No
153215251525.045.445.4Recent advances in the biochemistry of polyamines in eukaryotes. A E PeggBiochem J19863087344No
153391491524.8216.936.1Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuireScience19873798106Yes
153430491524.5103.7851.9The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. R Doll, R PetoJ Natl Cancer Inst19817017215No
153530441522.071.8335.9The epigenomics of cancer. Peter A Jones, Stephen B BaylinCell200717320506No
153615211521.046.146.1Multiple imputation: a primer. J L SchaferStat Methods Med Res199910347857No
153715201520.039.2239.2Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. M J MeaneyAnnu Rev Neurosci200111520931No
153815191519.041.5941.6Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. L A LiottaCancer Res19862998604No
153915191519.070.3570.3The contribution of low birth weight to infant mortality and childhood morbidity. M C McCormickN Engl J Med19853880598No
154015191519.040.8440.8Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. D A DoughertyScience19968539615No
154115191519.00.00.0Dithiothreitol, A New Protective Reagent For Sh Groups. W W ClelandBiochemistry196414192894Yes
154215191519.049.3749.4Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? George A BonannoAm Psychol200414736317No
154315161516.070.7970.8Measurement of health state utilities for economic appraisal. G W TorranceJ Health Econ198610311607No
154415151515.00.00.0Which elements are excited in electrical stimulation of mammalian central nervous system: a review. J B RanckBrain Res19751102064No
154515151515.038.2138.2Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. Z YangJ Mol Evol19947932792Yes
154615151515.044.5244.5The in vitro micronucleus technique. M FenechMutat Res200011113469No
154715141514.00.00.0Calcium release from the sarcoplasmic reticulum. M EndoPhysiol Rev197713441Yes
154815141514.027.6227.6Altering the genome by homologous recombination. M R CapecchiScience19892660260No
154930261513.083.7741.9Angiogenesis. J Folkman, Y ShingJ Biol Chem19921375931No
155090781513.0192.8132.1Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C MelloNature19989486653Yes
155115131513.038.1338.1The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Michael R LieberAnnu Rev Biochem201020192759No
155290601510.0314.552.4Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R TannenbaumAnal Biochem19827181105Yes
155330191509.5111.1255.6ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. M Gardes, T D BrunsMol Ecol19938180733Yes
155415091509.036.436.4Getting formal with dopamine and reward. Wolfram SchultzNeuron200212383780No
155515071507.080.380.3Conservation of resources. A new attempt at conceptualizing stress. S E HobfollAm Psychol19892648906No
155630131506.50.00.0Computed circular dichroism spectra for the evaluation of protein conformation. N Greenfield, G D FasmanBiochemistry19695346390Yes
155730131506.560.2230.1Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. O Tetsu, F McCormickNature199910201372Yes
155830121506.0100.5650.3Separate visual pathways for perception and action. M A Goodale, A D MilnerTrends Neurosci19921374953No
155930121506.00.00.0Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. D B Dill, D L CostillJ Appl Physiol19744850854Yes
156015041504.00.00.0Biological applications of ionophores. B C PressmanAnnu Rev Biochem1976786156No
156115041504.029.0529.1How cells read TGF-beta signals. J MassaguéNat Rev Mol Cell Biol200011252892No
156215041504.043.3143.3Determination of minimum inhibitory concentrations. J M AndrewsJ Antimicrob Chemother200111420333Yes
156330081504.064.1332.1Upstream and downstream of mTOR. Nissim Hay, Nahum SonenbergGenes Dev200415314020No
156415031503.00.00.0Some observations upon a new inhibitor of monoamine oxidase in brain tissue. J P JohnstonBiochem Pharmacol19685659776Yes
156515031503.056.8556.9Aging, natural death, and the compression of morbidity. J F FriesN Engl J Med19807383070Yes
156630061503.080.4140.2Origins and Mechanisms of miRNAs and siRNAs. Richard W Carthew, Erik J SontheimerCell200919239886No
156715001500.059.4759.5Probiotics in man and animals. R FullerJ Appl Bacteriol19892666378No
156815001500.037.8637.9Trophic factors and neuronal survival. Y A BardeNeuron19892697237No
156915001500.042.1642.2Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Y Ben-AriNeuroscience19852859548No
157015001500.043.743.7Oxidative stress: oxidants and antioxidants. H SiesExp Physiol19979129943No
157114991499.066.5766.6A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. D J SchuirmannJ Pharmacokinet Biopharm19873450848Yes
157214981498.036.0336.0Trastuzumab--mechanism of action and use in clinical practice. Clifford A HudisN Engl J Med200717611206No
157314961496.044.2544.2The basal ganglia: focused selection and inhibition of competing motor programs. J W MinkProg Neurobiol19969004351No
1574119681496.0319.2139.9Electric field effect in atomically thin carbon films. K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A FirsovScience200415499015Yes
157514961496.044.9945.0Porous scaffold design for tissue engineering. Scott J HollisterNat Mater200516003400No
157659811495.20.00.0The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. S P Baker, B O'Neill, W Haddon, W B LongJ Trauma19744814394Yes
157714951495.030.630.6The ubiquitin-proteasome proteolytic pathway. A CiechanoverCell19947923371No
157814941494.047.447.4The role of the amygdala in fear and anxiety. M DavisAnnu Rev Neurosci19921575447No
157914941494.030.0530.1Neuroblastoma: biological insights into a clinical enigma. Garrett M BrodeurNat Rev Cancer200312612655No
158029881494.065.2832.6Signaling to NF-kappaB. Matthew S Hayden, Sankar GhoshGenes Dev200415371334No
158114931493.041.0541.0THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. Kozi AsadaAnnu Rev Plant Physiol Plant Mol Biol199915012221Yes
158214931493.041.7441.7P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation. Berk HessJ Chem Theory Comput200826619985Yes
158329851492.582.8541.4A scaling normalization method for differential expression analysis of RNA-seq data. Mark D Robinson, Alicia OshlackGenome Biol201020196867Yes
158414921492.00.00.0The inverse care law. J T HartLancet19714100731Yes
158514921492.00.00.0Dopamine (3-hydroxytyramine) and brain function. O HornykiewiczPharmacol Rev19665328389No
158614921492.037.3637.4Python: a programming language for software integration and development. M F SannerJ Mol Graph Model199910660911Yes
158714911491.039.3939.4The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. A S FauciScience19883277274No
158844731491.0121.6140.5Median-joining networks for inferring intraspecific phylogenies. H J Bandelt, P Forster, A RöhlMol Biol Evol199910331250Yes
158914911491.036.5436.5Thiazolidinediones. Hannele Yki-JärvinenN Engl J Med200415356308No
159029811490.574.1837.1Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Robert Visse, Hideaki NagaseCirc Res200312730128No
159129801490.0156.9678.5Interrater reliability of a modified Ashworth scale of muscle spasticity. R W Bohannon, M B SmithPhys Ther19873809245Yes
159259571489.2232.2558.1SignalP 4.0: discriminating signal peptides from transmembrane regions. Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik NielsenNat Methods201121959131Yes
159314891489.00.00.0Synaptic density in human frontal cortex - developmental changes and effects of aging. P R HuttenlocherBrain Res1979427544Yes
159414891489.031.0631.1Network motifs: theory and experimental approaches. Uri AlonNat Rev Genet200717510665No
159514881488.056.0656.1The linear-quadratic formula and progress in fractionated radiotherapy. J F FowlerBr J Radiol19892670032No
159614881488.033.5333.5Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. G L SemenzaAnnu Rev Cell Dev Biol199910611972No
159714871487.00.00.0Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J C UnkelessJ Exp Med197990108Yes
159814871487.00.00.0Bias in analytic research. D L SackettJ Chronic Dis1979447779Yes
159914871487.035.4435.4Hypertrophic cardiomyopathy: a systematic review. Barry J MaronJAMA200211886323No
160014871487.037.0637.1The retinal pigment epithelium in visual function. Olaf StraussPhysiol Rev200515987797No
160174331486.6198.3939.7Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan HsuN Engl J Med200415385656Yes
160229731486.50.00.0Lactic dehydrogenase activity in blood. F Wroblewski, J S LadueProc Soc Exp Biol Med195513273400Yes
160314861486.052.3652.4Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Leonardo PantoniLancet Neurol201020610345No
160414851485.00.00.0Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. S AvrameasImmunochemistry19694975324Yes
160514851485.030.3830.4The microRNA Registry. Sam Griffiths-JonesNucleic Acids Res200414681370Yes
160644491483.095.1231.7The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. S K Hanks, A M Quinn, T HunterScience19883291115No
160714831483.00.00.0A soluble protein characteristic of the nervous system. B W MooreBiochem Biophys Res Commun19654953930Yes
160814821482.038.1938.2The corticosteroid receptor hypothesis of depression. F HolsboerNeuropsychopharmacology200011027914No
160914811481.00.00.0Simple methods for "staining with lead" at high pH in electron microscopy. M J KarnovskyJ Biophys Biochem Cytol196114454024Yes
161029621481.066.9733.5Why do cancers have high aerobic glycolysis? Robert A Gatenby, Robert J GilliesNat Rev Cancer200415516961No
161114811481.046.2446.2Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Ralph A DefronzoDiabetes200919336687No
161229601480.0107.954.0Macrophage plasticity and polarization: in vivo veritas. Antonio Sica, Alberto MantovaniJ Clin Invest201222378047No
161388771479.5279.4946.6Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939837Yes
161414791479.052.052.0Lyme disease. A C SteereN Engl J Med19892668764No
161514791479.038.538.5Growth of the plant cell wall. Daniel J CosgroveNat Rev Mol Cell Biol200516261190No
161644351478.389.6829.9Efficient selection for high-expression transfectants with a novel eukaryotic vector. H Niwa, K Yamamura, J MiyazakiGene19911660837Yes
161714781478.00.00.0The colorimetric determination of phosphorus. E J KingBiochem J193216744823Yes
161829551477.575.7337.9The BCL-2 protein family: opposing activities that mediate cell death. Richard J Youle, Andreas StrasserNat Rev Mol Cell Biol200818097445No
161914771477.033.6633.7Tumor suppressor genes. R A WeinbergScience19911659741No
162014771477.039.9840.0Rheumatoid arthritis. Pathophysiology and implications for therapy. E D HarrisN Engl J Med19902271017No
162129531476.50.00.0The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. E G Gray, V P WhittakerJ Anat196213901297Yes
162259051476.2289.3972.3jModelTest 2: more models, new heuristics and parallel computing. Diego Darriba, Guillermo L Taboada, Ramón Doallo, David PosadaNat Methods201222847109Yes
162314761476.036.4836.5Recognition of errors in three-dimensional structures of proteins. M J SipplProteins19938108378Yes
162414761476.044.1844.2Molecular dissection of reactive astrogliosis and glial scar formation. Michael V SofroniewTrends Neurosci200919782411No
162514751475.00.00.0Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. C S NeerJ Bone Joint Surg Am19725054450Yes
162614751475.00.00.0The recurrence of intracranial meningiomas after surgical treatment. D SimpsonJ Neurol Neurosurg Psychiatry195713406590Yes
162729461473.058.9429.5Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. P J Mitchell, R TjianScience19892667136No
162814721472.036.5336.5A revolution in optical manipulation. David G GrierNature200312917694No
162914721472.043.8843.9Trail Making Test A and B: normative data stratified by age and education. Tom N TombaughArch Clin Neuropsychol200415010086Yes
163014721472.044.0144.0What we can do and what we cannot do with fMRI. Nikos K LogothetisNature200818548064No
163129431471.572.736.4Human mesenchymal stem cells modulate allogeneic immune cell responses. Sudeepta Aggarwal, Mark F PittengerBlood200515494428Yes
163214711471.00.00.0Isolated removal of hypothalamic or other brain nuclei of the rat. M PalkovitsBrain Res19734747772Yes
163314711471.050.1950.2A new automated colorimetric method for measuring total oxidant status. Ozcan ErelClin Biochem200516214125Yes
163414701470.00.00.0Simple memory: a theory for archicortex. D MarrPhilos Trans R Soc Lond B Biol Sci19714399412Yes
163514701470.041.3141.3Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. A FabiatoAm J Physiol19836346892No
163614701470.00.00.0Application of a Theory of Enzyme Specificity to Protein Synthesis. D E KoshlandProc Natl Acad Sci U S A195816590179Yes
163729391469.569.0134.5Fibroblasts in cancer. Raghu Kalluri, Michael ZeisbergNat Rev Cancer200616572188No
163829391469.573.5836.8The DNA-damage response in human biology and disease. Stephen P Jackson, Jiri BartekNature200919847258No
163929371468.5114.5257.3Microenvironmental regulation of tumor progression and metastasis. Daniela F Quail, Johanna A JoyceNat Med201324202395No
164014671467.00.00.0Atherogenesis: a postprandial phenomenon. D B ZilversmitCirculation1979222498Yes
164144011467.0180.8160.3Effect of the damping function in dispersion corrected density functional theory. Stefan Grimme, Stephan Ehrlich, Lars GoerigkJ Comput Chem201121370243Yes
164243981466.0153.6651.2A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. J R Le Gall, S Lemeshow, F SaulnierJAMA19938254858Yes
164329311465.562.0731.0Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Gary L Johnson, Razvan LapadatScience200212471242No
164429291464.50.00.0Junctional complexes in various epithelia. M G Farquhar, G E PaladeJ Cell Biol196313944428Yes
164514641464.00.00.0Cerebral blood flow and oxygen consumption in man. N A LassenPhysiol Rev195913645234Yes
164629281464.00.00.0A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. A H Anton, D F SayreJ Pharmacol Exp Ther196214013351Yes
164729271463.50.00.0A general method for isolation of high molecular weight DNA from eukaryotes. N Blin, D W StaffordNucleic Acids Res1976987581Yes
164814631463.049.2549.2Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. H J GundersenJ Microsc19863761363Yes
164914621462.035.5635.6Introduction to NF-kappaB: players, pathways, perspectives. T D GilmoreOncogene200617072321No
165029231461.592.2846.1Autophagy: renovation of cells and tissues. Noboru Mizushima, Masaaki KomatsuCell201122078875No
165114611461.039.1239.1Precision mapping of quantitative trait loci. Z B ZengGenetics19948013918Yes
165243801460.00.00.0The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. J T Dodge, C Mitchell, D J HanahanArch Biochem Biophys196314028302Yes
165314601460.046.246.2Gold-catalyzed organic reactions. A Stephen K HashmiChem Rev200717580975Yes
165414591459.033.633.6Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. M B LuskinNeuron19938338665Yes
165514591459.00.00.0Cognitive maps in rats and men. E C TolmanPsychol Rev194818870876Yes
165643771459.0116.5638.9Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Prateek Kumar, Steven Henikoff, Pauline C NgNat Protoc200919561590Yes
165714581458.025.3125.3Neuronal specification in the spinal cord: inductive signals and transcriptional codes. T M JessellNat Rev Genet200011262869No
165829141457.065.7632.9Cell migration: a physically integrated molecular process. D A Lauffenburger, A F HorwitzCell19968608589No
1659160271457.0437.639.8PLINK: a tool set for whole-genome association and population-based linkage analyses. Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C ShamAm J Hum Genet200717701901Yes
166072801456.0167.8333.6Stages of embryonic development of the zebrafish. C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F SchillingDev Dyn19958589427Yes
166114561456.031.7331.7DNA in a material world. Nadrian C SeemanNature200312540916No
166243671455.789.0129.7T-Coffee: A novel method for fast and accurate multiple sequence alignment. C Notredame, D G Higgins, J HeringaJ Mol Biol200010964570Yes
166372771455.4184.536.9Development and testing of a general amber force field. Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A CaseJ Comput Chem200415116359Yes
166458191454.80.00.0A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. M A Markwell, S M Haas, L L Bieber, N E TolbertAnal Biochem197898070Yes
166529091454.568.4934.2Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. C Auffray, F RougeonEur J Biochem19806772444Yes
166643631454.3150.6150.2Phylogenetic identification and in situ detection of individual microbial cells without cultivation. R I Amann, W Ludwig, K H SchleiferMicrobiol Rev19957535888No
166743631454.384.1828.1Notch signaling: cell fate control and signal integration in development. S Artavanis-Tsakonas, M D Rand, R J LakeScience199910221902No
166814541454.00.00.0Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections. R W SperryProc Natl Acad Sci U S A196314077501Yes
166914541454.037.9938.0Tricine-SDS-PAGE. Hermann SchäggerNat Protoc200617406207Yes
167014531453.00.00.0Selforganization of matter and the evolution of biological macromolecules. M EigenNaturwissenschaften19714942363No
167158091452.2289.0472.3The Satisfaction With Life Scale. E Diener, R A Emmons, R J Larsen, S GriffinJ Pers Assess198516367493Yes
167214521452.040.7340.7Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. J A BeavoPhysiol Rev19957480160No
167314521452.00.00.0Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues. I E BushBiochem J195214915960Yes
167414521452.035.6535.6The hippo signaling pathway in development and cancer. Duojia PanDev Cell201020951342No
167514511451.039.3239.3Redox signaling: nitrosylation and related target interactions of nitric oxide. J S StamlerCell19947923362No
167614511451.00.00.0Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. P C NowellCancer Res196014427849Yes
167714511451.034.7834.8Perceptions of epigenetics. Adrian BirdNature200717522671Yes
167814501450.046.5646.6Constructions of masculinity and their influence on men's well-being: a theory of gender and health. W H CourtenaySoc Sci Med200010741575No
167914501450.031.5531.6Oxidative stress shortens telomeres. Thomas von ZglinickiTrends Biochem Sci200212114022Yes
168014501450.035.8335.8Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). K M FoxLancet200313678872Yes
168143471449.00.00.0Hydroperoxide metabolism in mammalian organs. B Chance, H Sies, A BoverisPhysiol Rev197937532Yes
168214491449.00.00.0Ionic blockage of sodium channels in nerve. A M WoodhullJ Gen Physiol19734541078Yes
168314491449.00.00.0Starch gel electrophoresis in a discontinous system of buffers. M D PoulikNature195713493570Yes
168414481448.00.00.0The organization of proteins in the human red blood cell membrane. A review. T L SteckJ Cell Biol19744600883No
168514481448.00.00.0Defective repair replication of DNA in xeroderma pigmentosum. J E CleaverNature19685655953Yes
168614481448.034.8134.8A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. D A GewirtzBiochem Pharmacol199910075079No
168714481448.028.9729.0Intrinsically unstructured proteins. Peter TompaTrends Biochem Sci200212368089No
168828951447.50.00.0Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. D H Clarke, J CasalsAm J Trop Med Hyg195813571577Yes
168986851447.5288.6948.1Cancer statistics, 2009. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J ThunCA Cancer J Clin200919474385Yes
169014471447.00.00.0The mechanism of muscular contraction. H E HuxleyScience19694181952No
169143411447.0118.239.4A neural substrate of prediction and reward. W Schultz, P Dayan, P R MontagueScience19979054347No
169214471447.031.331.3Neurotrophins and their receptors: a convergence point for many signalling pathways. Moses V ChaoNat Rev Neurosci200312671646No
169372351447.00.00.0Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function. S Katz, A B Ford, R W Moskowitz, B A Jackson, M W JaffeJAMA196314044222Yes
169414471447.00.00.0The free amino groups of insulin. F SangerBiochem J194516747948Yes
169528941447.095.3847.7Alzheimer's disease. Henry W Querfurth, Frank M LaFerlaN Engl J Med201020107219No
169614451445.031.6231.6Drug discovery: a historical perspective. J DrewsScience200010720314No
169728891444.50.00.0Diabetes and cardiovascular disease. The Framingham study. W B Kannel, D L McGeeJAMA1979430798Yes
169857781444.50.00.0The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. L A Sternberger, P H Hardy, J J Cuculis, H G MeyerJ Histochem Cytochem19704192899Yes
169914441444.048.4848.5Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. G A McPhersonJ Pharmacol Methods19853840547Yes
170028881444.083.3941.7Diarrheagenic Escherichia coli. J P Nataro, J B KaperClin Microbiol Rev19989457432No
170114441444.032.0332.0From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. W A CatterallNeuron200010798388No
170228881444.072.3936.2Shared principles in NF-kappaB signaling. Matthew S Hayden, Sankar GhoshCell200818267068No
170328871443.566.8833.4Complex networks orchestrate epithelial-mesenchymal transitions. Jean Paul Thiery, Jonathan P SleemanNat Rev Mol Cell Biol200616493418No
170428871443.598.5349.3Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Stephen M Smith, Thomas E NicholsNeuroimage200918501637Yes
170514421442.00.00.0Impulses and Physiological States in Theoretical Models of Nerve Membrane. R FitzhughBiophys J196119431309Yes
170628831441.579.9740.0A rapid boiling method for the preparation of bacterial plasmids. D S Holmes, M QuigleyAnal Biochem19816269464Yes
170728831441.576.6738.3The expanding universe of T-cell subsets: Th1, Th2 and more. T R Mosmann, S SadImmunol Today19968820272No
170814411441.046.1546.1Evidence for a central component of post-injury pain hypersensitivity. C J WoolfNature19836656869Yes
170914401440.028.9729.0Protein kinases--the major drug targets of the twenty-first century? Philip CohenNat Rev Drug Discov200212120282No
171028791439.5105.7352.9Palladium-catalyzed ligand-directed C-H functionalization reactions. Thomas W Lyons, Melanie S SanfordChem Rev201020078038No
171114391439.00.00.0Superoxide dismutases. I FridovichAnnu Rev Biochem19751094908No
171214391439.042.8542.9Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. M D MainesFASEB J19883290025No
171314391439.00.00.0Nutrition needs of mammalian cells in tissue culture. H EagleScience195513255879Yes
171428771438.50.00.03' non-coding region sequences in eukaryotic messenger RNA. N J Proudfoot, G G BrownleeNature1976822353Yes
171528771438.597.3948.7Molecular mechanisms and clinical applications of angiogenesis. Peter Carmeliet, Rakesh K JainNature201121593862No
171614381438.00.00.0Stimulated acoustic emissions from within the human auditory system. D T KempJ Acoust Soc Am1978744838Yes
171714381438.041.9942.0Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. P A BradfordClin Microbiol Rev200111585791No
171814381438.037.6737.7Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Shitij KapurAm J Psychiatry200312505794No
171928721436.00.00.0Assay of proteins in the presence of interfering materials. A Bensadoun, D WeinsteinAnal Biochem19761259145Yes
172028721436.00.00.0Mutants of Escherichia coli requiring methionine or vitamin B12. B D Davis, E S MingioliJ Bacteriol195015436457Yes
172128701435.059.5929.8NF-kappaB regulation in the immune system. Qiutang Li, Inder M VermaNat Rev Immunol200212360211No
172214341434.037.6337.6Capacitative calcium entry revisited. J W PutneyCell Calcium19901965707No
172343021434.0120.5140.2Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. M Hasegawa, H Kishino, T YanoJ Mol Evol19853934395Yes
172414341434.00.00.0Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle. H E HuxleyJ Mol Biol196314064165Yes
172528671433.5110.2155.1Shifting the genomic gold standard for the prokaryotic species definition. Michael Richter, Ramon Rosselló-MóraProc Natl Acad Sci U S A200919855009Yes
1726143331433.3357.2935.7Multilineage potential of adult human mesenchymal stem cells. M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R MarshakScience199910102814Yes
172714331433.034.1334.1Binary Agrobacterium vectors for plant transformation. M BevanNucleic Acids Res19846095209Yes
172828651432.574.837.4Empirical threshold values for quantitative trait mapping. G A Churchill, R W DoergeGenetics19947851788Yes
172914321432.037.1837.2Type I diabetes mellitus. A chronic autoimmune disease. G S EisenbarthN Engl J Med19863517648No
173014311431.028.928.9Protein degradation and protection against misfolded or damaged proteins. Alfred L GoldbergNature200314685250No
173157231430.8234.1958.516S ribosomal DNA amplification for phylogenetic study. W G Weisburg, S M Barns, D A Pelletier, D J LaneJ Bacteriol19911987160Yes
173228591429.5111.8455.9The mini-mental state examination: a comprehensive review. T N Tombaugh, N J McIntyreJ Am Geriatr Soc19921512391No
1733128531428.1402.2744.7The 1982 revised criteria for the classification of systemic lupus erythematosus. E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J WinchesterArthritis Rheum19827138600Yes
173414281428.00.00.0Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. J W OlneyScience19695778021Yes
173528561428.055.727.9The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Michael H Glickman, Aaron CiechanoverPhysiol Rev200211917093No
173628551427.561.0230.5Toll-like receptor control of the adaptive immune responses. Akiko Iwasaki, Ruslan MedzhitovNat Immunol200415454922No
173742791426.3111.9637.3The rapid generation of mutation data matrices from protein sequences. D T Jones, W R Taylor, J M ThorntonComput Appl Biosci19921633570Yes
173814261426.032.5232.5An approximately unbiased test of phylogenetic tree selection. Hidetoshi ShimodairaSyst Biol200212079646Yes
173914251425.025.8625.9Histone acetylation and transcriptional regulatory mechanisms. K StruhlGenes Dev19989499396No
174028501425.057.1328.6Missing pieces in the NF-kappaB puzzle. Sankar Ghosh, Michael KarinCell200211983155No
174114241424.00.00.0A clinical method for assessing the ventilatory response to carbon dioxide. D J ReadAustralas Ann Med19676032026Yes
174214241424.045.5445.5Polycystic ovary syndrome. S FranksN Engl J Med19957651477No
174328471423.5105.3852.7The transtheoretical model of health behavior change. J O Prochaska, W F VelicerAm J Health Promot199710170434No
174456931423.2118.7229.7A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. B M Bolstad, R A Irizarry, M Astrand, T P SpeedBioinformatics200312538238Yes
174514231423.029.4529.4Immunosuppressive networks in the tumour environment and their therapeutic relevance. Weiping ZouNat Rev Cancer200515776005No
174614221422.00.00.0Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. M P BlausteinAm J Physiol1977324293No
174714221422.032.8132.8The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. M TakeichiDevelopment19883048970No
174814221422.00.00.0A modified ninhydrin colorimetric analysis for amino acids. H RosenArch Biochem Biophys195713412116Yes
174914211421.033.6533.6Developmental cell death: morphological diversity and multiple mechanisms. P G ClarkeAnat Embryol (Berl)19902186664No
175014201420.033.8833.9Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. S C ManolagasEndocr Rev200010782361No
175128391419.555.5827.8Cellular motility driven by assembly and disassembly of actin filaments. Thomas D Pollard, Gary G BorisyCell200312600310No
175214191419.051.4451.4Dual-task interference in simple tasks: data and theory. H PashlerPsychol Bull19947972591No
175314191419.035.435.4In vivo near-infrared fluorescence imaging. John V FrangioniCurr Opin Chem Biol200314580568No
175428361418.082.9441.5Dali server: conservation mapping in 3D. Liisa Holm, Päivi RosenströmNucleic Acids Res201020457744Yes
175528341417.054.1527.1Mutations affecting segment number and polarity in Drosophila. C Nüsslein-Volhard, E WieschausNature19806776413Yes
175628341417.072.3236.2Adipose tissue as an endocrine organ. Erin E Kershaw, Jeffrey S FlierJ Clin Endocrinol Metab200415181022No
175714151415.033.5233.5Pathogenesis of group A streptococcal infections. M W CunninghamClin Microbiol Rev200010885988No
175828291414.567.9434.0The human plasma proteome: history, character, and diagnostic prospects. N Leigh Anderson, Norman G AndersonMol Cell Proteomics200212488461No
175942431414.3106.0835.4Two-photon laser scanning fluorescence microscopy. W Denk, J H Strickler, W W WebbScience19902321027Yes
176014141414.035.2335.2General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. R A HoughtenProc Natl Acad Sci U S A19852410914Yes
176114141414.00.00.0The Gingival Index, the Plaque Index and the Retention Index Systems. H LöeJ Periodontol19675237684Yes
176214141414.033.5533.5PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. Michael F. ThomashowAnnu Rev Plant Physiol Plant Mol Biol199915012220Yes
176328281414.063.7431.9Raster3D Version 2.0. A program for photorealistic molecular graphics. E A Merritt, M E MurphyActa Crystallogr D Biol Crystallogr199415299354Yes
176414141414.00.00.0Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions. W C SchneiderJ Biol Chem194818886166Yes
176528271413.569.0134.5The incidence of congenital heart disease. Julien I E Hoffman, Samuel KaplanJ Am Coll Cardiol200212084585No
176614131413.00.00.0Amino acid difference formula to help explain protein evolution. R GranthamScience19744843792Yes
176714131413.00.00.0Modality and topographic properties of single neurons of cat's somatic sensory cortex. V B MountcastleJ Neurophysiol195713439410Yes
176828261413.00.00.0Microdetermination of long-chain fatty acids in plasma and tissues. V P Dole, H MeinertzJ Biol Chem196013817286Yes
176942391413.00.00.0Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. C A Winter, E A Risley, G W NussProc Soc Exp Biol Med196214001233Yes
177028251412.575.2937.6Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. M A Nitsche, W PaulusJ Physiol200010990547Yes
177114121412.045.8945.9The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. G R BuettnerArch Biochem Biophys19938434935No
177228231411.562.531.2Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. E Krissinel, K HenrickActa Crystallogr D Biol Crystallogr200415572779Yes
177314111411.034.034.0PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. B M SpiegelmanDiabetes19989568680No
177414111411.027.2527.2Aggresomes, inclusion bodies and protein aggregation. R R KopitoTrends Cell Biol200011121744No
177528221411.059.8629.9The Bcl2 family: regulators of the cellular life-or-death switch. Suzanne Cory, Jerry M AdamsNat Rev Cancer200212209154No
177614111411.036.7436.7The biology of incretin hormones. Daniel J DruckerCell Metab200616517403No
177728191409.561.7130.9The Ki-67 protein: from the known and the unknown. T Scholzen, J GerdesJ Cell Physiol200010653597No
177814091409.030.1830.2Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. R K JainNat Med200111533692No
177914071407.00.00.0The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases. O V BatsonAnn Surg194017857618Yes
178028141407.081.7140.9Multiple sclerosis. Alastair Compston, Alasdair ColesLancet200818970977Yes
178128131406.559.1729.6Chemokines: a new classification system and their role in immunity. A Zlotnik, O YoshieImmunity200010714678No
178228111405.584.3342.2The precuneus: a review of its functional anatomy and behavioural correlates. Andrea E Cavanna, Michael R TrimbleBrain200616399806No
178314051405.077.5177.5Subjective well-being. E DienerPsychol Bull19846399758No
178414051405.028.6328.6Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. D I SvergunBiophys J199910354416Yes
178514051405.032.7932.8Mechanisms of bone metastasis. G David RoodmanN Engl J Med200415084698No
178614051405.030.1130.1Regulatory T cells, tumour immunity and immunotherapy. Weiping ZouNat Rev Immunol200616557261No
178728061403.066.5633.3The MAPK signaling cascade. R Seger, E G KrebsFASEB J19957601337No
178828041402.065.9233.0A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. L Buck, R AxelCell19911840504Yes
178914011401.058.9959.0Responses to depression and their effects on the duration of depressive episodes. S Nolen-HoeksemaJ Abnorm Psychol19911757671No
179056021400.5143.7435.9Improved optimization for the robust and accurate linear registration and motion correction of brain images. Mark Jenkinson, Peter Bannister, Michael Brady, Stephen SmithNeuroimage200212377157Yes
179114001400.036.0836.1Insulin and insulin-like growth factor signalling in neoplasia. Michael PollakNat Rev Cancer200819029956No
179214001400.051.5451.5Cognitive reserve. Yaakov SternNeuropsychologia200919467352No
179313991399.051.8951.9The case-crossover design: a method for studying transient effects on the risk of acute events. M MaclureAm J Epidemiol19911985444Yes
179413991399.061.4561.5Antibiotics in the aquatic environment--a review--part I. Klaus KümmererChemosphere200919185900No
179513971397.044.0144.0Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. L BravoNutr Rev19989838798No
179627921396.083.7741.9An information-maximization approach to blind separation and blind deconvolution. A J Bell, T J SejnowskiNeural Comput19957584893Yes
179727921396.00.00.0Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. H J Bloom, W W RichardsonBr J Cancer195713499785Yes
179813961396.034.5134.5Neurovascular regulation in the normal brain and in Alzheimer's disease. Costantino IadecolaNat Rev Neurosci200415100718No
179941871395.792.8631.0NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. S Ghosh, M J May, E B KoppAnnu Rev Immunol19989597130No
180013951395.065.2765.3The structure and properties of the sense of coherence scale. A AntonovskySoc Sci Med19938480217Yes
180127901395.065.0932.5How matrix metalloproteinases regulate cell behavior. M D Sternlicht, Z WerbAnnu Rev Cell Dev Biol200111687497No
180213951395.00.00.0Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look. J WymanAdv Protein Chem196414268785No
180327881394.00.00.0Empirical predictions of protein conformation. P Y Chou, G D FasmanAnnu Rev Biochem1978354496No
180413941394.055.7755.8Large-scale brain networks and psychopathology: a unifying triple network model. Vinod MenonTrends Cogn Sci201121908230No
180513941394.056.7956.8Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. Virginia A MoyerAnn Intern Med201222801674No
180613931393.00.00.0Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. K S McCullyAm J Pathol19695792556Yes
180755721393.0126.731.7MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi MiyataNucleic Acids Res200212136088Yes
180869611392.2147.429.5Prospective identification of tumorigenic breast cancer cells. Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F ClarkeProc Natl Acad Sci U S A200312629218Yes
180927831391.585.3942.7The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. J D Hayes, D J PulfordCrit Rev Biochem Mol Biol19958770536No
181027821391.085.9143.0Intracellular pH. A Roos, W F BoronPhysiol Rev19817012859No
181155641391.0164.9241.2Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. B Biswal, F Z Yetkin, V M Haughton, J S HydeMagn Reson Med19958524021Yes
181213911391.050.1750.2Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Joseph J VolpeLancet Neurol200919081519No
181313911391.072.7272.7Statistics corner: A guide to appropriate use of correlation coefficient in medical research. M M MukakaMalawi Med J201223638278Yes
181455611390.2242.8660.7An inventory for measuring clinical anxiety: psychometric properties. A T Beck, N Epstein, G Brown, R A SteerJ Consult Clin Psychol19883204199Yes
181527801390.072.9636.5Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. I Issemann, S GreenNature19902129546Yes
181613901390.00.00.0R factor transfer in Rhizobium leguminosarum. J E BeringerJ Gen Microbiol19744612098Yes
181713901390.039.2539.2Pathogen recognition and inflammatory signaling in innate immune defenses. Trine H MogensenClin Microbiol Rev200919366914No
181813891389.050.9651.0Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Berislav V ZlokovicNat Rev Neurosci201122048062No
181955521388.00.00.0A rating scale for mania: reliability, validity and sensitivity. R C Young, J T Biggs, V E Ziegler, D A MeyerBr J Psychiatry1978728692Yes
182027741387.00.00.0A method of trace iodination of proteins for immunologic studies. P J McConahey, F J DixonInt Arch Allergy Appl Immunol19664160044Yes
182127741387.085.7342.9Unified approach for molecular dynamics and density-functional theory. Car, ParrinelloPhys Rev Lett198510032153Yes
182213871387.036.336.3Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. B Winkel-ShirleyPlant Physiol200111402179No
182327741387.00.00.0Brain stem reticular formation and activation of the EEG. G Moruzzi, H W MagounElectroencephalogr Clin Neurophysiol194918421835Yes
182469341386.8150.3230.1Site-directed mutagenesis by overlap extension using the polymerase chain reaction. S N Ho, H D Hunt, R M Horton, J K Pullen, L R PeaseGene19892744487Yes
182513861386.034.5934.6The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. H MaedaAdv Enzyme Regul200111384745No
182627701385.071.8235.9A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. J Messing, J VieiraGene19826295880Yes
182713841384.046.6146.6Validation of a decisional conflict scale. A M O'ConnorMed Decis Making19957898294Yes
182813831383.00.00.0Statistical analysis of enzyme kinetic data. W W ClelandMethods Enzymol1979502857Yes
182913821382.032.6632.7Speculations on the functions of the major heat shock and glucose-regulated proteins. H R PelhamCell19862944601Yes
183027641382.00.00.0A protein sequenator. P Edman, G BeggEur J Biochem19676059350Yes
183113811381.00.00.0The genetical evolution of social behaviour. II. W D HamiltonJ Theor Biol19645875340Yes
183213811381.033.0333.0Functions of ceramide in coordinating cellular responses to stress. Y A HannunScience19968943189No
183341411380.3120.7240.2The fusiform face area: a module in human extrastriate cortex specialized for face perception. N Kanwisher, J McDermott, M M ChunJ Neurosci19979151747Yes
183413801380.00.00.0Selection of successive tumour lines for metastasis. I J FidlerNat New Biol19734512654Yes
183513801380.00.00.0The measurement of psychological androgyny. S L BemJ Consult Clin Psychol19744823550Yes
183627601380.062.4631.2An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. A A Beg, D BaltimoreScience19968864118Yes
183713801380.00.00.0Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System. K FuxeActa Physiol Scand Suppl196514319769Yes
183813801380.051.6851.7Falls in older people: epidemiology, risk factors and strategies for prevention. Laurence Z RubensteinAge Ageing200616926202No
183941391379.7141.8247.3Vascular endothelial cells synthesize nitric oxide from L-arginine. R M Palmer, D S Ashton, S MoncadaNature19883131684Yes
184013791379.00.00.0Human cardiovascular adjustments to exercise and thermal stress. L B RowellPhysiol Rev19744587247No
184113791379.036.6136.6Aspergillus fumigatus and aspergillosis. J P LatgéClin Microbiol Rev199910194462No
184227571378.50.00.0Mutations of Bacteria from Virus Sensitivity to Virus Resistance. S E Luria, M DelbrückGenetics194317247100Yes
184355131378.2126.3631.6Probability-based protein identification by searching sequence databases using mass spectrometry data. D N Perkins, D J Pappin, D M Creasy, J S CottrellElectrophoresis199910612281Yes
184413781378.031.0831.1Protein misfolding, evolution and disease. C M DobsonTrends Biochem Sci199910470028No
184513771377.00.00.0Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. C A BarnesJ Comp Physiol Psychol1979221551Yes
184613771377.072.6972.7Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. F E ZajacCrit Rev Biomed Eng19892676342No
184727531376.591.8845.9The efficiency of systematic sampling in stereology and its prediction. H J Gundersen, E B JensenJ Microsc19873430576Yes
184813761376.027.2927.3Vienna RNA secondary structure server. Ivo L HofackerNucleic Acids Res200312824340Yes
184927511375.588.744.4Functional architecture of basal ganglia circuits: neural substrates of parallel processing. G E Alexander, M D CrutcherTrends Neurosci19901695401No
185013751375.033.1933.2Far-field optical nanoscopy. Stefan W HellScience200717525330No
185113741374.00.00.0An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. O SmithiesBiochem J195913638269Yes
185213741374.040.9440.9n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Philip C CalderAm J Clin Nutr200616841861No
185327461373.00.00.0A scaled version of the General Health Questionnaire. D P Goldberg, V F HillierPsychol Med1979424481Yes
185427461373.070.3735.2CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. D G Higgins, P M SharpGene19883243435Yes
185527441372.0100.3350.2Biology of disease: free radicals and tissue injury. B A Freeman, J D CrapoLab Invest19826290784No
185613721372.029.4529.4Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. S S FergusonPharmacol Rev200111171937No
185741151371.7108.7336.2Optimization by simulated annealing. S Kirkpatrick, C D Gelatt, M P VecchiScience198317813860Yes
185827431371.50.00.0Prediction of protein conformation. P Y Chou, G D FasmanBiochemistry19744358940Yes
185927431371.5101.0850.5Neurocircuitry of addiction. George F Koob, Nora D VolkowNeuropsychopharmacology201019710631No
186013711371.039.5939.6Isolation and cultivation of Lyme disease spirochetes. A G BarbourYale J Biol Med19846393604Yes
186113711371.026.4726.5Ubiquitin-dependent protein degradation. M HochstrasserAnnu Rev Genet19968982460No
186213711371.00.00.0Effects of varying the vehicle for OsO4 in tissue fixation. J B CaulfieldJ Biophys Biochem Cytol195713475399Yes
186327411370.559.5529.8Development by self-digestion: molecular mechanisms and biological functions of autophagy. Beth Levine, Daniel J KlionskyDev Cell200415068787No
186413701370.032.5932.6The molecular logic of endocannabinoid signalling. Daniele PiomelliNat Rev Neurosci200314595399No
186527391369.570.235.1Steatohepatitis: a tale of two "hits"? C P Day, O F JamesGastroenterology19989547102No
186627391369.567.5133.8Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. F Q Schafer, G R BuettnerFree Radic Biol Med200111368918No
186727361368.00.00.0Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. A J Berk, P A SharpCell1977922889Yes
186813681368.033.3333.3The basic science of gene therapy. R C MulliganScience19938493530No
186913681368.030.1130.1Neurotrophins as synaptic modulators. M M PooNat Rev Neurosci200111253356No
187013681368.043.5243.5Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. James J P StewartJ Mol Model200717828561Yes
187127351367.559.6229.8Coordination of circadian timing in mammals. Steven M Reppert, David R WeaverNature200212198538No
187227351367.50.00.0The effect of sodium ions on the electrical activity of giant axon of the squid. A L Hodgkin, B KatzJ Physiol194918128147Yes
187313661366.031.7731.8Protein kinase C: structure, function, and regulation. A C NewtonJ Biol Chem19957499357No
187427321366.091.545.8Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. G R Gibson, M B RoberfroidJ Nutr19957782892No
187527301365.063.1831.6Microtubules as a target for anticancer drugs. Mary Ann Jordan, Leslie WilsonNat Rev Cancer200415057285No
187613651365.037.937.9External validity of randomised controlled trials: "to whom do the results of this trial apply?". Peter M RothwellLancet200515639683Yes
187713651365.00.00.0Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples. P F ScholanderJ Biol Chem194720281644Yes
187827291364.562.2131.1Neurotrophins: roles in neuronal development and function. E J Huang, L F ReichardtAnnu Rev Neurosci200111520916No
187913641364.00.00.0Microbial ecology of the gastrointestinal tract. D C SavageAnnu Rev Microbiol1977334036No
188013641364.092.3192.3The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. F C EwaldClin Orthop Relat Res19892805502Yes
188113641364.026.4626.5NK cell receptors. L L LanierAnnu Rev Immunol19989597134No
188227271363.570.3235.2Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. D Marion, K WüthrichBiochem Biophys Res Commun19836307308Yes
188327261363.0101.5850.8Pain assessment: global use of the Brief Pain Inventory. C S Cleeland, K M RyanAnn Acad Med Singap19948080219No
188413621362.047.8347.8Multiple calcium channels and neuronal function. R J MillerScience19872432656No
188527241362.053.2526.6T-cell antigen receptor genes and T-cell recognition. M M Davis, P J BjorkmanNature19883043226No
188613621362.035.4535.5Stress and hippocampal plasticity. B S McEwenAnnu Rev Neurosci199910202533No
188713621362.035.1735.2Myeloperoxidase: friend and foe. Seymour J KlebanoffJ Leukoc Biol200515689384No
188827221361.082.0841.0Glycine potentiates the NMDA response in cultured mouse brain neurons. J W Johnson, P AscherNature19872433595Yes
188913611361.036.8836.9Cell and environment interactions in tumor microregions: the multicell spheroid model. R M SutherlandScience19882451290Yes
189013601360.056.5256.5A structured interview guide for the Hamilton Depression Rating Scale. J B WilliamsArch Gen Psychiatry19883395203Yes
189127201360.057.2628.6Fitting a mixture model by expectation maximization to discover motifs in biopolymers. T L Bailey, C ElkanProc Int Conf Intell Syst Mol Biol19947584402Yes
189227201360.076.0638.0Transforming growth factor beta in tissue fibrosis. W A Border, N A NobleN Engl J Med19947935686No
189327201360.00.00.0Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons. A Dahlstroem, K FuxeActa Physiol Scand Suppl196414229500Yes
189427191359.575.5237.8Early identification of refractory epilepsy. P Kwan, M J BrodieN Engl J Med200010660394Yes
189513591359.00.00.0Codon--anticodon pairing: the wobble hypothesis. F H CrickJ Mol Biol19665969078Yes
189613591359.032.0232.0The NCI60 human tumour cell line anticancer drug screen. Robert H ShoemakerNat Rev Cancer200616990858No
189727171358.590.0345.0Unidentified curved bacilli on gastric epithelium in active chronic gastritis. J R Warren, B MarshallLancet19836134060Yes
189813581358.038.738.7A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. J EngelEpilepsia200111422340Yes
189913581358.00.00.0Note on the sampling error of the difference between correlated proportions or percentages. Q McNEMARPsychometrika194720254758Yes
190013571357.034.8634.9Thioredoxin and glutaredoxin systems. A HolmgrenJ Biol Chem19892668278No
190113571357.030.5630.6Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. M KozakMicrobiol Rev19836343825No
190213571357.043.4343.4The many roles for fluorine in medicinal chemistry. William K HagmannJ Med Chem200818570365Yes
190313561356.00.00.0Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. T SpectorAnal Biochem1978655375Yes
190413561356.00.00.0Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. S S LehrerBiochemistry19715119250Yes
190513561356.057.2257.2Adverse health effects of high-effort/low-reward conditions. J SiegristJ Occup Health Psychol19969547031No
190627121356.081.3840.7Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Sally S Dickerson, Margaret E KemenyPsychol Bull200415122924Yes
190727121356.090.0745.0Density functionals with broad applicability in chemistry. Yan Zhao, Donald G TruhlarAcc Chem Res200818186612Yes
190813561356.00.00.0Potential, Impedance, And Rectification In Membranes. D E GoldmanJ Gen Physiol194319873371Yes
190927111355.50.00.0Immunoassay of endogenous plasma insulin in man. R S Yalow, S A BersonJ Clin Invest196013846364Yes
191027101355.067.5633.8Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. E S Lander, D BotsteinGenetics19892563713Yes
191113551355.037.7637.8Task switching. Stephen MonsellTrends Cogn Sci200312639695Yes
191213551355.031.4331.4Cancer epigenomics: DNA methylomes and histone-modification maps. Manel EstellerNat Rev Genet200717339880No
191313541354.040.4840.5The aging process. D HarmanProc Natl Acad Sci U S A19816947277Yes
191427081354.083.8341.9Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. P J Basser, C PierpaoliJ Magn Reson B19968661285Yes
191513541354.039.8739.9Leishmaniasis: current situation and new perspectives. P DesjeuxComp Immunol Microbiol Infect Dis200415225981No
191613541354.028.5628.6RNA silencing in plants. David BaulcombeNature200415372043No
191713541354.037.8837.9Integration, scaling, space-group assignment and post-refinement. Wolfgang KabschActa Crystallogr D Biol Crystallogr201020124693Yes
191813541354.043.7143.7Systemic lupus erythematosus. George C TsokosN Engl J Med201122129255No
191927071353.571.9436.0Malignant gliomas in adults. Patrick Y Wen, Santosh KesariN Engl J Med200818669428No
192040601353.388.8629.6Toll-like receptors. Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo AkiraAnnu Rev Immunol200312524386No
192140581352.70.00.0Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Garnier, D J Osguthorpe, B RobsonJ Mol Biol1978642007Yes
192294681352.6212.1230.3Embryonic stem cell lines derived from human blastocysts. J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M JonesScience19989804556Yes
192313521352.054.1554.1Cardiac valve surgery--the "French correction". A CarpentierJ Thorac Cardiovasc Surg19836887954Yes
192454071351.80.00.0Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. D W Cleveland, S G Fischer, M W Kirschner, U K LaemmliJ Biol Chem1977320200Yes
192527021351.085.7842.9Performing the exact test of Hardy-Weinberg proportion for multiple alleles. S W Guo, E A ThompsonBiometrics19921637966Yes
192613511351.044.0344.0Glutathione metabolism and its selective modification. A MeisterJ Biol Chem19883053703No
192727011350.5168.484.2Rating systems in the evaluation of knee ligament injuries. Y Tegner, J LysholmClin Orthop Relat Res19854028566Yes
192813501350.045.2645.3Interleukin-1. C A DinarelloRev Infect Dis19846369481No
192927001350.077.8138.9Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. B R Celli, W MacNeeEur Respir J200415219010No
193013491349.031.4831.5Tumor metastasis: mechanistic insights and clinical challenges. Patricia S SteegNat Med200616892035No
193153931348.2160.140.0Comorbidity measures for use with administrative data. A Elixhauser, C Steiner, D R Harris, R M CoffeyMed Care19989431328Yes
193240441348.090.4630.2Telomeres shorten during ageing of human fibroblasts. C B Harley, A B Futcher, C W GreiderNature19902342578Yes
193340431347.70.00.0Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. D D Sabatini, K Bensch, R J BarrnettJ Cell Biol196313975866Yes
193426951347.50.00.0The respiratory chain and oxidative phosphorylation. B Chance, G R WilliamsAdv Enzymol Relat Subj Biochem195613313307Yes
193513471347.034.7634.8An economic method for the fluorescent labeling of PCR fragments. M SchuelkeNat Biotechnol200010657137Yes
193626921346.00.00.0The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. J O'Keefe, J DostrovskyBrain Res19715124915Yes
193726921346.063.531.8Lipopolysaccharide endotoxins. Christian R H Raetz, Chris WhitfieldAnnu Rev Biochem200212045108No
193813461346.00.00.0Cerebral vascular accidents in patients over the age of 60. II. Prognosis. J RankinScott Med J195713432835Yes
193913451345.044.0444.0Efficient analysis of experimental observations. W J DixonAnnu Rev Pharmacol Toxicol19807387124Yes
194013451345.032.0132.0Ordered porous materials for emerging applications. Mark E DavisNature200212075343No
194126881344.055.6827.8Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. P J Southern, P BergJ Mol Appl Genet19826286831Yes
194226861343.00.00.0Further improvements in the plaque technique for detecting single antibody-forming cells. A J Cunningham, A SzenbergImmunology19685653817Yes
194326861343.0108.4154.2Assessment of eating disorders: interview or self-report questionnaire? C G Fairburn, S J BeglinInt J Eat Disord19947866415Yes
194413431343.00.00.0A modified procedure for lead staining of thin sections. G MillonigJ Biophys Biochem Cytol196114474176Yes
194513421342.00.00.0Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. J R DavidProc Natl Acad Sci U S A19665229858Yes
194613421342.00.00.0A simple ultraviolet spectrophotometric method for the determination of protein. W J WaddellJ Lab Clin Med195613346201Yes
194713411341.00.00.0Blood gas calculator. J W SeveringhausJ Appl Physiol19665912737Yes
194813411341.039.639.6Glycobiology: Toward Understanding the Function of Sugars. Raymond A. DwekChem Rev199611848770Yes
194926821341.083.8241.9Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. James J Gross, Oliver P JohnJ Pers Soc Psychol200312916575Yes
195013411341.034.1434.1Five rules for the evolution of cooperation. Martin A NowakScience200617158317No
195113411341.042.5142.5Surface plasmon resonance sensors for detection of chemical and biological species. Jirí HomolaChem Rev200818229953No
195226811340.5101.650.8The need to belong: desire for interpersonal attachments as a fundamental human motivation. R F Baumeister, M R LearyPsychol Bull19957777651No
195313401340.033.1633.2Neuronal synchrony: a versatile code for the definition of relations? W SingerNeuron199910677026No
195426791339.553.9127.0The evolutionary fate and consequences of duplicate genes. M Lynch, J S ConeryScience200011073452No
195513391339.044.344.3Social relationships and health. Sheldon CohenAm Psychol200415554821No
195613391339.036.436.4Use and misuse of the receiver operating characteristic curve in risk prediction. Nancy R CookCirculation200717309939Yes
195726771338.566.1533.1Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. H Cai, D G HarrisonCirc Res200011073878No
195826771338.572.5836.3Obesity. David W Haslam, W Philip T JamesLancet200516198769No
195940131337.796.1732.1Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Hartmuth C. Kolb, M. G. Finn, K. Barry SharplessAngew Chem Int Ed Engl200111433435Yes
196026731336.50.00.0Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. E Engvall, P PerlmannJ Immunol19724113792Yes
196126721336.00.00.0Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. R L Heath, L PackerArch Biochem Biophys19685655425Yes
196213361336.063.9864.0The emerging role of lncRNAs in cancer. Maite HuarteNat Med201526540387No
196326701335.062.231.1NF-kappaB: a key role in inflammatory diseases. P P Tak, G S FiresteinJ Clin Invest200111134171No
196426701335.062.3131.2Cancer metastasis: building a framework. Gaorav P Gupta, Joan MassaguéCell200617110329No
196513351335.035.0935.1The failing heart--an engine out of fuel. Stefan NeubauerN Engl J Med200717360992No
196653391334.8163.9741.0The validity of the Hospital Anxiety and Depression Scale. An updated literature review. Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag NeckelmannJ Psychosom Res200211832252No
196726691334.50.00.0Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. G J Miller, N E MillerLancet197546338Yes
196826681334.00.00.0Synchronization of Plasmodium falciparum erythrocytic stages in culture. C Lambros, J P VanderbergJ Parasitol1979383936Yes
196913341334.048.3848.4Colorimetric determination of phospholipids with ammonium ferrothiocyanate. J C StewartAnal Biochem19806892980Yes
197026681334.063.0831.5NF-kappa B: ten years after. P A Baeuerle, D BaltimoreCell19968858144No
197126681334.078.1839.1Mortality by cause for eight regions of the world: Global Burden of Disease Study. C J Murray, A D LopezLancet19979142060Yes
197213331333.032.7632.8Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. G von HeijneJ Mol Biol19921593632Yes
197313331333.043.6343.6Equipoise and the ethics of clinical research. B FreedmanN Engl J Med19873600702Yes
197426651332.579.8739.9EQ-5D: a measure of health status from the EuroQol Group. R Rabin, F de CharroAnn Med200111491192No
197513321332.027.627.6Macromolecular crowding: obvious but underappreciated. R J EllisTrends Biochem Sci200111590012No
197613321332.00.00.0Immunological function of the thymus. J F MillerLancet196114474038Yes
197739951331.790.9630.3TOR signaling in growth and metabolism. Stephan Wullschleger, Robbie Loewith, Michael N HallCell200616469695No
197826601330.00.00.0Selective loss of central cholinergic neurons in Alzheimer's disease. P Davies, A J MaloneyLancet197663862Yes
197913301330.037.8637.9The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. R G GerrityAm J Pathol19817234961Yes
198013301330.029.0529.1The Buccaneer software for automated model building. 1. Tracing protein chains. Kevin CowtanActa Crystallogr D Biol Crystallogr200616929101Yes
198126601330.086.1843.1Mechanisms of salinity tolerance. Rana Munns, Mark TesterAnnu Rev Plant Biol200818444910No
198213291329.00.00.0The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. R C LewontinGenetics196417248194Yes
198326561328.067.2533.6Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. M D Pierschbacher, E RuoslahtiNature19846325925Yes
198426551327.576.9838.5Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. F D Lublin, S C ReingoldNeurology19968780061Yes
1985119451327.2449.5650.0STAR: ultrafast universal RNA-seq aligner. Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R GingerasBioinformatics201323104886Yes
198613271327.045.1945.2Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. N KriegerAm J Public Health19921566949Yes
198713271327.041.5741.6Neurotransmitters and neuromodulators in the basal ganglia. A M GraybielTrends Neurosci19901695398No
198813271327.036.3336.3Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. S L FriedmanN Engl J Med19938502273No
198913261326.00.00.0Stereological principles for morphometry in electron microscopic cytology. E R WeibelInt Rev Cytol19694899604No
199013261326.036.1636.2A more meaningful scoring system for determining the severity of coronary heart disease. G G GensiniAm J Cardiol19836823874Yes
199113251325.032.3232.3Two pathogenetic types of endometrial carcinoma. J V BokhmanGynecol Oncol19836822361Yes
199213251325.040.9641.0Semiempirical hybrid density functional with perturbative second-order correlation. Stefan GrimmeJ Chem Phys200616438568Yes
199326481324.0110.4555.2Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. A Y Finlay, G K KhanClin Exp Dermatol19948033378Yes
199413231323.00.00.0Electrophoretic separation of plasma lipoproteins in agarose gel. R P NobleJ Lipid Res19684176473Yes
199526461323.00.00.0Peptidoglycan types of bacterial cell walls and their taxonomic implications. K H Schleifer, O KandlerBacteriol Rev19724568761No
199626461323.00.00.0Immunization of dissociated spleen cell cultures from normal mice. R I Mishell, R W DuttonJ Exp Med19676034749Yes
199713231323.065.0965.1Molecular pathology of schizophrenia: more than one disease process? T J CrowBr Med J19806101544No
199813231323.033.0433.0Oxidative stress in Parkinson's disease. Peter JennerAnn Neurol200312666096No
199926451322.50.00.0Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. E Engvall, P PerlmannImmunochemistry19715135623Yes
200013221322.025.0225.0The DNA methyltransferases of mammals. T H BestorHum Mol Genet200011005794No
200113221322.035.6635.7Hydrogels for biomedical applications. Allan S HoffmanAdv Drug Deliv Rev200211755703No
200213211321.031.2531.2Hematopoietic stem-cell transplantation. Edward A CopelanN Engl J Med200616641398No
200326411320.594.847.4A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. C M Tsai, C E FraschAnal Biochem19826176137Yes
200426411320.582.9941.5From best evidence to best practice: effective implementation of change in patients' care. Richard Grol, Jeremy GrimshawLancet200314568747No
200513201320.00.00.0Origin of concatemeric T7 DNA. J D WatsonNat New Biol19724507727Yes
200613201320.027.2727.3Dimerization of cell surface receptors in signal transduction. C H HeldinCell19957834741No
200726401320.068.6734.3Molecular beacons: probes that fluoresce upon hybridization. S Tyagi, F R KramerNat Biotechnol19969630890Yes
200826401320.0105.9153.0Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. Sarvajeet Singh Gill, Narendra TutejaPlant Physiol Biochem201020870416No
200913201320.066.0366.0Gctf: Real-time CTF determination and correction. Kai ZhangJ Struct Biol201626592709Yes
201026391319.595.5547.8The Oswestry Disability Index. J C Fairbank, P B PynsentSpine (Phila Pa 1976)200011074683No
201139571319.0100.0833.4Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck ØrntoftCancer Res200415289330Yes
201226371318.50.00.0Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. G Blobel, B DobbersteinJ Cell Biol1975811671Yes
201313181318.00.00.0Renin-angiotensin system: biochemistry and mechanisms of action. M J PeachPhysiol Rev1977191856No
201413181318.00.00.0A quantitative immunochemical measure of the primary interaction between I BSA and antibody. R S FarrJ Infect Dis195813611294Yes
201513181318.034.6834.7The amygdala modulates the consolidation of memories of emotionally arousing experiences. James L McGaughAnnu Rev Neurosci200415217324No
201626351317.554.5827.3Cancer genes and the pathways they control. Bert Vogelstein, Kenneth W KinzlerNat Med200415286780No
201713171317.047.6547.6Neuropeptide Y: complete amino acid sequence of the brain peptide. K TatemotoProc Natl Acad Sci U S A19826957876Yes
201813171317.061.8561.9Pro-resolving lipid mediators are leads for resolution physiology. Charles N SerhanNature201424899309No
201913161316.033.733.7The use of nanocrystals in biological detection. Paul AlivisatosNat Biotechnol200414704706Yes
202052621315.5125.3631.3Quantitative monitoring of gene expression patterns with a complementary DNA microarray. M Schena, D Shalon, R W Davis, P O BrownScience19957569999Yes
202126311315.50.00.0Virus interference. I. The interferon. A Isaacs, J LindenmannProc R Soc Lond B Biol Sci195713465720Yes
202278921315.3272.8545.5New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier GascuelSyst Biol201020525638Yes
202313151315.00.00.0Cellular resistance to infection. G B MackanessJ Exp Med196214467923Yes
202426301315.056.5528.3Intrinsically unstructured proteins and their functions. H Jane Dyson, Peter E WrightNat Rev Mol Cell Biol200515738986No
202526301315.068.7634.4Unravelling the pathogenesis of inflammatory bowel disease. R J Xavier, D K PodolskyNature200717653185No
202613141314.041.4441.4Domino Reactions in Organic Synthesis. Lutz F. TietzeChem Rev199611848746Yes
202713131313.026.0726.1Chromosomal translocations in human cancer. T H RabbittsNature19947969446No
202813131313.00.00.0The antidiuretic hormone and the factors which determine its release. E B VerneyProc R Soc Lond B Biol Sci194718918876Yes
202939381312.7139.6946.6Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. Aleksandr V Marenich, Christopher J Cramer, Donald G TruhlarJ Phys Chem B200919366259Yes
203026231311.50.00.0Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. D H Figurski, D R HelinskiProc Natl Acad Sci U S A1979377280Yes
203113111311.00.00.0Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. W W DouglasBr J Pharmacol19684882190No
203213111311.025.4725.5Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. M G GustafssonJ Microsc200010810003Yes
203326211310.560.8430.4Integrins and signal transduction pathways: the road taken. E A Clark, J S BruggeScience19957716514No
203426191309.551.1925.6Oncogenic kinase signalling. P Blume-Jensen, T HunterNature200111357143No
203513091309.034.5434.5The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. K KuwajimaProteins19892695928No
203613091309.035.3335.3Fibronectin and its receptors. E RuoslahtiAnnu Rev Biochem19882972252No
203713091309.032.1132.1Neurotrophin-regulated signalling pathways. Louis F ReichardtPhilos Trans R Soc Lond B Biol Sci200616939974No
203813081308.00.00.0Letter: Grading of angina pectoris. L CampeauCirculation1976947585Yes
203913081308.041.7941.8The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. L W SwansonBrain Res Bull19826816390Yes
204026151307.559.8529.9Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. E Y Chen, P H SeeburgDNA19853996185Yes
204126141307.060.3330.2Self-assembly at all scales. George M Whitesides, Bartosz GrzybowskiScience200211923529Yes
204239211307.0142.0747.4Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Helga Thorvaldsdóttir, James T Robinson, Jill P MesirovBrief Bioinform201322517427Yes
2043169811306.2481.7837.1Clustal W and Clustal X version 2.0. M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G HigginsBioinformatics200717846036Yes
204413061306.042.9442.9History of the Rochester Epidemiology Project. L J MeltonMayo Clin Proc19968594285No
204513061306.030.7230.7The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. S E KahnDiabetologia200312637977No
204613051305.00.00.0Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism. H M KalckarJ Biol Chem194720285041Yes
204713041304.041.5541.5The phenomenon of the acute phase response. I KushnerAnn N Y Acad Sci19827046585No
204813041304.031.4731.5Apoptosis in cancer therapy: crossing the threshold. D E FisherCell19948069905No
204913041304.00.00.0Agammaglobulinemia. O C BrutonPediatrics195214929630Yes
205013031303.036.0936.1The world health report 2002 - reducing risks, promoting healthy life. J J GuilbertEduc Health (Abingdon)200314741909Yes
205139071302.3129.0443.0Estimating the mean and variance from the median, range, and the size of a sample. Stela Pudar Hozo, Benjamin Djulbegovic, Iztok HozoBMC Med Res Methodol200515840177Yes
205213021302.037.2737.3The matrix-degrading metalloproteinases. L M MatrisianBioessays19921445287No
205339061302.098.0232.7The p53 tumour suppressor gene. A J Levine, J Momand, C A FinlayNature19912046748No
205426041302.060.8530.4The RXR heterodimers and orphan receptors. D J Mangelsdorf, R M EvansCell19958521508No
205513021302.034.2634.3N-heterocyclic carbenes: a new concept in organometallic catalysis. Wolfgang A HerrmannAngew Chem Int Ed Engl200219750753Yes
205652061301.5307.7276.9Prevalence of childhood and adult obesity in the United States, 2011-2012. Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M FlegalJAMA201424570244Yes
205713011301.028.1728.2Double identity for proteins of the Bcl-2 family. J C ReedNature19979194558No
205813011301.046.5946.6The polyvagal perspective. Stephen W PorgesBiol Psychol200717049418No
205925991299.561.6830.8The pathophysiology and treatment of sepsis. Richard S Hotchkiss, Irene E KarlN Engl J Med200312519925No
206012991299.050.5550.5Free-radical mechanisms in tissue injury. T F SlaterBiochem J19846383353No
206125981299.078.1939.1Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. C J Murray, A D LopezLancet19979164317Yes
206212981298.044.4344.4Gene flow and the geographic structure of natural populations. M SlatkinScience19873576198Yes
206312981298.029.6429.6Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. W D SniderCell19948205613No
206412981298.041.0741.1Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. M Robin DiMatteoMed Care200415076819Yes
206512961296.033.6733.7Lead- and drug-like compounds: the rule-of-five revolution. Christopher A LipinskiDrug Discov Today Technol200424981612Yes
206612961296.073.1273.1The biology and function of fibroblasts in cancer. Raghu KalluriNat Rev Cancer201627550820No
206751811295.2141.5335.4Most mammalian mRNAs are conserved targets of microRNAs. Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P BartelGenome Res200918955434Yes
206812951295.032.9232.9Tobacco smoke carcinogens and lung cancer. S S HechtJ Natl Cancer Inst199910413421No
206912951295.025.8725.9Epithelial-mesenchymal transitions in development and pathologies. Jean Paul ThieryCurr Opin Cell Biol200314644200No
207012931293.030.6730.7Hyaluronan: from extracellular glue to pericellular cue. Bryan P TooleNat Rev Cancer200415229478No
207112931293.043.9143.9Stress signalling pathways that impair prefrontal cortex structure and function. Amy F T ArnstenNat Rev Neurosci200919455173No
207225861293.0112.7856.4Regulation of microRNA biogenesis. Minju Ha, V Narry KimNat Rev Mol Cell Biol201425027649No
207325851292.554.0927.0Wnt signalling in stem cells and cancer. Tannishtha Reya, Hans CleversNature200515829953No
207412921292.029.5729.6Cancer of the ovary. Stephen A CannistraN Engl J Med200415590954No
207525821291.061.7730.9Production of single-stranded plasmid DNA. J Vieira, J MessingMethods Enzymol19873323803Yes
207612911291.031.4531.4Regulation of differentiation of vascular smooth muscle cells. G K OwensPhysiol Rev19957624392No
207712911291.029.4129.4A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Dale R NyholtAm J Hum Genet200414997420Yes
207812901290.00.00.0Stability of proteins: small globular proteins. P L PrivalovAdv Protein Chem197944431No
207912901290.041.7741.8Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. A A GraceNeuroscience19911676137No
208012891289.034.9635.0Signaling through phosphatidylcholine breakdown. J H ExtonJ Biol Chem19902104616No
208112891289.050.150.1Presidential address, 1980. Surprise!...Surprise? E DonchinPsychophysiology19817280146Yes
208225781289.095.7547.9Saliency, switching, attention and control: a network model of insula function. Vinod Menon, Lucina Q UddinBrain Struct Funct201020512370No
208312891289.080.8680.9Deep learning in neural networks: an overview. Jürgen SchmidhuberNeural Netw201525462637No
208438661288.7117.2539.1Regularization Paths for Generalized Linear Models via Coordinate Descent. Jerome Friedman, Trevor Hastie, Rob TibshiraniJ Stat Softw201020808728Yes
208525771288.576.9338.5Materials for electrochemical capacitors. Patrice Simon, Yury GogotsiNat Mater200818956000Yes
208612881288.028.1428.1The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. G B MorinCell19892805070Yes
208712881288.047.3847.4Substance P. B PernowPharmacol Rev19836196797No
208812881288.043.1143.1The functional gastrointestinal disorders and the Rome III process. Douglas A DrossmanGastroenterology200616678553No
208925751287.556.1328.1The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. M S Brown, J L GoldsteinCell19979150132No
209038621287.389.529.8Osteoclast differentiation and activation. William J Boyle, W Scott Simonet, David L LaceyNature200312748652No
209112871287.033.6633.7Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. Y ShaiBiochim Biophys Acta199910590302No
209225731286.50.00.0Epidermal growth factor. G Carpenter, S CohenAnnu Rev Biochem1979382984No
209325721286.00.00.0Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. J A Ledbetter, L A HerzenbergImmunol Rev1979398327No
209412861286.024.324.3Chromatin modification and epigenetic reprogramming in mammalian development. En LiNat Rev Genet200212209141No
209525711285.50.00.0A new scale of social desirability independent of psychopathology. D P Crowne, D MarloweJ Consult Psychol196013813058Yes
209612851285.031.131.1Receptors for epidermal growth factor and other polypeptide mitogens. G CarpenterAnnu Rev Biochem19873039909No
209712851285.00.00.0Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents. A BöyumScand J Clin Lab Invest Suppl19684179066Yes
209812851285.033.0633.1A molecular view of microbial diversity and the biosphere. N R PaceScience19979115194No
209912851285.027.4327.4Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. R I MorimotoGenes Dev19989869631No
210025691284.50.00.0A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. R L Juliano, V LingBiochim Biophys Acta1976990323Yes
210125691284.571.7135.9Macrophage diversity enhances tumor progression and metastasis. Bin-Zhi Qian, Jeffrey W PollardCell201020371344No
210225681284.00.00.0Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. L F Berkman, S L SymeAm J Epidemiol1979425958Yes
210312841284.034.2534.2Phylogenies from molecular sequences: inference and reliability. J FelsensteinAnnu Rev Genet19883071258No
210412841284.030.4830.5Molecular basis of long-term plasticity underlying addiction. E J NestlerNat Rev Neurosci200111252991No
210538521284.0172.5857.5Molecular mechanisms of epithelial-mesenchymal transition. Samy Lamouille, Jian Xu, Rik DerynckNat Rev Mol Cell Biol201424556840No
210625681284.0118.9459.5Deciphering key features in protein structures with the new ENDscript server. Xavier Robert, Patrice GouetNucleic Acids Res201424753421Yes
210725671283.50.00.0Regulatory sequences involved in the promotion and termination of RNA transcription. M Rosenberg, D CourtAnnu Rev Genet197994251No
210812831283.053.853.8Sample size in qualitative research. M SandelowskiRes Nurs Health19957899572Yes
210925661283.059.4129.7Disruption of epithelial cell-matrix interactions induces apoptosis. S M Frisch, H FrancisJ Cell Biol19948106557Yes
211038481282.70.00.0Improved method for the determination of blood glutathione. E Beutler, O Duron, B M KellyJ Lab Clin Med196313967893Yes
211125651282.554.7627.4Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. J M Kyriakis, J AvruchPhysiol Rev200111274345No
211212821282.00.00.0Cardiovascular and renal actions of dopamine: potential clinical applications. L I GoldbergPharmacol Rev19724554480No
211312821282.030.0830.1Autophagy: from phenomenology to molecular understanding in less than a decade. Daniel J KlionskyNat Rev Mol Cell Biol200717712358No
211412811281.036.2136.2Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Michael F HolickAm J Clin Nutr200415585788No
211512811281.047.4847.5The global impact of pre-eclampsia and eclampsia. Lelia DuleySemin Perinatol200919464502No
211664031280.6289.457.9UCHIME improves sensitivity and speed of chimera detection. Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob KnightBioinformatics201121700674Yes
211725611280.556.6828.3NMR View: A computer program for the visualization and analysis of NMR data. B A Johnson, R A BlevinsJ Biomol NMR199422911360Yes
211812801280.00.00.0Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. J H LuftAnat Rec19714108333Yes
211938401280.0101.9634.0Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. B Fischl, M I Sereno, A M DaleNeuroimage19999931269Yes
212012801280.035.6635.7A note on robust variance estimation for cluster-correlated data. R L WilliamsBiometrics200010877330Yes
212112801280.024.3624.4CD95's deadly mission in the immune system. P H KrammerNature200011048730No
212212791279.026.526.5Natively unfolded proteins: a point where biology waits for physics. Vladimir N UverskyProtein Sci200211910019No
212325581279.060.330.1A comparison of bayesian methods for haplotype reconstruction from population genotype data. Matthew Stephens, Peter DonnellyAm J Hum Genet200314574645Yes
212451141278.5128.7932.2Improved prediction of signal peptides: SignalP 3.0. Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren BrunakJ Mol Biol200415223320Yes
212512781278.022.2422.2Cancer. Addiction to oncogenes--the Achilles heal of cancer. I Bernard WeinsteinScience200212098689No
212612781278.064.2764.3What's in a name? Qualitative description revisited. Margarete SandelowskiRes Nurs Health201020014004Yes
212712771277.029.1329.1The ATP synthase--a splendid molecular machine. P D BoyerAnnu Rev Biochem19979242922No
212812771277.00.00.0The Relation Of Recombination To Mutational Advance. H J MullerMutat Res196414195748Yes
212938301276.7138.2646.1Structure-antioxidant activity relationships of flavonoids and phenolic acids. C A Rice-Evans, N J Miller, G PagangaFree Radic Biol Med19968743980Yes
213012761276.00.00.0Hippocampal electrical activity and voluntary movement in the rat. C H VanderwolfElectroencephalogr Clin Neurophysiol19694183562Yes
213125501275.00.00.0A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. B G Durie, S E SalmonCancer19751182674Yes
213212751275.084.9885.0The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. F DenisSpine (Phila Pa 1976)19836670016Yes
213312751275.030.7530.8Lymphokine production by human T cells in disease states. S RomagnaniAnnu Rev Immunol19948011282No
213412751275.032.6132.6Upconversion and anti-Stokes processes with f and d ions in solids. François AuzelChem Rev200414719973Yes
213512751275.032.9733.0Drug-induced prolongation of the QT interval. Dan M RodenN Engl J Med200414999113No
213612751275.034.0734.1Origin, biogenesis, and activity of plant microRNAs. Olivier VoinnetCell200919239888No
213712741274.00.00.0Mate selection-a selection for a handicap. A ZahaviJ Theor Biol19751195756Yes
213825481274.051.3925.7Autophagy as a regulated pathway of cellular degradation. D J Klionsky, S D EmrScience200011099404No
213912741274.044.9845.0Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. K Anders EricssonAcad Med200415383395No
214012741274.040.0440.0Recent developments in isocyanide based multicomponent reactions in applied chemistry. Alexander DömlingChem Rev200616402771No
214125471273.547.423.7New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. R D Gietz, A SuginoGene19883073106Yes
214212731273.044.6544.6Functional organization of central pathways regulating the cardiovascular system. R A DampneyPhysiol Rev19948171117No
214338181272.7182.7360.9Risk factors for falls among elderly persons living in the community. M E Tinetti, M Speechley, S F GinterN Engl J Med19883205267Yes
214425451272.543.0321.5Genetic transformation of Drosophila with transposable element vectors. G M Rubin, A C SpradlingScience19826289436Yes
214512721272.038.8938.9Diversity and ubiquity of K channels. B RudyNeuroscience19882457185No
214612721272.024.1424.1Antigen-specific interaction between T and B cells. A LanzavecchiaNature19853157869Yes
214712721272.055.2855.3The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. E J KhantzianAm J Psychiatry19853904487No
214825421271.076.3138.2Lipid rafts as a membrane-organizing principle. Daniel Lingwood, Kai SimonsScience201020044567No
214988891269.9447.9464.0limma powers differential expression analyses for RNA-sequencing and microarray studies. Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K SmythNucleic Acids Res201525605792Yes
215050781269.5129.7832.4The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten SchwedeBioinformatics200616301204Yes
215112691269.041.9341.9Somatostatin. S ReichlinN Engl J Med19836139753No
215212691269.035.4735.5The epidemiology of venous thromboembolism. Richard H WhiteCirculation200312814979No
215325361268.00.00.0Establishment and characterization of a human histiocytic lymphoma cell line (U-937). C Sundström, K NilssonInt J Cancer1976178611Yes
215412681268.033.6933.7The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. T SzkudelskiPhysiol Res200111829314No
215512681268.00.00.0Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry. Russell LandeEvolution197928568194Yes
215612671267.023.2423.2Regulatory T cells: key controllers of immunologic self-tolerance. S SakaguchiCell200010850488No
215725341267.081.5940.8Protective and pathogenic functions of macrophage subsets. Peter J Murray, Thomas A WynnNat Rev Immunol201121997792No
215812671267.087.3187.3The antibiotic resistance crisis: part 1: causes and threats. C Lee VentolaP T201525859123Yes
215912661266.049.5549.5Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. Peter C AustinPharm Stat201120925139Yes
216025301265.00.00.0Glutathione peroxidase activity in selenium-deficient rat liver. R A Lawrence, R F BurkBiochem Biophys Res Commun1976971321Yes
216125301265.055.4327.7Liver regeneration. G K Michalopoulos, M C DeFrancesScience19979082986No
216212651265.034.2834.3The importance of the ratio of omega-6/omega-3 essential fatty acids. A P SimopoulosBiomed Pharmacother200212442909No
216325291264.50.00.0Functions of lysosomes. C De Duve, R WattiauxAnnu Rev Physiol19665322983No
216412641264.00.00.0The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. R G KhalifahJ Biol Chem19714994926Yes
216512641264.046.846.8A Social Neuroscience Perspective on Adolescent Risk-Taking. Laurence SteinbergDev Rev200818509515Yes
216625261263.00.00.0A rapid, sensitive, and specific method for the determination of protein in dilute solution. W Schaffner, C WeissmannAnal Biochem19734128882Yes
216725261263.087.0243.5Thermodynamics of protein association reactions: forces contributing to stability. P D Ross, S SubramanianBiochemistry19817248271Yes
216812631263.029.029.0Target-oriented and diversity-oriented organic synthesis in drug discovery. S L SchreiberScience200010720315No
216950511262.8223.8556.0Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanInt J Surg201020171303No
217012621262.022.7422.7Clonal selection and learning in the antibody system. K RajewskyNature19968657279No
217112621262.045.3145.3The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. E J KhantzianHarv Rev Psychiatry19979385000No
217212621262.023.6123.6The snail superfamily of zinc-finger transcription factors. M Angela NietoNat Rev Mol Cell Biol200211994736No
217325231261.50.00.0The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. J Shine, L DalgarnoProc Natl Acad Sci U S A19744598299Yes
217425231261.549.6624.8Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. M Fried, D M CrothersNucleic Acids Res19816275366Yes
217525211260.50.00.0Prediction of the secondary structure of proteins from their amino acid sequence. P Y Chou, G D FasmanAdv Enzymol Relat Areas Mol Biol1978364941No
217612601260.047.9548.0The life and times of the Enterococcus. B E MurrayClin Microbiol Rev19902404568No
217712601260.031.9832.0Apoptosis. J J CohenImmunol Today19938466628No
217812601260.042.1242.1Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Thomas HebererToxicol Lett200211988354Yes
217925191259.562.5531.3Multipoint quantitative-trait linkage analysis in general pedigrees. L Almasy, J BlangeroAm J Hum Genet19989545414Yes
218025161258.067.6233.8Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. J L Weber, P E MayAm J Hum Genet19892916582Yes
218112581258.00.00.0Structure and function of intercellular junctions. L A StaehelinInt Rev Cytol19744611943No
218212581258.033.6733.7The aryl hydrocarbon receptor complex. O HankinsonAnnu Rev Pharmacol Toxicol19957598497No
218312581258.00.00.0A New Weighting System For Mean Surface Temperature Of The Human Body. N L RamanathanJ Appl Physiol196414173555Yes
218412571257.040.2340.2Biological basis of the behavior of sick animals. B L HartNeurosci Biobehav Rev19883050629No
218512571257.00.00.0Strategy and tactics in protein chemistry. B S HartleyBiochem J19704923920No
218612571257.033.433.4Supported membranes: scientific and practical applications. E SackmannScience19968539599No
218712571257.038.4938.5The debate over dopamine's role in reward: the case for incentive salience. Kent C BerridgePsychopharmacology (Berl)200717072591No
218825141257.081.4940.7A perspective on cancer cell metastasis. Christine L Chaffer, Robert A WeinbergScience201121436443No
218925131256.589.9245.0Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. M M Bradley, P J LangJ Behav Ther Exp Psychiatry19947962581Yes
219062821256.40.00.0Enzymatic determination of total serum cholesterol. C C Allain, L S Poon, C S Chan, W Richmond, P C FuClin Chem19744818200Yes
219112561256.026.226.2SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. S V EvansJ Mol Graph19938347566Yes
219212561256.035.3735.4Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. P LipsEndocr Rev200111493580No
219312561256.029.0629.1Critical period plasticity in local cortical circuits. Takao K HenschNat Rev Neurosci200516261181No
219437671255.7103.1434.4The metabolic syndrome. Robert H Eckel, Scott M Grundy, Paul Z ZimmetLancet200515836891No
219525101255.00.00.0Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. A Fabiato, F FabiatoJ Physiol (Paris)1979533865Yes
219612551255.052.3352.3Error in medicine. L L LeapeJAMA19947503827Yes
219737651255.0104.9635.0TCS: a computer program to estimate gene genealogies. M Clement, D Posada, K A CrandallMol Ecol200011050560Yes
219812551255.033.6933.7Interoception: the sense of the physiological condition of the body. A D CraigCurr Opin Neurobiol200312965300No
219925091254.554.5727.3A guided tour into subcellular colocalization analysis in light microscopy. S Bolte, F P CordelièresJ Microsc200617210054Yes
220012541254.043.2643.3Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. R LotanBiochim Biophys Acta19806989400No
220112541254.022.9623.0Protein modification by SUMO. Erica S JohnsonAnnu Rev Biochem200415189146No
220237611253.7118.039.3Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. S van der Linden, H A Valkenburg, A CatsArthritis Rheum19846231933Yes
220337611253.794.6531.6Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Daniel Falush, Matthew Stephens, Jonathan K PritchardGenetics200312930761Yes
220412531253.026.2826.3Signal transduction via the MAP kinases: proceed at your own RSK. J BlenisProc Natl Acad Sci U S A19938392180No
220512531253.042.542.5SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. B P O'ConnorBehav Res Methods Instrum Comput200011029811Yes
220612531253.030.8530.9Cell signaling. H2O2, a necessary evil for cell signaling. Sue Goo RheeScience200616809515Yes
220712531253.042.2142.2Formation of glasses from liquids and biopolymers. C A AngellScience199517770101Yes
220825051252.50.00.0A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. J A Horne, O OstbergInt J Chronobiol19761027738Yes
220912521252.028.1628.2Stability and flexibility of epigenetic gene regulation in mammalian development. Wolf ReikNature200717522676No
221012521252.00.00.0Limitations of the application of fourfold table analysis to hospital data. J BerksonBiometrics194621001024Yes
221112511251.025.8425.8Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. R H SchwartzCell19921335362No
221212511251.050.7150.7Reliability and factor analysis of the Epworth Sleepiness Scale. M W JohnsSleep19921519015Yes
221312511251.00.00.0The prevalence of 'alexithymic' characteristics in psychosomatic patients. P E SifneosPsychother Psychosom19734770536Yes
221412511251.043.4743.5The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. Poul Erik PetersenCommunity Dent Oral Epidemiol200315015736Yes
221525011250.558.0829.0DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. S Tabor, C C RichardsonProc Natl Acad Sci U S A19873474623Yes
221625001250.076.4738.2What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. J Zhang, K F YuJAMA19989832001Yes
221712501250.033.7133.7Hemispheric asymmetry reduction in older adults: the HAROLD model. Roberto CabezaPsychol Aging200211931290No
221825001250.079.1439.6miRBase: integrating microRNA annotation and deep-sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res201121037258Yes
221912491249.00.00.0A modification of receptor theory. R P StephensonBr J Pharmacol Chemother195613383117Yes
222012491249.023.823.8The significance of responses of the genome to challenge. B McClintockScience198415739260No
222112481248.047.3647.4Quantitative methods in the review of epidemiologic literature. S GreenlandEpidemiol Rev19873678409Yes
222212471247.028.3628.4Life, death, and the pursuit of apoptosis. E WhiteGenes Dev19968557188No
222324941247.00.00.0The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. B N Ames, D T DubinJ Biol Chem196013793161Yes
222424931246.578.9639.5Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J E Hixson, D T VernierJ Lipid Res19902341813Yes
222512461246.028.8128.8Chemistry and biology of the immunophilins and their immunosuppressive ligands. S L SchreiberScience19911702904No
222612461246.028.4428.4Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. T A SpringerAnnu Rev Physiol19957778885No
222787161245.1273.5139.1Cancer statistics, 2008. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J ThunCA Cancer J Clin200818287387Yes
222812451245.044.7344.7Carnitine--metabolism and functions. J BremerPhysiol Rev19836361812No
222912451245.038.3438.3Osteoblast adhesion on biomaterials. K AnselmeBiomaterials200010711964No
223024901245.055.9428.0Mitochondrial control of cell death. G Kroemer, J C ReedNat Med200010802706No
223112451245.036.8936.9Bioactive microbial metabolites. János BérdyJ Antibiot (Tokyo)200515813176No
223237341244.7100.8433.6How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. R M Sapolsky, L M Romero, A U MunckEndocr Rev200010696570No
223312441244.030.4530.4Papillomavirus infections--a major cause of human cancers. H zur HausenBiochim Biophys Acta19968876633No
223412441244.029.5729.6Mitochondria: dynamic organelles in disease, aging, and development. David C ChanCell200616814712No
223512441244.0114.91114.9Minimap2: pairwise alignment for nucleotide sequences. Heng LiBioinformatics201829750242Yes
223624871243.583.7341.9The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. W R Gibb, A J LeesJ Neurol Neurosurg Psychiatry19882841426No
223724871243.587.6843.8The pathogenesis of rheumatoid arthritis. Iain B McInnes, Georg SchettN Engl J Med201122150039No
223812431243.030.4230.4Short-term synaptic plasticity. R S ZuckerAnnu Rev Neurosci19892648947No
223924851242.555.3627.7Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. M Zuker, P StieglerNucleic Acids Res19816163133Yes
224012421242.00.00.0Sequential tests for the detection of linkage. N E MortonAm J Hum Genet195513258560Yes
224124831241.566.3233.2Apoptosis, oncosis, and necrosis. An overview of cell death. G Majno, I JorisAm J Pathol19957856735No
224224831241.569.0534.5Abdominal obesity and metabolic syndrome. Jean-Pierre Després, Isabelle LemieuxNature200617167477No
224337241241.383.7627.9Multidrug resistance in cancer: role of ATP-dependent transporters. Michael M Gottesman, Tito Fojo, Susan E BatesNat Rev Cancer200211902585No
224412411241.027.1727.2Codon usage and tRNA content in unicellular and multicellular organisms. T IkemuraMol Biol Evol19853916708No
224537231241.081.9127.3A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. R Medzhitov, P Preston-Hurlburt, C A JanewayNature19979237759Yes
224612411241.00.00.0The effective period of preventive antibiotic action in experimental incisions and dermal lesions. J F BurkeSurgery196116722001Yes
224712401240.020.4920.5Antigen receptor tail clue. M RethNature19892927501Yes
224824791239.562.8931.4Inflammation, stress, and diabetes. Kathryn E Wellen, Gökhan S HotamisligilJ Clin Invest200515864338No
224912391239.032.8132.8Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. R M SapolskyArch Gen Psychiatry200011015810No
225037171239.078.6226.2The versatility and universality of calcium signalling. M J Berridge, P Lipp, M D BootmanNat Rev Mol Cell Biol200011413485No
225124751237.573.1836.6Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. J I Morgan, T CurranAnnu Rev Neurosci19911903243No
225212371237.042.4442.4How is the level of free arachidonic acid controlled in mammalian cells? R F IrvineBiochem J19826810878No
225312371237.025.8925.9Searching for genetic determinants in the new millennium. N J RischNature200010866211No
225424731236.556.6928.3Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. D A Brown, J K RoseCell19921531449Yes
225512361236.039.5839.6Ordinary magic. Resilience processes in development. A S MastenAm Psychol200111315249Yes
225624711235.580.4940.2Astrocytes: biology and pathology. Michael V Sofroniew, Harry V VintersActa Neuropathol201020012068No
225712351235.066.8966.9The determinants of parenting: a process model. J BelskyChild Dev19846705636Yes
225812351235.062.3362.3Chronic illness as biographical disruption. M BurySociol Health Illn198210260456Yes
225912351235.039.6239.6Graphene transistors. Frank SchwierzNat Nanotechnol201020512128Yes
226012341234.00.00.0Bee and wasp venoms. E HabermannScience19724113805No
226124681234.087.1143.6The framing of decisions and the psychology of choice. A Tversky, D KahnemanScience19817455683Yes
226212341234.035.4435.4Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. E B HunzikerOsteoarthritis Cartilage200212056848No
226312331233.00.00.0The origin of the genetic code. F H CrickJ Mol Biol19684887876Yes
226412331233.025.8425.8Endocytosis and molecular sorting. I MellmanAnnu Rev Cell Dev Biol19968970738No
226512331233.026.6626.7The many faces of macrophage activation. David M MosserJ Leukoc Biol200312554797No
226612331233.046.1346.1Matching methods for causal inference: A review and a look forward. Elizabeth A StuartStat Sci201020871802Yes
226724651232.545.8722.9Rab proteins as membrane organizers. M Zerial, H McBrideNat Rev Mol Cell Biol200111252952No
226824641232.090.8145.4The stunned myocardium: prolonged, postischemic ventricular dysfunction. E Braunwald, R A KlonerCirculation19826754130No
226924641232.052.1626.1Short-term synaptic plasticity. Robert S Zucker, Wade G RegehrAnnu Rev Physiol200211826273No
227012321232.00.00.0On the local reactions of the arterial wall to changes of internal pressure. W M BaylissJ Physiol190216992618Yes
227112321232.047.8147.8Functional and effective connectivity: a review. Karl J FristonBrain Connect201122432952No
227261581231.6151.030.2Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L CoffmanJ Immunol19862419430Yes
227312311231.038.8438.8Strong localization of photons in certain disordered dielectric superlattices. JohnPhys Rev Lett198710034761Yes
227412311231.035.3635.4Synergy, antagonism, and what the chequerboard puts between them. F C OddsJ Antimicrob Chemother200312805255No
227524611230.593.1546.6Universal chemical assay for the detection and determination of siderophores. B Schwyn, J B NeilandsAnal Biochem19872952030Yes
227624611230.557.5128.8Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Joshua E Elias, Steven P GygiNat Methods200717327847Yes
227724611230.574.3637.2The Measurement Of Selection On Correlated Characters. Russell Lande, Stevan J ArnoldEvolution198328556011Yes
227849201230.0147.9537.0Reversible middle cerebral artery occlusion without craniectomy in rats. E Z Longa, P R Weinstein, S Carlson, R CumminsStroke19892643202Yes
227912301230.023.1123.1c-Myc target genes involved in cell growth, apoptosis, and metabolism. C V DangMol Cell Biol19999858526No
228024601230.00.00.0Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. G J Todaro, H GreenJ Cell Biol196313985244Yes
228112301230.045.6545.6Phase retrieval algorithms: a comparison. J R FienupAppl Opt198220396114Yes
228224591229.552.126.1The molecular biology of axon guidance. M Tessier-Lavigne, C S GoodmanScience19968895455No
228324591229.574.0937.0Molecular mechanisms of long noncoding RNAs. Kevin C Wang, Howard Y ChangMol Cell201121925379No
228412291229.024.9524.9STATs: signal transducers and activators of transcription. J N IhleCell19968608586No
228512281228.045.0545.0The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. A RaineSchizophr Bull19911805349Yes
228612281228.00.00.0Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. P RakicJ Comp Neurol19714101340Yes
228724561228.063.9432.0Long short-term memory. S Hochreiter, J SchmidhuberNeural Comput19979377276Yes
228812281228.027.3927.4HIF-1: mediator of physiological and pathophysiological responses to hypoxia. G L SemenzaJ Appl Physiol (1985)200010749844No
228912281228.039.1139.1Understanding organofluorine chemistry. An introduction to the C-F bond. David O'HaganChem Soc Rev200818197347No
229012271227.033.9433.9Understanding biofilm resistance to antibacterial agents. David DaviesNat Rev Drug Discov200312563302No
229124511225.547.9324.0Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. C Li, W H WongProc Natl Acad Sci U S A200111134512Yes
229212251225.034.7534.8Tumor angiogenesis. J FolkmanAdv Cancer Res19852581424No
229361241224.8191.7338.3Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E WaltersArch Gen Psychiatry200515939839Yes
229473481224.7203.2433.9Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur WheelerN Engl J Med200010793162Yes
229524491224.565.0332.5Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. M P Lutolf, J A HubbellNat Biotechnol200515637621No
2296110191224.3353.9639.3The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C DunbarJ Clin Psychiatry19989881538No
229712241224.00.00.0A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. A M OlovnikovJ Theor Biol19734754905Yes
229812241224.039.2739.3A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Ozcan ErelClin Biochem200415003729Yes
229912241224.037.6337.6Treatment of infections associated with surgical implants. Rabih O DarouicheN Engl J Med200415070792No
230012241224.029.6529.6Refined structure of the nicotinic acetylcholine receptor at 4A resolution. Nigel UnwinJ Mol Biol200515701510Yes
230112241224.057.4157.4KDIGO clinical practice guidelines for acute kidney injury. Arif KhwajaNephron Clin Pract201222890468No
230212231223.00.00.0Disconnexion syndromes in animals and man. I. N GeschwindBrain19655318481No
230312231223.036.436.4Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. P WillnerPsychopharmacology (Berl)19979452163No
230412231223.00.00.0Observations on the isolated phrenic nerve diaphragm preparation of the rat. E BulbringBr J Pharmacol Chemother194620999334Yes
230512221222.037.4937.5Calcium channel modulation by neurotransmitters, enzymes and drugs. H ReuterNature19836131381No
230612221222.022.4222.4Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. H E RuleyNature19836308473Yes
230724431221.555.427.7LTP and LTD: an embarrassment of riches. Robert C Malenka, Mark F BearNeuron200415450156No
230824431221.558.3529.2Cellular senescence: when bad things happen to good cells. Judith Campisi, Fabrizio d'Adda di FagagnaNat Rev Mol Cell Biol200717667954No
230912211221.030.5330.5The 'effective number of codons' used in a gene. F WrightGene19902110097Yes
231012211221.00.00.0Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. P O SeglenExp Cell Res19734358115Yes
231112211221.030.8230.8Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. J DeisenhoferBiochemistry19817236608Yes
231236611220.3144.648.2CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Teresa C Horan, Mary Andrus, Margaret A DudeckAm J Infect Control200818538699No
231336611220.3137.3245.8Global estimates of the prevalence of diabetes for 2010 and 2030. J E Shaw, R A Sicree, P Z ZimmetDiabetes Res Clin Pract201019896746Yes
231436611220.3112.5937.5I-TASSER: a unified platform for automated protein structure and function prediction. Ambrish Roy, Alper Kucukural, Yang ZhangNat Protoc201020360767Yes
231524401220.00.00.0Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. G K McMaster, G G CarmichaelProc Natl Acad Sci U S A197773185Yes
231661001220.0235.3947.1Evidence based medicine: what it is and what it isn't. D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S RichardsonBMJ19968555924No
231712201220.040.5940.6An application of prefrontal cortex function theory to cognitive aging. R L WestPsychol Bull19968831298No
231812201220.030.2430.2Proinflammatory cytokines. C A DinarelloChest200010936147No
231912201220.032.7832.8Clinical features of metastatic bone disease and risk of skeletal morbidity. Robert E ColemanClin Cancer Res200617062708No
232024391219.562.4131.2Interneurons of the hippocampus. T F Freund, G BuzsákiHippocampus19968915675No
232124381219.061.9531.0Pharmacology and functions of metabotropic glutamate receptors. P J Conn, J P PinAnnu Rev Pharmacol Toxicol19979131252No
232212191219.042.6942.7Stress and disorders of the stress system. George P ChrousosNat Rev Endocrinol200919488073No
232324371218.549.3624.7Prediction of complete gene structures in human genomic DNA. C Burge, S KarlinJ Mol Biol19979149143Yes
232436521217.3167.7955.9In search of how people change. Applications to addictive behaviors. J O Prochaska, C C DiClemente, J C NorcrossAm Psychol19921329589Yes
232512171217.047.447.4Asthma phenotypes: the evolution from clinical to molecular approaches. Sally E WenzelNat Med201222561835No
232612161216.00.00.0A restriction point for control of normal animal cell proliferation. A B PardeeProc Natl Acad Sci U S A19744524638Yes
232760801216.00.00.0Transection of the oesophagus for bleeding oesophageal varices. R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R WilliamsBr J Surg19734541913Yes
232824321216.063.1731.6Genetic dissection of complex traits. E S Lander, N J SchorkScience19948091226No
232912161216.00.00.0On the psychophysical law. S S StevensPsychol Rev195713441853Yes
233012151215.00.00.0The intraclass correlation coefficient as a measure of reliability. J J BartkoPsychol Rep19665942109Yes
233112151215.037.0337.0Circuitry and functional aspects of the insular lobe in primates including humans. J R AugustineBrain Res Brain Res Rev19968957561No
233224301215.079.9140.0Porosity of 3D biomaterial scaffolds and osteogenesis. Vassilis Karageorgiou, David KaplanBiomaterials200515860204No
233348591214.8169.4842.4clusterProfiler: an R package for comparing biological themes among gene clusters. Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu HeOMICS201222455463Yes
233424281214.00.00.0High resolution acrylamide gel electrophoresis of histones. S Panyim, R ChalkleyArch Biochem Biophys19695778650Yes
233512141214.060.3360.3Whatever next? Predictive brains, situated agents, and the future of cognitive science. Andy ClarkBehav Brain Sci201323663408No
233624271213.561.0130.5Molecular mechanisms of action of steroid/thyroid receptor superfamily members. M J Tsai, B W O'MalleyAnnu Rev Biochem19947979245No
233712131213.038.0838.1Classification of chronic viral hepatitis: a need for reassessment. P J ScheuerJ Hepatol19911808228No
233812131213.027.0627.1Heterotrimeric G proteins: organizers of transmembrane signals. E J NeerCell19957834744No
233912131213.031.4431.4Rapid evolution of a protein in vitro by DNA shuffling. W P StemmerNature19948047147Yes
234012131213.034.2534.2Diversity of group types, regulation, and function of phospholipase A2. E A DennisJ Biol Chem19948175726No
234112131213.024.6624.7Cytokines induce the development of functionally heterogeneous T helper cell subsets. A O'GarraImmunity19989529145No
234224261213.063.8431.9The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Clay B Holroyd, Michael G H ColesPsychol Rev200212374324Yes
234312131213.00.00.0The critical incident technique. J C FlanaganPsychol Bull195413177800Yes
234412121212.034.0134.0Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. F HeftiJ Neurosci19863746405Yes
234512121212.031.0131.0Endothelial-leukocyte adhesion molecules. M P BevilacquaAnnu Rev Immunol19938476577No
234612121212.027.0927.1Maintenance of C. elegans. Theresa StiernagleWormBook200618050451No
234712121212.054.5854.6Cognitive reserve in ageing and Alzheimer's disease. Yaakov SternLancet Neurol201223079557No
234812111211.031.1931.2The mitochondrial electron transport and oxidative phosphorylation system. Y HatefiAnnu Rev Biochem19852862839No
234924211210.50.00.0Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. H A Edmondson, P E SteinerCancer195413160935Yes
235012101210.042.8342.8The theoretical bases of indirect calorimetry: a review. E FerranniniMetabolism19883278194No
235112101210.00.00.0The biologic clock: the mitochondria? D HarmanJ Am Geriatr Soc19725016631Yes
235224191209.588.4344.2Total energy intake: implications for epidemiologic analyses. W Willett, M J StampferAm J Epidemiol19863521261No
235324181209.067.5433.8Nitric oxide synthases: roles, tolls, and controls. C Nathan, Q W XieCell19947522969No
235412091209.00.00.0Diversity in tropical rain forests and coral reefs. J H ConnellScience197817840770Yes
235524171208.574.5537.3Epidemiology of invasive candidiasis: a persistent public health problem. M A Pfaller, D J DiekemaClin Microbiol Rev200717223626No
235624161208.039.3619.7A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. D Tautz, C PfeifleChromosoma19892476281Yes
235712071207.046.4846.5The structure of beta-lactamases. R P AmblerPhilos Trans R Soc Lond B Biol Sci19806109327Yes
235812071207.035.3235.3Peptide antibiotics and their role in innate immunity. H G BomanAnnu Rev Immunol19957612236No
235912061206.038.2438.2Linkage map of Escherichia coli K-12, edition 7. B J BachmannMicrobiol Rev19836348505No
236060281205.6193.2738.7Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. J S Beckman, T W Beckman, J Chen, P A Marshall, B A FreemanProc Natl Acad Sci U S A19902154753Yes
236112051205.026.1526.1Antigen-presenting function of the macrophage. E R UnanueAnnu Rev Immunol19846242349No
236212051205.028.7828.8Oxyradicals and DNA damage. L J MarnettCarcinogenesis200010688856No
236312051205.029.5829.6Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? Rui WangFASEB J200212409322Yes
236412051205.040.8240.8The law of attrition. Gunther EysenbachJ Med Internet Res200515829473Yes
236524101205.065.332.6The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Daniel J Drucker, Michael A NauckLancet200617098089No
236624091204.546.0923.0Live or let die: the cell's response to p53. Karen H Vousden, Xin LuNat Rev Cancer200212154352No
236736131204.397.4832.5Cognitive and emotional influences in anterior cingulate cortex. Bush, Luu, PosnerTrends Cogn Sci200010827444Yes
236812041204.029.8329.8Bcl-2 initiates a new category of oncogenes: regulators of cell death. S J KorsmeyerBlood19921498330No
236912041204.055.4255.4Continuous improvement as an ideal in health care. D M BerwickN Engl J Med19892909878Yes
237012041204.036.4236.4The origins of the developmental origins theory. D J P BarkerJ Intern Med200717444880No
237112041204.030.8330.8Fast and robust fixed-point algorithms for independent component analysis. A HyvärinenIEEE Trans Neural Netw199918252563Yes
237272231203.8274.8145.8TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L SalzbergGenome Biol201323618408Yes
237348131203.2143.2635.8Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Weidner, J P Semple, W R Welch, J FolkmanN Engl J Med19911701519Yes
237412031203.059.3759.4New norms of upper limb fat and muscle areas for assessment of nutritional status. A R FrisanchoAm J Clin Nutr19816975564Yes
237512031203.021.4921.5The economics of ribosome biosynthesis in yeast. J R WarnerTrends Biochem Sci199910542411No
237612031203.033.7333.7Genetic consequences of climatic oscillations in the Quaternary. G M HewittPhilos Trans R Soc Lond B Biol Sci200415101575No
2377132271202.5380.1134.6The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J RoccellaJAMA200312748199No
237824051202.5169.3984.7Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. Ivica Letunic, Peer BorkNucleic Acids Res201627095192Yes
237912021202.026.3526.4Dendritic cells: unique leukocyte populations which control the primary immune response. D N HartBlood19979345009No
238024041202.051.8625.9Regulated portals of entry into the cell. Sean D Conner, Sandra L SchmidNature200312621426No
238124041202.00.00.0The Aggregation Of Blood Platelets. G V Born, M J CrossJ Physiol196314056485Yes
238260091201.8156.3731.3Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory CollinsLancet200212493255Yes
238324031201.574.4937.2An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Sun Ho Kim, Jin Mo ChungPain19921333581Yes
238424031201.595.647.8Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Jennifer A Doudna, Emmanuelle CharpentierScience201425430774No
238524021201.00.00.0Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. J M Tanner, R H WhitehouseArch Dis Child1976952550Yes
238612011201.00.00.0Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. W D HamiltonScience19676021675Yes
238736031201.086.5428.8Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. Christian W Tornøe, Caspar Christensen, Morten MeldalJ Org Chem200211975567Yes
238812011201.022.6822.7SUMO: a history of modification. Ronald T HayMol Cell200515808504No
238924021201.059.229.6Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Jane E Visvader, Geoffrey J LindemanNat Rev Cancer200818784658No
239024011200.561.1230.6The DNA damage response: making it safe to play with knives. Alberto Ciccia, Stephen J ElledgeMol Cell201020965415No
239136001200.0110.3936.8Oxidants, antioxidants, and the degenerative diseases of aging. B N Ames, M K Shigenaga, T M HagenProc Natl Acad Sci U S A19938367443No
239212001200.039.0739.1The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. J L CummingsNeurology19979153155No
239312001200.027.827.8Physiological and molecular basis of thyroid hormone action. P M YenPhysiol Rev200111427693No
239412001200.00.00.0The anterior approach for removal of ruptured cervical disks. R B ClowardJ Neurosurg195813599052Yes
239512001200.00.00.0Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. J M Van RossumArch Int Pharmacodyn Ther196313996119Yes
239612001200.034.8934.9Polycystic ovary syndrome. David A EhrmannN Engl J Med200515788499No
239723991199.578.9939.5Oxidative mechanisms in the toxicity of metal ions. S J Stohs, D BagchiFree Radic Biol Med19957744317No
239823991199.571.635.8The gut microbiota shapes intestinal immune responses during health and disease. June L Round, Sarkis K MazmanianNat Rev Immunol200919343057No
239911991199.025.2625.3MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. R N GermainCell19948293464No
240023981199.068.4134.2Bronchopulmonary dysplasia. A H Jobe, E BancalariAm J Respir Crit Care Med200111401896No
240111991199.028.3828.4Topoisomerase I inhibitors: camptothecins and beyond. Yves PommierNat Rev Cancer200616990856No
240223981199.064.5632.3Powering the planet: chemical challenges in solar energy utilization. Nathan S Lewis, Daniel G NoceraProc Natl Acad Sci U S A200617043226Yes
240323961198.0112.9556.5Natural products as sources of new drugs over the 30 years from 1981 to 2010. David J Newman, Gordon M CraggJ Nat Prod201222316239No
240411981198.043.3843.4Aging, cellular senescence, and cancer. Judith CampisiAnnu Rev Physiol201323140366No
240523951197.571.435.7Regulation of chromatin by histone modifications. Andrew J Bannister, Tony KouzaridesCell Res201121321607No
240623951197.577.2138.6Genome regulation by long noncoding RNAs. John L Rinn, Howard Y ChangAnnu Rev Biochem201222663078No
240711971197.035.2535.2Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Arnold I CaplanJ Cell Physiol200717620285No
240835891196.3129.3143.1A new method for off-line removal of ocular artifact. G Gratton, M G Coles, E DonchinElectroencephalogr Clin Neurophysiol19836187540Yes
240911961196.032.5232.5Low density lipoprotein oxidation and its pathobiological significance. D SteinbergJ Biol Chem19979261091No
241011961196.036.3336.3Invasive aspergillosis. D W DenningClin Infect Dis19989564455No
241135881196.063.9921.3A system for stable expression of short interfering RNAs in mammalian cells. Thijn R Brummelkamp, René Bernards, Reuven AgamiScience200211910072Yes
241211961196.024.3224.3Mechanisms of caspase activation and inhibition during apoptosis. Yigong ShiMol Cell200211931755No
241323921196.055.2927.6Escaping free-energy minima. Alessandro Laio, Michele ParrinelloProc Natl Acad Sci U S A200212271136Yes
2414131541195.8331.3130.1New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G GwytherJ Natl Cancer Inst200010655437No
241535871195.7112.737.6A rapid bootstrap algorithm for the RAxML Web servers. Alexandros Stamatakis, Paul Hoover, Jacques RougemontSyst Biol200818853362Yes
241623911195.561.5530.8The free radical theory of aging matures. K B Beckman, B N AmesPhysiol Rev19989562038No
241711951195.036.3636.4Qinghaosu (artemisinin): an antimalarial drug from China. D L KlaymanScience19853887571No
241811951195.027.1827.2Hybridization of denatured RNA transferred or dotted nitrocellulose paper. P S ThomasMethods Enzymol19836194404Yes
241923901195.070.1435.1Molecular replacement with MOLREP. Alexei Vagin, Alexei TeplyakovActa Crystallogr D Biol Crystallogr201020057045Yes
242023891194.50.00.0Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. J E Sulston, H R HorvitzDev Biol1977838129Yes
242123891194.543.9122.0The DNA damage response: putting checkpoints in perspective. B B Zhou, S J ElledgeNature200011100718No
242211941194.028.4528.4Growth factors and cancer. S A AaronsonScience19911659742No
242311941194.029.7929.8Hereditary cancer, oncogenes, and antioncogenes. A G KnudsonCancer Res19852983882Yes
242411941194.041.5141.5Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. Chao-Jun LiAcc Chem Res200919220064Yes
242523871193.546.8323.4CpG islands in vertebrate genomes. M Gardiner-Garden, M FrommerJ Mol Biol19873656447Yes
242611931193.059.1259.1ROC methodology in radiologic imaging. C E MetzInvest Radiol19863095258No
242711931193.033.4633.5Diagnosis of osteoporosis and assessment of fracture risk. John A KanisLancet200212057569No
242811931193.032.832.8Marine viruses--major players in the global ecosystem. Curtis A SuttleNat Rev Microbiol200717853907No
242911931193.041.1541.1Signal transduction by reactive oxygen species. Toren FinkelJ Cell Biol201121746850No
243011921192.048.748.7Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. E H BeacheyJ Infect Dis19817014727No
243123841192.064.3232.2A globally coherent fingerprint of climate change impacts across natural systems. Camille Parmesan, Gary YoheNature200312511946Yes
243223831191.547.3823.7Checkpoints: controls that ensure the order of cell cycle events. L H Hartwell, T A WeinertScience19892683079No
243323831191.568.4134.2What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? K C Berridge, T E RobinsonBrain Res Brain Res Rev19989858756No
243411911191.032.832.8The human orbitofrontal cortex: linking reward to hedonic experience. Morten L KringelbachNat Rev Neurosci200516136173No
243511911191.028.9629.0Mechanisms of foxp3+ T regulatory cell-mediated suppression. Ethan M ShevachImmunity200919464986No
243611891189.045.5945.6UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. D W RussellJ Pers Assess19968576833Yes
243723781189.061.430.7Rising incidence of hepatocellular carcinoma in the United States. H B El-Serag, A C MasonN Engl J Med199910072408Yes
243811891189.00.00.0The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. G A RoseBull World Health Organ196213974778Yes
243911881188.023.7223.7microRNAs: tiny regulators with great potential. V AmbrosCell200111779458No
244011881188.032.932.9Reconciling the chemistry and biology of reactive oxygen species. Christine C WinterbournNat Chem Biol200818421291No
244123751187.561.9531.0Neuronal plasticity: increasing the gain in pain. C J Woolf, M W SalterScience200010846153No
244223751187.554.1427.1The pathophysiology of mitochondrial cell death. Douglas R Green, Guido KroemerScience200415286356No
244311871187.00.00.0Campylobacter enteritis: a "new" disease. M B SkirrowBr Med J1977871765Yes
244423741187.00.00.0Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. J D Peuler, G A JohnsonLife Sci1977904439Yes
244511871187.00.00.0Assay of intestinal disaccharidases. A DahlqvistAnal Biochem19685636962Yes
244611871187.00.00.0Studies on phosphatidylcholine vesicles. Formation and physical characteristics. C HuangBiochemistry19695777332Yes
244723741187.064.3132.2Leukocyte-endothelial adhesion molecules. T M Carlos, J M HarlanBlood19947522621No
244811871187.026.2626.3The finer things in X-ray diffraction data collection. J W PflugrathActa Crystallogr D Biol Crystallogr199910531521Yes
244911871187.027.327.3The stem-cell niche as an entity of action. David T ScaddenNature200616810242No
245023731186.575.1937.6CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. Mattias Jakobsson, Noah A RosenbergBioinformatics200717485429Yes
245123731186.565.2832.6Cell signaling by receptor tyrosine kinases. Mark A Lemmon, Joseph SchlessingerCell201020602996No
245235591186.388.7229.6Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Witold Filipowicz, Suvendra N Bhattacharyya, Nahum SonenbergNat Rev Genet200818197166No
245323721186.079.5139.8Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. Johan W S Vlaeyen, Steven J LintonPain200010781906No
245411861186.040.0740.1Chlorophyll fluorescence: a probe of photosynthesis in vivo. Neil R BakerAnnu Rev Plant Biol200818444897No
245511851185.047.1347.1Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. T Florian JaegerJ Mem Lang200819884961Yes
245647361184.0217.5354.4Bayesian phylogenetics with BEAUti and the BEAST 1.7. Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew RambautMol Biol Evol201222367748Yes
245723681184.067.6733.8The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. W L Jorgensen, J Tirado-RivesJ Am Chem Soc198827557051Yes
245811831183.045.2845.3Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. S H SafeCrit Rev Toxicol19948037844No
245911831183.029.4229.4Somatostatin and its receptor family. Y C PatelFront Neuroendocrinol199910433861No
246011831183.029.1729.2Reactive oxygen radicals in signaling and damage in the ischemic brain. P H ChanJ Cereb Blood Flow Metab200111149664No
246123651182.554.727.4Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. T Hunter, B M SeftonProc Natl Acad Sci U S A19806246487Yes
246247301182.5113.1728.3Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J ThunN Engl J Med200312711737Yes
246311821182.028.7528.8Intracellular protein topogenesis. G BlobelProc Natl Acad Sci U S A19806929499Yes
246411821182.00.00.0The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma. W G DuncombeClin Chim Acta196414122498Yes
246523631181.50.00.0Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Altman, G D DasJ Comp Neurol19655861717Yes
246623631181.545.222.6DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Christopher J Bakkenist, Michael B KastanNature200312556884Yes
246711811181.043.3943.4Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. R M PostAm J Psychiatry19921353322No
246811811181.00.00.0The cytoarchitectonic organization of the spinal cord in the cat. B RexedJ Comp Neurol195214946260Yes
246982631180.4346.0349.4Development and validation of a geriatric depression screening scale: a preliminary report. J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O LeirerJ Psychiatr Res19827183759Yes
247023601180.00.00.0Surgical risk as related to time of intervention in the repair of intracranial aneurysms. W E Hunt, R M HessJ Neurosurg19685635959Yes
247123601180.064.0632.0Nanostructures in biodiagnostics. Nathaniel L Rosi, Chad A MirkinChem Rev200515826019No
247223601180.094.2347.1The integrative review: updated methodology. Robin Whittemore, Kathleen KnaflJ Adv Nurs200516268861Yes
247335371179.091.5130.5Long non-coding RNAs: insights into functions. Tim R Mercer, Marcel E Dinger, John S MattickNat Rev Genet200919188922No
247411781178.038.038.0The pathogenesis of sepsis. R C BoneAnn Intern Med19911872494No
247523561178.00.00.0Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine. R W Butcher, E W SutherlandJ Biol Chem196213875173Yes
247611781178.038.4538.5Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Thomas GrobnerNephrol Dial Transplant200616431890Yes
247723551177.564.832.4Therapeutic potential of resveratrol: the in vivo evidence. Joseph A Baur, David A SinclairNat Rev Drug Discov200616732220No
247823551177.575.6537.8The cortical organization of speech processing. Gregory Hickok, David PoeppelNat Rev Neurosci200717431404No
247911771177.025.2725.3Caspase structure, proteolytic substrates, and function during apoptotic cell death. D W NicholsonCell Death Differ199910578171No
248023541177.049.1824.6Gene silencing in cancer in association with promoter hypermethylation. James G Herman, Stephen B BaylinN Engl J Med200314627790No
248111771177.034.5134.5Stress and depression. Constance HammenAnnu Rev Clin Psychol200517716090No
2482164701176.4365.6226.1Crystallography & NMR system: A new software suite for macromolecular structure determination. A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L WarrenActa Crystallogr D Biol Crystallogr19989757107Yes
248370541175.7185.8131.0A default mode of brain function. M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L ShulmanProc Natl Acad Sci U S A200111209064Yes
248411751175.034.9535.0Atopic dermatitis. Thomas BieberN Engl J Med200818385500Yes
248511741174.030.5230.5Surrogate endpoints in clinical trials: definition and operational criteria. R L PrenticeStat Med19892727467Yes
248611741174.039.7939.8Interleukin-1 and the pathogenesis of the acute-phase response. C A DinarelloN Engl J Med19846208485No
248735221174.088.5329.5Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Christopher R Genovese, Nicole A Lazar, Thomas NicholsNeuroimage200211906227Yes
248823481174.073.4536.7Mediation in experimental and nonexperimental studies: new procedures and recommendations. Patrick E Shrout, Niall BolgerPsychol Methods200212530702Yes
248911741174.034.0834.1The cancer stem cell: premises, promises and challenges. Hans CleversNat Med201121386835No
249011741174.045.6945.7Inflammation in atherosclerosis. Peter LibbyArterioscler Thromb Vasc Biol201222895665No
249123471173.556.8528.4Peroxisome proliferator-activated receptors: nuclear control of metabolism. B Desvergne, W WahliEndocr Rev199910529898No
249211731173.029.8929.9The neuropathology of schizophrenia. A critical review of the data and their interpretation. P J HarrisonBrain199910219775No
249323461173.082.3641.2Oxidative stress and diabetic complications. Ferdinando Giacco, Michael BrownleeCirc Res201021030723No
249411721172.055.955.9A cognitive approach to panic. D M ClarkBehav Res Ther19863741311Yes
249511721172.00.00.0Displaced proximal humeral fractures. I. Classification and evaluation. C S NeerJ Bone Joint Surg Am19705455339Yes
249611721172.024.5524.6Morphogenetic roles of classic cadherins. M TakeichiCurr Opin Cell Biol19958573335No
249723441172.045.5722.8The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. T Maehama, J E DixonJ Biol Chem19989593664Yes
249811721172.00.00.0A sensitive method for the assay of 5-hydroxytryptamine. J R VaneBr J Pharmacol Chemother195713460242Yes
249911711171.00.00.0A chemical method for the determination of oestriol, oestrone and oestradiol in human urine. J B BrownBiochem J195514389222Yes
250011711171.00.00.0Histological demonstration of mucin after periodic acid. J F A McMANUSNature194620995486Yes
250111701170.021.2221.2Cancer susceptibility and the functions of BRCA1 and BRCA2. Ashok R VenkitaramanCell200211832208No
250211701170.00.00.0A new readability yardstick. R FleschJ Appl Psychol194818867058Yes
250323391169.574.137.0Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. D Filmer, L H PritchettDemography200111227840Yes
250411691169.00.00.0Nontuberculous mycobacteria and associated diseases. E WolinskyAm Rev Respir Dis1979369415No
250511691169.036.1736.2The mysteries of lipoprotein(a). G UtermannScience19892530631No
250611691169.040.8140.8The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. N M KaplanArch Intern Med19892662932No
250711691169.065.8765.9Psychosocial resilience and protective mechanisms. Michael RutterAm J Orthopsychiatry19873303954No
250835071169.085.0328.3Dystrophin: the protein product of the Duchenne muscular dystrophy locus. E P Hoffman, R H Brown, L M KunkelCell19873319190Yes
250911691169.034.8234.8Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. W SieghartPharmacol Rev19957568326No
251023371168.5119.0359.5A new initiative on precision medicine. Francis S Collins, Harold VarmusN Engl J Med201525635347Yes
251111681168.036.7136.7Biosynthesis and metabolism of endothelium-derived nitric oxide. L J IgnarroAnnu Rev Pharmacol Toxicol19902188578No
251211681168.026.0126.0The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. S J CollinsBlood19873311197No
251311681168.031.3431.3Drug delivery and targeting. R LangerNature19989579855No
251411681168.028.928.9The path to ubiquitous and low-cost organic electronic appliances on plastic. Stephen R ForrestNature200415118718Yes
251535021167.3102.5334.2Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. H King, R E Aubert, W H HermanDiabetes Care19989727886Yes
251611671167.037.5737.6Antioxidants in human health and disease. B HalliwellAnnu Rev Nutr19968839918No
251735011167.074.1424.7Large-scale analysis of the yeast proteome by multidimensional protein identification technology. M P Washburn, D Wolters, J R YatesNat Biotechnol200111231557Yes
251811671167.032.4532.5Plasmonics: merging photonics and electronics at nanoscale dimensions. Ekmel OzbayScience200616410515Yes
251911671167.036.4536.5Multiple imputation of discrete and continuous data by fully conditional specification. Stef van BuurenStat Methods Med Res200717621469Yes
252011671167.033.0233.0Microbial influences in inflammatory bowel diseases. R Balfour SartorGastroenterology200818242222No
252123331166.568.6234.3Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Robert E W Hancock, Hans-Georg SahlNat Biotechnol200617160061No
252234991166.386.1828.7Global and societal implications of the diabetes epidemic. P Zimmet, K G Alberti, J ShawNature200111742409No
252311661166.00.00.0Measurement of feelings using visual analogue scales. R C AitkenProc R Soc Med19694899510No
252411661166.042.4442.4Multimodal approach to control postoperative pathophysiology and rehabilitation. H KehletBr J Anaesth19979175983No
252511661166.052.9753.0MorphoJ: an integrated software package for geometric morphometrics. Christian Peter KlingenbergMol Ecol Resour201121429143Yes
2526104911165.7357.7639.8A novel potent vasoconstrictor peptide produced by vascular endothelial cells. M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T MasakiNature19882451132Yes
252734971165.786.6628.9Functional diversity of helper T lymphocytes. A K Abbas, K M Murphy, A SherNature19968893001No
252834961165.30.00.0Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. A DeLean, P J Munson, D RodbardAm J Physiol1978686171Yes
252923301165.00.00.0The low-density lipoprotein pathway and its relation to atherosclerosis. J L Goldstein, M S BrownAnnu Rev Biochem1977197883No
253011651165.044.544.5A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. S T TiffanyPsychol Rev19902186423No
253158221164.4191.7738.4Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L WitztumN Engl J Med19892648148No
253223281164.0122.2561.1A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. M Roland, R MorrisSpine (Phila Pa 1976)19836222486Yes
253311641164.029.0829.1Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. P KuzmicAnal Biochem19968660575Yes
253411641164.021.9922.0Kinesin and dynein superfamily proteins and the mechanism of organelle transport. N HirokawaScience19989438838No
253511641164.026.5726.6S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. R DonatoInt J Biochem Cell Biol200111390274No
253623281164.074.0937.0The benefits of being present: mindfulness and its role in psychological well-being. Kirk Warren Brown, Richard M RyanJ Pers Soc Psychol200312703651Yes
253711641164.028.4328.4Oxidative stress in neurodegeneration: cause or consequence? Julie K AndersenNat Med200415298006No
253811631163.00.00.0Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation. M M WeiserJ Biol Chem19734698230Yes
253911631163.052.6152.6Presynaptic regulation of the release of catecholamines. S Z LangerPharmacol Rev19806267618Yes
254011631163.021.7421.7The molecular motor toolbox for intracellular transport. Ronald D ValeCell200312600311No
254111621162.026.3926.4Prediction of protein cellular attributes using pseudo-amino acid composition. K C ChouProteins200111288174Yes
254234851161.7105.4135.1The functional anatomy of basal ganglia disorders. R L Albin, A B Young, J B PenneyTrends Neurosci19892479133No
254323231161.595.0247.5Rapid procedure for detection and isolation of large and small plasmids. C I Kado, S T LiuJ Bacteriol19817009583Yes
254423231161.586.6543.3How useful is SBF in predicting in vivo bone bioactivity? Tadashi Kokubo, Hiroaki TakadamaBiomaterials200616448693No
254534841161.30.00.0Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. A L Shapiro, E Viñuela, J V MaizelBiochem Biophys Res Commun19674861258Yes
254646451161.2110.0227.5A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry SharplessAngew Chem Int Ed Engl200212203546Yes
254711611161.049.3749.4Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). S SafeCrit Rev Toxicol19902124811No
254811611161.026.926.9Nuclear factor-kappaB: the enemy within. Bharat B AggarwalCancer Cell200415380510No
254923221161.0187.8993.9Natural Products as Sources of New Drugs from 1981 to 2014. David J Newman, Gordon M CraggJ Nat Prod201626852623No
255023211160.563.7131.9Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. M A Pfeffer, E BraunwaldCirculation19902138525No
255123211160.563.9932.0A review of central 5-HT receptors and their function. N M Barnes, T SharpNeuropharmacology199910462127No
255211601160.061.7461.7Rating scales to assess depression in school-aged children. M KovacsActa Paedopsychiatr19817025571Yes
255311601160.019.7619.8Themes and variations on ubiquitylation. A M WeissmanNat Rev Mol Cell Biol200111265246No
255411601160.00.00.0Diffusion-in-gel methods for immunological analysis. II. O OuchterlonyProg Allergy196214482809Yes
255534781159.3121.8440.6Factor structure of the Barratt impulsiveness scale. J H Patton, M S Stanford, E S BarrattJ Clin Psychol19958778124Yes
255611591159.00.00.0Mutation selection and the natural history of cancer. J CairnsNature19751143315Yes
255711591159.074.3674.4Impingement lesions. C S NeerClin Orthop Relat Res19836825348Yes
255811591159.027.4827.5Transcriptional control of adipocyte formation. Stephen R FarmerCell Metab200617011499No
255911581158.00.00.0Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J O HolloszyJ Biol Chem19674290225Yes
256011581158.023.0723.1Mobile elements: drivers of genome evolution. Haig H KazazianScience200415016989No
256111581158.030.0930.1The blood-brain barrier: bottleneck in brain drug development. William M PardridgeNeuroRx200515717053No
256269451157.5178.4529.7GROMACS: fast, flexible, and free. David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C BerendsenJ Comput Chem200516211538Yes
256311571157.022.1122.1Contingent genetic regulatory events in T lymphocyte activation. G R CrabtreeScience19892783497Yes
256411571157.00.00.0Presynaptic regulation of catecholamine release. S Z LangerBiochem Pharmacol19744617579No
256511571157.036.2436.2Depression in late life: review and commentary. Dan G BlazerJ Gerontol A Biol Sci Med Sci200312634292No
256634711157.090.6730.2Functional porous coordination polymers. Susumu Kitagawa, Ryo Kitaura, Shin-ichiro NoroAngew Chem Int Ed Engl200415114565Yes
256711571157.00.00.0An approximate distribution of estimates of variance components. F E SatterthwaiteBiometrics194620287815Yes
256823131156.550.5325.3ERBB receptors and cancer: the complexity of targeted inhibitors. Nancy E Hynes, Heidi A LaneNat Rev Cancer200515864276No
256957821156.4787.15157.4MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro TamuraMol Biol Evol201829722887Yes
257011561156.052.5452.5Human agency in social cognitive theory. A BanduraAm Psychol19892782727Yes
257111561156.022.5122.5Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Ricky W JohnstoneNat Rev Drug Discov200212120280No
257211561156.033.2333.2Emotion regulation: affective, cognitive, and social consequences. James J GrossPsychophysiology200212212647No
257311561156.037.0537.0Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). Gunther EysenbachJ Med Internet Res200415471760No
257492441155.5242.6930.3Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M JoliotNeuroimage200211771995Yes
257546211155.299.4124.9Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. D D Sarbassov, David A Guertin, Siraj M Ali, David M SabatiniScience200515718470Yes
257634631154.372.5624.2Cellular survival: a play in three Akts. S R Datta, A Brunet, M E GreenbergGenes Dev199910579998No
257711541154.00.00.0RNA metabolism in the HeLa cell nucleus. S PenmanJ Mol Biol19665961144Yes
257869221153.7136.0722.7Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T TuschlNature200111373684Yes
257923071153.50.00.0Plasminogen: purification from human plasma by affinity chromatography. D G Deutsch, E T MertzScience19705475635Yes
258011531153.045.2145.2Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes. H V GelboinPhysiol Rev19807001511No
258111531153.027.7327.7Liver fibrosis -- from bench to bedside. Scott L FriedmanJ Hepatol200312591185No
258234561152.00.00.0High resolution two-dimensional electrophoresis of basic as well as acidic proteins. P Z O'Farrell, H M Goodman, P H O'FarrellCell197723215Yes
258311521152.046.946.9An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. J Kabat-ZinnGen Hosp Psychiatry19827042457Yes
258423031151.50.00.0Quantitative determination of serum triglycerides by the use of enzymes. G Bucolo, H DavidClin Chem19734703655Yes
258523031151.559.5229.8Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Kornelia Polyak, Robert A WeinbergNat Rev Cancer200919262571No
258623021151.045.3322.7Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. C W Greider, E H BlackburnCell19853907856Yes
258711511151.040.9440.9Inhibition and facilitation of nucleic acid amplification. I G WilsonAppl Environ Microbiol19979327537No
258811511151.060.9761.0Optical properties of biological tissues: a review. Steven L JacquesPhys Med Biol201323666068No
258911511151.057.4457.4Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement. Virginia A MoyerAnn Intern Med201424378917No
259011501150.053.9854.0Biomaterial-centered infection: microbial adhesion versus tissue integration. A G GristinaScience19873629258Yes
259134501150.00.00.0The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. G Blessed, B E Tomlinson, M RothBr J Psychiatry19685662937Yes
259211501150.00.00.0Selective coronary arteriography. I. A percutaneous transfemoral technic. M P JudkinsRadiology19676048074Yes
259323001150.051.4225.7Lymphocyte homing and homeostasis. E C Butcher, L J PickerScience19968600538No
259422991149.562.9131.5Imaging cognition II: An empirical review of 275 PET and fMRI studies. R Cabeza, L NybergJ Cogn Neurosci200010769304No
259534481149.396.4432.1Molecular characterization of a peripheral receptor for cannabinoids. S Munro, K L Thomas, M Abu-ShaarNature19937689702Yes
259611491149.028.1328.1Matrix proteoglycans: from molecular design to cellular function. R V IozzoAnnu Rev Biochem19989759499No
259711491149.033.8533.9Varieties of impulsivity. J L EvendenPsychopharmacology (Berl)199910550486No
259822981149.047.6923.8Molecular chaperones in the cytosol: from nascent chain to folded protein. F Ulrich Hartl, Manajit Hayer-HartlScience200211884745No
259911491149.033.3633.4The sympathetic control of blood pressure. Patrice G GuyenetNat Rev Neurosci200616760914No
260011491149.00.00.0A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations. R D HotchkissArch Biochem194818921848Yes
260111481148.025.8925.9Cadherins: a molecular family important in selective cell-cell adhesion. M TakeichiAnnu Rev Biochem19902197976No
260211481148.030.6730.7Pathogenesis of dengue: challenges to molecular biology. S B HalsteadScience19883277268No
260311481148.031.1431.1The lipocalin protein family: structure and function. D R FlowerBiochem J19968761444No
260411481148.023.4123.4Lipid rafts: elusive or illusive? Sean MunroCell200314622593No
260511481148.026.6826.7Long-term potentiation and memory. M A LynchPhysiol Rev200414715912No
260657371147.4111.8222.4Crystal structure of the nucleosome core particle at 2.8 A resolution. K Luger, A W Mäder, R K Richmond, D F Sargent, T J RichmondNature19979305837Yes
260711471147.053.4253.4Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. P de LevaJ Biomech19968872282Yes
260811471147.030.1430.1Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. G BodenDiabetes19978971073No
260922941147.065.4532.7Antibiotic resistance of bacteria in biofilms. P S Stewart, J W CostertonLancet200111463434No
261022941147.050.1125.1Tumorigenesis and the angiogenic switch. Gabriele Bergers, Laura E BenjaminNat Rev Cancer200312778130No
261111461146.058.9859.0The clinical application of the biopsychosocial model. G L EngelAm J Psychiatry19807369396Yes
261211461146.027.8927.9DNA damage, aging, and cancer. Jan H J HoeijmakersN Engl J Med200919812404No
261334361145.3116.3238.8Simultaneous inference in general parametric models. Torsten Hothorn, Frank Bretz, Peter WestfallBiom J200818481363No
261411451145.00.00.0Radioimmunological determination of human C-peptide in serum. L G HedingDiabetologia19751239396Yes
261511451145.00.00.0Biogenic amines and the states of sleep. M JouvetScience19694303225No
261611441144.00.00.0Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. D B ClewellJ Bacteriol19724336693Yes
261722881144.063.9332.0ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. Markus Wiederstein, Manfred J SipplNucleic Acids Res200717517781Yes
261822871143.50.00.0Growth of a rat neuroblastoma cell line in serum-free supplemented medium. J E Bottenstein, G H SatoProc Natl Acad Sci U S A1979284369Yes
261934301143.375.025.0Calcium signalling: dynamics, homeostasis and remodelling. Michael J Berridge, Martin D Bootman, H Llewelyn RoderickNat Rev Mol Cell Biol200312838335No
262022861143.069.7634.9Recent advances in the phencyclidine model of schizophrenia. D C Javitt, S R ZukinAm J Psychiatry19911654746No
262111431143.021.021.0Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. D HanahanNature19852986015Yes
262211431143.032.3332.3DNA topoisomerases. M GellertAnnu Rev Biochem19816267993No
262311431143.029.2929.3Optimal experimental design for event-related fMRI. A M DaleHum Brain Mapp199910524601Yes
262422851142.561.4530.7Regulation mechanisms and signaling pathways of autophagy. Congcong He, Daniel J KlionskyAnnu Rev Genet200919653858No
262522841142.00.00.0Solubilization of membranes by detergents. A Helenius, K SimonsBiochim Biophys Acta19751091302No
262611421142.033.4333.4Papillary and follicular thyroid carcinoma. M J SchlumbergerN Engl J Med19989445411No
262734231141.00.00.0Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. G M Wahl, M Stern, G R StarkProc Natl Acad Sci U S A1979291033Yes
262822821141.046.6623.3A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. N C Andrews, D V FallerNucleic Acids Res19912041787Yes
262922821141.062.6631.3Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. R A Ignotz, J MassaguéJ Biol Chem19863456347Yes
263011401140.00.00.0Experience from a multicentre stroke register: a preliminary report. S HatanoBull World Health Organ19761088404Yes
263111401140.00.00.0pA, a new scale for the measurement of drug antagonism. H O SchildBr J Pharmacol Chemother194720258355Yes
263211391139.030.6930.7Psychological and neural mechanisms of the affective dimension of pain. D D PriceScience200010846154No
263311391139.025.025.0Platelets in atherothrombosis. Zaverio M RuggeriNat Med200212411949No
263411381138.035.7935.8Protein damage and degradation by oxygen radicals. I. general aspects. K J DaviesJ Biol Chem19873036875Yes
263511381138.031.6131.6Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. U MitzdorfPhysiol Rev19853880898No
263611381138.045.1745.2Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. S KatzJ Am Geriatr Soc19836418786No
263711381138.00.00.0Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. R J PenningtonBiochem J196113734134Yes
263822761138.054.3627.2Can the pharmaceutical industry reduce attrition rates? Ismail Kola, John LandisNat Rev Drug Discov200415286737No
263934131137.787.9729.3LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. A C Wallace, R A Laskowski, J M ThorntonProtein Eng19957630882Yes
264022751137.50.00.0Radiological demarcation of cemented sockets in total hip replacement. J G DeLee, J CharnleyClin Orthop Relat Res1976991504Yes
264134121137.30.00.0Cytochemical identification of monocytes and granulocytes. L T Yam, C Y Li, W H CrosbyAm J Clin Pathol19715549896Yes
264211371137.00.00.0Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. S Z LangerBr J Pharmacol197720190No
264311371137.027.6727.7Rapid and sensitive sequence comparison with FASTP and FASTA. W R PearsonMethods Enzymol19902156132Yes
264411371137.028.9528.9Two distinct classes of carbohydrate-recognition domains in animal lectins. K DrickamerJ Biol Chem19883290208No
264511371137.00.00.0The concept of immunological surveillance. F M BurnetProg Exp Tumor Res19704921480No
264611371137.00.00.0Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells. A B StavitskyJ Immunol195413163409Yes
264711371137.00.00.0A simple objective technique for measuring flexibility in thinking. E A BergJ Gen Psychol194818889466Yes
264834101136.793.3831.1Membrane lipids: where they are and how they behave. Gerrit van Meer, Dennis R Voelker, Gerald W FeigensonNat Rev Mol Cell Biol200818216768No
264968181136.3175.2729.2Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O LötvallNat Cell Biol200717486113Yes
265022721136.089.0844.5Malondialdehyde determination as index of lipid peroxidation. H H Draper, M HadleyMethods Enzymol19902233309Yes
265111361136.034.4134.4Effect of anoxia on ion distribution in the brain. A J HansenPhysiol Rev19853880896No
265211361136.00.00.0Pathologic anatomy of the pancreas in juvenile diabetes mellitus. W GeptsDiabetes19655318831Yes
265311361136.00.00.0An improved fluorometric assay for DNA. R T HinegardnerAnal Biochem19715544593Yes
265411361136.054.0954.1Selenium and human health. Margaret P RaymanLancet201222381456No
265534061135.389.4629.8Atomic force microscope. Binnig, Quate, GerberPhys Rev Lett198610033323Yes
265622691134.560.8130.4Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Uwe-Karsten Hanisch, Helmut KettenmannNat Neurosci200717965659No
265722681134.049.7324.9Functions of lipid rafts in biological membranes. D A Brown, E LondonAnnu Rev Cell Dev Biol19989891780No
265811341134.026.8326.8Mitochondrial transport of cations: channels, exchangers, and permeability transition. P BernardiPhysiol Rev199910508231No
265945361134.0100.3325.1Interleukin-10 and the interleukin-10 receptor. K W Moore, R de Waal Malefyt, R L Coffman, A O'GarraAnnu Rev Immunol200111244051No
266011341134.029.0229.0Primate anterior cingulate cortex: where motor control, drive and cognition interface. T PausNat Rev Neurosci200111389475No
266111341134.038.1138.1The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Artemis P SimopoulosExp Biol Med (Maywood)200818408140No
266222671133.595.8547.9Reading senseless sentences: brain potentials reflect semantic incongruity. M Kutas, S A HillyardScience19807350657Yes
266322661133.071.4335.7Role of oxidized low density lipoprotein in atherogenesis. J L Witztum, D SteinbergJ Clin Invest19911752940No
266411331133.00.00.0Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone. A R MidgleyEndocrinology19665950482Yes
266511331133.036.9637.0Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. J J GrossJ Pers Soc Psychol19989457784Yes
266611331133.026.4526.4Diarylethenes for Memories and Switches. Masahiro IrieChem Rev200011777416Yes
266711331133.027.8927.9Pathways of oxidative damage. James A ImlayAnnu Rev Microbiol200314527285No
266811331133.027.3227.3The Unified Medical Language System (UMLS): integrating biomedical terminology. Olivier BodenreiderNucleic Acids Res200414681409Yes
266922651132.564.832.4Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Ajay Kumar Gupta, Mona GuptaBiomaterials200515626447No
267022641132.061.8330.9Myocardial reperfusion injury. Derek M Yellon, Derek J HausenloyN Engl J Med200717855673No
267111311131.052.5352.5Derivation and validation of a short-form oral health impact profile. G D SladeCommunity Dent Oral Epidemiol19979332805Yes
267211311131.022.3922.4Mechanisms and consequences of activation of protein kinase B/Akt. J DownwardCurr Opin Cell Biol19989561851No
267311311131.026.1126.1Translating cell biology into therapeutic advances in Alzheimer's disease. D J SelkoeNature199910392577No
267422611130.548.4824.2A general framework for weighted gene co-expression network analysis. Bin Zhang, Steve HorvathStat Appl Genet Mol Biol200516646834Yes
267533911130.379.9226.6OrthoMCL: identification of ortholog groups for eukaryotic genomes. Li Li, Christian J Stoeckert, David S RoosGenome Res200312952885Yes
267611301130.043.4343.4On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. D CollenThromb Haemost19806450468No
267733891129.774.9225.0Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Michael J Rust, Mark Bates, Xiaowei ZhuangNat Methods200616896339Yes
267822591129.559.1229.6Drug delivery systems: entering the mainstream. Theresa M Allen, Pieter R CullisScience200415031496Yes
267911291129.031.9131.9The biochemistry and medical significance of the flavonoids. Bent H HavsteenPharmacol Ther200212453566No
268011281128.019.6919.7Mitotic kinases as regulators of cell division and its checkpoints. E A NiggNat Rev Mol Cell Biol200111413462No
268122541127.0155.8177.9Facial nerve grading system. J W House, D E BrackmannOtolaryngol Head Neck Surg19853921901Yes
268211271127.020.5820.6Stem cells: units of development, units of regeneration, and units in evolution. I L WeissmanCell200010647940No
268311271127.025.3225.3The roles of intracellular protein-degradation pathways in neurodegeneration. David C RubinszteinNature200617051204No
268411271127.028.8228.8Huntington's disease. Francis O WalkerLancet200717240289No
268533801126.768.8723.0Predicting coiled coils from protein sequences. A Lupas, M Van Dyke, J StockScience19912031185Yes
268633801126.790.630.2Wnt/beta-catenin signaling: components, mechanisms, and diseases. Bryan T MacDonald, Keiko Tamai, Xi HeDev Cell200919619488No
268711261126.035.5635.6Chronic disease management: what will it take to improve care for chronic illness? E H WagnerEff Clin Pract199810345255No
268811261126.026.8626.9Brain tumors. L M DeAngelisN Engl J Med200111150363No
268911261126.025.6825.7Molecular physiology of low-voltage-activated t-type calcium channels. Edward Perez-ReyesPhysiol Rev200312506128No
269045021125.5112.3528.1Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. H Nielsen, J Engelbrecht, S Brunak, G von HeijneProtein Eng19979051728Yes
269111251125.033.8333.8Unstable angina. A classification. E BraunwaldCirculation19892752565Yes
269211251125.024.5224.5Stem cells in the central nervous system. R McKayScience19979082987No
269311241124.028.8828.9Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. I J FidlerCancer Res19901698118Yes
269422471123.50.00.0Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases. L M Siegel, K J MontyBiochim Biophys Acta19665329026Yes
269522471123.548.4224.2Toll-like receptors in the induction of the innate immune response. A Aderem, R J UlevitchNature200010963608No
269633701123.3101.4933.8Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Günter Oberdörster, Eva Oberdörster, Jan OberdörsterEnviron Health Perspect200516002369No
269711231123.036.3836.4Molecular biology of steroid hormone synthesis. W L MillerEndocr Rev19883061784No
269811231123.030.3230.3The chromosomal basis of human neoplasia. J J YunisScience19836336310Yes
269911231123.022.4822.5Regulation of transcription by MAP kinase cascades. R TreismanCurr Opin Cell Biol19968791420No
270011231123.034.8534.9Low-molecular-weight heparins. J I WeitzN Engl J Med19979278467No
270122451122.50.00.0Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. R B Gustilo, J T AndersonJ Bone Joint Surg Am1976773941Yes
270222441122.044.0122.0Multiple nuclear factors interact with the immunoglobulin enhancer sequences. R Sen, D BaltimoreCell19863091258Yes
270311221122.023.3323.3IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Yong-Jun LiuAnnu Rev Immunol200515771572No
270422441122.059.5829.8Microenvironmental regulation of metastasis. Johanna A Joyce, Jeffrey W PollardNat Rev Cancer200919279573No
270511221122.037.8637.9Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Charles A DinarelloBlood201121304099No
270633651121.785.128.4Tissue cells feel and respond to the stiffness of their substrate. Dennis E Discher, Paul Janmey, Yu-Li WangScience200516293750No
270722431121.561.1330.6Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. M J Casadaban, S N CohenJ Mol Biol19806997493Yes
270822421121.065.8832.9Increasing incidence of thyroid cancer in the United States, 1973-2002. Louise Davies, H Gilbert WelchJAMA200616684987Yes
270922411120.50.00.0Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. J D McGhee, P H von HippelJ Mol Biol19744416620Yes
271022411120.50.00.0Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. H H Ussing, K ZerahnActa Physiol Scand195114868510Yes
271122411120.596.8848.4Van der Waals heterostructures. A K Geim, I V GrigorievaNature201323887427Yes
271211201120.078.3578.3The problem of rigor in qualitative research. M SandelowskiANS Adv Nurs Sci19863083765Yes
271311201120.033.833.8Determinants of tumor blood flow: a review. R K JainCancer Res19883282647No
271411201120.040.8340.8Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. W A CatterallAnnu Rev Pharmacol Toxicol19806247957No
271511201120.026.7926.8Amyloid, the presenilins and Alzheimer's disease. J HardyTrends Neurosci19979106355No
271611201120.00.00.0On the law of effect. R J HerrnsteinJ Exp Anal Behav197016811440Yes
271722391119.575.8237.9Atomic structure and chemistry of human serum albumin. X M He, D C CarterNature19921630489Yes
271822391119.566.1733.1Excitatory amino acids as a final common pathway for neurologic disorders. S A Lipton, P A RosenbergN Engl J Med19947905600No
271911191119.033.0433.0Cell surface interactions with extracellular materials. K M YamadaAnnu Rev Biochem19836351729No
272011191119.031.9932.0The induction of pain: an integrative review. M J MillanProg Neurobiol19999987804No
272111191119.040.7740.8Plasma perspective on strong field multiphoton ionization. CorkumPhys Rev Lett199310054556Yes
272211191119.032.2332.2How brains beware: neural mechanisms of emotional attention. Patrik VuilleumierTrends Cogn Sci200516289871Yes
272344741118.5108.3827.1Base-calling of automated sequencer traces using phred. I. Accuracy assessment. B Ewing, L Hillier, M C Wendl, P GreenGenome Res19989521921Yes
272411181118.00.00.0An approach for the treatment of penile carcinoma. R M CabanasCancer1977837331Yes
272522361118.091.4245.7The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. R Näätänen, T PictonPsychophysiology19873615753Yes
272611181118.044.0544.0Translating social ecological theory into guidelines for community health promotion. D StokolsAm J Health Promot199610159709No
272711181118.028.7828.8Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science. Christof M NiemeyerAngew Chem Int Ed Engl200129712109No
272844711117.8132.0133.0Place navigation impaired in rats with hippocampal lesions. R G Morris, P Garrud, J N Rawlins, J O'KeefeNature19827088155Yes
272933531117.772.3224.1Toll-like receptors: critical proteins linking innate and acquired immunity. S Akira, K Takeda, T KaishoNat Immunol200111477402No
273022351117.550.8425.4The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. P M Sharp, W H LiNucleic Acids Res19873547335Yes
273111171117.00.00.0Optimal foraging, the marginal value theorem. E L CharnovTheor Popul Biol19761273796Yes
273211171117.030.530.5Pain and emotion interactions in subregions of the cingulate gyrus. Brent A VogtNat Rev Neurosci200515995724No
273311171117.00.00.0The generalisation of student's problems when several different population variances are involved. B L WelchBiometrika194720287819Yes
2734178661116.6681.4642.6Fiji: an open-source platform for biological-image analysis. Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert CardonaNat Methods201222743772Yes
273544661116.5105.2826.3SCOP: a structural classification of proteins database for the investigation of sequences and structures. A G Murzin, S E Brenner, T Hubbard, C ChothiaJ Mol Biol19957723011Yes
273611161116.023.8823.9Mutator phenotype may be required for multistage carcinogenesis. L A LoebCancer Res19912039987No
273711161116.036.9136.9Endometriosis. Serdar E BulunN Engl J Med200919144942No
273844601115.0101.5625.4Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. J E Walker, M Saraste, M J Runswick, N J GayEMBO J19826329717Yes
273922301115.077.8238.9Quality control and preprocessing of metagenomic datasets. Robert Schmieder, Robert EdwardsBioinformatics201121278185Yes
274022291114.563.3831.7Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. R G Phillips, J E LeDouxBehav Neurosci19921590953Yes
274111141114.030.930.9Diseases of the mitochondrial DNA. D C WallaceAnnu Rev Biochem19921497308No
274211141114.039.4239.4Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. A J AlpertJ Chromatogr19902324207Yes
274311141114.026.6326.6Allelic discrimination using fluorogenic probes and the 5' nuclease assay. K J LivakGenet Anal199910084106Yes
274411141114.031.1531.1Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Earl S FordDiabetes Care200515983333No
274533421114.099.4133.1Nitric oxide and peroxynitrite in health and disease. Pál Pacher, Joseph S Beckman, Lucas LiaudetPhysiol Rev200717237348No
274633411113.787.2629.1Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. C R Woese, O Kandler, M L WheelisProc Natl Acad Sci U S A19902112744Yes
274733411113.7124.6241.5Rehospitalizations among patients in the Medicare fee-for-service program. Stephen F Jencks, Mark V Williams, Eric A ColemanN Engl J Med200919339721Yes
274811131113.027.0727.1Metastatic bone disease: clinical features, pathophysiology and treatment strategies. R E ColemanCancer Treat Rev200111417967No
274911121112.00.00.0Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J AltmanJ Comp Neurol19695361244Yes
275011121112.033.6733.7Reducing children's television viewing to prevent obesity: a randomized controlled trial. T N RobinsonJAMA199910546696Yes
275111121112.025.6825.7Gene finding in novel genomes. Ian KorfBMC Bioinformatics200415144565Yes
275211121112.030.7530.8Polymer conjugates as anticancer nanomedicines. Ruth DuncanNat Rev Cancer200616900224No
275322231111.566.6633.3Nitric oxide synthases in mammals. R G Knowles, S MoncadaBiochem J19947510950No
275422231111.50.00.0Construct validity in psychological tests. L J Cronbach, P E MeehlPsychol Bull195513245896Yes
275511111111.033.9934.0The structure of common mental disorders. R F KruegerArch Gen Psychiatry199910530634Yes
275611101110.00.00.0Cytoprotection by prostaglandins. A RobertGastroenterology197938173Yes
275711101110.028.9428.9Linkage strategies for genetically complex traits. I. Multilocus models. N RischAm J Hum Genet19902301392Yes
275811101110.00.00.0Studies on histones. 7. Preparative methods for histone fractions from calf thymus. E W JohnsBiochem J19645840387Yes
275944381109.5123.6730.9Microbial ecology: human gut microbes associated with obesity. Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I GordonNature200617183309Yes
276022191109.565.7732.9Alternative activation of macrophages: mechanism and functions. Siamon Gordon, Fernando O MartinezImmunity201020510870No
276133281109.368.9223.0The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Fabio Martinon, Kimberly Burns, Jürg TschoppMol Cell200212191486Yes
276211091109.021.1821.2Luciferase reporter gene vectors for analysis of promoters and enhancers. S K NordeenBiotechniques19882908509Yes
276311091109.00.00.06-Hydroxy-dopamine induced degeneration of central monoamine neurons. U UngerstedtEur J Pharmacol19685718510Yes
276422181109.00.00.0Micromethod for the direct determination of serum triglycerides. E Van Handel, D B ZilversmitJ Lab Clin Med195713439279Yes
276533271109.078.2426.1Hepatocellular carcinoma. Josep M Llovet, Andrew Burroughs, Jordi BruixLancet200314667750No
276611091109.025.2725.3Solving structures of protein complexes by molecular replacement with Phaser. Airlie J McCoyActa Crystallogr D Biol Crystallogr200717164524Yes
276722171108.50.00.0A revision of the Schoenheimer-Sperry method for cholesterol determination. W M Sperry, M WebbJ Biol Chem195014794694Yes
276822171108.561.8230.9Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Barry J Everitt, Trevor W RobbinsNat Neurosci200516251991No
276922161108.061.1430.6Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. S Schulman, C KearonJ Thromb Haemost200515842354Yes
277011071107.00.00.0Metabolic stability and epigenesis in randomly constructed genetic nets. S A KauffmanJ Theor Biol19695803332Yes
277111071107.023.4323.4Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. Harold F DvorakJ Clin Oncol200212409337No
277233191106.3106.8835.6Dose translation from animal to human studies revisited. Shannon Reagan-Shaw, Minakshi Nihal, Nihal AhmadFASEB J200817942826Yes
277311061106.00.00.0Structure of chromatin. R D KornbergAnnu Rev Biochem1977332067No
277411061106.034.7934.8Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. E N BergmanPhysiol Rev19902181501No
277511061106.025.3825.4Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. M KozakNucleic Acids Res19817301588Yes
277622121106.044.3222.2NF-kappaB at the crossroads of life and death. Michael Karin, Anning LinNat Immunol200211875461No
277711061106.036.1736.2Risk and maintenance factors for eating pathology: a meta-analytic review. Eric SticePsychol Bull200212206196No
277811061106.00.00.0The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis. R E Hope-SimpsonProc R Soc Med196514267505Yes
277911051105.035.5235.5Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J E OesterlingJ Urol19911707989No
278022101105.049.2124.6Prediction of protein secondary structure at better than 70% accuracy. B Rost, C SanderJ Mol Biol19938345525Yes
278122091104.50.00.0Microdroplet Assay Of Human Serum Cytotoxins. P I Terasaki, J D McclellandNature196414248725Yes
278222081104.048.1324.1Atherosclerosis. the road ahead. C K Glass, J L WitztumCell200111239408No
278322081104.050.9225.5Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Eugenia E Calle, Rudolf KaaksNat Rev Cancer200415286738No
278422081104.062.3531.2Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. Gerard Talavera, Jose CastresanaSyst Biol200717654362Yes
278511041104.031.2331.2Plant productivity and environment. J S BoyerScience198217808529Yes
278622071103.543.821.9Homeobox genes and axial patterning. W McGinnis, R KrumlaufCell19921346368No
278722061103.041.1920.6Stats: transcriptional control and biological impact. David E Levy, J E DarnellNat Rev Mol Cell Biol200212209125No
278811031103.00.00.0Preliminary Trial Of Carisoprodol In Multiple Sclerosis. B AshworthPractitioner196414143329Yes
278911031103.026.7526.8Production of recombinant protein therapeutics in cultivated mammalian cells. Florian M WurmNat Biotechnol200415529164No
279011031103.035.4935.5Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. Felix KratzJ Control Release200818582981No
279111031103.031.1331.1Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. G L SemenzaOncogene201019946328No
279211021102.040.0140.0The LMS method for constructing normalized growth standards. T J ColeEur J Clin Nutr19902354692Yes
279311021102.037.6737.7Chemoprevention of cancer. L W WattenbergCancer Res19853880665No
279411021102.023.5723.6ALSCRIPT: a tool to format multiple sequence alignments. G J BartonProtein Eng19938433969Yes
279511021102.00.00.0Voluntary strength and fatigue. P A MertonJ Physiol195413152698Yes
279622041102.052.1326.1Toll-like receptors in innate immunity. Kiyoshi Takeda, Shizuo AkiraInt Immunol200515585605No
279711021102.025.4925.5Neuroligins and neurexins link synaptic function to cognitive disease. Thomas C SüdhofNature200818923512No
279811011101.00.00.0Knee joint changes after meniscectomy. T J FairbankJ Bone Joint Surg Br194818894618Yes
279911001100.00.00.0Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units. C M VenkatachalamBiopolymers19685685102Yes
280011001100.043.3643.4Molecular aspects of ligand binding to serum albumin. U Kragh-HansenPharmacol Rev19817027277No
280111001100.00.00.0The powerful placebo. H K BeecherJ Am Med Assoc195513271123Yes
280211001100.00.00.0Inherited Antithrombin Deficiency Causing Thrombophilia. O EgebergThromb Diath Haemorrh196514347873Yes
280311001100.030.4330.4Hydrogen sulphide and its therapeutic potential. Csaba SzabóNat Rev Drug Discov200717948022No
280421991099.5140.7570.4A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. E S Grood, W J SuntayJ Biomech Eng19836865355Yes
280532981099.30.00.0Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. M Hamberg, J Svensson, B SamuelssonProc Natl Acad Sci U S A19751059088Yes
280665951099.2178.6529.8Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat RoblesBioinformatics200516081474Yes
280710991099.025.0325.0Microglia as a source and target of cytokines. Uwe-Karsten HanischGlia200212379902No
280810991099.021.9922.0Microarray data normalization and transformation. John QuackenbushNat Genet200212454644No
280910991099.036.8336.8Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Ronald A HitesEnviron Sci Technol200414998004Yes
281021971098.545.622.8Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. G A Gonzalez, M R MontminyCell19892573431Yes
281121971098.50.00.0Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. R J Britten, D E KohneScience19684874239Yes
281221971098.50.00.0Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. A H Coons, M H KaplanJ Exp Med195015395569Yes
281310981098.031.0831.1Normalization of cell responses in cat striate cortex. D J HeegerVis Neurosci19921504027Yes
281410981098.00.00.0The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion. S RosemanChem Phys Lipids19705476326Yes
2815120741097.6438.9339.9A new equation to estimate glomerular filtration rate. Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef CoreshAnn Intern Med200919414839Yes
281610971097.023.0623.1Differentiation and proliferation of hematopoietic stem cells. M OgawaBlood19938499622No
281710971097.00.00.0A cytoarchitectonic atlas of the spinal cord in the cat. B RexedJ Comp Neurol195413163236Yes
281810971097.029.8629.9Wound healing and its impairment in the diabetic foot. Vincent FalangaLancet200516291068No
281921931096.50.00.0Construction of phylogenetic trees. W M Fitch, E MargoliashScience19675334057No
282021921096.072.4136.2Excitatory amino acid transmitters. J C Watkins, R H EvansAnnu Rev Pharmacol Toxicol19816112965No
282110961096.037.2437.2High density lipoprotein metabolism. S EisenbergJ Lipid Res19846392459No
282210961096.026.4826.5The prefrontal cortex and cognitive control. E K MillerNat Rev Neurosci200011252769No
282310961096.030.8230.8Neural simulation of action: a unifying mechanism for motor cognition. M JeannerodNeuroimage200111373140No
282410961096.034.7734.8Cytokinesis-block micronucleus cytome assay. Michael FenechNat Protoc200717546000Yes
282510951095.0103.95104.0The analysis of errors in orthodontic measurements. W J HoustonAm J Orthod19836573846Yes
282610951095.024.7324.7The molecular biology of leukocyte chemoattractant receptors. P M MurphyAnnu Rev Immunol19948011292No
282710951095.030.8830.9Leishmaniasis. B L HerwaldtLancet199910513726No
282810951095.027.5227.5Metabolism and functions of glutathione in brain. R DringenProg Neurobiol200010880854No
282943801095.0121.2430.3Prevalence and trends in obesity among US adults, 1999-2000. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L JohnsonJAMA200212365955Yes
283010951095.030.3830.4Q-ball imaging. David S TuchMagn Reson Med200415562495Yes
283121891094.550.2625.1Adaptive protein evolution at the Adh locus in Drosophila. J H McDonald, M KreitmanNature19911904993Yes
283265671094.5229.4538.2The occurrence of sleep-disordered breathing among middle-aged adults. T Young, M Palta, J Dempsey, J Skatrud, S Weber, S BadrN Engl J Med19938464434Yes
283310941094.00.00.0Sex-hormone-binding globulin. D C AndersonClin Endocrinol (Oxf)19744134992No
283410941094.037.437.4Selective attention and the organization of visual information. J DuncanJ Exp Psychol Gen19846240521Yes
283510941094.024.6824.7Physiological concentrations of purines and pyrimidines. T W TrautMol Cell Biochem19947877593No
283610941094.025.5825.6Neurobiology of Pavlovian fear conditioning. S MarenAnnu Rev Neurosci200111520922No
283721881094.064.3432.2The cognitive control of emotion. Kevin N Ochsner, James J GrossTrends Cogn Sci200515866151No
283821881094.070.3535.2Natural products as sources of new drugs over the last 25 years. David J Newman, Gordon M CraggJ Nat Prod200717309302No
283976561093.7160.3822.9Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P SpeedBiostatistics200312925520Yes
284021871093.567.2733.6A cognitive model of posttraumatic stress disorder. A Ehlers, D M ClarkBehav Res Ther200010761279No
284110931093.022.3422.3Primary response genes induced by growth factors and tumor promoters. H R HerschmanAnnu Rev Biochem19911883198No
284221861093.063.4731.7Meeting of minds: the medial frontal cortex and social cognition. David M Amodio, Chris D FrithNat Rev Neurosci200616552413No
284310931093.00.00.0Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins. R D OwenScience194517755278Yes
284410931093.025.725.7Recognition and processing of ubiquitin-protein conjugates by the proteasome. Daniel FinleyAnnu Rev Biochem200919489727No
284521861093.091.0845.5Neutrophil recruitment and function in health and inflammation. Elzbieta Kolaczkowska, Paul KubesNat Rev Immunol201323435331No
284610921092.029.0729.1Neural systems for recognizing emotion. Ralph AdolphsCurr Opin Neurobiol200212015233No
284721821091.096.0248.0Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. P R Hunter, M A GastonJ Clin Microbiol19883069867Yes
284810911091.041.9942.0The role of endothelium in the responses of vascular smooth muscle to drugs. R F FurchgottAnnu Rev Pharmacol Toxicol19846203480No
284910911091.00.00.0Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. R M BerneAm J Physiol196313971060Yes
285010911091.034.1234.1High prevalence of vitamin D inadequacy and implications for health. Michael F HolickMayo Clin Proc200616529140No
285110901090.039.439.4Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. J N WasserheitSex Transm Dis19921595015No
285210901090.030.8230.8Internal models for motor control and trajectory planning. M KawatoCurr Opin Neurobiol199910607637No
285310901090.023.3523.4Basement membranes: structure, assembly and role in tumour angiogenesis. Raghu KalluriNat Rev Cancer200312778132No
285421801090.072.236.1An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. O Johnell, J A KanisOsteoporos Int200616983459Yes
285510891089.041.4141.4Omega-3 fatty acids in health and disease and in growth and development. A P SimopoulosAm J Clin Nutr19911908631No
285610891089.023.0923.1A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. J MilbrandtScience19873672127Yes
285721781089.061.1630.6Epidemiology and outcomes of osteoporotic fractures. Steven R Cummings, L Joseph MeltonLancet200212049882No
285810891089.00.00.0The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. J VagueAm J Clin Nutr195613282851Yes
285910891089.00.00.0The purine and pyrimidine composition of deoxypentose nucleic acids. G R WyattBiochem J195114838906Yes
286010881088.022.9823.0T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. R H SchwartzAnnu Rev Immunol19852415139No
286110881088.056.9456.9Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. Anna Maria CarlssonPain19836602967Yes
286210881088.029.5329.5The neurobiology of stress: from serendipity to clinical relevance. B S McEwenBrain Res200011119695No
286310881088.030.5230.5Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Paul WillnerNeuropsychobiology200516037678No
286421761088.078.7539.4Oncology meets immunology: the cancer-immunity cycle. Daniel S Chen, Ira MellmanImmunity201323890059No
286543501087.5267.5366.9IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies. Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang MinhMol Biol Evol201525371430Yes
286610871087.044.044.0Social phobia. M R LiebowitzMod Probl Pharmacopsychiatry19872885745Yes
286710871087.021.2921.3Regulation of phosphoinositide-specific phospholipase C. S G RheeAnnu Rev Biochem200111395409No
286810871087.036.4136.4Delirium in older persons. Sharon K InouyeN Engl J Med200616540616No
286910871087.00.00.0Intra-sexual selection in Drosophila. A J BatemanHeredity (Edinb)194818103134Yes
287021731086.552.7326.4Emerging roles of caspase-3 in apoptosis. A G Porter, R U JänickeCell Death Differ199910200555No
287110861086.046.0446.0A cochlear frequency-position function for several species--29 years later. D D GreenwoodJ Acoust Soc Am19902373794Yes
287210861086.021.8121.8Cytokine receptor signalling. J N IhleNature19957566171No
287321721086.044.0922.0Proliferation, cell cycle and apoptosis in cancer. G I Evan, K H VousdenNature200111357141No
287432561085.371.924.0A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. M Serrano, G J Hannon, D BeachNature19938259215Yes
287554261085.2189.7237.9Posttraumatic stress disorder in the National Comorbidity Survey. R C Kessler, A Sonnega, E Bromet, M Hughes, C B NelsonArch Gen Psychiatry19957492257Yes
287610851085.00.00.0Corticosteroids and lymphoid cells. H N ClamanN Engl J Med19725043524Yes
287721681084.076.9438.5The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. G P Chrousos, P W GoldJAMA19921538563No
287821671083.5107.0953.5ROS function in redox signaling and oxidative stress. Michael Schieber, Navdeep S ChandelCurr Biol201424845678No
287910831083.045.0145.0Bone "mass" and the "mechanostat": a proposal. H M FrostAnat Rec19873688455Yes
288021661083.040.7120.4Hedgehog signaling in animal development: paradigms and principles. P W Ingham, A P McMahonGenes Dev200111731473No
288121661083.047.7923.9NF-kappaB: linking inflammation and immunity to cancer development and progression. Michael Karin, Florian R GretenNat Rev Immunol200516175180No
288275791082.7284.6140.7GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J SchünemannBMJ200818436948Yes
288310821082.023.0123.0Apoptosis in neurodegenerative disorders. M P MattsonNat Rev Mol Cell Biol200011253364No
288410821082.030.830.8Physiology and pathophysiology of purinergic neurotransmission. Geoffrey BurnstockPhysiol Rev200717429044No
288543251081.2103.7425.9Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. G L Wang, B H Jiang, E A Rue, G L SemenzaProc Natl Acad Sci U S A19957539918Yes
288610811081.040.7840.8The P300 wave of the human event-related potential. T W PictonJ Clin Neurophysiol19921464675No
288721621081.062.5631.3Ageing and Parkinson's disease: substantia nigra regional selectivity. J M Fearnley, A J LeesBrain19911933245Yes
288810811081.00.00.0A kinetic photometric method for serum gamma-glutamyl transpeptidase. G SzaszClin Chem19695773262Yes
288910811081.026.8326.8The sphingomyelin cycle and the second messenger function of ceramide. Y A HannunJ Biol Chem19948106344No
289010811081.00.00.0Aniline hydrogen phthalate as a spraying reagent for chromatography of sugars. S M PartridgeNature194918140444Yes
289110811081.028.7128.7Non-Smad pathways in TGF-beta signaling. Ying E ZhangCell Res200919114990No
289210811081.038.7338.7Breakthrough of the year 2013. Cancer immunotherapy. Jennifer Couzin-FrankelScience201324357284No
289375631080.4254.9836.4AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J OlsonJ Comput Chem200919399780Yes
289410801080.027.7727.8Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. M J BerridgeBiochem J19836309155Yes
289510801080.030.6930.7Pharmacology of cannabinoid CB1 and CB2 receptors. R G PertweePharmacol Ther19979336020No
289610801080.00.00.0The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs. M VogtJ Physiol195413152692Yes
289710801080.028.4328.4Overview of general physiologic features and functions of vitamin D. Hector F DeLucaAm J Clin Nutr200415585789No
289810801080.031.7831.8Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Antoine BecharaNat Neurosci200516251988No
289921601080.062.0331.0A neurotrophic model for stress-related mood disorders. Ronald S Duman, Lisa M MonteggiaBiol Psychiatry200616631126No
290010791079.032.2432.2Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. M J GassonJ Bacteriol19836403500Yes
290110791079.00.00.0The relation of the trail making test to organic brain damage. R M ReitanJ Consult Psychol195513263471Yes
290210791079.00.00.0A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. M G BuonocoreJ Dent Res195513271655Yes
290321581079.047.4123.7The mammalian unfolded protein response. Martin Schröder, Randal J KaufmanAnnu Rev Biochem200515952902No
290421571078.545.8822.9p53: puzzle and paradigm. L J Ko, C PrivesGenes Dev19968654922No
290510781078.00.00.0Cleavage of the haem-protein link by acid methylethylketone. F W TealeBiochim Biophys Acta195913837237Yes
290621541077.081.8540.9Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. H Esterbauer, K H CheesemanMethods Enzymol19902233308Yes
290721541077.043.5421.8RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. M B Shapiro, P SenapathyNucleic Acids Res19873658675Yes
290810771077.034.2434.2The oxidation hypothesis of atherosclerosis. J L WitztumLancet19947916078No
290910771077.00.00.0Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. P B MedawarBr J Exp Pathol194818865105Yes
291010761076.042.042.0A new international staging system for lung cancer. C F MountainChest19863514171No
291110761076.046.2646.3A spreading-activation theory of retrieval in sentence production. G S DellPsychol Rev19863749399Yes
291210761076.00.00.0A teacher rating scale for use in drug studies with children. C K ConnersAm J Psychiatry19694900822Yes
291310761076.00.00.0Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities. F FonnumBiochem J19694982085Yes
291410761076.033.7933.8Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. M E BoutonPsychol Bull19938346330No
291510761076.023.6823.7An overview of epithelio-mesenchymal transformation. E D HayActa Anat (Basel)19958714286No
291610761076.027.5427.5Optical microcavities. Kerry J VahalaNature200312917698Yes
291721511075.50.00.0Peroxidase-labeled antibody. A new method of conjugation. P K Nakane, A KawaoiJ Histochem Cytochem19744443551Yes
291843021075.5110.3227.6Autophagy fights disease through cellular self-digestion. Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J KlionskyNature200818305538No
291921501075.041.5520.8Dynamic instability of microtubule growth. T Mitchison, M KirschnerNature19846504138Yes
292010751075.030.2530.2Venous thrombosis: a multicausal disease. F R RosendaalLancet199910209995No
292121501075.055.0527.5C-reactive protein: a critical update. Mark B Pepys, Gideon M HirschfieldJ Clin Invest200312813013No
292210741074.030.7830.8Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. T FeiziNature19852579340Yes
292310741074.025.8625.9Molecular drive: a cohesive mode of species evolution. G DoverNature19827110332Yes
292410741074.031.5631.6The effects of stressful life events on depression. R C KesslerAnnu Rev Psychol19979046559No
292510741074.022.0622.1A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. Xuemei ChenScience200412893888Yes
292610741074.00.00.0A New Serum Type System In Man--The Lp System. K BergActa Pathol Microbiol Scand196314064818Yes
292710741074.025.6425.6Human natural killer cells. Michael A CaligiuriBlood200818650461No
292810731073.00.00.0Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. K SatohClin Chim Acta1978719890Yes
292910731073.00.00.0Asymptomatic infections of the urinary tract. E H KassTrans Assoc Am Physicians195613380946Yes
293010731073.022.4822.5Inferences, questions and possibilities in Toll-like receptor signalling. Bruce BeutlerNature200415241424No
293110731073.027.3727.4Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. R Balfour SartorNat Clin Pract Gastroenterol Hepatol200616819502No
293221451072.544.6622.3An automated method for finding molecular complexes in large protein interaction networks. Gary D Bader, Christopher W V HogueBMC Bioinformatics200312525261Yes
293310721072.027.5927.6Selectins: interpreters of cell-specific carbohydrate information during inflammation. L A LaskyScience19921439808No
293464321072.0141.7723.6Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. D A Melton, P A Krieg, M R Rebagliati, T Maniatis, K Zinn, M R GreenNucleic Acids Res19846091052Yes
293510721072.020.2720.3The development of neural stem cells. S TempleNature200111689956No
293610721072.033.4733.5Water as an active constituent in cell biology. Philip BallChem Rev200818095715No
293721431071.557.9529.0Oxidative stress, caloric restriction, and aging. R S Sohal, R WeindruchScience19968658196No
293832141071.3104.0234.7MR diffusion tensor spectroscopy and imaging. P J Basser, J Mattiello, D LeBihanBiophys J19948130344Yes
293932141071.3107.5835.9Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. B K Matuszewski, M L Constanzer, C M Chavez-EngAnal Chem200312964746Yes
294010711071.037.7637.8Multiple organ failure. Pathophysiology and potential future therapy. E A DeitchAnn Surg19921503516No
294110711071.030.5230.5Mitochondrial fusion and fission in cell life and death. Benedikt WestermannNat Rev Mol Cell Biol201021102612No
294221411070.552.3926.2Cellular processing of platinum anticancer drugs. Dong Wang, Stephen J LippardNat Rev Drug Discov200515789122No
294321411070.595.9948.0The future of immune checkpoint therapy. Padmanee Sharma, James P AllisonScience201525838373No
294410701070.025.1125.1Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. S H KaufmannCancer Res19892790800Yes
294510701070.032.5632.6A human model of gastric carcinogenesis. P CorreaCancer Res19883288329No
294621401070.066.1333.12,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. A Poland, J C KnutsonAnnu Rev Pharmacol Toxicol19826282188No
294710701070.033.9233.9Strategies of antioxidant defense. H SiesEur J Biochem19937688300No
294821391069.50.00.0Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. A Warshel, M LevittJ Mol Biol1976985660Yes
294921391069.547.523.8Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. T Hunter, J PinesCell19947954824No
295010691069.021.621.6Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. A S BaldwinJ Clin Invest200111160144No
295121371068.568.3834.2Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. S Geman, D GemanIEEE Trans Pattern Anal Mach Intell198422499653Yes
295221361068.00.00.0Binding of soluble form of fibroblast surface protein, fibronectin, to collagen. E Engvall, E RuoslahtiInt J Cancer1977903179Yes
295310681068.032.832.8What is synergy? M C BerenbaumPharmacol Rev19892692037No
295410681068.032.232.2Cholesterol and the cell membrane. P L YeagleBiochim Biophys Acta19853904832No
295521361068.048.2324.1Cell cycle control and cancer. L H Hartwell, M B KastanScience19947997877No
295610681068.023.6323.6PHD: predicting one-dimensional protein structure by profile-based neural networks. B RostMethods Enzymol19968743704Yes
295721361068.00.00.0Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques. P Gold, S O FreedmanJ Exp Med196514270243Yes
295842701067.5154.438.6Guidelines for the process of cross-cultural adaptation of self-report measures. D E Beaton, C Bombardier, F Guillemin, M B FerrazSpine (Phila Pa 1976)200011124735No
295921351067.596.4948.2The M1 and M2 paradigm of macrophage activation: time for reassessment. Fernando O Martinez, Siamon GordonF1000Prime Rep201424669294No
296021351067.594.3447.2Neoantigens in cancer immunotherapy. Ton N Schumacher, Robert D SchreiberScience201525838375No
296121341067.00.00.0T antigen is bound to a host protein in SV40-transformed cells. D P Lane, L V CrawfordNature1979218111Yes
296221341067.068.6134.3Glutamate and the pathophysiology of hypoxic--ischemic brain damage. S M Rothman, J W OlneyAnn Neurol19862421636No
296310671067.029.7829.8Aging, energy, and oxidative stress in neurodegenerative diseases. M F BealAnn Neurol19957668820No
296410671067.036.4836.5Mitochondria and cancer. Douglas C WallaceNat Rev Cancer201223001348No
296542671066.8129.6232.4Toxic potential of materials at the nanolevel. Andre Nel, Tian Xia, Lutz Mädler, Ning LiScience200616456071No
296621321066.074.337.1Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. A E Czeizel, I DudásN Engl J Med19921307234Yes
296710661066.028.5228.5Disorders of iron metabolism. N C AndrewsN Engl J Med199910607817No
296810661066.025.2125.2Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. H J DargieLancet200111356434Yes
296921321066.00.00.0A microcolorimetric method for the determination of inorganic phosphorus. H H Taussky, E ShorrJ Biol Chem195313061491Yes
297021311065.571.5835.8Chronic hepatitis B: update 2009. Anna S F Lok, Brian J McMahonHepatology200919714720Yes
297121311065.573.0436.5Accessories to the crime: functions of cells recruited to the tumor microenvironment. Douglas Hanahan, Lisa M CoussensCancer Cell201222439926No
297210651065.00.00.0Statistical quality control and routine data processing for radioimmunoassays and immunoradiometric assays. D RodbardClin Chem19744370388No
297310651065.037.1337.1beta-Lactamases in laboratory and clinical resistance. D M LivermoreClin Microbiol Rev19958665470No
297431951065.0139.2246.4Multiple imputation using chained equations: Issues and guidance for practice. Ian R White, Patrick Royston, Angela M WoodStat Med201121225900Yes
297521291064.563.7931.9Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. P Brugada, J BrugadaJ Am Coll Cardiol19921309182Yes
297621291064.551.7825.9Quorum sensing in bacteria. M B Miller, B L BasslerAnnu Rev Microbiol200111544353No
297710641064.031.6631.7The fetal and infant origins of adult disease. D J BarkerBMJ19902252919No
297810641064.025.4925.5Neurons with graded response have collective computational properties like those of two-state neurons. J J HopfieldProc Natl Acad Sci U S A19846587342Yes
297910641064.026.7826.8The Trk family of neurotrophin receptors. M BarbacidJ Neurobiol19947852993No
298010641064.025.2625.3Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. Michael J SandersonMol Biol Evol200211752195Yes
298110641064.027.1527.1Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Hiroshi TakayanagiNat Rev Immunol200717380158No
298231911063.70.00.0Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. M Jondal, G Holm, H WigzellJ Exp Med19724114496Yes
298310631063.00.00.0Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. P StastnyN Engl J Med1978147420Yes
298410631063.024.3224.3The inducible transcription activator NF-kappa B: regulation by distinct protein subunits. P A BaeuerleBiochim Biophys Acta19912018779No
298510631063.043.643.6Freezing of living cells: mechanisms and implications. P MazurAm J Physiol19846383068No
298653151063.0114.2622.9The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. J W Harper, G R Adami, N Wei, K Keyomarsi, S J ElledgeCell19938242751Yes
298710631063.019.3319.3Regulatory T cells in autoimmmunity*. E M ShevachAnnu Rev Immunol200010837065No
298810631063.029.629.6Functionalized acenes and heteroacenes for organic electronics. John E AnthonyChem Rev200617165682Yes
298921251062.570.5135.3Modeling and comparison of dissolution profiles. P Costa, J M Sousa LoboEur J Pharm Sci