Unicorn Papers - Top cited papers from PUBMED

No.	Citations	EC_cit	RCR	EC_RCR	Title	Authors	Journal	Year	PMID	Article(?)
1	220948	220948.0	0.0	0.0	Cleavage of structural proteins during the assembly of the head of bacteriophage T4.	U K Laemmli	Nature	1970	5432063	Yes
2	167634	167634.0	0.0	0.0	A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.	M M Bradford	Anal Biochem	1976	942051	Yes
3	288794	72198.5	0.0	0.0	Protein measurement with the Folin phenol reagent.	O H Lowry, N J Rosebrough, A L Farr, R J Randall	J Biol Chem	1951	14907713	Yes
4	92258	46129.0	2386.9	1193.5	Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.	K J Livak, T D Schmittgen	Methods	2001	11846609	Yes
5	42648	42648.0	1464.32	1464.3	A short history of SHELX.	George M Sheldrick	Acta Crystallogr A	2008	18156677	Yes
6	33101	33101.0	1072.05	1072.0	Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.	T Mosmann	J Immunol Methods	1983	6606682	Yes
7	65251	32625.5	1976.82	988.4	Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.	P Chomczynski, N Sacchi	Anal Biochem	1987	2440339	Yes
8	30145	30145.0	0.0	0.0	Detection of specific sequences among DNA fragments separated by gel electrophoresis.	E M Southern	J Mol Biol	1975	1195397	Yes
9	24879	24879.0	0.0	0.0	The assessment and analysis of handedness: the Edinburgh inventory.	R C Oldfield	Neuropsychologia	1971	5146491	Yes
10	24306	24306.0	567.86	567.9	MicroRNAs: genomics, biogenesis, mechanism, and function.	David P Bartel	Cell	2004	14744438	No
11	23237	23237.0	0.0	0.0	A rating scale for depression.	M Hamilton	J Neurol Neurosurg Psychiatry	1960	14399272	Yes
12	21919	21919.0	687.54	687.5	Confidence Limits On Phylogenies: An Approach Using The Bootstrap.	Joseph Felsenstein	Evolution	1985	28561359	Yes
13	65213	21737.7	0.0	0.0	DNA sequencing with chain-terminating inhibitors.	F Sanger, S Nicklen, A R Coulson	Proc Natl Acad Sci U S A	1977	271968	Yes
14	20916	20916.0	500.81	500.8	A new mathematical model for relative quantification in real-time RT-PCR.	M W Pfaffl	Nucleic Acids Res	2001	11328886	Yes
15	20787	20787.0	522.81	522.8	MUSCLE: multiple sequence alignment with high accuracy and high throughput.	Robert C Edgar	Nucleic Acids Res	2004	15034147	Yes
16	19874	19874.0	0.0	0.0	The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.	E S Reynolds	J Cell Biol	1963	13986422	Yes
17	59091	19697.0	0.0	0.0	"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician.	M F Folstein, S E Folstein, P R McHugh	J Psychiatr Res	1975	1202204	Yes
18	36219	18109.5	1120.67	560.3	The neighbor-joining method: a new method for reconstructing phylogenetic trees.	N Saitou, M Nei	Mol Biol Evol	1987	3447015	Yes
19	17837	17837.0	0.0	0.0	Tissue sulfhydryl groups.	G L Ellman	Arch Biochem Biophys	1959	13650640	Yes
20	53063	17687.7	0.0	0.0	Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.	H Towbin, T Staehelin, J Gordon	Proc Natl Acad Sci U S A	1979	388439	Yes
21	16822	16822.0	0.0	0.0	Disc Electrophoresis. Ii. Method And Application To Human Serum Proteins.	B J Davis	Ann N Y Acad Sci	1964	14240539	Yes
22	16798	16798.0	0.0	0.0	High resolution two-dimensional electrophoresis of proteins.	P H O'Farrell	J Biol Chem	1975	236308	Yes
23	33120	16560.0	1609.45	804.7	Statistical methods for assessing agreement between two methods of clinical measurement.	J M Bland, D G Altman	Lancet	1986	2868172	Yes
24	15952	15952.0	567.8	567.8	Density-functional exchange-energy approximation with correct asymptotic behavior.	Becke	Phys Rev A Gen Phys	1988	9900728	Yes
25	15942	15942.0	418.69	418.7	Atherosclerosis--an inflammatory disease.	R Ross	N Engl J Med	1999	9887164	No
26	15899	15899.0	0.0	0.0	A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.	K Burton	Biochem J	1956	13293190	Yes
27	30713	15356.5	1121.38	560.7	Hallmarks of cancer: the next generation.	Douglas Hanahan, Robert A Weinberg	Cell	2011	21376230	No
28	30284	15142.0	0.0	0.0	A rapid method of total lipid extraction and purification.	E G Bligh, W J Dyer	Can J Biochem Physiol	1959	13671378	Yes
29	15026	15026.0	560.48	560.5	A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences.	M Kimura	J Mol Evol	1980	7463489	Yes
30	28732	14366.0	0.0	0.0	The measurement of observer agreement for categorical data.	J R Landis, G G Koch	Biometrics	1977	843571	Yes
31	43003	14334.3	1239.9	413.3	CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.	J D Thompson, D G Higgins, T J Gibson	Nucleic Acids Res	1994	7984417	Yes
32	41675	13891.7	0.0	0.0	A simple method for the isolation and purification of total lipides from animal tissues.	J Folch, M Lees, G H Sloane Stanley	J Biol Chem	1957	13428781	Yes
33	13083	13083.0	367.1	367.1	MicroRNAs: target recognition and regulatory functions.	David P Bartel	Cell	2009	19167326	No
34	12845	12845.0	0.0	0.0	Phosphorus assay in column chromatography.	G R Bartlett	J Biol Chem	1959	13641241	Yes
35	12623	12623.0	537.69	537.7	A power primer.	J Cohen	Psychol Bull	1992	19565683	Yes
36	24938	12469.0	965.08	482.5	Meta-analysis in clinical trials.	R DerSimonian, N Laird	Control Clin Trials	1986	3802833	Yes
37	24271	12135.5	1016.42	508.2	The hospital anxiety and depression scale.	A S Zigmond, R P Snaith	Acta Psychiatr Scand	1983	6880820	Yes
38	12127	12127.0	362.13	362.1	Projector augmented-wave method.	Blöchl	Phys Rev B Condens Matter	1994	9976227	Yes
39	11693	11693.0	465.22	465.2	Catalase in vitro.	H Aebi	Methods Enzymol	1984	6727660	Yes
40	21844	10922.0	932.68	466.3	The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection.	J E Ware, C D Sherbourne	Med Care	1992	1593914	Yes
41	54299	10859.8	1570.96	314.2	Basic local alignment search tool.	S F Altschul, W Gish, W Miller, E W Myers, D J Lipman	J Mol Biol	1990	2231712	Yes
42	21550	10775.0	559.37	279.7	A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.	A P Feinberg, B Vogelstein	Anal Biochem	1983	6312838	Yes
43	10769	10769.0	590.89	590.9	RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies.	Alexandros Stamatakis	Bioinformatics	2014	24451623	Yes
44	21059	10529.5	471.07	235.5	Coot: model-building tools for molecular graphics.	Paul Emsley, Kevin Cowtan	Acta Crystallogr D Biol Crystallogr	2004	15572765	Yes
45	31308	10436.0	981.17	327.1	Generalized Gradient Approximation Made Simple.	Perdew, Burke, Ernzerhof	Phys Rev Lett	1996	10062328	Yes
46	10306	10306.0	0.0	0.0	Improvements in epoxy resin embedding methods.	J H Luft	J Biophys Biochem Cytol	1961	13764136	Yes
47	10165	10165.0	344.26	344.3	Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS).	J F Kurtzke	Neurology	1983	6685237	Yes
48	20123	10061.5	0.0	0.0	The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.	K Weber, M Osborn	J Biol Chem	1969	5806584	Yes
49	9987	9987.0	400.69	400.7	Structure validation in chemical crystallography.	Anthony L Spek	Acta Crystallogr D Biol Crystallogr	2009	19171970	Yes
50	9891	9891.0	0.0	0.0	The genetics of Caenorhabditis elegans.	S Brenner	Genetics	1974	4366476	Yes
51	19567	9783.5	555.13	277.6	Fast and accurate short read alignment with Burrows-Wheeler transform.	Heng Li, Richard Durbin	Bioinformatics	2009	19451168	Yes
52	9718	9718.0	302.47	302.5	The Psychophysics Toolbox.	D H Brainard	Spat Vis	1997	9176952	Yes
53	19380	9690.0	438.8	219.4	[20] Processing of X-ray diffraction data collected in oscillation mode.	Zbyszek Otwinowski, Wladek Minor	Methods Enzymol	1997	27799103	Yes
54	28953	9651.0	1061.59	353.9	Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density.	Lee, Yang, Parr	Phys Rev B Condens Matter	1988	9944570	Yes
55	9440	9440.0	355.28	355.3	Search and clustering orders of magnitude faster than BLAST.	Robert C Edgar	Bioinformatics	2010	20709691	Yes
56	9415	9415.0	0.0	0.0	Self-efficacy: toward a unifying theory of behavioral change.	A Bandura	Psychol Rev	1977	847061	Yes
57	9413	9413.0	324.35	324.4	Banting lecture 1988. Role of insulin resistance in human disease.	G M Reaven	Diabetes	1988	3056758	No
58	9312	9312.0	275.48	275.5	Xds.	Wolfgang Kabsch	Acta Crystallogr D Biol Crystallogr	2010	20124692	Yes
59	9247	9247.0	269.16	269.2	Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.	P S Thomas	Proc Natl Acad Sci U S A	1980	6159641	Yes
60	9018	9018.0	240.03	240.0	Studies on transformation of Escherichia coli with plasmids.	D Hanahan	J Mol Biol	1983	6345791	Yes
61	18030	9015.0	473.91	237.0	A simple method for displaying the hydropathic character of a protein.	J Kyte, R F Doolittle	J Mol Biol	1982	7108955	Yes
62	9013	9013.0	260.13	260.1	The pathogenesis of atherosclerosis: a perspective for the 1990s.	R Ross	Nature	1993	8479518	No
63	8914	8914.0	235.28	235.3	Integrins: versatility, modulation, and signaling in cell adhesion.	R O Hynes	Cell	1992	1555235	No
64	8884	8884.0	352.09	352.1	A new method for measuring daytime sleepiness: the Epworth sleepiness scale.	M W Johns	Sleep	1991	1798888	Yes
65	17727	8863.5	809.79	404.9	The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations.	R M Baron, D A Kenny	J Pers Soc Psychol	1986	3806354	Yes
66	17695	8847.5	669.3	334.6	Fast gapped-read alignment with Bowtie 2.	Ben Langmead, Steven L Salzberg	Nat Methods	2012	22388286	Yes
67	8397	8397.0	186.5	186.5	Mfold web server for nucleic acid folding and hybridization prediction.	Michael Zuker	Nucleic Acids Res	2003	12824337	Yes
68	16766	8383.0	479.68	239.8	Quantifying heterogeneity in a meta-analysis.	Julian P T Higgins, Simon G Thompson	Stat Med	2002	12111919	Yes
69	8343	8343.0	599.09	599.1	Crystal structure refinement with SHELXL.	George M Sheldrick	Acta Crystallogr C Struct Chem	2015	25567568	Yes
70	8291	8291.0	236.79	236.8	Evolutionary trees from DNA sequences: a maximum likelihood approach.	J Felsenstein	J Mol Evol	1981	7288891	Yes
71	8261	8261.0	231.54	231.5	RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models.	Alexandros Stamatakis	Bioinformatics	2006	16928733	Yes
72	8107	8107.0	259.56	259.6	Vitamin D deficiency.	Michael F Holick	N Engl J Med	2007	17634462	No
73	8082	8082.0	0.0	0.0	On the origin of cancer cells.	O Warburg	Science	1956	13298683	Yes
74	8015	8015.0	173.68	173.7	Linear models and empirical bayes methods for assessing differential expression in microarray experiments.	Gordon K Smyth	Stat Appl Genet Mol Biol	2004	16646809	Yes
75	15945	7972.5	351.29	175.6	The hallmarks of cancer.	D Hanahan, R A Weinberg	Cell	2000	10647931	No
76	7969	7969.0	0.0	0.0	Solvent content of protein crystals.	B W Matthews	J Mol Biol	1968	5700707	Yes
77	15683	7841.5	461.31	230.7	Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set.	Kresse, Furthmüller	Phys Rev B Condens Matter	1996	9984901	Yes
78	7810	7810.0	353.29	353.3	Psychophysical bases of perceived exertion.	G A Borg	Med Sci Sports Exerc	1982	7154893	Yes
79	7759	7759.0	218.2	218.2	The role of protein kinase C in cell surface signal transduction and tumour promotion.	Y Nishizuka	Nature	1984	6232463	No
80	7721	7721.0	217.67	217.7	"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.	W N Burnette	Anal Biochem	1981	6266278	Yes
81	23064	7688.0	618.63	206.2	VMD: visual molecular dynamics.	W Humphrey, A Dalke, K Schulten	J Mol Graph	1996	8744570	Yes
82	7661	7661.0	0.0	0.0	A simplification of the protein assay method of Lowry et al. which is more generally applicable.	G L Peterson	Anal Biochem	1977	603028	Yes
83	7595	7595.0	170.17	170.2	The functions of animal microRNAs.	Victor Ambros	Nature	2004	15372042	No
84	7558	7558.0	0.0	0.0	Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.	J R Vane	Nat New Biol	1971	5284360	Yes
85	30156	7539.0	922.0	230.5	Measuring inconsistency in meta-analyses.	Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman	BMJ	2003	12958120	No
86	7372	7372.0	0.0	0.0	Copper Enzymes In Isolated Chloroplasts. Polyphenoloxidase In Beta Vulgaris.	D I Arnon	Plant Physiol	1949	16654194	Yes
87	7300	7300.0	200.25	200.2	Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.	M C Hochberg	Arthritis Rheum	1997	9324032	Yes
88	14482	7241.0	346.6	173.3	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.	Kazutoshi Takahashi, Shinya Yamanaka	Cell	2006	16904174	Yes
89	7218	7218.0	0.0	0.0	A low-viscosity epoxy resin embedding medium for electron microscopy.	A R Spurr	J Ultrastruct Res	1969	4887011	Yes
90	7137	7137.0	212.29	212.3	Semiempirical GGA-type density functional constructed with a long-range dispersion correction.	Stefan Grimme	J Comput Chem	2006	16955487	Yes
91	28199	7049.8	1090.5	272.6	A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.	M E Charlson, P Pompei, K L Ales, C R MacKenzie	J Chronic Dis	1987	3558716	Yes
92	7017	7017.0	0.0	0.0	Tumor angiogenesis: therapeutic implications.	J Folkman	N Engl J Med	1971	4938153	No
93	6989	6989.0	194.19	194.2	TreeView: an application to display phylogenetic trees on personal computers.	R D Page	Comput Appl Biosci	1996	8902363	Yes
94	6988	6988.0	0.0	0.0	Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.	A Böyum	Scand J Clin Lab Invest Suppl	1968	4179068	Yes
95	20919	6973.0	602.51	200.8	Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.	Da Wei Huang, Brad T Sherman, Richard A Lempicki	Nat Protoc	2009	19131956	Yes
96	13897	6948.5	355.6	177.8	MrBayes 3: Bayesian phylogenetic inference under mixed models.	Fredrik Ronquist, John P Huelsenbeck	Bioinformatics	2003	12912839	Yes
97	6863	6863.0	0.0	0.0	The thiobarbituric acid assay of sialic acids.	L Warren	J Biol Chem	1959	13672998	Yes
98	20566	6855.3	0.0	0.0	Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.	W T Friedewald, R I Levy, D S Fredrickson	Clin Chem	1972	4337382	Yes
99	20468	6822.7	585.52	195.2	A new generation of Ca2+ indicators with greatly improved fluorescence properties.	G Grynkiewicz, M Poenie, R Y Tsien	J Biol Chem	1985	3838314	Yes
100	47726	6818.0	1266.97	181.0	Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.	S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J Lipman	Nucleic Acids Res	1997	9254694	No
101	6729	6729.0	183.32	183.3	The steroid and thyroid hormone receptor superfamily.	R M Evans	Science	1988	3283939	No
102	6700	6700.0	204.85	204.8	AFNI: software for analysis and visualization of functional magnetic resonance neuroimages.	R W Cox	Comput Biomed Res	1996	8812068	Yes
103	13382	6691.0	0.0	0.0	Continuous cultures of fused cells secreting antibody of predefined specificity.	G Köhler, C Milstein	Nature	1975	1172191	Yes
104	26441	6610.2	886.95	221.7	Bias in meta-analysis detected by a simple, graphical test.	M Egger, G Davey Smith, M Schneider, C Minder	BMJ	1997	9310563	Yes
105	13220	6610.0	286.94	143.5	Processing of X-ray diffraction data collected in oscillation mode.	Z Otwinowski, W Minor	Methods Enzymol	1997	27754618	Yes
106	26359	6589.8	1163.84	291.0	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	PLoS Med	2009	19621072	No
107	6585	6585.0	154.49	154.5	Chromatin modifications and their function.	Tony Kouzarides	Cell	2007	17320507	No
108	6582	6582.0	177.13	177.1	Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.	F Tajima	Genetics	1989	2513255	Yes
109	13061	6530.5	379.77	189.9	Analyzing real-time PCR data by the comparative C(T) method.	Thomas D Schmittgen, Kenneth J Livak	Nat Protoc	2008	18546601	Yes
110	19479	6493.0	783.58	261.2	NIH Image to ImageJ: 25 years of image analysis.	Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri	Nat Methods	2012	22930834	No
111	6483	6483.0	172.64	172.6	Adhesion receptors of the immune system.	T A Springer	Nature	1990	1974032	No
112	6469	6469.0	227.6	227.6	The blockade of immune checkpoints in cancer immunotherapy.	Drew M Pardoll	Nat Rev Cancer	2012	22437870	No
113	6432	6432.0	309.53	309.5	Comparative fit indexes in structural models.	P M Bentler	Psychol Bull	1990	2320703	Yes
114	6429	6429.0	169.95	169.9	PAML 4: phylogenetic analysis by maximum likelihood.	Ziheng Yang	Mol Biol Evol	2007	17483113	Yes
115	6381	6381.0	257.85	257.9	Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses.	Andreas Stang	Eur J Epidemiol	2010	20652370	Yes
116	6357	6357.0	175.33	175.3	Canonical dynamics: Equilibrium phase-space distributions.	Hoover	Phys Rev A Gen Phys	1985	9895674	Yes
117	6346	6346.0	169.07	169.1	Angiogenesis in cancer, vascular, rheumatoid and other disease.	J Folkman	Nat Med	1995	7584949	No
118	12692	6346.0	294.19	147.1	Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana.	S J Clough, A F Bent	Plant J	1998	10069079	Yes
119	6345	6345.0	129.51	129.5	Rapid and efficient site-specific mutagenesis without phenotypic selection.	T A Kunkel	Proc Natl Acad Sci U S A	1985	3881765	Yes
120	12597	6298.5	0.0	0.0	Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.	Y Cheng, W H Prusoff	Biochem Pharmacol	1973	4202581	Yes
121	6290	6290.0	0.0	0.0	The assessment of anxiety states by rating.	M Hamilton	Br J Med Psychol	1959	13638508	Yes
122	6243	6243.0	163.3	163.3	Fast robust automated brain extraction.	Stephen M Smith	Hum Brain Mapp	2002	12391568	No
123	12442	6221.0	0.0	0.0	Statistical aspects of the analysis of data from retrospective studies of disease.	N Mantel, W Haenszel	J Natl Cancer Inst	1959	13655060	Yes
124	6169	6169.0	192.13	192.1	The VideoToolbox software for visual psychophysics: transforming numbers into movies.	D G Pelli	Spat Vis	1997	9176953	Yes
125	6162	6162.0	210.76	210.8	Density-functional approximation for the correlation energy of the inhomogeneous electron gas.	Perdew	Phys Rev B Condens Matter	1986	9938299	Yes
126	6122	6122.0	204.55	204.6	Ethical guidelines for investigations of experimental pain in conscious animals.	Manfred Zimmermann	Pain	1983	6877845	No
127	6120	6120.0	135.72	135.7	p53, the cellular gatekeeper for growth and division.	A J Levine	Cell	1997	9039259	No
128	12171	6085.5	0.0	0.0	A rapid alkaline extraction procedure for screening recombinant plasmid DNA.	H C Birnboim, J Doly	Nucleic Acids Res	1979	388356	Yes
129	18195	6065.0	835.67	278.6	Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.	Michael I Love, Wolfgang Huber, Simon Anders	Genome Biol	2014	25516281	Yes
130	6006	6006.0	149.88	149.9	Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm.	T A Springer	Cell	1994	7507411	No
131	23969	5992.2	0.0	0.0	Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.	J M Chirgwin, A E Przybyla, R J MacDonald, W J Rutter	Biochemistry	1979	518835	Yes
132	5933	5933.0	171.25	171.2	Apoptosis: a review of programmed cell death.	Susan Elmore	Toxicol Pathol	2007	17562483	No
133	5925	5925.0	152.22	152.2	Inositol trisphosphate and calcium signalling.	M J Berridge	Nature	1993	8381210	No
134	11811	5905.5	263.88	131.9	KEGG: kyoto encyclopedia of genes and genomes.	M Kanehisa, S Goto	Nucleic Acids Res	2000	10592173	Yes
135	5904	5904.0	151.99	152.0	G proteins: transducers of receptor-generated signals.	A G Gilman	Annu Rev Biochem	1987	3113327	No
136	11772	5886.0	0.0	0.0	Prediction of creatinine clearance from serum creatinine.	D W Cockcroft, M H Gault	Nephron	1976	1244564	Yes
137	5774	5774.0	121.13	121.1	Integrins: bidirectional, allosteric signaling machines.	Richard O Hynes	Cell	2002	12297042	No
138	5757	5757.0	190.51	190.5	The Clinical Dementia Rating (CDR): current version and scoring rules.	J C Morris	Neurology	1993	8232972	Yes
139	11507	5753.5	0.0	0.0	The Carbon Monoxide-Binding Pigment Of Liver Microsomes. I. Evidence For Its Hemoprotein Nature.	T Omura, R Sato	J Biol Chem	1964	14209971	Yes
140	5745	5745.0	133.13	133.1	Inflammation in atherosclerosis.	Peter Libby	Nature	2002	12490960	No
141	11453	5726.5	545.18	272.6	MAFFT multiple sequence alignment software version 7: improvements in performance and usability.	Kazutaka Katoh, Daron M Standley	Mol Biol Evol	2013	23329690	Yes
142	11393	5696.5	0.0	0.0	Intraclass correlations: uses in assessing rater reliability.	P E Shrout, J L Fleiss	Psychol Bull	1979	18839484	No
143	5642	5642.0	144.06	144.1	Inflammation, atherosclerosis, and coronary artery disease.	Göran K Hansson	N Engl J Med	2005	15843671	No
144	5618	5618.0	144.47	144.5	Apoptosis in the pathogenesis and treatment of disease.	C B Thompson	Science	1995	7878464	No
145	11141	5570.5	399.09	199.5	The meaning and use of the area under a receiver operating characteristic (ROC) curve.	J A Hanley, B J McNeil	Radiology	1982	7063747	Yes
146	5551	5551.0	138.27	138.3	Biochemistry and molecular cell biology of diabetic complications.	M Brownlee	Nature	2001	11742414	Yes
147	16578	5526.0	830.79	276.9	Trimmomatic: a flexible trimmer for Illumina sequence data.	Anthony M Bolger, Marc Lohse, Bjoern Usadel	Bioinformatics	2014	24695404	Yes
148	5486	5486.0	0.0	0.0	A Self-Rating Depression Scale.	W W Zung	Arch Gen Psychiatry	1965	14221692	Yes
149	5463	5463.0	271.71	271.7	Investigation of the freely available easy-to-use software 'EZR' for medical statistics.	Y Kanda	Bone Marrow Transplant	2013	23208313	Yes
150	16356	5452.0	1359.04	453.0	MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets.	Sudhir Kumar, Glen Stecher, Koichiro Tamura	Mol Biol Evol	2016	27004904	Yes
151	5440	5440.0	134.65	134.7	Free radicals in the physiological control of cell function.	Wulf Dröge	Physiol Rev	2002	11773609	No
152	10866	5433.0	251.84	125.9	Dendritic cells and the control of immunity.	J Banchereau, R M Steinman	Nature	1998	9521319	No
153	10862	5431.0	293.69	146.8	Sequencing end-labeled DNA with base-specific chemical cleavages.	A M Maxam, W Gilbert	Methods Enzymol	1980	6246368	Yes
154	10853	5426.5	0.0	0.0	A series of normal stages in the development of the chick embryo.	V Hamburger, H L Hamilton	J Morphol	1951	24539719	Yes
155	5390	5390.0	0.0	0.0	Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues.	F Tietze	Anal Biochem	1969	4388022	Yes
156	10775	5387.5	272.29	136.1	MRBAYES: Bayesian inference of phylogenetic trees.	J P Huelsenbeck, F Ronquist	Bioinformatics	2001	11524383	Yes
157	5346	5346.0	136.51	136.5	New M13 vectors for cloning.	J Messing	Methods Enzymol	1983	6310323	Yes
158	15978	5326.0	0.0	0.0	Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.	H Ohkawa, N Ohishi, K Yagi	Anal Biochem	1979	36810	Yes
159	5270	5270.0	0.0	0.0	Evaluation of survival data and two new rank order statistics arising in its consideration.	N Mantel	Cancer Chemother Rep	1966	5910392	Yes
160	5252	5252.0	153.02	153.0	Studies and perspectives of protein kinase C.	Y Nishizuka	Science	1986	3014651	No
161	5237	5237.0	104.08	104.1	BLAT--the BLAST-like alignment tool.	W James Kent	Genome Res	2002	11932250	Yes
162	5231	5231.0	0.0	0.0	Modification of seizure activity by electrical stimulation. II. Motor seizure.	R J Racine	Electroencephalogr Clin Neurophysiol	1972	4110397	Yes
163	5230	5230.0	128.0	128.0	Antimicrobial peptides of multicellular organisms.	Michael Zasloff	Nature	2002	11807545	Yes
164	5229	5229.0	118.75	118.8	The biochemistry of apoptosis.	M O Hengartner	Nature	2000	11048727	No
165	5225	5225.0	142.65	142.7	The Cambridge Structural Database: a quarter of a million crystal structures and rising.	Frank H Allen	Acta Crystallogr B	2002	12037359	Yes
166	5221	5221.0	0.0	0.0	[A micro-method of immuno-electrophoresis].	J J Scheidegger	Int Arch Allergy Appl Immunol	1955	13262900	Yes
167	10391	5195.5	300.68	150.3	MODELTEST: testing the model of DNA substitution.	D Posada, K A Crandall	Bioinformatics	1998	9918953	Yes
168	15550	5183.3	472.1	157.4	A simple salting out procedure for extracting DNA from human nucleated cells.	S A Miller, D D Dykes, H F Polesky	Nucleic Acids Res	1988	3344216	Yes
169	5180	5180.0	189.31	189.3	The Strengths and Difficulties Questionnaire: a research note.	R Goodman	J Child Psychol Psychiatry	1997	9255702	Yes
170	5161	5161.0	0.0	0.0	Selective extraction of polyoma DNA from infected mouse cell cultures.	B Hirt	J Mol Biol	1967	4291934	Yes
171	5152	5152.0	190.28	190.3	Oxygen-derived free radicals in postischemic tissue injury.	J M McCord	N Engl J Med	1985	2981404	No
172	10302	5151.0	243.46	121.7	Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features.	W Kabsch, C Sander	Biopolymers	1983	6667333	Yes
173	10186	5093.0	250.44	125.2	A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood.	Stéphane Guindon, Olivier Gascuel	Syst Biol	2003	14530136	Yes
174	5092	5092.0	126.11	126.1	The NF-kappa B and I kappa B proteins: new discoveries and insights.	A S Baldwin	Annu Rev Immunol	1996	8717528	No
175	5083	5083.0	0.0	0.0	The Environment And Disease: Association Or Causation?	A B Hill	Proc R Soc Med	1965	14283879	Yes
176	15239	5079.7	502.52	167.5	Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.	Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien	Ann Surg	2004	15273542	Yes
177	25376	5075.2	700.23	140.0	The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.	J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G Higgins	Nucleic Acids Res	1997	9396791	Yes
178	5068	5068.0	0.0	0.0	Mutation and cancer: statistical study of retinoblastoma.	A G Knudson	Proc Natl Acad Sci U S A	1971	5279523	Yes
179	10077	5038.5	374.31	187.2	The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.	R F Furchgott, J V Zawadzki	Nature	1980	6253831	Yes
180	10008	5004.0	266.8	133.4	Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa.	H Schägger, G von Jagow	Anal Biochem	1987	2449095	Yes
181	4979	4979.0	0.0	0.0	A protein binding assay for adenosine 3':5'-cyclic monophosphate.	A G Gilman	Proc Natl Acad Sci U S A	1970	4318781	Yes
182	4977	4977.0	0.0	0.0	Aging: a theory based on free radical and radiation chemistry.	D Harman	J Gerontol	1956	13332224	Yes
183	4960	4960.0	202.18	202.2	Orienting of attention.	M I Posner	Q J Exp Psychol	1980	7367577	Yes
184	4959	4959.0	174.27	174.3	jModelTest: phylogenetic model averaging.	David Posada	Mol Biol Evol	2008	18397919	Yes
185	4954	4954.0	130.3	130.3	Inflammation and metabolic disorders.	Gökhan S Hotamisligil	Nature	2006	17167474	No
186	4935	4935.0	0.0	0.0	Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.	C B Laurell	Anal Biochem	1966	5959431	Yes
187	4935	4935.0	182.69	182.7	Analyzing Tables Of Statistical Tests.	William R Rice	Evolution	1989	28568501	Yes
188	9865	4932.5	227.42	113.7	One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.	K A Datsenko, B L Wanner	Proc Natl Acad Sci U S A	2000	10829079	Yes
189	4929	4929.0	0.0	0.0	Development of a rating scale for primary depressive illness.	M Hamilton	Br J Soc Clin Psychol	1967	6080235	Yes
190	14786	4928.7	539.26	179.8	Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.	S M Hsu, L Raine, H Fanger	J Histochem Cytochem	1981	6166661	Yes
191	4919	4919.0	102.26	102.3	Rho GTPases and the actin cytoskeleton.	A Hall	Science	1998	9438836	No
192	4908	4908.0	0.0	0.0	Metabolism Of Isolated Fat Cells. I. Effects Of Hormones On Glucose Metabolism And Lipolysis.	M Rodbell	J Biol Chem	1964	14169133	Yes
193	9793	4896.5	357.28	178.6	Ligand: a versatile computerized approach for characterization of ligand-binding systems.	P J Munson, D Rodbard	Anal Biochem	1980	6254391	Yes
194	4894	4894.0	116.71	116.7	Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis.	J Castresana	Mol Biol Evol	2000	10742046	Yes
195	14483	4827.7	394.2	131.4	Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors.	C Yanisch-Perron, J Vieira, J Messing	Gene	1985	2985470	Yes
196	9654	4827.0	275.01	137.5	Neuropathological stageing of Alzheimer-related changes.	H Braak, E Braak	Acta Neuropathol	1991	1759558	No
197	4823	4823.0	257.71	257.7	UPARSE: highly accurate OTU sequences from microbial amplicon reads.	Robert C Edgar	Nat Methods	2013	23955772	Yes
198	14465	4821.7	360.09	120.0	A comprehensive set of sequence analysis programs for the VAX.	J Devereux, P Haeberli, O Smithies	Nucleic Acids Res	1984	6546423	Yes
199	14443	4814.3	0.0	0.0	Determination of serum proteins by means of the biuret reaction.	A G Gornall, C J Bardawill, M M David	J Biol Chem	1949	18110453	Yes
200	4808	4808.0	134.05	134.1	Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.	P Matsudaira	J Biol Chem	1987	3611052	Yes
201	4808	4808.0	98.88	98.9	Epithelial-mesenchymal transitions in tumour progression.	Jean Paul Thiery	Nat Rev Cancer	2002	12189386	No
202	9525	4762.5	0.0	0.0	A quantitative description of membrane current and its application to conduction and excitation in nerve.	A L Hodgkin, A F Huxley	J Physiol	1952	12991237	Yes
203	4762	4762.0	97.06	97.1	An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.	M Kozak	Nucleic Acids Res	1987	3313277	No
204	4759	4759.0	144.32	144.3	Developments of a water-maze procedure for studying spatial learning in the rat.	R Morris	J Neurosci Methods	1984	6471907	Yes
205	14277	4759.0	431.73	143.9	edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.	Mark D Robinson, Davis J McCarthy, Gordon K Smyth	Bioinformatics	2010	19910308	Yes
206	9437	4718.5	0.0	0.0	A new technique for the assay of infectivity of human adenovirus 5 DNA.	F L Graham, A J van der Eb	Virology	1973	4705382	Yes
207	9363	4681.5	346.68	173.3	Three approaches to qualitative content analysis.	Hsiu-Fang Hsieh, Sarah E Shannon	Qual Health Res	2005	16204405	Yes
208	13963	4654.3	436.46	145.5	The PHQ-9: validity of a brief depression severity measure.	K Kroenke, R L Spitzer, J B Williams	J Gen Intern Med	2001	11556941	Yes
209	4653	4653.0	106.37	106.4	ras oncogenes in human cancer: a review.	J L Bos	Cancer Res	1989	2547513	No
210	9306	4653.0	236.85	118.4	Improved tools for biological sequence comparison.	W R Pearson, D J Lipman	Proc Natl Acad Sci U S A	1988	3162770	Yes
211	4647	4647.0	158.67	158.7	The pathogenesis of atherosclerosis--an update.	R Ross	N Engl J Med	1986	3511384	No
212	4645	4645.0	0.0	0.0	The Two Histological Main Types Of Gastric Carcinoma: Diffuse And So-Called Intestinal-Type Carcinoma. An Attempt At A Histo-Clinical Classification.	P Lauren	Acta Pathol Microbiol Scand	1965	14320675	Yes
213	13921	4640.3	490.07	163.4	Nitric oxide: physiology, pathophysiology, and pharmacology.	S Moncada, R M Palmer, E A Higgs	Pharmacol Rev	1991	1852778	No
214	4623	4623.0	118.06	118.1	Emotion circuits in the brain.	J E LeDoux	Annu Rev Neurosci	2000	10845062	No
215	9214	4607.0	227.81	113.9	A genetic model for colorectal tumorigenesis.	E R Fearon, B Vogelstein	Cell	1990	2188735	No
216	4601	4601.0	104.22	104.2	Cancer cell cycles.	C J Sherr	Science	1996	8939849	No
217	9180	4590.0	223.98	112.0	Comparative protein modelling by satisfaction of spatial restraints.	A Sali, T L Blundell	J Mol Biol	1993	8254673	Yes
218	4589	4589.0	132.85	132.8	A modified poisson regression approach to prospective studies with binary data.	Guangyong Zou	Am J Epidemiol	2004	15033648	Yes
219	4579	4579.0	0.0	0.0	Aggregation of blood platelets by adenosine diphosphate and its reversal.	G V Born	Nature	1962	13871375	Yes
220	4578	4578.0	0.0	0.0	A rapid banding technique for human chromosomes.	M Seabright	Lancet	1971	4107917	Yes
221	18263	4565.8	575.88	144.0	MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0.	Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir Kumar	Mol Biol Evol	2007	17488738	Yes
222	4563	4563.0	268.95	268.9	Prokka: rapid prokaryotic genome annotation.	Torsten Seemann	Bioinformatics	2014	24642063	Yes
223	9068	4534.0	0.0	0.0	Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).	J M McCord, I Fridovich	J Biol Chem	1969	5389100	Yes
224	9064	4532.0	0.0	0.0	A new depression scale designed to be sensitive to change.	S A Montgomery, M Asberg	Br J Psychiatry	1979	444788	Yes
225	8981	4490.5	207.14	103.6	The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.	John Hardy, Dennis J Selkoe	Science	2002	12130773	No
226	4482	4482.0	0.0	0.0	The clonal evolution of tumor cell populations.	P C Nowell	Science	1976	959840	Yes
227	8960	4480.0	202.22	101.1	Inflammation and cancer.	Lisa M Coussens, Zena Werb	Nature	2002	12490959	No
228	13393	4464.3	518.63	172.9	The positive and negative syndrome scale (PANSS) for schizophrenia.	S R Kay, A Fiszbein, L A Opler	Schizophr Bull	1987	3616518	Yes
229	4449	4449.0	97.58	97.6	ras genes.	M Barbacid	Annu Rev Biochem	1987	3304147	No
230	4446	4446.0	109.26	109.3	A new method for predicting signal sequence cleavage sites.	G von Heijne	Nucleic Acids Res	1986	3714490	Yes
231	13324	4441.3	302.11	100.7	Refinement of macromolecular structures by the maximum-likelihood method.	G N Murshudov, A A Vagin, E J Dodson	Acta Crystallogr D Biol Crystallogr	1997	15299926	Yes
232	8873	4436.5	0.0	0.0	A simplified method of evaluating dose-effect experiments.	J T Litchfield, F Wilcoxon	J Pharmacol Exp Ther	1949	18152921	Yes
233	8852	4426.0	260.5	130.2	EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis.	Arnaud Delorme, Scott Makeig	J Neurosci Methods	2004	15102499	Yes
234	4409	4409.0	305.12	305.1	SHELXT - integrated space-group and crystal-structure determination.	George M Sheldrick	Acta Crystallogr A Found Adv	2015	25537383	Yes
235	4402	4402.0	95.4	95.4	Targeting HIF-1 for cancer therapy.	Gregg L Semenza	Nat Rev Cancer	2003	13130303	No
236	4399	4399.0	0.0	0.0	The McGill Pain Questionnaire: major properties and scoring methods.	Ronald Melzack	Pain	1975	1235985	Yes
237	8786	4393.0	0.0	0.0	A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.	W M Bonner, R A Laskey	Eur J Biochem	1974	4850204	Yes
238	26357	4392.8	3437.52	572.9	Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.	Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal	CA Cancer J Clin	2018	30207593	Yes
239	21812	4362.4	0.0	0.0	An inventory for measuring depression.	A T Beck, C H Ward, M Mendelson, J Mock, J Erbaugh	Arch Gen Psychiatry	1961	13688369	Yes
240	4361	4361.0	134.05	134.1	A fast diffeomorphic image registration algorithm.	John Ashburner	Neuroimage	2007	17761438	Yes
241	4349	4349.0	100.87	100.9	Alzheimer's disease: genes, proteins, and therapy.	D J Selkoe	Physiol Rev	2001	11274343	No
242	4346	4346.0	89.59	89.6	Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.	M Kozak	Cell	1986	3943125	Yes
243	4344	4344.0	0.0	0.0	Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents.	M M Mesulam	J Histochem Cytochem	1978	24068	Yes
244	13009	4336.3	333.07	111.0	Inference of population structure using multilocus genotype data.	J K Pritchard, M Stephens, P Donnelly	Genetics	2000	10835412	Yes
245	8659	4329.5	199.95	100.0	Primer3 on the WWW for general users and for biologist programmers.	S Rozen, H Skaletsky	Methods Mol Biol	2000	10547847	Yes
246	21637	4327.4	1166.47	233.3	MEGA6: Molecular Evolutionary Genetics Analysis version 6.0.	Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir Kumar	Mol Biol Evol	2013	24132122	Yes
247	4318	4318.0	85.48	85.5	DNA methylation patterns and epigenetic memory.	Adrian Bird	Genes Dev	2002	11782440	No
248	8626	4313.0	232.58	116.3	BEDTools: a flexible suite of utilities for comparing genomic features.	Aaron R Quinlan, Ira M Hall	Bioinformatics	2010	20110278	Yes
249	8625	4312.5	306.06	153.0	AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading.	Oleg Trott, Arthur J Olson	J Comput Chem	2010	19499576	Yes
250	4305	4305.0	0.0	0.0	Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation.	W H Harris	J Bone Joint Surg Am	1969	5783851	Yes
251	4298	4298.0	0.0	0.0	Index for rating diagnostic tests.	W J Youden	Cancer	1950	15405679	Yes
252	8592	4296.0	0.0	0.0	Preparation of iodine-131 labelled human growth hormone of high specific activity.	W M Hunter, F C Greenwood	Nature	1962	14450081	Yes
253	4294	4294.0	112.62	112.6	Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C.	Y Nishizuka	Science	1992	1411571	No
254	4293	4293.0	99.81	99.8	Prions.	S B Prusiner	Proc Natl Acad Sci U S A	1998	9811807	No
255	4283	4283.0	101.43	101.4	MUSCLE: a multiple sequence alignment method with reduced time and space complexity.	Robert C Edgar	BMC Bioinformatics	2004	15318951	Yes
256	4264	4264.0	0.0	0.0	The Limited In Vitro Lifetime Of Human Diploid Cell Strains.	L Hayflick	Exp Cell Res	1965	14315085	Yes
257	8504	4252.0	288.69	144.3	Operating characteristics of a rank correlation test for publication bias.	C B Begg, M Mazumdar	Biometrics	1994	7786990	Yes
258	4250	4250.0	113.39	113.4	The molecular heterogeneity of protein kinase C and its implications for cellular regulation.	Y Nishizuka	Nature	1988	3045562	No
259	16993	4248.2	607.65	151.9	G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences.	Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner	Behav Res Methods	2007	17695343	Yes
260	8435	4217.5	0.0	0.0	Parkinsonism: onset, progression and mortality.	M M Hoehn, M D Yahr	Neurology	1967	6067254	Yes
261	4211	4211.0	112.89	112.9	Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation.	A H Wyllie	Nature	1980	6245367	Yes
262	4208	4208.0	94.42	94.4	Apoptosis by death factor.	S Nagata	Cell	1997	9039262	No
263	4205	4205.0	100.28	100.3	Cancer. p53, guardian of the genome.	D P Lane	Nature	1992	1614522	No
264	4204	4204.0	94.35	94.3	Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing.	S Henikoff	Gene	1984	6235151	Yes
265	4199	4199.0	0.0	0.0	Amino acid metabolism in mammalian cell cultures.	H Eagle	Science	1959	13675766	Yes
266	25171	4195.2	1028.07	171.3	Global cancer statistics.	Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David Forman	CA Cancer J Clin	2011	21296855	Yes
267	4195	4195.0	119.71	119.7	Mild cognitive impairment as a diagnostic entity.	R C Petersen	J Intern Med	2004	15324362	No
268	4191	4191.0	0.0	0.0	A relation between non-esterified fatty acids in plasma and the metabolism of glucose.	V P Dole	J Clin Invest	1956	13286333	Yes
269	4186	4186.0	167.77	167.8	Revisiting the behavioral model and access to medical care: does it matter?	R M Andersen	J Health Soc Behav	1995	7738325	Yes
270	8365	4182.5	229.24	114.6	A synaptic model of memory: long-term potentiation in the hippocampus.	T V Bliss, G L Collingridge	Nature	1993	8421494	No
271	4177	4177.0	0.0	0.0	The colorimetric estimation of formaldehyde by means of the Hantzsch reaction.	T Nash	Biochem J	1953	13105648	Yes
272	4169	4169.0	0.0	0.0	Estimation of nuclear population from microtome sections.	M Abercrombie	Anat Rec	1946	21015608	Yes
273	4119	4119.0	0.0	0.0	The genetical evolution of social behaviour. I.	W D Hamilton	J Theor Biol	1964	5875341	Yes
274	8238	4119.0	247.96	124.0	The rise of graphene.	A K Geim, K S Novoselov	Nat Mater	2007	17330084	Yes
275	8232	4116.0	178.52	89.3	Genomic sequencing.	G M Church, W Gilbert	Proc Natl Acad Sci U S A	1984	6326095	Yes
276	8214	4107.0	239.25	119.6	Differential expression analysis for sequence count data.	Simon Anders, Wolfgang Huber	Genome Biol	2010	20979621	Yes
277	4104	4104.0	0.0	0.0	The need for a new medical model: a challenge for biomedicine.	G L Engel	Science	1977	847460	Yes
278	8206	4103.0	0.0	0.0	Assessment of coma and impaired consciousness. A practical scale.	G Teasdale, B Jennett	Lancet	1974	4136544	Yes
279	8198	4099.0	195.25	97.6	SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling.	N Guex, M C Peitsch	Electrophoresis	1997	9504803	Yes
280	4086	4086.0	87.31	87.3	The retinoblastoma protein and cell cycle control.	R A Weinberg	Cell	1995	7736585	No
281	4085	4085.0	125.07	125.1	Glutamate neurotoxicity and diseases of the nervous system.	D W Choi	Neuron	1988	2908446	No
282	4084	4084.0	98.86	98.9	Mechanisms of angiogenesis.	W Risau	Nature	1997	9109485	No
283	24488	4081.3	1054.36	175.7	MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods.	Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir Kumar	Mol Biol Evol	2011	21546353	Yes
284	16321	4080.2	0.0	0.0	A new and rapid colorimetric determination of acetylcholinesterase activity.	G L Ellman, K D Courtney, V Andres, R M Feather-Stone	Biochem Pharmacol	1961	13726518	Yes
285	4067	4067.0	87.01	87.0	Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.	C J Marshall	Cell	1995	7834738	No
286	4067	4067.0	0.0	0.0	The determination of enzyme inhibitor constants.	M Dixon	Biochem J	1953	13093635	Yes
287	4052	4052.0	0.0	0.0	Determination of protein: a modification of the Lowry method that gives a linear photometric response.	E F Hartree	Anal Biochem	1972	4115981	Yes
288	4034	4034.0	88.69	88.7	Alternative activation of macrophages.	Siamon Gordon	Nat Rev Immunol	2003	12511873	No
289	4012	4012.0	75.53	75.5	Generalized lacZ expression with the ROSA26 Cre reporter strain.	P Soriano	Nat Genet	1999	9916792	Yes
290	3989	3989.0	80.0	80.0	The phosphoinositide 3-kinase pathway.	Lewis C Cantley	Science	2002	12040186	No
291	3985	3985.0	0.0	0.0	Staining of tissue sections for electron microscopy with heavy metals.	M L Watson	J Biophys Biochem Cytol	1958	13563554	Yes
292	3957	3957.0	0.0	0.0	Bone: formation by autoinduction.	M R Urist	Science	1965	5319761	Yes
293	3948	3948.0	0.0	0.0	Disc Electrophoresis. I. Background And Theory.	L Ornstein	Ann N Y Acad Sci	1964	14240533	Yes
294	3946	3946.0	126.02	126.0	Bacterial evolution.	C R Woese	Microbiol Rev	1987	2439888	No
295	3946	3946.0	103.35	103.3	Integrins: a family of cell surface receptors.	R O Hynes	Cell	1987	3028640	No
296	7844	3922.0	0.0	0.0	Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.	H Aviv, P Leder	Proc Natl Acad Sci U S A	1972	4504350	Yes
297	3903	3903.0	86.77	86.8	Wnt/beta-catenin signaling in development and disease.	Hans Clevers	Cell	2006	17081971	No
298	3901	3901.0	129.33	129.3	Tissue destruction by neutrophils.	S J Weiss	N Engl J Med	1989	2536474	No
299	3895	3895.0	121.01	121.0	How mitochondria produce reactive oxygen species.	Michael P Murphy	Biochem J	2009	19061483	No
300	3893	3893.0	0.0	0.0	The detection of disease clustering and a generalized regression approach.	N Mantel	Cancer Res	1967	6018555	Yes
301	3879	3879.0	0.0	0.0	Pharmacological implications of microsomal enzyme induction.	A H Conney	Pharmacol Rev	1967	4383307	Yes
302	3870	3870.0	120.67	120.7	Nitric oxide as a secretory product of mammalian cells.	C Nathan	FASEB J	1992	1381691	No
303	3859	3859.0	107.43	107.4	What is the evidence that tumors are angiogenesis dependent?	J Folkman	J Natl Cancer Inst	1990	1688381	No
304	7644	3822.0	0.0	0.0	Functional Evaluation: The Barthel Index.	F I Mahoney, D W Barthel	Md State Med J	1965	14258950	Yes
305	3815	3815.0	87.41	87.4	PAML: a program package for phylogenetic analysis by maximum likelihood.	Z Yang	Comput Appl Biosci	1997	9367129	Yes
306	11415	3805.0	836.85	278.9	Cancer statistics, 2016.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2016	26742998	Yes
307	3803	3803.0	159.17	159.2	An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies.	Peter C Austin	Multivariate Behav Res	2011	21818162	Yes
308	7600	3800.0	0.0	0.0	Assessment of older people: self-maintaining and instrumental activities of daily living.	M P Lawton, E M Brody	Gerontologist	1969	5349366	Yes
309	11397	3799.0	0.0	0.0	Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.	W H Habig, M J Pabst, W B Jakoby	J Biol Chem	1974	4436300	Yes
310	7581	3790.5	0.0	0.0	Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.	D E Paglia, W N Valentine	J Lab Clin Med	1967	6066618	Yes
311	3774	3774.0	80.45	80.5	A catalogue of splice junction sequences.	S M Mount	Nucleic Acids Res	1982	7063411	Yes
312	3757	3757.0	104.76	104.8	Revisions in the International System for Staging Lung Cancer.	C F Mountain	Chest	1997	9187198	Yes
313	3755	3755.0	0.0	0.0	Estimation of the molecular weights of proteins by Sephadex gel-filtration.	P Andrews	Biochem J	1964	4158310	Yes
314	3747	3747.0	0.0	0.0	New methods for calculating metabolic rate with special reference to protein metabolism.	J B De B Weir	J Physiol	1949	15394301	Yes
315	3734	3734.0	84.69	84.7	Atherosclerosis.	A J Lusis	Nature	2000	11001066	No
316	3733	3733.0	0.0	0.0	Preparation of isolated rat liver cells.	P O Seglen	Methods Cell Biol	1976	177845	No
317	7449	3724.5	141.16	70.6	A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.	R S Sikorski, P Hieter	Genetics	1989	2659436	Yes
318	3724	3724.0	107.65	107.7	Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity.	J H Morrissey	Anal Biochem	1981	6172996	Yes
319	7416	3708.0	183.92	92.0	Collective dynamics of 'small-world' networks.	D J Watts, S H Strogatz	Nature	1998	9623998	Yes
320	11121	3707.0	215.2	71.7	Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.	J D Dignam, R M Lebovitz, R G Roeder	Nucleic Acids Res	1983	6828386	Yes
321	3704	3704.0	139.18	139.2	EuroQol: the current state of play.	R Brooks	Health Policy	1996	10158943	No
322	3703	3703.0	80.66	80.7	The green fluorescent protein.	R Y Tsien	Annu Rev Biochem	1998	9759496	No
323	3702	3702.0	0.0	0.0	A membrane-filter technique for the detection of complementary DNA.	D T Denhardt	Biochem Biophys Res Commun	1966	5963888	Yes
324	7388	3694.0	219.28	109.6	Estimating F-Statistics For The Analysis Of Population Structure.	B S Weir, C Clark Cockerham	Evolution	1984	28563791	Yes
325	11016	3672.0	0.0	0.0	Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.	J F Kerr, A H Wyllie, A R Currie	Br J Cancer	1972	4561027	No
326	22015	3669.2	741.1	123.5	Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.	D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C Turner	Diabetologia	1985	3899825	Yes
327	3663	3663.0	130.1	130.1	Whatever happened to qualitative description?	M Sandelowski	Res Nurs Health	2000	10940958	No
328	3647	3647.0	0.0	0.0	A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients.	E Pfeiffer	J Am Geriatr Soc	1975	1159263	Yes
329	3644	3644.0	90.75	90.8	Multiple sequence alignment with hierarchical clustering.	F Corpet	Nucleic Acids Res	1988	2849754	Yes
330	3641	3641.0	124.13	124.1	Updating P300: an integrative theory of P3a and P3b.	John Polich	Clin Neurophysiol	2007	17573239	No
331	7278	3639.0	177.51	88.8	MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification.	Jürgen Cox, Matthias Mann	Nat Biotechnol	2008	19029910	Yes
332	10909	3636.3	492.41	164.1	Development and validation of brief measures of positive and negative affect: the PANAS scales.	D Watson, L A Clark, A Tellegen	J Pers Soc Psychol	1988	3397865	Yes
333	3634	3634.0	88.14	88.1	Free R value: a novel statistical quantity for assessing the accuracy of crystal structures.	A T Brünger	Nature	1992	18481394	Yes
334	3633	3633.0	89.26	89.3	Caspases: the executioners of apoptosis.	G M Cohen	Biochem J	1997	9337844	No
335	7263	3631.5	182.42	91.2	Mitochondria and apoptosis.	D R Green, J C Reed	Science	1998	9721092	No
336	3623	3623.0	98.63	98.6	Staphylococcus aureus infections.	F D Lowy	N Engl J Med	1998	9709046	No
337	3616	3616.0	77.42	77.4	TGF-beta signal transduction.	J Massagué	Annu Rev Biochem	1998	9759503	No
338	7231	3615.5	0.0	0.0	The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.	R C Graham, M J Karnovsky	J Histochem Cytochem	1966	5962951	Yes
339	14438	3609.5	401.62	100.4	Global cancer statistics, 2002.	D Max Parkin, Freddie Bray, J Ferlay, Paola Pisani	CA Cancer J Clin	2005	15761078	Yes
340	7196	3598.0	208.75	104.4	Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy.	Florian Weigend, Reinhart Ahlrichs	Phys Chem Chem Phys	2005	16240044	Yes
341	3594	3594.0	83.76	83.8	Tandem repeats finder: a program to analyze DNA sequences.	G Benson	Nucleic Acids Res	1999	9862982	Yes
342	3593	3593.0	109.75	109.8	Inositol trisphosphate and diacylglycerol as second messengers.	M J Berridge	Biochem J	1984	6146314	No
343	3590	3590.0	0.0	0.0	Evolution in Mendelian Populations.	S Wright	Genetics	1931	17246615	Yes
344	3574	3574.0	0.0	0.0	Principles that govern the folding of protein chains.	C B Anfinsen	Science	1973	4124164	Yes
345	3565	3565.0	91.16	91.2	Why most published research findings are false.	John P A Ioannidis	PLoS Med	2005	16060722	Yes
346	3543	3543.0	65.74	65.7	Somatic generation of antibody diversity.	S Tonegawa	Nature	1983	6300689	No
347	7069	3534.5	286.8	143.4	Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models.	Kristopher J Preacher, Andrew F Hayes	Behav Res Methods	2008	18697684	Yes
348	7029	3514.5	133.4	66.7	Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.	A H Brand, N Perrimon	Development	1993	8223268	Yes
349	7023	3511.5	251.43	125.7	DnaSP v5: a software for comprehensive analysis of DNA polymorphism data.	P Librado, J Rozas	Bioinformatics	2009	19346325	Yes
350	3508	3508.0	73.58	73.6	Hypoxia--a key regulatory factor in tumour growth.	Adrian L Harris	Nat Rev Cancer	2002	11902584	No
351	14003	3500.8	417.07	104.3	Features and development of Coot.	P Emsley, B Lohkamp, W G Scott, K Cowtan	Acta Crystallogr D Biol Crystallogr	2010	20383002	Yes
352	3499	3499.0	75.41	75.4	Protein secondary structure prediction based on position-specific scoring matrices.	D T Jones	J Mol Biol	1999	10493868	Yes
353	3495	3495.0	98.69	98.7	Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group.	R B D'Agostino	Stat Med	1998	9802183	Yes
354	3493	3493.0	70.34	70.3	Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.	G R Martin	Proc Natl Acad Sci U S A	1981	6950406	Yes
355	10476	3492.0	907.33	302.4	Cancer Statistics, 2017.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2017	28055103	Yes
356	3490	3490.0	98.52	98.5	Biological roles of oligosaccharides: all of the theories are correct.	A Varki	Glycobiology	1993	8490246	No
357	3489	3489.0	82.08	82.1	Novel proteinaceous infectious particles cause scrapie.	S B Prusiner	Science	1982	6801762	Yes
358	6972	3486.0	226.14	113.1	RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome.	Bo Li, Colin N Dewey	BMC Bioinformatics	2011	21816040	Yes
359	3482	3482.0	0.0	0.0	Statistical estimations in enzyme kinetics.	G N Wilkinson	Biochem J	1961	13785321	Yes
360	3478	3478.0	0.0	0.0	Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit.	J Cohen	Psychol Bull	1968	19673146	Yes
361	3477	3477.0	102.13	102.1	Sequencing technologies - the next generation.	Michael L Metzker	Nat Rev Genet	2010	19997069	No
362	3472	3472.0	84.58	84.6	Marrow stromal cells as stem cells for nonhematopoietic tissues.	D J Prockop	Science	1997	9082988	No
363	6933	3466.5	0.0	0.0	A new method for sequencing DNA.	A M Maxam, W Gilbert	Proc Natl Acad Sci U S A	1977	265521	Yes
364	17310	3462.0	504.32	100.9	Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.	O P Hamill, A Marty, E Neher, B Sakmann, F J Sigworth	Pflugers Arch	1981	6270629	Yes
365	3461	3461.0	0.0	0.0	Spectroscopic determination of tryptophan and tyrosine in proteins.	H Edelhoch	Biochemistry	1967	6049437	Yes
366	3456	3456.0	118.16	118.2	Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD.	Russell A Barkley	Psychol Bull	1997	9000892	No
367	3453	3453.0	133.08	133.1	Measuring the accuracy of diagnostic systems.	J A Swets	Science	1988	3287615	No
368	3452	3452.0	80.43	80.4	Protein production by auto-induction in high density shaking cultures.	F William Studier	Protein Expr Purif	2005	15915565	Yes
369	6880	3440.0	164.0	82.0	"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.	A P Feinberg, B Vogelstein	Anal Biochem	1984	6329026	Yes
370	6870	3435.0	156.52	78.3	Functional rafts in cell membranes.	K Simons, E Ikonen	Nature	1997	9177342	No
371	6854	3427.0	0.0	0.0	Radiological assessment of osteo-arthrosis.	J H Kellgren, J S Lawrence	Ann Rheum Dis	1957	13498604	Yes
372	3419	3419.0	0.0	0.0	The Scree Test For The Number Of Factors.	R B Cattell	Multivariate Behav Res	1966	26828106	Yes
373	3417	3417.0	78.37	78.4	Instability and decay of the primary structure of DNA.	T Lindahl	Nature	1993	8469282	No
374	10249	3416.3	395.76	131.9	A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity.	J Ware, M Kosinski, S D Keller	Med Care	1996	8628042	Yes
375	3414	3414.0	81.54	81.5	Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.	Rakesh K Jain	Science	2005	15637262	No
376	6817	3408.5	177.13	88.6	tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence.	T M Lowe, S R Eddy	Nucleic Acids Res	1997	9023104	Yes
377	3404	3404.0	0.0	0.0	Generalized expectancies for internal versus external control of reinforcement.	J B Rotter	Psychol Monogr	1966	5340840	No
378	6796	3398.0	253.31	126.7	Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness.	U H Graneheim, B Lundman	Nurse Educ Today	2004	14769454	No
379	3385	3385.0	70.98	71.0	Mammalian neural stem cells.	F H Gage	Science	2000	10688783	No
380	3377	3377.0	0.0	0.0	Basic principles of ROC analysis.	C E Metz	Semin Nucl Med	1978	112681	Yes
381	10128	3376.0	0.0	0.0	The Preparation Of I-131-Labelled Human Growth Hormone Of High Specific Radioactivity.	F C Greenwood, W M Hunter, J S Glover	Biochem J	1963	14097352	Yes
382	3370	3370.0	0.0	0.0	The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid.	J F Woessner	Arch Biochem Biophys	1961	13786180	Yes
383	6720	3360.0	207.6	103.8	BEAST: Bayesian evolutionary analysis by sampling trees.	Alexei J Drummond, Andrew Rambaut	BMC Evol Biol	2007	17996036	Yes
384	3337	3337.0	102.96	103.0	Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans.	L R Squire	Psychol Rev	1992	1594723	No
385	3334	3334.0	83.58	83.6	The heat-shock response.	S Lindquist	Annu Rev Biochem	1986	2427013	No
386	6660	3330.0	172.66	86.3	TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.	T R Mosmann, R L Coffman	Annu Rev Immunol	1989	2523712	No
387	3326	3326.0	68.82	68.8	Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.	M Kozak	Nucleic Acids Res	1984	6694911	Yes
388	6649	3324.5	286.53	143.3	The timed "Up & Go": a test of basic functional mobility for frail elderly persons.	D Podsiadlo, S Richardson	J Am Geriatr Soc	1991	1991946	Yes
389	3316	3316.0	78.93	78.9	The dendritic cell system and its role in immunogenicity.	R M Steinman	Annu Rev Immunol	1991	1910679	No
390	3312	3312.0	0.0	0.0	Equilibrium Ultracentrifugation Of Dilute Solutions.	D A Yphantis	Biochemistry	1964	14155091	Yes
391	9936	3312.0	469.55	156.5	Cancer statistics, 2013.	Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal	CA Cancer J Clin	2013	23335087	Yes
392	3310	3310.0	68.64	68.6	The scanning model for translation: an update.	M Kozak	J Cell Biol	1989	2645293	No
393	3310	3310.0	77.32	77.3	Scaling and assessment of data quality.	Philip Evans	Acta Crystallogr D Biol Crystallogr	2006	16369096	No
394	3304	3304.0	88.28	88.3	Microglia: a sensor for pathological events in the CNS.	G W Kreutzberg	Trends Neurosci	1996	8843599	No
395	3299	3299.0	84.42	84.4	Gene regulation by steroid hormones.	M Beato	Cell	1989	2644044	No
396	3299	3299.0	0.0	0.0	Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.	J D Rowley	Nature	1973	4126434	Yes
397	6588	3294.0	176.72	88.4	Control of goal-directed and stimulus-driven attention in the brain.	Maurizio Corbetta, Gordon L Shulman	Nat Rev Neurosci	2002	11994752	No
398	3291	3291.0	99.72	99.7	What's wrong with Bonferroni adjustments.	T V Perneger	BMJ	1998	9553006	No
399	3289	3289.0	65.21	65.2	Signal transduction by the JNK group of MAP kinases.	R J Davis	Cell	2000	11057897	No
400	3285	3285.0	92.13	92.1	Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.	R W Mahley	Science	1988	3283935	No
401	9839	3279.7	1154.48	384.8	Cancer statistics, 2018.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2018	29313949	Yes
402	3273	3273.0	0.0	0.0	Some factors in the interpretation of protein denaturation.	W Kauzmann	Adv Protein Chem	1959	14404936	Yes
403	3269	3269.0	99.82	99.8	Protective and damaging effects of stress mediators.	B S McEwen	N Engl J Med	1998	9428819	No
404	6536	3268.0	190.43	95.2	Ab initio molecular dynamics for liquid metals.	Kresse, Hafner	Phys Rev B Condens Matter	1993	10004490	Yes
405	9800	3266.7	423.41	141.1	Cancer statistics, 2012.	Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal	CA Cancer J Clin	2012	22237781	Yes
406	13038	3259.5	305.77	76.4	Improved methods for building protein models in electron density maps and the location of errors in these models.	T A Jones, J Y Zou, S W Cowan, M Kjeldgaard	Acta Crystallogr A	1991	2025413	Yes
407	3256	3256.0	113.76	113.8	genepop'007: a complete re-implementation of the genepop software for Windows and Linux.	François Rousset	Mol Ecol Resour	2008	21585727	Yes
408	3249	3249.0	84.62	84.6	Biologic basis for interleukin-1 in disease.	C A Dinarello	Blood	1996	8630372	No
409	6490	3245.0	124.05	62.0	Translating the histone code.	T Jenuwein, C D Allis	Science	2001	11498575	No
410	3242	3242.0	128.78	128.8	A concordance correlation coefficient to evaluate reproducibility.	L I Lin	Biometrics	1989	2720055	Yes
411	3240	3240.0	109.27	109.3	Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence.	Ilan H Meyer	Psychol Bull	2003	12956539	No
412	3230	3230.0	115.61	115.6	How do you feel--now? The anterior insula and human awareness.	A D Bud Craig	Nat Rev Neurosci	2009	19096369	No
413	3229	3229.0	0.0	0.0	Estimation of average heterozygosity and genetic distance from a small number of individuals.	M Nei	Genetics	1978	17248844	Yes
414	6446	3223.0	0.0	0.0	Receptive fields, binocular interaction and functional architecture in the cat's visual cortex.	D H Hubel, T N Wiesel	J Physiol	1962	14449617	Yes
415	3221	3221.0	0.0	0.0	Observational study of behavior: sampling methods.	J Altmann	Behaviour	1974	4597405	No
416	3219	3219.0	128.86	128.9	Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine.	O W Griffith	Anal Biochem	1980	7416462	Yes
417	6436	3218.0	246.65	123.3	The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay.	I F Benzie, J J Strain	Anal Biochem	1996	8660627	Yes
418	3211	3211.0	87.97	88.0	The adolescent brain and age-related behavioral manifestations.	L P Spear	Neurosci Biobehav Rev	2000	10817843	No
419	3210	3210.0	92.98	93.0	Inositol trisphosphate and diacylglycerol: two interacting second messengers.	M J Berridge	Annu Rev Biochem	1987	3304132	No
420	3182	3182.0	77.07	77.1	Nonalcoholic fatty liver disease.	Paul Angulo	N Engl J Med	2002	11961152	No
421	3178	3178.0	0.0	0.0	Diffusion-in-gel methods for immunological analysis.	O Ouchterlony	Prog Allergy	1958	13578996	Yes
422	3176	3176.0	76.78	76.8	Glutamate uptake.	N C Danbolt	Prog Neurobiol	2001	11369436	No
423	9516	3172.0	582.05	194.0	Cancer statistics, 2015.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2015	25559415	Yes
424	3168	3168.0	87.85	87.8	Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?	Kim A Brogden	Nat Rev Microbiol	2005	15703760	No
425	3162	3162.0	96.46	96.5	Soft self-consistent pseudopotentials in a generalized eigenvalue formalism.	Vanderbilt	Phys Rev B Condens Matter	1990	9993096	Yes
426	3160	3160.0	79.44	79.4	The transforming growth factor-beta family.	J Massagué	Annu Rev Cell Biol	1990	2177343	No
427	3158	3158.0	0.0	0.0	Notes on sugar determination.	M Smogyi	J Biol Chem	1952	14938350	Yes
428	3151	3151.0	83.78	83.8	Oxidative stress, antioxidants and stress tolerance.	Ron Mittler	Trends Plant Sci	2002	12234732	No
429	3150	3150.0	0.0	0.0	Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.	S W Kessler	J Immunol	1975	1102604	Yes
430	6300	3150.0	165.71	82.9	An integrative theory of prefrontal cortex function.	E K Miller, J D Cohen	Annu Rev Neurosci	2001	11283309	No
431	3142	3142.0	68.1	68.1	Profile hidden Markov models.	S R Eddy	Bioinformatics	1998	9918945	No
432	12555	3138.8	539.33	134.8	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	Ann Intern Med	2009	19622511	No
433	3134	3134.0	85.17	85.2	ABC transporters: from microorganisms to man.	C F Higgins	Annu Rev Cell Biol	1992	1282354	No
434	3129	3129.0	73.39	73.4	Tolerance, danger, and the extended family.	P Matzinger	Annu Rev Immunol	1994	8011301	No
435	3127	3127.0	0.0	0.0	The magical number seven plus or minus two: some limits on our capacity for processing information.	G A Miller	Psychol Rev	1956	13310704	Yes
436	9364	3121.3	312.59	104.2	Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.	E R DeLong, D M DeLong, D L Clarke-Pearson	Biometrics	1988	3203132	Yes
437	3101	3101.0	101.02	101.0	Graphene: status and prospects.	A K Geim	Science	2009	19541989	Yes
438	3094	3094.0	104.03	104.0	Modeling valuations for EuroQol health states.	P Dolan	Med Care	1997	9366889	Yes
439	3094	3094.0	83.93	83.9	I-TASSER server for protein 3D structure prediction.	Yang Zhang	BMC Bioinformatics	2008	18215316	Yes
440	12368	3092.0	326.03	81.5	Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.	Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg	Genome Biol	2009	19261174	Yes
441	18550	3091.7	1171.98	195.3	Global cancer statistics, 2012.	Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin Jemal	CA Cancer J Clin	2015	25651787	Yes
442	6172	3086.0	0.0	0.0	Microsomal lipid peroxidation.	J A Buege, S D Aust	Methods Enzymol	1978	672633	Yes
443	9230	3076.7	385.88	128.6	A global measure of perceived stress.	S Cohen, T Kamarck, R Mermelstein	J Health Soc Behav	1983	6668417	Yes
444	3071	3071.0	64.08	64.1	CpG-rich islands and the function of DNA methylation.	A P Bird	Nature	1986	2423876	No
445	3067	3067.0	85.26	85.3	The origins and the future of microfluidics.	George M Whitesides	Nature	2006	16871203	No
446	3057	3057.0	62.34	62.3	STATs and gene regulation.	J E Darnell	Science	1997	9287210	No
447	3053	3053.0	58.71	58.7	Cell signaling by receptor tyrosine kinases.	J Schlessinger	Cell	2000	11057895	No
448	6105	3052.5	186.7	93.3	Velvet: algorithms for de novo short read assembly using de Bruijn graphs.	Daniel R Zerbino, Ewan Birney	Genome Res	2008	18349386	Yes
449	6102	3051.0	0.0	0.0	Human malaria parasites in continuous culture.	W Trager, J B Jensen	Science	1976	781840	Yes
450	3048	3048.0	68.86	68.9	Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.	H F Dvorak	N Engl J Med	1986	3537791	No
451	3044	3044.0	72.72	72.7	WHAT IF: a molecular modeling and drug design program.	G Vriend	J Mol Graph	1990	2268628	Yes
452	6079	3039.5	2125.56	1062.8	Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention.	Zunyou Wu, Jennifer M McGoogan	JAMA	2020	32091533	Yes
453	6070	3035.0	120.83	60.4	The ubiquitin system.	A Hershko, A Ciechanover	Annu Rev Biochem	1998	9759494	No
454	3034	3034.0	67.8	67.8	Activators and target genes of Rel/NF-kappaB transcription factors.	H L Pahl	Oncogene	1999	10602461	No
455	9084	3028.0	312.41	104.1	Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor.	R M Palmer, A G Ferrige, S Moncada	Nature	1987	3495737	Yes
456	3025	3025.0	0.0	0.0	Towards a network theory of the immune system.	N K Jerne	Ann Immunol (Paris)	1974	4142565	No
457	3018	3018.0	72.91	72.9	Folding DNA to create nanoscale shapes and patterns.	Paul W K Rothemund	Nature	2006	16541064	Yes
458	6017	3008.5	135.76	67.9	Angiogenesis in cancer and other diseases.	P Carmeliet, R K Jain	Nature	2000	11001068	No
459	6012	3006.0	127.59	63.8	Statistical significance for genomewide studies.	John D Storey, Robert Tibshirani	Proc Natl Acad Sci U S A	2003	12883005	Yes
460	2998	2998.0	0.0	0.0	A study of fixation for electron microscopy.	G E Palade	J Exp Med	1952	14927794	Yes
461	2991	2991.0	70.56	70.6	Cadherin cell adhesion receptors as a morphogenetic regulator.	M Takeichi	Science	1991	2006419	No
462	8964	2988.0	1625.38	541.8	Cancer statistics, 2019.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2019	30620402	Yes
463	2978	2978.0	73.92	73.9	Neural networks and physical systems with emergent collective computational abilities.	J J Hopfield	Proc Natl Acad Sci U S A	1982	6953413	Yes
464	2976	2976.0	74.06	74.1	Wound healing--aiming for perfect skin regeneration.	P Martin	Science	1997	9082989	No
465	2975	2975.0	0.0	0.0	A Rapid Permethylation Of Glycolipid, And Polysaccharide Catalyzed By Methylsulfinyl Carbanion In Dimethyl Sulfoxide.	S Hakomori	J Biochem	1964	14135466	Yes
466	2974	2974.0	74.54	74.5	Photoelectrochemical cells.	M Grätzel	Nature	2001	11713540	Yes
467	5942	2971.0	169.41	84.7	The basics of epithelial-mesenchymal transition.	Raghu Kalluri, Robert A Weinberg	J Clin Invest	2009	19487818	No
468	2966	2966.0	0.0	0.0	The gel-filtration behaviour of proteins related to their molecular weights over a wide range.	P Andrews	Biochem J	1965	5862401	Yes
469	2961	2961.0	97.14	97.1	Emerging adulthood. A theory of development from the late teens through the twenties.	J J Arnett	Am Psychol	2000	10842426	Yes
470	2955	2955.0	73.19	73.2	Phase separation of integral membrane proteins in Triton X-114 solution.	C Bordier	J Biol Chem	1981	6257680	Yes
471	2949	2949.0	82.44	82.4	Hay fever, hygiene, and household size.	D P Strachan	BMJ	1989	2513902	Yes
472	5896	2948.0	232.27	116.1	Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows.	Laurent Excoffier, Heidi E L Lischer	Mol Ecol Resour	2010	21565059	Yes
473	5895	2947.5	124.71	62.4	Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.	D B Smith, K S Johnson	Gene	1988	3047011	Yes
474	5892	2946.0	151.25	75.6	WGCNA: an R package for weighted correlation network analysis.	Peter Langfelder, Steve Horvath	BMC Bioinformatics	2008	19114008	Yes
475	2937	2937.0	85.81	85.8	EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis.	W Klimesch	Brain Res Brain Res Rev	1999	10209231	No
476	2936	2936.0	75.87	75.9	The basis of anisotropic water diffusion in the nervous system - a technical review.	Christian Beaulieu	NMR Biomed	2002	12489094	No
477	2925	2925.0	0.0	0.0	Gene action in the X-chromosome of the mouse (Mus musculus L.).	M F Lyon	Nature	1961	13764598	Yes
478	2924	2924.0	0.0	0.0	Transformed up-down methods in psychoacoustics.	H Levitt	J Acoust Soc Am	1971	5541744	Yes
479	2922	2922.0	78.9	78.9	The pathobiology of diabetic complications: a unifying mechanism.	Michael Brownlee	Diabetes	2005	15919781	No
480	2910	2910.0	0.0	0.0	Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid.	W C Schneider	J Biol Chem	1945	21005736	Yes
481	2909	2909.0	91.11	91.1	Matrix metalloproteinases and their inhibitors in connective tissue remodeling.	J F Woessner	FASEB J	1991	1850705	No
482	2908	2908.0	64.62	64.6	Mechanisms of angiogenesis and arteriogenesis.	P Carmeliet	Nat Med	2000	10742145	No
483	5815	2907.5	144.25	72.1	Inference of macromolecular assemblies from crystalline state.	Evgeny Krissinel, Kim Henrick	J Mol Biol	2007	17681537	Yes
484	8698	2899.3	243.24	81.1	Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.	Y Gavrieli, Y Sherman, S A Ben-Sasson	J Cell Biol	1992	1400587	Yes
485	2896	2896.0	0.0	0.0	Catheter replacement of the needle in percutaneous arteriography; a new technique.	S I Seldinger	Acta radiol	1953	13057644	Yes
486	20203	2886.1	476.82	68.1	UCSF Chimera--a visualization system for exploratory research and analysis.	Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin	J Comput Chem	2004	15264254	Yes
487	8658	2886.0	180.38	60.1	Significance analysis of microarrays applied to the ionizing radiation response.	V G Tusher, R Tibshirani, G Chu	Proc Natl Acad Sci U S A	2001	11309499	Yes
488	2881	2881.0	69.76	69.8	Chemokines--chemotactic cytokines that mediate inflammation.	A D Luster	N Engl J Med	1998	9459648	No
489	2871	2871.0	51.35	51.4	One-step gene disruption in yeast.	R J Rothstein	Methods Enzymol	1983	6310324	Yes
490	2869	2869.0	97.56	97.6	Functions of DNA methylation: islands, start sites, gene bodies and beyond.	Peter A Jones	Nat Rev Genet	2012	22641018	No
491	2866	2866.0	60.69	60.7	The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited.	Isaiah J Fidler	Nat Rev Cancer	2003	12778135	No
492	8596	2865.3	0.0	0.0	The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum.	R J Havel, H A Eder, J H Bragdon	J Clin Invest	1955	13252080	Yes
493	2865	2865.0	64.61	64.6	Angiogenesis in health and disease.	Peter Carmeliet	Nat Med	2003	12778163	No
494	5728	2864.0	229.28	114.6	Management of hepatocellular carcinoma: an update.	Jordi Bruix, Morris Sherman	Hepatology	2011	21374666	No
495	5726	2863.0	163.0	81.5	Inositol trisphosphate, a novel second messenger in cellular signal transduction.	M J Berridge, R F Irvine	Nature	1984	6095092	No
496	2859	2859.0	0.0	0.0	Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay.	B E Murphy	J Clin Endocrinol Metab	1967	4291524	Yes
497	2856	2856.0	74.92	74.9	How do you feel? Interoception: the sense of the physiological condition of the body.	A D Craig	Nat Rev Neurosci	2002	12154366	No
498	2854	2854.0	0.0	0.0	Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method.	L Svennerholm	Biochim Biophys Acta	1957	13436486	Yes
499	2850	2850.0	117.68	117.7	Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy.	T E Moffitt	Psychol Rev	1993	8255953	No
500	2847	2847.0	63.43	63.4	Protein folding and misfolding.	Christopher M Dobson	Nature	2003	14685248	No
501	8537	2845.7	0.0	0.0	Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane.	G Fairbanks, T L Steck, D F Wallach	Biochemistry	1971	4326772	Yes
502	2843	2843.0	89.75	89.8	Development of a classification system for periodontal diseases and conditions.	G C Armitage	Ann Periodontol	1999	10863370	No
503	5681	2840.5	0.0	0.0	Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain.	J Glowinski, L L Iversen	J Neurochem	1966	5950056	Yes
504	2839	2839.0	78.78	78.8	Mesenchymal stem cells.	A I Caplan	J Orthop Res	1991	1870029	Yes
505	5678	2839.0	128.95	64.5	Toll-like receptor signalling.	Shizuo Akira, Kiyoshi Takeda	Nat Rev Immunol	2004	15229469	No
506	5672	2836.0	137.21	68.6	Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase.	C Tuerk, L Gold	Science	1990	2200121	Yes
507	8507	2835.7	190.17	63.4	Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.	Benjamin P Lewis, Christopher B Burge, David P Bartel	Cell	2005	15652477	Yes
508	2827	2827.0	92.96	93.0	An empirical correction for absorption anisotropy.	R H Blessing	Acta Crystallogr A	1995	7702794	Yes
509	2823	2823.0	61.58	61.6	Alzheimer's disease is a synaptic failure.	Dennis J Selkoe	Science	2002	12399581	No
510	2821	2821.0	110.66	110.7	Half a century of research on the Stroop effect: an integrative review.	C M MacLeod	Psychol Bull	1991	2034749	No
511	2820	2820.0	72.42	72.4	Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies.	Ting-Chao Chou	Pharmacol Rev	2006	16968952	No
512	5638	2819.0	135.7	67.8	MicroRNA signatures in human cancers.	George A Calin, Carlo M Croce	Nat Rev Cancer	2006	17060945	No
513	2815	2815.0	0.0	0.0	A Generalized Wilcoxon Test For Comparing Arbitrarily Singly-Censored Samples.	E A Gehan	Biometrika	1965	14341275	Yes
514	5628	2814.0	0.0	0.0	Superoxide dismutase: improved assays and an assay applicable to acrylamide gels.	C Beauchamp, I Fridovich	Anal Biochem	1971	4943714	Yes
515	5628	2814.0	0.0	0.0	A method for determining the sedimentation behavior of enzymes: application to protein mixtures.	R G Martin, B N Ames	J Biol Chem	1961	13767412	Yes
516	5624	2812.0	146.11	73.1	The plant immune system.	Jonathan D G Jones, Jeffery L Dangl	Nature	2006	17108957	No
517	2811	2811.0	0.0	0.0	A study of the adrenotropic receptors.	R P Ahlquist	Am J Physiol	1948	18882199	Yes
518	2809	2809.0	54.97	55.0	RNA interference.	Gregory J Hannon	Nature	2002	12110901	No
519	5603	2801.5	111.6	55.8	High-efficiency transformation of mammalian cells by plasmid DNA.	C Chen, H Okayama	Mol Cell Biol	1987	3670292	Yes
520	2801	2801.0	162.73	162.7	Executive functions.	Adele Diamond	Annu Rev Psychol	2013	23020641	No
521	11201	2800.2	453.0	113.2	APACHE II: a severity of disease classification system.	W A Knaus, E A Draper, D P Wagner, J E Zimmerman	Crit Care Med	1985	3928249	Yes
522	2799	2799.0	83.14	83.1	Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis.	Thomas Welton	Chem Rev	1999	11849019	Yes
523	2797	2797.0	59.49	59.5	Principles of CDK regulation.	D O Morgan	Nature	1995	7877684	No
524	5584	2792.0	103.27	51.6	The language of covalent histone modifications.	B D Strahl, C D Allis	Nature	2000	10638745	Yes
525	11143	2785.8	0.0	0.0	Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.	P W Rigby, M Dieckmann, C Rhodes, P Berg	J Mol Biol	1977	881736	Yes
526	2783	2783.0	94.25	94.2	Role of oxidative stress in development of complications in diabetes.	J W Baynes	Diabetes	1991	2010041	No
527	5566	2783.0	152.77	76.4	The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers.	J Vieira, J Messing	Gene	1982	6295879	Yes
528	8340	2780.0	226.76	75.6	Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists.	Da Wei Huang, Brad T Sherman, Richard A Lempicki	Nucleic Acids Res	2009	19033363	Yes
529	5559	2779.5	0.0	0.0	Pain mechanisms: a new theory.	R Melzack, P D Wall	Science	1965	5320816	No
530	8330	2776.7	180.43	60.1	Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.	C M Gorman, L F Moffat, B H Howard	Mol Cell Biol	1982	6960240	Yes
531	11097	2774.2	281.86	70.5	Haploview: analysis and visualization of LD and haplotype maps.	J C Barrett, B Fry, J Maller, M J Daly	Bioinformatics	2005	15297300	Yes
532	5545	2772.5	0.0	0.0	Assessment of outcome after severe brain damage.	B Jennett, M Bond	Lancet	1975	46957	Yes
533	2769	2769.0	0.0	0.0	Efficient trace-labelling of proteins with iodine.	A S McFARLANE	Nature	1958	13566175	Yes
534	5534	2767.0	162.38	81.2	Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis.	S Duval, R Tweedie	Biometrics	2000	10877304	Yes
535	5532	2766.0	0.0	0.0	A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.	S Reitman, S Frankel	Am J Clin Pathol	1957	13458125	Yes
536	2765	2765.0	92.26	92.3	Health promotion by social cognitive means.	Albert Bandura	Health Educ Behav	2004	15090118	Yes
537	2762	2762.0	68.54	68.5	Obesity as a medical problem.	P G Kopelman	Nature	2000	10766250	No
538	5510	2755.0	0.0	0.0	The fluid mosaic model of the structure of cell membranes.	S J Singer, G L Nicolson	Science	1972	4333397	Yes
539	2754	2754.0	0.0	0.0	Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads.	P Cuatrecasas	J Biol Chem	1970	5432796	Yes
540	5505	2752.5	145.78	72.9	Voxel-based morphometry--the methods.	J Ashburner, K J Friston	Neuroimage	2000	10860804	No
541	2732	2732.0	83.87	83.9	Implications of normal brain development for the pathogenesis of schizophrenia.	D R Weinberger	Arch Gen Psychiatry	1987	3606332	Yes
542	5458	2729.0	162.02	81.0	Projections of global mortality and burden of disease from 2002 to 2030.	Colin D Mathers, Dejan Loncar	PLoS Med	2006	17132052	Yes
543	5448	2724.0	243.61	121.8	Revised methods for the Salmonella mutagenicity test.	D M Maron, B N Ames	Mutat Res	1983	6341825	Yes
544	2719	2719.0	96.31	96.3	The processing-speed theory of adult age differences in cognition.	T A Salthouse	Psychol Rev	1996	8759042	No
545	2717	2717.0	0.0	0.0	Measurement of pain.	E C Huskisson	Lancet	1974	4139420	Yes
546	2716	2716.0	126.26	126.3	The quality of care. How can it be assessed?	A Donabedian	JAMA	1988	3045356	No
547	5426	2713.0	127.93	64.0	Caspases: enemies within.	N A Thornberry, Y Lazebnik	Science	1998	9721091	No
548	2709	2709.0	66.4	66.4	Cell death during development of the nervous system.	R W Oppenheim	Annu Rev Neurosci	1991	2031577	No
549	2706	2706.0	91.71	91.7	Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report.	Sarah E Barlow	Pediatrics	2007	18055651	Yes
550	5408	2704.0	0.0	0.0	The serial cultivation of human diploid cell strains.	L Hayflick, P S Moorhead	Exp Cell Res	1961	13905658	Yes
551	5405	2702.5	131.46	65.7	Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.	T C Chou, P Talalay	Adv Enzyme Regul	1984	6382953	Yes
552	2701	2701.0	60.47	60.5	Cardiac excitation-contraction coupling.	Donald M Bers	Nature	2002	11805843	No
553	2700	2700.0	92.78	92.8	Hepatocellular carcinoma.	Hashem B El-Serag	N Engl J Med	2011	21992124	No
554	8083	2694.3	214.01	71.3	MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment.	Sudhir Kumar, Koichiro Tamura, Masatoshi Nei	Brief Bioinform	2004	15260895	Yes
555	2693	2693.0	60.98	61.0	Inflammatory bowel disease.	Daniel K Podolsky	N Engl J Med	2002	12167685	No
556	2693	2693.0	82.56	82.6	Drug combination studies and their synergy quantification using the Chou-Talalay method.	Ting-Chao Chou	Cancer Res	2010	20068163	Yes
557	2688	2688.0	71.3	71.3	Optimal two-stage designs for phase II clinical trials.	R Simon	Control Clin Trials	1989	2702835	Yes
558	2687	2687.0	72.83	72.8	Recent advances with liposomes as pharmaceutical carriers.	Vladimir P Torchilin	Nat Rev Drug Discov	2005	15688077	No
559	10748	2687.0	377.94	94.5	Cancer statistics, 2010.	Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth Ward	CA Cancer J Clin	2010	20610543	Yes
560	2682	2682.0	56.3	56.3	Toll-like receptors and innate immunity.	R Medzhitov	Nat Rev Immunol	2001	11905821	No
561	2678	2678.0	65.15	65.2	Mitochondrial formation of reactive oxygen species.	Julio F Turrens	J Physiol	2003	14561818	No
562	5355	2677.5	0.0	0.0	A modified uronic acid carbazole reaction.	T Bitter, H M Muir	Anal Biochem	1962	13971270	Yes
563	2676	2676.0	64.29	64.3	Structure and function of telomeres.	E H Blackburn	Nature	1991	1708110	No
564	2670	2670.0	63.94	63.9	Molecular chaperones in cellular protein folding.	F U Hartl	Nature	1996	8637592	No
565	5337	2668.5	127.31	63.7	Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes.	F W Studier, B A Moffatt	J Mol Biol	1986	3537305	Yes
566	8002	2667.3	390.4	130.1	HTSeq--a Python framework to work with high-throughput sequencing data.	Simon Anders, Paul Theodor Pyl, Wolfgang Huber	Bioinformatics	2015	25260700	Yes
567	2667	2667.0	76.78	76.8	Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection.	Y X Fu	Genetics	1997	9335623	Yes
568	2662	2662.0	52.25	52.2	Genome maintenance mechanisms for preventing cancer.	J H Hoeijmakers	Nature	2001	11357144	No
569	2662	2662.0	83.58	83.6	Non-coding RNAs in human disease.	Manel Esteller	Nat Rev Genet	2011	22094949	No
570	5323	2661.5	174.23	87.1	Tissue engineering.	R Langer, J P Vacanti	Science	1993	8493529	No
571	5301	2650.5	126.44	63.2	Oncomirs - microRNAs with a role in cancer.	Aurora Esquela-Kerscher, Frank J Slack	Nat Rev Cancer	2006	16557279	No
572	2647	2647.0	72.08	72.1	Origin and physiological roles of inflammation.	Ruslan Medzhitov	Nature	2008	18650913	No
573	2641	2641.0	0.0	0.0	Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism.	P Mitchell	Nature	1961	13771349	Yes
574	2639	2639.0	123.96	124.0	The short-form McGill Pain Questionnaire.	Ronald Melzack	Pain	1987	3670870	Yes
575	5275	2637.5	131.45	65.7	In vitro selection of RNA molecules that bind specific ligands.	A D Ellington, J W Szostak	Nature	1990	1697402	Yes
576	2637	2637.0	51.99	52.0	Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling.	P Schuck	Biophys J	2000	10692345	Yes
577	5255	2627.5	132.31	66.2	Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis.	D Hanahan, J Folkman	Cell	1996	8756718	No
578	2626	2626.0	85.96	86.0	Psychometric properties of the strengths and difficulties questionnaire.	R Goodman	J Am Acad Child Adolesc Psychiatry	2001	11699809	Yes
579	5249	2624.5	164.29	82.1	Glutathione.	A Meister, M E Anderson	Annu Rev Biochem	1983	6137189	No
580	5245	2622.5	0.0	0.0	Some quantitative uses of drug antagonists.	O Arunlakshana, H O Schild	Br J Pharmacol Chemother	1959	13651579	Yes
581	2622	2622.0	81.63	81.6	Primate models of movement disorders of basal ganglia origin.	M R DeLong	Trends Neurosci	1990	1695404	No
582	2622	2622.0	49.32	49.3	Wnt signaling and cancer.	P Polakis	Genes Dev	2000	10921899	No
583	2621	2621.0	0.0	0.0	A gene complex controlling segmentation in Drosophila.	E B Lewis	Nature	1978	103000	Yes
584	7858	2619.3	204.64	68.2	TopHat: discovering splice junctions with RNA-Seq.	Cole Trapnell, Lior Pachter, Steven L Salzberg	Bioinformatics	2009	19289445	Yes
585	2618	2618.0	0.0	0.0	Stereotaxic mapping of the monoamine pathways in the rat brain.	U Ungerstedt	Acta Physiol Scand Suppl	1971	4109331	Yes
586	2617	2617.0	0.0	0.0	The genetical structure of populations.	S Wright	Ann Eugen	1951	24540312	Yes
587	2614	2614.0	0.0	0.0	A simple technique for demonstrating centromeric heterochromatin.	A T Sumner	Exp Cell Res	1972	4117921	Yes
588	5228	2614.0	123.07	61.5	Oxidants, oxidative stress and the biology of ageing.	T Finkel, N J Holbrook	Nature	2000	11089981	No
589	5207	2603.5	179.83	89.9	Measuring agreement in method comparison studies.	J M Bland, D G Altman	Stat Methods Med Res	1999	10501650	No
590	10408	2602.0	230.19	57.5	Cluster analysis and display of genome-wide expression patterns.	M B Eisen, P T Spellman, P O Brown, D Botstein	Proc Natl Acad Sci U S A	1998	9843981	Yes
591	5193	2596.5	183.05	91.5	A simple, rapid, and sensitive DNA assay procedure.	C Labarca, K Paigen	Anal Biochem	1980	6158890	Yes
592	5191	2595.5	146.68	73.3	Fast and accurate long-read alignment with Burrows-Wheeler transform.	Heng Li, Richard Durbin	Bioinformatics	2010	20080505	Yes
593	2595	2595.0	0.0	0.0	The membrane actions of anesthetics and tranquilizers.	P Seeman	Pharmacol Rev	1972	4565956	No
594	2594	2594.0	81.52	81.5	Estimation of metabolite concentrations from localized in vivo proton NMR spectra.	S W Provencher	Magn Reson Med	1993	8139448	Yes
595	2586	2586.0	82.58	82.6	Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.	B Samuelsson	Science	1983	6301011	Yes
596	2581	2581.0	61.82	61.8	TGFbeta in Cancer.	Joan Massagué	Cell	2008	18662538	No
597	10321	2580.2	433.29	108.3	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	BMJ	2009	19622551	No
598	2577	2577.0	60.09	60.1	Nuclear factor-kappaB in cancer development and progression.	Michael Karin	Nature	2006	16724054	No
599	5148	2574.0	116.94	58.5	Signal transduction by receptors with tyrosine kinase activity.	A Ullrich, J Schlessinger	Cell	1990	2158859	No
600	5137	2568.5	186.03	93.0	A method of comparing the areas under receiver operating characteristic curves derived from the same cases.	J A Hanley, B J McNeil	Radiology	1983	6878708	Yes
601	2567	2567.0	84.89	84.9	No adjustments are needed for multiple comparisons.	K J Rothman	Epidemiology	1990	2081237	Yes
602	2565	2565.0	0.0	0.0	The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.	R R Porter	Biochem J	1959	14434282	Yes
603	2564	2564.0	0.0	0.0	The biology of oxygen radicals.	I Fridovich	Science	1978	210504	Yes
604	2564	2564.0	0.0	0.0	Analysis of gene diversity in subdivided populations.	M Nei	Proc Natl Acad Sci U S A	1973	4519626	Yes
605	2563	2563.0	59.57	59.6	Cell adhesion: the molecular basis of tissue architecture and morphogenesis.	B M Gumbiner	Cell	1996	8608588	No
606	5125	2562.5	105.7	52.9	Establishment in culture of pluripotential cells from mouse embryos.	M J Evans, M H Kaufman	Nature	1981	7242681	Yes
607	7683	2561.0	260.09	86.7	Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases.	R A Deyo, D C Cherkin, M A Ciol	J Clin Epidemiol	1992	1607900	Yes
608	2561	2561.0	45.67	45.7	Mechanisms underlying ubiquitination.	C M Pickart	Annu Rev Biochem	2001	11395416	No
609	2560	2560.0	64.34	64.3	The nerve growth factor 35 years later.	R Levi-Montalcini	Science	1987	3306916	No
610	5120	2560.0	189.75	94.9	Longitudinal data analysis for discrete and continuous outcomes.	S L Zeger, K Y Liang	Biometrics	1986	3719049	Yes
611	2558	2558.0	60.13	60.1	Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays.	S A Bustin	J Mol Endocrinol	2000	11013345	No
612	12778	2555.6	516.72	103.3	The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research.	D J Buysse, C F Reynolds, T H Monk, S R Berman, D J Kupfer	Psychiatry Res	1989	2748771	Yes
613	2554	2554.0	54.1	54.1	Papillomaviruses and cancer: from basic studies to clinical application.	Harald zur Hausen	Nat Rev Cancer	2002	12044010	No
614	2554	2554.0	0.0	0.0	Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults.	O Smithies	Biochem J	1955	13276348	Yes
615	5102	2551.0	0.0	0.0	Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.	L A Greene, A S Tischler	Proc Natl Acad Sci U S A	1976	1065897	Yes
616	7640	2546.7	214.3	71.4	Understanding the Warburg effect: the metabolic requirements of cell proliferation.	Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson	Science	2009	19460998	No
617	15270	2545.0	621.79	103.6	Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support.	Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G Conde	J Biomed Inform	2009	18929686	Yes
618	2544	2544.0	119.58	119.6	Detecting alcoholism. The CAGE questionnaire.	J A Ewing	JAMA	1984	6471323	Yes
619	2544	2544.0	89.0	89.0	Essential oils: their antibacterial properties and potential applications in foods--a review.	Sara Burt	Int J Food Microbiol	2004	15246235	No
620	2541	2541.0	53.6	53.6	Interleukin-12 and the regulation of innate resistance and adaptive immunity.	Giorgio Trinchieri	Nat Rev Immunol	2003	12563297	No
621	2541	2541.0	52.52	52.5	Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses.	Shimon Sakaguchi	Annu Rev Immunol	2004	15032588	No
622	2540	2540.0	55.13	55.1	G1 phase progression: cycling on cue.	C J Sherr	Cell	1994	7954821	No
623	2539	2539.0	62.88	62.9	Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity.	E C Butcher	Cell	1991	1760836	No
624	2532	2532.0	52.8	52.8	The danger model: a renewed sense of self.	Polly Matzinger	Science	2002	11951032	Yes
625	2531	2531.0	72.49	72.5	Delayed neuronal death in the gerbil hippocampus following ischemia.	T Kirino	Brain Res	1982	7093691	Yes
626	22752	2528.0	647.58	72.0	The Sequence Alignment/Map format and SAMtools.	Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin	Bioinformatics	2009	19505943	Yes
627	2517	2517.0	80.52	80.5	What are the functional consequences of neurocognitive deficits in schizophrenia?	M F Green	Am J Psychiatry	1996	8610818	No
628	5034	2517.0	111.46	55.7	Emergence of scaling in random networks	Barabasi, Albert	Science	1999	10521342	Yes
629	2507	2507.0	77.65	77.7	Secretory products of macrophages.	C F Nathan	J Clin Invest	1987	3543052	No
630	2503	2503.0	66.89	66.9	The resurgence of platinum-based cancer chemotherapy.	Lloyd Kelland	Nat Rev Cancer	2007	17625587	No
631	4999	2499.5	0.0	0.0	Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent.	J Sedlak, R H Lindsay	Anal Biochem	1968	4973948	Yes
632	4992	2496.0	105.09	52.5	Innate immune recognition.	Charles A Janeway, Ruslan Medzhitov	Annu Rev Immunol	2002	11861602	No
633	4990	2495.0	158.57	79.3	The L-arginine-nitric oxide pathway.	S Moncada, A Higgs	N Engl J Med	1993	7504210	No
634	2493	2493.0	67.47	67.5	Predictive reward signal of dopamine neurons.	W Schultz	J Neurophysiol	1998	9658025	No
635	4985	2492.5	156.54	78.3	Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees.	K Tamura, M Nei	Mol Biol Evol	1993	8336541	Yes
636	7472	2490.7	172.03	57.3	The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.	R C Lee, R L Feinbaum, V Ambros	Cell	1993	8252621	Yes
637	4979	2489.5	0.0	0.0	Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.	P J Fraker, J C Speck	Biochem Biophys Res Commun	1978	637870	Yes
638	4976	2488.0	0.0	0.0	A diagnostic interview: the schedule for affective disorders and schizophrenia.	J Endicott, R L Spitzer	Arch Gen Psychiatry	1978	678037	Yes
639	4976	2488.0	174.32	87.2	mTOR signaling in growth control and disease.	Mathieu Laplante, David M Sabatini	Cell	2012	22500797	No
640	2486	2486.0	50.76	50.8	Universal control mechanism regulating onset of M-phase.	P Nurse	Nature	1990	2138713	No
641	2486	2486.0	0.0	0.0	Elastic properties of lipid bilayers: theory and possible experiments.	W Helfrich	Z Naturforsch C	1973	4273690	Yes
642	4965	2482.5	0.0	0.0	The Social Readjustment Rating Scale.	T H Holmes, R H Rahe	J Psychosom Res	1967	6059863	Yes
643	4965	2482.5	151.31	75.7	The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.	Taro Kawai, Shizuo Akira	Nat Immunol	2010	20404851	No
644	2482	2482.0	0.0	0.0	On the number of segregating sites in genetical models without recombination.	G A Watterson	Theor Popul Biol	1975	1145509	Yes
645	2482	2482.0	60.33	60.3	Memory--a century of consolidation.	J L McGaugh	Science	2000	10634773	No
646	4950	2475.0	172.14	86.1	Computed tomography--an increasing source of radiation exposure.	David J Brenner, Eric J Hall	N Engl J Med	2007	18046031	No
647	2473	2473.0	0.0	0.0	Oxygen-dependent microbial killing by phagocytes (first of two parts).	B M Babior	N Engl J Med	1978	24176	Yes
648	2471	2471.0	0.0	0.0	The Estimation Of Pepsin, Trypsin, Papain, And Cathepsin With Hemoglobin.	M L Anson	J Gen Physiol	1938	19873094	Yes
649	2468	2468.0	0.0	0.0	The catecholamine hypothesis of affective disorders: a review of supporting evidence.	J J Schildkraut	Am J Psychiatry	1965	5319766	No
650	4930	2465.0	176.81	88.4	The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM.	Stephen B Edge, Carolyn C Compton	Ann Surg Oncol	2010	20180029	No
651	9852	2463.0	367.01	91.8	A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu.	Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge Krieg	J Chem Phys	2010	20423165	Yes
652	2461	2461.0	109.24	109.2	FreeSurfer.	Bruce Fischl	Neuroimage	2012	22248573	No
653	19676	2459.5	449.0	56.1	The Protein Data Bank.	H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E Bourne	Nucleic Acids Res	2000	10592235	Yes
654	2458	2458.0	0.0	0.0	The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes.	S Boyden	J Exp Med	1962	13872176	Yes
655	2451	2451.0	0.0	0.0	Models for the specific adhesion of cells to cells.	G I Bell	Science	1978	347575	No
656	2450	2450.0	58.24	58.2	Prostaglandins and leukotrienes: advances in eicosanoid biology.	C D Funk	Science	2001	11729303	No
657	4889	2444.5	132.66	66.3	Exploring the full spectrum of macrophage activation.	David M Mosser, Justin P Edwards	Nat Rev Immunol	2008	19029990	No
658	9737	2434.2	303.25	75.8	Establishing a standard definition for child overweight and obesity worldwide: international survey.	T J Cole, M C Bellizzi, K M Flegal, W H Dietz	BMJ	2000	10797032	Yes
659	7286	2428.7	286.74	95.6	Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups.	Allison Tong, Peter Sainsbury, Jonathan Craig	Int J Qual Health Care	2007	17872937	Yes
660	2428	2428.0	55.46	55.5	Social controls on cell survival and cell death.	M C Raff	Nature	1992	1557121	No
661	4847	2423.5	108.31	54.2	Inflammation and cancer: back to Virchow?	F Balkwill, A Mantovani	Lancet	2001	11229684	No
662	4835	2417.5	197.2	98.6	A feature-integration theory of attention.	A M Treisman, G Gelade	Cogn Psychol	1980	7351125	Yes
663	7251	2417.0	220.68	73.6	Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study.	G Evanno, S Regnaut, J Goudet	Mol Ecol	2005	15969739	Yes
664	2403	2403.0	0.0	0.0	Transduction of linked genetic characters of the host by bacteriophage P1.	E S Lennox	Virology	1955	13267987	Yes
665	2402	2402.0	88.5	88.5	Measures of reliability in sports medicine and science.	W G Hopkins	Sports Med	2000	10907753	Yes
666	4803	2401.5	145.62	72.8	Adherence to medication.	Lars Osterberg, Terrence Blaschke	N Engl J Med	2005	16079372	No
667	2400	2400.0	65.59	65.6	Dominant forces in protein folding.	K A Dill	Biochemistry	1990	2207096	No
668	2397	2397.0	54.28	54.3	Bone resorption by osteoclasts.	S L Teitelbaum	Science	2000	10968780	No
669	2394	2394.0	63.61	63.6	The genetic legacy of the Quaternary ice ages.	G Hewitt	Nature	2000	10879524	No
670	2391	2391.0	92.63	92.6	Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM.	Joseph P Weir	J Strength Cond Res	2005	15705040	No
671	2387	2387.0	0.0	0.0	Perceived exertion as an indicator of somatic stress.	G Borg	Scand J Rehabil Med	1970	5523831	Yes
672	4773	2386.5	115.59	57.8	Calculation of protein extinction coefficients from amino acid sequence data.	S C Gill, P H von Hippel	Anal Biochem	1989	2610349	Yes
673	2386	2386.0	65.4	65.4	Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication.	H G Gratzner	Science	1982	7123245	Yes
674	4771	2385.5	0.0	0.0	Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years.	J V Durnin, J Womersley	Br J Nutr	1974	4843734	Yes
675	4770	2385.0	156.95	78.5	Complex brain networks: graph theoretical analysis of structural and functional systems.	Ed Bullmore, Olaf Sporns	Nat Rev Neurosci	2009	19190637	No
676	4768	2384.0	0.0	0.0	Electrochemical photolysis of water at a semiconductor electrode.	A Fujishima, K Honda	Nature	1972	12635268	Yes
677	2382	2382.0	0.0	0.0	Satellite cell of skeletal muscle fibers.	A Mauro	J Biophys Biochem Cytol	1961	13768451	Yes
678	2381	2381.0	67.68	67.7	Cellular and molecular mechanisms of fibrosis.	T A Wynn	J Pathol	2008	18161745	No
679	2368	2368.0	0.0	0.0	Electroimmuno assay.	C B Laurell	Scand J Clin Lab Invest Suppl	1972	4114358	Yes
680	4729	2364.5	157.27	78.6	The neural basis of drug craving: an incentive-sensitization theory of addiction.	T E Robinson, K C Berridge	Brain Res Brain Res Rev	1993	8401595	No
681	2364	2364.0	0.0	0.0	A rapid radiochemical method for the determination of choline acetyltransferase.	F Fonnum	J Neurochem	1975	1113118	Yes
682	7086	2362.0	177.05	59.0	Pathogen recognition and innate immunity.	Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi	Cell	2006	16497588	No
683	2359	2359.0	57.79	57.8	Vascular endothelial growth factor: basic science and clinical progress.	Napoleone Ferrara	Endocr Rev	2004	15294883	No
684	9429	2357.2	496.67	124.2	Cancer statistics, 2014.	Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin Jemal	CA Cancer J Clin	2014	24399786	Yes
685	2355	2355.0	0.0	0.0	Colorimetric assay of catalase.	A K Sinha	Anal Biochem	1972	4556490	Yes
686	2354	2354.0	91.34	91.3	You want to measure coping but your protocol's too long: consider the brief COPE.	C S Carver	Int J Behav Med	1997	16250744	Yes
687	4699	2349.5	94.67	47.3	CDK inhibitors: positive and negative regulators of G1-phase progression.	C J Sherr, J M Roberts	Genes Dev	1999	10385618	No
688	4695	2347.5	0.0	0.0	Screening lambdagt recombinant clones by hybridization to single plaques in situ.	W D Benton, R W Davis	Science	1977	322279	Yes
689	4691	2345.5	96.84	48.4	Untangling the ErbB signalling network.	Y Yarden, M X Sliwkowski	Nat Rev Mol Cell Biol	2001	11252954	No
690	4689	2344.5	0.0	0.0	Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase.	S Marklund, G Marklund	Eur J Biochem	1974	4215654	Yes
691	4689	2344.5	133.99	67.0	Unified segmentation.	John Ashburner, Karl J Friston	Neuroimage	2005	15955494	Yes
692	2343	2343.0	57.35	57.4	Autophagy: process and function.	Noboru Mizushima	Genes Dev	2007	18006683	No
693	2343	2343.0	57.82	57.8	Epigenetics in cancer.	Manel Esteller	N Engl J Med	2008	18337604	No
694	4679	2339.5	0.0	0.0	A general method applicable to the search for similarities in the amino acid sequence of two proteins.	S B Needleman, C D Wunsch	J Mol Biol	1970	5420325	Yes
695	2339	2339.0	61.59	61.6	Cancer nanotechnology: opportunities and challenges.	Mauro Ferrari	Nat Rev Cancer	2005	15738981	No
696	2329	2329.0	0.0	0.0	The glomerular permeability determined by dextran clearance using Sephadex gel filtration.	C E Mogensen	Scand J Clin Lab Invest	1968	5637478	Yes
697	2328	2328.0	55.97	56.0	Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface.	G P Smith	Science	1985	4001944	Yes
698	4650	2325.0	0.0	0.0	Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography.	R A Laskey, A D Mills	Eur J Biochem	1975	1175627	Yes
699	2317	2317.0	85.99	86.0	Calmodulin plays a pivotal role in cellular regulation.	W Y Cheung	Science	1980	6243188	No
700	2316	2316.0	45.52	45.5	Getting started with yeast.	F Sherman	Methods Enzymol	1991	2005794	Yes
701	2316	2316.0	0.0	0.0	Application of a microtechnique to viral serological investigations.	J L Sever	J Immunol	1962	13910995	Yes
702	4625	2312.5	0.0	0.0	Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid.	J D Watson, F H Crick	Nature	1953	13054692	Yes
703	2311	2311.0	53.81	53.8	Salt and drought stress signal transduction in plants.	Jian-Kang Zhu	Annu Rev Plant Biol	2002	12221975	No
704	4619	2309.5	118.82	59.4	Autophagy in the pathogenesis of disease.	Beth Levine, Guido Kroemer	Cell	2008	18191218	No
705	2304	2304.0	51.35	51.4	Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling.	T Hunter	Cell	1995	7834742	No
706	4607	2303.5	0.0	0.0	Periodontal Disease In Pregnancy. Ii. Correlation Between Oral Hygiene And Periodontal Condtion.	J Silness, H Loe	Acta Odontol Scand	1964	14158464	Yes
707	2299	2299.0	0.0	0.0	The Michigan alcoholism screening test: the quest for a new diagnostic instrument.	M L Selzer	Am J Psychiatry	1971	5565851	Yes
708	2299	2299.0	53.74	53.7	A decade of molecular biology of retinoic acid receptors.	P Chambon	FASEB J	1996	8801176	No
709	4597	2298.5	99.75	49.9	MicroRNAs: small RNAs with a big role in gene regulation.	Lin He, Gregory J Hannon	Nat Rev Genet	2004	15211354	No
710	2298	2298.0	54.12	54.1	Angiogenesis in life, disease and medicine.	Peter Carmeliet	Nature	2005	16355210	No
711	2297	2297.0	0.0	0.0	Inositol phospholipids and cell surface receptor function.	R H Michell	Biochim Biophys Acta	1975	164246	No
712	2290	2290.0	66.37	66.4	Interleukin-1 and interleukin-1 antagonism.	C A Dinarello	Blood	1991	1826616	No
713	2290	2290.0	57.39	57.4	Bcl-2 and the regulation of programmed cell death.	J C Reed	J Cell Biol	1994	8294493	No
714	2290	2290.0	71.03	71.0	RELION: implementation of a Bayesian approach to cryo-EM structure determination.	Sjors H W Scheres	J Struct Biol	2012	23000701	Yes
715	2289	2289.0	51.47	51.5	The structure and regulation of protein phosphatases.	P Cohen	Annu Rev Biochem	1989	2549856	No
716	2289	2289.0	89.47	89.5	What is value in health care?	Michael E Porter	N Engl J Med	2010	21142528	Yes
717	4572	2286.0	104.59	52.3	Death receptors: signaling and modulation.	A Ashkenazi, V M Dixit	Science	1998	9721089	No
718	2286	2286.0	0.0	0.0	Muscle structure and theories of contraction.	A F Huxley	Prog Biophys Biophys Chem	1957	13485191	Yes
719	4562	2281.0	0.0	0.0	High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.	M N Berry, D S Friend	J Cell Biol	1969	4900611	Yes
720	4549	2274.5	234.6	117.3	GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update.	Rod Peakall, Peter E Smouse	Bioinformatics	2012	22820204	Yes
721	2269	2269.0	50.11	50.1	Evolving concepts of rheumatoid arthritis.	Gary S Firestein	Nature	2003	12748655	No
722	4535	2267.5	207.68	103.8	The qualitative content analysis process.	Satu Elo, Helvi Kyngäs	J Adv Nurs	2008	18352969	Yes
723	2265	2265.0	45.71	45.7	SV40-transformed simian cells support the replication of early SV40 mutants.	Y Gluzman	Cell	1981	6260373	Yes
724	2265	2265.0	62.43	62.4	The magical number 4 in short-term memory: a reconsideration of mental storage capacity.	N Cowan	Behav Brain Sci	2001	11515286	Yes
725	2262	2262.0	0.0	0.0	Separation of leukocytes from blood and bone marrow. Introduction.	A Böyum	Scand J Clin Lab Invest Suppl	1968	5707208	Yes
726	2258	2258.0	66.29	66.3	Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention.	P Correa	Cancer Res	1992	1458460	No
727	2255	2255.0	76.55	76.5	Glutamate, nitric oxide and cell-cell signalling in the nervous system.	J Garthwaite	Trends Neurosci	1991	1708538	No
728	4489	2244.5	103.07	51.5	A simple and very efficient method for generating cDNA libraries.	U Gubler, B J Hoffman	Gene	1983	6198242	Yes
729	2244	2244.0	94.79	94.8	Qualitative research. Introducing focus groups.	J Kitzinger	BMJ	1995	7633241	Yes
730	6731	2243.7	135.04	45.0	Gene Expression Omnibus: NCBI gene expression and hybridization array data repository.	Ron Edgar, Michael Domrachev, Alex E Lash	Nucleic Acids Res	2002	11752295	Yes
731	2243	2243.0	0.0	0.0	Stereochemistry of cooperative effects in haemoglobin.	M F Perutz	Nature	1970	5528785	Yes
732	6723	2241.0	0.0	0.0	On The Nature Of Allosteric Transitions: A Plausible Model.	J Monod, J Wyman, J P Changeux	J Mol Biol	1965	14343300	Yes
733	2239	2239.0	55.94	55.9	Calcium signaling.	David E Clapham	Cell	2007	18083096	No
734	4473	2236.5	93.77	46.9	Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.	D Bonnet, J E Dick	Nat Med	1997	9212098	Yes
735	4473	2236.5	161.37	80.7	Complex network measures of brain connectivity: uses and interpretations.	Mikail Rubinov, Olaf Sporns	Neuroimage	2010	19819337	Yes
736	2236	2236.0	0.0	0.0	Evaluating the quality of medical care.	A Donabedian	Milbank Mem Fund Q	1966	5338568	No
737	2236	2236.0	94.57	94.6	The Danish Civil Registration System.	Carsten Bøcker Pedersen	Scand J Public Health	2011	21775345	Yes
738	4471	2235.5	90.99	45.5	The phosphatidylinositol 3-Kinase AKT pathway in human cancer.	Igor Vivanco, Charles L Sawyers	Nat Rev Cancer	2002	12094235	No
739	4466	2233.0	91.92	46.0	Lipid rafts and signal transduction.	K Simons, D Toomre	Nat Rev Mol Cell Biol	2000	11413487	No
740	4464	2232.0	139.84	69.9	Rapid isolation of high molecular weight plant DNA.	M G Murray, W F Thompson	Nucleic Acids Res	1980	7433111	Yes
741	4459	2229.5	84.66	42.3	A novel genetic system to detect protein-protein interactions.	S Fields, O Song	Nature	1989	2547163	Yes
742	2229	2229.0	51.55	51.5	Mitochondrial diseases in man and mouse.	D C Wallace	Science	1999	10066162	No
743	4455	2227.5	0.0	0.0	The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin.	J A Spudich, S Watt	J Biol Chem	1971	4254541	Yes
744	2227	2227.0	46.99	47.0	Tumour-educated macrophages promote tumour progression and metastasis.	Jeffrey W Pollard	Nat Rev Cancer	2004	14708027	No
745	2223	2223.0	55.13	55.1	Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose.	J Kyhse-Andersen	J Biochem Biophys Methods	1984	6530509	Yes
746	4446	2223.0	123.5	61.8	Management of hepatocellular carcinoma.	Jordi Bruix, Morris Sherman	Hepatology	2005	16250051	No
747	2221	2221.0	0.0	0.0	Removal of fatty acids from serum albumin by charcoal treatment.	R F Chen	J Biol Chem	1967	6016603	Yes
748	2221	2221.0	55.37	55.4	MapChart: software for the graphical presentation of linkage maps and QTLs.	R E Voorrips	J Hered	2002	12011185	Yes
749	2219	2219.0	56.03	56.0	A model for receptor-regulated calcium entry.	J W Putney	Cell Calcium	1986	2420465	No
750	4435	2217.5	99.57	49.8	Organization and expression of eucaryotic split genes coding for proteins.	R Breathnach, P Chambon	Annu Rev Biochem	1981	6791577	No
751	2216	2216.0	0.0	0.0	Mechanisms of action of transmitters and other substances on smooth muscle.	T B Bolton	Physiol Rev	1979	37533	No
752	2216	2216.0	53.39	53.4	Mechanisms and genes of cellular suicide.	H Steller	Science	1995	7878463	No
753	2212	2212.0	50.13	50.1	Chemokines and leukocyte traffic.	M Baggiolini	Nature	1998	9560152	No
754	2212	2212.0	0.0	0.0	The information capacity of the human motor system in controlling the amplitude of movement.	P M Fitts	J Exp Psychol	1954	13174710	Yes
755	2210	2210.0	70.99	71.0	Reactive oxygen species and the central nervous system.	B Halliwell	J Neurochem	1992	1402908	No
756	2209	2209.0	85.44	85.4	Role of endothelium in responses of vascular smooth muscle.	R F Furchgott	Circ Res	1983	6313250	No
757	4417	2208.5	116.47	58.2	Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences.	Weizhong Li, Adam Godzik	Bioinformatics	2006	16731699	Yes
758	2208	2208.0	59.0	59.0	A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.	P Chomczynski	Biotechniques	1993	7692896	Yes
759	2206	2206.0	53.54	53.5	Protein kinase C and lipid signaling for sustained cellular responses.	Y Nishizuka	FASEB J	1995	7737456	No
760	2204	2204.0	75.61	75.6	Accelerated Profile HMM Searches.	Sean R Eddy	PLoS Comput Biol	2011	22039361	Yes
761	4405	2202.5	120.92	60.5	Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology.	Marie-Christine Daniel, Didier Astruc	Chem Rev	2004	14719978	No
762	2201	2201.0	61.71	61.7	Molecular diversity of glutamate receptors and implications for brain function.	S Nakanishi	Science	1992	1329206	No
763	2201	2201.0	78.68	78.7	Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases.	B N Ames	Science	1983	6351251	No
764	2198	2198.0	0.0	0.0	The plasma lecithins:cholesterol acyltransferase reaction.	J A Glomset	J Lipid Res	1968	4868699	No
765	2198	2198.0	49.18	49.2	Molecular physiology of P2X receptors.	R Alan North	Physiol Rev	2002	12270951	No
766	2198	2198.0	58.51	58.5	Causes and consequences of microRNA dysregulation in cancer.	Carlo M Croce	Nat Rev Genet	2009	19763153	No
767	4393	2196.5	0.0	0.0	The interpretation of protein structures: estimation of static accessibility.	B Lee, F M Richards	J Mol Biol	1971	5551392	Yes
768	2195	2195.0	70.17	70.2	SF-36 health survey update.	J E Ware	Spine (Phila Pa 1976)	2000	11124729	No
769	4386	2193.0	0.0	0.0	On the size of the active site in proteases. I. Papain.	I Schechter, A Berger	Biochem Biophys Res Commun	1967	6035483	Yes
770	2192	2192.0	0.0	0.0	[Rapid physiological coagulation method in determination of fibrinogen].	A Clauss	Acta Haematol	1957	13434757	Yes
771	4369	2184.5	115.44	57.7	A receptor-mediated pathway for cholesterol homeostasis.	M S Brown, J L Goldstein	Science	1986	3513311	No
772	2182	2182.0	65.54	65.5	Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century.	M Leavitt	MedGenMed	2001	11549951	No
773	2181	2181.0	68.07	68.1	Prooxidant states and tumor promotion.	P A Cerutti	Science	1985	2981433	No
774	6540	2180.0	364.39	121.5	Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition.	P J Van Soest, J B Robertson, B A Lewis	J Dairy Sci	1991	1660498	No
775	4359	2179.5	0.0	0.0	A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.	J E TILL, E A McCULLOCH	Radiat Res	1961	13776896	Yes
776	2179	2179.0	68.12	68.1	Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.	R A DeFronzo	Diabetes	1988	3289989	No
777	2175	2175.0	0.0	0.0	A new specific color reaction of hexuronic acids.	Z Dische	J Biol Chem	1947	20281638	Yes
778	4345	2172.5	0.0	0.0	Periodontal Disease In Pregnancy. I. Prevalence And Severity.	H Loe, J Silness	Acta Odontol Scand	1963	14121956	Yes
779	2172	2172.0	79.26	79.3	A computational approach to edge detection.	J Canny	IEEE Trans Pattern Anal Mach Intell	1986	21869365	Yes
780	4335	2167.5	148.31	74.2	Random-effects models for longitudinal data.	N M Laird, J H Ware	Biometrics	1982	7168798	Yes
781	4334	2167.0	95.5	47.8	New functions for the matrix metalloproteinases in cancer progression.	Mikala Egeblad, Zena Werb	Nat Rev Cancer	2002	11990853	No
782	2167	2167.0	71.72	71.7	adegenet: a R package for the multivariate analysis of genetic markers.	Thibaut Jombart	Bioinformatics	2008	18397895	Yes
783	2166	2166.0	56.05	56.0	Molecular basis of bacterial outer membrane permeability revisited.	Hiroshi Nikaido	Microbiol Mol Biol Rev	2003	14665678	No
784	2163	2163.0	53.77	53.8	Ischemic cell death in brain neurons.	P Lipton	Physiol Rev	1999	10508238	No
785	4323	2161.5	218.57	109.3	Stress, social support, and the buffering hypothesis.	S Cohen, T A Wills	Psychol Bull	1985	3901065	No
786	4314	2157.0	128.75	64.4	Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9167458	Yes
787	2156	2156.0	48.46	48.5	The regulation of AP-1 activity by mitogen-activated protein kinases.	M Karin	J Biol Chem	1995	7622446	No
788	2154	2154.0	0.0	0.0	Sedimentation Studies Of The Size And Shape Of Dna.	F W Studier	J Mol Biol	1965	14290352	Yes
789	2153	2153.0	49.31	49.3	Chemokines.	B J Rollins	Blood	1997	9242519	No
790	2153	2153.0	65.05	65.0	Two-sided confidence intervals for the single proportion: comparison of seven methods.	R G Newcombe	Stat Med	1998	9595616	Yes
791	6451	2150.3	210.58	70.2	Arlequin (version 3.0): an integrated software package for population genetics data analysis.	Laurent Excoffier, Guillaume Laval, Stefan Schneider	Evol Bioinform Online	2007	19325852	Yes
792	2150	2150.0	79.83	79.8	Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals.	H W Steinbusch	Neuroscience	1981	7017455	Yes
793	2147	2147.0	66.27	66.3	Diagnosis of Alzheimer's disease.	Z S Khachaturian	Arch Neurol	1985	2864910	Yes
794	2143	2143.0	0.0	0.0	The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations.	W W Cleland	Biochim Biophys Acta	1963	14021667	Yes
795	4284	2142.0	95.85	47.9	Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.	F Sallusto, A Lanzavecchia	J Exp Med	1994	8145033	Yes
796	2142	2142.0	42.0	42.0	Java Treeview--extensible visualization of microarray data.	Alok J Saldanha	Bioinformatics	2004	15180930	Yes
797	4274	2137.0	0.0	0.0	The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase.	H P Misra, I Fridovich	J Biol Chem	1972	4623845	Yes
798	4274	2137.0	131.08	65.5	Neural mechanisms of selective visual attention.	R Desimone, J Duncan	Annu Rev Neurosci	1995	7605061	No
799	4274	2137.0	99.65	49.8	The Bcl-2 protein family: arbiters of cell survival.	J M Adams, S Cory	Science	1998	9735050	No
800	2135	2135.0	57.68	57.7	Dietary pattern analysis: a new direction in nutritional epidemiology.	Frank B Hu	Curr Opin Lipidol	2002	11790957	No
801	12805	2134.2	317.42	52.9	Phaser crystallographic software.	Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J Read	J Appl Crystallogr	2007	19461840	Yes
802	4267	2133.5	139.11	69.6	Accurate and simple analytic representation of the electron-gas correlation energy.	Perdew, Wang	Phys Rev B Condens Matter	1992	10001404	Yes
803	6399	2133.0	150.79	50.3	The biology of VEGF and its receptors.	Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter	Nat Med	2003	12778165	No
804	2131	2131.0	0.0	0.0	A Rationale And Test For The Number Of Factors In Factor Analysis.	J L Horn	Psychometrika	1965	14306381	Yes
805	2130	2130.0	85.82	85.8	Effective physician-patient communication and health outcomes: a review.	M A Stewart	CMAJ	1995	7728691	Yes
806	4253	2126.5	116.73	58.4	Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up.	C W Elston, I O Ellis	Histopathology	1991	1757079	Yes
807	4251	2125.5	0.0	0.0	A Simplified Lead Citrate Stain For Use In Electron Microscopy.	J H Venable, R Coggeshall	J Cell Biol	1965	14287192	Yes
808	4244	2122.0	126.63	63.3	Pattern recognition receptors and inflammation.	Osamu Takeuchi, Shizuo Akira	Cell	2010	20303872	No
809	2121	2121.0	42.03	42.0	Protein modules and signalling networks.	T Pawson	Nature	1995	7531822	No
810	2120	2120.0	63.92	63.9	Scaffolds in tissue engineering bone and cartilage.	D W Hutmacher	Biomaterials	2000	11071603	Yes
811	2119	2119.0	0.0	0.0	Intracellular aspects of the process of protein synthesis.	G Palade	Science	1975	1096303	No
812	2119	2119.0	40.98	41.0	Histone acetylation in chromatin structure and transcription.	M Grunstein	Nature	1997	9311776	No
813	4231	2115.5	194.38	97.2	Clinical significance: a statistical approach to defining meaningful change in psychotherapy research.	N S Jacobson, P Truax	J Consult Clin Psychol	1991	2002127	Yes
814	2112	2112.0	49.65	49.6	A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine.	Douglas C Wallace	Annu Rev Genet	2005	16285865	No
815	2111	2111.0	41.21	41.2	Targeting RAS signalling pathways in cancer therapy.	Julian Downward	Nat Rev Cancer	2003	12509763	No
816	2110	2110.0	0.0	0.0	Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids.	D Aminoff	Biochem J	1961	13860975	Yes
817	2109	2109.0	46.16	46.2	Telomere measurement by quantitative PCR.	Richard M Cawthon	Nucleic Acids Res	2002	12000852	Yes
818	6317	2105.7	188.87	63.0	Bacterial biofilms: a common cause of persistent infections.	J W Costerton, P S Stewart, E P Greenberg	Science	1999	10334980	No
819	4208	2104.0	106.74	53.4	Function and activation of NF-kappa B in the immune system.	P A Baeuerle, T Henkel	Annu Rev Immunol	1994	8011280	No
820	8406	2101.5	276.51	69.1	Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy.	Qiong Wang, George M Garrity, James M Tiedje, James R Cole	Appl Environ Microbiol	2007	17586664	Yes
821	2101	2101.0	79.84	79.8	Specific impairments of planning.	T Shallice	Philos Trans R Soc Lond B Biol Sci	1982	6125971	Yes
822	2100	2100.0	50.1	50.1	Patterns of amino acids near signal-sequence cleavage sites.	G von Heijne	Eur J Biochem	1983	6852022	Yes
823	4199	2099.5	105.3	52.6	Regulation of the mevalonate pathway.	J L Goldstein, M S Brown	Nature	1990	1967820	No
824	2098	2098.0	88.34	88.3	A systematic method for clinical description and classification of personality variants. A proposal.	C R Cloninger	Arch Gen Psychiatry	1987	3579504	Yes
825	2098	2098.0	116.12	116.1	Interrater reliability: the kappa statistic.	Mary L McHugh	Biochem Med (Zagreb)	2012	23092060	Yes
826	4193	2096.5	94.61	47.3	Mass spectrometry-based proteomics.	Ruedi Aebersold, Matthias Mann	Nature	2003	12634793	No
827	4191	2095.5	100.11	50.1	Assembly of asparagine-linked oligosaccharides.	R Kornfeld, S Kornfeld	Annu Rev Biochem	1985	3896128	No
828	4191	2095.5	165.41	82.7	FLASH: fast length adjustment of short reads to improve genome assemblies.	Tanja Magoč, Steven L Salzberg	Bioinformatics	2011	21903629	Yes
829	4189	2094.5	0.0	0.0	Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method.	R B Devereux, N Reichek	Circulation	1977	138494	Yes
830	4189	2094.5	102.15	51.1	Signal integration in the endoplasmic reticulum unfolded protein response.	David Ron, Peter Walter	Nat Rev Mol Cell Biol	2007	17565364	No
831	2091	2091.0	50.1	50.1	Specification of cerebral cortical areas.	P Rakic	Science	1988	3291116	No
832	2090	2090.0	0.0	0.0	The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers.	D E Atkinson	Biochemistry	1968	4972613	Yes
833	8349	2087.2	246.0	61.5	GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation.	Berk Hess, Carsten Kutzner, David van der Spoel, Erik Lindahl	J Chem Theory Comput	2008	26620784	Yes
834	2087	2087.0	49.43	49.4	Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity.	G Trinchieri	Annu Rev Immunol	1995	7612223	No
835	4174	2087.0	85.81	42.9	Mechanisms of TGF-beta signaling from cell membrane to the nucleus.	Yigong Shi, Joan Massagué	Cell	2003	12809600	No
836	4171	2085.5	122.63	61.3	Distributed hierarchical processing in the primate cerebral cortex.	D J Felleman, D C Van Essen	Cereb Cortex	1991	1822724	No
837	4169	2084.5	0.0	0.0	Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.	T V Bliss, T Lomo	J Physiol	1973	4727084	Yes
838	4165	2082.5	148.75	74.4	The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions.	S H Downs, N Black	J Epidemiol Community Health	1998	9764259	Yes
839	2082	2082.0	44.68	44.7	Mammalian G1 cyclins.	C J Sherr	Cell	1993	8513492	No
840	4163	2081.5	154.16	77.1	The attention system of the human brain.	M I Posner, S E Petersen	Annu Rev Neurosci	1990	2183676	No
841	4162	2081.0	120.62	60.3	Angiogenic factors.	J Folkman, M Klagsbrun	Science	1987	2432664	No
842	2080	2080.0	46.99	47.0	NOX enzymes and the biology of reactive oxygen.	J David Lambeth	Nat Rev Immunol	2004	15039755	No
843	6239	2079.7	285.02	95.0	Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale.	J L Cox, J M Holden, R Sagovsky	Br J Psychiatry	1987	3651732	Yes
844	2079	2079.0	63.67	63.7	Physiology and neurobiology of stress and adaptation: central role of the brain.	Bruce S McEwen	Physiol Rev	2007	17615391	No
845	2076	2076.0	0.0	0.0	Method For Assay Of Intestinal Disaccharidases.	A Dahlqvist	Anal Biochem	1964	14106916	Yes
846	6227	2075.7	0.0	0.0	Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.	B N Ames, J Mccann, E Yamasaki	Mutat Res	1975	768755	Yes
847	4146	2073.0	107.53	53.8	Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results.	E Lander, L Kruglyak	Nat Genet	1995	7581446	Yes
848	16584	2073.0	541.0	67.6	The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.	D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C Siebert	N Engl J Med	1993	8366922	Yes
849	4146	2073.0	123.09	61.5	Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly.	J S Beckman, W H Koppenol	Am J Physiol	1996	8944624	No
850	2072	2072.0	43.14	43.1	The molecular biology of memory storage: a dialogue between genes and synapses.	E R Kandel	Science	2001	11691980	No
851	2068	2068.0	52.61	52.6	Modularity and community structure in networks.	M E J Newman	Proc Natl Acad Sci U S A	2006	16723398	Yes
852	4135	2067.5	434.4	217.2	A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research.	Terry K Koo, Mae Y Li	J Chiropr Med	2016	27330520	Yes
853	2065	2065.0	122.57	122.6	Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs.	Daniël Lakens	Front Psychol	2013	24324449	No
854	2064	2064.0	0.0	0.0	Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters.	F F Jöbsis	Science	1977	929199	Yes
855	2063	2063.0	0.0	0.0	Enzymatic Basis For Active Transport Of Na+ And K+ Across Cell Membrane.	J C Skou	Physiol Rev	1965	14337569	No
856	2062	2062.0	0.0	0.0	Selection Of Hybrids From Matings Of Fibroblasts In Vitro And Their Presumed Recombinants.	J W Littlefield	Science	1964	14168277	Yes
857	2060	2060.0	63.2	63.2	The unbiased estimation of number and sizes of arbitrary particles using the disector.	D C Sterio	J Microsc	1984	6737468	Yes
858	6178	2059.3	366.78	122.3	Deep learning.	Yann LeCun, Yoshua Bengio, Geoffrey Hinton	Nature	2015	26017442	No
859	6176	2058.7	145.22	48.4	MOLMOL: a program for display and analysis of macromolecular structures.	R Koradi, M Billeter, K Wüthrich	J Mol Graph	1996	8744573	Yes
860	2056	2056.0	53.89	53.9	Breast cancer and hormone-replacement therapy in the Million Women Study.	Valerie Beral	Lancet	2003	12927427	Yes
861	2055	2055.0	57.88	57.9	Immunological and inflammatory functions of the interleukin-1 family.	Charles A Dinarello	Annu Rev Immunol	2009	19302047	No
862	4108	2054.0	157.74	78.9	Self-rated health and mortality: a review of twenty-seven community studies.	E L Idler, Y Benyamini	J Health Soc Behav	1997	9097506	No
863	4107	2053.5	87.65	43.8	A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.	G Shaw, R Kamen	Cell	1986	3488815	Yes
864	2053	2053.0	51.16	51.2	The anatomy and taxonomy of protein structure.	J S Richardson	Adv Protein Chem	1981	7020376	No
865	2049	2049.0	53.67	53.7	A mechanism for cognitive dynamics: neuronal communication through neuronal coherence.	Pascal Fries	Trends Cogn Sci	2005	16150631	No
866	2049	2049.0	0.0	0.0	Isolation by Distance.	S Wright	Genetics	1943	17247074	Yes
867	2048	2048.0	45.8	45.8	Cisplatin: mode of cytotoxic action and molecular basis of resistance.	Zahid H Siddik	Oncogene	2003	14576837	No
868	4096	2048.0	108.32	54.2	Reactive oxygen species: metabolism, oxidative stress, and signal transduction.	Klaus Apel, Heribert Hirt	Annu Rev Plant Biol	2004	15377225	No
869	4095	2047.5	0.0	0.0	Plaque formation and isolation of pure lines with poliomyelitis viruses.	R Dulbecco, M Vogt	J Exp Med	1954	13130792	Yes
870	6142	2047.3	181.19	60.4	Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.	C E Murry, R B Jennings, K A Reimer	Circulation	1986	3769170	Yes
871	2044	2044.0	63.22	63.2	A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data.	Heng Li	Bioinformatics	2011	21903627	Yes
872	4076	2038.0	104.11	52.1	Protein misfolding, functional amyloid, and human disease.	Fabrizio Chiti, Christopher M Dobson	Annu Rev Biochem	2006	16756495	No
873	2036	2036.0	0.0	0.0	Mechanism Of Sustained-Action Medication. Theoretical Analysis Of Rate Of Release Of Solid Drugs Dispersed In Solid Matrices.	T Higuchi	J Pharm Sci	1963	14088963	Yes
874	2034	2034.0	42.57	42.6	G1 events and regulation of cell proliferation.	A B Pardee	Science	1989	2683075	No
875	6100	2033.3	0.0	0.0	Immunochemical quantitation of antigens by single radial immunodiffusion.	G Mancini, A O Carbonara, J F Heremans	Immunochemistry	1965	4956917	Yes
876	4066	2033.0	128.19	64.1	Missing data: our view of the state of the art.	Joseph L Schafer, John W Graham	Psychol Methods	2002	12090408	Yes
877	4060	2030.0	98.18	49.1	AKT/PKB signaling: navigating downstream.	Brendan D Manning, Lewis C Cantley	Cell	2007	17604717	No
878	4057	2028.5	100.19	50.1	Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction.	P Liang, A B Pardee	Science	1992	1354393	Yes
879	6081	2027.0	171.47	57.2	RNA-Seq: a revolutionary tool for transcriptomics.	Zhong Wang, Mark Gerstein, Michael Snyder	Nat Rev Genet	2009	19015660	No
880	2025	2025.0	0.0	0.0	Antigen-antibody reactions in gels.	O Ouchterlony	Acta Pathol Microbiol Scand	1949	18143039	Yes
881	4048	2024.0	107.08	53.5	Acute-phase proteins and other systemic responses to inflammation.	C Gabay, I Kushner	N Engl J Med	1999	9971870	No
882	2022	2022.0	0.0	0.0	Analysis of bacteriophage T7 early RNAs and proteins on slab gels.	F W Studier	J Mol Biol	1973	4760132	Yes
883	6063	2021.0	0.0	0.0	Glucose clamp technique: a method for quantifying insulin secretion and resistance.	R A DeFronzo, J D Tobin, R Andres	Am J Physiol	1979	382871	Yes
884	2021	2021.0	69.04	69.0	A classification of glycosyl hydrolases based on amino acid sequence similarities.	B Henrissat	Biochem J	1991	1747104	Yes
885	2021	2021.0	52.07	52.1	RGD and other recognition sequences for integrins.	E Ruoslahti	Annu Rev Cell Dev Biol	1996	8970741	No
886	2021	2021.0	70.4	70.4	Ethical authorship and publishing.	Andrew J S Coats	Int J Cardiol	2009	19046787	No
887	2019	2019.0	83.0	83.0	A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992.	E L Bradley	Arch Surg	1993	8489394	No
888	2017	2017.0	59.34	59.3	ATP-regulated K+ channels in cardiac muscle.	A Noma	Nature	1983	6310409	Yes
889	2016	2016.0	48.05	48.0	Interleukin-2: inception, impact, and implications.	K A Smith	Science	1988	3131876	No
890	4018	2009.0	81.17	40.6	The fundamental role of epigenetic events in cancer.	Peter A Jones, Stephen B Baylin	Nat Rev Genet	2002	12042769	No
891	4016	2008.0	208.31	104.2	phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data.	Paul J McMurdie, Susan Holmes	PLoS One	2013	23630581	Yes
892	4014	2007.0	105.0	52.5	A global optimisation method for robust affine registration of brain images.	M Jenkinson, S Smith	Med Image Anal	2001	11516708	Yes
893	2005	2005.0	44.31	44.3	The mitogen-activated protein kinase signal transduction pathway.	R J Davis	J Biol Chem	1993	8325833	No
894	2004	2004.0	57.08	57.1	Superoxide radical and superoxide dismutases.	I Fridovich	Annu Rev Biochem	1995	7574505	No
895	2002	2002.0	44.54	44.5	Structural design and molecular evolution of a cytokine receptor superfamily.	J F Bazan	Proc Natl Acad Sci U S A	1990	2169613	Yes
896	2002	2002.0	67.2	67.2	Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men.	W A Craig	Clin Infect Dis	1998	9455502	No
897	2002	2002.0	43.16	43.2	Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self.	Shimon Sakaguchi	Nat Immunol	2005	15785760	No
898	5997	1999.0	178.52	59.5	Quantum mechanical continuum solvation models.	Jacopo Tomasi, Benedetta Mennucci, Roberto Cammi	Chem Rev	2005	16092826	Yes
899	1999	1999.0	63.27	63.3	Parkinson's disease: clinical features and diagnosis.	J Jankovic	J Neurol Neurosurg Psychiatry	2008	18344392	No
900	1998	1998.0	45.23	45.2	Nitric oxide and the immune response.	C Bogdan	Nat Immunol	2001	11577346	No
901	1998	1998.0	67.16	67.2	Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples.	Peter C Austin	Stat Med	2009	19757444	Yes
902	1997	1997.0	67.67	67.7	Working memory.	A Baddeley	Science	1992	1736359	No
903	1994	1994.0	60.3	60.3	Stress, adaptation, and disease. Allostasis and allostatic load.	B S McEwen	Ann N Y Acad Sci	1998	9629234	No
904	1993	1993.0	47.83	47.8	Calcium signaling.	D E Clapham	Cell	1995	7834745	No
905	1993	1993.0	42.91	42.9	XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density.	D E McRee	J Struct Biol	1999	10222271	Yes
906	1993	1993.0	76.12	76.1	DNA methylation age of human tissues and cell types.	Steve Horvath	Genome Biol	2013	24138928	Yes
907	1991	1991.0	0.0	0.0	The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis.	U E Loening	Biochem J	1967	5339944	Yes
908	3980	1990.0	132.59	66.3	Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being.	R M Ryan, E L Deci	Am Psychol	2000	11392867	Yes
909	1989	1989.0	94.29	94.3	Structural Model Evaluation and Modification: An Interval Estimation Approach.	J H Steiger	Multivariate Behav Res	1990	26794479	Yes
910	1988	1988.0	0.0	0.0	Presidential Address-1976. Social support as a moderator of life stress.	S Cobb	Psychosom Med	1976	981490	Yes
911	3975	1987.5	109.29	54.6	The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.	Karen Bedard, Karl-Heinz Krause	Physiol Rev	2007	17237347	No
912	1986	1986.0	0.0	0.0	Chemiosmotic coupling in oxidative and photosynthetic phosphorylation.	P Mitchell	Biol Rev Camb Philos Soc	1966	5329743	No
913	1986	1986.0	45.14	45.1	Complement. First of two parts.	M J Walport	N Engl J Med	2001	11287977	No
914	3970	1985.0	80.09	40.0	Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.	M Gossen, H Bujard	Proc Natl Acad Sci U S A	1992	1319065	Yes
915	3970	1985.0	108.89	54.4	New perspectives in cell adhesion: RGD and integrins.	E Ruoslahti, M D Pierschbacher	Science	1987	2821619	No
916	1984	1984.0	53.66	53.7	The molecular pathology of Alzheimer's disease.	D J Selkoe	Neuron	1991	1673054	No
917	1982	1982.0	83.0	83.0	Role of Streptococcus mutans in human dental decay.	W J Loesche	Microbiol Rev	1986	3540569	No
918	3962	1981.0	0.0	0.0	Loss of recent memory after bilateral hippocampal lesions.	W B Scoville, B Milner	J Neurol Neurosurg Psychiatry	1957	13406589	Yes
919	3958	1979.0	127.05	63.5	SPSS and SAS procedures for estimating indirect effects in simple mediation models.	Kristopher J Preacher, Andrew F Hayes	Behav Res Methods Instrum Comput	2004	15641418	Yes
920	1977	1977.0	53.13	53.1	The heme oxygenase system: a regulator of second messenger gases.	M D Maines	Annu Rev Pharmacol Toxicol	1997	9131263	No
921	1975	1975.0	66.88	66.9	Biodiesel from microalgae.	Yusuf Chisti	Biotechnol Adv	2007	17350212	No
922	1973	1973.0	58.69	58.7	Formation and Structure of Self-Assembled Monolayers.	Abraham Ulman	Chem Rev	1996	11848802	Yes
923	1969	1969.0	62.56	62.6	Hybrid porous solids: past, present, future.	Gérard Férey	Chem Soc Rev	2008	18197340	Yes
924	3937	1968.5	104.06	52.0	The heat-shock proteins.	S Lindquist, E A Craig	Annu Rev Genet	1988	2853609	No
925	3937	1968.5	0.0	0.0	Preparation Of Fatty Acid Methyl Esters And Dimethylacetals From Lipids With Boron Fluoride--Methanol.	W R Morrison, L M Smith	J Lipid Res	1964	14221106	Yes
926	1968	1968.0	48.11	48.1	The inflammatory reflex.	Kevin J Tracey	Nature	2002	12490958	No
927	3935	1967.5	104.61	52.3	Myeloid-derived suppressor cells as regulators of the immune system.	Dmitry I Gabrilovich, Srinivas Nagaraj	Nat Rev Immunol	2009	19197294	No
928	3929	1964.5	112.11	56.1	A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.	Y Matsumura, H Maeda	Cancer Res	1986	2946403	Yes
929	1961	1961.0	57.9	57.9	Protein oxidation and aging.	E R Stadtman	Science	1992	1355616	No
930	1959	1959.0	53.7	53.7	Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis.	J Folkman	N Engl J Med	1995	7491141	No
931	5877	1959.0	163.32	54.4	ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data.	Kai Wang, Mingyao Li, Hakon Hakonarson	Nucleic Acids Res	2010	20601685	Yes
932	1957	1957.0	0.0	0.0	Purinergic nerves.	G Burnstock	Pharmacol Rev	1972	4404211	No
933	5867	1955.7	121.5	40.5	Rapid and efficient site-specific mutagenesis without phenotypic selection.	T A Kunkel, J D Roberts, R A Zakour	Methods Enzymol	1987	3323813	Yes
934	3910	1955.0	0.0	0.0	Genetic regulatory mechanisms in the synthesis of proteins.	F Jacob, J Monod	J Mol Biol	1961	13718526	Yes
935	1954	1954.0	0.0	0.0	The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera.	S V Boyden	J Exp Med	1951	14803635	Yes
936	1953	1953.0	65.34	65.3	Eye movements in reading and information processing: 20 years of research.	K Rayner	Psychol Bull	1998	9849112	No
937	3906	1953.0	0.0	0.0	A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase.	R F Beers, I W Sizer	J Biol Chem	1952	14938361	Yes
938	3902	1951.0	100.44	50.2	Nonparametric permutation tests for functional neuroimaging: a primer with examples.	Thomas E Nichols, Andrew P Holmes	Hum Brain Mapp	2002	11747097	Yes
939	1951	1951.0	61.53	61.5	Efficient methods to compute genomic predictions.	P M VanRaden	J Dairy Sci	2008	18946147	Yes
940	1949	1949.0	55.19	55.2	The importance of selenium to human health.	M P Rayman	Lancet	2000	10963212	No
941	1949	1949.0	58.7	58.7	Pancreatic cancer.	Manuel Hidalgo	N Engl J Med	2010	20427809	No
942	3894	1947.0	116.18	58.1	Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging.	Michael D Fox, Marcus E Raichle	Nat Rev Neurosci	2007	17704812	No
943	1946	1946.0	39.48	39.5	Shelterin: the protein complex that shapes and safeguards human telomeres.	Titia de Lange	Genes Dev	2005	16166375	No
944	1945	1945.0	39.42	39.4	NK cell recognition.	Lewis L Lanier	Annu Rev Immunol	2005	15771571	No
945	1944	1944.0	61.3	61.3	Fetal origins of coronary heart disease.	D J Barker	BMJ	1995	7613432	No
946	1943	1943.0	52.72	52.7	Descending control of pain.	Mark J Millan	Prog Neurobiol	2002	12034378	No
947	1942	1942.0	0.0	0.0	Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle.	A Fleckenstein	Annu Rev Pharmacol Toxicol	1977	326161	No
948	1942	1942.0	0.0	0.0	Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate.	J P Chamberlain	Anal Biochem	1979	543547	Yes
949	1942	1942.0	0.0	0.0	The oxidation of ribonuclease with performic acid.	C H Hirs	J Biol Chem	1956	13319283	Yes
950	1940	1940.0	54.35	54.4	The biology of interleukin-6.	T Kishimoto	Blood	1989	2473791	No
951	1940	1940.0	0.0	0.0	Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli.	G Bertani	J Bacteriol	1951	14888646	Yes
952	1940	1940.0	90.15	90.2	Central sensitization: implications for the diagnosis and treatment of pain.	Clifford J Woolf	Pain	2011	20961685	No
953	1939	1939.0	40.35	40.4	Mechanisms of intracellular protein transport.	J E Rothman	Nature	1994	7969419	No
954	1938	1938.0	69.64	69.6	Determination of glutathione and glutathione disulfide in biological samples.	M E Anderson	Methods Enzymol	1985	4088074	Yes
955	3876	1938.0	95.91	48.0	Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.	G G Glenner, C W Wong	Biochem Biophys Res Commun	1984	6375662	Yes
956	3870	1935.0	0.0	0.0	Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy.	I W McLean, P K Nakane	J Histochem Cytochem	1974	4374474	Yes
957	3866	1933.0	80.64	40.3	Mammalian MAP kinase signalling cascades.	L Chang, M Karin	Nature	2001	11242034	No
958	1932	1932.0	66.3	66.3	Human error: models and management.	J Reason	BMJ	2000	10720363	Yes
959	1931	1931.0	52.92	52.9	Working memory: looking back and looking forward.	Alan Baddeley	Nat Rev Neurosci	2003	14523382	No
960	1931	1931.0	47.85	47.9	Rab GTPases as coordinators of vesicle traffic.	Harald Stenmark	Nat Rev Mol Cell Biol	2009	19603039	No
961	1930	1930.0	56.4	56.4	Estimating causal effects from large data sets using propensity scores.	D B Rubin	Ann Intern Med	1997	9382394	No
962	1929	1929.0	57.74	57.7	Intracellular calcium homeostasis.	E Carafoli	Annu Rev Biochem	1987	3304139	No
963	1927	1927.0	49.75	49.8	Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences.	Edward V Loftus	Gastroenterology	2004	15168363	Yes
964	11551	1925.2	265.52	44.3	NMRPipe: a multidimensional spectral processing system based on UNIX pipes.	F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A Bax	J Biomol NMR	1995	8520220	Yes
965	3849	1924.5	108.46	54.2	Insulin-like growth factors and their binding proteins: biological actions.	J I Jones, D R Clemmons	Endocr Rev	1995	7758431	No
966	1924	1924.0	46.67	46.7	Pathways towards and away from Alzheimer's disease.	Mark P Mattson	Nature	2004	15295589	No
967	3846	1923.0	125.91	63.0	A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.	Gary J Bennett, Y-K Xie	Pain	1988	2837713	Yes
968	3844	1922.0	92.38	46.2	Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.	B A Reynolds, S Weiss	Science	1992	1553558	Yes
969	5766	1922.0	116.48	38.8	Control of regulatory T cell development by the transcription factor Foxp3.	Shohei Hori, Takashi Nomura, Shimon Sakaguchi	Science	2003	12522256	Yes
970	3843	1921.5	84.92	42.5	Lessons from hereditary colorectal cancer.	K W Kinzler, B Vogelstein	Cell	1996	8861899	No
971	1921	1921.0	35.54	35.5	ATM and related protein kinases: safeguarding genome integrity.	Yosef Shiloh	Nat Rev Cancer	2003	12612651	No
972	3841	1920.5	101.36	50.7	Hepatocellular carcinoma: epidemiology and molecular carcinogenesis.	Hashem B El-Serag, K Lenhard Rudolph	Gastroenterology	2007	17570226	No
973	1920	1920.0	0.0	0.0	Crystalline Soybean Trypsin Inhibitor : Ii. General Properties.	M Kunitz	J Gen Physiol	1947	19873496	Yes
974	1919	1919.0	63.73	63.7	Spinal and supraspinal factors in human muscle fatigue.	S C Gandevia	Physiol Rev	2001	11581501	No
975	3838	1919.0	0.0	0.0	Acetylornithinase of Escherichia coli: partial purification and some properties.	H J Vogel, D M Bonner	J Biol Chem	1956	13278318	Yes
976	3838	1919.0	0.0	0.0	Judgment under Uncertainty: Heuristics and Biases.	A Tversky, D Kahneman	Science	1974	17835457	Yes
977	3836	1918.0	0.0	0.0	Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid.	A C Chang, S N Cohen	J Bacteriol	1978	149110	Yes
978	1918	1918.0	40.74	40.7	A cell culture model for T lymphocyte clonal anergy.	R H Schwartz	Science	1990	2113314	Yes
979	1917	1917.0	35.53	35.5	In situ hybridization: an improved whole-mount method for Xenopus embryos.	R M Harland	Methods Cell Biol	1991	1811161	Yes
980	1917	1917.0	59.94	59.9	A two process model of sleep regulation.	A A Borbély	Hum Neurobiol	1982	7185792	Yes
981	1916	1916.0	41.43	41.4	Role of angiogenesis in tumor growth and metastasis.	Judah Folkman	Semin Oncol	2002	12516034	No
982	3830	1915.0	84.15	42.1	The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.	A J Ridley, A Hall	Cell	1992	1643657	Yes
983	1912	1912.0	64.66	64.7	Plant products as antimicrobial agents.	M M Cowan	Clin Microbiol Rev	1999	10515903	No
984	1912	1912.0	39.51	39.5	CpG motifs in bacterial DNA and their immune effects.	Arthur M Krieg	Annu Rev Immunol	2002	11861616	No
985	1912	1912.0	50.23	50.2	Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens.	Jane Glazebrook	Annu Rev Phytopathol	2005	16078883	No
986	11471	1911.8	411.48	68.6	Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.	Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell Parkin	Int J Cancer	2010	21351269	Yes
987	1911	1911.0	74.31	74.3	Epidemiology of viral hepatitis and hepatocellular carcinoma.	Hashem B El-Serag	Gastroenterology	2012	22537432	No
988	3821	1910.5	178.89	89.4	Stages and processes of self-change of smoking: toward an integrative model of change.	J O Prochaska, C C DiClemente	J Consult Clin Psychol	1983	6863699	Yes
989	1910	1910.0	47.12	47.1	DNA topoisomerases.	J C Wang	Annu Rev Biochem	1985	2992360	No
990	3819	1909.5	118.07	59.0	The number of people with glaucoma worldwide in 2010 and 2020.	H A Quigley, A T Broman	Br J Ophthalmol	2006	16488940	Yes
991	3817	1908.5	105.99	53.0	Alzheimer's disease: the amyloid cascade hypothesis.	J A Hardy, G A Higgins	Science	1992	1566067	No
992	1908	1908.0	64.86	64.9	Intermediate filaments as mechanical integrators of cellular space.	E Lazarides	Nature	1980	7188712	Yes
993	1908	1908.0	71.23	71.2	International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results.	C Herrmann	J Psychosom Res	1997	9055211	No
994	1908	1908.0	49.96	50.0	Inferring the historical patterns of biological evolution.	M Pagel	Nature	1999	10553904	Yes
995	1907	1907.0	0.0	0.0	Influences of glucose loading and of injected insulin on hepatic glucose output.	R Steele	Ann N Y Acad Sci	1959	13833973	Yes
996	1905	1905.0	0.0	0.0	Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system.	D M Neville	J Biol Chem	1971	5127429	Yes
997	1904	1904.0	50.94	50.9	DNA topoisomerase poisons as antitumor drugs.	L F Liu	Annu Rev Biochem	1989	2549853	No
998	1899	1899.0	81.05	81.0	A rating scale for drug-induced akathisia.	T R Barnes	Br J Psychiatry	1989	2574607	Yes
999	1899	1899.0	80.88	80.9	The validity and practicality of sun-reactive skin types I through VI.	T B Fitzpatrick	Arch Dermatol	1988	3377516	Yes
1000	5695	1898.3	224.12	74.7	Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA.	G Muyzer, E C de Waal, A G Uitterlinden	Appl Environ Microbiol	1993	7683183	Yes
1001	5695	1898.3	153.51	51.2	Cortical surface-based analysis. I. Segmentation and surface reconstruction.	A M Dale, B Fischl, M I Sereno	Neuroimage	1999	9931268	Yes
1002	3796	1898.0	102.87	51.4	Inositol phosphates and cell signalling.	M J Berridge, R F Irvine	Nature	1989	2550825	No
1003	3796	1898.0	101.45	50.7	Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.	M Matsuda, R A DeFronzo	Diabetes Care	1999	10480510	Yes
1004	1897	1897.0	85.43	85.4	The Children's Depression, Inventory (CDI).	M Kovacs	Psychopharmacol Bull	1985	4089116	Yes
1005	1897	1897.0	84.51	84.5	Brain dopamine receptors.	P Seeman	Pharmacol Rev	1980	6117090	No
1006	1895	1895.0	0.0	0.0	Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma.	A Breslow	Ann Surg	1970	5477666	Yes
1007	1895	1895.0	0.0	0.0	Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?	J V Neel	Am J Hum Genet	1962	13937884	Yes
1008	3789	1894.5	106.85	53.4	UniFrac: a new phylogenetic method for comparing microbial communities.	Catherine Lozupone, Rob Knight	Appl Environ Microbiol	2005	16332807	Yes
1009	1893	1893.0	0.0	0.0	In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain.	T R Chen	Exp Cell Res	1977	65285	Yes
1010	5675	1891.7	192.7	64.2	Parallel organization of functionally segregated circuits linking basal ganglia and cortex.	G E Alexander, M R DeLong, P L Strick	Annu Rev Neurosci	1986	3085570	No
1011	1891	1891.0	0.0	0.0	On estimating the relation between blood group and disease.	B Woolf	Ann Hum Genet	1955	14388528	Yes
1012	1891	1891.0	57.25	57.2	Carbonic anhydrases: novel therapeutic applications for inhibitors and activators.	Claudiu T Supuran	Nat Rev Drug Discov	2008	18167490	No
1013	1886	1886.0	0.0	0.0	Analysis of tissue and arterial blood temperatures in the resting human forearm.	H H Pennes	J Appl Physiol	1948	18887578	Yes
1014	5657	1885.7	172.0	57.3	Immunity, inflammation, and cancer.	Sergei I Grivennikov, Florian R Greten, Michael Karin	Cell	2010	20303878	No
1015	3769	1884.5	95.76	47.9	Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.	P J Barnes, M Karin	N Engl J Med	1997	9091804	No
1016	1884	1884.0	42.84	42.8	Signal sequences. The limits of variation.	G von Heijne	J Mol Biol	1985	4032478	Yes
1017	7532	1883.0	173.17	43.3	Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.	A Krogh, B Larsson, G von Heijne, E L Sonnhammer	J Mol Biol	2001	11152613	Yes
1018	1883	1883.0	65.56	65.6	The unfolded protein response: controlling cell fate decisions under ER stress and beyond.	Claudio Hetz	Nat Rev Mol Cell Biol	2012	22251901	No
1019	3765	1882.5	90.16	45.1	Base-calling of automated sequencer traces using phred. II. Error probabilities.	B Ewing, P Green	Genome Res	1998	9521922	Yes
1020	1882	1882.0	0.0	0.0	Complete nucleotide sequence of the Escherichia coli plasmid pBR322.	J G Sutcliffe	Cold Spring Harb Symp Quant Biol	1979	383387	Yes
1021	1882	1882.0	56.97	57.0	Calbindin D-28k and parvalbumin in the rat nervous system.	M R Celio	Neuroscience	1990	2199841	Yes
1022	5645	1881.7	0.0	0.0	Research diagnostic criteria: rationale and reliability.	R L Spitzer, J Endicott, E Robins	Arch Gen Psychiatry	1978	655775	Yes
1023	1881	1881.0	0.0	0.0	A modified card sorting test sensitive to frontal lobe defects.	H E Nelson	Cortex	1976	1009768	Yes
1024	3762	1881.0	78.39	39.2	Network biology: understanding the cell's functional organization.	Albert-László Barabási, Zoltán N Oltvai	Nat Rev Genet	2004	14735121	No
1025	3761	1880.5	0.0	0.0	Variations in pattern of pubertal changes in girls.	W A Marshall, J M Tanner	Arch Dis Child	1969	5785179	Yes
1026	3760	1880.0	0.0	0.0	An efficient mRNA-dependent translation system from reticulocyte lysates.	H R Pelham, R J Jackson	Eur J Biochem	1976	823012	Yes
1027	3760	1880.0	93.45	46.7	Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.	M Nei, T Gojobori	Mol Biol Evol	1986	3444411	Yes
1028	1879	1879.0	53.0	53.0	T cell exhaustion.	E John Wherry	Nat Immunol	2011	21739672	No
1029	1878	1878.0	54.79	54.8	Excitotoxic cell death.	D W Choi	J Neurobiol	1992	1361523	No
1030	1877	1877.0	65.65	65.7	Simplified calculation of body-surface area.	R D Mosteller	N Engl J Med	1987	3657876	Yes
1031	1875	1875.0	40.15	40.1	Molecular bases for circadian clocks.	J C Dunlap	Cell	1999	9988221	No
1032	1874	1874.0	82.36	82.4	Missing data analysis: making it work in the real world.	John W Graham	Annu Rev Psychol	2009	18652544	No
1033	1873	1873.0	34.88	34.9	Signaling--2000 and beyond.	T Hunter	Cell	2000	10647936	No
1034	1873	1873.0	39.22	39.2	Mechanisms of type-I- and type-II-interferon-mediated signalling.	Leonidas C Platanias	Nat Rev Immunol	2005	15864272	No
1035	1870	1870.0	41.84	41.8	Biology of natural killer cells.	G Trinchieri	Adv Immunol	1989	2683611	No
1036	1870	1870.0	64.69	64.7	Qualitative research: standards, challenges, and guidelines.	K Malterud	Lancet	2001	11513933	Yes
1037	1868	1868.0	0.0	0.0	Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal.	S Cohen	J Biol Chem	1962	13880319	Yes
1038	7470	1867.5	188.13	47.0	p53 mutations in human cancers.	M Hollstein, D Sidransky, B Vogelstein, C C Harris	Science	1991	1905840	No
1039	5601	1867.0	141.22	47.1	GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants.	R A Jefferson, T A Kavanagh, M W Bevan	EMBO J	1987	3327686	Yes
1040	3727	1863.5	87.25	43.6	The Fas death factor.	S Nagata, P Golstein	Science	1995	7533326	No
1041	1863	1863.0	55.11	55.1	Japanese Classification of Gastric Carcinoma - 2nd English Edition -	Japanese Gastric Cancer Association	Gastric Cancer	1998	11957040	Yes
1042	3723	1861.5	108.42	54.2	Application of phylogenetic networks in evolutionary studies.	Daniel H Huson, David Bryant	Mol Biol Evol	2006	16221896	Yes
1043	1859	1859.0	74.65	74.7	Approximate entropy as a measure of system complexity.	S M Pincus	Proc Natl Acad Sci U S A	1991	11607165	Yes
1044	1858	1858.0	48.69	48.7	Flow-mediated endothelial mechanotransduction.	P F Davies	Physiol Rev	1995	7624393	No
1045	3716	1858.0	96.4	48.2	Leptin and the regulation of body weight in mammals.	J M Friedman, J L Halaas	Nature	1998	9796811	No
1046	1857	1857.0	39.74	39.7	Metastasis to bone: causes, consequences and therapeutic opportunities.	Gregory R Mundy	Nat Rev Cancer	2002	12154351	No
1047	1857	1857.0	43.2	43.2	Defensins: antimicrobial peptides of innate immunity.	Tomas Ganz	Nat Rev Immunol	2003	12949495	No
1048	3713	1856.5	81.16	40.6	Raster3D: photorealistic molecular graphics.	E A Merritt, D J Bacon	Methods Enzymol	1997	18488322	Yes
1049	1856	1856.0	53.78	53.8	The blood-brain barrier in health and chronic neurodegenerative disorders.	Berislav V Zlokovic	Neuron	2008	18215617	No
1050	1855	1855.0	52.78	52.8	The episodic buffer: a new component of working memory?	Baddeley	Trends Cogn Sci	2000	11058819	Yes
1051	3705	1852.5	0.0	0.0	Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells.	J G Rheinwald, H Green	Cell	1975	1052771	Yes
1052	3701	1850.5	122.07	61.0	Oxygen toxicity, oxygen radicals, transition metals and disease.	B Halliwell, J M Gutteridge	Biochem J	1984	6326753	No
1053	1849	1849.0	39.18	39.2	The expanding role of mitochondria in apoptosis.	X Wang	Genes Dev	2001	11711427	No
1054	1848	1848.0	56.11	56.1	The nuclear factor NF-kappaB pathway in inflammation.	Toby Lawrence	Cold Spring Harb Perspect Biol	2009	20457564	No
1055	1844	1844.0	62.53	62.5	The use of a plus-maze to measure anxiety in the mouse.	R G Lister	Psychopharmacology (Berl)	1987	3110839	Yes
1056	3687	1843.5	0.0	0.0	Immunoassay of insulin with insulin-antibody precipitate.	C N Hales, P J Randle	Biochem J	1963	13952078	Yes
1057	5530	1843.3	0.0	0.0	A rapid method for the isolation of functional thymus-derived murine lymphocytes.	M H Julius, E Simpson, L A Herzenberg	Eur J Immunol	1973	4587740	Yes
1058	1841	1841.0	45.31	45.3	Thioredoxin.	A Holmgren	Annu Rev Biochem	1985	3896121	No
1059	3681	1840.5	76.8	38.4	Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals.	Rudolf Jaenisch, Adrian Bird	Nat Genet	2003	12610534	No
1060	3674	1837.0	107.37	53.7	Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration.	B J Marshall, J R Warren	Lancet	1984	6145023	Yes
1061	3674	1837.0	84.69	42.3	Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.	T Miyashita, J C Reed	Cell	1995	7834749	Yes
1062	1835	1835.0	51.4	51.4	Epidemiology of insomnia: what we know and what we still need to learn.	Maurice M Ohayon	Sleep Med Rev	2002	12531146	Yes
1063	3669	1834.5	76.37	38.2	The Wnt signaling pathway in development and disease.	Catriona Y Logan, Roel Nusse	Annu Rev Cell Dev Biol	2004	15473860	No
1064	1834	1834.0	33.7	33.7	The regulation of E2F by pRB-family proteins.	N Dyson	Genes Dev	1998	9694791	No
1065	1832	1832.0	43.26	43.3	A clearer vision for in vivo imaging.	R Weissleder	Nat Biotechnol	2001	11283581	No
1066	3657	1828.5	90.03	45.0	The future of genetic studies of complex human diseases.	N Risch, K Merikangas	Science	1996	8801636	Yes
1067	7311	1827.8	256.28	64.1	Reporting results of cancer treatment.	A B Miller, B Hoogstraten, M Staquet, A Winkler	Cancer	1981	7459811	Yes
1068	7307	1826.8	192.71	48.2	Matrix elasticity directs stem cell lineage specification.	Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E Discher	Cell	2006	16923388	Yes
1069	3650	1825.0	88.28	44.1	The acute respiratory distress syndrome.	L B Ware, M A Matthay	N Engl J Med	2000	10793167	No
1070	1824	1824.0	0.0	0.0	The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides.	G S Manning	Q Rev Biophys	1978	353876	No
1071	1824	1824.0	0.0	0.0	A simple fluorometric assay for lipoperoxide in blood plasma.	K Yagi	Biochem Med	1976	962904	Yes
1072	1821	1821.0	68.16	68.2	Physiological aspects of primary hypertension.	B Folkow	Physiol Rev	1982	6461865	No
1073	3641	1820.5	93.64	46.8	Cutaneous wound healing.	A J Singer, R A Clark	N Engl J Med	1999	10471461	No
1074	1820	1820.0	44.92	44.9	Animal mitochondrial genomes.	J L Boore	Nucleic Acids Res	1999	10101183	No
1075	7275	1818.8	0.0	0.0	Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.	D J Sahn, A DeMaria, J Kisslo, A Weyman	Circulation	1978	709763	Yes
1076	3637	1818.5	75.63	37.8	Smad-dependent and Smad-independent pathways in TGF-beta family signalling.	Rik Derynck, Ying E Zhang	Nature	2003	14534577	No
1077	3632	1816.0	87.65	43.8	Brown adipose tissue: function and physiological significance.	Barbara Cannon, Jan Nedergaard	Physiol Rev	2004	14715917	No
1078	3631	1815.5	72.21	36.1	Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.	M Karin, Y Ben-Neriah	Annu Rev Immunol	2000	10837071	No
1079	1815	1815.0	46.64	46.6	Determination and analysis of urea and guanidine hydrochloride denaturation curves.	C N Pace	Methods Enzymol	1986	3773761	Yes
1080	1815	1815.0	37.68	37.7	Signalling pathways of the TNF superfamily: a double-edged sword.	Bharat B Aggarwal	Nat Rev Immunol	2003	12949498	No
1081	1814	1814.0	49.07	49.1	Hepatitis B virus infection.	W M Lee	N Engl J Med	1997	9392700	No
1082	14509	1813.6	412.69	51.6	Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.	R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A Erlich	Science	1988	2448875	Yes
1083	1811	1811.0	0.0	0.0	A Method Of Measuring Eye Movement Using A Scleral Search Coil In A Magnetic Field.	D A Robinson	IEEE Trans Biomed Eng	1963	14121113	Yes
1084	3615	1807.5	151.45	75.7	Extracellular vesicles: exosomes, microvesicles, and friends.	Graça Raposo, Willem Stoorvogel	J Cell Biol	2013	23420871	No
1085	3614	1807.0	0.0	0.0	Polymyositis and dermatomyositis (first of two parts).	A Bohan, J B Peter	N Engl J Med	1975	1090839	No
1086	1807	1807.0	46.06	46.1	Cancer chemoprevention with dietary phytochemicals.	Young-Joon Surh	Nat Rev Cancer	2003	14570043	No
1087	1805	1805.0	53.82	53.8	The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation.	G P Chrousos	N Engl J Med	1995	7715646	No
1088	1803	1803.0	62.1	62.1	Keratoconus.	Y S Rabinowitz	Surv Ophthalmol	1998	9493273	No
1089	1800	1800.0	49.81	49.8	Mechanisms of hepatic fibrogenesis.	Scott L Friedman	Gastroenterology	2008	18471545	No
1090	1799	1799.0	0.0	0.0	A rating instrument for anxiety disorders.	W W Zung	Psychosomatics	1971	5172928	Yes
1091	1799	1799.0	36.99	37.0	Systems biology: a brief overview.	Hiroaki Kitano	Science	2002	11872829	No
1092	5391	1797.0	175.83	58.6	Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders.	C Lord, M Rutter, A Le Couteur	J Autism Dev Disord	1994	7814313	Yes
1093	1797	1797.0	38.98	39.0	Thrombin signalling and protease-activated receptors.	S R Coughlin	Nature	2000	11001069	No
1094	1797	1797.0	0.0	0.0	The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application.	S Hestrin	J Biol Chem	1949	18133390	Yes
1095	16168	1796.4	1042.45	115.8	Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.	Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray	Int J Cancer	2015	25220842	Yes
1096	1796	1796.0	46.77	46.8	Dopamine, learning and motivation.	Roy A Wise	Nat Rev Neurosci	2004	15152198	No
1097	1795	1795.0	40.61	40.6	Theta oscillations in the hippocampus.	György Buzsáki	Neuron	2002	11832222	No
1098	3590	1795.0	94.27	47.1	The endophenotype concept in psychiatry: etymology and strategic intentions.	Irving I Gottesman, Todd D Gould	Am J Psychiatry	2003	12668349	No
1099	5375	1791.7	136.55	45.5	Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.	Z N Oltvai, C L Milliman, S J Korsmeyer	Cell	1993	8358790	Yes
1100	3583	1791.5	166.88	83.4	The Health Belief Model: a decade later.	N K Janz, M H Becker	Health Educ Q	1984	6392204	No
1101	3583	1791.5	119.67	59.8	Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections.	Jeng-Da Chai, Martin Head-Gordon	Phys Chem Chem Phys	2008	18989472	Yes
1102	1791	1791.0	56.05	56.0	Hazards of heavy metal contamination.	Lars Järup	Br Med Bull	2003	14757716	No
1103	1790	1790.0	40.04	40.0	The immunopathogenesis of sepsis.	Jonathan Cohen	Nature	2002	12490963	No
1104	1789	1789.0	49.59	49.6	A computational procedure for determining energetically favorable binding sites on biologically important macromolecules.	P J Goodford	J Med Chem	1985	3892003	Yes
1105	1789	1789.0	0.0	0.0	A classification of hand preference by association analysis.	M Annett	Br J Psychol	1970	5457503	Yes
1106	1789	1789.0	59.34	59.3	Heavy metal intensification of DAB-based HRP reaction product.	J C Adams	J Histochem Cytochem	1981	7252134	Yes
1107	1789	1789.0	48.09	48.1	Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details.	R D Pascual-Marqui	Methods Find Exp Clin Pharmacol	2002	12575463	No
1108	1788	1788.0	0.0	0.0	The measurement of volume changes in human limbs.	R J Whitney	J Physiol	1953	13085295	Yes
1109	1787	1787.0	59.41	59.4	Social cognitive theory: an agentic perspective.	A Bandura	Annu Rev Psychol	2001	11148297	Yes
1110	3573	1786.5	162.94	81.5	The Brief Symptom Inventory: an introductory report.	L R Derogatis, N Melisaratos	Psychol Med	1983	6622612	Yes
1111	5359	1786.3	125.82	41.9	A new statistical method for haplotype reconstruction from population data.	M Stephens, N J Smith, P Donnelly	Am J Hum Genet	2001	11254454	Yes
1112	1785	1785.0	43.9	43.9	The mitochondrial permeability transition pore and its role in cell death.	M Crompton	Biochem J	1999	10393078	No
1113	1784	1784.0	40.95	41.0	Cellular mechanisms of insulin resistance.	G I Shulman	J Clin Invest	2000	10903330	No
1114	1783	1783.0	60.72	60.7	Physiological actions of taurine.	R J Huxtable	Physiol Rev	1992	1731369	No
1115	1782	1782.0	41.31	41.3	DNA topoisomerases.	J C Wang	Annu Rev Biochem	1996	8811192	No
1116	1780	1780.0	0.0	0.0	Estimability and estimation in case-referent studies.	O Miettinen	Am J Epidemiol	1976	1251836	Yes
1117	5338	1779.3	114.27	38.1	EMBOSS: the European Molecular Biology Open Software Suite.	P Rice, I Longden, A Bleasby	Trends Genet	2000	10827456	Yes
1118	1779	1779.0	0.0	0.0	High-speed scanning in human memory.	S Sternberg	Science	1966	5939936	Yes
1119	1779	1779.0	42.15	42.1	Global cancer statistics in the year 2000.	D M Parkin	Lancet Oncol	2001	11905707	No
1120	5335	1778.3	178.11	59.4	AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet.	P G Reeves, F H Nielsen, G C Fahey	J Nutr	1993	8229312	No
1121	7113	1778.2	0.0	0.0	Antibiotic susceptibility testing by a standardized single disk method.	A W Bauer, W M Kirby, J C Sherris, M Turck	Am J Clin Pathol	1966	5325707	Yes
1122	1778	1778.0	36.92	36.9	DNA topoisomerases: structure, function, and mechanism.	J J Champoux	Annu Rev Biochem	2001	11395412	No
1123	1778	1778.0	36.75	36.8	Antiviral actions of interferons.	C E Samuel	Clin Microbiol Rev	2001	11585785	No
1124	1777	1777.0	39.77	39.8	TRP channels as cellular sensors.	David E Clapham	Nature	2003	14654832	No
1125	3553	1776.5	119.62	59.8	Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease.	R A DeFronzo, E Ferrannini	Diabetes Care	1991	2044434	No
1126	3552	1776.0	93.11	46.6	Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.	Michael T Lin, M Flint Beal	Nature	2006	17051205	No
1127	3550	1775.0	0.0	0.0	Maturation of the head of bacteriophage T4. I. DNA packaging events.	U K Laemmli, M Favre	J Mol Biol	1973	4204102	Yes
1128	1775	1775.0	0.0	0.0	A theory of cerebellar cortex.	D Marr	J Physiol	1969	5784296	Yes
1129	1773	1773.0	87.91	87.9	Performance-oriented assessment of mobility problems in elderly patients.	M E Tinetti	J Am Geriatr Soc	1986	3944402	Yes
1130	15956	1772.9	358.31	39.8	Cytoscape: a software environment for integrated models of biomolecular interaction networks.	Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey Ideker	Genome Res	2003	14597658	Yes
1131	1772	1772.0	66.09	66.1	Why patients use alternative medicine: results of a national study.	J A Astin	JAMA	1998	9605899	Yes
1132	1772	1772.0	46.16	46.2	The hydrogen bond in the solid state.	Thomas Steiner	Angew Chem Int Ed Engl	2002	12491444	Yes
1133	3543	1771.5	136.77	68.4	The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories.	P F Lovibond, S H Lovibond	Behav Res Ther	1995	7726811	Yes
1134	7085	1771.2	240.13	60.0	Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.	A J Hughes, S E Daniel, L Kilford, A J Lees	J Neurol Neurosurg Psychiatry	1992	1564476	Yes
1135	3542	1771.0	0.0	0.0	Mathematical model for studying genetic variation in terms of restriction endonucleases.	M Nei, W H Li	Proc Natl Acad Sci U S A	1979	291943	Yes
1136	1771	1771.0	67.13	67.1	Recognition-by-components: a theory of human image understanding.	Irving Biederman	Psychol Rev	1987	3575582	Yes
1137	1771	1771.0	52.18	52.2	Accurate Coulomb-fitting basis sets for H to Rn.	Florian Weigend	Phys Chem Chem Phys	2006	16633586	Yes
1138	5312	1770.7	154.85	51.6	Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors.	F E Harrell, K L Lee, D B Mark	Stat Med	1996	8668867	No
1139	5308	1769.3	146.89	49.0	Canonical sampling through velocity rescaling.	Giovanni Bussi, Davide Donadio, Michele Parrinello	J Chem Phys	2007	17212484	Yes
1140	1769	1769.0	0.0	0.0	Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.	U Ungerstedt	Acta Physiol Scand Suppl	1971	4332693	Yes
1141	3537	1768.5	0.0	0.0	Multiple receptors for dopamine.	J W Kebabian, D B Calne	Nature	1979	215920	No
1142	1768	1768.0	0.0	0.0	The influence of some cations on an adenosine triphosphatase from peripheral nerves.	J C Skou	Biochim Biophys Acta	1957	13412736	Yes
1143	1768	1768.0	50.52	50.5	The physiology of glucagon-like peptide 1.	Jens Juul Holst	Physiol Rev	2007	17928588	No
1144	3535	1767.5	74.6	37.3	Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia.	C D Nobes, A Hall	Cell	1995	7536630	Yes
1145	3533	1766.5	124.29	62.1	Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine.	M H Zweig, G Campbell	Clin Chem	1993	8472349	No
1146	1766	1766.0	59.35	59.4	Sick individuals and sick populations.	G Rose	Int J Epidemiol	1985	3872850	Yes
1147	1765	1765.0	38.87	38.9	The complex language of chromatin regulation during transcription.	Shelley L Berger	Nature	2007	17522673	No
1148	5291	1763.7	173.99	58.0	The brain's default network: anatomy, function, and relevance to disease.	Randy L Buckner, Jessica R Andrews-Hanna, Daniel L Schacter	Ann N Y Acad Sci	2008	18400922	No
1149	1763	1763.0	36.75	36.8	Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls.	R J Kaufman	Genes Dev	1999	10346810	No
1150	7046	1761.5	175.87	44.0	Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels.	A Shevchenko, M Wilm, O Vorm, M Mann	Anal Chem	1996	8779443	Yes
1151	7039	1759.8	280.12	70.0	A simple technique for quantitation of low levels of DNA damage in individual cells.	N P Singh, M T McCoy, R R Tice, E L Schneider	Exp Cell Res	1988	3345800	Yes
1152	1758	1758.0	62.06	62.1	The free-energy principle: a unified brain theory?	Karl Friston	Nat Rev Neurosci	2010	20068583	No
1153	1757	1757.0	32.89	32.9	Mechanisms of alternative pre-messenger RNA splicing.	Douglas L Black	Annu Rev Biochem	2003	12626338	No
1154	3513	1756.5	121.89	60.9	Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.	G Di Chiara, A Imperato	Proc Natl Acad Sci U S A	1988	2899326	Yes
1155	1756	1756.0	51.58	51.6	Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.	A Dunaif	Endocr Rev	1997	9408743	No
1156	1756	1756.0	45.7	45.7	Negative refraction makes a perfect lens	Pendry	Phys Rev Lett	2000	11041972	Yes
1157	1756	1756.0	44.92	44.9	The global health burden of infection-associated cancers in the year 2002.	Donald Maxwell Parkin	Int J Cancer	2006	16404738	Yes
1158	1755	1755.0	48.02	48.0	Accurate description of van der Waals complexes by density functional theory including empirical corrections.	Stefan Grimme	J Comput Chem	2004	15224390	Yes
1159	1755	1755.0	45.43	45.4	DAMPs, PAMPs and alarmins: all we need to know about danger.	Marco E Bianchi	J Leukoc Biol	2007	17032697	No
1160	3509	1754.5	85.61	42.8	Protein folding in the cell.	M J Gething, J Sambrook	Nature	1992	1731198	No
1161	1754	1754.0	33.9	33.9	Automated electron microscope tomography using robust prediction of specimen movements.	David N Mastronarde	J Struct Biol	2005	16182563	Yes
1162	1753	1753.0	62.1	62.1	The role of hormone receptors and GTP-regulatory proteins in membrane transduction.	M Rodbell	Nature	1980	6101906	Yes
1163	1753	1753.0	44.72	44.7	The dawning era of polymer therapeutics.	Ruth Duncan	Nat Rev Drug Discov	2003	12750738	No
1164	1752	1752.0	47.78	47.8	G proteins and dual control of adenylate cyclase.	A G Gilman	Cell	1984	6321035	Yes
1165	1752	1752.0	37.0	37.0	An extensively modified version of MolScript that includes greatly enhanced coloring capabilities.	R M Esnouf	J Mol Graph Model	1997	9385560	Yes
1166	5255	1751.7	104.26	34.8	Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.	Jason D Fontenot, Marc A Gavin, Alexander Y Rudensky	Nat Immunol	2003	12612578	Yes
1167	1751	1751.0	45.55	45.5	Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials.	Fiona Turnbull	Lancet	2003	14615107	Yes
1168	3499	1749.5	93.13	46.6	Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.	K D McCarthy, J de Vellis	J Cell Biol	1980	6248568	Yes
1169	6997	1749.2	270.71	67.7	The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire.	T F Heatherton, L T Kozlowski, R C Frecker, K O Fagerström	Br J Addict	1991	1932883	Yes
1170	1746	1746.0	0.0	0.0	On respiratory impairment in cancer cells.	O Warburg	Science	1956	13351639	Yes
1171	1745	1745.0	39.74	39.7	A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics.	J SantaLucia	Proc Natl Acad Sci U S A	1998	9465037	Yes
1172	3483	1741.5	0.0	0.0	A complementation analysis of the restriction and modification of DNA in Escherichia coli.	H W Boyer, D Roulland-Dussoix	J Mol Biol	1969	4896022	Yes
1173	1741	1741.0	0.0	0.0	A personality scale of manifest anxiety.	J A Taylor	J Abnorm Psychol	1953	13052352	Yes
1174	1741	1741.0	58.38	58.4	TGFβ signalling in context.	Joan Massagué	Nat Rev Mol Cell Biol	2012	22992590	No
1175	1739	1739.0	51.2	51.2	Endoplasmic reticulum stress and the inflammatory basis of metabolic disease.	Gökhan S Hotamisligil	Cell	2010	20303879	No
1176	1739	1739.0	59.91	59.9	Guided Search 2.0 A revised model of visual search.	J M Wolfe	Psychon Bull Rev	1994	24203471	Yes
1177	1738	1738.0	58.76	58.8	Drugs of abuse: anatomy, pharmacology and function of reward pathways.	G F Koob	Trends Pharmacol Sci	1992	1604710	No
1178	1738	1738.0	58.19	58.2	Health consequences of intimate partner violence.	Jacquelyn C Campbell	Lancet	2002	11965295	No
1179	1735	1735.0	40.01	40.0	Steroid receptor regulated transcription of specific genes and gene networks.	K R Yamamoto	Annu Rev Genet	1985	3909942	No
1180	1735	1735.0	45.84	45.8	Interfaces and the driving force of hydrophobic assembly.	David Chandler	Nature	2005	16193038	No
1181	1732	1732.0	0.0	0.0	Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu.	M J Casadaban	J Mol Biol	1976	781293	Yes
1182	1732	1732.0	62.08	62.1	A cortical network for directed attention and unilateral neglect.	M M Mesulam	Ann Neurol	1981	7032417	No
1183	1731	1731.0	81.64	81.6	Determinants of low birth weight: methodological assessment and meta-analysis.	M S Kramer	Bull World Health Organ	1987	3322602	No
1184	1731	1731.0	48.76	48.8	New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures.	R Y Tsien	Biochemistry	1980	6770893	Yes
1185	1731	1731.0	42.37	42.4	Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome.	B L Wajchenberg	Endocr Rev	2000	11133069	No
1186	1729	1729.0	44.79	44.8	Drug-like properties and the causes of poor solubility and poor permeability.	C A Lipinski	J Pharmacol Toxicol Methods	2000	11274893	No
1187	5187	1729.0	130.77	43.6	APE: Analyses of Phylogenetics and Evolution in R language.	Emmanuel Paradis, Julien Claude, Korbinian Strimmer	Bioinformatics	2004	14734327	Yes
1188	1728	1728.0	44.77	44.8	The pathophysiology of tumor necrosis factors.	P Vassalli	Annu Rev Immunol	1992	1590993	No
1189	5184	1728.0	172.49	57.5	Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data.	L Excoffier, P E Smouse, J M Quattro	Genetics	1992	1644282	Yes
1190	3453	1726.5	66.44	33.2	Rho GTPases in cell biology.	Sandrine Etienne-Manneville, Alan Hall	Nature	2002	12478284	No
1191	1725	1725.0	42.66	42.7	Metabolomics--the link between genotypes and phenotypes.	Oliver Fiehn	Plant Mol Biol	2002	11860207	No
1192	1724	1724.0	46.19	46.2	Interleukin-6: an overview.	J Van Snick	Annu Rev Immunol	1990	2188664	No
1193	1724	1724.0	0.0	0.0	The etiology of chondromalacia patellae.	R E Outerbridge	J Bone Joint Surg Br	1961	14038135	Yes
1194	1723	1723.0	46.56	46.6	A theory of cortical responses.	Karl Friston	Philos Trans R Soc Lond B Biol Sci	2005	15937014	No
1195	5168	1722.7	113.43	37.8	Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons.	A Nicholls, K A Sharp, B Honig	Proteins	1991	1758883	Yes
1196	1722	1722.0	62.48	62.5	Cyclosporine.	B D Kahan	N Engl J Med	1989	2687689	No
1197	1722	1722.0	39.2	39.2	The synaptic vesicle cycle: a cascade of protein-protein interactions.	T C Südhof	Nature	1995	7791897	No
1198	1721	1721.0	54.91	54.9	An overview of brominated flame retardants in the environment.	Cynthia A de Wit	Chemosphere	2002	11999784	No
1199	3440	1720.0	93.33	46.7	Prediction of protein antigenic determinants from amino acid sequences.	T P Hopp, K R Woods	Proc Natl Acad Sci U S A	1981	6167991	Yes
1200	1720	1720.0	56.38	56.4	Calculation of substrate oxidation rates in vivo from gaseous exchange.	K N Frayn	J Appl Physiol Respir Environ Exerc Physiol	1983	6618956	Yes
1201	5157	1719.0	1725.64	575.2	Cancer statistics, 2020.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2020	31912902	Yes
1202	3435	1717.5	88.63	44.3	The biology of vascular endothelial growth factor.	N Ferrara, T Davis-Smyth	Endocr Rev	1997	9034784	No
1203	1717	1717.0	32.78	32.8	CD4+ CD25+ suppressor T cells: more questions than answers.	Ethan M Shevach	Nat Rev Immunol	2002	12093005	No
1204	1716	1716.0	0.0	0.0	Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals.	J N Dumont	J Morphol	1972	4109871	Yes
1205	1716	1716.0	0.0	0.0	ATPase activity of myosin correlated with speed of muscle shortening.	M Bárány	J Gen Physiol	1967	4227924	Yes
1206	1715	1715.0	72.59	72.6	The Resonating Valence Bond State in La2CuO4 and Superconductivity.	P W Anderson	Science	1987	17818979	Yes
1207	1714	1714.0	67.61	67.6	Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review.	H U Wittchen	J Psychiatr Res	1994	8064641	No
1208	3425	1712.5	76.24	38.1	Cell death: critical control points.	Nika N Danial, Stanley J Korsmeyer	Cell	2004	14744432	No
1209	1712	1712.0	0.0	0.0	The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers.	R Ross	J Cell Biol	1971	4327464	Yes
1210	5135	1711.7	232.08	77.4	Some statistical methods useful in circulation research.	S Wallenstein, C L Zucker, J L Fleiss	Circ Res	1980	7379260	Yes
1211	1710	1710.0	0.0	0.0	Dynamic properties of mammalian skeletal muscles.	R I Close	Physiol Rev	1972	4256989	No
1212	1710	1710.0	38.09	38.1	Developmental regulation of the growth plate.	Henry M Kronenberg	Nature	2003	12748651	No
1213	1709	1709.0	0.0	0.0	The statistical analysis of enzyme kinetic data.	W W Cleland	Adv Enzymol Relat Areas Mol Biol	1967	4881884	No
1214	5127	1709.0	135.2	45.1	Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.	G S Hotamisligil, N S Shargill, B M Spiegelman	Science	1993	7678183	Yes
1215	1709	1709.0	40.47	40.5	Neutrophils and immunity: challenges and opportunities.	Carl Nathan	Nat Rev Immunol	2006	16498448	No
1216	1709	1709.0	43.39	43.4	Targeting PI3K signalling in cancer: opportunities, challenges and limitations.	Jeffrey A Engelman	Nat Rev Cancer	2009	19629070	No
1217	1708	1708.0	0.0	0.0	Comparison of the predicted and observed secondary structure of T4 phage lysozyme.	B W Matthews	Biochim Biophys Acta	1975	1180967	Yes
1218	3415	1707.5	0.0	0.0	The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent.	A E Bolton, W M Hunter	Biochem J	1973	4733239	Yes
1219	1707	1707.0	48.4	48.4	The extracellular matrix: not just pretty fibrils.	Richard O Hynes	Science	2009	19965464	No
1220	6827	1706.8	133.33	33.3	Transformation of intact yeast cells treated with alkali cations.	H Ito, Y Fukuda, K Murata, A Kimura	J Bacteriol	1983	6336730	Yes
1221	1706	1706.0	93.04	93.0	The assessment of clinical skills/competence/performance.	G E Miller	Acad Med	1990	2400509	Yes
1222	1706	1706.0	0.0	0.0	Positional information and the spatial pattern of cellular differentiation.	L Wolpert	J Theor Biol	1969	4390734	Yes
1223	5108	1702.7	169.03	56.3	Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire.	R L Spitzer, K Kroenke, J B Williams	JAMA	1999	10568646	Yes
1224	1702	1702.0	33.5	33.5	Approaching the asymptote? Evolution and revolution in immunology.	C A Janeway	Cold Spring Harb Symp Quant Biol	1989	2700931	No
1225	1702	1702.0	36.46	36.5	Structure and regulation of voltage-gated Ca2+ channels.	W A Catterall	Annu Rev Cell Dev Biol	2000	11031246	No
1226	18712	1701.1	414.94	37.7	Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.	Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P Mesirov	Proc Natl Acad Sci U S A	2005	16199517	Yes
1227	1700	1700.0	34.75	34.8	Notch signalling: a simple pathway becomes complex.	Sarah J Bray	Nat Rev Mol Cell Biol	2006	16921404	No
1228	11894	1699.1	276.16	39.5	Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes.	Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman	Genome Biol	2002	12184808	Yes
1229	3397	1698.5	86.63	43.3	Measuring the thickness of the human cerebral cortex from magnetic resonance images.	B Fischl, A M Dale	Proc Natl Acad Sci U S A	2000	10984517	Yes
1230	6794	1698.5	147.05	36.8	WebLogo: a sequence logo generator.	Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E Brenner	Genome Res	2004	15173120	Yes
1231	3396	1698.0	90.43	45.2	Cloned glutamate receptors.	M Hollmann, S Heinemann	Annu Rev Neurosci	1994	8210177	No
1232	1697	1697.0	0.0	0.0	Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.	E M Witkin	Bacteriol Rev	1976	795416	No
1233	1696	1696.0	0.0	0.0	Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry.	M Wong-Riley	Brain Res	1979	223730	Yes
1234	1696	1696.0	100.25	100.2	Determination and quantification of content validity.	M R Lynn	Nurs Res	1986	3640358	Yes
1235	1696	1696.0	0.0	0.0	Protein denaturation.	C Tanford	Adv Protein Chem	1968	4882248	No
1236	1696	1696.0	0.0	0.0	A graphic method for the determination and presentation of binding parameters in a complex system.	H E Rosenthal	Anal Biochem	1967	6048188	Yes
1237	1695	1695.0	54.52	54.5	Glutamate: a neurotransmitter in mammalian brain.	F Fonnum	J Neurochem	1984	6139418	No
1238	3388	1694.0	93.45	46.7	Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction.	K B Mullis, F A Faloona	Methods Enzymol	1987	3431465	Yes
1239	1693	1693.0	0.0	0.0	Method for the determination of hexosamines in tissues.	N F Boas	J Biol Chem	1953	13117829	Yes
1240	1693	1693.0	46.21	46.2	Follicular helper CD4 T cells (TFH).	Shane Crotty	Annu Rev Immunol	2011	21314428	No
1241	1692	1692.0	57.06	57.1	Epidemiological features of chronic low-back pain.	G B Andersson	Lancet	1999	10470716	No
1242	1691	1691.0	43.14	43.1	Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures.	D Lavanchy	J Viral Hepat	2004	14996343	No
1243	3381	1690.5	157.77	78.9	Multiwfn: a multifunctional wavefunction analyzer.	Tian Lu, Feiwu Chen	J Comput Chem	2012	22162017	Yes
1244	3379	1689.5	86.21	43.1	Matrix metalloproteinases.	H Nagase, J F Woessner	J Biol Chem	1999	10419448	No
1245	1689	1689.0	45.79	45.8	Integrins.	E Ruoslahti	J Clin Invest	1991	1985087	No
1246	1689	1689.0	44.49	44.5	Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.	G C Walker	Microbiol Rev	1984	6371470	No
1247	3376	1688.0	0.0	0.0	A "Direct-Coloring" Thiocholine Method For Cholinesterases.	M J Karnovsky, L Roots	J Histochem Cytochem	1964	14187330	Yes
1248	1687	1687.0	0.0	0.0	Determination of free amino groups in proteins by trinitrobenzenesulfonic acid.	A F Habeeb	Anal Biochem	1966	4161471	Yes
1249	3373	1686.5	72.07	36.0	Identification of common molecular subsequences.	T F Smith, M S Waterman	J Mol Biol	1981	7265238	Yes
1250	1686	1686.0	31.71	31.7	How eukaryotic transcriptional activators work.	M Ptashne	Nature	1988	3050531	No
1251	1686	1686.0	57.84	57.8	Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes.	C E Mogensen	N Engl J Med	1984	6690964	Yes
1252	1685	1685.0	56.57	56.6	Pineal melatonin: cell biology of its synthesis and of its physiological interactions.	R J Reiter	Endocr Rev	1991	1649044	No
1253	1685	1685.0	63.38	63.4	Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury.	D R Janero	Free Radic Biol Med	1990	2079232	No
1254	1685	1685.0	57.98	58.0	Large-scale neurocognitive networks and distributed processing for attention, language, and memory.	M M Mesulam	Ann Neurol	1990	2260847	No
1255	5053	1684.3	204.15	68.0	featureCounts: an efficient general purpose program for assigning sequence reads to genomic features.	Yang Liao, Gordon K Smyth, Wei Shi	Bioinformatics	2014	24227677	Yes
1256	1684	1684.0	54.01	54.0	Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.	M Zasloff	Proc Natl Acad Sci U S A	1987	3299384	Yes
1257	1684	1684.0	53.63	53.6	Social determinants of health inequalities.	Michael Marmot	Lancet	2005	15781105	Yes
1258	1682	1682.0	40.65	40.6	The molecular genetics of cancer.	J M Bishop	Science	1987	3541204	No
1259	1682	1682.0	35.59	35.6	MicroRNA biogenesis: coordinated cropping and dicing.	V Narry Kim	Nat Rev Mol Cell Biol	2005	15852042	No
1260	1682	1682.0	41.88	41.9	Integrating cell-signalling pathways with NF-kappaB and IKK function.	Neil D Perkins	Nat Rev Mol Cell Biol	2007	17183360	No
1261	5044	1681.3	251.2	83.7	HISAT: a fast spliced aligner with low memory requirements.	Daehwan Kim, Ben Langmead, Steven L Salzberg	Nat Methods	2015	25751142	Yes
1262	1681	1681.0	0.0	0.0	Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.	A Krishan	J Cell Biol	1975	49354	Yes
1263	1681	1681.0	0.0	0.0	An improved procedure for serum creatine phosphokinase determination.	S B Rosalki	J Lab Clin Med	1967	4381359	Yes
1264	1681	1681.0	36.41	36.4	Molecular regulation of vessel maturation.	Rakesh K Jain	Nat Med	2003	12778167	No
1265	5039	1679.7	99.92	33.3	Surfing the p53 network.	B Vogelstein, D Lane, A J Levine	Nature	2000	11099028	No
1266	1679	1679.0	0.0	0.0	Why genes in pieces?	W Gilbert	Nature	1978	622185	Yes
1267	1679	1679.0	0.0	0.0	The theory and applications of the exchange of inert gas at the lungs and tissues.	S S Kety	Pharmacol Rev	1951	14833874	Yes
1268	1678	1678.0	36.33	36.3	Mechanisms of cancer drug resistance.	Michael M Gottesman	Annu Rev Med	2002	11818492	No
1269	1678	1678.0	0.0	0.0	Plastic Embedding Mixtures For Use In Electron Microscopy.	H H Mollenhauer	Stain Technol	1964	14127791	Yes
1270	16771	1677.1	532.9	53.3	Measurement of protein using bicinchoninic acid.	P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C Klenk	Anal Biochem	1985	3843705	Yes
1271	1677	1677.0	0.0	0.0	Dendritic organization in the neurons of the visual and motor cortices of the cat.	D A Sholl	J Anat	1953	13117757	Yes
1272	3352	1676.0	0.0	0.0	The Carbon Monoxide-Binding Pigment Of Liver Microsomes. Ii. Solubilization, Purification, And Properties.	T Omura, R Sato	J Biol Chem	1964	14209972	Yes
1273	1675	1675.0	0.0	0.0	Transplacental carcinogenesis by stilbestrol.	J Folkman	N Engl J Med	1971	5556579	Yes
1274	3347	1673.5	94.25	47.1	Biochemistry of multidrug resistance mediated by the multidrug transporter.	M M Gottesman, I Pastan	Annu Rev Biochem	1993	8102521	No
1275	3346	1673.0	0.0	0.0	Receptive fields and functional architecture of monkey striate cortex.	D H Hubel, T N Wiesel	J Physiol	1968	4966457	Yes
1276	1673	1673.0	44.76	44.8	Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver.	Scott L Friedman	Physiol Rev	2008	18195085	No
1277	1672	1672.0	37.89	37.9	The distribution of secondary growths in cancer of the breast. 1889.	S Paget	Cancer Metastasis Rev	1989	2673568	No
1278	1672	1672.0	40.7	40.7	Evolutionary relationship of DNA sequences in finite populations.	F Tajima	Genetics	1983	6628982	Yes
1279	1672	1672.0	40.75	40.8	Type III protein secretion systems in bacterial pathogens of animals and plants.	C J Hueck	Microbiol Mol Biol Rev	1998	9618447	No
1280	1671	1671.0	0.0	0.0	Drugs which inhibit prostaglandin biosynthesis.	R J Flower	Pharmacol Rev	1974	4208101	Yes
1281	1671	1671.0	0.0	0.0	Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.	J A Miller	Cancer Res	1970	4915745	No
1282	1670	1670.0	0.0	0.0	The general adaptation syndrome and the diseases of adaptation.	H Selye	J Clin Endocrinol Metab	1946	21025115	Yes
1283	6676	1669.0	0.0	0.0	Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.	E A Jaffe, R L Nachman, C G Becker, C R Minick	J Clin Invest	1973	4355998	Yes
1284	1669	1669.0	0.0	0.0	Evolutionary rate at the molecular level.	M Kimura	Nature	1968	5637732	Yes
1285	11681	1668.7	294.62	42.1	Induction of pluripotent stem cells from adult human fibroblasts by defined factors.	Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka	Cell	2007	18035408	Yes
1286	1668	1668.0	60.94	60.9	Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts).	G G Glenner	N Engl J Med	1980	6154243	No
1287	4995	1665.0	115.67	38.6	Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR.	Michael W Pfaffl, Graham W Horgan, Leo Dempfle	Nucleic Acids Res	2002	11972351	Yes
1288	8320	1664.0	232.94	46.6	Global prevalence of diabetes: estimates for the year 2000 and projections for 2030.	Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary King	Diabetes Care	2004	15111519	Yes
1289	1663	1663.0	58.05	58.0	Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.	A H Conney	Cancer Res	1982	6814745	No
1290	1663	1663.0	0.0	0.0	Chromatographic Separation Of Human Brain Gangliosides.	L Svennerholm	J Neurochem	1963	14066623	Yes
1291	1662	1662.0	70.1	70.1	Perception of risk.	P Slovic	Science	1987	3563507	Yes
1292	3322	1661.0	148.06	74.0	The MOS social support survey.	C D Sherbourne, A L Stewart	Soc Sci Med	1991	2035047	Yes
1293	3321	1660.5	0.0	0.0	Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.	M Grunstein, D S Hogness	Proc Natl Acad Sci U S A	1975	1105573	Yes
1294	1659	1659.0	0.0	0.0	Areas, volumes, packing and protein structure.	F M Richards	Annu Rev Biophys Bioeng	1977	326146	No
1295	1659	1659.0	56.22	56.2	The crisis in antibiotic resistance.	H C Neu	Science	1992	1509257	No
1296	3317	1658.5	0.0	0.0	Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature.	J Marmur, P Doty	J Mol Biol	1962	14470099	Yes
1297	1658	1658.0	67.78	67.8	Predicting basal metabolic rate, new standards and review of previous work.	W N Schofield	Hum Nutr Clin Nutr	1985	4044297	Yes
1298	1658	1658.0	58.09	58.1	Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?	B Halliwell	Lancet	1994	7915779	No
1299	1657	1657.0	39.24	39.2	Solvent-accessible surfaces of proteins and nucleic acids.	M L Connolly	Science	1983	6879170	Yes
1300	1657	1657.0	0.0	0.0	Transformation Of Biochemically Deficient Strains Of Bacillus Subtilis By Deoxyribonucleate.	J Spizizen	Proc Natl Acad Sci U S A	1958	16590310	Yes
1301	1655	1655.0	0.0	0.0	Mode of cell migration to the superficial layers of fetal monkey neocortex.	P Rakic	J Comp Neurol	1972	4624784	Yes
1302	3309	1654.5	94.69	47.3	Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium.	Kresse, Hafner	Phys Rev B Condens Matter	1994	10010505	Yes
1303	1654	1654.0	34.44	34.4	Structural features in eukaryotic mRNAs that modulate the initiation of translation.	M Kozak	J Biol Chem	1991	1939050	No
1304	1654	1654.0	38.62	38.6	The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.	D M Kingsley	Genes Dev	1994	8299934	No
1305	1653	1653.0	56.08	56.1	Serum albumin.	T Peters	Adv Protein Chem	1985	3904348	No
1306	3306	1653.0	72.18	36.1	Integrin signaling.	F G Giancotti, E Ruoslahti	Science	1999	10446041	No
1307	1651	1651.0	0.0	0.0	Carbonic anhydrase: chemistry, physiology, and inhibition.	T H Maren	Physiol Rev	1967	4964060	No
1308	1651	1651.0	47.75	47.8	Biofilms: microbial life on surfaces.	Rodney M Donlan	Emerg Infect Dis	2002	12194761	No
1309	6602	1650.5	236.25	59.1	A brief measure for assessing generalized anxiety disorder: the GAD-7.	Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd Löwe	Arch Intern Med	2006	16717171	Yes
1310	1648	1648.0	48.85	48.9	Flavonoids as antioxidants.	P G Pietta	J Nat Prod	2000	10924197	No
1311	1648	1648.0	39.55	39.5	Fabrication of novel biomaterials through molecular self-assembly.	Shuguang Zhang	Nat Biotechnol	2003	14520402	No
1312	1648	1648.0	35.25	35.2	DNA methylation and human disease.	Keith D Robertson	Nat Rev Genet	2005	16136652	No
1313	3294	1647.0	85.62	42.8	Receptors for purines and pyrimidines.	V Ralevic, G Burnstock	Pharmacol Rev	1998	9755289	No
1314	1647	1647.0	36.93	36.9	Exploring complex networks.	S H Strogatz	Nature	2001	11258382	No
1315	1644	1644.0	0.0	0.0	Pedigrees of some mutant strains of Escherichia coli K-12.	B J Bachmann	Bacteriol Rev	1972	4568763	No
1316	1644	1644.0	0.0	0.0	A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma.	D Mattingly	J Clin Pathol	1962	14471419	Yes
1317	6575	1643.8	153.01	38.3	Use of T7 RNA polymerase to direct expression of cloned genes.	F W Studier, A H Rosenberg, J J Dunn, J W Dubendorff	Methods Enzymol	1990	2199796	Yes
1318	1641	1641.0	37.34	37.3	Effects of cytochalasin and phalloidin on actin.	J A Cooper	J Cell Biol	1987	3312229	No
1319	1641	1641.0	44.43	44.4	What is cognitive reserve? Theory and research application of the reserve concept.	Yaakov Stern	J Int Neuropsychol Soc	2002	11939702	No
1320	3281	1640.5	109.1	54.5	Role of free radicals and catalytic metal ions in human disease: an overview.	B Halliwell, J M Gutteridge	Methods Enzymol	1990	2172697	No
1321	1640	1640.0	34.18	34.2	Cancer and the chemokine network.	Fran Balkwill	Nat Rev Cancer	2004	15229479	No
1322	3280	1640.0	130.84	65.4	The biofilm matrix.	Hans-Curt Flemming, Jost Wingender	Nat Rev Microbiol	2010	20676145	No
1323	3274	1637.0	0.0	0.0	Method for the isolation of intact islets of Langerhans from the rat pancreas.	P E Lacy, M Kostianovsky	Diabetes	1967	5333500	Yes
1324	3274	1637.0	143.81	71.9	A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity.	J G Snodgrass, M Vanderwart	J Exp Psychol Hum Learn	1980	7373248	Yes
1325	1637	1637.0	51.97	52.0	The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions.	B L Fredrickson	Am Psychol	2001	11315248	Yes
1326	1636	1636.0	45.52	45.5	Turnover of inositol phospholipids and signal transduction.	Y Nishizuka	Science	1984	6147898	No
1327	3268	1634.0	79.18	39.6	The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.	P Angel, M Karin	Biochim Biophys Acta	1991	1751545	No
1328	1634	1634.0	44.26	44.3	Dengue and dengue hemorrhagic fever.	D J Gubler	Clin Microbiol Rev	1998	9665979	No
1329	1634	1634.0	69.11	69.1	Doxil®--the first FDA-approved nano-drug: lessons learned.	Yechezkel Barenholz	J Control Release	2012	22484195	No
1330	1633	1633.0	75.97	76.0	Role of nrf2 in oxidative stress and toxicity.	Qiang Ma	Annu Rev Pharmacol Toxicol	2013	23294312	No
1331	11423	1631.9	422.11	60.3	Assessing the quality of reports of randomized clinical trials: is blinding necessary?	A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuay	Control Clin Trials	1996	8721797	Yes
1332	3263	1631.5	75.82	37.9	Amino acid substitution matrices from protein blocks.	S Henikoff, J G Henikoff	Proc Natl Acad Sci U S A	1992	1438297	Yes
1333	1631	1631.0	51.3	51.3	Inhibited spontaneous emission in solid-state physics and electronics.	Yablonovitch	Phys Rev Lett	1987	10034639	Yes
1334	1631	1631.0	34.91	34.9	The effect of infections on susceptibility to autoimmune and allergic diseases.	Jean-Francois Bach	N Engl J Med	2002	12239261	No
1335	1630	1630.0	52.45	52.5	Metallothionein.	D H Hamer	Annu Rev Biochem	1986	3527054	No
1336	1630	1630.0	45.62	45.6	Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution.	H LeVine	Protein Sci	1993	8453378	Yes
1337	1630	1630.0	46.59	46.6	Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic.	Robert E Marx	J Oral Maxillofac Surg	2003	12966493	Yes
1338	3253	1626.5	80.96	40.5	Liver fibrosis.	Ramón Bataller, David A Brenner	J Clin Invest	2005	15690074	No
1339	1626	1626.0	38.74	38.7	NADPH oxidase: an update.	B M Babior	Blood	1999	10029572	No
1340	1626	1626.0	49.59	49.6	Intestinal mucosal barrier function in health and disease.	Jerrold R Turner	Nat Rev Immunol	2009	19855405	No
1341	3251	1625.5	86.17	43.1	Quantum dot bioconjugates for ultrasensitive nonisotopic detection.	W C Chan, S Nie	Science	1998	9748158	Yes
1342	1625	1625.0	48.66	48.7	Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996.	E M Wassermann	Electroencephalogr Clin Neurophysiol	1998	9474057	No
1343	3250	1625.0	105.53	52.8	Efficient pseudopotentials for plane-wave calculations.	Troullier, Martins	Phys Rev B Condens Matter	1991	9997467	Yes
1344	3250	1625.0	91.16	45.6	Protein structure prediction on the Web: a case study using the Phyre server.	Lawrence A Kelley, Michael J E Sternberg	Nat Protoc	2009	19247286	Yes
1345	16237	1623.7	522.42	52.2	The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.	F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S Luthra	Arthritis Rheum	1988	3358796	Yes
1346	3245	1622.5	74.03	37.0	Monocyte and macrophage heterogeneity.	Siamon Gordon, Philip R Taylor	Nat Rev Immunol	2005	16322748	No
1347	1622	1622.0	0.0	0.0	The micronucleus test.	W Schmid	Mutat Res	1975	48190	Yes
1348	1622	1622.0	36.32	36.3	Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury.	S L Friedman	J Biol Chem	2000	10644669	No
1349	1622	1622.0	60.56	60.6	Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium.	Sergio Pecorelli	Int J Gynaecol Obstet	2009	19367689	No
1350	1621	1621.0	58.61	58.6	Cell damage in the brain: a speculative synthesis.	B K Siesjö	J Cereb Blood Flow Metab	1981	6276420	No
1351	1621	1621.0	0.0	0.0	Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study.	E G Gray	J Anat	1959	13829103	Yes
1352	3241	1620.5	71.55	35.8	Protein structure comparison by alignment of distance matrices.	L Holm, C Sander	J Mol Biol	1993	8377180	Yes
1353	4860	1620.0	156.38	52.1	Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.	H Esterbauer, R J Schaur, H Zollner	Free Radic Biol Med	1991	1937131	No
1354	6477	1619.2	133.58	33.4	Stem cells, cancer, and cancer stem cells.	T Reya, S J Morrison, M F Clarke, I L Weissman	Nature	2001	11689955	No
1355	1619	1619.0	0.0	0.0	RNA-dependent DNA polymerase in virions of RNA tumour viruses.	D Baltimore	Nature	1970	4316300	Yes
1356	1619	1619.0	40.11	40.1	Inflammatory bowel disease: etiology and pathogenesis.	C Fiocchi	Gastroenterology	1998	9649475	No
1357	1619	1619.0	31.73	31.7	Cellular roles of DNA topoisomerases: a molecular perspective.	James C Wang	Nat Rev Mol Cell Biol	2002	12042765	No
1358	3236	1618.0	87.91	44.0	Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering	Nie, Emory	Science	1997	9027306	Yes
1359	1616	1616.0	49.07	49.1	Extracellular ATP: effects, sources and fate.	J L Gordon	Biochem J	1986	3006665	No
1360	1616	1616.0	32.06	32.1	Hox genes in vertebrate development.	R Krumlauf	Cell	1994	7913880	No
1361	1616	1616.0	32.38	32.4	Cell cycle checkpoints: preventing an identity crisis.	S J Elledge	Science	1996	8939848	No
1362	3228	1614.0	101.62	50.8	Nonparametric statistical testing of EEG- and MEG-data.	Eric Maris, Robert Oostenveld	J Neurosci Methods	2007	17517438	Yes
1363	3227	1613.5	100.54	50.3	Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability.	F Denizot, R Lang	J Immunol Methods	1986	3486233	Yes
1364	3227	1613.5	110.38	55.2	Wnt/β-catenin signaling and disease.	Hans Clevers, Roel Nusse	Cell	2012	22682243	No
1365	6453	1613.2	161.48	40.4	Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.	C A Lipinski, F Lombardo, B W Dominy, P J Feeney	Adv Drug Deliv Rev	2001	11259830	No
1366	1613	1613.0	82.54	82.5	Microplastics in the marine environment.	Anthony L Andrady	Mar Pollut Bull	2011	21742351	No
1367	1612	1612.0	51.46	51.5	The atom economy--a search for synthetic efficiency.	B M Trost	Science	1991	1962206	Yes
1368	1612	1612.0	70.62	70.6	Neurogenetic adaptive mechanisms in alcoholism.	C R Cloninger	Science	1987	2882604	Yes
1369	1612	1612.0	41.96	42.0	Neurotrophins and neuronal plasticity.	H Thoenen	Science	1995	7570017	No
1370	1611	1611.0	37.03	37.0	Cellular oncogenes and retroviruses.	J M Bishop	Annu Rev Biochem	1983	6351725	No
1371	1611	1611.0	44.87	44.9	Oxidative stress hypothesis in Alzheimer's disease.	W R Markesbery	Free Radic Biol Med	1997	9165306	No
1372	1610	1610.0	41.12	41.1	Clinical application of C-reactive protein for cardiovascular disease detection and prevention.	Paul M Ridker	Circulation	2003	12551853	No
1373	1610	1610.0	45.6	45.6	The comet assay for DNA damage and repair: principles, applications, and limitations.	Andrew R Collins	Mol Biotechnol	2004	15004294	No
1374	3218	1609.0	0.0	0.0	New method for quantitative determination of uronic acids.	N Blumenkrantz, G Asboe-Hansen	Anal Biochem	1973	4269305	Yes
1375	6430	1607.5	176.96	44.2	Epithelial-mesenchymal transitions in development and disease.	Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela Nieto	Cell	2009	19945376	No
1376	1607	1607.0	50.82	50.8	Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage.	D W Choi	Trends Neurosci	1988	2469166	No
1377	3214	1607.0	79.52	39.8	PRODRG: a tool for high-throughput crystallography of protein-ligand complexes.	Alexander W Schüttelkopf, Daan M F van Aalten	Acta Crystallogr D Biol Crystallogr	2004	15272157	Yes
1378	6427	1606.8	269.79	67.4	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	J Clin Epidemiol	2009	19631508	No
1379	3212	1606.0	0.0	0.0	A fluorometric method for determination of oxidized and reduced glutathione in tissues.	P J Hissin, R Hilf	Anal Biochem	1976	962076	Yes
1380	1606	1606.0	67.36	67.4	Negative symptoms in schizophrenia. Definition and reliability.	N C Andreasen	Arch Gen Psychiatry	1982	7165477	Yes
1381	1606	1606.0	44.79	44.8	Chlorpromazine equivalent doses for the newer atypical antipsychotics.	Scott W Woods	J Clin Psychiatry	2003	12823080	No
1382	3210	1605.0	95.93	48.0	The inflammasomes.	Kate Schroder, Jurg Tschopp	Cell	2010	20303873	No
1383	1604	1604.0	46.26	46.3	Cell biology and molecular basis of denitrification.	W G Zumft	Microbiol Mol Biol Rev	1997	9409151	No
1384	1604	1604.0	41.02	41.0	Episodic memory: from mind to brain.	Endel Tulving	Annu Rev Psychol	2002	11752477	Yes
1385	1604	1604.0	52.11	52.1	PsychoPy--Psychophysics software in Python.	Jonathan W Peirce	J Neurosci Methods	2007	17254636	Yes
1386	1604	1604.0	54.98	55.0	Global epidemiology of oral and oropharyngeal cancer.	Saman Warnakulasuriya	Oral Oncol	2009	18804401	No
1387	9623	1603.8	277.46	46.2	Positional cloning of the mouse obese gene and its human homologue.	Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M Friedman	Nature	1994	7984236	Yes
1388	1603	1603.0	0.0	0.0	Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion.	O Ouchterlony	Acta Pathol Microbiol Scand	1953	13079779	Yes
1389	3204	1602.0	126.98	63.5	Assays of glutathione peroxidase.	L Flohé, W A Günzler	Methods Enzymol	1984	6727659	Yes
1390	3204	1602.0	85.39	42.7	Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.	Christian Haass, Dennis J Selkoe	Nat Rev Mol Cell Biol	2007	17245412	No
1391	1601	1601.0	47.19	47.2	Metalloproteinases and their inhibitors in matrix remodeling.	L M Matrisian	Trends Genet	1990	2132731	No
1392	1601	1601.0	29.93	29.9	Maximum-likelihood density modification.	T C Terwilliger	Acta Crystallogr D Biol Crystallogr	2000	10944333	Yes
1393	1600	1600.0	44.89	44.9	An index to quantify an individual's scientific research output.	J E Hirsch	Proc Natl Acad Sci U S A	2005	16275915	Yes
1394	3198	1599.0	77.03	38.5	Rapid and sensitive protein similarity searches.	D J Lipman, W R Pearson	Science	1985	2983426	Yes
1395	1599	1599.0	48.84	48.8	MYC on the path to cancer.	Chi V Dang	Cell	2012	22464321	No
1396	1598	1598.0	50.45	50.5	A measure of population subdivision based on microsatellite allele frequencies.	M Slatkin	Genetics	1995	7705646	Yes
1397	1597	1597.0	35.24	35.2	Bone morphogenetic proteins: multifunctional regulators of vertebrate development.	B L Hogan	Genes Dev	1996	8682290	No
1398	1596	1596.0	36.94	36.9	VLA proteins in the integrin family: structures, functions, and their role on leukocytes.	M E Hemler	Annu Rev Immunol	1990	2188667	No
1399	1596	1596.0	30.33	30.3	Cyclin-dependent kinases: engines, clocks, and microprocessors.	D O Morgan	Annu Rev Cell Dev Biol	1997	9442875	No
1400	3192	1596.0	75.5	37.8	Parkinson's disease: mechanisms and models.	William Dauer, Serge Przedborski	Neuron	2003	12971891	No
1401	3192	1596.0	89.38	44.7	Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes.	Steven E Nissen, Kathy Wolski	N Engl J Med	2007	17517853	Yes
1402	3190	1595.0	63.88	31.9	Automated MAD and MIR structure solution.	T C Terwilliger, J Berendzen	Acta Crystallogr D Biol Crystallogr	1999	10089316	Yes
1403	1594	1594.0	0.0	0.0	Chromatin structure: a repeating unit of histones and DNA.	R D Kornberg	Science	1974	4825889	Yes
1404	3187	1593.5	63.3	31.6	Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene.	M E Greenberg, E B Ziff	Nature	1984	6090941	Yes
1405	7959	1591.8	210.51	42.1	Mapping and quantifying mammalian transcriptomes by RNA-Seq.	Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara Wold	Nat Methods	2008	18516045	Yes
1406	4770	1590.0	163.39	54.5	FastTree 2--approximately maximum-likelihood trees for large alignments.	Morgan N Price, Paramvir S Dehal, Adam P Arkin	PLoS One	2010	20224823	Yes
1407	1588	1588.0	31.74	31.7	An analysis of vertebrate mRNA sequences: intimations of translational control.	M Kozak	J Cell Biol	1991	1955461	No
1408	6347	1586.8	262.14	65.5	Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses.	Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg Lang	Behav Res Methods	2009	19897823	Yes
1409	3172	1586.0	0.0	0.0	Variations in the pattern of pubertal changes in boys.	W A Marshall, J M Tanner	Arch Dis Child	1970	5440182	Yes
1410	3170	1585.0	0.0	0.0	Determination of malonaldehyde precursor in tissues by thiobarbituric acid test.	M Mihara, M Uchiyama	Anal Biochem	1978	655387	Yes
1411	1584	1584.0	57.82	57.8	Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.	P Holzer	Pharmacol Rev	1991	1852779	No
1412	1584	1584.0	0.0	0.0	The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept.	A G Pearse	J Histochem Cytochem	1969	4143745	No
1413	3168	1584.0	89.56	44.8	The mirror-neuron system.	Giacomo Rizzolatti, Laila Craighero	Annu Rev Neurosci	2004	15217330	No
1414	3167	1583.5	113.21	56.6	Avoiding false positives with PCR.	S Kwok, R Higuchi	Nature	1989	2716852	Yes
1415	1583	1583.0	39.95	40.0	Tumor necrosis factor (TNF).	L J Old	Science	1985	2413547	Yes
1416	1582	1582.0	48.06	48.1	Classification of inflammatory bowel disease.	J E Lennard-Jones	Scand J Gastroenterol Suppl	1989	2617184	Yes
1417	1582	1582.0	0.0	0.0	Structural considerations in the interaction of DNA and acridines.	L S Lerman	J Mol Biol	1961	13761054	Yes
1418	1582	1582.0	43.33	43.3	The genetics of ageing.	Cynthia J Kenyon	Nature	2010	20336132	No
1419	1581	1581.0	34.63	34.6	The caveolae membrane system.	R G Anderson	Annu Rev Biochem	1998	9759488	No
1420	1580	1580.0	0.0	0.0	Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment.	K O Fagerström	Addict Behav	1978	735910	Yes
1421	1580	1580.0	37.78	37.8	Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems.	S A Bustin	J Mol Endocrinol	2002	12200227	No
1422	1579	1579.0	42.86	42.9	Using circular dichroism spectra to estimate protein secondary structure.	Norma J Greenfield	Nat Protoc	2006	17406547	Yes
1423	1579	1579.0	55.74	55.7	Grounded cognition.	Lawrence W Barsalou	Annu Rev Psychol	2008	17705682	No
1424	1578	1578.0	45.55	45.5	Ionic dependence of glutamate neurotoxicity.	D W Choi	J Neurosci	1987	2880938	Yes
1425	1578	1578.0	33.03	33.0	The synaptic vesicle cycle.	Thomas C Sudhof	Annu Rev Neurosci	2004	15217342	No
1426	1577	1577.0	0.0	0.0	Interhemispheric differences in the localization of psychological processes in man.	B Milner	Br Med Bull	1971	4937273	No
1427	3154	1577.0	78.16	39.1	CAP3: A DNA sequence assembly program.	X Huang, A Madan	Genome Res	1999	10508846	Yes
1428	3154	1577.0	90.92	45.5	Biofilms: survival mechanisms of clinically relevant microorganisms.	Rodney M Donlan, J William Costerton	Clin Microbiol Rev	2002	11932229	No
1429	3152	1576.0	78.08	39.0	A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes.	S Tabor, C C Richardson	Proc Natl Acad Sci U S A	1985	3156376	Yes
1430	3152	1576.0	68.17	34.1	Inhibitors of mammalian G1 cyclin-dependent kinases.	C J Sherr, J M Roberts	Genes Dev	1995	7758941	No
1431	1576	1576.0	44.29	44.3	Network pharmacology: the next paradigm in drug discovery.	Andrew L Hopkins	Nat Chem Biol	2008	18936753	No
1432	3149	1574.5	91.44	45.7	ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT.	B Ravel, M Newville	J Synchrotron Radiat	2005	15968136	Yes
1433	1574	1574.0	0.0	0.0	Computerized transverse axial scanning (tomography). 1. Description of system.	G N Hounsfield	Br J Radiol	1973	4757352	Yes
1434	1574	1574.0	53.23	53.2	Number of people with glaucoma worldwide.	H A Quigley	Br J Ophthalmol	1996	8695555	No
1435	1573	1573.0	40.77	40.8	Angiogenesis: an organizing principle for drug discovery?	Judah Folkman	Nat Rev Drug Discov	2007	17396134	No
1436	4716	1572.0	113.33	37.8	Inflammation and atherosclerosis.	Peter Libby, Paul M Ridker, Attilio Maseri	Circulation	2002	11877368	No
1437	10994	1570.6	285.62	40.8	Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.	William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan	N Engl J Med	2002	11832527	Yes
1438	1570	1570.0	52.36	52.4	Biology of interleukin 1.	C A Dinarello	FASEB J	1988	3277884	No
1439	3140	1570.0	88.5	44.2	Polyamines.	C W Tabor, H Tabor	Annu Rev Biochem	1984	6206782	No
1440	1568	1568.0	41.3	41.3	Alpha-crystallin can function as a molecular chaperone.	J Horwitz	Proc Natl Acad Sci U S A	1992	1438232	Yes
1441	3136	1568.0	0.0	0.0	A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues.	G Schmidt, S J Thannhauser	J Biol Chem	1945	21005717	Yes
1442	1566	1566.0	0.0	0.0	Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.	B Hille	J Gen Physiol	1977	300786	Yes
1443	1566	1566.0	46.19	46.2	Perceptual symbol systems.	L W Barsalou	Behav Brain Sci	1999	11301525	No
1444	1566	1566.0	0.0	0.0	The estimation of phosphorus.	R J Allen	Biochem J	1940	16747230	Yes
1445	1565	1565.0	0.0	0.0	Regulation of noradrenaline release by presynaptic receptor systems.	K Starke	Rev Physiol Biochem Pharmacol	1977	14389	No
1446	4695	1565.0	103.94	34.6	Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.	J E Darnell, I M Kerr, G R Stark	Science	1994	8197455	No
1447	1565	1565.0	34.58	34.6	Excitatory actions of gaba during development: the nature of the nurture.	Yehezkel Ben-Ari	Nat Rev Neurosci	2002	12209121	No
1448	3129	1564.5	97.59	48.8	Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.	D S Bredt, S H Snyder	Proc Natl Acad Sci U S A	1990	1689048	Yes
1449	1563	1563.0	34.19	34.2	On finding all suboptimal foldings of an RNA molecule.	M Zuker	Science	1989	2468181	No
1450	1563	1563.0	0.0	0.0	A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin.	B C Hummel	Can J Biochem Physiol	1959	14405350	Yes
1451	3125	1562.5	91.43	45.7	Building better batteries.	M Armand, J-M Tarascon	Nature	2008	18256660	No
1452	1561	1561.0	0.0	0.0	Fluorescence energy transfer as a spectroscopic ruler.	L Stryer	Annu Rev Biochem	1978	354506	No
1453	1561	1561.0	71.93	71.9	Mood and memory.	G H Bower	Am Psychol	1981	7224324	Yes
1454	1560	1560.0	0.0	0.0	Paced auditory serial-addition task: a measure of recovery from concussion.	D M Gronwall	Percept Mot Skills	1977	866038	Yes
1455	3120	1560.0	63.27	31.6	SIFT: Predicting amino acid changes that affect protein function.	Pauline C Ng, Steven Henikoff	Nucleic Acids Res	2003	12824425	Yes
1456	1559	1559.0	55.31	55.3	Frontal-subcortical circuits and human behavior.	J L Cummings	Arch Neurol	1993	8352676	No
1457	3118	1559.0	69.44	34.7	Insulin signalling and the regulation of glucose and lipid metabolism.	A R Saltiel, C R Kahn	Nature	2001	11742412	Yes
1458	1558	1558.0	42.97	43.0	The complete general secretory pathway in gram-negative bacteria.	A P Pugsley	Microbiol Rev	1993	8096622	No
1459	1558	1558.0	35.91	35.9	The proto-oncogene Bcl-2 and its role in regulating apoptosis.	G Kroemer	Nat Med	1997	9176486	No
1460	1558	1558.0	53.66	53.7	Hypoxia-inducible factors in physiology and medicine.	Gregg L Semenza	Cell	2012	22304911	No
1461	3115	1557.5	141.07	70.5	miRBase: annotating high confidence microRNAs using deep sequencing data.	Ana Kozomara, Sam Griffiths-Jones	Nucleic Acids Res	2014	24275495	Yes
1462	1557	1557.0	61.72	61.7	Modeling and variable selection in epidemiologic analysis.	S Greenland	Am J Public Health	1989	2916724	Yes
1463	1557	1557.0	0.0	0.0	Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection.	W H Oldendorf	Am J Physiol	1971	5124307	Yes
1464	1556	1556.0	48.54	48.5	Infrared spectroscopy of proteins.	Andreas Barth	Biochim Biophys Acta	2007	17692815	No
1465	6223	1555.8	169.93	42.5	Cancer-related inflammation.	Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill	Nature	2008	18650914	No
1466	1555	1555.0	33.33	33.3	Points of control in inflammation.	Carl Nathan	Nature	2002	12490957	No
1467	4664	1554.7	133.19	44.4	Cell death: the significance of apoptosis.	A H Wyllie, J F Kerr, A R Currie	Int Rev Cytol	1980	7014501	No
1468	3108	1554.0	0.0	0.0	Convergent and discriminant validation by the multitrait-multimethod matrix.	D T Campbell, D W Fiske	Psychol Bull	1959	13634291	Yes
1469	1554	1554.0	39.82	39.8	Tumor angiogenesis.	Robert S Kerbel	N Engl J Med	2008	18463380	No
1470	4660	1553.3	144.94	48.3	Atrial fibrillation as an independent risk factor for stroke: the Framingham Study.	P A Wolf, R D Abbott, W B Kannel	Stroke	1991	1866765	Yes
1471	3104	1552.0	94.15	47.1	Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons.	M Karas, F Hillenkamp	Anal Chem	1988	3239801	Yes
1472	1551	1551.0	41.69	41.7	Adipose tissue, adipokines, and inflammation.	Giamila Fantuzzi	J Allergy Clin Immunol	2005	15867843	No
1473	4652	1550.7	189.11	63.0	The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs.	C A McHorney, J E Ware, A E Raczek	Med Care	1993	8450681	Yes
1474	1550	1550.0	0.0	0.0	The relationship between the spleen colony-forming cell and the haemopoietic stem cell.	R Schofield	Blood Cells	1978	747780	Yes
1475	1550	1550.0	29.65	29.6	Germinal centers.	I C MacLennan	Annu Rev Immunol	1994	8011279	No
1476	1550	1550.0	31.45	31.4	Generating samples under a Wright-Fisher neutral model of genetic variation.	Richard R Hudson	Bioinformatics	2002	11847089	Yes
1477	1550	1550.0	32.61	32.6	Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.	Judith Campisi	Cell	2005	15734683	No
1478	1549	1549.0	52.57	52.6	Archaea in coastal marine environments.	E F DeLong	Proc Natl Acad Sci U S A	1992	1608980	Yes
1479	1549	1549.0	45.18	45.2	Glycosphingolipids in cellular interaction, differentiation, and oncogenesis.	S Hakomori	Annu Rev Biochem	1981	7023369	No
1480	4646	1548.7	0.0	0.0	A highly sensitive adenylate cyclase assay.	Y Salomon, C Londos, M Rodbell	Anal Biochem	1974	4827395	Yes
1481	1548	1548.0	41.95	42.0	Molecular bases of the acute coronary syndromes.	P Libby	Circulation	1995	7758192	No
1482	1548	1548.0	51.42	51.4	Health consequences of obesity in youth: childhood predictors of adult disease.	W H Dietz	Pediatrics	1998	12224658	No
1483	1548	1548.0	34.3	34.3	Protein homology detection by HMM-HMM comparison.	Johannes Söding	Bioinformatics	2005	15531603	Yes
1484	4643	1547.7	101.66	33.9	A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays.	Zhang, Chung, Oldenburg	J Biomol Screen	1999	10838414	Yes
1485	3093	1546.5	206.83	103.4	A clinical method of functional assessment of the shoulder.	C R Constant, A H Murley	Clin Orthop Relat Res	1987	3791738	Yes
1486	1545	1545.0	40.17	40.2	Molecular biology of prion diseases.	S B Prusiner	Science	1991	1675487	No
1487	1545	1545.0	45.39	45.4	The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function.	R R Llinás	Science	1988	3059497	No
1488	1545	1545.0	60.36	60.4	Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides.	P Holzer	Neuroscience	1988	3288903	No
1489	4633	1544.3	104.98	35.0	An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database.	J K Eng, A L McCormack, J R Yates	J Am Soc Mass Spectrom	1994	24226387	Yes
1490	1544	1544.0	43.98	44.0	Leptospirosis.	P N Levett	Clin Microbiol Rev	2001	11292640	No
1491	3086	1543.0	65.62	32.8	A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids.	D Wessel, U I Flügge	Anal Biochem	1984	6731838	Yes
1492	1543	1543.0	37.23	37.2	Recognition of microorganisms and activation of the immune response.	Ruslan Medzhitov	Nature	2007	17943118	No
1493	1542	1542.0	60.45	60.5	Simple proton spectroscopic imaging.	W T Dixon	Radiology	1984	6089263	Yes
1494	1542	1542.0	38.19	38.2	HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy.	J M Coffin	Science	1995	7824947	Yes
1495	1542	1542.0	49.92	49.9	Cellular defenses against damage from reactive oxygen species.	B P Yu	Physiol Rev	1994	8295932	No
1496	1542	1542.0	48.85	48.9	Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance.	F Rousset	Genetics	1997	9093870	Yes
1497	1541	1541.0	51.58	51.6	Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue').	M N Marsh	Gastroenterology	1992	1727768	No
1498	1541	1541.0	0.0	0.0	Discharge patterns and functional organization of mammalian retina.	S W Kuffler	J Neurophysiol	1953	13035466	Yes
1499	1540	1540.0	34.14	34.1	Neuronal calcium signaling.	M J Berridge	Neuron	1998	9697848	No
1500	1540	1540.0	44.17	44.2	Oxidative stress and neurodegeneration: where are we now?	Barry Halliwell	J Neurochem	2006	16805774	No
1501	1540	1540.0	61.35	61.4	Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope.	Lutz Ackermann	Chem Rev	2011	21391562	Yes
1502	3079	1539.5	90.62	45.3	Oxidative stress, glutamate, and neurodegenerative disorders.	J T Coyle, P Puttfarcken	Science	1993	7901908	No
1503	4618	1539.3	131.75	43.9	The metabolic syndrome--a new worldwide definition.	K George M M Alberti, Paul Zimmet, Jonathan Shaw	Lancet	2005	16182882	Yes
1504	1539	1539.0	0.0	0.0	Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase.	H S Penefsky	J Biol Chem	1977	16006	Yes
1505	1538	1538.0	30.36	30.4	Switching and signaling at the telomere.	E H Blackburn	Cell	2001	11572773	No
1506	4611	1537.0	103.48	34.5	Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.	M A Frohman, M K Dush, G R Martin	Proc Natl Acad Sci U S A	1988	2461560	Yes
1507	3074	1537.0	122.41	61.2	The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger.	A J Stunkard, S Messick	J Psychosom Res	1985	3981480	Yes
1508	1537	1537.0	66.63	66.6	The drug abuse screening test.	H A Skinner	Addict Behav	1982	7183189	Yes
1509	1535	1535.0	34.76	34.8	Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.	C Taswell	J Immunol	1981	7009746	Yes
1510	1535	1535.0	50.17	50.2	The stress response in fish.	S E Wendelaar Bonga	Physiol Rev	1997	9234959	No
1511	1535	1535.0	41.9	41.9	From sensation to cognition.	M M Mesulam	Brain	1998	9648540	No
1512	1534	1534.0	0.0	0.0	Antigen-Antibody Crossed Electrophoresis.	C B Laurell	Anal Biochem	1965	14302464	Yes
1513	1533	1533.0	44.57	44.6	Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.	A E Pegg	Cancer Res	1988	3123052	No
1514	3065	1532.5	104.3	52.1	Understanding interobserver agreement: the kappa statistic.	Anthony J Viera, Joanne M Garrett	Fam Med	2005	15883903	Yes
1515	3063	1531.5	76.62	38.3	Neuronal oscillations in cortical networks.	György Buzsáki, Andreas Draguhn	Science	2004	15218136	No
1516	4592	1530.7	0.0	0.0	Impact of Event Scale: a measure of subjective stress.	M Horowitz, N Wilner, W Alvarez	Psychosom Med	1979	472086	Yes
1517	4591	1530.3	118.21	39.4	Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey.	Earl S Ford, Wayne H Giles, William H Dietz	JAMA	2002	11790215	Yes
1518	3058	1529.0	0.0	0.0	The structure of coping.	L I Pearlin, C Schooler	J Health Soc Behav	1978	649936	Yes
1519	1529	1529.0	38.98	39.0	Early signals in the mitogenic response.	E Rozengurt	Science	1986	3018928	No
1520	1529	1529.0	39.33	39.3	Cellular basis of working memory.	P S Goldman-Rakic	Neuron	1995	7695894	No
1521	1529	1529.0	27.49	27.5	Cell cycle checkpoint signaling through the ATM and ATR kinases.	R T Abraham	Genes Dev	2001	11544175	No
1522	1529	1529.0	45.74	45.7	Introduction and General Overview of Cyclodextrin Chemistry.	József Szejtli	Chem Rev	1998	11848947	Yes
1523	3058	1529.0	94.16	47.1	The unfolded protein response: from stress pathway to homeostatic regulation.	Peter Walter, David Ron	Science	2011	22116877	No
1524	3057	1528.5	72.88	36.4	Issues and challenges facing rechargeable lithium batteries.	J M Tarascon, M Armand	Nature	2001	11713543	Yes
1525	1527	1527.0	0.0	0.0	An enzymic method for the trace iodination of immunoglobulins and other proteins.	J J Marchalonis	Biochem J	1969	4185494	Yes
1526	3052	1526.0	0.0	0.0	Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome.	C B Lozzio, B B Lozzio	Blood	1975	163658	Yes
1527	1526	1526.0	36.66	36.7	AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.	D Grahame Hardie	Nat Rev Mol Cell Biol	2007	17712357	No
1528	3051	1525.5	0.0	0.0	New Giemsa method for the differential staining of sister chromatids.	P Perry, S Wolff	Nature	1974	4138930	Yes
1529	3051	1525.5	89.46	44.7	Event-related EEG/MEG synchronization and desynchronization: basic principles.	G Pfurtscheller, F H Lopes da Silva	Clin Neurophysiol	1999	10576479	No
1530	1525	1525.0	30.62	30.6	E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.	J R Nevins	Science	1992	1411535	Yes
1531	1525	1525.0	34.27	34.3	Molecular themes in oncogenesis.	J M Bishop	Cell	1991	1988146	No
1532	1525	1525.0	45.4	45.4	Recent advances in the biochemistry of polyamines in eukaryotes.	A E Pegg	Biochem J	1986	3087344	No
1533	9149	1524.8	216.9	36.1	Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.	D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuire	Science	1987	3798106	Yes
1534	3049	1524.5	103.78	51.9	The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today.	R Doll, R Peto	J Natl Cancer Inst	1981	7017215	No
1535	3044	1522.0	71.83	35.9	The epigenomics of cancer.	Peter A Jones, Stephen B Baylin	Cell	2007	17320506	No
1536	1521	1521.0	46.1	46.1	Multiple imputation: a primer.	J L Schafer	Stat Methods Med Res	1999	10347857	No
1537	1520	1520.0	39.22	39.2	Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations.	M J Meaney	Annu Rev Neurosci	2001	11520931	No
1538	1519	1519.0	41.59	41.6	Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.	L A Liotta	Cancer Res	1986	2998604	No
1539	1519	1519.0	70.35	70.3	The contribution of low birth weight to infant mortality and childhood morbidity.	M C McCormick	N Engl J Med	1985	3880598	No
1540	1519	1519.0	40.84	40.8	Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp.	D A Dougherty	Science	1996	8539615	No
1541	1519	1519.0	0.0	0.0	Dithiothreitol, A New Protective Reagent For Sh Groups.	W W Cleland	Biochemistry	1964	14192894	Yes
1542	1519	1519.0	49.37	49.4	Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events?	George A Bonanno	Am Psychol	2004	14736317	No
1543	1516	1516.0	70.79	70.8	Measurement of health state utilities for economic appraisal.	G W Torrance	J Health Econ	1986	10311607	No
1544	1515	1515.0	0.0	0.0	Which elements are excited in electrical stimulation of mammalian central nervous system: a review.	J B Ranck	Brain Res	1975	1102064	No
1545	1515	1515.0	38.21	38.2	Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods.	Z Yang	J Mol Evol	1994	7932792	Yes
1546	1515	1515.0	44.52	44.5	The in vitro micronucleus technique.	M Fenech	Mutat Res	2000	11113469	No
1547	1514	1514.0	0.0	0.0	Calcium release from the sarcoplasmic reticulum.	M Endo	Physiol Rev	1977	13441	Yes
1548	1514	1514.0	27.62	27.6	Altering the genome by homologous recombination.	M R Capecchi	Science	1989	2660260	No
1549	3026	1513.0	83.77	41.9	Angiogenesis.	J Folkman, Y Shing	J Biol Chem	1992	1375931	No
1550	9078	1513.0	192.81	32.1	Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.	A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C Mello	Nature	1998	9486653	Yes
1551	1513	1513.0	38.13	38.1	The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.	Michael R Lieber	Annu Rev Biochem	2010	20192759	No
1552	9060	1510.0	314.5	52.4	Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.	L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R Tannenbaum	Anal Biochem	1982	7181105	Yes
1553	3019	1509.5	111.12	55.6	ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts.	M Gardes, T D Bruns	Mol Ecol	1993	8180733	Yes
1554	1509	1509.0	36.4	36.4	Getting formal with dopamine and reward.	Wolfram Schultz	Neuron	2002	12383780	No
1555	1507	1507.0	80.3	80.3	Conservation of resources. A new attempt at conceptualizing stress.	S E Hobfoll	Am Psychol	1989	2648906	No
1556	3013	1506.5	0.0	0.0	Computed circular dichroism spectra for the evaluation of protein conformation.	N Greenfield, G D Fasman	Biochemistry	1969	5346390	Yes
1557	3013	1506.5	60.22	30.1	Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.	O Tetsu, F McCormick	Nature	1999	10201372	Yes
1558	3012	1506.0	100.56	50.3	Separate visual pathways for perception and action.	M A Goodale, A D Milner	Trends Neurosci	1992	1374953	No
1559	3012	1506.0	0.0	0.0	Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration.	D B Dill, D L Costill	J Appl Physiol	1974	4850854	Yes
1560	1504	1504.0	0.0	0.0	Biological applications of ionophores.	B C Pressman	Annu Rev Biochem	1976	786156	No
1561	1504	1504.0	29.05	29.1	How cells read TGF-beta signals.	J Massagué	Nat Rev Mol Cell Biol	2000	11252892	No
1562	1504	1504.0	43.31	43.3	Determination of minimum inhibitory concentrations.	J M Andrews	J Antimicrob Chemother	2001	11420333	Yes
1563	3008	1504.0	64.13	32.1	Upstream and downstream of mTOR.	Nissim Hay, Nahum Sonenberg	Genes Dev	2004	15314020	No
1564	1503	1503.0	0.0	0.0	Some observations upon a new inhibitor of monoamine oxidase in brain tissue.	J P Johnston	Biochem Pharmacol	1968	5659776	Yes
1565	1503	1503.0	56.85	56.9	Aging, natural death, and the compression of morbidity.	J F Fries	N Engl J Med	1980	7383070	Yes
1566	3006	1503.0	80.41	40.2	Origins and Mechanisms of miRNAs and siRNAs.	Richard W Carthew, Erik J Sontheimer	Cell	2009	19239886	No
1567	1500	1500.0	59.47	59.5	Probiotics in man and animals.	R Fuller	J Appl Bacteriol	1989	2666378	No
1568	1500	1500.0	37.86	37.9	Trophic factors and neuronal survival.	Y A Barde	Neuron	1989	2697237	No
1569	1500	1500.0	42.16	42.2	Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy.	Y Ben-Ari	Neuroscience	1985	2859548	No
1570	1500	1500.0	43.7	43.7	Oxidative stress: oxidants and antioxidants.	H Sies	Exp Physiol	1997	9129943	No
1571	1499	1499.0	66.57	66.6	A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability.	D J Schuirmann	J Pharmacokinet Biopharm	1987	3450848	Yes
1572	1498	1498.0	36.03	36.0	Trastuzumab--mechanism of action and use in clinical practice.	Clifford A Hudis	N Engl J Med	2007	17611206	No
1573	1496	1496.0	44.25	44.2	The basal ganglia: focused selection and inhibition of competing motor programs.	J W Mink	Prog Neurobiol	1996	9004351	No
1574	11968	1496.0	319.21	39.9	Electric field effect in atomically thin carbon films.	K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A Firsov	Science	2004	15499015	Yes
1575	1496	1496.0	44.99	45.0	Porous scaffold design for tissue engineering.	Scott J Hollister	Nat Mater	2005	16003400	No
1576	5981	1495.2	0.0	0.0	The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care.	S P Baker, B O'Neill, W Haddon, W B Long	J Trauma	1974	4814394	Yes
1577	1495	1495.0	30.6	30.6	The ubiquitin-proteasome proteolytic pathway.	A Ciechanover	Cell	1994	7923371	No
1578	1494	1494.0	47.4	47.4	The role of the amygdala in fear and anxiety.	M Davis	Annu Rev Neurosci	1992	1575447	No
1579	1494	1494.0	30.05	30.1	Neuroblastoma: biological insights into a clinical enigma.	Garrett M Brodeur	Nat Rev Cancer	2003	12612655	No
1580	2988	1494.0	65.28	32.6	Signaling to NF-kappaB.	Matthew S Hayden, Sankar Ghosh	Genes Dev	2004	15371334	No
1581	1493	1493.0	41.05	41.0	THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons.	Kozi Asada	Annu Rev Plant Physiol Plant Mol Biol	1999	15012221	Yes
1582	1493	1493.0	41.74	41.7	P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation.	Berk Hess	J Chem Theory Comput	2008	26619985	Yes
1583	2985	1492.5	82.85	41.4	A scaling normalization method for differential expression analysis of RNA-seq data.	Mark D Robinson, Alicia Oshlack	Genome Biol	2010	20196867	Yes
1584	1492	1492.0	0.0	0.0	The inverse care law.	J T Hart	Lancet	1971	4100731	Yes
1585	1492	1492.0	0.0	0.0	Dopamine (3-hydroxytyramine) and brain function.	O Hornykiewicz	Pharmacol Rev	1966	5328389	No
1586	1492	1492.0	37.36	37.4	Python: a programming language for software integration and development.	M F Sanner	J Mol Graph Model	1999	10660911	Yes
1587	1491	1491.0	39.39	39.4	The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.	A S Fauci	Science	1988	3277274	No
1588	4473	1491.0	121.61	40.5	Median-joining networks for inferring intraspecific phylogenies.	H J Bandelt, P Forster, A Röhl	Mol Biol Evol	1999	10331250	Yes
1589	1491	1491.0	36.54	36.5	Thiazolidinediones.	Hannele Yki-Järvinen	N Engl J Med	2004	15356308	No
1590	2981	1490.5	74.18	37.1	Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry.	Robert Visse, Hideaki Nagase	Circ Res	2003	12730128	No
1591	2980	1490.0	156.96	78.5	Interrater reliability of a modified Ashworth scale of muscle spasticity.	R W Bohannon, M B Smith	Phys Ther	1987	3809245	Yes
1592	5957	1489.2	232.25	58.1	SignalP 4.0: discriminating signal peptides from transmembrane regions.	Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik Nielsen	Nat Methods	2011	21959131	Yes
1593	1489	1489.0	0.0	0.0	Synaptic density in human frontal cortex - developmental changes and effects of aging.	P R Huttenlocher	Brain Res	1979	427544	Yes
1594	1489	1489.0	31.06	31.1	Network motifs: theory and experimental approaches.	Uri Alon	Nat Rev Genet	2007	17510665	No
1595	1488	1488.0	56.06	56.1	The linear-quadratic formula and progress in fractionated radiotherapy.	J F Fowler	Br J Radiol	1989	2670032	No
1596	1488	1488.0	33.53	33.5	Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1.	G L Semenza	Annu Rev Cell Dev Biol	1999	10611972	No
1597	1487	1487.0	0.0	0.0	Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.	J C Unkeless	J Exp Med	1979	90108	Yes
1598	1487	1487.0	0.0	0.0	Bias in analytic research.	D L Sackett	J Chronic Dis	1979	447779	Yes
1599	1487	1487.0	35.44	35.4	Hypertrophic cardiomyopathy: a systematic review.	Barry J Maron	JAMA	2002	11886323	No
1600	1487	1487.0	37.06	37.1	The retinal pigment epithelium in visual function.	Olaf Strauss	Physiol Rev	2005	15987797	No
1601	7433	1486.6	198.39	39.7	Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.	Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan Hsu	N Engl J Med	2004	15385656	Yes
1602	2973	1486.5	0.0	0.0	Lactic dehydrogenase activity in blood.	F Wroblewski, J S Ladue	Proc Soc Exp Biol Med	1955	13273400	Yes
1603	1486	1486.0	52.36	52.4	Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges.	Leonardo Pantoni	Lancet Neurol	2010	20610345	No
1604	1485	1485.0	0.0	0.0	Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies.	S Avrameas	Immunochemistry	1969	4975324	Yes
1605	1485	1485.0	30.38	30.4	The microRNA Registry.	Sam Griffiths-Jones	Nucleic Acids Res	2004	14681370	Yes
1606	4449	1483.0	95.12	31.7	The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.	S K Hanks, A M Quinn, T Hunter	Science	1988	3291115	No
1607	1483	1483.0	0.0	0.0	A soluble protein characteristic of the nervous system.	B W Moore	Biochem Biophys Res Commun	1965	4953930	Yes
1608	1482	1482.0	38.19	38.2	The corticosteroid receptor hypothesis of depression.	F Holsboer	Neuropsychopharmacology	2000	11027914	No
1609	1481	1481.0	0.0	0.0	Simple methods for "staining with lead" at high pH in electron microscopy.	M J Karnovsky	J Biophys Biochem Cytol	1961	14454024	Yes
1610	2962	1481.0	66.97	33.5	Why do cancers have high aerobic glycolysis?	Robert A Gatenby, Robert J Gillies	Nat Rev Cancer	2004	15516961	No
1611	1481	1481.0	46.24	46.2	Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.	Ralph A Defronzo	Diabetes	2009	19336687	No
1612	2960	1480.0	107.9	54.0	Macrophage plasticity and polarization: in vivo veritas.	Antonio Sica, Alberto Mantovani	J Clin Invest	2012	22378047	No
1613	8877	1479.5	279.49	46.6	Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication.	Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E Walters	Arch Gen Psychiatry	2005	15939837	Yes
1614	1479	1479.0	52.0	52.0	Lyme disease.	A C Steere	N Engl J Med	1989	2668764	No
1615	1479	1479.0	38.5	38.5	Growth of the plant cell wall.	Daniel J Cosgrove	Nat Rev Mol Cell Biol	2005	16261190	No
1616	4435	1478.3	89.68	29.9	Efficient selection for high-expression transfectants with a novel eukaryotic vector.	H Niwa, K Yamamura, J Miyazaki	Gene	1991	1660837	Yes
1617	1478	1478.0	0.0	0.0	The colorimetric determination of phosphorus.	E J King	Biochem J	1932	16744823	Yes
1618	2955	1477.5	75.73	37.9	The BCL-2 protein family: opposing activities that mediate cell death.	Richard J Youle, Andreas Strasser	Nat Rev Mol Cell Biol	2008	18097445	No
1619	1477	1477.0	33.66	33.7	Tumor suppressor genes.	R A Weinberg	Science	1991	1659741	No
1620	1477	1477.0	39.98	40.0	Rheumatoid arthritis. Pathophysiology and implications for therapy.	E D Harris	N Engl J Med	1990	2271017	No
1621	2953	1476.5	0.0	0.0	The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.	E G Gray, V P Whittaker	J Anat	1962	13901297	Yes
1622	5905	1476.2	289.39	72.3	jModelTest 2: more models, new heuristics and parallel computing.	Diego Darriba, Guillermo L Taboada, Ramón Doallo, David Posada	Nat Methods	2012	22847109	Yes
1623	1476	1476.0	36.48	36.5	Recognition of errors in three-dimensional structures of proteins.	M J Sippl	Proteins	1993	8108378	Yes
1624	1476	1476.0	44.18	44.2	Molecular dissection of reactive astrogliosis and glial scar formation.	Michael V Sofroniew	Trends Neurosci	2009	19782411	No
1625	1475	1475.0	0.0	0.0	Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report.	C S Neer	J Bone Joint Surg Am	1972	5054450	Yes
1626	1475	1475.0	0.0	0.0	The recurrence of intracranial meningiomas after surgical treatment.	D Simpson	J Neurol Neurosurg Psychiatry	1957	13406590	Yes
1627	2946	1473.0	58.94	29.5	Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins.	P J Mitchell, R Tjian	Science	1989	2667136	No
1628	1472	1472.0	36.53	36.5	A revolution in optical manipulation.	David G Grier	Nature	2003	12917694	No
1629	1472	1472.0	43.88	43.9	Trail Making Test A and B: normative data stratified by age and education.	Tom N Tombaugh	Arch Clin Neuropsychol	2004	15010086	Yes
1630	1472	1472.0	44.01	44.0	What we can do and what we cannot do with fMRI.	Nikos K Logothetis	Nature	2008	18548064	No
1631	2943	1471.5	72.7	36.4	Human mesenchymal stem cells modulate allogeneic immune cell responses.	Sudeepta Aggarwal, Mark F Pittenger	Blood	2005	15494428	Yes
1632	1471	1471.0	0.0	0.0	Isolated removal of hypothalamic or other brain nuclei of the rat.	M Palkovits	Brain Res	1973	4747772	Yes
1633	1471	1471.0	50.19	50.2	A new automated colorimetric method for measuring total oxidant status.	Ozcan Erel	Clin Biochem	2005	16214125	Yes
1634	1470	1470.0	0.0	0.0	Simple memory: a theory for archicortex.	D Marr	Philos Trans R Soc Lond B Biol Sci	1971	4399412	Yes
1635	1470	1470.0	41.31	41.3	Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum.	A Fabiato	Am J Physiol	1983	6346892	No
1636	1470	1470.0	0.0	0.0	Application of a Theory of Enzyme Specificity to Protein Synthesis.	D E Koshland	Proc Natl Acad Sci U S A	1958	16590179	Yes
1637	2939	1469.5	69.01	34.5	Fibroblasts in cancer.	Raghu Kalluri, Michael Zeisberg	Nat Rev Cancer	2006	16572188	No
1638	2939	1469.5	73.58	36.8	The DNA-damage response in human biology and disease.	Stephen P Jackson, Jiri Bartek	Nature	2009	19847258	No
1639	2937	1468.5	114.52	57.3	Microenvironmental regulation of tumor progression and metastasis.	Daniela F Quail, Johanna A Joyce	Nat Med	2013	24202395	No
1640	1467	1467.0	0.0	0.0	Atherogenesis: a postprandial phenomenon.	D B Zilversmit	Circulation	1979	222498	Yes
1641	4401	1467.0	180.81	60.3	Effect of the damping function in dispersion corrected density functional theory.	Stefan Grimme, Stephan Ehrlich, Lars Goerigk	J Comput Chem	2011	21370243	Yes
1642	4398	1466.0	153.66	51.2	A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study.	J R Le Gall, S Lemeshow, F Saulnier	JAMA	1993	8254858	Yes
1643	2931	1465.5	62.07	31.0	Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases.	Gary L Johnson, Razvan Lapadat	Science	2002	12471242	No
1644	2929	1464.5	0.0	0.0	Junctional complexes in various epithelia.	M G Farquhar, G E Palade	J Cell Biol	1963	13944428	Yes
1645	1464	1464.0	0.0	0.0	Cerebral blood flow and oxygen consumption in man.	N A Lassen	Physiol Rev	1959	13645234	Yes
1646	2928	1464.0	0.0	0.0	A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines.	A H Anton, D F Sayre	J Pharmacol Exp Ther	1962	14013351	Yes
1647	2927	1463.5	0.0	0.0	A general method for isolation of high molecular weight DNA from eukaryotes.	N Blin, D W Stafford	Nucleic Acids Res	1976	987581	Yes
1648	1463	1463.0	49.25	49.2	Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson.	H J Gundersen	J Microsc	1986	3761363	Yes
1649	1462	1462.0	35.56	35.6	Introduction to NF-kappaB: players, pathways, perspectives.	T D Gilmore	Oncogene	2006	17072321	No
1650	2923	1461.5	92.28	46.1	Autophagy: renovation of cells and tissues.	Noboru Mizushima, Masaaki Komatsu	Cell	2011	22078875	No
1651	1461	1461.0	39.12	39.1	Precision mapping of quantitative trait loci.	Z B Zeng	Genetics	1994	8013918	Yes
1652	4380	1460.0	0.0	0.0	The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes.	J T Dodge, C Mitchell, D J Hanahan	Arch Biochem Biophys	1963	14028302	Yes
1653	1460	1460.0	46.2	46.2	Gold-catalyzed organic reactions.	A Stephen K Hashmi	Chem Rev	2007	17580975	Yes
1654	1459	1459.0	33.6	33.6	Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone.	M B Luskin	Neuron	1993	8338665	Yes
1655	1459	1459.0	0.0	0.0	Cognitive maps in rats and men.	E C Tolman	Psychol Rev	1948	18870876	Yes
1656	4377	1459.0	116.56	38.9	Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm.	Prateek Kumar, Steven Henikoff, Pauline C Ng	Nat Protoc	2009	19561590	Yes
1657	1458	1458.0	25.31	25.3	Neuronal specification in the spinal cord: inductive signals and transcriptional codes.	T M Jessell	Nat Rev Genet	2000	11262869	No
1658	2914	1457.0	65.76	32.9	Cell migration: a physically integrated molecular process.	D A Lauffenburger, A F Horwitz	Cell	1996	8608589	No
1659	16027	1457.0	437.6	39.8	PLINK: a tool set for whole-genome association and population-based linkage analyses.	Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C Sham	Am J Hum Genet	2007	17701901	Yes
1660	7280	1456.0	167.83	33.6	Stages of embryonic development of the zebrafish.	C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F Schilling	Dev Dyn	1995	8589427	Yes
1661	1456	1456.0	31.73	31.7	DNA in a material world.	Nadrian C Seeman	Nature	2003	12540916	No
1662	4367	1455.7	89.01	29.7	T-Coffee: A novel method for fast and accurate multiple sequence alignment.	C Notredame, D G Higgins, J Heringa	J Mol Biol	2000	10964570	Yes
1663	7277	1455.4	184.5	36.9	Development and testing of a general amber force field.	Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A Case	J Comput Chem	2004	15116359	Yes
1664	5819	1454.8	0.0	0.0	A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples.	M A Markwell, S M Haas, L L Bieber, N E Tolbert	Anal Biochem	1978	98070	Yes
1665	2909	1454.5	68.49	34.2	Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.	C Auffray, F Rougeon	Eur J Biochem	1980	6772444	Yes
1666	4363	1454.3	150.61	50.2	Phylogenetic identification and in situ detection of individual microbial cells without cultivation.	R I Amann, W Ludwig, K H Schleifer	Microbiol Rev	1995	7535888	No
1667	4363	1454.3	84.18	28.1	Notch signaling: cell fate control and signal integration in development.	S Artavanis-Tsakonas, M D Rand, R J Lake	Science	1999	10221902	No
1668	1454	1454.0	0.0	0.0	Chemoaffinity In The Orderly Growth Of Nerve Fiber Patterns And Connections.	R W Sperry	Proc Natl Acad Sci U S A	1963	14077501	Yes
1669	1454	1454.0	37.99	38.0	Tricine-SDS-PAGE.	Hermann Schägger	Nat Protoc	2006	17406207	Yes
1670	1453	1453.0	0.0	0.0	Selforganization of matter and the evolution of biological macromolecules.	M Eigen	Naturwissenschaften	1971	4942363	No
1671	5809	1452.2	289.04	72.3	The Satisfaction With Life Scale.	E Diener, R A Emmons, R J Larsen, S Griffin	J Pers Assess	1985	16367493	Yes
1672	1452	1452.0	40.73	40.7	Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms.	J A Beavo	Physiol Rev	1995	7480160	No
1673	1452	1452.0	0.0	0.0	Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues.	I E Bush	Biochem J	1952	14915960	Yes
1674	1452	1452.0	35.65	35.6	The hippo signaling pathway in development and cancer.	Duojia Pan	Dev Cell	2010	20951342	No
1675	1451	1451.0	39.32	39.3	Redox signaling: nitrosylation and related target interactions of nitric oxide.	J S Stamler	Cell	1994	7923362	No
1676	1451	1451.0	0.0	0.0	Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes.	P C Nowell	Cancer Res	1960	14427849	Yes
1677	1451	1451.0	34.78	34.8	Perceptions of epigenetics.	Adrian Bird	Nature	2007	17522671	Yes
1678	1450	1450.0	46.56	46.6	Constructions of masculinity and their influence on men's well-being: a theory of gender and health.	W H Courtenay	Soc Sci Med	2000	10741575	No
1679	1450	1450.0	31.55	31.6	Oxidative stress shortens telomeres.	Thomas von Zglinicki	Trends Biochem Sci	2002	12114022	Yes
1680	1450	1450.0	35.83	35.8	Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study).	K M Fox	Lancet	2003	13678872	Yes
1681	4347	1449.0	0.0	0.0	Hydroperoxide metabolism in mammalian organs.	B Chance, H Sies, A Boveris	Physiol Rev	1979	37532	Yes
1682	1449	1449.0	0.0	0.0	Ionic blockage of sodium channels in nerve.	A M Woodhull	J Gen Physiol	1973	4541078	Yes
1683	1449	1449.0	0.0	0.0	Starch gel electrophoresis in a discontinous system of buffers.	M D Poulik	Nature	1957	13493570	Yes
1684	1448	1448.0	0.0	0.0	The organization of proteins in the human red blood cell membrane. A review.	T L Steck	J Cell Biol	1974	4600883	No
1685	1448	1448.0	0.0	0.0	Defective repair replication of DNA in xeroderma pigmentosum.	J E Cleaver	Nature	1968	5655953	Yes
1686	1448	1448.0	34.81	34.8	A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin.	D A Gewirtz	Biochem Pharmacol	1999	10075079	No
1687	1448	1448.0	28.97	29.0	Intrinsically unstructured proteins.	Peter Tompa	Trends Biochem Sci	2002	12368089	No
1688	2895	1447.5	0.0	0.0	Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses.	D H Clarke, J Casals	Am J Trop Med Hyg	1958	13571577	Yes
1689	8685	1447.5	288.69	48.1	Cancer statistics, 2009.	Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J Thun	CA Cancer J Clin	2009	19474385	Yes
1690	1447	1447.0	0.0	0.0	The mechanism of muscular contraction.	H E Huxley	Science	1969	4181952	No
1691	4341	1447.0	118.2	39.4	A neural substrate of prediction and reward.	W Schultz, P Dayan, P R Montague	Science	1997	9054347	No
1692	1447	1447.0	31.3	31.3	Neurotrophins and their receptors: a convergence point for many signalling pathways.	Moses V Chao	Nat Rev Neurosci	2003	12671646	No
1693	7235	1447.0	0.0	0.0	Studies Of Illness In The Aged. The Index Of Adl: A Standardized Measure Of Biological And Psychosocial Function.	S Katz, A B Ford, R W Moskowitz, B A Jackson, M W Jaffe	JAMA	1963	14044222	Yes
1694	1447	1447.0	0.0	0.0	The free amino groups of insulin.	F Sanger	Biochem J	1945	16747948	Yes
1695	2894	1447.0	95.38	47.7	Alzheimer's disease.	Henry W Querfurth, Frank M LaFerla	N Engl J Med	2010	20107219	No
1696	1445	1445.0	31.62	31.6	Drug discovery: a historical perspective.	J Drews	Science	2000	10720314	No
1697	2889	1444.5	0.0	0.0	Diabetes and cardiovascular disease. The Framingham study.	W B Kannel, D L McGee	JAMA	1979	430798	Yes
1698	5778	1444.5	0.0	0.0	The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes.	L A Sternberger, P H Hardy, J J Cuculis, H G Meyer	J Histochem Cytochem	1970	4192899	Yes
1699	1444	1444.0	48.48	48.5	Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC.	G A McPherson	J Pharmacol Methods	1985	3840547	Yes
1700	2888	1444.0	83.39	41.7	Diarrheagenic Escherichia coli.	J P Nataro, J B Kaper	Clin Microbiol Rev	1998	9457432	No
1701	1444	1444.0	32.03	32.0	From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.	W A Catterall	Neuron	2000	10798388	No
1702	2888	1444.0	72.39	36.2	Shared principles in NF-kappaB signaling.	Matthew S Hayden, Sankar Ghosh	Cell	2008	18267068	No
1703	2887	1443.5	66.88	33.4	Complex networks orchestrate epithelial-mesenchymal transitions.	Jean Paul Thiery, Jonathan P Sleeman	Nat Rev Mol Cell Biol	2006	16493418	No
1704	2887	1443.5	98.53	49.3	Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference.	Stephen M Smith, Thomas E Nichols	Neuroimage	2009	18501637	Yes
1705	1442	1442.0	0.0	0.0	Impulses and Physiological States in Theoretical Models of Nerve Membrane.	R Fitzhugh	Biophys J	1961	19431309	Yes
1706	2883	1441.5	79.97	40.0	A rapid boiling method for the preparation of bacterial plasmids.	D S Holmes, M Quigley	Anal Biochem	1981	6269464	Yes
1707	2883	1441.5	76.67	38.3	The expanding universe of T-cell subsets: Th1, Th2 and more.	T R Mosmann, S Sad	Immunol Today	1996	8820272	No
1708	1441	1441.0	46.15	46.1	Evidence for a central component of post-injury pain hypersensitivity.	C J Woolf	Nature	1983	6656869	Yes
1709	1440	1440.0	28.97	29.0	Protein kinases--the major drug targets of the twenty-first century?	Philip Cohen	Nat Rev Drug Discov	2002	12120282	No
1710	2879	1439.5	105.73	52.9	Palladium-catalyzed ligand-directed C-H functionalization reactions.	Thomas W Lyons, Melanie S Sanford	Chem Rev	2010	20078038	No
1711	1439	1439.0	0.0	0.0	Superoxide dismutases.	I Fridovich	Annu Rev Biochem	1975	1094908	No
1712	1439	1439.0	42.85	42.9	Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications.	M D Maines	FASEB J	1988	3290025	No
1713	1439	1439.0	0.0	0.0	Nutrition needs of mammalian cells in tissue culture.	H Eagle	Science	1955	13255879	Yes
1714	2877	1438.5	0.0	0.0	3' non-coding region sequences in eukaryotic messenger RNA.	N J Proudfoot, G G Brownlee	Nature	1976	822353	Yes
1715	2877	1438.5	97.39	48.7	Molecular mechanisms and clinical applications of angiogenesis.	Peter Carmeliet, Rakesh K Jain	Nature	2011	21593862	No
1716	1438	1438.0	0.0	0.0	Stimulated acoustic emissions from within the human auditory system.	D T Kemp	J Acoust Soc Am	1978	744838	Yes
1717	1438	1438.0	41.99	42.0	Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat.	P A Bradford	Clin Microbiol Rev	2001	11585791	No
1718	1438	1438.0	37.67	37.7	Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia.	Shitij Kapur	Am J Psychiatry	2003	12505794	No
1719	2872	1436.0	0.0	0.0	Assay of proteins in the presence of interfering materials.	A Bensadoun, D Weinstein	Anal Biochem	1976	1259145	Yes
1720	2872	1436.0	0.0	0.0	Mutants of Escherichia coli requiring methionine or vitamin B12.	B D Davis, E S Mingioli	J Bacteriol	1950	15436457	Yes
1721	2870	1435.0	59.59	29.8	NF-kappaB regulation in the immune system.	Qiutang Li, Inder M Verma	Nat Rev Immunol	2002	12360211	No
1722	1434	1434.0	37.63	37.6	Capacitative calcium entry revisited.	J W Putney	Cell Calcium	1990	1965707	No
1723	4302	1434.0	120.51	40.2	Dating of the human-ape splitting by a molecular clock of mitochondrial DNA.	M Hasegawa, H Kishino, T Yano	J Mol Evol	1985	3934395	Yes
1724	1434	1434.0	0.0	0.0	Electron Microscope Studies On The Structure Of Natural And Synthetic Protein Filaments From Striated Muscle.	H E Huxley	J Mol Biol	1963	14064165	Yes
1725	2867	1433.5	110.21	55.1	Shifting the genomic gold standard for the prokaryotic species definition.	Michael Richter, Ramon Rosselló-Móra	Proc Natl Acad Sci U S A	2009	19855009	Yes
1726	14333	1433.3	357.29	35.7	Multilineage potential of adult human mesenchymal stem cells.	M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R Marshak	Science	1999	10102814	Yes
1727	1433	1433.0	34.13	34.1	Binary Agrobacterium vectors for plant transformation.	M Bevan	Nucleic Acids Res	1984	6095209	Yes
1728	2865	1432.5	74.8	37.4	Empirical threshold values for quantitative trait mapping.	G A Churchill, R W Doerge	Genetics	1994	7851788	Yes
1729	1432	1432.0	37.18	37.2	Type I diabetes mellitus. A chronic autoimmune disease.	G S Eisenbarth	N Engl J Med	1986	3517648	No
1730	1431	1431.0	28.9	28.9	Protein degradation and protection against misfolded or damaged proteins.	Alfred L Goldberg	Nature	2003	14685250	No
1731	5723	1430.8	234.19	58.5	16S ribosomal DNA amplification for phylogenetic study.	W G Weisburg, S M Barns, D A Pelletier, D J Lane	J Bacteriol	1991	1987160	Yes
1732	2859	1429.5	111.84	55.9	The mini-mental state examination: a comprehensive review.	T N Tombaugh, N J McIntyre	J Am Geriatr Soc	1992	1512391	No
1733	12853	1428.1	402.27	44.7	The 1982 revised criteria for the classification of systemic lupus erythematosus.	E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J Winchester	Arthritis Rheum	1982	7138600	Yes
1734	1428	1428.0	0.0	0.0	Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate.	J W Olney	Science	1969	5778021	Yes
1735	2856	1428.0	55.7	27.9	The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.	Michael H Glickman, Aaron Ciechanover	Physiol Rev	2002	11917093	No
1736	2855	1427.5	61.02	30.5	Toll-like receptor control of the adaptive immune responses.	Akiko Iwasaki, Ruslan Medzhitov	Nat Immunol	2004	15454922	No
1737	4279	1426.3	111.96	37.3	The rapid generation of mutation data matrices from protein sequences.	D T Jones, W R Taylor, J M Thornton	Comput Appl Biosci	1992	1633570	Yes
1738	1426	1426.0	32.52	32.5	An approximately unbiased test of phylogenetic tree selection.	Hidetoshi Shimodaira	Syst Biol	2002	12079646	Yes
1739	1425	1425.0	25.86	25.9	Histone acetylation and transcriptional regulatory mechanisms.	K Struhl	Genes Dev	1998	9499396	No
1740	2850	1425.0	57.13	28.6	Missing pieces in the NF-kappaB puzzle.	Sankar Ghosh, Michael Karin	Cell	2002	11983155	No
1741	1424	1424.0	0.0	0.0	A clinical method for assessing the ventilatory response to carbon dioxide.	D J Read	Australas Ann Med	1967	6032026	Yes
1742	1424	1424.0	45.54	45.5	Polycystic ovary syndrome.	S Franks	N Engl J Med	1995	7651477	No
1743	2847	1423.5	105.38	52.7	The transtheoretical model of health behavior change.	J O Prochaska, W F Velicer	Am J Health Promot	1997	10170434	No
1744	5693	1423.2	118.72	29.7	A comparison of normalization methods for high density oligonucleotide array data based on variance and bias.	B M Bolstad, R A Irizarry, M Astrand, T P Speed	Bioinformatics	2003	12538238	Yes
1745	1423	1423.0	29.45	29.4	Immunosuppressive networks in the tumour environment and their therapeutic relevance.	Weiping Zou	Nat Rev Cancer	2005	15776005	No
1746	1422	1422.0	0.0	0.0	Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis.	M P Blaustein	Am J Physiol	1977	324293	No
1747	1422	1422.0	32.81	32.8	The cadherins: cell-cell adhesion molecules controlling animal morphogenesis.	M Takeichi	Development	1988	3048970	No
1748	1422	1422.0	0.0	0.0	A modified ninhydrin colorimetric analysis for amino acids.	H Rosen	Arch Biochem Biophys	1957	13412116	Yes
1749	1421	1421.0	33.65	33.6	Developmental cell death: morphological diversity and multiple mechanisms.	P G Clarke	Anat Embryol (Berl)	1990	2186664	No
1750	1420	1420.0	33.88	33.9	Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis.	S C Manolagas	Endocr Rev	2000	10782361	No
1751	2839	1419.5	55.58	27.8	Cellular motility driven by assembly and disassembly of actin filaments.	Thomas D Pollard, Gary G Borisy	Cell	2003	12600310	No
1752	1419	1419.0	51.44	51.4	Dual-task interference in simple tasks: data and theory.	H Pashler	Psychol Bull	1994	7972591	No
1753	1419	1419.0	35.4	35.4	In vivo near-infrared fluorescence imaging.	John V Frangioni	Curr Opin Chem Biol	2003	14580568	No
1754	2836	1418.0	82.94	41.5	Dali server: conservation mapping in 3D.	Liisa Holm, Päivi Rosenström	Nucleic Acids Res	2010	20457744	Yes
1755	2834	1417.0	54.15	27.1	Mutations affecting segment number and polarity in Drosophila.	C Nüsslein-Volhard, E Wieschaus	Nature	1980	6776413	Yes
1756	2834	1417.0	72.32	36.2	Adipose tissue as an endocrine organ.	Erin E Kershaw, Jeffrey S Flier	J Clin Endocrinol Metab	2004	15181022	No
1757	1415	1415.0	33.52	33.5	Pathogenesis of group A streptococcal infections.	M W Cunningham	Clin Microbiol Rev	2000	10885988	No
1758	2829	1414.5	67.94	34.0	The human plasma proteome: history, character, and diagnostic prospects.	N Leigh Anderson, Norman G Anderson	Mol Cell Proteomics	2002	12488461	No
1759	4243	1414.3	106.08	35.4	Two-photon laser scanning fluorescence microscopy.	W Denk, J H Strickler, W W Webb	Science	1990	2321027	Yes
1760	1414	1414.0	35.23	35.2	General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.	R A Houghten	Proc Natl Acad Sci U S A	1985	2410914	Yes
1761	1414	1414.0	0.0	0.0	The Gingival Index, the Plaque Index and the Retention Index Systems.	H Löe	J Periodontol	1967	5237684	Yes
1762	1414	1414.0	33.55	33.5	PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms.	Michael F. Thomashow	Annu Rev Plant Physiol Plant Mol Biol	1999	15012220	Yes
1763	2828	1414.0	63.74	31.9	Raster3D Version 2.0. A program for photorealistic molecular graphics.	E A Merritt, M E Murphy	Acta Crystallogr D Biol Crystallogr	1994	15299354	Yes
1764	1414	1414.0	0.0	0.0	Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions.	W C Schneider	J Biol Chem	1948	18886166	Yes
1765	2827	1413.5	69.01	34.5	The incidence of congenital heart disease.	Julien I E Hoffman, Samuel Kaplan	J Am Coll Cardiol	2002	12084585	No
1766	1413	1413.0	0.0	0.0	Amino acid difference formula to help explain protein evolution.	R Grantham	Science	1974	4843792	Yes
1767	1413	1413.0	0.0	0.0	Modality and topographic properties of single neurons of cat's somatic sensory cortex.	V B Mountcastle	J Neurophysiol	1957	13439410	Yes
1768	2826	1413.0	0.0	0.0	Microdetermination of long-chain fatty acids in plasma and tissues.	V P Dole, H Meinertz	J Biol Chem	1960	13817286	Yes
1769	4239	1413.0	0.0	0.0	Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs.	C A Winter, E A Risley, G W Nuss	Proc Soc Exp Biol Med	1962	14001233	Yes
1770	2825	1412.5	75.29	37.6	Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation.	M A Nitsche, W Paulus	J Physiol	2000	10990547	Yes
1771	1412	1412.0	45.89	45.9	The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate.	G R Buettner	Arch Biochem Biophys	1993	8434935	No
1772	2823	1411.5	62.5	31.2	Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions.	E Krissinel, K Henrick	Acta Crystallogr D Biol Crystallogr	2004	15572779	Yes
1773	1411	1411.0	34.0	34.0	PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.	B M Spiegelman	Diabetes	1998	9568680	No
1774	1411	1411.0	27.25	27.2	Aggresomes, inclusion bodies and protein aggregation.	R R Kopito	Trends Cell Biol	2000	11121744	No
1775	2822	1411.0	59.86	29.9	The Bcl2 family: regulators of the cellular life-or-death switch.	Suzanne Cory, Jerry M Adams	Nat Rev Cancer	2002	12209154	No
1776	1411	1411.0	36.74	36.7	The biology of incretin hormones.	Daniel J Drucker	Cell Metab	2006	16517403	No
1777	2819	1409.5	61.71	30.9	The Ki-67 protein: from the known and the unknown.	T Scholzen, J Gerdes	J Cell Physiol	2000	10653597	No
1778	1409	1409.0	30.18	30.2	Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy.	R K Jain	Nat Med	2001	11533692	No
1779	1407	1407.0	0.0	0.0	The Function Of The Vertebral Veins And Their Role In The Spread Of Metastases.	O V Batson	Ann Surg	1940	17857618	Yes
1780	2814	1407.0	81.71	40.9	Multiple sclerosis.	Alastair Compston, Alasdair Coles	Lancet	2008	18970977	Yes
1781	2813	1406.5	59.17	29.6	Chemokines: a new classification system and their role in immunity.	A Zlotnik, O Yoshie	Immunity	2000	10714678	No
1782	2811	1405.5	84.33	42.2	The precuneus: a review of its functional anatomy and behavioural correlates.	Andrea E Cavanna, Michael R Trimble	Brain	2006	16399806	No
1783	1405	1405.0	77.51	77.5	Subjective well-being.	E Diener	Psychol Bull	1984	6399758	No
1784	1405	1405.0	28.63	28.6	Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing.	D I Svergun	Biophys J	1999	10354416	Yes
1785	1405	1405.0	32.79	32.8	Mechanisms of bone metastasis.	G David Roodman	N Engl J Med	2004	15084698	No
1786	1405	1405.0	30.11	30.1	Regulatory T cells, tumour immunity and immunotherapy.	Weiping Zou	Nat Rev Immunol	2006	16557261	No
1787	2806	1403.0	66.56	33.3	The MAPK signaling cascade.	R Seger, E G Krebs	FASEB J	1995	7601337	No
1788	2804	1402.0	65.92	33.0	A novel multigene family may encode odorant receptors: a molecular basis for odor recognition.	L Buck, R Axel	Cell	1991	1840504	Yes
1789	1401	1401.0	58.99	59.0	Responses to depression and their effects on the duration of depressive episodes.	S Nolen-Hoeksema	J Abnorm Psychol	1991	1757671	No
1790	5602	1400.5	143.74	35.9	Improved optimization for the robust and accurate linear registration and motion correction of brain images.	Mark Jenkinson, Peter Bannister, Michael Brady, Stephen Smith	Neuroimage	2002	12377157	Yes
1791	1400	1400.0	36.08	36.1	Insulin and insulin-like growth factor signalling in neoplasia.	Michael Pollak	Nat Rev Cancer	2008	19029956	No
1792	1400	1400.0	51.54	51.5	Cognitive reserve.	Yaakov Stern	Neuropsychologia	2009	19467352	No
1793	1399	1399.0	51.89	51.9	The case-crossover design: a method for studying transient effects on the risk of acute events.	M Maclure	Am J Epidemiol	1991	1985444	Yes
1794	1399	1399.0	61.45	61.5	Antibiotics in the aquatic environment--a review--part I.	Klaus Kümmerer	Chemosphere	2009	19185900	No
1795	1397	1397.0	44.01	44.0	Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance.	L Bravo	Nutr Rev	1998	9838798	No
1796	2792	1396.0	83.77	41.9	An information-maximization approach to blind separation and blind deconvolution.	A J Bell, T J Sejnowski	Neural Comput	1995	7584893	Yes
1797	2792	1396.0	0.0	0.0	Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.	H J Bloom, W W Richardson	Br J Cancer	1957	13499785	Yes
1798	1396	1396.0	34.51	34.5	Neurovascular regulation in the normal brain and in Alzheimer's disease.	Costantino Iadecola	Nat Rev Neurosci	2004	15100718	No
1799	4187	1395.7	92.86	31.0	NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.	S Ghosh, M J May, E B Kopp	Annu Rev Immunol	1998	9597130	No
1800	1395	1395.0	65.27	65.3	The structure and properties of the sense of coherence scale.	A Antonovsky	Soc Sci Med	1993	8480217	Yes
1801	2790	1395.0	65.09	32.5	How matrix metalloproteinases regulate cell behavior.	M D Sternlicht, Z Werb	Annu Rev Cell Dev Biol	2001	11687497	No
1802	1395	1395.0	0.0	0.0	Linked Functions And Reciprocal Effects In Hemoglobin: A Second Look.	J Wyman	Adv Protein Chem	1964	14268785	No
1803	2788	1394.0	0.0	0.0	Empirical predictions of protein conformation.	P Y Chou, G D Fasman	Annu Rev Biochem	1978	354496	No
1804	1394	1394.0	55.77	55.8	Large-scale brain networks and psychopathology: a unifying triple network model.	Vinod Menon	Trends Cogn Sci	2011	21908230	No
1805	1394	1394.0	56.79	56.8	Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement.	Virginia A Moyer	Ann Intern Med	2012	22801674	No
1806	1393	1393.0	0.0	0.0	Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.	K S McCully	Am J Pathol	1969	5792556	Yes
1807	5572	1393.0	126.7	31.7	MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform.	Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi Miyata	Nucleic Acids Res	2002	12136088	Yes
1808	6961	1392.2	147.4	29.5	Prospective identification of tumorigenic breast cancer cells.	Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F Clarke	Proc Natl Acad Sci U S A	2003	12629218	Yes
1809	2783	1391.5	85.39	42.7	The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.	J D Hayes, D J Pulford	Crit Rev Biochem Mol Biol	1995	8770536	No
1810	2782	1391.0	85.91	43.0	Intracellular pH.	A Roos, W F Boron	Physiol Rev	1981	7012859	No
1811	5564	1391.0	164.92	41.2	Functional connectivity in the motor cortex of resting human brain using echo-planar MRI.	B Biswal, F Z Yetkin, V M Haughton, J S Hyde	Magn Reson Med	1995	8524021	Yes
1812	1391	1391.0	50.17	50.2	Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances.	Joseph J Volpe	Lancet Neurol	2009	19081519	No
1813	1391	1391.0	72.72	72.7	Statistics corner: A guide to appropriate use of correlation coefficient in medical research.	M M Mukaka	Malawi Med J	2012	23638278	Yes
1814	5561	1390.2	242.86	60.7	An inventory for measuring clinical anxiety: psychometric properties.	A T Beck, N Epstein, G Brown, R A Steer	J Consult Clin Psychol	1988	3204199	Yes
1815	2780	1390.0	72.96	36.5	Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators.	I Issemann, S Green	Nature	1990	2129546	Yes
1816	1390	1390.0	0.0	0.0	R factor transfer in Rhizobium leguminosarum.	J E Beringer	J Gen Microbiol	1974	4612098	Yes
1817	1390	1390.0	39.25	39.2	Pathogen recognition and inflammatory signaling in innate immune defenses.	Trine H Mogensen	Clin Microbiol Rev	2009	19366914	No
1818	1389	1389.0	50.96	51.0	Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders.	Berislav V Zlokovic	Nat Rev Neurosci	2011	22048062	No
1819	5552	1388.0	0.0	0.0	A rating scale for mania: reliability, validity and sensitivity.	R C Young, J T Biggs, V E Ziegler, D A Meyer	Br J Psychiatry	1978	728692	Yes
1820	2774	1387.0	0.0	0.0	A method of trace iodination of proteins for immunologic studies.	P J McConahey, F J Dixon	Int Arch Allergy Appl Immunol	1966	4160044	Yes
1821	2774	1387.0	85.73	42.9	Unified approach for molecular dynamics and density-functional theory.	Car, Parrinello	Phys Rev Lett	1985	10032153	Yes
1822	1387	1387.0	36.3	36.3	Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology.	B Winkel-Shirley	Plant Physiol	2001	11402179	No
1823	2774	1387.0	0.0	0.0	Brain stem reticular formation and activation of the EEG.	G Moruzzi, H W Magoun	Electroencephalogr Clin Neurophysiol	1949	18421835	Yes
1824	6934	1386.8	150.32	30.1	Site-directed mutagenesis by overlap extension using the polymerase chain reaction.	S N Ho, H D Hunt, R M Horton, J K Pullen, L R Pease	Gene	1989	2744487	Yes
1825	1386	1386.0	34.59	34.6	The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting.	H Maeda	Adv Enzyme Regul	2001	11384745	No
1826	2770	1385.0	71.82	35.9	A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.	J Messing, J Vieira	Gene	1982	6295880	Yes
1827	1384	1384.0	46.61	46.6	Validation of a decisional conflict scale.	A M O'Connor	Med Decis Making	1995	7898294	Yes
1828	1383	1383.0	0.0	0.0	Statistical analysis of enzyme kinetic data.	W W Cleland	Methods Enzymol	1979	502857	Yes
1829	1382	1382.0	32.66	32.7	Speculations on the functions of the major heat shock and glucose-regulated proteins.	H R Pelham	Cell	1986	2944601	Yes
1830	2764	1382.0	0.0	0.0	A protein sequenator.	P Edman, G Begg	Eur J Biochem	1967	6059350	Yes
1831	1381	1381.0	0.0	0.0	The genetical evolution of social behaviour. II.	W D Hamilton	J Theor Biol	1964	5875340	Yes
1832	1381	1381.0	33.03	33.0	Functions of ceramide in coordinating cellular responses to stress.	Y A Hannun	Science	1996	8943189	No
1833	4141	1380.3	120.72	40.2	The fusiform face area: a module in human extrastriate cortex specialized for face perception.	N Kanwisher, J McDermott, M M Chun	J Neurosci	1997	9151747	Yes
1834	1380	1380.0	0.0	0.0	Selection of successive tumour lines for metastasis.	I J Fidler	Nat New Biol	1973	4512654	Yes
1835	1380	1380.0	0.0	0.0	The measurement of psychological androgyny.	S L Bem	J Consult Clin Psychol	1974	4823550	Yes
1836	2760	1380.0	62.46	31.2	An essential role for NF-kappaB in preventing TNF-alpha-induced cell death.	A A Beg, D Baltimore	Science	1996	8864118	Yes
1837	1380	1380.0	0.0	0.0	Evidence For The Existence Of Monoamine Neurons In The Central Nervous System. Iv. Distribution Of Monoamine Nerve Terminals In The Central Nervous System.	K Fuxe	Acta Physiol Scand Suppl	1965	14319769	Yes
1838	1380	1380.0	51.68	51.7	Falls in older people: epidemiology, risk factors and strategies for prevention.	Laurence Z Rubenstein	Age Ageing	2006	16926202	No
1839	4139	1379.7	141.82	47.3	Vascular endothelial cells synthesize nitric oxide from L-arginine.	R M Palmer, D S Ashton, S Moncada	Nature	1988	3131684	Yes
1840	1379	1379.0	0.0	0.0	Human cardiovascular adjustments to exercise and thermal stress.	L B Rowell	Physiol Rev	1974	4587247	No
1841	1379	1379.0	36.61	36.6	Aspergillus fumigatus and aspergillosis.	J P Latgé	Clin Microbiol Rev	1999	10194462	No
1842	2757	1378.5	0.0	0.0	Mutations of Bacteria from Virus Sensitivity to Virus Resistance.	S E Luria, M Delbrück	Genetics	1943	17247100	Yes
1843	5513	1378.2	126.36	31.6	Probability-based protein identification by searching sequence databases using mass spectrometry data.	D N Perkins, D J Pappin, D M Creasy, J S Cottrell	Electrophoresis	1999	10612281	Yes
1844	1378	1378.0	31.08	31.1	Protein misfolding, evolution and disease.	C M Dobson	Trends Biochem Sci	1999	10470028	No
1845	1377	1377.0	0.0	0.0	Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat.	C A Barnes	J Comp Physiol Psychol	1979	221551	Yes
1846	1377	1377.0	72.69	72.7	Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control.	F E Zajac	Crit Rev Biomed Eng	1989	2676342	No
1847	2753	1376.5	91.88	45.9	The efficiency of systematic sampling in stereology and its prediction.	H J Gundersen, E B Jensen	J Microsc	1987	3430576	Yes
1848	1376	1376.0	27.29	27.3	Vienna RNA secondary structure server.	Ivo L Hofacker	Nucleic Acids Res	2003	12824340	Yes
1849	2751	1375.5	88.7	44.4	Functional architecture of basal ganglia circuits: neural substrates of parallel processing.	G E Alexander, M D Crutcher	Trends Neurosci	1990	1695401	No
1850	1375	1375.0	33.19	33.2	Far-field optical nanoscopy.	Stefan W Hell	Science	2007	17525330	No
1851	1374	1374.0	0.0	0.0	An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals.	O Smithies	Biochem J	1959	13638269	Yes
1852	1374	1374.0	40.94	40.9	n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases.	Philip C Calder	Am J Clin Nutr	2006	16841861	No
1853	2746	1373.0	0.0	0.0	A scaled version of the General Health Questionnaire.	D P Goldberg, V F Hillier	Psychol Med	1979	424481	Yes
1854	2746	1373.0	70.37	35.2	CLUSTAL: a package for performing multiple sequence alignment on a microcomputer.	D G Higgins, P M Sharp	Gene	1988	3243435	Yes
1855	2744	1372.0	100.33	50.2	Biology of disease: free radicals and tissue injury.	B A Freeman, J D Crapo	Lab Invest	1982	6290784	No
1856	1372	1372.0	29.45	29.4	Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.	S S Ferguson	Pharmacol Rev	2001	11171937	No
1857	4115	1371.7	108.73	36.2	Optimization by simulated annealing.	S Kirkpatrick, C D Gelatt, M P Vecchi	Science	1983	17813860	Yes
1858	2743	1371.5	0.0	0.0	Prediction of protein conformation.	P Y Chou, G D Fasman	Biochemistry	1974	4358940	Yes
1859	2743	1371.5	101.08	50.5	Neurocircuitry of addiction.	George F Koob, Nora D Volkow	Neuropsychopharmacology	2010	19710631	No
1860	1371	1371.0	39.59	39.6	Isolation and cultivation of Lyme disease spirochetes.	A G Barbour	Yale J Biol Med	1984	6393604	Yes
1861	1371	1371.0	26.47	26.5	Ubiquitin-dependent protein degradation.	M Hochstrasser	Annu Rev Genet	1996	8982460	No
1862	1371	1371.0	0.0	0.0	Effects of varying the vehicle for OsO4 in tissue fixation.	J B Caulfield	J Biophys Biochem Cytol	1957	13475399	Yes
1863	2741	1370.5	59.55	29.8	Development by self-digestion: molecular mechanisms and biological functions of autophagy.	Beth Levine, Daniel J Klionsky	Dev Cell	2004	15068787	No
1864	1370	1370.0	32.59	32.6	The molecular logic of endocannabinoid signalling.	Daniele Piomelli	Nat Rev Neurosci	2003	14595399	No
1865	2739	1369.5	70.2	35.1	Steatohepatitis: a tale of two "hits"?	C P Day, O F James	Gastroenterology	1998	9547102	No
1866	2739	1369.5	67.51	33.8	Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.	F Q Schafer, G R Buettner	Free Radic Biol Med	2001	11368918	No
1867	2736	1368.0	0.0	0.0	Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.	A J Berk, P A Sharp	Cell	1977	922889	Yes
1868	1368	1368.0	33.33	33.3	The basic science of gene therapy.	R C Mulligan	Science	1993	8493530	No
1869	1368	1368.0	30.11	30.1	Neurotrophins as synaptic modulators.	M M Poo	Nat Rev Neurosci	2001	11253356	No
1870	1368	1368.0	43.52	43.5	Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements.	James J P Stewart	J Mol Model	2007	17828561	Yes
1871	2735	1367.5	59.62	29.8	Coordination of circadian timing in mammals.	Steven M Reppert, David R Weaver	Nature	2002	12198538	No
1872	2735	1367.5	0.0	0.0	The effect of sodium ions on the electrical activity of giant axon of the squid.	A L Hodgkin, B Katz	J Physiol	1949	18128147	Yes
1873	1366	1366.0	31.77	31.8	Protein kinase C: structure, function, and regulation.	A C Newton	J Biol Chem	1995	7499357	No
1874	2732	1366.0	91.5	45.8	Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics.	G R Gibson, M B Roberfroid	J Nutr	1995	7782892	No
1875	2730	1365.0	63.18	31.6	Microtubules as a target for anticancer drugs.	Mary Ann Jordan, Leslie Wilson	Nat Rev Cancer	2004	15057285	No
1876	1365	1365.0	37.9	37.9	External validity of randomised controlled trials: "to whom do the results of this trial apply?".	Peter M Rothwell	Lancet	2005	15639683	Yes
1877	1365	1365.0	0.0	0.0	Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples.	P F Scholander	J Biol Chem	1947	20281644	Yes
1878	2729	1364.5	62.21	31.1	Neurotrophins: roles in neuronal development and function.	E J Huang, L F Reichardt	Annu Rev Neurosci	2001	11520916	No
1879	1364	1364.0	0.0	0.0	Microbial ecology of the gastrointestinal tract.	D C Savage	Annu Rev Microbiol	1977	334036	No
1880	1364	1364.0	92.31	92.3	The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system.	F C Ewald	Clin Orthop Relat Res	1989	2805502	Yes
1881	1364	1364.0	26.46	26.5	NK cell receptors.	L L Lanier	Annu Rev Immunol	1998	9597134	No
1882	2727	1363.5	70.32	35.2	Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins.	D Marion, K Wüthrich	Biochem Biophys Res Commun	1983	6307308	Yes
1883	2726	1363.0	101.58	50.8	Pain assessment: global use of the Brief Pain Inventory.	C S Cleeland, K M Ryan	Ann Acad Med Singap	1994	8080219	No
1884	1362	1362.0	47.83	47.8	Multiple calcium channels and neuronal function.	R J Miller	Science	1987	2432656	No
1885	2724	1362.0	53.25	26.6	T-cell antigen receptor genes and T-cell recognition.	M M Davis, P J Bjorkman	Nature	1988	3043226	No
1886	1362	1362.0	35.45	35.5	Stress and hippocampal plasticity.	B S McEwen	Annu Rev Neurosci	1999	10202533	No
1887	1362	1362.0	35.17	35.2	Myeloperoxidase: friend and foe.	Seymour J Klebanoff	J Leukoc Biol	2005	15689384	No
1888	2722	1361.0	82.08	41.0	Glycine potentiates the NMDA response in cultured mouse brain neurons.	J W Johnson, P Ascher	Nature	1987	2433595	Yes
1889	1361	1361.0	36.88	36.9	Cell and environment interactions in tumor microregions: the multicell spheroid model.	R M Sutherland	Science	1988	2451290	Yes
1890	1360	1360.0	56.52	56.5	A structured interview guide for the Hamilton Depression Rating Scale.	J B Williams	Arch Gen Psychiatry	1988	3395203	Yes
1891	2720	1360.0	57.26	28.6	Fitting a mixture model by expectation maximization to discover motifs in biopolymers.	T L Bailey, C Elkan	Proc Int Conf Intell Syst Mol Biol	1994	7584402	Yes
1892	2720	1360.0	76.06	38.0	Transforming growth factor beta in tissue fibrosis.	W A Border, N A Noble	N Engl J Med	1994	7935686	No
1893	2720	1360.0	0.0	0.0	Evidence For The Existence Of Monoamine-Containing Neurons In The Central Nervous System. I. Demonstration Of Monoamines In The Cell Bodies Of Brain Stem Neurons.	A Dahlstroem, K Fuxe	Acta Physiol Scand Suppl	1964	14229500	Yes
1894	2719	1359.5	75.52	37.8	Early identification of refractory epilepsy.	P Kwan, M J Brodie	N Engl J Med	2000	10660394	Yes
1895	1359	1359.0	0.0	0.0	Codon--anticodon pairing: the wobble hypothesis.	F H Crick	J Mol Biol	1966	5969078	Yes
1896	1359	1359.0	32.02	32.0	The NCI60 human tumour cell line anticancer drug screen.	Robert H Shoemaker	Nat Rev Cancer	2006	16990858	No
1897	2717	1358.5	90.03	45.0	Unidentified curved bacilli on gastric epithelium in active chronic gastritis.	J R Warren, B Marshall	Lancet	1983	6134060	Yes
1898	1358	1358.0	38.7	38.7	A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology.	J Engel	Epilepsia	2001	11422340	Yes
1899	1358	1358.0	0.0	0.0	Note on the sampling error of the difference between correlated proportions or percentages.	Q McNEMAR	Psychometrika	1947	20254758	Yes
1900	1357	1357.0	34.86	34.9	Thioredoxin and glutaredoxin systems.	A Holmgren	J Biol Chem	1989	2668278	No
1901	1357	1357.0	30.56	30.6	Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles.	M Kozak	Microbiol Rev	1983	6343825	No
1902	1357	1357.0	43.43	43.4	The many roles for fluorine in medicinal chemistry.	William K Hagmann	J Med Chem	2008	18570365	Yes
1903	1356	1356.0	0.0	0.0	Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein.	T Spector	Anal Biochem	1978	655375	Yes
1904	1356	1356.0	0.0	0.0	Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion.	S S Lehrer	Biochemistry	1971	5119250	Yes
1905	1356	1356.0	57.22	57.2	Adverse health effects of high-effort/low-reward conditions.	J Siegrist	J Occup Health Psychol	1996	9547031	No
1906	2712	1356.0	81.38	40.7	Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research.	Sally S Dickerson, Margaret E Kemeny	Psychol Bull	2004	15122924	Yes
1907	2712	1356.0	90.07	45.0	Density functionals with broad applicability in chemistry.	Yan Zhao, Donald G Truhlar	Acc Chem Res	2008	18186612	Yes
1908	1356	1356.0	0.0	0.0	Potential, Impedance, And Rectification In Membranes.	D E Goldman	J Gen Physiol	1943	19873371	Yes
1909	2711	1355.5	0.0	0.0	Immunoassay of endogenous plasma insulin in man.	R S Yalow, S A Berson	J Clin Invest	1960	13846364	Yes
1910	2710	1355.0	67.56	33.8	Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.	E S Lander, D Botstein	Genetics	1989	2563713	Yes
1911	1355	1355.0	37.76	37.8	Task switching.	Stephen Monsell	Trends Cogn Sci	2003	12639695	Yes
1912	1355	1355.0	31.43	31.4	Cancer epigenomics: DNA methylomes and histone-modification maps.	Manel Esteller	Nat Rev Genet	2007	17339880	No
1913	1354	1354.0	40.48	40.5	The aging process.	D Harman	Proc Natl Acad Sci U S A	1981	6947277	Yes
1914	2708	1354.0	83.83	41.9	Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI.	P J Basser, C Pierpaoli	J Magn Reson B	1996	8661285	Yes
1915	1354	1354.0	39.87	39.9	Leishmaniasis: current situation and new perspectives.	P Desjeux	Comp Immunol Microbiol Infect Dis	2004	15225981	No
1916	1354	1354.0	28.56	28.6	RNA silencing in plants.	David Baulcombe	Nature	2004	15372043	No
1917	1354	1354.0	37.88	37.9	Integration, scaling, space-group assignment and post-refinement.	Wolfgang Kabsch	Acta Crystallogr D Biol Crystallogr	2010	20124693	Yes
1918	1354	1354.0	43.71	43.7	Systemic lupus erythematosus.	George C Tsokos	N Engl J Med	2011	22129255	No
1919	2707	1353.5	71.94	36.0	Malignant gliomas in adults.	Patrick Y Wen, Santosh Kesari	N Engl J Med	2008	18669428	No
1920	4060	1353.3	88.86	29.6	Toll-like receptors.	Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira	Annu Rev Immunol	2003	12524386	No
1921	4058	1352.7	0.0	0.0	Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins.	J Garnier, D J Osguthorpe, B Robson	J Mol Biol	1978	642007	Yes
1922	9468	1352.6	212.12	30.3	Embryonic stem cell lines derived from human blastocysts.	J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M Jones	Science	1998	9804556	Yes
1923	1352	1352.0	54.15	54.1	Cardiac valve surgery--the "French correction".	A Carpentier	J Thorac Cardiovasc Surg	1983	6887954	Yes
1924	5407	1351.8	0.0	0.0	Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.	D W Cleveland, S G Fischer, M W Kirschner, U K Laemmli	J Biol Chem	1977	320200	Yes
1925	2702	1351.0	85.78	42.9	Performing the exact test of Hardy-Weinberg proportion for multiple alleles.	S W Guo, E A Thompson	Biometrics	1992	1637966	Yes
1926	1351	1351.0	44.03	44.0	Glutathione metabolism and its selective modification.	A Meister	J Biol Chem	1988	3053703	No
1927	2701	1350.5	168.4	84.2	Rating systems in the evaluation of knee ligament injuries.	Y Tegner, J Lysholm	Clin Orthop Relat Res	1985	4028566	Yes
1928	1350	1350.0	45.26	45.3	Interleukin-1.	C A Dinarello	Rev Infect Dis	1984	6369481	No
1929	2700	1350.0	77.81	38.9	Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper.	B R Celli, W MacNee	Eur Respir J	2004	15219010	No
1930	1349	1349.0	31.48	31.5	Tumor metastasis: mechanistic insights and clinical challenges.	Patricia S Steeg	Nat Med	2006	16892035	No
1931	5393	1348.2	160.1	40.0	Comorbidity measures for use with administrative data.	A Elixhauser, C Steiner, D R Harris, R M Coffey	Med Care	1998	9431328	Yes
1932	4044	1348.0	90.46	30.2	Telomeres shorten during ageing of human fibroblasts.	C B Harley, A B Futcher, C W Greider	Nature	1990	2342578	Yes
1933	4043	1347.7	0.0	0.0	Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation.	D D Sabatini, K Bensch, R J Barrnett	J Cell Biol	1963	13975866	Yes
1934	2695	1347.5	0.0	0.0	The respiratory chain and oxidative phosphorylation.	B Chance, G R Williams	Adv Enzymol Relat Subj Biochem	1956	13313307	Yes
1935	1347	1347.0	34.76	34.8	An economic method for the fluorescent labeling of PCR fragments.	M Schuelke	Nat Biotechnol	2000	10657137	Yes
1936	2692	1346.0	0.0	0.0	The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat.	J O'Keefe, J Dostrovsky	Brain Res	1971	5124915	Yes
1937	2692	1346.0	63.5	31.8	Lipopolysaccharide endotoxins.	Christian R H Raetz, Chris Whitfield	Annu Rev Biochem	2002	12045108	No
1938	1346	1346.0	0.0	0.0	Cerebral vascular accidents in patients over the age of 60. II. Prognosis.	J Rankin	Scott Med J	1957	13432835	Yes
1939	1345	1345.0	44.04	44.0	Efficient analysis of experimental observations.	W J Dixon	Annu Rev Pharmacol Toxicol	1980	7387124	Yes
1940	1345	1345.0	32.01	32.0	Ordered porous materials for emerging applications.	Mark E Davis	Nature	2002	12075343	No
1941	2688	1344.0	55.68	27.8	Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.	P J Southern, P Berg	J Mol Appl Genet	1982	6286831	Yes
1942	2686	1343.0	0.0	0.0	Further improvements in the plaque technique for detecting single antibody-forming cells.	A J Cunningham, A Szenberg	Immunology	1968	5653817	Yes
1943	2686	1343.0	108.41	54.2	Assessment of eating disorders: interview or self-report questionnaire?	C G Fairburn, S J Beglin	Int J Eat Disord	1994	7866415	Yes
1944	1343	1343.0	0.0	0.0	A modified procedure for lead staining of thin sections.	G Millonig	J Biophys Biochem Cytol	1961	14474176	Yes
1945	1342	1342.0	0.0	0.0	Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.	J R David	Proc Natl Acad Sci U S A	1966	5229858	Yes
1946	1342	1342.0	0.0	0.0	A simple ultraviolet spectrophotometric method for the determination of protein.	W J Waddell	J Lab Clin Med	1956	13346201	Yes
1947	1341	1341.0	0.0	0.0	Blood gas calculator.	J W Severinghaus	J Appl Physiol	1966	5912737	Yes
1948	1341	1341.0	39.6	39.6	Glycobiology: Toward Understanding the Function of Sugars.	Raymond A. Dwek	Chem Rev	1996	11848770	Yes
1949	2682	1341.0	83.82	41.9	Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being.	James J Gross, Oliver P John	J Pers Soc Psychol	2003	12916575	Yes
1950	1341	1341.0	34.14	34.1	Five rules for the evolution of cooperation.	Martin A Nowak	Science	2006	17158317	No
1951	1341	1341.0	42.51	42.5	Surface plasmon resonance sensors for detection of chemical and biological species.	Jirí Homola	Chem Rev	2008	18229953	No
1952	2681	1340.5	101.6	50.8	The need to belong: desire for interpersonal attachments as a fundamental human motivation.	R F Baumeister, M R Leary	Psychol Bull	1995	7777651	No
1953	1340	1340.0	33.16	33.2	Neuronal synchrony: a versatile code for the definition of relations?	W Singer	Neuron	1999	10677026	No
1954	2679	1339.5	53.91	27.0	The evolutionary fate and consequences of duplicate genes.	M Lynch, J S Conery	Science	2000	11073452	No
1955	1339	1339.0	44.3	44.3	Social relationships and health.	Sheldon Cohen	Am Psychol	2004	15554821	No
1956	1339	1339.0	36.4	36.4	Use and misuse of the receiver operating characteristic curve in risk prediction.	Nancy R Cook	Circulation	2007	17309939	Yes
1957	2677	1338.5	66.15	33.1	Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress.	H Cai, D G Harrison	Circ Res	2000	11073878	No
1958	2677	1338.5	72.58	36.3	Obesity.	David W Haslam, W Philip T James	Lancet	2005	16198769	No
1959	4013	1337.7	96.17	32.1	Click Chemistry: Diverse Chemical Function from a Few Good Reactions.	Hartmuth C. Kolb, M. G. Finn, K. Barry Sharpless	Angew Chem Int Ed Engl	2001	11433435	Yes
1960	2673	1336.5	0.0	0.0	Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes.	E Engvall, P Perlmann	J Immunol	1972	4113792	Yes
1961	2672	1336.0	0.0	0.0	Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation.	R L Heath, L Packer	Arch Biochem Biophys	1968	5655425	Yes
1962	1336	1336.0	63.98	64.0	The emerging role of lncRNAs in cancer.	Maite Huarte	Nat Med	2015	26540387	No
1963	2670	1335.0	62.2	31.1	NF-kappaB: a key role in inflammatory diseases.	P P Tak, G S Firestein	J Clin Invest	2001	11134171	No
1964	2670	1335.0	62.31	31.2	Cancer metastasis: building a framework.	Gaorav P Gupta, Joan Massagué	Cell	2006	17110329	No
1965	1335	1335.0	35.09	35.1	The failing heart--an engine out of fuel.	Stefan Neubauer	N Engl J Med	2007	17360992	No
1966	5339	1334.8	163.97	41.0	The validity of the Hospital Anxiety and Depression Scale. An updated literature review.	Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag Neckelmann	J Psychosom Res	2002	11832252	No
1967	2669	1334.5	0.0	0.0	Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease.	G J Miller, N E Miller	Lancet	1975	46338	Yes
1968	2668	1334.0	0.0	0.0	Synchronization of Plasmodium falciparum erythrocytic stages in culture.	C Lambros, J P Vanderberg	J Parasitol	1979	383936	Yes
1969	1334	1334.0	48.38	48.4	Colorimetric determination of phospholipids with ammonium ferrothiocyanate.	J C Stewart	Anal Biochem	1980	6892980	Yes
1970	2668	1334.0	63.08	31.5	NF-kappa B: ten years after.	P A Baeuerle, D Baltimore	Cell	1996	8858144	No
1971	2668	1334.0	78.18	39.1	Mortality by cause for eight regions of the world: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9142060	Yes
1972	1333	1333.0	32.76	32.8	Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule.	G von Heijne	J Mol Biol	1992	1593632	Yes
1973	1333	1333.0	43.63	43.6	Equipoise and the ethics of clinical research.	B Freedman	N Engl J Med	1987	3600702	Yes
1974	2665	1332.5	79.87	39.9	EQ-5D: a measure of health status from the EuroQol Group.	R Rabin, F de Charro	Ann Med	2001	11491192	No
1975	1332	1332.0	27.6	27.6	Macromolecular crowding: obvious but underappreciated.	R J Ellis	Trends Biochem Sci	2001	11590012	No
1976	1332	1332.0	0.0	0.0	Immunological function of the thymus.	J F Miller	Lancet	1961	14474038	Yes
1977	3995	1331.7	90.96	30.3	TOR signaling in growth and metabolism.	Stephan Wullschleger, Robbie Loewith, Michael N Hall	Cell	2006	16469695	No
1978	2660	1330.0	0.0	0.0	Selective loss of central cholinergic neurons in Alzheimer's disease.	P Davies, A J Maloney	Lancet	1976	63862	Yes
1979	1330	1330.0	37.86	37.9	The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.	R G Gerrity	Am J Pathol	1981	7234961	Yes
1980	1330	1330.0	29.05	29.1	The Buccaneer software for automated model building. 1. Tracing protein chains.	Kevin Cowtan	Acta Crystallogr D Biol Crystallogr	2006	16929101	Yes
1981	2660	1330.0	86.18	43.1	Mechanisms of salinity tolerance.	Rana Munns, Mark Tester	Annu Rev Plant Biol	2008	18444910	No
1982	1329	1329.0	0.0	0.0	The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models.	R C Lewontin	Genetics	1964	17248194	Yes
1983	2656	1328.0	67.25	33.6	Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule.	M D Pierschbacher, E Ruoslahti	Nature	1984	6325925	Yes
1984	2655	1327.5	76.98	38.5	Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis.	F D Lublin, S C Reingold	Neurology	1996	8780061	Yes
1985	11945	1327.2	449.56	50.0	STAR: ultrafast universal RNA-seq aligner.	Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R Gingeras	Bioinformatics	2013	23104886	Yes
1986	1327	1327.0	45.19	45.2	Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology.	N Krieger	Am J Public Health	1992	1566949	Yes
1987	1327	1327.0	41.57	41.6	Neurotransmitters and neuromodulators in the basal ganglia.	A M Graybiel	Trends Neurosci	1990	1695398	No
1988	1327	1327.0	36.33	36.3	Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies.	S L Friedman	N Engl J Med	1993	8502273	No
1989	1326	1326.0	0.0	0.0	Stereological principles for morphometry in electron microscopic cytology.	E R Weibel	Int Rev Cytol	1969	4899604	No
1990	1326	1326.0	36.16	36.2	A more meaningful scoring system for determining the severity of coronary heart disease.	G G Gensini	Am J Cardiol	1983	6823874	Yes
1991	1325	1325.0	32.32	32.3	Two pathogenetic types of endometrial carcinoma.	J V Bokhman	Gynecol Oncol	1983	6822361	Yes
1992	1325	1325.0	40.96	41.0	Semiempirical hybrid density functional with perturbative second-order correlation.	Stefan Grimme	J Chem Phys	2006	16438568	Yes
1993	2648	1324.0	110.45	55.2	Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use.	A Y Finlay, G K Khan	Clin Exp Dermatol	1994	8033378	Yes
1994	1323	1323.0	0.0	0.0	Electrophoretic separation of plasma lipoproteins in agarose gel.	R P Noble	J Lipid Res	1968	4176473	Yes
1995	2646	1323.0	0.0	0.0	Peptidoglycan types of bacterial cell walls and their taxonomic implications.	K H Schleifer, O Kandler	Bacteriol Rev	1972	4568761	No
1996	2646	1323.0	0.0	0.0	Immunization of dissociated spleen cell cultures from normal mice.	R I Mishell, R W Dutton	J Exp Med	1967	6034749	Yes
1997	1323	1323.0	65.09	65.1	Molecular pathology of schizophrenia: more than one disease process?	T J Crow	Br Med J	1980	6101544	No
1998	1323	1323.0	33.04	33.0	Oxidative stress in Parkinson's disease.	Peter Jenner	Ann Neurol	2003	12666096	No
1999	2645	1322.5	0.0	0.0	Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G.	E Engvall, P Perlmann	Immunochemistry	1971	5135623	Yes
2000	1322	1322.0	25.02	25.0	The DNA methyltransferases of mammals.	T H Bestor	Hum Mol Genet	2000	11005794	No
2001	1322	1322.0	35.66	35.7	Hydrogels for biomedical applications.	Allan S Hoffman	Adv Drug Deliv Rev	2002	11755703	No
2002	1321	1321.0	31.25	31.2	Hematopoietic stem-cell transplantation.	Edward A Copelan	N Engl J Med	2006	16641398	No
2003	2641	1320.5	94.8	47.4	A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels.	C M Tsai, C E Frasch	Anal Biochem	1982	6176137	Yes
2004	2641	1320.5	82.99	41.5	From best evidence to best practice: effective implementation of change in patients' care.	Richard Grol, Jeremy Grimshaw	Lancet	2003	14568747	No
2005	1320	1320.0	0.0	0.0	Origin of concatemeric T7 DNA.	J D Watson	Nat New Biol	1972	4507727	Yes
2006	1320	1320.0	27.27	27.3	Dimerization of cell surface receptors in signal transduction.	C H Heldin	Cell	1995	7834741	No
2007	2640	1320.0	68.67	34.3	Molecular beacons: probes that fluoresce upon hybridization.	S Tyagi, F R Kramer	Nat Biotechnol	1996	9630890	Yes
2008	2640	1320.0	105.91	53.0	Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants.	Sarvajeet Singh Gill, Narendra Tuteja	Plant Physiol Biochem	2010	20870416	No
2009	1320	1320.0	66.03	66.0	Gctf: Real-time CTF determination and correction.	Kai Zhang	J Struct Biol	2016	26592709	Yes
2010	2639	1319.5	95.55	47.8	The Oswestry Disability Index.	J C Fairbank, P B Pynsent	Spine (Phila Pa 1976)	2000	11074683	No
2011	3957	1319.0	100.08	33.4	Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets.	Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck Ørntoft	Cancer Res	2004	15289330	Yes
2012	2637	1318.5	0.0	0.0	Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.	G Blobel, B Dobberstein	J Cell Biol	1975	811671	Yes
2013	1318	1318.0	0.0	0.0	Renin-angiotensin system: biochemistry and mechanisms of action.	M J Peach	Physiol Rev	1977	191856	No
2014	1318	1318.0	0.0	0.0	A quantitative immunochemical measure of the primary interaction between I BSA and antibody.	R S Farr	J Infect Dis	1958	13611294	Yes
2015	1318	1318.0	34.68	34.7	The amygdala modulates the consolidation of memories of emotionally arousing experiences.	James L McGaugh	Annu Rev Neurosci	2004	15217324	No
2016	2635	1317.5	54.58	27.3	Cancer genes and the pathways they control.	Bert Vogelstein, Kenneth W Kinzler	Nat Med	2004	15286780	No
2017	1317	1317.0	47.65	47.6	Neuropeptide Y: complete amino acid sequence of the brain peptide.	K Tatemoto	Proc Natl Acad Sci U S A	1982	6957876	Yes
2018	1317	1317.0	61.85	61.9	Pro-resolving lipid mediators are leads for resolution physiology.	Charles N Serhan	Nature	2014	24899309	No
2019	1316	1316.0	33.7	33.7	The use of nanocrystals in biological detection.	Paul Alivisatos	Nat Biotechnol	2004	14704706	Yes
2020	5262	1315.5	125.36	31.3	Quantitative monitoring of gene expression patterns with a complementary DNA microarray.	M Schena, D Shalon, R W Davis, P O Brown	Science	1995	7569999	Yes
2021	2631	1315.5	0.0	0.0	Virus interference. I. The interferon.	A Isaacs, J Lindenmann	Proc R Soc Lond B Biol Sci	1957	13465720	Yes
2022	7892	1315.3	272.85	45.5	New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0.	Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier Gascuel	Syst Biol	2010	20525638	Yes
2023	1315	1315.0	0.0	0.0	Cellular resistance to infection.	G B Mackaness	J Exp Med	1962	14467923	Yes
2024	2630	1315.0	56.55	28.3	Intrinsically unstructured proteins and their functions.	H Jane Dyson, Peter E Wright	Nat Rev Mol Cell Biol	2005	15738986	No
2025	2630	1315.0	68.76	34.4	Unravelling the pathogenesis of inflammatory bowel disease.	R J Xavier, D K Podolsky	Nature	2007	17653185	No
2026	1314	1314.0	41.44	41.4	Domino Reactions in Organic Synthesis.	Lutz F. Tietze	Chem Rev	1996	11848746	Yes
2027	1313	1313.0	26.07	26.1	Chromosomal translocations in human cancer.	T H Rabbitts	Nature	1994	7969446	No
2028	1313	1313.0	0.0	0.0	The antidiuretic hormone and the factors which determine its release.	E B Verney	Proc R Soc Lond B Biol Sci	1947	18918876	Yes
2029	3938	1312.7	139.69	46.6	Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions.	Aleksandr V Marenich, Christopher J Cramer, Donald G Truhlar	J Phys Chem B	2009	19366259	Yes
2030	2623	1311.5	0.0	0.0	Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans.	D H Figurski, D R Helinski	Proc Natl Acad Sci U S A	1979	377280	Yes
2031	1311	1311.0	0.0	0.0	Stimulus-secretion coupling: the concept and clues from chromaffin and other cells.	W W Douglas	Br J Pharmacol	1968	4882190	No
2032	1311	1311.0	25.47	25.5	Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy.	M G Gustafsson	J Microsc	2000	10810003	Yes
2033	2621	1310.5	60.84	30.4	Integrins and signal transduction pathways: the road taken.	E A Clark, J S Brugge	Science	1995	7716514	No
2034	2619	1309.5	51.19	25.6	Oncogenic kinase signalling.	P Blume-Jensen, T Hunter	Nature	2001	11357143	No
2035	1309	1309.0	34.54	34.5	The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure.	K Kuwajima	Proteins	1989	2695928	No
2036	1309	1309.0	35.33	35.3	Fibronectin and its receptors.	E Ruoslahti	Annu Rev Biochem	1988	2972252	No
2037	1309	1309.0	32.11	32.1	Neurotrophin-regulated signalling pathways.	Louis F Reichardt	Philos Trans R Soc Lond B Biol Sci	2006	16939974	No
2038	1308	1308.0	0.0	0.0	Letter: Grading of angina pectoris.	L Campeau	Circulation	1976	947585	Yes
2039	1308	1308.0	41.79	41.8	The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat.	L W Swanson	Brain Res Bull	1982	6816390	Yes
2040	2615	1307.5	59.85	29.9	Supercoil sequencing: a fast and simple method for sequencing plasmid DNA.	E Y Chen, P H Seeburg	DNA	1985	3996185	Yes
2041	2614	1307.0	60.33	30.2	Self-assembly at all scales.	George M Whitesides, Bartosz Grzybowski	Science	2002	11923529	Yes
2042	3921	1307.0	142.07	47.4	Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration.	Helga Thorvaldsdóttir, James T Robinson, Jill P Mesirov	Brief Bioinform	2013	22517427	Yes
2043	16981	1306.2	481.78	37.1	Clustal W and Clustal X version 2.0.	M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G Higgins	Bioinformatics	2007	17846036	Yes
2044	1306	1306.0	42.94	42.9	History of the Rochester Epidemiology Project.	L J Melton	Mayo Clin Proc	1996	8594285	No
2045	1306	1306.0	30.72	30.7	The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes.	S E Kahn	Diabetologia	2003	12637977	No
2046	1305	1305.0	0.0	0.0	Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism.	H M Kalckar	J Biol Chem	1947	20285041	Yes
2047	1304	1304.0	41.55	41.5	The phenomenon of the acute phase response.	I Kushner	Ann N Y Acad Sci	1982	7046585	No
2048	1304	1304.0	31.47	31.5	Apoptosis in cancer therapy: crossing the threshold.	D E Fisher	Cell	1994	8069905	No
2049	1304	1304.0	0.0	0.0	Agammaglobulinemia.	O C Bruton	Pediatrics	1952	14929630	Yes
2050	1303	1303.0	36.09	36.1	The world health report 2002 - reducing risks, promoting healthy life.	J J Guilbert	Educ Health (Abingdon)	2003	14741909	Yes
2051	3907	1302.3	129.04	43.0	Estimating the mean and variance from the median, range, and the size of a sample.	Stela Pudar Hozo, Benjamin Djulbegovic, Iztok Hozo	BMC Med Res Methodol	2005	15840177	Yes
2052	1302	1302.0	37.27	37.3	The matrix-degrading metalloproteinases.	L M Matrisian	Bioessays	1992	1445287	No
2053	3906	1302.0	98.02	32.7	The p53 tumour suppressor gene.	A J Levine, J Momand, C A Finlay	Nature	1991	2046748	No
2054	2604	1302.0	60.85	30.4	The RXR heterodimers and orphan receptors.	D J Mangelsdorf, R M Evans	Cell	1995	8521508	No
2055	1302	1302.0	34.26	34.3	N-heterocyclic carbenes: a new concept in organometallic catalysis.	Wolfgang A Herrmann	Angew Chem Int Ed Engl	2002	19750753	Yes
2056	5206	1301.5	307.72	76.9	Prevalence of childhood and adult obesity in the United States, 2011-2012.	Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M Flegal	JAMA	2014	24570244	Yes
2057	1301	1301.0	28.17	28.2	Double identity for proteins of the Bcl-2 family.	J C Reed	Nature	1997	9194558	No
2058	1301	1301.0	46.59	46.6	The polyvagal perspective.	Stephen W Porges	Biol Psychol	2007	17049418	No
2059	2599	1299.5	61.68	30.8	The pathophysiology and treatment of sepsis.	Richard S Hotchkiss, Irene E Karl	N Engl J Med	2003	12519925	No
2060	1299	1299.0	50.55	50.5	Free-radical mechanisms in tissue injury.	T F Slater	Biochem J	1984	6383353	No
2061	2598	1299.0	78.19	39.1	Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9164317	Yes
2062	1298	1298.0	44.43	44.4	Gene flow and the geographic structure of natural populations.	M Slatkin	Science	1987	3576198	Yes
2063	1298	1298.0	29.64	29.6	Functions of the neurotrophins during nervous system development: what the knockouts are teaching us.	W D Snider	Cell	1994	8205613	No
2064	1298	1298.0	41.07	41.1	Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research.	M Robin DiMatteo	Med Care	2004	15076819	Yes
2065	1296	1296.0	33.67	33.7	Lead- and drug-like compounds: the rule-of-five revolution.	Christopher A Lipinski	Drug Discov Today Technol	2004	24981612	Yes
2066	1296	1296.0	73.12	73.1	The biology and function of fibroblasts in cancer.	Raghu Kalluri	Nat Rev Cancer	2016	27550820	No
2067	5181	1295.2	141.53	35.4	Most mammalian mRNAs are conserved targets of microRNAs.	Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel	Genome Res	2009	18955434	Yes
2068	1295	1295.0	32.92	32.9	Tobacco smoke carcinogens and lung cancer.	S S Hecht	J Natl Cancer Inst	1999	10413421	No
2069	1295	1295.0	25.87	25.9	Epithelial-mesenchymal transitions in development and pathologies.	Jean Paul Thiery	Curr Opin Cell Biol	2003	14644200	No
2070	1293	1293.0	30.67	30.7	Hyaluronan: from extracellular glue to pericellular cue.	Bryan P Toole	Nat Rev Cancer	2004	15229478	No
2071	1293	1293.0	43.91	43.9	Stress signalling pathways that impair prefrontal cortex structure and function.	Amy F T Arnsten	Nat Rev Neurosci	2009	19455173	No
2072	2586	1293.0	112.78	56.4	Regulation of microRNA biogenesis.	Minju Ha, V Narry Kim	Nat Rev Mol Cell Biol	2014	25027649	No
2073	2585	1292.5	54.09	27.0	Wnt signalling in stem cells and cancer.	Tannishtha Reya, Hans Clevers	Nature	2005	15829953	No
2074	1292	1292.0	29.57	29.6	Cancer of the ovary.	Stephen A Cannistra	N Engl J Med	2004	15590954	No
2075	2582	1291.0	61.77	30.9	Production of single-stranded plasmid DNA.	J Vieira, J Messing	Methods Enzymol	1987	3323803	Yes
2076	1291	1291.0	31.45	31.4	Regulation of differentiation of vascular smooth muscle cells.	G K Owens	Physiol Rev	1995	7624392	No
2077	1291	1291.0	29.41	29.4	A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other.	Dale R Nyholt	Am J Hum Genet	2004	14997420	Yes
2078	1290	1290.0	0.0	0.0	Stability of proteins: small globular proteins.	P L Privalov	Adv Protein Chem	1979	44431	No
2079	1290	1290.0	41.77	41.8	Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia.	A A Grace	Neuroscience	1991	1676137	No
2080	1289	1289.0	34.96	35.0	Signaling through phosphatidylcholine breakdown.	J H Exton	J Biol Chem	1990	2104616	No
2081	1289	1289.0	50.1	50.1	Presidential address, 1980. Surprise!...Surprise?	E Donchin	Psychophysiology	1981	7280146	Yes
2082	2578	1289.0	95.75	47.9	Saliency, switching, attention and control: a network model of insula function.	Vinod Menon, Lucina Q Uddin	Brain Struct Funct	2010	20512370	No
2083	1289	1289.0	80.86	80.9	Deep learning in neural networks: an overview.	Jürgen Schmidhuber	Neural Netw	2015	25462637	No
2084	3866	1288.7	117.25	39.1	Regularization Paths for Generalized Linear Models via Coordinate Descent.	Jerome Friedman, Trevor Hastie, Rob Tibshirani	J Stat Softw	2010	20808728	Yes
2085	2577	1288.5	76.93	38.5	Materials for electrochemical capacitors.	Patrice Simon, Yury Gogotsi	Nat Mater	2008	18956000	Yes
2086	1288	1288.0	28.14	28.1	The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats.	G B Morin	Cell	1989	2805070	Yes
2087	1288	1288.0	47.38	47.4	Substance P.	B Pernow	Pharmacol Rev	1983	6196797	No
2088	1288	1288.0	43.11	43.1	The functional gastrointestinal disorders and the Rome III process.	Douglas A Drossman	Gastroenterology	2006	16678553	No
2089	2575	1287.5	56.13	28.1	The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.	M S Brown, J L Goldstein	Cell	1997	9150132	No
2090	3862	1287.3	89.5	29.8	Osteoclast differentiation and activation.	William J Boyle, W Scott Simonet, David L Lacey	Nature	2003	12748652	No
2091	1287	1287.0	33.66	33.7	Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides.	Y Shai	Biochim Biophys Acta	1999	10590302	No
2092	2573	1286.5	0.0	0.0	Epidermal growth factor.	G Carpenter, S Cohen	Annu Rev Biochem	1979	382984	No
2093	2572	1286.0	0.0	0.0	Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens.	J A Ledbetter, L A Herzenberg	Immunol Rev	1979	398327	No
2094	1286	1286.0	24.3	24.3	Chromatin modification and epigenetic reprogramming in mammalian development.	En Li	Nat Rev Genet	2002	12209141	No
2095	2571	1285.5	0.0	0.0	A new scale of social desirability independent of psychopathology.	D P Crowne, D Marlowe	J Consult Psychol	1960	13813058	Yes
2096	1285	1285.0	31.1	31.1	Receptors for epidermal growth factor and other polypeptide mitogens.	G Carpenter	Annu Rev Biochem	1987	3039909	No
2097	1285	1285.0	0.0	0.0	Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents.	A Böyum	Scand J Clin Lab Invest Suppl	1968	4179066	Yes
2098	1285	1285.0	33.06	33.1	A molecular view of microbial diversity and the biosphere.	N R Pace	Science	1997	9115194	No
2099	1285	1285.0	27.43	27.4	Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators.	R I Morimoto	Genes Dev	1998	9869631	No
2100	2569	1284.5	0.0	0.0	A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants.	R L Juliano, V Ling	Biochim Biophys Acta	1976	990323	Yes
2101	2569	1284.5	71.71	35.9	Macrophage diversity enhances tumor progression and metastasis.	Bin-Zhi Qian, Jeffrey W Pollard	Cell	2010	20371344	No
2102	2568	1284.0	0.0	0.0	Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents.	L F Berkman, S L Syme	Am J Epidemiol	1979	425958	Yes
2103	1284	1284.0	34.25	34.2	Phylogenies from molecular sequences: inference and reliability.	J Felsenstein	Annu Rev Genet	1988	3071258	No
2104	1284	1284.0	30.48	30.5	Molecular basis of long-term plasticity underlying addiction.	E J Nestler	Nat Rev Neurosci	2001	11252991	No
2105	3852	1284.0	172.58	57.5	Molecular mechanisms of epithelial-mesenchymal transition.	Samy Lamouille, Jian Xu, Rik Derynck	Nat Rev Mol Cell Biol	2014	24556840	No
2106	2568	1284.0	118.94	59.5	Deciphering key features in protein structures with the new ENDscript server.	Xavier Robert, Patrice Gouet	Nucleic Acids Res	2014	24753421	Yes
2107	2567	1283.5	0.0	0.0	Regulatory sequences involved in the promotion and termination of RNA transcription.	M Rosenberg, D Court	Annu Rev Genet	1979	94251	No
2108	1283	1283.0	53.8	53.8	Sample size in qualitative research.	M Sandelowski	Res Nurs Health	1995	7899572	Yes
2109	2566	1283.0	59.41	29.7	Disruption of epithelial cell-matrix interactions induces apoptosis.	S M Frisch, H Francis	J Cell Biol	1994	8106557	Yes
2110	3848	1282.7	0.0	0.0	Improved method for the determination of blood glutathione.	E Beutler, O Duron, B M Kelly	J Lab Clin Med	1963	13967893	Yes
2111	2565	1282.5	54.76	27.4	Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.	J M Kyriakis, J Avruch	Physiol Rev	2001	11274345	No
2112	1282	1282.0	0.0	0.0	Cardiovascular and renal actions of dopamine: potential clinical applications.	L I Goldberg	Pharmacol Rev	1972	4554480	No
2113	1282	1282.0	30.08	30.1	Autophagy: from phenomenology to molecular understanding in less than a decade.	Daniel J Klionsky	Nat Rev Mol Cell Biol	2007	17712358	No
2114	1281	1281.0	36.21	36.2	Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease.	Michael F Holick	Am J Clin Nutr	2004	15585788	No
2115	1281	1281.0	47.48	47.5	The global impact of pre-eclampsia and eclampsia.	Lelia Duley	Semin Perinatol	2009	19464502	No
2116	6403	1280.6	289.4	57.9	UCHIME improves sensitivity and speed of chimera detection.	Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob Knight	Bioinformatics	2011	21700674	Yes
2117	2561	1280.5	56.68	28.3	NMR View: A computer program for the visualization and analysis of NMR data.	B A Johnson, R A Blevins	J Biomol NMR	1994	22911360	Yes
2118	1280	1280.0	0.0	0.0	Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action.	J H Luft	Anat Rec	1971	4108333	Yes
2119	3840	1280.0	101.96	34.0	Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system.	B Fischl, M I Sereno, A M Dale	Neuroimage	1999	9931269	Yes
2120	1280	1280.0	35.66	35.7	A note on robust variance estimation for cluster-correlated data.	R L Williams	Biometrics	2000	10877330	Yes
2121	1280	1280.0	24.36	24.4	CD95's deadly mission in the immune system.	P H Krammer	Nature	2000	11048730	No
2122	1279	1279.0	26.5	26.5	Natively unfolded proteins: a point where biology waits for physics.	Vladimir N Uversky	Protein Sci	2002	11910019	No
2123	2558	1279.0	60.3	30.1	A comparison of bayesian methods for haplotype reconstruction from population genotype data.	Matthew Stephens, Peter Donnelly	Am J Hum Genet	2003	14574645	Yes
2124	5114	1278.5	128.79	32.2	Improved prediction of signal peptides: SignalP 3.0.	Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren Brunak	J Mol Biol	2004	15223320	Yes
2125	1278	1278.0	22.24	22.2	Cancer. Addiction to oncogenes--the Achilles heal of cancer.	I Bernard Weinstein	Science	2002	12098689	No
2126	1278	1278.0	64.27	64.3	What's in a name? Qualitative description revisited.	Margarete Sandelowski	Res Nurs Health	2010	20014004	Yes
2127	1277	1277.0	29.13	29.1	The ATP synthase--a splendid molecular machine.	P D Boyer	Annu Rev Biochem	1997	9242922	No
2128	1277	1277.0	0.0	0.0	The Relation Of Recombination To Mutational Advance.	H J Muller	Mutat Res	1964	14195748	Yes
2129	3830	1276.7	138.26	46.1	Structure-antioxidant activity relationships of flavonoids and phenolic acids.	C A Rice-Evans, N J Miller, G Paganga	Free Radic Biol Med	1996	8743980	Yes
2130	1276	1276.0	0.0	0.0	Hippocampal electrical activity and voluntary movement in the rat.	C H Vanderwolf	Electroencephalogr Clin Neurophysiol	1969	4183562	Yes
2131	2550	1275.0	0.0	0.0	A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival.	B G Durie, S E Salmon	Cancer	1975	1182674	Yes
2132	1275	1275.0	84.98	85.0	The three column spine and its significance in the classification of acute thoracolumbar spinal injuries.	F Denis	Spine (Phila Pa 1976)	1983	6670016	Yes
2133	1275	1275.0	30.75	30.8	Lymphokine production by human T cells in disease states.	S Romagnani	Annu Rev Immunol	1994	8011282	No
2134	1275	1275.0	32.61	32.6	Upconversion and anti-Stokes processes with f and d ions in solids.	François Auzel	Chem Rev	2004	14719973	Yes
2135	1275	1275.0	32.97	33.0	Drug-induced prolongation of the QT interval.	Dan M Roden	N Engl J Med	2004	14999113	No
2136	1275	1275.0	34.07	34.1	Origin, biogenesis, and activity of plant microRNAs.	Olivier Voinnet	Cell	2009	19239888	No
2137	1274	1274.0	0.0	0.0	Mate selection-a selection for a handicap.	A Zahavi	J Theor Biol	1975	1195756	Yes
2138	2548	1274.0	51.39	25.7	Autophagy as a regulated pathway of cellular degradation.	D J Klionsky, S D Emr	Science	2000	11099404	No
2139	1274	1274.0	44.98	45.0	Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains.	K Anders Ericsson	Acad Med	2004	15383395	No
2140	1274	1274.0	40.04	40.0	Recent developments in isocyanide based multicomponent reactions in applied chemistry.	Alexander Dömling	Chem Rev	2006	16402771	No
2141	2547	1273.5	47.4	23.7	New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites.	R D Gietz, A Sugino	Gene	1988	3073106	Yes
2142	1273	1273.0	44.65	44.6	Functional organization of central pathways regulating the cardiovascular system.	R A Dampney	Physiol Rev	1994	8171117	No
2143	3818	1272.7	182.73	60.9	Risk factors for falls among elderly persons living in the community.	M E Tinetti, M Speechley, S F Ginter	N Engl J Med	1988	3205267	Yes
2144	2545	1272.5	43.03	21.5	Genetic transformation of Drosophila with transposable element vectors.	G M Rubin, A C Spradling	Science	1982	6289436	Yes
2145	1272	1272.0	38.89	38.9	Diversity and ubiquity of K channels.	B Rudy	Neuroscience	1988	2457185	No
2146	1272	1272.0	24.14	24.1	Antigen-specific interaction between T and B cells.	A Lanzavecchia	Nature	1985	3157869	Yes
2147	1272	1272.0	55.28	55.3	The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence.	E J Khantzian	Am J Psychiatry	1985	3904487	No
2148	2542	1271.0	76.31	38.2	Lipid rafts as a membrane-organizing principle.	Daniel Lingwood, Kai Simons	Science	2010	20044567	No
2149	8889	1269.9	447.94	64.0	limma powers differential expression analyses for RNA-sequencing and microarray studies.	Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth	Nucleic Acids Res	2015	25605792	Yes
2150	5078	1269.5	129.78	32.4	The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling.	Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten Schwede	Bioinformatics	2006	16301204	Yes
2151	1269	1269.0	41.93	41.9	Somatostatin.	S Reichlin	N Engl J Med	1983	6139753	No
2152	1269	1269.0	35.47	35.5	The epidemiology of venous thromboembolism.	Richard H White	Circulation	2003	12814979	No
2153	2536	1268.0	0.0	0.0	Establishment and characterization of a human histiocytic lymphoma cell line (U-937).	C Sundström, K Nilsson	Int J Cancer	1976	178611	Yes
2154	1268	1268.0	33.69	33.7	The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.	T Szkudelski	Physiol Res	2001	11829314	No
2155	1268	1268.0	0.0	0.0	Quantitative Genetic Analysis Of Multivariate Evolution, Applied To Brain:Body Size Allometry.	Russell Lande	Evolution	1979	28568194	Yes
2156	1267	1267.0	23.24	23.2	Regulatory T cells: key controllers of immunologic self-tolerance.	S Sakaguchi	Cell	2000	10850488	No
2157	2534	1267.0	81.59	40.8	Protective and pathogenic functions of macrophage subsets.	Peter J Murray, Thomas A Wynn	Nat Rev Immunol	2011	21997792	No
2158	1267	1267.0	87.31	87.3	The antibiotic resistance crisis: part 1: causes and threats.	C Lee Ventola	P T	2015	25859123	Yes
2159	1266	1266.0	49.55	49.5	Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies.	Peter C Austin	Pharm Stat	2011	20925139	Yes
2160	2530	1265.0	0.0	0.0	Glutathione peroxidase activity in selenium-deficient rat liver.	R A Lawrence, R F Burk	Biochem Biophys Res Commun	1976	971321	Yes
2161	2530	1265.0	55.43	27.7	Liver regeneration.	G K Michalopoulos, M C DeFrances	Science	1997	9082986	No
2162	1265	1265.0	34.28	34.3	The importance of the ratio of omega-6/omega-3 essential fatty acids.	A P Simopoulos	Biomed Pharmacother	2002	12442909	No
2163	2529	1264.5	0.0	0.0	Functions of lysosomes.	C De Duve, R Wattiaux	Annu Rev Physiol	1966	5322983	No
2164	1264	1264.0	0.0	0.0	The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C.	R G Khalifah	J Biol Chem	1971	4994926	Yes
2165	1264	1264.0	46.8	46.8	A Social Neuroscience Perspective on Adolescent Risk-Taking.	Laurence Steinberg	Dev Rev	2008	18509515	Yes
2166	2526	1263.0	0.0	0.0	A rapid, sensitive, and specific method for the determination of protein in dilute solution.	W Schaffner, C Weissmann	Anal Biochem	1973	4128882	Yes
2167	2526	1263.0	87.02	43.5	Thermodynamics of protein association reactions: forces contributing to stability.	P D Ross, S Subramanian	Biochemistry	1981	7248271	Yes
2168	1263	1263.0	29.0	29.0	Target-oriented and diversity-oriented organic synthesis in drug discovery.	S L Schreiber	Science	2000	10720315	No
2169	5051	1262.8	223.85	56.0	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	Int J Surg	2010	20171303	No
2170	1262	1262.0	22.74	22.7	Clonal selection and learning in the antibody system.	K Rajewsky	Nature	1996	8657279	No
2171	1262	1262.0	45.31	45.3	The self-medication hypothesis of substance use disorders: a reconsideration and recent applications.	E J Khantzian	Harv Rev Psychiatry	1997	9385000	No
2172	1262	1262.0	23.61	23.6	The snail superfamily of zinc-finger transcription factors.	M Angela Nieto	Nat Rev Mol Cell Biol	2002	11994736	No
2173	2523	1261.5	0.0	0.0	The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites.	J Shine, L Dalgarno	Proc Natl Acad Sci U S A	1974	4598299	Yes
2174	2523	1261.5	49.66	24.8	Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis.	M Fried, D M Crothers	Nucleic Acids Res	1981	6275366	Yes
2175	2521	1260.5	0.0	0.0	Prediction of the secondary structure of proteins from their amino acid sequence.	P Y Chou, G D Fasman	Adv Enzymol Relat Areas Mol Biol	1978	364941	No
2176	1260	1260.0	47.95	48.0	The life and times of the Enterococcus.	B E Murray	Clin Microbiol Rev	1990	2404568	No
2177	1260	1260.0	31.98	32.0	Apoptosis.	J J Cohen	Immunol Today	1993	8466628	No
2178	1260	1260.0	42.12	42.1	Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data.	Thomas Heberer	Toxicol Lett	2002	11988354	Yes
2179	2519	1259.5	62.55	31.3	Multipoint quantitative-trait linkage analysis in general pedigrees.	L Almasy, J Blangero	Am J Hum Genet	1998	9545414	Yes
2180	2516	1258.0	67.62	33.8	Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.	J L Weber, P E May	Am J Hum Genet	1989	2916582	Yes
2181	1258	1258.0	0.0	0.0	Structure and function of intercellular junctions.	L A Staehelin	Int Rev Cytol	1974	4611943	No
2182	1258	1258.0	33.67	33.7	The aryl hydrocarbon receptor complex.	O Hankinson	Annu Rev Pharmacol Toxicol	1995	7598497	No
2183	1258	1258.0	0.0	0.0	A New Weighting System For Mean Surface Temperature Of The Human Body.	N L Ramanathan	J Appl Physiol	1964	14173555	Yes
2184	1257	1257.0	40.23	40.2	Biological basis of the behavior of sick animals.	B L Hart	Neurosci Biobehav Rev	1988	3050629	No
2185	1257	1257.0	0.0	0.0	Strategy and tactics in protein chemistry.	B S Hartley	Biochem J	1970	4923920	No
2186	1257	1257.0	33.4	33.4	Supported membranes: scientific and practical applications.	E Sackmann	Science	1996	8539599	No
2187	1257	1257.0	38.49	38.5	The debate over dopamine's role in reward: the case for incentive salience.	Kent C Berridge	Psychopharmacology (Berl)	2007	17072591	No
2188	2514	1257.0	81.49	40.7	A perspective on cancer cell metastasis.	Christine L Chaffer, Robert A Weinberg	Science	2011	21436443	No
2189	2513	1256.5	89.92	45.0	Measuring emotion: the Self-Assessment Manikin and the Semantic Differential.	M M Bradley, P J Lang	J Behav Ther Exp Psychiatry	1994	7962581	Yes
2190	6282	1256.4	0.0	0.0	Enzymatic determination of total serum cholesterol.	C C Allain, L S Poon, C S Chan, W Richmond, P C Fu	Clin Chem	1974	4818200	Yes
2191	1256	1256.0	26.2	26.2	SETOR: hardware-lighted three-dimensional solid model representations of macromolecules.	S V Evans	J Mol Graph	1993	8347566	Yes
2192	1256	1256.0	35.37	35.4	Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications.	P Lips	Endocr Rev	2001	11493580	No
2193	1256	1256.0	29.06	29.1	Critical period plasticity in local cortical circuits.	Takao K Hensch	Nat Rev Neurosci	2005	16261181	No
2194	3767	1255.7	103.14	34.4	The metabolic syndrome.	Robert H Eckel, Scott M Grundy, Paul Z Zimmet	Lancet	2005	15836891	No
2195	2510	1255.0	0.0	0.0	Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells.	A Fabiato, F Fabiato	J Physiol (Paris)	1979	533865	Yes
2196	1255	1255.0	52.33	52.3	Error in medicine.	L L Leape	JAMA	1994	7503827	Yes
2197	3765	1255.0	104.96	35.0	TCS: a computer program to estimate gene genealogies.	M Clement, D Posada, K A Crandall	Mol Ecol	2000	11050560	Yes
2198	1255	1255.0	33.69	33.7	Interoception: the sense of the physiological condition of the body.	A D Craig	Curr Opin Neurobiol	2003	12965300	No
2199	2509	1254.5	54.57	27.3	A guided tour into subcellular colocalization analysis in light microscopy.	S Bolte, F P Cordelières	J Microsc	2006	17210054	Yes
2200	1254	1254.0	43.26	43.3	Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells.	R Lotan	Biochim Biophys Acta	1980	6989400	No
2201	1254	1254.0	22.96	23.0	Protein modification by SUMO.	Erica S Johnson	Annu Rev Biochem	2004	15189146	No
2202	3761	1253.7	118.0	39.3	Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria.	S van der Linden, H A Valkenburg, A Cats	Arthritis Rheum	1984	6231933	Yes
2203	3761	1253.7	94.65	31.6	Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies.	Daniel Falush, Matthew Stephens, Jonathan K Pritchard	Genetics	2003	12930761	Yes
2204	1253	1253.0	26.28	26.3	Signal transduction via the MAP kinases: proceed at your own RSK.	J Blenis	Proc Natl Acad Sci U S A	1993	8392180	No
2205	1253	1253.0	42.5	42.5	SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test.	B P O'Connor	Behav Res Methods Instrum Comput	2000	11029811	Yes
2206	1253	1253.0	30.85	30.9	Cell signaling. H2O2, a necessary evil for cell signaling.	Sue Goo Rhee	Science	2006	16809515	Yes
2207	1253	1253.0	42.21	42.2	Formation of glasses from liquids and biopolymers.	C A Angell	Science	1995	17770101	Yes
2208	2505	1252.5	0.0	0.0	A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms.	J A Horne, O Ostberg	Int J Chronobiol	1976	1027738	Yes
2209	1252	1252.0	28.16	28.2	Stability and flexibility of epigenetic gene regulation in mammalian development.	Wolf Reik	Nature	2007	17522676	No
2210	1252	1252.0	0.0	0.0	Limitations of the application of fourfold table analysis to hospital data.	J Berkson	Biometrics	1946	21001024	Yes
2211	1251	1251.0	25.84	25.8	Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy.	R H Schwartz	Cell	1992	1335362	No
2212	1251	1251.0	50.71	50.7	Reliability and factor analysis of the Epworth Sleepiness Scale.	M W Johns	Sleep	1992	1519015	Yes
2213	1251	1251.0	0.0	0.0	The prevalence of 'alexithymic' characteristics in psychosomatic patients.	P E Sifneos	Psychother Psychosom	1973	4770536	Yes
2214	1251	1251.0	43.47	43.5	The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme.	Poul Erik Petersen	Community Dent Oral Epidemiol	2003	15015736	Yes
2215	2501	1250.5	58.08	29.0	DNA sequence analysis with a modified bacteriophage T7 DNA polymerase.	S Tabor, C C Richardson	Proc Natl Acad Sci U S A	1987	3474623	Yes
2216	2500	1250.0	76.47	38.2	What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes.	J Zhang, K F Yu	JAMA	1998	9832001	Yes
2217	1250	1250.0	33.71	33.7	Hemispheric asymmetry reduction in older adults: the HAROLD model.	Roberto Cabeza	Psychol Aging	2002	11931290	No
2218	2500	1250.0	79.14	39.6	miRBase: integrating microRNA annotation and deep-sequencing data.	Ana Kozomara, Sam Griffiths-Jones	Nucleic Acids Res	2011	21037258	Yes
2219	1249	1249.0	0.0	0.0	A modification of receptor theory.	R P Stephenson	Br J Pharmacol Chemother	1956	13383117	Yes
2220	1249	1249.0	23.8	23.8	The significance of responses of the genome to challenge.	B McClintock	Science	1984	15739260	No
2221	1248	1248.0	47.36	47.4	Quantitative methods in the review of epidemiologic literature.	S Greenland	Epidemiol Rev	1987	3678409	Yes
2222	1247	1247.0	28.36	28.4	Life, death, and the pursuit of apoptosis.	E White	Genes Dev	1996	8557188	No
2223	2494	1247.0	0.0	0.0	The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid.	B N Ames, D T Dubin	J Biol Chem	1960	13793161	Yes
2224	2493	1246.5	78.96	39.5	Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.	J E Hixson, D T Vernier	J Lipid Res	1990	2341813	Yes
2225	1246	1246.0	28.81	28.8	Chemistry and biology of the immunophilins and their immunosuppressive ligands.	S L Schreiber	Science	1991	1702904	No
2226	1246	1246.0	28.44	28.4	Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration.	T A Springer	Annu Rev Physiol	1995	7778885	No
2227	8716	1245.1	273.51	39.1	Cancer statistics, 2008.	Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J Thun	CA Cancer J Clin	2008	18287387	Yes
2228	1245	1245.0	44.73	44.7	Carnitine--metabolism and functions.	J Bremer	Physiol Rev	1983	6361812	No
2229	1245	1245.0	38.34	38.3	Osteoblast adhesion on biomaterials.	K Anselme	Biomaterials	2000	10711964	No
2230	2490	1245.0	55.94	28.0	Mitochondrial control of cell death.	G Kroemer, J C Reed	Nat Med	2000	10802706	No
2231	1245	1245.0	36.89	36.9	Bioactive microbial metabolites.	János Bérdy	J Antibiot (Tokyo)	2005	15813176	No
2232	3734	1244.7	100.84	33.6	How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.	R M Sapolsky, L M Romero, A U Munck	Endocr Rev	2000	10696570	No
2233	1244	1244.0	30.45	30.4	Papillomavirus infections--a major cause of human cancers.	H zur Hausen	Biochim Biophys Acta	1996	8876633	No
2234	1244	1244.0	29.57	29.6	Mitochondria: dynamic organelles in disease, aging, and development.	David C Chan	Cell	2006	16814712	No
2235	1244	1244.0	114.91	114.9	Minimap2: pairwise alignment for nucleotide sequences.	Heng Li	Bioinformatics	2018	29750242	Yes
2236	2487	1243.5	83.73	41.9	The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.	W R Gibb, A J Lees	J Neurol Neurosurg Psychiatry	1988	2841426	No
2237	2487	1243.5	87.68	43.8	The pathogenesis of rheumatoid arthritis.	Iain B McInnes, Georg Schett	N Engl J Med	2011	22150039	No
2238	1243	1243.0	30.42	30.4	Short-term synaptic plasticity.	R S Zucker	Annu Rev Neurosci	1989	2648947	No
2239	2485	1242.5	55.36	27.7	Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information.	M Zuker, P Stiegler	Nucleic Acids Res	1981	6163133	Yes
2240	1242	1242.0	0.0	0.0	Sequential tests for the detection of linkage.	N E Morton	Am J Hum Genet	1955	13258560	Yes
2241	2483	1241.5	66.32	33.2	Apoptosis, oncosis, and necrosis. An overview of cell death.	G Majno, I Joris	Am J Pathol	1995	7856735	No
2242	2483	1241.5	69.05	34.5	Abdominal obesity and metabolic syndrome.	Jean-Pierre Després, Isabelle Lemieux	Nature	2006	17167477	No
2243	3724	1241.3	83.76	27.9	Multidrug resistance in cancer: role of ATP-dependent transporters.	Michael M Gottesman, Tito Fojo, Susan E Bates	Nat Rev Cancer	2002	11902585	No
2244	1241	1241.0	27.17	27.2	Codon usage and tRNA content in unicellular and multicellular organisms.	T Ikemura	Mol Biol Evol	1985	3916708	No
2245	3723	1241.0	81.91	27.3	A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.	R Medzhitov, P Preston-Hurlburt, C A Janeway	Nature	1997	9237759	Yes
2246	1241	1241.0	0.0	0.0	The effective period of preventive antibiotic action in experimental incisions and dermal lesions.	J F Burke	Surgery	1961	16722001	Yes
2247	1240	1240.0	20.49	20.5	Antigen receptor tail clue.	M Reth	Nature	1989	2927501	Yes
2248	2479	1239.5	62.89	31.4	Inflammation, stress, and diabetes.	Kathryn E Wellen, Gökhan S Hotamisligil	J Clin Invest	2005	15864338	No
2249	1239	1239.0	32.81	32.8	Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders.	R M Sapolsky	Arch Gen Psychiatry	2000	11015810	No
2250	3717	1239.0	78.62	26.2	The versatility and universality of calcium signalling.	M J Berridge, P Lipp, M D Bootman	Nat Rev Mol Cell Biol	2000	11413485	No
2251	2475	1237.5	73.18	36.6	Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.	J I Morgan, T Curran	Annu Rev Neurosci	1991	1903243	No
2252	1237	1237.0	42.44	42.4	How is the level of free arachidonic acid controlled in mammalian cells?	R F Irvine	Biochem J	1982	6810878	No
2253	1237	1237.0	25.89	25.9	Searching for genetic determinants in the new millennium.	N J Risch	Nature	2000	10866211	No
2254	2473	1236.5	56.69	28.3	Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface.	D A Brown, J K Rose	Cell	1992	1531449	Yes
2255	1236	1236.0	39.58	39.6	Ordinary magic. Resilience processes in development.	A S Masten	Am Psychol	2001	11315249	Yes
2256	2471	1235.5	80.49	40.2	Astrocytes: biology and pathology.	Michael V Sofroniew, Harry V Vinters	Acta Neuropathol	2010	20012068	No
2257	1235	1235.0	66.89	66.9	The determinants of parenting: a process model.	J Belsky	Child Dev	1984	6705636	Yes
2258	1235	1235.0	62.33	62.3	Chronic illness as biographical disruption.	M Bury	Sociol Health Illn	1982	10260456	Yes
2259	1235	1235.0	39.62	39.6	Graphene transistors.	Frank Schwierz	Nat Nanotechnol	2010	20512128	Yes
2260	1234	1234.0	0.0	0.0	Bee and wasp venoms.	E Habermann	Science	1972	4113805	No
2261	2468	1234.0	87.11	43.6	The framing of decisions and the psychology of choice.	A Tversky, D Kahneman	Science	1981	7455683	Yes
2262	1234	1234.0	35.44	35.4	Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects.	E B Hunziker	Osteoarthritis Cartilage	2002	12056848	No
2263	1233	1233.0	0.0	0.0	The origin of the genetic code.	F H Crick	J Mol Biol	1968	4887876	Yes
2264	1233	1233.0	25.84	25.8	Endocytosis and molecular sorting.	I Mellman	Annu Rev Cell Dev Biol	1996	8970738	No
2265	1233	1233.0	26.66	26.7	The many faces of macrophage activation.	David M Mosser	J Leukoc Biol	2003	12554797	No
2266	1233	1233.0	46.13	46.1	Matching methods for causal inference: A review and a look forward.	Elizabeth A Stuart	Stat Sci	2010	20871802	Yes
2267	2465	1232.5	45.87	22.9	Rab proteins as membrane organizers.	M Zerial, H McBride	Nat Rev Mol Cell Biol	2001	11252952	No
2268	2464	1232.0	90.81	45.4	The stunned myocardium: prolonged, postischemic ventricular dysfunction.	E Braunwald, R A Kloner	Circulation	1982	6754130	No
2269	2464	1232.0	52.16	26.1	Short-term synaptic plasticity.	Robert S Zucker, Wade G Regehr	Annu Rev Physiol	2002	11826273	No
2270	1232	1232.0	0.0	0.0	On the local reactions of the arterial wall to changes of internal pressure.	W M Bayliss	J Physiol	1902	16992618	Yes
2271	1232	1232.0	47.81	47.8	Functional and effective connectivity: a review.	Karl J Friston	Brain Connect	2011	22432952	No
2272	6158	1231.6	151.0	30.2	Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.	T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L Coffman	J Immunol	1986	2419430	Yes
2273	1231	1231.0	38.84	38.8	Strong localization of photons in certain disordered dielectric superlattices.	John	Phys Rev Lett	1987	10034761	Yes
2274	1231	1231.0	35.36	35.4	Synergy, antagonism, and what the chequerboard puts between them.	F C Odds	J Antimicrob Chemother	2003	12805255	No
2275	2461	1230.5	93.15	46.6	Universal chemical assay for the detection and determination of siderophores.	B Schwyn, J B Neilands	Anal Biochem	1987	2952030	Yes
2276	2461	1230.5	57.51	28.8	Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry.	Joshua E Elias, Steven P Gygi	Nat Methods	2007	17327847	Yes
2277	2461	1230.5	74.36	37.2	The Measurement Of Selection On Correlated Characters.	Russell Lande, Stevan J Arnold	Evolution	1983	28556011	Yes
2278	4920	1230.0	147.95	37.0	Reversible middle cerebral artery occlusion without craniectomy in rats.	E Z Longa, P R Weinstein, S Carlson, R Cummins	Stroke	1989	2643202	Yes
2279	1230	1230.0	23.11	23.1	c-Myc target genes involved in cell growth, apoptosis, and metabolism.	C V Dang	Mol Cell Biol	1999	9858526	No
2280	2460	1230.0	0.0	0.0	Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines.	G J Todaro, H Green	J Cell Biol	1963	13985244	Yes
2281	1230	1230.0	45.65	45.6	Phase retrieval algorithms: a comparison.	J R Fienup	Appl Opt	1982	20396114	Yes
2282	2459	1229.5	52.1	26.1	The molecular biology of axon guidance.	M Tessier-Lavigne, C S Goodman	Science	1996	8895455	No
2283	2459	1229.5	74.09	37.0	Molecular mechanisms of long noncoding RNAs.	Kevin C Wang, Howard Y Chang	Mol Cell	2011	21925379	No
2284	1229	1229.0	24.95	24.9	STATs: signal transducers and activators of transcription.	J N Ihle	Cell	1996	8608586	No
2285	1228	1228.0	45.05	45.0	The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria.	A Raine	Schizophr Bull	1991	1805349	Yes
2286	1228	1228.0	0.0	0.0	Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus.	P Rakic	J Comp Neurol	1971	4101340	Yes
2287	2456	1228.0	63.94	32.0	Long short-term memory.	S Hochreiter, J Schmidhuber	Neural Comput	1997	9377276	Yes
2288	1228	1228.0	27.39	27.4	HIF-1: mediator of physiological and pathophysiological responses to hypoxia.	G L Semenza	J Appl Physiol (1985)	2000	10749844	No
2289	1228	1228.0	39.11	39.1	Understanding organofluorine chemistry. An introduction to the C-F bond.	David O'Hagan	Chem Soc Rev	2008	18197347	No
2290	1227	1227.0	33.94	33.9	Understanding biofilm resistance to antibacterial agents.	David Davies	Nat Rev Drug Discov	2003	12563302	No
2291	2451	1225.5	47.93	24.0	Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection.	C Li, W H Wong	Proc Natl Acad Sci U S A	2001	11134512	Yes
2292	1225	1225.0	34.75	34.8	Tumor angiogenesis.	J Folkman	Adv Cancer Res	1985	2581424	No
2293	6124	1224.8	191.73	38.3	Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication.	Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E Walters	Arch Gen Psychiatry	2005	15939839	Yes
2294	7348	1224.7	203.24	33.9	Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.	Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur Wheeler	N Engl J Med	2000	10793162	Yes
2295	2449	1224.5	65.03	32.5	Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering.	M P Lutolf, J A Hubbell	Nat Biotechnol	2005	15637621	No
2296	11019	1224.3	353.96	39.3	The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10.	D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C Dunbar	J Clin Psychiatry	1998	9881538	No
2297	1224	1224.0	0.0	0.0	A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon.	A M Olovnikov	J Theor Biol	1973	4754905	Yes
2298	1224	1224.0	39.27	39.3	A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation.	Ozcan Erel	Clin Biochem	2004	15003729	Yes
2299	1224	1224.0	37.63	37.6	Treatment of infections associated with surgical implants.	Rabih O Darouiche	N Engl J Med	2004	15070792	No
2300	1224	1224.0	29.65	29.6	Refined structure of the nicotinic acetylcholine receptor at 4A resolution.	Nigel Unwin	J Mol Biol	2005	15701510	Yes
2301	1224	1224.0	57.41	57.4	KDIGO clinical practice guidelines for acute kidney injury.	Arif Khwaja	Nephron Clin Pract	2012	22890468	No
2302	1223	1223.0	0.0	0.0	Disconnexion syndromes in animals and man. I.	N Geschwind	Brain	1965	5318481	No
2303	1223	1223.0	36.4	36.4	Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation.	P Willner	Psychopharmacology (Berl)	1997	9452163	No
2304	1223	1223.0	0.0	0.0	Observations on the isolated phrenic nerve diaphragm preparation of the rat.	E Bulbring	Br J Pharmacol Chemother	1946	20999334	Yes
2305	1222	1222.0	37.49	37.5	Calcium channel modulation by neurotransmitters, enzymes and drugs.	H Reuter	Nature	1983	6131381	No
2306	1222	1222.0	22.42	22.4	Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture.	H E Ruley	Nature	1983	6308473	Yes
2307	2443	1221.5	55.4	27.7	LTP and LTD: an embarrassment of riches.	Robert C Malenka, Mark F Bear	Neuron	2004	15450156	No
2308	2443	1221.5	58.35	29.2	Cellular senescence: when bad things happen to good cells.	Judith Campisi, Fabrizio d'Adda di Fagagna	Nat Rev Mol Cell Biol	2007	17667954	No
2309	1221	1221.0	30.53	30.5	The 'effective number of codons' used in a gene.	F Wright	Gene	1990	2110097	Yes
2310	1221	1221.0	0.0	0.0	Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion.	P O Seglen	Exp Cell Res	1973	4358115	Yes
2311	1221	1221.0	30.82	30.8	Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.	J Deisenhofer	Biochemistry	1981	7236608	Yes
2312	3661	1220.3	144.6	48.2	CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting.	Teresa C Horan, Mary Andrus, Margaret A Dudeck	Am J Infect Control	2008	18538699	No
2313	3661	1220.3	137.32	45.8	Global estimates of the prevalence of diabetes for 2010 and 2030.	J E Shaw, R A Sicree, P Z Zimmet	Diabetes Res Clin Pract	2010	19896746	Yes
2314	3661	1220.3	112.59	37.5	I-TASSER: a unified platform for automated protein structure and function prediction.	Ambrish Roy, Alper Kucukural, Yang Zhang	Nat Protoc	2010	20360767	Yes
2315	2440	1220.0	0.0	0.0	Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.	G K McMaster, G G Carmichael	Proc Natl Acad Sci U S A	1977	73185	Yes
2316	6100	1220.0	235.39	47.1	Evidence based medicine: what it is and what it isn't.	D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S Richardson	BMJ	1996	8555924	No
2317	1220	1220.0	40.59	40.6	An application of prefrontal cortex function theory to cognitive aging.	R L West	Psychol Bull	1996	8831298	No
2318	1220	1220.0	30.24	30.2	Proinflammatory cytokines.	C A Dinarello	Chest	2000	10936147	No
2319	1220	1220.0	32.78	32.8	Clinical features of metastatic bone disease and risk of skeletal morbidity.	Robert E Coleman	Clin Cancer Res	2006	17062708	No
2320	2439	1219.5	62.41	31.2	Interneurons of the hippocampus.	T F Freund, G Buzsáki	Hippocampus	1996	8915675	No
2321	2438	1219.0	61.95	31.0	Pharmacology and functions of metabotropic glutamate receptors.	P J Conn, J P Pin	Annu Rev Pharmacol Toxicol	1997	9131252	No
2322	1219	1219.0	42.69	42.7	Stress and disorders of the stress system.	George P Chrousos	Nat Rev Endocrinol	2009	19488073	No
2323	2437	1218.5	49.36	24.7	Prediction of complete gene structures in human genomic DNA.	C Burge, S Karlin	J Mol Biol	1997	9149143	Yes
2324	3652	1217.3	167.79	55.9	In search of how people change. Applications to addictive behaviors.	J O Prochaska, C C DiClemente, J C Norcross	Am Psychol	1992	1329589	Yes
2325	1217	1217.0	47.4	47.4	Asthma phenotypes: the evolution from clinical to molecular approaches.	Sally E Wenzel	Nat Med	2012	22561835	No
2326	1216	1216.0	0.0	0.0	A restriction point for control of normal animal cell proliferation.	A B Pardee	Proc Natl Acad Sci U S A	1974	4524638	Yes
2327	6080	1216.0	0.0	0.0	Transection of the oesophagus for bleeding oesophageal varices.	R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R Williams	Br J Surg	1973	4541913	Yes
2328	2432	1216.0	63.17	31.6	Genetic dissection of complex traits.	E S Lander, N J Schork	Science	1994	8091226	No
2329	1216	1216.0	0.0	0.0	On the psychophysical law.	S S Stevens	Psychol Rev	1957	13441853	Yes
2330	1215	1215.0	0.0	0.0	The intraclass correlation coefficient as a measure of reliability.	J J Bartko	Psychol Rep	1966	5942109	Yes
2331	1215	1215.0	37.03	37.0	Circuitry and functional aspects of the insular lobe in primates including humans.	J R Augustine	Brain Res Brain Res Rev	1996	8957561	No
2332	2430	1215.0	79.91	40.0	Porosity of 3D biomaterial scaffolds and osteogenesis.	Vassilis Karageorgiou, David Kaplan	Biomaterials	2005	15860204	No
2333	4859	1214.8	169.48	42.4	clusterProfiler: an R package for comparing biological themes among gene clusters.	Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu He	OMICS	2012	22455463	Yes
2334	2428	1214.0	0.0	0.0	High resolution acrylamide gel electrophoresis of histones.	S Panyim, R Chalkley	Arch Biochem Biophys	1969	5778650	Yes
2335	1214	1214.0	60.33	60.3	Whatever next? Predictive brains, situated agents, and the future of cognitive science.	Andy Clark	Behav Brain Sci	2013	23663408	No
2336	2427	1213.5	61.01	30.5	Molecular mechanisms of action of steroid/thyroid receptor superfamily members.	M J Tsai, B W O'Malley	Annu Rev Biochem	1994	7979245	No
2337	1213	1213.0	38.08	38.1	Classification of chronic viral hepatitis: a need for reassessment.	P J Scheuer	J Hepatol	1991	1808228	No
2338	1213	1213.0	27.06	27.1	Heterotrimeric G proteins: organizers of transmembrane signals.	E J Neer	Cell	1995	7834744	No
2339	1213	1213.0	31.44	31.4	Rapid evolution of a protein in vitro by DNA shuffling.	W P Stemmer	Nature	1994	8047147	Yes
2340	1213	1213.0	34.25	34.2	Diversity of group types, regulation, and function of phospholipase A2.	E A Dennis	J Biol Chem	1994	8175726	No
2341	1213	1213.0	24.66	24.7	Cytokines induce the development of functionally heterogeneous T helper cell subsets.	A O'Garra	Immunity	1998	9529145	No
2342	2426	1213.0	63.84	31.9	The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity.	Clay B Holroyd, Michael G H Coles	Psychol Rev	2002	12374324	Yes
2343	1213	1213.0	0.0	0.0	The critical incident technique.	J C Flanagan	Psychol Bull	1954	13177800	Yes
2344	1212	1212.0	34.01	34.0	Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections.	F Hefti	J Neurosci	1986	3746405	Yes
2345	1212	1212.0	31.01	31.0	Endothelial-leukocyte adhesion molecules.	M P Bevilacqua	Annu Rev Immunol	1993	8476577	No
2346	1212	1212.0	27.09	27.1	Maintenance of C. elegans.	Theresa Stiernagle	WormBook	2006	18050451	No
2347	1212	1212.0	54.58	54.6	Cognitive reserve in ageing and Alzheimer's disease.	Yaakov Stern	Lancet Neurol	2012	23079557	No
2348	1211	1211.0	31.19	31.2	The mitochondrial electron transport and oxidative phosphorylation system.	Y Hatefi	Annu Rev Biochem	1985	2862839	No
2349	2421	1210.5	0.0	0.0	Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies.	H A Edmondson, P E Steiner	Cancer	1954	13160935	Yes
2350	1210	1210.0	42.83	42.8	The theoretical bases of indirect calorimetry: a review.	E Ferrannini	Metabolism	1988	3278194	No
2351	1210	1210.0	0.0	0.0	The biologic clock: the mitochondria?	D Harman	J Am Geriatr Soc	1972	5016631	Yes
2352	2419	1209.5	88.43	44.2	Total energy intake: implications for epidemiologic analyses.	W Willett, M J Stampfer	Am J Epidemiol	1986	3521261	No
2353	2418	1209.0	67.54	33.8	Nitric oxide synthases: roles, tolls, and controls.	C Nathan, Q W Xie	Cell	1994	7522969	No
2354	1209	1209.0	0.0	0.0	Diversity in tropical rain forests and coral reefs.	J H Connell	Science	1978	17840770	Yes
2355	2417	1208.5	74.55	37.3	Epidemiology of invasive candidiasis: a persistent public health problem.	M A Pfaller, D J Diekema	Clin Microbiol Rev	2007	17223626	No
2356	2416	1208.0	39.36	19.7	A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback.	D Tautz, C Pfeifle	Chromosoma	1989	2476281	Yes
2357	1207	1207.0	46.48	46.5	The structure of beta-lactamases.	R P Ambler	Philos Trans R Soc Lond B Biol Sci	1980	6109327	Yes
2358	1207	1207.0	35.32	35.3	Peptide antibiotics and their role in innate immunity.	H G Boman	Annu Rev Immunol	1995	7612236	No
2359	1206	1206.0	38.24	38.2	Linkage map of Escherichia coli K-12, edition 7.	B J Bachmann	Microbiol Rev	1983	6348505	No
2360	6028	1205.6	193.27	38.7	Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.	J S Beckman, T W Beckman, J Chen, P A Marshall, B A Freeman	Proc Natl Acad Sci U S A	1990	2154753	Yes
2361	1205	1205.0	26.15	26.1	Antigen-presenting function of the macrophage.	E R Unanue	Annu Rev Immunol	1984	6242349	No
2362	1205	1205.0	28.78	28.8	Oxyradicals and DNA damage.	L J Marnett	Carcinogenesis	2000	10688856	No
2363	1205	1205.0	29.58	29.6	Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?	Rui Wang	FASEB J	2002	12409322	Yes
2364	1205	1205.0	40.82	40.8	The law of attrition.	Gunther Eysenbach	J Med Internet Res	2005	15829473	Yes
2365	2410	1205.0	65.3	32.6	The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes.	Daniel J Drucker, Michael A Nauck	Lancet	2006	17098089	No
2366	2409	1204.5	46.09	23.0	Live or let die: the cell's response to p53.	Karen H Vousden, Xin Lu	Nat Rev Cancer	2002	12154352	No
2367	3613	1204.3	97.48	32.5	Cognitive and emotional influences in anterior cingulate cortex.	Bush, Luu, Posner	Trends Cogn Sci	2000	10827444	Yes
2368	1204	1204.0	29.83	29.8	Bcl-2 initiates a new category of oncogenes: regulators of cell death.	S J Korsmeyer	Blood	1992	1498330	No
2369	1204	1204.0	55.42	55.4	Continuous improvement as an ideal in health care.	D M Berwick	N Engl J Med	1989	2909878	Yes
2370	1204	1204.0	36.42	36.4	The origins of the developmental origins theory.	D J P Barker	J Intern Med	2007	17444880	No
2371	1204	1204.0	30.83	30.8	Fast and robust fixed-point algorithms for independent component analysis.	A Hyvärinen	IEEE Trans Neural Netw	1999	18252563	Yes
2372	7223	1203.8	274.81	45.8	TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions.	Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg	Genome Biol	2013	23618408	Yes
2373	4813	1203.2	143.26	35.8	Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.	N Weidner, J P Semple, W R Welch, J Folkman	N Engl J Med	1991	1701519	Yes
2374	1203	1203.0	59.37	59.4	New norms of upper limb fat and muscle areas for assessment of nutritional status.	A R Frisancho	Am J Clin Nutr	1981	6975564	Yes
2375	1203	1203.0	21.49	21.5	The economics of ribosome biosynthesis in yeast.	J R Warner	Trends Biochem Sci	1999	10542411	No
2376	1203	1203.0	33.73	33.7	Genetic consequences of climatic oscillations in the Quaternary.	G M Hewitt	Philos Trans R Soc Lond B Biol Sci	2004	15101575	No
2377	13227	1202.5	380.11	34.6	The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.	Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J Roccella	JAMA	2003	12748199	No
2378	2405	1202.5	169.39	84.7	Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees.	Ivica Letunic, Peer Bork	Nucleic Acids Res	2016	27095192	Yes
2379	1202	1202.0	26.35	26.4	Dendritic cells: unique leukocyte populations which control the primary immune response.	D N Hart	Blood	1997	9345009	No
2380	2404	1202.0	51.86	25.9	Regulated portals of entry into the cell.	Sean D Conner, Sandra L Schmid	Nature	2003	12621426	No
2381	2404	1202.0	0.0	0.0	The Aggregation Of Blood Platelets.	G V Born, M J Cross	J Physiol	1963	14056485	Yes
2382	6009	1201.8	156.37	31.3	Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies.	Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory Collins	Lancet	2002	12493255	Yes
2383	2403	1201.5	74.49	37.2	An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat.	Sun Ho Kim, Jin Mo Chung	Pain	1992	1333581	Yes
2384	2403	1201.5	95.6	47.8	Genome editing. The new frontier of genome engineering with CRISPR-Cas9.	Jennifer A Doudna, Emmanuelle Charpentier	Science	2014	25430774	No
2385	2402	1201.0	0.0	0.0	Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty.	J M Tanner, R H Whitehouse	Arch Dis Child	1976	952550	Yes
2386	1201	1201.0	0.0	0.0	Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology.	W D Hamilton	Science	1967	6021675	Yes
2387	3603	1201.0	86.54	28.8	Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides.	Christian W Tornøe, Caspar Christensen, Morten Meldal	J Org Chem	2002	11975567	Yes
2388	1201	1201.0	22.68	22.7	SUMO: a history of modification.	Ronald T Hay	Mol Cell	2005	15808504	No
2389	2402	1201.0	59.2	29.6	Cancer stem cells in solid tumours: accumulating evidence and unresolved questions.	Jane E Visvader, Geoffrey J Lindeman	Nat Rev Cancer	2008	18784658	No
2390	2401	1200.5	61.12	30.6	The DNA damage response: making it safe to play with knives.	Alberto Ciccia, Stephen J Elledge	Mol Cell	2010	20965415	No
2391	3600	1200.0	110.39	36.8	Oxidants, antioxidants, and the degenerative diseases of aging.	B N Ames, M K Shigenaga, T M Hagen	Proc Natl Acad Sci U S A	1993	8367443	No
2392	1200	1200.0	39.07	39.1	The Neuropsychiatric Inventory: assessing psychopathology in dementia patients.	J L Cummings	Neurology	1997	9153155	No
2393	1200	1200.0	27.8	27.8	Physiological and molecular basis of thyroid hormone action.	P M Yen	Physiol Rev	2001	11427693	No
2394	1200	1200.0	0.0	0.0	The anterior approach for removal of ruptured cervical disks.	R B Cloward	J Neurosurg	1958	13599052	Yes
2395	1200	1200.0	0.0	0.0	Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.	J M Van Rossum	Arch Int Pharmacodyn Ther	1963	13996119	Yes
2396	1200	1200.0	34.89	34.9	Polycystic ovary syndrome.	David A Ehrmann	N Engl J Med	2005	15788499	No
2397	2399	1199.5	78.99	39.5	Oxidative mechanisms in the toxicity of metal ions.	S J Stohs, D Bagchi	Free Radic Biol Med	1995	7744317	No
2398	2399	1199.5	71.6	35.8	The gut microbiota shapes intestinal immune responses during health and disease.	June L Round, Sarkis K Mazmanian	Nat Rev Immunol	2009	19343057	No
2399	1199	1199.0	25.26	25.3	MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation.	R N Germain	Cell	1994	8293464	No
2400	2398	1199.0	68.41	34.2	Bronchopulmonary dysplasia.	A H Jobe, E Bancalari	Am J Respir Crit Care Med	2001	11401896	No
2401	1199	1199.0	28.38	28.4	Topoisomerase I inhibitors: camptothecins and beyond.	Yves Pommier	Nat Rev Cancer	2006	16990856	No
2402	2398	1199.0	64.56	32.3	Powering the planet: chemical challenges in solar energy utilization.	Nathan S Lewis, Daniel G Nocera	Proc Natl Acad Sci U S A	2006	17043226	Yes
2403	2396	1198.0	112.95	56.5	Natural products as sources of new drugs over the 30 years from 1981 to 2010.	David J Newman, Gordon M Cragg	J Nat Prod	2012	22316239	No
2404	1198	1198.0	43.38	43.4	Aging, cellular senescence, and cancer.	Judith Campisi	Annu Rev Physiol	2013	23140366	No
2405	2395	1197.5	71.4	35.7	Regulation of chromatin by histone modifications.	Andrew J Bannister, Tony Kouzarides	Cell Res	2011	21321607	No
2406	2395	1197.5	77.21	38.6	Genome regulation by long noncoding RNAs.	John L Rinn, Howard Y Chang	Annu Rev Biochem	2012	22663078	No
2407	1197	1197.0	35.25	35.2	Adult mesenchymal stem cells for tissue engineering versus regenerative medicine.	Arnold I Caplan	J Cell Physiol	2007	17620285	No
2408	3589	1196.3	129.31	43.1	A new method for off-line removal of ocular artifact.	G Gratton, M G Coles, E Donchin	Electroencephalogr Clin Neurophysiol	1983	6187540	Yes
2409	1196	1196.0	32.52	32.5	Low density lipoprotein oxidation and its pathobiological significance.	D Steinberg	J Biol Chem	1997	9261091	No
2410	1196	1196.0	36.33	36.3	Invasive aspergillosis.	D W Denning	Clin Infect Dis	1998	9564455	No
2411	3588	1196.0	63.99	21.3	A system for stable expression of short interfering RNAs in mammalian cells.	Thijn R Brummelkamp, René Bernards, Reuven Agami	Science	2002	11910072	Yes
2412	1196	1196.0	24.32	24.3	Mechanisms of caspase activation and inhibition during apoptosis.	Yigong Shi	Mol Cell	2002	11931755	No
2413	2392	1196.0	55.29	27.6	Escaping free-energy minima.	Alessandro Laio, Michele Parrinello	Proc Natl Acad Sci U S A	2002	12271136	Yes
2414	13154	1195.8	331.31	30.1	New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada.	P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G Gwyther	J Natl Cancer Inst	2000	10655437	No
2415	3587	1195.7	112.7	37.6	A rapid bootstrap algorithm for the RAxML Web servers.	Alexandros Stamatakis, Paul Hoover, Jacques Rougemont	Syst Biol	2008	18853362	Yes
2416	2391	1195.5	61.55	30.8	The free radical theory of aging matures.	K B Beckman, B N Ames	Physiol Rev	1998	9562038	No
2417	1195	1195.0	36.36	36.4	Qinghaosu (artemisinin): an antimalarial drug from China.	D L Klayman	Science	1985	3887571	No
2418	1195	1195.0	27.18	27.2	Hybridization of denatured RNA transferred or dotted nitrocellulose paper.	P S Thomas	Methods Enzymol	1983	6194404	Yes
2419	2390	1195.0	70.14	35.1	Molecular replacement with MOLREP.	Alexei Vagin, Alexei Teplyakov	Acta Crystallogr D Biol Crystallogr	2010	20057045	Yes
2420	2389	1194.5	0.0	0.0	Post-embryonic cell lineages of the nematode, Caenorhabditis elegans.	J E Sulston, H R Horvitz	Dev Biol	1977	838129	Yes
2421	2389	1194.5	43.91	22.0	The DNA damage response: putting checkpoints in perspective.	B B Zhou, S J Elledge	Nature	2000	11100718	No
2422	1194	1194.0	28.45	28.4	Growth factors and cancer.	S A Aaronson	Science	1991	1659742	No
2423	1194	1194.0	29.79	29.8	Hereditary cancer, oncogenes, and antioncogenes.	A G Knudson	Cancer Res	1985	2983882	Yes
2424	1194	1194.0	41.51	41.5	Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations.	Chao-Jun Li	Acc Chem Res	2009	19220064	Yes
2425	2387	1193.5	46.83	23.4	CpG islands in vertebrate genomes.	M Gardiner-Garden, M Frommer	J Mol Biol	1987	3656447	Yes
2426	1193	1193.0	59.12	59.1	ROC methodology in radiologic imaging.	C E Metz	Invest Radiol	1986	3095258	No
2427	1193	1193.0	33.46	33.5	Diagnosis of osteoporosis and assessment of fracture risk.	John A Kanis	Lancet	2002	12057569	No
2428	1193	1193.0	32.8	32.8	Marine viruses--major players in the global ecosystem.	Curtis A Suttle	Nat Rev Microbiol	2007	17853907	No
2429	1193	1193.0	41.15	41.1	Signal transduction by reactive oxygen species.	Toren Finkel	J Cell Biol	2011	21746850	No
2430	1192	1192.0	48.7	48.7	Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface.	E H Beachey	J Infect Dis	1981	7014727	No
2431	2384	1192.0	64.32	32.2	A globally coherent fingerprint of climate change impacts across natural systems.	Camille Parmesan, Gary Yohe	Nature	2003	12511946	Yes
2432	2383	1191.5	47.38	23.7	Checkpoints: controls that ensure the order of cell cycle events.	L H Hartwell, T A Weinert	Science	1989	2683079	No
2433	2383	1191.5	68.41	34.2	What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?	K C Berridge, T E Robinson	Brain Res Brain Res Rev	1998	9858756	No
2434	1191	1191.0	32.8	32.8	The human orbitofrontal cortex: linking reward to hedonic experience.	Morten L Kringelbach	Nat Rev Neurosci	2005	16136173	No
2435	1191	1191.0	28.96	29.0	Mechanisms of foxp3+ T regulatory cell-mediated suppression.	Ethan M Shevach	Immunity	2009	19464986	No
2436	1189	1189.0	45.59	45.6	UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure.	D W Russell	J Pers Assess	1996	8576833	Yes
2437	2378	1189.0	61.4	30.7	Rising incidence of hepatocellular carcinoma in the United States.	H B El-Serag, A C Mason	N Engl J Med	1999	10072408	Yes
2438	1189	1189.0	0.0	0.0	The diagnosis of ischaemic heart pain and intermittent claudication in field surveys.	G A Rose	Bull World Health Organ	1962	13974778	Yes
2439	1188	1188.0	23.72	23.7	microRNAs: tiny regulators with great potential.	V Ambros	Cell	2001	11779458	No
2440	1188	1188.0	32.9	32.9	Reconciling the chemistry and biology of reactive oxygen species.	Christine C Winterbourn	Nat Chem Biol	2008	18421291	No
2441	2375	1187.5	61.95	31.0	Neuronal plasticity: increasing the gain in pain.	C J Woolf, M W Salter	Science	2000	10846153	No
2442	2375	1187.5	54.14	27.1	The pathophysiology of mitochondrial cell death.	Douglas R Green, Guido Kroemer	Science	2004	15286356	No
2443	1187	1187.0	0.0	0.0	Campylobacter enteritis: a "new" disease.	M B Skirrow	Br Med J	1977	871765	Yes
2444	2374	1187.0	0.0	0.0	Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine.	J D Peuler, G A Johnson	Life Sci	1977	904439	Yes
2445	1187	1187.0	0.0	0.0	Assay of intestinal disaccharidases.	A Dahlqvist	Anal Biochem	1968	5636962	Yes
2446	1187	1187.0	0.0	0.0	Studies on phosphatidylcholine vesicles. Formation and physical characteristics.	C Huang	Biochemistry	1969	5777332	Yes
2447	2374	1187.0	64.31	32.2	Leukocyte-endothelial adhesion molecules.	T M Carlos, J M Harlan	Blood	1994	7522621	No
2448	1187	1187.0	26.26	26.3	The finer things in X-ray diffraction data collection.	J W Pflugrath	Acta Crystallogr D Biol Crystallogr	1999	10531521	Yes
2449	1187	1187.0	27.3	27.3	The stem-cell niche as an entity of action.	David T Scadden	Nature	2006	16810242	No
2450	2373	1186.5	75.19	37.6	CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure.	Mattias Jakobsson, Noah A Rosenberg	Bioinformatics	2007	17485429	Yes
2451	2373	1186.5	65.28	32.6	Cell signaling by receptor tyrosine kinases.	Mark A Lemmon, Joseph Schlessinger	Cell	2010	20602996	No
2452	3559	1186.3	88.72	29.6	Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?	Witold Filipowicz, Suvendra N Bhattacharyya, Nahum Sonenberg	Nat Rev Genet	2008	18197166	No
2453	2372	1186.0	79.51	39.8	Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art.	Johan W S Vlaeyen, Steven J Linton	Pain	2000	10781906	No
2454	1186	1186.0	40.07	40.1	Chlorophyll fluorescence: a probe of photosynthesis in vivo.	Neil R Baker	Annu Rev Plant Biol	2008	18444897	No
2455	1185	1185.0	47.13	47.1	Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models.	T Florian Jaeger	J Mem Lang	2008	19884961	Yes
2456	4736	1184.0	217.53	54.4	Bayesian phylogenetics with BEAUti and the BEAST 1.7.	Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew Rambaut	Mol Biol Evol	2012	22367748	Yes
2457	2368	1184.0	67.67	33.8	The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin.	W L Jorgensen, J Tirado-Rives	J Am Chem Soc	1988	27557051	Yes
2458	1183	1183.0	45.28	45.3	Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment.	S H Safe	Crit Rev Toxicol	1994	8037844	No
2459	1183	1183.0	29.42	29.4	Somatostatin and its receptor family.	Y C Patel	Front Neuroendocrinol	1999	10433861	No
2460	1183	1183.0	29.17	29.2	Reactive oxygen radicals in signaling and damage in the ischemic brain.	P H Chan	J Cereb Blood Flow Metab	2001	11149664	No
2461	2365	1182.5	54.7	27.4	Transforming gene product of Rous sarcoma virus phosphorylates tyrosine.	T Hunter, B M Sefton	Proc Natl Acad Sci U S A	1980	6246487	Yes
2462	4730	1182.5	113.17	28.3	Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.	Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J Thun	N Engl J Med	2003	12711737	Yes
2463	1182	1182.0	28.75	28.8	Intracellular protein topogenesis.	G Blobel	Proc Natl Acad Sci U S A	1980	6929499	Yes
2464	1182	1182.0	0.0	0.0	The Colorimetric Micro-Determination Of Non-Esterified Fatty Acids In Plasma.	W G Duncombe	Clin Chim Acta	1964	14122498	Yes
2465	2363	1181.5	0.0	0.0	Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats.	J Altman, G D Das	J Comp Neurol	1965	5861717	Yes
2466	2363	1181.5	45.2	22.6	DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.	Christopher J Bakkenist, Michael B Kastan	Nature	2003	12556884	Yes
2467	1181	1181.0	43.39	43.4	Transduction of psychosocial stress into the neurobiology of recurrent affective disorder.	R M Post	Am J Psychiatry	1992	1353322	No
2468	1181	1181.0	0.0	0.0	The cytoarchitectonic organization of the spinal cord in the cat.	B Rexed	J Comp Neurol	1952	14946260	Yes
2469	8263	1180.4	346.03	49.4	Development and validation of a geriatric depression screening scale: a preliminary report.	J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O Leirer	J Psychiatr Res	1982	7183759	Yes
2470	2360	1180.0	0.0	0.0	Surgical risk as related to time of intervention in the repair of intracranial aneurysms.	W E Hunt, R M Hess	J Neurosurg	1968	5635959	Yes
2471	2360	1180.0	64.06	32.0	Nanostructures in biodiagnostics.	Nathaniel L Rosi, Chad A Mirkin	Chem Rev	2005	15826019	No
2472	2360	1180.0	94.23	47.1	The integrative review: updated methodology.	Robin Whittemore, Kathleen Knafl	J Adv Nurs	2005	16268861	Yes
2473	3537	1179.0	91.51	30.5	Long non-coding RNAs: insights into functions.	Tim R Mercer, Marcel E Dinger, John S Mattick	Nat Rev Genet	2009	19188922	No
2474	1178	1178.0	38.0	38.0	The pathogenesis of sepsis.	R C Bone	Ann Intern Med	1991	1872494	No
2475	2356	1178.0	0.0	0.0	Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.	R W Butcher, E W Sutherland	J Biol Chem	1962	13875173	Yes
2476	1178	1178.0	38.45	38.5	Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?	Thomas Grobner	Nephrol Dial Transplant	2006	16431890	Yes
2477	2355	1177.5	64.8	32.4	Therapeutic potential of resveratrol: the in vivo evidence.	Joseph A Baur, David A Sinclair	Nat Rev Drug Discov	2006	16732220	No
2478	2355	1177.5	75.65	37.8	The cortical organization of speech processing.	Gregory Hickok, David Poeppel	Nat Rev Neurosci	2007	17431404	No
2479	1177	1177.0	25.27	25.3	Caspase structure, proteolytic substrates, and function during apoptotic cell death.	D W Nicholson	Cell Death Differ	1999	10578171	No
2480	2354	1177.0	49.18	24.6	Gene silencing in cancer in association with promoter hypermethylation.	James G Herman, Stephen B Baylin	N Engl J Med	2003	14627790	No
2481	1177	1177.0	34.51	34.5	Stress and depression.	Constance Hammen	Annu Rev Clin Psychol	2005	17716090	No
2482	16470	1176.4	365.62	26.1	Crystallography & NMR system: A new software suite for macromolecular structure determination.	A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L Warren	Acta Crystallogr D Biol Crystallogr	1998	9757107	Yes
2483	7054	1175.7	185.81	31.0	A default mode of brain function.	M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L Shulman	Proc Natl Acad Sci U S A	2001	11209064	Yes
2484	1175	1175.0	34.95	35.0	Atopic dermatitis.	Thomas Bieber	N Engl J Med	2008	18385500	Yes
2485	1174	1174.0	30.52	30.5	Surrogate endpoints in clinical trials: definition and operational criteria.	R L Prentice	Stat Med	1989	2727467	Yes
2486	1174	1174.0	39.79	39.8	Interleukin-1 and the pathogenesis of the acute-phase response.	C A Dinarello	N Engl J Med	1984	6208485	No
2487	3522	1174.0	88.53	29.5	Thresholding of statistical maps in functional neuroimaging using the false discovery rate.	Christopher R Genovese, Nicole A Lazar, Thomas Nichols	Neuroimage	2002	11906227	Yes
2488	2348	1174.0	73.45	36.7	Mediation in experimental and nonexperimental studies: new procedures and recommendations.	Patrick E Shrout, Niall Bolger	Psychol Methods	2002	12530702	Yes
2489	1174	1174.0	34.08	34.1	The cancer stem cell: premises, promises and challenges.	Hans Clevers	Nat Med	2011	21386835	No
2490	1174	1174.0	45.69	45.7	Inflammation in atherosclerosis.	Peter Libby	Arterioscler Thromb Vasc Biol	2012	22895665	No
2491	2347	1173.5	56.85	28.4	Peroxisome proliferator-activated receptors: nuclear control of metabolism.	B Desvergne, W Wahli	Endocr Rev	1999	10529898	No
2492	1173	1173.0	29.89	29.9	The neuropathology of schizophrenia. A critical review of the data and their interpretation.	P J Harrison	Brain	1999	10219775	No
2493	2346	1173.0	82.36	41.2	Oxidative stress and diabetic complications.	Ferdinando Giacco, Michael Brownlee	Circ Res	2010	21030723	No
2494	1172	1172.0	55.9	55.9	A cognitive approach to panic.	D M Clark	Behav Res Ther	1986	3741311	Yes
2495	1172	1172.0	0.0	0.0	Displaced proximal humeral fractures. I. Classification and evaluation.	C S Neer	J Bone Joint Surg Am	1970	5455339	Yes
2496	1172	1172.0	24.55	24.6	Morphogenetic roles of classic cadherins.	M Takeichi	Curr Opin Cell Biol	1995	8573335	No
2497	2344	1172.0	45.57	22.8	The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.	T Maehama, J E Dixon	J Biol Chem	1998	9593664	Yes
2498	1172	1172.0	0.0	0.0	A sensitive method for the assay of 5-hydroxytryptamine.	J R Vane	Br J Pharmacol Chemother	1957	13460242	Yes
2499	1171	1171.0	0.0	0.0	A chemical method for the determination of oestriol, oestrone and oestradiol in human urine.	J B Brown	Biochem J	1955	14389222	Yes
2500	1171	1171.0	0.0	0.0	Histological demonstration of mucin after periodic acid.	J F A McMANUS	Nature	1946	20995486	Yes
2501	1170	1170.0	21.22	21.2	Cancer susceptibility and the functions of BRCA1 and BRCA2.	Ashok R Venkitaraman	Cell	2002	11832208	No
2502	1170	1170.0	0.0	0.0	A new readability yardstick.	R Flesch	J Appl Psychol	1948	18867058	Yes
2503	2339	1169.5	74.1	37.0	Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India.	D Filmer, L H Pritchett	Demography	2001	11227840	Yes
2504	1169	1169.0	0.0	0.0	Nontuberculous mycobacteria and associated diseases.	E Wolinsky	Am Rev Respir Dis	1979	369415	No
2505	1169	1169.0	36.17	36.2	The mysteries of lipoprotein(a).	G Utermann	Science	1989	2530631	No
2506	1169	1169.0	40.81	40.8	The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension.	N M Kaplan	Arch Intern Med	1989	2662932	No
2507	1169	1169.0	65.87	65.9	Psychosocial resilience and protective mechanisms.	Michael Rutter	Am J Orthopsychiatry	1987	3303954	No
2508	3507	1169.0	85.03	28.3	Dystrophin: the protein product of the Duchenne muscular dystrophy locus.	E P Hoffman, R H Brown, L M Kunkel	Cell	1987	3319190	Yes
2509	1169	1169.0	34.82	34.8	Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes.	W Sieghart	Pharmacol Rev	1995	7568326	No
2510	2337	1168.5	119.03	59.5	A new initiative on precision medicine.	Francis S Collins, Harold Varmus	N Engl J Med	2015	25635347	Yes
2511	1168	1168.0	36.71	36.7	Biosynthesis and metabolism of endothelium-derived nitric oxide.	L J Ignarro	Annu Rev Pharmacol Toxicol	1990	2188578	No
2512	1168	1168.0	26.01	26.0	The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression.	S J Collins	Blood	1987	3311197	No
2513	1168	1168.0	31.34	31.3	Drug delivery and targeting.	R Langer	Nature	1998	9579855	No
2514	1168	1168.0	28.9	28.9	The path to ubiquitous and low-cost organic electronic appliances on plastic.	Stephen R Forrest	Nature	2004	15118718	Yes
2515	3502	1167.3	102.53	34.2	Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections.	H King, R E Aubert, W H Herman	Diabetes Care	1998	9727886	Yes
2516	1167	1167.0	37.57	37.6	Antioxidants in human health and disease.	B Halliwell	Annu Rev Nutr	1996	8839918	No
2517	3501	1167.0	74.14	24.7	Large-scale analysis of the yeast proteome by multidimensional protein identification technology.	M P Washburn, D Wolters, J R Yates	Nat Biotechnol	2001	11231557	Yes
2518	1167	1167.0	32.45	32.5	Plasmonics: merging photonics and electronics at nanoscale dimensions.	Ekmel Ozbay	Science	2006	16410515	Yes
2519	1167	1167.0	36.45	36.5	Multiple imputation of discrete and continuous data by fully conditional specification.	Stef van Buuren	Stat Methods Med Res	2007	17621469	Yes
2520	1167	1167.0	33.02	33.0	Microbial influences in inflammatory bowel diseases.	R Balfour Sartor	Gastroenterology	2008	18242222	No
2521	2333	1166.5	68.62	34.3	Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies.	Robert E W Hancock, Hans-Georg Sahl	Nat Biotechnol	2006	17160061	No
2522	3499	1166.3	86.18	28.7	Global and societal implications of the diabetes epidemic.	P Zimmet, K G Alberti, J Shaw	Nature	2001	11742409	No
2523	1166	1166.0	0.0	0.0	Measurement of feelings using visual analogue scales.	R C Aitken	Proc R Soc Med	1969	4899510	No
2524	1166	1166.0	42.44	42.4	Multimodal approach to control postoperative pathophysiology and rehabilitation.	H Kehlet	Br J Anaesth	1997	9175983	No
2525	1166	1166.0	52.97	53.0	MorphoJ: an integrated software package for geometric morphometrics.	Christian Peter Klingenberg	Mol Ecol Resour	2011	21429143	Yes
2526	10491	1165.7	357.76	39.8	A novel potent vasoconstrictor peptide produced by vascular endothelial cells.	M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T Masaki	Nature	1988	2451132	Yes
2527	3497	1165.7	86.66	28.9	Functional diversity of helper T lymphocytes.	A K Abbas, K M Murphy, A Sher	Nature	1996	8893001	No
2528	3496	1165.3	0.0	0.0	Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.	A DeLean, P J Munson, D Rodbard	Am J Physiol	1978	686171	Yes
2529	2330	1165.0	0.0	0.0	The low-density lipoprotein pathway and its relation to atherosclerosis.	J L Goldstein, M S Brown	Annu Rev Biochem	1977	197883	No
2530	1165	1165.0	44.5	44.5	A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes.	S T Tiffany	Psychol Rev	1990	2186423	No
2531	5822	1164.4	191.77	38.4	Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity.	D Steinberg, S Parthasarathy, T E Carew, J C Khoo, J L Witztum	N Engl J Med	1989	2648148	No
2532	2328	1164.0	122.25	61.1	A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain.	M Roland, R Morris	Spine (Phila Pa 1976)	1983	6222486	Yes
2533	1164	1164.0	29.08	29.1	Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase.	P Kuzmic	Anal Biochem	1996	8660575	Yes
2534	1164	1164.0	21.99	22.0	Kinesin and dynein superfamily proteins and the mechanism of organelle transport.	N Hirokawa	Science	1998	9438838	No
2535	1164	1164.0	26.57	26.6	S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles.	R Donato	Int J Biochem Cell Biol	2001	11390274	No
2536	2328	1164.0	74.09	37.0	The benefits of being present: mindfulness and its role in psychological well-being.	Kirk Warren Brown, Richard M Ryan	J Pers Soc Psychol	2003	12703651	Yes
2537	1164	1164.0	28.43	28.4	Oxidative stress in neurodegeneration: cause or consequence?	Julie K Andersen	Nat Med	2004	15298006	No
2538	1163	1163.0	0.0	0.0	Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation.	M M Weiser	J Biol Chem	1973	4698230	Yes
2539	1163	1163.0	52.61	52.6	Presynaptic regulation of the release of catecholamines.	S Z Langer	Pharmacol Rev	1980	6267618	Yes
2540	1163	1163.0	21.74	21.7	The molecular motor toolbox for intracellular transport.	Ronald D Vale	Cell	2003	12600311	No
2541	1162	1162.0	26.39	26.4	Prediction of protein cellular attributes using pseudo-amino acid composition.	K C Chou	Proteins	2001	11288174	Yes
2542	3485	1161.7	105.41	35.1	The functional anatomy of basal ganglia disorders.	R L Albin, A B Young, J B Penney	Trends Neurosci	1989	2479133	No
2543	2323	1161.5	95.02	47.5	Rapid procedure for detection and isolation of large and small plasmids.	C I Kado, S T Liu	J Bacteriol	1981	7009583	Yes
2544	2323	1161.5	86.65	43.3	How useful is SBF in predicting in vivo bone bioactivity?	Tadashi Kokubo, Hiroaki Takadama	Biomaterials	2006	16448693	No
2545	3484	1161.3	0.0	0.0	Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels.	A L Shapiro, E Viñuela, J V Maizel	Biochem Biophys Res Commun	1967	4861258	Yes
2546	4645	1161.2	110.02	27.5	A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.	Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry Sharpless	Angew Chem Int Ed Engl	2002	12203546	Yes
2547	1161	1161.0	49.37	49.4	Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs).	S Safe	Crit Rev Toxicol	1990	2124811	No
2548	1161	1161.0	26.9	26.9	Nuclear factor-kappaB: the enemy within.	Bharat B Aggarwal	Cancer Cell	2004	15380510	No
2549	2322	1161.0	187.89	93.9	Natural Products as Sources of New Drugs from 1981 to 2014.	David J Newman, Gordon M Cragg	J Nat Prod	2016	26852623	No
2550	2321	1160.5	63.71	31.9	Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications.	M A Pfeffer, E Braunwald	Circulation	1990	2138525	No
2551	2321	1160.5	63.99	32.0	A review of central 5-HT receptors and their function.	N M Barnes, T Sharp	Neuropharmacology	1999	10462127	No
2552	1160	1160.0	61.74	61.7	Rating scales to assess depression in school-aged children.	M Kovacs	Acta Paedopsychiatr	1981	7025571	Yes
2553	1160	1160.0	19.76	19.8	Themes and variations on ubiquitylation.	A M Weissman	Nat Rev Mol Cell Biol	2001	11265246	No
2554	1160	1160.0	0.0	0.0	Diffusion-in-gel methods for immunological analysis. II.	O Ouchterlony	Prog Allergy	1962	14482809	Yes
2555	3478	1159.3	121.84	40.6	Factor structure of the Barratt impulsiveness scale.	J H Patton, M S Stanford, E S Barratt	J Clin Psychol	1995	8778124	Yes
2556	1159	1159.0	0.0	0.0	Mutation selection and the natural history of cancer.	J Cairns	Nature	1975	1143315	Yes
2557	1159	1159.0	74.36	74.4	Impingement lesions.	C S Neer	Clin Orthop Relat Res	1983	6825348	Yes
2558	1159	1159.0	27.48	27.5	Transcriptional control of adipocyte formation.	Stephen R Farmer	Cell Metab	2006	17011499	No
2559	1158	1158.0	0.0	0.0	Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle.	J O Holloszy	J Biol Chem	1967	4290225	Yes
2560	1158	1158.0	23.07	23.1	Mobile elements: drivers of genome evolution.	Haig H Kazazian	Science	2004	15016989	No
2561	1158	1158.0	30.09	30.1	The blood-brain barrier: bottleneck in brain drug development.	William M Pardridge	NeuroRx	2005	15717053	No
2562	6945	1157.5	178.45	29.7	GROMACS: fast, flexible, and free.	David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C Berendsen	J Comput Chem	2005	16211538	Yes
2563	1157	1157.0	22.11	22.1	Contingent genetic regulatory events in T lymphocyte activation.	G R Crabtree	Science	1989	2783497	Yes
2564	1157	1157.0	0.0	0.0	Presynaptic regulation of catecholamine release.	S Z Langer	Biochem Pharmacol	1974	4617579	No
2565	1157	1157.0	36.24	36.2	Depression in late life: review and commentary.	Dan G Blazer	J Gerontol A Biol Sci Med Sci	2003	12634292	No
2566	3471	1157.0	90.67	30.2	Functional porous coordination polymers.	Susumu Kitagawa, Ryo Kitaura, Shin-ichiro Noro	Angew Chem Int Ed Engl	2004	15114565	Yes
2567	1157	1157.0	0.0	0.0	An approximate distribution of estimates of variance components.	F E Satterthwaite	Biometrics	1946	20287815	Yes
2568	2313	1156.5	50.53	25.3	ERBB receptors and cancer: the complexity of targeted inhibitors.	Nancy E Hynes, Heidi A Lane	Nat Rev Cancer	2005	15864276	No
2569	5782	1156.4	787.15	157.4	MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms.	Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro Tamura	Mol Biol Evol	2018	29722887	Yes
2570	1156	1156.0	52.54	52.5	Human agency in social cognitive theory.	A Bandura	Am Psychol	1989	2782727	Yes
2571	1156	1156.0	22.51	22.5	Histone-deacetylase inhibitors: novel drugs for the treatment of cancer.	Ricky W Johnstone	Nat Rev Drug Discov	2002	12120280	No
2572	1156	1156.0	33.23	33.2	Emotion regulation: affective, cognitive, and social consequences.	James J Gross	Psychophysiology	2002	12212647	No
2573	1156	1156.0	37.05	37.0	Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES).	Gunther Eysenbach	J Med Internet Res	2004	15471760	No
2574	9244	1155.5	242.69	30.3	Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain.	N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M Joliot	Neuroimage	2002	11771995	Yes
2575	4621	1155.2	99.41	24.9	Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.	D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini	Science	2005	15718470	Yes
2576	3463	1154.3	72.56	24.2	Cellular survival: a play in three Akts.	S R Datta, A Brunet, M E Greenberg	Genes Dev	1999	10579998	No
2577	1154	1154.0	0.0	0.0	RNA metabolism in the HeLa cell nucleus.	S Penman	J Mol Biol	1966	5961144	Yes
2578	6922	1153.7	136.07	22.7	Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.	S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T Tuschl	Nature	2001	11373684	Yes
2579	2307	1153.5	0.0	0.0	Plasminogen: purification from human plasma by affinity chromatography.	D G Deutsch, E T Mertz	Science	1970	5475635	Yes
2580	1153	1153.0	45.21	45.2	Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes.	H V Gelboin	Physiol Rev	1980	7001511	No
2581	1153	1153.0	27.73	27.7	Liver fibrosis -- from bench to bedside.	Scott L Friedman	J Hepatol	2003	12591185	No
2582	3456	1152.0	0.0	0.0	High resolution two-dimensional electrophoresis of basic as well as acidic proteins.	P Z O'Farrell, H M Goodman, P H O'Farrell	Cell	1977	23215	Yes
2583	1152	1152.0	46.9	46.9	An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results.	J Kabat-Zinn	Gen Hosp Psychiatry	1982	7042457	Yes
2584	2303	1151.5	0.0	0.0	Quantitative determination of serum triglycerides by the use of enzymes.	G Bucolo, H David	Clin Chem	1973	4703655	Yes
2585	2303	1151.5	59.52	29.8	Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits.	Kornelia Polyak, Robert A Weinberg	Nat Rev Cancer	2009	19262571	No
2586	2302	1151.0	45.33	22.7	Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.	C W Greider, E H Blackburn	Cell	1985	3907856	Yes
2587	1151	1151.0	40.94	40.9	Inhibition and facilitation of nucleic acid amplification.	I G Wilson	Appl Environ Microbiol	1997	9327537	No
2588	1151	1151.0	60.97	61.0	Optical properties of biological tissues: a review.	Steven L Jacques	Phys Med Biol	2013	23666068	No
2589	1151	1151.0	57.44	57.4	Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement.	Virginia A Moyer	Ann Intern Med	2014	24378917	No
2590	1150	1150.0	53.98	54.0	Biomaterial-centered infection: microbial adhesion versus tissue integration.	A G Gristina	Science	1987	3629258	Yes
2591	3450	1150.0	0.0	0.0	The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects.	G Blessed, B E Tomlinson, M Roth	Br J Psychiatry	1968	5662937	Yes
2592	1150	1150.0	0.0	0.0	Selective coronary arteriography. I. A percutaneous transfemoral technic.	M P Judkins	Radiology	1967	6048074	Yes
2593	2300	1150.0	51.42	25.7	Lymphocyte homing and homeostasis.	E C Butcher, L J Picker	Science	1996	8600538	No
2594	2299	1149.5	62.91	31.5	Imaging cognition II: An empirical review of 275 PET and fMRI studies.	R Cabeza, L Nyberg	J Cogn Neurosci	2000	10769304	No
2595	3448	1149.3	96.44	32.1	Molecular characterization of a peripheral receptor for cannabinoids.	S Munro, K L Thomas, M Abu-Shaar	Nature	1993	7689702	Yes
2596	1149	1149.0	28.13	28.1	Matrix proteoglycans: from molecular design to cellular function.	R V Iozzo	Annu Rev Biochem	1998	9759499	No
2597	1149	1149.0	33.85	33.9	Varieties of impulsivity.	J L Evenden	Psychopharmacology (Berl)	1999	10550486	No
2598	2298	1149.0	47.69	23.8	Molecular chaperones in the cytosol: from nascent chain to folded protein.	F Ulrich Hartl, Manajit Hayer-Hartl	Science	2002	11884745	No
2599	1149	1149.0	33.36	33.4	The sympathetic control of blood pressure.	Patrice G Guyenet	Nat Rev Neurosci	2006	16760914	No
2600	1149	1149.0	0.0	0.0	A microchemical reaction resulting in the staining of polysaccharide structures in fixed tissue preparations.	R D Hotchkiss	Arch Biochem	1948	18921848	Yes
2601	1148	1148.0	25.89	25.9	Cadherins: a molecular family important in selective cell-cell adhesion.	M Takeichi	Annu Rev Biochem	1990	2197976	No
2602	1148	1148.0	30.67	30.7	Pathogenesis of dengue: challenges to molecular biology.	S B Halstead	Science	1988	3277268	No
2603	1148	1148.0	31.14	31.1	The lipocalin protein family: structure and function.	D R Flower	Biochem J	1996	8761444	No
2604	1148	1148.0	23.41	23.4	Lipid rafts: elusive or illusive?	Sean Munro	Cell	2003	14622593	No
2605	1148	1148.0	26.68	26.7	Long-term potentiation and memory.	M A Lynch	Physiol Rev	2004	14715912	No
2606	5737	1147.4	111.82	22.4	Crystal structure of the nucleosome core particle at 2.8 A resolution.	K Luger, A W Mäder, R K Richmond, D F Sargent, T J Richmond	Nature	1997	9305837	Yes
2607	1147	1147.0	53.42	53.4	Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters.	P de Leva	J Biomech	1996	8872282	Yes
2608	1147	1147.0	30.14	30.1	Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.	G Boden	Diabetes	1997	8971073	No
2609	2294	1147.0	65.45	32.7	Antibiotic resistance of bacteria in biofilms.	P S Stewart, J W Costerton	Lancet	2001	11463434	No
2610	2294	1147.0	50.11	25.1	Tumorigenesis and the angiogenic switch.	Gabriele Bergers, Laura E Benjamin	Nat Rev Cancer	2003	12778130	No
2611	1146	1146.0	58.98	59.0	The clinical application of the biopsychosocial model.	G L Engel	Am J Psychiatry	1980	7369396	Yes
2612	1146	1146.0	27.89	27.9	DNA damage, aging, and cancer.	Jan H J Hoeijmakers	N Engl J Med	2009	19812404	No
2613	3436	1145.3	116.32	38.8	Simultaneous inference in general parametric models.	Torsten Hothorn, Frank Bretz, Peter Westfall	Biom J	2008	18481363	No
2614	1145	1145.0	0.0	0.0	Radioimmunological determination of human C-peptide in serum.	L G Heding	Diabetologia	1975	1239396	Yes
2615	1145	1145.0	0.0	0.0	Biogenic amines and the states of sleep.	M Jouvet	Science	1969	4303225	No
2616	1144	1144.0	0.0	0.0	Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol.	D B Clewell	J Bacteriol	1972	4336693	Yes
2617	2288	1144.0	63.93	32.0	ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins.	Markus Wiederstein, Manfred J Sippl	Nucleic Acids Res	2007	17517781	Yes
2618	2287	1143.5	0.0	0.0	Growth of a rat neuroblastoma cell line in serum-free supplemented medium.	J E Bottenstein, G H Sato	Proc Natl Acad Sci U S A	1979	284369	Yes
2619	3430	1143.3	75.0	25.0	Calcium signalling: dynamics, homeostasis and remodelling.	Michael J Berridge, Martin D Bootman, H Llewelyn Roderick	Nat Rev Mol Cell Biol	2003	12838335	No
2620	2286	1143.0	69.76	34.9	Recent advances in the phencyclidine model of schizophrenia.	D C Javitt, S R Zukin	Am J Psychiatry	1991	1654746	No
2621	1143	1143.0	21.0	21.0	Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes.	D Hanahan	Nature	1985	2986015	Yes
2622	1143	1143.0	32.33	32.3	DNA topoisomerases.	M Gellert	Annu Rev Biochem	1981	6267993	No
2623	1143	1143.0	29.29	29.3	Optimal experimental design for event-related fMRI.	A M Dale	Hum Brain Mapp	1999	10524601	Yes
2624	2285	1142.5	61.45	30.7	Regulation mechanisms and signaling pathways of autophagy.	Congcong He, Daniel J Klionsky	Annu Rev Genet	2009	19653858	No
2625	2284	1142.0	0.0	0.0	Solubilization of membranes by detergents.	A Helenius, K Simons	Biochim Biophys Acta	1975	1091302	No
2626	1142	1142.0	33.43	33.4	Papillary and follicular thyroid carcinoma.	M J Schlumberger	N Engl J Med	1998	9445411	No
2627	3423	1141.0	0.0	0.0	Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.	G M Wahl, M Stern, G R Stark	Proc Natl Acad Sci U S A	1979	291033	Yes
2628	2282	1141.0	46.66	23.3	A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells.	N C Andrews, D V Faller	Nucleic Acids Res	1991	2041787	Yes
2629	2282	1141.0	62.66	31.3	Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.	R A Ignotz, J Massagué	J Biol Chem	1986	3456347	Yes
2630	1140	1140.0	0.0	0.0	Experience from a multicentre stroke register: a preliminary report.	S Hatano	Bull World Health Organ	1976	1088404	Yes
2631	1140	1140.0	0.0	0.0	pA, a new scale for the measurement of drug antagonism.	H O Schild	Br J Pharmacol Chemother	1947	20258355	Yes
2632	1139	1139.0	30.69	30.7	Psychological and neural mechanisms of the affective dimension of pain.	D D Price	Science	2000	10846154	No
2633	1139	1139.0	25.0	25.0	Platelets in atherothrombosis.	Zaverio M Ruggeri	Nat Med	2002	12411949	No
2634	1138	1138.0	35.79	35.8	Protein damage and degradation by oxygen radicals. I. general aspects.	K J Davies	J Biol Chem	1987	3036875	Yes
2635	1138	1138.0	31.61	31.6	Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena.	U Mitzdorf	Physiol Rev	1985	3880898	No
2636	1138	1138.0	45.17	45.2	Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living.	S Katz	J Am Geriatr Soc	1983	6418786	No
2637	1138	1138.0	0.0	0.0	Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase.	R J Pennington	Biochem J	1961	13734134	Yes
2638	2276	1138.0	54.36	27.2	Can the pharmaceutical industry reduce attrition rates?	Ismail Kola, John Landis	Nat Rev Drug Discov	2004	15286737	No
2639	3413	1137.7	87.97	29.3	LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions.	A C Wallace, R A Laskowski, J M Thornton	Protein Eng	1995	7630882	Yes
2640	2275	1137.5	0.0	0.0	Radiological demarcation of cemented sockets in total hip replacement.	J G DeLee, J Charnley	Clin Orthop Relat Res	1976	991504	Yes
2641	3412	1137.3	0.0	0.0	Cytochemical identification of monocytes and granulocytes.	L T Yam, C Y Li, W H Crosby	Am J Clin Pathol	1971	5549896	Yes
2642	1137	1137.0	0.0	0.0	Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release.	S Z Langer	Br J Pharmacol	1977	20190	No
2643	1137	1137.0	27.67	27.7	Rapid and sensitive sequence comparison with FASTP and FASTA.	W R Pearson	Methods Enzymol	1990	2156132	Yes
2644	1137	1137.0	28.95	28.9	Two distinct classes of carbohydrate-recognition domains in animal lectins.	K Drickamer	J Biol Chem	1988	3290208	No
2645	1137	1137.0	0.0	0.0	The concept of immunological surveillance.	F M Burnet	Prog Exp Tumor Res	1970	4921480	No
2646	1137	1137.0	0.0	0.0	Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells.	A B Stavitsky	J Immunol	1954	13163409	Yes
2647	1137	1137.0	0.0	0.0	A simple objective technique for measuring flexibility in thinking.	E A Berg	J Gen Psychol	1948	18889466	Yes
2648	3410	1136.7	93.38	31.1	Membrane lipids: where they are and how they behave.	Gerrit van Meer, Dennis R Voelker, Gerald W Feigenson	Nat Rev Mol Cell Biol	2008	18216768	No
2649	6818	1136.3	175.27	29.2	Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.	Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O Lötvall	Nat Cell Biol	2007	17486113	Yes
2650	2272	1136.0	89.08	44.5	Malondialdehyde determination as index of lipid peroxidation.	H H Draper, M Hadley	Methods Enzymol	1990	2233309	Yes
2651	1136	1136.0	34.41	34.4	Effect of anoxia on ion distribution in the brain.	A J Hansen	Physiol Rev	1985	3880896	No
2652	1136	1136.0	0.0	0.0	Pathologic anatomy of the pancreas in juvenile diabetes mellitus.	W Gepts	Diabetes	1965	5318831	Yes
2653	1136	1136.0	0.0	0.0	An improved fluorometric assay for DNA.	R T Hinegardner	Anal Biochem	1971	5544593	Yes
2654	1136	1136.0	54.09	54.1	Selenium and human health.	Margaret P Rayman	Lancet	2012	22381456	No
2655	3406	1135.3	89.46	29.8	Atomic force microscope.	Binnig, Quate, Gerber	Phys Rev Lett	1986	10033323	Yes
2656	2269	1134.5	60.81	30.4	Microglia: active sensor and versatile effector cells in the normal and pathologic brain.	Uwe-Karsten Hanisch, Helmut Kettenmann	Nat Neurosci	2007	17965659	No
2657	2268	1134.0	49.73	24.9	Functions of lipid rafts in biological membranes.	D A Brown, E London	Annu Rev Cell Dev Biol	1998	9891780	No
2658	1134	1134.0	26.83	26.8	Mitochondrial transport of cations: channels, exchangers, and permeability transition.	P Bernardi	Physiol Rev	1999	10508231	No
2659	4536	1134.0	100.33	25.1	Interleukin-10 and the interleukin-10 receptor.	K W Moore, R de Waal Malefyt, R L Coffman, A O'Garra	Annu Rev Immunol	2001	11244051	No
2660	1134	1134.0	29.02	29.0	Primate anterior cingulate cortex: where motor control, drive and cognition interface.	T Paus	Nat Rev Neurosci	2001	11389475	No
2661	1134	1134.0	38.11	38.1	The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases.	Artemis P Simopoulos	Exp Biol Med (Maywood)	2008	18408140	No
2662	2267	1133.5	95.85	47.9	Reading senseless sentences: brain potentials reflect semantic incongruity.	M Kutas, S A Hillyard	Science	1980	7350657	Yes
2663	2266	1133.0	71.43	35.7	Role of oxidized low density lipoprotein in atherogenesis.	J L Witztum, D Steinberg	J Clin Invest	1991	1752940	No
2664	1133	1133.0	0.0	0.0	Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone.	A R Midgley	Endocrinology	1966	5950482	Yes
2665	1133	1133.0	36.96	37.0	Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology.	J J Gross	J Pers Soc Psychol	1998	9457784	Yes
2666	1133	1133.0	26.45	26.4	Diarylethenes for Memories and Switches.	Masahiro Irie	Chem Rev	2000	11777416	Yes
2667	1133	1133.0	27.89	27.9	Pathways of oxidative damage.	James A Imlay	Annu Rev Microbiol	2003	14527285	No
2668	1133	1133.0	27.32	27.3	The Unified Medical Language System (UMLS): integrating biomedical terminology.	Olivier Bodenreider	Nucleic Acids Res	2004	14681409	Yes
2669	2265	1132.5	64.8	32.4	Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.	Ajay Kumar Gupta, Mona Gupta	Biomaterials	2005	15626447	No
2670	2264	1132.0	61.83	30.9	Myocardial reperfusion injury.	Derek M Yellon, Derek J Hausenloy	N Engl J Med	2007	17855673	No
2671	1131	1131.0	52.53	52.5	Derivation and validation of a short-form oral health impact profile.	G D Slade	Community Dent Oral Epidemiol	1997	9332805	Yes
2672	1131	1131.0	22.39	22.4	Mechanisms and consequences of activation of protein kinase B/Akt.	J Downward	Curr Opin Cell Biol	1998	9561851	No
2673	1131	1131.0	26.11	26.1	Translating cell biology into therapeutic advances in Alzheimer's disease.	D J Selkoe	Nature	1999	10392577	No
2674	2261	1130.5	48.48	24.2	A general framework for weighted gene co-expression network analysis.	Bin Zhang, Steve Horvath	Stat Appl Genet Mol Biol	2005	16646834	Yes
2675	3391	1130.3	79.92	26.6	OrthoMCL: identification of ortholog groups for eukaryotic genomes.	Li Li, Christian J Stoeckert, David S Roos	Genome Res	2003	12952885	Yes
2676	1130	1130.0	43.43	43.4	On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture.	D Collen	Thromb Haemost	1980	6450468	No
2677	3389	1129.7	74.92	25.0	Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM).	Michael J Rust, Mark Bates, Xiaowei Zhuang	Nat Methods	2006	16896339	Yes
2678	2259	1129.5	59.12	29.6	Drug delivery systems: entering the mainstream.	Theresa M Allen, Pieter R Cullis	Science	2004	15031496	Yes
2679	1129	1129.0	31.91	31.9	The biochemistry and medical significance of the flavonoids.	Bent H Havsteen	Pharmacol Ther	2002	12453566	No
2680	1128	1128.0	19.69	19.7	Mitotic kinases as regulators of cell division and its checkpoints.	E A Nigg	Nat Rev Mol Cell Biol	2001	11413462	No
2681	2254	1127.0	155.81	77.9	Facial nerve grading system.	J W House, D E Brackmann	Otolaryngol Head Neck Surg	1985	3921901	Yes
2682	1127	1127.0	20.58	20.6	Stem cells: units of development, units of regeneration, and units in evolution.	I L Weissman	Cell	2000	10647940	No
2683	1127	1127.0	25.32	25.3	The roles of intracellular protein-degradation pathways in neurodegeneration.	David C Rubinsztein	Nature	2006	17051204	No
2684	1127	1127.0	28.82	28.8	Huntington's disease.	Francis O Walker	Lancet	2007	17240289	No
2685	3380	1126.7	68.87	23.0	Predicting coiled coils from protein sequences.	A Lupas, M Van Dyke, J Stock	Science	1991	2031185	Yes
2686	3380	1126.7	90.6	30.2	Wnt/beta-catenin signaling: components, mechanisms, and diseases.	Bryan T MacDonald, Keiko Tamai, Xi He	Dev Cell	2009	19619488	No
2687	1126	1126.0	35.56	35.6	Chronic disease management: what will it take to improve care for chronic illness?	E H Wagner	Eff Clin Pract	1998	10345255	No
2688	1126	1126.0	26.86	26.9	Brain tumors.	L M DeAngelis	N Engl J Med	2001	11150363	No
2689	1126	1126.0	25.68	25.7	Molecular physiology of low-voltage-activated t-type calcium channels.	Edward Perez-Reyes	Physiol Rev	2003	12506128	No
2690	4502	1125.5	112.35	28.1	Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites.	H Nielsen, J Engelbrecht, S Brunak, G von Heijne	Protein Eng	1997	9051728	Yes
2691	1125	1125.0	33.83	33.8	Unstable angina. A classification.	E Braunwald	Circulation	1989	2752565	Yes
2692	1125	1125.0	24.52	24.5	Stem cells in the central nervous system.	R McKay	Science	1997	9082987	No
2693	1124	1124.0	28.88	28.9	Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.	I J Fidler	Cancer Res	1990	1698118	Yes
2694	2247	1123.5	0.0	0.0	Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases.	L M Siegel, K J Monty	Biochim Biophys Acta	1966	5329026	Yes
2695	2247	1123.5	48.42	24.2	Toll-like receptors in the induction of the innate immune response.	A Aderem, R J Ulevitch	Nature	2000	10963608	No
2696	3370	1123.3	101.49	33.8	Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles.	Günter Oberdörster, Eva Oberdörster, Jan Oberdörster	Environ Health Perspect	2005	16002369	No
2697	1123	1123.0	36.38	36.4	Molecular biology of steroid hormone synthesis.	W L Miller	Endocr Rev	1988	3061784	No
2698	1123	1123.0	30.32	30.3	The chromosomal basis of human neoplasia.	J J Yunis	Science	1983	6336310	Yes
2699	1123	1123.0	22.48	22.5	Regulation of transcription by MAP kinase cascades.	R Treisman	Curr Opin Cell Biol	1996	8791420	No
2700	1123	1123.0	34.85	34.9	Low-molecular-weight heparins.	J I Weitz	N Engl J Med	1997	9278467	No
2701	2245	1122.5	0.0	0.0	Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses.	R B Gustilo, J T Anderson	J Bone Joint Surg Am	1976	773941	Yes
2702	2244	1122.0	44.01	22.0	Multiple nuclear factors interact with the immunoglobulin enhancer sequences.	R Sen, D Baltimore	Cell	1986	3091258	Yes
2703	1122	1122.0	23.33	23.3	IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors.	Yong-Jun Liu	Annu Rev Immunol	2005	15771572	No
2704	2244	1122.0	59.58	29.8	Microenvironmental regulation of metastasis.	Johanna A Joyce, Jeffrey W Pollard	Nat Rev Cancer	2009	19279573	No
2705	1122	1122.0	37.86	37.9	Interleukin-1 in the pathogenesis and treatment of inflammatory diseases.	Charles A Dinarello	Blood	2011	21304099	No
2706	3365	1121.7	85.1	28.4	Tissue cells feel and respond to the stiffness of their substrate.	Dennis E Discher, Paul Janmey, Yu-Li Wang	Science	2005	16293750	No
2707	2243	1121.5	61.13	30.6	Analysis of gene control signals by DNA fusion and cloning in Escherichia coli.	M J Casadaban, S N Cohen	J Mol Biol	1980	6997493	Yes
2708	2242	1121.0	65.88	32.9	Increasing incidence of thyroid cancer in the United States, 1973-2002.	Louise Davies, H Gilbert Welch	JAMA	2006	16684987	Yes
2709	2241	1120.5	0.0	0.0	Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice.	J D McGhee, P H von Hippel	J Mol Biol	1974	4416620	Yes
2710	2241	1120.5	0.0	0.0	Active transport of sodium as the source of electric current in the short-circuited isolated frog skin.	H H Ussing, K Zerahn	Acta Physiol Scand	1951	14868510	Yes
2711	2241	1120.5	96.88	48.4	Van der Waals heterostructures.	A K Geim, I V Grigorieva	Nature	2013	23887427	Yes
2712	1120	1120.0	78.35	78.3	The problem of rigor in qualitative research.	M Sandelowski	ANS Adv Nurs Sci	1986	3083765	Yes
2713	1120	1120.0	33.8	33.8	Determinants of tumor blood flow: a review.	R K Jain	Cancer Res	1988	3282647	No
2714	1120	1120.0	40.83	40.8	Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes.	W A Catterall	Annu Rev Pharmacol Toxicol	1980	6247957	No
2715	1120	1120.0	26.79	26.8	Amyloid, the presenilins and Alzheimer's disease.	J Hardy	Trends Neurosci	1997	9106355	No
2716	1120	1120.0	0.0	0.0	On the law of effect.	R J Herrnstein	J Exp Anal Behav	1970	16811440	Yes
2717	2239	1119.5	75.82	37.9	Atomic structure and chemistry of human serum albumin.	X M He, D C Carter	Nature	1992	1630489	Yes
2718	2239	1119.5	66.17	33.1	Excitatory amino acids as a final common pathway for neurologic disorders.	S A Lipton, P A Rosenberg	N Engl J Med	1994	7905600	No
2719	1119	1119.0	33.04	33.0	Cell surface interactions with extracellular materials.	K M Yamada	Annu Rev Biochem	1983	6351729	No
2720	1119	1119.0	31.99	32.0	The induction of pain: an integrative review.	M J Millan	Prog Neurobiol	1999	9987804	No
2721	1119	1119.0	40.77	40.8	Plasma perspective on strong field multiphoton ionization.	Corkum	Phys Rev Lett	1993	10054556	Yes
2722	1119	1119.0	32.23	32.2	How brains beware: neural mechanisms of emotional attention.	Patrik Vuilleumier	Trends Cogn Sci	2005	16289871	Yes
2723	4474	1118.5	108.38	27.1	Base-calling of automated sequencer traces using phred. I. Accuracy assessment.	B Ewing, L Hillier, M C Wendl, P Green	Genome Res	1998	9521921	Yes
2724	1118	1118.0	0.0	0.0	An approach for the treatment of penile carcinoma.	R M Cabanas	Cancer	1977	837331	Yes
2725	2236	1118.0	91.42	45.7	The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure.	R Näätänen, T Picton	Psychophysiology	1987	3615753	Yes
2726	1118	1118.0	44.05	44.0	Translating social ecological theory into guidelines for community health promotion.	D Stokols	Am J Health Promot	1996	10159709	No
2727	1118	1118.0	28.78	28.8	Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science.	Christof M Niemeyer	Angew Chem Int Ed Engl	2001	29712109	No
2728	4471	1117.8	132.01	33.0	Place navigation impaired in rats with hippocampal lesions.	R G Morris, P Garrud, J N Rawlins, J O'Keefe	Nature	1982	7088155	Yes
2729	3353	1117.7	72.32	24.1	Toll-like receptors: critical proteins linking innate and acquired immunity.	S Akira, K Takeda, T Kaisho	Nat Immunol	2001	11477402	No
2730	2235	1117.5	50.84	25.4	The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications.	P M Sharp, W H Li	Nucleic Acids Res	1987	3547335	Yes
2731	1117	1117.0	0.0	0.0	Optimal foraging, the marginal value theorem.	E L Charnov	Theor Popul Biol	1976	1273796	Yes
2732	1117	1117.0	30.5	30.5	Pain and emotion interactions in subregions of the cingulate gyrus.	Brent A Vogt	Nat Rev Neurosci	2005	15995724	No
2733	1117	1117.0	0.0	0.0	The generalisation of student's problems when several different population variances are involved.	B L Welch	Biometrika	1947	20287819	Yes
2734	17866	1116.6	681.46	42.6	Fiji: an open-source platform for biological-image analysis.	Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert Cardona	Nat Methods	2012	22743772	Yes
2735	4466	1116.5	105.28	26.3	SCOP: a structural classification of proteins database for the investigation of sequences and structures.	A G Murzin, S E Brenner, T Hubbard, C Chothia	J Mol Biol	1995	7723011	Yes
2736	1116	1116.0	23.88	23.9	Mutator phenotype may be required for multistage carcinogenesis.	L A Loeb	Cancer Res	1991	2039987	No
2737	1116	1116.0	36.91	36.9	Endometriosis.	Serdar E Bulun	N Engl J Med	2009	19144942	No
2738	4460	1115.0	101.56	25.4	Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.	J E Walker, M Saraste, M J Runswick, N J Gay	EMBO J	1982	6329717	Yes
2739	2230	1115.0	77.82	38.9	Quality control and preprocessing of metagenomic datasets.	Robert Schmieder, Robert Edwards	Bioinformatics	2011	21278185	Yes
2740	2229	1114.5	63.38	31.7	Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.	R G Phillips, J E LeDoux	Behav Neurosci	1992	1590953	Yes
2741	1114	1114.0	30.9	30.9	Diseases of the mitochondrial DNA.	D C Wallace	Annu Rev Biochem	1992	1497308	No
2742	1114	1114.0	39.42	39.4	Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds.	A J Alpert	J Chromatogr	1990	2324207	Yes
2743	1114	1114.0	26.63	26.6	Allelic discrimination using fluorogenic probes and the 5' nuclease assay.	K J Livak	Genet Anal	1999	10084106	Yes
2744	1114	1114.0	31.15	31.1	Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence.	Earl S Ford	Diabetes Care	2005	15983333	No
2745	3342	1114.0	99.41	33.1	Nitric oxide and peroxynitrite in health and disease.	Pál Pacher, Joseph S Beckman, Lucas Liaudet	Physiol Rev	2007	17237348	No
2746	3341	1113.7	87.26	29.1	Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya.	C R Woese, O Kandler, M L Wheelis	Proc Natl Acad Sci U S A	1990	2112744	Yes
2747	3341	1113.7	124.62	41.5	Rehospitalizations among patients in the Medicare fee-for-service program.	Stephen F Jencks, Mark V Williams, Eric A Coleman	N Engl J Med	2009	19339721	Yes
2748	1113	1113.0	27.07	27.1	Metastatic bone disease: clinical features, pathophysiology and treatment strategies.	R E Coleman	Cancer Treat Rev	2001	11417967	No
2749	1112	1112.0	0.0	0.0	Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb.	J Altman	J Comp Neurol	1969	5361244	Yes
2750	1112	1112.0	33.67	33.7	Reducing children's television viewing to prevent obesity: a randomized controlled trial.	T N Robinson	JAMA	1999	10546696	Yes
2751	1112	1112.0	25.68	25.7	Gene finding in novel genomes.	Ian Korf	BMC Bioinformatics	2004	15144565	Yes
2752	1112	1112.0	30.75	30.8	Polymer conjugates as anticancer nanomedicines.	Ruth Duncan	Nat Rev Cancer	2006	16900224	No
2753	2223	1111.5	66.66	33.3	Nitric oxide synthases in mammals.	R G Knowles, S Moncada	Biochem J	1994	7510950	No
2754	2223	1111.5	0.0	0.0	Construct validity in psychological tests.	L J Cronbach, P E Meehl	Psychol Bull	1955	13245896	Yes
2755	1111	1111.0	33.99	34.0	The structure of common mental disorders.	R F Krueger	Arch Gen Psychiatry	1999	10530634	Yes
2756	1110	1110.0	0.0	0.0	Cytoprotection by prostaglandins.	A Robert	Gastroenterology	1979	38173	Yes
2757	1110	1110.0	28.94	28.9	Linkage strategies for genetically complex traits. I. Multilocus models.	N Risch	Am J Hum Genet	1990	2301392	Yes
2758	1110	1110.0	0.0	0.0	Studies on histones. 7. Preparative methods for histone fractions from calf thymus.	E W Johns	Biochem J	1964	5840387	Yes
2759	4438	1109.5	123.67	30.9	Microbial ecology: human gut microbes associated with obesity.	Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I Gordon	Nature	2006	17183309	Yes
2760	2219	1109.5	65.77	32.9	Alternative activation of macrophages: mechanism and functions.	Siamon Gordon, Fernando O Martinez	Immunity	2010	20510870	No
2761	3328	1109.3	68.92	23.0	The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.	Fabio Martinon, Kimberly Burns, Jürg Tschopp	Mol Cell	2002	12191486	Yes
2762	1109	1109.0	21.18	21.2	Luciferase reporter gene vectors for analysis of promoters and enhancers.	S K Nordeen	Biotechniques	1988	2908509	Yes
2763	1109	1109.0	0.0	0.0	6-Hydroxy-dopamine induced degeneration of central monoamine neurons.	U Ungerstedt	Eur J Pharmacol	1968	5718510	Yes
2764	2218	1109.0	0.0	0.0	Micromethod for the direct determination of serum triglycerides.	E Van Handel, D B Zilversmit	J Lab Clin Med	1957	13439279	Yes
2765	3327	1109.0	78.24	26.1	Hepatocellular carcinoma.	Josep M Llovet, Andrew Burroughs, Jordi Bruix	Lancet	2003	14667750	No
2766	1109	1109.0	25.27	25.3	Solving structures of protein complexes by molecular replacement with Phaser.	Airlie J McCoy	Acta Crystallogr D Biol Crystallogr	2007	17164524	Yes
2767	2217	1108.5	0.0	0.0	A revision of the Schoenheimer-Sperry method for cholesterol determination.	W M Sperry, M Webb	J Biol Chem	1950	14794694	Yes
2768	2217	1108.5	61.82	30.9	Neural systems of reinforcement for drug addiction: from actions to habits to compulsion.	Barry J Everitt, Trevor W Robbins	Nat Neurosci	2005	16251991	No
2769	2216	1108.0	61.14	30.6	Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients.	S Schulman, C Kearon	J Thromb Haemost	2005	15842354	Yes
2770	1107	1107.0	0.0	0.0	Metabolic stability and epigenesis in randomly constructed genetic nets.	S A Kauffman	J Theor Biol	1969	5803332	Yes
2771	1107	1107.0	23.43	23.4	Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy.	Harold F Dvorak	J Clin Oncol	2002	12409337	No
2772	3319	1106.3	106.88	35.6	Dose translation from animal to human studies revisited.	Shannon Reagan-Shaw, Minakshi Nihal, Nihal Ahmad	FASEB J	2008	17942826	Yes
2773	1106	1106.0	0.0	0.0	Structure of chromatin.	R D Kornberg	Annu Rev Biochem	1977	332067	No
2774	1106	1106.0	34.79	34.8	Energy contributions of volatile fatty acids from the gastrointestinal tract in various species.	E N Bergman	Physiol Rev	1990	2181501	No
2775	1106	1106.0	25.38	25.4	Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes.	M Kozak	Nucleic Acids Res	1981	7301588	Yes
2776	2212	1106.0	44.32	22.2	NF-kappaB at the crossroads of life and death.	Michael Karin, Anning Lin	Nat Immunol	2002	11875461	No
2777	1106	1106.0	36.17	36.2	Risk and maintenance factors for eating pathology: a meta-analytic review.	Eric Stice	Psychol Bull	2002	12206196	No
2778	1106	1106.0	0.0	0.0	The Nature Of Herpes Zoster: A Long-Term Study And A New Hypothesis.	R E Hope-Simpson	Proc R Soc Med	1965	14267505	Yes
2779	1105	1105.0	35.52	35.5	Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate.	J E Oesterling	J Urol	1991	1707989	No
2780	2210	1105.0	49.21	24.6	Prediction of protein secondary structure at better than 70% accuracy.	B Rost, C Sander	J Mol Biol	1993	8345525	Yes
2781	2209	1104.5	0.0	0.0	Microdroplet Assay Of Human Serum Cytotoxins.	P I Terasaki, J D Mcclelland	Nature	1964	14248725	Yes
2782	2208	1104.0	48.13	24.1	Atherosclerosis. the road ahead.	C K Glass, J L Witztum	Cell	2001	11239408	No
2783	2208	1104.0	50.92	25.5	Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms.	Eugenia E Calle, Rudolf Kaaks	Nat Rev Cancer	2004	15286738	No
2784	2208	1104.0	62.35	31.2	Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments.	Gerard Talavera, Jose Castresana	Syst Biol	2007	17654362	Yes
2785	1104	1104.0	31.23	31.2	Plant productivity and environment.	J S Boyer	Science	1982	17808529	Yes
2786	2207	1103.5	43.8	21.9	Homeobox genes and axial patterning.	W McGinnis, R Krumlauf	Cell	1992	1346368	No
2787	2206	1103.0	41.19	20.6	Stats: transcriptional control and biological impact.	David E Levy, J E Darnell	Nat Rev Mol Cell Biol	2002	12209125	No
2788	1103	1103.0	0.0	0.0	Preliminary Trial Of Carisoprodol In Multiple Sclerosis.	B Ashworth	Practitioner	1964	14143329	Yes
2789	1103	1103.0	26.75	26.8	Production of recombinant protein therapeutics in cultivated mammalian cells.	Florian M Wurm	Nat Biotechnol	2004	15529164	No
2790	1103	1103.0	35.49	35.5	Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.	Felix Kratz	J Control Release	2008	18582981	No
2791	1103	1103.0	31.13	31.1	Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics.	G L Semenza	Oncogene	2010	19946328	No
2792	1102	1102.0	40.01	40.0	The LMS method for constructing normalized growth standards.	T J Cole	Eur J Clin Nutr	1990	2354692	Yes
2793	1102	1102.0	37.67	37.7	Chemoprevention of cancer.	L W Wattenberg	Cancer Res	1985	3880665	No
2794	1102	1102.0	23.57	23.6	ALSCRIPT: a tool to format multiple sequence alignments.	G J Barton	Protein Eng	1993	8433969	Yes
2795	1102	1102.0	0.0	0.0	Voluntary strength and fatigue.	P A Merton	J Physiol	1954	13152698	Yes
2796	2204	1102.0	52.13	26.1	Toll-like receptors in innate immunity.	Kiyoshi Takeda, Shizuo Akira	Int Immunol	2005	15585605	No
2797	1102	1102.0	25.49	25.5	Neuroligins and neurexins link synaptic function to cognitive disease.	Thomas C Südhof	Nature	2008	18923512	No
2798	1101	1101.0	0.0	0.0	Knee joint changes after meniscectomy.	T J Fairbank	J Bone Joint Surg Br	1948	18894618	Yes
2799	1100	1100.0	0.0	0.0	Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units.	C M Venkatachalam	Biopolymers	1968	5685102	Yes
2800	1100	1100.0	43.36	43.4	Molecular aspects of ligand binding to serum albumin.	U Kragh-Hansen	Pharmacol Rev	1981	7027277	No
2801	1100	1100.0	0.0	0.0	The powerful placebo.	H K Beecher	J Am Med Assoc	1955	13271123	Yes
2802	1100	1100.0	0.0	0.0	Inherited Antithrombin Deficiency Causing Thrombophilia.	O Egeberg	Thromb Diath Haemorrh	1965	14347873	Yes
2803	1100	1100.0	30.43	30.4	Hydrogen sulphide and its therapeutic potential.	Csaba Szabó	Nat Rev Drug Discov	2007	17948022	No
2804	2199	1099.5	140.75	70.4	A joint coordinate system for the clinical description of three-dimensional motions: application to the knee.	E S Grood, W J Suntay	J Biomech Eng	1983	6865355	Yes
2805	3298	1099.3	0.0	0.0	Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.	M Hamberg, J Svensson, B Samuelsson	Proc Natl Acad Sci U S A	1975	1059088	Yes
2806	6595	1099.2	178.65	29.8	Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research.	Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat Robles	Bioinformatics	2005	16081474	Yes
2807	1099	1099.0	25.03	25.0	Microglia as a source and target of cytokines.	Uwe-Karsten Hanisch	Glia	2002	12379902	No
2808	1099	1099.0	21.99	22.0	Microarray data normalization and transformation.	John Quackenbush	Nat Genet	2002	12454644	No
2809	1099	1099.0	36.83	36.8	Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations.	Ronald A Hites	Environ Sci Technol	2004	14998004	Yes
2810	2197	1098.5	45.6	22.8	Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133.	G A Gonzalez, M R Montminy	Cell	1989	2573431	Yes
2811	2197	1098.5	0.0	0.0	Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms.	R J Britten, D E Kohne	Science	1968	4874239	Yes
2812	2197	1098.5	0.0	0.0	Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody.	A H Coons, M H Kaplan	J Exp Med	1950	15395569	Yes
2813	1098	1098.0	31.08	31.1	Normalization of cell responses in cat striate cortex.	D J Heeger	Vis Neurosci	1992	1504027	Yes
2814	1098	1098.0	0.0	0.0	The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion.	S Roseman	Chem Phys Lipids	1970	5476326	Yes
2815	12074	1097.6	438.93	39.9	A new equation to estimate glomerular filtration rate.	Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef Coresh	Ann Intern Med	2009	19414839	Yes
2816	1097	1097.0	23.06	23.1	Differentiation and proliferation of hematopoietic stem cells.	M Ogawa	Blood	1993	8499622	No
2817	1097	1097.0	0.0	0.0	A cytoarchitectonic atlas of the spinal cord in the cat.	B Rexed	J Comp Neurol	1954	13163236	Yes
2818	1097	1097.0	29.86	29.9	Wound healing and its impairment in the diabetic foot.	Vincent Falanga	Lancet	2005	16291068	No
2819	2193	1096.5	0.0	0.0	Construction of phylogenetic trees.	W M Fitch, E Margoliash	Science	1967	5334057	No
2820	2192	1096.0	72.41	36.2	Excitatory amino acid transmitters.	J C Watkins, R H Evans	Annu Rev Pharmacol Toxicol	1981	6112965	No
2821	1096	1096.0	37.24	37.2	High density lipoprotein metabolism.	S Eisenberg	J Lipid Res	1984	6392459	No
2822	1096	1096.0	26.48	26.5	The prefrontal cortex and cognitive control.	E K Miller	Nat Rev Neurosci	2000	11252769	No
2823	1096	1096.0	30.82	30.8	Neural simulation of action: a unifying mechanism for motor cognition.	M Jeannerod	Neuroimage	2001	11373140	No
2824	1096	1096.0	34.77	34.8	Cytokinesis-block micronucleus cytome assay.	Michael Fenech	Nat Protoc	2007	17546000	Yes
2825	1095	1095.0	103.95	104.0	The analysis of errors in orthodontic measurements.	W J Houston	Am J Orthod	1983	6573846	Yes
2826	1095	1095.0	24.73	24.7	The molecular biology of leukocyte chemoattractant receptors.	P M Murphy	Annu Rev Immunol	1994	8011292	No
2827	1095	1095.0	30.88	30.9	Leishmaniasis.	B L Herwaldt	Lancet	1999	10513726	No
2828	1095	1095.0	27.52	27.5	Metabolism and functions of glutathione in brain.	R Dringen	Prog Neurobiol	2000	10880854	No
2829	4380	1095.0	121.24	30.3	Prevalence and trends in obesity among US adults, 1999-2000.	Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L Johnson	JAMA	2002	12365955	Yes
2830	1095	1095.0	30.38	30.4	Q-ball imaging.	David S Tuch	Magn Reson Med	2004	15562495	Yes
2831	2189	1094.5	50.26	25.1	Adaptive protein evolution at the Adh locus in Drosophila.	J H McDonald, M Kreitman	Nature	1991	1904993	Yes
2832	6567	1094.5	229.45	38.2	The occurrence of sleep-disordered breathing among middle-aged adults.	T Young, M Palta, J Dempsey, J Skatrud, S Weber, S Badr	N Engl J Med	1993	8464434	Yes
2833	1094	1094.0	0.0	0.0	Sex-hormone-binding globulin.	D C Anderson	Clin Endocrinol (Oxf)	1974	4134992	No
2834	1094	1094.0	37.4	37.4	Selective attention and the organization of visual information.	J Duncan	J Exp Psychol Gen	1984	6240521	Yes
2835	1094	1094.0	24.68	24.7	Physiological concentrations of purines and pyrimidines.	T W Traut	Mol Cell Biochem	1994	7877593	No
2836	1094	1094.0	25.58	25.6	Neurobiology of Pavlovian fear conditioning.	S Maren	Annu Rev Neurosci	2001	11520922	No
2837	2188	1094.0	64.34	32.2	The cognitive control of emotion.	Kevin N Ochsner, James J Gross	Trends Cogn Sci	2005	15866151	No
2838	2188	1094.0	70.35	35.2	Natural products as sources of new drugs over the last 25 years.	David J Newman, Gordon M Cragg	J Nat Prod	2007	17309302	No
2839	7656	1093.7	160.38	22.9	Exploration, normalization, and summaries of high density oligonucleotide array probe level data.	Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P Speed	Biostatistics	2003	12925520	Yes
2840	2187	1093.5	67.27	33.6	A cognitive model of posttraumatic stress disorder.	A Ehlers, D M Clark	Behav Res Ther	2000	10761279	No
2841	1093	1093.0	22.34	22.3	Primary response genes induced by growth factors and tumor promoters.	H R Herschman	Annu Rev Biochem	1991	1883198	No
2842	2186	1093.0	63.47	31.7	Meeting of minds: the medial frontal cortex and social cognition.	David M Amodio, Chris D Frith	Nat Rev Neurosci	2006	16552413	No
2843	1093	1093.0	0.0	0.0	Immunogenetic Consequences Of Vascular Anastomoses Between Bovine Twins.	R D Owen	Science	1945	17755278	Yes
2844	1093	1093.0	25.7	25.7	Recognition and processing of ubiquitin-protein conjugates by the proteasome.	Daniel Finley	Annu Rev Biochem	2009	19489727	No
2845	2186	1093.0	91.08	45.5	Neutrophil recruitment and function in health and inflammation.	Elzbieta Kolaczkowska, Paul Kubes	Nat Rev Immunol	2013	23435331	No
2846	1092	1092.0	29.07	29.1	Neural systems for recognizing emotion.	Ralph Adolphs	Curr Opin Neurobiol	2002	12015233	No
2847	2182	1091.0	96.02	48.0	Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity.	P R Hunter, M A Gaston	J Clin Microbiol	1988	3069867	Yes
2848	1091	1091.0	41.99	42.0	The role of endothelium in the responses of vascular smooth muscle to drugs.	R F Furchgott	Annu Rev Pharmacol Toxicol	1984	6203480	No
2849	1091	1091.0	0.0	0.0	Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow.	R M Berne	Am J Physiol	1963	13971060	Yes
2850	1091	1091.0	34.12	34.1	High prevalence of vitamin D inadequacy and implications for health.	Michael F Holick	Mayo Clin Proc	2006	16529140	No
2851	1090	1090.0	39.4	39.4	Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases.	J N Wasserheit	Sex Transm Dis	1992	1595015	No
2852	1090	1090.0	30.82	30.8	Internal models for motor control and trajectory planning.	M Kawato	Curr Opin Neurobiol	1999	10607637	No
2853	1090	1090.0	23.35	23.4	Basement membranes: structure, assembly and role in tumour angiogenesis.	Raghu Kalluri	Nat Rev Cancer	2003	12778132	No
2854	2180	1090.0	72.2	36.1	An estimate of the worldwide prevalence and disability associated with osteoporotic fractures.	O Johnell, J A Kanis	Osteoporos Int	2006	16983459	Yes
2855	1089	1089.0	41.41	41.4	Omega-3 fatty acids in health and disease and in growth and development.	A P Simopoulos	Am J Clin Nutr	1991	1908631	No
2856	1089	1089.0	23.09	23.1	A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.	J Milbrandt	Science	1987	3672127	Yes
2857	2178	1089.0	61.16	30.6	Epidemiology and outcomes of osteoporotic fractures.	Steven R Cummings, L Joseph Melton	Lancet	2002	12049882	No
2858	1089	1089.0	0.0	0.0	The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease.	J Vague	Am J Clin Nutr	1956	13282851	Yes
2859	1089	1089.0	0.0	0.0	The purine and pyrimidine composition of deoxypentose nucleic acids.	G R Wyatt	Biochem J	1951	14838906	Yes
2860	1088	1088.0	22.98	23.0	T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex.	R H Schwartz	Annu Rev Immunol	1985	2415139	No
2861	1088	1088.0	56.94	56.9	Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale.	Anna Maria Carlsson	Pain	1983	6602967	Yes
2862	1088	1088.0	29.53	29.5	The neurobiology of stress: from serendipity to clinical relevance.	B S McEwen	Brain Res	2000	11119695	No
2863	1088	1088.0	30.52	30.5	Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS.	Paul Willner	Neuropsychobiology	2005	16037678	No
2864	2176	1088.0	78.75	39.4	Oncology meets immunology: the cancer-immunity cycle.	Daniel S Chen, Ira Mellman	Immunity	2013	23890059	No
2865	4350	1087.5	267.53	66.9	IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies.	Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang Minh	Mol Biol Evol	2015	25371430	Yes
2866	1087	1087.0	44.0	44.0	Social phobia.	M R Liebowitz	Mod Probl Pharmacopsychiatry	1987	2885745	Yes
2867	1087	1087.0	21.29	21.3	Regulation of phosphoinositide-specific phospholipase C.	S G Rhee	Annu Rev Biochem	2001	11395409	No
2868	1087	1087.0	36.41	36.4	Delirium in older persons.	Sharon K Inouye	N Engl J Med	2006	16540616	No
2869	1087	1087.0	0.0	0.0	Intra-sexual selection in Drosophila.	A J Bateman	Heredity (Edinb)	1948	18103134	Yes
2870	2173	1086.5	52.73	26.4	Emerging roles of caspase-3 in apoptosis.	A G Porter, R U Jänicke	Cell Death Differ	1999	10200555	No
2871	1086	1086.0	46.04	46.0	A cochlear frequency-position function for several species--29 years later.	D D Greenwood	J Acoust Soc Am	1990	2373794	Yes
2872	1086	1086.0	21.81	21.8	Cytokine receptor signalling.	J N Ihle	Nature	1995	7566171	No
2873	2172	1086.0	44.09	22.0	Proliferation, cell cycle and apoptosis in cancer.	G I Evan, K H Vousden	Nature	2001	11357141	No
2874	3256	1085.3	71.9	24.0	A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.	M Serrano, G J Hannon, D Beach	Nature	1993	8259215	Yes
2875	5426	1085.2	189.72	37.9	Posttraumatic stress disorder in the National Comorbidity Survey.	R C Kessler, A Sonnega, E Bromet, M Hughes, C B Nelson	Arch Gen Psychiatry	1995	7492257	Yes
2876	1085	1085.0	0.0	0.0	Corticosteroids and lymphoid cells.	H N Claman	N Engl J Med	1972	5043524	Yes
2877	2168	1084.0	76.94	38.5	The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis.	G P Chrousos, P W Gold	JAMA	1992	1538563	No
2878	2167	1083.5	107.09	53.5	ROS function in redox signaling and oxidative stress.	Michael Schieber, Navdeep S Chandel	Curr Biol	2014	24845678	No
2879	1083	1083.0	45.01	45.0	Bone "mass" and the "mechanostat": a proposal.	H M Frost	Anat Rec	1987	3688455	Yes
2880	2166	1083.0	40.71	20.4	Hedgehog signaling in animal development: paradigms and principles.	P W Ingham, A P McMahon	Genes Dev	2001	11731473	No
2881	2166	1083.0	47.79	23.9	NF-kappaB: linking inflammation and immunity to cancer development and progression.	Michael Karin, Florian R Greten	Nat Rev Immunol	2005	16175180	No
2882	7579	1082.7	284.61	40.7	GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.	Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J Schünemann	BMJ	2008	18436948	Yes
2883	1082	1082.0	23.01	23.0	Apoptosis in neurodegenerative disorders.	M P Mattson	Nat Rev Mol Cell Biol	2000	11253364	No
2884	1082	1082.0	30.8	30.8	Physiology and pathophysiology of purinergic neurotransmission.	Geoffrey Burnstock	Physiol Rev	2007	17429044	No
2885	4325	1081.2	103.74	25.9	Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.	G L Wang, B H Jiang, E A Rue, G L Semenza	Proc Natl Acad Sci U S A	1995	7539918	Yes
2886	1081	1081.0	40.78	40.8	The P300 wave of the human event-related potential.	T W Picton	J Clin Neurophysiol	1992	1464675	No
2887	2162	1081.0	62.56	31.3	Ageing and Parkinson's disease: substantia nigra regional selectivity.	J M Fearnley, A J Lees	Brain	1991	1933245	Yes
2888	1081	1081.0	0.0	0.0	A kinetic photometric method for serum gamma-glutamyl transpeptidase.	G Szasz	Clin Chem	1969	5773262	Yes
2889	1081	1081.0	26.83	26.8	The sphingomyelin cycle and the second messenger function of ceramide.	Y A Hannun	J Biol Chem	1994	8106344	No
2890	1081	1081.0	0.0	0.0	Aniline hydrogen phthalate as a spraying reagent for chromatography of sugars.	S M Partridge	Nature	1949	18140444	Yes
2891	1081	1081.0	28.71	28.7	Non-Smad pathways in TGF-beta signaling.	Ying E Zhang	Cell Res	2009	19114990	No
2892	1081	1081.0	38.73	38.7	Breakthrough of the year 2013. Cancer immunotherapy.	Jennifer Couzin-Frankel	Science	2013	24357284	No
2893	7563	1080.4	254.98	36.4	AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility.	Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J Olson	J Comput Chem	2009	19399780	Yes
2894	1080	1080.0	27.77	27.8	Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol.	M J Berridge	Biochem J	1983	6309155	Yes
2895	1080	1080.0	30.69	30.7	Pharmacology of cannabinoid CB1 and CB2 receptors.	R G Pertwee	Pharmacol Ther	1997	9336020	No
2896	1080	1080.0	0.0	0.0	The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs.	M Vogt	J Physiol	1954	13152692	Yes
2897	1080	1080.0	28.43	28.4	Overview of general physiologic features and functions of vitamin D.	Hector F DeLuca	Am J Clin Nutr	2004	15585789	No
2898	1080	1080.0	31.78	31.8	Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective.	Antoine Bechara	Nat Neurosci	2005	16251988	No
2899	2160	1080.0	62.03	31.0	A neurotrophic model for stress-related mood disorders.	Ronald S Duman, Lisa M Monteggia	Biol Psychiatry	2006	16631126	No
2900	1079	1079.0	32.24	32.2	Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing.	M J Gasson	J Bacteriol	1983	6403500	Yes
2901	1079	1079.0	0.0	0.0	The relation of the trail making test to organic brain damage.	R M Reitan	J Consult Psychol	1955	13263471	Yes
2902	1079	1079.0	0.0	0.0	A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces.	M G Buonocore	J Dent Res	1955	13271655	Yes
2903	2158	1079.0	47.41	23.7	The mammalian unfolded protein response.	Martin Schröder, Randal J Kaufman	Annu Rev Biochem	2005	15952902	No
2904	2157	1078.5	45.88	22.9	p53: puzzle and paradigm.	L J Ko, C Prives	Genes Dev	1996	8654922	No
2905	1078	1078.0	0.0	0.0	Cleavage of the haem-protein link by acid methylethylketone.	F W Teale	Biochim Biophys Acta	1959	13837237	Yes
2906	2154	1077.0	81.85	40.9	Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal.	H Esterbauer, K H Cheeseman	Methods Enzymol	1990	2233308	Yes
2907	2154	1077.0	43.54	21.8	RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression.	M B Shapiro, P Senapathy	Nucleic Acids Res	1987	3658675	Yes
2908	1077	1077.0	34.24	34.2	The oxidation hypothesis of atherosclerosis.	J L Witztum	Lancet	1994	7916078	No
2909	1077	1077.0	0.0	0.0	Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye.	P B Medawar	Br J Exp Pathol	1948	18865105	Yes
2910	1076	1076.0	42.0	42.0	A new international staging system for lung cancer.	C F Mountain	Chest	1986	3514171	No
2911	1076	1076.0	46.26	46.3	A spreading-activation theory of retrieval in sentence production.	G S Dell	Psychol Rev	1986	3749399	Yes
2912	1076	1076.0	0.0	0.0	A teacher rating scale for use in drug studies with children.	C K Conners	Am J Psychiatry	1969	4900822	Yes
2913	1076	1076.0	0.0	0.0	Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities.	F Fonnum	Biochem J	1969	4982085	Yes
2914	1076	1076.0	33.79	33.8	Context, time, and memory retrieval in the interference paradigms of Pavlovian learning.	M E Bouton	Psychol Bull	1993	8346330	No
2915	1076	1076.0	23.68	23.7	An overview of epithelio-mesenchymal transformation.	E D Hay	Acta Anat (Basel)	1995	8714286	No
2916	1076	1076.0	27.54	27.5	Optical microcavities.	Kerry J Vahala	Nature	2003	12917698	Yes
2917	2151	1075.5	0.0	0.0	Peroxidase-labeled antibody. A new method of conjugation.	P K Nakane, A Kawaoi	J Histochem Cytochem	1974	4443551	Yes
2918	4302	1075.5	110.32	27.6	Autophagy fights disease through cellular self-digestion.	Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky	Nature	2008	18305538	No
2919	2150	1075.0	41.55	20.8	Dynamic instability of microtubule growth.	T Mitchison, M Kirschner	Nature	1984	6504138	Yes
2920	1075	1075.0	30.25	30.2	Venous thrombosis: a multicausal disease.	F R Rosendaal	Lancet	1999	10209995	No
2921	2150	1075.0	55.05	27.5	C-reactive protein: a critical update.	Mark B Pepys, Gideon M Hirschfield	J Clin Invest	2003	12813013	No
2922	1074	1074.0	30.78	30.8	Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens.	T Feizi	Nature	1985	2579340	Yes
2923	1074	1074.0	25.86	25.9	Molecular drive: a cohesive mode of species evolution.	G Dover	Nature	1982	7110332	Yes
2924	1074	1074.0	31.56	31.6	The effects of stressful life events on depression.	R C Kessler	Annu Rev Psychol	1997	9046559	No
2925	1074	1074.0	22.06	22.1	A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development.	Xuemei Chen	Science	2004	12893888	Yes
2926	1074	1074.0	0.0	0.0	A New Serum Type System In Man--The Lp System.	K Berg	Acta Pathol Microbiol Scand	1963	14064818	Yes
2927	1074	1074.0	25.64	25.6	Human natural killer cells.	Michael A Caligiuri	Blood	2008	18650461	No
2928	1073	1073.0	0.0	0.0	Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method.	K Satoh	Clin Chim Acta	1978	719890	Yes
2929	1073	1073.0	0.0	0.0	Asymptomatic infections of the urinary tract.	E H Kass	Trans Assoc Am Physicians	1956	13380946	Yes
2930	1073	1073.0	22.48	22.5	Inferences, questions and possibilities in Toll-like receptor signalling.	Bruce Beutler	Nature	2004	15241424	No
2931	1073	1073.0	27.37	27.4	Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis.	R Balfour Sartor	Nat Clin Pract Gastroenterol Hepatol	2006	16819502	No
2932	2145	1072.5	44.66	22.3	An automated method for finding molecular complexes in large protein interaction networks.	Gary D Bader, Christopher W V Hogue	BMC Bioinformatics	2003	12525261	Yes
2933	1072	1072.0	27.59	27.6	Selectins: interpreters of cell-specific carbohydrate information during inflammation.	L A Lasky	Science	1992	1439808	No
2934	6432	1072.0	141.77	23.6	Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.	D A Melton, P A Krieg, M R Rebagliati, T Maniatis, K Zinn, M R Green	Nucleic Acids Res	1984	6091052	Yes
2935	1072	1072.0	20.27	20.3	The development of neural stem cells.	S Temple	Nature	2001	11689956	No
2936	1072	1072.0	33.47	33.5	Water as an active constituent in cell biology.	Philip Ball	Chem Rev	2008	18095715	No
2937	2143	1071.5	57.95	29.0	Oxidative stress, caloric restriction, and aging.	R S Sohal, R Weindruch	Science	1996	8658196	No
2938	3214	1071.3	104.02	34.7	MR diffusion tensor spectroscopy and imaging.	P J Basser, J Mattiello, D LeBihan	Biophys J	1994	8130344	Yes
2939	3214	1071.3	107.58	35.9	Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS.	B K Matuszewski, M L Constanzer, C M Chavez-Eng	Anal Chem	2003	12964746	Yes
2940	1071	1071.0	37.76	37.8	Multiple organ failure. Pathophysiology and potential future therapy.	E A Deitch	Ann Surg	1992	1503516	No
2941	1071	1071.0	30.52	30.5	Mitochondrial fusion and fission in cell life and death.	Benedikt Westermann	Nat Rev Mol Cell Biol	2010	21102612	No
2942	2141	1070.5	52.39	26.2	Cellular processing of platinum anticancer drugs.	Dong Wang, Stephen J Lippard	Nat Rev Drug Discov	2005	15789122	No
2943	2141	1070.5	95.99	48.0	The future of immune checkpoint therapy.	Padmanee Sharma, James P Allison	Science	2015	25838373	No
2944	1070	1070.0	25.11	25.1	Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.	S H Kaufmann	Cancer Res	1989	2790800	Yes
2945	1070	1070.0	32.56	32.6	A human model of gastric carcinogenesis.	P Correa	Cancer Res	1988	3288329	No
2946	2140	1070.0	66.13	33.1	2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity.	A Poland, J C Knutson	Annu Rev Pharmacol Toxicol	1982	6282188	No
2947	1070	1070.0	33.92	33.9	Strategies of antioxidant defense.	H Sies	Eur J Biochem	1993	7688300	No
2948	2139	1069.5	0.0	0.0	Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme.	A Warshel, M Levitt	J Mol Biol	1976	985660	Yes
2949	2139	1069.5	47.5	23.8	Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age.	T Hunter, J Pines	Cell	1994	7954824	No
2950	1069	1069.0	21.6	21.6	Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.	A S Baldwin	J Clin Invest	2001	11160144	No
2951	2137	1068.5	68.38	34.2	Stochastic relaxation, gibbs distributions, and the bayesian restoration of images.	S Geman, D Geman	IEEE Trans Pattern Anal Mach Intell	1984	22499653	Yes
2952	2136	1068.0	0.0	0.0	Binding of soluble form of fibroblast surface protein, fibronectin, to collagen.	E Engvall, E Ruoslahti	Int J Cancer	1977	903179	Yes
2953	1068	1068.0	32.8	32.8	What is synergy?	M C Berenbaum	Pharmacol Rev	1989	2692037	No
2954	1068	1068.0	32.2	32.2	Cholesterol and the cell membrane.	P L Yeagle	Biochim Biophys Acta	1985	3904832	No
2955	2136	1068.0	48.23	24.1	Cell cycle control and cancer.	L H Hartwell, M B Kastan	Science	1994	7997877	No
2956	1068	1068.0	23.63	23.6	PHD: predicting one-dimensional protein structure by profile-based neural networks.	B Rost	Methods Enzymol	1996	8743704	Yes
2957	2136	1068.0	0.0	0.0	Demonstration Of Tumor-Specific Antigens In Human Colonic Carcinomata By Immunological Tolerance And Absorption Techniques.	P Gold, S O Freedman	J Exp Med	1965	14270243	Yes
2958	4270	1067.5	154.4	38.6	Guidelines for the process of cross-cultural adaptation of self-report measures.	D E Beaton, C Bombardier, F Guillemin, M B Ferraz	Spine (Phila Pa 1976)	2000	11124735	No
2959	2135	1067.5	96.49	48.2	The M1 and M2 paradigm of macrophage activation: time for reassessment.	Fernando O Martinez, Siamon Gordon	F1000Prime Rep	2014	24669294	No
2960	2135	1067.5	94.34	47.2	Neoantigens in cancer immunotherapy.	Ton N Schumacher, Robert D Schreiber	Science	2015	25838375	No
2961	2134	1067.0	0.0	0.0	T antigen is bound to a host protein in SV40-transformed cells.	D P Lane, L V Crawford	Nature	1979	218111	Yes
2962	2134	1067.0	68.61	34.3	Glutamate and the pathophysiology of hypoxic--ischemic brain damage.	S M Rothman, J W Olney	Ann Neurol	1986	2421636	No
2963	1067	1067.0	29.78	29.8	Aging, energy, and oxidative stress in neurodegenerative diseases.	M F Beal	Ann Neurol	1995	7668820	No
2964	1067	1067.0	36.48	36.5	Mitochondria and cancer.	Douglas C Wallace	Nat Rev Cancer	2012	23001348	No
2965	4267	1066.8	129.62	32.4	Toxic potential of materials at the nanolevel.	Andre Nel, Tian Xia, Lutz Mädler, Ning Li	Science	2006	16456071	No
2966	2132	1066.0	74.3	37.1	Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation.	A E Czeizel, I Dudás	N Engl J Med	1992	1307234	Yes
2967	1066	1066.0	28.52	28.5	Disorders of iron metabolism.	N C Andrews	N Engl J Med	1999	10607817	No
2968	1066	1066.0	25.21	25.2	Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial.	H J Dargie	Lancet	2001	11356434	Yes
2969	2132	1066.0	0.0	0.0	A microcolorimetric method for the determination of inorganic phosphorus.	H H Taussky, E Shorr	J Biol Chem	1953	13061491	Yes
2970	2131	1065.5	71.58	35.8	Chronic hepatitis B: update 2009.	Anna S F Lok, Brian J McMahon	Hepatology	2009	19714720	Yes
2971	2131	1065.5	73.04	36.5	Accessories to the crime: functions of cells recruited to the tumor microenvironment.	Douglas Hanahan, Lisa M Coussens	Cancer Cell	2012	22439926	No
2972	1065	1065.0	0.0	0.0	Statistical quality control and routine data processing for radioimmunoassays and immunoradiometric assays.	D Rodbard	Clin Chem	1974	4370388	No
2973	1065	1065.0	37.13	37.1	beta-Lactamases in laboratory and clinical resistance.	D M Livermore	Clin Microbiol Rev	1995	8665470	No
2974	3195	1065.0	139.22	46.4	Multiple imputation using chained equations: Issues and guidance for practice.	Ian R White, Patrick Royston, Angela M Wood	Stat Med	2011	21225900	Yes
2975	2129	1064.5	63.79	31.9	Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report.	P Brugada, J Brugada	J Am Coll Cardiol	1992	1309182	Yes
2976	2129	1064.5	51.78	25.9	Quorum sensing in bacteria.	M B Miller, B L Bassler	Annu Rev Microbiol	2001	11544353	No
2977	1064	1064.0	31.66	31.7	The fetal and infant origins of adult disease.	D J Barker	BMJ	1990	2252919	No
2978	1064	1064.0	25.49	25.5	Neurons with graded response have collective computational properties like those of two-state neurons.	J J Hopfield	Proc Natl Acad Sci U S A	1984	6587342	Yes
2979	1064	1064.0	26.78	26.8	The Trk family of neurotrophin receptors.	M Barbacid	J Neurobiol	1994	7852993	No
2980	1064	1064.0	25.26	25.3	Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach.	Michael J Sanderson	Mol Biol Evol	2002	11752195	Yes
2981	1064	1064.0	27.15	27.1	Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.	Hiroshi Takayanagi	Nat Rev Immunol	2007	17380158	No
2982	3191	1063.7	0.0	0.0	Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells.	M Jondal, G Holm, H Wigzell	J Exp Med	1972	4114496	Yes
2983	1063	1063.0	0.0	0.0	Association of the B-cell alloantigen DRw4 with rheumatoid arthritis.	P Stastny	N Engl J Med	1978	147420	Yes
2984	1063	1063.0	24.32	24.3	The inducible transcription activator NF-kappa B: regulation by distinct protein subunits.	P A Baeuerle	Biochim Biophys Acta	1991	2018779	No
2985	1063	1063.0	43.6	43.6	Freezing of living cells: mechanisms and implications.	P Mazur	Am J Physiol	1984	6383068	No
2986	5315	1063.0	114.26	22.9	The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.	J W Harper, G R Adami, N Wei, K Keyomarsi, S J Elledge	Cell	1993	8242751	Yes
2987	1063	1063.0	19.33	19.3	Regulatory T cells in autoimmmunity*.	E M Shevach	Annu Rev Immunol	2000	10837065	No
2988	1063	1063.0	29.6	29.6	Functionalized acenes and heteroacenes for organic electronics.	John E Anthony	Chem Rev	2006	17165682	Yes
2989	2125	1062.5	70.51	35.3	Modeling and comparison of dissolution profiles.	P Costa, J M Sousa Lobo	Eur J Pharm Sci	2001	11297896	No
2990	4250	1062.5	0.0	0.0	The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.	P J Randle, P B Garland, C N Hales, E A Newsholme	Lancet	1963	13990765	Yes
2991	2124	1062.0	55.1	27.6	Statistical tests of neutrality of mutations.	Y X Fu, W H Li	Genetics	1993	8454210	Yes
2992	4247	1061.8	142.0	35.5	The cholinergic hypothesis of geriatric memory dysfunction.	R T Bartus, R L Dean, B Beer, A S Lippa	Science	1982	7046051	No
2993	4245	1061.2	87.61	21.9	Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.	L Alexopoulou, A C Holt, R Medzhitov, R A Flavell	Nature	2001	11607032	Yes
2994	1061	1061.0	0.0	0.0	Functional connections between cells as revealed by dye-coupling with a highly fluorescent naphthalimide tracer.	W W Stewart	Cell	1978	688392	Yes
2995	1061	1061.0	21.6	21.6	Coiled coils: new structures and new functions.	A Lupas	Trends Biochem Sci	1996	8918191	No
2996	1061	1061.0	21.3	21.3	The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities.	Y Yarden	Eur J Cancer	2001	11597398	No
2997	2121	1060.5	0.0	0.0	The growth of mouse bone marrow cells in vitro.	T R Bradley, D Metcalf	Aust J Exp Biol Med Sci	1966	4164182	Yes
2998	1060	1060.0	0.0	0.0	Time-dependent processes in memory storage.	J L McGaugh	Science	1966	5917768	Yes
2999	1060	1060.0	21.35	21.4	The power and the promise of DNA methylation markers.	Peter W Laird	Nat Rev Cancer	2003	12671664	No
3000	3179	1059.7	86.48	28.8	Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.	R Schreck, P Rieber, P A Baeuerle	EMBO J	1991	2065663	Yes
3001	2119	1059.5	0.0	0.0	Histochemistry of hepatic phosphatases of a physiologic pH; with special reference to the demonstration of bile canaliculi.	M Wachstein, E Meisel	Am J Clin Pathol	1957	13410831	Yes
3002	1059	1059.0	30.96	31.0	A Wilcoxon-type test for trend.	J Cuzick	Stat Med	1985	3992076	Yes
3003	1059	1059.0	33.17	33.2	The somatic marker hypothesis and the possible functions of the prefrontal cortex.	A R Damasio	Philos Trans R Soc Lond B Biol Sci	1996	8941953	No
3004	1059	1059.0	59.88	59.9	Nonalcoholic fatty liver disease: a systematic review.	Mary E Rinella	JAMA	2015	26057287	No
3005	2117	1058.5	73.95	37.0	Plasmonics for improved photovoltaic devices.	Harry A Atwater, Albert Polman	Nat Mater	2010	20168344	Yes
3006	1058	1058.0	0.0	0.0	Cell lines derived from late embryonic stages of Drosophila melanogaster.	I Schneider	J Embryol Exp Morphol	1972	4625067	Yes
3007	1058	1058.0	0.0	0.0	A comparison of canal preparations in straight and curved root canals.	S W Schneider	Oral Surg Oral Med Oral Pathol	1971	5284110	Yes
3008	1058	1058.0	30.16	30.2	Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine.	E M Tan	Adv Immunol	1982	6182766	No
3009	1058	1058.0	25.32	25.3	Selectins and their ligands: current concepts and controversies.	G S Kansas	Blood	1996	8896391	No
3010	1058	1058.0	23.4	23.4	Fluorescence spectroscopy of single biomolecules.	S Weiss	Science	1999	10073925	No
3011	6348	1058.0	164.0	27.3	Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients.	S Yusuf, P Sleight, J Pogue, J Bosch, R Davies, G Dagenais	N Engl J Med	2000	10639539	Yes
3012	1058	1058.0	25.04	25.0	G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry.	Jeffery T Davis	Angew Chem Int Ed Engl	2004	14755695	No
3013	2115	1057.5	72.55	36.3	Physiological parameters in laboratory animals and humans.	B Davies, T Morris	Pharm Res	1993	8378254	No
3014	1057	1057.0	18.85	18.9	Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism.	M S Wold	Annu Rev Biochem	1997	9242902	No
3015	2114	1057.0	51.23	25.6	Hepatitis C virus infection.	G M Lauer, B D Walker	N Engl J Med	2001	11439948	No
3016	2114	1057.0	0.0	0.0	Use of glucose oxidase, peroxidase, and O-dianisidine in determination of blood and urinary glucose.	A S Huggett, D A Nixon	Lancet	1957	13464070	Yes
3017	1057	1057.0	39.86	39.9	The amazing osteocyte.	Lynda F Bonewald	J Bone Miner Res	2011	21254230	No
3018	2113	1056.5	61.85	30.9	The acute phase response.	H Baumann, J Gauldie	Immunol Today	1994	7512342	No
3019	2113	1056.5	74.99	37.5	Pharmaceuticals and personal care products in the environment: agents of subtle change?	C G Daughton, T A Ternes	Environ Health Perspect	1999	10592150	No
3020	4225	1056.2	124.58	31.1	Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond.	Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S Vasan	Stat Med	2008	17569110	Yes
3021	2112	1056.0	0.0	0.0	The pathogenesis of atherosclerosis (first of two parts).	R Ross, J A Glomset	N Engl J Med	1976	819830	No
3022	1056	1056.0	33.89	33.9	Relations between the statistics of natural images and the response properties of cortical cells.	D J Field	J Opt Soc Am A	1987	3430225	Yes
3023	2111	1055.5	42.75	21.4	Rho GTPases: biochemistry and biology.	Aron B Jaffe, Alan Hall	Annu Rev Cell Dev Biol	2005	16212495	No
3024	2110	1055.0	0.0	0.0	Chronic catheterization of the spinal subarachnoid space.	T L Yaksh, T A Rudy	Physiol Behav	1976	14677603	Yes
3025	1055	1055.0	65.14	65.1	The brain's default mode network.	Marcus E Raichle	Annu Rev Neurosci	2015	25938726	No
3026	2109	1054.5	45.31	22.7	Mitogen-activated protein kinase pathways.	M J Robinson, M H Cobb	Curr Opin Cell Biol	1997	9069255	No
3027	4218	1054.5	106.76	26.7	C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women.	P M Ridker, C H Hennekens, J E Buring, N Rifai	N Engl J Med	2000	10733371	Yes
3028	5271	1054.2	266.04	53.2	Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee.	N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W Stitt	J Rheumatol	1988	3068365	Yes
3029	2108	1054.0	55.9	27.9	Protein oxidation in aging, disease, and oxidative stress.	B S Berlett, E R Stadtman	J Biol Chem	1997	9252331	No
3030	2108	1054.0	51.84	25.9	Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis.	Jing Yang, Robert A Weinberg	Dev Cell	2008	18539112	No
3031	2107	1053.5	44.57	22.3	Sequence logos: a new way to display consensus sequences.	T D Schneider, R M Stephens	Nucleic Acids Res	1990	2172928	Yes
3032	2107	1053.5	50.66	25.3	Shape-controlled synthesis of gold and silver nanoparticles.	Yugang Sun, Younan Xia	Science	2002	12481134	Yes
3033	2107	1053.5	49.18	24.6	Defining the role of mTOR in cancer.	David A Guertin, David M Sabatini	Cancer Cell	2007	17613433	No
3034	1053	1053.0	31.98	32.0	Analyzing the mosaic structure of genes.	J M Smith	J Mol Evol	1992	1556748	No
3035	1053	1053.0	25.75	25.8	The granulocyte-macrophage colony-stimulating factors.	D Metcalf	Science	1985	2990035	No
3036	1053	1053.0	0.0	0.0	A colorimetric method for estimating serum triglycerides.	M J Fletcher	Clin Chim Acta	1968	5696963	Yes
3037	2106	1053.0	52.68	26.3	Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival.	Josep M Llovet, Jordi Bruix	Hepatology	2003	12540794	No
3038	1053	1053.0	25.87	25.9	Evaluating medication effects outside of clinical trials: new-user designs.	Wayne A Ray	Am J Epidemiol	2003	14585769	Yes
3039	1053	1053.0	26.28	26.3	The impact of next-generation sequencing technology on genetics.	Elaine R Mardis	Trends Genet	2008	18262675	No
3040	2105	1052.5	0.0	0.0	Calcium-dependent bacteriophage DNA infection.	M Mandel, A Higa	J Mol Biol	1970	4922220	Yes
3041	2105	1052.5	63.8	31.9	Integrins in cancer: biological implications and therapeutic opportunities.	Jay S Desgrosellier, David A Cheresh	Nat Rev Cancer	2010	20029421	No
3042	1052	1052.0	29.14	29.1	T-cell growth factor.	K A Smith	Immunol Rev	1980	7000676	No
3043	1052	1052.0	24.76	24.8	Current concepts of the pathogenesis of the acute coronary syndromes.	P Libby	Circulation	2001	11457759	No
3044	1052	1052.0	21.78	21.8	VEGF and the quest for tumour angiogenesis factors.	Napoleone Ferrara	Nat Rev Cancer	2002	12360282	No
3045	1052	1052.0	23.66	23.7	Assortative mixing in networks.	M E J Newman	Phys Rev Lett	2002	12443515	Yes
3046	1052	1052.0	24.06	24.1	The enzymes, regulation, and genetics of bile acid synthesis.	David W Russell	Annu Rev Biochem	2003	12543708	No
3047	1052	1052.0	36.46	36.5	Socioeconomic status and obesity.	Lindsay McLaren	Epidemiol Rev	2007	17478442	No
3048	2104	1052.0	47.39	23.7	Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy.	S W Hell, J Wichmann	Opt Lett	1994	19844443	Yes
3049	1052	1052.0	60.95	61.0	Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial.	Kevin A Hallgren	Tutor Quant Methods Psychol	2012	22833776	Yes
3050	4207	1051.8	0.0	0.0	T cell growth factor: parameters of production and a quantitative microassay for activity.	S Gillis, M M Ferm, W Ou, K A Smith	J Immunol	1978	307029	Yes
3051	4207	1051.8	162.12	40.5	Prevalence and trends in obesity among US adults, 1999-2008.	Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R Curtin	JAMA	2010	20071471	Yes
3052	2103	1051.5	76.56	38.3	Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry.	A I Basbaum, H L Fields	Annu Rev Neurosci	1984	6143527	No
3053	1051	1051.0	21.77	21.8	The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells.	D Metcalf	Nature	1989	2469962	No
3054	1051	1051.0	0.0	0.0	The ultrastructural basis of capillary permeability studied with peroxidase as a tracer.	M J Karnovsky	J Cell Biol	1967	6061717	Yes
3055	1051	1051.0	25.65	25.6	Aptamers: an emerging class of molecules that rival antibodies in diagnostics.	S D Jayasena	Clin Chem	1999	10471678	No
3056	1051	1051.0	40.92	40.9	The role of autophagy in neurodegenerative disease.	Ralph A Nixon	Nat Med	2013	23921753	No
3057	2101	1050.5	65.94	33.0	A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data.	A Ennaceur, J Delacour	Behav Brain Res	1988	3228475	Yes
3058	2101	1050.5	65.69	32.8	Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications.	Xiaobo Chen, Samuel S Mao	Chem Rev	2007	17590053	Yes
3059	2100	1050.0	63.4	31.7	The biochemistry of P-glycoprotein-mediated multidrug resistance.	J A Endicott, V Ling	Annu Rev Biochem	1989	2570548	No
3060	2100	1050.0	41.03	20.5	Improved retroviral vectors for gene transfer and expression.	A D Miller, G J Rosman	Biotechniques	1989	2631796	Yes
3061	1050	1050.0	0.0	0.0	Lipid peroxidation damage to cell components.	A L Tappel	Fed Proc	1973	4352451	Yes
3062	1050	1050.0	39.29	39.3	Coronary physiology.	E O Feigl	Physiol Rev	1983	6296890	No
3063	2100	1050.0	44.22	22.1	A survey of telomerase activity in human cancer.	J W Shay, S Bacchetti	Eur J Cancer	1997	9282118	No
3064	1050	1050.0	23.61	23.6	ECM and cell surface proteolysis: regulating cellular ecology.	Z Werb	Cell	1997	9390552	No
3065	2100	1050.0	77.18	38.6	Modified RECIST (mRECIST) assessment for hepatocellular carcinoma.	Riccardo Lencioni, Josep M Llovet	Semin Liver Dis	2010	20175033	No
3066	2099	1049.5	49.5	24.8	The canonical Notch signaling pathway: unfolding the activation mechanism.	Raphael Kopan, Maria Xenia G Ilagan	Cell	2009	19379690	No
3067	3148	1049.3	88.32	29.4	Bacterial biofilms: from the natural environment to infectious diseases.	Luanne Hall-Stoodley, J William Costerton, Paul Stoodley	Nat Rev Microbiol	2004	15040259	No
3068	1049	1049.0	26.9	26.9	Axonal growth-associated proteins.	J H Skene	Annu Rev Neurosci	1989	2648946	No
3069	1049	1049.0	20.31	20.3	At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells.	M Kozak	J Mol Biol	1987	3681984	Yes
3070	1049	1049.0	30.93	30.9	Nitric oxide synthase structure and mechanism.	M A Marletta	J Biol Chem	1993	7685338	No
3071	1049	1049.0	25.33	25.3	Cells in stress: transcriptional activation of heat shock genes.	R I Morimoto	Science	1993	8451637	No
3072	2098	1049.0	54.01	27.0	The protective effects of estrogen on the cardiovascular system.	M E Mendelsohn, R H Karas	N Engl J Med	1999	10362825	No
3073	1049	1049.0	0.0	0.0	Fertilizing capacity of spermatozoa deposited into the fallopian tubes.	M C Chang	Nature	1951	14882325	Yes
3074	1049	1049.0	25.72	25.7	Next-generation DNA sequencing methods.	Elaine R Mardis	Annu Rev Genomics Hum Genet	2008	18576944	No
3075	1049	1049.0	50.95	51.0	Working memory: theories, models, and controversies.	Alan Baddeley	Annu Rev Psychol	2012	21961947	No
3076	2097	1048.5	45.62	22.8	The Hsp70 and Hsp60 chaperone machines.	B Bukau, A L Horwich	Cell	1998	9476895	No
3077	9436	1048.4	674.29	74.9	Cancer statistics in China, 2015.	Wanqing Chen, Rongshou Zheng, Peter D Baade, Siwei Zhang, Hongmei Zeng, Freddie Bray, Ahmedin Jemal, Xue Qin Yu, Jie He	CA Cancer J Clin	2016	26808342	Yes
3078	3145	1048.3	72.87	24.3	Adjusting batch effects in microarray expression data using empirical Bayes methods.	W Evan Johnson, Cheng Li, Ariel Rabinovic	Biostatistics	2007	16632515	Yes
3079	1048	1048.0	24.1	24.1	Pedigree disequilibrium tests for multilocus haplotypes.	Frank Dudbridge	Genet Epidemiol	2003	12916020	Yes
3080	1048	1048.0	31.67	31.7	Infection in solid-organ transplant recipients.	Jay A Fishman	N Engl J Med	2007	18094380	No
3081	4191	1047.8	0.0	0.0	Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm.	L A Papile, J Burstein, R Burstein, H Koffler	J Pediatr	1978	305471	Yes
3082	2095	1047.5	57.67	28.8	Hydrogels for tissue engineering: scaffold design variables and applications.	Jeanie L Drury, David J Mooney	Biomaterials	2003	12922147	No
3083	4189	1047.2	218.0	54.5	National Institute of Mental Health Diagnostic Interview Schedule. Its history, characteristics, and validity.	L N Robins, J E Helzer, J Croughan, K S Ratcliff	Arch Gen Psychiatry	1981	6260053	Yes
3084	1047	1047.0	0.0	0.0	Epidemiology of cancer of the colon and rectum.	D P Burkitt	Cancer	1971	5165022	Yes
3085	1047	1047.0	29.57	29.6	Determination of total protein.	G L Peterson	Methods Enzymol	1983	6855607	Yes
3086	1047	1047.0	19.65	19.6	The Pezcoller lecture: cancer cell cycles revisited.	C J Sherr	Cancer Res	2000	10919634	No
3087	3140	1046.7	81.26	27.1	Evolution and functions of long noncoding RNAs.	Chris P Ponting, Peter L Oliver, Wolf Reik	Cell	2009	19239885	No
3088	1046	1046.0	40.14	40.1	Infection by verocytotoxin-producing Escherichia coli.	M A Karmali	Clin Microbiol Rev	1989	2644022	No
3089	1046	1046.0	41.57	41.6	Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error.	J T Daugirdas	J Am Soc Nephrol	1993	8305648	Yes
3090	2092	1046.0	0.0	0.0	A modified ninhydrin reagent for the photometric determination of amino acids and related compounds.	S Moore, W H Stein	J Biol Chem	1954	13221596	Yes
3091	1046	1046.0	24.05	24.1	Version 1.2 of the Crystallography and NMR system.	Axel T Brunger	Nat Protoc	2007	18007608	Yes
3092	2091	1045.5	44.98	22.5	Plant pathogens and integrated defence responses to infection.	J L Dangl, J D Jones	Nature	2001	11459065	No
3093	6272	1045.3	198.64	33.1	Free radicals and antioxidants in normal physiological functions and human disease.	Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua Telser	Int J Biochem Cell Biol	2007	16978905	No
3094	2090	1045.0	68.73	34.4	Wine, alcohol, platelets, and the French paradox for coronary heart disease.	S Renaud, M de Lorgeril	Lancet	1992	1351198	Yes
3095	1045	1045.0	0.0	0.0	Microtubule formation in vitro in solutions containing low calcium concentrations.	R C Weisenberg	Science	1972	4626639	Yes
3096	1045	1045.0	19.92	19.9	Chronic myeloid leukemia.	C L Sawyers	N Engl J Med	1999	10219069	No
3097	1045	1045.0	24.17	24.2	The myofibroblast in wound healing and fibrocontractive diseases.	G Gabbiani	J Pathol	2003	12845617	No
3098	1045	1045.0	22.42	22.4	Liver regeneration: from myth to mechanism.	Rebecca Taub	Nat Rev Mol Cell Biol	2004	15459664	No
3099	1044	1044.0	29.75	29.8	Mitochondrial genetics: a paradigm for aging and degenerative diseases?	D C Wallace	Science	1992	1533953	Yes
3100	1044	1044.0	25.95	25.9	Plant salt tolerance.	J K Zhu	Trends Plant Sci	2001	11173290	Yes
3101	1044	1044.0	0.0	0.0	Fluorescent antibody methods.	A H Coons	Gen Cytochem Methods	1958	13574437	Yes
3102	2088	1044.0	49.26	24.6	Esophageal cancer.	Peter C Enzinger, Robert J Mayer	N Engl J Med	2003	14657432	No
3103	1044	1044.0	40.08	40.1	Synopsis of some recent tactical application of bioisosteres in drug design.	Nicholas A Meanwell	J Med Chem	2011	21413808	Yes
3104	2088	1044.0	80.48	40.2	How good are my data and what is the resolution?	Philip R Evans, Garib N Murshudov	Acta Crystallogr D Biol Crystallogr	2013	23793146	Yes
3105	2087	1043.5	52.3	26.1	Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology.	M E Feder, G E Hofmann	Annu Rev Physiol	1999	10099689	No
3106	2087	1043.5	0.0	0.0	Cortisone in ulcerative colitis; final report on a therapeutic trial.	S C Truelove, L J Witts	Br Med J	1955	13260656	Yes
3107	2086	1043.0	0.0	0.0	A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250.	J J Sedmak, S E Grossberg	Anal Biochem	1977	68686	Yes
3108	1043	1043.0	22.06	22.1	mRNA stability in mammalian cells.	J Ross	Microbiol Rev	1995	7565413	No
3109	6258	1043.0	216.11	36.0	Antioxidant activity applying an improved ABTS radical cation decolorization assay.	R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-Evans	Free Radic Biol Med	1999	10381194	Yes
3110	1043	1043.0	0.0	0.0	The Permeability Of Capillaries In Various Organs As Determined By Use Of The 'Indicator Diffusion' Method.	C Crone	Acta Physiol Scand	1963	14078649	Yes
3111	2085	1042.5	59.97	30.0	Biology of incretins: GLP-1 and GIP.	Laurie L Baggio, Daniel J Drucker	Gastroenterology	2007	17498508	No
3112	1042	1042.0	18.21	18.2	Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast.	R Rothstein	Methods Enzymol	1991	2005793	Yes
3113	1042	1042.0	34.06	34.1	Platelet-rich plasma: evidence to support its use.	Robert E Marx	J Oral Maxillofac Surg	2004	15085519	No
3114	6251	1041.8	186.18	31.0	Cancer statistics, 2007.	Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Taylor Murray, Jiaquan Xu, Michael J Thun	CA Cancer J Clin	2007	17237035	Yes
3115	2083	1041.5	77.68	38.8	Fingerprinting genomes using PCR with arbitrary primers.	J Welsh, M McClelland	Nucleic Acids Res	1990	2259619	Yes
3116	1041	1041.0	0.0	0.0	Carcinoid tumors. An analysis of 2,837 cases.	J D Godwin	Cancer	1975	1157019	Yes
3117	1041	1041.0	0.0	0.0	The epidemiologic transition. A theory of the epidemiology of population change.	A R Omran	Milbank Mem Fund Q	1971	5155251	Yes
3118	1041	1041.0	30.09	30.1	Junctional intercellular communication: the cell-to-cell membrane channel.	W R Loewenstein	Physiol Rev	1981	6270711	No
3119	1041	1041.0	19.9	19.9	The ubiquitin-proteasome pathway: on protein death and cell life.	A Ciechanover	EMBO J	1998	9857172	No
3120	1041	1041.0	28.22	28.2	The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices.	R A Jain	Biomaterials	2000	11055295	No
3121	3122	1040.7	81.22	27.1	Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm.	Y Zhang, M Brady, S Smith	IEEE Trans Med Imaging	2001	11293691	Yes
3122	2080	1040.0	51.17	25.6	Efficient isolation of genes by using antibody probes.	R A Young, R W Davis	Proc Natl Acad Sci U S A	1983	6219389	Yes
3123	1039	1039.0	0.0	0.0	Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice.	D L Coleman	Diabetologia	1978	350680	No
3124	1039	1039.0	31.72	31.7	Modeling tracer kinetics in dynamic Gd-DTPA MR imaging.	P S Tofts	J Magn Reson Imaging	1997	9039598	No
3125	2077	1038.5	48.21	24.1	Synaptic activity and the construction of cortical circuits.	L C Katz, C J Shatz	Science	1996	8895456	No
3126	6229	1038.2	210.48	35.1	A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.	Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier	Science	2012	22745249	Yes
3127	2076	1038.0	53.9	26.9	Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis.	M S Brown, J L Goldstein	Annu Rev Biochem	1983	6311077	No
3128	1038	1038.0	30.42	30.4	Pathogenetic mechanisms of septic shock.	J E Parrillo	N Engl J Med	1993	8479467	No
3129	1038	1038.0	0.0	0.0	Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig.	G D Winter	Nature	1962	14007593	Yes
3130	2075	1037.5	0.0	0.0	A simple method for the preparation of 32-P-labelled adenosine triphosphate of high specific activity.	I M Glynn, J B Chappell	Biochem J	1964	5832284	Yes
3131	2074	1037.0	102.21	51.1	Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique.	S F Dworkin, L LeResche	J Craniomandib Disord	1992	1298767	No
3132	1037	1037.0	26.93	26.9	Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system.	J P Tam	Proc Natl Acad Sci U S A	1988	3399498	Yes
3133	1037	1037.0	0.0	0.0	Cell communication, calcium ion, and cyclic adenosine monophosphate.	H Rasmussen	Science	1970	4318972	Yes
3134	1037	1037.0	41.33	41.3	Amyloid deposits and amyloidosis: the beta-fibrilloses (second of two parts).	G G Glenner	N Engl J Med	1980	6990257	No
3135	1037	1037.0	25.59	25.6	A tension-based theory of morphogenesis and compact wiring in the central nervous system.	D C Van Essen	Nature	1997	9002514	Yes
3136	1037	1037.0	35.93	35.9	Socioeconomic disadvantage and child development.	V C McLoyd	Am Psychol	1998	9491747	No
3137	1037	1037.0	35.9	35.9	Checklists for improving rigour in qualitative research: a case of the tail wagging the dog?	R S Barbour	BMJ	2001	11337448	No
3138	1037	1037.0	20.68	20.7	Focal adhesion kinase: the first ten years.	J Thomas Parsons	J Cell Sci	2003	12640026	No
3139	1037	1037.0	35.53	35.5	Persister cells.	Kim Lewis	Annu Rev Microbiol	2010	20528688	No
3140	1037	1037.0	46.42	46.4	Cytokines in inflammatory bowel disease.	Markus F Neurath	Nat Rev Immunol	2014	24751956	No
3141	1036	1036.0	21.29	21.3	Regulation of cadherin-mediated adhesion in morphogenesis.	Barry M Gumbiner	Nat Rev Mol Cell Biol	2005	16025097	No
3142	1035	1035.0	0.0	0.0	Transformation of yeast by a replicating hybrid plasmid.	J D Beggs	Nature	1978	357984	Yes
3143	2070	1035.0	53.65	26.8	Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis.	D C Schwartz, C R Cantor	Cell	1984	6373014	Yes
3144	1035	1035.0	27.55	27.6	Neuropathology of Parkinson's disease.	L S Forno	J Neuropathol Exp Neurol	1996	8786384	No
3145	2069	1034.5	50.6	25.3	A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure.	J N Cohn, G Tognoni	N Engl J Med	2001	11759645	Yes
3146	1034	1034.0	27.88	27.9	Human TH1 and TH2 subsets: doubt no more.	S Romagnani	Immunol Today	1991	1680337	Yes
3147	1034	1034.0	41.6	41.6	Geriatric Depression Scale.	J A Yesavage	Psychopharmacol Bull	1988	3249773	Yes
3148	1034	1034.0	0.0	0.0	Retention of differentiation potentialities during prolonged cultivation of myogenic cells.	D Yaffe	Proc Natl Acad Sci U S A	1968	5245982	Yes
3149	1034	1034.0	30.39	30.4	Muscarinic receptors--characterization, coupling and function.	M P Caulfield	Pharmacol Ther	1993	7504306	No
3150	1034	1034.0	29.78	29.8	Disseminating innovations in health care.	Donald M Berwick	JAMA	2003	12697800	Yes
3151	2067	1033.5	44.4	22.2	The immunoglobulin superfamily--domains for cell surface recognition.	A F Williams, A N Barclay	Annu Rev Immunol	1988	3289571	No
3152	1033	1033.0	34.91	34.9	Fever: role of pyrogens and cryogens.	M J Kluger	Physiol Rev	1991	1986393	No
3153	1033	1033.0	0.0	0.0	Quantitative Determination of Carbohydrates With Dreywood's Anthrone Reagent.	D L Morris	Science	1948	17814729	Yes
3154	1033	1033.0	0.0	0.0	A Serological Differentiation Of Human And Other Groups Of Hemolytic Streptococci.	R C Lancefield	J Exp Med	1933	19870148	Yes
3155	3096	1032.0	112.1	37.4	Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material.	P S Walsh, D A Metzger, R Higuchi	Biotechniques	1991	1867860	Yes
3156	1032	1032.0	0.0	0.0	Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse.	S Irwin	Psychopharmacologia	1968	5679627	Yes
3157	1032	1032.0	37.53	37.5	The epidemiology of adult obstructive sleep apnea.	Naresh M Punjabi	Proc Am Thorac Soc	2008	18250205	No
3158	1031	1031.0	0.0	0.0	The role of calcium in the release of neurotransmitter substances and hormones.	R P Rubin	Pharmacol Rev	1970	4322219	No
3159	1031	1031.0	23.25	23.2	Complement. Second of two parts.	M J Walport	N Engl J Med	2001	11297706	No
3160	1031	1031.0	0.0	0.0	The effect of emotion on cue utilization and the organization of behavior.	J A Easterbrook	Psychol Rev	1959	13658305	Yes
3161	1031	1031.0	30.62	30.6	A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors.	Ron Hardman	Environ Health Perspect	2006	16451849	No
3162	1031	1031.0	22.38	22.4	Protein tyrosine phosphatases: from genes, to function, to disease.	Nicholas K Tonks	Nat Rev Mol Cell Biol	2006	17057753	No
3163	4122	1030.5	84.36	21.1	Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells.	E Schreiber, P Matthias, M M Müller, W Schaffner	Nucleic Acids Res	1989	2771659	Yes
3164	2061	1030.5	47.22	23.6	Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set.	N Sreerama, R W Woody	Anal Biochem	2000	11112271	Yes
3165	3091	1030.3	0.0	0.0	Therapeutic criteria in rheumatoid arthritis.	O Steinbrocker, C H Traeger, R C Batterman	J Am Med Assoc	1949	18150288	Yes
3166	1030	1030.0	0.0	0.0	Surface modulation in cell recognition and cell growth.	G M Edelman	Science	1976	769162	No
3167	1030	1030.0	0.0	0.0	The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture.	J Cassel	Am J Epidemiol	1976	782233	No
3168	2060	1030.0	46.16	23.1	Protein-tyrosine kinases.	T Hunter, J A Cooper	Annu Rev Biochem	1985	2992362	No
3169	1030	1030.0	29.69	29.7	Transport of molecules in the tumor interstitium: a review.	R K Jain	Cancer Res	1987	3555767	No
3170	1030	1030.0	0.0	0.0	Mechanisms of lipid peroxide formation in animal tissues.	E D Wills	Biochem J	1966	5964963	Yes
3171	4120	1030.0	108.85	27.2	Real time quantitative PCR.	C A Heid, J Stevens, K J Livak, P M Williams	Genome Res	1996	8908518	Yes
3172	1030	1030.0	24.1	24.1	Toward self-organization and complex matter.	Jean-Marie Lehn	Science	2002	11923524	Yes
3173	2058	1029.0	79.26	39.6	A psychomotor stimulant theory of addiction.	R A Wise, M A Bozarth	Psychol Rev	1987	3317472	No
3174	1029	1029.0	0.0	0.0	Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.	J Ott	Am J Hum Genet	1974	4422075	Yes
3175	5145	1029.0	101.36	20.3	The protein kinase complement of the human genome.	G Manning, D B Whyte, R Martinez, T Hunter, S Sudarsanam	Science	2002	12471243	No
3176	1029	1029.0	27.81	27.8	Electrochemiluminescence (ECL).	Mark M Richter	Chem Rev	2004	15186186	No
3177	1029	1029.0	36.14	36.1	How stigma interferes with mental health care.	Patrick Corrigan	Am Psychol	2004	15491256	Yes
3178	1029	1029.0	39.72	39.7	AmpC beta-lactamases.	George A Jacoby	Clin Microbiol Rev	2009	19136439	No
3179	1029	1029.0	0.0	0.0	Connections of the cerebral cortex; the albino rat; topography of the cortical areas.	W J S Krieg	J Comp Neurol	1946	20982805	Yes
3180	3086	1028.7	73.74	24.6	Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo.	Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen	Science	2005	15831717	Yes
3181	2057	1028.5	41.14	20.6	A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli.	C S Hoffman, F Winston	Gene	1987	3319781	Yes
3182	1028	1028.0	23.54	23.5	Diffraction methods for biological macromolecules. Interactive computer graphics: FRODO.	T A Jones	Methods Enzymol	1985	3841179	Yes
3183	1028	1028.0	32.19	32.2	Inferring microstructural features and the physiological state of tissues from diffusion-weighted images.	P J Basser	NMR Biomed	1995	8739270	No
3184	1028	1028.0	37.19	37.2	Density matrix formulation for quantum renormalization groups.	White	Phys Rev Lett	1992	10046608	Yes
3185	1028	1028.0	29.93	29.9	Persister cells, dormancy and infectious disease.	Kim Lewis	Nat Rev Microbiol	2007	17143318	No
3186	2055	1027.5	65.83	32.9	Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC).	Kathryn M Connor, Jonathan R T Davidson	Depress Anxiety	2003	12964174	Yes
3187	5136	1027.2	162.19	32.4	Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure.	Salim Yusuf, Bertram Pitt, Clarence E Davis, William B Hood, Jay N Cohn	N Engl J Med	1991	2057034	Yes
3188	1027	1027.0	26.75	26.8	Two-stage model of memory trace formation: a role for "noisy" brain states.	G Buzsáki	Neuroscience	1989	2687720	No
3189	2054	1027.0	61.38	30.7	Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation.	J M Reul, E R de Kloet	Endocrinology	1985	2998738	Yes
3190	3081	1027.0	80.54	26.8	Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).	R S Spielman, R E McGinnis, W J Ewens	Am J Hum Genet	1993	8447318	Yes
3191	2054	1027.0	39.96	20.0	Wnt signaling: a common theme in animal development.	K M Cadigan, R Nusse	Genes Dev	1997	9407023	No
3192	1027	1027.0	0.0	0.0	A production of amino acids under possible primitive earth conditions.	S L Miller	Science	1953	13056598	Yes
3193	1027	1027.0	35.74	35.7	phangorn: phylogenetic analysis in R.	Klaus Peter Schliep	Bioinformatics	2011	21169378	Yes
3194	1026	1026.0	43.29	43.3	Toward terminological, conceptual, and statistical clarity in the study of mediators and moderators: examples from the child-clinical and pediatric psychology literatures.	G N Holmbeck	J Consult Clin Psychol	1997	9256561	Yes
3195	1026	1026.0	19.11	19.1	Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions.	W Kolch	Biochem J	2000	11023813	No
3196	1026	1026.0	20.05	20.1	Biological robustness.	Hiroaki Kitano	Nat Rev Genet	2004	15520792	No
3197	1026	1026.0	39.51	39.5	Volumetric modulated arc therapy: IMRT in a single gantry arc.	Karl Otto	Med Phys	2008	18293586	Yes
3198	2052	1026.0	51.59	25.8	Next-generation DNA sequencing.	Jay Shendure, Hanlee Ji	Nat Biotechnol	2008	18846087	Yes
3199	2051	1025.5	53.33	26.7	The regulation and function of c-fos and other immediate early genes in the nervous system.	M Sheng, M E Greenberg	Neuron	1990	1969743	No
3200	2051	1025.5	62.66	31.3	Physiological time-series analysis using approximate entropy and sample entropy.	J S Richman, J R Moorman	Am J Physiol Heart Circ Physiol	2000	10843903	Yes
3201	2051	1025.5	87.62	43.8	PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data.	Daniel R Roe, Thomas E Cheatham	J Chem Theory Comput	2013	26583988	Yes
3202	2051	1025.5	138.22	69.1	The amyloid hypothesis of Alzheimer's disease at 25 years.	Dennis J Selkoe, John Hardy	EMBO Mol Med	2016	27025652	No
3203	1025	1025.0	55.9	55.9	The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation.	G A Ilizarov	Clin Orthop Relat Res	1989	2910611	Yes
3204	1025	1025.0	23.29	23.3	Molecular imaging of cancer with positron emission tomography.	Sanjiv Sam Gambhir	Nat Rev Cancer	2002	12209157	No
3205	1025	1025.0	29.55	29.6	Thermo- and pH-responsive polymers in drug delivery.	Dirk Schmaljohann	Adv Drug Deliv Rev	2006	17125884	No
3206	2050	1025.0	52.12	26.1	Cell cycle, CDKs and cancer: a changing paradigm.	Marcos Malumbres, Mariano Barbacid	Nat Rev Cancer	2009	19238148	No
3207	1024	1024.0	18.88	18.9	Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation.	Eric C Lai	Nat Genet	2002	11896390	Yes
3208	2048	1024.0	0.0	0.0	Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran.	R R Guillard, J H Ryther	Can J Microbiol	1962	13902807	Yes
3209	3072	1024.0	123.24	41.1	Hepatocellular carcinoma.	Alejandro Forner, Josep M Llovet, Jordi Bruix	Lancet	2012	22353262	No
3210	2047	1023.5	58.44	29.2	EasySpin, a comprehensive software package for spectral simulation and analysis in EPR.	Stefan Stoll, Arthur Schweiger	J Magn Reson	2006	16188474	Yes
3211	3070	1023.3	102.13	34.0	Qualitative research in health care. Analysing qualitative data.	C Pope, S Ziebland, N Mays	BMJ	2000	10625273	No
3212	1023	1023.0	0.0	0.0	Tests for emotionality in rats and mice: a review.	J Archer	Anim Behav	1973	4578750	No
3213	1023	1023.0	0.0	0.0	The influence of immunologically committed lymphoid cells on macrophage activity in vivo.	G B Mackaness	J Exp Med	1969	4976110	Yes
3214	1023	1023.0	36.22	36.2	A review of psychological risk factors in back and neck pain.	S J Linton	Spine (Phila Pa 1976)	2000	10788861	No
3215	1023	1023.0	20.2	20.2	Progress in human tumour immunology and immunotherapy.	S A Rosenberg	Nature	2001	11357146	No
3216	1023	1023.0	0.0	0.0	Regional blood flow by fractional distribution of indicators.	L A Sapirstein	Am J Physiol	1958	13521003	Yes
3217	1023	1023.0	45.87	45.9	The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults.	L S Radloff	J Youth Adolesc	1991	24265004	Yes
3218	1023	1023.0	0.0	0.0	Cell deaths in normal vertebrate ontogeny.	A Glucksmann	Biol Rev Camb Philos Soc	1951	24540363	Yes
3219	1022	1022.0	23.88	23.9	Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system.	T Ikemura	J Mol Biol	1981	6175758	Yes
3220	1022	1022.0	18.27	18.3	Molecular mechanisms of axon guidance.	Barry J Dickson	Science	2002	12471249	No
3221	2043	1021.5	53.75	26.9	Hydrogels for tissue engineering.	K Y Lee, D J Mooney	Chem Rev	2001	11710233	No
3222	2043	1021.5	64.69	32.3	Toll-like receptors and their crosstalk with other innate receptors in infection and immunity.	Taro Kawai, Shizuo Akira	Immunity	2011	21616434	No
3223	1021	1021.0	26.78	26.8	Tumour necrosis factor and cancer.	Frances Balkwill	Nat Rev Cancer	2009	19343034	No
3224	2041	1020.5	64.43	32.2	Tumor metastasis: molecular insights and evolving paradigms.	Scott Valastyan, Robert A Weinberg	Cell	2011	22000009	No
3225	1020	1020.0	0.0	0.0	Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system.	U Ungerstedt	Acta Physiol Scand Suppl	1971	4332694	Yes
3226	1020	1020.0	28.82	28.8	Synchronization of cortical activity and its putative role in information processing and learning.	W Singer	Annu Rev Physiol	1993	8466179	No
3227	1020	1020.0	38.62	38.6	Tumor delivery of macromolecular drugs based on the EPR effect.	Vladimir Torchilin	Adv Drug Deliv Rev	2011	20304019	No
3228	2039	1019.5	42.44	21.2	IAP family proteins--suppressors of apoptosis.	Q L Deveraux, J C Reed	Genes Dev	1999	9990849	No
3229	1019	1019.0	0.0	0.0	The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle.	M Jouvet	Ergeb Physiol	1972	4403272	Yes
3230	2038	1019.0	36.76	18.4	Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain.	W Gu, R G Roeder	Cell	1997	9288740	Yes
3231	1019	1019.0	30.48	30.5	The pollution of the marine environment by plastic debris: a review.	José G B Derraik	Mar Pollut Bull	2002	12405208	No
3232	2038	1019.0	56.96	28.5	Morris water maze: procedures for assessing spatial and related forms of learning and memory.	Charles V Vorhees, Michael T Williams	Nat Protoc	2006	17406317	Yes
3233	4074	1018.5	153.98	38.5	Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials.	K F Schulz, I Chalmers, R J Hayes, D G Altman	JAMA	1995	7823387	Yes
3234	1018	1018.0	38.26	38.3	Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants.	R W Bohannon	Age Ageing	1997	9143432	Yes
3235	1018	1018.0	24.05	24.1	The columnar organization of the neocortex.	V B Mountcastle	Brain	1997	9153131	No
3236	1018	1018.0	23.32	23.3	Molecular mechanisms of myocardial remodeling.	B Swynghedauw	Physiol Rev	1999	9922372	No
3237	1018	1018.0	26.06	26.1	Context and behavioral processes in extinction.	Mark E Bouton	Learn Mem	2004	15466298	No
3238	1018	1018.0	22.78	22.8	Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution.	Sean B Carroll	Cell	2008	18614008	Yes
3239	1017	1017.0	32.3	32.3	MOPAC: a semiempirical molecular orbital program.	J J Stewart	J Comput Aided Mol Des	1990	2197373	No
3240	1017	1017.0	29.28	29.3	Hepatitis B virus. The major etiology of hepatocellular carcinoma.	R P Beasley	Cancer	1988	2834034	No
3241	1017	1017.0	54.01	54.0	The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction.	G A Ilizarov	Clin Orthop Relat Res	1989	2912628	Yes
3242	1017	1017.0	0.0	0.0	Simplified Myeloperoxidase Stain Using Benzidine Dihydrochloride.	L S Kaplow	Blood	1965	14332483	Yes
3243	1017	1017.0	0.0	0.0	The stereotaxic method and radiosurgery of the brain.	L Leksell	Acta Chir Scand	1951	14914373	Yes
3244	1017	1017.0	23.86	23.9	How neutrophils kill microbes.	Anthony W Segal	Annu Rev Immunol	2005	15771570	No
3245	1017	1017.0	33.13	33.1	Electrochemical glucose biosensors.	Joseph Wang	Chem Rev	2008	18154363	No
3246	3049	1016.3	79.55	26.5	Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions.	M Piotto, V Saudek, V Sklenár	J Biomol NMR	1992	1490109	Yes
3247	2032	1016.0	73.46	36.7	Social conditions as fundamental causes of disease.	B G Link, J Phelan	J Health Soc Behav	1995	7560851	No
3248	1016	1016.0	28.47	28.5	Prostaglandin synthase 2.	H R Herschman	Biochim Biophys Acta	1996	8555245	No
3249	1016	1016.0	30.09	30.1	Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review.	John W Newcomer	CNS Drugs	2005	15998156	No
3250	2031	1015.5	56.2	28.1	Chlorophyll fluorescence--a practical guide.	K Maxwell, G N Johnson	J Exp Bot	2000	10938857	No
3251	1015	1015.0	55.64	55.6	A "rationalized" arcsine transform.	G A Studebaker	J Speech Hear Res	1985	4046587	Yes
3252	1015	1015.0	45.98	46.0	Coping theory and research: past, present, and future.	R S Lazarus	Psychosom Med	1993	8346332	No
3253	1015	1015.0	28.51	28.5	Presynaptic nicotinic ACh receptors.	S Wonnacott	Trends Neurosci	1997	9023878	No
3254	2030	1015.0	53.78	26.9	Principles of bioactive lipid signalling: lessons from sphingolipids.	Yusuf A Hannun, Lina M Obeid	Nat Rev Mol Cell Biol	2008	18216770	No
3255	6085	1014.2	166.85	27.8	Prediction of coronary heart disease using risk factor categories.	P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B Kannel	Circulation	1998	9603539	Yes
3256	1014	1014.0	37.36	37.4	Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes.	M A Lemp	CLAO J	1995	8565190	No
3257	1014	1014.0	25.0	25.0	P-450 metabolites of arachidonic acid in the control of cardiovascular function.	Richard J Roman	Physiol Rev	2002	11773611	No
3258	8108	1013.5	255.58	31.9	The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment.	Ziad S Nasreddine, Natalie A Phillips, Valérie Bédirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard Chertkow	J Am Geriatr Soc	2005	15817019	Yes
3259	2027	1013.5	99.22	49.6	Alginate: properties and biomedical applications.	Kuen Yong Lee, David J Mooney	Prog Polym Sci	2012	22125349	Yes
3260	1013	1013.0	29.64	29.6	Animal mitochondrial DNA: structure and evolution.	D R Wolstenholme	Int Rev Cytol	1992	1452431	No
3261	1013	1013.0	50.27	50.3	Analysis of Fickian and non-Fickian drug release from polymers.	N A Peppas	Pharm Acta Helv	1985	4011621	Yes
3262	1013	1013.0	21.07	21.1	Resolution of phase ambiguity in macromolecular crystallography.	B C Wang	Methods Enzymol	1985	4079800	Yes
3263	1013	1013.0	29.6	29.6	Limbic-cortical dysregulation: a proposed model of depression.	H S Mayberg	J Neuropsychiatry Clin Neurosci	1997	9276848	No
3264	1013	1013.0	21.84	21.8	Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution.	Z Yang	Mol Biol Evol	1998	9580986	Yes
3265	1013	1013.0	24.1	24.1	Natural history of chronic hepatitis C.	Leonard B Seeff	Hepatology	2002	12407575	No
3266	1013	1013.0	31.43	31.4	The Hospital Anxiety And Depression Scale.	R Philip Snaith	Health Qual Life Outcomes	2003	12914662	Yes
3267	1013	1013.0	30.77	30.8	Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis.	P Vestergaard	Osteoporos Int	2007	17068657	No
3268	1013	1013.0	31.02	31.0	Stronger Brønsted acids.	Takahiko Akiyama	Chem Rev	2007	17983247	Yes
3269	2026	1013.0	51.76	25.9	Modes of resistance to anti-angiogenic therapy.	Gabriele Bergers, Douglas Hanahan	Nat Rev Cancer	2008	18650835	No
3270	1013	1013.0	34.09	34.1	Deconvoluting the context-dependent role for autophagy in cancer.	Eileen White	Nat Rev Cancer	2012	22534666	No
3271	1012	1012.0	22.14	22.1	Potential metal-binding domains in nucleic acid binding proteins.	J M Berg	Science	1986	2421409	Yes
3272	1012	1012.0	31.78	31.8	Unstable angina with fatal outcome: dynamic coronary thrombosis leading to infarction and/or sudden death. Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion.	E Falk	Circulation	1985	3971539	Yes
3273	1012	1012.0	32.28	32.3	Selective modification of glutathione metabolism.	A Meister	Science	1983	6836290	Yes
3274	1012	1012.0	28.05	28.1	Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity.	F P Guengerich	Chem Res Toxicol	2001	11409933	No
3275	1012	1012.0	27.9	27.9	Recent advances in neuroblastoma.	John M Maris	N Engl J Med	2010	20558371	No
3276	2023	1011.5	42.05	21.0	Tumour-cell invasion and migration: diversity and escape mechanisms.	Peter Friedl, Katarina Wolf	Nat Rev Cancer	2003	12724734	No
3277	2022	1011.0	77.14	38.6	Visual search and stimulus similarity.	J Duncan, G W Humphreys	Psychol Rev	1989	2756067	Yes
3278	4044	1011.0	136.24	34.1	Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin.	W Vale, J Spiess, C Rivier, J Rivier	Science	1981	6267699	Yes
3279	1011	1011.0	25.1	25.1	Quantification of beta-sheet amyloid fibril structures with thioflavin T.	H LeVine	Methods Enzymol	1999	10507030	Yes
3280	2022	1011.0	43.15	21.6	Genomic control for association studies.	B Devlin, K Roeder	Biometrics	1999	11315092	Yes
3281	3033	1011.0	88.44	29.5	Methods in mammalian autophagy research.	Noboru Mizushima, Tamotsu Yoshimori, Beth Levine	Cell	2010	20144757	Yes
3282	8081	1010.1	322.95	40.4	Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey.	R C Kessler, K A McGonagle, S Zhao, C B Nelson, M Hughes, S Eshleman, H U Wittchen, K S Kendler	Arch Gen Psychiatry	1994	8279933	Yes
3283	1010	1010.0	0.0	0.0	Isolation of an organ specific protein antigen from cell-surface membrane of rat liver.	D M Neville	Biochim Biophys Acta	1968	4967807	Yes
3284	1010	1010.0	53.75	53.8	Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem.	P D Henry	Am J Cardiol	1980	6255787	No
3285	1010	1010.0	23.81	23.8	Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis.	Tirion	Phys Rev Lett	1996	10063201	Yes
3286	1010	1010.0	23.34	23.3	New ideas about atrial fibrillation 50 years on.	Stanley Nattel	Nature	2002	11805846	No
3287	1010	1010.0	21.18	21.2	mTOR and cancer: insights into a complex relationship.	David M Sabatini	Nat Rev Cancer	2006	16915295	No
3288	3029	1009.7	144.63	48.2	Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines.	F Guillemin, C Bombardier, D Beaton	J Clin Epidemiol	1993	8263569	No
3289	1009	1009.0	52.66	52.7	The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury.	J A Koufman	Laryngoscope	1991	1895864	No
3290	1009	1009.0	0.0	0.0	Presidental address. Neuropathological aspects of brain edema.	I Klatzo	J Neuropathol Exp Neurol	1967	5336776	No
3291	2018	1009.0	54.51	27.3	Compilation and analysis of Escherichia coli promoter DNA sequences.	D K Hawley, W R McClure	Nucleic Acids Res	1983	6344016	No
3292	1009	1009.0	33.29	33.3	Peritonectomy procedures.	P H Sugarbaker	Ann Surg	1995	7826158	Yes
3293	1009	1009.0	0.0	0.0	A Protection Motivation Theory of Fear Appeals and Attitude Change1.	Ronald W Rogers	J Psychol	1975	28136248	Yes
3294	1008	1008.0	28.98	29.0	Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease.	W J Welch	Physiol Rev	1992	1438579	No
3295	1008	1008.0	22.43	22.4	Microsatellites: simple sequences with complex evolution.	Hans Ellegren	Nat Rev Genet	2004	15153996	No
3296	1008	1008.0	0.0	0.0	The Stability of Broken Ends of Chromosomes in Zea Mays.	B McClintock	Genetics	1941	17247004	Yes
3297	3023	1007.7	90.99	30.3	Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion.	Robert D Schreiber, Lloyd J Old, Mark J Smyth	Science	2011	21436444	No
3298	2015	1007.5	0.0	0.0	Role of cell shape in growth control.	J Folkman, A Moscona	Nature	1978	661946	Yes
3299	3021	1007.0	0.0	0.0	Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose.	P L Ey, S J Prowse, C R Jenkin	Immunochemistry	1978	30693	Yes
3300	3020	1006.7	62.4	20.8	The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.	W H Landschulz, P F Johnson, S L McKnight	Science	1988	3289117	Yes
3301	5033	1006.6	206.0	41.2	The hallmarks of aging.	Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer	Cell	2013	23746838	No
3302	1006	1006.0	35.5	35.5	Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance.	M D Majewska	Prog Neurobiol	1992	1349441	No
3303	1006	1006.0	28.15	28.1	The role of protein phosphorylation in neural and hormonal control of cellular activity.	P Cohen	Nature	1982	6280056	No
3304	1006	1006.0	25.92	25.9	Mode of action of membrane active antimicrobial peptides.	Yechiel Shai	Biopolymers	2002	12491537	No
3305	1006	1006.0	31.78	31.8	Species concepts and species delimitation.	Kevin De Queiroz	Syst Biol	2007	18027281	Yes
3306	2012	1006.0	48.52	24.3	Blinded by the Light: The Growing Complexity of p53.	Karen H Vousden, Carol Prives	Cell	2009	19410540	No
3307	1005	1005.0	34.89	34.9	Lipid peroxidation and antioxidants as biomarkers of tissue damage.	J M Gutteridge	Clin Chem	1995	7497639	No
3308	1005	1005.0	22.6	22.6	Epstein-Barr virus infection.	J I Cohen	N Engl J Med	2000	10944566	No
3309	1005	1005.0	27.97	28.0	The emotional dog and its rational tail: a social intuitionist approach to moral judgment.	J Haidt	Psychol Rev	2001	11699120	Yes
3310	1005	1005.0	22.02	22.0	Oxidant signals and oxidative stress.	Toren Finkel	Curr Opin Cell Biol	2003	12648682	No
3311	1005	1005.0	22.9	22.9	Phenotypic plasticity and the epigenetics of human disease.	Andrew P Feinberg	Nature	2007	17522677	No
3312	6029	1004.8	194.4	32.4	Prevalence of overweight and obesity in the United States, 1999-2004.	Cynthia L Ogden, Margaret D Carroll, Lester R Curtin, Margaret A McDowell, Carolyn J Tabak, Katherine M Flegal	JAMA	2006	16595758	Yes
3313	3014	1004.7	61.26	20.4	Genetic instabilities in human cancers.	C Lengauer, K W Kinzler, B Vogelstein	Nature	1998	9872311	No
3314	3013	1004.3	157.53	52.5	Assessing coping strategies: a theoretically based approach.	C S Carver, M F Scheier, J K Weintraub	J Pers Soc Psychol	1989	2926629	Yes
3315	1004	1004.0	17.47	17.5	Functional inactivation of genes by dominant negative mutations.	I Herskowitz	Nature	1987	2442619	No
3316	1004	1004.0	0.0	0.0	Vagal sensory receptors and their reflex effects.	A S Paintal	Physiol Rev	1973	4568412	No
3317	4015	1003.8	0.0	0.0	Coated charcoal immunoassay of insulin.	V Herbert, K S Lau, C W Gottlieb, S J Bleicher	J Clin Endocrinol Metab	1965	5320561	Yes
3318	4014	1003.5	105.56	26.4	A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V.	I Vermes, C Haanen, H Steffens-Nakken, C Reutelingsperger	J Immunol Methods	1995	7622868	Yes
3319	2007	1003.5	62.5	31.2	Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio.	Aluísio J D Barros, Vânia N Hirakata	BMC Med Res Methodol	2003	14567763	Yes
3320	1003	1003.0	26.92	26.9	The potential environmental impact of engineered nanomaterials.	Vicki L Colvin	Nat Biotechnol	2003	14520401	Yes
3321	1003	1003.0	25.03	25.0	Anatomy and regulation of the central melanocortin system.	Roger D Cone	Nat Neurosci	2005	15856065	No
3322	1003	1003.0	0.0	0.0	Histological and histochemical uses of periodic acid.	J F A McMANUS	Stain Technol	1948	18867618	Yes
3323	2005	1002.5	0.0	0.0	Analysis of probability as an aid in the clinical diagnosis of coronary-artery disease.	G A Diamond, J S Forrester	N Engl J Med	1979	440357	Yes
3324	2005	1002.5	76.24	38.1	The Modified Mini-Mental State (3MS) examination.	E L Teng, H C Chui	J Clin Psychiatry	1987	3611032	Yes
3325	1002	1002.0	34.53	34.5	Why we need observational studies to evaluate the effectiveness of health care.	N Black	BMJ	1996	8634569	Yes
3326	2004	1002.0	60.36	30.2	The capacity of visual working memory for features and conjunctions.	S J Luck, E K Vogel	Nature	1997	9384378	Yes
3327	2004	1002.0	46.55	23.3	Obesity and insulin resistance.	B B Kahn, J S Flier	J Clin Invest	2000	10953022	No
3328	1002	1002.0	21.08	21.1	Telomeres and human disease: ageing, cancer and beyond.	Maria A Blasco	Nat Rev Genet	2005	16136653	No
3329	3005	1001.7	0.0	0.0	Depression: a new animal model sensitive to antidepressant treatments.	R D Porsolt, M Le Pichon, M Jalfre	Nature	1977	559941	Yes
3330	2003	1001.5	52.83	26.4	Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2.	M Tsujii, R N DuBois	Cell	1995	8521479	Yes
3331	1001	1001.0	28.44	28.4	Intermediate filaments: a chemically heterogeneous, developmentally regulated class of proteins.	E Lazarides	Annu Rev Biochem	1982	6180679	No
3332	1001	1001.0	33.92	33.9	A practical computer-based approach to the analysis of radioligand binding experiments.	G A McPherson	Comput Programs Biomed	1983	6319079	Yes
3333	1001	1001.0	47.52	47.5	α-band oscillations, attention, and controlled access to stored information.	Wolfgang Klimesch	Trends Cogn Sci	2012	23141428	No
3334	3002	1000.7	65.0	21.7	TGF-beta signalling from cell membrane to nucleus through SMAD proteins.	C H Heldin, K Miyazono, P ten Dijke	Nature	1997	9393997	No
3335	2001	1000.5	47.17	23.6	Cellular uptake of the tat protein from human immunodeficiency virus.	A D Frankel, C O Pabo	Cell	1988	2849510	Yes
3336	2001	1000.5	40.44	20.2	The druggable genome.	Andrew L Hopkins, Colin R Groom	Nat Rev Drug Discov	2002	12209152	No
3337	1000	1000.0	25.84	25.8	Molten globule and protein folding.	O B Ptitsyn	Adv Protein Chem	1995	8561052	No
3338	1000	1000.0	21.32	21.3	Osmotic stress signaling and osmoadaptation in yeasts.	Stefan Hohmann	Microbiol Mol Biol Rev	2002	12040128	No
3339	1000	1000.0	0.0	0.0	Motivation reconsidered: the concept of competence.	R W White	Psychol Rev	1959	13844397	Yes
3340	1000	1000.0	34.03	34.0	Understanding diagnostic tests 3: Receiver operating characteristic curves.	Anthony K Akobeng	Acta Paediatr	2007	17376185	No
3341	1000	1000.0	0.0	0.0	Differential spectrophotometry of purine compounds by means of specific enzymes; determination of hydroxypurine compounds.	H M Kalckar	J Biol Chem	1947	20285039	Yes
3342	999	999.0	38.47	38.5	The ovariectomized rat model of postmenopausal bone loss.	D N Kalu	Bone Miner	1991	1773131	No
3343	999	999.0	29.58	29.6	Cytochrome oxidase: an endogenous metabolic marker for neuronal activity.	M T Wong-Riley	Trends Neurosci	1989	2469224	No
3344	999	999.0	29.54	29.5	Classes of calcium channels in vertebrate cells.	B P Bean	Annu Rev Physiol	1989	2540697	No
3345	999	999.0	36.97	37.0	Thermal properties of graphene and nanostructured carbon materials.	Alexander A Balandin	Nat Mater	2011	21778997	Yes
3346	999	999.0	36.43	36.4	Apoptosis in cancer: from pathogenesis to treatment.	Rebecca S Y Wong	J Exp Clin Cancer Res	2011	21943236	No
3347	998	998.0	33.6	33.6	MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship.	Amy E Pasquinelli	Nat Rev Genet	2012	22411466	No
3348	1995	997.5	80.52	40.3	Functional interactions between the gut microbiota and host metabolism.	Valentina Tremaroli, Fredrik Bäckhed	Nature	2012	22972297	No
3349	2992	997.3	98.05	32.7	Health benefits of physical activity: the evidence.	Darren E R Warburton, Crystal Whitney Nicol, Shannon S D Bredin	CMAJ	2006	16534088	No
3350	997	997.0	0.0	0.0	Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address.	E C Miller	Cancer Res	1978	348302	No
3351	997	997.0	23.14	23.1	Telomere loss: mitotic clock or genetic time bomb?	C B Harley	Mutat Res	1991	1722017	No
3352	1994	997.0	84.32	42.2	Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications.	L A Clark, D Watson	J Abnorm Psychol	1991	1918611	No
3353	1994	997.0	91.08	45.5	Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics.	J B Mulliken, J Glowacki	Plast Reconstr Surg	1982	7063565	Yes
3354	997	997.0	25.18	25.2	Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures.	Frank Würthner	Chem Commun (Camb)	2004	15263926	Yes
3355	997	997.0	44.48	44.5	What is self-rated health and why does it predict mortality? Towards a unified conceptual model.	Marja Jylhä	Soc Sci Med	2009	19520474	Yes
3356	4984	996.8	103.9	20.8	Electrostatics of nanosystems: application to microtubules and the ribosome.	N A Baker, D Sept, S Joseph, M J Holst, J A McCammon	Proc Natl Acad Sci U S A	2001	11517324	Yes
3357	996	996.0	0.0	0.0	Serine proteases: structure and mechanism of catalysis.	J Kraut	Annu Rev Biochem	1977	332063	No
3358	996	996.0	27.32	27.3	The molecular biology and functions of the granulocyte-macrophage colony-stimulating factors.	D Metcalf	Blood	1986	3002522	No
3359	996	996.0	26.0	26.0	Automatic quantitation of localized in vivo 1H spectra with LCModel.	S W Provencher	NMR Biomed	2001	11410943	Yes
3360	996	996.0	24.45	24.4	Personal genomes: The case of the missing heritability.	Brendan Maher	Nature	2008	18987709	No
3361	1992	996.0	55.01	27.5	Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm.	Subhra K Biswas, Alberto Mantovani	Nat Immunol	2010	20856220	No
3362	1991	995.5	50.94	25.5	ZINC--a free database of commercially available compounds for virtual screening.	John J Irwin, Brian K Shoichet	J Chem Inf Model	2005	15667143	Yes
3363	10949	995.4	327.97	29.8	The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data.	Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristo	Genome Res	2010	20644199	Yes
3364	995	995.0	19.47	19.5	DNA methylation in cancer: too much, but also too little.	Melanie Ehrlich	Oncogene	2002	12154403	No
3365	994	994.0	48.55	48.5	Resilience in the face of adversity. Protective factors and resistance to psychiatric disorder.	M Rutter	Br J Psychiatry	1985	3830321	Yes
3366	994	994.0	40.94	40.9	Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin.	R J Cousins	Physiol Rev	1985	3885271	No
3367	1988	994.0	59.16	29.6	Glycoprotein hormones: structure and function.	J G Pierce, T F Parsons	Annu Rev Biochem	1981	6267989	No
3368	994	994.0	56.77	56.8	Calcium phosphate ceramics as hard tissue prosthetics.	M Jarcho	Clin Orthop Relat Res	1981	7018783	No
3369	994	994.0	36.31	36.3	Methods for dealing with reaction time outliers.	R Ratcliff	Psychol Bull	1993	8272468	Yes
3370	6954	993.4	212.39	30.3	Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.	H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E Marsh	Stroke	1993	7678184	Yes
3371	1986	993.0	47.51	23.8	p53 function and dysfunction.	B Vogelstein, K W Kinzler	Cell	1992	1505019	No
3372	993	993.0	49.53	49.5	Self-discrepancy: a theory relating self and affect.	E T Higgins	Psychol Rev	1987	3615707	Yes
3373	3972	993.0	98.03	24.5	MEGA2: molecular evolutionary genetics analysis software.	S Kumar, K Tamura, I B Jakobsen, M Nei	Bioinformatics	2001	11751241	Yes
3374	993	993.0	0.0	0.0	Histiocytosis X; integration of eosinophilic granuloma of bone, Letterer-Siwe disease, and Schüller-Christian disease as related manifestations of a single nosologic entity.	L Lichtenstein	AMA Arch Pathol	1953	13057466	Yes
3375	1984	992.0	0.0	0.0	A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants.	G C Liggins, R N Howie	Pediatrics	1972	4561295	Yes
3376	1984	992.0	0.0	0.0	The period of susceptibility to the physiological effects of unilateral eye closure in kittens.	D H Hubel, T N Wiesel	J Physiol	1970	5498493	Yes
3377	1984	992.0	0.0	0.0	Fine structural localization of a blood-brain barrier to exogenous peroxidase.	T S Reese, M J Karnovsky	J Cell Biol	1967	6033532	Yes
3378	992	992.0	23.87	23.9	The prefrontal cortex--an update: time is of the essence.	J M Fuster	Neuron	2001	11394996	No
3379	2976	992.0	73.09	24.4	Photodynamic therapy for cancer.	Dennis E J G J Dolmans, Dai Fukumura, Rakesh K Jain	Nat Rev Cancer	2003	12724736	No
3380	4955	991.0	152.61	30.5	The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells.	R Moll, W W Franke, D L Schiller, B Geiger, R Krepler	Cell	1982	6186379	No
3381	2973	991.0	83.17	27.7	A nonparametric method for automatic correction of intensity nonuniformity in MRI data.	J G Sled, A P Zijdenbos, A C Evans	IEEE Trans Med Imaging	1998	9617910	Yes
3382	1982	991.0	48.16	24.1	Regulation of wound healing by growth factors and cytokines.	Sabine Werner, Richard Grose	Physiol Rev	2003	12843410	No
3383	991	991.0	24.58	24.6	Nonaqueous liquid electrolytes for lithium-based rechargeable batteries.	Kang Xu	Chem Rev	2004	15669157	Yes
3384	2972	990.7	73.7	24.6	Nitric oxide and macrophage function.	J MacMicking, Q W Xie, C Nathan	Annu Rev Immunol	1997	9143691	No
3385	1981	990.5	37.42	18.7	Signal transduction by lymphocyte antigen receptors.	A Weiss, D R Littman	Cell	1994	8293463	No
3386	1981	990.5	40.05	20.0	Cellular functions regulated by Src family kinases.	S M Thomas, J S Brugge	Annu Rev Cell Dev Biol	1997	9442882	No
3387	990	990.0	27.82	27.8	Epidemiology of women and depression.	Ronald C Kessler	J Affect Disord	2003	12646294	Yes
3388	990	990.0	0.0	0.0	Pelvic Scoring For Elective Induction.	E H Bishop	Obstet Gynecol	1964	14199536	Yes
3389	990	990.0	22.35	22.4	Up on the tightrope: natural killer cell activation and inhibition.	Lewis L Lanier	Nat Immunol	2008	18425106	No
3390	6928	989.7	186.29	26.6	Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.	R K Saiki, S Scharf, F Faloona, K B Mullis, G T Horn, H A Erlich, N Arnheim	Science	1985	2999980	Yes
3391	3958	989.5	94.72	23.7	The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis.	R M Kluck, E Bossy-Wetzel, D R Green, D D Newmeyer	Science	1997	9027315	Yes
3392	1979	989.5	44.79	22.4	Caspases: killer proteases.	D W Nicholson, N A Thornberry	Trends Biochem Sci	1997	9270303	No
3393	5937	989.5	158.19	26.4	Ghrelin is a growth-hormone-releasing acylated peptide from stomach.	M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K Kangawa	Nature	1999	10604470	Yes
3394	1979	989.5	0.0	0.0	Maximum utilization of the life table method in analyzing survival.	S J Cutler, F Ederer	J Chronic Dis	1958	13598782	Yes
3395	1979	989.5	64.81	32.4	Health effects of fine particulate air pollution: lines that connect.	C Arden Pope, Douglas W Dockery	J Air Waste Manag Assoc	2006	16805397	No
3396	7915	989.4	232.8	29.1	A method and server for predicting damaging missense mutations.	Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R Sunyaev	Nat Methods	2010	20354512	Yes
3397	989	989.0	28.7	28.7	Advanced protein glycosylation in diabetes and aging.	M Brownlee	Annu Rev Med	1995	7598459	No
3398	1978	989.0	0.0	0.0	The fluorometric measurement of deoxyribonucleic acid in animal tissues with special reference to the central nervous system.	J M Kissane, E Robins	J Biol Chem	1958	13563465	Yes
3399	989	989.0	27.82	27.8	TNF-mediated inflammatory disease.	J R Bradley	J Pathol	2008	18161752	No
3400	989	989.0	22.7	22.7	Membrane recognition by phospholipid-binding domains.	Mark A Lemmon	Nat Rev Mol Cell Biol	2008	18216767	No
3401	989	989.0	49.99	50.0	Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'.	Konrad M Andrassy	Kidney Int	2013	23989362	Yes
3402	1977	988.5	75.73	37.9	Understanding face recognition.	V Bruce, A Young	Br J Psychol	1986	3756376	Yes
3403	1976	988.0	0.0	0.0	Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats.	M J Mulvany, W Halpern	Circ Res	1977	862138	Yes
3404	988	988.0	15.86	15.9	Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast.	L Guarente	Methods Enzymol	1983	6310321	Yes
3405	988	988.0	25.82	25.8	Comparative physiology of salt and water stress.	R. Munns	Plant Cell Environ	2002	11841667	Yes
3406	988	988.0	0.0	0.0	Neural basis of the spontaneous optokinetic response produced by visual inversion.	R W Sperry	J Comp Physiol Psychol	1950	14794830	Yes
3407	988	988.0	24.88	24.9	Nitric oxide, oxidants, and protein tyrosine nitration.	Rafael Radi	Proc Natl Acad Sci U S A	2004	15020765	Yes
3408	1976	988.0	68.62	34.3	Inflammatory mechanisms in obesity.	Margaret F Gregor, Gökhan S Hotamisligil	Annu Rev Immunol	2011	21219177	No
3409	2963	987.7	97.19	32.4	A simplified ultrasensitive silver stain for detecting proteins in polyacrylamide gels.	B R Oakley, D R Kirsch, N R Morris	Anal Biochem	1980	6161559	Yes
3410	1975	987.5	39.31	19.7	CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production.	A M Thornton, E M Shevach	J Exp Med	1998	9670041	Yes
3411	1974	987.0	59.39	29.7	Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis.	C N Hales, D J Barker	Diabetologia	1992	1644236	No
3412	987	987.0	31.38	31.4	Topography of cognition: parallel distributed networks in primate association cortex.	P S Goldman-Rakic	Annu Rev Neurosci	1988	3284439	No
3413	987	987.0	29.93	29.9	Viability thresholds and the penumbra of focal ischemia.	K A Hossmann	Ann Neurol	1994	7944288	No
3414	987	987.0	37.39	37.4	Cellular mechanisms of muscle fatigue.	R H Fitts	Physiol Rev	1994	8295935	No
3415	987	987.0	25.1	25.1	The leptin receptor.	L A Tartaglia	J Biol Chem	1997	9102398	No
3416	987	987.0	28.81	28.8	Riddle of biofilm resistance.	K Lewis	Antimicrob Agents Chemother	2001	11257008	No
3417	987	987.0	23.19	23.2	Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes.	J Denis McGarry	Diabetes	2002	11756317	No
3418	1973	986.5	0.0	0.0	Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.	S Ohkuma, B Poole	Proc Natl Acad Sci U S A	1978	28524	Yes
3419	1973	986.5	41.04	20.5	Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm.	P E Wright, H J Dyson	J Mol Biol	1999	10550212	No

_{Unicorn Papers}

Top ‱ cited papers from PUBMED

Volume 11, July 2021