Unicorn Papers - Top cited papers from PUBMED

No.	Citations	EC_cit	RCR	EC_RCR	Title	Authors	Journal	Year	PMID	Article(?)
1	167006	167006.0	0.0	0.0	Cleavage of structural proteins during the assembly of the head of bacteriophage T4.	U K Laemmli	Nature	1970	5432063	Yes
2	131320	131320.0	0.0	0.0	A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.	M M Bradford	Anal Biochem	1976	942051	Yes
3	193032	48258.0	0.0	0.0	Protein measurement with the Folin phenol reagent.	O H LOWRY, N J ROSEBROUGH, A L FARR, R J RANDALL	J Biol Chem	1951	14907713	Yes
4	89376	44688.0	2473.13	1236.6	Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.	K J Livak, T D Schmittgen	Methods	2001	11846609	Yes
5	41283	41283.0	1491.53	1491.5	A short history of SHELX.	George M Sheldrick	Acta Crystallogr A	2008	18156677	Yes
6	28078	28078.0	1139.86	1139.9	Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.	T Mosmann	J Immunol Methods	1983	6606682	Yes
7	23354	23354.0	0.0	0.0	Detection of specific sequences among DNA fragments separated by gel electrophoresis.	E M Southern	J Mol Biol	1975	1195397	Yes
8	23158	23158.0	548.09	548.1	MicroRNAs: genomics, biogenesis, mechanism, and function.	David P Bartel	Cell	2004	14744438	No
9	22730	22730.0	0.0	0.0	The assessment and analysis of handedness: the Edinburgh inventory.	R C Oldfield	Neuropsychologia	1971	5146491	Yes
10	45381	22690.5	1802.32	901.2	Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.	P Chomczynski, N Sacchi	Anal Biochem	1987	2440339	Yes
11	20240	20240.0	521.27	521.3	MUSCLE: multiple sequence alignment with high accuracy and high throughput.	Robert C Edgar	Nucleic Acids Res	2004	15034147	Yes
12	20219	20219.0	510.57	510.6	A new mathematical model for relative quantification in real-time RT-PCR.	M W Pfaffl	Nucleic Acids Res	2001	11328886	Yes
13	18147	18147.0	0.0	0.0	A rating scale for depression.	M HAMILTON	J Neurol Neurosurg Psychiatry	1960	14399272	Yes
14	49679	16559.7	0.0	0.0	"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician.	M F Folstein, S E Folstein, P R McHugh	J Psychiatr Res	1975	1202204	Yes
15	32250	16125.0	1181.94	591.0	The neighbor-joining method: a new method for reconstructing phylogenetic trees.	N Saitou, M Nei	Mol Biol Evol	1987	3447015	Yes
16	15933	15933.0	655.6	655.6	Density-functional exchange-energy approximation with correct asymptotic behavior.	Becke	Phys Rev A Gen Phys	1988	9900728	Yes
17	45445	15148.3	0.0	0.0	DNA sequencing with chain-terminating inhibitors.	F Sanger, S Nicklen, A R Coulson	Proc Natl Acad Sci U S A	1977	271968	Yes
18	30284	15142.0	1129.16	564.6	Hallmarks of cancer: the next generation.	Douglas Hanahan, Robert A Weinberg	Cell	2011	21376230	No
19	14796	14796.0	542.8	542.8	CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP.	Joseph Felsenstein	Evolution	1985	28561359	Yes
20	14382	14382.0	0.0	0.0	The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.	E S REYNOLDS	J Cell Biol	1963	13986422	Yes
21	14021	14021.0	0.0	0.0	Tissue sulfhydryl groups.	G L ELLMAN	Arch Biochem Biophys	1959	13650640	Yes
22	13947	13947.0	407.62	407.6	Atherosclerosis--an inflammatory disease.	R Ross	N Engl J Med	1999	9887164	No
23	27546	13773.0	1625.48	812.7	Statistical methods for assessing agreement between two methods of clinical measurement.	J M Bland, D G Altman	Lancet	1986	2868172	Yes
24	13549	13549.0	593.54	593.5	A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences.	M Kimura	J Mol Evol	1980	7463489	Yes
25	25828	12914.0	0.0	0.0	The measurement of observer agreement for categorical data.	J R Landis, G G Koch	Biometrics	1977	843571	Yes
26	38651	12883.7	1277.42	425.8	CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.	J D Thompson, D G Higgins, T J Gibson	Nucleic Acids Res	1994	7984417	Yes
27	12641	12641.0	355.72	355.7	MicroRNAs: target recognition and regulatory functions.	David P Bartel	Cell	2009	19167326	No
28	11971	11971.0	367.58	367.6	Projector augmented-wave method.	Blöchl	Phys Rev B Condens Matter	1994	9976227	Yes
29	35746	11915.3	0.0	0.0	Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.	H Towbin, T Staehelin, J Gordon	Proc Natl Acad Sci U S A	1979	388439	Yes
30	11673	11673.0	0.0	0.0	High resolution two-dimensional electrophoresis of proteins.	P H O'Farrell	J Biol Chem	1975	236308	Yes
31	23266	11633.0	0.0	0.0	A rapid method of total lipid extraction and purification.	E G BLIGH, W J DYER	Can J Biochem Physiol	1959	13671378	Yes
32	23064	11532.0	1033.35	516.7	Meta-analysis in clinical trials.	R DerSimonian, N Laird	Control Clin Trials	1986	3802833	Yes
33	22245	11122.5	1105.2	552.6	The hospital anxiety and depression scale.	A S Zigmond, R P Snaith	Acta Psychiatr Scand	1983	6880820	Yes
34	11076	11076.0	569.42	569.4	A power primer.	J Cohen	Psychol Bull	1992	19565683	Yes
35	10621	10621.0	0.0	0.0	DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.	B J DAVIS	Ann N Y Acad Sci	1964	14240539	Yes
36	10535	10535.0	501.34	501.3	Catalase in vitro.	H Aebi	Methods Enzymol	1984	6727660	Yes
37	10472	10472.0	583.44	583.4	RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies.	Alexandros Stamatakis	Bioinformatics	2014	24451623	Yes
38	30969	10323.0	1027.63	342.5	Generalized Gradient Approximation Made Simple.	Perdew, Burke, Ernzerhof	Phys Rev Lett	1996	10062328	Yes
39	20123	10061.5	459.76	229.9	Coot: model-building tools for molecular graphics.	Paul Emsley, Kevin Cowtan	Acta Crystallogr D Biol Crystallogr	2004	15572765	Yes
40	10004	10004.0	0.0	0.0	A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.	K BURTON	Biochem J	1956	13293190	Yes
41	29876	9958.7	0.0	0.0	A simple method for the isolation and purification of total lipides from animal tissues.	J FOLCH, M LEES, G H SLOANE STANLEY	J Biol Chem	1957	13428781	Yes
42	28946	9648.7	1229.51	409.8	Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density.	Lee, Yang, Parr	Phys Rev B Condens Matter	1988	9944570	Yes
43	19282	9641.0	460.47	230.2	[20] Processing of X-ray diffraction data collected in oscillation mode.	Zbyszek Otwinowski, Wladek Minor	Methods Enzymol	1997	27799103	Yes
44	48099	9619.8	1594.9	319.0	Basic local alignment search tool.	S F Altschul, W Gish, W Miller, E W Myers, D J Lipman	J Mol Biol	1990	2231712	Yes
45	19236	9618.0	540.82	270.4	Fast and accurate short read alignment with Burrows-Wheeler transform.	Heng Li, Richard Durbin	Bioinformatics	2009	19451168	Yes
46	9615	9615.0	401.87	401.9	Structure validation in chemical crystallography.	Anthony L Spek	Acta Crystallogr D Biol Crystallogr	2009	19171970	Yes
47	19061	9530.5	1012.17	506.1	The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection.	J E Ware, C D Sherbourne	Med Care	1992	1593914	Yes
48	9287	9287.0	352.94	352.9	Search and clustering orders of magnitude faster than BLAST.	Robert C Edgar	Bioinformatics	2010	20709691	Yes
49	9103	9103.0	0.0	0.0	The genetics of Caenorhabditis elegans.	S Brenner	Genetics	1974	4366476	Yes
50	9088	9088.0	273.83	273.8	XDS.	Wolfgang Kabsch	Acta Crystallogr D Biol Crystallogr	2010	20124692	Yes
51	17301	8650.5	656.12	328.1	Fast gapped-read alignment with Bowtie 2.	Ben Langmead, Steven L Salzberg	Nat Methods	2012	22388286	Yes
52	8636	8636.0	352.61	352.6	Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS).	J F Kurtzke	Neurology	1983	6685237	Yes
53	8597	8597.0	285.5	285.5	The Psychophysics Toolbox.	D H Brainard	Spat Vis	1997	9176952	Yes
54	8424	8424.0	0.0	0.0	Phosphorus assay in column chromatography.	G R BARTLETT	J Biol Chem	1959	13641241	Yes
55	8135	8135.0	185.78	185.8	Mfold web server for nucleic acid folding and hybridization prediction.	Michael Zuker	Nucleic Acids Res	2003	12824337	Yes
56	8019	8019.0	370.34	370.3	A new method for measuring daytime sleepiness: the Epworth sleepiness scale.	M W Johns	Sleep	1991	1798888	Yes
57	7995	7995.0	228.45	228.4	RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models.	Alexandros Stamatakis	Bioinformatics	2006	16928733	Yes
58	7985	7985.0	173.18	173.2	Linear models and empirical bayes methods for assessing differential expression in microarray experiments.	Gordon K Smyth	Stat Appl Genet Mol Biol	2004	16646809	Yes
59	7960	7960.0	584.76	584.8	Crystal structure refinement with SHELXL.	George M Sheldrick	Acta Crystallogr C Struct Chem	2015	25567568	Yes
60	15886	7943.0	504.46	252.2	Quantifying heterogeneity in a meta-analysis.	Julian P T Higgins, Simon G Thompson	Stat Med	2002	12111919	Yes
61	15839	7919.5	366.62	183.3	The hallmarks of cancer.	D Hanahan, R A Weinberg	Cell	2000	10647931	No
62	15724	7862.0	574.46	287.2	A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.	A P Feinberg, B Vogelstein	Anal Biochem	1983	6312838	Yes
63	7799	7799.0	266.77	266.8	Studies on transformation of Escherichia coli with plasmids.	D Hanahan	J Mol Biol	1983	6345791	Yes
64	15469	7734.5	461.44	230.7	Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set.	Kresse, Furthmüller	Phys Rev B Condens Matter	1996	9984901	Yes
65	7731	7731.0	0.0	0.0	Self-efficacy: toward a unifying theory of behavioral change.	A Bandura	Psychol Rev	1977	847061	Yes
66	7682	7682.0	258.37	258.4	Evolutionary trees from DNA sequences: a maximum likelihood approach.	J Felsenstein	J Mol Evol	1981	7288891	Yes
67	15015	7507.5	796.7	398.4	The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations.	R M Baron, D A Kenny	J Pers Soc Psychol	1986	3806354	Yes
68	7458	7458.0	253.39	253.4	Vitamin D deficiency.	Michael F Holick	N Engl J Med	2007	17634462	No
69	14890	7445.0	501.21	250.6	A simple method for displaying the hydropathic character of a protein.	J Kyte, R F Doolittle	J Mol Biol	1982	7108955	Yes
70	21991	7330.3	620.25	206.8	VMD: visual molecular dynamics.	W Humphrey, A Dalke, K Schulten	J Mol Graph	1996	8744570	Yes
71	7249	7249.0	259.14	259.1	The pathogenesis of atherosclerosis: a perspective for the 1990s.	R Ross	Nature	1993	8479518	No
72	7235	7235.0	162.81	162.8	The functions of animal microRNAs.	Victor Ambros	Nature	2004	15372042	No
73	28844	7211.0	974.74	243.7	Measuring inconsistency in meta-analyses.	Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman	BMJ	2003	12958120	No
74	7191	7191.0	0.0	0.0	On the origin of cancer cells.	O WARBURG	Science	1956	13298683	Yes
75	7063	7063.0	216.56	216.6	Semiempirical GGA-type density functional constructed with a long-range dispersion correction.	Stefan Grimme	J Comput Chem	2006	16955487	Yes
76	7019	7019.0	291.85	291.9	Banting lecture 1988. Role of insulin resistance in human disease.	G M Reaven	Diabetes	1988	3056758	No
77	6969	6969.0	0.0	0.0	Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.	A Böyum	Scand J Clin Lab Invest Suppl	1968	4179068	Yes
78	13864	6932.0	330.68	165.3	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.	Kazutoshi Takahashi, Shinya Yamanaka	Cell	2006	16904174	Yes
79	6905	6905.0	0.0	0.0	Improvements in epoxy resin embedding methods.	J H LUFT	J Biophys Biochem Cytol	1961	13764136	Yes
80	20437	6812.3	590.54	196.8	Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.	Da Wei Huang, Brad T Sherman, Richard A Lempicki	Nat Protoc	2009	19131956	Yes
81	6777	6777.0	219.48	219.5	Integrins: versatility, modulation, and signaling in cell adhesion.	R O Hynes	Cell	1992	1555235	No
82	6664	6664.0	0.0	0.0	COPPER ENZYMES IN ISOLATED CHLOROPLASTS. POLYPHENOLOXIDASE IN BETA VULGARIS.	D I Arnon	Plant Physiol	1949	16654194	Yes
83	6649	6649.0	370.67	370.7	Psychophysical bases of perceived exertion.	G A Borg	Med Sci Sports Exerc	1982	7154893	Yes
84	26566	6641.5	1175.72	293.9	A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.	M E Charlson, P Pompei, K L Ales, C R MacKenzie	J Chronic Dis	1987	3558716	Yes
85	6633	6633.0	196.55	196.6	Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.	M C Hochberg	Arthritis Rheum	1997	9324032	Yes
86	13222	6611.0	356.7	178.3	MrBayes 3: Bayesian phylogenetic inference under mixed models.	Fredrik Ronquist, John P Huelsenbeck	Bioinformatics	2003	12912839	Yes
87	13199	6599.5	299.75	149.9	Processing of X-ray diffraction data collected in oscillation mode.	Z Otwinowski, W Minor	Methods Enzymol	1997	27754618	Yes
88	6450	6450.0	210.89	210.9	AFNI: software for analysis and visualization of functional magnetic resonance neuroimages.	R W Cox	Comput Biomed Res	1996	8812068	Yes
89	12888	6444.0	0.0	0.0	The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.	K Weber, M Osborn	J Biol Chem	1969	5806584	Yes
90	25609	6402.2	1185.75	296.4	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	PLoS Med	2009	19621072	No
91	12726	6363.0	376.64	188.3	Analyzing real-time PCR data by the comparative C(T) method.	Thomas D Schmittgen, Kenneth J Livak	Nat Protoc	2008	18546601	Yes
92	44347	6335.3	1274.31	182.0	Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.	S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J Lipman	Nucleic Acids Res	1997	9254694	No
93	6326	6326.0	201.33	201.3	Canonical dynamics: Equilibrium phase-space distributions.	Hoover	Phys Rev A Gen Phys	1985	9895674	Yes
94	18960	6320.0	777.68	259.2	NIH Image to ImageJ: 25 years of image analysis.	Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri	Nat Methods	2012	22930834	No
95	6318	6318.0	146.96	147.0	Chromatin modifications and their function.	Tony Kouzarides	Cell	2007	17320507	No
96	6315	6315.0	167.6	167.6	PAML 4: phylogenetic analysis by maximum likelihood.	Ziheng Yang	Mol Biol Evol	2007	17483113	Yes
97	25144	6286.0	946.14	236.5	Bias in meta-analysis detected by a simple, graphical test.	M Egger, G Davey Smith, M Schneider, C Minder	BMJ	1997	9310563	Yes
98	6245	6245.0	221.07	221.1	The blockade of immune checkpoints in cancer immunotherapy.	Drew M Pardoll	Nat Rev Cancer	2012	22437870	No
99	6244	6244.0	196.26	196.3	TreeView: an application to display phylogenetic trees on personal computers.	R D Page	Comput Appl Biosci	1996	8902363	Yes
100	12469	6234.5	291.38	145.7	Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana.	S J Clough, A F Bent	Plant J	1998	10069079	Yes
101	6205	6205.0	185.48	185.5	Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.	F Tajima	Genetics	1989	2513255	Yes
102	6173	6173.0	259.75	259.8	Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses.	Andreas Stang	Eur J Epidemiol	2010	20652370	Yes
103	6149	6149.0	246.01	246.0	Density-functional approximation for the correlation energy of the inhomogeneous electron gas.	Perdew	Phys Rev B Condens Matter	1986	9938299	Yes
104	6030	6030.0	168.41	168.4	Fast robust automated brain extraction.	Stephen M Smith	Hum Brain Mapp	2002	12391568	No
105	17523	5841.0	812.15	270.7	Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.	Michael I Love, Wolfgang Huber, Simon Anders	Genome Biol	2014	25516281	Yes
106	5839	5839.0	235.57	235.6	Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.	P S Thomas	Proc Natl Acad Sci U S A	1980	6159641	Yes
107	5812	5812.0	222.07	222.1	"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.	W N Burnette	Anal Biochem	1981	6266278	Yes
108	5790	5790.0	0.0	0.0	A simplification of the protein assay method of Lowry et al. which is more generally applicable.	G L Peterson	Anal Biochem	1977	603028	Yes
109	11327	5663.5	253.94	127.0	KEGG: kyoto encyclopedia of genes and genomes.	M Kanehisa, S Goto	Nucleic Acids Res	2000	10592173	Yes
110	5661	5661.0	167.32	167.3	Apoptosis: a review of programmed cell death.	Susan Elmore	Toxicol Pathol	2007	17562483	No
111	5636	5636.0	228.12	228.1	Ethical guidelines for investigations of experimental pain in conscious animals.	Manfred Zimmermann	Pain	1983	6877845	No
112	5629	5629.0	188.31	188.3	The VideoToolbox software for visual psychophysics: transforming numbers into movies.	D G Pelli	Spat Vis	1997	9176953	Yes
113	5589	5589.0	0.0	0.0	Solvent content of protein crystals.	B W Matthews	J Mol Biol	1968	5700707	Yes
114	5562	5562.0	329.92	329.9	Comparative fit indexes in structural models.	P M Bentler	Psychol Bull	1990	2320703	Yes
115	11082	5541.0	535.08	267.5	MAFFT multiple sequence alignment software version 7: improvements in performance and usability.	Kazutaka Katoh, Daron M Standley	Mol Biol Evol	2013	23329690	Yes
116	10843	5421.5	404.42	202.2	Sequencing end-labeled DNA with base-specific chemical cleavages.	A M Maxam, W Gilbert	Methods Enzymol	1980	6246368	Yes
117	5396	5396.0	116.97	117.0	Integrins: bidirectional, allosteric signaling machines.	Richard O Hynes	Cell	2002	12297042	No
118	16072	5357.3	814.23	271.4	Trimmomatic: a flexible trimmer for Illumina sequence data.	Anthony M Bolger, Marc Lohse, Bjoern Usadel	Bioinformatics	2014	24695404	Yes
119	5356	5356.0	0.0	0.0	A low-viscosity epoxy resin embedding medium for electron microscopy.	A R Spurr	J Ultrastruct Res	1969	4887011	Yes
120	5327	5327.0	0.0	0.0	Tumor angiogenesis: therapeutic implications.	J Folkman	N Engl J Med	1971	4938153	No
121	15977	5325.7	1358.1	452.7	MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets.	Sudhir Kumar, Glen Stecher, Koichiro Tamura	Mol Biol Evol	2016	27004904	Yes
122	5266	5266.0	0.0	0.0	Evaluation of survival data and two new rank order statistics arising in its consideration.	N Mantel	Cancer Chemother Rep	1966	5910392	Yes
123	5249	5249.0	269.47	269.5	Investigation of the freely available easy-to-use software 'EZR' for medical statistics.	Y Kanda	Bone Marrow Transplant	2013	23208313	Yes
124	15720	5240.0	0.0	0.0	Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.	W T Friedewald, R I Levy, D S Fredrickson	Clin Chem	1972	4337382	Yes
125	5192	5192.0	196.74	196.7	The Clinical Dementia Rating (CDR): current version and scoring rules.	J C Morris	Neurology	1993	8232972	Yes
126	5174	5174.0	138.35	138.3	Inflammation, atherosclerosis, and coronary artery disease.	Göran K Hansson	N Engl J Med	2005	15843671	No
127	5168	5168.0	128.01	128.0	Inflammation in atherosclerosis.	Peter Libby	Nature	2002	12490960	No
128	5159	5159.0	201.47	201.5	The role of protein kinase C in cell surface signal transduction and tumour promotion.	Y Nishizuka	Nature	1984	6232463	No
129	15447	5149.0	566.11	188.7	A new generation of Ca2+ indicators with greatly improved fluorescence properties.	G Grynkiewicz, M Poenie, R Y Tsien	J Biol Chem	1985	3838314	Yes
130	5076	5076.0	152.21	152.2	Angiogenesis in cancer, vascular, rheumatoid and other disease.	J Folkman	Nat Med	1995	7584949	No
131	5076	5076.0	100.37	100.4	BLAT--the BLAST-like alignment tool.	W James Kent	Genome Res	2002	11932250	Yes
132	5037	5037.0	135.78	135.8	Biochemistry and molecular cell biology of diabetic complications.	M Brownlee	Nature	2001	11742414	Yes
133	5000	5000.0	119.32	119.3	p53, the cellular gatekeeper for growth and division.	A J Levine	Cell	1997	9039259	No
134	9995	4997.5	0.0	0.0	A rapid alkaline extraction procedure for screening recombinant plasmid DNA.	H C Birnboim, J Doly	Nucleic Acids Res	1979	388356	Yes
135	9968	4984.0	269.27	134.6	MRBAYES: Bayesian inference of phylogenetic trees.	J P Huelsenbeck, F Ronquist	Bioinformatics	2001	11524383	Yes
136	4983	4983.0	0.0	0.0	The assessment of anxiety states by rating.	M HAMILTON	Br J Med Psychol	1959	13638508	Yes
137	4968	4968.0	0.0	0.0	Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.	J R Vane	Nat New Biol	1971	5284360	Yes
138	4955	4955.0	133.01	133.0	Free radicals in the physiological control of cell function.	Wulf Dröge	Physiol Rev	2002	11773609	No
139	9848	4924.0	253.34	126.7	A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood.	Stéphane Guindon, Olivier Gascuel	Syst Biol	2003	14530136	Yes
140	4917	4917.0	0.0	0.0	Development of a rating scale for primary depressive illness.	M Hamilton	Br J Soc Clin Psychol	1967	6080235	Yes
141	9697	4848.5	0.0	0.0	Intraclass correlations: uses in assessing rater reliability.	P E Shrout, J L Fleiss	Psychol Bull	1979	18839484	No
142	9688	4844.0	0.0	0.0	Continuous cultures of fused cells secreting antibody of predefined specificity.	G Köhler, C Milstein	Nature	1975	1172191	Yes
143	14513	4837.7	530.01	176.7	Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.	Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien	Ann Surg	2004	15273542	Yes
144	9664	4832.0	236.7	118.3	Dendritic cells and the control of immunity.	J Banchereau, R M Steinman	Nature	1998	9521319	No
145	9659	4829.5	233.91	117.0	One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.	K A Datsenko, B L Wanner	Proc Natl Acad Sci U S A	2000	10829079	Yes
146	9650	4825.0	414.88	207.4	The meaning and use of the area under a receiver operating characteristic (ROC) curve.	J A Hanley, B J McNeil	Radiology	1982	7063747	Yes
147	9648	4824.0	0.0	0.0	Prediction of creatinine clearance from serum creatinine.	D W Cockcroft, M H Gault	Nephron	1976	1244564	Yes
148	4822	4822.0	0.0	0.0	Modification of seizure activity by electrical stimulation. II. Motor seizure.	R J Racine	Electroencephalogr Clin Neurophysiol	1972	4110397	Yes
149	4798	4798.0	200.22	200.2	The Strengths and Difficulties Questionnaire: a research note.	R Goodman	J Child Psychol Psychiatry	1997	9255702	Yes
150	9586	4793.0	304.87	152.4	MODELTEST: testing the model of DNA substitution.	D Posada, K A Crandall	Bioinformatics	1998	9918953	Yes
151	9577	4788.5	0.0	0.0	Statistical aspects of the analysis of data from retrospective studies of disease.	N MANTEL, W HAENSZEL	J Natl Cancer Inst	1959	13655060	Yes
152	4772	4772.0	124.47	124.5	Antimicrobial peptides of multicellular organisms.	Michael Zasloff	Nature	2002	11807545	Yes
153	4749	4749.0	173.22	173.2	jModelTest: phylogenetic model averaging.	David Posada	Mol Biol Evol	2008	18397919	Yes
154	4742	4742.0	116.88	116.9	Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis.	J Castresana	Mol Biol Evol	2000	10742046	Yes
155	23624	4724.8	725.2	145.0	The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.	J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G Higgins	Nucleic Acids Res	1997	9396791	Yes
156	4714	4714.0	136.23	136.2	Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm.	T A Springer	Cell	1994	7507411	No
157	9410	4705.0	0.0	0.0	Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.	Y Cheng, W H Prusoff	Biochem Pharmacol	1973	4202581	Yes
158	4693	4693.0	125.75	125.8	Inflammation and metabolic disorders.	Gökhan S Hotamisligil	Nature	2006	17167474	No
159	4683	4683.0	251.81	251.8	UPARSE: highly accurate OTU sequences from microbial amplicon reads.	Robert C Edgar	Nat Methods	2013	23955772	Yes
160	4681	4681.0	163.03	163.0	The steroid and thyroid hormone receptor superfamily.	R M Evans	Science	1988	3283939	No
161	4658	4658.0	145.32	145.3	Inositol trisphosphate and calcium signalling.	M J Berridge	Nature	1993	8381210	No
162	13909	4636.3	417.32	139.1	edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.	Mark D Robinson, Davis J McCarthy, Gordon K Smyth	Bioinformatics	2010	19910308	Yes
163	13794	4598.0	0.0	0.0	Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.	H Ohkawa, N Ohishi, K Yagi	Anal Biochem	1979	36810	Yes
164	4571	4571.0	113.04	113.0	The biochemistry of apoptosis.	M O Hengartner	Nature	2000	11048727	No
165	9060	4530.0	260.49	130.2	Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features.	W Kabsch, C Sander	Biopolymers	1983	6667333	Yes
166	4512	4512.0	94.77	94.8	Epithelial-mesenchymal transitions in tumour progression.	Jean Paul Thiery	Nat Rev Cancer	2002	12189386	No
167	8996	4498.0	367.1	183.6	Three approaches to qualitative content analysis.	Hsiu-Fang Hsieh, Sarah E Shannon	Qual Health Res	2005	16204405	Yes
168	4446	4446.0	265.01	265.0	Prokka: rapid prokaryotic genome annotation.	Torsten Seemann	Bioinformatics	2014	24642063	Yes
169	4445	4445.0	123.71	123.7	The NF-kappa B and I kappa B proteins: new discoveries and insights.	A S Baldwin	Annu Rev Immunol	1996	8717528	No
170	4403	4403.0	118.92	118.9	Rapid and efficient site-specific mutagenesis without phenotypic selection.	T A Kunkel	Proc Natl Acad Sci U S A	1985	3881765	Yes
171	4403	4403.0	136.4	136.4	A modified poisson regression approach to prospective studies with binary data.	Guangyong Zou	Am J Epidemiol	2004	15033648	Yes
172	4399	4399.0	95.94	95.9	Rho GTPases and the actin cytoskeleton.	A Hall	Science	1998	9438836	No
173	13174	4391.3	468.49	156.2	The PHQ-9: validity of a brief depression severity measure.	K Kroenke, R L Spitzer, J B Williams	J Gen Intern Med	2001	11556941	Yes
174	17547	4386.8	588.46	147.1	MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0.	Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir Kumar	Mol Biol Evol	2007	17488738	Yes
175	4372	4372.0	147.89	147.9	Adhesion receptors of the immune system.	T A Springer	Nature	1990	1974032	No
176	4365	4365.0	0.0	0.0	Aging: a theory based on free radical and radiation chemistry.	D HARMAN	J Gerontol	1956	13332224	Yes
177	4354	4354.0	129.76	129.8	Apoptosis in the pathogenesis and treatment of disease.	C B Thompson	Science	1995	7878464	No
178	4342	4342.0	156.26	156.3	Developments of a water-maze procedure for studying spatial learning in the rat.	R Morris	J Neurosci Methods	1984	6471907	Yes
179	8674	4337.0	232.39	116.2	Comparative protein modelling by satisfaction of spatial restraints.	A Sali, T L Blundell	J Mol Biol	1993	8254673	Yes
180	4332	4332.0	0.0	0.0	Selective extraction of polyoma DNA from infected mouse cell cultures.	B Hirt	J Mol Biol	1967	4291934	Yes
181	4332	4332.0	119.66	119.7	Emotion circuits in the brain.	J E LeDoux	Annu Rev Neurosci	2000	10845062	No
182	4327	4327.0	0.0	0.0	THE ENVIRONMENT AND DISEASE: ASSOCIATION OR CAUSATION?	A B HILL	Proc R Soc Med	1965	14283879	Yes
183	8649	4324.5	213.46	106.7	Primer3 on the WWW for general users and for biologist programmers.	S Rozen, H Skaletsky	Methods Mol Biol	2000	10547847	Yes
184	12832	4277.3	479.16	159.7	A simple salting out procedure for extracting DNA from human nucleated cells.	S A Miller, D D Dykes, H F Polesky	Nucleic Acids Res	1988	3344216	Yes
185	4250	4250.0	0.0	0.0	The thiobarbituric acid assay of sialic acids.	L WARREN	J Biol Chem	1959	13672998	Yes
186	4243	4243.0	299.62	299.6	SHELXT - integrated space-group and crystal-structure determination.	George M Sheldrick	Acta Crystallogr A Found Adv	2015	25537383	Yes
187	4242	4242.0	0.0	0.0	Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues.	F Tietze	Anal Biochem	1969	4388022	Yes
188	8484	4242.0	265.03	132.5	EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis.	Arnaud Delorme, Scott Makeig	J Neurosci Methods	2004	15102499	Yes
189	4240	4240.0	134.02	134.0	A fast diffeomorphic image registration algorithm.	John Ashburner	Neuroimage	2007	17761438	Yes
190	21086	4217.2	1169.02	233.8	MEGA6: Molecular Evolutionary Genetics Analysis version 6.0.	Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir Kumar	Mol Biol Evol	2013	24132122	Yes
191	12648	4216.0	341.14	113.7	Inference of population structure using multilocus genotype data.	J K Pritchard, M Stephens, P Donnelly	Genetics	2000	10835412	Yes
192	8417	4208.5	222.83	111.4	BEDTools: a flexible suite of utilities for comparing genomic features.	Aaron R Quinlan, Ira M Hall	Bioinformatics	2010	20110278	Yes
193	16809	4202.2	0.0	0.0	Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.	J M Chirgwin, A E Przybyla, R J MacDonald, W J Rutter	Biochemistry	1979	518835	Yes
194	4182	4182.0	0.0	0.0	A SELF-RATING DEPRESSION SCALE.	W W ZUNG	Arch Gen Psychiatry	1965	14221692	Yes
195	4172	4172.0	195.41	195.4	Orienting of attention.	M I Posner	Q J Exp Psychol	1980	7367577	Yes
196	25007	4167.8	3379.89	563.3	Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.	Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal	CA Cancer J Clin	2018	30207593	Yes
197	8325	4162.5	260.09	130.0	Neuropathological stageing of Alzheimer-related changes.	H Braak, E Braak	Acta Neuropathol	1991	1759558	No
198	8320	4160.0	305.21	152.6	AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading.	Oleg Trott, Arthur J Olson	J Comput Chem	2010	19499576	Yes
199	4152	4152.0	99.59	99.6	MUSCLE: a multiple sequence alignment method with reduced time and space complexity.	Robert C Edgar	BMC Bioinformatics	2004	15318951	Yes
200	8284	4142.0	194.45	97.2	Inflammation and cancer.	Lisa M Coussens, Zena Werb	Nature	2002	12490959	No
201	4124	4124.0	131.68	131.7	G proteins: transducers of receptor-generated signals.	A G Gilman	Annu Rev Biochem	1987	3113327	No
202	8193	4096.5	283.46	141.7	Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa.	H Schägger, G von Jagow	Anal Biochem	1987	2449095	Yes
203	8114	4057.0	195.7	97.8	The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.	John Hardy, Dennis J Selkoe	Science	2002	12130773	No
204	4047	4047.0	89.84	89.8	Targeting HIF-1 for cancer therapy.	Gregg L Semenza	Nat Rev Cancer	2003	13130303	No
205	12132	4044.0	439.26	146.4	Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors.	C Yanisch-Perron, J Vieira, J Messing	Gene	1985	2985470	Yes
206	8082	4041.0	233.95	117.0	Differential expression analysis for sequence count data.	Simon Anders, Wolfgang Huber	Genome Biol	2010	20979621	Yes
207	4023	4023.0	79.74	79.7	DNA methylation patterns and epigenetic memory.	Adrian Bird	Genes Dev	2002	11782440	No
208	4022	4022.0	122.94	122.9	The Cambridge Structural Database: a quarter of a million crystal structures and rising.	Frank H Allen	Acta Crystallogr B	2002	12037359	Yes
209	7989	3994.5	308.42	154.2	Operating characteristics of a rank correlation test for publication bias.	C B Begg, M Mazumdar	Biometrics	1994	7786990	Yes
210	11917	3972.3	280.94	93.6	Refinement of macromolecular structures by the maximum-likelihood method.	G N Murshudov, A A Vagin, E J Dodson	Acta Crystallogr D Biol Crystallogr	1997	15299926	Yes
211	23814	3969.0	1065.95	177.7	MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods.	Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir Kumar	Mol Biol Evol	2011	21546353	Yes
212	23776	3962.7	1010.71	168.5	Global cancer statistics.	Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David Forman	CA Cancer J Clin	2011	21296855	Yes
213	7922	3961.0	0.0	0.0	A series of normal stages in the development of the chick embryo.	V HAMBURGER, H L HAMILTON	J Morphol	1951	24539719	Yes
214	3951	3951.0	140.99	141.0	New M13 vectors for cloning.	J Messing	Methods Enzymol	1983	6310323	Yes
215	7902	3951.0	238.67	119.3	The rise of graphene.	A K Geim, K S Novoselov	Nat Mater	2007	17330084	Yes
216	7899	3949.5	0.0	0.0	A quantitative description of membrane current and its application to conduction and excitation in nerve.	A L HODGKIN, A F HUXLEY	J Physiol	1952	12991237	Yes
217	11828	3942.7	526.57	175.5	The positive and negative syndrome scale (PANSS) for schizophrenia.	S R Kay, A Fiszbein, L A Opler	Schizophr Bull	1987	3616518	Yes
218	3926	3926.0	74.12	74.1	Generalized lacZ expression with the ROSA26 Cre reporter strain.	P Soriano	Nat Genet	1999	9916792	Yes
219	3855	3855.0	0.0	0.0	Index for rating diagnostic tests.	W J YOUDEN	Cancer	1950	15405679	Yes
220	3819	3819.0	101.47	101.5	An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.	M Kozak	Nucleic Acids Res	1987	3313277	No
221	3819	3819.0	86.21	86.2	Alternative activation of macrophages.	Siamon Gordon	Nat Rev Immunol	2003	12511873	No
222	3818	3818.0	92.47	92.5	Prions.	S B Prusiner	Proc Natl Acad Sci U S A	1998	9811807	No
223	3809	3809.0	116.52	116.5	Mild cognitive impairment as a diagnostic entity.	R C Petersen	J Intern Med	2004	15324362	No
224	7599	3799.5	0.0	0.0	FUNCTIONAL EVALUATION: THE BARTHEL INDEX.	F I MAHONEY, D W BARTHEL	Md State Med J	1965	14258950	Yes
225	3798	3798.0	93.18	93.2	Alzheimer's disease: genes, proteins, and therapy.	D J Selkoe	Physiol Rev	2001	11274343	No
226	7577	3788.5	0.0	0.0	A new depression scale designed to be sensitive to change.	S A Montgomery, M Asberg	Br J Psychiatry	1979	444788	Yes
227	7574	3787.0	0.0	0.0	Assessment of older people: self-maintaining and instrumental activities of daily living.	M P Lawton, E M Brody	Gerontologist	1969	5349366	Yes
228	3777	3777.0	0.0	0.0	Mutation and cancer: statistical study of retinoblastoma.	A G Knudson	Proc Natl Acad Sci U S A	1971	5279523	Yes
229	3756	3756.0	118.66	118.7	How mitochondria produce reactive oxygen species.	Michael P Murphy	Biochem J	2009	19061483	No
230	3743	3743.0	186.12	186.1	Revisiting the behavioral model and access to medical care: does it matter?	R M Andersen	J Health Soc Behav	1995	7738325	Yes
231	3733	3733.0	160.86	160.9	An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies.	Peter C Austin	Multivariate Behav Res	2011	21818162	Yes
232	3731	3731.0	0.0	0.0	Preparation of isolated rat liver cells.	P O Seglen	Methods Cell Biol	1976	177845	No
233	3729	3729.0	0.0	0.0	Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents.	M M Mesulam	J Histochem Cytochem	1978	24068	Yes
234	7442	3721.0	232.8	116.4	A synaptic model of memory: long-term potentiation in the hippocampus.	T V Bliss, G L Collingridge	Nature	1993	8421494	No
235	7419	3709.5	191.31	95.7	SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling.	N Guex, M C Peitsch	Electrophoresis	1997	9504803	Yes
236	3706	3706.0	82.19	82.2	Wnt/beta-catenin signaling in development and disease.	Hans Clevers	Cell	2006	17081971	No
237	11110	3703.3	841.52	280.5	Cancer statistics, 2016.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2016	26742998	Yes
238	3690	3690.0	0.0	0.0	The McGill Pain Questionnaire: major properties and scoring methods.	Ronald Melzack	Pain	1975	1235985	Yes
239	7332	3666.0	343.6	171.8	The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.	R F Furchgott, J V Zawadzki	Nature	1980	6253831	Yes
240	7326	3663.0	0.0	0.0	THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.	T OMURA, R SATO	J Biol Chem	1964	14209971	Yes
241	3653	3653.0	88.96	89.0	Cancer cell cycles.	C J Sherr	Science	1996	8939849	No
242	3647	3647.0	75.55	75.5	The phosphoinositide 3-kinase pathway.	Lewis C Cantley	Science	2002	12040186	No
243	10931	3643.7	381.03	127.0	A comprehensive set of sequence analysis programs for the VAX.	J Devereux, P Haeberli, O Smithies	Nucleic Acids Res	1984	6546423	Yes
244	3639	3639.0	0.0	0.0	The genetical evolution of social behaviour. I.	W D Hamilton	J Theor Biol	1964	5875341	Yes
245	14529	3632.2	551.98	138.0	G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences.	Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner	Behav Res Methods	2007	17695343	Yes
246	18104	3620.8	0.0	0.0	An inventory for measuring depression.	A T BECK, C H WARD, M MENDELSON, J MOCK, J ERBAUGH	Arch Gen Psychiatry	1961	13688369	Yes
247	3620	3620.0	0.0	0.0	THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION.	P LAUREN	Acta Pathol Microbiol Scand	1965	14320675	Yes
248	3614	3614.0	178.71	178.7	Oxygen-derived free radicals in postischemic tissue injury.	J M McCord	N Engl J Med	1985	2981404	No
249	7186	3593.0	181.85	90.9	Collective dynamics of 'small-world' networks.	D J Watts, S H Strogatz	Nature	1998	9623998	Yes
250	7129	3564.5	171.32	85.7	MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification.	Jürgen Cox, Matthias Mann	Nat Biotechnol	2008	19029910	Yes
251	7113	3556.5	0.0	0.0	A new technique for the assay of infectivity of human adenovirus 5 DNA.	F L Graham, A J van der Eb	Virology	1973	4705382	Yes
252	3555	3555.0	0.0	0.0	The detection of disease clustering and a generalized regression approach.	N Mantel	Cancer Res	1967	6018555	Yes
253	7086	3543.0	230.55	115.3	Improved tools for biological sequence comparison.	W R Pearson, D J Lipman	Proc Natl Acad Sci U S A	1988	3162770	Yes
254	3520	3520.0	93.83	93.8	Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.	M Kozak	Cell	1986	3943125	Yes
255	3520	3520.0	83.3	83.3	PAML: a program package for phylogenetic analysis by maximum likelihood.	Z Yang	Comput Appl Biosci	1997	9367129	Yes
256	3504	3504.0	0.0	0.0	The clonal evolution of tumor cell populations.	P C Nowell	Science	1976	959840	Yes
257	3496	3496.0	125.74	125.7	Updating P300: an integrative theory of P3a and P3b.	John Polich	Clin Neurophysiol	2007	17573239	No
258	6974	3487.0	210.42	105.2	Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy.	Florian Weigend, Reinhart Ahlrichs	Phys Chem Chem Phys	2005	16240044	Yes
259	3486	3486.0	81.57	81.6	Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.	C J Marshall	Cell	1995	7834738	No
260	3473	3473.0	141.17	141.2	Studies and perspectives of protein kinase C.	Y Nishizuka	Science	1986	3014651	No
261	10417	3472.3	540.66	180.2	Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.	S M Hsu, L Raine, H Fanger	J Histochem Cytochem	1981	6166661	Yes
262	6931	3465.5	193.94	97.0	A genetic model for colorectal tumorigenesis.	E R Fearon, B Vogelstein	Cell	1990	2188735	No
263	3458	3458.0	82.16	82.2	Tandem repeats finder: a program to analyze DNA sequences.	G Benson	Nucleic Acids Res	1999	9862982	Yes
264	3443	3443.0	90.19	90.2	Mechanisms of angiogenesis.	W Risau	Nature	1997	9109485	No
265	10312	3437.3	921.73	307.2	Cancer Statistics, 2017.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2017	28055103	Yes
266	6859	3429.5	251.16	125.6	DnaSP v5: a software for comprehensive analysis of DNA polymorphism data.	P Librado, J Rozas	Bioinformatics	2009	19346325	Yes
267	3423	3423.0	114.89	114.9	A new method for predicting signal sequence cleavage sites.	G von Heijne	Nucleic Acids Res	1986	3714490	Yes
268	13682	3420.5	415.96	104.0	Features and development of Coot.	P Emsley, B Lohkamp, W G Scott, K Cowtan	Acta Crystallogr D Biol Crystallogr	2010	20383002	Yes
269	3409	3409.0	0.0	0.0	Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation.	W H Harris	J Bone Joint Surg Am	1969	5783851	Yes
270	3409	3409.0	144.98	145.0	Whatever happened to qualitative description?	M Sandelowski	Res Nurs Health	2000	10940958	No
271	6814	3407.0	218.64	109.3	RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome.	Bo Li, Colin N Dewey	BMC Bioinformatics	2011	21816040	Yes
272	10220	3406.7	460.87	153.6	Nitric oxide: physiology, pathophysiology, and pharmacology.	S Moncada, R M Palmer, E A Higgs	Pharmacol Rev	1991	1852778	No
273	3404	3404.0	151.59	151.6	EuroQol: the current state of play.	R Brooks	Health Policy	1996	10158943	No
274	13579	3394.8	0.0	0.0	A new and rapid colorimetric determination of acetylcholinesterase activity.	G L ELLMAN, K D COURTNEY, V ANDRES, R M FEATHER-STONE	Biochem Pharmacol	1961	13726518	Yes
275	6786	3393.0	151.32	75.7	A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.	R S Sikorski, P Hieter	Genetics	1989	2659436	Yes
276	3391	3391.0	98.56	98.6	Staphylococcus aureus infections.	F D Lowy	N Engl J Med	1998	9709046	No
277	3382	3382.0	0.0	0.0	THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS.	L HAYFLICK	Exp Cell Res	1965	14315085	Yes
278	3375	3375.0	98.97	99.0	Sequencing technologies - the next generation.	Michael L Metzker	Nat Rev Genet	2010	19997069	No
279	3366	3366.0	0.0	0.0	Estimation of nuclear population from microtome sections.	M ABERCROMBIE	Anat Rec	1946	21015608	Yes
280	3365	3365.0	90.96	91.0	ras oncogenes in human cancer: a review.	J L Bos	Cancer Res	1989	2547513	No
281	3363	3363.0	75.33	75.3	The green fluorescent protein.	R Y Tsien	Annu Rev Biochem	1998	9759496	No
282	3359	3359.0	81.1	81.1	Atherosclerosis.	A J Lusis	Nature	2000	11001066	No
283	3344	3344.0	79.48	79.5	Protein production by auto-induction in high density shaking cultures.	F William Studier	Protein Expr Purif	2005	15915565	Yes
284	20056	3342.7	799.91	133.3	Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.	D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C Turner	Diabetologia	1985	3899825	Yes
285	6678	3339.0	0.0	0.0	Parkinsonism: onset, progression and mortality.	M M Hoehn, M D Yahr	Neurology	1967	6067254	Yes
286	6671	3335.5	0.0	0.0	Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).	J M McCord, I Fridovich	J Biol Chem	1969	5389100	Yes
287	6671	3335.5	132.98	66.5	Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.	A H Brand, N Perrimon	Development	1993	8223268	Yes
288	3320	3320.0	84.12	84.1	Apoptosis by death factor.	S Nagata	Cell	1997	9039262	No
289	3313	3313.0	138.63	138.6	ANALYZING TABLES OF STATISTICAL TESTS.	William R Rice	Evolution	1989	28568501	Yes
290	3305	3305.0	73.49	73.5	Protein secondary structure prediction based on position-specific scoring matrices.	D T Jones	J Mol Biol	1999	10493868	Yes
291	6606	3303.0	178.55	89.3	tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence.	T M Lowe, S R Eddy	Nucleic Acids Res	1997	9023104	Yes
292	6605	3302.5	0.0	0.0	A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.	W M Bonner, R A Laskey	Eur J Biochem	1974	4850204	Yes
293	3301	3301.0	85.4	85.4	Why most published research findings are false.	John P A Ioannidis	PLoS Med	2005	16060722	Yes
294	6587	3293.5	283.88	141.9	Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness.	U H Graneheim, B Lundman	Nurse Educ Today	2004	14769454	No
295	3283	3283.0	96.16	96.2	Multiple sequence alignment with hierarchical clustering.	F Corpet	Nucleic Acids Res	1988	2849754	Yes
296	6541	3270.5	207.78	103.9	BEAST: Bayesian evolutionary analysis by sampling trees.	Alexei J Drummond, Andrew Rambaut	BMC Evol Biol	2007	17996036	Yes
297	6540	3270.0	0.0	0.0	Assessment of coma and impaired consciousness. A practical scale.	G Teasdale, B Jennett	Lancet	1974	4136544	Yes
298	13063	3265.8	391.08	97.8	Global cancer statistics, 2002.	D Max Parkin, Freddie Bray, J Ferlay, Paola Pisani	CA Cancer J Clin	2005	15761078	Yes
299	3262	3262.0	0.0	0.0	The need for a new medical model: a challenge for biomedicine.	G L Engel	Science	1977	847460	Yes
300	3259	3259.0	123.95	124.0	Glutamate neurotoxicity and diseases of the nervous system.	D W Choi	Neuron	1988	2908446	No
301	3244	3244.0	74.22	74.2	The retinoblastoma protein and cell cycle control.	R A Weinberg	Cell	1995	7736585	No
302	3234	3234.0	102.02	102.0	Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing.	S Henikoff	Gene	1984	6235151	Yes
303	3229	3229.0	0.0	0.0	Bone: formation by autoinduction.	M R Urist	Science	1965	5319761	Yes
304	9682	3227.3	1184.24	394.7	Cancer statistics, 2018.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2018	29313949	Yes
305	3226	3226.0	126.06	126.1	Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.	P Matsudaira	J Biol Chem	1987	3611052	Yes
306	6449	3224.5	196.92	98.5	Ab initio molecular dynamics for liquid metals.	Kresse, Hafner	Phys Rev B Condens Matter	1993	10004490	Yes
307	3219	3219.0	76.42	76.4	Scaling and assessment of data quality.	Philip Evans	Acta Crystallogr D Biol Crystallogr	2006	16369096	No
308	6436	3218.0	278.92	139.5	Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models.	Kristopher J Preacher, Andrew F Hayes	Behav Res Methods	2008	18697684	Yes
309	6434	3217.0	341.01	170.5	Ligand: a versatile computerized approach for characterization of ligand-binding systems.	P J Munson, D Rodbard	Anal Biochem	1980	6254391	Yes
310	3210	3210.0	105.9	105.9	Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C.	Y Nishizuka	Science	1992	1411571	No
311	3208	3208.0	150.26	150.3	The pathogenesis of atherosclerosis--an update.	R Ross	N Engl J Med	1986	3511384	No
312	3191	3191.0	72.34	72.3	TGF-beta signal transduction.	J Massagué	Annu Rev Biochem	1998	9759503	No
313	3190	3190.0	98.32	98.3	Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group.	R B D'Agostino	Stat Med	1998	9802183	Yes
314	3184	3184.0	77.46	77.5	Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.	Rakesh K Jain	Science	2005	15637262	No
315	9536	3178.7	440.35	146.8	A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity.	J Ware, M Kosinski, S D Keller	Med Care	1996	8628042	Yes
316	3173	3173.0	82.92	82.9	Nonalcoholic fatty liver disease.	Paul Angulo	N Engl J Med	2002	11961152	No
317	6331	3165.5	182.28	91.1	Control of goal-directed and stimulus-driven attention in the brain.	Maurizio Corbetta, Gordon L Shulman	Nat Rev Neurosci	2002	11994752	No
318	3162	3162.0	113.71	113.7	genepop'007: a complete re-implementation of the genepop software for Windows and Linux.	François Rousset	Mol Ecol Resour	2008	21585727	Yes
319	3160	3160.0	0.0	0.0	Evolution in Mendelian Populations.	S Wright	Genetics	1931	17246615	Yes
320	3158	3158.0	67.85	67.8	Hypoxia--a key regulatory factor in tumour growth.	Adrian L Harris	Nat Rev Cancer	2002	11902584	No
321	3156	3156.0	104.85	104.8	Soft self-consistent pseudopotentials in a generalized eigenvalue formalism.	Vanderbilt	Phys Rev B Condens Matter	1990	9993096	Yes
322	3154	3154.0	101.8	101.8	Revisions in the International System for Staging Lung Cancer.	C F Mountain	Chest	1997	9187198	Yes
323	3146	3146.0	90.18	90.2	The dendritic cell system and its role in immunogenicity.	R M Steinman	Annu Rev Immunol	1991	1910679	No
324	9435	3145.0	463.22	154.4	Cancer statistics, 2013.	Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal	CA Cancer J Clin	2013	23335087	Yes
325	6287	3143.5	153.55	76.8	Functional rafts in cell membranes.	K Simons, E Ikonen	Nature	1997	9177342	No
326	3129	3129.0	114.99	115.0	How do you feel--now? The anterior insula and human awareness.	A D Bud Craig	Nat Rev Neurosci	2009	19096369	No
327	3128	3128.0	82.04	82.0	Marrow stromal cells as stem cells for nonhematopoietic tissues.	D J Prockop	Science	1997	9082988	No
328	3105	3105.0	138.13	138.1	Measuring the accuracy of diagnostic systems.	J A Swets	Science	1988	3287615	No
329	6197	3098.5	0.0	0.0	Radiological assessment of osteo-arthrosis.	J H KELLGREN, J S LAWRENCE	Ann Rheum Dis	1957	13498604	Yes
330	9247	3082.3	482.74	160.9	Development and validation of brief measures of positive and negative affect: the PANAS scales.	D Watson, L A Clark, A Tellegen	J Pers Soc Psychol	1988	3397865	Yes
331	6163	3081.5	171.55	85.8	Mitochondria and apoptosis.	D R Green, J C Reed	Science	1998	9721092	No
332	3078	3078.0	83.34	83.3	Cancer. p53, guardian of the genome.	D P Lane	Nature	1992	1614522	No
333	3077	3077.0	0.0	0.0	A rapid banding technique for human chromosomes.	M Seabright	Lancet	1971	4107917	Yes
334	3075	3075.0	0.0	0.0	Principles that govern the folding of protein chains.	C B Anfinsen	Science	1973	4124164	Yes
335	3072	3072.0	71.29	71.3	Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.	G R Martin	Proc Natl Acad Sci U S A	1981	6950406	Yes
336	9213	3071.0	230.05	76.7	Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.	J D Dignam, R M Lebovitz, R G Roeder	Nucleic Acids Res	1983	6828386	Yes
337	3067	3067.0	66.5	66.5	Mammalian neural stem cells.	F H Gage	Science	2000	10688783	No
338	6130	3065.0	0.0	0.0	Microsomal lipid peroxidation.	J A Buege, S D Aust	Methods Enzymol	1978	672633	Yes
339	3060	3060.0	92.23	92.2	The adolescent brain and age-related behavioral manifestations.	L P Spear	Neurosci Biobehav Rev	2000	10817843	No
340	3052	3052.0	0.0	0.0	A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients.	E Pfeiffer	J Am Geriatr Soc	1975	1159263	Yes
341	3049	3049.0	83.62	83.6	Caspases: the executioners of apoptosis.	G M Cohen	Biochem J	1997	9337844	No
342	9111	3037.0	575.77	191.9	Cancer statistics, 2015.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2015	25559415	Yes
343	12139	3034.8	316.18	79.0	Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.	Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg	Genome Biol	2009	19261174	Yes
344	6057	3028.5	304.75	152.4	The timed "Up & Go": a test of basic functional mobility for frail elderly persons.	D Podsiadlo, S Richardson	J Am Geriatr Soc	1991	1991946	Yes
345	6057	3028.5	187.06	93.5	Velvet: algorithms for de novo short read assembly using de Bruijn graphs.	Daniel R Zerbino, Ewan Birney	Genome Res	2008	18349386	Yes
346	3026	3026.0	87.98	88.0	Microglia: a sensor for pathological events in the CNS.	G W Kreutzberg	Trends Neurosci	1996	8843599	No
347	3017	3017.0	0.0	0.0	Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.	C B Laurell	Anal Biochem	1966	5959431	Yes
348	3016	3016.0	83.3	83.3	I-TASSER server for protein 3D structure prediction.	Yang Zhang	BMC Bioinformatics	2008	18215316	Yes
349	3012	3012.0	85.67	85.7	Oxidative stress, antioxidants and stress tolerance.	Ron Mittler	Trends Plant Sci	2002	12234732	No
350	3011	3011.0	102.7	102.7	What's wrong with Bonferroni adjustments.	T V Perneger	BMJ	1998	9553006	No
351	18066	3011.0	1172.74	195.5	Global cancer statistics, 2012.	Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin Jemal	CA Cancer J Clin	2015	25651787	Yes
352	12043	3010.8	542.66	135.7	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	Ann Intern Med	2009	19622511	No
353	3008	3008.0	0.0	0.0	A membrane-filter technique for the detection of complementary DNA.	D T Denhardt	Biochem Biophys Res Commun	1966	5963888	Yes
354	3008	3008.0	115.19	115.2	Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence.	Ilan H Meyer	Psychol Bull	2003	12956539	No
355	3006	3006.0	62.28	62.3	Signal transduction by the JNK group of MAP kinases.	R J Davis	Cell	2000	11057897	No
356	2998	2998.0	97.3	97.3	Graphene: status and prospects.	A K Geim	Science	2009	19541989	Yes
357	2996	2996.0	73.44	73.4	Instability and decay of the primary structure of DNA.	T Lindahl	Nature	1993	8469282	No
358	8958	2986.0	0.0	0.0	Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.	W H Habig, M J Pabst, W B Jakoby	J Biol Chem	1974	4436300	Yes
359	5970	2985.0	113.29	56.6	Translating the histone code.	T Jenuwein, C D Allis	Science	2001	11498575	No
360	2984	2984.0	65.36	65.4	Profile hidden Markov models.	S R Eddy	Bioinformatics	1998	9918945	No
361	2983	2983.0	0.0	0.0	Determination of protein: a modification of the Lowry method that gives a linear photometric response.	E F Hartree	Anal Biochem	1972	4115981	Yes
362	2981	2981.0	115.87	115.9	Bacterial evolution.	C R Woese	Microbiol Rev	1987	2439888	No
363	2980	2980.0	137.58	137.6	A concordance correlation coefficient to evaluate reproducibility.	L I Lin	Biometrics	1989	2720055	Yes
364	2978	2978.0	82.58	82.6	Novel proteinaceous infectious particles cause scrapie.	S B Prusiner	Science	1982	6801762	Yes
365	2974	2974.0	0.0	0.0	The Scree Test For The Number Of Factors.	R B Cattell	Multivariate Behav Res	1966	26828106	Yes
366	5947	2973.5	166.4	83.2	An integrative theory of prefrontal cortex function.	E K Miller, J D Cohen	Annu Rev Neurosci	2001	11283309	No
367	2969	2969.0	0.0	0.0	METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS.	M RODBELL	J Biol Chem	1964	14169133	Yes
368	2965	2965.0	77.61	77.6	Glutamate uptake.	N C Danbolt	Prog Neurobiol	2001	11369436	No
369	2962	2962.0	83.89	83.9	The origins and the future of microfluidics.	George M Whitesides	Nature	2006	16871203	No
370	2961	2961.0	85.68	85.7	Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?	Kim A Brogden	Nat Rev Microbiol	2005	15703760	No
371	2960	2960.0	115.24	115.2	Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD.	Russell A Barkley	Psychol Bull	1997	9000892	No
372	2959	2959.0	102.77	102.8	Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation.	A H Wyllie	Nature	1980	6245367	Yes
373	2958	2958.0	104.37	104.4	The molecular heterogeneity of protein kinase C and its implications for cellular regulation.	Y Nishizuka	Nature	1988	3045562	No
374	2945	2945.0	102.02	102.0	Protective and damaging effects of stress mediators.	B S McEwen	N Engl J Med	1998	9428819	No
375	5888	2944.0	170.7	85.3	Genomic sequencing.	G M Church, W Gilbert	Proc Natl Acad Sci U S A	1984	6326095	Yes
376	8804	2934.7	330.49	110.2	Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.	E R DeLong, D M DeLong, D L Clarke-Pearson	Biometrics	1988	3203132	Yes
377	5858	2929.0	270.75	135.4	The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay.	I F Benzie, J J Strain	Anal Biochem	1996	8660627	Yes
378	5844	2922.0	124.27	62.1	Statistical significance for genomewide studies.	John D Storey, Robert Tibshirani	Proc Natl Acad Sci U S A	2003	12883005	Yes
379	2919	2919.0	97.91	97.9	What is the evidence that tumors are angiogenesis dependent?	J Folkman	J Natl Cancer Inst	1990	1688381	No
380	2916	2916.0	0.0	0.0	Transformed up-down methods in psychoacoustics.	H Levitt	J Acoust Soc Am	1971	5541744	Yes
381	2912	2912.0	0.0	0.0	New methods for calculating metabolic rate with special reference to protein metabolism.	J B DE B WEIR	J Physiol	1949	15394301	Yes
382	2909	2909.0	110.67	110.7	Modeling valuations for EuroQol health states.	P Dolan	Med Care	1997	9366889	Yes
383	2906	2906.0	70.14	70.1	Folding DNA to create nanoscale shapes and patterns.	Paul W K Rothemund	Nature	2006	16541064	Yes
384	5806	2903.0	0.0	0.0	Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.	D E Paglia, W N Valentine	J Lab Clin Med	1967	6066618	Yes
385	2903	2903.0	0.0	0.0	Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit.	J Cohen	Psychol Bull	1968	19673146	Yes
386	5779	2889.5	233.89	116.9	Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows.	Laurent Excoffier, Heidi E L Lischer	Mol Ecol Resour	2010	21565059	Yes
387	5769	2884.5	2181.03	1090.5	Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention.	Zunyou Wu, Jennifer M McGoogan	JAMA	2020	32091533	Yes
388	8612	2870.7	1663.51	554.5	Cancer statistics, 2019.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2019	30620402	Yes
389	5737	2868.5	164.81	82.4	The basics of epithelial-mesenchymal transition.	Raghu Kalluri, Robert A Weinberg	J Clin Invest	2009	19487818	No
390	2868	2868.0	0.0	0.0	Amino acid metabolism in mammalian cell cultures.	H EAGLE	Science	1959	13675766	Yes
391	2863	2863.0	0.0	0.0	Estimation of average heterozygosity and genetic distance from a small number of individuals.	M Nei	Genetics	1978	17248844	Yes
392	2862	2862.0	80.22	80.2	ras genes.	M Barbacid	Annu Rev Biochem	1987	3304147	No
393	8584	2861.3	386.65	128.9	Cancer statistics, 2012.	Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal	CA Cancer J Clin	2012	22237781	Yes
394	5709	2854.5	142.38	71.2	WGCNA: an R package for weighted correlation network analysis.	Peter Langfelder, Steve Horvath	BMC Bioinformatics	2008	19114008	Yes
395	5706	2853.0	185.88	92.9	ESTIMATING F-STATISTICS FOR THE ANALYSIS OF POPULATION STRUCTURE.	B S Weir, C Clark Cockerham	Evolution	1984	28563791	Yes
396	8558	2852.7	0.0	0.0	Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.	J F Kerr, A H Wyllie, A R Currie	Br J Cancer	1972	4561027	No
397	5698	2849.0	142.89	71.4	Inference of macromolecular assemblies from crystalline state.	Evgeny Krissinel, Kim Henrick	J Mol Biol	2007	17681537	Yes
398	2837	2837.0	81.5	81.5	Free R value: a novel statistical quantity for assessing the accuracy of crystal structures.	A T Brünger	Nature	1992	18481394	Yes
399	2835	2835.0	96.09	96.1	Biological roles of oligosaccharides: all of the theories are correct.	A Varki	Glycobiology	1993	8490246	No
400	2826	2826.0	78.48	78.5	The basis of anisotropic water diffusion in the nervous system - a technical review.	Christian Beaulieu	NMR Biomed	2002	12489094	No
401	2825	2825.0	119.13	119.1	Tissue destruction by neutrophils.	S J Weiss	N Engl J Med	1989	2536474	No
402	8475	2825.0	418.58	139.5	A global measure of perceived stress.	S Cohen, T Kamarck, R Mermelstein	J Health Soc Behav	1983	6668417	Yes
403	2819	2819.0	103.07	103.1	Development of a classification system for periodontal diseases and conditions.	G C Armitage	Ann Periodontol	1999	10863370	No
404	2817	2817.0	0.0	0.0	Generalized expectancies for internal versus external control of reinforcement.	J B Rotter	Psychol Monogr	1966	5340840	No
405	2815	2815.0	95.73	95.7	Functions of DNA methylation: islands, start sites, gene bodies and beyond.	Peter A Jones	Nat Rev Genet	2012	22641018	No
406	2805	2805.0	94.04	94.0	Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis.	Thomas Welton	Chem Rev	1999	11849019	Yes
407	5608	2804.0	112.58	56.3	The ubiquitin system.	A Hershko, A Ciechanover	Annu Rev Biochem	1998	9759494	No
408	2802	2802.0	82.53	82.5	A catalogue of splice junction sequences.	S M Mount	Nucleic Acids Res	1982	7063411	Yes
409	19573	2796.1	471.48	67.4	UCSF Chimera--a visualization system for exploratory research and analysis.	Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin	J Comput Chem	2004	15264254	Yes
410	2792	2792.0	0.0	0.0	Observational study of behavior: sampling methods.	J Altmann	Behaviour	1974	4597405	No
411	2786	2786.0	0.0	0.0	The determination of enzyme inhibitor constants.	M DIXON	Biochem J	1953	13093635	Yes
412	2768	2768.0	0.0	0.0	Aggregation of blood platelets by adenosine diphosphate and its reversal.	G V BORN	Nature	1962	13871375	Yes
413	2767	2767.0	98.43	98.4	Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans.	L R Squire	Psychol Rev	1992	1594723	No
414	2756	2756.0	65.23	65.2	Activators and target genes of Rel/NF-kappaB transcription factors.	H L Pahl	Oncogene	1999	10602461	No
415	13774	2754.8	512.83	102.6	Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.	O P Hamill, A Marty, E Neher, B Sakmann, F J Sigworth	Pflugers Arch	1981	6270629	Yes
416	2752	2752.0	77.84	77.8	How do you feel? Interoception: the sense of the physiological condition of the body.	A D Craig	Nat Rev Neurosci	2002	12154366	No
417	8245	2748.3	176.14	58.7	Significance analysis of microarrays applied to the ionizing radiation response.	V G Tusher, R Tibshirani, G Chu	Proc Natl Acad Sci U S A	2001	11309499	Yes
418	5494	2747.0	142.53	71.3	The plant immune system.	Jonathan D G Jones, Jeffery L Dangl	Nature	2006	17108957	No
419	2726	2726.0	95.0	95.0	Integrins: a family of cell surface receptors.	R O Hynes	Cell	1987	3028640	No
420	8177	2725.7	182.76	60.9	Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.	Benjamin P Lewis, Christopher B Burge, David P Bartel	Cell	2005	15652477	Yes
421	2725	2725.0	54.89	54.9	Cell signaling by receptor tyrosine kinases.	J Schlessinger	Cell	2000	11057895	No
422	2721	2721.0	72.5	72.5	Wound healing--aiming for perfect skin regeneration.	P Martin	Science	1997	9082989	No
423	2719	2719.0	112.62	112.6	Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity.	J H Morrissey	Anal Biochem	1981	6172996	Yes
424	8153	2717.7	220.31	73.4	Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists.	Da Wei Huang, Brad T Sherman, Richard A Lempicki	Nucleic Acids Res	2009	19033363	Yes
425	2716	2716.0	77.49	77.5	Neural networks and physical systems with emergent collective computational abilities.	J J Hopfield	Proc Natl Acad Sci U S A	1982	6953413	Yes
426	5429	2714.5	223.65	111.8	Management of hepatocellular carcinoma: an update.	Jordi Bruix, Morris Sherman	Hepatology	2011	21374666	No
427	2713	2713.0	0.0	0.0	Basic principles of ROC analysis.	C E Metz	Semin Nucl Med	1978	112681	Yes
428	2712	2712.0	77.01	77.0	The pathobiology of diabetic complications: a unifying mechanism.	Michael Brownlee	Diabetes	2005	15919781	No
429	2709	2709.0	70.24	70.2	Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies.	Ting-Chao Chou	Pharmacol Rev	2006	16968952	No
430	2707	2707.0	59.47	59.5	STATs and gene regulation.	J E Darnell	Science	1997	9287210	No
431	2705	2705.0	103.64	103.6	Emerging adulthood. A theory of development from the late teens through the twenties.	J J Arnett	Am Psychol	2000	10842426	Yes
432	2702	2702.0	0.0	0.0	Staining of tissue sections for electron microscopy with heavy metals.	M L WATSON	J Biophys Biochem Cytol	1958	13563554	Yes
433	2695	2695.0	161.3	161.3	Executive functions.	Adele Diamond	Annu Rev Psychol	2013	23020641	No
434	2688	2688.0	69.12	69.1	Photoelectrochemical cells.	M Grätzel	Nature	2001	11713540	Yes
435	2686	2686.0	85.78	85.8	EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis.	W Klimesch	Brain Res Brain Res Rev	1999	10209231	No
436	5364	2682.0	124.81	62.4	Toll-like receptor signalling.	Shizuo Akira, Kiyoshi Takeda	Nat Rev Immunol	2004	15229469	No
437	2681	2681.0	57.23	57.2	The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited.	Isaiah J Fidler	Nat Rev Cancer	2003	12778135	No
438	10670	2667.5	283.4	70.8	Haploview: analysis and visualization of LD and haplotype maps.	J C Barrett, B Fry, J Maller, M J Daly	Bioinformatics	2005	15297300	Yes
439	2666	2666.0	61.44	61.4	Protein folding and misfolding.	Christopher M Dobson	Nature	2003	14685248	No
440	5320	2660.0	128.49	64.2	MicroRNA signatures in human cancers.	George A Calin, Carlo M Croce	Nat Rev Cancer	2006	17060945	No
441	2657	2657.0	61.46	61.5	Somatic generation of antibody diversity.	S Tonegawa	Nature	1983	6300689	No
442	5284	2642.0	125.48	62.7	Angiogenesis in cancer and other diseases.	P Carmeliet, R K Jain	Nature	2000	11001068	No
443	2640	2640.0	70.16	70.2	The scanning model for translation: an update.	M Kozak	J Cell Biol	1989	2645293	No
444	2640	2640.0	0.0	0.0	The colorimetric estimation of formaldehyde by means of the Hantzsch reaction.	T NASH	Biochem J	1953	13105648	Yes
445	5275	2637.5	0.0	0.0	Preparation of iodine-131 labelled human growth hormone of high specific activity.	W M HUNTER, F C GREENWOOD	Nature	1962	14450081	Yes
446	2631	2631.0	132.91	132.9	Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine.	O W Griffith	Anal Biochem	1980	7416462	Yes
447	2626	2626.0	82.12	82.1	Hay fever, hygiene, and household size.	D P Strachan	BMJ	1989	2513902	Yes
448	2626	2626.0	80.79	80.8	Drug combination studies and their synergy quantification using the Chou-Talalay method.	Ting-Chao Chou	Cancer Res	2010	20068163	Yes
449	2623	2623.0	73.24	73.2	WHAT IF: a molecular modeling and drug design program.	G Vriend	J Mol Graph	1990	2268628	Yes
450	2614	2614.0	79.6	79.6	Mesenchymal stem cells.	A I Caplan	J Orthop Res	1991	1870029	Yes
451	10405	2601.2	289.15	72.3	Improved methods for building protein models in electron density maps and the location of errors in these models.	T A Jones, J Y Zou, S W Cowan, M Kjeldgaard	Acta Crystallogr A	1991	2025413	Yes
452	7799	2599.7	384.81	128.3	HTSeq--a Python framework to work with high-throughput sequencing data.	Simon Anders, Paul Theodor Pyl, Wolfgang Huber	Bioinformatics	2015	25260700	Yes
453	2589	2589.0	96.43	96.4	Health promotion by social cognitive means.	Albert Bandura	Health Educ Behav	2004	15090118	Yes
454	2589	2589.0	90.05	90.0	Hepatocellular carcinoma.	Hashem B El-Serag	N Engl J Med	2011	21992124	No
455	5174	2587.0	168.73	84.4	Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis.	S Duval, R Tweedie	Biometrics	2000	10877304	Yes
456	7757	2585.7	199.54	66.5	TopHat: discovering splice junctions with RNA-Seq.	Cole Trapnell, Lior Pachter, Steven L Salzberg	Bioinformatics	2009	19289445	Yes
457	5170	2585.0	148.52	74.3	Voxel-based morphometry--the methods.	J Ashburner, K J Friston	Neuroimage	2000	10860804	No
458	5168	2584.0	0.0	0.0	Receptive fields, binocular interaction and functional architecture in the cat's visual cortex.	D H HUBEL, T N WIESEL	J Physiol	1962	14449617	Yes
459	2579	2579.0	64.44	64.4	Tolerance, danger, and the extended family.	P Matzinger	Annu Rev Immunol	1994	8011301	No
460	2578	2578.0	66.08	66.1	Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.	H F Dvorak	N Engl J Med	1986	3537791	No
461	5148	2574.0	137.92	69.0	Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase.	C Tuerk, L Gold	Science	1990	2200121	Yes
462	5148	2574.0	95.09	47.5	The language of covalent histone modifications.	B D Strahl, C D Allis	Nature	2000	10638745	Yes
463	2574	2574.0	57.7	57.7	Alzheimer's disease is a synaptic failure.	Dennis J Selkoe	Science	2002	12399581	No
464	2572	2572.0	78.64	78.6	The heat-shock response.	S Lindquist	Annu Rev Biochem	1986	2427013	No
465	2572	2572.0	79.96	80.0	Non-coding RNAs in human disease.	Manel Esteller	Nat Rev Genet	2011	22094949	No
466	2571	2571.0	85.74	85.7	Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.	R W Mahley	Science	1988	3283935	No
467	2570	2570.0	104.19	104.2	Nitric oxide as a secretory product of mammalian cells.	C Nathan	FASEB J	1992	1381691	No
468	2570	2570.0	51.95	52.0	Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling.	P Schuck	Biophys J	2000	10692345	Yes
469	7707	2569.0	0.0	0.0	Determination of serum proteins by means of the biuret reaction.	A G GORNALL, C J BARDAWILL, M M DAVID	J Biol Chem	1949	18110453	Yes
470	2566	2566.0	60.98	61.0	Cardiac excitation-contraction coupling.	Donald M Bers	Nature	2002	11805843	No
471	2566	2566.0	0.0	0.0	[A micro-method of immuno-electrophoresis].	J J SCHEIDEGGER	Int Arch Allergy Appl Immunol	1955	13262900	Yes
472	2565	2565.0	78.51	78.5	Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection.	Y X Fu	Genetics	1997	9335623	Yes
473	2563	2563.0	60.37	60.4	Angiogenesis in health and disease.	Peter Carmeliet	Nat Med	2003	12778163	No
474	2559	2559.0	0.0	0.0	The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid.	J F WOESSNER	Arch Biochem Biophys	1961	13786180	Yes
475	2551	2551.0	73.21	73.2	Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.	M Kozak	Nucleic Acids Res	1984	6694911	Yes
476	2549	2549.0	97.59	97.6	No adjustments are needed for multiple comparisons.	K J Rothman	Epidemiology	1990	2081237	Yes
477	5090	2545.0	0.0	0.0	Human malaria parasites in continuous culture.	W Trager, J B Jensen	Science	1976	781840	Yes
478	5089	2544.5	141.67	70.8	Fast and accurate long-read alignment with Burrows-Wheeler transform.	Heng Li, Richard Durbin	Bioinformatics	2010	20080505	Yes
479	5081	2540.5	157.77	78.9	Projections of global mortality and burden of disease from 2002 to 2030.	Colin D Mathers, Dejan Loncar	PLoS Med	2006	17132052	Yes
480	10118	2529.5	445.36	111.3	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	BMJ	2009	19622551	No
481	2525	2525.0	82.67	82.7	ABC transporters: from microorganisms to man.	C F Higgins	Annu Rev Cell Biol	1992	1282354	No
482	2524	2524.0	51.03	51.0	RNA interference.	Gregory J Hannon	Nature	2002	12110901	No
483	2524	2524.0	64.35	64.3	Mitochondrial formation of reactive oxygen species.	Julio F Turrens	J Physiol	2003	14561818	No
484	2518	2518.0	68.69	68.7	Origin and physiological roles of inflammation.	Ruslan Medzhitov	Nature	2008	18650913	No
485	2515	2515.0	59.79	59.8	Mechanisms of angiogenesis and arteriogenesis.	P Carmeliet	Nat Med	2000	10742145	No
486	5017	2508.5	111.86	55.9	Emergence of scaling in random networks	Barabasi, Albert	Science	1999	10521342	Yes
487	10017	2504.2	370.73	92.7	Cancer statistics, 2010.	Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth Ward	CA Cancer J Clin	2010	20610543	Yes
488	2503	2503.0	67.4	67.4	Obesity as a medical problem.	P G Kopelman	Nature	2000	10766250	No
489	2503	2503.0	89.93	89.9	Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report.	Sarah E Barlow	Pediatrics	2007	18055651	Yes
490	5001	2500.5	119.99	60.0	Oncomirs - microRNAs with a role in cancer.	Aurora Esquela-Kerscher, Frank J Slack	Nat Rev Cancer	2006	16557279	No
491	2499	2499.0	72.95	73.0	Biologic basis for interleukin-1 in disease.	C A Dinarello	Blood	1996	8630372	No
492	7488	2496.0	210.51	70.2	Understanding the Warburg effect: the metabolic requirements of cell proliferation.	Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson	Science	2009	19460998	No
493	2487	2487.0	76.05	76.0	Optimal two-stage designs for phase II clinical trials.	R Simon	Control Clin Trials	1989	2702835	Yes
494	2483	2483.0	0.0	0.0	DISC ELECTROPHORESIS. I. BACKGROUND AND THEORY.	L ORNSTEIN	Ann N Y Acad Sci	1964	14240533	Yes
495	2480	2480.0	0.0	0.0	Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.	J D Rowley	Nature	1973	4126434	Yes
496	2480	2480.0	0.0	0.0	Spectroscopic determination of tryptophan and tyrosine in proteins.	H Edelhoch	Biochemistry	1967	6049437	Yes
497	2479	2479.0	0.0	0.0	Stereotaxic mapping of the monoamine pathways in the rat brain.	U Ungerstedt	Acta Physiol Scand Suppl	1971	4109331	Yes
498	7427	2475.7	215.03	71.7	MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment.	Sudhir Kumar, Koichiro Tamura, Masatoshi Nei	Brief Bioinform	2004	15260895	Yes
499	22263	2473.7	627.13	69.7	The Sequence Alignment/Map format and SAMtools.	Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin	Bioinformatics	2009	19505943	Yes
500	2473	2473.0	94.68	94.7	Psychometric properties of the strengths and difficulties questionnaire.	R Goodman	J Am Acad Child Adolesc Psychiatry	2001	11699809	Yes
501	2466	2466.0	53.05	53.0	Toll-like receptors and innate immunity.	R Medzhitov	Nat Rev Immunol	2001	11905821	No
502	2464	2464.0	69.38	69.4	Recent advances with liposomes as pharmaceutical carriers.	Vladimir P Torchilin	Nat Rev Drug Discov	2005	15688077	No
503	2462	2462.0	59.01	59.0	Inflammatory bowel disease.	Daniel K Podolsky	N Engl J Med	2002	12167685	No
504	14747	2457.8	621.47	103.6	Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support.	Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G Conde	J Biomed Inform	2009	18929686	Yes
505	2453	2453.0	62.61	62.6	CpG-rich islands and the function of DNA methylation.	A P Bird	Nature	1986	2423876	No
506	4904	2452.0	166.91	83.5	"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.	A P Feinberg, B Vogelstein	Anal Biochem	1984	6329026	Yes
507	2451	2451.0	0.0	0.0	Statistical estimations in enzyme kinetics.	G N WILKINSON	Biochem J	1961	13785321	Yes
508	2449	2449.0	66.59	66.6	Chemokines--chemotactic cytokines that mediate inflammation.	A D Luster	N Engl J Med	1998	9459648	No
509	4883	2441.5	0.0	0.0	Superoxide dismutase: improved assays and an assay applicable to acrylamide gels.	C Beauchamp, I Fridovich	Anal Biochem	1971	4943714	Yes
510	2441	2441.0	58.35	58.4	TGFbeta in Cancer.	Joan Massagué	Cell	2008	18662538	No
511	2437	2437.0	87.86	87.9	Estimation of metabolite concentrations from localized in vivo proton NMR spectra.	S W Provencher	Magn Reson Med	1993	8139448	Yes
512	2426	2426.0	103.49	103.5	Inositol trisphosphate and diacylglycerol as second messengers.	M J Berridge	Biochem J	1984	6146314	No
513	4845	2422.5	171.66	85.8	mTOR signaling in growth control and disease.	Mathieu Laplante, David M Sabatini	Cell	2012	22500797	No
514	4843	2421.5	198.88	99.4	Measuring agreement in method comparison studies.	J M Bland, D G Altman	Stat Methods Med Res	1999	10501650	No
515	7258	2419.3	283.31	94.4	Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases.	R A Deyo, D C Cherkin, M A Ciol	J Clin Epidemiol	1992	1607900	Yes
516	4829	2414.5	152.09	76.0	TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.	T R Mosmann, R L Coffman	Annu Rev Immunol	1989	2523712	No
517	4827	2413.5	180.86	90.4	Tissue engineering.	R Langer, J P Vacanti	Science	1993	8493529	No
518	4825	2412.5	0.0	0.0	A new method for sequencing DNA.	A M Maxam, W Gilbert	Proc Natl Acad Sci U S A	1977	265521	Yes
519	4825	2412.5	0.0	0.0	The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.	R C Graham, M J Karnovsky	J Histochem Cytochem	1966	5962951	Yes
520	2410	2410.0	47.85	47.9	Genome maintenance mechanisms for preventing cancer.	J H Hoeijmakers	Nature	2001	11357144	No
521	4819	2409.5	120.18	60.1	Oxidants, oxidative stress and the biology of ageing.	T Finkel, N J Holbrook	Nature	2000	11089981	No
522	4806	2403.0	131.03	65.5	In vitro selection of RNA molecules that bind specific ligands.	A D Ellington, J W Szostak	Nature	1990	1697402	Yes
523	2403	2403.0	95.27	95.3	Essential oils: their antibacterial properties and potential applications in foods--a review.	Sara Burt	Int J Food Microbiol	2004	15246235	No
524	2402	2402.0	108.32	108.3	Half a century of research on the Stroop effect: an integrative review.	C M MacLeod	Psychol Bull	1991	2034749	No
525	2401	2401.0	108.5	108.5	FreeSurfer.	Bruce Fischl	Neuroimage	2012	22248573	No
526	4797	2398.5	148.09	74.0	The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.	Taro Kawai, Shizuo Akira	Nat Immunol	2010	20404851	No
527	2397	2397.0	56.69	56.7	Nuclear factor-kappaB in cancer development and progression.	Michael Karin	Nature	2006	16724054	No
528	2393	2393.0	55.42	55.4	One-step gene disruption in yeast.	R J Rothstein	Methods Enzymol	1983	6310324	Yes
529	2388	2388.0	52.26	52.3	Interleukin-12 and the regulation of innate resistance and adaptive immunity.	Giorgio Trinchieri	Nat Rev Immunol	2003	12563297	No
530	2383	2383.0	42.03	42.0	Mechanisms underlying ubiquitination.	C M Pickart	Annu Rev Biochem	2001	11395416	No
531	11906	2381.2	552.09	110.4	The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research.	D J Buysse, C F Reynolds, T H Monk, S R Berman, D J Kupfer	Psychiatry Res	1989	2748771	Yes
532	2380	2380.0	124.47	124.5	Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy.	T E Moffitt	Psychol Rev	1993	8255953	No
533	2380	2380.0	0.0	0.0	The magical number seven plus or minus two: some limits on our capacity for processing information.	G A MILLER	Psychol Rev	1956	13310704	Yes
534	2379	2379.0	131.34	131.3	The short-form McGill Pain Questionnaire.	Ronald Melzack	Pain	1987	3670870	Yes
535	4758	2379.0	174.6	87.3	The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM.	Stephen B Edge, Carolyn C Compton	Ann Surg Oncol	2010	20180029	No
536	2374	2374.0	0.0	0.0	Perceived exertion as an indicator of somatic stress.	G Borg	Scand J Rehabil Med	1970	5523831	Yes
537	9484	2371.0	216.29	54.1	Cluster analysis and display of genome-wide expression patterns.	M B Eisen, P T Spellman, P O Brown, D Botstein	Proc Natl Acad Sci U S A	1998	9843981	Yes
538	4731	2365.5	178.85	89.4	The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers.	J Vieira, J Messing	Gene	1982	6295879	Yes
539	7096	2365.3	223.15	74.4	Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study.	G Evanno, S Regnaut, J Goudet	Mol Ecol	2005	15969739	Yes
540	2365	2365.0	50.05	50.0	Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses.	Shimon Sakaguchi	Annu Rev Immunol	2004	15032588	No
541	4723	2361.5	135.07	67.5	Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.	T C Chou, P Talalay	Adv Enzyme Regul	1984	6382953	Yes
542	9442	2360.5	357.99	89.5	A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu.	Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge Krieg	J Chem Phys	2010	20423165	Yes
543	4716	2358.0	129.38	64.7	Exploring the full spectrum of macrophage activation.	David M Mosser, Justin P Edwards	Nat Rev Immunol	2008	19029990	No
544	2350	2350.0	63.6	63.6	The resurgence of platinum-based cancer chemotherapy.	Lloyd Kelland	Nat Rev Cancer	2007	17625587	No
545	2348	2348.0	51.72	51.7	Papillomaviruses and cancer: from basic studies to clinical application.	Harald zur Hausen	Nat Rev Cancer	2002	12044010	No
546	2345	2345.0	67.74	67.7	Predictive reward signal of dopamine neurons.	W Schultz	J Neurophysiol	1998	9658025	No
547	7020	2340.0	168.33	56.1	The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.	R C Lee, R L Feinbaum, V Ambros	Cell	1993	8252621	Yes
548	4677	2338.5	175.64	87.8	Computed tomography--an increasing source of radiation exposure.	David J Brenner, Eric J Hall	N Engl J Med	2007	18046031	No
549	2338	2338.0	0.0	0.0	Estimation of the molecular weights of proteins by Sephadex gel-filtration.	P Andrews	Biochem J	1964	4158310	Yes
550	7010	2336.7	297.63	99.2	Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups.	Allison Tong, Peter Sainsbury, Jonathan Craig	Int J Qual Health Care	2007	17872937	Yes
551	2335	2335.0	95.42	95.4	The processing-speed theory of adult age differences in cognition.	T A Salthouse	Psychol Rev	1996	8759042	No
552	2335	2335.0	61.15	61.1	Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays.	S A Bustin	J Mol Endocrinol	2000	11013345	No
553	2329	2329.0	0.0	0.0	Some factors in the interpretation of protein denaturation.	W KAUZMANN	Adv Protein Chem	1959	14404936	Yes
554	2325	2325.0	49.95	50.0	The danger model: a renewed sense of self.	Polly Matzinger	Science	2002	11951032	Yes
555	4647	2323.5	154.65	77.3	Complex brain networks: graph theoretical analysis of structural and functional systems.	Ed Bullmore, Olaf Sporns	Nat Rev Neurosci	2009	19190637	No
556	2321	2321.0	0.0	0.0	The glomerular permeability determined by dextran clearance using Sephadex gel filtration.	C E Mogensen	Scand J Clin Lab Invest	1968	5637478	Yes
557	2321	2321.0	75.01	75.0	Phase separation of integral membrane proteins in Triton X-114 solution.	C Bordier	J Biol Chem	1981	6257680	Yes
558	2316	2316.0	52.31	52.3	Getting started with yeast.	F Sherman	Methods Enzymol	1991	2005794	Yes
559	9261	2315.2	459.97	115.0	APACHE II: a severity of disease classification system.	W A Knaus, E A Draper, D P Wagner, J E Zimmerman	Crit Care Med	1985	3928249	Yes
560	2314	2314.0	61.01	61.0	Molecular chaperones in cellular protein folding.	F U Hartl	Nature	1996	8637592	No
561	2314	2314.0	65.09	65.1	The genetic legacy of the Quaternary ice ages.	G Hewitt	Nature	2000	10879524	No
562	4626	2313.0	0.0	0.0	Assessment of outcome after severe brain damage.	B Jennett, M Bond	Lancet	1975	46957	Yes
563	4623	2311.5	109.83	54.9	Establishment in culture of pluripotential cells from mouse embryos.	M J Evans, M H Kaufman	Nature	1981	7242681	Yes
564	4619	2309.5	120.37	60.2	Caspases: enemies within.	N A Thornberry, Y Lazebnik	Science	1998	9721091	No
565	4616	2308.0	100.55	50.3	Innate immune recognition.	Charles A Janeway, Ruslan Medzhitov	Annu Rev Immunol	2002	11861602	No
566	2303	2303.0	0.0	0.0	A gene complex controlling segmentation in Drosophila.	E B Lewis	Nature	1978	103000	Yes
567	4598	2299.0	126.35	63.2	Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.	D B Smith, K S Johnson	Gene	1988	3047011	Yes
568	2298	2298.0	0.0	0.0	Gene action in the X-chromosome of the mouse (Mus musculus L.).	M F LYON	Nature	1961	13764598	Yes
569	4584	2292.0	0.0	0.0	PERIODONTAL DISEASE IN PREGNANCY. II. CORRELATION BETWEEN ORAL HYGIENE AND PERIODONTAL CONDTION.	J SILNESS, H LOE	Acta Odontol Scand	1964	14158464	Yes
570	4581	2290.5	161.29	80.6	Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees.	K Tamura, M Nei	Mol Biol Evol	1993	8336541	Yes
571	2289	2289.0	59.4	59.4	Memory--a century of consolidation.	J L McGaugh	Science	2000	10634773	No
572	4565	2282.5	0.0	0.0	Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase.	S Marklund, G Marklund	Eur J Biochem	1974	4215654	Yes
573	2277	2277.0	63.65	63.6	Cadherin cell adhesion receptors as a morphogenetic regulator.	M Takeichi	Science	1991	2006419	No
574	2275	2275.0	56.94	56.9	Cell adhesion: the molecular basis of tissue architecture and morphogenesis.	B M Gumbiner	Cell	1996	8608588	No
575	4547	2273.5	0.0	0.0	A simplified method of evaluating dose-effect experiments.	J T LITCHFIELD, F WILCOXON	J Pharmacol Exp Ther	1949	18152921	Yes
576	2273	2273.0	0.0	0.0	Analysis of gene diversity in subdivided populations.	M Nei	Proc Natl Acad Sci U S A	1973	4519626	Yes
577	2269	2269.0	0.0	0.0	On the number of segregating sites in genetical models without recombination.	G A Watterson	Theor Popul Biol	1975	1145509	Yes
578	6802	2267.3	172.84	57.6	Pathogen recognition and innate immunity.	Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi	Cell	2006	16497588	No
579	4528	2264.0	0.0	0.0	Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.	H Aviv, P Leder	Proc Natl Acad Sci U S A	1972	4504350	Yes
580	4527	2263.5	134.91	67.5	Unified segmentation.	John Ashburner, Karl J Friston	Neuroimage	2005	15955494	Yes
581	2261	2261.0	54.05	54.0	Salt and drought stress signal transduction in plants.	Jian-Kang Zhu	Annu Rev Plant Biol	2002	12221975	No
582	2260	2260.0	70.78	70.8	RELION: implementation of a Bayesian approach to cryo-EM structure determination.	Sjors H W Scheres	J Struct Biol	2012	23000701	Yes
583	2259	2259.0	0.0	0.0	Models for the specific adhesion of cells to cells.	G I Bell	Science	1978	347575	No
584	6761	2253.7	234.45	78.1	Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.	Y Gavrieli, Y Sherman, S A Ben-Sasson	J Cell Biol	1992	1400587	Yes
585	2249	2249.0	43.78	43.8	Wnt signaling and cancer.	P Polakis	Genes Dev	2000	10921899	No
586	2249	2249.0	54.6	54.6	Autophagy: process and function.	Noboru Mizushima	Genes Dev	2007	18006683	No
587	2248	2248.0	65.21	65.2	Cellular and molecular mechanisms of fibrosis.	T A Wynn	J Pathol	2008	18161745	No
588	8991	2247.8	491.46	122.9	Cancer statistics, 2014.	Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin Jemal	CA Cancer J Clin	2014	24399786	Yes
589	2245	2245.0	76.52	76.5	Gene regulation by steroid hormones.	M Beato	Cell	1989	2644044	No
590	2243	2243.0	57.42	57.4	Prostaglandins and leukotrienes: advances in eicosanoid biology.	C D Funk	Science	2001	11729303	No
591	17929	2241.1	430.44	53.8	The Protein Data Bank.	H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E Bourne	Nucleic Acids Res	2000	10592235	Yes
592	4477	2238.5	0.0	0.0	Electrochemical photolysis of water at a semiconductor electrode.	A Fujishima, K Honda	Nature	1972	12635268	Yes
593	4467	2233.5	236.63	118.3	GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update.	Rod Peakall, Peter E Smouse	Bioinformatics	2012	22820204	Yes
594	2228	2228.0	0.0	0.0	Separation of leukocytes from blood and bone marrow. Introduction.	A Böyum	Scand J Clin Lab Invest Suppl	1968	5707208	Yes
595	4452	2226.0	137.16	68.6	Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes.	F W Studier, B A Moffatt	J Mol Biol	1986	3537305	Yes
596	2225	2225.0	70.5	70.5	The transforming growth factor-beta family.	J Massagué	Annu Rev Cell Biol	1990	2177343	No
597	2223	2223.0	63.86	63.9	Cell death during development of the nervous system.	R W Oppenheim	Annu Rev Neurosci	1991	2031577	No
598	4445	2222.5	95.92	48.0	MicroRNAs: small RNAs with a big role in gene regulation.	Lin He, Gregory J Hannon	Nat Rev Genet	2004	15211354	No
599	8883	2220.8	0.0	0.0	Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.	P W Rigby, M Dieckmann, C Rhodes, P Berg	J Mol Biol	1977	881736	Yes
600	2220	2220.0	0.0	0.0	Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.	S W Kessler	J Immunol	1975	1102604	Yes
601	2218	2218.0	97.29	97.3	Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM.	Joseph P Weir	J Strength Cond Res	2005	15705040	No
602	4424	2212.0	144.32	72.2	Adherence to medication.	Lars Osterberg, Terrence Blaschke	N Engl J Med	2005	16079372	No
603	2211	2211.0	78.81	78.8	Primate models of movement disorders of basal ganglia origin.	M R DeLong	Trends Neurosci	1990	1695404	No
604	6631	2210.3	289.69	96.6	Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor.	R M Palmer, A G Ferrige, S Moncada	Nature	1987	3495737	Yes
605	4414	2207.0	192.92	96.5	A method of comparing the areas under receiver operating characteristic curves derived from the same cases.	J A Hanley, B J McNeil	Radiology	1983	6878708	Yes
606	2199	2199.0	0.0	0.0	EQUILIBRIUM ULTRACENTRIFUGATION OF DILUTE SOLUTIONS.	D A YPHANTIS	Biochemistry	1964	14155091	Yes
607	2198	2198.0	50.96	51.0	Principles of CDK regulation.	D O Morgan	Nature	1995	7877684	No
608	2197	2197.0	53.2	53.2	Bone resorption by osteoclasts.	S L Teitelbaum	Science	2000	10968780	No
609	4394	2197.0	113.36	56.7	Autophagy in the pathogenesis of disease.	Beth Levine, Guido Kroemer	Cell	2008	18191218	No
610	4393	2196.5	197.15	98.6	Longitudinal data analysis for discrete and continuous outcomes.	S L Zeger, K Y Liang	Biometrics	1986	3719049	Yes
611	2196	2196.0	54.27	54.3	Epigenetics in cancer.	Manel Esteller	N Engl J Med	2008	18337604	No
612	8777	2194.2	317.01	79.3	Establishing a standard definition for child overweight and obesity worldwide: international survey.	T J Cole, M C Bellizzi, K M Flegal, W H Dietz	BMJ	2000	10797032	Yes
613	2192	2192.0	0.0	0.0	Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism.	P MITCHELL	Nature	1961	13771349	Yes
614	4383	2191.5	0.0	0.0	Pain mechanisms: a new theory.	R Melzack, P D Wall	Science	1965	5320816	No
615	4376	2188.0	100.82	50.4	Inflammation and cancer: back to Virchow?	F Balkwill, A Mantovani	Lancet	2001	11229684	No
616	2188	2188.0	0.0	0.0	[Rapid physiological coagulation method in determination of fibrinogen].	A CLAUSS	Acta Haematol	1957	13434757	Yes
617	4371	2185.5	0.0	0.0	Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain.	J Glowinski, L L Iversen	J Neurochem	1966	5950056	Yes
618	2185	2185.0	81.61	81.6	Delayed neuronal death in the gerbil hippocampus following ischemia.	T Kirino	Brain Res	1982	7093691	Yes
619	2184	2184.0	0.0	0.0	A relation between non-esterified fatty acids in plasma and the metabolism of glucose.	V P DOLE	J Clin Invest	1956	13286333	Yes
620	2182	2182.0	0.0	0.0	Measurement of pain.	E C Huskisson	Lancet	1974	4139420	Yes
621	2182	2182.0	0.0	0.0	Pharmacological implications of microsomal enzyme induction.	A H Conney	Pharmacol Rev	1967	4383307	Yes
622	4361	2180.5	114.49	57.2	High-efficiency transformation of mammalian cells by plasmid DNA.	C Chen, H Okayama	Mol Cell Biol	1987	3670292	Yes
623	6536	2178.7	129.59	43.2	Gene Expression Omnibus: NCBI gene expression and hybridization array data repository.	Ron Edgar, Michael Domrachev, Alex E Lash	Nucleic Acids Res	2002	11752295	Yes
624	2177	2177.0	59.9	59.9	Structure and function of telomeres.	E H Blackburn	Nature	1991	1708110	No
625	2177	2177.0	100.71	100.7	You want to measure coping but your protocol's too long: consider the brief COPE.	C S Carver	Int J Behav Med	1997	16250744	Yes
626	4340	2170.0	214.53	107.3	The qualitative content analysis process.	Satu Elo, Helvi Kyngäs	J Adv Nurs	2008	18352969	Yes
627	4338	2169.0	158.93	79.5	Complex network measures of brain connectivity: uses and interpretations.	Mikail Rubinov, Olaf Sporns	Neuroimage	2010	19819337	Yes
628	2167	2167.0	73.76	73.8	Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century.	M Leavitt	MedGenMed	2001	11549951	No
629	2165	2165.0	74.22	74.2	Accelerated Profile HMM Searches.	Sean R Eddy	PLoS Comput Biol	2011	22039361	Yes
630	4322	2161.0	0.0	0.0	PERIODONTAL DISEASE IN PREGNANCY. I. PREVALENCE AND SEVERITY.	H LOE, J SILNESS	Acta Odontol Scand	1963	14121956	Yes
631	2160	2160.0	87.33	87.3	What is value in health care?	Michael E Porter	N Engl J Med	2010	21142528	Yes
632	2159	2159.0	55.64	55.6	MapChart: software for the graphical presentation of linkage maps and QTLs.	R E Voorrips	J Hered	2002	12011185	Yes
633	4311	2155.5	0.0	0.0	The fluid mosaic model of the structure of cell membranes.	S J Singer, G L Nicolson	Science	1972	4333397	Yes
634	4307	2153.5	113.67	56.8	Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences.	Weizhong Li, Adam Godzik	Bioinformatics	2006	16731699	Yes
635	4300	2150.0	262.76	131.4	Revised methods for the Salmonella mutagenicity test.	D M Maron, B N Ames	Mutat Res	1983	6341825	Yes
636	2148	2148.0	57.98	58.0	Cancer nanotechnology: opportunities and challenges.	Mauro Ferrari	Nat Rev Cancer	2005	15738981	No
637	2139	2139.0	97.89	97.9	Measures of reliability in sports medicine and science.	W G Hopkins	Sports Med	2000	10907753	Yes
638	2138	2138.0	53.73	53.7	Calcium signaling.	David E Clapham	Cell	2007	18083096	No
639	4275	2137.5	158.48	79.2	Accurate and simple analytic representation of the electron-gas correlation energy.	Perdew, Wang	Phys Rev B Condens Matter	1992	10001404	Yes
640	4274	2137.0	116.39	58.2	Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis.	D Hanahan, J Folkman	Cell	1996	8756718	No
641	2132	2132.0	75.05	75.0	Implications of normal brain development for the pathogenesis of schizophrenia.	D R Weinberger	Arch Gen Psychiatry	1987	3606332	Yes
642	2130	2130.0	70.65	70.7	adegenet: a R package for the multivariate analysis of genetic markers.	Thibaut Jombart	Bioinformatics	2008	18397895	Yes
643	2129	2129.0	0.0	0.0	Colorimetric assay of catalase.	A K Sinha	Anal Biochem	1972	4556490	Yes
644	2123	2123.0	54.84	54.8	Vascular endothelial growth factor: basic science and clinical progress.	Napoleone Ferrara	Endocr Rev	2004	15294883	No
645	2122	2122.0	0.0	0.0	A protein binding assay for adenosine 3':5'-cyclic monophosphate.	A G Gilman	Proc Natl Acad Sci U S A	1970	4318781	Yes
646	2114	2114.0	0.0	0.0	Intracellular aspects of the process of protein synthesis.	G Palade	Science	1975	1096303	No
647	6341	2113.7	193.65	64.5	Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.	C M Gorman, L F Moffat, B H Howard	Mol Cell Biol	1982	6960240	Yes
648	2106	2106.0	0.0	0.0	Elastic properties of lipid bilayers: theory and possible experiments.	W Helfrich	Z Naturforsch C	1973	4273690	Yes
649	2106	2106.0	0.0	0.0	The genetical structure of populations.	S WRIGHT	Ann Eugen	1951	24540312	Yes
650	12634	2105.7	316.41	52.7	Phaser crystallographic software.	Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J Read	J Appl Crystallogr	2007	19461840	Yes
651	2102	2102.0	50.87	50.9	Angiogenesis in life, disease and medicine.	Peter Carmeliet	Nature	2005	16355210	No
652	2101	2101.0	91.59	91.6	The Danish Civil Registration System.	Carsten Bøcker Pedersen	Scand J Public Health	2011	21775345	Yes
653	2098	2098.0	39.92	39.9	Java Treeview--extensible visualization of microarray data.	Alok J Saldanha	Bioinformatics	2004	15180930	Yes
654	2098	2098.0	55.59	55.6	Causes and consequences of microRNA dysregulation in cancer.	Carlo M Croce	Nat Rev Genet	2009	19763153	No
655	4192	2096.0	88.97	44.5	Untangling the ErbB signalling network.	Y Yarden, M X Sliwkowski	Nat Rev Mol Cell Biol	2001	11252954	No
656	4174	2087.0	0.0	0.0	Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent.	J Sedlak, R H Lindsay	Anal Biochem	1968	4973948	Yes
657	2085	2085.0	0.0	0.0	Satellite cell of skeletal muscle fibers.	A MAURO	J Biophys Biochem Cytol	1961	13768451	Yes
658	2081	2081.0	43.89	43.9	Tumour-educated macrophages promote tumour progression and metastasis.	Jeffrey W Pollard	Nat Rev Cancer	2004	14708027	No
659	6234	2078.0	432.65	144.2	Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition.	P J Van Soest, J B Robertson, B A Lewis	J Dairy Sci	1991	1660498	No
660	2075	2075.0	65.95	66.0	The nerve growth factor 35 years later.	R Levi-Montalcini	Science	1987	3306916	No
661	2074	2074.0	80.33	80.3	Inositol trisphosphate and diacylglycerol: two interacting second messengers.	M J Berridge	Annu Rev Biochem	1987	3304132	No
662	2073	2073.0	56.78	56.8	Molecular basis of bacterial outer membrane permeability revisited.	Hiroshi Nikaido	Microbiol Mol Biol Rev	2003	14665678	No
663	2071	2071.0	49.13	49.1	Molecular physiology of P2X receptors.	R Alan North	Physiol Rev	2002	12270951	No
664	2070	2070.0	47.57	47.6	Evolving concepts of rheumatoid arthritis.	Gary S Firestein	Nature	2003	12748655	No
665	2064	2064.0	108.33	108.3	Qualitative research. Introducing focus groups.	J Kitzinger	BMJ	1995	7633241	Yes
666	4128	2064.0	89.85	44.9	Lipid rafts and signal transduction.	K Simons, D Toomre	Nat Rev Mol Cell Biol	2000	11413487	No
667	8238	2059.5	277.39	69.3	Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy.	Qiong Wang, George M Garrity, James M Tiedje, James R Cole	Appl Environ Microbiol	2007	17586664	Yes
668	4118	2059.0	159.53	79.8	The neural basis of drug craving: an incentive-sensitization theory of addiction.	T E Robinson, K C Berridge	Brain Res Brain Res Rev	1993	8401595	No
669	4116	2058.0	86.1	43.0	CDK inhibitors: positive and negative regulators of G1-phase progression.	C J Sherr, J M Roberts	Genes Dev	1999	10385618	No
670	6171	2057.0	0.0	0.0	Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane.	G Fairbanks, T L Steck, D F Wallach	Biochemistry	1971	4326772	Yes
671	4107	2053.5	123.37	61.7	Pattern recognition receptors and inflammation.	Osamu Takeuchi, Shizuo Akira	Cell	2010	20303872	No
672	4104	2052.0	85.75	42.9	Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell.	D Bonnet, J E Dick	Nat Med	1997	9212098	Yes
673	2051	2051.0	58.45	58.5	Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface.	G P Smith	Science	1985	4001944	Yes
674	4102	2051.0	161.64	80.8	Glutathione.	A Meister, M E Anderson	Annu Rev Biochem	1983	6137189	No
675	2050	2050.0	77.01	77.0	SF-36 health survey update.	J E Ware	Spine (Phila Pa 1976)	2000	11124729	No
676	4095	2047.5	148.37	74.2	Rapid isolation of high molecular weight plant DNA.	M G Murray, W F Thompson	Nucleic Acids Res	1980	7433111	Yes
677	8188	2047.0	249.93	62.5	GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation.	Berk Hess, Carsten Kutzner, David van der Spoel, Erik Lindahl	J Chem Theory Comput	2008	26620784	Yes
678	2043	2043.0	66.42	66.4	The anatomy and taxonomy of protein structure.	J S Richardson	Adv Protein Chem	1981	7020376	No
679	4085	2042.5	0.0	0.0	The serial cultivation of human diploid cell strains.	L HAYFLICK, P S MOORHEAD	Exp Cell Res	1961	13905658	Yes
680	2041	2041.0	60.67	60.7	The magical number 4 in short-term memory: a reconsideration of mental storage capacity.	N Cowan	Behav Brain Sci	2001	11515286	Yes
681	4076	2038.0	159.97	80.0	FLASH: fast length adjustment of short reads to improve genome assemblies.	Tanja Magoč, Steven L Salzberg	Bioinformatics	2011	21903629	Yes
682	2037	2037.0	45.31	45.3	Telomere measurement by quantitative PCR.	Richard M Cawthon	Nucleic Acids Res	2002	12000852	Yes
683	6093	2031.0	0.0	0.0	Immunochemical quantitation of antigens by single radial immunodiffusion.	G Mancini, A O Carbonara, J F Heremans	Immunochemistry	1965	4956917	Yes
684	2029	2029.0	59.51	59.5	Dietary pattern analysis: a new direction in nutritional epidemiology.	Frank B Hu	Curr Opin Lipidol	2002	11790957	No
685	2028	2028.0	72.28	72.3	What are the functional consequences of neurocognitive deficits in schizophrenia?	M F Green	Am J Psychiatry	1996	8610818	No
686	4050	2025.0	99.16	49.6	Signal integration in the endoplasmic reticulum unfolded protein response.	David Ron, Peter Walter	Nat Rev Mol Cell Biol	2007	17565364	No
687	4035	2017.5	118.81	59.4	Management of hepatocellular carcinoma.	Jordi Bruix, Morris Sherman	Hepatology	2005	16250051	No
688	2017	2017.0	0.0	0.0	A study of fixation for electron microscopy.	G E PALADE	J Exp Med	1952	14927794	Yes
689	2014	2014.0	0.0	0.0	Transduction of linked genetic characters of the host by bacteriophage P1.	E S LENNOX	Virology	1955	13267987	Yes
690	4027	2013.5	84.14	42.1	The phosphatidylinositol 3-Kinase AKT pathway in human cancer.	Igor Vivanco, Charles L Sawyers	Nat Rev Cancer	2002	12094235	No
691	2012	2012.0	53.61	53.6	A mechanism for cognitive dynamics: neuronal communication through neuronal coherence.	Pascal Fries	Trends Cogn Sci	2005	16150631	No
692	2011	2011.0	83.94	83.9	A computational approach to edge detection.	J Canny	IEEE Trans Pattern Anal Mach Intell	1986	21869365	Yes
693	2011	2011.0	114.96	115.0	Interrater reliability: the kappa statistic.	Mary L McHugh	Biochem Med (Zagreb)	2012	23092060	Yes
694	2009	2009.0	48.19	48.2	A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine.	Douglas C Wallace	Annu Rev Genet	2005	16285865	No
695	2004	2004.0	65.34	65.3	Dominant forces in protein folding.	K A Dill	Biochemistry	1990	2207096	No
696	2003	2003.0	50.34	50.3	Modularity and community structure in networks.	M E J Newman	Proc Natl Acad Sci U S A	2006	16723398	Yes
697	1999	1999.0	65.93	65.9	Two-sided confidence intervals for the single proportion: comparison of seven methods.	R G Newcombe	Stat Med	1998	9595616	Yes
698	1993	1993.0	60.14	60.1	A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data.	Heng Li	Bioinformatics	2011	21903627	Yes
699	5978	1992.7	0.0	0.0	THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.	F C GREENWOOD, W M HUNTER, J S GLOVER	Biochem J	1963	14097352	Yes
700	3981	1990.5	109.42	54.7	Reactive oxygen species: metabolism, oxidative stress, and signal transduction.	Klaus Apel, Heribert Hirt	Annu Rev Plant Biol	2004	15377225	No
701	1987	1987.0	65.4	65.4	Formation and Structure of Self-Assembled Monolayers.	Abraham Ulman	Chem Rev	1996	11848802	Yes
702	1985	1985.0	78.75	78.8	Working memory.	A Baddeley	Science	1992	1736359	No
703	1985	1985.0	80.87	80.9	Matrix metalloproteinases and their inhibitors in connective tissue remodeling.	J F Woessner	FASEB J	1991	1850705	No
704	5952	1984.0	355.2	118.4	Deep learning.	Yann LeCun, Yoshua Bengio, Geoffrey Hinton	Nature	2015	26017442	No
705	3966	1983.0	149.15	74.6	Inositol trisphosphate, a novel second messenger in cellular signal transduction.	M J Berridge, R F Irvine	Nature	1984	6095092	No
706	5946	1982.0	166.76	55.6	RNA-Seq: a revolutionary tool for transcriptomics.	Zhong Wang, Mark Gerstein, Michael Snyder	Nat Rev Genet	2009	19015660	No
707	1980	1980.0	67.43	67.4	Scaffolds in tissue engineering bone and cartilage.	D W Hutmacher	Biomaterials	2000	11071603	Yes
708	5938	1979.3	196.25	65.4	Bacterial biofilms: a common cause of persistent infections.	J W Costerton, P S Stewart, E P Greenberg	Science	1999	10334980	No
709	1979	1979.0	46.0	46.0	NOX enzymes and the biology of reactive oxygen.	J David Lambeth	Nat Rev Immunol	2004	15039755	No
710	1977	1977.0	0.0	0.0	A rapid radiochemical method for the determination of choline acetyltransferase.	F Fonnum	J Neurochem	1975	1113118	Yes
711	1977	1977.0	74.34	74.3	An empirical correction for absorption anisotropy.	R H Blessing	Acta Crystallogr A	1995	7702794	Yes
712	3952	1976.0	0.0	0.0	A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.	S REITMAN, S FRANKEL	Am J Clin Pathol	1957	13458125	Yes
713	3951	1975.5	164.1	82.0	The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions.	S H Downs, N Black	J Epidemiol Community Health	1998	9764259	Yes
714	1972	1972.0	0.0	0.0	The gel-filtration behaviour of proteins related to their molecular weights over a wide range.	P Andrews	Biochem J	1965	5862401	Yes
715	1972	1972.0	56.47	56.5	Immunological and inflammatory functions of the interleukin-1 family.	Charles A Dinarello	Annu Rev Immunol	2009	19302047	No
716	3943	1971.5	82.76	41.4	Mechanisms of TGF-beta signaling from cell membrane to the nucleus.	Yigong Shi, Joan Massagué	Cell	2003	12809600	No
717	1969	1969.0	41.96	42.0	The molecular biology of memory storage: a dialogue between genes and synapses.	E R Kandel	Science	2001	11691980	No
718	5905	1968.3	0.0	0.0	The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum.	R J HAVEL, H A EDER, J H BRAGDON	J Clin Invest	1955	13252080	Yes
719	3935	1967.5	422.07	211.0	A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research.	Terry K Koo, Mae Y Li	J Chiropr Med	2016	27330520	Yes
720	1965	1965.0	38.38	38.4	Targeting RAS signalling pathways in cancer therapy.	Julian Downward	Nat Rev Cancer	2003	12509763	No
721	1959	1959.0	62.67	62.7	Physiology and neurobiology of stress and adaptation: central role of the brain.	Bruce S McEwen	Physiol Rev	2007	17615391	No
722	1959	1959.0	119.98	120.0	Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs.	Daniël Lakens	Front Psychol	2013	24324449	No
723	3917	1958.5	90.58	45.3	New functions for the matrix metalloproteinases in cancer progression.	Mikala Egeblad, Zena Werb	Nat Rev Cancer	2002	11990853	No
724	3913	1956.5	157.74	78.9	The L-arginine-nitric oxide pathway.	S Moncada, A Higgs	N Engl J Med	1993	7504210	No
725	1956	1956.0	75.46	75.5	Ethical authorship and publishing.	Andrew J S Coats	Int J Cardiol	2009	19046787	No
726	3908	1954.0	0.0	0.0	A general method applicable to the search for similarities in the amino acid sequence of two proteins.	S B Needleman, C D Wunsch	J Mol Biol	1970	5420325	Yes
727	1954	1954.0	53.41	53.4	Ischemic cell death in brain neurons.	P Lipton	Physiol Rev	1999	10508238	No
728	3903	1951.5	202.66	101.3	phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data.	Paul J McMurdie, Susan Holmes	PLoS One	2013	23630581	Yes
729	3897	1948.5	116.83	58.4	Calculation of protein extinction coefficients from amino acid sequence data.	S C Gill, P H von Hippel	Anal Biochem	1989	2610349	Yes
730	1948	1948.0	74.3	74.3	DNA methylation age of human tissues and cell types.	Steve Horvath	Genome Biol	2013	24138928	Yes
731	3890	1945.0	88.26	44.1	A novel genetic system to detect protein-protein interactions.	S Fields, O Song	Nature	1989	2547163	Yes
732	3888	1944.0	0.0	0.0	Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.	L A Greene, A S Tischler	Proc Natl Acad Sci U S A	1976	1065897	Yes
733	3887	1943.5	108.06	54.0	A global optimisation method for robust affine registration of brain images.	M Jenkinson, S Smith	Med Image Anal	2001	11516708	Yes
734	5828	1942.7	144.1	48.0	The biology of VEGF and its receptors.	Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter	Nat Med	2003	12778165	No
735	1942	1942.0	0.0	0.0	Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method.	L SVENNERHOLM	Biochim Biophys Acta	1957	13436486	Yes
736	3881	1940.5	182.1	91.0	A feature-integration theory of attention.	A M Treisman, G Gelade	Cogn Psychol	1980	7351125	Yes
737	3881	1940.5	101.8	50.9	Protein misfolding, functional amyloid, and human disease.	Fabrizio Chiti, Christopher M Dobson	Annu Rev Biochem	2006	16756495	No
738	5815	1938.3	305.27	101.8	Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale.	J L Cox, J M Holden, R Sagovsky	Br J Psychiatry	1987	3651732	Yes
739	1931	1931.0	47.1	47.1	Mitochondrial diseases in man and mouse.	D C Wallace	Science	1999	10066162	No
740	3860	1930.0	93.83	46.9	AKT/PKB signaling: navigating downstream.	Brendan D Manning, Lewis C Cantley	Cell	2007	17604717	No
741	3856	1928.0	95.2	47.6	Death receptors: signaling and modulation.	A Ashkenazi, V M Dixit	Science	1998	9721089	No
742	1925	1925.0	65.88	65.9	Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples.	Peter C Austin	Stat Med	2009	19757444	Yes
743	5766	1922.0	182.19	60.7	Quantum mechanical continuum solvation models.	Jacopo Tomasi, Benedetta Mennucci, Roberto Cammi	Chem Rev	2005	16092826	Yes
744	1919	1919.0	67.83	67.8	Biodiesel from microalgae.	Yusuf Chisti	Biotechnol Adv	2007	17350212	No
745	1918	1918.0	47.86	47.9	G1 phase progression: cycling on cue.	C J Sherr	Cell	1994	7954821	No
746	3826	1913.0	0.0	0.0	A modified uronic acid carbazole reaction.	T BITTER, H M MUIR	Anal Biochem	1962	13971270	Yes
747	1912	1912.0	70.76	70.8	A two process model of sleep regulation.	A A Borbély	Hum Neurobiol	1982	7185792	Yes
748	1910	1910.0	47.28	47.3	Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling.	T Hunter	Cell	1995	7834742	No
749	5729	1909.7	157.69	52.6	ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data.	Kai Wang, Mingyao Li, Hakon Hakonarson	Nucleic Acids Res	2010	20601685	Yes
750	3816	1908.0	126.11	63.1	Neural mechanisms of selective visual attention.	R Desimone, J Duncan	Annu Rev Neurosci	1995	7605061	No
751	1907	1907.0	45.17	45.2	Universal control mechanism regulating onset of M-phase.	P Nurse	Nature	1990	2138713	No
752	1906	1906.0	97.49	97.5	Effective physician-patient communication and health outcomes: a review.	M A Stewart	CMAJ	1995	7728691	Yes
753	1903	1903.0	57.8	57.8	Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity.	E C Butcher	Cell	1991	1760836	No
754	3805	1902.5	0.0	0.0	Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid.	J D WATSON, F H CRICK	Nature	1953	13054692	Yes
755	3804	1902.0	107.69	53.8	The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.	Karen Bedard, Karl-Heinz Krause	Physiol Rev	2007	17237347	No
756	1902	1902.0	59.69	59.7	Efficient methods to compute genomic predictions.	P M VanRaden	J Dairy Sci	2008	18946147	Yes
757	3795	1897.5	115.98	58.0	Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging.	Michael D Fox, Marcus E Raichle	Nat Rev Neurosci	2007	17704812	No
758	3790	1895.0	103.77	51.9	Nonparametric permutation tests for functional neuroimaging: a primer with examples.	Thomas E Nichols, Andrew P Holmes	Hum Brain Mapp	2002	11747097	Yes
759	3788	1894.0	100.85	50.4	Myeloid-derived suppressor cells as regulators of the immune system.	Dmitry I Gabrilovich, Srinivas Nagaraj	Nat Rev Immunol	2009	19197294	No
760	1893	1893.0	61.09	61.1	Hybrid porous solids: past, present, future.	Gérard Férey	Chem Soc Rev	2008	18197340	Yes
761	1890	1890.0	0.0	0.0	On estimating the relation between blood group and disease.	B WOOLF	Ann Hum Genet	1955	14388528	Yes
762	3776	1888.0	88.25	44.1	Mass spectrometry-based proteomics.	Ruedi Aebersold, Matthias Mann	Nature	2003	12634793	No
763	1887	1887.0	46.83	46.8	Rab GTPases as coordinators of vesicle traffic.	Harald Stenmark	Nat Rev Mol Cell Biol	2009	19603039	No
764	1885	1885.0	0.0	0.0	A RAPID PERMETHYLATION OF GLYCOLIPID, AND POLYSACCHARIDE CATALYZED BY METHYLSULFINYL CARBANION IN DIMETHYL SULFOXIDE.	S HAKOMORI	J Biochem	1964	14135466	Yes
765	3762	1881.0	126.61	63.3	Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9167458	Yes
766	1877	1877.0	43.01	43.0	Cisplatin: mode of cytotoxic action and molecular basis of resistance.	Zahid H Siddik	Oncogene	2003	14576837	No
767	1876	1876.0	49.65	49.6	Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens.	Jane Glazebrook	Annu Rev Phytopathol	2005	16078883	No
768	3748	1874.0	174.35	87.2	Self-rated health and mortality: a review of twenty-seven community studies.	E L Idler, Y Benyamini	J Health Soc Behav	1997	9097506	No
769	1874	1874.0	61.3	61.3	Parkinson's disease: clinical features and diagnosis.	J Jankovic	J Neurol Neurosurg Psychiatry	2008	18344392	No
770	1869	1869.0	52.86	52.9	Biology of natural killer cells.	G Trinchieri	Adv Immunol	1989	2683611	No
771	1869	1869.0	37.03	37.0	Histone acetylation in chromatin structure and transcription.	M Grunstein	Nature	1997	9311776	No
772	1867	1867.0	37.99	38.0	NK cell recognition.	Lewis L Lanier	Annu Rev Immunol	2005	15771571	No
773	3728	1864.0	106.51	53.3	UniFrac: a new phylogenetic method for comparing microbial communities.	Catherine Lozupone, Rob Knight	Appl Environ Microbiol	2005	16332807	Yes
774	1861	1861.0	63.47	63.5	Japanese Classification of Gastric Carcinoma - 2nd English Edition -	Japanese Gastric Cancer Association	Gastric Cancer	1998	11957040	Yes
775	1859	1859.0	90.37	90.4	Central sensitization: implications for the diagnosis and treatment of pain.	Clifford J Woolf	Pain	2011	20961685	No
776	1858	1858.0	0.0	0.0	A RATIONALE AND TEST FOR THE NUMBER OF FACTORS IN FACTOR ANALYSIS.	J L HORN	Psychometrika	1965	14306381	Yes
777	1856	1856.0	0.0	0.0	The information capacity of the human motor system in controlling the amplitude of movement.	P M FITTS	J Exp Psychol	1954	13174710	Yes
778	1854	1854.0	45.01	45.0	Complement. First of two parts.	M J Walport	N Engl J Med	2001	11287977	No
779	1854	1854.0	40.99	41.0	Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self.	Shimon Sakaguchi	Nat Immunol	2005	15785760	No
780	1853	1853.0	37.23	37.2	Shelterin: the protein complex that shapes and safeguards human telomeres.	Titia de Lange	Genes Dev	2005	16166375	No
781	1852	1852.0	63.37	63.4	Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention.	P Correa	Cancer Res	1992	1458460	No
782	1852	1852.0	0.0	0.0	A simple technique for demonstrating centromeric heterochromatin.	A T Sumner	Exp Cell Res	1972	4117921	Yes
783	1852	1852.0	46.6	46.6	Chemokines and leukocyte traffic.	M Baggiolini	Nature	1998	9560152	No
784	1848	1848.0	0.0	0.0	The biology of oxygen radicals.	I Fridovich	Science	1978	210504	Yes
785	1846	1846.0	61.11	61.1	Stress, adaptation, and disease. Allostasis and allostatic load.	B S McEwen	Ann N Y Acad Sci	1998	9629234	No
786	1844	1844.0	72.71	72.7	Reactive oxygen species and the central nervous system.	B Halliwell	J Neurochem	1992	1402908	No
787	1844	1844.0	64.9	64.9	The unfolded protein response: controlling cell fate decisions under ER stress and beyond.	Claudio Hetz	Nat Rev Mol Cell Biol	2012	22251901	No
788	3687	1843.5	0.0	0.0	Screening lambdagt recombinant clones by hybridization to single plaques in situ.	W D Benton, R W Davis	Science	1977	322279	Yes
789	1843	1843.0	78.57	78.6	Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.	B Samuelsson	Science	1983	6301011	Yes
790	1842	1842.0	0.0	0.0	Isolation by Distance.	S Wright	Genetics	1943	17247074	Yes
791	3683	1841.5	114.32	57.2	Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up.	C W Elston, I O Ellis	Histopathology	1991	1757079	Yes
792	1839	1839.0	58.32	58.3	The episodic buffer: a new component of working memory?	Baddeley	Trends Cogn Sci	2000	11058819	Yes
793	1839	1839.0	56.14	56.1	Pancreatic cancer.	Manuel Hidalgo	N Engl J Med	2010	20427809	No
794	5514	1838.0	157.16	52.4	Cortical surface-based analysis. I. Segmentation and surface reconstruction.	A M Dale, B Fischl, M I Sereno	Neuroimage	1999	9931268	Yes
795	1836	1836.0	43.61	43.6	Nitric oxide and the immune response.	C Bogdan	Nat Immunol	2001	11577346	No
796	3665	1832.5	153.43	76.7	Random-effects models for longitudinal data.	N M Laird, J H Ware	Biometrics	1982	7168798	Yes
797	1828	1828.0	85.73	85.7	Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals.	H W Steinbusch	Neuroscience	1981	7017455	Yes
798	1826	1826.0	50.58	50.6	RGD and other recognition sequences for integrins.	E Ruoslahti	Annu Rev Cell Dev Biol	1996	8970741	No
799	3651	1825.5	106.54	53.3	Acute-phase proteins and other systemic responses to inflammation.	C Gabay, I Kushner	N Engl J Med	1999	9971870	No
800	1825	1825.0	49.47	49.5	Inferring the historical patterns of biological evolution.	M Pagel	Nature	1999	10553904	Yes
801	1824	1824.0	49.39	49.4	SV40-transformed simian cells support the replication of early SV40 mutants.	Y Gluzman	Cell	1981	6260373	Yes
802	1821	1821.0	74.78	74.8	Role of oxidative stress in development of complications in diabetes.	J W Baynes	Diabetes	1991	2010041	No
803	1820	1820.0	62.42	62.4	Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose.	J Kyhse-Andersen	J Biochem Biophys Methods	1984	6530509	Yes
804	1816	1816.0	49.18	49.2	Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences.	Edward V Loftus	Gastroenterology	2004	15168363	Yes
805	1815	1815.0	54.99	55.0	Descending control of pain.	Mark J Millan	Prog Neurobiol	2002	12034378	No
806	1815	1815.0	48.02	48.0	The inflammatory reflex.	Kevin J Tracey	Nature	2002	12490958	No
807	3628	1814.0	108.77	54.4	Application of phylogenetic networks in evolutionary studies.	Daniel H Huson, David Bryant	Mol Biol Evol	2006	16221896	Yes
808	5441	1813.7	111.17	37.1	Control of regulatory T cell development by the transcription factor Foxp3.	Shohei Hori, Takashi Nomura, Shimon Sakaguchi	Science	2003	12522256	Yes
809	7254	1813.5	172.92	43.2	Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.	A Krogh, B Larsson, G von Heijne, E L Sonnhammer	J Mol Biol	2001	11152613	Yes
810	5438	1812.7	166.99	55.7	Immunity, inflammation, and cancer.	Sergei I Grivennikov, Florian R Greten, Michael Karin	Cell	2010	20303878	No
811	3625	1812.5	0.0	0.0	The interpretation of protein structures: estimation of static accessibility.	B Lee, F M Richards	J Mol Biol	1971	5551392	Yes
812	1811	1811.0	54.89	54.9	A model for receptor-regulated calcium entry.	J W Putney	Cell Calcium	1986	2420465	No
813	1811	1811.0	50.83	50.8	T cell exhaustion.	E John Wherry	Nat Immunol	2011	21739672	No
814	1810	1810.0	60.1	60.1	Determination and analysis of urea and guanidine hydrochloride denaturation curves.	C N Pace	Methods Enzymol	1986	3773761	Yes
815	1810	1810.0	45.86	45.9	The regulation of AP-1 activity by mitogen-activated protein kinases.	M Karin	J Biol Chem	1995	7622446	No
816	3616	1808.0	93.34	46.7	The Bcl-2 protein family: arbiters of cell survival.	J M Adams, S Cory	Science	1998	9735050	No
817	3613	1806.5	101.37	50.7	Signal transduction by receptors with tyrosine kinase activity.	A Ullrich, J Schlessinger	Cell	1990	2158859	No
818	3613	1806.5	88.78	44.4	Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.	F Sallusto, A Lanzavecchia	J Exp Med	1994	8145033	Yes
819	5418	1806.0	139.52	46.5	MOLMOL: a program for display and analysis of macromolecular structures.	R Koradi, M Billeter, K Wüthrich	J Mol Graph	1996	8744573	Yes
820	1806	1806.0	71.58	71.6	Epidemiology of viral hepatitis and hepatocellular carcinoma.	Hashem B El-Serag	Gastroenterology	2012	22537432	No
821	1802	1802.0	71.29	71.3	Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men.	W A Craig	Clin Infect Dis	1998	9455502	No
822	10809	1801.5	257.9	43.0	NMRPipe: a multidimensional spectral processing system based on UNIX pipes.	F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A Bax	J Biomol NMR	1995	8520220	Yes
823	1801	1801.0	63.76	63.8	Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication.	H G Gratzner	Science	1982	7123245	Yes
824	1800	1800.0	72.48	72.5	Spinal and supraspinal factors in human muscle fatigue.	S C Gandevia	Physiol Rev	2001	11581501	No
825	1798	1798.0	58.58	58.6	A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.	P Chomczynski	Biotechniques	1993	7692896	Yes
826	10779	1796.5	403.07	67.2	Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.	Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell Parkin	Int J Cancer	2010	21351269	Yes
827	1796	1796.0	52.43	52.4	Working memory: looking back and looking forward.	Alan Baddeley	Nat Rev Neurosci	2003	14523382	No
828	1796	1796.0	37.27	37.3	Mechanisms of type-I- and type-II-interferon-mediated signalling.	Leonidas C Platanias	Nat Rev Immunol	2005	15864272	No
829	1796	1796.0	55.13	55.1	The nuclear factor NF-kappaB pathway in inflammation.	Toby Lawrence	Cold Spring Harb Perspect Biol	2009	20457564	No
830	3590	1795.0	0.0	0.0	Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.	T V Bliss, T Lomo	J Physiol	1973	4727084	Yes
831	3582	1791.0	117.05	58.5	The number of people with glaucoma worldwide in 2010 and 2020.	H A Quigley, A T Broman	Br J Ophthalmol	2006	16488940	Yes
832	1791	1791.0	55.85	55.9	Carbonic anhydrases: novel therapeutic applications for inhibitors and activators.	Claudiu T Supuran	Nat Rev Drug Discov	2008	18167490	No
833	3580	1790.0	131.26	65.6	Missing data: our view of the state of the art.	Joseph L Schafer, John W Graham	Psychol Methods	2002	12090408	Yes
834	3578	1789.0	199.45	99.7	Clinical significance: a statistical approach to defining meaningful change in psychotherapy research.	N S Jacobson, P Truax	J Consult Clin Psychol	1991	2002127	Yes
835	3578	1789.0	178.38	89.2	A simple, rapid, and sensitive DNA assay procedure.	C Labarca, K Paigen	Anal Biochem	1980	6158890	Yes
836	1788	1788.0	48.27	48.3	Specification of cerebral cortical areas.	P Rakic	Science	1988	3291116	No
837	3576	1788.0	95.77	47.9	Hepatocellular carcinoma: epidemiology and molecular carcinogenesis.	Hashem B El-Serag, K Lenhard Rudolph	Gastroenterology	2007	17570226	No
838	3573	1786.5	73.52	36.8	Network biology: understanding the cell's functional organization.	Albert-László Barabási, Zoltán N Oltvai	Nat Rev Genet	2004	14735121	No
839	1785	1785.0	80.31	80.3	Glutamate, nitric oxide and cell-cell signalling in the nervous system.	J Garthwaite	Trends Neurosci	1991	1708538	No
840	1784	1784.0	74.11	74.1	Qualitative research: standards, challenges, and guidelines.	K Malterud	Lancet	2001	11513933	Yes
841	3562	1781.0	77.93	39.0	Mammalian MAP kinase signalling cascades.	L Chang, M Karin	Nature	2001	11242034	No
842	3561	1780.5	0.0	0.0	The Social Readjustment Rating Scale.	T H Holmes, R H Rahe	J Psychosom Res	1967	6059863	Yes
843	1780	1780.0	0.0	0.0	Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli.	G BERTANI	J Bacteriol	1951	14888646	Yes
844	3555	1777.5	138.12	69.1	Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being.	R M Ryan, E L Deci	Am Psychol	2000	11392867	Yes
845	1776	1776.0	0.0	0.0	Catheter replacement of the needle in percutaneous arteriography; a new technique.	S I SELDINGER	Acta radiol	1953	13057644	Yes
846	3551	1775.5	103.51	51.8	Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results.	E Lander, L Kruglyak	Nat Genet	1995	7581446	Yes
847	1775	1775.0	54.17	54.2	The heme oxygenase system: a regulator of second messenger gases.	M D Maines	Annu Rev Pharmacol Toxicol	1997	9131263	No
848	1775	1775.0	104.68	104.7	Structural Model Evaluation and Modification: An Interval Estimation Approach.	J H Steiger	Multivariate Behav Res	1990	26794479	Yes
849	7092	1773.0	189.46	47.4	Matrix elasticity directs stem cell lineage specification.	Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E Discher	Cell	2006	16923388	Yes
850	3543	1771.5	121.61	60.8	Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly.	J S Beckman, W H Koppenol	Am J Physiol	1996	8944624	No
851	3541	1770.5	0.0	0.0	The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase.	H P Misra, I Fridovich	J Biol Chem	1972	4623845	Yes
852	3538	1769.0	0.0	0.0	Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography.	R A Laskey, A D Mills	Eur J Biochem	1975	1175627	Yes
853	1767	1767.0	0.0	0.0	Stereochemistry of cooperative effects in haemoglobin.	M F Perutz	Nature	1970	5528785	Yes
854	1767	1767.0	68.32	68.3	The unbiased estimation of number and sizes of arbitrary particles using the disector.	D C Sterio	J Microsc	1984	6737468	Yes
855	3532	1766.0	101.99	51.0	Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology.	Marie-Christine Daniel, Didier Astruc	Chem Rev	2004	14719978	No
856	3530	1765.0	102.6	51.3	Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.	M Matsuda, R A DeFronzo	Diabetes Care	1999	10480510	Yes
857	3523	1761.5	149.51	74.8	Extracellular vesicles: exosomes, microvesicles, and friends.	Graça Raposo, Willem Stoorvogel	J Cell Biol	2013	23420871	No
858	14080	1760.0	552.21	69.0	The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.	D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C Siebert	N Engl J Med	1993	8366922	Yes
859	1760	1760.0	57.56	57.6	Estimating causal effects from large data sets using propensity scores.	D B Rubin	Ann Intern Med	1997	9382394	No
860	1758	1758.0	0.0	0.0	Muscle structure and theories of contraction.	A F HUXLEY	Prog Biophys Biophys Chem	1957	13485191	Yes
861	3513	1756.5	87.06	43.5	Brown adipose tissue: function and physiological significance.	Barbara Cannon, Jan Nedergaard	Physiol Rev	2004	14715917	No
862	3510	1755.0	120.82	60.4	Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections.	Jeng-Da Chai, Martin Head-Gordon	Phys Chem Chem Phys	2008	18989472	Yes
863	1753	1753.0	0.0	0.0	The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes.	S BOYDEN	J Exp Med	1962	13872176	Yes
864	1753	1753.0	50.94	50.9	Accurate description of van der Waals complexes by density functional theory including empirical corrections.	Stefan Grimme	J Comput Chem	2004	15224390	Yes
865	1753	1753.0	81.64	81.6	Missing data analysis: making it work in the real world.	John W Graham	Annu Rev Psychol	2009	18652544	No
866	5257	1752.3	0.0	0.0	ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.	J MONOD, J WYMAN, J P CHANGEUX	J Mol Biol	1965	14343300	Yes
867	3503	1751.5	124.25	62.1	SPSS and SAS procedures for estimating indirect effects in simple mediation models.	Kristopher J Preacher, Andrew F Hayes	Behav Res Methods Instrum Comput	2004	15641418	Yes
868	5254	1751.3	244.63	81.5	Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA.	G Muyzer, E C de Waal, A G Uitterlinden	Appl Environ Microbiol	1993	7683183	Yes
869	3501	1750.5	131.92	66.0	A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.	Gary J Bennett, Y-K Xie	Pain	1988	2837713	Yes
870	1750	1750.0	0.0	0.0	SEDIMENTATION STUDIES OF THE SIZE AND SHAPE OF DNA.	F W STUDIER	J Mol Biol	1965	14290352	Yes
871	3495	1747.5	0.0	0.0	A method for determining the sedimentation behavior of enzymes: application to protein mixtures.	R G MARTIN, B N AMES	J Biol Chem	1961	13767412	Yes
872	15726	1747.3	1043.82	116.0	Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.	Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray	Int J Cancer	2015	25220842	Yes
873	1747	1747.0	0.0	0.0	Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters.	F F Jöbsis	Science	1977	929199	Yes
874	1746	1746.0	78.54	78.5	International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results.	C Herrmann	J Psychosom Res	1997	9055211	No
875	1745	1745.0	47.02	47.0	Negative refraction makes a perfect lens	Pendry	Phys Rev Lett	2000	11041972	Yes
876	1744	1744.0	70.27	70.3	A classification of glycosyl hydrolases based on amino acid sequence similarities.	B Henrissat	Biochem J	1991	1747104	Yes
877	10450	1741.7	333.51	55.6	A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group.	A S Levey, J P Bosch, J B Lewis, T Greene, N Rogers, D Roth	Ann Intern Med	1999	10075613	Yes
878	1741	1741.0	59.81	59.8	Molecular diversity of glutamate receptors and implications for brain function.	S Nakanishi	Science	1992	1329206	No
879	1738	1738.0	0.0	0.0	Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads.	P Cuatrecasas	J Biol Chem	1970	5432796	Yes
880	1738	1738.0	32.24	32.2	ATM and related protein kinases: safeguarding genome integrity.	Yosef Shiloh	Nat Rev Cancer	2003	12612651	No
881	1736	1736.0	47.33	47.3	Social controls on cell survival and cell death.	M C Raff	Nature	1992	1557121	No
882	1735	1735.0	45.12	45.1	Animal mitochondrial genomes.	J L Boore	Nucleic Acids Res	1999	10101183	No
883	3470	1735.0	72.36	36.2	The Wnt signaling pathway in development and disease.	Catriona Y Logan, Roel Nusse	Annu Rev Cell Dev Biol	2004	15473860	No
884	1733	1733.0	41.85	41.9	A clearer vision for in vivo imaging.	R Weissleder	Nat Biotechnol	2001	11283581	No
885	1733	1733.0	43.87	43.9	Pathways towards and away from Alzheimer's disease.	Mark P Mattson	Nature	2004	15295589	No
886	3465	1732.5	72.31	36.2	Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals.	Rudolf Jaenisch, Adrian Bird	Nat Genet	2003	12610534	No
887	3464	1732.0	91.72	45.9	Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.	B A Reynolds, S Weiss	Science	1992	1553558	Yes
888	1732	1732.0	51.54	51.5	The blood-brain barrier in health and chronic neurodegenerative disorders.	Berislav V Zlokovic	Neuron	2008	18215617	No
889	1731	1731.0	55.84	55.8	Superoxide radical and superoxide dismutases.	I Fridovich	Annu Rev Biochem	1995	7574505	No
890	1731	1731.0	0.0	0.0	On respiratory impairment in cancer cells.	O WARBURG	Science	1956	13351639	Yes
891	1730	1730.0	40.62	40.6	Theta oscillations in the hippocampus.	György Buzsáki	Neuron	2002	11832222	No
892	1729	1729.0	66.04	66.0	Eye movements in reading and information processing: 20 years of research.	K Rayner	Psychol Bull	1998	9849112	No
893	5182	1727.3	112.83	37.6	EMBOSS: the European Molecular Biology Open Software Suite.	P Rice, I Longden, A Bleasby	Trends Genet	2000	10827456	Yes
894	1725	1725.0	38.58	38.6	Molecular bases for circadian clocks.	J C Dunlap	Cell	1999	9988221	No
895	1724	1724.0	55.39	55.4	The importance of selenium to human health.	M P Rayman	Lancet	2000	10963212	No
896	1724	1724.0	37.28	37.3	CpG motifs in bacterial DNA and their immune effects.	Arthur M Krieg	Annu Rev Immunol	2002	11861616	No
897	3445	1722.5	79.11	39.6	Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.	M Gossen, H Bujard	Proc Natl Acad Sci U S A	1992	1319065	Yes
898	1722	1722.0	0.0	0.0	MECHANISM OF SUSTAINED-ACTION MEDICATION. THEORETICAL ANALYSIS OF RATE OF RELEASE OF SOLID DRUGS DISPERSED IN SOLID MATRICES.	T HIGUCHI	J Pharm Sci	1963	14088963	Yes
899	3443	1721.5	110.48	55.2	A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.	Y Matsumura, H Maeda	Cancer Res	1986	2946403	Yes
900	5164	1721.3	145.34	48.4	Canonical sampling through velocity rescaling.	Giovanni Bussi, Davide Donadio, Michele Parrinello	J Chem Phys	2007	17212484	Yes
901	1721	1721.0	47.26	47.3	Dopamine, learning and motivation.	Roy A Wise	Nat Rev Neurosci	2004	15152198	No
902	3440	1720.0	147.84	73.9	The attention system of the human brain.	M I Posner, S E Petersen	Annu Rev Neurosci	1990	2183676	No
903	1718	1718.0	32.14	32.1	Automated electron microscope tomography using robust prediction of specimen movements.	David N Mastronarde	J Struct Biol	2005	16182563	Yes
904	3434	1717.0	72.67	36.3	Smad-dependent and Smad-independent pathways in TGF-beta family signalling.	Rik Derynck, Ying E Zhang	Nature	2003	14534577	No
905	1714	1714.0	60.16	60.2	Hazards of heavy metal contamination.	Lars Järup	Br Med Bull	2003	14757716	No
906	1713	1713.0	41.33	41.3	Defensins: antimicrobial peptides of innate immunity.	Tomas Ganz	Nat Rev Immunol	2003	12949495	No
907	15398	1710.9	342.57	38.1	Cytoscape: a software environment for integrated models of biomolecular interaction networks.	Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey Ideker	Genome Res	2003	14597658	Yes
908	1710	1710.0	37.92	37.9	Metastasis to bone: causes, consequences and therapeutic opportunities.	Gregory R Mundy	Nat Rev Cancer	2002	12154351	No
909	1709	1709.0	70.37	70.4	Human error: models and management.	J Reason	BMJ	2000	10720363	Yes
910	1708	1708.0	43.84	43.8	A decade of molecular biology of retinoic acid receptors.	P Chambon	FASEB J	1996	8801176	No
911	1707	1707.0	40.08	40.1	XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density.	D E McRee	J Struct Biol	1999	10222271	Yes
912	1705	1705.0	0.0	0.0	The Michigan alcoholism screening test: the quest for a new diagnostic instrument.	M L Selzer	Am J Psychiatry	1971	5565851	Yes
913	1705	1705.0	61.62	61.6	Fetal origins of coronary heart disease.	D J Barker	BMJ	1995	7613432	No
914	1705	1705.0	51.74	51.7	Accurate Coulomb-fitting basis sets for H to Rn.	Florian Weigend	Phys Chem Chem Phys	2006	16633586	Yes
915	1703	1703.0	60.88	60.9	The free-energy principle: a unified brain theory?	Karl Friston	Nat Rev Neurosci	2010	20068583	No
916	5107	1702.3	172.54	57.5	The brain's default network: anatomy, function, and relevance to disease.	Randy L Buckner, Jessica R Andrews-Hanna, Daniel L Schacter	Ann N Y Acad Sci	2008	18400922	No
917	1701	1701.0	52.47	52.5	Epidemiology of insomnia: what we know and what we still need to learn.	Maurice M Ohayon	Sleep Med Rev	2002	12531146	Yes
918	5101	1700.3	128.66	42.9	APE: Analyses of Phylogenetics and Evolution in R language.	Emmanuel Paradis, Julien Claude, Korbinian Strimmer	Bioinformatics	2004	14734327	Yes
919	1699	1699.0	0.0	0.0	The membrane actions of anesthetics and tranquilizers.	P Seeman	Pharmacol Rev	1972	4565956	No
920	1698	1698.0	49.26	49.3	Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details.	R D Pascual-Marqui	Methods Find Exp Clin Pharmacol	2002	12575463	No
921	3395	1697.5	104.85	52.4	Organization and expression of eucaryotic split genes coding for proteins.	R Breathnach, P Chambon	Annu Rev Biochem	1981	6791577	No
922	1697	1697.0	36.78	36.8	The complex language of chromatin regulation during transcription.	Shelley L Berger	Nature	2007	17522673	No
923	1696	1696.0	69.35	69.3	Simplified calculation of body-surface area.	R D Mosteller	N Engl J Med	1987	3657876	Yes
924	1696	1696.0	78.0	78.0	Specific impairments of planning.	T Shallice	Philos Trans R Soc Lond B Biol Sci	1982	6125971	Yes
925	1695	1695.0	37.19	37.2	Approaching the asymptote? Evolution and revolution in immunology.	C A Janeway	Cold Spring Harb Symp Quant Biol	1989	2700931	No
926	1695	1695.0	0.0	0.0	Protein denaturation.	C Tanford	Adv Protein Chem	1968	4882248	No
927	1695	1695.0	31.72	31.7	Mechanisms of alternative pre-messenger RNA splicing.	Douglas L Black	Annu Rev Biochem	2003	12626338	No
928	1695	1695.0	48.18	48.2	Mechanisms of hepatic fibrogenesis.	Scott L Friedman	Gastroenterology	2008	18471545	No
929	3388	1694.0	102.98	51.5	Alzheimer's disease: the amyloid cascade hypothesis.	J A Hardy, G A Higgins	Science	1992	1566067	No
930	5082	1694.0	184.56	61.5	Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders.	C Lord, M Rutter, A Le Couteur	J Autism Dev Disord	1994	7814313	Yes
931	3388	1694.0	89.23	44.6	The acute respiratory distress syndrome.	L B Ware, M A Matthay	N Engl J Med	2000	10793167	No
932	1694	1694.0	50.44	50.4	Endoplasmic reticulum stress and the inflammatory basis of metabolic disease.	Gökhan S Hotamisligil	Cell	2010	20303879	No
933	5079	1693.0	179.76	59.9	Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.	C E Murry, R B Jennings, K A Reimer	Circulation	1986	3769170	Yes
934	1692	1692.0	57.4	57.4	TGFβ signalling in context.	Joan Massagué	Nat Rev Mol Cell Biol	2012	22992590	No
935	3382	1691.0	100.96	50.5	Function and activation of NF-kappa B in the immune system.	P A Baeuerle, T Henkel	Annu Rev Immunol	1994	8011280	No
936	3381	1690.5	90.7	45.4	Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.	Michael T Lin, M Flint Beal	Nature	2006	17051205	No
937	1690	1690.0	71.44	71.4	Secretory products of macrophages.	C F Nathan	J Clin Invest	1987	3543052	No
938	3380	1690.0	94.37	47.2	Cutaneous wound healing.	A J Singer, R A Clark	N Engl J Med	1999	10471461	No
939	11824	1689.1	287.69	41.1	Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes.	Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman	Genome Biol	2002	12184808	Yes
940	3376	1688.0	202.39	101.2	Stress, social support, and the buffering hypothesis.	S Cohen, T A Wills	Psychol Bull	1985	3901065	No
941	3371	1685.5	0.0	0.0	Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid.	A C Chang, S N Cohen	J Bacteriol	1978	149110	Yes
942	3370	1685.0	69.01	34.5	The fundamental role of epigenetic events in cancer.	Peter A Jones, Stephen B Baylin	Nat Rev Genet	2002	12042769	No
943	3368	1684.0	106.63	53.3	Distributed hierarchical processing in the primate cerebral cortex.	D J Felleman, D C Van Essen	Cereb Cortex	1991	1822724	No
944	1683	1683.0	46.46	46.5	A theory of cortical responses.	Karl Friston	Philos Trans R Soc Lond B Biol Sci	2005	15937014	No
945	5047	1682.3	127.88	42.6	A new statistical method for haplotype reconstruction from population data.	M Stephens, N J Smith, P Donnelly	Am J Hum Genet	2001	11254454	Yes
946	1682	1682.0	44.03	44.0	DAMPs, PAMPs and alarmins: all we need to know about danger.	Marco E Bianchi	J Leukoc Biol	2007	17032697	No
947	1682	1682.0	77.57	77.6	The Resonating Valence Bond State in La2CuO4 and Superconductivity.	P W Anderson	Science	1987	17818979	Yes
948	3361	1680.5	0.0	0.0	Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years.	J V Durnin, J Womersley	Br J Nutr	1974	4843734	Yes
949	1680	1680.0	35.77	35.8	Signalling pathways of the TNF superfamily: a double-edged sword.	Bharat B Aggarwal	Nat Rev Immunol	2003	12949498	No
950	1678	1678.0	50.2	50.2	The physiology of glucagon-like peptide 1.	Jens Juul Holst	Physiol Rev	2007	17928588	No
951	3353	1676.5	94.03	47.0	The endophenotype concept in psychiatry: etymology and strategic intentions.	Irving I Gottesman, Todd D Gould	Am J Psychiatry	2003	12668349	No
952	1676	1676.0	83.95	84.0	A systematic method for clinical description and classification of personality variants. A proposal.	C R Cloninger	Arch Gen Psychiatry	1987	3579504	Yes
953	3351	1675.5	98.14	49.1	Regulation of the mevalonate pathway.	J L Goldstein, M S Brown	Nature	1990	1967820	No
954	5023	1674.3	172.51	57.5	Arlequin (version 3.0): an integrated software package for population genetics data analysis.	Laurent Excoffier, Guillaume Laval, Stefan Schneider	Evol Bioinform Online	2007	19325852	Yes
955	1673	1673.0	59.35	59.4	Calbindin D-28k and parvalbumin in the rat nervous system.	M R Celio	Neuroscience	1990	2199841	Yes
956	3345	1672.5	98.71	49.4	Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.	M Nei, T Gojobori	Mol Biol Evol	1986	3444411	Yes
957	1672	1672.0	34.81	34.8	Systems biology: a brief overview.	Hiroaki Kitano	Science	2002	11872829	No
958	1671	1671.0	39.06	39.1	TRP channels as cellular sensors.	David E Clapham	Nature	2003	14654832	No
959	5012	1670.7	147.68	49.2	GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants.	R A Jefferson, T A Kavanagh, M W Bevan	EMBO J	1987	3327686	Yes
960	3335	1667.5	0.0	0.0	A diagnostic interview: the schedule for affective disorders and schizophrenia.	J Endicott, R L Spitzer	Arch Gen Psychiatry	1978	678037	Yes
961	3334	1667.0	69.92	35.0	Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.	M Karin, Y Ben-Neriah	Annu Rev Immunol	2000	10837071	No
962	1663	1663.0	46.25	46.2	The structure and regulation of protein phosphatases.	P Cohen	Annu Rev Biochem	1989	2549856	No
963	1662	1662.0	0.0	0.0	Transplacental carcinogenesis by stilbestrol.	J Folkman	N Engl J Med	1971	5556579	Yes
964	1661	1661.0	39.68	39.7	The immunopathogenesis of sepsis.	Jonathan Cohen	Nature	2002	12490963	No
965	1661	1661.0	45.51	45.5	Follicular helper CD4 T cells (TFH).	Shane Crotty	Annu Rev Immunol	2011	21314428	No
966	1659	1659.0	34.48	34.5	In situ hybridization: an improved whole-mount method for Xenopus embryos.	R M Harland	Methods Cell Biol	1991	1811161	Yes
967	6631	1657.8	143.55	35.9	WebLogo: a sequence logo generator.	Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E Brenner	Genome Res	2004	15173120	Yes
968	1657	1657.0	89.2	89.2	The quality of care. How can it be assessed?	A Donabedian	JAMA	1988	3045356	No
969	1657	1657.0	74.83	74.8	Determination of glutathione and glutathione disulfide in biological samples.	M E Anderson	Methods Enzymol	1985	4088074	Yes
970	1655	1655.0	36.43	36.4	Protein modules and signalling networks.	T Pawson	Nature	1995	7531822	No
971	1655	1655.0	47.45	47.5	The extracellular matrix: not just pretty fibrils.	Richard O Hynes	Science	2009	19965464	No
972	18187	1653.4	395.96	36.0	Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.	Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P Mesirov	Proc Natl Acad Sci U S A	2005	16199517	Yes
973	1652	1652.0	82.87	82.9	Predicting basal metabolic rate, new standards and review of previous work.	W N Schofield	Hum Nutr Clin Nutr	1985	4044297	Yes
974	1652	1652.0	64.22	64.2	Social cognitive theory: an agentic perspective.	A Bandura	Annu Rev Psychol	2001	11148297	Yes
975	3303	1651.5	151.26	75.6	The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories.	P F Lovibond, S H Lovibond	Behav Res Ther	1995	7726811	Yes
976	4954	1651.3	99.21	33.1	Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.	Jason D Fontenot, Marc A Gavin, Alexander Y Rudensky	Nat Immunol	2003	12612578	Yes
977	1651	1651.0	0.0	0.0	Efficient trace-labelling of proteins with iodine.	A S McFARLANE	Nature	1958	13566175	Yes
978	1650	1650.0	32.38	32.4	Signaling--2000 and beyond.	T Hunter	Cell	2000	10647936	No
979	3299	1649.5	108.56	54.3	A receptor-mediated pathway for cholesterol homeostasis.	M S Brown, J L Goldstein	Science	1986	3513311	No
980	3299	1649.5	107.59	53.8	A simple and very efficient method for generating cDNA libraries.	U Gubler, B J Hoffman	Gene	1983	6198242	Yes
981	3297	1648.5	0.0	0.0	On the size of the active site in proteases. I. Papain.	I Schechter, A Berger	Biochem Biophys Res Commun	1967	6035483	Yes
982	1647	1647.0	0.0	0.0	Analysis of bacteriophage T7 early RNAs and proteins on slab gels.	F W Studier	J Mol Biol	1973	4760132	Yes
983	1647	1647.0	34.93	34.9	Antiviral actions of interferons.	C E Samuel	Clin Microbiol Rev	2001	11585785	No
984	1644	1644.0	47.27	47.3	Mechanisms and genes of cellular suicide.	H Steller	Science	1995	7878463	No
985	1644	1644.0	38.44	38.4	Mechanisms of intracellular protein transport.	J E Rothman	Nature	1994	7969419	No
986	3287	1643.5	88.74	44.4	Measuring the thickness of the human cerebral cortex from magnetic resonance images.	B Fischl, A M Dale	Proc Natl Acad Sci U S A	2000	10984517	Yes
987	1643	1643.0	0.0	0.0	A GENERALIZED WILCOXON TEST FOR COMPARING ARBITRARILY SINGLY-CENSORED SAMPLES.	E A GEHAN	Biometrika	1965	14341275	Yes
988	1643	1643.0	45.22	45.2	Interfaces and the driving force of hydrophobic assembly.	David Chandler	Nature	2005	16193038	No
989	1642	1642.0	35.99	36.0	Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls.	R J Kaufman	Genes Dev	1999	10346810	No
990	4920	1640.0	185.54	61.8	Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data.	L Excoffier, P E Smouse, J M Quattro	Genetics	1992	1644282	Yes
991	1640	1640.0	87.96	88.0	The Children's Depression, Inventory (CDI).	M Kovacs	Psychopharmacol Bull	1985	4089116	Yes
992	3279	1639.5	93.21	46.6	Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.	P J Barnes, M Karin	N Engl J Med	1997	9091804	No
993	1639	1639.0	39.52	39.5	Neutrophils and immunity: challenges and opportunities.	Carl Nathan	Nat Rev Immunol	2006	16498448	No
994	3276	1638.0	91.98	46.0	Leptin and the regulation of body weight in mammals.	J M Friedman, J L Halaas	Nature	1998	9796811	No
995	3275	1637.5	82.98	41.5	The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.	A J Ridley, A Hall	Cell	1992	1643657	Yes
996	3275	1637.5	0.0	0.0	High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.	M N Berry, D S Friend	J Cell Biol	1969	4900611	Yes
997	1637	1637.0	45.36	45.4	Protein kinase C and lipid signaling for sustained cellular responses.	Y Nishizuka	FASEB J	1995	7737456	No
998	1637	1637.0	36.71	36.7	Role of angiogenesis in tumor growth and metastasis.	Judah Folkman	Semin Oncol	2002	12516034	No
999	1637	1637.0	0.0	0.0	Analysis of tissue and arterial blood temperatures in the resting human forearm.	H H PENNES	J Appl Physiol	1948	18887578	Yes
1000	3274	1637.0	155.46	77.7	Multiwfn: a multifunctional wavefunction analyzer.	Tian Lu, Feiwu Chen	J Comput Chem	2012	22162017	Yes
1001	1636	1636.0	44.66	44.7	Calcium signaling.	D E Clapham	Cell	1995	7834745	No
1002	4908	1636.0	152.69	50.9	Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors.	F E Harrell, K L Lee, D B Mark	Stat Med	1996	8668867	No
1003	3270	1635.0	0.0	0.0	Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.	P J Fraker, J C Speck	Biochem Biophys Res Commun	1978	637870	Yes
1004	1634	1634.0	40.65	40.6	Cellular mechanisms of insulin resistance.	G I Shulman	J Clin Invest	2000	10903330	No
1005	1632	1632.0	50.24	50.2	The molecular pathology of Alzheimer's disease.	D J Selkoe	Neuron	1991	1673054	No
1006	1632	1632.0	0.0	0.0	Diffusion-in-gel methods for immunological analysis.	O OUCHTERLONY	Prog Allergy	1958	13578996	Yes
1007	1632	1632.0	42.73	42.7	The global health burden of infection-associated cancers in the year 2002.	Donald Maxwell Parkin	Int J Cancer	2006	16404738	Yes
1008	1631	1631.0	46.84	46.8	Flow-mediated endothelial mechanotransduction.	P F Davies	Physiol Rev	1995	7624393	No
1009	3262	1631.0	95.54	47.8	Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium.	Kresse, Hafner	Phys Rev B Condens Matter	1994	10010505	Yes
1010	1631	1631.0	63.95	64.0	Plant products as antimicrobial agents.	M M Cowan	Clin Microbiol Rev	1999	10515903	No
1011	1629	1629.0	32.96	33.0	Notch signalling: a simple pathway becomes complex.	Sarah J Bray	Nat Rev Mol Cell Biol	2006	16921404	No
1012	1628	1628.0	37.31	37.3	Developmental regulation of the growth plate.	Henry M Kronenberg	Nature	2003	12748651	No
1013	3255	1627.5	64.3	32.1	Rho GTPases in cell biology.	Sandrine Etienne-Manneville, Alan Hall	Nature	2002	12478284	No
1014	1627	1627.0	0.0	0.0	The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.	R R PORTER	Biochem J	1959	14434282	Yes
1015	1626	1626.0	41.45	41.5	Targeting PI3K signalling in cancer: opportunities, challenges and limitations.	Jeffrey A Engelman	Nat Rev Cancer	2009	19629070	No
1016	1625	1625.0	34.69	34.7	DNA topoisomerases: structure, function, and mechanism.	J J Champoux	Annu Rev Biochem	2001	11395412	No
1017	3249	1624.5	0.0	0.0	Judgment under Uncertainty: Heuristics and Biases.	A Tversky, D Kahneman	Science	1974	17835457	Yes
1018	1624	1624.0	56.4	56.4	Inhibited spontaneous emission in solid-state physics and electronics.	Yablonovitch	Phys Rev Lett	1987	10034639	Yes
1019	1621	1621.0	81.16	81.2	Role of Streptococcus mutans in human dental decay.	W J Loesche	Microbiol Rev	1986	3540569	No
1020	3241	1620.5	117.08	58.5	Efficient pseudopotentials for plane-wave calculations.	Troullier, Martins	Phys Rev B Condens Matter	1991	9997467	Yes
1021	3239	1619.5	0.0	0.0	Loss of recent memory after bilateral hippocampal lesions.	W B SCOVILLE, B MILNER	J Neurol Neurosurg Psychiatry	1957	13406589	Yes
1022	4857	1619.0	196.51	65.5	featureCounts: an efficient general purpose program for assigning sequence reads to genomic features.	Yang Liao, Gordon K Smyth, Wei Shi	Bioinformatics	2014	24227677	Yes
1023	3226	1613.0	80.56	40.3	Base-calling of automated sequencer traces using phred. II. Error probabilities.	B Ewing, P Green	Genome Res	1998	9521922	Yes
1024	4838	1612.7	241.59	80.5	HISAT: a fast spliced aligner with low memory requirements.	Daehwan Kim, Ben Langmead, Steven L Salzberg	Nat Methods	2015	25751142	Yes
1025	1610	1610.0	52.43	52.4	Patterns of amino acids near signal-sequence cleavage sites.	G von Heijne	Eur J Biochem	1983	6852022	Yes
1026	1610	1610.0	86.91	86.9	A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992.	E L Bradley	Arch Surg	1993	8489394	No
1027	3220	1610.0	90.73	45.4	Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering	Nie, Emory	Science	1997	9027306	Yes
1028	1610	1610.0	65.05	65.0	Keratoconus.	Y S Rabinowitz	Surv Ophthalmol	1998	9493273	No
1029	1610	1610.0	64.45	64.5	Health consequences of intimate partner violence.	Jacquelyn C Campbell	Lancet	2002	11965295	No
1030	1609	1609.0	29.98	30.0	The regulation of E2F by pRB-family proteins.	N Dyson	Genes Dev	1998	9694791	No
1031	1608	1608.0	64.64	64.6	The use of a plus-maze to measure anxiety in the mouse.	R G Lister	Psychopharmacology (Berl)	1987	3110839	Yes
1032	1607	1607.0	35.8	35.8	The expanding role of mitochondria in apoptosis.	X Wang	Genes Dev	2001	11711427	No
1033	1606	1606.0	79.77	79.8	Approximate entropy as a measure of system complexity.	S M Pincus	Proc Natl Acad Sci U S A	1991	11607165	Yes
1034	4801	1600.3	117.53	39.2	Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR.	Michael W Pfaffl, Graham W Horgan, Leo Dempfle	Nucleic Acids Res	2002	11972351	Yes
1035	3200	1600.0	92.01	46.0	Protein structure prediction on the Web: a case study using the Phyre server.	Lawrence A Kelley, Michael J E Sternberg	Nat Protoc	2009	19247286	Yes
1036	1599	1599.0	36.86	36.9	Thrombin signalling and protease-activated receptors.	S R Coughlin	Nature	2000	11001069	No
1037	11191	1598.7	281.49	40.2	Induction of pluripotent stem cells from adult human fibroblasts by defined factors.	Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka	Cell	2007	18035408	Yes
1038	1598	1598.0	33.43	33.4	MicroRNA biogenesis: coordinated cropping and dicing.	V Narry Kim	Nat Rev Mol Cell Biol	2005	15852042	No
1039	1597	1597.0	0.0	0.0	The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis.	U E Loening	Biochem J	1967	5339944	Yes
1040	1597	1597.0	43.42	43.4	Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver.	Scott L Friedman	Physiol Rev	2008	18195085	No
1041	3194	1597.0	131.18	65.6	The biofilm matrix.	Hans-Curt Flemming, Jost Wingender	Nat Rev Microbiol	2010	20676145	No
1042	1595	1595.0	44.05	44.0	Cancer chemoprevention with dietary phytochemicals.	Young-Joon Surh	Nat Rev Cancer	2003	14570043	No
1043	6378	1594.5	285.48	71.4	The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire.	T F Heatherton, L T Kozlowski, R C Frecker, K O Fagerström	Br J Addict	1991	1932883	Yes
1044	1594	1594.0	39.52	39.5	The distribution of secondary growths in cancer of the breast. 1889.	S Paget	Cancer Metastasis Rev	1989	2673568	No
1045	3184	1592.0	0.0	0.0	The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin.	J A Spudich, S Watt	J Biol Chem	1971	4254541	Yes
1046	1590	1590.0	0.0	0.0	The catecholamine hypothesis of affective disorders: a review of supporting evidence.	J J Schildkraut	Am J Psychiatry	1965	5319766	No
1047	1590	1590.0	75.54	75.5	Role of nrf2 in oxidative stress and toxicity.	Qiang Ma	Annu Rev Pharmacol Toxicol	2013	23294312	No
1048	1589	1589.0	43.71	43.7	The mitogen-activated protein kinase signal transduction pathway.	R J Davis	J Biol Chem	1993	8325833	No
1049	6353	1588.2	169.12	42.3	Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels.	A Shevchenko, M Wilm, O Vorm, M Mann	Anal Chem	1996	8779443	Yes
1050	1588	1588.0	45.17	45.2	Breast cancer and hormone-replacement therapy in the Million Women Study.	Valerie Beral	Lancet	2003	12927427	Yes
1051	1585	1585.0	80.36	80.4	Calmodulin plays a pivotal role in cellular regulation.	W Y Cheung	Science	1980	6243188	No
1052	4754	1584.7	185.71	61.9	Parallel organization of functionally segregated circuits linking basal ganglia and cortex.	G E Alexander, M R DeLong, P L Strick	Annu Rev Neurosci	1986	3085570	No
1053	3169	1584.5	181.89	90.9	Stages and processes of self-change of smoking: toward an integrative model of change.	J O Prochaska, C C DiClemente	J Consult Clin Psychol	1983	6863699	Yes
1054	1584	1584.0	0.0	0.0	Evaluating the quality of medical care.	A Donabedian	Milbank Mem Fund Q	1966	5338568	No
1055	1583	1583.0	0.0	0.0	Comparison of the predicted and observed secondary structure of T4 phage lysozyme.	B W Matthews	Biochim Biophys Acta	1975	1180967	Yes
1056	3159	1579.5	82.86	41.4	The future of genetic studies of complex human diseases.	N Risch, K Merikangas	Science	1996	8801636	Yes
1057	3157	1578.5	102.02	51.0	Nonparametric statistical testing of EEG- and MEG-data.	Eric Maris, Robert Oostenveld	J Neurosci Methods	2007	17517438	Yes
1058	3156	1578.0	70.86	35.4	Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia.	C D Nobes, A Hall	Cell	1995	7536630	Yes
1059	6311	1577.8	246.76	61.7	Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.	A J Hughes, S E Daniel, L Kilford, A J Lees	J Neurol Neurosurg Psychiatry	1992	1564476	Yes
1060	1576	1576.0	66.48	66.5	Prooxidant states and tumor promotion.	P A Cerutti	Science	1985	2981433	No
1061	3152	1576.0	94.04	47.0	Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.	G G Glenner, C W Wong	Biochem Biophys Res Commun	1984	6375662	Yes
1062	1575	1575.0	37.29	37.3	A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics.	J SantaLucia	Proc Natl Acad Sci U S A	1998	9465037	Yes
1063	1574	1574.0	48.17	48.2	Hepatitis B virus infection.	W M Lee	N Engl J Med	1997	9392700	No
1064	1574	1574.0	67.53	67.5	Doxil®--the first FDA-approved nano-drug: lessons learned.	Yechezkel Barenholz	J Control Release	2012	22484195	No
1065	3147	1573.5	72.45	36.2	Cell death: critical control points.	Nika N Danial, Stanley J Korsmeyer	Cell	2004	14744432	No
1066	1573	1573.0	48.82	48.8	Bcl-2 and the regulation of programmed cell death.	J C Reed	J Cell Biol	1994	8294493	No
1067	3146	1573.0	109.0	54.5	Wnt/β-catenin signaling and disease.	Hans Clevers, Roel Nusse	Cell	2012	22682243	No
1068	1571	1571.0	48.3	48.3	Intestinal mucosal barrier function in health and disease.	Jerrold R Turner	Nat Rev Immunol	2009	19855405	No
1069	1569	1569.0	39.54	39.5	Integrating cell-signalling pathways with NF-kappaB and IKK function.	Neil D Perkins	Nat Rev Mol Cell Biol	2007	17183360	No
1070	1569	1569.0	82.13	82.1	Microplastics in the marine environment.	Anthony L Andrady	Mar Pollut Bull	2011	21742351	No
1071	4706	1568.7	188.26	62.8	AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet.	P G Reeves, F H Nielsen, G C Fahey	J Nutr	1993	8229312	No
1072	1568	1568.0	61.63	61.6	Epidemiological features of chronic low-back pain.	G B Andersson	Lancet	1999	10470716	No
1073	7837	1567.4	206.4	41.3	Mapping and quantifying mammalian transcriptomes by RNA-Seq.	Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara Wold	Nat Methods	2008	18516045	Yes
1074	1567	1567.0	0.0	0.0	Inositol phospholipids and cell surface receptor function.	R H Michell	Biochim Biophys Acta	1975	164246	No
1075	6265	1566.2	302.68	75.7	A simple technique for quantitation of low levels of DNA damage in individual cells.	N P Singh, M T McCoy, R R Tice, E L Schneider	Exp Cell Res	1988	3345800	Yes
1076	1565	1565.0	42.53	42.5	Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity.	G Trinchieri	Annu Rev Immunol	1995	7612223	No
1077	1565	1565.0	36.36	36.4	Exploring complex networks.	S H Strogatz	Nature	2001	11258382	No
1078	3129	1564.5	72.49	36.2	Lessons from hereditary colorectal cancer.	K W Kinzler, B Vogelstein	Cell	1996	8861899	No
1079	3126	1563.0	99.49	49.7	The heat-shock proteins.	S Lindquist, E A Craig	Annu Rev Genet	1988	2853609	No
1080	1562	1562.0	56.75	56.8	Protein oxidation and aging.	E R Stadtman	Science	1992	1355616	No
1081	4684	1561.3	180.64	60.2	Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire.	R L Spitzer, K Kroenke, J B Williams	JAMA	1999	10568646	Yes
1082	1561	1561.0	76.83	76.8	Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases.	B N Ames	Science	1983	6351251	No
1083	1560	1560.0	107.94	107.9	Determination and quantification of content validity.	M R Lynn	Nurs Res	1986	3640358	Yes
1084	1560	1560.0	44.59	44.6	Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials.	Fiona Turnbull	Lancet	2003	14615107	Yes
1085	6239	1559.8	239.98	60.0	A brief measure for assessing generalized anxiety disorder: the GAD-7.	Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd Löwe	Arch Intern Med	2006	16717171	Yes
1086	3118	1559.0	72.11	36.1	Monocyte and macrophage heterogeneity.	Siamon Gordon, Philip R Taylor	Nat Rev Immunol	2005	16322748	No
1087	6234	1558.5	172.35	43.1	Epithelial-mesenchymal transitions in development and disease.	Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela Nieto	Cell	2009	19945376	No
1088	3116	1558.0	170.95	85.5	The Health Belief Model: a decade later.	N K Janz, M H Becker	Health Educ Q	1984	6392204	No
1089	3114	1557.0	0.0	0.0	Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method.	R B Devereux, N Reichek	Circulation	1977	138494	Yes
1090	4670	1556.7	160.48	53.5	FastTree 2--approximately maximum-likelihood trees for large alignments.	Morgan N Price, Paramvir S Dehal, Adam P Arkin	PLoS One	2010	20224823	Yes
1091	1556	1556.0	35.83	35.8	Structure and regulation of voltage-gated Ca2+ channels.	W A Catterall	Annu Rev Cell Dev Biol	2000	11031246	No
1092	4664	1554.7	177.26	59.1	Cell death: the significance of apoptosis.	A H Wyllie, J F Kerr, A R Currie	Int Rev Cytol	1980	7014501	No
1093	1554	1554.0	49.46	49.5	Biofilms: microbial life on surfaces.	Rodney M Donlan	Emerg Infect Dis	2002	12194761	No
1094	1553	1553.0	0.0	0.0	Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu.	M J Casadaban	J Mol Biol	1976	781293	Yes
1095	1552	1552.0	40.2	40.2	Global cancer statistics in the year 2000.	D M Parkin	Lancet Oncol	2001	11905707	No
1096	3101	1550.5	0.0	0.0	Acetylornithinase of Escherichia coli: partial purification and some properties.	H J VOGEL, D M BONNER	J Biol Chem	1956	13278318	Yes
1097	3099	1549.5	93.42	46.7	The inflammasomes.	Kate Schroder, Jurg Tschopp	Cell	2010	20303873	No
1098	4647	1549.0	1678.07	559.4	Cancer statistics, 2020.	Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal	CA Cancer J Clin	2020	31912902	Yes
1099	1545	1545.0	106.7	106.7	The assessment of clinical skills/competence/performance.	G E Miller	Acad Med	1990	2400509	Yes
1100	1545	1545.0	34.32	34.3	Molecular regulation of vessel maturation.	Rakesh K Jain	Nat Med	2003	12778167	No
1101	3088	1544.0	97.33	48.7	Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction.	P Liang, A B Pardee	Science	1992	1354393	Yes
1102	1544	1544.0	0.0	0.0	Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?	J V NEEL	Am J Hum Genet	1962	13937884	Yes
1103	1543	1543.0	0.0	0.0	The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides.	G S Manning	Q Rev Biophys	1978	353876	No
1104	1542	1542.0	0.0	0.0	Notes on sugar determination.	M SMOGYI	J Biol Chem	1952	14938350	Yes
1105	1541	1541.0	59.07	59.1	ATP-regulated K+ channels in cardiac muscle.	A Noma	Nature	1983	6310409	Yes
1106	1540	1540.0	0.0	0.0	Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults.	O SMITHIES	Biochem J	1955	13276348	Yes
1107	1540	1540.0	46.96	47.0	MYC on the path to cancer.	Chi V Dang	Cell	2012	22464321	No
1108	6159	1539.8	265.46	66.4	Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses.	Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg Lang	Behav Res Methods	2009	19897823	Yes
1109	3079	1539.5	164.68	82.3	The MOS social support survey.	C D Sherbourne, A L Stewart	Soc Sci Med	1991	2035047	Yes
1110	3074	1537.0	0.0	0.0	Some quantitative uses of drug antagonists.	O ARUNLAKSHANA, H O SCHILD	Br J Pharmacol Chemother	1959	13651579	Yes
1111	1537	1537.0	41.86	41.9	The genetics of ageing.	Cynthia J Kenyon	Nature	2010	20336132	No
1112	1534	1534.0	58.93	58.9	Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.	R A DeFronzo	Diabetes	1988	3289989	No
1113	1534	1534.0	43.22	43.2	Using circular dichroism spectra to estimate protein secondary structure.	Norma J Greenfield	Nat Protoc	2006	17406547	Yes
1114	3067	1533.5	140.22	70.1	miRBase: annotating high confidence microRNAs using deep sequencing data.	Ana Kozomara, Sam Griffiths-Jones	Nucleic Acids Res	2014	24275495	Yes
1115	1533	1533.0	51.37	51.4	PsychoPy--Psychophysics software in Python.	Jonathan W Peirce	J Neurosci Methods	2007	17254636	Yes
1116	4596	1532.0	0.0	0.0	Glucose clamp technique: a method for quantifying insulin secretion and resistance.	R A DeFronzo, J D Tobin, R Andres	Am J Physiol	1979	382871	Yes
1117	1532	1532.0	52.21	52.2	Social determinants of health inequalities.	Michael Marmot	Lancet	2005	15781105	Yes
1118	1531	1531.0	53.76	53.8	Excitotoxic cell death.	D W Choi	J Neurobiol	1992	1361523	No
1119	1531	1531.0	32.3	32.3	DNA methylation and human disease.	Keith D Robertson	Nat Rev Genet	2005	16136652	No
1120	3061	1530.5	0.0	0.0	Mathematical model for studying genetic variation in terms of restriction endonucleases.	M Nei, W H Li	Proc Natl Acad Sci U S A	1979	291943	Yes
1121	3061	1530.5	93.48	46.7	Assembly of asparagine-linked oligosaccharides.	R Kornfeld, S Kornfeld	Annu Rev Biochem	1985	3896128	No
1122	1530	1530.0	43.67	43.7	Drug-like properties and the causes of poor solubility and poor permeability.	C A Lipinski	J Pharmacol Toxicol Methods	2000	11274893	No
1123	6114	1528.5	268.3	67.1	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	J Clin Epidemiol	2009	19631508	No
1124	1528	1528.0	41.24	41.2	The dawning era of polymer therapeutics.	Ruth Duncan	Nat Rev Drug Discov	2003	12750738	No
1125	1528	1528.0	32.62	32.6	The synaptic vesicle cycle.	Thomas C Sudhof	Annu Rev Neurosci	2004	15217342	No
1126	3054	1527.0	0.0	0.0	A SIMPLIFIED LEAD CITRATE STAIN FOR USE IN ELECTRON MICROSCOPY.	J H VENABLE, R COGGESHALL	J Cell Biol	1965	14287192	Yes
1127	3051	1525.5	79.02	39.5	CAP3: A DNA sequence assembly program.	X Huang, A Madan	Genome Res	1999	10508846	Yes
1128	1525	1525.0	57.08	57.1	An overview of brominated flame retardants in the environment.	Cynthia A de Wit	Chemosphere	2002	11999784	No
1129	1524	1524.0	37.96	38.0	Fabrication of novel biomaterials through molecular self-assembly.	Shuguang Zhang	Nat Biotechnol	2003	14520402	No
1130	1523	1523.0	53.48	53.5	Global epidemiology of oral and oropharyngeal cancer.	Saman Warnakulasuriya	Oral Oncol	2009	18804401	No
1131	4568	1522.7	132.42	44.1	Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.	G S Hotamisligil, N S Shargill, B M Spiegelman	Science	1993	7678183	Yes
1132	3045	1522.5	86.87	43.4	Building better batteries.	M Armand, J-M Tarascon	Nature	2008	18256660	No
1133	1522	1522.0	39.49	39.5	Metabolomics--the link between genotypes and phenotypes.	Oliver Fiehn	Plant Mol Biol	2002	11860207	No
1134	1522	1522.0	62.01	62.0	Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope.	Lutz Ackermann	Chem Rev	2011	21391562	Yes
1135	1520	1520.0	50.45	50.5	Introduction and General Overview of Cyclodextrin Chemistry.	József Szejtli	Chem Rev	1998	11848947	Yes
1136	1520	1520.0	58.93	58.9	Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium.	Sergio Pecorelli	Int J Gynaecol Obstet	2009	19367689	No
1137	3038	1519.0	169.78	84.9	The Brief Symptom Inventory: an introductory report.	L R Derogatis, N Melisaratos	Psychol Med	1983	6622612	Yes
1138	1519	1519.0	46.83	46.8	The comet assay for DNA damage and repair: principles, applications, and limitations.	Andrew R Collins	Mol Biotechnol	2004	15004294	No
1139	3036	1518.0	0.0	0.0	A complementation analysis of the restriction and modification of DNA in Escherichia coli.	H W Boyer, D Roulland-Dussoix	J Mol Biol	1969	4896022	Yes
1140	3036	1518.0	0.0	0.0	Variations in pattern of pubertal changes in girls.	W A Marshall, J M Tanner	Arch Dis Child	1969	5785179	Yes
1141	1517	1517.0	48.12	48.1	Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic.	Robert E Marx	J Oral Maxillofac Surg	2003	12966493	Yes
1142	1517	1517.0	40.92	40.9	Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures.	D Lavanchy	J Viral Hepat	2004	14996343	No
1143	4548	1516.0	0.0	0.0	Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.	B N Ames, J Mccann, E Yamasaki	Mutat Res	1975	768755	Yes
1144	1516	1516.0	47.01	47.0	Thioredoxin.	A Holmgren	Annu Rev Biochem	1985	3896121	No
1145	1516	1516.0	42.26	42.3	Evolutionary relationship of DNA sequences in finite populations.	F Tajima	Genetics	1983	6628982	Yes
1146	1516	1516.0	0.0	0.0	Dendritic organization in the neurons of the visual and motor cortices of the cat.	D A SHOLL	J Anat	1953	13117757	Yes
1147	3030	1515.0	90.59	45.3	ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT.	B Ravel, M Newville	J Synchrotron Radiat	2005	15968136	Yes
1148	1514	1514.0	85.26	85.3	Detecting alcoholism. The CAGE questionnaire.	J A Ewing	JAMA	1984	6471323	Yes
1149	1514	1514.0	71.37	71.4	Why patients use alternative medicine: results of a national study.	J A Astin	JAMA	1998	9605899	Yes
1150	1513	1513.0	30.36	30.4	CD4+ CD25+ suppressor T cells: more questions than answers.	Ethan M Shevach	Nat Rev Immunol	2002	12093005	No
1151	1513	1513.0	52.75	52.8	Hypoxia-inducible factors in physiology and medicine.	Gregg L Semenza	Cell	2012	22304911	No
1152	3025	1512.5	97.91	49.0	Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.	K D McCarthy, J de Vellis	J Cell Biol	1980	6248568	Yes
1153	1512	1512.0	0.0	0.0	A theory of cerebellar cortex.	D Marr	J Physiol	1969	5784296	Yes
1154	1512	1512.0	51.61	51.6	Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.	A Dunaif	Endocr Rev	1997	9408743	No
1155	1512	1512.0	33.42	33.4	Protein homology detection by HMM-HMM comparison.	Johannes Söding	Bioinformatics	2005	15531603	Yes
1156	1511	1511.0	62.31	62.3	Physiological actions of taurine.	R J Huxtable	Physiol Rev	1992	1731369	No
1157	3021	1510.5	60.61	30.3	SIFT: Predicting amino acid changes that affect protein function.	Pauline C Ng, Steven Henikoff	Nucleic Acids Res	2003	12824425	Yes
1158	1510	1510.0	31.53	31.5	Cancer and the chemokine network.	Fran Balkwill	Nat Rev Cancer	2004	15229479	No
1159	7549	1509.8	229.15	45.8	Global prevalence of diabetes: estimates for the year 2000 and projections for 2030.	Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary King	Diabetes Care	2004	15111519	Yes
1160	1509	1509.0	0.0	0.0	A rating instrument for anxiety disorders.	W W Zung	Psychosomatics	1971	5172928	Yes
1161	1508	1508.0	0.0	0.0	Removal of fatty acids from serum albumin by charcoal treatment.	R F Chen	J Biol Chem	1967	6016603	Yes
1162	1508	1508.0	33.18	33.2	Mechanisms of cancer drug resistance.	Michael M Gottesman	Annu Rev Med	2002	11818492	No
1163	1508	1508.0	34.88	34.9	Excitatory actions of gaba during development: the nature of the nurture.	Yehezkel Ben-Ari	Nat Rev Neurosci	2002	12209121	No
1164	1507	1507.0	49.42	49.4	Infrared spectroscopy of proteins.	Andreas Barth	Biochim Biophys Acta	2007	17692815	No
1165	1505	1505.0	0.0	0.0	SELECTION OF HYBRIDS FROM MATINGS OF FIBROBLASTS IN VITRO AND THEIR PRESUMED RECOMBINANTS.	J W LITTLEFIELD	Science	1964	14168277	Yes
1166	3009	1504.5	84.51	42.3	A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.	G Shaw, R Kamen	Cell	1986	3488815	Yes
1167	1503	1503.0	0.0	0.0	Oxygen-dependent microbial killing by phagocytes (first of two parts).	B M Babior	N Engl J Med	1978	24176	Yes
1168	1503	1503.0	0.0	0.0	Mechanisms of action of transmitters and other substances on smooth muscle.	T B Bolton	Physiol Rev	1979	37533	No
1169	3004	1502.0	73.61	36.8	Parkinson's disease: mechanisms and models.	William Dauer, Serge Przedborski	Neuron	2003	12971891	No
1170	1501	1501.0	0.0	0.0	The plasma lecithins:cholesterol acyltransferase reaction.	J A Glomset	J Lipid Res	1968	4868699	No
1171	1501	1501.0	52.51	52.5	The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation.	G P Chrousos	N Engl J Med	1995	7715646	No
1172	1500	1500.0	36.09	36.1	Recognition of microorganisms and activation of the immune response.	Ruslan Medzhitov	Nature	2007	17943118	No
1173	4498	1499.3	91.91	30.6	Surfing the p53 network.	B Vogelstein, D Lane, A J Levine	Nature	2000	11099028	No
1174	1499	1499.0	0.0	0.0	Chemiosmotic coupling in oxidative and photosynthetic phosphorylation.	P Mitchell	Biol Rev Camb Philos Soc	1966	5329743	No
1175	1499	1499.0	30.06	30.1	Cellular roles of DNA topoisomerases: a molecular perspective.	James C Wang	Nat Rev Mol Cell Biol	2002	12042765	No
1176	2998	1499.0	89.61	44.8	The mirror-neuron system.	Giacomo Rizzolatti, Laila Craighero	Annu Rev Neurosci	2004	15217330	No
1177	1498	1498.0	30.12	30.1	Generating samples under a Wright-Fisher neutral model of genetic variation.	Richard R Hudson	Bioinformatics	2002	11847089	Yes
1178	5991	1497.8	159.53	39.9	Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.	C A Lipinski, F Lombardo, B W Dominy, P J Feeney	Adv Drug Deliv Rev	2001	11259830	No
1179	1497	1497.0	43.05	43.0	An index to quantify an individual's scientific research output.	J E Hirsch	Proc Natl Acad Sci U S A	2005	16275915	Yes
1180	2991	1495.5	76.43	38.2	Liver fibrosis.	Ramón Bataller, David A Brenner	J Clin Invest	2005	15690074	No
1181	5975	1493.8	123.71	30.9	Stem cells, cancer, and cancer stem cells.	T Reya, S J Morrison, M F Clarke, I L Weissman	Nature	2001	11689955	No
1182	2986	1493.0	81.11	40.6	Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.	Christian Haass, Dennis J Selkoe	Nat Rev Mol Cell Biol	2007	17245412	No
1183	2985	1492.5	92.39	46.2	The unfolded protein response: from stress pathway to homeostatic regulation.	Peter Walter, David Ron	Science	2011	22116877	No
1184	1491	1491.0	0.0	0.0	Presidential Address-1976. Social support as a moderator of life stress.	S Cobb	Psychosom Med	1976	981490	Yes
1185	2977	1488.5	95.18	47.6	Biofilms: survival mechanisms of clinically relevant microorganisms.	Rodney M Donlan, J William Costerton	Clin Microbiol Rev	2002	11932229	No
1186	4463	1487.7	99.5	33.2	A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays.	Zhang, Chung, Oldenburg	J Biomol Screen	1999	10838414	Yes
1187	1487	1487.0	44.28	44.3	Signal sequences. The limits of variation.	G von Heijne	J Mol Biol	1985	4032478	Yes
1188	2973	1486.5	75.12	37.6	Identification of common molecular subsequences.	T F Smith, M S Waterman	J Mol Biol	1981	7265238	Yes
1189	2972	1486.0	0.0	0.0	A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase.	R F BEERS, I W SIZER	J Biol Chem	1952	14938361	Yes
1190	1484	1484.0	32.56	32.6	The effect of infections on susceptibility to autoimmune and allergic diseases.	Jean-Francois Bach	N Engl J Med	2002	12239261	No
1191	1484	1484.0	44.34	44.3	THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons.	Kozi Asada	Annu Rev Plant Physiol Plant Mol Biol	1999	15012221	Yes
1192	2967	1483.5	120.65	60.3	Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.	G Di Chiara, A Imperato	Proc Natl Acad Sci U S A	1988	2899326	Yes
1193	2967	1483.5	76.1	38.0	Neuronal oscillations in cortical networks.	György Buzsáki, Andreas Draguhn	Science	2004	15218136	No
1194	1483	1483.0	0.0	0.0	A classification of hand preference by association analysis.	M Annett	Br J Psychol	1970	5457503	Yes
1195	1482	1482.0	0.0	0.0	Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry.	M Wong-Riley	Brain Res	1979	223730	Yes
1196	1482	1482.0	50.51	50.5	Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance.	F Rousset	Genetics	1997	9093870	Yes
1197	5921	1480.2	163.42	40.9	Cancer-related inflammation.	Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill	Nature	2008	18650914	No
1198	1479	1479.0	45.07	45.1	Chlorpromazine equivalent doses for the newer atypical antipsychotics.	Scott W Woods	J Clin Psychiatry	2003	12823080	No
1199	10340	1477.1	453.5	64.8	Assessing the quality of reports of randomized clinical trials: is blinding necessary?	A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuay	Control Clin Trials	1996	8721797	Yes
1200	1477	1477.0	0.0	0.0	Positional information and the spatial pattern of cellular differentiation.	L Wolpert	J Theor Biol	1969	4390734	Yes
1201	1477	1477.0	66.66	66.7	Heavy metal intensification of DAB-based HRP reaction product.	J C Adams	J Histochem Cytochem	1981	7252134	Yes
1202	1476	1476.0	35.58	35.6	AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.	D Grahame Hardie	Nat Rev Mol Cell Biol	2007	17712357	No
1203	1475	1475.0	46.91	46.9	Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution.	H LeVine	Protein Sci	1993	8453378	Yes
1204	2948	1474.0	0.0	0.0	An efficient mRNA-dependent translation system from reticulocyte lysates.	H R Pelham, R J Jackson	Eur J Biochem	1976	823012	Yes
1205	2947	1473.5	0.0	0.0	Genetic regulatory mechanisms in the synthesis of proteins.	F JACOB, J MONOD	J Mol Biol	1961	13718526	Yes
1206	1473	1473.0	35.59	35.6	Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury.	S L Friedman	J Biol Chem	2000	10644669	No
1207	1472	1472.0	54.27	54.3	Grounded cognition.	Lawrence W Barsalou	Annu Rev Psychol	2008	17705682	No
1208	1471	1471.0	38.16	38.2	The synaptic vesicle cycle: a cascade of protein-protein interactions.	T C Südhof	Nature	1995	7791897	No
1209	1470	1470.0	43.58	43.6	What is cognitive reserve? Theory and research application of the reserve concept.	Yaakov Stern	J Int Neuropsychol Soc	2002	11939702	No
1210	1470	1470.0	38.22	38.2	Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems.	S A Bustin	J Mol Endocrinol	2002	12200227	No
1211	1470	1470.0	41.52	41.5	Network pharmacology: the next paradigm in drug discovery.	Andrew L Hopkins	Nat Chem Biol	2008	18936753	No
1212	1470	1470.0	36.88	36.9	The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.	Michael R Lieber	Annu Rev Biochem	2010	20192759	No
1213	1469	1469.0	86.64	86.6	Performance-oriented assessment of mobility problems in elderly patients.	M E Tinetti	J Am Geriatr Soc	1986	3944402	Yes
1214	1469	1469.0	47.76	47.8	Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis.	J Folkman	N Engl J Med	1995	7491141	No
1215	5875	1468.8	235.35	58.8	SignalP 4.0: discriminating signal peptides from transmembrane regions.	Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik Nielsen	Nat Methods	2011	21959131	Yes
1216	1464	1464.0	56.54	56.5	Archaea in coastal marine environments.	E F DeLong	Proc Natl Acad Sci U S A	1992	1608980	Yes
1217	1464	1464.0	56.56	56.6	Diagnosis of Alzheimer's disease.	Z S Khachaturian	Arch Neurol	1985	2864910	Yes
1218	2927	1463.5	68.0	34.0	Insulin signalling and the regulation of glucose and lipid metabolism.	A R Saltiel, C R Kahn	Nature	2001	11742412	Yes
1219	1462	1462.0	51.98	52.0	A measure of population subdivision based on microsatellite allele frequencies.	M Slatkin	Genetics	1995	7705646	Yes
1220	1462	1462.0	38.36	38.4	Type III protein secretion systems in bacterial pathogens of animals and plants.	C J Hueck	Microbiol Mol Biol Rev	1998	9618447	No
1221	2923	1461.5	68.12	34.1	Integrin signaling.	F G Giancotti, E Ruoslahti	Science	1999	10446041	No
1222	1460	1460.0	38.22	38.2	G1 events and regulation of cell proliferation.	A B Pardee	Science	1989	2683075	No
1223	1459	1459.0	39.43	39.4	Episodic memory: from mind to brain.	Endel Tulving	Annu Rev Psychol	2002	11752477	Yes
1224	2917	1458.5	108.17	54.1	Understanding interobserver agreement: the kappa statistic.	Anthony J Viera, Joanne M Garrett	Fam Med	2005	15883903	Yes
1225	2915	1457.5	79.46	39.7	A scaling normalization method for differential expression analysis of RNA-seq data.	Mark D Robinson, Alicia Oshlack	Genome Biol	2010	20196867	Yes
1226	1455	1455.0	48.52	48.5	Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996.	E M Wassermann	Electroencephalogr Clin Neurophysiol	1998	9474057	No
1227	1454	1454.0	0.0	0.0	Purinergic nerves.	G Burnstock	Pharmacol Rev	1972	4404211	No
1228	1453	1453.0	38.62	38.6	Angiogenesis: an organizing principle for drug discovery?	Judah Folkman	Nat Rev Drug Discov	2007	17396134	No
1229	2904	1452.0	68.43	34.2	Issues and challenges facing rechargeable lithium batteries.	J M Tarascon, M Armand	Nature	2001	11713543	Yes
1230	2904	1452.0	75.03	37.5	PRODRG: a tool for high-throughput crystallography of protein-ligand complexes.	Alexander W Schüttelkopf, Daan M F van Aalten	Acta Crystallogr D Biol Crystallogr	2004	15272157	Yes
1231	1452	1452.0	0.0	0.0	A study of the adrenotropic receptors.	R P AHLQUIST	Am J Physiol	1948	18882199	Yes
1232	2899	1449.5	75.96	38.0	Amino acid substitution matrices from protein blocks.	S Henikoff, J G Henikoff	Proc Natl Acad Sci U S A	1992	1438297	Yes
1233	1449	1449.0	56.38	56.4	Sick individuals and sick populations.	G Rose	Int J Epidemiol	1985	3872850	Yes
1234	2898	1449.0	120.92	60.5	Oxygen toxicity, oxygen radicals, transition metals and disease.	B Halliwell, J M Gutteridge	Biochem J	1984	6326753	No
1235	1449	1449.0	40.42	40.4	Clinical application of C-reactive protein for cardiovascular disease detection and prevention.	Paul M Ridker	Circulation	2003	12551853	No
1236	2898	1449.0	84.28	42.1	Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes.	Steven E Nissen, Kathy Wolski	N Engl J Med	2007	17517853	Yes
1237	1448	1448.0	41.3	41.3	P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation.	Berk Hess	J Chem Theory Comput	2008	26619985	Yes
1238	1447	1447.0	78.08	78.1	A rating scale for drug-induced akathisia.	T R Barnes	Br J Psychiatry	1989	2574607	Yes
1239	1447	1447.0	37.11	37.1	The retinal pigment epithelium in visual function.	Olaf Strauss	Physiol Rev	2005	15987797	No
1240	2894	1447.0	107.23	53.6	Macrophage plasticity and polarization: in vivo veritas.	Antonio Sica, Alberto Mantovani	J Clin Invest	2012	22378047	No
1241	1446	1446.0	29.33	29.3	Network motifs: theory and experimental approaches.	Uri Alon	Nat Rev Genet	2007	17510665	No
1242	2891	1445.5	77.05	38.5	Origins and Mechanisms of miRNAs and siRNAs.	Richard W Carthew, Erik J Sontheimer	Cell	2009	19239886	No
1243	2890	1445.0	120.12	60.1	ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts.	M Gardes, T D Bruns	Mol Ecol	1993	8180733	Yes
1244	2889	1444.5	83.08	41.5	Receptors for purines and pyrimidines.	V Ralevic, G Burnstock	Pharmacol Rev	1998	9755289	No
1245	1444	1444.0	0.0	0.0	Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate.	J P Chamberlain	Anal Biochem	1979	543547	Yes
1246	1444	1444.0	27.93	27.9	Maximum-likelihood density modification.	T C Terwilliger	Acta Crystallogr D Biol Crystallogr	2000	10944333	Yes
1247	1443	1443.0	43.83	43.8	Interleukin-2: inception, impact, and implications.	K A Smith	Science	1988	3131876	No
1248	1443	1443.0	0.0	0.0	The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers.	D E Atkinson	Biochemistry	1968	4972613	Yes
1249	2885	1442.5	100.92	50.5	Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration.	B J Marshall, J R Warren	Lancet	1984	6145023	Yes
1250	5766	1441.5	145.42	36.4	Transformation of intact yeast cells treated with alkali cations.	H Ito, Y Fukuda, K Murata, A Kimura	J Bacteriol	1983	6336730	Yes
1251	2882	1441.0	94.69	47.3	Insulin-like growth factors and their binding proteins: biological actions.	J I Jones, D R Clemmons	Endocr Rev	1995	7758431	No
1252	1441	1441.0	45.56	45.6	Porous scaffold design for tissue engineering.	Scott J Hollister	Nat Mater	2005	16003400	No
1253	2881	1440.5	72.93	36.5	Protein structure comparison by alignment of distance matrices.	L Holm, C Sander	J Mol Biol	1993	8377180	Yes
1254	1440	1440.0	62.74	62.7	Recognition-by-components: a theory of human image understanding.	Irving Biederman	Psychol Rev	1987	3575582	Yes
1255	1440	1440.0	54.13	54.1	The stress response in fish.	S E Wendelaar Bonga	Physiol Rev	1997	9234959	No
1256	1440	1440.0	33.63	33.6	Neuronal calcium signaling.	M J Berridge	Neuron	1998	9697848	No
1257	2878	1439.0	107.53	53.8	Angiogenic factors.	J Folkman, M Klagsbrun	Science	1987	2432664	No
1258	2878	1439.0	100.24	50.1	New perspectives in cell adhesion: RGD and integrins.	E Ruoslahti, M D Pierschbacher	Science	1987	2821619	No
1259	2878	1439.0	0.0	0.0	Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy.	I W McLean, P K Nakane	J Histochem Cytochem	1974	4374474	Yes
1260	2878	1439.0	69.88	34.9	Raster3D: photorealistic molecular graphics.	E A Merritt, D J Bacon	Methods Enzymol	1997	18488322	Yes
1261	1438	1438.0	36.69	36.7	Chemokines.	B J Rollins	Blood	1997	9242519	No
1262	2874	1437.0	0.0	0.0	Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells.	J G Rheinwald, H Green	Cell	1975	1052771	Yes
1263	2874	1437.0	120.79	60.4	Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine.	M H Zweig, G Campbell	Clin Chem	1993	8472349	No
1264	1437	1437.0	39.45	39.5	Inflammatory bowel disease: etiology and pathogenesis.	C Fiocchi	Gastroenterology	1998	9649475	No
1265	1437	1437.0	48.53	48.5	Flavonoids as antioxidants.	P G Pietta	J Nat Prod	2000	10924197	No
1266	1435	1435.0	50.25	50.2	Classification of inflammatory bowel disease.	J E Lennard-Jones	Scand J Gastroenterol Suppl	1989	2617184	Yes
1267	1434	1434.0	57.44	57.4	Calculation of substrate oxidation rates in vivo from gaseous exchange.	K N Frayn	J Appl Physiol Respir Environ Exerc Physiol	1983	6618956	Yes
1268	11471	1433.9	309.06	38.6	Electric field effect in atomically thin carbon films.	K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A Firsov	Science	2004	15499015	Yes
1269	2867	1433.5	82.06	41.0	Matrix metalloproteinases.	H Nagase, J F Woessner	J Biol Chem	1999	10419448	No
1270	2866	1433.0	0.0	0.0	PREPARATION OF FATTY ACID METHYL ESTERS AND DIMETHYLACETALS FROM LIPIDS WITH BORON FLUORIDE--METHANOL.	W R MORRISON, L M SMITH	J Lipid Res	1964	14221106	Yes
1271	2865	1432.5	67.09	33.5	The epigenomics of cancer.	Peter A Jones, Stephen B Baylin	Cell	2007	17320506	No
1272	4294	1431.3	119.15	39.7	Rapid and efficient site-specific mutagenesis without phenotypic selection.	T A Kunkel, J D Roberts, R A Zakour	Methods Enzymol	1987	3323813	Yes
1273	1431	1431.0	30.27	30.3	Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.	Judith Campisi	Cell	2005	15734683	No
1274	1431	1431.0	56.67	56.7	Guided Search 2.0 A revised model of visual search.	J M Wolfe	Psychon Bull Rev	1994	24203471	Yes
1275	4291	1430.3	123.3	41.1	Median-joining networks for inferring intraspecific phylogenies.	H J Bandelt, P Forster, A Röhl	Mol Biol Evol	1999	10331250	Yes
1276	4291	1430.3	179.3	59.8	Effect of the damping function in dispersion corrected density functional theory.	Stefan Grimme, Stephan Ehrlich, Lars Goerigk	J Comput Chem	2011	21370243	Yes
1277	1430	1430.0	34.02	34.0	Bone morphogenetic proteins: multifunctional regulators of vertebrate development.	B L Hogan	Genes Dev	1996	8682290	No
1278	1430	1430.0	37.47	37.5	Growth of the plant cell wall.	Daniel J Cosgrove	Nat Rev Mol Cell Biol	2005	16261190	No
1279	1429	1429.0	0.0	0.0	Towards a network theory of the immune system.	N K Jerne	Ann Immunol (Paris)	1974	4142565	No
1280	4286	1428.7	114.28	38.1	Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm.	Prateek Kumar, Steven Henikoff, Pauline C Ng	Nat Protoc	2009	19561590	Yes
1281	1428	1428.0	66.95	67.0	Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury.	D R Janero	Free Radic Biol Med	1990	2079232	No
1282	1428	1428.0	43.46	43.5	Molecular dissection of reactive astrogliosis and glial scar formation.	Michael V Sofroniew	Trends Neurosci	2009	19782411	No
1283	1426	1426.0	69.48	69.5	Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review.	H U Wittchen	J Psychiatr Res	1994	8064641	No
1284	2852	1426.0	70.92	35.5	The DNA-damage response in human biology and disease.	Stephen P Jackson, Jiri Bartek	Nature	2009	19847258	No
1285	1425	1425.0	32.01	32.0	Points of control in inflammation.	Carl Nathan	Nature	2002	12490957	No
1286	1425	1425.0	43.2	43.2	Oxidative stress and neurodegeneration: where are we now?	Barry Halliwell	J Neurochem	2006	16805774	No
1287	1425	1425.0	38.29	38.3	Tricine-SDS-PAGE.	Hermann Schägger	Nat Protoc	2006	17406207	Yes
1288	2848	1424.0	90.04	45.0	Autophagy: renovation of cells and tissues.	Noboru Mizushima, Masaaki Komatsu	Cell	2011	22078875	No
1289	1423	1423.0	70.27	70.3	Perception of risk.	P Slovic	Science	1987	3563507	Yes
1290	1423	1423.0	38.19	38.2	Cellular basis of working memory.	P S Goldman-Rakic	Neuron	1995	7695894	No
1291	1423	1423.0	52.94	52.9	The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions.	B L Fredrickson	Am Psychol	2001	11315248	Yes
1292	1423	1423.0	36.91	36.9	Tumor angiogenesis.	Robert S Kerbel	N Engl J Med	2008	18463380	No
1293	1422	1422.0	42.42	42.4	Neurotrophins and neuronal plasticity.	H Thoenen	Science	1995	7570017	No
1294	2844	1422.0	87.53	43.8	Cloned glutamate receptors.	M Hollmann, S Heinemann	Annu Rev Neurosci	1994	8210177	No
1295	1422	1422.0	28.76	28.8	The microRNA Registry.	Sam Griffiths-Jones	Nucleic Acids Res	2004	14681370	Yes
1296	9948	1421.1	281.94	40.3	Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.	William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan	N Engl J Med	2002	11832527	Yes
1297	1421	1421.0	34.62	34.6	The hippo signaling pathway in development and cancer.	Duojia Pan	Dev Cell	2010	20951342	No
1298	2841	1420.5	111.17	55.6	Microenvironmental regulation of tumor progression and metastasis.	Daniela F Quail, Johanna A Joyce	Nat Med	2013	24202395	No
1299	15619	1419.9	431.3	39.2	PLINK: a tool set for whole-genome association and population-based linkage analyses.	Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C Sham	Am J Hum Genet	2007	17701901	Yes
1300	5677	1419.2	283.47	70.9	jModelTest 2: more models, new heuristics and parallel computing.	Diego Darriba, Guillermo L Taboada, Ramón Doallo, David Posada	Nat Methods	2012	22847109	Yes
1301	1419	1419.0	45.39	45.4	Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.	Ralph A Defronzo	Diabetes	2009	19336687	No
1302	1418	1418.0	46.06	46.1	Perceptual symbol systems.	L W Barsalou	Behav Brain Sci	1999	11301525	No
1303	1416	1416.0	0.0	0.0	Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma.	A Breslow	Ann Surg	1970	5477666	Yes
1304	1415	1415.0	58.83	58.8	Drugs of abuse: anatomy, pharmacology and function of reward pathways.	G F Koob	Trends Pharmacol Sci	1992	1604710	No
1305	1414	1414.0	0.0	0.0	High-speed scanning in human memory.	S Sternberg	Science	1966	5939936	Yes
1306	1414	1414.0	42.87	42.9	What we can do and what we cannot do with fMRI.	Nikos K Logothetis	Nature	2008	18548064	No
1307	2826	1413.0	90.49	45.2	Event-related EEG/MEG synchronization and desynchronization: basic principles.	G Pfurtscheller, F H Lopes da Silva	Clin Neurophysiol	1999	10576479	No
1308	1413	1413.0	36.47	36.5	Getting formal with dopamine and reward.	Wolfram Schultz	Neuron	2002	12383780	No
1309	1411	1411.0	0.0	0.0	Evolutionary rate at the molecular level.	M Kimura	Nature	1968	5637732	Yes
1310	2821	1410.5	73.75	36.9	The BCL-2 protein family: opposing activities that mediate cell death.	Richard J Youle, Andreas Strasser	Nat Rev Mol Cell Biol	2008	18097445	No
1311	1409	1409.0	33.8	33.8	The caveolae membrane system.	R G Anderson	Annu Rev Biochem	1998	9759488	No
1312	7040	1408.0	165.64	33.1	Stages of embryonic development of the zebrafish.	C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F Schilling	Dev Dyn	1995	8589427	Yes
1313	2816	1408.0	110.23	55.1	Shifting the genomic gold standard for the prokaryotic species definition.	Michael Richter, Ramon Rosselló-Móra	Proc Natl Acad Sci U S A	2009	19855009	Yes
1314	1407	1407.0	39.97	40.0	Adipose tissue, adipokines, and inflammation.	Giamila Fantuzzi	J Allergy Clin Immunol	2005	15867843	No
1315	2814	1407.0	97.62	48.8	Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference.	Stephen M Smith, Thomas E Nichols	Neuroimage	2009	18501637	Yes
1316	2813	1406.5	60.34	30.2	Upstream and downstream of mTOR.	Nissim Hay, Nahum Sonenberg	Genes Dev	2004	15314020	No
1317	4219	1406.3	112.64	37.5	Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons.	A Nicholls, K A Sharp, B Honig	Proteins	1991	1758883	Yes
1318	1406	1406.0	39.03	39.0	Effects of cytochalasin and phalloidin on actin.	J A Cooper	J Cell Biol	1987	3312229	No
1319	1406	1406.0	39.28	39.3	Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations.	M J Meaney	Annu Rev Neurosci	2001	11520931	No
1320	1405	1405.0	47.91	47.9	Multiple imputation: a primer.	J L Schafer	Stat Methods Med Res	1999	10347857	No
1321	1405	1405.0	28.32	28.3	Switching and signaling at the telomere.	E H Blackburn	Cell	2001	11572773	No
1322	1404	1404.0	49.57	49.6	The atom economy--a search for synthetic efficiency.	B M Trost	Science	1991	1962206	Yes
1323	1404	1404.0	37.35	37.4	Python: a programming language for software integration and development.	M F Sanner	J Mol Graph Model	1999	10660911	Yes
1324	2807	1403.5	83.93	42.0	Dali server: conservation mapping in 3D.	Liisa Holm, Päivi Rosenström	Nucleic Acids Res	2010	20457744	Yes
1325	1403	1403.0	0.0	0.0	The Gingival Index, the Plaque Index and the Retention Index Systems.	H Löe	J Periodontol	1967	5237684	Yes
1326	1403	1403.0	47.26	47.3	Gold-catalyzed organic reactions.	A Stephen K Hashmi	Chem Rev	2007	17580975	Yes
1327	1402	1402.0	33.96	34.0	PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms.	Michael F. Thomashow	Annu Rev Plant Physiol Plant Mol Biol	1999	15012220	Yes
1328	1400	1400.0	29.79	29.8	Hox genes in vertebrate development.	R Krumlauf	Cell	1994	7913880	No
1329	2797	1398.5	105.89	52.9	Palladium-catalyzed ligand-directed C-H functionalization reactions.	Thomas W Lyons, Melanie S Sanford	Chem Rev	2010	20078038	No
1330	4195	1398.3	109.08	36.4	Inflammation and atherosclerosis.	Peter Libby, Paul M Ridker, Attilio Maseri	Circulation	2002	11877368	No
1331	1398	1398.0	50.72	50.7	Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges.	Leonardo Pantoni	Lancet Neurol	2010	20610345	No
1332	1397	1397.0	44.07	44.1	Determination of minimum inhibitory concentrations.	J M Andrews	J Antimicrob Chemother	2001	11420333	Yes
1333	2794	1397.0	62.84	31.4	Signaling to NF-kappaB.	Matthew S Hayden, Sankar Ghosh	Genes Dev	2004	15371334	No
1334	8380	1396.7	179.07	29.8	Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.	A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C Mello	Nature	1998	9486653	Yes
1335	4188	1396.0	127.27	42.4	Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.	Z N Oltvai, C L Milliman, S J Korsmeyer	Cell	1993	8358790	Yes
1336	1396	1396.0	35.27	35.3	DNA topoisomerases.	J C Wang	Annu Rev Biochem	1996	8811192	No
1337	1395	1395.0	24.1	24.1	Neuronal specification in the spinal cord: inductive signals and transcriptional codes.	T M Jessell	Nat Rev Genet	2000	11262869	No
1338	1394	1394.0	47.63	47.6	The in vitro micronucleus technique.	M Fenech	Mutat Res	2000	11113469	No
1339	1394	1394.0	28.55	28.6	Neuroblastoma: biological insights into a clinical enigma.	Garrett M Brodeur	Nat Rev Cancer	2003	12612655	No
1340	6963	1392.6	183.6	36.7	Development and testing of a general amber force field.	Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A Case	J Comput Chem	2004	15116359	Yes
1341	5569	1392.2	0.0	0.0	Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.	D J Sahn, A DeMaria, J Kisslo, A Weyman	Circulation	1978	709763	Yes
1342	2783	1391.5	65.32	32.7	Fibroblasts in cancer.	Raghu Kalluri, Michael Zeisberg	Nat Rev Cancer	2006	16572188	No
1343	1391	1391.0	45.12	45.1	The basal ganglia: focused selection and inhibition of competing motor programs.	J W Mink	Prog Neurobiol	1996	9004351	No
1344	1390	1390.0	33.39	33.4	Trastuzumab--mechanism of action and use in clinical practice.	Clifford A Hudis	N Engl J Med	2007	17611206	No
1345	1389	1389.0	57.37	57.4	Glutamate: a neurotransmitter in mammalian brain.	F Fonnum	J Neurochem	1984	6139418	No
1346	1389	1389.0	26.5	26.5	Cyclin-dependent kinases: engines, clocks, and microprocessors.	D O Morgan	Annu Rev Cell Dev Biol	1997	9442875	No
1347	1389	1389.0	44.61	44.6	Trail Making Test A and B: normative data stratified by age and education.	Tom N Tombaugh	Arch Clin Neuropsychol	2004	15010086	Yes
1348	4165	1388.3	86.92	29.0	T-Coffee: A novel method for fast and accurate multiple sequence alignment.	C Notredame, D G Higgins, J Heringa	J Mol Biol	2000	10964570	Yes
1349	1387	1387.0	79.34	79.3	Role of endothelium in responses of vascular smooth muscle.	R F Furchgott	Circ Res	1983	6313250	No
1350	1387	1387.0	40.08	40.1	Dengue and dengue hemorrhagic fever.	D J Gubler	Clin Microbiol Rev	1998	9665979	No
1351	2774	1387.0	70.36	35.2	Shared principles in NF-kappaB signaling.	Matthew S Hayden, Sankar Ghosh	Cell	2008	18267068	No
1352	2773	1386.5	70.31	35.2	Human mesenchymal stem cells modulate allogeneic immune cell responses.	Sudeepta Aggarwal, Mark F Pittenger	Blood	2005	15494428	Yes
1353	1384	1384.0	0.0	0.0	Mode of cell migration to the superficial layers of fetal monkey neocortex.	P Rakic	J Comp Neurol	1972	4624784	Yes
1354	1384	1384.0	46.97	47.0	New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures.	R Y Tsien	Biochemistry	1980	6770893	Yes
1355	1383	1383.0	0.0	0.0	Areas, volumes, packing and protein structure.	F M Richards	Annu Rev Biophys Bioeng	1977	326146	No
1356	2766	1383.0	0.0	0.0	Maturation of the head of bacteriophage T4. I. DNA packaging events.	U K Laemmli, M Favre	J Mol Biol	1973	4204102	Yes
1357	4149	1383.0	214.29	71.4	The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs.	C A McHorney, J E Ware, A E Raczek	Med Care	1993	8450681	Yes
1358	2765	1382.5	75.44	37.7	The Fas death factor.	S Nagata, P Golstein	Science	1995	7533326	No
1359	2764	1382.0	95.14	47.6	Inositol phosphates and cell signalling.	M J Berridge, R F Irvine	Nature	1989	2550825	No
1360	1382	1382.0	0.0	0.0	Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals.	J N Dumont	J Morphol	1972	4109871	Yes
1361	1382	1382.0	35.6	35.6	A revolution in optical manipulation.	David G Grier	Nature	2003	12917694	No
1362	2763	1381.5	62.71	31.4	Why do cancers have high aerobic glycolysis?	Robert A Gatenby, Robert J Gillies	Nat Rev Cancer	2004	15516961	No
1363	2762	1381.0	209.23	104.6	A clinical method of functional assessment of the shoulder.	C R Constant, A H Murley	Clin Orthop Relat Res	1987	3791738	Yes
1364	1381	1381.0	30.67	30.7	Neurotrophins and their receptors: a convergence point for many signalling pathways.	Moses V Chao	Nat Rev Neurosci	2003	12671646	No
1365	1380	1380.0	0.0	0.0	Statistical analysis of enzyme kinetic data.	W W Cleland	Methods Enzymol	1979	502857	Yes
1366	1380	1380.0	39.68	39.7	From sensation to cognition.	M M Mesulam	Brain	1998	9648540	No
1367	2759	1379.5	99.05	49.5	Unified approach for molecular dynamics and density-functional theory.	Car, Parrinello	Phys Rev Lett	1985	10032153	Yes
1368	1379	1379.0	0.0	0.0	EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. IV. DISTRIBUTION OF MONOAMINE NERVE TERMINALS IN THE CENTRAL NERVOUS SYSTEM.	K FUXE	Acta Physiol Scand Suppl	1965	14319769	Yes
1369	4137	1379.0	125.43	41.8	The metabolic syndrome--a new worldwide definition.	K George M M Alberti, Paul Zimmet, Jonathan Shaw	Lancet	2005	16182882	Yes
1370	8273	1378.8	279.65	46.6	Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication.	Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E Walters	Arch Gen Psychiatry	2005	15939837	Yes
1371	5514	1378.5	115.68	28.9	A comparison of normalization methods for high density oligonucleotide array data based on variance and bias.	B M Bolstad, R A Irizarry, M Astrand, T P Speed	Bioinformatics	2003	12538238	Yes
1372	1378	1378.0	35.8	35.8	Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome.	B L Wajchenberg	Endocr Rev	2000	11133069	No
1373	2756	1378.0	94.36	47.2	Molecular mechanisms and clinical applications of angiogenesis.	Peter Carmeliet, Rakesh K Jain	Nature	2011	21593862	No
1374	1377	1377.0	27.68	27.7	How cells read TGF-beta signals.	J Massagué	Nat Rev Mol Cell Biol	2000	11252892	No
1375	1376	1376.0	52.09	52.1	Interleukin-1 and interleukin-1 antagonism.	C A Dinarello	Blood	1991	1826616	No
1376	1375	1375.0	51.07	51.1	Constructions of masculinity and their influence on men's well-being: a theory of gender and health.	W H Courtenay	Soc Sci Med	2000	10741575	No
1377	1374	1374.0	32.65	32.6	An extensively modified version of MolScript that includes greatly enhanced coloring capabilities.	R M Esnouf	J Mol Graph Model	1997	9385560	Yes
1378	1372	1372.0	30.63	30.6	Oxidative stress shortens telomeres.	Thomas von Zglinicki	Trends Biochem Sci	2002	12114022	Yes
1379	1372	1372.0	32.41	32.4	Perceptions of epigenetics.	Adrian Bird	Nature	2007	17522671	Yes
1380	1371	1371.0	72.22	72.2	The drug abuse screening test.	H A Skinner	Addict Behav	1982	7183189	Yes
1381	1370	1370.0	36.4	36.4	Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods.	Z Yang	J Mol Evol	1994	7932792	Yes
1382	1368	1368.0	38.58	38.6	Recognition of errors in three-dimensional structures of proteins.	M J Sippl	Proteins	1993	8108378	Yes
1383	4104	1368.0	116.18	38.7	A neural substrate of prediction and reward.	W Schultz, P Dayan, P R Montague	Science	1997	9054347	No
1384	1368	1368.0	42.77	42.8	Leptospirosis.	P N Levett	Clin Microbiol Rev	2001	11292640	No
1385	1368	1368.0	24.6	24.6	Cell cycle checkpoint signaling through the ATM and ATR kinases.	R T Abraham	Genes Dev	2001	11544175	No
1386	2734	1367.0	63.91	32.0	Complex networks orchestrate epithelial-mesenchymal transitions.	Jean Paul Thiery, Jonathan P Sleeman	Nat Rev Mol Cell Biol	2006	16493418	No
1387	2733	1366.5	71.58	35.8	A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids.	D Wessel, U I Flügge	Anal Biochem	1984	6731838	Yes
1388	4098	1366.0	117.31	39.1	Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey.	Earl S Ford, Wayne H Giles, William H Dietz	JAMA	2002	11790215	Yes
1389	1366	1366.0	0.0	0.0	A METHOD OF MEASURING EYE MOVEMENT USING A SCLERAL SEARCH COIL IN A MAGNETIC FIELD.	D A ROBINSON	IEEE Trans Biomed Eng	1963	14121113	Yes
1390	2731	1365.5	54.13	27.1	Cellular motility driven by assembly and disassembly of actin filaments.	Thomas D Pollard, Gary G Borisy	Cell	2003	12600310	No
1391	1365	1365.0	75.63	75.6	Determinants of low birth weight: methodological assessment and meta-analysis.	M S Kramer	Bull World Health Organ	1987	3322602	No
1392	1365	1365.0	49.51	49.5	Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events?	George A Bonanno	Am Psychol	2004	14736317	No
1393	2727	1363.5	128.47	64.2	The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger.	A J Stunkard, S Messick	J Psychosom Res	1985	3981480	Yes
1394	4089	1363.0	96.35	32.1	An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database.	J K Eng, A L McCormack, J R Yates	J Am Soc Mass Spectrom	1994	24226387	Yes
1395	2725	1362.5	134.22	67.1	Assays of glutathione peroxidase.	L Flohé, W A Günzler	Methods Enzymol	1984	6727659	Yes
1396	1362	1362.0	43.0	43.0	Cell biology and molecular basis of denitrification.	W G Zumft	Microbiol Mol Biol Rev	1997	9409151	No
1397	1362	1362.0	33.56	33.6	Introduction to NF-kappaB: players, pathways, perspectives.	T D Gilmore	Oncogene	2006	17072321	No
1398	2722	1361.0	61.11	30.6	Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases.	Gary L Johnson, Razvan Lapadat	Science	2002	12471242	No
1399	1360	1360.0	0.0	0.0	The micronucleus test.	W Schmid	Mutat Res	1975	48190	Yes
1400	2720	1360.0	80.57	40.3	Protein folding in the cell.	M J Gething, J Sambrook	Nature	1992	1731198	No
1401	2719	1359.5	106.9	53.5	Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability.	F Denizot, R Lang	J Immunol Methods	1986	3486233	Yes
1402	1359	1359.0	0.0	0.0	A modified card sorting test sensitive to frontal lobe defects.	H E Nelson	Cortex	1976	1009768	Yes
1403	2718	1359.0	0.0	0.0	EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.	A DAHLSTROEM, K FUXE	Acta Physiol Scand Suppl	1964	14229500	Yes
1404	4075	1358.3	155.37	51.8	Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.	H Esterbauer, R J Schaur, H Zollner	Free Radic Biol Med	1991	1937131	No
1405	1358	1358.0	31.86	31.9	An approximately unbiased test of phylogenetic tree selection.	Hidetoshi Shimodaira	Syst Biol	2002	12079646	Yes
1406	1358	1358.0	55.02	55.0	Large-scale brain networks and psychopathology: a unifying triple network model.	Vinod Menon	Trends Cogn Sci	2011	21908230	No
1407	5430	1357.5	170.93	42.7	Functional connectivity in the motor cortex of resting human brain using echo-planar MRI.	B Biswal, F Z Yetkin, V M Haughton, J S Hyde	Magn Reson Med	1995	8524021	Yes
1408	4072	1357.3	79.28	26.4	Notch signaling: cell fate control and signal integration in development.	S Artavanis-Tsakonas, M D Rand, R J Lake	Science	1999	10221902	No
1409	13566	1356.6	553.52	55.4	Measurement of protein using bicinchoninic acid.	P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C Klenk	Anal Biochem	1985	3843705	Yes
1410	2712	1356.0	0.0	0.0	Plaque formation and isolation of pure lines with poliomyelitis viruses.	R DULBECCO, M VOGT	J Exp Med	1954	13130792	Yes
1411	1356	1356.0	0.0	0.0	POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES.	D E Goldman	J Gen Physiol	1943	19873371	Yes
1412	2711	1355.5	57.88	28.9	Automated MAD and MIR structure solution.	T C Terwilliger, J Berendzen	Acta Crystallogr D Biol Crystallogr	1999	10089316	Yes
1413	13549	1354.9	527.77	52.8	The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.	F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S Luthra	Arthritis Rheum	1988	3358796	Yes
1414	6766	1353.2	191.53	38.3	Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.	Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan Hsu	N Engl J Med	2004	15385656	Yes
1415	1353	1353.0	40.8	40.8	Solvent-accessible surfaces of proteins and nucleic acids.	M L Connolly	Science	1983	6879170	Yes
1416	2706	1353.0	72.61	36.3	Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry.	Robert Visse, Hideaki Nagase	Circ Res	2003	12730128	No
1417	1353	1353.0	62.01	62.0	Antibiotics in the aquatic environment--a review--part I.	Klaus Kümmerer	Chemosphere	2009	19185900	No
1418	2705	1352.5	57.88	28.9	Fitting a mixture model by expectation maximization to discover motifs in biopolymers.	T L Bailey, C Elkan	Proc Int Conf Intell Syst Mol Biol	1994	7584402	Yes
1419	1352	1352.0	54.51	54.5	Large-scale neurocognitive networks and distributed processing for attention, language, and memory.	M M Mesulam	Ann Neurol	1990	2260847	No
1420	1352	1352.0	53.55	53.5	Intracellular calcium homeostasis.	E Carafoli	Annu Rev Biochem	1987	3304139	No
1421	1352	1352.0	0.0	0.0	Simple memory: a theory for archicortex.	D Marr	Philos Trans R Soc Lond B Biol Sci	1971	4399412	Yes
1422	1352	1352.0	57.93	57.9	A cortical network for directed attention and unilateral neglect.	M M Mesulam	Ann Neurol	1981	7032417	No
1423	1352	1352.0	43.59	43.6	Oxidative stress: oxidants and antioxidants.	H Sies	Exp Physiol	1997	9129943	No
1424	2703	1351.5	118.73	59.4	Pain assessment: global use of the Brief Pain Inventory.	C S Cleeland, K M Ryan	Ann Acad Med Singap	1994	8080219	No
1425	2702	1351.0	0.0	0.0	A fluorometric method for determination of oxidized and reduced glutathione in tissues.	P J Hissin, R Hilf	Anal Biochem	1976	962076	Yes
1426	4053	1351.0	92.21	30.7	Efficient selection for high-expression transfectants with a novel eukaryotic vector.	H Niwa, K Yamamura, J Miyazaki	Gene	1991	1660837	Yes
1427	1350	1350.0	53.2	53.2	Pineal melatonin: cell biology of its synthesis and of its physiological interactions.	R J Reiter	Endocr Rev	1991	1649044	No
1428	2700	1350.0	58.66	29.3	NF-kappaB regulation in the immune system.	Qiutang Li, Inder M Verma	Nat Rev Immunol	2002	12360211	No
1429	1350	1350.0	27.55	27.6	Protein degradation and protection against misfolded or damaged proteins.	Alfred L Goldberg	Nature	2003	14685250	No
1430	2699	1349.5	83.95	42.0	The precuneus: a review of its functional anatomy and behavioural correlates.	Andrea E Cavanna, Michael R Trimble	Brain	2006	16399806	No
1431	1349	1349.0	0.0	0.0	Pedigrees of some mutant strains of Escherichia coli K-12.	B J Bachmann	Bacteriol Rev	1972	4568763	No
1432	1349	1349.0	81.18	81.2	Brain dopamine receptors.	P Seeman	Pharmacol Rev	1980	6117090	No
1433	1349	1349.0	70.62	70.6	Interleukin-1.	C A Dinarello	Rev Infect Dis	1984	6369481	No
1434	1349	1349.0	73.19	73.2	Adverse health effects of high-effort/low-reward conditions.	J Siegrist	J Occup Health Psychol	1996	9547031	No
1435	1348	1348.0	0.0	0.0	The relationship between the spleen colony-forming cell and the haemopoietic stem cell.	R Schofield	Blood Cells	1978	747780	Yes
1436	1348	1348.0	0.0	0.0	Chromatin structure: a repeating unit of histones and DNA.	R D Kornberg	Science	1974	4825889	Yes
1437	5391	1347.8	146.34	36.6	Improved optimization for the robust and accurate linear registration and motion correction of brain images.	Mark Jenkinson, Peter Bannister, Michael Brady, Stephen Smith	Neuroimage	2002	12377157	Yes
1438	1347	1347.0	0.0	0.0	Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.	E M Witkin	Bacteriol Rev	1976	795416	No
1439	1347	1347.0	40.21	40.2	Task switching.	Stephen Monsell	Trends Cogn Sci	2003	12639695	Yes
1440	5387	1346.8	124.79	31.2	MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform.	Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi Miyata	Nucleic Acids Res	2002	12136088	Yes
1441	1346	1346.0	45.79	45.8	A computational procedure for determining energetically favorable binding sites on biologically important macromolecules.	P J Goodford	J Med Chem	1985	3892003	Yes
1442	2692	1346.0	0.0	0.0	Receptive fields and functional architecture of monkey striate cortex.	D H Hubel, T N Wiesel	J Physiol	1968	4966457	Yes
1443	2691	1345.5	0.0	0.0	Polymyositis and dermatomyositis (first of two parts).	A Bohan, J B Peter	N Engl J Med	1975	1090839	No
1444	1345	1345.0	37.48	37.5	Structural design and molecular evolution of a cytokine receptor superfamily.	J F Bazan	Proc Natl Acad Sci U S A	1990	2169613	Yes
1445	1345	1345.0	27.79	27.8	Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing.	D I Svergun	Biophys J	1999	10354416	Yes
1446	2689	1344.5	80.33	40.2	Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.	P J Southern, P Berg	J Mol Appl Genet	1982	6286831	Yes
1447	1344	1344.0	52.19	52.2	Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.	M Zasloff	Proc Natl Acad Sci U S A	1987	3299384	Yes
1448	2687	1343.5	90.81	45.4	Alzheimer's disease.	Henry W Querfurth, Frank M LaFerla	N Engl J Med	2010	20107219	No
1449	1343	1343.0	59.59	59.6	The linear-quadratic formula and progress in fractionated radiotherapy.	J F Fowler	Br J Radiol	1989	2670032	No
1450	2686	1343.0	76.85	38.4	Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation.	M A Nitsche, W Paulus	J Physiol	2000	10990547	Yes
1451	1343	1343.0	37.36	37.4	Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia.	Shitij Kapur	Am J Psychiatry	2003	12505794	No
1452	2686	1343.0	60.91	30.5	Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions.	E Krissinel, K Henrick	Acta Crystallogr D Biol Crystallogr	2004	15572779	Yes
1453	2684	1342.0	91.71	45.9	Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI.	P J Basser, C Pierpaoli	J Magn Reson B	1996	8661285	Yes
1454	1342	1342.0	28.47	28.5	Cell cycle checkpoints: preventing an identity crisis.	S J Elledge	Science	1996	8939848	No
1455	1342	1342.0	32.11	32.1	From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.	W A Catterall	Neuron	2000	10798388	No
1456	1342	1342.0	32.34	32.3	Far-field optical nanoscopy.	Stefan W Hell	Science	2007	17525330	No
1457	1341	1341.0	58.52	58.5	Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?	B Halliwell	Lancet	1994	7915779	No
1458	4022	1340.7	140.84	46.9	Atrial fibrillation as an independent risk factor for stroke: the Framingham Study.	P A Wolf, R D Abbott, W B Kannel	Stroke	1991	1866765	Yes
1459	1340	1340.0	0.0	0.0	Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids.	D AMINOFF	Biochem J	1961	13860975	Yes
1460	1340	1340.0	72.24	72.2	Statistics corner: A guide to appropriate use of correlation coefficient in medical research.	M M Mukaka	Malawi Med J	2012	23638278	Yes
1461	1339	1339.0	33.58	33.6	Mammalian G1 cyclins.	C J Sherr	Cell	1993	8513492	No
1462	2678	1339.0	56.52	28.3	Missing pieces in the NF-kappaB puzzle.	Sankar Ghosh, Michael Karin	Cell	2002	11983155	No
1463	1339	1339.0	0.0	0.0	Cerebral vascular accidents in patients over the age of 60. II. Prognosis.	J RANKIN	Scott Med J	1957	13432835	Yes
1464	1339	1339.0	37.73	37.7	Pathogen recognition and inflammatory signaling in innate immune defenses.	Trine H Mogensen	Clin Microbiol Rev	2009	19366914	No
1465	2677	1338.5	101.0	50.5	Separate visual pathways for perception and action.	M A Goodale, A D Milner	Trends Neurosci	1992	1374953	No
1466	1338	1338.0	27.51	27.5	Intrinsically unstructured proteins.	Peter Tompa	Trends Biochem Sci	2002	12368089	No
1467	1337	1337.0	41.26	41.3	Oxidative stress hypothesis in Alzheimer's disease.	W R Markesbery	Free Radic Biol Med	1997	9165306	No
1468	1337	1337.0	38.12	38.1	The corticosteroid receptor hypothesis of depression.	F Holsboer	Neuropsychopharmacology	2000	11027914	No
1469	1335	1335.0	34.65	34.6	In vivo near-infrared fluorescence imaging.	John V Frangioni	Curr Opin Chem Biol	2003	14580568	No
1470	5339	1334.8	172.25	43.1	Comorbidity measures for use with administrative data.	A Elixhauser, C Steiner, D R Harris, R M Coffey	Med Care	1998	9431328	Yes
1471	5338	1334.5	249.96	62.5	16S ribosomal DNA amplification for phylogenetic study.	W G Weisburg, S M Barns, D A Pelletier, D J Lane	J Bacteriol	1991	1987160	Yes
1472	2669	1334.5	75.08	37.5	Quantum dot bioconjugates for ultrasensitive nonisotopic detection.	W C Chan, S Nie	Science	1998	9748158	Yes
1473	1334	1334.0	44.74	44.7	Glycobiology: Toward Understanding the Function of Sugars.	Raymond A. Dwek	Chem Rev	1996	11848770	Yes
1474	2666	1333.0	109.01	54.5	Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease.	R A DeFronzo, E Ferrannini	Diabetes Care	1991	2044434	No
1475	2666	1333.0	57.87	28.9	Toll-like receptor control of the adaptive immune responses.	Akiko Iwasaki, Ruslan Medzhitov	Nat Immunol	2004	15454922	No
1476	1332	1332.0	32.13	32.1	Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1.	G L Semenza	Annu Rev Cell Dev Biol	1999	10611972	No
1477	1331	1331.0	34.31	34.3	Hypertrophic cardiomyopathy: a systematic review.	Barry J Maron	JAMA	2002	11886323	No
1478	1331	1331.0	27.55	27.6	Immunosuppressive networks in the tumour environment and their therapeutic relevance.	Weiping Zou	Nat Rev Cancer	2005	15776005	No
1479	2662	1331.0	79.05	39.5	Multiple sclerosis.	Alastair Compston, Alasdair Coles	Lancet	2008	18970977	Yes
1480	2659	1329.5	101.67	50.8	Neurocircuitry of addiction.	George F Koob, Nora D Volkow	Neuropsychopharmacology	2010	19710631	No
1481	3987	1329.0	100.81	33.6	Click Chemistry: Diverse Chemical Function from a Few Good Reactions.	Hartmuth C. Kolb, M. G. Finn, K. Barry Sharpless	Angew Chem Int Ed Engl	2001	11433435	Yes
1482	1329	1329.0	26.17	26.2	Vienna RNA secondary structure server.	Ivo L Hofacker	Nucleic Acids Res	2003	12824340	Yes
1483	1329	1329.0	34.41	34.4	Thiazolidinediones.	Hannele Yki-Järvinen	N Engl J Med	2004	15356308	No
1484	2655	1327.5	0.0	0.0	New method for quantitative determination of uronic acids.	N Blumenkrantz, G Asboe-Hansen	Anal Biochem	1973	4269305	Yes
1485	13275	1327.5	351.86	35.2	Multilineage potential of adult human mesenchymal stem cells.	M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R Marshak	Science	1999	10102814	Yes
1486	1327	1327.0	58.55	58.5	Intermediate filaments as mechanical integrators of cellular space.	E Lazarides	Nature	1980	7188712	Yes
1487	2654	1327.0	0.0	0.0	Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature.	J MARMUR, P DOTY	J Mol Biol	1962	14470099	Yes
1488	1326	1326.0	0.0	0.0	Stereological principles for morphometry in electron microscopic cytology.	E R Weibel	Int Rev Cytol	1969	4899604	No
1489	2652	1326.0	68.16	34.1	The incidence of congenital heart disease.	Julien I E Hoffman, Samuel Kaplan	J Am Coll Cardiol	2002	12084585	No
1490	2650	1325.0	54.79	27.4	Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.	O Tetsu, F McCormick	Nature	1999	10201372	Yes
1491	2649	1324.5	63.06	31.5	Cell migration: a physically integrated molecular process.	D A Lauffenburger, A F Horwitz	Cell	1996	8608589	No
1492	2648	1324.0	52.34	26.2	The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.	Michael H Glickman, Aaron Ciechanover	Physiol Rev	2002	11917093	No
1493	1324	1324.0	37.3	37.3	Integration, scaling, space-group assignment and post-refinement.	Wolfgang Kabsch	Acta Crystallogr D Biol Crystallogr	2010	20124693	Yes
1494	7943	1323.8	261.6	43.6	Positional cloning of the mouse obese gene and its human homologue.	Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M Friedman	Nature	1994	7984236	Yes
1495	1323	1323.0	35.84	35.8	The biology of incretin hormones.	Daniel J Drucker	Cell Metab	2006	16517403	No
1496	2645	1322.5	92.4	46.2	Density functionals with broad applicability in chemistry.	Yan Zhao, Donald G Truhlar	Acc Chem Res	2008	18186612	Yes
1497	1322	1322.0	51.01	51.0	Health consequences of obesity in youth: childhood predictors of adult disease.	W H Dietz	Pediatrics	1998	12224658	No
1498	1321	1321.0	50.07	50.1	A new automated colorimetric method for measuring total oxidant status.	Ozcan Erel	Clin Biochem	2005	16214125	Yes
1499	1321	1321.0	44.32	44.3	Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements.	James J P Stewart	J Mol Model	2007	17828561	Yes
1500	1320	1320.0	0.0	0.0	Fluorescence energy transfer as a spectroscopic ruler.	L Stryer	Annu Rev Biochem	1978	354506	No
1501	1320	1320.0	0.0	0.0	Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay.	B E Murphy	J Clin Endocrinol Metab	1967	4291524	Yes
1502	1320	1320.0	49.42	49.4	Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders.	Berislav V Zlokovic	Nat Rev Neurosci	2011	22048062	No
1503	1319	1319.0	0.0	0.0	Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system.	D M Neville	J Biol Chem	1971	5127429	Yes
1504	1319	1319.0	29.39	29.4	DNA in a material world.	Nadrian C Seeman	Nature	2003	12540916	No
1505	1319	1319.0	50.25	50.2	Cognitive reserve.	Yaakov Stern	Neuropsychologia	2009	19467352	No
1506	3952	1317.3	114.51	38.2	The rapid generation of mutation data matrices from protein sequences.	D T Jones, W R Taylor, J M Thornton	Comput Appl Biosci	1992	1633570	Yes
1507	1317	1317.0	50.3	50.3	Validation of a decisional conflict scale.	A M O'Connor	Med Decis Making	1995	7898294	Yes
1508	1317	1317.0	27.5	27.5	RNA silencing in plants.	David Baulcombe	Nature	2004	15372043	No
1509	1317	1317.0	49.2	49.2	Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances.	Joseph J Volpe	Lancet Neurol	2009	19081519	No
1510	2633	1316.5	113.96	57.0	The transtheoretical model of health behavior change.	J O Prochaska, W F Velicer	Am J Health Promot	1997	10170434	No
1511	1316	1316.0	26.87	26.9	Germinal centers.	I C MacLennan	Annu Rev Immunol	1994	8011279	No
1512	1316	1316.0	34.55	34.5	Insulin and insulin-like growth factor signalling in neoplasia.	Michael Pollak	Nat Rev Cancer	2008	19029956	No
1513	3946	1315.3	96.06	32.0	Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.	J E Darnell, I M Kerr, G R Stark	Science	1994	8197455	No
1514	1314	1314.0	46.78	46.8	Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy.	Y Ben-Ari	Neuroscience	1985	2859548	No
1515	1314	1314.0	0.0	0.0	Selforganization of matter and the evolution of biological macromolecules.	M Eigen	Naturwissenschaften	1971	4942363	No
1516	1313	1313.0	28.09	28.1	Regulatory T cells, tumour immunity and immunotherapy.	Weiping Zou	Nat Rev Immunol	2006	16557261	No
1517	1311	1311.0	48.05	48.0	The role of the amygdala in fear and anxiety.	M Davis	Annu Rev Neurosci	1992	1575447	No
1518	1311	1311.0	28.39	28.4	The Buccaneer software for automated model building. 1. Tracing protein chains.	Kevin Cowtan	Acta Crystallogr D Biol Crystallogr	2006	16929101	Yes
1519	2621	1310.5	0.0	0.0	Determination of malonaldehyde precursor in tissues by thiobarbituric acid test.	M Mihara, M Uchiyama	Anal Biochem	1978	655387	Yes
1520	1310	1310.0	33.49	33.5	Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone.	M B Luskin	Neuron	1993	8338665	Yes
1521	1310	1310.0	35.84	35.8	An economic method for the fluorescent labeling of PCR fragments.	M Schuelke	Nat Biotechnol	2000	10657137	Yes
1522	1309	1309.0	0.0	0.0	Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study.	E G GRAY	J Anat	1959	13829103	Yes
1523	7854	1309.0	276.68	46.1	Cancer statistics, 2009.	Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J Thun	CA Cancer J Clin	2009	19474385	Yes
1524	2617	1308.5	67.02	33.5	The human plasma proteome: history, character, and diagnostic prospects.	N Leigh Anderson, Norman G Anderson	Mol Cell Proteomics	2002	12488461	No
1525	1307	1307.0	33.43	33.4	Pathogenesis of group A streptococcal infections.	M W Cunningham	Clin Microbiol Rev	2000	10885988	No
1526	2613	1306.5	159.91	80.0	Interrater reliability of a modified Ashworth scale of muscle spasticity.	R W Bohannon, M B Smith	Phys Ther	1987	3809245	Yes
1527	1305	1305.0	0.0	0.0	Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.	U Ungerstedt	Acta Physiol Scand Suppl	1971	4332693	Yes
1528	1305	1305.0	31.42	31.4	Mechanisms of bone metastasis.	G David Roodman	N Engl J Med	2004	15084698	No
1529	1305	1305.0	62.46	62.5	The emerging role of lncRNAs in cancer.	Maite Huarte	Nat Med	2015	26540387	No
1530	1304	1304.0	52.91	52.9	The crisis in antibiotic resistance.	H C Neu	Science	1992	1509257	No
1531	1304	1304.0	46.3	46.3	Domino Reactions in Organic Synthesis.	Lutz F. Tietze	Chem Rev	1996	11848746	Yes
1532	2607	1303.5	133.32	66.7	A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity.	J G Snodgrass, M Vanderwart	J Exp Psychol Hum Learn	1980	7373248	Yes
1533	1303	1303.0	33.03	33.0	Five rules for the evolution of cooperation.	Martin A Nowak	Science	2006	17158317	No
1534	1303	1303.0	42.69	42.7	Systemic lupus erythematosus.	George C Tsokos	N Engl J Med	2011	22129255	No
1535	2604	1302.0	69.9	35.0	Adipose tissue as an endocrine organ.	Erin E Kershaw, Jeffrey S Flier	J Clin Endocrinol Metab	2004	15181022	No
1536	1302	1302.0	53.43	53.4	Falls in older people: epidemiology, risk factors and strategies for prevention.	Laurence Z Rubenstein	Age Ageing	2006	16926202	No
1537	1302	1302.0	42.47	42.5	Surface plasmon resonance sensors for detection of chemical and biological species.	Jirí Homola	Chem Rev	2008	18229953	No
1538	2602	1301.0	58.78	29.4	Coordination of circadian timing in mammals.	Steven M Reppert, David R Weaver	Nature	2002	12198538	No
1539	2600	1300.0	59.32	29.7	The Ki-67 protein: from the known and the unknown.	T Scholzen, J Gerdes	J Cell Physiol	2000	10653597	No
1540	2599	1299.5	82.9	41.5	An information-maximization approach to blind separation and blind deconvolution.	A J Bell, T J Sejnowski	Neural Comput	1995	7584893	Yes
1541	1299	1299.0	35.66	35.7	Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology.	B Winkel-Shirley	Plant Physiol	2001	11402179	No
1542	1298	1298.0	46.55	46.5	Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.	G C Walker	Microbiol Rev	1984	6371470	No
1543	1298	1298.0	39.35	39.4	The world health report 2002 - reducing risks, promoting healthy life.	J J Guilbert	Educ Health (Abingdon)	2003	14741909	Yes
1544	2595	1297.5	0.0	0.0	Variations in the pattern of pubertal changes in boys.	W A Marshall, J M Tanner	Arch Dis Child	1970	5440182	Yes
1545	1297	1297.0	0.0	0.0	Paced auditory serial-addition task: a measure of recovery from concussion.	D M Gronwall	Percept Mot Skills	1977	866038	Yes
1546	1297	1297.0	52.64	52.6	Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage.	D W Choi	Trends Neurosci	1988	2469166	No
1547	1297	1297.0	43.43	43.4	The complete general secretory pathway in gram-negative bacteria.	A P Pugsley	Microbiol Rev	1993	8096622	No
1548	6485	1297.0	138.39	27.7	Prospective identification of tumorigenic breast cancer cells.	Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F Clarke	Proc Natl Acad Sci U S A	2003	12629218	Yes
1549	1297	1297.0	42.93	42.9	The many roles for fluorine in medicinal chemistry.	William K Hagmann	J Med Chem	2008	18570365	Yes
1550	2593	1296.5	84.94	42.5	Mechanisms of salinity tolerance.	Rana Munns, Mark Tester	Annu Rev Plant Biol	2008	18444910	No
1551	1296	1296.0	33.42	33.4	A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin.	D A Gewirtz	Biochem Pharmacol	1999	10075079	No
1552	1296	1296.0	33.3	33.3	Neurovascular regulation in the normal brain and in Alzheimer's disease.	Costantino Iadecola	Nat Rev Neurosci	2004	15100718	No
1553	1295	1295.0	33.41	33.4	Structural features in eukaryotic mRNAs that modulate the initiation of translation.	M Kozak	J Biol Chem	1991	1939050	No
1554	1295	1295.0	29.85	29.9	Neurotrophins as synaptic modulators.	M M Poo	Nat Rev Neurosci	2001	11253356	No
1555	1295	1295.0	0.0	0.0	THE ESTIMATION OF PEPSIN, TRYPSIN, PAPAIN, AND CATHEPSIN WITH HEMOGLOBIN.	M L Anson	J Gen Physiol	1938	19873094	Yes
1556	2589	1294.5	73.01	36.5	Empirical threshold values for quantitative trait mapping.	G A Churchill, R W Doerge	Genetics	1994	7851788	Yes
1557	1294	1294.0	40.88	40.9	n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases.	Philip C Calder	Am J Clin Nutr	2006	16841861	No
1558	1293	1293.0	32.34	32.3	An analysis of vertebrate mRNA sequences: intimations of translational control.	M Kozak	J Cell Biol	1991	1955461	No
1559	1293	1293.0	35.08	35.1	The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.	D M Kingsley	Genes Dev	1994	8299934	No
1560	1293	1293.0	0.0	0.0	ENZYMATIC BASIS FOR ACTIVE TRANSPORT OF NA+ AND K+ ACROSS CELL MEMBRANE.	J C SKOU	Physiol Rev	1965	14337569	No
1561	1292	1292.0	0.0	0.0	Impulses and Physiological States in Theoretical Models of Nerve Membrane.	R Fitzhugh	Biophys J	1961	19431309	Yes
1562	2581	1290.5	106.24	53.1	Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants.	Sarvajeet Singh Gill, Narendra Tuteja	Plant Physiol Biochem	2010	20870416	No
1563	1290	1290.0	0.0	0.0	Why genes in pieces?	W Gilbert	Nature	1978	622185	Yes
1564	1290	1290.0	0.0	0.0	R factor transfer in Rhizobium leguminosarum.	J E Beringer	J Gen Microbiol	1974	4612098	Yes
1565	3870	1290.0	162.13	54.0	A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study.	J R Le Gall, S Lemeshow, F Saulnier	JAMA	1993	8254858	Yes
1566	1290	1290.0	30.43	30.4	The NCI60 human tumour cell line anticancer drug screen.	Robert H Shoemaker	Nat Rev Cancer	2006	16990858	No
1567	2580	1290.0	69.33	34.7	Malignant gliomas in adults.	Patrick Y Wen, Santosh Kesari	N Engl J Med	2008	18669428	No
1568	3869	1289.7	105.49	35.2	Two-photon laser scanning fluorescence microscopy.	W Denk, J H Strickler, W W Webb	Science	1990	2321027	Yes
1569	7736	1289.3	271.48	45.2	New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0.	Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier Gascuel	Syst Biol	2010	20525638	Yes
1570	1289	1289.0	0.0	0.0	Complete nucleotide sequence of the Escherichia coli plasmid pBR322.	J G Sutcliffe	Cold Spring Harb Symp Quant Biol	1979	383387	Yes
1571	5153	1288.2	230.79	57.7	Reporting results of cancer treatment.	A B Miller, B Hoogstraten, M Staquet, A Winkler	Cancer	1981	7459811	Yes
1572	1288	1288.0	0.0	0.0	In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain.	T R Chen	Exp Cell Res	1977	65285	Yes
1573	2576	1288.0	61.84	30.9	Neurotrophins: roles in neuronal development and function.	E J Huang, L F Reichardt	Annu Rev Neurosci	2001	11520916	No
1574	5152	1288.0	299.6	74.9	The Satisfaction With Life Scale.	E Diener, R A Emmons, R J Larsen, S Griffin	J Pers Assess	1985	16367493	Yes
1575	2575	1287.5	108.65	54.3	Role of free radicals and catalytic metal ions in human disease: an overview.	B Halliwell, J M Gutteridge	Methods Enzymol	1990	2172697	No
1576	3862	1287.3	125.81	41.9	Dating of the human-ape splitting by a molecular clock of mitochondrial DNA.	M Hasegawa, H Kishino, T Yano	J Mol Evol	1985	3934395	Yes
1577	1287	1287.0	37.58	37.6	Precision mapping of quantitative trait loci.	Z B Zeng	Genetics	1994	8013918	Yes
1578	1286	1286.0	59.04	59.0	Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.	P Holzer	Pharmacol Rev	1991	1852779	No
1579	1286	1286.0	25.15	25.1	Aggresomes, inclusion bodies and protein aggregation.	R R Kopito	Trends Cell Biol	2000	11121744	No
1580	1285	1285.0	0.0	0.0	Stability of proteins: small globular proteins.	P L Privalov	Adv Protein Chem	1979	44431	No
1581	1285	1285.0	30.41	30.4	Tumor metastasis: mechanistic insights and clinical challenges.	Patricia S Steeg	Nat Med	2006	16892035	No
1582	1284	1284.0	34.51	34.5	A cell culture model for T lymphocyte clonal anergy.	R H Schwartz	Science	1990	2113314	Yes
1583	1284	1284.0	61.1	61.1	Modeling and variable selection in epidemiologic analysis.	S Greenland	Am J Public Health	1989	2916724	Yes
1584	1284	1284.0	47.69	47.7	Efficient analysis of experimental observations.	W J Dixon	Annu Rev Pharmacol Toxicol	1980	7387124	Yes
1585	3852	1284.0	99.95	33.3	Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets.	Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck Ørntoft	Cancer Res	2004	15289330	Yes
1586	1284	1284.0	61.57	61.6	Pro-resolving lipid mediators are leads for resolution physiology.	Charles N Serhan	Nature	2014	24899309	No
1587	5134	1283.5	150.83	37.7	p53 mutations in human cancers.	M Hollstein, D Sidransky, B Vogelstein, C C Harris	Science	1991	1905840	No
1588	2566	1283.0	63.9	31.9	Lipopolysaccharide endotoxins.	Christian R H Raetz, Chris Whitfield	Annu Rev Biochem	2002	12045108	No
1589	1283	1283.0	35.01	35.0	Myeloperoxidase: friend and foe.	Seymour J Klebanoff	J Leukoc Biol	2005	15689384	No
1590	1282	1282.0	0.0	0.0	A simple fluorometric assay for lipoperoxide in blood plasma.	K Yagi	Biochem Med	1976	962904	Yes
1591	1282	1282.0	41.66	41.7	Semiempirical hybrid density functional with perturbative second-order correlation.	Stefan Grimme	J Chem Phys	2006	16438568	Yes
1592	1281	1281.0	66.05	66.0	Gctf: Real-time CTF determination and correction.	Kai Zhang	J Struct Biol	2016	26592709	Yes
1593	1280	1280.0	53.5	53.5	Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement.	Virginia A Moyer	Ann Intern Med	2012	22801674	No
1594	11519	1279.9	432.95	48.1	STAR: ultrafast universal RNA-seq aligner.	Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R Gingeras	Bioinformatics	2013	23104886	Yes
1595	3839	1279.7	136.97	45.7	Estimating the mean and variance from the median, range, and the size of a sample.	Stela Pudar Hozo, Benjamin Djulbegovic, Iztok Hozo	BMC Med Res Methodol	2005	15840177	Yes
1596	2557	1278.5	89.73	44.9	Oxidative stress, glutamate, and neurodegenerative disorders.	J T Coyle, P Puttfarcken	Science	1993	7901908	No
1597	2556	1278.0	52.25	26.1	The evolutionary fate and consequences of duplicate genes.	M Lynch, J S Conery	Science	2000	11073452	No
1598	2556	1278.0	68.07	34.0	Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple.	F Q Schafer, G R Buettner	Free Radic Biol Med	2001	11368918	No
1599	1278	1278.0	27.99	28.0	Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy.	R K Jain	Nat Med	2001	11533692	No
1600	3833	1277.7	0.0	0.0	Impact of Event Scale: a measure of subjective stress.	M Horowitz, N Wilner, W Alvarez	Psychosom Med	1979	472086	Yes
1601	3833	1277.7	138.94	46.3	Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration.	Helga Thorvaldsdóttir, James T Robinson, Jill P Mesirov	Brief Bioinform	2013	22517427	Yes
1602	1277	1277.0	0.0	0.0	The inverse care law.	J T Hart	Lancet	1971	4100731	Yes
1603	1277	1277.0	75.6	75.6	Measurement of health state utilities for economic appraisal.	G W Torrance	J Health Econ	1986	10311607	No
1604	10209	1276.1	385.99	48.2	Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.	R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A Erlich	Science	1988	2448875	Yes
1605	2551	1275.5	59.6	29.8	Cancer metastasis: building a framework.	Gaorav P Gupta, Joan Massagué	Cell	2006	17110329	No
1606	1275	1275.0	34.22	34.2	On finding all suboptimal foldings of an RNA molecule.	M Zuker	Science	1989	2468181	No
1607	1275	1275.0	50.66	50.7	Cellular defenses against damage from reactive oxygen species.	B P Yu	Physiol Rev	1994	8295932	No
1608	3825	1275.0	139.48	46.5	Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions.	Aleksandr V Marenich, Christopher J Cramer, Donald G Truhlar	J Phys Chem B	2009	19366259	Yes
1609	1274	1274.0	39.14	39.1	Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease.	Michael F Holick	Am J Clin Nutr	2004	15585788	No
1610	2547	1273.5	85.65	42.8	EQ-5D: a measure of health status from the EuroQol Group.	R Rabin, F de Charro	Ann Med	2001	11491192	No
1611	16554	1273.4	484.27	37.3	Clustal W and Clustal X version 2.0.	M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G Higgins	Bioinformatics	2007	17846036	Yes
1612	1273	1273.0	39.64	39.6	Alpha-crystallin can function as a molecular chaperone.	J Horwitz	Proc Natl Acad Sci U S A	1992	1438232	Yes
1613	1273	1273.0	60.16	60.2	Probiotics in man and animals.	R Fuller	J Appl Bacteriol	1989	2666378	No
1614	1273	1273.0	35.36	35.4	HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy.	J M Coffin	Science	1995	7824947	Yes
1615	1272	1272.0	0.0	0.0	Which elements are excited in electrical stimulation of mammalian central nervous system: a review.	J B Ranck	Brain Res	1975	1102064	No
1616	1272	1272.0	55.04	55.0	The case-crossover design: a method for studying transient effects on the risk of acute events.	M Maclure	Am J Epidemiol	1991	1985444	Yes
1617	1272	1272.0	0.0	0.0	Amino acid difference formula to help explain protein evolution.	R Grantham	Science	1974	4843792	Yes
1618	1272	1272.0	58.02	58.0	Simple proton spectroscopic imaging.	W T Dixon	Radiology	1984	6089263	Yes
1619	1272	1272.0	30.24	30.2	Hematopoietic stem-cell transplantation.	Edward A Copelan	N Engl J Med	2006	16641398	No
1620	2542	1271.0	0.0	0.0	Multiple receptors for dopamine.	J W Kebabian, D B Calne	Nature	1979	215920	No
1621	2542	1271.0	82.45	41.2	Rapid and sensitive protein similarity searches.	D J Lipman, W R Pearson	Science	1985	2983426	Yes
1622	1270	1270.0	35.32	35.3	Use and misuse of the receiver operating characteristic curve in risk prediction.	Nancy R Cook	Circulation	2007	17309939	Yes
1623	1269	1269.0	23.5	23.5	Histone acetylation and transcriptional regulatory mechanisms.	K Struhl	Genes Dev	1998	9499396	No
1624	1269	1269.0	23.86	23.9	Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy.	M G Gustafsson	J Microsc	2000	10810003	Yes
1625	1268	1268.0	32.94	32.9	Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis.	S C Manolagas	Endocr Rev	2000	10782361	No
1626	5070	1267.5	148.4	37.1	Use of T7 RNA polymerase to direct expression of cloned genes.	F W Studier, A H Rosenberg, J J Dunn, J W Dubendorff	Methods Enzymol	1990	2199796	Yes
1627	2535	1267.5	90.79	45.4	Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons.	M Karas, F Hillenkamp	Anal Chem	1988	3239801	Yes
1628	1267	1267.0	0.0	0.0	Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment.	K O Fagerström	Addict Behav	1978	735910	Yes
1629	1266	1266.0	63.91	63.9	Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides.	P Holzer	Neuroscience	1988	3288903	No
1630	1265	1265.0	34.02	34.0	Lead- and drug-like compounds: the rule-of-five revolution.	Christopher A Lipinski	Drug Discov Today Technol	2004	24981612	Yes
1631	2529	1264.5	0.0	0.0	Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation.	R L Heath, L Packer	Arch Biochem Biophys	1968	5655425	Yes
1632	5058	1264.5	177.36	44.3	The validity of the Hospital Anxiety and Depression Scale. An updated literature review.	Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag Neckelmann	J Psychosom Res	2002	11832252	No
1633	2529	1264.5	82.79	41.4	Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research.	Sally S Dickerson, Margaret E Kemeny	Psychol Bull	2004	15122924	Yes
1634	2528	1264.0	56.38	28.2	The Bcl2 family: regulators of the cellular life-or-death switch.	Suzanne Cory, Jerry M Adams	Nat Rev Cancer	2002	12209154	No
1635	1264	1264.0	31.54	31.5	The molecular logic of endocannabinoid signalling.	Daniele Piomelli	Nat Rev Neurosci	2003	14595399	No
1636	1264	1264.0	29.03	29.0	Cancer epigenomics: DNA methylomes and histone-modification maps.	Manel Esteller	Nat Rev Genet	2007	17339880	No
1637	1263	1263.0	38.06	38.1	Binary Agrobacterium vectors for plant transformation.	M Bevan	Nucleic Acids Res	1984	6095209	Yes
1638	1263	1263.0	45.88	45.9	El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. Subcommittee on Motor Neuron Diseases/Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial "Clinical limits of amyotrophic lateral sclerosis" workshop contributors.	B R Brooks	J Neurol Sci	1994	7807156	Yes
1639	1263	1263.0	41.6	41.6	Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat.	P A Bradford	Clin Microbiol Rev	2001	11585791	No
1640	2525	1262.5	96.07	48.0	Saliency, switching, attention and control: a network model of insula function.	Vinod Menon, Lucina Q Uddin	Brain Struct Funct	2010	20512370	No
1641	1262	1262.0	32.96	33.0	Neuronal synchrony: a versatile code for the definition of relations?	W Singer	Neuron	1999	10677026	No
1642	3783	1261.0	90.34	30.1	NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.	S Ghosh, M J May, E B Kopp	Annu Rev Immunol	1998	9597130	No
1643	1261	1261.0	0.0	0.0	The recurrence of intracranial meningiomas after surgical treatment.	D SIMPSON	J Neurol Neurosurg Psychiatry	1957	13406590	Yes
1644	1260	1260.0	36.1	36.1	Stress and hippocampal plasticity.	B S McEwen	Annu Rev Neurosci	1999	10202533	No
1645	1260	1260.0	0.0	0.0	Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal.	S COHEN	J Biol Chem	1962	13880319	Yes
1646	2520	1260.0	0.0	0.0	A "DIRECT-COLORING" THIOCHOLINE METHOD FOR CHOLINESTERASES.	M J KARNOVSKY, L ROOTS	J Histochem Cytochem	1964	14187330	Yes
1647	1260	1260.0	40.88	40.9	Leishmaniasis: current situation and new perspectives.	P Desjeux	Comp Immunol Microbiol Infect Dis	2004	15225981	No
1648	1260	1260.0	33.88	33.9	The failing heart--an engine out of fuel.	Stefan Neubauer	N Engl J Med	2007	17360992	No
1649	2518	1259.0	110.75	55.4	Regulation of microRNA biogenesis.	Minju Ha, V Narry Kim	Nat Rev Mol Cell Biol	2014	25027649	No
1650	3776	1258.7	86.64	28.9	TOR signaling in growth and metabolism.	Stephan Wullschleger, Robbie Loewith, Michael N Hall	Cell	2006	16469695	No
1651	2516	1258.0	0.0	0.0	Prediction of the secondary structure of proteins from their amino acid sequence.	P Y Chou, G D Fasman	Adv Enzymol Relat Areas Mol Biol	1978	364941	No
1652	6288	1257.6	287.29	57.5	UCHIME improves sensitivity and speed of chimera detection.	Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob Knight	Bioinformatics	2011	21700674	Yes
1653	3772	1257.3	117.59	39.2	Optimization by simulated annealing.	S Kirkpatrick, C D Gelatt, M P Vecchi	Science	1983	17813860	Yes
1654	1257	1257.0	43.34	43.3	The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function.	R R Llinás	Science	1988	3059497	No
1655	3771	1257.0	116.21	38.7	The fusiform face area: a module in human extrastriate cortex specialized for face perception.	N Kanwisher, J McDermott, M M Chun	J Neurosci	1997	9151747	Yes
1656	2514	1257.0	63.63	31.8	How matrix metalloproteinases regulate cell behavior.	M D Sternlicht, Z Werb	Annu Rev Cell Dev Biol	2001	11687497	No
1657	1257	1257.0	0.0	0.0	The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations.	W W CLELAND	Biochim Biophys Acta	1963	14021667	Yes
1658	1256	1256.0	79.47	79.5	Deep learning in neural networks: an overview.	Jürgen Schmidhuber	Neural Netw	2015	25462637	No
1659	2511	1255.5	118.89	59.4	The mini-mental state examination: a comprehensive review.	T N Tombaugh, N J McIntyre	J Am Geriatr Soc	1992	1512391	No
1660	2510	1255.0	0.0	0.0	The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites.	J Shine, L Dalgarno	Proc Natl Acad Sci U S A	1974	4598299	Yes
1661	2510	1255.0	56.51	28.3	Chemokines: a new classification system and their role in immunity.	A Zlotnik, O Yoshie	Immunity	2000	10714678	No
1662	1255	1255.0	33.01	33.0	Origin, biogenesis, and activity of plant microRNAs.	Olivier Voinnet	Cell	2009	19239888	No
1663	8782	1254.6	196.88	28.1	Embryonic stem cell lines derived from human blastocysts.	J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M Jones	Science	1998	9804556	Yes
1664	1254	1254.0	0.0	0.0	The influence of some cations on an adenosine triphosphatase from peripheral nerves.	J C SKOU	Biochim Biophys Acta	1957	13412736	Yes
1665	2508	1254.0	66.39	33.2	Unravelling the pathogenesis of inflammatory bowel disease.	R J Xavier, D K Podolsky	Nature	2007	17653185	No
1666	1253	1253.0	33.34	33.3	NADPH oxidase: an update.	B M Babior	Blood	1999	10029572	No
1667	1253	1253.0	36.38	36.4	External validity of randomised controlled trials: "to whom do the results of this trial apply?".	Peter M Rothwell	Lancet	2005	15639683	Yes
1668	1252	1252.0	71.69	71.7	The biology and function of fibroblasts in cancer.	Raghu Kalluri	Nat Rev Cancer	2016	27550820	No
1669	5006	1251.5	306.63	76.7	Prevalence of childhood and adult obesity in the United States, 2011-2012.	Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M Flegal	JAMA	2014	24570244	Yes
1670	1251	1251.0	0.0	0.0	Synaptic density in human frontal cortex - developmental changes and effects of aging.	P R Huttenlocher	Brain Res	1979	427544	Yes
1671	1251	1251.0	29.75	29.8	How eukaryotic transcriptional activators work.	M Ptashne	Nature	1988	3050531	No
1672	2502	1251.0	78.81	39.4	Diarrheagenic Escherichia coli.	J P Nataro, J B Kaper	Clin Microbiol Rev	1998	9457432	No
1673	3751	1250.3	147.0	49.0	Phylogenetic identification and in situ detection of individual microbial cells without cultivation.	R I Amann, W Ludwig, K H Schleifer	Microbiol Rev	1995	7535888	No
1674	1250	1250.0	40.5	40.5	The pathophysiology of tumor necrosis factors.	P Vassalli	Annu Rev Immunol	1992	1590993	No
1675	1250	1250.0	51.14	51.1	Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue').	M N Marsh	Gastroenterology	1992	1727768	No
1676	2500	1250.0	54.68	27.3	Development by self-digestion: molecular mechanisms and biological functions of autophagy.	Beth Levine, Daniel J Klionsky	Dev Cell	2004	15068787	No
1677	1250	1250.0	46.37	46.4	Social relationships and health.	Sheldon Cohen	Am Psychol	2004	15554821	No
1678	7498	1249.7	337.57	56.3	Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.	L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R Tannenbaum	Anal Biochem	1982	7181105	Yes
1679	2498	1249.0	66.74	33.4	Steatohepatitis: a tale of two "hits"?	C P Day, O F James	Gastroenterology	1998	9547102	No
1680	2497	1248.5	73.08	36.5	Materials for electrochemical capacitors.	Patrice Simon, Yury Gogotsi	Nat Mater	2008	18956000	Yes
1681	2497	1248.5	119.21	59.6	Deciphering key features in protein structures with the new ENDscript server.	Xavier Robert, Patrice Gouet	Nucleic Acids Res	2014	24753421	Yes
1682	1248	1248.0	26.31	26.3	Macromolecular crowding: obvious but underappreciated.	R J Ellis	Trends Biochem Sci	2001	11590012	No
1683	1248	1248.0	29.18	29.2	A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other.	Dale R Nyholt	Am J Hum Genet	2004	14997420	Yes
1684	2496	1248.0	54.38	27.2	Intrinsically unstructured proteins and their functions.	H Jane Dyson, Peter E Wright	Nat Rev Mol Cell Biol	2005	15738986	No
1685	3743	1247.7	112.23	37.4	Regularization Paths for Generalized Linear Models via Coordinate Descent.	Jerome Friedman, Trevor Hastie, Rob Tibshirani	J Stat Softw	2010	20808728	Yes
1686	1247	1247.0	31.16	31.2	Neurotrophin-regulated signalling pathways.	Louis F Reichardt	Philos Trans R Soc Lond B Biol Sci	2006	16939974	No
1687	4987	1246.8	135.97	34.0	Most mammalian mRNAs are conserved targets of microRNAs.	Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel	Genome Res	2009	18955434	Yes
1688	1246	1246.0	50.81	50.8	Number of people with glaucoma worldwide.	H A Quigley	Br J Ophthalmol	1996	8695555	No
1689	1246	1246.0	28.55	28.6	Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.	S S Ferguson	Pharmacol Rev	2001	11171937	No
1690	2491	1245.5	58.71	29.4	Microtubules as a target for anticancer drugs.	Mary Ann Jordan, Leslie Wilson	Nat Rev Cancer	2004	15057285	No
1691	3733	1244.3	85.63	28.5	Toll-like receptors.	Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira	Annu Rev Immunol	2003	12524386	No
1692	1244	1244.0	34.72	34.7	The amygdala modulates the consolidation of memories of emotionally arousing experiences.	James L McGaugh	Annu Rev Neurosci	2004	15217324	No
1693	1244	1244.0	0.0	0.0	Cognitive maps in rats and men.	E C TOLMAN	Psychol Rev	1948	18870876	Yes
1694	1243	1243.0	0.0	0.0	Influences of glucose loading and of injected insulin on hepatic glucose output.	R STEELE	Ann N Y Acad Sci	1959	13833973	Yes
1695	3728	1242.7	170.16	56.7	Molecular mechanisms of epithelial-mesenchymal transition.	Samy Lamouille, Jian Xu, Rik Derynck	Nat Rev Mol Cell Biol	2014	24556840	No
1696	2485	1242.5	76.51	38.3	Lipid rafts as a membrane-organizing principle.	Daniel Lingwood, Kai Simons	Science	2010	20044567	No
1697	3727	1242.3	104.35	34.8	Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system.	B Fischl, M I Sereno, A M Dale	Neuroimage	1999	9931269	Yes
1698	2484	1242.0	0.0	0.0	A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms.	J A Horne, O Ostberg	Int J Chronobiol	1976	1027738	Yes
1699	1242	1242.0	43.26	43.3	Stress signalling pathways that impair prefrontal cortex structure and function.	Amy F T Arnsten	Nat Rev Neurosci	2009	19455173	No
1700	1241	1241.0	0.0	0.0	Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat.	C A Barnes	J Comp Physiol Psychol	1979	221551	Yes
1701	1241	1241.0	37.39	37.4	Molecular biology of prion diseases.	S B Prusiner	Science	1991	1675487	No
1702	2481	1240.5	119.63	59.8	Assessment of eating disorders: interview or self-report questionnaire?	C G Fairburn, S J Beglin	Int J Eat Disord	1994	7866415	Yes
1703	1240	1240.0	81.53	81.5	Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control.	F E Zajac	Crit Rev Biomed Eng	1989	2676342	No
1704	1240	1240.0	32.79	32.8	The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting.	H Maeda	Adv Enzyme Regul	2001	11384745	No
1705	1239	1239.0	0.0	0.0	The etiology of chondromalacia patellae.	R E OUTERBRIDGE	J Bone Joint Surg Br	1961	14038135	Yes
1706	1239	1239.0	87.41	87.4	The antibiotic resistance crisis: part 1: causes and threats.	C Lee Ventola	P T	2015	25859123	Yes
1707	4955	1238.8	252.14	63.0	An inventory for measuring clinical anxiety: psychometric properties.	A T Beck, N Epstein, G Brown, R A Steer	J Consult Clin Psychol	1988	3204199	Yes
1708	2477	1238.5	69.03	34.5	Macrophage diversity enhances tumor progression and metastasis.	Bin-Zhi Qian, Jeffrey W Pollard	Cell	2010	20371344	No
1709	1238	1238.0	0.0	0.0	TRANSFORMATION OF BIOCHEMICALLY DEFICIENT STRAINS OF BACILLUS SUBTILIS BY DEOXYRIBONUCLEATE.	J Spizizen	Proc Natl Acad Sci U S A	1958	16590310	Yes
1710	4950	1237.5	0.0	0.0	Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.	E A Jaffe, R L Nachman, C G Becker, C R Minick	J Clin Invest	1973	4355998	Yes
1711	2475	1237.5	53.43	26.7	Mutations affecting segment number and polarity in Drosophila.	C Nüsslein-Volhard, E Wieschaus	Nature	1980	6776413	Yes
1712	1237	1237.0	76.25	76.2	The structure and properties of the sense of coherence scale.	A Antonovsky	Soc Sci Med	1993	8480217	Yes
1713	4942	1235.5	130.75	32.7	The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling.	Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten Schwede	Bioinformatics	2006	16301204	Yes
1714	1235	1235.0	42.55	42.5	Interleukin-6: an overview.	J Van Snick	Annu Rev Immunol	1990	2188664	No
1715	1235	1235.0	0.0	0.0	The genetical evolution of social behaviour. II.	W D Hamilton	J Theor Biol	1964	5875340	Yes
1716	2466	1233.0	0.0	0.0	The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat.	J O'Keefe, J Dostrovsky	Brain Res	1971	5124915	Yes
1717	2466	1233.0	87.59	43.8	From best evidence to best practice: effective implementation of change in patients' care.	Richard Grol, Jeremy Grimshaw	Lancet	2003	14568747	No
1718	1232	1232.0	47.53	47.5	The polyvagal perspective.	Stephen W Porges	Biol Psychol	2007	17049418	No
1719	4927	1231.8	0.0	0.0	A rating scale for mania: reliability, validity and sensitivity.	R C Young, J T Biggs, V E Ziegler, D A Meyer	Br J Psychiatry	1978	728692	Yes
1720	2463	1231.5	53.09	26.5	A guided tour into subcellular colocalization analysis in light microscopy.	S Bolte, F P Cordelières	J Microsc	2006	17210054	Yes
1721	8617	1231.0	437.88	62.6	limma powers differential expression analyses for RNA-sequencing and microarray studies.	Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth	Nucleic Acids Res	2015	25605792	Yes
1722	2461	1230.5	60.67	30.3	NF-kappaB: a key role in inflammatory diseases.	P P Tak, G S Firestein	J Clin Invest	2001	11134171	No
1723	1230	1230.0	0.0	0.0	Determination of free amino groups in proteins by trinitrobenzenesulfonic acid.	A F Habeeb	Anal Biochem	1966	4161471	Yes
1724	1230	1230.0	64.53	64.5	Cell damage in the brain: a speculative synthesis.	B K Siesjö	J Cereb Blood Flow Metab	1981	6276420	No
1725	1230	1230.0	28.64	28.6	Critical period plasticity in local cortical circuits.	Takao K Hensch	Nat Rev Neurosci	2005	16261181	No
1726	2460	1230.0	79.83	39.9	Protective and pathogenic functions of macrophage subsets.	Peter J Murray, Thomas A Wynn	Nat Rev Immunol	2011	21997792	No
1727	1229	1229.0	62.28	62.3	Responses to depression and their effects on the duration of depressive episodes.	S Nolen-Hoeksema	J Abnorm Psychol	1991	1757671	No
1728	1228	1228.0	27.98	28.0	The ubiquitin-proteasome proteolytic pathway.	A Ciechanover	Cell	1994	7923371	No
1729	1228	1228.0	42.76	42.8	Strong localization of photons in certain disordered dielectric superlattices.	John	Phys Rev Lett	1987	10034761	Yes
1730	1228	1228.0	49.11	49.1	Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies.	Peter C Austin	Pharm Stat	2011	20925139	Yes
1731	1227	1227.0	51.08	51.1	Dual-task interference in simple tasks: data and theory.	H Pashler	Psychol Bull	1994	7972591	No
1732	1227	1227.0	33.21	33.2	The proto-oncogene Bcl-2 and its role in regulating apoptosis.	G Kroemer	Nat Med	1997	9176486	No
1733	1227	1227.0	36.46	36.5	Hydrogels for biomedical applications.	Allan S Hoffman	Adv Drug Deliv Rev	2002	11755703	No
1734	2454	1227.0	69.51	34.8	Obesity.	David W Haslam, W Philip T James	Lancet	2005	16198769	No
1735	1227	1227.0	65.48	65.5	What's in a name? Qualitative description revisited.	Margarete Sandelowski	Res Nurs Health	2010	20014004	Yes
1736	1226	1226.0	32.98	33.0	Oxidative stress in Parkinson's disease.	Peter Jenner	Ann Neurol	2003	12666096	No
1737	1226	1226.0	0.0	0.0	METHOD FOR ASSAY OF INTESTINAL DISACCHARIDASES.	A DAHLQVIST	Anal Biochem	1964	14106916	Yes
1738	6129	1225.8	0.0	0.0	STUDIES OF ILLNESS IN THE AGED. THE INDEX OF ADL: A STANDARDIZED MEASURE OF BIOLOGICAL AND PSYCHOSOCIAL FUNCTION.	S KATZ, A B FORD, R W MOSKOWITZ, B A JACKSON, M W JAFFE	JAMA	1963	14044222	Yes
1739	4900	1225.0	228.03	57.0	Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.	David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman	Int J Surg	2010	20171303	No
1740	2449	1224.5	64.34	32.2	A novel multigene family may encode odorant receptors: a molecular basis for odor recognition.	L Buck, R Axel	Cell	1991	1840504	Yes
1741	2449	1224.5	75.24	37.6	Early identification of refractory epilepsy.	P Kwan, M J Brodie	N Engl J Med	2000	10660394	Yes
1742	1224	1224.0	37.24	37.2	Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp.	D A Dougherty	Science	1996	8539615	No
1743	1224	1224.0	75.81	75.8	Chronic illness as biographical disruption.	M Bury	Sociol Health Illn	1982	10260456	Yes
1744	3671	1223.7	95.79	31.9	Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies.	Daniel Falush, Matthew Stephens, Jonathan K Pritchard	Genetics	2003	12930761	Yes
1745	1221	1221.0	46.61	46.6	Evidence for a central component of post-injury pain hypersensitivity.	C J Woolf	Nature	1983	6656869	Yes
1746	2441	1220.5	91.27	45.6	Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics.	G R Gibson, M B Roberfroid	J Nutr	1995	7782892	No
1747	2441	1220.5	77.65	38.8	Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper.	B R Celli, W MacNee	Eur Respir J	2004	15219010	No
1748	1220	1220.0	46.98	47.0	Extracellular ATP: effects, sources and fate.	J L Gordon	Biochem J	1986	3006665	No
1749	1219	1219.0	0.0	0.0	Disconnexion syndromes in animals and man. I.	N Geschwind	Brain	1965	5318481	No
1750	2438	1219.0	84.28	42.1	Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being.	James J Gross, Oliver P John	J Pers Soc Psychol	2003	12916575	Yes
1751	1219	1219.0	0.0	0.0	Structural considerations in the interaction of DNA and acridines.	L S LERMAN	J Mol Biol	1961	13761054	Yes
1752	3654	1218.0	88.02	29.3	Osteoclast differentiation and activation.	William J Boyle, W Scott Simonet, David L Lacey	Nature	2003	12748652	No
1753	1218	1218.0	47.78	47.8	Functional and effective connectivity: a review.	Karl J Friston	Brain Connect	2011	22432952	No
1754	1217	1217.0	62.87	62.9	Sample size in qualitative research.	M Sandelowski	Res Nurs Health	1995	7899572	Yes
1755	2434	1217.0	61.22	30.6	A comparison of bayesian methods for haplotype reconstruction from population genotype data.	Matthew Stephens, Peter Donnelly	Am J Hum Genet	2003	14574645	Yes
1756	2433	1216.5	76.83	38.4	miRBase: integrating microRNA annotation and deep-sequencing data.	Ana Kozomara, Sam Griffiths-Jones	Nucleic Acids Res	2011	21037258	Yes
1757	1216	1216.0	23.05	23.1	The DNA methyltransferases of mammals.	T H Bestor	Hum Mol Genet	2000	11005794	No
1758	10941	1215.7	393.61	43.7	The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10.	D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C Dunbar	J Clin Psychiatry	1998	9881538	No
1759	2429	1214.5	80.89	40.4	A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes.	S Tabor, C C Richardson	Proc Natl Acad Sci U S A	1985	3156376	Yes
1760	1214	1214.0	53.11	53.1	Serum albumin.	T Peters	Adv Protein Chem	1985	3904348	No
1761	1214	1214.0	29.42	29.4	Hyaluronan: from extracellular glue to pericellular cue.	Bryan P Toole	Nat Rev Cancer	2004	15229478	No
1762	7278	1213.0	206.07	34.3	Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.	D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuire	Science	1987	3798106	Yes
1763	1213	1213.0	24.02	24.0	Ubiquitin-dependent protein degradation.	M Hochstrasser	Annu Rev Genet	1996	8982460	No
1764	2425	1212.5	78.7	39.4	A perspective on cancer cell metastasis.	Christine L Chaffer, Robert A Weinberg	Science	2011	21436443	No
1765	2424	1212.0	60.51	30.3	Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.	T Miyashita, J C Reed	Cell	1995	7834749	Yes
1766	1212	1212.0	24.57	24.6	Epithelial-mesenchymal transitions in development and pathologies.	Jean Paul Thiery	Curr Opin Cell Biol	2003	14644200	No
1767	1212	1212.0	26.82	26.8	Stability and flexibility of epigenetic gene regulation in mammalian development.	Wolf Reik	Nature	2007	17522676	No
1768	1211	1211.0	28.92	28.9	Protein misfolding, evolution and disease.	C M Dobson	Trends Biochem Sci	1999	10470028	No
1769	4844	1211.0	130.3	32.6	Improved prediction of signal peptides: SignalP 3.0.	Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren Brunak	J Mol Biol	2004	15223320	Yes
1770	1208	1208.0	79.44	79.4	Conservation of resources. A new attempt at conceptualizing stress.	S E Hobfoll	Am Psychol	1989	2648906	No
1771	1208	1208.0	40.32	40.3	Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms.	J A Beavo	Physiol Rev	1995	7480160	No
1772	1207	1207.0	26.03	26.0	Altering the genome by homologous recombination.	M R Capecchi	Science	1989	2660260	No
1773	1207	1207.0	0.0	0.0	The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers.	R Ross	J Cell Biol	1971	4327464	Yes
1774	1207	1207.0	31.17	31.2	Molecular basis of long-term plasticity underlying addiction.	E J Nestler	Nat Rev Neurosci	2001	11252991	No
1775	1206	1206.0	49.71	49.7	Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson.	H J Gundersen	J Microsc	1986	3761363	Yes
1776	2412	1206.0	50.39	25.2	Wnt signalling in stem cells and cancer.	Tannishtha Reya, Hans Clevers	Nature	2005	15829953	No
1777	1206	1206.0	46.59	46.6	The global impact of pre-eclampsia and eclampsia.	Lelia Duley	Semin Perinatol	2009	19464502	No
1778	2411	1205.5	174.54	87.3	Rating systems in the evaluation of knee ligament injuries.	Y Tegner, J Lysholm	Clin Orthop Relat Res	1985	4028566	Yes
1779	3616	1205.3	109.69	36.6	TCS: a computer program to estimate gene genealogies.	M Clement, D Posada, K A Crandall	Mol Ecol	2000	11050560	Yes
1780	1205	1205.0	100.85	100.8	The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system.	F C Ewald	Clin Orthop Relat Res	1989	2805502	Yes
1781	1205	1205.0	40.63	40.6	DNA topoisomerases.	J C Wang	Annu Rev Biochem	1985	2992360	No
1782	1205	1205.0	21.87	21.9	Protein modification by SUMO.	Erica S Johnson	Annu Rev Biochem	2004	15189146	No
1783	2409	1204.5	96.06	48.0	The efficiency of systematic sampling in stereology and its prediction.	H J Gundersen, E B Jensen	J Microsc	1987	3430576	Yes
1784	1204	1204.0	0.0	0.0	Ionic blockage of sodium channels in nerve.	A M Woodhull	J Gen Physiol	1973	4541078	Yes
1785	2408	1204.0	68.7	34.4	The biology of vascular endothelial growth factor.	N Ferrara, T Davis-Smyth	Endocr Rev	1997	9034784	No
1786	1204	1204.0	32.45	32.5	The use of nanocrystals in biological detection.	Paul Alivisatos	Nat Biotechnol	2004	14704706	Yes
1787	1204	1204.0	46.92	46.9	A Social Neuroscience Perspective on Adolescent Risk-Taking.	Laurence Steinberg	Dev Rev	2008	18509515	Yes
1788	2406	1203.0	87.55	43.8	Prediction of protein antigenic determinants from amino acid sequences.	T P Hopp, K R Woods	Proc Natl Acad Sci U S A	1981	6167991	Yes
1789	1203	1203.0	28.75	28.8	Mitochondria: dynamic organelles in disease, aging, and development.	David C Chan	Cell	2006	16814712	No
1790	2404	1202.0	52.55	26.3	Short-term synaptic plasticity.	Robert S Zucker, Wade G Regehr	Annu Rev Physiol	2002	11826273	No
1791	1201	1201.0	30.35	30.4	Cell signaling. H2O2, a necessary evil for cell signaling.	Sue Goo Rhee	Science	2006	16809515	Yes
1792	2401	1200.5	120.82	60.4	Avoiding false positives with PCR.	S Kwok, R Higuchi	Nature	1989	2716852	Yes
1793	2401	1200.5	49.8	24.9	Cancer genes and the pathways they control.	Bert Vogelstein, Kenneth W Kinzler	Nat Med	2004	15286780	No
1794	1200	1200.0	44.88	44.9	The biology of interleukin-6.	T Kishimoto	Blood	1989	2473791	No
1795	1200	1200.0	0.0	0.0	Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.	J M VAN ROSSUM	Arch Int Pharmacodyn Ther	1963	13996119	Yes
1796	1199	1199.0	31.76	31.8	The mitochondrial permeability transition pore and its role in cell death.	M Crompton	Biochem J	1999	10393078	No
1797	3597	1199.0	106.56	35.5	Cognitive and emotional influences in anterior cingulate cortex.	Bush, Luu, Posner	Trends Cogn Sci	2000	10827444	Yes
1798	1199	1199.0	42.46	42.5	Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research.	M Robin DiMatteo	Med Care	2004	15076819	Yes
1799	2395	1197.5	60.29	30.1	The pathophysiology and treatment of sepsis.	Richard S Hotchkiss, Irene E Karl	N Engl J Med	2003	12519925	No
1800	1197	1197.0	66.96	67.0	The contribution of low birth weight to infant mortality and childhood morbidity.	M C McCormick	N Engl J Med	1985	3880598	No
1801	1197	1197.0	37.65	37.6	Graphene transistors.	Frank Schwierz	Nat Nanotechnol	2010	20512128	Yes
1802	1196	1196.0	46.87	46.9	Polycystic ovary syndrome.	S Franks	N Engl J Med	1995	7651477	No
1803	2392	1196.0	85.89	42.9	The pathogenesis of rheumatoid arthritis.	Iain B McInnes, Georg Schett	N Engl J Med	2011	22150039	No
1804	4781	1195.2	0.0	0.0	The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care.	S P Baker, B O'Neill, W Haddon, W B Long	J Trauma	1974	4814394	Yes
1805	2389	1194.5	71.05	35.5	Molecular mechanisms of long noncoding RNAs.	Kevin C Wang, Howard Y Chang	Mol Cell	2011	21925379	No
1806	1194	1194.0	0.0	0.0	Dynamic properties of mammalian skeletal muscles.	R I Close	Physiol Rev	1972	4256989	No
1807	1194	1194.0	38.77	38.8	A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology.	J Engel	Epilepsia	2001	11422340	Yes
1808	1194	1194.0	22.71	22.7	Chromatin modification and epigenetic reprogramming in mammalian development.	En Li	Nat Rev Genet	2002	12209141	No
1809	1194	1194.0	0.0	0.0	Discharge patterns and functional organization of mammalian retina.	S W KUFFLER	J Neurophysiol	1953	13035466	Yes
1810	1194	1194.0	36.88	36.9	Bioactive microbial metabolites.	János Bérdy	J Antibiot (Tokyo)	2005	15813176	No
1811	1194	1194.0	38.21	38.2	The debate over dopamine's role in reward: the case for incentive salience.	Kent C Berridge	Psychopharmacology (Berl)	2007	17072591	No
1812	2387	1193.5	65.6	32.8	Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress.	H Cai, D G Harrison	Circ Res	2000	11073878	No
1813	1193	1193.0	31.54	31.5	PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.	B M Spiegelman	Diabetes	1998	9568680	No
1814	2386	1193.0	54.99	27.5	Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry.	Joshua E Elias, Steven P Gygi	Nat Methods	2007	17327847	Yes
1815	1193	1193.0	27.78	27.8	Autophagy: from phenomenology to molecular understanding in less than a decade.	Daniel J Klionsky	Nat Rev Mol Cell Biol	2007	17712358	No
1816	1193	1193.0	26.2	26.2	Maintenance of C. elegans.	Theresa Stiernagle	WormBook	2006	18050451	No
1817	3579	1193.0	112.7	37.6	I-TASSER: a unified platform for automated protein structure and function prediction.	Ambrish Roy, Alper Kucukural, Yang Zhang	Nat Protoc	2010	20360767	Yes
1818	5962	1192.4	157.93	31.6	Site-directed mutagenesis by overlap extension using the polymerase chain reaction.	S N Ho, H D Hunt, R M Horton, J K Pullen, L R Pease	Gene	1989	2744487	Yes
1819	2384	1192.0	0.0	0.0	Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans.	D H Figurski, D R Helinski	Proc Natl Acad Sci U S A	1979	377280	Yes
1820	1192	1192.0	38.52	38.5	Trophic factors and neuronal survival.	Y A Barde	Neuron	1989	2697237	No
1821	1192	1192.0	37.11	37.1	A note on robust variance estimation for cluster-correlated data.	R L Williams	Biometrics	2000	10877330	Yes
1822	2384	1192.0	56.87	28.4	Self-assembly at all scales.	George M Whitesides, Bartosz Grzybowski	Science	2002	11923529	Yes
1823	2384	1192.0	79.38	39.7	Astrocytes: biology and pathology.	Michael V Sofroniew, Harry V Vinters	Acta Neuropathol	2010	20012068	No
1824	1191	1191.0	0.0	0.0	Interhemispheric differences in the localization of psychological processes in man.	B Milner	Br Med Bull	1971	4937273	No
1825	1191	1191.0	43.21	43.2	The functional gastrointestinal disorders and the Rome III process.	Douglas A Drossman	Gastroenterology	2006	16678553	No
1826	1190	1190.0	36.46	36.5	The epidemiology of venous thromboembolism.	Richard H White	Circulation	2003	12814979	No
1827	1190	1190.0	33.76	33.8	Interoception: the sense of the physiological condition of the body.	A D Craig	Curr Opin Neurobiol	2003	12965300	No
1828	1189	1189.0	45.43	45.4	Gene flow and the geographic structure of natural populations.	M Slatkin	Science	1987	3576198	Yes
1829	2378	1189.0	105.98	53.0	The Oswestry Disability Index.	J C Fairbank, P B Pynsent	Spine (Phila Pa 1976)	2000	11074683	No
1830	2376	1188.0	122.98	61.5	Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use.	A Y Finlay, G K Khan	Clin Exp Dermatol	1994	8033378	Yes
1831	1188	1188.0	22.33	22.3	The snail superfamily of zinc-finger transcription factors.	M Angela Nieto	Nat Rev Mol Cell Biol	2002	11994736	No
1832	1188	1188.0	38.92	38.9	Understanding organofluorine chemistry. An introduction to the C-F bond.	David O'Hagan	Chem Soc Rev	2008	18197347	No
1833	2374	1187.0	57.14	28.6	Inhibitors of mammalian G1 cyclin-dependent kinases.	C J Sherr, J M Roberts	Genes Dev	1995	7758941	No
1834	1186	1186.0	32.5	32.5	A molecular view of microbial diversity and the biosphere.	N R Pace	Science	1997	9115194	No
1835	1186	1186.0	30.6	30.6	Upconversion and anti-Stokes processes with f and d ions in solids.	François Auzel	Chem Rev	2004	14719973	Yes
1836	2371	1185.5	76.55	38.3	Bronchopulmonary dysplasia.	A H Jobe, E Bancalari	Am J Respir Crit Care Med	2001	11401896	No
1837	1185	1185.0	0.0	0.0	Mate selection-a selection for a handicap.	A Zahavi	J Theor Biol	1975	1195756	Yes
1838	1185	1185.0	27.38	27.4	Drug discovery: a historical perspective.	J Drews	Science	2000	10720314	No
1839	7108	1184.7	271.55	45.3	TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions.	Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg	Genome Biol	2013	23618408	Yes
1840	2368	1184.0	53.87	26.9	The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.	M S Brown, J L Goldstein	Cell	1997	9150132	No
1841	4733	1183.2	113.09	28.3	Probability-based protein identification by searching sequence databases using mass spectrometry data.	D N Perkins, D J Pappin, D M Creasy, J S Cottrell	Electrophoresis	1999	10612281	Yes
1842	2366	1183.0	86.35	43.2	Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction.	K B Mullis, F A Faloona	Methods Enzymol	1987	3431465	Yes
1843	1183	1183.0	33.18	33.2	Two pathogenetic types of endometrial carcinoma.	J V Bokhman	Gynecol Oncol	1983	6822361	Yes
1844	3548	1182.7	0.0	0.0	Research diagnostic criteria: rationale and reliability.	R L Spitzer, J Endicott, E Robins	Arch Gen Psychiatry	1978	655775	Yes
1845	2365	1182.5	91.48	45.7	A rapid boiling method for the preparation of bacterial plasmids.	D S Holmes, M Quigley	Anal Biochem	1981	6269464	Yes
1846	2364	1182.0	169.32	84.7	Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees.	Ivica Letunic, Peer Bork	Nucleic Acids Res	2016	27095192	Yes
1847	1181	1181.0	40.91	40.9	DNA topoisomerase poisons as antitumor drugs.	L F Liu	Annu Rev Biochem	1989	2549853	No
1848	1181	1181.0	46.86	46.9	History of the Rochester Epidemiology Project.	L J Melton	Mayo Clin Proc	1996	8594285	No
1849	1181	1181.0	35.41	35.4	The importance of the ratio of omega-6/omega-3 essential fatty acids.	A P Simopoulos	Biomed Pharmacother	2002	12442909	No
1850	1181	1181.0	40.04	40.0	Recent developments in isocyanide based multicomponent reactions in applied chemistry.	Alexander Dömling	Chem Rev	2006	16402771	No
1851	1181	1181.0	45.32	45.3	Formation of glasses from liquids and biopolymers.	C A Angell	Science	1995	17770101	Yes
1852	1180	1180.0	42.24	42.2	Ionic dependence of glutamate neurotoxicity.	D W Choi	J Neurosci	1987	2880938	Yes
1853	1180	1180.0	42.44	42.4	Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance.	L Bravo	Nutr Rev	1998	9838798	No
1854	1180	1180.0	25.91	25.9	Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators.	R I Morimoto	Genes Dev	1998	9869631	No
1855	2360	1180.0	56.23	28.1	NMR View: A computer program for the visualization and analysis of NMR data.	B A Johnson, R A Blevins	J Biomol NMR	1994	22911360	Yes
1856	4718	1179.5	0.0	0.0	Antibiotic susceptibility testing by a standardized single disk method.	A W Bauer, W M Kirby, J C Sherris, M Turck	Am J Clin Pathol	1966	5325707	Yes
1857	2359	1179.5	86.27	43.1	A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.	J Messing, J Vieira	Gene	1982	6295880	Yes
1858	2359	1179.5	95.95	48.0	Measuring emotion: the Self-Assessment Manikin and the Semantic Differential.	M M Bradley, P J Lang	J Behav Ther Exp Psychiatry	1994	7962581	Yes
1859	2359	1179.5	83.71	41.9	Biochemistry of multidrug resistance mediated by the multidrug transporter.	M M Gottesman, I Pastan	Annu Rev Biochem	1993	8102521	No
1860	1179	1179.0	0.0	0.0	ATPase activity of myosin correlated with speed of muscle shortening.	M Bárány	J Gen Physiol	1967	4227924	Yes
1861	1179	1179.0	36.45	36.5	Synergy, antagonism, and what the chequerboard puts between them.	F C Odds	J Antimicrob Chemother	2003	12805255	No
1862	1179	1179.0	31.32	31.3	Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study).	K M Fox	Lancet	2003	13678872	Yes
1863	1179	1179.0	111.3	111.3	Minimap2: pairwise alignment for nucleotide sequences.	Heng Li	Bioinformatics	2018	29750242	Yes
1864	1178	1178.0	45.93	45.9	The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat.	L W Swanson	Brain Res Bull	1982	6816390	Yes
1865	1178	1178.0	50.67	50.7	Aging, natural death, and the compression of morbidity.	J F Fries	N Engl J Med	1980	7383070	Yes
1866	1178	1178.0	27.64	27.6	Cancer of the ovary.	Stephen A Cannistra	N Engl J Med	2004	15590954	No
1867	1178	1178.0	32.34	32.3	Marine viruses--major players in the global ecosystem.	Curtis A Suttle	Nat Rev Microbiol	2007	17853907	No
1868	1178	1178.0	46.77	46.8	Asthma phenotypes: the evolution from clinical to molecular approaches.	Sally E Wenzel	Nat Med	2012	22561835	No
1869	2353	1176.5	60.67	30.3	Long short-term memory.	S Hochreiter, J Schmidhuber	Neural Comput	1997	9377276	Yes
1870	1176	1176.0	34.25	34.2	Understanding biofilm resistance to antibacterial agents.	David Davies	Nat Rev Drug Discov	2003	12563302	No
1871	1175	1175.0	36.03	36.0	Steroid receptor regulated transcription of specific genes and gene networks.	K R Yamamoto	Annu Rev Genet	1985	3909942	No
1872	1175	1175.0	46.0	46.0	The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate.	G R Buettner	Arch Biochem Biophys	1993	8434935	No
1873	1174	1174.0	34.25	34.2	Genetic consequences of climatic oscillations in the Quaternary.	G M Hewitt	Philos Trans R Soc Lond B Biol Sci	2004	15101575	No
1874	1174	1174.0	29.97	30.0	Refined structure of the nicotinic acetylcholine receptor at 4A resolution.	Nigel Unwin	J Mol Biol	2005	15701510	Yes
1875	1174	1174.0	45.31	45.3	Matching methods for causal inference: A review and a look forward.	Elizabeth A Stuart	Stat Sci	2010	20871802	Yes
1876	1173	1173.0	0.0	0.0	Microbial ecology of the gastrointestinal tract.	D C Savage	Annu Rev Microbiol	1977	334036	No
1877	1173	1173.0	33.78	33.8	Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule.	G von Heijne	J Mol Biol	1992	1593632	Yes
1878	1173	1173.0	20.51	20.5	The economics of ribosome biosynthesis in yeast.	J R Warner	Trends Biochem Sci	1999	10542411	No
1879	2346	1173.0	44.16	22.1	Rab proteins as membrane organizers.	M Zerial, H McBride	Nat Rev Mol Cell Biol	2001	11252952	No
1880	2346	1173.0	59.3	29.6	The DNA damage response: making it safe to play with knives.	Alberto Ciccia, Stephen J Elledge	Mol Cell	2010	20965415	No
1881	2343	1171.5	64.37	32.2	Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering.	M P Lutolf, J A Hubbell	Nat Biotechnol	2005	15637621	No
1882	1171	1171.0	0.0	0.0	Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.	B Hille	J Gen Physiol	1977	300786	Yes
1883	2342	1171.0	52.8	26.4	New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites.	R D Gietz, A Sugino	Gene	1988	3073106	Yes
1884	1171	1171.0	61.16	61.2	A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability.	D J Schuirmann	J Pharmacokinet Biopharm	1987	3450848	Yes
1885	1171	1171.0	31.59	31.6	Regulation of differentiation of vascular smooth muscle cells.	G K Owens	Physiol Rev	1995	7624392	No
1886	1171	1171.0	40.16	40.2	Chlorophyll fluorescence: a probe of photosynthesis in vivo.	Neil R Baker	Annu Rev Plant Biol	2008	18444897	No
1887	1171	1171.0	42.76	42.8	Aging, cellular senescence, and cancer.	Judith Campisi	Annu Rev Physiol	2013	23140366	No
1888	2341	1170.5	62.18	31.1	Multipoint quantitative-trait linkage analysis in general pedigrees.	L Almasy, J Blangero	Am J Hum Genet	1998	9545414	Yes
1889	2341	1170.5	93.98	47.0	Genome editing. The new frontier of genome engineering with CRISPR-Cas9.	Jennifer A Doudna, Emmanuelle Charpentier	Science	2014	25430774	No
1890	2340	1170.0	54.21	27.1	LTP and LTD: an embarrassment of riches.	Robert C Malenka, Mark F Bear	Neuron	2004	15450156	No
1891	1169	1169.0	38.25	38.2	Redox signaling: nitrosylation and related target interactions of nitric oxide.	J S Stamler	Cell	1994	7923362	No
1892	2337	1168.5	59.11	29.6	An essential role for NF-kappaB in preventing TNF-alpha-induced cell death.	A A Beg, D Baltimore	Science	1996	8864118	Yes
1893	1168	1168.0	27.9	27.9	The ATP synthase--a splendid molecular machine.	P D Boyer	Annu Rev Biochem	1997	9242922	No
1894	2336	1168.0	74.93	37.5	Genome regulation by long noncoding RNAs.	John L Rinn, Howard Y Chang	Annu Rev Biochem	2012	22663078	No
1895	1167	1167.0	0.0	0.0	RNA-dependent DNA polymerase in virions of RNA tumour viruses.	D Baltimore	Nature	1970	4316300	Yes
1896	1167	1167.0	37.53	37.5	A more meaningful scoring system for determining the severity of coronary heart disease.	G G Gensini	Am J Cardiol	1983	6823874	Yes
1897	2334	1167.0	67.15	33.6	Abdominal obesity and metabolic syndrome.	Jean-Pierre Després, Isabelle Lemieux	Nature	2006	17167477	No
1898	1167	1167.0	41.59	41.6	Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations.	Chao-Jun Li	Acc Chem Res	2009	19220064	Yes
1899	2334	1167.0	70.24	35.1	Molecular replacement with MOLREP.	Alexei Vagin, Alexei Teplyakov	Acta Crystallogr D Biol Crystallogr	2010	20057045	Yes
1900	1166	1166.0	49.07	49.1	The self-medication hypothesis of substance use disorders: a reconsideration and recent applications.	E J Khantzian	Harv Rev Psychiatry	1997	9385000	No
1901	2332	1166.0	47.7	23.9	Autophagy as a regulated pathway of cellular degradation.	D J Klionsky, S D Emr	Science	2000	11099404	No
1902	3496	1165.3	0.0	0.0	A rapid method for the isolation of functional thymus-derived murine lymphocytes.	M H Julius, E Simpson, L A Herzenberg	Eur J Immunol	1973	4587740	Yes
1903	1164	1164.0	63.02	63.0	Neurogenetic adaptive mechanisms in alcoholism.	C R Cloninger	Science	1987	2882604	Yes
1904	2328	1164.0	0.0	0.0	Computed circular dichroism spectra for the evaluation of protein conformation.	N Greenfield, G D Fasman	Biochemistry	1969	5346390	Yes
1905	1164	1164.0	34.29	34.3	Hemispheric asymmetry reduction in older adults: the HAROLD model.	Roberto Cabeza	Psychol Aging	2002	11931290	No
1906	1164	1164.0	32.1	32.1	Drug-induced prolongation of the QT interval.	Dan M Roden	N Engl J Med	2004	14999113	No
1907	2328	1164.0	62.59	31.3	Powering the planet: chemical challenges in solar energy utilization.	Nathan S Lewis, Daniel G Nocera	Proc Natl Acad Sci U S A	2006	17043226	Yes
1908	2328	1164.0	68.82	34.4	Regulation of chromatin by histone modifications.	Andrew J Bannister, Tony Kouzarides	Cell Res	2011	21321607	No
1909	1163	1163.0	0.0	0.0	Application of a microtechnique to viral serological investigations.	J L SEVER	J Immunol	1962	13910995	Yes
1910	2326	1163.0	69.21	34.6	The gut microbiota shapes intestinal immune responses during health and disease.	June L Round, Sarkis K Mazmanian	Nat Rev Immunol	2009	19343057	No
1911	2325	1162.5	87.96	44.0	Performing the exact test of Hardy-Weinberg proportion for multiple alleles.	S W Guo, E A Thompson	Biometrics	1992	1637966	Yes
1912	2325	1162.5	82.2	41.1	Porosity of 3D biomaterial scaffolds and osteogenesis.	Vassilis Karageorgiou, David Kaplan	Biomaterials	2005	15860204	No
1913	2325	1162.5	55.09	27.5	Cellular senescence: when bad things happen to good cells.	Judith Campisi, Fabrizio d'Adda di Fagagna	Nat Rev Mol Cell Biol	2007	17667954	No
1914	1162	1162.0	56.24	56.2	KDIGO clinical practice guidelines for acute kidney injury.	Arif Khwaja	Nephron Clin Pract	2012	22890468	No
1915	2323	1161.5	74.89	37.4	CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure.	Mattias Jakobsson, Noah A Rosenberg	Bioinformatics	2007	17485429	Yes
1916	4645	1161.2	216.95	54.2	Bayesian phylogenetics with BEAUti and the BEAST 1.7.	Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew Rambaut	Mol Biol Evol	2012	22367748	Yes
1917	2322	1161.0	0.0	0.0	A scaled version of the General Health Questionnaire.	D P Goldberg, V F Hillier	Psychol Med	1979	424481	Yes
1918	1161	1161.0	44.49	44.5	G proteins and dual control of adenylate cyclase.	A G Gilman	Cell	1984	6321035	Yes
1919	1161	1161.0	58.78	58.8	Whatever next? Predictive brains, situated agents, and the future of cognitive science.	Andy Clark	Behav Brain Sci	2013	23663408	No
1920	2321	1160.5	86.19	43.1	Functional architecture of basal ganglia circuits: neural substrates of parallel processing.	G E Alexander, M D Crutcher	Trends Neurosci	1990	1695401	No
1921	1160	1160.0	32.76	32.8	Reconciling the chemistry and biology of reactive oxygen species.	Christine C Winterbourn	Nat Chem Biol	2008	18421291	No
1922	1160	1160.0	42.21	42.2	Stress and disorders of the stress system.	George P Chrousos	Nat Rev Endocrinol	2009	19488073	No
1923	2318	1159.0	0.0	0.0	The structure of coping.	L I Pearlin, C Schooler	J Health Soc Behav	1978	649936	Yes
1924	1159	1159.0	57.48	57.5	A structured interview guide for the Hamilton Depression Rating Scale.	J B Williams	Arch Gen Psychiatry	1988	3395203	Yes
1925	1159	1159.0	50.15	50.1	Frontal-subcortical circuits and human behavior.	J L Cummings	Arch Neurol	1993	8352676	No
1926	1159	1159.0	31.57	31.6	Functions of ceramide in coordinating cellular responses to stress.	Y A Hannun	Science	1996	8943189	No
1927	1159	1159.0	19.73	19.7	Cancer. Addiction to oncogenes--the Achilles heal of cancer.	I Bernard Weinstein	Science	2002	12098689	No
1928	1159	1159.0	38.68	38.7	Treatment of infections associated with surgical implants.	Rabih O Darouiche	N Engl J Med	2004	15070792	No
1929	1158	1158.0	25.88	25.9	The many faces of macrophage activation.	David M Mosser	J Leukoc Biol	2003	12554797	No
1930	1158	1158.0	42.48	42.5	The law of attrition.	Gunther Eysenbach	J Med Internet Res	2005	15829473	Yes
1931	3473	1157.7	146.19	48.7	CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting.	Teresa C Horan, Mary Andrus, Margaret A Dudeck	Am J Infect Control	2008	18538699	No
1932	1157	1157.0	28.49	28.5	Ordered porous materials for emerging applications.	Mark E Davis	Nature	2002	12075343	No
1933	2313	1156.5	52.75	26.4	Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.	J M Kyriakis, J Avruch	Physiol Rev	2001	11274345	No
1934	1156	1156.0	0.0	0.0	Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle.	A Fleckenstein	Annu Rev Pharmacol Toxicol	1977	326161	No
1935	1156	1156.0	53.46	53.5	Cognitive reserve in ageing and Alzheimer's disease.	Yaakov Stern	Lancet Neurol	2012	23079557	No
1936	2311	1155.5	0.0	0.0	The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent.	A E Bolton, W M Hunter	Biochem J	1973	4733239	Yes
1937	2310	1155.0	68.71	34.4	The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.	P Angel, M Karin	Biochim Biophys Acta	1991	1751545	No
1938	1155	1155.0	0.0	0.0	Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection.	W H Oldendorf	Am J Physiol	1971	5124307	Yes
1939	1155	1155.0	40.69	40.7	Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum.	A Fabiato	Am J Physiol	1983	6346892	No
1940	2309	1154.5	98.14	49.1	Thermodynamics of protein association reactions: forces contributing to stability.	P D Ross, S Subramanian	Biochemistry	1981	7248271	Yes
1941	1154	1154.0	37.21	37.2	Capacitative calcium entry revisited.	J W Putney	Cell Calcium	1990	1965707	No
1942	2308	1154.0	62.0	31.0	NF-kappa B: ten years after.	P A Baeuerle, D Baltimore	Cell	1996	8858144	No
1943	3462	1154.0	76.41	25.5	The versatility and universality of calcium signalling.	M J Berridge, P Lipp, M D Bootman	Nat Rev Mol Cell Biol	2000	11413485	No
1944	2308	1154.0	64.2	32.1	A globally coherent fingerprint of climate change impacts across natural systems.	Camille Parmesan, Gary Yohe	Nature	2003	12511946	Yes
1945	1154	1154.0	21.68	21.7	SUMO: a history of modification.	Ronald T Hay	Mol Cell	2005	15808504	No
1946	1154	1154.0	48.28	48.3	Phase retrieval algorithms: a comparison.	J R Fienup	Appl Opt	1982	20396114	Yes
1947	2307	1153.5	0.0	0.0	New Giemsa method for the differential staining of sister chromatids.	P Perry, S Wolff	Nature	1974	4138930	Yes
1948	1153	1153.0	22.13	22.1	Regulatory T cells: key controllers of immunologic self-tolerance.	S Sakaguchi	Cell	2000	10850488	No
1949	1152	1152.0	51.27	51.3	Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes.	C E Mogensen	N Engl J Med	1984	6690964	Yes
1950	3456	1152.0	104.53	34.8	How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.	R M Sapolsky, L M Romero, A U Munck	Endocr Rev	2000	10696570	No
1951	1152	1152.0	24.88	24.9	Natively unfolded proteins: a point where biology waits for physics.	Vladimir N Uversky	Protein Sci	2002	11910019	No
1952	1152	1152.0	0.0	0.0	CHROMATOGRAPHIC SEPARATION OF HUMAN BRAIN GANGLIOSIDES.	L SVENNERHOLM	J Neurochem	1963	14066623	Yes
1953	1152	1152.0	0.0	0.0	Application of a Theory of Enzyme Specificity to Protein Synthesis.	D E Koshland	Proc Natl Acad Sci U S A	1958	16590179	Yes
1954	2303	1151.5	112.38	56.2	Natural products as sources of new drugs over the 30 years from 1981 to 2010.	David J Newman, Gordon M Cragg	J Nat Prod	2012	22316239	No
1955	1151	1151.0	23.6	23.6	Protein kinases--the major drug targets of the twenty-first century?	Philip Cohen	Nat Rev Drug Discov	2002	12120282	No
1956	3451	1150.3	135.42	45.1	Global estimates of the prevalence of diabetes for 2010 and 2030.	J E Shaw, R A Sicree, P Z Zimmet	Diabetes Res Clin Pract	2010	19896746	Yes
1957	1150	1150.0	28.09	28.1	Mechanisms of foxp3+ T regulatory cell-mediated suppression.	Ethan M Shevach	Immunity	2009	19464986	No
1958	2299	1149.5	76.67	38.3	The cortical organization of speech processing.	Gregory Hickok, David Poeppel	Nat Rev Neurosci	2007	17431404	No
1959	1149	1149.0	37.49	37.5	Molecular bases of the acute coronary syndromes.	P Libby	Circulation	1995	7758192	No
1960	1149	1149.0	30.71	30.7	The blood-brain barrier: bottleneck in brain drug development.	William M Pardridge	NeuroRx	2005	15717053	No
1961	2298	1149.0	63.69	31.8	Cell signaling by receptor tyrosine kinases.	Mark A Lemmon, Joseph Schlessinger	Cell	2010	20602996	No
1962	2297	1148.5	62.9	31.4	Molecular beacons: probes that fluoresce upon hybridization.	S Tyagi, F R Kramer	Nat Biotechnol	1996	9630890	Yes
1963	2297	1148.5	78.97	39.5	What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes.	J Zhang, K F Yu	JAMA	1998	9832001	Yes
1964	2295	1147.5	73.84	36.9	Epidemiology of invasive candidiasis: a persistent public health problem.	M A Pfaller, D J Diekema	Clin Microbiol Rev	2007	17223626	No
1965	3442	1147.3	87.93	29.3	Long non-coding RNAs: insights into functions.	Tim R Mercer, Marcel E Dinger, John S Mattick	Nat Rev Genet	2009	19188922	No
1966	2294	1147.0	0.0	0.0	Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.	A J Berk, P A Sharp	Cell	1977	922889	Yes
1967	2294	1147.0	71.42	35.7	The expanding universe of T-cell subsets: Th1, Th2 and more.	T R Mosmann, S Sad	Immunol Today	1996	8820272	No
1968	1147	1147.0	46.19	46.2	Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains.	K Anders Ericsson	Acad Med	2004	15383395	No
1969	1147	1147.0	31.41	31.4	Clinical features of metastatic bone disease and risk of skeletal morbidity.	Robert E Coleman	Clin Cancer Res	2006	17062708	No
1970	4583	1145.8	157.57	39.4	clusterProfiler: an R package for comparing biological themes among gene clusters.	Guangchuang Yu, Li-Gen Wang, Yanyan Han, Qing-Yu He	OMICS	2012	22455463	Yes
1971	2291	1145.5	65.18	32.6	The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity.	Clay B Holroyd, Michael G H Coles	Psychol Rev	2002	12374324	Yes
1972	2290	1145.0	62.07	31.0	Interneurons of the hippocampus.	T F Freund, G Buzsáki	Hippocampus	1996	8915675	No
1973	3435	1145.0	109.97	36.7	A rapid bootstrap algorithm for the RAxML Web servers.	Alexandros Stamatakis, Paul Hoover, Jacques Rougemont	Syst Biol	2008	18853362	Yes
1974	2289	1144.5	98.93	49.5	Universal chemical assay for the detection and determination of siderophores.	B Schwyn, J B Neilands	Anal Biochem	1987	2952030	Yes
1975	2288	1144.0	0.0	0.0	Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.	M Grunstein, D S Hogness	Proc Natl Acad Sci U S A	1975	1105573	Yes
1976	2288	1144.0	84.96	42.5	Polyamines.	C W Tabor, H Tabor	Annu Rev Biochem	1984	6206782	No
1977	2288	1144.0	45.75	22.9	Oncogenic kinase signalling.	P Blume-Jensen, T Hunter	Nature	2001	11357143	No
1978	1144	1144.0	33.04	33.0	The cancer stem cell: premises, promises and challenges.	Hans Clevers	Nat Med	2011	21386835	No
1979	1143	1143.0	46.37	46.4	Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology.	N Krieger	Am J Public Health	1992	1566949	Yes
1980	1143	1143.0	0.0	0.0	Electroimmuno assay.	C B Laurell	Scand J Clin Lab Invest Suppl	1972	4114358	Yes
1981	1143	1143.0	40.14	40.1	Signal transduction by reactive oxygen species.	Toren Finkel	J Cell Biol	2011	21746850	No
1982	4569	1142.2	159.68	39.9	Reversible middle cerebral artery occlusion without craniectomy in rats.	E Z Longa, P R Weinstein, S Carlson, R Cummins	Stroke	1989	2643202	Yes
1983	1142	1142.0	45.04	45.0	Metalloproteinases and their inhibitors in matrix remodeling.	L M Matrisian	Trends Genet	1990	2132731	No
1984	2284	1142.0	0.0	0.0	Junctional complexes in various epithelia.	M G FARQUHAR, G E PALADE	J Cell Biol	1963	13944428	Yes
1985	2283	1141.5	102.91	51.5	The integrative review: updated methodology.	Robin Whittemore, Kathleen Knafl	J Adv Nurs	2005	16268861	Yes
1986	3424	1141.3	0.0	0.0	Hydroperoxide metabolism in mammalian organs.	B Chance, H Sies, A Boveris	Physiol Rev	1979	37532	Yes
1987	2282	1141.0	0.0	0.0	Synchronization of Plasmodium falciparum erythrocytic stages in culture.	C Lambros, J P Vanderberg	J Parasitol	1979	383936	Yes
1988	1141	1141.0	37.48	37.5	Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation.	P Willner	Psychopharmacology (Berl)	1997	9452163	No
1989	1141	1141.0	23.3	23.3	NK cell receptors.	L L Lanier	Annu Rev Immunol	1998	9597134	No
1990	1141	1141.0	33.84	33.8	The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.	T Szkudelski	Physiol Res	2001	11829314	No
1991	1141	1141.0	32.82	32.8	The human orbitofrontal cortex: linking reward to hedonic experience.	Morten L Kringelbach	Nat Rev Neurosci	2005	16136173	No
1992	2281	1140.5	63.96	32.0	The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes.	Daniel J Drucker, Michael A Nauck	Lancet	2006	17098089	No
1993	1140	1140.0	38.19	38.2	Circuitry and functional aspects of the insular lobe in primates including humans.	J R Augustine	Brain Res Brain Res Rev	1996	8957561	No
1994	1140	1140.0	0.0	0.0	The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models.	R C Lewontin	Genetics	1964	17248194	Yes
1995	1139	1139.0	0.0	0.0	THE RELATION OF RECOMBINATION TO MUTATIONAL ADVANCE.	H J MULLER	Mutat Res	1964	14195748	Yes
1996	2277	1138.5	54.48	27.2	Escaping free-energy minima.	Alessandro Laio, Michele Parrinello	Proc Natl Acad Sci U S A	2002	12271136	Yes
1997	1138	1138.0	0.0	0.0	Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.	A Krishan	J Cell Biol	1975	49354	Yes
1998	1138	1138.0	0.0	0.0	The mechanism of muscular contraction.	H E Huxley	Science	1969	4181952	No
1999	1138	1138.0	50.55	50.5	Colorimetric determination of phospholipids with ammonium ferrothiocyanate.	J C Stewart	Anal Biochem	1980	6892980	Yes
2000	1138	1138.0	32.89	32.9	Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides.	Y Shai	Biochim Biophys Acta	1999	10590302	No
2001	2276	1138.0	0.0	0.0	A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.	J E TILL, E A McCULLOCH	Radiat Res	1961	13776896	Yes
2002	2276	1138.0	55.98	28.0	Cancer stem cells in solid tumours: accumulating evidence and unresolved questions.	Jane E Visvader, Geoffrey J Lindeman	Nat Rev Cancer	2008	18784658	No
2003	2275	1137.5	50.71	25.4	The molecular biology of axon guidance.	M Tessier-Lavigne, C S Goodman	Science	1996	8895455	No
2004	7962	1137.4	268.59	38.4	Cancer statistics, 2008.	Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J Thun	CA Cancer J Clin	2008	18287387	Yes
2005	3411	1137.0	84.2	28.1	Telomeres shorten during ageing of human fibroblasts.	C B Harley, A B Futcher, C W Greider	Nature	1990	2342578	Yes
2006	1137	1137.0	40.86	40.9	Osteoblast adhesion on biomaterials.	K Anselme	Biomaterials	2000	10711964	No
2007	1137	1137.0	0.0	0.0	PLASTIC EMBEDDING MIXTURES FOR USE IN ELECTRON MICROSCOPY.	H H MOLLENHAUER	Stain Technol	1964	14127791	Yes
2008	1136	1136.0	0.0	0.0	Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion.	S S Lehrer	Biochemistry	1971	5119250	Yes
2009	2271	1135.5	189.07	94.5	Natural Products as Sources of New Drugs from 1981 to 2014.	David J Newman, Gordon M Cragg	J Nat Prod	2016	26852623	No
2010	1135	1135.0	34.19	34.2	Rapid and sensitive sequence comparison with FASTP and FASTA.	W R Pearson	Methods Enzymol	1990	2156132	Yes
2011	1135	1135.0	35.42	35.4	The origins of the developmental origins theory.	D J P Barker	J Intern Med	2007	17444880	No
2012	2269	1134.5	0.0	0.0	Convergent and discriminant validation by the multitrait-multimethod matrix.	D T CAMPBELL, D W FISKE	Psychol Bull	1959	13634291	Yes
2013	1134	1134.0	0.0	0.0	Stimulated acoustic emissions from within the human auditory system.	D T Kemp	J Acoust Soc Am	1978	744838	Yes
2014	1134	1134.0	25.47	25.5	Endocytosis and molecular sorting.	I Mellman	Annu Rev Cell Dev Biol	1996	8970738	No
2015	1134	1134.0	27.68	27.7	Diarylethenes for Memories and Switches.	Masahiro Irie	Chem Rev	2000	11777416	Yes
2016	1134	1134.0	52.64	52.6	MorphoJ: an integrated software package for geometric morphometrics.	Christian Peter Klingenberg	Mol Ecol Resour	2011	21429143	Yes
2017	1133	1133.0	36.74	36.7	Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects.	E B Hunziker	Osteoarthritis Cartilage	2002	12056848	No
2018	2265	1132.5	65.4	32.7	Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.	E S Lander, D Botstein	Genetics	1989	2563713	Yes
2019	6795	1132.5	190.9	31.8	A default mode of brain function.	M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L Shulman	Proc Natl Acad Sci U S A	2001	11209064	Yes
2020	3394	1131.3	90.51	30.2	The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.	S K Hanks, A M Quinn, T Hunter	Science	1988	3291115	No
2021	1130	1130.0	0.0	0.0	Isolated removal of hypothalamic or other brain nuclei of the rat.	M Palkovits	Brain Res	1973	4747772	Yes
2022	3389	1129.7	104.19	34.7	Atomic force microscope.	Binnig, Quate, Gerber	Phys Rev Lett	1986	10033323	Yes
2023	1129	1129.0	30.27	30.3	Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?	Rui Wang	FASEB J	2002	12409322	Yes
2024	2256	1128.0	68.88	34.4	Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators.	I Issemann, S Green	Nature	1990	2129546	Yes
2025	1128	1128.0	56.3	56.3	Physiological aspects of primary hypertension.	B Folkow	Physiol Rev	1982	6461865	No
2026	2256	1128.0	89.57	44.8	Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art.	Johan W S Vlaeyen, Steven J Linton	Pain	2000	10781906	No
2027	2255	1127.5	115.69	57.8	A new initiative on precision medicine.	Francis S Collins, Harold Varmus	N Engl J Med	2015	25635347	Yes
2028	2254	1127.0	82.23	41.1	The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.	J D Hayes, D J Pulford	Crit Rev Biochem Mol Biol	1995	8770536	No
2029	3379	1126.3	85.91	28.6	Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides.	Christian W Tornøe, Caspar Christensen, Morten Meldal	J Org Chem	2002	11975567	Yes
2030	3378	1126.0	90.62	30.2	Thresholding of statistical maps in functional neuroimaging using the false discovery rate.	Christopher R Genovese, Nicole A Lazar, Thomas Nichols	Neuroimage	2002	11906227	Yes
2031	1126	1126.0	24.71	24.7	The significance of responses of the genome to challenge.	B McClintock	Science	1984	15739260	No
2032	2251	1125.5	49.72	24.9	Regulated portals of entry into the cell.	Sean D Conner, Sandra L Schmid	Nature	2003	12621426	No
2033	3376	1125.3	97.49	32.5	The metabolic syndrome.	Robert H Eckel, Scott M Grundy, Paul Z Zimmet	Lancet	2005	15836891	No
2034	2250	1125.0	100.76	50.4	The need to belong: desire for interpersonal attachments as a fundamental human motivation.	R F Baumeister, M R Leary	Psychol Bull	1995	7777651	No
2035	1125	1125.0	36.4	36.4	Multiple imputation of discrete and continuous data by fully conditional specification.	Stef van Buuren	Stat Methods Med Res	2007	17621469	Yes
2036	1124	1124.0	58.49	58.5	Negative symptoms in schizophrenia. Definition and reliability.	N C Andreasen	Arch Gen Psychiatry	1982	7165477	Yes
2037	1124	1124.0	27.0	27.0	HIF-1: mediator of physiological and pathophysiological responses to hypoxia.	G L Semenza	J Appl Physiol (1985)	2000	10749844	No
2038	1124	1124.0	20.93	20.9	The molecular motor toolbox for intracellular transport.	Ronald D Vale	Cell	2003	12600311	No
2039	1124	1124.0	0.0	0.0	DITHIOTHREITOL, A NEW PROTECTIVE REAGENT FOR SH GROUPS.	W W CLELAND	Biochemistry	1964	14192894	Yes
2040	8984	1123.0	251.61	31.5	Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain.	N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M Joliot	Neuroimage	2002	11771995	Yes
2041	3369	1123.0	83.86	28.0	Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?	Witold Filipowicz, Suvendra N Bhattacharyya, Nahum Sonenberg	Nat Rev Genet	2008	18197166	No
2042	1122	1122.0	33.94	33.9	Adult mesenchymal stem cells for tissue engineering versus regenerative medicine.	Arnold I Caplan	J Cell Physiol	2007	17620285	No
2043	1121	1121.0	41.36	41.4	Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications.	M D Maines	FASEB J	1988	3290025	No
2044	1121	1121.0	51.79	51.8	Presidential address, 1980. Surprise!...Surprise?	E Donchin	Psychophysiology	1981	7280146	Yes
2045	2241	1120.5	76.92	38.5	Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9164317	Yes
2046	1120	1120.0	42.66	42.7	Neurotransmitters and neuromodulators in the basal ganglia.	A M Graybiel	Trends Neurosci	1990	1695398	No
2047	1120	1120.0	40.97	41.0	Biological basis of the behavior of sick animals.	B L Hart	Neurosci Biobehav Rev	1988	3050629	No
2048	1120	1120.0	0.0	0.0	The oxidation of ribonuclease with performic acid.	C H HIRS	J Biol Chem	1956	13319283	Yes
2049	3360	1120.0	115.97	38.7	Simultaneous inference in general parametric models.	Torsten Hothorn, Frank Bretz, Peter Westfall	Biom J	2008	18481363	No
2050	6717	1119.5	210.2	35.0	Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.	Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur Wheeler	N Engl J Med	2000	10793162	Yes
2051	1118	1118.0	55.4	55.4	Reliability and factor analysis of the Epworth Sleepiness Scale.	M W Johns	Sleep	1992	1519015	Yes
2052	2236	1118.0	104.11	52.1	A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels.	C M Tsai, C E Frasch	Anal Biochem	1982	6176137	Yes
2053	1118	1118.0	22.03	22.0	microRNAs: tiny regulators with great potential.	V Ambros	Cell	2001	11779458	No
2054	2236	1118.0	81.17	40.6	Oxidative stress and diabetic complications.	Ferdinando Giacco, Michael Brownlee	Circ Res	2010	21030723	No
2055	5589	1117.8	188.47	37.7	Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication.	Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E Walters	Arch Gen Psychiatry	2005	15939839	Yes
2056	1117	1117.0	39.64	39.6	Chronic disease management: what will it take to improve care for chronic illness?	E H Wagner	Eff Clin Pract	1998	10345255	No
2057	3348	1116.0	76.25	25.4	A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.	R Medzhitov, P Preston-Hurlburt, C A Janeway	Nature	1997	9237759	Yes
2058	1116	1116.0	45.29	45.3	Plasma perspective on strong field multiphoton ionization.	Corkum	Phys Rev Lett	1993	10054556	Yes
2059	1116	1116.0	30.56	30.6	Proinflammatory cytokines.	C A Dinarello	Chest	2000	10936147	No
2060	1116	1116.0	34.48	34.5	Stress and depression.	Constance Hammen	Annu Rev Clin Psychol	2005	17716090	No
2061	1116	1116.0	26.94	26.9	DNA damage, aging, and cancer.	Jan H J Hoeijmakers	N Engl J Med	2009	19812404	No
2062	1116	1116.0	44.57	44.6	Inflammation in atherosclerosis.	Peter Libby	Arterioscler Thromb Vasc Biol	2012	22895665	No
2063	2231	1115.5	72.76	36.4	Transforming growth factor beta in tissue fibrosis.	W A Border, N A Noble	N Engl J Med	1994	7935686	No
2064	1115	1115.0	0.0	0.0	Estimability and estimation in case-referent studies.	O Miettinen	Am J Epidemiol	1976	1251836	Yes
2065	1115	1115.0	20.26	20.3	Clonal selection and learning in the antibody system.	K Rajewsky	Nature	1996	8657279	No
2066	2230	1115.0	90.46	45.2	How useful is SBF in predicting in vivo bone bioactivity?	Tadashi Kokubo, Hiroaki Takadama	Biomaterials	2006	16448693	No
2067	2227	1113.5	44.94	22.5	Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection.	C Li, W H Wong	Proc Natl Acad Sci U S A	2001	11134512	Yes
2068	1113	1113.0	33.25	33.2	Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders.	R M Sapolsky	Arch Gen Psychiatry	2000	11015810	No
2069	1113	1113.0	22.0	22.0	Mobile elements: drivers of genome evolution.	Haig H Kazazian	Science	2004	15016989	No
2070	2226	1113.0	46.07	23.0	A general framework for weighted gene co-expression network analysis.	Bin Zhang, Steve Horvath	Stat Appl Genet Mol Biol	2005	16646834	Yes
2071	1113	1113.0	34.55	34.5	The sympathetic control of blood pressure.	Patrice G Guyenet	Nat Rev Neurosci	2006	16760914	No
2072	1113	1113.0	26.5	26.5	Topoisomerase I inhibitors: camptothecins and beyond.	Yves Pommier	Nat Rev Cancer	2006	16990856	No
2073	1112	1112.0	0.0	0.0	The biologic clock: the mitochondria?	D Harman	J Am Geriatr Soc	1972	5016631	Yes
2074	6668	1111.3	177.86	29.6	GROMACS: fast, flexible, and free.	David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C Berendsen	J Comput Chem	2005	16211538	Yes
2075	1111	1111.0	32.96	33.0	Short-term synaptic plasticity.	R S Zucker	Annu Rev Neurosci	1989	2648947	No
2076	1111	1111.0	30.82	30.8	The cadherins: cell-cell adhesion molecules controlling animal morphogenesis.	M Takeichi	Development	1988	3048970	No
2077	1111	1111.0	47.5	47.5	Metallothionein.	D H Hamer	Annu Rev Biochem	1986	3527054	No
2078	2222	1111.0	46.49	23.2	Prediction of complete gene structures in human genomic DNA.	C Burge, S Karlin	J Mol Biol	1997	9149143	Yes
2079	3333	1111.0	78.9	26.3	OrthoMCL: identification of ortholog groups for eukaryotic genomes.	Li Li, Christian J Stoeckert, David S Roos	Genome Res	2003	12952885	Yes
2080	1111	1111.0	46.87	46.9	Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models.	T Florian Jaeger	J Mem Lang	2008	19884961	Yes
2081	1110	1110.0	48.07	48.1	Functional organization of central pathways regulating the cardiovascular system.	R A Dampney	Physiol Rev	1994	8171117	No
2082	1110	1110.0	44.18	44.2	Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data.	Thomas Heberer	Toxicol Lett	2002	11988354	Yes
2083	4438	1109.5	113.93	28.5	Quantitative monitoring of gene expression patterns with a complementary DNA microarray.	M Schena, D Shalon, R W Davis, P O Brown	Science	1995	7569999	Yes
2084	2219	1109.5	80.25	40.1	Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India.	D Filmer, L H Pritchett	Demography	2001	11227840	Yes
2085	1109	1109.0	44.79	44.8	SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test.	B P O'Connor	Behav Res Methods Instrum Comput	2000	11029811	Yes
2086	1109	1109.0	41.52	41.5	Ordinary magic. Resilience processes in development.	A S Masten	Am Psychol	2001	11315249	Yes
2087	1108	1108.0	27.39	27.4	E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.	J R Nevins	Science	1992	1411535	Yes
2088	2216	1108.0	45.74	22.9	Genetic transformation of Drosophila with transposable element vectors.	G M Rubin, A C Spradling	Science	1982	6289436	Yes
2089	1108	1108.0	30.9	30.9	Tobacco smoke carcinogens and lung cancer.	S S Hecht	J Natl Cancer Inst	1999	10413421	No
2090	1108	1108.0	25.56	25.6	The stem-cell niche as an entity of action.	David T Scadden	Nature	2006	16810242	No
2091	1108	1108.0	26.36	26.4	Transcriptional control of adipocyte formation.	Stephen R Farmer	Cell Metab	2006	17011499	No
2092	1107	1107.0	59.71	59.7	Optical properties of biological tissues: a review.	Steven L Jacques	Phys Med Biol	2013	23666068	No
2093	3320	1106.7	77.57	25.9	Multidrug resistance in cancer: role of ATP-dependent transporters.	Michael M Gottesman, Tito Fojo, Susan E Bates	Nat Rev Cancer	2002	11902585	No
2094	1106	1106.0	29.66	29.7	Developmental cell death: morphological diversity and multiple mechanisms.	P G Clarke	Anat Embryol (Berl)	1990	2186664	No
2095	1106	1106.0	35.14	35.1	Diagnosis of osteoporosis and assessment of fracture risk.	John A Kanis	Lancet	2002	12057569	No
2096	1106	1106.0	44.81	44.8	The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme.	Poul Erik Petersen	Community Dent Oral Epidemiol	2003	15015736	Yes
2097	2212	1106.0	63.54	31.8	ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins.	Markus Wiederstein, Manfred J Sippl	Nucleic Acids Res	2007	17517781	Yes
2098	1106	1106.0	29.1	29.1	Fast and robust fixed-point algorithms for independent component analysis.	A Hyvärinen	IEEE Trans Neural Netw	1999	18252563	Yes
2099	3317	1105.7	71.71	23.9	Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM).	Michael J Rust, Mark Bates, Xiaowei Zhuang	Nat Methods	2006	16896339	Yes
2100	2211	1105.5	0.0	0.0	THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.	T OMURA, R SATO	J Biol Chem	1964	14209972	Yes
2101	2211	1105.5	59.51	29.8	Regulation mechanisms and signaling pathways of autophagy.	Congcong He, Daniel J Klionsky	Annu Rev Genet	2009	19653858	No
2102	2211	1105.5	93.55	46.8	Van der Waals heterostructures.	A K Geim, I V Grigorieva	Nature	2013	23887427	Yes
2103	1105	1105.0	46.28	46.3	The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria.	A Raine	Schizophr Bull	1991	1805349	Yes
2104	1105	1105.0	55.86	55.9	The validity and practicality of sun-reactive skin types I through VI.	T B Fitzpatrick	Arch Dermatol	1988	3377516	Yes
2105	1105	1105.0	54.13	54.1	The role of hormone receptors and GTP-regulatory proteins in membrane transduction.	M Rodbell	Nature	1980	6101906	Yes
2106	2210	1105.0	71.17	35.6	Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis.	F D Lublin, S C Reingold	Neurology	1996	8780061	Yes
2107	2210	1105.0	50.78	25.4	Liver regeneration.	G K Michalopoulos, M C DeFrances	Science	1997	9082986	No
2108	2210	1105.0	67.74	33.9	Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies.	Robert E W Hancock, Hans-Georg Sahl	Nat Biotechnol	2006	17160061	No
2109	3314	1104.7	95.13	31.7	Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.	M A Frohman, M K Dush, G R Martin	Proc Natl Acad Sci U S A	1988	2461560	Yes
2110	3314	1104.7	91.94	30.6	Membrane lipids: where they are and how they behave.	Gerrit van Meer, Dennis R Voelker, Gerald W Feigenson	Nat Rev Mol Cell Biol	2008	18216768	No
2111	3311	1103.7	60.56	20.2	A system for stable expression of short interfering RNAs in mammalian cells.	Thijn R Brummelkamp, René Bernards, Reuven Agami	Science	2002	11910072	Yes
2112	2207	1103.5	74.71	37.4	Mortality by cause for eight regions of the world: Global Burden of Disease Study.	C J Murray, A D Lopez	Lancet	1997	9142060	Yes
2113	3309	1103.0	140.04	46.7	A new method for off-line removal of ocular artifact.	G Gratton, M G Coles, E Donchin	Electroencephalogr Clin Neurophysiol	1983	6187540	Yes
2114	1103	1103.0	49.54	49.5	UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure.	D W Russell	J Pers Assess	1996	8576833	Yes
2115	2206	1103.0	56.96	28.5	Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits.	Kornelia Polyak, Robert A Weinberg	Nat Rev Cancer	2009	19262571	No
2116	12129	1102.6	333.58	30.3	New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada.	P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G Gwyther	J Natl Cancer Inst	2000	10655437	No
2117	2205	1102.5	0.0	0.0	The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.	E G GRAY, V P WHITTAKER	J Anat	1962	13901297	Yes
2118	2205	1102.5	52.23	26.1	The pathophysiology of mitochondrial cell death.	Douglas R Green, Guido Kroemer	Science	2004	15286356	No
2119	1102	1102.0	39.82	39.8	A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation.	Ozcan Erel	Clin Biochem	2004	15003729	Yes
2120	1101	1101.0	21.08	21.1	c-Myc target genes involved in cell growth, apoptosis, and metabolism.	C V Dang	Mol Cell Biol	1999	9858526	No
2121	5501	1100.2	156.16	31.2	Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies.	Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory Collins	Lancet	2002	12493255	Yes
2122	1100	1100.0	0.0	0.0	Codon--anticodon pairing: the wobble hypothesis.	F H Crick	J Mol Biol	1966	5969078	Yes
2123	4400	1100.0	94.89	23.7	Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.	D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini	Science	2005	15718470	Yes
2124	2200	1100.0	0.0	0.0	Mutations of Bacteria from Virus Sensitivity to Virus Resistance.	S E Luria, M Delbrück	Genetics	1943	17247100	Yes
2125	1099	1099.0	34.36	34.4	Thioredoxin and glutaredoxin systems.	A Holmgren	J Biol Chem	1989	2668278	No
2126	2197	1098.5	78.63	39.3	An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat.	Sun Ho Kim, Jin Mo Chung	Pain	1992	1333581	Yes
2127	1098	1098.0	0.0	0.0	Hippocampal electrical activity and voluntary movement in the rat.	C H Vanderwolf	Electroencephalogr Clin Neurophysiol	1969	4183562	Yes
2128	1098	1098.0	28.78	28.8	Functions of the neurotrophins during nervous system development: what the knockouts are teaching us.	W D Snider	Cell	1994	8205613	No
2129	2196	1098.0	61.23	30.6	Pharmacology and functions of metabotropic glutamate receptors.	P J Conn, J P Pin	Annu Rev Pharmacol Toxicol	1997	9131252	No
2130	1098	1098.0	29.5	29.5	Optimal experimental design for event-related fMRI.	A M Dale	Hum Brain Mapp	1999	10524601	Yes
2131	6588	1098.0	167.85	28.0	Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.	Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O Lötvall	Nat Cell Biol	2007	17486113	Yes
2132	1098	1098.0	0.0	0.0	Diversity in tropical rain forests and coral reefs.	J H Connell	Science	1978	17840770	Yes
2133	1098	1098.0	31.28	31.3	Microbial influences in inflammatory bowel diseases.	R Balfour Sartor	Gastroenterology	2008	18242222	No
2134	2195	1097.5	77.81	38.9	The benefits of being present: mindfulness and its role in psychological well-being.	Kirk Warren Brown, Richard M Ryan	J Pers Soc Psychol	2003	12703651	Yes
2135	1097	1097.0	29.94	29.9	The 'effective number of codons' used in a gene.	F Wright	Gene	1990	2110097	Yes
2136	1097	1097.0	28.76	28.8	Protein kinase C: structure, function, and regulation.	A C Newton	J Biol Chem	1995	7499357	No
2137	1097	1097.0	30.63	30.6	Plasmonics: merging photonics and electronics at nanoscale dimensions.	Ekmel Ozbay	Science	2006	16410515	Yes
2138	2193	1096.5	55.16	27.6	Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins.	P J Mitchell, R Tjian	Science	1989	2667136	No
2139	4382	1095.5	0.0	0.0	A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples.	M A Markwell, S M Haas, L L Bieber, N E Tolbert	Anal Biochem	1978	98070	Yes
2140	1095	1095.0	46.35	46.4	Recent advances in the biochemistry of polyamines in eukaryotes.	A E Pegg	Biochem J	1986	3087344	No
2141	1095	1095.0	0.0	0.0	A soluble protein characteristic of the nervous system.	B W Moore	Biochem Biophys Res Commun	1965	4953930	Yes
2142	2190	1095.0	68.49	34.2	What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?	K C Berridge, T E Robinson	Brain Res Brain Res Rev	1998	9858756	No
2143	2189	1094.5	74.76	37.4	Angiogenesis.	J Folkman, Y Shing	J Biol Chem	1992	1375931	No
2144	1094	1094.0	0.0	0.0	Biological applications of ionophores.	B C Pressman	Annu Rev Biochem	1976	786156	No
2145	1094	1094.0	43.9	43.9	Turnover of inositol phospholipids and signal transduction.	Y Nishizuka	Science	1984	6147898	No
2146	1094	1094.0	21.97	22.0	CD95's deadly mission in the immune system.	P H Krammer	Nature	2000	11048730	No
2147	2187	1093.5	75.36	37.7	Quality control and preprocessing of metagenomic datasets.	Robert Schmieder, Robert Edwards	Bioinformatics	2011	21278185	Yes
2148	2186	1093.0	42.17	21.1	DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.	Christopher J Bakkenist, Michael B Kastan	Nature	2003	12556884	Yes
2149	1093	1093.0	28.37	28.4	Pathways of oxidative damage.	James A Imlay	Annu Rev Microbiol	2003	14527285	No
2150	1092	1092.0	42.32	42.3	Equipoise and the ethics of clinical research.	B Freedman	N Engl J Med	1987	3600702	Yes
2151	2184	1092.0	57.7	28.9	The MAPK signaling cascade.	R Seger, E G Krebs	FASEB J	1995	7601337	No
2152	2184	1092.0	62.64	31.3	Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients.	S Schulman, C Kearon	J Thromb Haemost	2005	15842354	Yes
2153	1091	1091.0	43.82	43.8	Glutathione metabolism and its selective modification.	A Meister	J Biol Chem	1988	3053703	No
2154	1091	1091.0	28.66	28.7	Codon usage and tRNA content in unicellular and multicellular organisms.	T Ikemura	Mol Biol Evol	1985	3916708	No
2155	1091	1091.0	52.8	52.8	An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results.	J Kabat-Zinn	Gen Hosp Psychiatry	1982	7042457	Yes
2156	2182	1091.0	56.84	28.4	The RXR heterodimers and orphan receptors.	D J Mangelsdorf, R M Evans	Cell	1995	8521508	No
2157	1091	1091.0	0.0	0.0	CHEMOAFFINITY IN THE ORDERLY GROWTH OF NERVE FIBER PATTERNS AND CONNECTIONS.	R W SPERRY	Proc Natl Acad Sci U S A	1963	14077501	Yes
2158	1091	1091.0	26.26	26.3	The Unified Medical Language System (UMLS): integrating biomedical terminology.	Olivier Bodenreider	Nucleic Acids Res	2004	14681409	Yes
2159	3273	1091.0	84.33	28.1	Tissue cells feel and respond to the stiffness of their substrate.	Dennis E Discher, Paul Janmey, Yu-Li Wang	Science	2005	16293750	No
2160	1091	1091.0	55.47	55.5	Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement.	Virginia A Moyer	Ann Intern Med	2014	24378917	No
2161	1090	1090.0	0.0	0.0	Bias in analytic research.	D L Sackett	J Chronic Dis	1979	447779	Yes
2162	1090	1090.0	0.0	0.0	The statistical analysis of enzyme kinetic data.	W W Cleland	Adv Enzymol Relat Areas Mol Biol	1967	4881884	No
2163	1090	1090.0	29.36	29.4	Reactive oxygen radicals in signaling and damage in the ischemic brain.	P H Chan	J Cereb Blood Flow Metab	2001	11149664	No
2164	1089	1089.0	26.05	26.1	Long-term potentiation and memory.	M A Lynch	Physiol Rev	2004	14715912	No
2165	3265	1088.3	87.9	29.3	Wnt/beta-catenin signaling: components, mechanisms, and diseases.	Bryan T MacDonald, Keiko Tamai, Xi He	Dev Cell	2009	19619488	No
2166	1088	1088.0	59.27	59.3	Mood and memory.	G H Bower	Am Psychol	1981	7224324	Yes
2167	1088	1088.0	24.68	24.7	Gene finding in novel genomes.	Ian Korf	BMC Bioinformatics	2004	15144565	Yes
2168	1087	1087.0	38.56	38.6	Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?	Thomas Grobner	Nephrol Dial Transplant	2006	16431890	Yes
2169	1086	1086.0	52.4	52.4	Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.	A H Conney	Cancer Res	1982	6814745	No
2170	4344	1086.0	108.12	27.0	Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.	Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J Thun	N Engl J Med	2003	12711737	Yes
2171	1086	1086.0	53.64	53.6	Selenium and human health.	Margaret P Rayman	Lancet	2012	22381456	No
2172	17375	1085.9	670.95	41.9	Fiji: an open-source platform for biological-image analysis.	Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid, Jean-Yves Tinevez, Daniel James White, Volker Hartenstein, Kevin Eliceiri, Pavel Tomancak, Albert Cardona	Nat Methods	2012	22743772	Yes
2173	2170	1085.0	53.74	26.9	Mitochondrial control of cell death.	G Kroemer, J C Reed	Nat Med	2000	10802706	No
2174	2170	1085.0	62.61	31.3	Neuronal plasticity: increasing the gain in pain.	C J Woolf, M W Salter	Science	2000	10846153	No
2175	1085	1085.0	30.9	30.9	Pain and emotion interactions in subregions of the cingulate gyrus.	Brent A Vogt	Nat Rev Neurosci	2005	15995724	No
2176	1085	1085.0	24.74	24.7	Solving structures of protein complexes by molecular replacement with Phaser.	Airlie J McCoy	Acta Crystallogr D Biol Crystallogr	2007	17164524	Yes
2177	2170	1085.0	61.77	30.9	Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments.	Gerard Talavera, Jose Castresana	Syst Biol	2007	17654362	Yes
2178	5423	1084.6	763.61	152.7	MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms.	Sudhir Kumar, Glen Stecher, Michael Li, Christina Knyaz, Koichiro Tamura	Mol Biol Evol	2018	29722887	Yes
2179	2169	1084.5	46.37	23.2	Gene silencing in cancer in association with promoter hypermethylation.	James G Herman, Stephen B Baylin	N Engl J Med	2003	14627790	No
2180	1084	1084.0	0.0	0.0	A graphic method for the determination and presentation of binding parameters in a complex system.	H E Rosenthal	Anal Biochem	1967	6048188	Yes
2181	1084	1084.0	74.33	74.3	Presynaptic regulation of the release of catecholamines.	S Z Langer	Pharmacol Rev	1980	6267618	Yes
2182	2167	1083.5	42.48	21.2	Live or let die: the cell's response to p53.	Karen H Vousden, Xin Lu	Nat Rev Cancer	2002	12154352	No
2183	6499	1083.2	179.45	29.9	Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research.	Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat Robles	Bioinformatics	2005	16081474	Yes
2184	2166	1083.0	0.0	0.0	3' non-coding region sequences in eukaryotic messenger RNA.	N J Proudfoot, G G Brownlee	Nature	1976	822353	Yes
2185	1083	1083.0	0.0	0.0	Some observations upon a new inhibitor of monoamine oxidase in brain tissue.	J P Johnston	Biochem Pharmacol	1968	5659776	Yes
2186	1082	1082.0	66.21	66.2	Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters.	P de Leva	J Biomech	1996	8872282	Yes
2187	1082	1082.0	32.69	32.7	Atopic dermatitis.	Thomas Bieber	N Engl J Med	2008	18385500	Yes
2188	2163	1081.5	79.41	39.7	Glycine potentiates the NMDA response in cultured mouse brain neurons.	J W Johnson, P Ascher	Nature	1987	2433595	Yes
2189	2162	1081.0	58.36	29.2	Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface.	D A Brown, J K Rose	Cell	1992	1531449	Yes
2190	3242	1080.7	73.41	24.5	Calcium signalling: dynamics, homeostasis and remodelling.	Michael J Berridge, Martin D Bootman, H Llewelyn Roderick	Nat Rev Mol Cell Biol	2003	12838335	No
2191	2160	1080.0	58.73	29.4	Microglia: active sensor and versatile effector cells in the normal and pathologic brain.	Uwe-Karsten Hanisch, Helmut Kettenmann	Nat Neurosci	2007	17965659	No
2192	2159	1079.5	0.0	0.0	Empirical predictions of protein conformation.	P Y Chou, G D Fasman	Annu Rev Biochem	1978	354496	No
2193	2158	1079.0	83.62	41.8	Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.	D S Bredt, S H Snyder	Proc Natl Acad Sci U S A	1990	1689048	Yes
2194	1079	1079.0	50.88	50.9	Social phobia.	M R Liebowitz	Mod Probl Pharmacopsychiatry	1987	2885745	Yes
2195	1079	1079.0	70.35	70.3	Subjective well-being.	E Diener	Psychol Bull	1984	6399758	No
2196	1079	1079.0	0.0	0.0	Note on the sampling error of the difference between correlated proportions or percentages.	Q McNEMAR	Psychometrika	1947	20254758	Yes
2197	2157	1078.5	57.4	28.7	Microenvironmental regulation of metastasis.	Johanna A Joyce, Jeffrey W Pollard	Nat Rev Cancer	2009	19279573	No
2198	1078	1078.0	37.05	37.0	Interleukin-1 in the pathogenesis and treatment of inflammatory diseases.	Charles A Dinarello	Blood	2011	21304099	No
2199	1077	1077.0	40.21	40.2	Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia.	A A Grace	Neuroscience	1991	1676137	No
2200	2154	1077.0	42.62	21.3	A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback.	D Tautz, C Pfeifle	Chromosoma	1989	2476281	Yes
2201	1077	1077.0	0.0	0.0	Carbonic anhydrase: chemistry, physiology, and inhibition.	T H Maren	Physiol Rev	1967	4964060	No
2202	1077	1077.0	37.29	37.3	Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES).	Gunther Eysenbach	J Med Internet Res	2004	15471760	No
2203	1076	1076.0	61.05	61.0	A new international staging system for lung cancer.	C F Mountain	Chest	1986	3514171	No
2204	1076	1076.0	25.2	25.2	Dimerization of cell surface receptors in signal transduction.	C H Heldin	Cell	1995	7834741	No
2205	2151	1075.5	71.38	35.7	CLUSTAL: a package for performing multiple sequence alignment on a microcomputer.	D G Higgins, P M Sharp	Gene	1988	3243435	Yes
2206	1075	1075.0	38.23	38.2	Integrins.	E Ruoslahti	J Clin Invest	1991	1985087	No
2207	1075	1075.0	0.0	0.0	A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces.	M G BUONOCORE	J Dent Res	1955	13271655	Yes
2208	1075	1075.0	27.5	27.5	Oxidative stress in neurodegeneration: cause or consequence?	Julie K Andersen	Nat Med	2004	15298006	No
2209	2150	1075.0	47.59	23.8	ERBB receptors and cancer: the complexity of targeted inhibitors.	Nancy E Hynes, Heidi A Lane	Nat Rev Cancer	2005	15864276	No
2210	11819	1074.5	381.21	34.7	The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.	Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J Roccella	JAMA	2003	12748199	No
2211	2149	1074.5	60.8	30.4	Nanostructures in biodiagnostics.	Nathaniel L Rosi, Chad A Mirkin	Chem Rev	2005	15826019	No
2212	1074	1074.0	35.64	35.6	Varieties of impulsivity.	J L Evenden	Psychopharmacology (Berl)	1999	10550486	No
2213	2148	1074.0	60.96	30.5	Therapeutic potential of resveratrol: the in vivo evidence.	Joseph A Baur, David A Sinclair	Nat Rev Drug Discov	2006	16732220	No
2214	3221	1073.7	107.78	35.9	Dose translation from animal to human studies revisited.	Shannon Reagan-Shaw, Minakshi Nihal, Nihal Ahmad	FASEB J	2008	17942826	Yes
2215	1073	1073.0	0.0	0.0	Cerebral blood flow and oxygen consumption in man.	N A LASSEN	Physiol Rev	1959	13645234	Yes
2216	1073	1073.0	30.33	30.3	Overview of general physiologic features and functions of vitamin D.	Hector F DeLuca	Am J Clin Nutr	2004	15585789	No
2217	1072	1072.0	30.42	30.4	Aspergillus fumigatus and aspergillosis.	J P Latgé	Clin Microbiol Rev	1999	10194462	No
2218	2144	1072.0	67.06	33.5	Antibiotic resistance of bacteria in biofilms.	P S Stewart, J W Costerton	Lancet	2001	11463434	No
2219	1072	1072.0	22.72	22.7	Lipid rafts: elusive or illusive?	Sean Munro	Cell	2003	14622593	No
2220	1072	1072.0	0.0	0.0	Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid.	W C SCHNEIDER	J Biol Chem	1945	21005736	Yes
2221	2143	1071.5	90.59	45.3	The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today.	R Doll, R Peto	J Natl Cancer Inst	1981	7017215	No
2222	1071	1071.0	31.8	31.8	Psychological and neural mechanisms of the affective dimension of pain.	D D Price	Science	2000	10846154	No
2223	1071	1071.0	24.38	24.4	Searching for genetic determinants in the new millennium.	N J Risch	Nature	2000	10866211	No
2224	1071	1071.0	34.16	34.2	Polycystic ovary syndrome.	David A Ehrmann	N Engl J Med	2005	15788499	No
2225	1071	1071.0	24.96	25.0	Recognition and processing of ubiquitin-protein conjugates by the proteasome.	Daniel Finley	Annu Rev Biochem	2009	19489727	No
2226	2141	1070.5	59.78	29.9	Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information.	M Zuker, P Stiegler	Nucleic Acids Res	1981	6163133	Yes
2227	1070	1070.0	33.05	33.0	Speculations on the functions of the major heat shock and glucose-regulated proteins.	H R Pelham	Cell	1986	2944601	Yes
2228	1070	1070.0	0.0	0.0	Computerized transverse axial scanning (tomography). 1. Description of system.	G N Hounsfield	Br J Radiol	1973	4757352	Yes
2229	1069	1069.0	37.94	37.9	Isolation and cultivation of Lyme disease spirochetes.	A G Barbour	Yale J Biol Med	1984	6393604	Yes
2230	1069	1069.0	26.57	26.6	The path to ubiquitous and low-cost organic electronic appliances on plastic.	Stephen R Forrest	Nature	2004	15118718	Yes
2231	1069	1069.0	24.51	24.5	Neuroligins and neurexins link synaptic function to cognitive disease.	Thomas C Südhof	Nature	2008	18923512	No
2232	2137	1068.5	0.0	0.0	Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats.	J Altman, G D Das	J Comp Neurol	1965	5861717	Yes
2233	2137	1068.5	64.2	32.1	Alternative activation of macrophages: mechanism and functions.	Siamon Gordon, Fernando O Martinez	Immunity	2010	20510870	No
2234	1068	1068.0	88.46	88.5	The three column spine and its significance in the classification of acute thoracolumbar spinal injuries.	F Denis	Spine (Phila Pa 1976)	1983	6670016	Yes
2235	1068	1068.0	31.1	31.1	Rapid evolution of a protein in vitro by DNA shuffling.	W P Stemmer	Nature	1994	8047147	Yes
2236	4271	1067.8	120.86	30.2	Microbial ecology: human gut microbes associated with obesity.	Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I Gordon	Nature	2006	17183309	Yes
2237	1067	1067.0	26.11	26.1	The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes.	S E Kahn	Diabetologia	2003	12637977	No
2238	7468	1066.9	157.56	22.5	Exploration, normalization, and summaries of high density oligonucleotide array probe level data.	Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P Speed	Biostatistics	2003	12925520	Yes
2239	3198	1066.0	185.15	61.7	Risk factors for falls among elderly persons living in the community.	M E Tinetti, M Speechley, S F Ginter	N Engl J Med	1988	3205267	Yes
2240	1066	1066.0	49.78	49.8	Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts).	G G Glenner	N Engl J Med	1980	6154243	No
2241	1066	1066.0	29.51	29.5	Primate anterior cingulate cortex: where motor control, drive and cognition interface.	T Paus	Nat Rev Neurosci	2001	11389475	No
2242	1066	1066.0	0.0	0.0	The theory and applications of the exchange of inert gas at the lungs and tissues.	S S KETY	Pharmacol Rev	1951	14833874	Yes
2243	5329	1065.8	102.59	20.5	Crystal structure of the nucleosome core particle at 2.8 A resolution.	K Luger, A W Mäder, R K Richmond, D F Sargent, T J Richmond	Nature	1997	9305837	Yes
2244	2130	1065.0	0.0	0.0	Post-embryonic cell lineages of the nematode, Caenorhabditis elegans.	J E Sulston, H R Horvitz	Dev Biol	1977	838129	Yes
2245	1065	1065.0	55.86	55.9	Cyclosporine.	B D Kahan	N Engl J Med	1989	2687689	No
2246	2130	1065.0	54.58	27.3	Disruption of epithelial cell-matrix interactions induces apoptosis.	S M Frisch, H Francis	J Cell Biol	1994	8106557	Yes
2247	1065	1065.0	27.21	27.2	Liver fibrosis -- from bench to bedside.	Scott L Friedman	J Hepatol	2003	12591185	No
2248	2128	1064.0	0.0	0.0	Regulatory sequences involved in the promotion and termination of RNA transcription.	M Rosenberg, D Court	Annu Rev Genet	1979	94251	No
2249	1064	1064.0	34.27	34.3	Cell and environment interactions in tumor microregions: the multicell spheroid model.	R M Sutherland	Science	1988	2451290	Yes
2250	1064	1064.0	0.0	0.0	Modality and topographic properties of single neurons of cat's somatic sensory cortex.	V B MOUNTCASTLE	J Neurophysiol	1957	13439410	Yes
2251	3192	1064.0	100.24	33.4	Nitric oxide and peroxynitrite in health and disease.	Pál Pacher, Joseph S Beckman, Lucas Liaudet	Physiol Rev	2007	17237348	No
2252	2127	1063.5	62.35	31.2	Neural systems of reinforcement for drug addiction: from actions to habits to compulsion.	Barry J Everitt, Trevor W Robbins	Nat Neurosci	2005	16251991	No
2253	4252	1063.0	108.86	27.2	Base-calling of automated sequencer traces using phred. I. Accuracy assessment.	B Ewing, L Hillier, M C Wendl, P Green	Genome Res	1998	9521921	Yes
2254	3187	1062.3	124.42	41.5	Rehospitalizations among patients in the Medicare fee-for-service program.	Stephen F Jencks, Mark V Williams, Eric A Coleman	N Engl J Med	2009	19339721	Yes
2255	2124	1062.0	56.01	28.0	Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene.	M E Greenberg, E B Ziff	Nature	1984	6090941	Yes
2256	1062	1062.0	44.61	44.6	Multimodal approach to control postoperative pathophysiology and rehabilitation.	H Kehlet	Br J Anaesth	1997	9175983	No
2257	1062	1062.0	0.0	0.0	The measurement of volume changes in human limbs.	R J WHITNEY	J Physiol	1953	13085295	Yes
2258	1061	1061.0	0.0	0.0	Calcium release from the sarcoplasmic reticulum.	M Endo	Physiol Rev	1977	13441	Yes
2259	1061	1061.0	0.0	0.0	The origin of the genetic code.	F H Crick	J Mol Biol	1968	4887876	Yes
2260	3182	1060.7	126.95	42.3	Factor structure of the Barratt impulsiveness scale.	J H Patton, M S Stanford, E S Barratt	J Clin Psychol	1995	8778124	Yes
2261	3182	1060.7	66.09	22.0	The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.	Fabio Martinon, Kimberly Burns, Jürg Tschopp	Mol Cell	2002	12191486	Yes
2262	2121	1060.5	39.51	19.8	The DNA damage response: putting checkpoints in perspective.	B B Zhou, S J Elledge	Nature	2000	11100718	No
2263	1060	1060.0	38.6	38.6	The Neuropsychiatric Inventory: assessing psychopathology in dementia patients.	J L Cummings	Neurology	1997	9153155	No
2264	2120	1060.0	59.27	29.6	Myocardial reperfusion injury.	Derek M Yellon, Derek J Hausenloy	N Engl J Med	2007	17855673	No
2265	2118	1059.0	90.05	45.0	Neutrophil recruitment and function in health and inflammation.	Elzbieta Kolaczkowska, Paul Kubes	Nat Rev Immunol	2013	23435331	No
2266	1058	1058.0	26.82	26.8	Physiological and molecular basis of thyroid hormone action.	P M Yen	Physiol Rev	2001	11427693	No
2267	1058	1058.0	22.15	22.1	IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors.	Yong-Jun Liu	Annu Rev Immunol	2005	15771572	No
2268	1057	1057.0	0.0	0.0	Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology.	W D Hamilton	Science	1967	6021675	Yes
2269	1057	1057.0	18.02	18.0	Themes and variations on ubiquitylation.	A M Weissman	Nat Rev Mol Cell Biol	2001	11265246	No
2270	1057	1057.0	25.81	25.8	Molecular physiology of low-voltage-activated t-type calcium channels.	Edward Perez-Reyes	Physiol Rev	2003	12506128	No
2271	2113	1056.5	63.27	31.6	Meeting of minds: the medial frontal cortex and social cognition.	David M Amodio, Chris D Frith	Nat Rev Neurosci	2006	16552413	No
2272	1056	1056.0	22.64	22.6	Mechanisms of caspase activation and inhibition during apoptosis.	Yigong Shi	Mol Cell	2002	11931755	No
2273	1056	1056.0	29.25	29.2	The hydrogen bond in the solid state.	Thomas Steiner	Angew Chem Int Ed Engl	2002	12491444	Yes
2274	1056	1056.0	30.83	30.8	Q-ball imaging.	David S Tuch	Magn Reson Med	2004	15562495	Yes
2275	2112	1056.0	70.14	35.1	The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin.	W L Jorgensen, J Tirado-Rives	J Am Chem Soc	1988	27557051	Yes
2276	1055	1055.0	32.04	32.0	The aryl hydrocarbon receptor complex.	O Hankinson	Annu Rev Pharmacol Toxicol	1995	7598497	No
2277	2110	1055.0	81.02	40.5	Oxidative mechanisms in the toxicity of metal ions.	S J Stohs, D Bagchi	Free Radic Biol Med	1995	7744317	No
2278	1055	1055.0	28.91	28.9	Papillomavirus infections--a major cause of human cancers.	H zur Hausen	Biochim Biophys Acta	1996	8876633	No
2279	1055	1055.0	34.0	34.0	Plant productivity and environment.	J S Boyer	Science	1982	17808529	Yes
2280	1055	1055.0	36.26	36.3	Endometriosis.	Serdar E Bulun	N Engl J Med	2009	19144942	No
2281	1055	1055.0	0.0	0.0	CRYSTALLINE SOYBEAN TRYPSIN INHIBITOR : II. GENERAL PROPERTIES.	M Kunitz	J Gen Physiol	1947	19873496	Yes
2282	2110	1055.0	106.44	53.2	ROS function in redox signaling and oxidative stress.	Michael Schieber, Navdeep S Chandel	Curr Biol	2014	24845678	No
2283	4219	1054.8	98.33	24.6	Interleukin-10 and the interleukin-10 receptor.	K W Moore, R de Waal Malefyt, R L Coffman, A O'Garra	Annu Rev Immunol	2001	11244051	No
2284	2109	1054.5	86.05	43.0	The framing of decisions and the psychology of choice.	A Tversky, D Kahneman	Science	1981	7455683	Yes
2285	1054	1054.0	25.94	25.9	S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles.	R Donato	Int J Biochem Cell Biol	2001	11390274	No
2286	1054	1054.0	26.46	26.5	Production of recombinant protein therapeutics in cultivated mammalian cells.	Florian M Wurm	Nat Biotechnol	2004	15529164	No
2287	2107	1053.5	45.89	22.9	Molecular chaperones in the cytosol: from nascent chain to folded protein.	F Ulrich Hartl, Manajit Hayer-Hartl	Science	2002	11884745	No
2288	1053	1053.0	31.75	31.8	Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles.	M Kozak	Microbiol Rev	1983	6343825	No
2289	1053	1053.0	24.32	24.3	Caspase structure, proteolytic substrates, and function during apoptotic cell death.	D W Nicholson	Cell Death Differ	1999	10578171	No
2290	1052	1052.0	37.59	37.6	Depression in late life: review and commentary.	Dan G Blazer	J Gerontol A Biol Sci Med Sci	2003	12634292	No
2291	1052	1052.0	37.07	37.1	The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases.	Artemis P Simopoulos	Exp Biol Med (Maywood)	2008	18408140	No
2292	5259	1051.8	244.81	49.0	Evidence based medicine: what it is and what it isn't.	D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S Richardson	BMJ	1996	8555924	No
2293	3154	1051.3	0.0	0.0	The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes.	J T DODGE, C MITCHELL, D J HANAHAN	Arch Biochem Biophys	1963	14028302	Yes
2294	1051	1051.0	36.75	36.8	A Wilcoxon-type test for trend.	J Cuzick	Stat Med	1985	3992076	Yes
2295	2101	1050.5	75.0	37.5	Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins.	D Marion, K Wüthrich	Biochem Biophys Res Commun	1983	6307308	Yes
2296	1050	1050.0	33.45	33.5	Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena.	U Mitzdorf	Physiol Rev	1985	3880898	No
2297	1050	1050.0	0.0	0.0	The ultrastructural basis of capillary permeability studied with peroxidase as a tracer.	M J Karnovsky	J Cell Biol	1967	6061717	Yes
2298	1050	1050.0	43.36	43.4	Inhibition and facilitation of nucleic acid amplification.	I G Wilson	Appl Environ Microbiol	1997	9327537	No
2299	2100	1050.0	58.97	29.5	The free radical theory of aging matures.	K B Beckman, B N Ames	Physiol Rev	1998	9562038	No
2300	1050	1050.0	25.77	25.8	Nuclear factor-kappaB: the enemy within.	Bharat B Aggarwal	Cancer Cell	2004	15380510	No
2301	1050	1050.0	30.15	30.1	Hydrogen sulphide and its therapeutic potential.	Csaba Szabó	Nat Rev Drug Discov	2007	17948022	No
2302	2100	1050.0	97.12	48.6	The M1 and M2 paradigm of macrophage activation: time for reassessment.	Fernando O Martinez, Siamon Gordon	F1000Prime Rep	2014	24669294	No
2303	3149	1049.7	137.31	45.8	Structure-antioxidant activity relationships of flavonoids and phenolic acids.	C A Rice-Evans, N J Miller, G Paganga	Free Radic Biol Med	1996	8743980	Yes
2304	9443	1049.2	373.82	41.5	The 1982 revised criteria for the classification of systemic lupus erythematosus.	E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J Winchester	Arthritis Rheum	1982	7138600	Yes
2305	1049	1049.0	32.41	32.4	Internal models for motor control and trajectory planning.	M Kawato	Curr Opin Neurobiol	1999	10607637	No
2306	1049	1049.0	25.37	25.4	Target-oriented and diversity-oriented organic synthesis in drug discovery.	S L Schreiber	Science	2000	10720315	No
2307	1049	1049.0	23.62	23.6	The roles of intracellular protein-degradation pathways in neurodegeneration.	David C Rubinsztein	Nature	2006	17051204	No
2308	1048	1048.0	0.0	0.0	Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.	K S McCully	Am J Pathol	1969	5792556	Yes
2309	1048	1048.0	39.8	39.8	An application of prefrontal cortex function theory to cognitive aging.	R L West	Psychol Bull	1996	8831298	No
2310	1048	1048.0	21.0	21.0	A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development.	Xuemei Chen	Science	2004	12893888	Yes
2311	1048	1048.0	0.0	0.0	Fluorescent antibody methods.	A H COONS	Gen Cytochem Methods	1958	13574437	Yes
2312	2094	1047.0	0.0	0.0	A general method for isolation of high molecular weight DNA from eukaryotes.	N Blin, D W Stafford	Nucleic Acids Res	1976	987581	Yes
2313	1047	1047.0	33.15	33.1	Cellular oncogenes and retroviruses.	J M Bishop	Annu Rev Biochem	1983	6351725	No
2314	1047	1047.0	42.71	42.7	Glycosphingolipids in cellular interaction, differentiation, and oncogenesis.	S Hakomori	Annu Rev Biochem	1981	7023369	No
2315	1047	1047.0	26.33	26.3	Double identity for proteins of the Bcl-2 family.	J C Reed	Nature	1997	9194558	No
2316	1047	1047.0	20.43	20.4	Kinesin and dynein superfamily proteins and the mechanism of organelle transport.	N Hirokawa	Science	1998	9438838	No
2317	1047	1047.0	32.32	32.3	Neural simulation of action: a unifying mechanism for motor cognition.	M Jeannerod	Neuroimage	2001	11373140	No
2318	1047	1047.0	29.68	29.7	Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics.	G L Semenza	Oncogene	2010	19946328	No
2319	1046	1046.0	19.19	19.2	Cancer susceptibility and the functions of BRCA1 and BRCA2.	Ashok R Venkitaraman	Cell	2002	11832208	No
2320	1046	1046.0	31.03	31.0	Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS.	Paul Willner	Neuropsychobiology	2005	16037678	No
2321	1046	1046.0	0.0	0.0	On the law of effect.	R J Herrnstein	J Exp Anal Behav	1970	16811440	Yes
2322	1046	1046.0	0.0	0.0	A new specific color reaction of hexuronic acids.	Z DISCHE	J Biol Chem	1947	20281638	Yes
2323	6274	1045.7	126.8	21.1	Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.	S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T Tuschl	Nature	2001	11373684	Yes
2324	1045	1045.0	39.54	39.5	Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.	A E Pegg	Cancer Res	1988	3123052	No
2325	1045	1045.0	0.0	0.0	Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate.	J W Olney	Science	1969	5778021	Yes
2326	1045	1045.0	34.83	34.8	Cytokinesis-block micronucleus cytome assay.	Michael Fenech	Nat Protoc	2007	17546000	Yes
2327	4178	1044.5	259.93	65.0	IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies.	Lam-Tung Nguyen, Heiko A Schmidt, Arndt von Haeseler, Bui Quang Minh	Mol Biol Evol	2015	25371430	Yes
2328	11487	1044.3	433.68	39.4	A new equation to estimate glomerular filtration rate.	Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef Coresh	Ann Intern Med	2009	19414839	Yes
2329	1044	1044.0	38.28	38.3	Classification of chronic viral hepatitis: a need for reassessment.	P J Scheuer	J Hepatol	1991	1808228	No
2330	1044	1044.0	54.65	54.6	The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence.	E J Khantzian	Am J Psychiatry	1985	3904487	No
2331	2087	1043.5	41.07	20.5	The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.	T Maehama, J E Dixon	J Biol Chem	1998	9593664	Yes
2332	3128	1042.7	83.66	27.9	Global and societal implications of the diabetes epidemic.	P Zimmet, K G Alberti, J Shaw	Nature	2001	11742409	No
2333	1042	1042.0	35.4	35.4	Rheumatoid arthritis. Pathophysiology and implications for therapy.	E D Harris	N Engl J Med	1990	2271017	No
2334	1042	1042.0	26.76	26.8	Huntington's disease.	Francis O Walker	Lancet	2007	17240289	No
2335	2083	1041.5	66.57	33.3	A review of central 5-HT receptors and their function.	N M Barnes, T Sharp	Neuropharmacology	1999	10462127	No
2336	2083	1041.5	72.64	36.3	Plasmonics for improved photovoltaic devices.	Harry A Atwater, Albert Polman	Nat Mater	2010	20168344	Yes
2337	2082	1041.0	56.38	28.2	Integrins and signal transduction pathways: the road taken.	E A Clark, J S Brugge	Science	1995	7716514	No
2338	2082	1041.0	64.23	32.1	The cognitive control of emotion.	Kevin N Ochsner, James J Gross	Trends Cogn Sci	2005	15866151	No
2339	2081	1040.5	50.34	25.2	Can the pharmaceutical industry reduce attrition rates?	Ismail Kola, John Landis	Nat Rev Drug Discov	2004	15286737	No
2340	1040	1040.0	0.0	0.0	Optimal foraging, the marginal value theorem.	E L Charnov	Theor Popul Biol	1976	1273796	Yes
2341	1040	1040.0	21.47	21.5	Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast.	R Rothstein	Methods Enzymol	1991	2005793	Yes
2342	2080	1040.0	66.55	33.3	Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule.	M D Pierschbacher, E Ruoslahti	Nature	1984	6325925	Yes
2343	2080	1040.0	60.52	30.3	Rising incidence of hepatocellular carcinoma in the United States.	H B El-Serag, A C Mason	N Engl J Med	1999	10072408	Yes
2344	2080	1040.0	75.22	37.6	Oncology meets immunology: the cancer-immunity cycle.	Daniel S Chen, Ira Mellman	Immunity	2013	23890059	No
2345	3117	1039.0	0.0	0.0	A highly sensitive adenylate cyclase assay.	Y Salomon, C Londos, M Rodbell	Anal Biochem	1974	4827395	Yes
2346	1039	1039.0	29.66	29.7	Mitochondrial fusion and fission in cell life and death.	Benedikt Westermann	Nat Rev Mol Cell Biol	2010	21102612	No
2347	3116	1038.7	83.77	27.9	Functional porous coordination polymers.	Susumu Kitagawa, Ryo Kitaura, Shin-ichiro Noro	Angew Chem Int Ed Engl	2004	15114565	Yes
2348	2077	1038.5	48.63	24.3	Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms.	Eugenia E Calle, Rudolf Kaaks	Nat Rev Cancer	2004	15286738	No
2349	1038	1038.0	0.0	0.0	Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report.	C S Neer	J Bone Joint Surg Am	1972	5054450	Yes
2350	2076	1038.0	159.33	79.7	A joint coordinate system for the clinical description of three-dimensional motions: application to the knee.	E S Grood, W J Suntay	J Biomech Eng	1983	6865355	Yes
2351	1038	1038.0	33.05	33.0	Emotion regulation: affective, cognitive, and social consequences.	James J Gross	Psychophysiology	2002	12212647	No
2352	2076	1038.0	73.38	36.7	An estimate of the worldwide prevalence and disability associated with osteoporotic fractures.	O Johnell, J A Kanis	Osteoporos Int	2006	16983459	Yes
2353	1038	1038.0	33.78	33.8	Water as an active constituent in cell biology.	Philip Ball	Chem Rev	2008	18095715	No
2354	2076	1038.0	92.61	46.3	Neoantigens in cancer immunotherapy.	Ton N Schumacher, Robert D Schreiber	Science	2015	25838375	No
2355	2075	1037.5	80.73	40.4	The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.	W R Gibb, A J Lees	J Neurol Neurosurg Psychiatry	1988	2841426	No
2356	1037	1037.0	30.52	30.5	Surrogate endpoints in clinical trials: definition and operational criteria.	R L Prentice	Stat Med	1989	2727467	Yes
2357	1037	1037.0	39.26	39.3	Pathogenetic mechanisms of septic shock.	J E Parrillo	N Engl J Med	1993	8479467	No
2358	1037	1037.0	29.9	29.9	Supported membranes: scientific and practical applications.	E Sackmann	Science	1996	8539599	No
2359	1037	1037.0	27.93	27.9	Matrix proteoglycans: from molecular design to cellular function.	R V Iozzo	Annu Rev Biochem	1998	9759499	No
2360	1037	1037.0	34.69	34.7	Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.	Felix Kratz	J Control Release	2008	18582981	No
2361	1037	1037.0	24.7	24.7	Human natural killer cells.	Michael A Caligiuri	Blood	2008	18650461	No
2362	1036	1036.0	27.77	27.8	Non-Smad pathways in TGF-beta signaling.	Ying E Zhang	Cell Res	2009	19114990	No
2363	7249	1035.6	252.39	36.1	AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility.	Garrett M Morris, Ruth Huey, William Lindstrom, Michel F Sanner, Richard K Belew, David S Goodsell, Arthur J Olson	J Comput Chem	2009	19399780	Yes
2364	2071	1035.5	0.0	0.0	Mutants of Escherichia coli requiring methionine or vitamin B12.	B D DAVIS, E S MINGIOLI	J Bacteriol	1950	15436457	Yes
2365	1035	1035.0	43.07	43.1	Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds.	A J Alpert	J Chromatogr	1990	2324207	Yes
2366	1035	1035.0	33.91	33.9	Type I diabetes mellitus. A chronic autoimmune disease.	G S Eisenbarth	N Engl J Med	1986	3517648	No
2367	2070	1035.0	48.38	24.2	CpG islands in vertebrate genomes.	M Gardiner-Garden, M Frommer	J Mol Biol	1987	3656447	Yes
2368	2070	1035.0	48.92	24.5	Functions of lipid rafts in biological membranes.	D A Brown, E London	Annu Rev Cell Dev Biol	1998	9891780	No
2369	1035	1035.0	62.92	62.9	Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial.	Kevin A Hallgren	Tutor Quant Methods Psychol	2012	22833776	Yes
2370	1035	1035.0	37.23	37.2	Breakthrough of the year 2013. Cancer immunotherapy.	Jennifer Couzin-Frankel	Science	2013	24357284	No
2371	2069	1034.5	55.08	27.5	The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications.	P M Sharp, W H Li	Nucleic Acids Res	1987	3547335	Yes
2372	2069	1034.5	66.78	33.4	Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.	C Auffray, F Rougeon	Eur J Biochem	1980	6772444	Yes
2373	1034	1034.0	0.0	0.0	Atherogenesis: a postprandial phenomenon.	D B Zilversmit	Circulation	1979	222498	Yes
2374	2068	1034.0	53.68	26.8	Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis.	M Fried, D M Crothers	Nucleic Acids Res	1981	6275366	Yes
2375	1034	1034.0	49.13	49.1	Translating social ecological theory into guidelines for community health promotion.	D Stokols	Am J Health Promot	1996	10159709	No
2376	3100	1033.3	99.65	33.2	Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles.	Günter Oberdörster, Eva Oberdörster, Jan Oberdörster	Environ Health Perspect	2005	16002369	No
2377	2066	1033.0	133.42	66.7	Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique.	S F Dworkin, L LeResche	J Craniomandib Disord	1992	1298767	No
2378	3099	1033.0	87.29	29.1	LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions.	A C Wallace, R A Laskowski, J M Thornton	Protein Eng	1995	7630882	Yes
2379	1033	1033.0	27.63	27.6	Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase.	P Kuzmic	Anal Biochem	1996	8660575	Yes
2380	1033	1033.0	24.81	24.8	Microglia as a source and target of cytokines.	Uwe-Karsten Hanisch	Glia	2002	12379902	No
2381	1033	1033.0	35.41	35.4	Mitochondria and cancer.	Douglas C Wallace	Nat Rev Cancer	2012	23001348	No
2382	1032	1032.0	0.0	0.0	Superoxide dismutases.	I Fridovich	Annu Rev Biochem	1975	1094908	No
2383	2064	1032.0	0.0	0.0	Prediction of protein conformation.	P Y Chou, G D Fasman	Biochemistry	1974	4358940	Yes
2384	1032	1032.0	0.0	0.0	Metabolic stability and epigenesis in randomly constructed genetic nets.	S A Kauffman	J Theor Biol	1969	5803332	Yes
2385	1032	1032.0	26.45	26.4	Mitochondrial transport of cations: channels, exchangers, and permeability transition.	P Bernardi	Physiol Rev	1999	10508231	No
2386	2064	1032.0	56.26	28.1	Drug delivery systems: entering the mainstream.	Theresa M Allen, Pieter R Cullis	Science	2004	15031496	Yes
2387	2063	1031.5	70.93	35.5	Accessories to the crime: functions of cells recruited to the tumor microenvironment.	Douglas Hanahan, Lisa M Coussens	Cancer Cell	2012	22439926	No
2388	2063	1031.5	92.98	46.5	The future of immune checkpoint therapy.	Padmanee Sharma, James P Allison	Science	2015	25838373	No
2389	3094	1031.3	139.48	46.5	Multiple imputation using chained equations: Issues and guidance for practice.	Ian R White, Patrick Royston, Angela M Wood	Stat Med	2011	21225900	Yes
2390	1031	1031.0	25.14	25.1	Neurobiology of Pavlovian fear conditioning.	S Maren	Annu Rev Neurosci	2001	11520922	No
2391	2062	1031.0	61.97	31.0	Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.	Ajay Kumar Gupta, Mona Gupta	Biomaterials	2005	15626447	No
2392	1031	1031.0	31.31	31.3	How brains beware: neural mechanisms of emotional attention.	Patrik Vuilleumier	Trends Cogn Sci	2005	16289871	Yes
2393	3092	1030.7	0.0	0.0	Improved method for the determination of blood glutathione.	E BEUTLER, O DURON, B M KELLY	J Lab Clin Med	1963	13967893	Yes
2394	4122	1030.5	106.06	26.5	Autophagy fights disease through cellular self-digestion.	Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky	Nature	2008	18305538	No
2395	2060	1030.0	0.0	0.0	Assay of proteins in the presence of interfering materials.	A Bensadoun, D Weinstein	Anal Biochem	1976	1259145	Yes
2396	1030	1030.0	31.27	31.3	VLA proteins in the integrin family: structures, functions, and their role on leukocytes.	M E Hemler	Annu Rev Immunol	1990	2188667	No
2397	1030	1030.0	0.0	0.0	The organization of proteins in the human red blood cell membrane. A review.	T L Steck	J Cell Biol	1974	4600883	No
2398	2060	1030.0	64.39	32.2	Increasing incidence of thyroid cancer in the United States, 1973-2002.	Louise Davies, H Gilbert Welch	JAMA	2006	16684987	Yes
2399	2059	1029.5	97.46	48.7	Malondialdehyde determination as index of lipid peroxidation.	H H Draper, M Hadley	Methods Enzymol	1990	2233309	Yes
2400	2058	1029.0	0.0	0.0	Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration.	D B Dill, D L Costill	J Appl Physiol	1974	4850854	Yes
2401	2058	1029.0	131.22	65.6	A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain.	M Roland, R Morris	Spine (Phila Pa 1976)	1983	6222486	Yes
2402	1029	1029.0	64.49	64.5	The brain's default mode network.	Marcus E Raichle	Annu Rev Neurosci	2015	25938726	No
2403	1028	1028.0	0.0	0.0	Defective repair replication of DNA in xeroderma pigmentosum.	J E Cleaver	Nature	1968	5655953	Yes
2404	2056	1028.0	101.71	50.9	Reading senseless sentences: brain potentials reflect semantic incongruity.	M Kutas, S A Hillyard	Science	1980	7350657	Yes
2405	1028	1028.0	33.6	33.6	The induction of pain: an integrative review.	M J Millan	Prog Neurobiol	1999	9987804	No
2406	1028	1028.0	28.86	28.9	The neuropathology of schizophrenia. A critical review of the data and their interpretation.	P J Harrison	Brain	1999	10219775	No
2407	1028	1028.0	29.18	29.2	Wound healing and its impairment in the diabetic foot.	Vincent Falanga	Lancet	2005	16291068	No
2408	3083	1027.7	113.1	37.7	Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria.	S van der Linden, H A Valkenburg, A Cats	Arthritis Rheum	1984	6231933	Yes
2409	7193	1027.6	286.37	40.9	GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.	Gordon H Guyatt, Andrew D Oxman, Gunn E Vist, Regina Kunz, Yngve Falck-Ytter, Pablo Alonso-Coello, Holger J Schünemann	BMJ	2008	18436948	Yes
2410	2055	1027.5	62.81	31.4	Imaging cognition II: An empirical review of 275 PET and fMRI studies.	R Cabeza, L Nyberg	J Cogn Neurosci	2000	10769304	No
2411	1027	1027.0	23.23	23.2	Assortative mixing in networks.	M E J Newman	Phys Rev Lett	2002	12443515	Yes
2412	2054	1027.0	45.94	23.0	The mammalian unfolded protein response.	Martin Schröder, Randal J Kaufman	Annu Rev Biochem	2005	15952902	No
2413	9243	1027.0	674.06	74.9	Cancer statistics in China, 2015.	Wanqing Chen, Rongshou Zheng, Peter D Baade, Siwei Zhang, Hongmei Zeng, Freddie Bray, Ahmedin Jemal, Xue Qin Yu, Jie He	CA Cancer J Clin	2016	26808342	Yes
2414	1026	1026.0	0.0	0.0	The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept.	A G Pearse	J Histochem Cytochem	1969	4143745	No
2415	1026	1026.0	23.8	23.8	Version 1.2 of the Crystallography and NMR system.	Axel T Brunger	Nat Protoc	2007	18007608	Yes
2416	3077	1025.7	68.9	23.0	Adjusting batch effects in microarray expression data using empirical Bayes methods.	W Evan Johnson, Cheng Li, Ariel Rabinovic	Biostatistics	2007	16632515	Yes
2417	2051	1025.5	45.71	22.9	Tumorigenesis and the angiogenic switch.	Gabriele Bergers, Laura E Benjamin	Nat Rev Cancer	2003	12778130	No
2418	4102	1025.5	167.59	41.9	Prevalence and trends in obesity among US adults, 1999-2008.	Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R Curtin	JAMA	2010	20071471	Yes
2419	1025	1025.0	0.0	0.0	An enzymic method for the trace iodination of immunoglobulins and other proteins.	J J Marchalonis	Biochem J	1969	4185494	Yes
2420	1025	1025.0	26.01	26.0	The prefrontal cortex and cognitive control.	E K Miller	Nat Rev Neurosci	2000	11252769	No
2421	3074	1024.7	69.74	23.2	Toll-like receptors: critical proteins linking innate and acquired immunity.	S Akira, K Takeda, T Kaisho	Nat Immunol	2001	11477402	No
2422	1024	1024.0	47.79	47.8	Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living.	S Katz	J Am Geriatr Soc	1983	6418786	No
2423	1024	1024.0	22.91	22.9	Morphogenetic roles of classic cadherins.	M Takeichi	Curr Opin Cell Biol	1995	8573335	No
2424	2047	1023.5	50.21	25.1	Adaptive protein evolution at the Adh locus in Drosophila.	J H McDonald, M Kreitman	Nature	1991	1904993	Yes
2425	2047	1023.5	38.35	19.2	Stats: transcriptional control and biological impact.	David E Levy, J E Darnell	Nat Rev Mol Cell Biol	2002	12209125	No
2426	1023	1023.0	23.9	23.9	Physiological concentrations of purines and pyrimidines.	T W Traut	Mol Cell Biochem	1994	7877593	No
2427	1023	1023.0	40.92	40.9	Density matrix formulation for quantum renormalization groups.	White	Phys Rev Lett	1992	10046608	Yes
2428	1023	1023.0	26.38	26.4	Metastatic bone disease: clinical features, pathophysiology and treatment strategies.	R E Coleman	Cancer Treat Rev	2001	11417967	No
2429	1023	1023.0	29.32	29.3	Polymer conjugates as anticancer nanomedicines.	Ruth Duncan	Nat Rev Cancer	2006	16900224	No
2430	3066	1022.0	0.0	0.0	Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins.	J Garnier, D J Osguthorpe, B Robson	J Mol Biol	1978	642007	Yes
2431	1022	1022.0	39.6	39.6	The epidemiology of adult obstructive sleep apnea.	Naresh M Punjabi	Proc Am Thorac Soc	2008	18250205	No
2432	1022	1022.0	39.7	39.7	The amazing osteocyte.	Lynda F Bonewald	J Bone Miner Res	2011	21254230	No
2433	1022	1022.0	40.15	40.1	The role of autophagy in neurodegenerative disease.	Ralph A Nixon	Nat Med	2013	23921753	No
2434	2043	1021.5	80.44	40.2	How good are my data and what is the resolution?	Philip R Evans, Garib N Murshudov	Acta Crystallogr D Biol Crystallogr	2013	23793146	Yes
2435	1021	1021.0	53.64	53.6	Human agency in social cognitive theory.	A Bandura	Am Psychol	1989	2782727	Yes
2436	1021	1021.0	0.0	0.0	The intraclass correlation coefficient as a measure of reliability.	J J Bartko	Psychol Rep	1966	5942109	Yes
2437	1021	1021.0	35.41	35.4	Invasive aspergillosis.	D W Denning	Clin Infect Dis	1998	9564455	No
2438	1021	1021.0	30.58	30.6	Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence.	Earl S Ford	Diabetes Care	2005	15983333	No
2439	3061	1020.3	106.93	35.6	The functional anatomy of basal ganglia disorders.	R L Albin, A B Young, J B Penney	Trends Neurosci	1989	2479133	No
2440	1020	1020.0	30.38	30.4	The lipocalin protein family: structure and function.	D R Flower	Biochem J	1996	8761444	No
2441	1020	1020.0	29.49	29.5	Neural systems for recognizing emotion.	Ralph Adolphs	Curr Opin Neurobiol	2002	12015233	No
2442	1020	1020.0	30.39	30.4	Physiology and pathophysiology of purinergic neurotransmission.	Geoffrey Burnstock	Physiol Rev	2007	17429044	No
2443	2039	1019.5	64.3	32.1	Epidemiology and outcomes of osteoporotic fractures.	Steven R Cummings, L Joseph Melton	Lancet	2002	12049882	No
2444	2039	1019.5	49.56	24.8	Toll-like receptors in innate immunity.	Kiyoshi Takeda, Shizuo Akira	Int Immunol	2005	15585605	No
2445	2039	1019.5	47.83	23.9	The canonical Notch signaling pathway: unfolding the activation mechanism.	Raphael Kopan, Maria Xenia G Ilagan	Cell	2009	19379690	No
2446	3058	1019.3	68.23	22.7	Cellular survival: a play in three Akts.	S R Datta, A Brunet, M E Greenberg	Genes Dev	1999	10579998	No
2447	1019	1019.0	70.04	70.0	The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation.	G A Ilizarov	Clin Orthop Relat Res	1989	2910611	Yes
2448	1019	1019.0	23.31	23.3	STATs: signal transducers and activators of transcription.	J N Ihle	Cell	1996	8608586	No
2449	1019	1019.0	0.0	0.0	LINKED FUNCTIONS AND RECIPROCAL EFFECTS IN HEMOGLOBIN: A SECOND LOOK.	J WYMAN	Adv Protein Chem	1964	14268785	No
2450	2037	1018.5	0.0	0.0	Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents.	L F Berkman, S L Syme	Am J Epidemiol	1979	425958	Yes
2451	1018	1018.0	46.05	46.0	The life and times of the Enterococcus.	B E Murray	Clin Microbiol Rev	1990	2404568	No
2452	1018	1018.0	0.0	0.0	A comparison of canal preparations in straight and curved root canals.	S W Schneider	Oral Surg Oral Med Oral Pathol	1971	5284110	Yes
2453	1018	1018.0	60.79	60.8	Derivation and validation of a short-form oral health impact profile.	G D Slade	Community Dent Oral Epidemiol	1997	9332805	Yes
2454	1018	1018.0	26.34	26.3	Optical microcavities.	Kerry J Vahala	Nature	2003	12917698	Yes
2455	1018	1018.0	0.0	0.0	The estimation of phosphorus.	R J Allen	Biochem J	1940	16747230	Yes
2456	1018	1018.0	40.16	40.2	Synopsis of some recent tactical application of bioisosteres in drug design.	Nicholas A Meanwell	J Med Chem	2011	21413808	Yes
2457	1017	1017.0	25.34	25.3	The impact of next-generation sequencing technology on genetics.	Elaine R Mardis	Trends Genet	2008	18262675	No
2458	7118	1016.9	361.54	51.6	Development and validation of a geriatric depression screening scale: a preliminary report.	J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O Leirer	J Psychiatr Res	1982	7183759	Yes
2459	2033	1016.5	47.05	23.5	Toll-like receptors in the induction of the innate immune response.	A Aderem, R J Ulevitch	Nature	2000	10963608	No
2460	2033	1016.5	38.5	19.2	Hedgehog signaling in animal development: paradigms and principles.	P W Ingham, A P McMahon	Genes Dev	2001	11731473	No
2461	3049	1016.3	77.54	25.8	Evolution and functions of long noncoding RNAs.	Chris P Ponting, Peter L Oliver, Wolf Reik	Cell	2009	19239885	No
2462	2032	1016.0	53.44	26.7	Peroxisome proliferator-activated receptors: nuclear control of metabolism.	B Desvergne, W Wahli	Endocr Rev	1999	10529898	No
2463	1016	1016.0	26.32	26.3	Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.	Hiroshi Takayanagi	Nat Rev Immunol	2007	17380158	No
2464	1016	1016.0	58.18	58.2	Nonalcoholic fatty liver disease: a systematic review.	Mary E Rinella	JAMA	2015	26057287	No
2465	1015	1015.0	31.57	31.6	Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective.	Antoine Bechara	Nat Neurosci	2005	16251988	No
2466	2029	1014.5	70.89	35.4	A cognitive model of posttraumatic stress disorder.	A Ehlers, D M Clark	Behav Res Ther	2000	10761279	No
2467	2029	1014.5	61.01	30.5	A neurotrophic model for stress-related mood disorders.	Ronald S Duman, Lisa M Monteggia	Biol Psychiatry	2006	16631126	No
2468	2029	1014.5	45.38	22.7	Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy.	S W Hell, J Wichmann	Opt Lett	1994	19844443	Yes
2469	3043	1014.3	66.43	22.1	Large-scale analysis of the yeast proteome by multidimensional protein identification technology.	M P Washburn, D Wolters, J R Yates	Nat Biotechnol	2001	11231557	Yes
2470	2028	1014.0	48.03	24.0	T-cell antigen receptor genes and T-cell recognition.	M M Davis, P J Bjorkman	Nature	1988	3043226	No
2471	1014	1014.0	86.64	86.6	The problem of rigor in qualitative research.	M Sandelowski	ANS Adv Nurs Sci	1986	3083765	Yes
2472	3042	1014.0	110.29	36.8	MR diffusion tensor spectroscopy and imaging.	P J Basser, J Mattiello, D LeBihan	Biophys J	1994	8130344	Yes
2473	1014	1014.0	39.24	39.2	Risk and maintenance factors for eating pathology: a meta-analytic review.	Eric Stice	Psychol Bull	2002	12206196	No
2474	1014	1014.0	35.24	35.2	Persister cells.	Kim Lewis	Annu Rev Microbiol	2010	20528688	No
2475	1013	1013.0	44.94	44.9	Quantitative methods in the review of epidemiologic literature.	S Greenland	Epidemiol Rev	1987	3678409	Yes
2476	1013	1013.0	18.68	18.7	Stem cells: units of development, units of regeneration, and units in evolution.	I L Weissman	Cell	2000	10647940	No
2477	2026	1013.0	45.33	22.7	NF-kappaB: linking inflammation and immunity to cancer development and progression.	Michael Karin, Florian R Greten	Nat Rev Immunol	2005	16175180	No
2478	1013	1013.0	28.61	28.6	Functionalized acenes and heteroacenes for organic electronics.	John E Anthony	Chem Rev	2006	17165682	Yes
2479	2026	1013.0	62.76	31.4	Integrins in cancer: biological implications and therapeutic opportunities.	Jay S Desgrosellier, David A Cheresh	Nat Rev Cancer	2010	20029421	No
2480	1012	1012.0	31.52	31.5	Normalization of cell responses in cat striate cortex.	D J Heeger	Vis Neurosci	1992	1504027	Yes
2481	1012	1012.0	34.74	34.7	Analyzing the mosaic structure of genes.	J M Smith	J Mol Evol	1992	1556748	No
2482	1012	1012.0	82.59	82.6	Impingement lesions.	C S Neer	Clin Orthop Relat Res	1983	6825348	Yes
2483	1012	1012.0	44.71	44.7	Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes.	M A Lemp	CLAO J	1995	8565190	No
2484	2023	1011.5	51.83	25.9	Emerging roles of caspase-3 in apoptosis.	A G Porter, R U Jänicke	Cell Death Differ	1999	10200555	No
2485	2023	1011.5	53.42	26.7	Raster3D Version 2.0. A program for photorealistic molecular graphics.	E A Merritt, M E Murphy	Acta Crystallogr D Biol Crystallogr	1994	15299354	Yes
2486	6067	1011.2	205.15	34.2	A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.	Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier	Science	2012	22745249	Yes
2487	1011	1011.0	26.27	26.3	Plant salt tolerance.	J K Zhu	Trends Plant Sci	2001	11173290	Yes
2488	1011	1011.0	37.42	37.4	Socioeconomic status and obesity.	Lindsay McLaren	Epidemiol Rev	2007	17478442	No
2489	1011	1011.0	24.52	24.5	Next-generation DNA sequencing methods.	Elaine R Mardis	Annu Rev Genomics Hum Genet	2008	18576944	No
2490	4043	1010.8	122.8	30.7	Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond.	Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S Vasan	Stat Med	2008	17569110	Yes
2491	3031	1010.3	88.96	29.7	Bacterial biofilms: from the natural environment to infectious diseases.	Luanne Hall-Stoodley, J William Costerton, Paul Stoodley	Nat Rev Microbiol	2004	15040259	No
2492	3030	1010.0	131.86	44.0	Vascular endothelial cells synthesize nitric oxide from L-arginine.	R M Palmer, D S Ashton, S Moncada	Nature	1988	3131684	Yes
2493	1010	1010.0	33.28	33.3	The molecular genetics of cancer.	J M Bishop	Science	1987	3541204	No
2494	1010	1010.0	32.19	32.2	The biochemistry and medical significance of the flavonoids.	Bent H Havsteen	Pharmacol Ther	2002	12453566	No
2495	1009	1009.0	0.0	0.0	Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein.	T Spector	Anal Biochem	1978	655375	Yes
2496	2018	1009.0	42.22	21.1	NF-kappaB at the crossroads of life and death.	Michael Karin, Anning Lin	Nat Immunol	2002	11875461	No
2497	2018	1009.0	40.99	20.5	Rho GTPases: biochemistry and biology.	Aron B Jaffe, Alan Hall	Annu Rev Cell Dev Biol	2005	16212495	No
2498	1008	1008.0	24.65	24.6	Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis.	Tirion	Phys Rev Lett	1996	10063201	Yes
2499	1008	1008.0	28.65	28.6	Somatostatin and its receptor family.	Y C Patel	Front Neuroendocrinol	1999	10433861	No
2500	1008	1008.0	26.11	26.1	Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis.	R Balfour Sartor	Nat Clin Pract Gastroenterol Hepatol	2006	16819502	No
2501	3023	1007.7	116.96	39.0	Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS.	B K Matuszewski, M L Constanzer, C M Chavez-Eng	Anal Chem	2003	12964746	Yes
2502	1007	1007.0	50.83	50.8	A cochlear frequency-position function for several species--29 years later.	D D Greenwood	J Acoust Soc Am	1990	2373794	Yes
2503	1007	1007.0	26.72	26.7	Oxyradicals and DNA damage.	L J Marnett	Carcinogenesis	2000	10688856	No
2504	1007	1007.0	27.91	27.9	Metabolism and functions of glutathione in brain.	R Dringen	Prog Neurobiol	2000	10880854	No
2505	1007	1007.0	17.34	17.3	Mitotic kinases as regulators of cell division and its checkpoints.	E A Nigg	Nat Rev Mol Cell Biol	2001	11413462	No
2506	1007	1007.0	36.81	36.8	Delirium in older persons.	Sharon K Inouye	N Engl J Med	2006	16540616	No
2507	2012	1006.0	65.53	32.8	Production of single-stranded plasmid DNA.	J Vieira, J Messing	Methods Enzymol	1987	3323803	Yes
2508	2011	1005.5	49.26	24.6	Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis.	Jing Yang, Robert A Weinberg	Dev Cell	2008	18539112	No
2509	2010	1005.0	0.0	0.0	Glutathione peroxidase activity in selenium-deficient rat liver.	R A Lawrence, R F Burk	Biochem Biophys Res Commun	1976	971321	Yes
2510	1005	1005.0	25.89	25.9	The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats.	G B Morin	Cell	1989	2805070	Yes
2511	4020	1005.0	113.92	28.5	Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites.	H Nielsen, J Engelbrecht, S Brunak, G von Heijne	Protein Eng	1997	9051728	Yes
2512	1005	1005.0	32.12	32.1	Low density lipoprotein oxidation and its pathobiological significance.	D Steinberg	J Biol Chem	1997	9261091	No
2513	1005	1005.0	21.87	21.9	Cytokines induce the development of functionally heterogeneous T helper cell subsets.	A O'Garra	Immunity	1998	9529145	No
2514	2008	1004.0	46.78	23.4	Sequence logos: a new way to display consensus sequences.	T D Schneider, R M Stephens	Nucleic Acids Res	1990	2172928	Yes
2515	1004	1004.0	22.33	22.3	Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy.	Harold F Dvorak	J Clin Oncol	2002	12409337	No
2516	2008	1004.0	40.82	20.4	An automated method for finding molecular complexes in large protein interaction networks.	Gary D Bader, Christopher W V Hogue	BMC Bioinformatics	2003	12525261	Yes
2517	1004	1004.0	22.15	22.1	Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution.	Sean B Carroll	Cell	2008	18614008	Yes
2518	1004	1004.0	34.35	34.4	phangorn: phylogenetic analysis in R.	Klaus Peter Schliep	Bioinformatics	2011	21169378	Yes
2519	2007	1003.5	74.5	37.2	Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.	J I Morgan, T Curran	Annu Rev Neurosci	1991	1903243	No
2520	4013	1003.2	175.57	43.9	Guidelines for the process of cross-cultural adaptation of self-report measures.	D E Beaton, C Bombardier, F Guillemin, M B Ferraz	Spine (Phila Pa 1976)	2000	11124735	No
2521	1003	1003.0	33.96	34.0	High prevalence of vitamin D inadequacy and implications for health.	Michael F Holick	Mayo Clin Proc	2006	16529140	No
2522	1002	1002.0	54.51	54.5	Biomaterial-centered infection: microbial adhesion versus tissue integration.	A G Gristina	Science	1987	3629258	Yes
2523	1002	1002.0	24.86	24.9	Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach.	Michael J Sanderson	Mol Biol Evol	2002	11752195	Yes
2524	3005	1001.7	82.92	27.6	Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm.	Y Zhang, M Brady, S Smith	IEEE Trans Med Imaging	2001	11293691	Yes
2525	2003	1001.5	0.0	0.0	Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.	G Blobel, B Dobberstein	J Cell Biol	1975	811671	Yes
2526	1001	1001.0	0.0	0.0	A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon.	A M Olovnikov	J Theor Biol	1973	4754905	Yes
2527	1001	1001.0	0.0	0.0	The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C.	R G Khalifah	J Biol Chem	1971	4994926	Yes
2528	1001	1001.0	23.6	23.6	The enzymes, regulation, and genetics of bile acid synthesis.	David W Russell	Annu Rev Biochem	2003	12543708	No
2529	1000	1000.0	35.56	35.6	Early signals in the mitogenic response.	E Rozengurt	Science	1986	3018928	No
2530	2000	1000.0	45.88	22.9	Atherosclerosis. the road ahead.	C K Glass, J L Witztum	Cell	2001	11239408	No
2531	1999	999.5	0.0	0.0	A new scale of social desirability independent of psychopathology.	D P CROWNE, D MARLOWE	J Consult Psychol	1960	13813058	Yes
2532	999	999.0	25.69	25.7	Brain tumors.	L M DeAngelis	N Engl J Med	2001	11150363	No
2533	1998	999.0	43.51	21.8	Plant pathogens and integrated defence responses to infection.	J L Dangl, J D Jones	Nature	2001	11459065	No
2534	999	999.0	32.79	32.8	The pollution of the marine environment by plastic debris: a review.	José G B Derraik	Mar Pollut Bull	2002	12405208	No
2535	1998	999.0	0.0	0.0	The effect of sodium ions on the electrical activity of giant axon of the squid.	A L HODGKIN, B KATZ	J Physiol	1949	18128147	Yes
2536	999	999.0	40.38	40.4	Volumetric modulated arc therapy: IMRT in a single gantry arc.	Karl Otto	Med Phys	2008	18293586	Yes
2537	999	999.0	45.52	45.5	Cytokines in inflammatory bowel disease.	Markus F Neurath	Nat Rev Immunol	2014	24751956	No
2538	1997	998.5	77.27	38.6	Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.	J E Hixson, D T Vernier	J Lipid Res	1990	2341813	Yes
2539	1997	998.5	50.14	25.1	Quorum sensing in bacteria.	M B Miller, B L Bassler	Annu Rev Microbiol	2001	11544353	No
2540	2994	998.0	85.98	28.7	Dystrophin: the protein product of the Duchenne muscular dystrophy locus.	E P Hoffman, R H Brown, L M Kunkel	Cell	1987	3319190	Yes
2541	2994	998.0	95.37	31.8	Molecular characterization of a peripheral receptor for cannabinoids.	S Munro, K L Thomas, M Abu-Shaar	Nature	1993	7689702	Yes
2542	998	998.0	35.08	35.1	The structure of common mental disorders.	R F Krueger	Arch Gen Psychiatry	1999	10530634	Yes
2543	998	998.0	0.0	0.0	Intra-sexual selection in Drosophila.	A J BATEMAN	Heredity (Edinb)	1948	18103134	Yes
2544	1995	997.5	68.41	34.2	Natural products as sources of new drugs over the last 25 years.	David J Newman, Gordon M Cragg	J Nat Prod	2007	17309302	No
2545	2991	997.0	178.52	59.5	In search of how people change. Applications to addictive behaviors.	J O Prochaska, C C DiClemente, J C Norcross	Am Psychol	1992	1329589	Yes
2546	1994	997.0	68.74	34.4	Analysis of gene control signals by DNA fusion and cloning in Escherichia coli.	M J Casadaban, S N Cohen	J Mol Biol	1980	6997493	Yes
2547	997	997.0	25.15	25.1	Heterotrimeric G proteins: organizers of transmembrane signals.	E J Neer	Cell	1995	7834744	No
2548	997	997.0	29.84	29.8	The basic science of gene therapy.	R C Mulligan	Science	1993	8493530	No
2549	997	997.0	0.0	0.0	A new readability yardstick.	R FLESCH	J Appl Psychol	1948	18867058	Yes
2550	1993	996.5	101.27	50.6	Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity.	P R Hunter, M A Gaston	J Clin Microbiol	1988	3069867	Yes
2551	1993	996.5	49.84	24.9	Next-generation DNA sequencing.	Jay Shendure, Hanlee Ji	Nat Biotechnol	2008	18846087	Yes
2552	996	996.0	29.51	29.5	Persister cells, dormancy and infectious disease.	Kim Lewis	Nat Rev Microbiol	2007	17143318	No
2553	995	995.0	33.77	33.8	Tumor necrosis factor (TNF).	L J Old	Science	1985	2413547	Yes
2554	995	995.0	20.29	20.3	Microarray data normalization and transformation.	John Quackenbush	Nat Genet	2002	12454644	No
2555	995	995.0	0.0	0.0	ANTIGEN-ANTIBODY CROSSED ELECTROPHORESIS.	C B LAURELL	Anal Biochem	1965	14302464	Yes
2556	995	995.0	25.68	25.7	Evaluating medication effects outside of clinical trials: new-user designs.	Wayne A Ray	Am J Epidemiol	2003	14585769	Yes
2557	1989	994.5	0.0	0.0	Selective loss of central cholinergic neurons in Alzheimer's disease.	P Davies, A J Maloney	Lancet	1976	63862	Yes
2558	1989	994.5	63.68	31.8	Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications.	Xiaobo Chen, Samuel S Mao	Chem Rev	2007	17590053	Yes
2559	994	994.0	44.31	44.3	Lyme disease.	A C Steere	N Engl J Med	1989	2668764	No
2560	1987	993.5	58.38	29.2	Hydrogels for tissue engineering: scaffold design variables and applications.	Jeanie L Drury, David J Mooney	Biomaterials	2003	12922147	No
2561	3973	993.2	0.0	0.0	Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.	D W Cleveland, S G Fischer, M W Kirschner, U K Laemmli	J Biol Chem	1977	320200	Yes
2562	3973	993.2	126.21	31.6	Toxic potential of materials at the nanolevel.	Andre Nel, Tian Xia, Lutz Mädler, Ning Li	Science	2006	16456071	No
2563	993	993.0	0.0	0.0	The measurement of psychological androgyny.	S L Bem	J Consult Clin Psychol	1974	4823550	Yes
2564	993	993.0	34.05	34.0	Modeling tracer kinetics in dynamic Gd-DTPA MR imaging.	P S Tofts	J Magn Reson Imaging	1997	9039598	No
2565	993	993.0	20.24	20.2	Regulation of phosphoinositide-specific phospholipase C.	S G Rhee	Annu Rev Biochem	2001	11395409	No
2566	993	993.0	19.75	19.8	Histone-deacetylase inhibitors: novel drugs for the treatment of cancer.	Ricky W Johnstone	Nat Rev Drug Discov	2002	12120280	No
2567	1986	993.0	74.86	37.4	Modified RECIST (mRECIST) assessment for hepatocellular carcinoma.	Riccardo Lencioni, Josep M Llovet	Semin Liver Dis	2010	20175033	No
2568	993	993.0	49.7	49.7	Working memory: theories, models, and controversies.	Alan Baddeley	Annu Rev Psychol	2012	21961947	No
2569	1986	993.0	87.41	43.7	PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data.	Daniel R Roe, Thomas E Cheatham	J Chem Theory Comput	2013	26583988	Yes
2570	1985	992.5	68.74	34.4	Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio.	Aluísio J D Barros, Vânia N Hirakata	BMC Med Res Methodol	2003	14567763	Yes
2571	992	992.0	33.99	34.0	Energy contributions of volatile fatty acids from the gastrointestinal tract in various species.	E N Bergman	Physiol Rev	1990	2181501	No
2572	992	992.0	32.56	32.6	The fetal and infant origins of adult disease.	D J Barker	BMJ	1990	2252919	No
2573	992	992.0	0.0	0.0	Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb.	J Altman	J Comp Neurol	1969	5361244	Yes
2574	992	992.0	21.76	21.8	Basement membranes: structure, assembly and role in tumour angiogenesis.	Raghu Kalluri	Nat Rev Cancer	2003	12778132	No
2575	992	992.0	20.52	20.5	Regulation of cadherin-mediated adhesion in morphogenesis.	Barry M Gumbiner	Nat Rev Mol Cell Biol	2005	16025097	No
2576	2975	991.7	100.99	33.7	Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections.	H King, R E Aubert, W H Herman	Diabetes Care	1998	9727886	Yes
2577	1983	991.5	45.97	23.0	Defining the role of mTOR in cancer.	David A Guertin, David M Sabatini	Cancer Cell	2007	17613433	No
2578	991	991.0	0.0	0.0	Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase.	H S Penefsky	J Biol Chem	1977	16006	Yes
2579	991	991.0	36.38	36.4	The aging process.	D Harman	Proc Natl Acad Sci U S A	1981	6947277	Yes
2580	991	991.0	23.24	23.2	Stem cells in the central nervous system.	R McKay	Science	1997	9082987	No
2581	991	991.0	18.76	18.8	The development of neural stem cells.	S Temple	Nature	2001	11689956	No
2582	991	991.0	34.22	34.2	The Hospital Anxiety And Depression Scale.	R Philip Snaith	Health Qual Life Outcomes	2003	12914662	Yes
2583	2973	991.0	73.98	24.7	Hepatocellular carcinoma.	Josep M Llovet, Andrew Burroughs, Jordi Bruix	Lancet	2003	14667750	No
2584	1982	991.0	59.15	29.6	Biology of incretins: GLP-1 and GIP.	Laurie L Baggio, Daniel J Drucker	Gastroenterology	2007	17498508	No
2585	990	990.0	0.0	0.0	Bee and wasp venoms.	E Habermann	Science	1972	4113805	No
2586	1980	990.0	137.35	68.7	The amyloid hypothesis of Alzheimer's disease at 25 years.	Dennis J Selkoe, John Hardy	EMBO Mol Med	2016	27025652	No
2587	989	989.0	42.44	42.4	The LMS method for constructing normalized growth standards.	T J Cole	Eur J Clin Nutr	1990	2354692	Yes
2588	989	989.0	49.77	49.8	Cardiac valve surgery--the "French correction".	A Carpentier	J Thorac Cardiovasc Surg	1983	6887954	Yes
2589	989	989.0	26.12	26.1	Allelic discrimination using fluorogenic probes and the 5' nuclease assay.	K J Livak	Genet Anal	1999	10084106	Yes
2590	1978	989.0	0.0	0.0	Maximum utilization of the life table method in analyzing survival.	S J CUTLER, F EDERER	J Chronic Dis	1958	13598782	Yes
2591	1978	989.0	63.04	31.5	Toll-like receptors and their crosstalk with other innate receptors in infection and immunity.	Taro Kawai, Shizuo Akira	Immunity	2011	21616434	No
2592	988	988.0	32.72	32.7	Phylogenies from molecular sequences: inference and reliability.	J Felsenstein	Annu Rev Genet	1988	3071258	No
2593	1976	988.0	85.63	42.8	Total energy intake: implications for epidemiologic analyses.	W Willett, M J Stampfer	Am J Epidemiol	1986	3521261	No
2594	988	988.0	64.29	64.3	The determinants of parenting: a process model.	J Belsky	Child Dev	1984	6705636	Yes
2595	988	988.0	26.12	26.1	Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration.	T A Springer	Annu Rev Physiol	1995	7778885	No
2596	988	988.0	0.0	0.0	The critical incident technique.	J C FLANAGAN	Psychol Bull	1954	13177800	Yes
2597	1976	988.0	49.49	24.7	Cellular processing of platinum anticancer drugs.	Dong Wang, Stephen J Lippard	Nat Rev Drug Discov	2005	15789122	No
2598	2964	988.0	71.38	23.8	Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo.	Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen	Science	2005	15831717	Yes
2599	2964	988.0	121.72	40.6	Hepatocellular carcinoma.	Alejandro Forner, Josep M Llovet, Jordi Bruix	Lancet	2012	22353262	No
2600	3951	987.8	141.1	35.3	Place navigation impaired in rats with hippocampal lesions.	R G Morris, P Garrud, J N Rawlins, J O'Keefe	Nature	1982	7088155	Yes
2601	4938	987.6	0.0	0.0	Transection of the oesophagus for bleeding oesophageal varices.	R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R Williams	Br J Surg	1973	4541913	Yes
2602	987	987.0	34.46	34.5	Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes.	W Sieghart	Pharmacol Rev	1995	7568326	No
2603	987	987.0	21.07	21.1	Inferences, questions and possibilities in Toll-like receptor signalling.	Bruce Beutler	Nature	2004	15241424	No
2604	3946	986.5	83.09	20.8	Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.	L Alexopoulou, A C Holt, R Medzhitov, R A Flavell	Nature	2001	11607032	Yes
2605	1972	986.0	0.0	0.0	Radiological demarcation of cemented sockets in total hip replacement.	J G DeLee, J Charnley	Clin Orthop Relat Res	1976	991504	Yes
2606	986	986.0	28.03	28.0	Molecular themes in oncogenesis.	J M Bishop	Cell	1991	1988146	No
2607	986	986.0	44.74	44.7	The structure of beta-lactamases.	R P Ambler	Philos Trans R Soc Lond B Biol Sci	1980	6109327	Yes
2608	986	986.0	22.67	22.7	Chromosomal translocations in human cancer.	T H Rabbitts	Nature	1994	7969446	No
2609	986	986.0	31.1	31.1	Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications.	P Lips	Endocr Rev	2001	11493580	No
2610	986	986.0	23.09	23.1	Platelets in atherothrombosis.	Zaverio M Ruggeri	Nat Med	2002	12411949	No
2611	1972	986.0	0.0	0.0	Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines.	G J TODARO, H GREEN	J Cell Biol	1963	13985244	Yes
2612	986	986.0	30.97	31.0	Infection in solid-organ transplant recipients.	Jay A Fishman	N Engl J Med	2007	18094380	No
2613	1971	985.5	48.65	24.3	A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells.	N C Andrews, D V Faller	Nucleic Acids Res	1991	2041787	Yes
2614	1971	985.5	71.18	35.6	Mediation in experimental and nonexperimental studies: new procedures and recommendations.	Patrick E Shrout, Niall Bolger	Psychol Methods	2002	12530702	Yes
2615	1971	985.5	58.8	29.4	EasySpin, a comprehensive software package for spectral simulation and analysis in EPR.	Stefan Stoll, Arthur Schweiger	J Magn Reson	2006	16188474	Yes
2616	1970	985.0	63.36	31.7	Supercoil sequencing: a fast and simple method for sequencing plasmid DNA.	E Y Chen, P H Seeburg	DNA	1985	3996185	Yes
2617	985	985.0	22.07	22.1	Apoptosis in neurodegenerative disorders.	M P Mattson	Nat Rev Mol Cell Biol	2000	11253364	No
2618	985	985.0	23.8	23.8	The myofibroblast in wound healing and fibrocontractive diseases.	G Gabbiani	J Pathol	2003	12845617	No
2619	2954	984.7	67.84	22.6	Predicting coiled coils from protein sequences.	A Lupas, M Van Dyke, J Stock	Science	1991	2031185	Yes
2620	2954	984.7	86.51	28.8	Methods in mammalian autophagy research.	Noboru Mizushima, Tamotsu Yoshimori, Beth Levine	Cell	2010	20144757	Yes
2621	1969	984.5	45.22	22.6	Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.	C W Greider, E H Blackburn	Cell	1985	3907856	Yes
2622	984	984.0	0.0	0.0	Drugs which inhibit prostaglandin biosynthesis.	R J Flower	Pharmacol Rev	1974	4208101	Yes
2623	984	984.0	33.44	33.4	Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies.	S L Friedman	N Engl J Med	1993	8502273	No
2624	984	984.0	21.52	21.5	Protein tyrosine phosphatases: from genes, to function, to disease.	Nicholas K Tonks	Nat Rev Mol Cell Biol	2006	17057753	No
2625	1968	984.0	56.24	28.1	Morris water maze: procedures for assessing spatial and related forms of learning and memory.	Charles V Vorhees, Michael T Williams	Nat Protoc	2006	17406317	Yes
2626	1968	984.0	62.14	31.1	Tumor metastasis: molecular insights and evolving paradigms.	Scott Valastyan, Robert A Weinberg	Cell	2011	22000009	No
2627	1966	983.0	62.82	31.4	Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.	R G Phillips, J E LeDoux	Behav Neurosci	1992	1590953	Yes
2628	983	983.0	22.85	22.9	Prediction of protein cellular attributes using pseudo-amino acid composition.	K C Chou	Proteins	2001	11288174	Yes
2629	3931	982.8	99.49	24.9	SCOP: a structural classification of proteins database for the investigation of sequences and structures.	A G Murzin, S E Brenner, T Hubbard, C Chothia	J Mol Biol	1995	7723011	Yes
2630	1965	982.5	93.2	46.6	The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure.	R Näätänen, T Picton	Psychophysiology	1987	3615753	Yes
2631	1964	982.0	55.87	27.9	Statistical tests of neutrality of mutations.	Y X Fu, W H Li	Genetics	1993	8454210	Yes
2632	1963	981.5	69.88	34.9	A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data.	A Ennaceur, J Delacour	Behav Brain Res	1988	3228475	Yes
2633	1961	980.5	76.53	38.3	Modeling and comparison of dissolution profiles.	P Costa, J M Sousa Lobo	Eur J Pharm Sci	2001	11297896	No
2634	980	980.0	0.0	0.0	Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.	J C Unkeless	J Exp Med	1979	90108	Yes
2635	980	980.0	0.0	0.0	A NEW WEIGHTING SYSTEM FOR MEAN SURFACE TEMPERATURE OF THE HUMAN BODY.	N L RAMANATHAN	J Appl Physiol	1964	14173555	Yes
2636	980	980.0	18.67	18.7	Biological robustness.	Hiroaki Kitano	Nat Rev Genet	2004	15520792	No
2637	980	980.0	33.0	33.0	Deconvoluting the context-dependent role for autophagy in cancer.	Eileen White	Nat Rev Cancer	2012	22534666	No
2638	1959	979.5	68.25	34.1	Health effects of fine particulate air pollution: lines that connect.	C Arden Pope, Douglas W Dockery	J Air Waste Manag Assoc	2006	16805397	No
2639	1959	979.5	97.97	49.0	Alginate: properties and biomedical applications.	Kuen Yong Lee, David J Mooney	Prog Polym Sci	2012	22125349	Yes
2640	979	979.0	30.32	30.3	The neurobiology of stress: from serendipity to clinical relevance.	B S McEwen	Brain Res	2000	11119695	No
2641	979	979.0	17.52	17.5	Molecular mechanisms of axon guidance.	Barry J Dickson	Science	2002	12471249	No
2642	1957	978.5	80.8	40.4	Atomic structure and chemistry of human serum albumin.	X M He, D C Carter	Nature	1992	1630489	Yes
2643	10761	978.3	321.0	29.2	The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data.	Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristo	Genome Res	2010	20644199	Yes
2644	978	978.0	19.36	19.4	Antigen receptor tail clue.	M Reth	Nature	1989	2927501	Yes
2645	978	978.0	27.19	27.2	Recent advances in neuroblastoma.	John M Maris	N Engl J Med	2010	20558371	No
2646	4888	977.6	201.62	40.3	The hallmarks of aging.	Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer	Cell	2013	23746838	No
2647	3910	977.5	97.19	24.3	A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.	Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry Sharpless	Angew Chem Int Ed Engl	2002	12203546	Yes
2648	1955	977.5	0.0	0.0	Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.	H J BLOOM, W W RICHARDSON	Br J Cancer	1957	13499785	Yes
2649	1955	977.5	52.75	26.4	Principles of bioactive lipid signalling: lessons from sphingolipids.	Yusuf A Hannun, Lina M Obeid	Nat Rev Mol Cell Biol	2008	18216770	No
2650	1955	977.5	68.46	34.2	Chronic hepatitis B: update 2009.	Anna S F Lok, Brian J McMahon	Hepatology	2009	19714720	Yes
2651	977	977.0	33.45	33.5	The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure.	K Kuwajima	Proteins	1989	2695928	No
2652	977	977.0	19.83	19.8	The power and the promise of DNA methylation markers.	Peter W Laird	Nat Rev Cancer	2003	12671664	No
2653	1954	977.0	53.92	27.0	C-reactive protein: a critical update.	Mark B Pepys, Gideon M Hirschfield	J Clin Invest	2003	12813013	No
2654	977	977.0	31.35	31.4	Stronger Brønsted acids.	Takahiko Akiyama	Chem Rev	2007	17983247	Yes
2655	977	977.0	47.57	47.6	α-band oscillations, attention, and controlled access to stored information.	Wolfgang Klimesch	Trends Cogn Sci	2012	23141428	No
2656	1953	976.5	47.01	23.5	Synaptic activity and the construction of cortical circuits.	L C Katz, C J Shatz	Science	1996	8895456	No
2657	976	976.0	46.31	46.3	Multiple calcium channels and neuronal function.	R J Miller	Science	1987	2432656	No
2658	976	976.0	40.52	40.5	Checklists for improving rigour in qualitative research: a case of the tail wagging the dog?	R S Barbour	BMJ	2001	11337448	No
2659	976	976.0	26.91	26.9	Comparative physiology of salt and water stress.	R. Munns	Plant Cell Environ	2002	11841667	Yes
2660	976	976.0	21.66	21.7	Microsatellites: simple sequences with complex evolution.	Hans Ellegren	Nat Rev Genet	2004	15153996	No
2661	976	976.0	51.15	51.1	Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'.	Konrad M Andrassy	Kidney Int	2013	23989362	Yes
2662	1951	975.5	76.18	38.1	Intracellular pH.	A Roos, W F Boron	Physiol Rev	1981	7012859	No
2663	975	975.0	0.0	0.0	Dopamine (3-hydroxytyramine) and brain function.	O Hornykiewicz	Pharmacol Rev	1966	5328389	No
2664	975	975.0	34.51	34.5	Diversity of group types, regulation, and function of phospholipase A2.	E A Dennis	J Biol Chem	1994	8175726	No
2665	975	975.0	0.0	0.0	A personality scale of manifest anxiety.	J A TAYLOR	J Abnorm Psychol	1953	13052352	Yes
2666	974	974.0	35.12	35.1	The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.	A S Fauci	Science	1988	3277274	No
2667	974	974.0	42.75	42.8	The theoretical bases of indirect calorimetry: a review.	E Ferrannini	Metabolism	1988	3278194	No
2668	974	974.0	0.0	0.0	Protein denaturation. C. Theoretical models for the mechanism of denaturation.	C Tanford	Adv Protein Chem	1970	4912353	No
2669	974	974.0	26.72	26.7	Neurons with graded response have collective computational properties like those of two-state neurons.	J J Hopfield	Proc Natl Acad Sci U S A	1984	6587342	Yes
2670	974	974.0	20.13	20.1	Focal adhesion kinase: the first ten years.	J Thomas Parsons	J Cell Sci	2003	12640026	No
2671	974	974.0	32.7	32.7	MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship.	Amy E Pasquinelli	Nat Rev Genet	2012	22411466	No
2672	973	973.0	32.92	32.9	Peptide antibiotics and their role in innate immunity.	H G Boman	Annu Rev Immunol	1995	7612236	No
2673	1946	973.0	58.68	29.3	Apoptosis, oncosis, and necrosis. An overview of cell death.	G Majno, I Joris	Am J Pathol	1995	7856735	No
2674	973	973.0	22.82	22.8	The finer things in X-ray diffraction data collection.	J W Pflugrath	Acta Crystallogr D Biol Crystallogr	1999	10531521	Yes
2675	973	973.0	38.75	38.8	AmpC beta-lactamases.	George A Jacoby	Clin Microbiol Rev	2009	19136439	No
2676	972	972.0	24.31	24.3	Pedigree disequilibrium tests for multilocus haplotypes.	Frank Dudbridge	Genet Epidemiol	2003	12916020	Yes
2677	972	972.0	32.55	32.5	Electrochemical glucose biosensors.	Joseph Wang	Chem Rev	2008	18154363	No
2678	2915	971.7	87.56	29.2	Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion.	Robert D Schreiber, Lloyd J Old, Mark J Smyth	Science	2011	21436444	No
2679	1942	971.0	0.0	0.0	Surgical risk as related to time of intervention in the repair of intracranial aneurysms.	W E Hunt, R M Hess	J Neurosurg	1968	5635959	Yes
2680	971	971.0	33.5	33.5	The somatic marker hypothesis and the possible functions of the prefrontal cortex.	A R Damasio	Philos Trans R Soc Lond B Biol Sci	1996	8941953	No
2681	971	971.0	21.13	21.1	Liver regeneration: from myth to mechanism.	Rebecca Taub	Nat Rev Mol Cell Biol	2004	15459664	No
2682	971	971.0	37.37	37.4	Tumor delivery of macromolecular drugs based on the EPR effect.	Vladimir Torchilin	Adv Drug Deliv Rev	2011	20304019	No
2683	3882	970.5	97.48	24.4	Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.	G L Wang, B H Jiang, E A Rue, G L Semenza	Proc Natl Acad Sci U S A	1995	7539918	Yes
2684	970	970.0	0.0	0.0	The interaction of a naphthalene dye with apomyoglobin and apohemoglobin. A fluorescent probe of non-polar binding sites.	L Stryer	J Mol Biol	1965	5867031	Yes
2685	970	970.0	33.88	33.9	Inferring microstructural features and the physiological state of tissues from diffusion-weighted images.	P J Basser	NMR Biomed	1995	8739270	No
2686	970	970.0	21.64	21.6	Regulation of transcription by MAP kinase cascades.	R Treisman	Curr Opin Cell Biol	1996	8791420	No
2687	2910	970.0	80.72	26.9	Functional diversity of helper T lymphocytes.	A K Abbas, K M Murphy, A Sher	Nature	1996	8893001	No
2688	970	970.0	23.42	23.4	How neutrophils kill microbes.	Anthony W Segal	Annu Rev Immunol	2005	15771570	No
2689	970	970.0	28.75	28.8	Thermo- and pH-responsive polymers in drug delivery.	Dirk Schmaljohann	Adv Drug Deliv Rev	2006	17125884	No
2690	970	970.0	25.61	25.6	Tumour necrosis factor and cancer.	Frances Balkwill	Nat Rev Cancer	2009	19343034	No
2691	970	970.0	35.3	35.3	Thermal properties of graphene and nanostructured carbon materials.	Alexander A Balandin	Nat Mater	2011	21778997	Yes
2692	969	969.0	23.04	23.0	Antigen-specific interaction between T and B cells.	A Lanzavecchia	Nature	1985	3157869	Yes
2693	969	969.0	61.16	61.2	Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale.	Anna Maria Carlsson	Pain	1983	6602967	Yes
2694	969	969.0	32.03	32.0	Papillary and follicular thyroid carcinoma.	M J Schlumberger	N Engl J Med	1998	9445411	No
2695	969	969.0	20.89	20.9	Mechanisms and consequences of activation of protein kinase B/Akt.	J Downward	Curr Opin Cell Biol	1998	9561851	No
2696	1937	968.5	68.87	34.4	Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC).	Kathryn M Connor, Jonathan R T Davidson	Depress Anxiety	2003	12964174	Yes
2697	1936	968.0	49.38	24.7	Cell cycle, CDKs and cancer: a changing paradigm.	Marcos Malumbres, Mariano Barbacid	Nat Rev Cancer	2009	19238148	No
2698	1936	968.0	46.98	23.5	Blinded by the Light: The Growing Complexity of p53.	Karen H Vousden, Carol Prives	Cell	2009	19410540	No
2699	1935	967.5	94.19	47.1	A simple method to assess exercise behavior in the community.	G Godin, R J Shephard	Can J Appl Sport Sci	1985	4053261	Yes
2700	5804	967.3	195.01	32.5	Free radicals and antioxidants in normal physiological functions and human disease.	Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua Telser	Int J Biochem Cell Biol	2007	16978905	No
2701	967	967.0	29.34	29.3	Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology.	E M Tan	Adv Immunol	1989	2646863	No
2702	967	967.0	27.9	27.9	Drug delivery and targeting.	R Langer	Nature	1998	9579855	No
2703	1934	967.0	47.84	23.9	Esophageal cancer.	Peter C Enzinger, Robert J Mayer	N Engl J Med	2003	14657432	No
2704	967	967.0	35.74	35.7	Platelet-rich plasma: evidence to support its use.	Robert E Marx	J Oral Maxillofac Surg	2004	15085519	No
2705	1933	966.5	0.0	0.0	Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G.	E Engvall, P Perlmann	Immunochemistry	1971	5135623	Yes
2706	966	966.0	22.38	22.4	Membrane recognition by phospholipid-binding domains.	Mark A Lemmon	Nat Rev Mol Cell Biol	2008	18216767	No
2707	1932	966.0	53.21	26.6	Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm.	Subhra K Biswas, Alberto Mantovani	Nat Immunol	2010	20856220	No
2708	965	965.0	0.0	0.0	Experience from a multicentre stroke register: a preliminary report.	S Hatano	Bull World Health Organ	1976	1088404	Yes
2709	965	965.0	43.32	43.3	Linkage map of Escherichia coli K-12, edition 7.	B J Bachmann	Microbiol Rev	1983	6348505	No
2710	1930	965.0	51.53	25.8	Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology.	M E Feder, G E Hofmann	Annu Rev Physiol	1999	10099689	No
2711	965	965.0	24.21	24.2	Translating cell biology into therapeutic advances in Alzheimer's disease.	D J Selkoe	Nature	1999	10392577	No
2712	965	965.0	0.0	0.0	On the Absorption of Fluids from the Connective Tissue Spaces.	E H Starling	J Physiol	1896	16992325	Yes
2713	964	964.0	0.0	0.0	A modified ninhydrin colorimetric analysis for amino acids.	H ROSEN	Arch Biochem Biophys	1957	13412116	Yes
2714	964	964.0	21.71	21.7	Phenotypic plasticity and the epigenetics of human disease.	Andrew P Feinberg	Nature	2007	17522677	No
2715	7711	963.9	229.19	28.6	A method and server for predicting damaging missense mutations.	Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R Sunyaev	Nat Methods	2010	20354512	Yes
2716	13489	963.5	319.3	22.8	Crystallography & NMR system: A new software suite for macromolecular structure determination.	A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L Warren	Acta Crystallogr D Biol Crystallogr	1998	9757107	Yes
2717	4816	963.2	102.16	20.4	Electrostatics of nanosystems: application to microtubules and the ribosome.	N A Baker, D Sept, S Joseph, M J Holst, J A McCammon	Proc Natl Acad Sci U S A	2001	11517324	Yes
2718	963	963.0	0.0	0.0	Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus.	P Rakic	J Comp Neurol	1971	4101340	Yes
2719	963	963.0	24.56	24.6	A tension-based theory of morphogenesis and compact wiring in the central nervous system.	D C Van Essen	Nature	1997	9002514	Yes
2720	2889	963.0	112.78	37.6	Qualitative research in health care. Analysing qualitative data.	C Pope, S Ziebland, N Mays	BMJ	2000	10625273	No
2721	963	963.0	19.77	19.8	The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities.	Y Yarden	Eur J Cancer	2001	11597398	No
2722	1926	963.0	51.41	25.7	Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival.	Josep M Llovet, Jordi Bruix	Hepatology	2003	12540794	No
2723	963	963.0	20.68	20.7	Automated NMR structure calculation with CYANA.	Peter Güntert	Methods Mol Biol	2004	15318003	Yes
2724	963	963.0	35.87	35.9	Electrocatalyst approaches and challenges for automotive fuel cells.	Mark K Debe	Nature	2012	22678278	Yes
2725	962	962.0	0.0	0.0	RNA metabolism in the HeLa cell nucleus.	S Penman	J Mol Biol	1966	5961144	Yes
2726	962	962.0	53.22	53.2	Free-radical mechanisms in tissue injury.	T F Slater	Biochem J	1984	6383353	No
2727	1924	962.0	56.9	28.4	Genetic dissection of complex traits.	E S Lander, N J Schork	Science	1994	8091226	No
2728	4809	961.8	289.17	57.8	Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee.	N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W Stitt	J Rheumatol	1988	3068365	Yes
2729	1923	961.5	78.42	39.2	Functional interactions between the gut microbiota and host metabolism.	Valentina Tremaroli, Fredrik Bäckhed	Nature	2012	22972297	No
2730	2883	961.0	55.67	18.6	Molecular genetic analysis of fission yeast Schizosaccharomyces pombe.	S Moreno, A Klar, P Nurse	Methods Enzymol	1991	2005825	Yes
2731	961	961.0	27.98	28.0	Disorders of iron metabolism.	N C Andrews	N Engl J Med	1999	10607817	No
2732	960	960.0	46.94	46.9	Bone "mass" and the "mechanostat": a proposal.	H M Frost	Anat Rec	1987	3688455	Yes
2733	960	960.0	0.0	0.0	Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol.	D B Clewell	J Bacteriol	1972	4336693	Yes
2734	1918	959.0	0.0	0.0	Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme.	A Warshel, M Levitt	J Mol Biol	1976	985660	Yes
2735	1918	959.0	0.0	0.0	Method for the isolation of intact islets of Langerhans from the rat pancreas.	P E Lacy, M Kostianovsky	Diabetes	1967	5333500	Yes
2736	959	959.0	30.44	30.4	Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.	C Taswell	J Immunol	1981	7009746	Yes
2737	959	959.0	17.13	17.1	Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism.	M S Wold	Annu Rev Biochem	1997	9242902	No
2738	1918	959.0	56.68	28.3	Chlorophyll fluorescence--a practical guide.	K Maxwell, G N Johnson	J Exp Bot	2000	10938857	No
2739	959	959.0	25.29	25.3	Anatomy and regulation of the central melanocortin system.	Roger D Cone	Nat Neurosci	2005	15856065	No
2740	959	959.0	19.61	19.6	ChIP-seq: advantages and challenges of a maturing technology.	Peter J Park	Nat Rev Genet	2009	19736561	No
2741	7670	958.8	256.47	32.1	The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment.	Ziad S Nasreddine, Natalie A Phillips, Valérie Bédirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L Cummings, Howard Chertkow	J Am Geriatr Soc	2005	15817019	Yes
2742	1917	958.5	66.2	33.1	Recent advances in the phencyclidine model of schizophrenia.	D C Javitt, S R Zukin	Am J Psychiatry	1991	1654746	No
2743	958	958.0	35.89	35.9	Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing.	M J Gasson	J Bacteriol	1983	6403500	Yes
2744	958	958.0	46.52	46.5	Neuropeptide Y: complete amino acid sequence of the brain peptide.	K Tatemoto	Proc Natl Acad Sci U S A	1982	6957876	Yes
2745	958	958.0	17.17	17.2	Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation.	Eric C Lai	Nat Genet	2002	11896390	Yes
2746	958	958.0	36.76	36.8	Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations.	Ronald A Hites	Environ Sci Technol	2004	14998004	Yes
2747	957	957.0	35.31	35.3	Relations between the statistics of natural images and the response properties of cortical cells.	D J Field	J Opt Soc Am A	1987	3430225	Yes
2748	957	957.0	21.22	21.2	Osmotic stress signaling and osmoadaptation in yeasts.	Stefan Hohmann	Microbiol Mol Biol Rev	2002	12040128	No
2749	957	957.0	52.21	52.2	Environmentally induced oxidative stress in aquatic animals.	Volodymyr I Lushchak	Aquat Toxicol	2011	21074869	No
2750	1913	956.5	67.27	33.6	Inflammatory mechanisms in obesity.	Margaret F Gregor, Gökhan S Hotamisligil	Annu Rev Immunol	2011	21219177	No
2751	5738	956.3	185.4	30.9	Cancer statistics, 2007.	Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Taylor Murray, Jiaquan Xu, Michael J Thun	CA Cancer J Clin	2007	17237035	Yes
2752	1912	956.0	45.89	22.9	Lymphocyte homing and homeostasis.	E C Butcher, L J Picker	Science	1996	8600538	No
2753	956	956.0	25.26	25.3	Context and behavioral processes in extinction.	Mark E Bouton	Learn Mem	2004	15466298	No
2754	956	956.0	23.26	23.3	Personal genomes: The case of the missing heritability.	Brendan Maher	Nature	2008	18987709	No
2755	956	956.0	45.5	45.5	What is self-rated health and why does it predict mortality? Towards a unified conceptual model.	Marja Jylhä	Soc Sci Med	2009	19520474	Yes
2756	1910	955.0	0.0	0.0	Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty.	J M Tanner, R H Whitehouse	Arch Dis Child	1976	952550	Yes
2757	1910	955.0	64.37	32.2	Nitric oxide synthases: roles, tolls, and controls.	C Nathan, Q W Xie	Cell	1994	7522969	No
2758	1910	955.0	39.81	19.9	Proliferation, cell cycle and apoptosis in cancer.	G I Evan, K H Vousden	Nature	2001	11357141	No
2759	1910	955.0	40.58	20.3	Community structure in social and biological networks.	M Girvan, M E J Newman	Proc Natl Acad Sci U S A	2002	12060727	No
2760	955	955.0	23.5	23.5	G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry.	Jeffery T Davis	Angew Chem Int Ed Engl	2004	14755695	No
2761	955	955.0	30.3	30.3	Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis.	P Vestergaard	Osteoporos Int	2007	17068657	No
2762	955	955.0	21.54	21.5	Up on the tightrope: natural killer cell activation and inhibition.	Lewis L Lanier	Nat Immunol	2008	18425106	No
2763	2864	954.7	99.53	33.2	SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building.	Manolo Gouy, Stéphane Guindon, Olivier Gascuel	Mol Biol Evol	2010	19854763	Yes
2764	1908	954.0	79.34	39.7	Physiological parameters in laboratory animals and humans.	B Davies, T Morris	Pharm Res	1993	8378254	No
2765	954	954.0	30.2	30.2	The effects of stressful life events on depression.	R C Kessler	Annu Rev Psychol	1997	9046559	No
2766	954	954.0	29.56	29.6	Inhibition of return.	Klein	Trends Cogn Sci	2000	10740278	Yes
2767	954	954.0	24.98	25.0	Differential projections of the infralimbic and prelimbic cortex in the rat.	Robert P Vertes	Synapse	2004	14579424	Yes
2768	953	953.0	46.12	46.1	Biology of interleukin 1.	C A Dinarello	FASEB J	1988	3277884	No
2769	953	953.0	20.75	20.8	Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution.	Z Yang	Mol Biol Evol	1998	9580986	Yes
2770	5718	953.0	233.75	39.0	Antioxidant activity applying an improved ABTS radical cation decolorization assay.	R Re, N Pellegrini, A Proteggente, A Pannala, M Yang, C Rice-Evans	Free Radic Biol Med	1999	10381194	Yes
2771	953	953.0	22.51	22.5	Measuring information transfer	Schreiber	Phys Rev Lett	2000	10991308	Yes
2772	1906	953.0	40.11	20.1	Tumour-cell invasion and migration: diversity and escape mechanisms.	Peter Friedl, Katarina Wolf	Nat Rev Cancer	2003	12724734	No
2773	952	952.0	35.01	35.0	Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology.	J J Gross	J Pers Soc Psychol	1998	9457784	Yes
2774	952	952.0	23.25	23.2	Nonaqueous liquid electrolytes for lithium-based rechargeable batteries.	Kang Xu	Chem Rev	2004	15669157	Yes
2775	952	952.0	0.0	0.0	THE FUNCTION OF THE VERTEBRAL VEINS AND THEIR ROLE IN THE SPREAD OF METASTASES.	O V Batson	Ann Surg	1940	17857618	Yes
2776	951	951.0	0.0	0.0	Regulation of noradrenaline release by presynaptic receptor systems.	K Starke	Rev Physiol Biochem Pharmacol	1977	14389	No
2777	951	951.0	0.0	0.0	Mutation selection and the natural history of cancer.	J Cairns	Nature	1975	1143315	Yes
2778	2853	951.0	84.1	28.0	Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya.	C R Woese, O Kandler, M L Wheelis	Proc Natl Acad Sci U S A	1990	2112744	Yes
2779	951	951.0	48.64	48.6	Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC.	G A McPherson	J Pharmacol Methods	1985	3840547	Yes
2780	951	951.0	26.19	26.2	P-450 metabolites of arachidonic acid in the control of cardiovascular function.	Richard J Roman	Physiol Rev	2002	11773611	No
2781	951	951.0	0.0	0.0	Cellular resistance to infection.	G B MACKANESS	J Exp Med	1962	14467923	Yes
2782	951	951.0	42.29	42.3	The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles.	Eleonore Fröhlich	Int J Nanomedicine	2012	23144561	No
2783	1900	950.0	44.56	22.3	The significance of digital gene expression profiles.	S Audic, J M Claverie	Genome Res	1997	9331369	Yes
2784	1900	950.0	47.12	23.6	Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set.	N Sreerama, R W Woody	Anal Biochem	2000	11112271	Yes
2785	1900	950.0	40.82	20.4	Genomic control for association studies.	B Devlin, K Roeder	Biometrics	1999	11315092	Yes
2786	3800	950.0	103.89	26.0	Functional connectivity in the resting brain: a network analysis of the default mode hypothesis.	Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod Menon	Proc Natl Acad Sci U S A	2003	12506194	Yes
2787	950	950.0	19.84	19.8	mTOR and cancer: insights into a complex relationship.	David M Sabatini	Nat Rev Cancer	2006	16915295	No
2788	950	950.0	36.13	36.1	Amino acids: metabolism, functions, and nutrition.	Guoyao Wu	Amino Acids	2009	19301095	No
2789	1899	949.5	48.85	24.4	Modes of resistance to anti-angiogenic therapy.	Gabriele Bergers, Douglas Hanahan	Nat Rev Cancer	2008	18650835	No
2790	949	949.0	42.39	42.4	Carnitine--metabolism and functions.	J Bremer	Physiol Rev	1983	6361812	No
2791	949	949.0	29.51	29.5	A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors.	Ron Hardman	Environ Health Perspect	2006	16451849	No
2792	949	949.0	83.96	84.0	Understanding Bland Altman analysis.	Davide Giavarina	Biochem Med (Zagreb)	2015	26110027	No
2793	1897	948.5	59.72	29.9	ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control.	Graham Noctor, Christine H. Foyer	Annu Rev Plant Physiol Plant Mol Biol	1998	15012235	Yes
2794	1896	948.0	104.27	52.1	3D bioprinting of tissues and organs.	Sean V Murphy, Anthony Atala	Nat Biotechnol	2014	25093879	Yes
2795	3790	947.5	121.91	30.5	Prevalence and trends in obesity among US adults, 1999-2000.	Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L Johnson	JAMA	2002	12365955	Yes
2796	947	947.0	34.42	34.4	Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.	L A Liotta	Cancer Res	1986	2998604	No
2797	947	947.0	47.29	47.3	Freezing of living cells: mechanisms and implications.	P Mazur	Am J Physiol	1984	6383068	No
2798	947	947.0	21.31	21.3	An overview of epithelio-mesenchymal transformation.	E D Hay	Acta Anat (Basel)	1995	8714286	No
2799	947	947.0	18.24	18.2	Regulatory T cells in autoimmmunity*.	E M Shevach	Annu Rev Immunol	2000	10837065	No
2800	947	947.0	0.0	0.0	Sequential tests for the detection of linkage.	N E MORTON	Am J Hum Genet	1955	13258560	Yes
2801	5682	947.0	138.22	23.0	Principal components analysis corrects for stratification in genome-wide association studies.	Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David Reich	Nat Genet	2006	16862161	Yes
2802	946	946.0	31.85	31.9	General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.	R A Houghten	Proc Natl Acad Sci U S A	1985	2410914	Yes
2803	1892	946.0	162.27	81.1	Facial nerve grading system.	J W House, D E Brackmann	Otolaryngol Head Neck Surg	1985	3921901	Yes
2804	946	946.0	27.44	27.4	Molecular genetics of colorectal cancer.	Eric R Fearon	Annu Rev Pathol	2011	21090969	No
2805	4726	945.2	190.63	38.1	Posttraumatic stress disorder in the National Comorbidity Survey.	R C Kessler, A Sonnega, E Bromet, M Hughes, C B Nelson	Arch Gen Psychiatry	1995	7492257	Yes
2806	945	945.0	36.57	36.6	Diversity and ubiquity of K channels.	B Rudy	Neuroscience	1988	2457185	No
2807	945	945.0	63.73	63.7	Psychosocial resilience and protective mechanisms.	Michael Rutter	Am J Orthopsychiatry	1987	3303954	No
2808	945	945.0	46.68	46.7	Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment.	S H Safe	Crit Rev Toxicol	1994	8037844	No
2809	945	945.0	22.73	22.7	The columnar organization of the neocortex.	V B Mountcastle	Brain	1997	9153131	No
2810	945	945.0	26.6	26.6	Automatic quantitation of localized in vivo 1H spectra with LCModel.	S W Provencher	NMR Biomed	2001	11410943	Yes
2811	945	945.0	0.0	0.0	Starch gel electrophoresis in a discontinous system of buffers.	M D POULIK	Nature	1957	13493570	Yes
2812	945	945.0	26.6	26.6	Electrochemiluminescence (ECL).	Mark M Richter	Chem Rev	2004	15186186	No
2813	5670	945.0	157.11	26.2	An obesity-associated gut microbiome with increased capacity for energy harvest.	Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I Gordon	Nature	2006	17183312	Yes
2814	1888	944.0	55.14	27.6	Molecular mechanisms of action of steroid/thyroid receptor superfamily members.	M J Tsai, B W O'Malley	Annu Rev Biochem	1994	7979245	No
2815	944	944.0	30.1	30.1	Leishmaniasis.	B L Herwaldt	Lancet	1999	10513726	No
2816	944	944.0	35.29	35.3	Apoptosis in cancer: from pathogenesis to treatment.	Rebecca S Y Wong	J Exp Clin Cancer Res	2011	21943236	No
2817	1888	944.0	68.82	34.4	Insights into the regulation of protein abundance from proteomic and transcriptomic analyses.	Christine Vogel, Edward M Marcotte	Nat Rev Genet	2012	22411467	No
2818	3774	943.5	0.0	0.0	The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes.	L A Sternberger, P H Hardy, J J Cuculis, H G Meyer	J Histochem Cytochem	1970	4192899	Yes
2819	1887	943.5	33.84	16.9	A synthetic oscillatory network of transcriptional regulators.	M B Elowitz, S Leibler	Nature	2000	10659856	Yes
2820	1887	943.5	52.73	26.4	Hydrogels for tissue engineering.	K Y Lee, D J Mooney	Chem Rev	2001	11710233	No
2821	943	943.0	0.0	0.0	Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies.	S Avrameas	Immunochemistry	1969	4975324	Yes
2822	943	943.0	33.32	33.3	Spatially heterogeneous dynamics in supercooled liquids.	M D Ediger	Annu Rev Phys Chem	2000	11031277	Yes
2823	943	943.0	24.63	24.6	Solid-state nanopores.	Cees Dekker	Nat Nanotechnol	2007	18654264	No
2824	1885	942.5	71.04	35.5	Origins and evolution of antibiotic resistance.	Julian Davies, Dorothy Davies	Microbiol Mol Biol Rev	2010	20805405	No
2825	2827	942.3	84.06	28.0	A nonparametric method for automatic correction of intensity nonuniformity in MRI data.	J G Sled, A P Zijdenbos, A C Evans	IEEE Trans Med Imaging	1998	9617910	Yes
2826	942	942.0	0.0	0.0	An improved procedure for serum creatine phosphokinase determination.	S B Rosalki	J Lab Clin Med	1967	4381359	Yes
2827	942	942.0	22.9	22.9	Complement. Second of two parts.	M J Walport	N Engl J Med	2001	11297706	No
2828	942	942.0	22.38	22.4	Molecular imaging of cancer with positron emission tomography.	Sanjiv Sam Gambhir	Nat Rev Cancer	2002	12209157	No
2829	942	942.0	82.58	82.6	Making sense of implementation theories, models and frameworks.	Per Nilsen	Implement Sci	2015	25895742	Yes
2830	1883	941.5	45.07	22.5	Regeneration beyond the glial scar.	Jerry Silver, Jared H Miller	Nat Rev Neurosci	2004	14735117	No
2831	941	941.0	34.22	34.2	Understanding diagnostic tests 3: Receiver operating characteristic curves.	Anthony K Akobeng	Acta Paediatr	2007	17376185	No
2832	1882	941.0	124.33	62.2	mTOR Signaling in Growth, Metabolism, and Disease.	Robert A Saxton, David M Sabatini	Cell	2017	28283069	No
2833	4704	940.8	93.23	18.6	The protein kinase complement of the human genome.	G Manning, D B Whyte, R Martinez, T Hunter, S Sudarsanam	Science	2002	12471243	No
2834	2821	940.3	104.96	35.0	Oxidants, antioxidants, and the degenerative diseases of aging.	B N Ames, M K Shigenaga, T M Hagen	Proc Natl Acad Sci U S A	1993	8367443	No
2835	940	940.0	34.96	35.0	The matrix-degrading metalloproteinases.	L M Matrisian	Bioessays	1992	1445287	No
2836	940	940.0	0.0	0.0	Why people use health services.	I M Rosenstock	Milbank Mem Fund Q	1966	5967464	Yes
2837	940	940.0	24.27	24.3	SETOR: hardware-lighted three-dimensional solid model representations of macromolecules.	S V Evans	J Mol Graph	1993	8347566	Yes
2838	940	940.0	39.67	39.7	Physiological implications of hydrogen sulfide: a whiff exploration that blossomed.	Rui Wang	Physiol Rev	2012	22535897	No
2839	1879	939.5	0.0	0.0	A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants.	R L Juliano, V Ling	Biochim Biophys Acta	1976	990323	Yes
2840	939	939.0	62.14	62.1	The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction.	G A Ilizarov	Clin Orthop Relat Res	1989	2912628	Yes
2841	939	939.0	51.48	51.5	Substance P.	B Pernow	Pharmacol Rev	1983	6196797	No
2842	939	939.0	23.84	23.8	Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial.	H J Dargie	Lancet	2001	11356434	Yes
2843	939	939.0	30.14	30.1	Cholinesterase inhibitors for Alzheimer's disease.	J Birks	Cochrane Database Syst Rev	2006	16437532	No
2844	1877	938.5	0.0	0.0	Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran.	R R GUILLARD, J H RYTHER	Can J Microbiol	1962	13902807	Yes
2845	938	938.0	54.78	54.8	A cognitive approach to panic.	D M Clark	Behav Res Ther	1986	3741311	Yes
2846	938	938.0	0.0	0.0	Studies on phosphatidylcholine vesicles. Formation and physical characteristics.	C Huang	Biochemistry	1969	5777332	Yes
2847	1875	937.5	65.07	32.5	Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report.	P Brugada, J Brugada	J Am Coll Cardiol	1992	1309182	Yes
2848	1875	937.5	60.95	30.5	Heterogeneous photocatalyst materials for water splitting.	Akihiko Kudo, Yugo Miseki	Chem Soc Rev	2009	19088977	Yes
2849	1874	937.0	43.06	21.5	Checkpoints: controls that ensure the order of cell cycle events.	L H Hartwell, T A Weinert	Science	1989	2683079	No
2850	937	937.0	22.41	22.4	The tumor microenvironment and its role in promoting tumor growth.	T L Whiteside	Oncogene	2008	18836471	No
2851	3747	936.8	104.51	26.1	An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets.	Joseph A Maldjian, Paul J Laurienti, Robert A Kraft, Jonathan H Burdette	Neuroimage	2003	12880848	Yes
2852	1873	936.5	98.56	49.3	Biology of disease: free radicals and tissue injury.	B A Freeman, J D Crapo	Lab Invest	1982	6290784	No
2853	1873	936.5	42.99	21.5	Dynamic instability of microtubule growth.	T Mitchison, M Kirschner	Nature	1984	6504138	Yes
2854	936	936.0	27.47	27.5	Two-stage model of memory trace formation: a role for "noisy" brain states.	G Buzsáki	Neuroscience	1989	2687720	No
2855	936	936.0	28.6	28.6	Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes.	M Kozak	Nucleic Acids Res	1981	7301588	Yes
2856	936	936.0	32.86	32.9	Context, time, and memory retrieval in the interference paradigms of Pavlovian learning.	M E Bouton	Psychol Bull	1993	8346330	No
2857	936	936.0	0.0	0.0	Simple methods for "staining with lead" at high pH in electron microscopy.	M J KARNOVSKY	J Biophys Biochem Cytol	1961	14454024	Yes
2858	1871	935.5	48.55	24.3	Inflammation, stress, and diabetes.	Kathryn E Wellen, Gökhan S Hotamisligil	J Clin Invest	2005	15864338	No
2859	9355	935.5	236.65	23.7	Scalable molecular dynamics with NAMD.	James C Phillips, Rosemary Braun, Wei Wang, James Gumbart, Emad Tajkhorshid, Elizabeth Villa, Christophe Chipot, Robert D Skeel, Laxmikant Kalé, Klaus Schulten	J Comput Chem	2005	16222654	Yes
2860	1871	935.5	44.22	22.1	Regulation of translation initiation in eukaryotes: mechanisms and biological targets.	Nahum Sonenberg, Alan G Hinnebusch	Cell	2009	19239892	No
2861	935	935.0	21.51	21.5	Oxidant signals and oxidative stress.	Toren Finkel	Curr Opin Cell Biol	2003	12648682	No
2862	1869	934.5	55.12	27.6	Oxidative stress, caloric restriction, and aging.	R S Sohal, R Weindruch	Science	1996	8658196	No
2863	3736	934.0	133.92	33.5	Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.	N Weidner, J P Semple, W R Welch, J Folkman	N Engl J Med	1991	1701519	Yes
2864	934	934.0	0.0	0.0	Origin of concatemeric T7 DNA.	J D Watson	Nat New Biol	1972	4507727	Yes
2865	934	934.0	0.0	0.0	The prevalence of 'alexithymic' characteristics in psychosomatic patients.	P E Sifneos	Psychother Psychosom	1973	4770536	Yes
2866	934	934.0	23.63	23.6	ALSCRIPT: a tool to format multiple sequence alignments.	G J Barton	Protein Eng	1993	8433969	Yes
2867	933	933.0	42.23	42.2	The P300 wave of the human event-related potential.	T W Picton	J Clin Neurophysiol	1992	1464675	No
2868	1866	933.0	54.34	27.2	Protein oxidation in aging, disease, and oxidative stress.	B S Berlett, E R Stadtman	J Biol Chem	1997	9252331	No
2869	3732	933.0	105.65	26.4	C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women.	P M Ridker, C H Hennekens, J E Buring, N Rifai	N Engl J Med	2000	10733371	Yes
2870	933	933.0	19.94	19.9	VEGF and the quest for tumour angiogenesis factors.	Napoleone Ferrara	Nat Rev Cancer	2002	12360282	No
2871	933	933.0	25.91	25.9	Looking into the functional architecture of the brain with diffusion MRI.	Denis Le Bihan	Nat Rev Neurosci	2003	12778119	No
2872	933	933.0	20.53	20.5	Fibrotic disease and the T(H)1/T(H)2 paradigm.	Thomas A Wynn	Nat Rev Immunol	2004	15286725	No
2873	933	933.0	19.49	19.5	Telomeres and human disease: ageing, cancer and beyond.	Maria A Blasco	Nat Rev Genet	2005	16136653	No
2874	1865	932.5	56.76	28.4	BODIPY dyes and their derivatives: syntheses and spectroscopic properties.	Aurore Loudet, Kevin Burgess	Chem Rev	2007	17924696	Yes
2875	932	932.0	0.0	0.0	Avidin.	N M Green	Adv Protein Chem	1975	237414	Yes
2876	932	932.0	28.75	28.8	The mitochondrial electron transport and oxidative phosphorylation system.	Y Hatefi	Annu Rev Biochem	1985	2862839	No
2877	1864	932.0	42.98	21.5	The Hsp70 and Hsp60 chaperone machines.	B Bukau, A L Horwich	Cell	1998	9476895	No
2878	932	932.0	28.37	28.4	Epidemiology of women and depression.	Ronald C Kessler	J Affect Disord	2003	12646294	Yes
2879	931	931.0	30.03	30.0	Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.	J Deisenhofer	Biochemistry	1981	7236608	Yes
2880	1861	930.5	49.56	24.8	A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure.	J N Cohn, G Tognoni	N Engl J Med	2001	11759645	Yes
2881	1861	930.5	43.58	21.8	Deep tissue two-photon microscopy.	Fritjof Helmchen, Winfried Denk	Nat Methods	2005	16299478	No
2882	1860	930.0	0.0	0.0	Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome.	C B Lozzio, B B Lozzio	Blood	1975	163658	Yes
2883	1860	930.0	75.74	37.9	Unidentified curved bacilli on gastric epithelium in active chronic gastritis.	J R Warren, B Marshall	Lancet	1983	6134060	Yes
2884	930	930.0	22.47	22.5	MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation.	R N Germain	Cell	1994	8293464	No
2885	929	929.0	0.0	0.0	Method for the determination of hexosamines in tissues.	N F BOAS	J Biol Chem	1953	13117829	Yes
2886	929	929.0	21.98	22.0	Hypoxia, HIF1 and glucose metabolism in the solid tumour.	Nicholas C Denko	Nat Rev Cancer	2008	19143055	No
2887	1858	929.0	63.01	31.5	Strategies in the design of nanoparticles for therapeutic applications.	Robby A Petros, Joseph M DeSimone	Nat Rev Drug Discov	2010	20616808	No
2888	2786	928.7	91.04	30.3	A sensitive and reliable locomotor rating scale for open field testing in rats.	D M Basso, M S Beattie, J C Bresnahan	J Neurotrauma	1995	7783230	Yes
2889	1856	928.0	59.58	29.8	Ageing and Parkinson's disease: substantia nigra regional selectivity.	J M Fearnley, A J Lees	Brain	1991	1933245	Yes
2890	928	928.0	23.51	23.5	The prefrontal cortex--an update: time is of the essence.	J M Fuster	Neuron	2001	11394996	No
2891	928	928.0	29.6	29.6	Disseminating innovations in health care.	Donald M Berwick	JAMA	2003	12697800	Yes
2892	2782	927.3	185.64	61.9	Some statistical methods useful in circulation research.	S Wallenstein, C L Zucker, J L Fleiss	Circ Res	1980	7379260	Yes
2893	927	927.0	29.49	29.5	Pathogenesis of dengue: challenges to molecular biology.	S B Halstead	Science	1988	3277268	No
2894	927	927.0	35.01	35.0	Effect of anoxia on ion distribution in the brain.	A J Hansen	Physiol Rev	1985	3880896	No
2895	927	927.0	23.15	23.1	PHD: predicting one-dimensional protein structure by profile-based neural networks.	B Rost	Methods Enzymol	1996	8743704	Yes
2896	927	927.0	29.66	29.7	Limbic-cortical dysregulation: a proposed model of depression.	H S Mayberg	J Neuropsychiatry Clin Neurosci	1997	9276848	No
2897	927	927.0	18.35	18.4	The ubiquitin-proteasome pathway: on protein death and cell life.	A Ciechanover	EMBO J	1998	9857172	No
2898	927	927.0	30.3	30.3	Riddle of biofilm resistance.	K Lewis	Antimicrob Agents Chemother	2001	11257008	No
2899	927	927.0	27.06	27.1	TNF-mediated inflammatory disease.	J R Bradley	J Pathol	2008	18161752	No
2900	1853	926.5	68.01	34.0	DPARSF: A MATLAB Toolbox for "Pipeline" Data Analysis of Resting-State fMRI.	Yan Chao-Gan, Zang Yu-Feng	Front Syst Neurosci	2010	20577591	Yes
2901	926	926.0	41.28	41.3	A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes.	S T Tiffany	Psychol Rev	1990	2186423	No
2902	926	926.0	57.39	57.4	The clinical application of the biopsychosocial model.	G L Engel	Am J Psychiatry	1980	7369396	Yes
2903	926	926.0	27.71	27.7	The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices.	R A Jain	Biomaterials	2000	11055295	No
2904	926	926.0	0.0	0.0	The generalisation of student's problems when several different population variances are involved.	B L WELCH	Biometrika	1947	20287819	Yes
2905	926	926.0	39.45	39.5	The role of senescent cells in ageing.	Jan M van Deursen	Nature	2014	24848057	No
2906	926	926.0	82.74	82.7	Metazoan MicroRNAs.	David P Bartel	Cell	2018	29570994	No
2907	2777	925.7	69.68	23.2	Photodynamic therapy for cancer.	Dennis E J G J Dolmans, Dai Fukumura, Rakesh K Jain	Nat Rev Cancer	2003	12724736	No
2908	1851	925.5	68.67	34.3	Stochastic relaxation, gibbs distributions, and the bayesian restoration of images.	S Geman, D Geman	IEEE Trans Pattern Anal Mach Intell	1984	22499653	Yes
2909	2776	925.3	90.43	30.1	Spirometric reference values from a sample of the general U.S. population.	J L Hankinson, J R Odencrantz, K B Fedan	Am J Respir Crit Care Med	1999	9872837	Yes
2910	1850	925.0	58.51	29.3	Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications.	M A Pfeffer, E Braunwald	Circulation	1990	2138525	No
2911	3700	925.0	104.33	26.1	Universal sample preparation method for proteome analysis.	Jacek R Wiśniewski, Alexandre Zougman, Nagarjuna Nagaraj, Matthias Mann	Nat Methods	2009	19377485	Yes
2912	3699	924.8	113.23	28.3	Measurement of the elastic properties and intrinsic strength of monolayer graphene.	Changgu Lee, Xiaoding Wei, Jeffrey W Kysar, James Hone	Science	2008	18635798	Yes
2913	5547	924.5	235.11	39.2	The occurrence of sleep-disordered breathing among middle-aged adults.	T Young, M Palta, J Dempsey, J Skatrud, S Weber, S Badr	N Engl J Med	1993	8464434	Yes
2914	1848	924.0	0.0	0.0	Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice.	J D McGhee, P H von Hippel	J Mol Biol	1974	4416620	Yes
2915	1848	924.0	43.07	21.5	Roles of CHOP/GADD153 in endoplasmic reticulum stress.	S Oyadomari, M Mori	Cell Death Differ	2004	14685163	No
2916	924	924.0	24.98	25.0	Nitric oxide, oxidants, and protein tyrosine nitration.	Rafael Radi	Proc Natl Acad Sci U S A	2004	15020765	Yes
2917	923	923.0	0.0	0.0	Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action.	J H Luft	Anat Rec	1971	4108333	Yes
2918	1846	923.0	0.0	0.0	A rapid, sensitive, and specific method for the determination of protein in dilute solution.	W Schaffner, C Weissmann	Anal Biochem	1973	4128882	Yes
2919	923	923.0	40.87	40.9	Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants.	R W Bohannon	Age Ageing	1997	9143432	Yes
2920	923	923.0	21.93	21.9	GLIA: listening and talking to the synapse.	P G Haydon	Nat Rev Neurosci	2001	11256079	No
2921	923	923.0	37.33	37.3	How stigma interferes with mental health care.	Patrick Corrigan	Am Psychol	2004	15491256	Yes
2922	923	923.0	17.73	17.7	NFAT proteins: key regulators of T-cell development and function.	Fernando Macian	Nat Rev Immunol	2005	15928679	No
2923	1845	922.5	63.93	32.0	Physiological time-series analysis using approximate entropy and sample entropy.	J S Richman, J R Moorman	Am J Physiol Heart Circ Physiol	2000	10843903	Yes
2924	1845	922.5	43.7	21.9	microRNA functions.	Natascha Bushati, Stephen M Cohen	Annu Rev Cell Dev Biol	2007	17506695	No
2925	922	922.0	0.0	0.0	Cell lines derived from late embryonic stages of Drosophila melanogaster.	I Schneider	J Embryol Exp Morphol	1972	4625067	Yes
2926	1844	922.0	49.06	24.5	Hepatitis C virus infection.	G M Lauer, B D Walker	N Engl J Med	2001	11439948	No
2927	1844	922.0	51.85	25.9	Epidemiology of Parkinson's disease.	Lonneke M L de Lau, Monique M B Breteler	Lancet Neurol	2006	16713924	No
2928	922	922.0	29.45	29.4	Species concepts and species delimitation.	Kevin De Queiroz	Syst Biol	2007	18027281	Yes
2929	1842	921.0	69.71	34.9	Population growth makes waves in the distribution of pairwise genetic differences.	A R Rogers, H Harpending	Mol Biol Evol	1992	1316531	Yes
2930	921	921.0	22.61	22.6	BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data.	O Gascuel	Mol Biol Evol	1997	9254330	Yes
2931	921	921.0	24.12	24.1	Seed Germination and Dormancy.	J. D. Bewley	Plant Cell	1997	12237375	Yes
2932	921	921.0	0.0	0.0	The relation of the trail making test to organic brain damage.	R M REITAN	J Consult Psychol	1955	13263471	Yes
2933	5525	920.8	195.55	32.6	Prevalence of overweight and obesity in the United States, 1999-2004.	Cynthia L Ogden, Margaret D Carroll, Lester R Curtin, Margaret A McDowell, Carolyn J Tabak, Katherine M Flegal	JAMA	2006	16595758	Yes
2934	1841	920.5	29.63	14.8	Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis.	T Lee, L Luo	Neuron	1999	10197526	Yes
2935	1841	920.5	45.44	22.7	Shape-controlled synthesis of gold and silver nanoparticles.	Yugang Sun, Younan Xia	Science	2002	12481134	Yes
2936	8283	920.3	252.46	28.1	MolProbity: all-atom structure validation for macromolecular crystallography.	Vincent B Chen, W Bryan Arendall, Jeffrey J Headd, Daniel A Keedy, Robert M Immormino, Gary J Kapral, Laura W Murray, Jane S Richardson, David C Richardson	Acta Crystallogr D Biol Crystallogr	2010	20057044	Yes
2937	920	920.0	0.0	0.0	Structure and function of intercellular junctions.	L A Staehelin	Int Rev Cytol	1974	4611943	No
2938	920	920.0	116.74	116.7	The analysis of errors in orthodontic measurements.	W J Houston	Am J Orthod	1983	6573846	Yes
2939	920	920.0	0.0	0.0	The anterior approach for removal of ruptured cervical disks.	R B CLOWARD	J Neurosurg	1958	13599052	Yes
2940	2758	919.3	147.91	49.3	Scoping studies: advancing the methodology.	Danielle Levac, Heather Colquhoun, Kelly K O'Brien	Implement Sci	2010	20854677	Yes
2941	919	919.0	25.62	25.6	Chemistry and biology of the immunophilins and their immunosuppressive ligands.	S L Schreiber	Science	1991	1702904	No
2942	919	919.0	25.17	25.2	Life, death, and the pursuit of apoptosis.	E White	Genes Dev	1996	8557188	No
2943	919	919.0	17.25	17.2	TNF/TNFR family members in costimulation of T cell responses.	Tania H Watts	Annu Rev Immunol	2005	15771565	No
2944	919	919.0	25.45	25.4	Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis.	Peter Fransson	Hum Brain Mapp	2005	15852468	Yes
2945	919	919.0	0.0	0.0	A simple objective technique for measuring flexibility in thinking.	E A BERG	J Gen Psychol	1948	18889466	Yes
2946	919	919.0	31.56	31.6	G(ST) and its relatives do not measure differentiation.	Lou Jost	Mol Ecol	2008	19238703	Yes
2947	1837	918.5	49.78	24.9	Prediction of protein secondary structure at better than 70% accuracy.	B Rost, C Sander	J Mol Biol	1993	8345525	Yes
2948	918	918.0	40.63	40.6	Spatial localization in NMR spectroscopy in vivo.	P A Bottomley	Ann N Y Acad Sci	1987	3326459	No
2949	1836	918.0	44.75	22.4	Long-term potentiation--a decade of progress?	R C Malenka, R A Nicoll	Science	1999	10489359	No
2950	918	918.0	31.89	31.9	Reducing children's television viewing to prevent obesity: a randomized controlled trial.	T N Robinson	JAMA	1999	10546696	Yes
2951	918	918.0	19.36	19.4	Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.	A S Baldwin	J Clin Invest	2001	11160144	No
2952	918	918.0	28.26	28.3	Akaike's information criterion in generalized estimating equations.	W Pan	Biometrics	2001	11252586	Yes
2953	918	918.0	0.0	0.0	Relative and absolute strength of response as a function of frequency of reinforcement.	R J HERRNSTEIN	J Exp Anal Behav	1961	13713775	Yes
2954	918	918.0	30.64	30.6	Insecticide-treated bed nets and curtains for preventing malaria.	C Lengeler	Cochrane Database Syst Rev	2004	15106149	No
2955	918	918.0	43.53	43.5	A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading.	Cathy J Price	Neuroimage	2012	22584224	No
2956	2753	917.7	89.16	29.7	Regulation of cancer cell metabolism.	Rob A Cairns, Isaac S Harris, Tak W Mak	Nat Rev Cancer	2011	21258394	No
2957	1835	917.5	37.58	18.8	Wnt signaling: a common theme in animal development.	K M Cadigan, R Nusse	Genes Dev	1997	9407023	No
2958	917	917.0	31.82	31.8	Qinghaosu (artemisinin): an antimalarial drug from China.	D L Klayman	Science	1985	3887571	No
2959	916	916.0	42.06	42.1	Transduction of psychosocial stress into the neurobiology of recurrent affective disorder.	R M Post	Am J Psychiatry	1992	1353322	No
2960	916	916.0	33.89	33.9	The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.	R G Gerrity	Am J Pathol	1981	7234961	Yes
2961	1832	916.0	43.81	21.9	Mitogen-activated protein kinase pathways.	M J Robinson, M H Cobb	Curr Opin Cell Biol	1997	9069255	No
2962	916	916.0	22.72	22.7	New ideas about atrial fibrillation 50 years on.	Stanley Nattel	Nature	2002	11805846	No
2963	916	916.0	30.1	30.1	Regulation of glutathione synthesis.	Shelly C Lu	Mol Aspects Med	2009	18601945	No
2964	2747	915.7	64.82	21.6	Generation of germline-competent induced pluripotent stem cells.	Keisuke Okita, Tomoko Ichisaka, Shinya Yamanaka	Nature	2007	17554338	Yes
2965	1831	915.5	66.98	33.5	The reward circuit: linking primate anatomy and human imaging.	Suzanne N Haber, Brian Knutson	Neuropsychopharmacology	2010	19812543	No
2966	915	915.0	0.0	0.0	6-Hydroxy-dopamine induced degeneration of central monoamine neurons.	U Ungerstedt	Eur J Pharmacol	1968	5718510	Yes
2967	915	915.0	23.85	23.9	Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes.	J Denis McGarry	Diabetes	2002	11756317	No
2968	2745	915.0	95.59	31.9	Health benefits of physical activity: the evidence.	Darren E R Warburton, Crystal Whitney Nicol, Shannon S D Bredin	CMAJ	2006	16534088	No
2969	915	915.0	64.12	64.1	Abiotic Stress Signaling and Responses in Plants.	Jian-Kang Zhu	Cell	2016	27716505	No
2970	4572	914.4	147.18	29.4	Quantitative assessment of tactile allodynia in the rat paw.	S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L Yaksh	J Neurosci Methods	1994	7990513	Yes
2971	1828	914.0	85.69	42.8	Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal.	H Esterbauer, K H Cheeseman	Methods Enzymol	1990	2233308	Yes
2972	1828	914.0	46.97	23.5	Regulation of wound healing by growth factors and cytokines.	Sabine Werner, Richard Grose	Physiol Rev	2003	12843410	No
2973	1828	914.0	51.42	25.7	An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance.	Gary Aston-Jones, Jonathan D Cohen	Annu Rev Neurosci	2005	16022602	No
2974	914	914.0	49.36	49.4	The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults.	L S Radloff	J Youth Adolesc	1991	24265004	Yes
2975	913	913.0	57.22	57.2	A "rationalized" arcsine transform.	G A Studebaker	J Speech Hear Res	1985	4046587	Yes
2976	913	913.0	26.88	26.9	The Trk family of neurotrophin receptors.	M Barbacid	J Neurobiol	1994	7852993	No
2977	1826	913.0	63.39	31.7	Excitatory amino acids as a final common pathway for neurologic disorders.	S A Lipton, P A Rosenberg	N Engl J Med	1994	7905600	No
2978	913	913.0	17.95	17.9	Chronic myeloid leukemia.	C L Sawyers	N Engl J Med	1999	10219069	No
2979	1826	913.0	77.51	38.8	Pharmaceuticals and personal care products in the environment: agents of subtle change?	C G Daughton, T A Ternes	Environ Health Perspect	1999	10592150	No
2980	3652	913.0	99.98	25.0	The epidemiology of sepsis in the United States from 1979 through 2000.	Greg S Martin, David M Mannino, Stephanie Eaton, Marc Moss	N Engl J Med	2003	12700374	Yes
2981	1826	913.0	0.0	0.0	Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies.	H A EDMONDSON, P E STEINER	Cancer	1954	13160935	Yes
2982	913	913.0	30.12	30.1	Atomic layer deposition: an overview.	Steven M George	Chem Rev	2010	19947596	Yes
2983	8215	912.8	236.3	26.3	Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation.	Cole Trapnell, Brian A Williams, Geo Pertea, Ali Mortazavi, Gordon Kwan, Marijke J van Baren, Steven L Salzberg, Barbara J Wold, Lior Pachter	Nat Biotechnol	2010	20436464	Yes
2984	4562	912.4	183.43	36.7	Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.	J S Beckman, T W Beckman, J Chen, P A Marshall, B A Freeman	Proc Natl Acad Sci U S A	1990	2154753	Yes
2985	5474	912.3	163.43	27.2	Prediction of coronary heart disease using risk factor categories.	P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B Kannel	Circulation	1998	9603539	Yes
2986	1824	912.0	40.98	20.5	Homeobox genes and axial patterning.	W McGinnis, R Krumlauf	Cell	1992	1346368	No
2987	1824	912.0	56.63	28.3	A new local density functional for main-group thermochemistry, transition metal bonding, thermochemical kinetics, and noncovalent interactions.	Yan Zhao, Donald G Truhlar	J Chem Phys	2006	17129083	Yes
2988	912	912.0	24.45	24.4	Transcriptional paradigms in mammalian mitochondrial biogenesis and function.	Richard C Scarpulla	Physiol Rev	2008	18391175	No
2989	912	912.0	23.48	23.5	Principles and challenges of genomewide DNA methylation analysis.	Peter W Laird	Nat Rev Genet	2010	20125086	No
2990	1824	912.0	76.95	38.5	Catalytic dehydrogenative cross-coupling: forming carbon-carbon bonds by oxidizing two carbon-hydrogen bonds.	Charles S Yeung, Vy M Dong	Chem Rev	2011	21391561	Yes
2991	911	911.0	31.94	31.9	Animal mitochondrial DNA: structure and evolution.	D R Wolstenholme	Int Rev Cytol	1992	1452431	No
2992	911	911.0	19.11	19.1	Initiation of translation in prokaryotes and eukaryotes.	M Kozak	Gene	1999	10395892	No
2993	911	911.0	39.54	39.5	A review of psychological risk factors in back and neck pain.	S J Linton	Spine (Phila Pa 1976)	2000	10788861	No
2994	911	911.0	0.0	0.0	A production of amino acids under possible primitive earth conditions.	S L MILLER	Science	1953	13056598	Yes
2995	911	911.0	0.0	0.0	Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig.	G D WINTER	Nature	1962	14007593	Yes
2996	911	911.0	23.81	23.8	Perylene bisimide dyes as versatile building blocks for functional supramolecular architectures.	Frank Würthner	Chem Commun (Camb)	2004	15263926	Yes
2997	911	911.0	25.42	25.4	Targeting DNA topoisomerase II in cancer chemotherapy.	John L Nitiss	Nat Rev Cancer	2009	19377506	No
2998	911	911.0	28.47	28.5	AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function.	D Grahame Hardie	Genes Dev	2011	21937710	No
2999	911	911.0	43.85	43.9	Exploring Structure-Activity Data Using the Landscape Paradigm.	Rajarshi Guha	Wiley Interdiscip Rev Comput Mol Sci	2012	24163705	Yes
3000	910	910.0	39.07	39.1	The phenomenon of the acute phase response.	I Kushner	Ann N Y Acad Sci	1982	7046585	No
3001	1820	910.0	52.96	26.5	The protective effects of estrogen on the cardiovascular system.	M E Mendelsohn, R H Karas	N Engl J Med	1999	10362825	No
3002	910	910.0	24.22	24.2	Quantification of beta-sheet amyloid fibril structures with thioflavin T.	H LeVine	Methods Enzymol	1999	10507030	Yes
3003	910	910.0	21.84	21.8	Epstein-Barr virus infection.	J I Cohen	N Engl J Med	2000	10944566	No
3004	1819	909.5	94.42	47.2	Rapid procedure for detection and isolation of large and small plasmids.	C I Kado, S T Liu	J Bacteriol	1981	7009583	Yes
3005	1819	909.5	53.08	26.5	Humans integrate visual and haptic information in a statistically optimal fashion.	Marc O Ernst, Martin S Banks	Nature	2002	11807554	Yes
3006	909	909.0	43.13	43.1	Geriatric Depression Scale.	J A Yesavage	Psychopharmacol Bull	1988	3249773	Yes
3007	909	909.0	62.78	62.8	Rating scales to assess depression in school-aged children.	M Kovacs	Acta Paedopsychiatr	1981	7025571	Yes
3008	1818	909.0	67.87	33.9	LigPlot+: multiple ligand-protein interaction diagrams for drug discovery.	Roman A Laskowski, Mark B Swindells	J Chem Inf Model	2011	21919503	Yes
3009	908	908.0	25.55	25.6	Pathogenesis of osteoporosis: concepts, conflicts, and prospects.	Lawrence G Raisz	J Clin Invest	2005	16322775	No
3010	908	908.0	27.42	27.4	Production and scavenging of reactive oxygen species in chloroplasts and their functions.	Kozi Asada	Plant Physiol	2006	16760493	Yes
3011	1815	907.5	33.48	16.7	Effective targeted gene 'knockdown' in zebrafish.	A Nasevicius, S C Ekker	Nat Genet	2000	11017081	Yes
3012	1815	907.5	38.76	19.4	Of mice and not men: differences between mouse and human immunology.	Javier Mestas, Christopher C W Hughes	J Immunol	2004	14978070	No
3013	907	907.0	54.03	54.0	Analysis of Fickian and non-Fickian drug release from polymers.	N A Peppas	Pharm Acta Helv	1985	4011621	Yes
3014	907	907.0	0.0	0.0	Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion.	P O Seglen	Exp Cell Res	1973	4358115	Yes
3015	907	907.0	0.0	0.0	Stimulus-secretion coupling: the concept and clues from chromaffin and other cells.	W W Douglas	Br J Pharmacol	1968	4882190	No
3016	907	907.0	0.0	0.0	Strategy and tactics in protein chemistry.	B S Hartley	Biochem J	1970	4923920	No
3017	2721	907.0	122.06	40.7	Neighborhoods and violent crime: a multilevel study of collective efficacy.	R J Sampson, S W Raudenbush, F Earls	Science	1997	9252316	Yes
3018	907	907.0	29.38	29.4	Pharmacology of cannabinoid CB1 and CB2 receptors.	R G Pertwee	Pharmacol Ther	1997	9336020	No
3019	907	907.0	29.54	29.5	On the utility of P3 amplitude as a measure of processing capacity.	A Kok	Psychophysiology	2001	11352145	No
3020	907	907.0	28.67	28.7	Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity.	F P Guengerich	Chem Res Toxicol	2001	11409933	No
3021	907	907.0	0.0	0.0	A Protection Motivation Theory of Fear Appeals and Attitude Change1.	Ronald W Rogers	J Psychol	1975	28136248	Yes
3022	2720	906.7	81.07	27.0	trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses.	Salvador Capella-Gutiérrez, José M Silla-Martínez, Toni Gabaldón	Bioinformatics	2009	19505945	Yes
3023	1813	906.5	38.54	19.3	Cellular functions regulated by Src family kinases.	S M Thomas, J S Brugge	Annu Rev Cell Dev Biol	1997	9442882	No
3024	1813	906.5	87.73	43.9	Liposomal drug delivery systems: from concept to clinical applications.	Theresa M Allen, Pieter R Cullis	Adv Drug Deliv Rev	2013	23036225	No
3025	5438	906.3	158.05	26.3	The capsaicin receptor: a heat-activated ion channel in the pain pathway.	M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D Julius	Nature	1997	9349813	Yes
3026	906	906.0	22.08	22.1	Nucleic acid junctions and lattices.	N C Seeman	J Theor Biol	1982	6188926	Yes
3027	2718	906.0	172.14	57.4	Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines.	F Guillemin, C Bombardier, D Beaton	J Clin Epidemiol	1993	8263569	No
3028	906	906.0	23.78	23.8	Current concepts of the pathogenesis of the acute coronary syndromes.	P Libby	Circulation	2001	11457759	No
3029	906	906.0	25.78	25.8	Mode of action of membrane active antimicrobial peptides.	Yechiel Shai	Biopolymers	2002	12491537	No
3030	2717	905.7	55.11	18.4	Exosomes: composition, biogenesis and function.	Clotilde Théry, Laurence Zitvogel, Sebastian Amigorena	Nat Rev Immunol	2002	12154376	No
3031	3622	905.5	102.55	25.6	MEGA2: molecular evolutionary genetics analysis software.	S Kumar, K Tamura, I B Jakobsen, M Nei	Bioinformatics	2001	11751241	Yes
3032	1811	905.5	37.1	18.6	The druggable genome.	Andrew L Hopkins, Colin R Groom	Nat Rev Drug Discov	2002	12209152	No
3033	905	905.0	20.85	20.9	Fluorescence spectroscopy of single biomolecules.	S Weiss	Science	1999	10073925	No
3034	1810	905.0	36.67	18.3	AP-1 as a regulator of cell life and death.	Eitan Shaulian, Michael Karin	Nat Cell Biol	2002	11988758	No
3035	905	905.0	29.58	29.6	Targeting recovery: priorities of the spinal cord-injured population.	Kim D Anderson	J Neurotrauma	2004	15672628	Yes
3036	905	905.0	22.54	22.5	A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage.	Lawrence Steinman	Nat Med	2007	17290272	No
3037	1810	905.0	46.49	23.2	Establishing, maintaining and modifying DNA methylation patterns in plants and animals.	Julie A Law, Steven E Jacobsen	Nat Rev Genet	2010	20142834	No
3038	1809	904.5	65.3	32.6	Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.	J L Weber, P E May	Am J Hum Genet	1989	2916582	Yes
3039	1809	904.5	37.14	18.6	CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production.	A M Thornton, E M Shevach	J Exp Med	1998	9670041	Yes
3040	5425	904.2	129.43	21.6	Obesity is associated with macrophage accumulation in adipose tissue.	Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W Ferrante	J Clin Invest	2003	14679176	Yes
3041	904	904.0	67.48	67.5	Calcium phosphate ceramics as hard tissue prosthetics.	M Jarcho	Clin Orthop Relat Res	1981	7018783	No
3042	904	904.0	29.66	29.7	Ion suppression in mass spectrometry.	Thomas M Annesley	Clin Chem	2003	12816898	No
3043	904	904.0	19.22	19.2	The evolutionary significance of cis-regulatory mutations.	Gregory A Wray	Nat Rev Genet	2007	17304246	No
3044	1807	903.5	38.9	19.4	Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm.	P E Wright, H J Dyson	J Mol Biol	1999	10550212	No
3045	2709	903.0	0.0	0.0	Depression: a new animal model sensitive to antidepressant treatments.	R D Porsolt, M Le Pichon, M Jalfre	Nature	1977	559941	Yes
3046	903	903.0	34.81	34.8	Sensorimotor integration in human postural control.	R J Peterka	J Neurophysiol	2002	12205132	Yes
3047	903	903.0	21.69	21.7	The state of lipid rafts: from model membranes to cells.	Michael Edidin	Annu Rev Biophys Biomol Struct	2003	12543707	No
3048	903	903.0	0.0	0.0	Antigen-antibody reactions in gels.	O OUCHTERLONY	Acta Pathol Microbiol Scand	1949	18143039	Yes
3049	2707	902.3	109.4	36.5	The 'Trier Social Stress Test'--a tool for investigating psychobiological stress responses in a laboratory setting.	C Kirschbaum, K M Pirke, D H Hellhammer	Neuropsychobiology	1993	8255414	Yes
3050	2707	902.3	77.8	25.9	Use and abuse of HOMA modeling.	Tara M Wallace, Jonathan C Levy, David R Matthews	Diabetes Care	2004	15161807	No
3051	902	902.0	18.64	18.6	Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins.	M D Resh	Biochim Biophys Acta	1999	10446384	No
3052	1804	902.0	44.83	22.4	Obesity and insulin resistance.	B B Kahn, J S Flier	J Clin Invest	2000	10953022	No
3053	902	902.0	16.71	16.7	The anaphase promoting complex/cyclosome: a machine designed to destroy.	Jan-Michael Peters	Nat Rev Mol Cell Biol	2006	16896351	No
3054	1803	901.5	45.82	22.9	A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli.	C S Hoffman, F Winston	Gene	1987	3319781	Yes
3055	901	901.0	25.35	25.4	Tumor suppressor genes.	R A Weinberg	Science	1991	1659741	No
3056	901	901.0	19.13	19.1	Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution.	Mats G L Gustafsson	Proc Natl Acad Sci U S A	2005	16141335	Yes
3057	901	901.0	33.52	33.5	Clinical practice. Endometriosis.	Linda C Giudice	N Engl J Med	2010	20573927	No
3058	1801	900.5	33.02	16.5	Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain.	W Gu, R G Roeder	Cell	1997	9288740	Yes
3059	1801	900.5	55.26	27.6	Fitness effects on the cognitive function of older adults: a meta-analytic study.	Stanley Colcombe, Arthur F Kramer	Psychol Sci	2003	12661673	Yes
3060	1801	900.5	51.88	25.9	Recent developments in the MAFFT multiple sequence alignment program.	Kazutaka Katoh, Hiroyuki Toh	Brief Bioinform	2008	18372315	Yes
3061	900	900.0	29.0	29.0	Presynaptic nicotinic ACh receptors.	S Wonnacott	Trends Neurosci	1997	9023878	No
3062	900	900.0	36.05	36.0	Predictors of postpartum depression: an update.	C T Beck	Nurs Res	2001	11570712	Yes
3063	900	900.0	19.61	19.6	Models, mechanisms and clinical evidence for cancer dormancy.	Julio A Aguirre-Ghiso	Nat Rev Cancer	2007	17957189	No
3064	2699	899.7	77.01	25.7	The widespread regulation of microRNA biogenesis, function and decay.	Jacek Krol, Inga Loedige, Witold Filipowicz	Nat Rev Genet	2010	20661255	No
3065	1799	899.5	71.58	35.8	Role of oxidized low density lipoprotein in atherogenesis.	J L Witztum, D Steinberg	J Clin Invest	1991	1752940	No
3066	1799	899.5	38.16	19.1	Convergence of Wnt, beta-catenin, and cadherin pathways.	W James Nelson, Roel Nusse	Science	2004	15001769	No
3067	1798	899.0	45.71	22.9	Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133.	G A Gonzalez, M R Montminy	Cell	1989	2573431	Yes
3068	899	899.0	18.38	18.4	The lasso method for variable selection in the Cox model.	R Tibshirani	Stat Med	1997	9044528	Yes
3069	899	899.0	23.27	23.3	Aptamers: an emerging class of molecules that rival antibodies in diagnostics.	S D Jayasena	Clin Chem	1999	10471678	No
3070	1798	899.0	48.18	24.1	Quorum sensing: cell-to-cell communication in bacteria.	Christopher M Waters, Bonnie L Bassler	Annu Rev Cell Dev Biol	2005	16212498	No
3071	898	898.0	34.01	34.0	Peritonectomy procedures.	P H Sugarbaker	Ann Surg	1995	7826158	Yes
3072	1796	898.0	40.39	20.2	Protein aggregation and neurodegenerative disease.	Christopher A Ross, Michelle A Poirier	Nat Med	2004	15272267	No
3073	898	898.0	24.98	25.0	Formation and function of the myofibroblast during tissue repair.	Boris Hinz	J Invest Dermatol	2007	17299435	No
3074	897	897.0	23.71	23.7	Amyloid, the presenilins and Alzheimer's disease.	J Hardy	Trends Neurosci	1997	9106355	No
3075	897	897.0	38.95	39.0	Relativistic electronic-structure calculations employing a two-component no-pair formalism with external-field projection operators.	Hess	Phys Rev A Gen Phys	1986	9897114	Yes
3076	2691	897.0	56.84	18.9	Release of chromatin protein HMGB1 by necrotic cells triggers inflammation.	Paola Scaffidi, Tom Misteli, Marco E Bianchi	Nature	2002	12110890	Yes
3077	897	897.0	23.05	23.1	Natural history of chronic hepatitis C.	Leonard B Seeff	Hepatology	2002	12407575	No
3078	897	897.0	0.0	0.0	Aerobic work capacity in men and women with special reference to age.	I ASTRAND	Acta Physiol Scand Suppl	1960	13794892	Yes
3079	897	897.0	0.0	0.0	The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera.	S V BOYDEN	J Exp Med	1951	14803635	Yes
3080	897	897.0	20.27	20.3	Sustainable hydrogen production.	John A Turner	Science	2004	15310892	Yes
3081	897	897.0	23.54	23.5	Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases.	Thomas A Wynn	J Clin Invest	2007	17332879	No
3082	1793	896.5	75.39	37.7	Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation.	A E Czeizel, I Dudás	N Engl J Med	1992	1307234	Yes
3083	1793	896.5	33.1	16.6	An extensive class of small RNAs in Caenorhabditis elegans.	R C Lee, V Ambros	Science	2001	11679672	Yes
3084	896	896.0	0.0	0.0	Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.	J A Miller	Cancer Res	1970	4915745	No
3085	896	896.0	32.53	32.5	Food reward: brain substrates of wanting and liking.	K C Berridge	Neurosci Biobehav Rev	1996	8622814	No
3086	896	896.0	22.65	22.6	ECM and cell surface proteolysis: regulating cellular ecology.	Z Werb	Cell	1997	9390552	No
3087	896	896.0	16.73	16.7	Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.	R A Frye	Biochem Biophys Res Commun	2000	10873683	Yes
3088	896	896.0	17.61	17.6	MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing.	Victor Ambros	Cell	2003	12809598	No
3089	896	896.0	50.19	50.2	A comprehensive review on metabolic syndrome.	Jaspinder Kaur	Cardiol Res Pract	2014	24711954	No
3090	4477	895.4	168.67	33.7	Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure.	Salim Yusuf, Bertram Pitt, Clarence E Davis, William B Hood, Jay N Cohn	N Engl J Med	1991	2057034	Yes
3091	895	895.0	0.0	0.0	Fundamental patterns of knowing in nursing.	B Carper	ANS Adv Nurs Sci	1978	110216	Yes
3092	1790	895.0	0.0	0.0	A protein sequenator.	P Edman, G Begg	Eur J Biochem	1967	6059350	Yes
3093	895	895.0	22.02	22.0	Serine protease mechanism and specificity.	Lizbeth Hedstrom	Chem Rev	2002	12475199	No
3094	1789	894.5	0.0	0.0	Solubilization of membranes by detergents.	A Helenius, K Simons	Biochim Biophys Acta	1975	1091302	No
3095	894	894.0	25.05	25.1	A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.	J Milbrandt	Science	1987	3672127	Yes
3096	894	894.0	23.39	23.4	Signal transduction via the MAP kinases: proceed at your own RSK.	J Blenis	Proc Natl Acad Sci U S A	1993	8392180	No
3097	894	894.0	19.62	19.6	Understanding the odd science of aging.	Thomas B L Kirkwood	Cell	2005	15734677	No
3098	894	894.0	23.3	23.3	Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms.	William C Aird	Circ Res	2007	17272818	No
3099	1788	894.0	107.26	53.6	Parkinson's disease.	Lorraine V Kalia, Anthony E Lang	Lancet	2015	25904081	No
3100	1786	893.0	0.0	0.0	Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes.	E Engvall, P Perlmann	J Immunol	1972	4113792	Yes
3101	1786	893.0	85.78	42.9	Cronbach's alpha.	J M Bland, D G Altman	BMJ	1997	9055718	Yes
3102	893	893.0	22.08	22.1	Molecular mechanisms of myocardial remodeling.	B Swynghedauw	Physiol Rev	1999	9922372	No
3103	893	893.0	20.85	20.9	Lithium batteries and cathode materials.	M Stanley Whittingham	Chem Rev	2004	15669156	Yes
3104	1785	892.5	55.39	27.7	Mechanisms of biofilm resistance to antimicrobial agents.	T F Mah, G A O'Toole	Trends Microbiol	2001	11166241	No
3105	1784	892.0	0.0	0.0	A rating scale for extrapyramidal side effects.	G M Simpson, J W Angus	Acta Psychiatr Scand Suppl	1970	4917967	Yes
3106	1784	892.0	41.0	20.5	InterProScan--an integration platform for the signature-recognition methods in InterPro.	E M Zdobnov, R Apweiler	Bioinformatics	2001	11590104	Yes
3107	892	892.0	22.07	22.1	A likelihood approach to estimating phylogeny from discrete morphological character data.	P O Lewis	Syst Biol	2001	12116640	Yes
3108	892	892.0	21.59	21.6	r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock.	Michael J Sanderson	Bioinformatics	2003	12538260	Yes
3109	892	892.0	0.0	0.0	A cytoarchitectonic atlas of the spinal cord in the cat.	B REXED	J Comp Neurol	1954	13163236	Yes
3110	892	892.0	22.28	22.3	Viruses in the sea.	Curtis A Suttle	Nature	2005	16163346	No
3111	892	892.0	33.61	33.6	Lanthanide luminescence for biomedical analyses and imaging.	Jean-Claude G Bünzli	Chem Rev	2010	20151630	No
3112	892	892.0	50.4	50.4	Mechanisms linking social ties and support to physical and mental health.	Peggy A Thoits	J Health Soc Behav	2011	21673143	No
3113	1783	891.5	0.0	0.0	Functions of lysosomes.	C De Duve, R Wattiaux	Annu Rev Physiol	1966	5322983	No
3114	891	891.0	0.0	0.0	Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis.	M P Blaustein	Am J Physiol	1977	324293	No
3115	1781	890.5	92.91	46.5	Statistical methods in cancer research. Volume I - The analysis of case-control studies.	N E Breslow, N E Day	IARC Sci Publ	1980	7216345	Yes
3116	1781	890.5	0.0	0.0	Brain stem reticular formation and activation of the EEG.	G Moruzzi, H W Magoun	Electroencephalogr Clin Neurophysiol	1949	18421835	Yes
3117	2671	890.3	61.27	20.4	TGF-beta signalling from cell membrane to nucleus through SMAD proteins.	C H Heldin, K Miyazono, P ten Dijke	Nature	1997	9393997	No
3118	890	890.0	25.49	25.5	Neuropathology of Parkinson's disease.	L S Forno	J Neuropathol Exp Neurol	1996	8786384	No
3119	890	890.0	24.11	24.1	Context, ambiguity, and unlearning: sources of relapse after behavioral extinction.	Mark E Bouton	Biol Psychiatry	2002	12437938	No
3120	890	890.0	0.0	0.0	A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma.	D MATTINGLY	J Clin Pathol	1962	14471419	Yes
3121	1780	890.0	49.69	24.8	Adipocytokines: mediators linking adipose tissue, inflammation and immunity.	Herbert Tilg, Alexander R Moschen	Nat Rev Immunol	2006	16998510	No
3122	1779	889.5	0.0	0.0	Chronic catheterization of the spinal subarachnoid space.	T L Yaksh, T A Rudy	Physiol Behav	1976	14677603	Yes
3123	889	889.0	0.0	0.0	Renin-angiotensin system: biochemistry and mechanisms of action.	M J Peach	Physiol Rev	1977	191856	No
3124	889	889.0	0.0	0.0	Transformation of yeast by a replicating hybrid plasmid.	J D Beggs	Nature	1978	357984	Yes
3125	889	889.0	27.61	27.6	Linkage strategies for genetically complex traits. I. Multilocus models.	N Risch	Am J Hum Genet	1990	2301392	Yes
3126	889	889.0	15.46	15.5	SCF and Cullin/Ring H2-based ubiquitin ligases.	R J Deshaies	Annu Rev Cell Dev Biol	1999	10611969	No
3127	889	889.0	17.25	17.2	DNA methylation in cancer: too much, but also too little.	Melanie Ehrlich	Oncogene	2002	12154403	No
3128	2665	888.3	139.6	46.5	Measurement of health status. Ascertaining the minimal clinically important difference.	R Jaeschke, J Singer, G H Guyatt	Control Clin Trials	1989	2691207	Yes
3129	2665	888.3	56.92	19.0	Computer visualization of three-dimensional image data using IMOD.	J R Kremer, D N Mastronarde, J R McIntosh	J Struct Biol	1996	8742726	Yes
3130	888	888.0	35.78	35.8	Selective attention and the organization of visual information.	J Duncan	J Exp Psychol Gen	1984	6240521	Yes
3131	888	888.0	28.4	28.4	Aging, energy, and oxidative stress in neurodegenerative diseases.	M F Beal	Ann Neurol	1995	7668820	No
3132	888	888.0	19.83	19.8	Twilight zone of protein sequence alignments.	B Rost	Protein Eng	1999	10195279	Yes
3133	1776	888.0	86.41	43.2	Methods for the thematic synthesis of qualitative research in systematic reviews.	James Thomas, Angela Harden	BMC Med Res Methodol	2008	18616818	Yes
3134	887	887.0	0.0	0.0	Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units.	C M Venkatachalam	Biopolymers	1968	5685102	Yes
3135	3548	887.0	96.74	24.2	Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter.	L M Guzman, D Belin, M J Carson, J Beckwith	J Bacteriol	1995	7608087	Yes
3136	1774	887.0	38.06	19.0	A survey of telomerase activity in human cancer.	J W Shay, S Bacchetti	Eur J Cancer	1997	9282118	No
3137	3548	887.0	112.69	28.2	Biological identifications through DNA barcodes.	Paul D N Hebert, Alina Cywinska, Shelley L Ball, Jeremy R deWaard	Proc Biol Sci	2003	12614582	Yes
3138	887	887.0	26.1	26.1	A theory of magnitude: common cortical metrics of time, space and quantity.	Vincent Walsh	Trends Cogn Sci	2003	14585444	Yes
3139	887	887.0	17.17	17.2	Dendritic-cell control of pathogen-driven T-cell polarization.	Martien L Kapsenberg	Nat Rev Immunol	2003	14647480	No
3140	887	887.0	0.0	0.0	The cytoarchitectonic organization of the spinal cord in the cat.	B REXED	J Comp Neurol	1952	14946260	Yes
3141	1774	887.0	44.54	22.3	The host defense of Drosophila melanogaster.	Bruno Lemaitre, Jules Hoffmann	Annu Rev Immunol	2007	17201680	No
3142	887	887.0	0.0	0.0	An approximate distribution of estimates of variance components.	F E SATTERTHWAITE	Biometrics	1946	20287815	Yes
3143	886	886.0	32.07	32.1	Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections.	F Hefti	J Neurosci	1986	3746405	Yes
3144	1772	886.0	46.7	23.4	Endometriosis.	Linda C Giudice, Lee C Kao	Lancet	2004	15541453	No
3145	1771	885.5	43.04	21.5	Multiple nuclear factors interact with the immunoglobulin enhancer sequences.	R Sen, D Baltimore	Cell	1986	3091258	Yes
3146	1771	885.5	0.0	0.0	High resolution acrylamide gel electrophoresis of histones.	S Panyim, R Chalkley	Arch Biochem Biophys	1969	5778650	Yes
3147	885	885.0	55.96	56.0	ROC methodology in radiologic imaging.	C E Metz	Invest Radiol	1986	3095258	No
3148	885	885.0	19.45	19.4	[URE3] as an altered URE2 protein: evidence for a prion analog in Saccharomyces cerevisiae.	R B Wickner	Science	1994	7909170	No
3149	1770	885.0	36.87	18.4	Rho GTPases and signaling networks.	L Van Aelst, C D'Souza-Schorey	Genes Dev	1997	9308960	No
3150	885	885.0	21.94	21.9	A cortical-hippocampal system for declarative memory.	H Eichenbaum	Nat Rev Neurosci	2000	11252767	No
3151	885	885.0	0.0	0.0	Nutrition needs of mammalian cells in tissue culture.	H EAGLE	Science	1955	13255879	Yes
3152	885	885.0	21.97	22.0	The neurobiology of consolidations, or, how stable is the engram?	Yadin Dudai	Annu Rev Psychol	2004	14744210	No
3153	885	885.0	27.59	27.6	Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis.	Michael F Holick	Am J Clin Nutr	2004	14985208	No
3154	885	885.0	23.52	23.5	Metagenomics: application of genomics to uncultured microorganisms.	Jo Handelsman	Microbiol Mol Biol Rev	2004	15590779	No
3155	885	885.0	21.98	22.0	Liver regeneration.	George K Michalopoulos	J Cell Physiol	2007	17559071	No
3156	885	885.0	28.84	28.8	Rethinking schizophrenia.	Thomas R Insel	Nature	2010	21068826	No
3157	1769	884.5	74.03	37.0	Social conditions as fundamental causes of disease.	B G Link, J Phelan	J Health Soc Behav	1995	7560851	No
3158	884	884.0	0.0	0.0	Evolution of ageing.	T B Kirkwood	Nature	1977	593350	Yes
3159	884	884.0	34.55	34.5	Cholesterol and the cell membrane.	P L Yeagle	Biochim Biophys Acta	1985	3904832	No
3160	884	884.0	28.62	28.6	Venous thrombosis: a multicausal disease.	F R Rosendaal	Lancet	1999	10209995	No
3161	1768	884.0	39.5	19.8	Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin.	J J Skehel, D C Wiley	Annu Rev Biochem	2000	10966468	No
3162	884	884.0	21.83	21.8	Toward self-organization and complex matter.	Jean-Marie Lehn	Science	2002	11923524	Yes
3163	2652	884.0	67.88	22.6	Obesity induces a phenotypic switch in adipose tissue macrophage polarization.	Carey N Lumeng, Jennifer L Bodzin, Alan R Saltiel	J Clin Invest	2007	17200717	Yes
3164	1767	883.5	44.83	22.4	The Polycomb complex PRC2 and its mark in life.	Raphaël Margueron, Danny Reinberg	Nature	2011	21248841	No
3165	2650	883.3	0.0	0.0	Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation.	D D SABATINI, K BENSCH, R J BARRNETT	J Cell Biol	1963	13975866	Yes
3166	883	883.0	57.46	57.5	New norms of upper limb fat and muscle areas for assessment of nutritional status.	A R Frisancho	Am J Clin Nutr	1981	6975564	Yes
3167	1766	883.0	63.96	32.0	Nitric oxide synthases in mammals.	R G Knowles, S Moncada	Biochem J	1994	7510950	No
3168	883	883.0	29.65	29.6	Microbial heavy-metal resistance.	D H Nies	Appl Microbiol Biotechnol	1999	10422221	No
3169	5298	883.0	158.57	26.4	Ghrelin is a growth-hormone-releasing acylated peptide from stomach.	M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K Kangawa	Nature	1999	10604470	Yes
3170	2649	883.0	93.23	31.1	Validation of the Insomnia Severity Index as an outcome measure for insomnia research.	C H. Bastien, A Vallières, C M. Morin	Sleep Med	2001	11438246	Yes
3171	883	883.0	0.0	0.0	The diagnosis of ischaemic heart pain and intermittent claudication in field surveys.	G A ROSE	Bull World Health Organ	1962	13974778	Yes
3172	883	883.0	24.87	24.9	PHOTOPROTECTION REVISITED: Genetic and Molecular Approaches.	Krishna K. Niyogi	Annu Rev Plant Physiol Plant Mol Biol	1999	15012213	Yes
3173	883	883.0	17.47	17.5	RNA regulons: coordination of post-transcriptional events.	Jack D Keene	Nat Rev Genet	2007	17572691	No
3174	2649	883.0	81.81	27.3	Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation.	Robert G Hart, Lesly A Pearce, Maria I Aguilar	Ann Intern Med	2007	17577005	Yes
3175	883	883.0	21.0	21.0	Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology.	Michael Forgac	Nat Rev Mol Cell Biol	2007	17912264	No
3176	883	883.0	24.81	24.8	N-heterocyclic carbenes: a new concept in organometallic catalysis.	Wolfgang A Herrmann	Angew Chem Int Ed Engl	2002	19750753	Yes
3177	6176	882.3	214.07	30.6	Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.	H P Adams, B H Bendixen, L J Kappelle, J Biller, B B Love, D L Gordon, E E Marsh	Stroke	1993	7678184	Yes
3178	4411	882.2	130.34	26.1	Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.	T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L Coffman	J Immunol	1986	2419430	Yes
3179	882	882.0	31.33	31.3	Cytochrome oxidase: an endogenous metabolic marker for neuronal activity.	M T Wong-Riley	Trends Neurosci	1989	2469224	No
3180	882	882.0	0.0	0.0	Displaced proximal humeral fractures. I. Classification and evaluation.	C S Neer	J Bone Joint Surg Am	1970	5455339	Yes
3181	882	882.0	15.19	15.2	T cell anergy.	Ronald H Schwartz	Annu Rev Immunol	2003	12471050	No
3182	882	882.0	15.81	15.8	Roles of the NKG2D immunoreceptor and its ligands.	David H Raulet	Nat Rev Immunol	2003	14523385	No
3183	882	882.0	0.0	0.0	The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application.	S HESTRIN	J Biol Chem	1949	18133390	Yes
3184	1763	881.5	57.02	28.5	The capacity of visual working memory for features and conjunctions.	S J Luck, E K Vogel	Nature	1997	9384378	Yes
3185	1763	881.5	0.0	0.0	Immunoassay of insulin with insulin-antibody precipitate.	C N HALES, P J RANDLE	Biochem J	1963	13952078	Yes
3186	1763	881.5	52.4	26.2	Localized surface plasmon resonance spectroscopy and sensing.	Katherine A Willets, Richard P Van Duyne	Annu Rev Phys Chem	2007	17067281	No
3187	7050	881.2	588.62	73.6	Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement.	David Moher, Larissa Shamseer, Mike Clarke, Davina Ghersi, Alessandro Liberati, Mark Petticrew, Paul Shekelle, Lesley A Stewart	Syst Rev	2015	25554246	Yes
3188	881	881.0	31.87	31.9	Fibronectin and its receptors.	E Ruoslahti	Annu Rev Biochem	1988	2972252	No
3189	881	881.0	25.04	25.0	Cells in stress: transcriptional activation of heat shock genes.	R I Morimoto	Science	1993	8451637	No
3190	881	881.0	32.76	32.8	Low-molecular-weight heparins.	J I Weitz	N Engl J Med	1997	9278467	No
3191	1762	881.0	41.78	20.9	Cell locomotion and focal adhesions are regulated by substrate flexibility.	R J Pelham, Y l Wang	Proc Natl Acad Sci U S A	1997	9391082	Yes
3192	1762	881.0	0.0	0.0	A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines.	A H ANTON, D F SAYRE	J Pharmacol Exp Ther	1962	14013351	Yes
3193	881	881.0	26.75	26.8	Neuronal gamma-band synchronization as a fundamental process in cortical computation.	Pascal Fries	Annu Rev Neurosci	2009	19400723	No
3194	2642	880.7	78.04	26.0	Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints.	M K Parmar, V Torri, L Stewart	Stat Med	1998	9921604	Yes
3195	1761	880.5	38.05	19.0	Phosphoinositides in cell regulation and membrane dynamics.	Gilbert Di Paolo, Pietro De Camilli	Nature	2006	17035995	No
3196	1761	880.5	56.21	28.1	Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia.	Amit Etkin, Tor D Wager	Am J Psychiatry	2007	17898336	Yes
3197	3521	880.2	152.52	38.1	FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data.	Robert Oostenveld, Pascal Fries, Eric Maris, Jan-Mathijs Schoffelen	Comput Intell Neurosci	2011	21253357	Yes
3198	880	880.0	34.29	34.3	Strategies of antioxidant defense.	H Sies	Eur J Biochem	1993	7688300	No
3199	1760	880.0	74.54	37.3	Efficacy of the Theory of Planned Behaviour: a meta-analytic review.	C J Armitage, M Conner	Br J Soc Psychol	2001	11795063	Yes
3200	1760	880.0	0.0	0.0	Construct validity in psychological tests.	L J CRONBACH, P E MEEHL	Psychol Bull	1955	13245896	Yes
3201	880	880.0	24.53	24.5	Dengue.	Scott B Halstead	Lancet	2007	17993365	No
3202	5276	879.3	154.79	25.8	Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients.	S Yusuf, P Sleight, J Pogue, J Bosch, R Davies, G Dagenais	N Engl J Med	2000	10639539	Yes
3203	879	879.0	0.0	0.0	Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method.	K Satoh	Clin Chim Acta	1978	719890	Yes
3204	879	879.0	33.54	33.5	The World Health Report 2006: working together for health.	J-J Guilbert	Educ Health (Abingdon)	2006	17178522	Yes
3205	1757	878.5	49.87	24.9	Mesenchymal stem cells as trophic mediators.	Arnold I Caplan, James E Dennis	J Cell Biochem	2006	16619257	No
3206	1757	878.5	57.43	28.7	The spread of obesity in a large social network over 32 years.	Nicholas A Christakis, James H Fowler	N Engl J Med	2007	17652652	Yes
3207	878	878.0	0.0	0.0	Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.	J R David	Proc Natl Acad Sci U S A	1966	5229858	Yes
3208	878	878.0	52.9	52.9	Coping theory and research: past, present, and future.	R S Lazarus	Psychosom Med	1993	8346332	No
3209	878	878.0	36.38	36.4	Socioeconomic disadvantage and child development.	V C McLoyd	Am Psychol	1998	9491747	No
3210	878	878.0	23.1	23.1	Atherosclerosis is an inflammatory disease.	R Ross	Am Heart J	1999	10539839	No
3211	1755	877.5	80.46	40.2	Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry.	A I Basbaum, H L Fields	Annu Rev Neurosci	1984	6143527	No
3212	1755	877.5	37.08	18.5	AMPA receptor trafficking and synaptic plasticity.	Roberto Malinow, Robert C Malenka	Annu Rev Neurosci	2002	12052905	No
3213	1755	877.5	43.52	21.8	Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis.	Daniel J Hicklin, Lee M Ellis	J Clin Oncol	2005	15585754	No
3214	877	877.0	26.94	26.9	Molecular drive: a cohesive mode of species evolution.	G Dover	Nature	1982	7110332	Yes
3215	1754	877.0	39.32	19.7	IAP family proteins--suppressors of apoptosis.	Q L Deveraux, J C Reed	Genes Dev	1999	9990849	No
3216	877	877.0	27.67	27.7	Invited review: Aging and sarcopenia.	Timothy J Doherty	J Appl Physiol (1985)	2003	12970377	No
3217	877	877.0	26.43	26.4	The complex role of estrogens in inflammation.	Rainer H Straub	Endocr Rev	2007	17640948	No
3218	1753	876.5	106.19	53.1	Making sense of Cronbach's alpha.	Mohsen Tavakol, Reg Dennick	Int J Med Educ	2011	28029643	No
3219	8764	876.4	247.73	24.8	Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.	M Dominici, K Le Blanc, I Mueller, I Slaper-Cortenbach, Fc Marini, Ds Krause, Rj Deans, A Keating, Dj Prockop, Em Horwitz	Cytotherapy	2006	16923606	Yes
3220	3505	876.2	105.97	26.5	Real time quantitative PCR.	C A Heid, J Stevens, K J Livak, P M Williams	Genome Res	1996	8908518	Yes
3221	876	876.0	68.06	68.1	A method of analysing interview transcripts in qualitative research.	P Burnard	Nurse Educ Today	1991	1775125	Yes
3222	876	876.0	19.75	19.8	Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes.	D Hanahan	Nature	1985	2986015	Yes
3223	876	876.0	23.93	23.9	Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults.	Bei-Fan Zhou	Biomed Environ Sci	2002	12046553	Yes
3224	1752	876.0	34.73	17.4	Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method.	R Daniel Gietz, Robin A Woods	Methods Enzymol	2002	12073338	Yes
3225	1751	875.5	61.63	30.8	Multiple significance tests: the Bonferroni method.	J M Bland, D G Altman	BMJ	1995	7833759	Yes
3226	4377	875.4	180.95	36.2	DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates.	O Folmer, M Black, W Hoeh, R Lutz, R Vrijenhoek	Mol Mar Biol Biotechnol	1994	7881515	Yes
3227	875	875.0	24.63	24.6	Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system.	T Ikemura	J Mol Biol	1981	6175758	Yes
3228	875	875.0	19.94	19.9	Cytokine receptor signalling.	J N Ihle	Nature	1995	7566171	No
3229	875	875.0	0.0	0.0	Notes on continuous stochastic phenomena.	P A P MORAN	Biometrika	1950	15420245	Yes
3230	875	875.0	28.41	28.4	Neurophysiological and computational principles of cortical rhythms in cognition.	Xiao-Jing Wang	Physiol Rev	2010	20664082	No
3231	874	874.0	34.25	34.2	Computer programs for calculating total from specified free or free from specified total ionic concentrations in aqueous solutions containing multiple metals and ligands.	A Fabiato	Methods Enzymol	1988	3231093	Yes
3232	874	874.0	43.24	43.2	A spreading-activation theory of retrieval in sentence production.	G S Dell	Psychol Rev	1986	3749399	Yes
3233	874	874.0	0.0	0.0	Evaluation of a mental test score for assessment of mental impairment in the elderly.	H M Hodkinson	Age Ageing	1972	4669880	Yes
3234	874	874.0	46.87	46.9	How is the level of free arachidonic acid controlled in mammalian cells?	R F Irvine	Biochem J	1982	6810878	No
3235	874	874.0	42.98	43.0	Gait changes in older adults: predictors of falls or indicators of fear.	B E Maki	J Am Geriatr Soc	1997	9063277	Yes
3236	874	874.0	25.2	25.2	The potential environmental impact of engineered nanomaterials.	Vicki L Colvin	Nat Biotechnol	2003	14520401	Yes
3237	874	874.0	20.77	20.8	The integration of macromolecular diffraction data.	Andrew G W Leslie	Acta Crystallogr D Biol Crystallogr	2006	16369093	No
3238	2622	874.0	71.09	23.7	Astrocyte-endothelial interactions at the blood-brain barrier.	N Joan Abbott, Lars Rönnbäck, Elisabeth Hansson	Nat Rev Neurosci	2006	16371949	No
3239	1748	874.0	62.98	31.5	Extended-connectivity fingerprints.	David Rogers, Mathew Hahn	J Chem Inf Model	2010	20426451	Yes
3240	874	874.0	57.16	57.2	PLATON SQUEEZE: a tool for the calculation of the disordered solvent contribution to the calculated structure factors.	Anthony L Spek	Acta Crystallogr C Struct Chem	2015	25567569	Yes
3241	1747	873.5	100.27	50.1	The Emerging Hallmarks of Cancer Metabolism.	Natalya N Pavlova, Craig B Thompson	Cell Metab	2016	26771115	No
3242	873	873.0	28.25	28.2	Synchronization of cortical activity and its putative role in information processing and learning.	W Singer	Annu Rev Physiol	1993	8466179	No
3243	1745	872.5	46.87	23.4	Toxoplasmosis.	J G Montoya, O Liesenfeld	Lancet	2004	15194258	No
3244	872	872.0	21.68	21.7	At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells.	M Kozak	J Mol Biol	1987	3681984	Yes
3245	872	872.0	25.84	25.8	Jasmonates: an update on biosynthesis, signal transduction and action in plant stress response, growth and development.	C Wasternack	Ann Bot	2007	17513307	No
3246	872	872.0	27.29	27.3	Principles of c-di-GMP signalling in bacteria.	Regine Hengge	Nat Rev Microbiol	2009	19287449	No
3247	2616	872.0	81.13	27.0	Matrix metalloproteinases: regulators of the tumor microenvironment.	Kai Kessenbrock, Vicki Plaks, Zena Werb	Cell	2010	20371345	No
3248	871	871.0	42.8	42.8	Glutathione peroxidase.	A Wendel	Methods Enzymol	1981	7329310	Yes
3249	1742	871.0	0.0	0.0	Virus interference. I. The interferon.	A ISAACS, J LINDENMANN	Proc R Soc Lond B Biol Sci	1957	13465720	Yes
3250	871	871.0	26.22	26.2	Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex.	Satoshi Ikemoto	Brain Res Rev	2007	17574681	No
3251	871	871.0	37.95	38.0	Function and information content of DNA methylation.	Dirk Schübeler	Nature	2015	25592537	No
3252	2612	870.7	124.86	41.6	Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis.	Christopher K Prier, Danica A Rankic, David W C MacMillan	Chem Rev	2013	23509883	No
3253	1741	870.5	55.09	27.5	Cu-catalyzed azide-alkyne cycloaddition.	Morten Meldal, Christian Wenzel Tornøe	Chem Rev	2008	18698735	No
3254	1741	870.5	79.67	39.8	Severe sepsis and septic shock.	Derek C Angus, Tom van der Poll	N Engl J Med	2013	23984731	No
3255	1740	870.0	0.0	0.0	Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells.	A Fabiato, F Fabiato	J Physiol (Paris)	1979	533865	Yes
3256	870	870.0	0.0	0.0	ELECTRON MICROSCOPE STUDIES ON THE STRUCTURE OF NATURAL AND SYNTHETIC PROTEIN FILAMENTS FROM STRIATED MUSCLE.	H E HUXLEY	J Mol Biol	1963	14064165	Yes
3257	1739	869.5	37.8	18.9	Autophagy in health and disease: a double-edged sword.	Takahiro Shintani, Daniel J Klionsky	Science	2004	15528435	No
3258	1739	869.5	61.05	30.5	Type 2 diabetes as an inflammatory disease.	Marc Y Donath, Steven E Shoelson	Nat Rev Immunol	2011	21233852	No
3259	2608	869.3	114.41	38.1	Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material.	P S Walsh, D A Metzger, R Higuchi	Biotechniques	1991	1867860	Yes
3260	869	869.0	20.97	21.0	Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture.	H E Ruley	Nature	1983	6308473	Yes
3261	869	869.0	25.57	25.6	The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease.	David S Ludwig	JAMA	2002	11988062	No
3262	869	869.0	0.0	0.0	On the psychophysical law.	S S STEVENS	Psychol Rev	1957	13441853	Yes
3263	869	869.0	19.31	19.3	The advantages and disadvantages of being polyploid.	Luca Comai	Nat Rev Genet	2005	16304599	No
3264	1738	869.0	43.33	21.7	Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.	William G Kaelin, Peter J Ratcliffe	Mol Cell	2008	18498744	No
3265	1737	868.5	62.55	31.3	Reactive oxygen species, cellular redox systems, and apoptosis.	Magdalena L Circu, Tak Yee Aw	Free Radic Biol Med	2010	20045723	No
3266	868	868.0	21.35	21.4	Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy.	R H Schwartz	Cell	1992	1335362	No
3267	868	868.0	30.84	30.8	Muscarinic receptors--characterization, coupling and function.	M P Caulfield	Pharmacol Ther	1993	7504306	No
3268	3472	868.0	68.63	17.2	DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.	M Okano, D W Bell, D A Haber, E Li	Cell	1999	10555141	Yes
3269	868	868.0	17.37	17.4	Chemistry. How are alkynes scrambled?	Uwe H F Bunz	Science	2005	15821080	No
3270	867	867.0	24.48	24.5	Nidovirales: a new order comprising Coronaviridae and Arteriviridae.	D Cavanagh	Arch Virol	1997	9349308	Yes
3271	867	867.0	28.22	28.2	The stress response to trauma and surgery.	J P Desborough	Br J Anaesth	2000	10927999	No
3272	867	867.0	26.47	26.5	The emotional dog and its rational tail: a social intuitionist approach to moral judgment.	J Haidt	Psychol Rev	2001	11699120	Yes
3273	1734	867.0	54.38	27.2	Mechanisms of mitophagy.	Richard J Youle, Derek P Narendra	Nat Rev Mol Cell Biol	2011	21179058	No
3274	3467	866.8	129.08	32.3	Epidemiology and causes of preterm birth.	Robert L Goldenberg, Jennifer F Culhane, Jay D Iams, Roberto Romero	Lancet	2008	18177778	No
3275	1733	866.5	62.54	31.3	A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR.	V L Miller, J J Mekalanos	J Bacteriol	1988	2836362	Yes
3276	1733	866.5	39.78	19.9	A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach.	S Whelan, N Goldman	Mol Biol Evol	2001	11319253	Yes
3277	2599	866.3	57.8	19.3	Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.	E Li, T H Bestor, R Jaenisch	Cell	1992	1606615	Yes
3278	3465	866.2	102.89	25.7	A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V.	I Vermes, C Haanen, H Steffens-Nakken, C Reutelingsperger	J Immunol Methods	1995	7622868	Yes
3279	1732	866.0	0.0	0.0	A method of trace iodination of proteins for immunologic studies.	P J McConahey, F J Dixon	Int Arch Allergy Appl Immunol	1966	4160044	Yes
3280	866	866.0	43.39	43.4	Molecular aspects of ligand binding to serum albumin.	U Kragh-Hansen	Pharmacol Rev	1981	7027277	No
3281	866	866.0	23.1	23.1	Tensegrity: the architectural basis of cellular mechanotransduction.	D E Ingber	Annu Rev Physiol	1997	9074778	No
3282	866	866.0	34.78	34.8	Post-hoc probing of significant moderational and mediational effects in studies of pediatric populations.	Grayson N Holmbeck	J Pediatr Psychol	2002	11726683	No
3283	866	866.0	0.0	0.0	Agammaglobulinemia.	O C BRUTON	Pediatrics	1952	14929630	Yes
3284	6059	865.6	188.51	26.9	BLAST+: architecture and applications.	Christiam Camacho, George Coulouris, Vahram Avagyan, Ning Ma, Jason Papadopoulos, Kevin Bealer, Thomas L Madden	BMC Bioinformatics	2009	20003500	Yes
3285	1731	865.5	0.0	0.0	Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms.	R J Britten, D E Kohne	Science	1968	4874239	Yes
3286	865	865.0	64.74	64.7	The stabilizing system of the spine. Part I. Function, dysfunction, adaptation, and enhancement.	M M Panjabi	J Spinal Disord	1992	1490034	Yes
3287	865	865.0	23.2	23.2	Cadherins: a molecular family important in selective cell-cell adhesion.	M Takeichi	Annu Rev Biochem	1990	2197976	No
3288	865	865.0	25.78	25.8	Glutathione and its role in cellular functions.	H Sies	Free Radic Biol Med	1999	10569624	No
3289	865	865.0	32.72	32.7	Properties of osteoconductive biomaterials: calcium phosphates.	Racquel Zapanta LeGeros	Clin Orthop Relat Res	2002	11937868	No
3290	1729	864.5	0.0	0.0	Comparative aspects of the brain growth spurt.	J Dobbing, J Sands	Early Hum Dev	1979	118862	Yes
3291	1729	864.5	0.0	0.0	Calcium-dependent bacteriophage DNA infection.	M Mandel, A Higa	J Mol Biol	1970	4922220	Yes
3292	2593	864.3	77.63	25.9	Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?	Dunyaporn Trachootham, Jerome Alexandre, Peng Huang	Nat Rev Drug Discov	2009	19478820	No
3293	864	864.0	29.69	29.7	The role of rumination in depressive disorders and mixed anxiety/depressive symptoms.	S Nolen-Hoeksema	J Abnorm Psychol	2000	11016119	Yes
3294	864	864.0	23.04	23.0	The emotional brain, fear, and the amygdala.	Joseph LeDoux	Cell Mol Neurobiol	2003	14514027	No
3295	1728	864.0	58.29	29.1	THE MEASUREMENT OF SELECTION ON CORRELATED CHARACTERS.	Russell Lande, Stevan J Arnold	Evolution	1983	28556011	Yes
3296	1727	863.5	35.0	17.5	Transcriptional regulation by the phosphorylation-dependent factor CREB.	B Mayr, M Montminy	Nat Rev Mol Cell Biol	2001	11483993	No
3297	863	863.0	25.32	25.3	Apoptosis in cancer therapy: crossing the threshold.	D E Fisher	Cell	1994	8069905	No
3298	863	863.0	35.1	35.1	Why we need observational studies to evaluate the effectiveness of health care.	N Black	BMJ	1996	8634569	Yes
3299	863	863.0	18.72	18.7	The Sp-family of transcription factors.	G Suske	Gene	1999	10570957	No
3300	2587	862.3	69.7	23.2	Nitric oxide and macrophage function.	J MacMicking, Q W Xie, C Nathan	Annu Rev Immunol	1997	9143691	No
3301	2587	862.3	102.24	34.1	Development and applications of CRISPR-Cas9 for genome engineering.	Patrick D Hsu, Eric S Lander, Feng Zhang	Cell	2014	24906146	No
3302	3449	862.2	88.23	22.1	Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells.	E Schreiber, P Matthias, M M Müller, W Schaffner	Nucleic Acids Res	1989	2771659	Yes
3303	862	862.0	41.63	41.6	Infection by verocytotoxin-producing Escherichia coli.	M A Karmali	Clin Microbiol Rev	1989	2644022	No
3304	862	862.0	24.98	25.0	Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.	G Boden	Diabetes	1997	8971073	No
3305	862	862.0	22.41	22.4	The primate basal ganglia: parallel and integrative networks.	Suzanne N Haber	J Chem Neuroanat	2003	14729134	No
3306	862	862.0	26.88	26.9	What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models.	Michael A Babyak	Psychosom Med	2004	15184705	Yes
3307	862	862.0	28.21	28.2	Micellar nanocarriers: pharmaceutical perspectives.	V P Torchilin	Pharm Res	2007	17109211	No
3308	2586	862.0	78.21	26.1	mTOR: from growth signal integration to cancer, diabetes and ageing.	Roberto Zoncu, Alejo Efeyan, David M Sabatini	Nat Rev Mol Cell Biol	2011	21157483	No
3309	1724	862.0	57.96	29.0	Metabolic reprogramming: a cancer hallmark even warburg did not anticipate.	Patrick S Ward, Craig B Thompson	Cancer Cell	2012	22439925	No
3310	2585	861.7	0.0	0.0	Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs.	C A WINTER, E A RISLEY, G W NUSS	Proc Soc Exp Biol Med	1962	14001233	Yes
3311	1723	861.5	42.13	21.1	Principles of protein-protein interactions.	S Jones, J M Thornton	Proc Natl Acad Sci U S A	1996	8552589	No
3312	4307	861.4	119.16	23.8	Jalview Version 2--a multiple sequence alignment editor and analysis workbench.	Andrew M Waterhouse, James B Procter, David M A Martin, Michèle Clamp, Geoffrey J Barton	Bioinformatics	2009	19151095	Yes
3313	6889	861.1	363.11	45.4	The SILVA ribosomal RNA gene database project: improved data processing and web-based tools.	Christian Quast, Elmar Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, Pablo Yarza, Jörg Peplies, Frank Oliver Glöckner	Nucleic Acids Res	2013	23193283	Yes
3314	1722	861.0	61.15	30.6	Compilation and analysis of Escherichia coli promoter DNA sequences.	D K Hawley, W R McClure	Nucleic Acids Res	1983	6344016	No
3315	861	861.0	36.73	36.7	Methods for dealing with reaction time outliers.	R Ratcliff	Psychol Bull	1993	8272468	Yes
3316	861	861.0	17.63	17.6	Targeting death and decoy receptors of the tumour-necrosis factor superfamily.	Avi Ashkenazi	Nat Rev Cancer	2002	12189384	No
3317	861	861.0	28.28	28.3	Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes.	R Bonnet	Antimicrob Agents Chemother	2004	14693512	No
3318	861	861.0	21.78	21.8	Rafts defined: a report on the Keystone Symposium on Lipid Rafts and Cell Function.	Linda J Pike	J Lipid Res	2006	16645198	No
3319	860	860.0	46.95	47.0	Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface.	E H Beachey	J Infect Dis	1981	7014727	No
3320	860	860.0	23.86	23.9	The orbitofrontal cortex and reward.	E T Rolls	Cereb Cortex	2000	10731223	No
3321	860	860.0	17.79	17.8	Progress in human tumour immunology and immunotherapy.	S A Rosenberg	Nature	2001	11357146	No
3322	860	860.0	30.54	30.5	Lanthanide-based luminescent hybrid materials.	Koen Binnemans	Chem Rev	2009	19650663	Yes
3323	860	860.0	22.82	22.8	Genomewide association studies and assessment of the risk of disease.	Teri A Manolio	N Engl J Med	2010	20647212	No
3324	1719	859.5	48.1	24.1	The amygdala: vigilance and emotion.	M Davis, P J Whalen	Mol Psychiatry	2001	11244481	No
3325	1719	859.5	59.02	29.5	bold: The Barcode of Life Data System (http://www.barcodinglife.org).	Sujeevan Ratnasingham, Paul D N Hebert	Mol Ecol Notes	2007	18784790	Yes
3326	1718	859.0	0.0	0.0	Establishment and characterization of a human histiocytic lymphoma cell line (U-937).	C Sundström, K Nilsson	Int J Cancer	1976	178611	Yes
3327	859	859.0	0.0	0.0	An approach for the treatment of penile carcinoma.	R M Cabanas	Cancer	1977	837331	Yes
3328	859	859.0	39.85	39.9	Gender variations in clinical pain experience.	A M Unruh	Pain	1996	8826503	No
3329	859	859.0	20.46	20.5	Antimicrobial reactive oxygen and nitrogen species: concepts and controversies.	Ferric C Fang	Nat Rev Microbiol	2004	15378046	No
3330	859	859.0	18.82	18.8	Molecular signatures of natural selection.	Rasmus Nielsen	Annu Rev Genet	2005	16285858	No
3331	859	859.0	25.79	25.8	Targeting cancer metabolism: a therapeutic window opens.	Matthew G Vander Heiden	Nat Rev Drug Discov	2011	21878982	No
3332	1717	858.5	49.4	24.7	Anemia of chronic disease.	Guenter Weiss, Lawrence T Goodnough	N Engl J Med	2005	15758012	No
3333	1717	858.5	45.77	22.9	ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis.	Benoît D'Autréaux, Michel B Toledano	Nat Rev Mol Cell Biol	2007	17848967	No
3334	1716	858.0	0.0	0.0	Epidermal growth factor.	G Carpenter, S Cohen	Annu Rev Biochem	1979	382984	No
3335	858	858.0	0.0	0.0	The moulding of senescence by natural selection.	W D Hamilton	J Theor Biol	1966	6015424	Yes
3336	858	858.0	17.15	17.1	Computational systems biology.	Hiroaki Kitano	Nature	2002	12432404	No
3337	858	858.0	29.2	29.2	Cognitive and affective development in adolescence.	Laurence Steinberg	Trends Cogn Sci	2005	15668099	No
3338	858	858.0	32.2	32.2	Social support and health: a review of physiological processes potentially underlying links to disease outcomes.	Bert N Uchino	J Behav Med	2006	16758315	No
3339	1716	858.0	47.18	23.6	Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications.	Felix Krueger, Simon R Andrews	Bioinformatics	2011	21493656	Yes
3340	858	858.0	39.34	39.3	U.S. Department of Agriculture and U.S. Department of Health and Human Services, Dietary Guidelines for Americans, 2010. 7th Edition, Washington, DC: U.S. Government Printing Office, January 2011.	Shelley McGuire	Adv Nutr	2011	22332062	Yes
3341	1714	857.0	76.21	38.1	The Modified Mini-Mental State (3MS) examination.	E L Teng, H C Chui	J Clin Psychiatry	1987	3611032	Yes
3342	857	857.0	0.0	0.0	Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities.	F Fonnum	Biochem J	1969	4982085	Yes
3343	857	857.0	26.47	26.5	Sarcopenia: origins and clinical relevance.	I H Rosenberg	J Nutr	1997	9164280	No
3344	857	857.0	35.9	35.9	Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs.	A T Serajuddin	J Pharm Sci	1999	10514356	No
3345	1714	857.0	29.76	14.9	Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.	Lee Zou, Stephen J Elledge	Science	2003	12791985	Yes
3346	857	857.0	0.0	0.0	A modified procedure for lead staining of thin sections.	G MILLONIG	J Biophys Biochem Cytol	1961	14474176	Yes
3347	1713	856.5	0.0	0.0	The hitch-hiking effect of a favourable gene.	J M Smith, J Haigh	Genet Res	1974	4407212	Yes
3348	1713	856.5	52.48	26.2	The evolution of cooperation.	R Axelrod, W D Hamilton	Science	1981	7466396	Yes
3349	856	856.0	15.76	15.8	Molecular dissection of autophagy: two ubiquitin-like systems.	Y Ohsumi	Nat Rev Mol Cell Biol	2001	11265251	No
3350	2567	855.7	122.43	40.8	Concurrent and predictive validity of a self-reported measure of medication adherence.	D E Morisky, L W Green, D M Levine	Med Care	1986	3945130	Yes
3351	3422	855.5	125.29	31.3	Validation of a combined comorbidity index.	M Charlson, T P Szatrowski, J Peterson, J Gold	J Clin Epidemiol	1994	7722560	Yes
3352	1711	855.5	39.95	20.0	p53: puzzle and paradigm.	L J Ko, C Prives	Genes Dev	1996	8654922	No
3353	1710	855.0	73.21	36.6	A formula to estimate the approximate surface area if height and weight be known. 1916.	D Du Bois, E F Du Bois	Nutrition	1989	2520314	No
3354	855	855.0	0.0	0.0	Human cardiovascular adjustments to exercise and thermal stress.	L B Rowell	Physiol Rev	1974	4587247	No
3355	855	855.0	0.0	0.0	Mechanisms of lipid peroxide formation in animal tissues.	E D Wills	Biochem J	1966	5964963	Yes
3356	2565	855.0	79.81	26.6	Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).	R S Spielman, R E McGinnis, W J Ewens	Am J Hum Genet	1993	8447318	Yes
3357	1710	855.0	57.83	28.9	Burden of major musculoskeletal conditions.	Anthony D Woolf, Bruce Pfleger	Bull World Health Organ	2003	14710506	No
3358	855	855.0	24.8	24.8	Redefining oxidative stress.	Dean P Jones	Antioxid Redox Signal	2006	16987039	No
3359	855	855.0	35.06	35.1	Globalization of diabetes: the role of diet, lifestyle, and genes.	Frank B Hu	Diabetes Care	2011	21617109	No
3360	855	855.0	31.94	31.9	T follicular helper cell differentiation, function, and roles in disease.	Shane Crotty	Immunity	2014	25367570	No
3361	3419	854.8	98.3	24.6	Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.	J E Walker, M Saraste, M J Runswick, N J Gay	EMBO J	1982	6329717	Yes
3362	1709	854.5	62.06	31.0	Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation.	J M Reul, E R de Kloet	Endocrinology	1985	2998738	Yes
3363	1709	854.5	41.0	20.5	Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer.	P J Roberts, C J Der	Oncogene	2007	17496923	No
3364	854	854.0	48.71	48.7	Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs).	S Safe	Crit Rev Toxicol	1990	2124811	No
3365	854	854.0	27.96	28.0	The global burden of hepatitis C.	Daniel Lavanchy	Liver Int	2009	19207969	No
3366	3415	853.8	81.6	20.4	SWISS-MODEL: An automated protein homology-modeling server.	Torsten Schwede, Jürgen Kopp, Nicolas Guex, Manuel C Peitsch	Nucleic Acids Res	2003	12824332	Yes
3367	1707	853.5	0.0	0.0	Further improvements in the plaque technique for detecting single antibody-forming cells.	A J Cunningham, A Szenberg	Immunology	1968	5653817	Yes
3368	853	853.0	31.98	32.0	Signaling through phosphatidylcholine breakdown.	J H Exton	J Biol Chem	1990	2104616	No
3369	853	853.0	34.77	34.8	Protein damage and degradation by oxygen radicals. I. general aspects.	K J Davies	J Biol Chem	1987	3036875	Yes
3370	853	853.0	0.0	0.0	Tests for emotionality in rats and mice: a review.	J Archer	Anim Behav	1973	4578750	No
3371	853	853.0	18.45	18.4	Validating survivin as a cancer therapeutic target.	Dario C Altieri	Nat Rev Cancer	2003	12509766	No
3372	1706	853.0	50.56	25.3	Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles.	Donald E Owens, Nicholas A Peppas	Int J Pharm	2006	16303268	No
3373	853	853.0	19.98	20.0	Simple model of spiking neurons.	E M Izhikevich	IEEE Trans Neural Netw	2003	18244602	Yes
3374	1704	852.0	74.54	37.3	Excitatory amino acid transmitters.	J C Watkins, R H Evans	Annu Rev Pharmacol Toxicol	1981	6112965	No
3375	852	852.0	16.81	16.8	Ubiquitin signalling in the NF-kappaB pathway.	Zhijian J Chen	Nat Cell Biol	2005	16056267	No
3376	1704	852.0	40.81	20.4	Angiogenesis as a therapeutic target.	Napoleone Ferrara, Robert S Kerbel	Nature	2005	16355214	No
3377	852	852.0	0.0	0.0	Filter-paper partition chromatography of sugars: 1. General description and application to the qualitative analysis of sugars in apple juice, egg white and foetal blood of sheep. with a note by R. G. Westall.	S M Partridge	Biochem J	1948	16748273	Yes
3378	852	852.0	28.02	28.0	Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade.	Thomas M Tzschentke	Addict Biol	2007	17678505	No
3379	1703	851.5	84.7	42.4	Glutathione reductase.	I Carlberg, B Mannervik	Methods Enzymol	1985	3003504	Yes
3380	1703	851.5	42.81	21.4	Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects.	R P Rao, D H Ballard	Nat Neurosci	1999	10195184	Yes
3381	2554	851.3	62.46	20.8	BCL-2 family members and the mitochondria in apoptosis.	A Gross, J M McDonnell, S J Korsmeyer	Genes Dev	1999	10444588	No
3382	851	851.0	22.72	22.7	Biochemistry and genetics of von Willebrand factor.	J E Sadler	Annu Rev Biochem	1998	9759493	No
3383	851	851.0	27.77	27.8	Distracted and confused?: selective attention under load.	Nilli Lavie	Trends Cogn Sci	2005	15668100	No
3384	851	851.0	24.55	24.6	Towards a neural basis of auditory sentence processing.	Angela D Friederici	Trends Cogn Sci	2002	15866191	Yes
3385	851	851.0	30.28	30.3	Models of speciation by sexual selection on polygenic traits.	R Lande	Proc Natl Acad Sci U S A	1981	16593036	Yes
3386	851	851.0	0.0	0.0	The colorimetric determination of phosphorus.	E J King	Biochem J	1932	16744823	Yes
3387	1701	850.5	71.26	35.6	Glutamate and the pathophysiology of hypoxic--ischemic brain damage.	S M Rothman, J W Olney	Ann Neurol	1986	2421636	No
3388	850	850.0	0.0	0.0	Electrophoretic separation of plasma lipoproteins in agarose gel.	R P Noble	J Lipid Res	1968	4176473	Yes
3389	850	850.0	23.24	23.2	Variation in protection by BCG: implications of and for heterologous immunity.	P E Fine	Lancet	1995	7475776	No
3390	850	850.0	24.35	24.4	Lymphokine production by human T cells in disease states.	S Romagnani	Annu Rev Immunol	1994	8011282	No
3391	2550	850.0	53.35	17.8	Genetic instabilities in human cancers.	C Lengauer, K W Kinzler, B Vogelstein	Nature	1998	9872311	No
3392	850	850.0	0.0	0.0	PRELIMINARY TRIAL OF CARISOPRODOL IN MULTIPLE SCLEROSIS.	B ASHWORTH	Practitioner	1964	14143329	Yes
3393	850	850.0	15.81	15.8	Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.	Lynne E Maquat	Nat Rev Mol Cell Biol	2004	15040442	No
3394	850	850.0	17.48	17.5	Tetraspanin functions and associated microdomains.	Martin E Hemler	Nat Rev Mol Cell Biol	2005	16314869	No
3395	850	850.0	21.82	21.8	Structure and signalling in the IL-17 receptor family.	Sarah L Gaffen	Nat Rev Immunol	2009	19575028	No
3396	1698	849.0	74.81	37.4	Understanding face recognition.	V Bruce, A Young	Br J Psychol	1986	3756376	Yes
3397	849	849.0	18.91	18.9	Folding proteins in fatal ways.	Dennis J Selkoe	Nature	2003	14685251	No
3398	849	849.0	24.26	24.3	Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate.	Randy L Buckner	Neuron	2004	15450170	No
3399	849	849.0	25.77	25.8	Physiology and immunology of the cholinergic antiinflammatory pathway.	Kevin J Tracey	J Clin Invest	2007	17273548	No
3400	1696	848.0	47.18	23.6	Cellular uptake of the tat protein from human immunodeficiency virus.	A D Frankel, C O Pabo	Cell	1988	2849510	Yes
3401	848	848.0	18.95	18.9	The muscular dystrophies.	Alan E H Emery	Lancet	2002	11879882	No
3402	848	848.0	21.22	21.2	Angiogenesis.	Judah Folkman	Annu Rev Med	2006	16409133	No
3403	1695	847.5	0.0	0.0	Hearing lips and seeing voices.	H McGurk, J MacDonald	Nature	1976	1012311	Yes
3404	847	847.0	40.73	40.7	Omega-3 fatty acids in health and disease and in growth and development.	A P Simopoulos	Am J Clin Nutr	1991	1908631	No
3405	847	847.0	24.11	24.1	Anti-inflammatory actions of glucocorticoids: molecular mechanisms.	P J Barnes	Clin Sci (Lond)	1998	9854452	No

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