Unicorn Papers
Top ‱ cited papers from PUBMED
Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authorsCurrently, the list contains 3287 papers with ECcit ≥ 782.0
‱ - permyriad,
, literally meaning "for (every) myriad (ten thousand)"
Volume 1, September 2020
| No. | Citations | ECcit | RCR | ECRCR | Title | Authors | Journal | Year | PMID | Article(?) |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 159932 | 159932.0 | 0.0 | 0.0 | Cleavage of structural proteins during the assembly of the head of bacteriophage T4. | U K Laemmli | Nature | 1970 | 5432063 | Yes |
| 2 | 129141 | 129141.0 | 0.0 | 0.0 | A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. | M M Bradford | Anal. Biochem. | 1976 | 942051 | Yes |
| 3 | 190774 | 47693.5 | 0.0 | 0.0 | Protein measurement with the Folin phenol reagent. | O H LOWRY, N J ROSEBROUGH, A L FARR, R J RANDALL | J. Biol. Chem. | 1951 | 14907713 | Yes |
| 4 | 38676 | 38676.0 | 1546.39 | 1546.4 | A short history of SHELX. | George M Sheldrick | Acta Crystallogr., A, Found. Crystallogr. | 2008 | 18156677 | Yes |
| 5 | 73121 | 36560.5 | 2096.5 | 1048.2 | Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. | K J Livak, T D Schmittgen | Methods | 2001 | 11846609 | Yes |
| 6 | 24924 | 24924.0 | 1042.65 | 1042.7 | Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. | T Mosmann | J. Immunol. Methods | 1983 | 6606682 | Yes |
| 7 | 22896 | 22896.0 | 0.0 | 0.0 | Detection of specific sequences among DNA fragments separated by gel electrophoresis. | E M Southern | J. Mol. Biol. | 1975 | 1195397 | Yes |
| 8 | 45159 | 22579.5 | 1853.24 | 926.6 | Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. | P Chomczynski, N Sacchi | Anal. Biochem. | 1987 | 2440339 | Yes |
| 9 | 20494 | 20494.0 | 0.0 | 0.0 | The assessment and analysis of handedness: the Edinburgh inventory. | R C Oldfield | Neuropsychologia | 1971 | 5146491 | Yes |
| 10 | 20355 | 20355.0 | 506.03 | 506.0 | MicroRNAs: genomics, biogenesis, mechanism, and function. | David P Bartel | Cell | 2004 | 14744438 | No |
| 11 | 17696 | 17696.0 | 463.68 | 463.7 | A new mathematical model for relative quantification in real-time RT-PCR. | M W Pfaffl | Nucleic Acids Res. | 2001 | 11328886 | Yes |
| 12 | 17396 | 17396.0 | 471.24 | 471.2 | MUSCLE: multiple sequence alignment with high accuracy and high throughput. | Robert C Edgar | Nucleic Acids Res. | 2004 | 15034147 | Yes |
| 13 | 16591 | 16591.0 | 0.0 | 0.0 | A rating scale for depression. | M HAMILTON | J. Neurol. Neurosurg. Psychiatry | 1960 | 14399272 | Yes |
| 14 | 45901 | 15300.3 | 0.0 | 0.0 | "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. | M F Folstein, S E Folstein, P R McHugh | J Psychiatr Res | 1975 | 1202204 | Yes |
| 15 | 30084 | 15042.0 | 1132.15 | 566.1 | The neighbor-joining method: a new method for reconstructing phylogenetic trees. | N Saitou, M Nei | Mol. Biol. Evol. | 1987 | 3447015 | Yes |
| 16 | 44632 | 14877.3 | 0.0 | 0.0 | DNA sequencing with chain-terminating inhibitors. | F Sanger, S Nicklen, A R Coulson | Proc. Natl. Acad. Sci. U.S.A. | 1977 | 271968 | Yes |
| 17 | 13875 | 13875.0 | 0.0 | 0.0 | The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. | E S REYNOLDS | J. Cell Biol. | 1963 | 13986422 | Yes |
| 18 | 26787 | 13393.5 | 1629.9 | 815.0 | Statistical methods for assessing agreement between two methods of clinical measurement. | J M Bland, D G Altman | Lancet | 1986 | 2868172 | Yes |
| 19 | 13235 | 13235.0 | 405.1 | 405.1 | Atherosclerosis--an inflammatory disease. | R Ross | N. Engl. J. Med. | 1999 | 9887164 | No |
| 20 | 12483 | 12483.0 | 558.66 | 558.7 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. | M Kimura | J. Mol. Evol. | 1980 | 7463489 | Yes |
| 21 | 12455 | 12455.0 | 0.0 | 0.0 | Tissue sulfhydryl groups. | G L ELLMAN | Arch. Biochem. Biophys. | 1959 | 13650640 | Yes |
| 22 | 36844 | 12281.3 | 1258.16 | 419.4 | CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. | J D Thompson, D G Higgins, T J Gibson | Nucleic Acids Res. | 1994 | 7984417 | Yes |
| 23 | 24559 | 12279.5 | 0.0 | 0.0 | The measurement of observer agreement for categorical data. | J R Landis, G G Koch | Biometrics | 1977 | 843571 | Yes |
| 24 | 24272 | 12136.0 | 1006.78 | 503.4 | Hallmarks of cancer: the next generation. | Douglas Hanahan, Robert A Weinberg | Cell | 2011 | 21376230 | No |
| 25 | 12023 | 12023.0 | 536.74 | 536.7 | Density-functional exchange-energy approximation with correct asymptotic behavior. | Becke | Phys Rev A Gen Phys | 1988 | 9900728 | Yes |
| 26 | 34937 | 11645.7 | 0.0 | 0.0 | Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. | H Towbin, T Staehelin, J Gordon | Proc. Natl. Acad. Sci. U.S.A. | 1979 | 388439 | Yes |
| 27 | 11614 | 11614.0 | 442.4 | 442.4 | CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP. | Joseph Felsenstein | Evolution | 1985 | 28561359 | Yes |
| 28 | 11592 | 11592.0 | 0.0 | 0.0 | High resolution two-dimensional electrophoresis of proteins. | P H O'Farrell | J. Biol. Chem. | 1975 | 236308 | Yes |
| 29 | 10986 | 10986.0 | 332.77 | 332.8 | MicroRNAs: target recognition and regulatory functions. | David P Bartel | Cell | 2009 | 19167326 | No |
| 30 | 21361 | 10680.5 | 0.0 | 0.0 | A rapid method of total lipid extraction and purification. | E G BLIGH, W J DYER | Can J Biochem Physiol | 1959 | 13671378 | Yes |
| 31 | 10369 | 10369.0 | 552.05 | 552.0 | A power primer. | J Cohen | Psychol Bull | 1992 | 19565683 | Yes |
| 32 | 10216 | 10216.0 | 0.0 | 0.0 | DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS. | B J DAVIS | Ann. N. Y. Acad. Sci. | 1964 | 14240539 | Yes |
| 33 | 20313 | 10156.5 | 936.93 | 468.5 | Meta-analysis in clinical trials. | R DerSimonian, N Laird | Control Clin Trials | 1986 | 3802833 | Yes |
| 34 | 19551 | 9775.5 | 1012.57 | 506.3 | The hospital anxiety and depression scale. | A S Zigmond, R P Snaith | Acta Psychiatr Scand | 1983 | 6880820 | Yes |
| 35 | 9706 | 9706.0 | 0.0 | 0.0 | A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. | K BURTON | Biochem. J. | 1956 | 13293190 | Yes |
| 36 | 28903 | 9634.3 | 0.0 | 0.0 | A simple method for the isolation and purification of total lipides from animal tissues. | J FOLCH, M LEES, G H SLOANE STANLEY | J. Biol. Chem. | 1957 | 13428781 | Yes |
| 37 | 9303 | 9303.0 | 307.15 | 307.1 | Projector augmented-wave method. | Blöchl | Phys. Rev., B Condens. Matter | 1994 | 9976227 | Yes |
| 38 | 18456 | 9228.0 | 1019.17 | 509.6 | The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. | J E Ware, C D Sherbourne | Med Care | 1992 | 1593914 | Yes |
| 39 | 9223 | 9223.0 | 445.99 | 446.0 | Structure validation in chemical crystallography. | Anthony L Spek | Acta Crystallogr. D Biol. Crystallogr. | 2009 | 19171970 | Yes |
| 40 | 18107 | 9053.5 | 440.82 | 220.4 | Coot: model-building tools for molecular graphics. | Paul Emsley, Kevin Cowtan | Acta Crystallogr. D Biol. Crystallogr. | 2004 | 15572765 | Yes |
| 41 | 42972 | 8594.4 | 1465.14 | 293.0 | Basic local alignment search tool. | S F Altschul, W Gish, W Miller, E W Myers, D J Lipman | J. Mol. Biol. | 1990 | 2231712 | Yes |
| 42 | 8591 | 8591.0 | 428.58 | 428.6 | Catalase in vitro. | H Aebi | Meth. Enzymol. | 1984 | 6727660 | Yes |
| 43 | 8510 | 8510.0 | 0.0 | 0.0 | The genetics of Caenorhabditis elegans. | S Brenner | Genetics | 1974 | 4366476 | Yes |
| 44 | 8371 | 8371.0 | 0.0 | 0.0 | Phosphorus assay in column chromatography. | G R BARTLETT | J. Biol. Chem. | 1959 | 13641241 | Yes |
| 45 | 24178 | 8059.3 | 863.31 | 287.8 | Generalized Gradient Approximation Made Simple. | Perdew, Burke, Ernzerhof | Phys. Rev. Lett. | 1996 | 10062328 | Yes |
| 46 | 7959 | 7959.0 | 274.57 | 274.6 | The Psychophysics Toolbox. | D H Brainard | Spat Vis | 1997 | 9176952 | Yes |
| 47 | 15716 | 7858.0 | 475.18 | 237.6 | Fast and accurate short read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2009 | 19451168 | Yes |
| 48 | 15498 | 7749.0 | 580.81 | 290.4 | A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. | A P Feinberg, B Vogelstein | Anal. Biochem. | 1983 | 6312838 | Yes |
| 49 | 7643 | 7643.0 | 324.47 | 324.5 | Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). | J F Kurtzke | Neurology | 1983 | 6685237 | Yes |
| 50 | 15158 | 7579.0 | 373.89 | 186.9 | [20] Processing of X-ray diffraction data collected in oscillation mode. | Zbyszek Otwinowski, Wladek Minor | Meth. Enzymol. | 1997 | 27799103 | Yes |
| 51 | 7508 | 7508.0 | 248.55 | 248.6 | XDS. | Wolfgang Kabsch | Acta Crystallogr. D Biol. Crystallogr. | 2010 | 20124692 | Yes |
| 52 | 7500 | 7500.0 | 264.31 | 264.3 | Studies on transformation of Escherichia coli with plasmids. | D Hanahan | J. Mol. Biol. | 1983 | 6345791 | Yes |
| 53 | 7439 | 7439.0 | 179.32 | 179.3 | Mfold web server for nucleic acid folding and hybridization prediction. | Michael Zuker | Nucleic Acids Res. | 2003 | 12824337 | Yes |
| 54 | 7403 | 7403.0 | 170.01 | 170.0 | Linear models and empirical bayes methods for assessing differential expression in microarray experiments. | Gordon K Smyth | Stat Appl Genet Mol Biol | 2004 | 16646809 | Yes |
| 55 | 7385 | 7385.0 | 308.28 | 308.3 | Search and clustering orders of magnitude faster than BLAST. | Robert C Edgar | Bioinformatics | 2010 | 20709691 | Yes |
| 56 | 7331 | 7331.0 | 0.0 | 0.0 | Self-efficacy: toward a unifying theory of behavioral change. | A Bandura | Psychol Rev | 1977 | 847061 | Yes |
| 57 | 21862 | 7287.3 | 1001.12 | 333.7 | Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. | Lee, Yang, Parr | Phys. Rev., B Condens. Matter | 1988 | 9944570 | Yes |
| 58 | 14485 | 7242.5 | 796.02 | 398.0 | The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. | R M Baron, D A Kenny | J Pers Soc Psychol | 1986 | 3806354 | Yes |
| 59 | 7214 | 7214.0 | 218.56 | 218.6 | RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. | Alexandros Stamatakis | Bioinformatics | 2006 | 16928733 | Yes |
| 60 | 7082 | 7082.0 | 245.96 | 246.0 | Evolutionary trees from DNA sequences: a maximum likelihood approach. | J Felsenstein | J. Mol. Evol. | 1981 | 7288891 | Yes |
| 61 | 7072 | 7072.0 | 473.07 | 473.1 | RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. | Alexandros Stamatakis | Bioinformatics | 2014 | 24451623 | Yes |
| 62 | 14129 | 7064.5 | 344.28 | 172.1 | The hallmarks of cancer. | D Hanahan, R A Weinberg | Cell | 2000 | 10647931 | No |
| 63 | 7040 | 7040.0 | 261.83 | 261.8 | The pathogenesis of atherosclerosis: a perspective for the 1990s. | R Ross | Nature | 1993 | 8479518 | No |
| 64 | 7032 | 7032.0 | 340.01 | 340.0 | A new method for measuring daytime sleepiness: the Epworth sleepiness scale. | M W Johns | Sleep | 1991 | 1798888 | Yes |
| 65 | 13987 | 6993.5 | 489.95 | 245.0 | A simple method for displaying the hydropathic character of a protein. | J Kyte, R F Doolittle | J. Mol. Biol. | 1982 | 7108955 | Yes |
| 66 | 6746 | 6746.0 | 0.0 | 0.0 | Improvements in epoxy resin embedding methods. | J H LUFT | J Biophys Biochem Cytol | 1961 | 13764136 | Yes |
| 67 | 6669 | 6669.0 | 245.04 | 245.0 | Vitamin D deficiency. | Michael F Holick | N. Engl. J. Med. | 2007 | 17634462 | No |
| 68 | 13153 | 6576.5 | 439.8 | 219.9 | Quantifying heterogeneity in a meta-analysis. | Julian P T Higgins, Simon G Thompson | Stat Med | 2002 | 12111919 | Yes |
| 69 | 6515 | 6515.0 | 220.73 | 220.7 | Integrins: versatility, modulation, and signaling in cell adhesion. | R O Hynes | Cell | 1992 | 1555235 | No |
| 70 | 12863 | 6431.5 | 0.0 | 0.0 | The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. | K Weber, M Osborn | J. Biol. Chem. | 1969 | 5806584 | Yes |
| 71 | 12840 | 6420.0 | 545.44 | 272.7 | Fast gapped-read alignment with Bowtie 2. | Ben Langmead, Steven L Salzberg | Nat. Methods | 2012 | 22388286 | Yes |
| 72 | 6370 | 6370.0 | 150.63 | 150.6 | The functions of animal microRNAs. | Victor Ambros | Nature | 2004 | 15372042 | No |
| 73 | 6341 | 6341.0 | 275.7 | 275.7 | Banting lecture 1988. Role of insulin resistance in human disease. | G M Reaven | Diabetes | 1988 | 3056758 | No |
| 74 | 6286 | 6286.0 | 365.93 | 365.9 | Psychophysical bases of perceived exertion. | G A Borg | Med Sci Sports Exerc | 1982 | 7154893 | Yes |
| 75 | 12405 | 6202.5 | 314.62 | 157.3 | Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. | Kazutoshi Takahashi, Shinya Yamanaka | Cell | 2006 | 16904174 | Yes |
| 76 | 6107 | 6107.0 | 199.96 | 200.0 | TreeView: an application to display phylogenetic trees on personal computers. | R D Page | Comput. Appl. Biosci. | 1996 | 8902363 | Yes |
| 77 | 6100 | 6100.0 | 0.0 | 0.0 | On the origin of cancer cells. | O WARBURG | Science | 1956 | 13298683 | Yes |
| 78 | 12124 | 6062.0 | 343.35 | 171.7 | MrBayes 3: Bayesian phylogenetic inference under mixed models. | Fredrik Ronquist, John P Huelsenbeck | Bioinformatics | 2003 | 12912839 | Yes |
| 79 | 6031 | 6031.0 | 0.0 | 0.0 | COPPER ENZYMES IN ISOLATED CHLOROPLASTS. POLYPHENOLOXIDASE IN BETA VULGARIS. | D I Arnon | Plant Physiol. | 1949 | 16654194 | Yes |
| 80 | 6026 | 6026.0 | 187.34 | 187.3 | Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. | M C Hochberg | Arthritis Rheum. | 1997 | 9324032 | Yes |
| 81 | 42008 | 6001.1 | 1255.48 | 179.4 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. | S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J Lipman | Nucleic Acids Res. | 1997 | 9254694 | No |
| 82 | 11930 | 5965.0 | 381.74 | 190.9 | Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. | Kresse, Furthmüller | Phys. Rev., B Condens. Matter | 1996 | 9984901 | Yes |
| 83 | 5960 | 5960.0 | 182.21 | 182.2 | Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. | F Tajima | Genetics | 1989 | 2513255 | Yes |
| 84 | 23815 | 5953.8 | 853.81 | 213.5 | Measuring inconsistency in meta-analyses. | Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G Altman | BMJ | 2003 | 12958120 | No |
| 85 | 17429 | 5809.7 | 544.33 | 181.4 | Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nat Protoc | 2009 | 19131956 | Yes |
| 86 | 5805 | 5805.0 | 242.46 | 242.5 | Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. | P S Thomas | Proc. Natl. Acad. Sci. U.S.A. | 1980 | 6159641 | Yes |
| 87 | 5752 | 5752.0 | 196.38 | 196.4 | Semiempirical GGA-type density functional constructed with a long-range dispersion correction. | Stefan Grimme | J Comput Chem | 2006 | 16955487 | Yes |
| 88 | 5751 | 5751.0 | 196.96 | 197.0 | AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. | R W Cox | Comput. Biomed. Res. | 1996 | 8812068 | Yes |
| 89 | 17245 | 5748.3 | 505.69 | 168.6 | VMD: visual molecular dynamics. | W Humphrey, A Dalke, K Schulten | J Mol Graph | 1996 | 8744570 | Yes |
| 90 | 5700 | 5700.0 | 562.06 | 562.1 | Crystal structure refinement with SHELXL. | George M Sheldrick | Acta Crystallogr C Struct Chem | 2015 | 25567568 | Yes |
| 91 | 5687 | 5687.0 | 141.13 | 141.1 | Chromatin modifications and their function. | Tony Kouzarides | Cell | 2007 | 17320507 | No |
| 92 | 11339 | 5669.5 | 275.43 | 137.7 | Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. | S J Clough, A F Bent | Plant J. | 1998 | 10069079 | Yes |
| 93 | 22512 | 5628.0 | 1038.82 | 259.7 | A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. | M E Charlson, P Pompei, K L Ales, C R MacKenzie | J Chronic Dis | 1987 | 3558716 | Yes |
| 94 | 5567 | 5567.0 | 222.28 | 222.3 | "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. | W N Burnette | Anal. Biochem. | 1981 | 6266278 | Yes |
| 95 | 5515 | 5515.0 | 156.51 | 156.5 | PAML 4: phylogenetic analysis by maximum likelihood. | Ziheng Yang | Mol. Biol. Evol. | 2007 | 17483113 | Yes |
| 96 | 5491 | 5491.0 | 0.0 | 0.0 | A simplification of the protein assay method of Lowry et al. which is more generally applicable. | G L Peterson | Anal. Biochem. | 1977 | 603028 | Yes |
| 97 | 5406 | 5406.0 | 0.0 | 0.0 | Solvent content of protein crystals. | B W Matthews | J. Mol. Biol. | 1968 | 5700707 | Yes |
| 98 | 10685 | 5342.5 | 413.52 | 206.8 | Sequencing end-labeled DNA with base-specific chemical cleavages. | A M Maxam, W Gilbert | Meth. Enzymol. | 1980 | 6246368 | Yes |
| 99 | 5331 | 5331.0 | 157.16 | 157.2 | Fast robust automated brain extraction. | Stephen M Smith | Hum Brain Mapp | 2002 | 12391568 | No |
| 100 | 21288 | 5322.0 | 833.43 | 208.4 | Bias in meta-analysis detected by a simple, graphical test. | M Egger, G Davey Smith, M Schneider, C Minder | BMJ | 1997 | 9310563 | Yes |
| 101 | 5279 | 5279.0 | 183.56 | 183.6 | The VideoToolbox software for visual psychophysics: transforming numbers into movies. | D G Pelli | Spat Vis | 1997 | 9176953 | Yes |
| 102 | 10458 | 5229.0 | 330.61 | 165.3 | Analyzing real-time PCR data by the comparative C(T) method. | Thomas D Schmittgen, Kenneth J Livak | Nat Protoc | 2008 | 18546601 | Yes |
| 103 | 15685 | 5228.3 | 0.0 | 0.0 | Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. | W T Friedewald, R I Levy, D S Fredrickson | Clin. Chem. | 1972 | 4337382 | Yes |
| 104 | 5194 | 5194.0 | 0.0 | 0.0 | A low-viscosity epoxy resin embedding medium for electron microscopy. | A R Spurr | J. Ultrastruct. Res. | 1969 | 4887011 | Yes |
| 105 | 5163 | 5163.0 | 217.13 | 217.1 | Ethical guidelines for investigations of experimental pain in conscious animals. | M Zimmermann | Pain | 1983 | 6877845 | No |
| 106 | 15263 | 5087.7 | 579.2 | 193.1 | A new generation of Ca2+ indicators with greatly improved fluorescence properties. | G Grynkiewicz, M Poenie, R Y Tsien | J. Biol. Chem. | 1985 | 3838314 | Yes |
| 107 | 5040 | 5040.0 | 0.0 | 0.0 | Evaluation of survival data and two new rank order statistics arising in its consideration. | N Mantel | Cancer Chemother Rep | 1966 | 5910392 | Yes |
| 108 | 4977 | 4977.0 | 308.55 | 308.6 | Comparative fit indexes in structural models. | P M Bentler | Psychol Bull | 1990 | 2320703 | Yes |
| 109 | 4967 | 4967.0 | 204.34 | 204.3 | The role of protein kinase C in cell surface signal transduction and tumour promotion. | Y Nishizuka | Nature | 1984 | 6232463 | No |
| 110 | 4910 | 4910.0 | 165.64 | 165.6 | Canonical dynamics: Equilibrium phase-space distributions. | Hoover | Phys Rev A Gen Phys | 1985 | 9895674 | Yes |
| 111 | 4890 | 4890.0 | 112.16 | 112.2 | Integrins: bidirectional, allosteric signaling machines. | Richard O Hynes | Cell | 2002 | 12297042 | No |
| 112 | 9728 | 4864.0 | 0.0 | 0.0 | A rapid alkaline extraction procedure for screening recombinant plasmid DNA. | H C Birnboim, J Doly | Nucleic Acids Res. | 1979 | 388356 | Yes |
| 113 | 4836 | 4836.0 | 152.42 | 152.4 | Angiogenesis in cancer, vascular, rheumatoid and other disease. | J Folkman | Nat. Med. | 1995 | 7584949 | No |
| 114 | 4814 | 4814.0 | 209.65 | 209.7 | Density-functional approximation for the correlation energy of the inhomogeneous electron gas. | Perdew | Phys. Rev., B Condens. Matter | 1986 | 9938299 | Yes |
| 115 | 4809 | 4809.0 | 125.76 | 125.8 | Inflammation in atherosclerosis. | Peter Libby | Nature | 2002 | 12490960 | No |
| 116 | 4794 | 4794.0 | 0.0 | 0.0 | Tumor angiogenesis: therapeutic implications. | J Folkman | N. Engl. J. Med. | 1971 | 4938153 | No |
| 117 | 4742 | 4742.0 | 118.7 | 118.7 | p53, the cellular gatekeeper for growth and division. | A J Levine | Cell | 1997 | 9039259 | No |
| 118 | 14198 | 4732.7 | 655.59 | 218.5 | NIH Image to ImageJ: 25 years of image analysis. | Caroline A Schneider, Wayne S Rasband, Kevin W Eliceiri | Nat. Methods | 2012 | 22930834 | No |
| 119 | 4726 | 4726.0 | 0.0 | 0.0 | Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. | J R Vane | Nature New Biol. | 1971 | 5284360 | Yes |
| 120 | 4724 | 4724.0 | 188.01 | 188.0 | The blockade of immune checkpoints in cancer immunotherapy. | Drew M Pardoll | Nat. Rev. Cancer | 2012 | 22437870 | No |
| 121 | 4686 | 4686.0 | 133.71 | 133.7 | Inflammation, atherosclerosis, and coronary artery disease. | Göran K Hansson | N. Engl. J. Med. | 2005 | 15843671 | No |
| 122 | 9303 | 4651.5 | 307.86 | 153.9 | MODELTEST: testing the model of DNA substitution. | D Posada, K A Crandall | Bioinformatics | 1998 | 9918953 | Yes |
| 123 | 4650 | 4650.0 | 185.95 | 185.9 | The Clinical Dementia Rating (CDR): current version and scoring rules. | J C Morris | Neurology | 1993 | 8232972 | Yes |
| 124 | 9298 | 4649.0 | 0.0 | 0.0 | Intraclass correlations: uses in assessing rater reliability. | P E Shrout, J L Fleiss | Psychol Bull | 1979 | 18839484 | No |
| 125 | 9232 | 4616.0 | 249.25 | 124.6 | A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. | Stéphane Guindon, Olivier Gascuel | Syst. Biol. | 2003 | 14530136 | Yes |
| 126 | 4613 | 4613.0 | 0.0 | 0.0 | Development of a rating scale for primary depressive illness. | M Hamilton | Br J Soc Clin Psychol | 1967 | 6080235 | Yes |
| 127 | 4606 | 4606.0 | 130.88 | 130.9 | Biochemistry and molecular cell biology of diabetic complications. | M Brownlee | Nature | 2001 | 11742414 | Yes |
| 128 | 9190 | 4595.0 | 258.6 | 129.3 | MRBAYES: Bayesian inference of phylogenetic trees. | J P Huelsenbeck, F Ronquist | Bioinformatics | 2001 | 11524383 | Yes |
| 129 | 9189 | 4594.5 | 236.55 | 118.3 | Dendritic cells and the control of immunity. | J Banchereau, R M Steinman | Nature | 1998 | 9521319 | No |
| 130 | 9106 | 4553.0 | 0.0 | 0.0 | Statistical aspects of the analysis of data from retrospective studies of disease. | N MANTEL, W HAENSZEL | J. Natl. Cancer Inst. | 1959 | 13655060 | Yes |
| 131 | 4544 | 4544.0 | 137.19 | 137.2 | Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. | T A Springer | Cell | 1994 | 7507411 | No |
| 132 | 22694 | 4538.8 | 721.6 | 144.3 | The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. | J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G Higgins | Nucleic Acids Res. | 1997 | 9396791 | Yes |
| 133 | 9026 | 4513.0 | 0.0 | 0.0 | Prediction of creatinine clearance from serum creatinine. | D W Cockcroft, M H Gault | Nephron | 1976 | 1244564 | Yes |
| 134 | 9016 | 4508.0 | 208.87 | 104.4 | KEGG: kyoto encyclopedia of genes and genomes. | M Kanehisa, S Goto | Nucleic Acids Res. | 2000 | 10592173 | Yes |
| 135 | 4486 | 4486.0 | 146.32 | 146.3 | Inositol trisphosphate and calcium signalling. | M J Berridge | Nature | 1993 | 8381210 | No |
| 136 | 4480 | 4480.0 | 92.19 | 92.2 | BLAT--the BLAST-like alignment tool. | W James Kent | Genome Res. | 2002 | 11932250 | Yes |
| 137 | 8923 | 4461.5 | 0.0 | 0.0 | Continuous cultures of fused cells secreting antibody of predefined specificity. | G Köhler, C Milstein | Nature | 1975 | 1172191 | Yes |
| 138 | 4430 | 4430.0 | 159.31 | 159.3 | The steroid and thyroid hormone receptor superfamily. | R M Evans | Science | 1988 | 3283939 | No |
| 139 | 4428 | 4428.0 | 0.0 | 0.0 | The assessment of anxiety states by rating. | M HAMILTON | Br J Med Psychol | 1959 | 13638508 | Yes |
| 140 | 8854 | 4427.0 | 399.39 | 199.7 | The meaning and use of the area under a receiver operating characteristic (ROC) curve. | J A Hanley, B J McNeil | Radiology | 1982 | 7063747 | Yes |
| 141 | 4413 | 4413.0 | 125.83 | 125.8 | Free radicals in the physiological control of cell function. | Wulf Dröge | Physiol. Rev. | 2002 | 11773609 | No |
| 142 | 8763 | 4381.5 | 223.53 | 111.8 | One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. | K A Datsenko, B L Wanner | Proc. Natl. Acad. Sci. U.S.A. | 2000 | 10829079 | Yes |
| 143 | 8759 | 4379.5 | 0.0 | 0.0 | Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. | Y Cheng, W H Prusoff | Biochem. Pharmacol. | 1973 | 4202581 | Yes |
| 144 | 4362 | 4362.0 | 137.76 | 137.8 | Apoptosis: a review of programmed cell death. | Susan Elmore | Toxicol Pathol | 2007 | 17562483 | No |
| 145 | 4356 | 4356.0 | 0.0 | 0.0 | Modification of seizure activity by electrical stimulation. II. Motor seizure. | R J Racine | Electroencephalogr Clin Neurophysiol | 1972 | 4110397 | Yes |
| 146 | 4319 | 4319.0 | 120.17 | 120.2 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel | Proc. Natl. Acad. Sci. U.S.A. | 1985 | 3881765 | Yes |
| 147 | 4301 | 4301.0 | 169.23 | 169.2 | jModelTest: phylogenetic model averaging. | David Posada | Mol. Biol. Evol. | 2008 | 18397919 | Yes |
| 148 | 4286 | 4286.0 | 199.81 | 199.8 | Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. | Andreas Stang | Eur. J. Epidemiol. | 2010 | 20652370 | Yes |
| 149 | 17091 | 4272.8 | 619.2 | 154.8 | MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. | Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir Kumar | Mol. Biol. Evol. | 2007 | 17488738 | Yes |
| 150 | 4246 | 4246.0 | 150.57 | 150.6 | Adhesion receptors of the immune system. | T A Springer | Nature | 1990 | 1974032 | No |
| 151 | 4230 | 4230.0 | 0.0 | 0.0 | The thiobarbituric acid assay of sialic acids. | L WARREN | J. Biol. Chem. | 1959 | 13672998 | Yes |
| 152 | 4226 | 4226.0 | 0.0 | 0.0 | Selective extraction of polyoma DNA from infected mouse cell cultures. | B Hirt | J. Mol. Biol. | 1967 | 4291934 | Yes |
| 153 | 4203 | 4203.0 | 0.0 | 0.0 | Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. | A Böyum | Scand. J. Clin. Lab. Invest. Suppl. | 1968 | 4179068 | Yes |
| 154 | 16767 | 4191.8 | 849.8 | 212.4 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | PLoS Med. | 2009 | 19621072 | No |
| 155 | 8372 | 4186.0 | 215.93 | 108.0 | Primer3 on the WWW for general users and for biologist programmers. | S Rozen, H Skaletsky | Methods Mol. Biol. | 2000 | 10547847 | Yes |
| 156 | 4183 | 4183.0 | 130.93 | 130.9 | Apoptosis in the pathogenesis and treatment of disease. | C B Thompson | Science | 1995 | 7878464 | No |
| 157 | 4178 | 4178.0 | 120.98 | 121.0 | The NF-kappa B and I kappa B proteins: new discoveries and insights. | A S Baldwin | Annu. Rev. Immunol. | 1996 | 8717528 | No |
| 158 | 4171 | 4171.0 | 109.15 | 109.2 | The biochemistry of apoptosis. | M O Hengartner | Nature | 2000 | 11048727 | No |
| 159 | 4130 | 4130.0 | 94.34 | 94.3 | Rho GTPases and the actin cytoskeleton. | A Hall | Science | 1998 | 9438836 | No |
| 160 | 4129 | 4129.0 | 114.52 | 114.5 | Antimicrobial peptides of multicellular organisms. | Michael Zasloff | Nature | 2002 | 11807545 | Yes |
| 161 | 4126 | 4126.0 | 117.9 | 117.9 | Inflammation and metabolic disorders. | Gökhan S Hotamisligil | Nature | 2006 | 17167474 | No |
| 162 | 4125 | 4125.0 | 91.14 | 91.1 | Epithelial-mesenchymal transitions in tumour progression. | Jean Paul Thiery | Nat. Rev. Cancer | 2002 | 12189386 | No |
| 163 | 16422 | 4105.5 | 0.0 | 0.0 | Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. | J M Chirgwin, A E Przybyla, R J MacDonald, W J Rutter | Biochemistry | 1979 | 518835 | Yes |
| 164 | 8184 | 4092.0 | 243.08 | 121.5 | Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. | W Kabsch, C Sander | Biopolymers | 1983 | 6667333 | Yes |
| 165 | 4086 | 4086.0 | 179.77 | 179.8 | The Strengths and Difficulties Questionnaire: a research note. | R Goodman | J Child Psychol Psychiatry | 1997 | 9255702 | Yes |
| 166 | 12253 | 4084.3 | 473.22 | 157.7 | A simple salting out procedure for extracting DNA from human nucleated cells. | S A Miller, D D Dykes, H F Polesky | Nucleic Acids Res. | 1988 | 3344216 | Yes |
| 167 | 4048 | 4048.0 | 103.9 | 103.9 | Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. | J Castresana | Mol. Biol. Evol. | 2000 | 10742046 | Yes |
| 168 | 12117 | 4039.0 | 0.0 | 0.0 | Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. | H Ohkawa, N Ohishi, K Yagi | Anal. Biochem. | 1979 | 36810 | Yes |
| 169 | 4005 | 4005.0 | 0.0 | 0.0 | THE ENVIRONMENT AND DISEASE: ASSOCIATION OR CAUSATION? | A B HILL | Proc. R. Soc. Med. | 1965 | 14283879 | Yes |
| 170 | 3991 | 3991.0 | 0.0 | 0.0 | Aging: a theory based on free radical and radiation chemistry. | D HARMAN | J Gerontol | 1956 | 13332224 | Yes |
| 171 | 3981 | 3981.0 | 115.73 | 115.7 | Emotion circuits in the brain. | J E LeDoux | Annu. Rev. Neurosci. | 2000 | 10845062 | No |
| 172 | 3937 | 3937.0 | 0.0 | 0.0 | Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. | F Tietze | Anal. Biochem. | 1969 | 4388022 | Yes |
| 173 | 11758 | 3919.3 | 439.66 | 146.6 | Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. | C Yanisch-Perron, J Vieira, J Messing | Gene | 1985 | 2985470 | Yes |
| 174 | 7824 | 3912.0 | 0.0 | 0.0 | A series of normal stages in the development of the chick embryo. | V HAMBURGER, H L HAMILTON | J. Morphol. | 1951 | 24539719 | Yes |
| 175 | 7794 | 3897.0 | 217.15 | 108.6 | Comparative protein modelling by satisfaction of spatial restraints. | A Sali, T L Blundell | J. Mol. Biol. | 1993 | 8254673 | Yes |
| 176 | 3893 | 3893.0 | 143.76 | 143.8 | New M13 vectors for cloning. | J Messing | Meth. Enzymol. | 1983 | 6310323 | Yes |
| 177 | 3886 | 3886.0 | 128.97 | 129.0 | G proteins: transducers of receptor-generated signals. | A G Gilman | Annu. Rev. Biochem. | 1987 | 3113327 | No |
| 178 | 3883 | 3883.0 | 145.62 | 145.6 | Developments of a water-maze procedure for studying spatial learning in the rat. | R Morris | J. Neurosci. Methods | 1984 | 6471907 | Yes |
| 179 | 11605 | 3868.3 | 325.44 | 108.5 | Inference of population structure using multilocus genotype data. | J K Pritchard, M Stephens, P Donnelly | Genetics | 2000 | 10835412 | Yes |
| 180 | 3845 | 3845.0 | 0.0 | 0.0 | A SELF-RATING DEPRESSION SCALE. | W W ZUNG | Arch. Gen. Psychiatry | 1965 | 14221692 | Yes |
| 181 | 7680 | 3840.0 | 273.86 | 136.9 | Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. | H Schägger, G von Jagow | Anal. Biochem. | 1987 | 2449095 | Yes |
| 182 | 7575 | 3787.5 | 303.77 | 151.9 | Operating characteristics of a rank correlation test for publication bias. | C B Begg, M Mazumdar | Biometrics | 1994 | 7786990 | Yes |
| 183 | 3768 | 3768.0 | 73.86 | 73.9 | Generalized lacZ expression with the ROSA26 Cre reporter strain. | P Soriano | Nat. Genet. | 1999 | 9916792 | Yes |
| 184 | 3755 | 3755.0 | 181.94 | 181.9 | Orienting of attention. | M I Posner | Q J Exp Psychol | 1980 | 7367577 | Yes |
| 185 | 11249 | 3749.7 | 439.45 | 146.5 | Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. | Daniel Dindo, Nicolas Demartines, Pierre-Alain Clavien | Ann. Surg. | 2004 | 15273542 | Yes |
| 186 | 22442 | 3740.3 | 1129.73 | 188.3 | MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. | Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir Kumar | Mol. Biol. Evol. | 2011 | 21546353 | Yes |
| 187 | 11205 | 3735.0 | 276.57 | 92.2 | Refinement of macromolecular structures by the maximum-likelihood method. | G N Murshudov, A A Vagin, E J Dodson | Acta Crystallogr. D Biol. Crystallogr. | 1997 | 15299926 | Yes |
| 188 | 11171 | 3723.7 | 607.12 | 202.4 | Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. | Michael I Love, Wolfgang Huber, Simon Anders | Genome Biol. | 2014 | 25516281 | Yes |
| 189 | 3718 | 3718.0 | 123.0 | 123.0 | A modified poisson regression approach to prospective studies with binary data. | Guangyong Zou | Am. J. Epidemiol. | 2004 | 15033648 | Yes |
| 190 | 7415 | 3707.5 | 0.0 | 0.0 | A quantitative description of membrane current and its application to conduction and excitation in nerve. | A L HODGKIN, A F HUXLEY | J. Physiol. (Lond.) | 1952 | 12991237 | Yes |
| 191 | 22142 | 3690.3 | 1062.01 | 177.0 | Global cancer statistics. | Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David Forman | CA Cancer J Clin | 2011 | 21296855 | Yes |
| 192 | 7374 | 3687.0 | 242.64 | 121.3 | Neuropathological stageing of Alzheimer-related changes. | H Braak, E Braak | Acta Neuropathol. | 1991 | 1759558 | No |
| 193 | 3686 | 3686.0 | 101.31 | 101.3 | An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. | M Kozak | Nucleic Acids Res. | 1987 | 3313277 | No |
| 194 | 3667 | 3667.0 | 76.14 | 76.1 | DNA methylation patterns and epigenetic memory. | Adrian Bird | Genes Dev. | 2002 | 11782440 | No |
| 195 | 3662 | 3662.0 | 86.44 | 86.4 | Targeting HIF-1 for cancer therapy. | Gregg L Semenza | Nat. Rev. Cancer | 2003 | 13130303 | No |
| 196 | 3654 | 3654.0 | 92.89 | 92.9 | MUSCLE: a multiple sequence alignment method with reduced time and space complexity. | Robert C Edgar | BMC Bioinformatics | 2004 | 15318951 | Yes |
| 197 | 3632 | 3632.0 | 0.0 | 0.0 | Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. | M M Mesulam | J. Histochem. Cytochem. | 1978 | 24068 | Yes |
| 198 | 7259 | 3629.5 | 0.0 | 0.0 | THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE. | T OMURA, R SATO | J. Biol. Chem. | 1964 | 14209971 | Yes |
| 199 | 7236 | 3618.0 | 405.01 | 202.5 | MAFFT multiple sequence alignment software version 7: improvements in performance and usability. | Kazutaka Katoh, Daron M Standley | Mol. Biol. Evol. | 2013 | 23329690 | Yes |
| 200 | 7200 | 3600.0 | 183.35 | 91.7 | The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. | John Hardy, Dennis J Selkoe | Science | 2002 | 12130773 | No |
| 201 | 7198 | 3599.0 | 178.32 | 89.2 | Inflammation and cancer. | Lisa M Coussens, Zena Werb | Nature | 2002 | 12490959 | No |
| 202 | 7195 | 3597.5 | 0.0 | 0.0 | Assessment of older people: self-maintaining and instrumental activities of daily living. | M P Lawton, E M Brody | Gerontologist | 1969 | 5349366 | Yes |
| 203 | 17936 | 3587.2 | 1167.92 | 233.6 | MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. | Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir Kumar | Mol. Biol. Evol. | 2013 | 24132122 | Yes |
| 204 | 3564 | 3564.0 | 0.0 | 0.0 | Preparation of isolated rat liver cells. | P O Seglen | Methods Cell Biol. | 1976 | 177845 | No |
| 205 | 3563 | 3563.0 | 117.47 | 117.5 | The Cambridge Structural Database: a quarter of a million crystal structures and rising. | Frank H Allen | Acta Crystallogr., B | 2002 | 12037359 | Yes |
| 206 | 7117 | 3558.5 | 313.39 | 156.7 | Three approaches to qualitative content analysis. | Hsiu-Fang Hsieh, Sarah E Shannon | Qual Health Res | 2005 | 16204405 | Yes |
| 207 | 10663 | 3554.3 | 383.59 | 127.9 | A comprehensive set of sequence analysis programs for the VAX. | J Devereux, P Haeberli, O Smithies | Nucleic Acids Res. | 1984 | 6546423 | Yes |
| 208 | 10628 | 3542.7 | 640.08 | 213.4 | Trimmomatic: a flexible trimmer for Illumina sequence data. | Anthony M Bolger, Marc Lohse, Bjoern Usadel | Bioinformatics | 2014 | 24695404 | Yes |
| 209 | 3540 | 3540.0 | 120.69 | 120.7 | A fast diffeomorphic image registration algorithm. | John Ashburner | Neuroimage | 2007 | 17761438 | Yes |
| 210 | 3534 | 3534.0 | 90.51 | 90.5 | Prions. | S B Prusiner | Proc. Natl. Acad. Sci. U.S.A. | 1998 | 9811807 | No |
| 211 | 3516 | 3516.0 | 179.23 | 179.2 | Oxygen-derived free radicals in postischemic tissue injury. | J M McCord | N. Engl. J. Med. | 1985 | 2981404 | No |
| 212 | 3508 | 3508.0 | 181.79 | 181.8 | Revisiting the behavioral model and access to medical care: does it matter? | R M Andersen | J Health Soc Behav | 1995 | 7738325 | Yes |
| 213 | 7011 | 3505.5 | 344.79 | 172.4 | The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. | R F Furchgott, J V Zawadzki | Nature | 1980 | 6253831 | Yes |
| 214 | 3490 | 3490.0 | 0.0 | 0.0 | The McGill Pain Questionnaire: major properties and scoring methods. | R Melzack | Pain | 1975 | 1235985 | Yes |
| 215 | 3485 | 3485.0 | 0.0 | 0.0 | Mutation and cancer: statistical study of retinoblastoma. | A G Knudson | Proc. Natl. Acad. Sci. U.S.A. | 1971 | 5279523 | Yes |
| 216 | 10452 | 3484.0 | 484.74 | 161.6 | The positive and negative syndrome scale (PANSS) for schizophrenia. | S R Kay, A Fiszbein, L A Opler | Schizophr Bull | 1987 | 3616518 | Yes |
| 217 | 6945 | 3472.5 | 186.66 | 93.3 | SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. | N Guex, M C Peitsch | Electrophoresis | 1997 | 9504803 | Yes |
| 218 | 6942 | 3471.0 | 234.24 | 117.1 | Improved tools for biological sequence comparison. | W R Pearson, D J Lipman | Proc. Natl. Acad. Sci. U.S.A. | 1988 | 3162770 | Yes |
| 219 | 3471 | 3471.0 | 207.08 | 207.1 | Investigation of the freely available easy-to-use software 'EZR' for medical statistics. | Y Kanda | Bone Marrow Transplant. | 2013 | 23208313 | Yes |
| 220 | 10405 | 3468.3 | 338.17 | 112.7 | edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. | Mark D Robinson, Davis J McCarthy, Gordon K Smyth | Bioinformatics | 2010 | 19910308 | Yes |
| 221 | 6920 | 3460.0 | 226.43 | 113.2 | A synaptic model of memory: long-term potentiation in the hippocampus. | T V Bliss, G L Collingridge | Nature | 1993 | 8421494 | No |
| 222 | 3456 | 3456.0 | 82.51 | 82.5 | Alternative activation of macrophages. | Siamon Gordon | Nat. Rev. Immunol. | 2003 | 12511873 | No |
| 223 | 10347 | 3449.0 | 1220.55 | 406.8 | MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. | Sudhir Kumar, Glen Stecher, Koichiro Tamura | Mol. Biol. Evol. | 2016 | 27004904 | Yes |
| 224 | 6892 | 3446.0 | 0.0 | 0.0 | A new technique for the assay of infectivity of human adenovirus 5 DNA. | F L Graham, A J van der Eb | Virology | 1973 | 4705382 | Yes |
| 225 | 3446 | 3446.0 | 0.0 | 0.0 | Index for rating diagnostic tests. | W J YOUDEN | Cancer | 1950 | 15405679 | Yes |
| 226 | 3443 | 3443.0 | 88.72 | 88.7 | Alzheimer's disease: genes, proteins, and therapy. | D J Selkoe | Physiol. Rev. | 2001 | 11274343 | No |
| 227 | 3434 | 3434.0 | 0.0 | 0.0 | The genetical evolution of social behaviour. I. | W D Hamilton | J. Theor. Biol. | 1964 | 5875341 | Yes |
| 228 | 3426 | 3426.0 | 87.47 | 87.5 | Cancer cell cycles. | C J Sherr | Science | 1996 | 8939849 | No |
| 229 | 6850 | 3425.0 | 0.0 | 0.0 | FUNCTIONAL EVALUATION: THE BARTHEL INDEX. | F I MAHONEY, D W BARTHEL | Md State Med J | 1965 | 14258950 | Yes |
| 230 | 6846 | 3423.0 | 227.63 | 113.8 | The rise of graphene. | A K Geim, K S Novoselov | Nat Mater | 2007 | 17330084 | Yes |
| 231 | 6843 | 3421.5 | 215.01 | 107.5 | Differential expression analysis for sequence count data. | Simon Anders, Wolfgang Huber | Genome Biol. | 2010 | 20979621 | Yes |
| 232 | 3406 | 3406.0 | 94.2 | 94.2 | Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. | M Kozak | Cell | 1986 | 3943125 | Yes |
| 233 | 6805 | 3402.5 | 0.0 | 0.0 | A new depression scale designed to be sensitive to change. | S A Montgomery, M Asberg | Br J Psychiatry | 1979 | 444788 | Yes |
| 234 | 3376 | 3376.0 | 110.2 | 110.2 | Mild cognitive impairment as a diagnostic entity. | R C Petersen | J. Intern. Med. | 2004 | 15324362 | No |
| 235 | 3373 | 3373.0 | 82.96 | 83.0 | PAML: a program package for phylogenetic analysis by maximum likelihood. | Z Yang | Comput. Appl. Biosci. | 1997 | 9367129 | Yes |
| 236 | 10119 | 3373.0 | 381.06 | 127.0 | The PHQ-9: validity of a brief depression severity measure. | K Kroenke, R L Spitzer, J B Williams | J Gen Intern Med | 2001 | 11556941 | Yes |
| 237 | 16863 | 3372.6 | 0.0 | 0.0 | An inventory for measuring depression. | A T BECK, C H WARD, M MENDELSON, J MOCK, J ERBAUGH | Arch. Gen. Psychiatry | 1961 | 13688369 | Yes |
| 238 | 10073 | 3357.7 | 543.81 | 181.3 | Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. | S M Hsu, L Raine, H Fanger | J. Histochem. Cytochem. | 1981 | 6166661 | Yes |
| 239 | 3350 | 3350.0 | 82.3 | 82.3 | Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. | C J Marshall | Cell | 1995 | 7834738 | No |
| 240 | 3345 | 3345.0 | 115.77 | 115.8 | A new method for predicting signal sequence cleavage sites. | G von Heijne | Nucleic Acids Res. | 1986 | 3714490 | Yes |
| 241 | 3342 | 3342.0 | 140.65 | 140.7 | Studies and perspectives of protein kinase C. | Y Nishizuka | Science | 1986 | 3014651 | No |
| 242 | 3336 | 3336.0 | 0.0 | 0.0 | The detection of disease clustering and a generalized regression approach. | N Mantel | Cancer Res. | 1967 | 6018555 | Yes |
| 243 | 9968 | 3322.7 | 470.81 | 156.9 | Nitric oxide: physiology, pathophysiology, and pharmacology. | S Moncada, R M Palmer, E A Higgs | Pharmacol. Rev. | 1991 | 1852778 | No |
| 244 | 6643 | 3321.5 | 152.89 | 76.4 | A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. | R S Sikorski, P Hieter | Genetics | 1989 | 2659436 | Yes |
| 245 | 6615 | 3307.5 | 217.96 | 109.0 | EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. | Arnaud Delorme, Scott Makeig | J. Neurosci. Methods | 2004 | 15102499 | Yes |
| 246 | 3302 | 3302.0 | 72.11 | 72.1 | The phosphoinositide 3-kinase pathway. | Lewis C Cantley | Science | 2002 | 12040186 | No |
| 247 | 6580 | 3290.0 | 148.6 | 74.3 | Processing of X-ray diffraction data collected in oscillation mode. | Z Otwinowski, W Minor | Meth. Enzymol. | 1997 | 27754618 | Yes |
| 248 | 3285 | 3285.0 | 0.0 | 0.0 | Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. | W H Harris | J Bone Joint Surg Am | 1969 | 5783851 | Yes |
| 249 | 3279 | 3279.0 | 77.07 | 77.1 | Wnt/beta-catenin signaling in development and disease. | Hans Clevers | Cell | 2006 | 17081971 | No |
| 250 | 6521 | 3260.5 | 187.31 | 93.7 | BEDTools: a flexible suite of utilities for comparing genomic features. | Aaron R Quinlan, Ira M Hall | Bioinformatics | 2010 | 20110278 | Yes |
| 251 | 3252 | 3252.0 | 0.0 | 0.0 | THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION. | P LAUREN | Acta Pathol Microbiol Scand | 1965 | 14320675 | Yes |
| 252 | 6502 | 3251.0 | 191.99 | 96.0 | A genetic model for colorectal tumorigenesis. | E R Fearon, B Vogelstein | Cell | 1990 | 2188735 | No |
| 253 | 3233 | 3233.0 | 0.0 | 0.0 | Estimation of nuclear population from microtome sections. | M ABERCROMBIE | Anat. Rec. | 1946 | 21015608 | Yes |
| 254 | 6465 | 3232.5 | 0.0 | 0.0 | Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). | J M McCord, I Fridovich | J. Biol. Chem. | 1969 | 5389100 | Yes |
| 255 | 6463 | 3231.5 | 170.26 | 85.1 | Collective dynamics of 'small-world' networks. | D J Watts, S H Strogatz | Nature | 1998 | 9623998 | Yes |
| 256 | 3220 | 3220.0 | 129.49 | 129.5 | Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. | P Matsudaira | J. Biol. Chem. | 1987 | 3611052 | Yes |
| 257 | 3219 | 3219.0 | 0.0 | 0.0 | The clonal evolution of tumor cell populations. | P C Nowell | Science | 1976 | 959840 | Yes |
| 258 | 6436 | 3218.0 | 0.0 | 0.0 | A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. | W M Bonner, R A Laskey | Eur. J. Biochem. | 1974 | 4850204 | Yes |
| 259 | 3215 | 3215.0 | 90.39 | 90.4 | ras oncogenes in human cancer: a review. | J L Bos | Cancer Res. | 1989 | 2547513 | No |
| 260 | 3210 | 3210.0 | 87.47 | 87.5 | Mechanisms of angiogenesis. | W Risau | Nature | 1997 | 9109485 | No |
| 261 | 3186 | 3186.0 | 103.84 | 103.8 | Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. | S Henikoff | Gene | 1984 | 6235151 | Yes |
| 262 | 3173 | 3173.0 | 84.44 | 84.4 | Apoptosis by death factor. | S Nagata | Cell | 1997 | 9039262 | No |
| 263 | 3165 | 3165.0 | 197.08 | 197.1 | UPARSE: highly accurate OTU sequences from microbial amplicon reads. | Robert C Edgar | Nat. Methods | 2013 | 23955772 | Yes |
| 264 | 6314 | 3157.0 | 130.55 | 65.3 | Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. | A H Brand, N Perrimon | Development | 1993 | 8223268 | Yes |
| 265 | 3142 | 3142.0 | 0.0 | 0.0 | THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. | L HAYFLICK | Exp. Cell Res. | 1965 | 14315085 | Yes |
| 266 | 6267 | 3133.5 | 343.39 | 171.7 | Ligand: a versatile computerized approach for characterization of ligand-binding systems. | P J Munson, D Rodbard | Anal. Biochem. | 1980 | 6254391 | Yes |
| 267 | 12529 | 3132.2 | 403.28 | 100.8 | Global cancer statistics, 2002. | D Max Parkin, Freddie Bray, J Ferlay, Paola Pisani | CA Cancer J Clin | 2005 | 15761078 | Yes |
| 268 | 3118 | 3118.0 | 152.72 | 152.7 | The pathogenesis of atherosclerosis--an update. | R Ross | N. Engl. J. Med. | 1986 | 3511384 | No |
| 269 | 3109 | 3109.0 | 223.91 | 223.9 | Prokka: rapid prokaryotic genome annotation. | Torsten Seemann | Bioinformatics | 2014 | 24642063 | Yes |
| 270 | 3108 | 3108.0 | 100.41 | 100.4 | Sequencing technologies - the next generation. | Michael L Metzker | Nat. Rev. Genet. | 2010 | 19997069 | No |
| 271 | 3103 | 3103.0 | 73.95 | 74.0 | The retinoblastoma protein and cell cycle control. | R A Weinberg | Cell | 1995 | 7736585 | No |
| 272 | 3101 | 3101.0 | 122.65 | 122.7 | Glutamate neurotoxicity and diseases of the nervous system. | D W Choi | Neuron | 1988 | 2908446 | No |
| 273 | 3101 | 3101.0 | 94.94 | 94.9 | Staphylococcus aureus infections. | F D Lowy | N. Engl. J. Med. | 1998 | 9709046 | No |
| 274 | 3089 | 3089.0 | 138.85 | 138.8 | Whatever happened to qualitative description? | M Sandelowski | Res Nurs Health | 2000 | 10940958 | No |
| 275 | 3087 | 3087.0 | 0.0 | 0.0 | Evolution in Mendelian Populations. | S Wright | Genetics | 1931 | 17246615 | Yes |
| 276 | 3084 | 3084.0 | 99.72 | 99.7 | Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. | R B D'Agostino | Stat Med | 1998 | 9802183 | Yes |
| 277 | 3072 | 3072.0 | 105.98 | 106.0 | Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. | Y Nishizuka | Science | 1992 | 1411571 | No |
| 278 | 6141 | 3070.5 | 0.0 | 0.0 | Parkinsonism: onset, progression and mortality. | M M Hoehn, M D Yahr | Neurology | 1967 | 6067254 | Yes |
| 279 | 9192 | 3064.0 | 973.14 | 324.4 | Cancer statistics, 2016. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2016 | 26742998 | Yes |
| 280 | 6117 | 3058.5 | 242.19 | 121.1 | DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. | P Librado, J Rozas | Bioinformatics | 2009 | 19346325 | Yes |
| 281 | 18341 | 3056.8 | 754.91 | 125.8 | Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. | D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C Turner | Diabetologia | 1985 | 3899825 | Yes |
| 282 | 3055 | 3055.0 | 143.14 | 143.1 | EuroQol: the current state of play. | R Brooks | Health Policy | 1996 | 10158943 | No |
| 283 | 3048 | 3048.0 | 70.83 | 70.8 | Protein secondary structure prediction based on position-specific scoring matrices. | D T Jones | J. Mol. Biol. | 1999 | 10493868 | Yes |
| 284 | 3045 | 3045.0 | 92.27 | 92.3 | Multiple sequence alignment with hierarchical clustering. | F Corpet | Nucleic Acids Res. | 1988 | 2849754 | Yes |
| 285 | 3042 | 3042.0 | 103.35 | 103.3 | Revisions in the International System for Staging Lung Cancer. | C F Mountain | Chest | 1997 | 9187198 | Yes |
| 286 | 6070 | 3035.0 | 207.45 | 103.7 | BEAST: Bayesian evolutionary analysis by sampling trees. | Alexei J Drummond, Andrew Rambaut | BMC Evol. Biol. | 2007 | 17996036 | Yes |
| 287 | 3032 | 3032.0 | 0.0 | 0.0 | Bone: formation by autoinduction. | M R Urist | Science | 1965 | 5319761 | Yes |
| 288 | 3020 | 3020.0 | 76.86 | 76.9 | Atherosclerosis. | A J Lusis | Nature | 2000 | 11001066 | No |
| 289 | 3016 | 3016.0 | 90.54 | 90.5 | The dendritic cell system and its role in immunogenicity. | R M Steinman | Annu. Rev. Immunol. | 1991 | 1910679 | No |
| 290 | 3013 | 3013.0 | 82.07 | 82.1 | Marrow stromal cells as stem cells for nonhematopoietic tissues. | D J Prockop | Science | 1997 | 9082988 | No |
| 291 | 3000 | 3000.0 | 103.46 | 103.5 | How mitochondria produce reactive oxygen species. | Michael P Murphy | Biochem. J. | 2009 | 19061483 | No |
| 292 | 8988 | 2996.0 | 232.26 | 77.4 | Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. | J D Dignam, R M Lebovitz, R G Roeder | Nucleic Acids Res. | 1983 | 6828386 | Yes |
| 293 | 2994 | 2994.0 | 70.66 | 70.7 | The green fluorescent protein. | R Y Tsien | Annu. Rev. Biochem. | 1998 | 9759496 | No |
| 294 | 2986 | 2986.0 | 73.5 | 73.5 | Tandem repeats finder: a program to analyze DNA sequences. | G Benson | Nucleic Acids Res. | 1999 | 9862982 | Yes |
| 295 | 2979 | 2979.0 | 120.13 | 120.1 | Bacterial evolution. | C R Woese | Microbiol. Rev. | 1987 | 2439888 | No |
| 296 | 2969 | 2969.0 | 0.0 | 0.0 | A rapid banding technique for human chromosomes. | M Seabright | Lancet | 1971 | 4107917 | Yes |
| 297 | 2961 | 2961.0 | 0.0 | 0.0 | The need for a new medical model: a challenge for biomedicine. | G L Engel | Science | 1977 | 847460 | Yes |
| 298 | 5907 | 2953.5 | 0.0 | 0.0 | Assessment of coma and impaired consciousness. A practical scale. | G Teasdale, B Jennett | Lancet | 1974 | 4136544 | Yes |
| 299 | 8860 | 2953.3 | 514.63 | 171.5 | Cancer statistics, 2013. | Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal | CA Cancer J Clin | 2013 | 23335087 | Yes |
| 300 | 2942 | 2942.0 | 74.81 | 74.8 | Scaling and assessment of data quality. | Philip Evans | Acta Crystallogr. D Biol. Crystallogr. | 2006 | 16369096 | No |
| 301 | 2935 | 2935.0 | 0.0 | 0.0 | Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. | C B Laurell | Anal. Biochem. | 1966 | 5959431 | Yes |
| 302 | 2935 | 2935.0 | 80.79 | 80.8 | Nonalcoholic fatty liver disease. | Paul Angulo | N. Engl. J. Med. | 2002 | 11961152 | No |
| 303 | 2934 | 2934.0 | 0.0 | 0.0 | A membrane-filter technique for the detection of complementary DNA. | D T Denhardt | Biochem. Biophys. Res. Commun. | 1966 | 5963888 | Yes |
| 304 | 11730 | 2932.5 | 0.0 | 0.0 | A new and rapid colorimetric determination of acetylcholinesterase activity. | G L ELLMAN, K D COURTNEY, V ANDRES, R M FEATHER-STONE | Biochem. Pharmacol. | 1961 | 13726518 | Yes |
| 305 | 2918 | 2918.0 | 0.0 | 0.0 | METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS. | M RODBELL | J. Biol. Chem. | 1964 | 14169133 | Yes |
| 306 | 2912 | 2912.0 | 69.19 | 69.2 | TGF-beta signal transduction. | J Massagué | Annu. Rev. Biochem. | 1998 | 9759503 | No |
| 307 | 5809 | 2904.5 | 162.58 | 81.3 | tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. | T M Lowe, S R Eddy | Nucleic Acids Res. | 1997 | 9023104 | Yes |
| 308 | 5808 | 2904.0 | 173.89 | 86.9 | Genomic sequencing. | G M Church, W Gilbert | Proc. Natl. Acad. Sci. U.S.A. | 1984 | 6326095 | Yes |
| 309 | 8653 | 2884.3 | 466.88 | 155.6 | Development and validation of brief measures of positive and negative affect: the PANAS scales. | D Watson, L A Clark, A Tellegen | J Pers Soc Psychol | 1988 | 3397865 | Yes |
| 310 | 5762 | 2881.0 | 146.77 | 73.4 | Functional rafts in cell membranes. | K Simons, E Ikonen | Nature | 1997 | 9177342 | No |
| 311 | 5761 | 2880.5 | 168.93 | 84.5 | Mitochondria and apoptosis. | D R Green, J C Reed | Science | 1998 | 9721092 | No |
| 312 | 2878 | 2878.0 | 111.96 | 112.0 | genepop'007: a complete re-implementation of the genepop software for Windows and Linux. | François Rousset | Mol Ecol Resour | 2008 | 21585727 | Yes |
| 313 | 2876 | 2876.0 | 65.28 | 65.3 | Mammalian neural stem cells. | F H Gage | Science | 2000 | 10688783 | No |
| 314 | 2869 | 2869.0 | 75.3 | 75.3 | Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. | Rakesh K Jain | Science | 2005 | 15637262 | No |
| 315 | 2868 | 2868.0 | 72.65 | 72.7 | Protein production by auto-induction in high density shaking cultures. | F William Studier | Protein Expr. Purif. | 2005 | 15915565 | Yes |
| 316 | 8589 | 2863.0 | 0.0 | 0.0 | Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. | W H Habig, M J Pabst, W B Jakoby | J. Biol. Chem. | 1974 | 4436300 | Yes |
| 317 | 2860 | 2860.0 | 68.84 | 68.8 | Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. | G R Martin | Proc. Natl. Acad. Sci. U.S.A. | 1981 | 6950406 | Yes |
| 318 | 2856 | 2856.0 | 104.03 | 104.0 | The molecular heterogeneity of protein kinase C and its implications for cellular regulation. | Y Nishizuka | Nature | 1988 | 3045562 | No |
| 319 | 2855 | 2855.0 | 111.14 | 111.1 | Updating P300: an integrative theory of P3a and P3b. | John Polich | Clin Neurophysiol | 2007 | 17573239 | No |
| 320 | 2848 | 2848.0 | 81.58 | 81.6 | Cancer. p53, guardian of the genome. | D P Lane | Nature | 1992 | 1614522 | No |
| 321 | 2846 | 2846.0 | 0.0 | 0.0 | Transformed up-down methods in psychoacoustics. | H Levitt | J. Acoust. Soc. Am. | 1971 | 5541744 | Yes |
| 322 | 2846 | 2846.0 | 78.02 | 78.0 | Why most published research findings are false. | John P A Ioannidis | PLoS Med. | 2005 | 16060722 | Yes |
| 323 | 2835 | 2835.0 | 0.0 | 0.0 | Determination of protein: a modification of the Lowry method that gives a linear photometric response. | E F Hartree | Anal. Biochem. | 1972 | 4115981 | Yes |
| 324 | 5649 | 2824.5 | 227.19 | 113.6 | AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. | Oleg Trott, Arthur J Olson | J Comput Chem | 2010 | 19499576 | Yes |
| 325 | 2823 | 2823.0 | 65.04 | 65.0 | Hypoxia--a key regulatory factor in tumour growth. | Adrian L Harris | Nat. Rev. Cancer | 2002 | 11902584 | No |
| 326 | 2822 | 2822.0 | 86.19 | 86.2 | Microglia: a sensor for pathological events in the CNS. | G W Kreutzberg | Trends Neurosci. | 1996 | 8843599 | No |
| 327 | 8454 | 2818.0 | 409.53 | 136.5 | A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. | J Ware, M Kosinski, S D Keller | Med Care | 1996 | 8628042 | Yes |
| 328 | 2814 | 2814.0 | 135.94 | 135.9 | A concordance correlation coefficient to evaluate reproducibility. | L I Lin | Biometrics | 1989 | 2720055 | Yes |
| 329 | 2810 | 2810.0 | 61.14 | 61.1 | Signal transduction by the JNK group of MAP kinases. | R J Davis | Cell | 2000 | 11057897 | No |
| 330 | 5617 | 2808.5 | 258.59 | 129.3 | Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. | U H Graneheim, B Lundman | Nurse Educ Today | 2004 | 14769454 | No |
| 331 | 5612 | 2806.0 | 143.65 | 71.8 | MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. | Jürgen Cox, Matthias Mann | Nat. Biotechnol. | 2008 | 19029910 | Yes |
| 332 | 2804 | 2804.0 | 0.0 | 0.0 | A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. | E Pfeiffer | J Am Geriatr Soc | 1975 | 1159263 | Yes |
| 333 | 2803 | 2803.0 | 101.48 | 101.5 | Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. | A H Wyllie | Nature | 1980 | 6245367 | Yes |
| 334 | 2783 | 2783.0 | 63.85 | 63.9 | Profile hidden Markov models. | S R Eddy | Bioinformatics | 1998 | 9918945 | No |
| 335 | 5558 | 2779.0 | 168.21 | 84.1 | Control of goal-directed and stimulus-driven attention in the brain. | Maurizio Corbetta, Gordon L Shulman | Nat. Rev. Neurosci. | 2002 | 11994752 | No |
| 336 | 11085 | 2771.2 | 371.29 | 92.8 | Features and development of Coot. | P Emsley, B Lohkamp, W G Scott, K Cowtan | Acta Crystallogr. D Biol. Crystallogr. | 2010 | 20383002 | Yes |
| 337 | 2771 | 2771.0 | 97.29 | 97.3 | What is the evidence that tumors are angiogenesis dependent? | J Folkman | J. Natl. Cancer Inst. | 1990 | 1688381 | No |
| 338 | 2764 | 2764.0 | 88.12 | 88.1 | The adolescent brain and age-related behavioral manifestations. | L P Spear | Neurosci Biobehav Rev | 2000 | 10817843 | No |
| 339 | 2763 | 2763.0 | 259.87 | 259.9 | SHELXT - integrated space-group and crystal-structure determination. | George M Sheldrick | Acta Crystallogr A Found Adv | 2015 | 25537383 | Yes |
| 340 | 2760 | 2760.0 | 0.0 | 0.0 | Principles that govern the folding of protein chains. | C B Anfinsen | Science | 1973 | 4124164 | Yes |
| 341 | 5517 | 2758.5 | 261.56 | 130.8 | Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. | Kristopher J Preacher, Andrew F Hayes | Behav Res Methods | 2008 | 18697684 | Yes |
| 342 | 2758 | 2758.0 | 78.98 | 79.0 | Caspases: the executioners of apoptosis. | G M Cohen | Biochem. J. | 1997 | 9337844 | No |
| 343 | 2758 | 2758.0 | 0.0 | 0.0 | Amino acid metabolism in mammalian cell cultures. | H EAGLE | Science | 1959 | 13675766 | Yes |
| 344 | 2757 | 2757.0 | 126.86 | 126.9 | Measuring the accuracy of diagnostic systems. | J A Swets | Science | 1988 | 3287615 | No |
| 345 | 5505 | 2752.5 | 109.26 | 54.6 | Translating the histone code. | T Jenuwein, C D Allis | Science | 2001 | 11498575 | No |
| 346 | 5496 | 2748.0 | 182.66 | 91.3 | Velvet: algorithms for de novo short read assembly using de Bruijn graphs. | Daniel R Zerbino, Ewan Birney | Genome Res. | 2008 | 18349386 | Yes |
| 347 | 2745 | 2745.0 | 83.41 | 83.4 | A catalogue of splice junction sequences. | S M Mount | Nucleic Acids Res. | 1982 | 7063411 | Yes |
| 348 | 2745 | 2745.0 | 111.2 | 111.2 | Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. | Russell A Barkley | Psychol Bull | 1997 | 9000892 | No |
| 349 | 8227 | 2742.3 | 427.39 | 142.5 | Cancer statistics, 2012. | Rebecca Siegel, Deepa Naishadham, Ahmedin Jemal | CA Cancer J Clin | 2012 | 22237781 | Yes |
| 350 | 2741 | 2741.0 | 0.0 | 0.0 | Generalized expectancies for internal versus external control of reinforcement. | J B Rotter | Psychol Monogr | 1966 | 5340840 | No |
| 351 | 2738 | 2738.0 | 119.75 | 119.8 | ANALYZING TABLES OF STATISTICAL TESTS. | William R Rice | Evolution | 1989 | 28568501 | Yes |
| 352 | 2734 | 2734.0 | 0.0 | 0.0 | Estimation of average heterozygosity and genetic distance from a small number of individuals. | M Nei | Genetics | 1978 | 17248844 | Yes |
| 353 | 2725 | 2725.0 | 79.84 | 79.8 | Novel proteinaceous infectious particles cause scrapie. | S B Prusiner | Science | 1982 | 6801762 | Yes |
| 354 | 8153 | 2717.7 | 665.37 | 221.8 | Cancer statistics, 2015. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2015 | 25559415 | Yes |
| 355 | 2717 | 2717.0 | 121.09 | 121.1 | Tissue destruction by neutrophils. | S J Weiss | N. Engl. J. Med. | 1989 | 2536474 | No |
| 356 | 5422 | 2711.0 | 121.51 | 60.8 | Statistical significance for genomewide studies. | John D Storey, Robert Tibshirani | Proc. Natl. Acad. Sci. U.S.A. | 2003 | 12883005 | Yes |
| 357 | 2710 | 2710.0 | 69.56 | 69.6 | Instability and decay of the primary structure of DNA. | T Lindahl | Nature | 1993 | 8469282 | No |
| 358 | 2706 | 2706.0 | 74.68 | 74.7 | Glutamate uptake. | N C Danbolt | Prog. Neurobiol. | 2001 | 11369436 | No |
| 359 | 2705 | 2705.0 | 108.41 | 108.4 | How do you feel--now? The anterior insula and human awareness. | A D Bud Craig | Nat. Rev. Neurosci. | 2009 | 19096369 | No |
| 360 | 5393 | 2696.5 | 0.0 | 0.0 | Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. | D E Paglia, W N Valentine | J. Lab. Clin. Med. | 1967 | 6066618 | Yes |
| 361 | 2695 | 2695.0 | 99.07 | 99.1 | Protective and damaging effects of stress mediators. | B S McEwen | N. Engl. J. Med. | 1998 | 9428819 | No |
| 362 | 8080 | 2693.3 | 315.26 | 105.1 | Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. | E R DeLong, D M DeLong, D L Clarke-Pearson | Biometrics | 1988 | 3203132 | Yes |
| 363 | 2689 | 2689.0 | 96.1 | 96.1 | What's wrong with Bonferroni adjustments. | T V Perneger | BMJ | 1998 | 9553006 | No |
| 364 | 5376 | 2688.0 | 0.0 | 0.0 | Radiological assessment of osteo-arthrosis. | J H KELLGREN, J S LAWRENCE | Ann. Rheum. Dis. | 1957 | 13498604 | Yes |
| 365 | 5371 | 2685.5 | 0.0 | 0.0 | Microsomal lipid peroxidation. | J A Buege, S D Aust | Meth. Enzymol. | 1978 | 672633 | Yes |
| 366 | 2685 | 2685.0 | 78.6 | 78.6 | ras genes. | M Barbacid | Annu. Rev. Biochem. | 1987 | 3304147 | No |
| 367 | 2673 | 2673.0 | 0.0 | 0.0 | New methods for calculating metabolic rate with special reference to protein metabolism. | J B DE B WEIR | J. Physiol. (Lond.) | 1949 | 15394301 | Yes |
| 368 | 10686 | 2671.5 | 300.89 | 75.2 | Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. | Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg | Genome Biol. | 2009 | 19261174 | Yes |
| 369 | 8013 | 2671.0 | 0.0 | 0.0 | Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. | J F Kerr, A H Wyllie, A R Currie | Br. J. Cancer | 1972 | 4561027 | No |
| 370 | 2670 | 2670.0 | 130.03 | 130.0 | An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. | Peter C Austin | Multivariate Behav Res | 2011 | 21818162 | Yes |
| 371 | 13349 | 2669.8 | 519.03 | 103.8 | Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. | O P Hamill, A Marty, E Neher, B Sakmann, F J Sigworth | Pflugers Arch. | 1981 | 6270629 | Yes |
| 372 | 2665 | 2665.0 | 0.0 | 0.0 | The Scree Test For The Number Of Factors. | R B Cattell | Multivariate Behav Res | 1966 | 26828106 | Yes |
| 373 | 2664 | 2664.0 | 0.0 | 0.0 | Aggregation of blood platelets by adenosine diphosphate and its reversal. | G V BORN | Nature | 1962 | 13871375 | Yes |
| 374 | 2657 | 2657.0 | 96.33 | 96.3 | Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. | Vanderbilt | Phys. Rev., B Condens. Matter | 1990 | 9993096 | Yes |
| 375 | 2655 | 2655.0 | 0.0 | 0.0 | The determination of enzyme inhibitor constants. | M DIXON | Biochem. J. | 1953 | 13093635 | Yes |
| 376 | 2651 | 2651.0 | 107.47 | 107.5 | Modeling valuations for EuroQol health states. | P Dolan | Med Care | 1997 | 9366889 | Yes |
| 377 | 10590 | 2647.5 | 434.28 | 108.6 | G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. | Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner | Behav Res Methods | 2007 | 17695343 | Yes |
| 378 | 2640 | 2640.0 | 0.0 | 0.0 | Staining of tissue sections for electron microscopy with heavy metals. | M L WATSON | J Biophys Biochem Cytol | 1958 | 13563554 | Yes |
| 379 | 5278 | 2639.0 | 155.76 | 77.9 | An integrative theory of prefrontal cortex function. | E K Miller, J D Cohen | Annu. Rev. Neurosci. | 2001 | 11283309 | No |
| 380 | 7867 | 2622.3 | 177.32 | 59.1 | Significance analysis of microarrays applied to the ionizing radiation response. | V G Tusher, R Tibshirani, G Chu | Proc. Natl. Acad. Sci. U.S.A. | 2001 | 11309499 | Yes |
| 381 | 2619 | 2619.0 | 94.91 | 94.9 | Graphene: status and prospects. | A K Geim | Science | 2009 | 19541989 | Yes |
| 382 | 2613 | 2613.0 | 95.29 | 95.3 | Integrins: a family of cell surface receptors. | R O Hynes | Cell | 1987 | 3028640 | No |
| 383 | 2608 | 2608.0 | 0.0 | 0.0 | Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. | J Cohen | Psychol Bull | 1968 | 19673146 | Yes |
| 384 | 2601 | 2601.0 | 96.54 | 96.5 | Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. | L R Squire | Psychol Rev | 1992 | 1594723 | No |
| 385 | 2598 | 2598.0 | 111.63 | 111.6 | Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. | J H Morrissey | Anal. Biochem. | 1981 | 6172996 | Yes |
| 386 | 2589 | 2589.0 | 92.35 | 92.3 | Biological roles of oligosaccharides: all of the theories are correct. | A Varki | Glycobiology | 1993 | 8490246 | No |
| 387 | 2581 | 2581.0 | 98.98 | 99.0 | Development of a classification system for periodontal diseases and conditions. | G C Armitage | Ann. Periodontol. | 1999 | 10863370 | No |
| 388 | 5151 | 2575.5 | 108.24 | 54.1 | The ubiquitin system. | A Hershko, A Ciechanover | Annu. Rev. Biochem. | 1998 | 9759494 | No |
| 389 | 5149 | 2574.5 | 273.35 | 136.7 | The timed "Up & Go": a test of basic functional mobility for frail elderly persons. | D Podsiadlo, S Richardson | J Am Geriatr Soc | 1991 | 1991946 | Yes |
| 390 | 5149 | 2574.5 | 169.8 | 84.9 | Ab initio molecular dynamics for liquid metals. | Kresse, Hafner | Phys. Rev., B Condens. Matter | 1993 | 10004490 | Yes |
| 391 | 7713 | 2571.0 | 1078.68 | 359.6 | Cancer Statistics, 2017. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2017 | 28055103 | Yes |
| 392 | 2569 | 2569.0 | 70.77 | 70.8 | The scanning model for translation: an update. | M Kozak | J. Cell Biol. | 1989 | 2645293 | No |
| 393 | 2568 | 2568.0 | 75.51 | 75.5 | The basis of anisotropic water diffusion in the nervous system - a technical review. | Christian Beaulieu | NMR Biomed | 2002 | 12489094 | No |
| 394 | 2565 | 2565.0 | 0.0 | 0.0 | [A micro-method of immuno-electrophoresis]. | J J SCHEIDEGGER | Int. Arch. Allergy Appl. Immunol. | 1955 | 13262900 | Yes |
| 395 | 2558 | 2558.0 | 107.74 | 107.7 | Nitric oxide as a secretory product of mammalian cells. | C Nathan | FASEB J. | 1992 | 1381691 | No |
| 396 | 2548 | 2548.0 | 62.97 | 63.0 | Activators and target genes of Rel/NF-kappaB transcription factors. | H L Pahl | Oncogene | 1999 | 10602461 | No |
| 397 | 5089 | 2544.5 | 0.0 | 0.0 | Preparation of iodine-131 labelled human growth hormone of high specific activity. | W M HUNTER, F C GREENWOOD | Nature | 1962 | 14450081 | Yes |
| 398 | 2543 | 2543.0 | 77.85 | 77.8 | The origins and the future of microfluidics. | George M Whitesides | Nature | 2006 | 16871203 | No |
| 399 | 2539 | 2539.0 | 0.0 | 0.0 | Basic principles of ROC analysis. | C E Metz | Semin Nucl Med | 1978 | 112681 | Yes |
| 400 | 2536 | 2536.0 | 75.5 | 75.5 | I-TASSER server for protein 3D structure prediction. | Yang Zhang | BMC Bioinformatics | 2008 | 18215316 | Yes |
| 401 | 7594 | 2531.3 | 179.43 | 59.8 | Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. | Benjamin P Lewis, Christopher B Burge, David P Bartel | Cell | 2005 | 15652477 | Yes |
| 402 | 7593 | 2531.0 | 0.0 | 0.0 | Determination of serum proteins by means of the biuret reaction. | A G GORNALL, C J BARDAWILL, M M DAVID | J. Biol. Chem. | 1949 | 18110453 | Yes |
| 403 | 10119 | 2529.8 | 286.05 | 71.5 | Haploview: analysis and visualization of LD and haplotype maps. | J C Barrett, B Fry, J Maller, M J Daly | Bioinformatics | 2005 | 15297300 | Yes |
| 404 | 2529 | 2529.0 | 0.0 | 0.0 | Observational study of behavior: sampling methods. | J Altmann | Behaviour | 1974 | 4597405 | No |
| 405 | 2529 | 2529.0 | 57.74 | 57.7 | STATs and gene regulation. | J E Darnell | Science | 1997 | 9287210 | No |
| 406 | 2529 | 2529.0 | 53.77 | 53.8 | Cell signaling by receptor tyrosine kinases. | J Schlessinger | Cell | 2000 | 11057895 | No |
| 407 | 7575 | 2525.0 | 387.33 | 129.1 | A global measure of perceived stress. | S Cohen, T Kamarck, R Mermelstein | J Health Soc Behav | 1983 | 6668417 | Yes |
| 408 | 2523 | 2523.0 | 74.67 | 74.7 | Oxidative stress, antioxidants and stress tolerance. | Ron Mittler | Trends Plant Sci. | 2002 | 12234732 | No |
| 409 | 2519 | 2519.0 | 60.02 | 60.0 | Somatic generation of antibody diversity. | S Tonegawa | Nature | 1983 | 6300689 | No |
| 410 | 5020 | 2510.0 | 169.06 | 84.5 | Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. | Florian Weigend, Reinhart Ahlrichs | Phys Chem Chem Phys | 2005 | 16240044 | Yes |
| 411 | 2506 | 2506.0 | 74.92 | 74.9 | Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. | A T Brünger | Nature | 1992 | 18481394 | Yes |
| 412 | 2496 | 2496.0 | 74.17 | 74.2 | Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. | M Kozak | Nucleic Acids Res. | 1984 | 6694911 | Yes |
| 413 | 2493 | 2493.0 | 100.77 | 100.8 | Emerging adulthood. A theory of development from the late teens through the twenties. | J J Arnett | Am Psychol | 2000 | 10842426 | Yes |
| 414 | 4981 | 2490.5 | 222.03 | 111.0 | Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. | Laurent Excoffier, Heidi E L Lischer | Mol Ecol Resour | 2010 | 21565059 | Yes |
| 415 | 2489 | 2489.0 | 74.0 | 74.0 | Neural networks and physical systems with emergent collective computational abilities. | J J Hopfield | Proc. Natl. Acad. Sci. U.S.A. | 1982 | 6953413 | Yes |
| 416 | 2478 | 2478.0 | 76.63 | 76.6 | Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? | Kim A Brogden | Nat. Rev. Microbiol. | 2005 | 15703760 | No |
| 417 | 2474 | 2474.0 | 68.84 | 68.8 | Wound healing--aiming for perfect skin regeneration. | P Martin | Science | 1997 | 9082989 | No |
| 418 | 2472 | 2472.0 | 75.42 | 75.4 | Biologic basis for interleukin-1 in disease. | C A Dinarello | Blood | 1996 | 8630372 | No |
| 419 | 2470 | 2470.0 | 0.0 | 0.0 | The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. | T NASH | Biochem. J. | 1953 | 13105648 | Yes |
| 420 | 2465 | 2465.0 | 71.45 | 71.5 | WHAT IF: a molecular modeling and drug design program. | G Vriend | J Mol Graph | 1990 | 2268628 | Yes |
| 421 | 2455 | 2455.0 | 77.35 | 77.3 | Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. | Y X Fu | Genetics | 1997 | 9335623 | Yes |
| 422 | 4902 | 2451.0 | 132.33 | 66.2 | Inference of macromolecular assemblies from crystalline state. | Evgeny Krissinel, Kim Henrick | J. Mol. Biol. | 2007 | 17681537 | Yes |
| 423 | 4896 | 2448.0 | 172.51 | 86.3 | RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. | Bo Li, Colin N Dewey | BMC Bioinformatics | 2011 | 21816040 | Yes |
| 424 | 4888 | 2444.0 | 151.74 | 75.9 | The basics of epithelial-mesenchymal transition. | Raghu Kalluri, Robert A Weinberg | J. Clin. Invest. | 2009 | 19487818 | No |
| 425 | 4878 | 2439.0 | 120.19 | 60.1 | Toll-like receptor signalling. | Shizuo Akira, Kiyoshi Takeda | Nat. Rev. Immunol. | 2004 | 15229469 | No |
| 426 | 2435 | 2435.0 | 85.31 | 85.3 | Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. | R W Mahley | Science | 1988 | 3283935 | No |
| 427 | 2428 | 2428.0 | 76.24 | 76.2 | The heat-shock response. | S Lindquist | Annu. Rev. Biochem. | 1986 | 2427013 | No |
| 428 | 7279 | 2426.3 | 223.69 | 74.6 | MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. | Sudhir Kumar, Koichiro Tamura, Masatoshi Nei | Brief. Bioinformatics | 2004 | 15260895 | Yes |
| 429 | 2424 | 2424.0 | 72.3 | 72.3 | How do you feel? Interoception: the sense of the physiological condition of the body. | A D Craig | Nat. Rev. Neurosci. | 2002 | 12154366 | No |
| 430 | 2420 | 2420.0 | 64.19 | 64.2 | Folding DNA to create nanoscale shapes and patterns. | Paul W K Rothemund | Nature | 2006 | 16541064 | Yes |
| 431 | 4833 | 2416.5 | 0.0 | 0.0 | Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. | D H HUBEL, T N WIESEL | J. Physiol. (Lond.) | 1962 | 14449617 | Yes |
| 432 | 2416 | 2416.0 | 78.36 | 78.4 | Hay fever, hygiene, and household size. | D P Strachan | BMJ | 1989 | 2513902 | Yes |
| 433 | 2413 | 2413.0 | 0.0 | 0.0 | The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. | J F WOESSNER | Arch. Biochem. Biophys. | 1961 | 13786180 | Yes |
| 434 | 4826 | 2413.0 | 225.12 | 112.6 | Management of hepatocellular carcinoma: an update. | Jordi Bruix, Morris Sherman | Hepatology | 2011 | 21374666 | No |
| 435 | 4825 | 2412.5 | 121.55 | 60.8 | Angiogenesis in cancer and other diseases. | P Carmeliet, R K Jain | Nature | 2000 | 11001068 | No |
| 436 | 4809 | 2404.5 | 235.3 | 117.7 | The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. | I F Benzie, J J Strain | Anal. Biochem. | 1996 | 8660627 | Yes |
| 437 | 4806 | 2403.0 | 168.59 | 84.3 | "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. | A P Feinberg, B Vogelstein | Anal. Biochem. | 1984 | 6329026 | Yes |
| 438 | 14414 | 2402.3 | 1212.26 | 202.0 | Global cancer statistics, 2012. | Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin Jemal | CA Cancer J Clin | 2015 | 25651787 | Yes |
| 439 | 2400 | 2400.0 | 125.9 | 125.9 | Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. | O W Griffith | Anal. Biochem. | 1980 | 7416462 | Yes |
| 440 | 9598 | 2399.5 | 396.19 | 99.0 | Cancer statistics, 2010. | Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth Ward | CA Cancer J Clin | 2010 | 20610543 | Yes |
| 441 | 4797 | 2398.5 | 122.93 | 61.5 | MicroRNA signatures in human cancers. | George A Calin, Carlo M Croce | Nat. Rev. Cancer | 2006 | 17060945 | No |
| 442 | 2394 | 2394.0 | 72.62 | 72.6 | The pathobiology of diabetic complications: a unifying mechanism. | Michael Brownlee | Diabetes | 2005 | 15919781 | No |
| 443 | 4783 | 2391.5 | 0.0 | 0.0 | Human malaria parasites in continuous culture. | W Trager, J B Jensen | Science | 1976 | 781840 | Yes |
| 444 | 2389 | 2389.0 | 97.87 | 97.9 | Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. | Ilan H Meyer | Psychol Bull | 2003 | 12956539 | No |
| 445 | 2388 | 2388.0 | 95.33 | 95.3 | No adjustments are needed for multiple comparisons. | K J Rothman | Epidemiology | 1990 | 2081237 | Yes |
| 446 | 2383 | 2383.0 | 63.41 | 63.4 | Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. | H F Dvorak | N. Engl. J. Med. | 1986 | 3537791 | No |
| 447 | 4766 | 2383.0 | 131.19 | 65.6 | The plant immune system. | Jonathan D G Jones, Jeffery L Dangl | Nature | 2006 | 17108957 | No |
| 448 | 2379 | 2379.0 | 0.0 | 0.0 | DISC ELECTROPHORESIS. I. BACKGROUND AND THEORY. | L ORNSTEIN | Ann. N. Y. Acad. Sci. | 1964 | 14240533 | Yes |
| 449 | 2372 | 2372.0 | 0.0 | 0.0 | Spectroscopic determination of tryptophan and tyrosine in proteins. | H Edelhoch | Biochemistry | 1967 | 6049437 | Yes |
| 450 | 2372 | 2372.0 | 61.7 | 61.7 | Tolerance, danger, and the extended family. | P Matzinger | Annu. Rev. Immunol. | 1994 | 8011301 | No |
| 451 | 2369 | 2369.0 | 0.0 | 0.0 | Statistical estimations in enzyme kinetics. | G N WILKINSON | Biochem. J. | 1961 | 13785321 | Yes |
| 452 | 4722 | 2361.0 | 0.0 | 0.0 | A new method for sequencing DNA. | A M Maxam, W Gilbert | Proc. Natl. Acad. Sci. U.S.A. | 1977 | 265521 | Yes |
| 453 | 4721 | 2360.5 | 91.42 | 45.7 | The language of covalent histone modifications. | B D Strahl, C D Allis | Nature | 2000 | 10638745 | Yes |
| 454 | 4721 | 2360.5 | 143.14 | 71.6 | Voxel-based morphometry--the methods. | J Ashburner, K J Friston | Neuroimage | 2000 | 10860804 | No |
| 455 | 2357 | 2357.0 | 59.48 | 59.5 | Inflammatory bowel disease. | Daniel K Podolsky | N. Engl. J. Med. | 2002 | 12167685 | No |
| 456 | 2356 | 2356.0 | 89.91 | 89.9 | Functions of DNA methylation: islands, start sites, gene bodies and beyond. | Peter A Jones | Nat. Rev. Genet. | 2012 | 22641018 | No |
| 457 | 2354 | 2354.0 | 56.27 | 56.3 | One-step gene disruption in yeast. | R J Rothstein | Meth. Enzymol. | 1983 | 6310324 | Yes |
| 458 | 4705 | 2352.5 | 0.0 | 0.0 | The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. | R C Graham, M J Karnovsky | J. Histochem. Cytochem. | 1966 | 5962951 | Yes |
| 459 | 2351 | 2351.0 | 50.15 | 50.1 | RNA interference. | Gregory J Hannon | Nature | 2002 | 12110901 | No |
| 460 | 2346 | 2346.0 | 58.71 | 58.7 | Angiogenesis in health and disease. | Peter Carmeliet | Nat. Med. | 2003 | 12778163 | No |
| 461 | 2345 | 2345.0 | 61.09 | 61.1 | CpG-rich islands and the function of DNA methylation. | A P Bird | Nature | 1986 | 2423876 | No |
| 462 | 2344 | 2344.0 | 57.22 | 57.2 | Protein folding and misfolding. | Christopher M Dobson | Nature | 2003 | 14685248 | No |
| 463 | 2343 | 2343.0 | 67.17 | 67.2 | Chemokines--chemotactic cytokines that mediate inflammation. | A D Luster | N. Engl. J. Med. | 1998 | 9459648 | No |
| 464 | 2341 | 2341.0 | 74.85 | 74.8 | Mesenchymal stem cells. | A I Caplan | J. Orthop. Res. | 1991 | 1870029 | Yes |
| 465 | 2337 | 2337.0 | 58.7 | 58.7 | Mechanisms of angiogenesis and arteriogenesis. | P Carmeliet | Nat. Med. | 2000 | 10742145 | No |
| 466 | 2335 | 2335.0 | 104.04 | 104.0 | Inositol trisphosphate and diacylglycerol as second messengers. | M J Berridge | Biochem. J. | 1984 | 6146314 | No |
| 467 | 2333 | 2333.0 | 0.0 | 0.0 | Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. | J D Rowley | Nature | 1973 | 4126434 | Yes |
| 468 | 2326 | 2326.0 | 77.56 | 77.6 | Phase separation of integral membrane proteins in Triton X-114 solution. | C Bordier | J. Biol. Chem. | 1981 | 6257680 | Yes |
| 469 | 4650 | 2325.0 | 107.77 | 53.9 | Emergence of scaling in random networks | Barabasi, Albert | Science | 1999 | 10521342 | Yes |
| 470 | 2323 | 2323.0 | 125.51 | 125.5 | Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. | T E Moffitt | Psychol Rev | 1993 | 8255953 | No |
| 471 | 2314 | 2314.0 | 52.01 | 52.0 | The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. | Isaiah J Fidler | Nat. Rev. Cancer | 2003 | 12778135 | No |
| 472 | 6925 | 2308.3 | 201.75 | 67.2 | Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. | Da Wei Huang, Brad T Sherman, Richard A Lempicki | Nucleic Acids Res. | 2009 | 19033363 | Yes |
| 473 | 2307 | 2307.0 | 77.29 | 77.3 | EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. | W Klimesch | Brain Res. Brain Res. Rev. | 1999 | 10209231 | No |
| 474 | 2305 | 2305.0 | 58.13 | 58.1 | Cardiac excitation-contraction coupling. | Donald M Bers | Nature | 2002 | 11805843 | No |
| 475 | 4606 | 2303.0 | 179.82 | 89.9 | The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. | J Vieira, J Messing | Gene | 1982 | 6295879 | Yes |
| 476 | 6907 | 2302.3 | 191.47 | 63.8 | TopHat: discovering splice junctions with RNA-Seq. | Cole Trapnell, Lior Pachter, Steven L Salzberg | Bioinformatics | 2009 | 19289445 | Yes |
| 477 | 4604 | 2302.0 | 117.88 | 58.9 | Oncomirs - microRNAs with a role in cancer. | Aurora Esquela-Kerscher, Frank J Slack | Nat. Rev. Cancer | 2006 | 16557279 | No |
| 478 | 9176 | 2294.0 | 263.33 | 65.8 | Improved methods for building protein models in electron density maps and the location of errors in these models. | T A Jones, J Y Zou, S W Cowan, M Kjeldgaard | Acta Crystallogr., A, Found. Crystallogr. | 1991 | 2025413 | Yes |
| 479 | 2294 | 2294.0 | 65.1 | 65.1 | Obesity as a medical problem. | P G Kopelman | Nature | 2000 | 10766250 | No |
| 480 | 2292 | 2292.0 | 0.0 | 0.0 | The magical number seven plus or minus two: some limits on our capacity for processing information. | G A MILLER | Psychol Rev | 1956 | 13310704 | Yes |
| 481 | 2287 | 2287.0 | 54.07 | 54.1 | Alzheimer's disease is a synaptic failure. | Dennis J Selkoe | Science | 2002 | 12399581 | No |
| 482 | 9130 | 2282.5 | 218.11 | 54.5 | Cluster analysis and display of genome-wide expression patterns. | M B Eisen, P T Spellman, P O Brown, D Botstein | Proc. Natl. Acad. Sci. U.S.A. | 1998 | 9843981 | Yes |
| 483 | 2281 | 2281.0 | 51.9 | 51.9 | Toll-like receptors and innate immunity. | R Medzhitov | Nat. Rev. Immunol. | 2001 | 11905821 | No |
| 484 | 2279 | 2279.0 | 48.59 | 48.6 | Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. | P Schuck | Biophys. J. | 2000 | 10692345 | Yes |
| 485 | 2276 | 2276.0 | 63.96 | 64.0 | Photoelectrochemical cells. | M Grätzel | Nature | 2001 | 11713540 | Yes |
| 486 | 2271 | 2271.0 | 74.2 | 74.2 | Optimal two-stage designs for phase II clinical trials. | R Simon | Control Clin Trials | 1989 | 2702835 | Yes |
| 487 | 2271 | 2271.0 | 82.85 | 82.8 | Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. | Thomas Welton | Chem. Rev. | 1999 | 11849019 | Yes |
| 488 | 2270 | 2270.0 | 90.02 | 90.0 | Health promotion by social cognitive means. | Albert Bandura | Health Educ Behav | 2004 | 15090118 | Yes |
| 489 | 4535 | 2267.5 | 146.9 | 73.5 | TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. | T R Mosmann, R L Coffman | Annu. Rev. Immunol. | 1989 | 2523712 | No |
| 490 | 4514 | 2257.0 | 151.36 | 75.7 | ESTIMATING F-STATISTICS FOR THE ANALYSIS OF POPULATION STRUCTURE. | B S Weir, C Clark Cockerham | Evolution | 1984 | 28563791 | Yes |
| 491 | 2252 | 2252.0 | 88.31 | 88.3 | Hepatocellular carcinoma. | Hashem B El-Serag | N. Engl. J. Med. | 2011 | 21992124 | No |
| 492 | 2251 | 2251.0 | 87.53 | 87.5 | Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. | Sarah E Barlow | Pediatrics | 2007 | 18055651 | Yes |
| 493 | 9001 | 2250.2 | 444.35 | 111.1 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | Ann. Intern. Med. | 2009 | 19622511 | No |
| 494 | 2249 | 2249.0 | 50.5 | 50.5 | Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. | Shimon Sakaguchi | Annu. Rev. Immunol. | 2004 | 15032588 | No |
| 495 | 2248 | 2248.0 | 52.17 | 52.2 | Interleukin-12 and the regulation of innate resistance and adaptive immunity. | Giorgio Trinchieri | Nat. Rev. Immunol. | 2003 | 12563297 | No |
| 496 | 2246 | 2246.0 | 0.0 | 0.0 | Estimation of the molecular weights of proteins by Sephadex gel-filtration. | P Andrews | Biochem. J. | 1964 | 4158310 | Yes |
| 497 | 4487 | 2243.5 | 0.0 | 0.0 | Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. | H Aviv, P Leder | Proc. Natl. Acad. Sci. U.S.A. | 1972 | 4504350 | Yes |
| 498 | 8972 | 2243.0 | 459.77 | 114.9 | APACHE II: a severity of disease classification system. | W A Knaus, E A Draper, D P Wagner, J E Zimmerman | Crit. Care Med. | 1985 | 3928249 | Yes |
| 499 | 2225 | 2225.0 | 61.51 | 61.5 | Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. | S A Bustin | J. Mol. Endocrinol. | 2000 | 11013345 | No |
| 500 | 2223 | 2223.0 | 105.37 | 105.4 | Half a century of research on the Stroop effect: an integrative review. | C M MacLeod | Psychol Bull | 1991 | 2034749 | No |
| 501 | 2223 | 2223.0 | 46.68 | 46.7 | Genome maintenance mechanisms for preventing cancer. | J H Hoeijmakers | Nature | 2001 | 11357144 | No |
| 502 | 4446 | 2223.0 | 146.95 | 73.5 | Projections of global mortality and burden of disease from 2002 to 2030. | Colin D Mathers, Dejan Loncar | PLoS Med. | 2006 | 17132052 | Yes |
| 503 | 2218 | 2218.0 | 84.1 | 84.1 | Estimation of metabolite concentrations from localized in vivo proton NMR spectra. | S W Provencher | Magn Reson Med | 1993 | 8139448 | Yes |
| 504 | 4432 | 2216.0 | 0.0 | 0.0 | A simplified method of evaluating dose-effect experiments. | J T LITCHFIELD, F WILCOXON | J. Pharmacol. Exp. Ther. | 1949 | 18152921 | Yes |
| 505 | 2215 | 2215.0 | 75.27 | 75.3 | ABC transporters: from microorganisms to man. | C F Higgins | Annu. Rev. Cell Biol. | 1992 | 1282354 | No |
| 506 | 4423 | 2211.5 | 122.98 | 61.5 | Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. | C Tuerk, L Gold | Science | 1990 | 2200121 | Yes |
| 507 | 4414 | 2207.0 | 125.59 | 62.8 | Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. | D B Smith, K S Johnson | Gene | 1988 | 3047011 | Yes |
| 508 | 2205 | 2205.0 | 40.71 | 40.7 | Mechanisms underlying ubiquitination. | C M Pickart | Annu. Rev. Biochem. | 2001 | 11395416 | No |
| 509 | 4396 | 2198.0 | 175.59 | 87.8 | Tissue engineering. | R Langer, J P Vacanti | Science | 1993 | 8493529 | No |
| 510 | 2195 | 2195.0 | 55.71 | 55.7 | Nuclear factor-kappaB in cancer development and progression. | Michael Karin | Nature | 2006 | 16724054 | No |
| 511 | 2193 | 2193.0 | 126.68 | 126.7 | The short-form McGill Pain Questionnaire. | R Melzack | Pain | 1987 | 3670870 | Yes |
| 512 | 2191 | 2191.0 | 59.97 | 60.0 | Molecular chaperones in cellular protein folding. | F U Hartl | Nature | 1996 | 8637592 | No |
| 513 | 4378 | 2189.0 | 120.36 | 60.2 | Caspases: enemies within. | N A Thornberry, Y Lazebnik | Science | 1998 | 9721091 | No |
| 514 | 2187 | 2187.0 | 63.26 | 63.3 | Cadherin cell adhesion receptors as a morphogenetic regulator. | M Takeichi | Science | 1991 | 2006419 | No |
| 515 | 2185 | 2185.0 | 0.0 | 0.0 | A gene complex controlling segmentation in Drosophila. | E B Lewis | Nature | 1978 | 103000 | Yes |
| 516 | 2185 | 2185.0 | 0.0 | 0.0 | Gene action in the X-chromosome of the mouse (Mus musculus L.). | M F LYON | Nature | 1961 | 13764598 | Yes |
| 517 | 15276 | 2182.3 | 386.44 | 55.2 | UCSF Chimera--a visualization system for exploratory research and analysis. | Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E Ferrin | J Comput Chem | 2004 | 15264254 | Yes |
| 518 | 2182 | 2182.0 | 51.53 | 51.5 | Papillomaviruses and cancer: from basic studies to clinical application. | Harald zur Hausen | Nat. Rev. Cancer | 2002 | 12044010 | No |
| 519 | 8717 | 2179.2 | 0.0 | 0.0 | Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. | P W Rigby, M Dieckmann, C Rhodes, P Berg | J. Mol. Biol. | 1977 | 881736 | Yes |
| 520 | 2171 | 2171.0 | 0.0 | 0.0 | Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. | S W Kessler | J. Immunol. | 1975 | 1102604 | Yes |
| 521 | 2171 | 2171.0 | 0.0 | 0.0 | Perceived exertion as an indicator of somatic stress. | G Borg | Scand J Rehabil Med | 1970 | 5523831 | Yes |
| 522 | 6500 | 2166.7 | 234.42 | 78.1 | Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. | Y Gavrieli, Y Sherman, S A Ben-Sasson | J. Cell Biol. | 1992 | 1400587 | Yes |
| 523 | 2165 | 2165.0 | 58.75 | 58.8 | Mitochondrial formation of reactive oxygen species. | Julio F Turrens | J. Physiol. (Lond.) | 2003 | 14561818 | No |
| 524 | 4320 | 2160.0 | 198.52 | 99.3 | Longitudinal data analysis for discrete and continuous outcomes. | S L Zeger, K Y Liang | Biometrics | 1986 | 3719049 | Yes |
| 525 | 2160 | 2160.0 | 65.81 | 65.8 | Predictive reward signal of dopamine neurons. | W Schultz | J. Neurophysiol. | 1998 | 9658025 | No |
| 526 | 2159 | 2159.0 | 59.19 | 59.2 | Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. | Ting-Chao Chou | Pharmacol. Rev. | 2006 | 16968952 | No |
| 527 | 2155 | 2155.0 | 0.0 | 0.0 | On the number of segregating sites in genetical models without recombination. | G A Watterson | Theor Popul Biol | 1975 | 1145509 | Yes |
| 528 | 4307 | 2153.5 | 0.0 | 0.0 | PERIODONTAL DISEASE IN PREGNANCY. II. CORRELATION BETWEEN ORAL HYGIENE AND PERIODONTAL CONDTION. | J SILNESS, H LOE | Acta Odontol. Scand. | 1964 | 14158464 | Yes |
| 529 | 2153 | 2153.0 | 0.0 | 0.0 | Pharmacological implications of microsomal enzyme induction. | A H Conney | Pharmacol. Rev. | 1967 | 4383307 | Yes |
| 530 | 2153 | 2153.0 | 56.4 | 56.4 | Cell adhesion: the molecular basis of tissue architecture and morphogenesis. | B M Gumbiner | Cell | 1996 | 8608588 | No |
| 531 | 2147 | 2147.0 | 48.76 | 48.8 | The danger model: a renewed sense of self. | Polly Matzinger | Science | 2002 | 11951032 | Yes |
| 532 | 4291 | 2145.5 | 105.17 | 52.6 | Establishment in culture of pluripotential cells from mouse embryos. | M J Evans, M H Kaufman | Nature | 1981 | 7242681 | Yes |
| 533 | 2145 | 2145.0 | 92.66 | 92.7 | The processing-speed theory of adult age differences in cognition. | T A Salthouse | Psychol Rev | 1996 | 8759042 | No |
| 534 | 2145 | 2145.0 | 63.15 | 63.1 | The genetic legacy of the Quaternary ice ages. | G Hewitt | Nature | 2000 | 10879524 | No |
| 535 | 2144 | 2144.0 | 76.19 | 76.2 | Gene regulation by steroid hormones. | M Beato | Cell | 1989 | 2644044 | No |
| 536 | 2141 | 2141.0 | 43.8 | 43.8 | Wnt signaling and cancer. | P Polakis | Genes Dev. | 2000 | 10921899 | No |
| 537 | 2137 | 2137.0 | 0.0 | 0.0 | Analysis of gene diversity in subdivided populations. | M Nei | Proc. Natl. Acad. Sci. U.S.A. | 1973 | 4519626 | Yes |
| 538 | 4272 | 2136.0 | 111.83 | 55.9 | Oxidants, oxidative stress and the biology of ageing. | T Finkel, N J Holbrook | Nature | 2000 | 11089981 | No |
| 539 | 4265 | 2132.5 | 0.0 | 0.0 | Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. | C Beauchamp, I Fridovich | Anal. Biochem. | 1971 | 4943714 | Yes |
| 540 | 6391 | 2130.3 | 261.99 | 87.3 | Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. | R A Deyo, D C Cherkin, M A Ciol | J Clin Epidemiol | 1992 | 1607900 | Yes |
| 541 | 2130 | 2130.0 | 64.16 | 64.2 | Cell death during development of the nervous system. | R W Oppenheim | Annu. Rev. Neurosci. | 1991 | 2031577 | No |
| 542 | 2123 | 2123.0 | 65.59 | 65.6 | Recent advances with liposomes as pharmaceutical carriers. | Vladimir P Torchilin | Nat Rev Drug Discov | 2005 | 15688077 | No |
| 543 | 4234 | 2117.0 | 173.32 | 86.7 | Computed tomography--an increasing source of radiation exposure. | David J Brenner, Eric J Hall | N. Engl. J. Med. | 2007 | 18046031 | No |
| 544 | 6344 | 2114.7 | 290.81 | 96.9 | Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. | R M Palmer, A G Ferrige, S Moncada | Nature | 1987 | 3495737 | Yes |
| 545 | 4225 | 2112.5 | 114.58 | 57.3 | High-efficiency transformation of mammalian cells by plasmid DNA. | C Chen, H Okayama | Mol. Cell. Biol. | 1987 | 3670292 | Yes |
| 546 | 4224 | 2112.0 | 124.45 | 62.2 | Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. | T C Chou, P Talalay | Adv. Enzyme Regul. | 1984 | 6382953 | Yes |
| 547 | 2112 | 2112.0 | 54.65 | 54.6 | TGFbeta in Cancer. | Joan Massagué | Cell | 2008 | 18662538 | No |
| 548 | 2111 | 2111.0 | 0.0 | 0.0 | A relation between non-esterified fatty acids in plasma and the metabolism of glucose. | V P DOLE | J. Clin. Invest. | 1956 | 13286333 | Yes |
| 549 | 4218 | 2109.0 | 134.4 | 67.2 | Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. | F W Studier, B A Moffatt | J. Mol. Biol. | 1986 | 3537305 | Yes |
| 550 | 6320 | 2106.7 | 210.46 | 70.2 | Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. | G Evanno, S Regnaut, J Goudet | Mol. Ecol. | 2005 | 15969739 | Yes |
| 551 | 2106 | 2106.0 | 71.88 | 71.9 | Non-coding RNAs in human disease. | Manel Esteller | Nat. Rev. Genet. | 2011 | 22094949 | No |
| 552 | 2105 | 2105.0 | 0.0 | 0.0 | The glomerular permeability determined by dextran clearance using Sephadex gel filtration. | C E Mogensen | Scand. J. Clin. Lab. Invest. | 1968 | 5637478 | Yes |
| 553 | 2105 | 2105.0 | 85.97 | 86.0 | Psychometric properties of the strengths and difficulties questionnaire. | R Goodman | J Am Acad Child Adolesc Psychiatry | 2001 | 11699809 | Yes |
| 554 | 6302 | 2100.7 | 155.38 | 51.8 | The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. | R C Lee, R L Feinbaum, V Ambros | Cell | 1993 | 8252621 | Yes |
| 555 | 4197 | 2098.5 | 96.47 | 48.2 | Innate immune recognition. | Charles A Janeway, Ruslan Medzhitov | Annu. Rev. Immunol. | 2002 | 11861602 | No |
| 556 | 6290 | 2096.7 | 1406.94 | 469.0 | Cancer statistics, 2018. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2018 | 29313949 | Yes |
| 557 | 2093 | 2093.0 | 0.0 | 0.0 | EQUILIBRIUM ULTRACENTRIFUGATION OF DILUTE SOLUTIONS. | D A YPHANTIS | Biochemistry | 1964 | 14155091 | Yes |
| 558 | 6245 | 2081.7 | 197.21 | 65.7 | Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. | C M Gorman, L F Moffat, B H Howard | Mol. Cell. Biol. | 1982 | 6960240 | Yes |
| 559 | 4163 | 2081.5 | 180.82 | 90.4 | Measuring agreement in method comparison studies. | J M Bland, D G Altman | Stat Methods Med Res | 1999 | 10501650 | No |
| 560 | 4159 | 2079.5 | 190.14 | 95.1 | A method of comparing the areas under receiver operating characteristic curves derived from the same cases. | J A Hanley, B J McNeil | Radiology | 1983 | 6878708 | Yes |
| 561 | 8312 | 2078.0 | 556.87 | 139.2 | Cancer statistics, 2014. | Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin Jemal | CA Cancer J Clin | 2014 | 24399786 | Yes |
| 562 | 2074 | 2074.0 | 81.37 | 81.4 | Delayed neuronal death in the gerbil hippocampus following ischemia. | T Kirino | Brain Res. | 1982 | 7093691 | Yes |
| 563 | 4147 | 2073.5 | 0.0 | 0.0 | Assessment of outcome after severe brain damage. | B Jennett, M Bond | Lancet | 1975 | 46957 | Yes |
| 564 | 2073 | 2073.0 | 0.0 | 0.0 | A protein binding assay for adenosine 3':5'-cyclic monophosphate. | A G Gilman | Proc. Natl. Acad. Sci. U.S.A. | 1970 | 4318781 | Yes |
| 565 | 4144 | 2072.0 | 125.85 | 62.9 | Fast and accurate long-read alignment with Burrows-Wheeler transform. | Heng Li, Richard Durbin | Bioinformatics | 2010 | 20080505 | Yes |
| 566 | 4135 | 2067.5 | 163.86 | 81.9 | mTOR signaling in growth control and disease. | Mathieu Laplante, David M Sabatini | Cell | 2012 | 22500797 | No |
| 567 | 4132 | 2066.0 | 117.52 | 58.8 | In vitro selection of RNA molecules that bind specific ligands. | A D Ellington, J W Szostak | Nature | 1990 | 1697402 | Yes |
| 568 | 2065 | 2065.0 | 49.47 | 49.5 | Principles of CDK regulation. | D O Morgan | Nature | 1995 | 7877684 | No |
| 569 | 2061 | 2061.0 | 56.34 | 56.3 | Memory--a century of consolidation. | J L McGaugh | Science | 2000 | 10634773 | No |
| 570 | 4113 | 2056.5 | 0.0 | 0.0 | Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. | J Glowinski, L L Iversen | J. Neurochem. | 1966 | 5950056 | Yes |
| 571 | 8194 | 2048.5 | 312.47 | 78.1 | Establishing a standard definition for child overweight and obesity worldwide: international survey. | T J Cole, M C Bellizzi, K M Flegal, W H Dietz | BMJ | 2000 | 10797032 | Yes |
| 572 | 2048 | 2048.0 | 0.0 | 0.0 | Models for the specific adhesion of cells to cells. | G I Bell | Science | 1978 | 347575 | No |
| 573 | 6132 | 2044.0 | 186.75 | 62.2 | Understanding the Warburg effect: the metabolic requirements of cell proliferation. | Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson | Science | 2009 | 19460998 | No |
| 574 | 2039 | 2039.0 | 76.05 | 76.0 | Primate models of movement disorders of basal ganglia origin. | M R DeLong | Trends Neurosci. | 1990 | 1695404 | No |
| 575 | 2037 | 2037.0 | 47.42 | 47.4 | Getting started with yeast. | F Sherman | Meth. Enzymol. | 1991 | 2005794 | Yes |
| 576 | 2031 | 2031.0 | 0.0 | 0.0 | Measurement of pain. | E C Huskisson | Lancet | 1974 | 4139420 | Yes |
| 577 | 4057 | 2028.5 | 116.26 | 58.1 | Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. | D Hanahan, J Folkman | Cell | 1996 | 8756718 | No |
| 578 | 2024 | 2024.0 | 86.31 | 86.3 | Essential oils: their antibacterial properties and potential applications in foods--a review. | Sara Burt | Int. J. Food Microbiol. | 2004 | 15246235 | No |
| 579 | 4044 | 2022.0 | 138.08 | 69.0 | Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. | S Duval, R Tweedie | Biometrics | 2000 | 10877304 | Yes |
| 580 | 2021 | 2021.0 | 74.34 | 74.3 | Implications of normal brain development for the pathogenesis of schizophrenia. | D R Weinberger | Arch. Gen. Psychiatry | 1987 | 3606332 | Yes |
| 581 | 2018 | 2018.0 | 57.79 | 57.8 | Structure and function of telomeres. | E H Blackburn | Nature | 1991 | 1708110 | No |
| 582 | 4033 | 2016.5 | 0.0 | 0.0 | PERIODONTAL DISEASE IN PREGNANCY. I. PREVALENCE AND SEVERITY. | H LOE, J SILNESS | Acta Odontol. Scand. | 1963 | 14121956 | Yes |
| 583 | 4033 | 2016.5 | 135.81 | 67.9 | The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. | Taro Kawai, Shizuo Akira | Nat. Immunol. | 2010 | 20404851 | No |
| 584 | 2014 | 2014.0 | 50.34 | 50.3 | Salt and drought stress signal transduction in plants. | Jian-Kang Zhu | Annu Rev Plant Biol | 2002 | 12221975 | No |
| 585 | 4024 | 2012.0 | 262.58 | 131.3 | Revised methods for the Salmonella mutagenicity test. | D M Maron, B N Ames | Mutat. Res. | 1983 | 6341825 | Yes |
| 586 | 4022 | 2011.0 | 144.82 | 72.4 | Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. | K Tamura, M Nei | Mol. Biol. Evol. | 1993 | 8336541 | Yes |
| 587 | 2009 | 2009.0 | 54.32 | 54.3 | Prostaglandins and leukotrienes: advances in eicosanoid biology. | C D Funk | Science | 2001 | 11729303 | No |
| 588 | 2005 | 2005.0 | 58.06 | 58.1 | Origin and physiological roles of inflammation. | Ruslan Medzhitov | Nature | 2008 | 18650913 | No |
| 589 | 4007 | 2003.5 | 0.0 | 0.0 | Pain mechanisms: a new theory. | R Melzack, P D Wall | Science | 1965 | 5320816 | No |
| 590 | 4007 | 2003.5 | 139.62 | 69.8 | Adherence to medication. | Lars Osterberg, Terrence Blaschke | N. Engl. J. Med. | 2005 | 16079372 | No |
| 591 | 4002 | 2001.0 | 127.45 | 63.7 | Unified segmentation. | John Ashburner, Karl J Friston | Neuroimage | 2005 | 15955494 | Yes |
| 592 | 4000 | 2000.0 | 106.05 | 53.0 | WGCNA: an R package for weighted correlation network analysis. | Peter Langfelder, Steve Horvath | BMC Bioinformatics | 2008 | 19114008 | Yes |
| 593 | 3983 | 1991.5 | 117.52 | 58.8 | Exploring the full spectrum of macrophage activation. | David M Mosser, Justin P Edwards | Nat. Rev. Immunol. | 2008 | 19029990 | No |
| 594 | 3974 | 1987.0 | 144.03 | 72.0 | Complex brain networks: graph theoretical analysis of structural and functional systems. | Ed Bullmore, Olaf Sporns | Nat. Rev. Neurosci. | 2009 | 19190637 | No |
| 595 | 1983 | 1983.0 | 53.23 | 53.2 | Epigenetics in cancer. | Manel Esteller | N. Engl. J. Med. | 2008 | 18337604 | No |
| 596 | 5945 | 1981.7 | 0.0 | 0.0 | Immunochemical quantitation of antigens by single radial immunodiffusion. | G Mancini, A O Carbonara, J F Heremans | Immunochemistry | 1965 | 4956917 | Yes |
| 597 | 1980 | 1980.0 | 84.25 | 84.2 | Matrix metalloproteinases and their inhibitors in connective tissue remodeling. | J F Woessner | FASEB J. | 1991 | 1850705 | No |
| 598 | 5939 | 1979.7 | 160.24 | 53.4 | Pathogen recognition and innate immunity. | Shizuo Akira, Satoshi Uematsu, Osamu Takeuchi | Cell | 2006 | 16497588 | No |
| 599 | 1976 | 1976.0 | 80.31 | 80.3 | Inositol trisphosphate and diacylglycerol: two interacting second messengers. | M J Berridge | Annu. Rev. Biochem. | 1987 | 3304132 | No |
| 600 | 1974 | 1974.0 | 0.0 | 0.0 | Transduction of linked genetic characters of the host by bacteriophage P1. | E S LENNOX | Virology | 1955 | 13267987 | Yes |
| 601 | 5916 | 1972.0 | 0.0 | 0.0 | Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. | G Fairbanks, T L Steck, D F Wallach | Biochemistry | 1971 | 4326772 | Yes |
| 602 | 1972 | 1972.0 | 0.0 | 0.0 | Some factors in the interpretation of protein denaturation. | W KAUZMANN | Adv. Protein Chem. | 1959 | 14404936 | Yes |
| 603 | 1969 | 1969.0 | 0.0 | 0.0 | The genetical structure of populations. | S WRIGHT | Ann Eugen | 1951 | 24540312 | Yes |
| 604 | 3934 | 1967.0 | 85.69 | 42.8 | CDK inhibitors: positive and negative regulators of G1-phase progression. | C J Sherr, J M Roberts | Genes Dev. | 1999 | 10385618 | No |
| 605 | 1967 | 1967.0 | 0.0 | 0.0 | A study of fixation for electron microscopy. | G E PALADE | J. Exp. Med. | 1952 | 14927794 | Yes |
| 606 | 3933 | 1966.5 | 0.0 | 0.0 | Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. | S Marklund, G Marklund | Eur. J. Biochem. | 1974 | 4215654 | Yes |
| 607 | 1964 | 1964.0 | 0.0 | 0.0 | Intracellular aspects of the process of protein synthesis. | G Palade | Science | 1975 | 1096303 | No |
| 608 | 1960 | 1960.0 | 65.56 | 65.6 | Drug combination studies and their synergy quantification using the Chou-Talalay method. | Ting-Chao Chou | Cancer Res. | 2010 | 20068163 | Yes |
| 609 | 1957 | 1957.0 | 49.65 | 49.6 | Bone resorption by osteoclasts. | S L Teitelbaum | Science | 2000 | 10968780 | No |
| 610 | 1957 | 1957.0 | 54.63 | 54.6 | Vascular endothelial growth factor: basic science and clinical progress. | Napoleone Ferrara | Endocr. Rev. | 2004 | 15294883 | No |
| 611 | 1951 | 1951.0 | 57.51 | 57.5 | The resurgence of platinum-based cancer chemotherapy. | Lloyd Kelland | Nat. Rev. Cancer | 2007 | 17625587 | No |
| 612 | 1951 | 1951.0 | 82.29 | 82.3 | Ethical authorship and publishing. | Andrew J S Coats | Int. J. Cardiol. | 2009 | 19046787 | No |
| 613 | 3902 | 1951.0 | 236.2 | 118.1 | GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. | Rod Peakall, Peter E Smouse | Bioinformatics | 2012 | 22820204 | Yes |
| 614 | 3901 | 1950.5 | 88.15 | 44.1 | MicroRNAs: small RNAs with a big role in gene regulation. | Lin He, Gregory J Hannon | Nat. Rev. Genet. | 2004 | 15211354 | No |
| 615 | 3897 | 1948.5 | 159.48 | 79.7 | The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. | Stephen B Edge, Carolyn C Compton | Ann. Surg. Oncol. | 2010 | 20180029 | No |
| 616 | 1946 | 1946.0 | 63.41 | 63.4 | The transforming growth factor-beta family. | J Massagué | Annu. Rev. Cell Biol. | 1990 | 2177343 | No |
| 617 | 17502 | 1944.7 | 531.47 | 59.1 | The Sequence Alignment/Map format and SAMtools. | Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard Durbin | Bioinformatics | 2009 | 19505943 | Yes |
| 618 | 3884 | 1942.0 | 0.0 | 0.0 | The fluid mosaic model of the structure of cell membranes. | S J Singer, G L Nicolson | Science | 1972 | 4333397 | Yes |
| 619 | 1939 | 1939.0 | 0.0 | 0.0 | Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. | P MITCHELL | Nature | 1961 | 13771349 | Yes |
| 620 | 5813 | 1937.7 | 359.22 | 119.7 | HTSeq--a Python framework to work with high-throughput sequencing data. | Simon Anders, Paul Theodor Pyl, Wolfgang Huber | Bioinformatics | 2015 | 25260700 | Yes |
| 621 | 1937 | 1937.0 | 63.25 | 63.2 | The nerve growth factor 35 years later. | R Levi-Montalcini | Science | 1987 | 3306916 | No |
| 622 | 15493 | 1936.6 | 390.97 | 48.9 | The Protein Data Bank. | H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E Bourne | Nucleic Acids Res. | 2000 | 10592235 | Yes |
| 623 | 1926 | 1926.0 | 0.0 | 0.0 | A rapid radiochemical method for the determination of choline acetyltransferase. | F Fonnum | J. Neurochem. | 1975 | 1113118 | Yes |
| 624 | 1925 | 1925.0 | 48.38 | 48.4 | Molecular physiology of P2X receptors. | R Alan North | Physiol. Rev. | 2002 | 12270951 | No |
| 625 | 1920 | 1920.0 | 83.77 | 83.8 | A computational approach to edge detection. | J Canny | IEEE Trans Pattern Anal Mach Intell | 1986 | 21869365 | Yes |
| 626 | 9582 | 1916.4 | 462.26 | 92.5 | The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. | D J Buysse, C F Reynolds, T H Monk, S R Berman, D J Kupfer | Psychiatry Res | 1989 | 2748771 | Yes |
| 627 | 5747 | 1915.7 | 119.97 | 40.0 | Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. | Ron Edgar, Michael Domrachev, Alex E Lash | Nucleic Acids Res. | 2002 | 11752295 | Yes |
| 628 | 3827 | 1913.5 | 93.4 | 46.7 | Inflammation and cancer: back to Virchow? | F Balkwill, A Mantovani | Lancet | 2001 | 11229684 | No |
| 629 | 1913 | 1913.0 | 56.33 | 56.3 | Cancer nanotechnology: opportunities and challenges. | Mauro Ferrari | Nat. Rev. Cancer | 2005 | 15738981 | No |
| 630 | 1912 | 1912.0 | 65.89 | 65.9 | Two-sided confidence intervals for the single proportion: comparison of seven methods. | R G Newcombe | Stat Med | 1998 | 9595616 | Yes |
| 631 | 3823 | 1911.5 | 157.65 | 78.8 | Glutathione. | A Meister, M E Anderson | Annu. Rev. Biochem. | 1983 | 6137189 | No |
| 632 | 1908 | 1908.0 | 49.14 | 49.1 | Angiogenesis in life, disease and medicine. | Peter Carmeliet | Nature | 2005 | 16355210 | No |
| 633 | 1907 | 1907.0 | 60.0 | 60.0 | Cellular and molecular mechanisms of fibrosis. | T A Wynn | J. Pathol. | 2008 | 18161745 | No |
| 634 | 3809 | 1904.5 | 87.61 | 43.8 | Lipid rafts and signal transduction. | K Simons, D Toomre | Nat. Rev. Mol. Cell Biol. | 2000 | 11413487 | No |
| 635 | 1904 | 1904.0 | 38.47 | 38.5 | Java Treeview--extensible visualization of microarray data. | Alok J Saldanha | Bioinformatics | 2004 | 15180930 | Yes |
| 636 | 5711 | 1903.7 | 0.0 | 0.0 | THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY. | F C GREENWOOD, W M HUNTER, J S GLOVER | Biochem. J. | 1963 | 14097352 | Yes |
| 637 | 1902 | 1902.0 | 51.75 | 51.8 | MapChart: software for the graphical presentation of linkage maps and QTLs. | R E Voorrips | J. Hered. | 2002 | 12011185 | Yes |
| 638 | 3803 | 1901.5 | 147.13 | 73.6 | Inositol trisphosphate, a novel second messenger in cellular signal transduction. | M J Berridge, R F Irvine | Nature | 1984 | 6095092 | No |
| 639 | 1898 | 1898.0 | 0.0 | 0.0 | The gel-filtration behaviour of proteins related to their molecular weights over a wide range. | P Andrews | Biochem. J. | 1965 | 5862401 | Yes |
| 640 | 1892 | 1892.0 | 104.33 | 104.3 | Qualitative research. Introducing focus groups. | J Kitzinger | BMJ | 1995 | 7633241 | Yes |
| 641 | 3783 | 1891.5 | 82.93 | 41.5 | Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. | D Bonnet, J E Dick | Nat. Med. | 1997 | 9212098 | Yes |
| 642 | 5673 | 1891.0 | 0.0 | 0.0 | The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. | R J HAVEL, H A EDER, J H BRAGDON | J. Clin. Invest. | 1955 | 13252080 | Yes |
| 643 | 1890 | 1890.0 | 70.25 | 70.2 | What are the functional consequences of neurocognitive deficits in schizophrenia? | M F Green | Am J Psychiatry | 1996 | 8610818 | No |
| 644 | 3777 | 1888.5 | 153.95 | 77.0 | The neural basis of drug craving: an incentive-sensitization theory of addiction. | T E Robinson, K C Berridge | Brain Res. Brain Res. Rev. | 1993 | 8401595 | No |
| 645 | 3775 | 1887.5 | 120.46 | 60.2 | Management of hepatocellular carcinoma. | Jordi Bruix, Morris Sherman | Hepatology | 2005 | 16250051 | No |
| 646 | 1887 | 1887.0 | 0.0 | 0.0 | Satellite cell of skeletal muscle fibers. | A MAURO | J Biophys Biochem Cytol | 1961 | 13768451 | Yes |
| 647 | 3770 | 1885.0 | 104.33 | 52.2 | Autophagy in the pathogenesis of disease. | Beth Levine, Guido Kroemer | Cell | 2008 | 18191218 | No |
| 648 | 3749 | 1874.5 | 140.22 | 70.1 | Rapid isolation of high molecular weight plant DNA. | M G Murray, W F Thompson | Nucleic Acids Res. | 1980 | 7433111 | Yes |
| 649 | 1874 | 1874.0 | 92.13 | 92.1 | Measures of reliability in sports medicine and science. | W G Hopkins | Sports Med | 2000 | 10907753 | Yes |
| 650 | 3744 | 1872.0 | 158.71 | 79.4 | The L-arginine-nitric oxide pathway. | S Moncada, A Higgs | N. Engl. J. Med. | 1993 | 7504210 | No |
| 651 | 1871 | 1871.0 | 53.82 | 53.8 | Causes and consequences of microRNA dysregulation in cancer. | Carlo M Croce | Nat. Rev. Genet. | 2009 | 19763153 | No |
| 652 | 1868 | 1868.0 | 44.81 | 44.8 | Evolving concepts of rheumatoid arthritis. | Gary S Firestein | Nature | 2003 | 12748655 | No |
| 653 | 3730 | 1865.0 | 83.71 | 41.9 | Untangling the ErbB signalling network. | Y Yarden, M X Sliwkowski | Nat. Rev. Mol. Cell Biol. | 2001 | 11252954 | No |
| 654 | 1865 | 1865.0 | 133.64 | 133.6 | Executive functions. | Adele Diamond | Annu Rev Psychol | 2013 | 23020641 | No |
| 655 | 1861 | 1861.0 | 47.58 | 47.6 | A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. | Douglas C Wallace | Annu. Rev. Genet. | 2005 | 16285865 | No |
| 656 | 1858 | 1858.0 | 63.77 | 63.8 | The anatomy and taxonomy of protein structure. | J S Richardson | Adv. Protein Chem. | 1981 | 7020376 | No |
| 657 | 1856 | 1856.0 | 48.16 | 48.2 | Autophagy: process and function. | Noboru Mizushima | Genes Dev. | 2007 | 18006683 | No |
| 658 | 3708 | 1854.0 | 0.0 | 0.0 | Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. | J Sedlak, R H Lindsay | Anal. Biochem. | 1968 | 4973948 | Yes |
| 659 | 3706 | 1853.0 | 0.0 | 0.0 | The serial cultivation of human diploid cell strains. | L HAYFLICK, P S MOORHEAD | Exp. Cell Res. | 1961 | 13905658 | Yes |
| 660 | 1852 | 1852.0 | 41.93 | 41.9 | Tumour-educated macrophages promote tumour progression and metastasis. | Jeffrey W Pollard | Nat. Rev. Cancer | 2004 | 14708027 | No |
| 661 | 3702 | 1851.0 | 81.65 | 40.8 | The phosphatidylinositol 3-Kinase AKT pathway in human cancer. | Igor Vivanco, Charles L Sawyers | Nat. Rev. Cancer | 2002 | 12094235 | No |
| 662 | 3700 | 1850.0 | 114.87 | 57.4 | Calculation of protein extinction coefficients from amino acid sequence data. | S C Gill, P H von Hippel | Anal. Biochem. | 1989 | 2610349 | Yes |
| 663 | 3695 | 1847.5 | 0.0 | 0.0 | Electrochemical photolysis of water at a semiconductor electrode. | A Fujishima, K Honda | Nature | 1972 | 12635268 | Yes |
| 664 | 3691 | 1845.5 | 0.0 | 0.0 | Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. | L A Greene, A S Tischler | Proc. Natl. Acad. Sci. U.S.A. | 1976 | 1065897 | Yes |
| 665 | 1845 | 1845.0 | 58.43 | 58.4 | The magical number 4 in short-term memory: a reconsideration of mental storage capacity. | N Cowan | Behav Brain Sci | 2001 | 11515286 | Yes |
| 666 | 1840 | 1840.0 | 58.4 | 58.4 | Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. | E C Butcher | Cell | 1991 | 1760836 | No |
| 667 | 1837 | 1837.0 | 0.0 | 0.0 | Colorimetric assay of catalase. | A K Sinha | Anal. Biochem. | 1972 | 4556490 | Yes |
| 668 | 7345 | 1836.2 | 353.77 | 88.4 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | BMJ | 2009 | 19622551 | No |
| 669 | 3672 | 1836.0 | 0.0 | 0.0 | A general method applicable to the search for similarities in the amino acid sequence of two proteins. | S B Needleman, C D Wunsch | J. Mol. Biol. | 1970 | 5420325 | Yes |
| 670 | 1834 | 1834.0 | 0.0 | 0.0 | On estimating the relation between blood group and disease. | B WOOLF | Ann. Hum. Genet. | 1955 | 14388528 | Yes |
| 671 | 1833 | 1833.0 | 0.0 | 0.0 | [Rapid physiological coagulation method in determination of fibrinogen]. | A CLAUSS | Acta Haematol. | 1957 | 13434757 | Yes |
| 672 | 1830 | 1830.0 | 47.61 | 47.6 | G1 phase progression: cycling on cue. | C J Sherr | Cell | 1994 | 7954821 | No |
| 673 | 1830 | 1830.0 | 52.44 | 52.4 | Ischemic cell death in brain neurons. | P Lipton | Physiol. Rev. | 1999 | 10508238 | No |
| 674 | 1827 | 1827.0 | 0.0 | 0.0 | Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. | L SVENNERHOLM | Biochim. Biophys. Acta | 1957 | 13436486 | Yes |
| 675 | 3653 | 1826.5 | 94.77 | 47.4 | Death receptors: signaling and modulation. | A Ashkenazi, V M Dixit | Science | 1998 | 9721089 | No |
| 676 | 1826 | 1826.0 | 54.41 | 54.4 | Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. | G P Smith | Science | 1985 | 4001944 | Yes |
| 677 | 1825 | 1825.0 | 44.39 | 44.4 | Universal control mechanism regulating onset of M-phase. | P Nurse | Nature | 1990 | 2138713 | No |
| 678 | 1824 | 1824.0 | 65.21 | 65.2 | Japanese Classification of Gastric Carcinoma - 2nd English Edition - | Japanese Gastric Cancer Association | Gastric Cancer | 1998 | 11957040 | Yes |
| 679 | 3646 | 1823.0 | 85.16 | 42.6 | A novel genetic system to detect protein-protein interactions. | S Fields, O Song | Nature | 1989 | 2547163 | Yes |
| 680 | 1821 | 1821.0 | 72.72 | 72.7 | SF-36 health survey update. | J E Ware | Spine | 2000 | 11124729 | No |
| 681 | 1815 | 1815.0 | 88.92 | 88.9 | You want to measure coping but your protocol's too long: consider the brief COPE. | C S Carver | Int J Behav Med | 1997 | 16250744 | Yes |
| 682 | 3630 | 1815.0 | 95.31 | 47.7 | Signal integration in the endoplasmic reticulum unfolded protein response. | David Ron, Peter Walter | Nat. Rev. Mol. Cell Biol. | 2007 | 17565364 | No |
| 683 | 1814 | 1814.0 | 46.36 | 46.4 | Mitochondrial diseases in man and mouse. | D C Wallace | Science | 1999 | 10066162 | No |
| 684 | 10871 | 1811.8 | 292.75 | 48.8 | Phaser crystallographic software. | Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J Read | J Appl Crystallogr | 2007 | 19461840 | Yes |
| 685 | 1811 | 1811.0 | 85.9 | 85.9 | Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. | Joseph P Weir | J Strength Cond Res | 2005 | 15705040 | No |
| 686 | 1809 | 1809.0 | 40.44 | 40.4 | The molecular biology of memory storage: a dialogue between genes and synapses. | E R Kandel | Science | 2001 | 11691980 | No |
| 687 | 1809 | 1809.0 | 0.0 | 0.0 | A RAPID PERMETHYLATION OF GLYCOLIPID, AND POLYSACCHARIDE CATALYZED BY METHYLSULFINYL CARBANION IN DIMETHYL SULFOXIDE. | S HAKOMORI | J. Biochem. | 1964 | 14135466 | Yes |
| 688 | 3612 | 1806.0 | 80.07 | 40.0 | Mechanisms of TGF-beta signaling from cell membrane to the nucleus. | Yigong Shi, Joan Massagué | Cell | 2003 | 12809600 | No |
| 689 | 1804 | 1804.0 | 0.0 | 0.0 | The information capacity of the human motor system in controlling the amplitude of movement. | P M FITTS | J Exp Psychol | 1954 | 13174710 | Yes |
| 690 | 3607 | 1803.5 | 174.55 | 87.3 | Self-rated health and mortality: a review of twenty-seven community studies. | E L Idler, Y Benyamini | J Health Soc Behav | 1997 | 9097506 | No |
| 691 | 3607 | 1803.5 | 88.23 | 44.1 | New functions for the matrix metalloproteinases in cancer progression. | Mikala Egeblad, Zena Werb | Nat. Rev. Cancer | 2002 | 11990853 | No |
| 692 | 1803 | 1803.0 | 44.68 | 44.7 | NOX enzymes and the biology of reactive oxygen. | J David Lambeth | Nat. Rev. Immunol. | 2004 | 15039755 | No |
| 693 | 3597 | 1798.5 | 0.0 | 0.0 | Screening lambdagt recombinant clones by hybridization to single plaques in situ. | W D Benton, R W Davis | Science | 1977 | 322279 | Yes |
| 694 | 3593 | 1796.5 | 126.06 | 63.0 | Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9167458 | Yes |
| 695 | 1796 | 1796.0 | 61.76 | 61.8 | Dominant forces in protein folding. | K A Dill | Biochemistry | 1990 | 2207096 | No |
| 696 | 1794 | 1794.0 | 0.0 | 0.0 | A simple technique for demonstrating centromeric heterochromatin. | A T Sumner | Exp. Cell Res. | 1972 | 4117921 | Yes |
| 697 | 3583 | 1791.5 | 0.0 | 0.0 | A modified uronic acid carbazole reaction. | T BITTER, H M MUIR | Anal. Biochem. | 1962 | 13971270 | Yes |
| 698 | 5373 | 1791.0 | 140.9 | 47.0 | The biology of VEGF and its receptors. | Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter | Nat. Med. | 2003 | 12778165 | No |
| 699 | 5369 | 1789.7 | 404.3 | 134.8 | Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. | P J Van Soest, J B Robertson, B A Lewis | J. Dairy Sci. | 1991 | 1660498 | No |
| 700 | 3579 | 1789.5 | 174.96 | 87.5 | A feature-integration theory of attention. | A M Treisman, G Gelade | Cogn Psychol | 1980 | 7351125 | Yes |
| 701 | 1786 | 1786.0 | 95.3 | 95.3 | Effective physician-patient communication and health outcomes: a review. | M A Stewart | CMAJ | 1995 | 7728691 | Yes |
| 702 | 3565 | 1782.5 | 99.75 | 49.9 | Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. | Weizhong Li, Adam Godzik | Bioinformatics | 2006 | 16731699 | Yes |
| 703 | 1777 | 1777.0 | 74.28 | 74.3 | Working memory. | A Baddeley | Science | 1992 | 1736359 | No |
| 704 | 1773 | 1773.0 | 64.23 | 64.2 | Scaffolds in tissue engineering bone and cartilage. | D W Hutmacher | Biomaterials | 2000 | 11071603 | Yes |
| 705 | 3545 | 1772.5 | 154.56 | 77.3 | Random-effects models for longitudinal data. | N M Laird, J H Ware | Biometrics | 1982 | 7168798 | Yes |
| 706 | 1770 | 1770.0 | 46.6 | 46.6 | Chemokines and leukocyte traffic. | M Baggiolini | Nature | 1998 | 9560152 | No |
| 707 | 1770 | 1770.0 | 62.72 | 62.7 | RELION: implementation of a Bayesian approach to cryo-EM structure determination. | Sjors H W Scheres | J. Struct. Biol. | 2012 | 23000701 | Yes |
| 708 | 1762 | 1762.0 | 47.5 | 47.5 | Calcium signaling. | David E Clapham | Cell | 2007 | 18083096 | No |
| 709 | 1761 | 1761.0 | 49.37 | 49.4 | SV40-transformed simian cells support the replication of early SV40 mutants. | Y Gluzman | Cell | 1981 | 6260373 | Yes |
| 710 | 1759 | 1759.0 | 45.64 | 45.6 | Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. | T Hunter | Cell | 1995 | 7834742 | No |
| 711 | 1754 | 1754.0 | 38.19 | 38.2 | NK cell recognition. | Lewis L Lanier | Annu. Rev. Immunol. | 2005 | 15771571 | No |
| 712 | 1751 | 1751.0 | 54.25 | 54.2 | Immunological and inflammatory functions of the interleukin-1 family. | Charles A Dinarello | Annu. Rev. Immunol. | 2009 | 19302047 | No |
| 713 | 3500 | 1750.0 | 181.19 | 90.6 | A simple, rapid, and sensitive DNA assay procedure. | C Labarca, K Paigen | Anal. Biochem. | 1980 | 6158890 | Yes |
| 714 | 3498 | 1749.0 | 0.0 | 0.0 | A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. | S REITMAN, S FRANKEL | Am. J. Clin. Pathol. | 1957 | 13458125 | Yes |
| 715 | 1748 | 1748.0 | 87.81 | 87.8 | Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. | H W Steinbusch | Neuroscience | 1981 | 7017455 | Yes |
| 716 | 1747 | 1747.0 | 40.61 | 40.6 | Telomere measurement by quantitative PCR. | Richard M Cawthon | Nucleic Acids Res. | 2002 | 12000852 | Yes |
| 717 | 1747 | 1747.0 | 50.56 | 50.6 | Molecular basis of bacterial outer membrane permeability revisited. | Hiroshi Nikaido | Microbiol. Mol. Biol. Rev. | 2003 | 14665678 | No |
| 718 | 1747 | 1747.0 | 41.14 | 41.1 | Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. | Shimon Sakaguchi | Nat. Immunol. | 2005 | 15785760 | No |
| 719 | 1745 | 1745.0 | 0.0 | 0.0 | The biology of oxygen radicals. | I Fridovich | Science | 1978 | 210504 | Yes |
| 720 | 1745 | 1745.0 | 77.48 | 77.5 | Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. | B Samuelsson | Science | 1983 | 6301011 | Yes |
| 721 | 3486 | 1743.0 | 0.0 | 0.0 | A method for determining the sedimentation behavior of enzymes: application to protein mixtures. | R G MARTIN, B N AMES | J. Biol. Chem. | 1961 | 13767412 | Yes |
| 722 | 3485 | 1742.5 | 120.18 | 60.1 | Neural mechanisms of selective visual attention. | R Desimone, J Duncan | Annu. Rev. Neurosci. | 1995 | 7605061 | No |
| 723 | 3485 | 1742.5 | 109.55 | 54.8 | Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. | Marie-Christine Daniel, Didier Astruc | Chem. Rev. | 2004 | 14719978 | No |
| 724 | 6966 | 1741.5 | 232.45 | 58.1 | GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. | Berk Hess, Carsten Kutzner, David van der Spoel, Erik Lindahl | J Chem Theory Comput | 2008 | 26620784 | Yes |
| 725 | 5223 | 1741.0 | 181.71 | 60.6 | Bacterial biofilms: a common cause of persistent infections. | J W Costerton, P S Stewart, E P Greenberg | Science | 1999 | 10334980 | No |
| 726 | 1740 | 1740.0 | 0.0 | 0.0 | Elastic properties of lipid bilayers: theory and possible experiments. | W Helfrich | Z Naturforsch C | 1973 | 4273690 | Yes |
| 727 | 1740 | 1740.0 | 64.37 | 64.4 | Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. | H G Gratzner | Science | 1982 | 7123245 | Yes |
| 728 | 1738 | 1738.0 | 35.75 | 35.8 | Targeting RAS signalling pathways in cancer therapy. | Julian Downward | Nat. Rev. Cancer | 2003 | 12509763 | No |
| 729 | 3475 | 1737.5 | 139.63 | 69.8 | Complex network measures of brain connectivity: uses and interpretations. | Mikail Rubinov, Olaf Sporns | Neuroimage | 2010 | 19819337 | Yes |
| 730 | 1737 | 1737.0 | 35.86 | 35.9 | Histone acetylation in chromatin structure and transcription. | M Grunstein | Nature | 1997 | 9311776 | No |
| 731 | 1737 | 1737.0 | 66.12 | 66.1 | Accelerated Profile HMM Searches. | Sean R Eddy | PLoS Comput. Biol. | 2011 | 22039361 | Yes |
| 732 | 1736 | 1736.0 | 61.57 | 61.6 | Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. | J Kyhse-Andersen | J. Biochem. Biophys. Methods | 1984 | 6530509 | Yes |
| 733 | 3472 | 1736.0 | 105.55 | 52.8 | Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. | E Lander, L Kruglyak | Nat. Genet. | 1995 | 7581446 | Yes |
| 734 | 5206 | 1735.3 | 158.12 | 52.7 | RNA-Seq: a revolutionary tool for transcriptomics. | Zhong Wang, Mark Gerstein, Michael Snyder | Nat. Rev. Genet. | 2009 | 19015660 | No |
| 735 | 1732 | 1732.0 | 72.24 | 72.2 | Reactive oxygen species and the central nervous system. | B Halliwell | J. Neurochem. | 1992 | 1402908 | No |
| 736 | 3464 | 1732.0 | 89.58 | 44.8 | Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. | F Sallusto, A Lanzavecchia | J. Exp. Med. | 1994 | 8145033 | Yes |
| 737 | 1731 | 1731.0 | 0.0 | 0.0 | Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. | P Cuatrecasas | J. Biol. Chem. | 1970 | 5432796 | Yes |
| 738 | 1730 | 1730.0 | 0.0 | 0.0 | Isolation by Distance. | S Wright | Genetics | 1943 | 17247074 | Yes |
| 739 | 1725 | 1725.0 | 54.15 | 54.1 | Dietary pattern analysis: a new direction in nutritional epidemiology. | Frank B Hu | Curr. Opin. Lipidol. | 2002 | 11790957 | No |
| 740 | 1724 | 1724.0 | 81.49 | 81.5 | Glutamate, nitric oxide and cell-cell signalling in the nervous system. | J Garthwaite | Trends Neurosci. | 1991 | 1708538 | No |
| 741 | 1724 | 1724.0 | 59.91 | 59.9 | Physiology and neurobiology of stress and adaptation: central role of the brain. | Bruce S McEwen | Physiol. Rev. | 2007 | 17615391 | No |
| 742 | 3442 | 1721.0 | 100.4 | 50.2 | A global optimisation method for robust affine registration of brain images. | M Jenkinson, S Smith | Med Image Anal | 2001 | 11516708 | Yes |
| 743 | 1719 | 1719.0 | 45.53 | 45.5 | The regulation of AP-1 activity by mitogen-activated protein kinases. | M Karin | J. Biol. Chem. | 1995 | 7622446 | No |
| 744 | 1719 | 1719.0 | 48.66 | 48.7 | A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. | Pascal Fries | Trends Cogn. Sci. (Regul. Ed.) | 2005 | 16150631 | No |
| 745 | 1718 | 1718.0 | 62.59 | 62.6 | Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. | P Correa | Cancer Res. | 1992 | 1458460 | No |
| 746 | 1718 | 1718.0 | 73.35 | 73.3 | Role of oxidative stress in development of complications in diabetes. | J W Baynes | Diabetes | 1991 | 2010041 | No |
| 747 | 1718 | 1718.0 | 50.5 | 50.5 | Biology of natural killer cells. | G Trinchieri | Adv. Immunol. | 1989 | 2683611 | No |
| 748 | 1717 | 1717.0 | 0.0 | 0.0 | Muscle structure and theories of contraction. | A F HUXLEY | Prog Biophys Biophys Chem | 1957 | 13485191 | Yes |
| 749 | 3433 | 1716.5 | 100.19 | 50.1 | Signal transduction by receptors with tyrosine kinase activity. | A Ullrich, J Schlessinger | Cell | 1990 | 2158859 | No |
| 750 | 3430 | 1715.0 | 89.06 | 44.5 | AKT/PKB signaling: navigating downstream. | Brendan D Manning, Lewis C Cantley | Cell | 2007 | 17604717 | No |
| 751 | 1712 | 1712.0 | 53.3 | 53.3 | A model for receptor-regulated calcium entry. | J W Putney | Cell Calcium | 1986 | 2420465 | No |
| 752 | 3424 | 1712.0 | 132.79 | 66.4 | Missing data: our view of the state of the art. | Joseph L Schafer, John W Graham | Psychol Methods | 2002 | 12090408 | Yes |
| 753 | 3424 | 1712.0 | 85.17 | 42.6 | Mass spectrometry-based proteomics. | Ruedi Aebersold, Matthias Mann | Nature | 2003 | 12634793 | No |
| 754 | 3423 | 1711.5 | 0.0 | 0.0 | Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. | R A Laskey, A D Mills | Eur. J. Biochem. | 1975 | 1175627 | Yes |
| 755 | 1711 | 1711.0 | 0.0 | 0.0 | SEDIMENTATION STUDIES OF THE SIZE AND SHAPE OF DNA. | F W STUDIER | J. Mol. Biol. | 1965 | 14290352 | Yes |
| 756 | 3421 | 1710.5 | 197.75 | 98.9 | Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. | N S Jacobson, P Truax | J Consult Clin Psychol | 1991 | 2002127 | Yes |
| 757 | 3421 | 1710.5 | 93.14 | 46.6 | The Bcl-2 protein family: arbiters of cell survival. | J M Adams, S Cory | Science | 1998 | 9735050 | No |
| 758 | 3419 | 1709.5 | 99.72 | 49.9 | Reactive oxygen species: metabolism, oxidative stress, and signal transduction. | Klaus Apel, Heribert Hirt | Annu Rev Plant Biol | 2004 | 15377225 | No |
| 759 | 3413 | 1706.5 | 138.83 | 69.4 | Accurate and simple analytic representation of the electron-gas correlation energy. | Perdew, Wang | Phys. Rev., B Condens. Matter | 1992 | 10001404 | Yes |
| 760 | 3408 | 1704.0 | 185.56 | 92.8 | The qualitative content analysis process. | Satu Elo, Helvi Kyngäs | J Adv Nurs | 2008 | 18352969 | Yes |
| 761 | 1703 | 1703.0 | 43.84 | 43.8 | Complement. First of two parts. | M J Walport | N. Engl. J. Med. | 2001 | 11287977 | No |
| 762 | 1699 | 1699.0 | 65.08 | 65.1 | Biodiesel from microalgae. | Yusuf Chisti | Biotechnol. Adv. | 2007 | 17350212 | No |
| 763 | 3390 | 1695.0 | 0.0 | 0.0 | The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. | H P Misra, I Fridovich | J. Biol. Chem. | 1972 | 4623845 | Yes |
| 764 | 3390 | 1695.0 | 0.0 | 0.0 | The interpretation of protein structures: estimation of static accessibility. | B Lee, F M Richards | J. Mol. Biol. | 1971 | 5551392 | Yes |
| 765 | 3389 | 1694.5 | 95.39 | 47.7 | Protein misfolding, functional amyloid, and human disease. | Fabrizio Chiti, Christopher M Dobson | Annu. Rev. Biochem. | 2006 | 16756495 | No |
| 766 | 1693 | 1693.0 | 68.17 | 68.2 | The unbiased estimation of number and sizes of arbitrary particles using the disector. | D C Sterio | J Microsc | 1984 | 6737468 | Yes |
| 767 | 1693 | 1693.0 | 45.19 | 45.2 | A decade of molecular biology of retinoic acid receptors. | P Chambon | FASEB J. | 1996 | 8801176 | No |
| 768 | 1692 | 1692.0 | 0.0 | 0.0 | Catheter replacement of the needle in percutaneous arteriography; a new technique. | S I SELDINGER | Acta radiol | 1953 | 13057644 | Yes |
| 769 | 1692 | 1692.0 | 48.7 | 48.7 | Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. | Edward V Loftus | Gastroenterology | 2004 | 15168363 | Yes |
| 770 | 3379 | 1689.5 | 109.64 | 54.8 | Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. | C W Elston, I O Ellis | Histopathology | 1991 | 1757079 | Yes |
| 771 | 1689 | 1689.0 | 36.11 | 36.1 | Shelterin: the protein complex that shapes and safeguards human telomeres. | Titia de Lange | Genes Dev. | 2005 | 16166375 | No |
| 772 | 1689 | 1689.0 | 83.67 | 83.7 | The Danish Civil Registration System. | Carsten Bøcker Pedersen | Scand J Public Health | 2011 | 21775345 | Yes |
| 773 | 10129 | 1688.2 | 467.18 | 77.9 | Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. | Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G Conde | J Biomed Inform | 2009 | 18929686 | Yes |
| 774 | 1687 | 1687.0 | 65.9 | 65.9 | A two process model of sleep regulation. | A A Borbély | Hum Neurobiol | 1982 | 7185792 | Yes |
| 775 | 5049 | 1683.0 | 108.68 | 36.2 | Control of regulatory T cell development by the transcription factor Foxp3. | Shohei Hori, Takashi Nomura, Shimon Sakaguchi | Science | 2003 | 12522256 | Yes |
| 776 | 1680 | 1680.0 | 0.0 | 0.0 | The membrane actions of anesthetics and tranquilizers. | P Seeman | Pharmacol. Rev. | 1972 | 4565956 | No |
| 777 | 1679 | 1679.0 | 47.88 | 47.9 | Social controls on cell survival and cell death. | M C Raff | Nature | 1992 | 1557121 | No |
| 778 | 1679 | 1679.0 | 53.99 | 54.0 | The heme oxygenase system: a regulator of second messenger gases. | M D Maines | Annu. Rev. Pharmacol. Toxicol. | 1997 | 9131263 | No |
| 779 | 10071 | 1678.5 | 418.37 | 69.7 | Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. | Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell Parkin | Int. J. Cancer | 2010 | 21351269 | Yes |
| 780 | 3353 | 1676.5 | 110.56 | 55.3 | Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. | Michael D Fox, Marcus E Raichle | Nat. Rev. Neurosci. | 2007 | 17704812 | No |
| 781 | 1676 | 1676.0 | 44.56 | 44.6 | Modularity and community structure in networks. | M E J Newman | Proc. Natl. Acad. Sci. U.S.A. | 2006 | 16723398 | Yes |
| 782 | 1674 | 1674.0 | 57.02 | 57.0 | Estimating causal effects from large data sets using propensity scores. | D B Rubin | Ann. Intern. Med. | 1997 | 9382394 | No |
| 783 | 1670 | 1670.0 | 59.79 | 59.8 | Molecular diversity of glutamate receptors and implications for brain function. | S Nakanishi | Science | 1992 | 1329206 | No |
| 784 | 3340 | 1670.0 | 0.0 | 0.0 | Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. | J D WATSON, F H CRICK | Nature | 1953 | 13054692 | Yes |
| 785 | 3337 | 1668.5 | 0.0 | 0.0 | The Social Readjustment Rating Scale. | T H Holmes, R H Rahe | J Psychosom Res | 1967 | 6059863 | Yes |
| 786 | 1668 | 1668.0 | 69.19 | 69.2 | Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. | W A Craig | Clin. Infect. Dis. | 1998 | 9455502 | No |
| 787 | 3335 | 1667.5 | 109.23 | 54.6 | Pattern recognition receptors and inflammation. | Osamu Takeuchi, Shizuo Akira | Cell | 2010 | 20303872 | No |
| 788 | 3333 | 1666.5 | 0.0 | 0.0 | Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. | T V Bliss, T Lomo | J. Physiol. (Lond.) | 1973 | 4727084 | Yes |
| 789 | 6665 | 1666.2 | 241.95 | 60.5 | Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. | Qiong Wang, George M Garrity, James M Tiedje, James R Cole | Appl. Environ. Microbiol. | 2007 | 17586664 | Yes |
| 790 | 1666 | 1666.0 | 85.76 | 85.8 | FreeSurfer. | Bruce Fischl | Neuroimage | 2012 | 22248573 | No |
| 791 | 1665 | 1665.0 | 74.49 | 74.5 | What is value in health care? | Michael E Porter | N. Engl. J. Med. | 2010 | 21142528 | Yes |
| 792 | 3326 | 1663.0 | 106.18 | 53.1 | Organization and expression of eucaryotic split genes coding for proteins. | R Breathnach, P Chambon | Annu. Rev. Biochem. | 1981 | 6791577 | No |
| 793 | 3318 | 1659.0 | 95.48 | 47.7 | Nonparametric permutation tests for functional neuroimaging: a primer with examples. | Thomas E Nichols, Andrew P Holmes | Hum Brain Mapp | 2002 | 11747097 | Yes |
| 794 | 1657 | 1657.0 | 53.49 | 53.5 | Descending control of pain. | Mark J Millan | Prog. Neurobiol. | 2002 | 12034378 | No |
| 795 | 3313 | 1656.5 | 101.55 | 50.8 | Acute-phase proteins and other systemic responses to inflammation. | C Gabay, I Kushner | N. Engl. J. Med. | 1999 | 9971870 | No |
| 796 | 1656 | 1656.0 | 46.33 | 46.3 | Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. | Jane Glazebrook | Annu Rev Phytopathol | 2005 | 16078883 | No |
| 797 | 1655 | 1655.0 | 40.54 | 40.5 | Cisplatin: mode of cytotoxic action and molecular basis of resistance. | Zahid H Siddik | Oncogene | 2003 | 14576837 | No |
| 798 | 1655 | 1655.0 | 58.68 | 58.7 | adegenet: a R package for the multivariate analysis of genetic markers. | Thibaut Jombart | Bioinformatics | 2008 | 18397895 | Yes |
| 799 | 1653 | 1653.0 | 72.18 | 72.2 | Secretory products of macrophages. | C F Nathan | J. Clin. Invest. | 1987 | 3543052 | No |
| 800 | 1653 | 1653.0 | 0.0 | 0.0 | The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. | S BOYDEN | J. Exp. Med. | 1962 | 13872176 | Yes |
| 801 | 3305 | 1652.5 | 101.09 | 50.5 | The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. | Karen Bedard, Karl-Heinz Krause | Physiol. Rev. | 2007 | 17237347 | No |
| 802 | 3303 | 1651.5 | 72.37 | 36.2 | Network biology: understanding the cell's functional organization. | Albert-László Barabási, Zoltán N Oltvai | Nat. Rev. Genet. | 2004 | 14735121 | No |
| 803 | 1651 | 1651.0 | 0.0 | 0.0 | The Michigan alcoholism screening test: the quest for a new diagnostic instrument. | M L Selzer | Am J Psychiatry | 1971 | 5565851 | Yes |
| 804 | 1651 | 1651.0 | 47.77 | 47.8 | Negative refraction makes a perfect lens | Pendry | Phys. Rev. Lett. | 2000 | 11041972 | Yes |
| 805 | 1651 | 1651.0 | 54.96 | 55.0 | The episodic buffer: a new component of working memory? | Baddeley | Trends Cogn. Sci. (Regul. Ed.) | 2000 | 11058819 | Yes |
| 806 | 3297 | 1648.5 | 75.95 | 38.0 | Mammalian MAP kinase signalling cascades. | L Chang, M Karin | Nature | 2001 | 11242034 | No |
| 807 | 1646 | 1646.0 | 44.43 | 44.4 | Rab GTPases as coordinators of vesicle traffic. | Harald Stenmark | Nat. Rev. Mol. Cell Biol. | 2009 | 19603039 | No |
| 808 | 1645 | 1645.0 | 46.06 | 46.1 | Specification of cerebral cortical areas. | P Rakic | Science | 1988 | 3291116 | No |
| 809 | 1644 | 1644.0 | 80.53 | 80.5 | The Resonating Valence Bond State in La2CuO4 and Superconductivity. | P W Anderson | Science | 1987 | 17818979 | Yes |
| 810 | 3286 | 1643.0 | 78.32 | 39.2 | Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. | M Gossen, H Bujard | Proc. Natl. Acad. Sci. U.S.A. | 1992 | 1319065 | Yes |
| 811 | 1640 | 1640.0 | 40.27 | 40.3 | XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. | D E McRee | J. Struct. Biol. | 1999 | 10222271 | Yes |
| 812 | 1639 | 1639.0 | 37.47 | 37.5 | CpG motifs in bacterial DNA and their immune effects. | Arthur M Krieg | Annu. Rev. Immunol. | 2002 | 11861616 | No |
| 813 | 4915 | 1638.3 | 149.08 | 49.7 | GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. | R A Jefferson, T A Kavanagh, M W Bevan | EMBO J. | 1987 | 3327686 | Yes |
| 814 | 4915 | 1638.3 | 132.2 | 44.1 | MOLMOL: a program for display and analysis of macromolecular structures. | R Koradi, M Billeter, K Wüthrich | J Mol Graph | 1996 | 8744573 | Yes |
| 815 | 3276 | 1638.0 | 0.0 | 0.0 | Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. | A C Chang, S N Cohen | J. Bacteriol. | 1978 | 149110 | Yes |
| 816 | 1638 | 1638.0 | 0.0 | 0.0 | Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. | F F Jöbsis | Science | 1977 | 929199 | Yes |
| 817 | 1636 | 1636.0 | 45.31 | 45.3 | Inferring the historical patterns of biological evolution. | M Pagel | Nature | 1999 | 10553904 | Yes |
| 818 | 4906 | 1635.3 | 238.41 | 79.5 | Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. | G Muyzer, E C de Waal, A G Uitterlinden | Appl. Environ. Microbiol. | 1993 | 7683183 | Yes |
| 819 | 1635 | 1635.0 | 55.33 | 55.3 | A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. | P Chomczynski | BioTechniques | 1993 | 7692896 | Yes |
| 820 | 1635 | 1635.0 | 0.0 | 0.0 | A GENERALIZED WILCOXON TEST FOR COMPARING ARBITRARILY SINGLY-CENSORED SAMPLES. | E A GEHAN | Biometrika | 1965 | 14341275 | Yes |
| 821 | 1631 | 1631.0 | 47.08 | 47.1 | RGD and other recognition sequences for integrins. | E Ruoslahti | Annu. Rev. Cell Dev. Biol. | 1996 | 8970741 | No |
| 822 | 4886 | 1628.7 | 181.23 | 60.4 | Arlequin (version 3.0): an integrated software package for population genetics data analysis. | Laurent Excoffier, Guillaume Laval, Stefan Schneider | Evol. Bioinform. Online | 2007 | 19325852 | Yes |
| 823 | 1628 | 1628.0 | 77.46 | 77.5 | International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. | C Herrmann | J Psychosom Res | 1997 | 9055211 | No |
| 824 | 9767 | 1627.8 | 244.36 | 40.7 | NMRPipe: a multidimensional spectral processing system based on UNIX pipes. | F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A Bax | J. Biomol. NMR | 1995 | 8520220 | Yes |
| 825 | 3251 | 1625.5 | 0.0 | 0.0 | A diagnostic interview: the schedule for affective disorders and schizophrenia. | J Endicott, R L Spitzer | Arch. Gen. Psychiatry | 1978 | 678037 | Yes |
| 826 | 3249 | 1624.5 | 89.81 | 44.9 | Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. | B A Reynolds, S Weiss | Science | 1992 | 1553558 | Yes |
| 827 | 6494 | 1623.5 | 282.12 | 70.5 | A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. | Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge Krieg | J Chem Phys | 2010 | 20423165 | Yes |
| 828 | 1623 | 1623.0 | 47.05 | 47.0 | Protein kinase C and lipid signaling for sustained cellular responses. | Y Nishizuka | FASEB J. | 1995 | 7737456 | No |
| 829 | 3244 | 1622.0 | 140.98 | 70.5 | The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. | S H Downs, N Black | J Epidemiol Community Health | 1998 | 9764259 | Yes |
| 830 | 3242 | 1621.0 | 93.88 | 46.9 | Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. | Hashem B El-Serag, K Lenhard Rudolph | Gastroenterology | 2007 | 17570226 | No |
| 831 | 1620 | 1620.0 | 0.0 | 0.0 | Diffusion-in-gel methods for immunological analysis. | O OUCHTERLONY | Prog Allergy | 1958 | 13578996 | Yes |
| 832 | 1620 | 1620.0 | 54.78 | 54.8 | Pancreatic cancer. | Manuel Hidalgo | N. Engl. J. Med. | 2010 | 20427809 | No |
| 833 | 4857 | 1619.0 | 128.57 | 42.9 | A new statistical method for haplotype reconstruction from population data. | M Stephens, N J Smith, P Donnelly | Am. J. Hum. Genet. | 2001 | 11254454 | Yes |
| 834 | 6471 | 1617.8 | 161.7 | 40.4 | Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. | A Krogh, B Larsson, G von Heijne, E L Sonnhammer | J. Mol. Biol. | 2001 | 11152613 | Yes |
| 835 | 4843 | 1614.3 | 268.76 | 89.6 | Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. | J L Cox, J M Holden, R Sagovsky | Br J Psychiatry | 1987 | 3651732 | Yes |
| 836 | 3228 | 1614.0 | 108.26 | 54.1 | A simple and very efficient method for generating cDNA libraries. | U Gubler, B J Hoffman | Gene | 1983 | 6198242 | Yes |
| 837 | 9682 | 1613.7 | 323.34 | 53.9 | A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. | A S Levey, J P Bosch, J B Lewis, T Greene, N Rogers, D Roth | Ann. Intern. Med. | 1999 | 10075613 | Yes |
| 838 | 1613 | 1613.0 | 31.46 | 31.5 | ATM and related protein kinases: safeguarding genome integrity. | Yosef Shiloh | Nat. Rev. Cancer | 2003 | 12612651 | No |
| 839 | 1611 | 1611.0 | 83.49 | 83.5 | A systematic method for clinical description and classification of personality variants. A proposal. | C R Cloninger | Arch. Gen. Psychiatry | 1987 | 3579504 | Yes |
| 840 | 1611 | 1611.0 | 0.0 | 0.0 | Stereochemistry of cooperative effects in haemoglobin. | M F Perutz | Nature | 1970 | 5528785 | Yes |
| 841 | 1611 | 1611.0 | 0.0 | 0.0 | Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. | G BERTANI | J. Bacteriol. | 1951 | 14888646 | Yes |
| 842 | 12885 | 1610.6 | 527.85 | 66.0 | The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. | D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C Siebert | N. Engl. J. Med. | 1993 | 8366922 | Yes |
| 843 | 3217 | 1608.5 | 97.55 | 48.8 | Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. | M Nei, T Gojobori | Mol. Biol. Evol. | 1986 | 3444411 | Yes |
| 844 | 4823 | 1607.7 | 0.0 | 0.0 | ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL. | J MONOD, J WYMAN, J P CHANGEUX | J. Mol. Biol. | 1965 | 14343300 | Yes |
| 845 | 1607 | 1607.0 | 45.39 | 45.4 | The inflammatory reflex. | Kevin J Tracey | Nature | 2002 | 12490958 | No |
| 846 | 4820 | 1606.7 | 176.61 | 58.9 | Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. | C E Murry, R B Jennings, K A Reimer | Circulation | 1986 | 3769170 | Yes |
| 847 | 3212 | 1606.0 | 92.75 | 46.4 | Myeloid-derived suppressor cells as regulators of the immune system. | Dmitry I Gabrilovich, Srinivas Nagaraj | Nat. Rev. Immunol. | 2009 | 19197294 | No |
| 848 | 1604 | 1604.0 | 57.41 | 57.4 | Hybrid porous solids: past, present, future. | Gérard Férey | Chem Soc Rev | 2008 | 18197340 | Yes |
| 849 | 1602 | 1602.0 | 59.73 | 59.7 | Calbindin D-28k and parvalbumin in the rat nervous system. | M R Celio | Neuroscience | 1990 | 2199841 | Yes |
| 850 | 1601 | 1601.0 | 82.74 | 82.7 | Role of Streptococcus mutans in human dental decay. | W J Loesche | Microbiol. Rev. | 1986 | 3540569 | No |
| 851 | 1601 | 1601.0 | 68.5 | 68.5 | Spinal and supraspinal factors in human muscle fatigue. | S C Gandevia | Physiol. Rev. | 2001 | 11581501 | No |
| 852 | 3201 | 1600.5 | 98.01 | 49.0 | Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. | M Matsuda, R A DeFronzo | Diabetes Care | 1999 | 10480510 | Yes |
| 853 | 1600 | 1600.0 | 37.55 | 37.5 | Molecular bases for circadian clocks. | J C Dunlap | Cell | 1999 | 9988221 | No |
| 854 | 1599 | 1599.0 | 49.33 | 49.3 | Working memory: looking back and looking forward. | Alan Baddeley | Nat. Rev. Neurosci. | 2003 | 14523382 | No |
| 855 | 9589 | 1598.2 | 2309.53 | 384.9 | Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. | Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal | CA Cancer J Clin | 2018 | 30207593 | Yes |
| 856 | 4794 | 1598.0 | 186.57 | 62.2 | Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. | L Excoffier, P E Smouse, J M Quattro | Genetics | 1992 | 1644282 | Yes |
| 857 | 1597 | 1597.0 | 0.0 | 0.0 | Analysis of bacteriophage T7 early RNAs and proteins on slab gels. | F W Studier | J. Mol. Biol. | 1973 | 4760132 | Yes |
| 858 | 3194 | 1597.0 | 0.0 | 0.0 | Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. | J V Durnin, J Womersley | Br. J. Nutr. | 1974 | 4843734 | Yes |
| 859 | 1597 | 1597.0 | 53.55 | 53.5 | Efficient methods to compute genomic predictions. | P M VanRaden | J. Dairy Sci. | 2008 | 18946147 | Yes |
| 860 | 1595 | 1595.0 | 39.33 | 39.3 | Nitric oxide and the immune response. | C Bogdan | Nat. Immunol. | 2001 | 11577346 | No |
| 861 | 3187 | 1593.5 | 101.06 | 50.5 | Application of phylogenetic networks in evolutionary studies. | Daniel H Huson, David Bryant | Mol. Biol. Evol. | 2006 | 16221896 | Yes |
| 862 | 3180 | 1590.0 | 125.22 | 62.6 | A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. | G J Bennett, Y K Xie | Pain | 1988 | 2837713 | Yes |
| 863 | 1590 | 1590.0 | 0.0 | 0.0 | Transplacental carcinogenesis by stilbestrol. | J Folkman | N. Engl. J. Med. | 1971 | 5556579 | Yes |
| 864 | 3180 | 1590.0 | 98.64 | 49.3 | Function and activation of NF-kappa B in the immune system. | P A Baeuerle, T Henkel | Annu. Rev. Immunol. | 1994 | 8011280 | No |
| 865 | 3175 | 1587.5 | 141.34 | 70.7 | The attention system of the human brain. | M I Posner, S E Petersen | Annu. Rev. Neurosci. | 1990 | 2183676 | No |
| 866 | 4760 | 1586.7 | 108.79 | 36.3 | EMBOSS: the European Molecular Biology Open Software Suite. | P Rice, I Longden, A Bleasby | Trends Genet. | 2000 | 10827456 | Yes |
| 867 | 3173 | 1586.5 | 128.69 | 64.3 | Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. | R M Ryan, E L Deci | Am Psychol | 2000 | 11392867 | Yes |
| 868 | 3171 | 1585.5 | 88.04 | 44.0 | The acute respiratory distress syndrome. | L B Ware, M A Matthay | N. Engl. J. Med. | 2000 | 10793167 | No |
| 869 | 3170 | 1585.0 | 113.44 | 56.7 | Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. | J S Beckman, W H Koppenol | Am. J. Physiol. | 1996 | 8944624 | No |
| 870 | 1582 | 1582.0 | 31.19 | 31.2 | Mechanisms of alternative pre-messenger RNA splicing. | Douglas L Black | Annu. Rev. Biochem. | 2003 | 12626338 | No |
| 871 | 4745 | 1581.7 | 178.26 | 59.4 | Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. | C Lord, M Rutter, A Le Couteur | J Autism Dev Disord | 1994 | 7814313 | Yes |
| 872 | 3163 | 1581.5 | 0.0 | 0.0 | High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. | M N Berry, D S Friend | J. Cell Biol. | 1969 | 4900611 | Yes |
| 873 | 3162 | 1581.0 | 194.89 | 97.4 | Stress, social support, and the buffering hypothesis. | S Cohen, T A Wills | Psychol Bull | 1985 | 3901065 | No |
| 874 | 3160 | 1580.0 | 82.15 | 41.1 | Base-calling of automated sequencer traces using phred. II. Error probabilities. | B Ewing, P Green | Genome Res. | 1998 | 9521922 | Yes |
| 875 | 3160 | 1580.0 | 69.67 | 34.8 | The Wnt signaling pathway in development and disease. | Catriona Y Logan, Roel Nusse | Annu. Rev. Cell Dev. Biol. | 2004 | 15473860 | No |
| 876 | 1579 | 1579.0 | 54.42 | 54.4 | Determination and analysis of urea and guanidine hydrochloride denaturation curves. | C N Pace | Meth. Enzymol. | 1986 | 3773761 | Yes |
| 877 | 1578 | 1578.0 | 34.01 | 34.0 | In situ hybridization: an improved whole-mount method for Xenopus embryos. | R M Harland | Methods Cell Biol. | 1991 | 1811161 | Yes |
| 878 | 1578 | 1578.0 | 45.08 | 45.1 | The mitogen-activated protein kinase signal transduction pathway. | R J Davis | J. Biol. Chem. | 1993 | 8325833 | No |
| 879 | 1578 | 1578.0 | 34.8 | 34.8 | Mechanisms of type-I- and type-II-interferon-mediated signalling. | Leonidas C Platanias | Nat. Rev. Immunol. | 2005 | 15864272 | No |
| 880 | 4733 | 1577.7 | 219.17 | 73.1 | Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. | Allison Tong, Peter Sainsbury, Jonathan Craig | Int J Qual Health Care | 2007 | 17872937 | Yes |
| 881 | 1577 | 1577.0 | 53.36 | 53.4 | Superoxide radical and superoxide dismutases. | I Fridovich | Annu. Rev. Biochem. | 1995 | 7574505 | No |
| 882 | 1577 | 1577.0 | 59.75 | 59.8 | Fetal origins of coronary heart disease. | D J Barker | BMJ | 1995 | 7613432 | No |
| 883 | 1577 | 1577.0 | 38.04 | 38.0 | Mechanisms of intracellular protein transport. | J E Rothman | Nature | 1994 | 7969419 | No |
| 884 | 1575 | 1575.0 | 34.77 | 34.8 | Systems biology: a brief overview. | Hiroaki Kitano | Science | 2002 | 11872829 | No |
| 885 | 3149 | 1574.5 | 96.26 | 48.1 | Regulation of the mevalonate pathway. | J L Goldstein, M S Brown | Nature | 1990 | 1967820 | No |
| 886 | 1574 | 1574.0 | 36.38 | 36.4 | Protein modules and signalling networks. | T Pawson | Nature | 1995 | 7531822 | No |
| 887 | 1574 | 1574.0 | 69.89 | 69.9 | Qualitative research: standards, challenges, and guidelines. | K Malterud | Lancet | 2001 | 11513933 | Yes |
| 888 | 1573 | 1573.0 | 47.78 | 47.8 | Mechanisms and genes of cellular suicide. | H Steller | Science | 1995 | 7878463 | No |
| 889 | 1573 | 1573.0 | 39.91 | 39.9 | Defensins: antimicrobial peptides of innate immunity. | Tomas Ganz | Nat. Rev. Immunol. | 2003 | 12949495 | No |
| 890 | 1573 | 1573.0 | 36.26 | 36.3 | The complex language of chromatin regulation during transcription. | Shelley L Berger | Nature | 2007 | 17522673 | No |
| 891 | 3144 | 1572.0 | 0.0 | 0.0 | The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. | J A Spudich, S Watt | J. Biol. Chem. | 1971 | 4254541 | Yes |
| 892 | 1569 | 1569.0 | 66.43 | 66.4 | A classification of glycosyl hydrolases based on amino acid sequence similarities. | B Henrissat | Biochem. J. | 1991 | 1747104 | Yes |
| 893 | 1569 | 1569.0 | 45.83 | 45.8 | The structure and regulation of protein phosphatases. | P Cohen | Annu. Rev. Biochem. | 1989 | 2549856 | No |
| 894 | 4704 | 1568.0 | 139.51 | 46.5 | Cortical surface-based analysis. I. Segmentation and surface reconstruction. | A M Dale, B Fischl, M I Sereno | Neuroimage | 1999 | 9931268 | Yes |
| 895 | 1567 | 1567.0 | 52.58 | 52.6 | Patterns of amino acids near signal-sequence cleavage sites. | G von Heijne | Eur. J. Biochem. | 1983 | 6852022 | Yes |
| 896 | 1567 | 1567.0 | 54.58 | 54.6 | Stress, adaptation, and disease. Allostasis and allostatic load. | B S McEwen | Ann. N. Y. Acad. Sci. | 1998 | 9629234 | No |
| 897 | 1567 | 1567.0 | 36.81 | 36.8 | The expanding role of mitochondria in apoptosis. | X Wang | Genes Dev. | 2001 | 11711427 | No |
| 898 | 3131 | 1565.5 | 0.0 | 0.0 | Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. | P J Fraker, J C Speck | Biochem. Biophys. Res. Commun. | 1978 | 637870 | Yes |
| 899 | 3126 | 1563.0 | 106.28 | 53.1 | A receptor-mediated pathway for cholesterol homeostasis. | M S Brown, J L Goldstein | Science | 1986 | 3513311 | No |
| 900 | 3125 | 1562.5 | 92.12 | 46.1 | Leptin and the regulation of body weight in mammals. | J M Friedman, J L Halaas | Nature | 1998 | 9796811 | No |
| 901 | 3125 | 1562.5 | 92.71 | 46.4 | The endophenotype concept in psychiatry: etymology and strategic intentions. | Irving I Gottesman, Todd D Gould | Am J Psychiatry | 2003 | 12668349 | No |
| 902 | 3124 | 1562.0 | 83.06 | 41.5 | The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. | A J Ridley, A Hall | Cell | 1992 | 1643657 | Yes |
| 903 | 1561 | 1561.0 | 46.03 | 46.0 | Dopamine, learning and motivation. | Roy A Wise | Nat. Rev. Neurosci. | 2004 | 15152198 | No |
| 904 | 3121 | 1560.5 | 69.01 | 34.5 | Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. | M Karin, Y Ben-Neriah | Annu. Rev. Immunol. | 2000 | 10837071 | No |
| 905 | 3111 | 1555.5 | 68.2 | 34.1 | Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. | Rudolf Jaenisch, Adrian Bird | Nat. Genet. | 2003 | 12610534 | No |
| 906 | 1555 | 1555.0 | 95.92 | 95.9 | Structural Model Evaluation and Modification: An Interval Estimation Approach. | J H Steiger | Multivariate Behav Res | 1990 | 26794479 | Yes |
| 907 | 3109 | 1554.5 | 93.72 | 46.9 | UniFrac: a new phylogenetic method for comparing microbial communities. | Catherine Lozupone, Rob Knight | Appl. Environ. Microbiol. | 2005 | 16332807 | Yes |
| 908 | 1554 | 1554.0 | 55.15 | 55.1 | Formation and Structure of Self-Assembled Monolayers. | Abraham Ulman | Chem. Rev. | 1996 | 11848802 | Yes |
| 909 | 3104 | 1552.0 | 109.51 | 54.8 | The number of people with glaucoma worldwide in 2010 and 2020. | H A Quigley, A T Broman | Br J Ophthalmol | 2006 | 16488940 | Yes |
| 910 | 1550 | 1550.0 | 35.38 | 35.4 | Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. | R J Kaufman | Genes Dev. | 1999 | 10346810 | No |
| 911 | 1549 | 1549.0 | 61.8 | 61.8 | Eye movements in reading and information processing: 20 years of research. | K Rayner | Psychol Bull | 1998 | 9849112 | No |
| 912 | 1549 | 1549.0 | 36.2 | 36.2 | Metastasis to bone: causes, consequences and therapeutic opportunities. | Gregory R Mundy | Nat. Rev. Cancer | 2002 | 12154351 | No |
| 913 | 1549 | 1549.0 | 41.57 | 41.6 | Pathways towards and away from Alzheimer's disease. | Mark P Mattson | Nature | 2004 | 15295589 | No |
| 914 | 3092 | 1546.0 | 67.21 | 33.6 | The fundamental role of epigenetic events in cancer. | Peter A Jones, Stephen B Baylin | Nat. Rev. Genet. | 2002 | 12042769 | No |
| 915 | 1545 | 1545.0 | 60.99 | 61.0 | An empirical correction for absorption anisotropy. | R H Blessing | Acta Crystallogr., A, Found. Crystallogr. | 1995 | 7702794 | Yes |
| 916 | 1545 | 1545.0 | 0.0 | 0.0 | A RATIONALE AND TEST FOR THE NUMBER OF FACTORS IN FACTOR ANALYSIS. | J L HORN | Psychometrika | 1965 | 14306381 | Yes |
| 917 | 1545 | 1545.0 | 0.0 | 0.0 | The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. | R R PORTER | Biochem. J. | 1959 | 14434282 | Yes |
| 918 | 1544 | 1544.0 | 0.0 | 0.0 | Efficient trace-labelling of proteins with iodine. | A S McFARLANE | Nature | 1958 | 13566175 | Yes |
| 919 | 3085 | 1542.5 | 182.72 | 91.4 | Stages and processes of self-change of smoking: toward an integrative model of change. | J O Prochaska, C C DiClemente | J Consult Clin Psychol | 1983 | 6863699 | Yes |
| 920 | 1542 | 1542.0 | 67.16 | 67.2 | Human error: models and management. | J Reason | BMJ | 2000 | 10720363 | Yes |
| 921 | 3083 | 1541.5 | 0.0 | 0.0 | Acetylornithinase of Escherichia coli: partial purification and some properties. | H J VOGEL, D M BONNER | J. Biol. Chem. | 1956 | 13278318 | Yes |
| 922 | 1541 | 1541.0 | 44.33 | 44.3 | Calcium signaling. | D E Clapham | Cell | 1995 | 7834745 | No |
| 923 | 1541 | 1541.0 | 48.97 | 49.0 | Hepatitis B virus infection. | W M Lee | N. Engl. J. Med. | 1997 | 9392700 | No |
| 924 | 3081 | 1540.5 | 81.23 | 40.6 | Brown adipose tissue: function and physiological significance. | Barbara Cannon, Jan Nedergaard | Physiol. Rev. | 2004 | 14715917 | No |
| 925 | 1540 | 1540.0 | 73.46 | 73.5 | Specific impairments of planning. | T Shallice | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | 1982 | 6125971 | Yes |
| 926 | 1540 | 1540.0 | 47.34 | 47.3 | Mechanisms of hepatic fibrogenesis. | Scott L Friedman | Gastroenterology | 2008 | 18471545 | No |
| 927 | 3077 | 1538.5 | 91.42 | 45.7 | Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. | P J Barnes, M Karin | N. Engl. J. Med. | 1997 | 9091804 | No |
| 928 | 1537 | 1537.0 | 0.0 | 0.0 | The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. | U E Loening | Biochem. J. | 1967 | 5339944 | Yes |
| 929 | 3074 | 1537.0 | 116.42 | 58.2 | SPSS and SAS procedures for estimating indirect effects in simple mediation models. | Kristopher J Preacher, Andrew F Hayes | Behav Res Methods Instrum Comput | 2004 | 15641418 | Yes |
| 930 | 1535 | 1535.0 | 30.31 | 30.3 | The regulation of E2F by pRB-family proteins. | N Dyson | Genes Dev. | 1998 | 9694791 | No |
| 931 | 1535 | 1535.0 | 0.0 | 0.0 | Notes on sugar determination. | M SMOGYI | J. Biol. Chem. | 1952 | 14938350 | Yes |
| 932 | 1534 | 1534.0 | 38.77 | 38.8 | The immunopathogenesis of sepsis. | Jonathan Cohen | Nature | 2002 | 12490963 | No |
| 933 | 1534 | 1534.0 | 69.67 | 69.7 | Epidemiology of viral hepatitis and hepatocellular carcinoma. | Hashem B El-Serag | Gastroenterology | 2012 | 22537432 | No |
| 934 | 3066 | 1533.0 | 83.64 | 41.8 | The future of genetic studies of complex human diseases. | N Risch, K Merikangas | Science | 1996 | 8801636 | Yes |
| 935 | 3065 | 1532.5 | 104.15 | 52.1 | A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. | Y Matsumura, H Maeda | Cancer Res. | 1986 | 2946403 | Yes |
| 936 | 3065 | 1532.5 | 89.14 | 44.6 | Cutaneous wound healing. | A J Singer, R A Clark | N. Engl. J. Med. | 1999 | 10471461 | No |
| 937 | 3065 | 1532.5 | 96.18 | 48.1 | Protein structure prediction on the Web: a case study using the Phyre server. | Lawrence A Kelley, Michael J E Sternberg | Nat Protoc | 2009 | 19247286 | Yes |
| 938 | 1532 | 1532.0 | 34.4 | 34.4 | Signalling pathways of the TNF superfamily: a double-edged sword. | Bharat B Aggarwal | Nat. Rev. Immunol. | 2003 | 12949498 | No |
| 939 | 4591 | 1530.3 | 137.11 | 45.7 | ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. | Kai Wang, Mingyao Li, Hakon Hakonarson | Nucleic Acids Res. | 2010 | 20601685 | Yes |
| 940 | 1530 | 1530.0 | 63.9 | 63.9 | Plant products as antimicrobial agents. | M M Cowan | Clin. Microbiol. Rev. | 1999 | 10515903 | No |
| 941 | 1528 | 1528.0 | 45.71 | 45.7 | Flow-mediated endothelial mechanotransduction. | P F Davies | Physiol. Rev. | 1995 | 7624393 | No |
| 942 | 1528 | 1528.0 | 0.0 | 0.0 | MECHANISM OF SUSTAINED-ACTION MEDICATION. THEORETICAL ANALYSIS OF RATE OF RELEASE OF SOLID DRUGS DISPERSED IN SOLID MATRICES. | T HIGUCHI | J Pharm Sci | 1963 | 14088963 | Yes |
| 943 | 4583 | 1527.7 | 150.29 | 50.1 | Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. | F E Harrell, K L Lee, D B Mark | Stat Med | 1996 | 8668867 | No |
| 944 | 3054 | 1527.0 | 67.91 | 34.0 | Smad-dependent and Smad-independent pathways in TGF-beta family signalling. | Rik Derynck, Ying E Zhang | Nature | 2003 | 14534577 | No |
| 945 | 3047 | 1523.5 | 101.06 | 50.5 | Distributed hierarchical processing in the primate cerebral cortex. | D J Felleman, D C Van Essen | Cereb. Cortex | 1991 | 1822724 | No |
| 946 | 1523 | 1523.0 | 52.24 | 52.2 | The importance of selenium to human health. | M P Rayman | Lancet | 2000 | 10963212 | No |
| 947 | 1522 | 1522.0 | 85.42 | 85.4 | A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. | E L Bradley | Arch Surg | 1993 | 8489394 | No |
| 948 | 1522 | 1522.0 | 40.02 | 40.0 | Cellular mechanisms of insulin resistance. | G I Shulman | J. Clin. Invest. | 2000 | 10903330 | No |
| 949 | 3041 | 1520.5 | 63.4 | 31.7 | Rho GTPases in cell biology. | Sandrine Etienne-Manneville, Alan Hall | Nature | 2002 | 12478284 | No |
| 950 | 1520 | 1520.0 | 34.19 | 34.2 | Approaching the asymptote? Evolution and revolution in immunology. | C A Janeway | Cold Spring Harb. Symp. Quant. Biol. | 1989 | 2700931 | No |
| 951 | 1520 | 1520.0 | 0.0 | 0.0 | Evaluating the quality of medical care. | A Donabedian | Milbank Mem Fund Q | 1966 | 5338568 | No |
| 952 | 1518 | 1518.0 | 31.32 | 31.3 | Signaling--2000 and beyond. | T Hunter | Cell | 2000 | 10647936 | No |
| 953 | 4552 | 1517.3 | 96.11 | 32.0 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. | Jason D Fontenot, Marc A Gavin, Alexander Y Rudensky | Nat. Immunol. | 2003 | 12612578 | Yes |
| 954 | 4550 | 1516.7 | 153.37 | 51.1 | Immunity, inflammation, and cancer. | Sergei I Grivennikov, Florian R Greten, Michael Karin | Cell | 2010 | 20303878 | No |
| 955 | 3032 | 1516.0 | 0.0 | 0.0 | Some quantitative uses of drug antagonists. | O ARUNLAKSHANA, H O SCHILD | Br J Pharmacol Chemother | 1959 | 13651579 | Yes |
| 956 | 1515 | 1515.0 | 37.52 | 37.5 | Theta oscillations in the hippocampus. | György Buzsáki | Neuron | 2002 | 11832222 | No |
| 957 | 1515 | 1515.0 | 0.0 | 0.0 | On respiratory impairment in cancer cells. | O WARBURG | Science | 1956 | 13351639 | Yes |
| 958 | 1514 | 1514.0 | 84.73 | 84.7 | The quality of care. How can it be assessed? | A Donabedian | JAMA | 1988 | 3045356 | No |
| 959 | 1513 | 1513.0 | 0.0 | 0.0 | Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. | M J Casadaban | J. Mol. Biol. | 1976 | 781293 | Yes |
| 960 | 1513 | 1513.0 | 37.29 | 37.3 | TRP channels as cellular sensors. | David E Clapham | Nature | 2003 | 14654832 | No |
| 961 | 1512 | 1512.0 | 78.77 | 78.8 | Predicting basal metabolic rate, new standards and review of previous work. | W N Schofield | Hum Nutr Clin Nutr | 1985 | 4044297 | Yes |
| 962 | 3021 | 1510.5 | 0.0 | 0.0 | On the size of the active site in proteases. I. Papain. | I Schechter, A Berger | Biochem. Biophys. Res. Commun. | 1967 | 6035483 | Yes |
| 963 | 1510 | 1510.0 | 65.45 | 65.5 | Prooxidant states and tumor promotion. | P A Cerutti | Science | 1985 | 2981433 | No |
| 964 | 1509 | 1509.0 | 49.25 | 49.2 | Bcl-2 and the regulation of programmed cell death. | J C Reed | J. Cell Biol. | 1994 | 8294493 | No |
| 965 | 1509 | 1509.0 | 42.29 | 42.3 | DAMPs, PAMPs and alarmins: all we need to know about danger. | Marco E Bianchi | J. Leukoc. Biol. | 2007 | 17032697 | No |
| 966 | 3016 | 1508.0 | 98.52 | 49.3 | Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. | P Liang, A B Pardee | Science | 1992 | 1354393 | Yes |
| 967 | 1508 | 1508.0 | 60.45 | 60.5 | ATP-regulated K+ channels in cardiac muscle. | A Noma | Nature | 1983 | 6310409 | Yes |
| 968 | 4520 | 1506.7 | 157.67 | 52.6 | Quantum mechanical continuum solvation models. | Jacopo Tomasi, Benedetta Mennucci, Roberto Cammi | Chem. Rev. | 2005 | 16092826 | Yes |
| 969 | 1506 | 1506.0 | 0.0 | 0.0 | Protein denaturation. | C Tanford | Adv. Protein Chem. | 1968 | 4882248 | No |
| 970 | 1506 | 1506.0 | 82.46 | 82.5 | Central sensitization: implications for the diagnosis and treatment of pain. | Clifford J Woolf | Pain | 2011 | 20961685 | No |
| 971 | 1504 | 1504.0 | 84.08 | 84.1 | The Children's Depression, Inventory (CDI). | M Kovacs | Psychopharmacol Bull | 1985 | 4089116 | Yes |
| 972 | 6016 | 1504.0 | 172.12 | 43.0 | Matrix elasticity directs stem cell lineage specification. | Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E Discher | Cell | 2006 | 16923388 | Yes |
| 973 | 4506 | 1502.0 | 119.5 | 39.8 | APE: Analyses of Phylogenetics and Evolution in R language. | Emmanuel Paradis, Julien Claude, Korbinian Strimmer | Bioinformatics | 2004 | 14734327 | Yes |
| 974 | 3002 | 1501.0 | 0.0 | 0.0 | A SIMPLIFIED LEAD CITRATE STAIN FOR USE IN ELECTRON MICROSCOPY. | J H VENABLE, R COGGESHALL | J. Cell Biol. | 1965 | 14287192 | Yes |
| 975 | 1501 | 1501.0 | 54.03 | 54.0 | Parkinson's disease: clinical features and diagnosis. | J Jankovic | J. Neurol. Neurosurg. Psychiatry | 2008 | 18344392 | No |
| 976 | 1500 | 1500.0 | 57.05 | 57.0 | Inhibited spontaneous emission in solid-state physics and electronics. | Yablonovitch | Phys. Rev. Lett. | 1987 | 10034639 | Yes |
| 977 | 2998 | 1499.0 | 0.0 | 0.0 | Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. | R B Devereux, N Reichek | Circulation | 1977 | 138494 | Yes |
| 978 | 1498 | 1498.0 | 62.94 | 62.9 | The use of a plus-maze to measure anxiety in the mouse. | R G Lister | Psychopharmacology (Berl.) | 1987 | 3110839 | Yes |
| 979 | 1497 | 1497.0 | 51.15 | 51.1 | Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. | Claudiu T Supuran | Nat Rev Drug Discov | 2008 | 18167490 | No |
| 980 | 1496 | 1496.0 | 0.0 | 0.0 | Removal of fatty acids from serum albumin by charcoal treatment. | R F Chen | J. Biol. Chem. | 1967 | 6016603 | Yes |
| 981 | 4487 | 1495.7 | 175.59 | 58.5 | Cell death: the significance of apoptosis. | A H Wyllie, J F Kerr, A R Currie | Int. Rev. Cytol. | 1980 | 7014501 | No |
| 982 | 2990 | 1495.0 | 70.49 | 35.2 | Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. | C D Nobes, A Hall | Cell | 1995 | 7536630 | Yes |
| 983 | 1495 | 1495.0 | 42.76 | 42.8 | Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. | G Trinchieri | Annu. Rev. Immunol. | 1995 | 7612223 | No |
| 984 | 1494 | 1494.0 | 70.23 | 70.2 | Determination of glutathione and glutathione disulfide in biological samples. | M E Anderson | Meth. Enzymol. | 1985 | 4088074 | Yes |
| 985 | 10458 | 1494.0 | 266.58 | 38.1 | Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. | Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman | Genome Biol. | 2002 | 12184808 | Yes |
| 986 | 1494 | 1494.0 | 42.14 | 42.1 | The global health burden of infection-associated cancers in the year 2002. | Donald Maxwell Parkin | Int. J. Cancer | 2006 | 16404738 | Yes |
| 987 | 1493 | 1493.0 | 76.26 | 76.3 | Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. | B N Ames | Science | 1983 | 6351251 | No |
| 988 | 1493 | 1493.0 | 38.29 | 38.3 | Neutrophils and immunity: challenges and opportunities. | Carl Nathan | Nat. Rev. Immunol. | 2006 | 16498448 | No |
| 989 | 4473 | 1491.0 | 163.19 | 54.4 | The brain's default network: anatomy, function, and relevance to disease. | Randy L Buckner, Jessica R Andrews-Hanna, Daniel L Schacter | Ann. N. Y. Acad. Sci. | 2008 | 18400922 | No |
| 990 | 1490 | 1490.0 | 78.66 | 78.7 | Calmodulin plays a pivotal role in cellular regulation. | W Y Cheung | Science | 1980 | 6243188 | No |
| 991 | 5957 | 1489.2 | 164.77 | 41.2 | Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. | A Shevchenko, M Wilm, O Vorm, M Mann | Anal. Chem. | 1996 | 8779443 | Yes |
| 992 | 1489 | 1489.0 | 33.36 | 33.4 | Antiviral actions of interferons. | C E Samuel | Clin. Microbiol. Rev. | 2001 | 11585785 | No |
| 993 | 1488 | 1488.0 | 0.0 | 0.0 | Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. | O SMITHIES | Biochem. J. | 1955 | 13276348 | Yes |
| 994 | 2975 | 1487.5 | 0.0 | 0.0 | Loss of recent memory after bilateral hippocampal lesions. | W B SCOVILLE, B MILNER | J. Neurol. Neurosurg. Psychiatry | 1957 | 13406589 | Yes |
| 995 | 1487 | 1487.0 | 42.29 | 42.3 | Evolutionary relationship of DNA sequences in finite populations. | F Tajima | Genetics | 1983 | 6628982 | Yes |
| 996 | 2972 | 1486.0 | 72.67 | 36.3 | Lessons from hereditary colorectal cancer. | K W Kinzler, B Vogelstein | Cell | 1996 | 8861899 | No |
| 997 | 1485 | 1485.0 | 48.34 | 48.3 | The molecular pathology of Alzheimer's disease. | D J Selkoe | Neuron | 1991 | 1673054 | No |
| 998 | 2970 | 1485.0 | 0.0 | 0.0 | A complementation analysis of the restriction and modification of DNA in Escherichia coli. | H W Boyer, D Roulland-Dussoix | J. Mol. Biol. | 1969 | 4896022 | Yes |
| 999 | 1485 | 1485.0 | 0.0 | 0.0 | Analysis of tissue and arterial blood temperatures in the resting human forearm. | H H PENNES | J Appl Physiol | 1948 | 18887578 | Yes |
| 1000 | 1484 | 1484.0 | 47.95 | 48.0 | The physiology of glucagon-like peptide 1. | Jens Juul Holst | Physiol. Rev. | 2007 | 17928588 | No |
| 1001 | 1483 | 1483.0 | 64.46 | 64.5 | Simplified calculation of body-surface area. | R D Mosteller | N. Engl. J. Med. | 1987 | 3657876 | Yes |
| 1002 | 1483 | 1483.0 | 44.77 | 44.8 | Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. | Fiona Turnbull | Lancet | 2003 | 14615107 | Yes |
| 1003 | 1482 | 1482.0 | 0.0 | 0.0 | The catecholamine hypothesis of affective disorders: a review of supporting evidence. | J J Schildkraut | Am J Psychiatry | 1965 | 5319766 | No |
| 1004 | 1482 | 1482.0 | 47.8 | 47.8 | The blood-brain barrier in health and chronic neurodegenerative disorders. | Berislav V Zlokovic | Neuron | 2008 | 18215617 | No |
| 1005 | 1478 | 1478.0 | 35.78 | 35.8 | Thrombin signalling and protease-activated receptors. | S R Coughlin | Nature | 2000 | 11001069 | No |
| 1006 | 1476 | 1476.0 | 35.99 | 36.0 | Exploring complex networks. | S H Strogatz | Nature | 2001 | 11258382 | No |
| 1007 | 1476 | 1476.0 | 64.46 | 64.5 | Health consequences of intimate partner violence. | Jacquelyn C Campbell | Lancet | 2002 | 11965295 | No |
| 1008 | 1473 | 1473.0 | 55.63 | 55.6 | Protein oxidation and aging. | E R Stadtman | Science | 1992 | 1355616 | No |
| 1009 | 1473 | 1473.0 | 32.42 | 32.4 | MicroRNA biogenesis: coordinated cropping and dicing. | V Narry Kim | Nat. Rev. Mol. Cell Biol. | 2005 | 15852042 | No |
| 1010 | 1473 | 1473.0 | 97.86 | 97.9 | Interrater reliability: the kappa statistic. | Mary L McHugh | Biochem Med (Zagreb) | 2012 | 23092060 | Yes |
| 1011 | 1472 | 1472.0 | 35.81 | 35.8 | Structure and regulation of voltage-gated Ca2+ channels. | W A Catterall | Annu. Rev. Cell Dev. Biol. | 2000 | 11031246 | No |
| 1012 | 1472 | 1472.0 | 31.66 | 31.7 | Notch signalling: a simple pathway becomes complex. | Sarah J Bray | Nat. Rev. Mol. Cell Biol. | 2006 | 16921404 | No |
| 1013 | 1471 | 1471.0 | 0.0 | 0.0 | Inositol phospholipids and cell surface receptor function. | R H Michell | Biochim. Biophys. Acta | 1975 | 164246 | No |
| 1014 | 1469 | 1469.0 | 40.71 | 40.7 | Targeting PI3K signalling in cancer: opportunities, challenges and limitations. | Jeffrey A Engelman | Nat. Rev. Cancer | 2009 | 19629070 | No |
| 1015 | 2934 | 1467.0 | 96.1 | 48.0 | The heat-shock proteins. | S Lindquist, E A Craig | Annu. Rev. Genet. | 1988 | 2853609 | No |
| 1016 | 1467 | 1467.0 | 35.58 | 35.6 | Developmental regulation of the growth plate. | Henry M Kronenberg | Nature | 2003 | 12748651 | No |
| 1017 | 1465 | 1465.0 | 0.0 | 0.0 | The plasma lecithins:cholesterol acyltransferase reaction. | J A Glomset | J. Lipid Res. | 1968 | 4868699 | No |
| 1018 | 2930 | 1465.0 | 168.98 | 84.5 | The Brief Symptom Inventory: an introductory report. | L R Derogatis, N Melisaratos | Psychol Med | 1983 | 6622612 | Yes |
| 1019 | 1464 | 1464.0 | 75.48 | 75.5 | Missing data analysis: making it work in the real world. | John W Graham | Annu Rev Psychol | 2009 | 18652544 | No |
| 1020 | 1463 | 1463.0 | 53.51 | 53.5 | Excitotoxic cell death. | D W Choi | J. Neurobiol. | 1992 | 1361523 | No |
| 1021 | 1463 | 1463.0 | 40.51 | 40.5 | Global cancer statistics in the year 2000. | D M Parkin | Lancet Oncol. | 2001 | 11905707 | No |
| 1022 | 1462 | 1462.0 | 47.3 | 47.3 | Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. | Gökhan S Hotamisligil | Cell | 2010 | 20303879 | No |
| 1023 | 1461 | 1461.0 | 40.06 | 40.1 | Type III protein secretion systems in bacterial pathogens of animals and plants. | C J Hueck | Microbiol. Mol. Biol. Rev. | 1998 | 9618447 | No |
| 1024 | 1461 | 1461.0 | 32.76 | 32.8 | DNA topoisomerases: structure, function, and mechanism. | J J Champoux | Annu. Rev. Biochem. | 2001 | 11395412 | No |
| 1025 | 4383 | 1461.0 | 112.68 | 37.6 | Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. | Michael W Pfaffl, Graham W Horgan, Leo Dempfle | Nucleic Acids Res. | 2002 | 11972351 | Yes |
| 1026 | 1461 | 1461.0 | 47.32 | 47.3 | Accurate description of van der Waals complexes by density functional theory including empirical corrections. | Stefan Grimme | J Comput Chem | 2004 | 15224390 | Yes |
| 1027 | 5837 | 1459.2 | 272.28 | 68.1 | The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. | T F Heatherton, L T Kozlowski, R C Frecker, K O Fagerström | Br J Addict | 1991 | 1932883 | Yes |
| 1028 | 2918 | 1459.0 | 84.34 | 42.2 | A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. | G Shaw, R Kamen | Cell | 1986 | 3488815 | Yes |
| 1029 | 2916 | 1458.0 | 71.13 | 35.6 | Cell death: critical control points. | Nika N Danial, Stanley J Korsmeyer | Cell | 2004 | 14744432 | No |
| 1030 | 1458 | 1458.0 | 58.05 | 58.0 | The unfolded protein response: controlling cell fate decisions under ER stress and beyond. | Claudio Hetz | Nat. Rev. Mol. Cell Biol. | 2012 | 22251901 | No |
| 1031 | 4373 | 1457.7 | 0.0 | 0.0 | Glucose clamp technique: a method for quantifying insulin secretion and resistance. | R A DeFronzo, J D Tobin, R Andres | Am. J. Physiol. | 1979 | 382871 | Yes |
| 1032 | 1457 | 1457.0 | 47.31 | 47.3 | Epidemiology of insomnia: what we know and what we still need to learn. | Maurice M Ohayon | Sleep Med Rev | 2002 | 12531146 | Yes |
| 1033 | 1456 | 1456.0 | 84.96 | 85.0 | Detecting alcoholism. The CAGE questionnaire. | J A Ewing | JAMA | 1984 | 6471323 | Yes |
| 1034 | 1455 | 1455.0 | 51.65 | 51.6 | Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. | A Dunaif | Endocr. Rev. | 1997 | 9408743 | No |
| 1035 | 5820 | 1455.0 | 133.49 | 33.4 | WebLogo: a sequence logo generator. | Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E Brenner | Genome Res. | 2004 | 15173120 | Yes |
| 1036 | 2907 | 1453.5 | 90.56 | 45.3 | Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. | G G Glenner, C W Wong | Biochem. Biophys. Res. Commun. | 1984 | 6375662 | Yes |
| 1037 | 1453 | 1453.0 | 0.0 | 0.0 | Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? | J V NEEL | Am. J. Hum. Genet. | 1962 | 13937884 | Yes |
| 1038 | 4357 | 1452.3 | 0.0 | 0.0 | Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. | B N Ames, J Mccann, E Yamasaki | Mutat. Res. | 1975 | 768755 | Yes |
| 1039 | 1452 | 1452.0 | 38.14 | 38.1 | A clearer vision for in vivo imaging. | R Weissleder | Nat. Biotechnol. | 2001 | 11283581 | No |
| 1040 | 4355 | 1451.7 | 176.88 | 59.0 | Parallel organization of functionally segregated circuits linking basal ganglia and cortex. | G E Alexander, M R DeLong, P L Strick | Annu. Rev. Neurosci. | 1986 | 3085570 | No |
| 1041 | 2900 | 1450.0 | 97.61 | 48.8 | Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. | K D McCarthy, J de Vellis | J. Cell Biol. | 1980 | 6248568 | Yes |
| 1042 | 1448 | 1448.0 | 71.23 | 71.2 | Why patients use alternative medicine: results of a national study. | J A Astin | JAMA | 1998 | 9605899 | Yes |
| 1043 | 1447 | 1447.0 | 41.87 | 41.9 | Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. | D Lavanchy | J. Viral Hepat. | 2004 | 14996343 | No |
| 1044 | 1447 | 1447.0 | 45.2 | 45.2 | T cell exhaustion. | E John Wherry | Nat. Immunol. | 2011 | 21739672 | No |
| 1045 | 1446 | 1446.0 | 44.25 | 44.2 | Breast cancer and hormone-replacement therapy in the Million Women Study. | Valerie Beral | Lancet | 2003 | 12927427 | Yes |
| 1046 | 2889 | 1444.5 | 77.53 | 38.8 | CAP3: A DNA sequence assembly program. | X Huang, A Madan | Genome Res. | 1999 | 10508846 | Yes |
| 1047 | 1444 | 1444.0 | 30.82 | 30.8 | CD4+ CD25+ suppressor T cells: more questions than answers. | Ethan M Shevach | Nat. Rev. Immunol. | 2002 | 12093005 | No |
| 1048 | 1443 | 1443.0 | 0.0 | 0.0 | Oxygen-dependent microbial killing by phagocytes (first of two parts). | B M Babior | N. Engl. J. Med. | 1978 | 24176 | Yes |
| 1049 | 2886 | 1443.0 | 0.0 | 0.0 | Mathematical model for studying genetic variation in terms of restriction endonucleases. | M Nei, W H Li | Proc. Natl. Acad. Sci. U.S.A. | 1979 | 291943 | Yes |
| 1050 | 2885 | 1442.5 | 91.22 | 45.6 | Assembly of asparagine-linked oligosaccharides. | R Kornfeld, S Kornfeld | Annu. Rev. Biochem. | 1985 | 3896128 | No |
| 1051 | 1442 | 1442.0 | 51.32 | 51.3 | Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. | F Rousset | Genetics | 1997 | 9093870 | Yes |
| 1052 | 1442 | 1442.0 | 35.96 | 36.0 | A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. | J SantaLucia | Proc. Natl. Acad. Sci. U.S.A. | 1998 | 9465037 | Yes |
| 1053 | 1441 | 1441.0 | 0.0 | 0.0 | Mechanisms of action of transmitters and other substances on smooth muscle. | T B Bolton | Physiol. Rev. | 1979 | 37533 | No |
| 1054 | 1441 | 1441.0 | 0.0 | 0.0 | Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. | M Wong-Riley | Brain Res. | 1979 | 223730 | Yes |
| 1055 | 1439 | 1439.0 | 53.46 | 53.5 | A measure of population subdivision based on microsatellite allele frequencies. | M Slatkin | Genetics | 1995 | 7705646 | Yes |
| 1056 | 1437 | 1437.0 | 67.17 | 67.2 | Heavy metal intensification of DAB-based HRP reaction product. | J C Adams | J. Histochem. Cytochem. | 1981 | 7252134 | Yes |
| 1057 | 2869 | 1434.5 | 0.0 | 0.0 | A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. | R F BEERS, I W SIZER | J. Biol. Chem. | 1952 | 14938361 | Yes |
| 1058 | 1432 | 1432.0 | 41.97 | 42.0 | Cancer chemoprevention with dietary phytochemicals. | Young-Joon Surh | Nat. Rev. Cancer | 2003 | 14570043 | No |
| 1059 | 2864 | 1432.0 | 82.09 | 41.0 | Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. | Michael T Lin, M Flint Beal | Nature | 2006 | 17051205 | No |
| 1060 | 1431 | 1431.0 | 60.01 | 60.0 | Epidemiological features of chronic low-back pain. | G B Andersson | Lancet | 1999 | 10470716 | No |
| 1061 | 1430 | 1430.0 | 44.28 | 44.3 | Signal sequences. The limits of variation. | G von Heijne | J. Mol. Biol. | 1985 | 4032478 | Yes |
| 1062 | 1429 | 1429.0 | 0.0 | 0.0 | SELECTION OF HYBRIDS FROM MATINGS OF FIBROBLASTS IN VITRO AND THEIR PRESUMED RECOMBINANTS. | J W LITTLEFIELD | Science | 1964 | 14168277 | Yes |
| 1063 | 1429 | 1429.0 | 47.39 | 47.4 | A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. | Heng Li | Bioinformatics | 2011 | 21903627 | Yes |
| 1064 | 1428 | 1428.0 | 39.65 | 39.6 | Metabolomics--the link between genotypes and phenotypes. | Oliver Fiehn | Plant Mol. Biol. | 2002 | 11860207 | No |
| 1065 | 2855 | 1427.5 | 0.0 | 0.0 | Judgment under Uncertainty: Heuristics and Biases. | A Tversky, D Kahneman | Science | 1974 | 17835457 | Yes |
| 1066 | 1427 | 1427.0 | 102.39 | 102.4 | Determination and quantification of content validity. | M R Lynn | Nurs Res | 1986 | 3640358 | Yes |
| 1067 | 1426 | 1426.0 | 37.92 | 37.9 | Chemokines. | B J Rollins | Blood | 1997 | 9242519 | No |
| 1068 | 9965 | 1423.6 | 268.76 | 38.4 | Induction of pluripotent stem cells from adult human fibroblasts by defined factors. | Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka | Cell | 2007 | 18035408 | Yes |
| 1069 | 2847 | 1423.5 | 162.82 | 81.4 | The Health Belief Model: a decade later. | N K Janz, M H Becker | Health Educ Q | 1984 | 6392204 | No |
| 1070 | 4270 | 1423.3 | 181.08 | 60.4 | AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. | P G Reeves, F H Nielsen, G C Fahey | J. Nutr. | 1993 | 8229312 | No |
| 1071 | 1423 | 1423.0 | 57.82 | 57.8 | Diagnosis of Alzheimer's disease. | Z S Khachaturian | Arch. Neurol. | 1985 | 2864910 | Yes |
| 1072 | 1423 | 1423.0 | 29.97 | 30.0 | Generating samples under a Wright-Fisher neutral model of genetic variation. | Richard R Hudson | Bioinformatics | 2002 | 11847089 | Yes |
| 1073 | 1421 | 1421.0 | 43.0 | 43.0 | Follicular helper CD4 T cells (TFH). | Shane Crotty | Annu. Rev. Immunol. | 2011 | 21314428 | No |
| 1074 | 1417 | 1417.0 | 61.54 | 61.5 | DNA methylation age of human tissues and cell types. | Steve Horvath | Genome Biol. | 2013 | 24138928 | Yes |
| 1075 | 1415 | 1415.0 | 0.0 | 0.0 | Presidential Address-1976. Social support as a moderator of life stress. | S Cobb | Psychosom Med | 1976 | 981490 | Yes |
| 1076 | 1415 | 1415.0 | 28.96 | 29.0 | Maximum-likelihood density modification. | T C Terwilliger | Acta Crystallogr. D Biol. Crystallogr. | 2000 | 10944333 | Yes |
| 1077 | 2828 | 1414.0 | 123.96 | 62.0 | Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. | M H Zweig, G Campbell | Clin. Chem. | 1993 | 8472349 | No |
| 1078 | 1414 | 1414.0 | 43.39 | 43.4 | Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. | R D Pascual-Marqui | Methods Find Exp Clin Pharmacol | 2002 | 12575463 | No |
| 1079 | 7066 | 1413.2 | 228.05 | 45.6 | Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. | Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary King | Diabetes Care | 2004 | 15111519 | Yes |
| 1080 | 7066 | 1413.2 | 199.39 | 39.9 | Mapping and quantifying mammalian transcriptomes by RNA-Seq. | Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara Wold | Nat. Methods | 2008 | 18516045 | Yes |
| 1081 | 1413 | 1413.0 | 56.07 | 56.1 | Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. | R A DeFronzo | Diabetes | 1988 | 3289989 | No |
| 1082 | 2824 | 1412.0 | 0.0 | 0.0 | An efficient mRNA-dependent translation system from reticulocyte lysates. | H R Pelham, R J Jackson | Eur. J. Biochem. | 1976 | 823012 | Yes |
| 1083 | 1411 | 1411.0 | 0.0 | 0.0 | Towards a network theory of the immune system. | N K Jerne | Ann. Immunol. (Paris) | 1974 | 4142565 | No |
| 1084 | 1411 | 1411.0 | 52.43 | 52.4 | The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. | G P Chrousos | N. Engl. J. Med. | 1995 | 7715646 | No |
| 1085 | 2821 | 1410.5 | 79.79 | 39.9 | Measuring the thickness of the human cerebral cortex from magnetic resonance images. | B Fischl, A M Dale | Proc. Natl. Acad. Sci. U.S.A. | 2000 | 10984517 | Yes |
| 1086 | 1409 | 1409.0 | 60.37 | 60.4 | Keratoconus. | Y S Rabinowitz | Surv Ophthalmol | 1998 | 9493273 | No |
| 1087 | 2817 | 1408.5 | 68.86 | 34.4 | Monocyte and macrophage heterogeneity. | Siamon Gordon, Philip R Taylor | Nat. Rev. Immunol. | 2005 | 16322748 | No |
| 1088 | 1408 | 1408.0 | 0.0 | 0.0 | A classification of hand preference by association analysis. | M Annett | Br J Psychol | 1970 | 5457503 | Yes |
| 1089 | 2813 | 1406.5 | 73.53 | 36.8 | Identification of common molecular subsequences. | T F Smith, M S Waterman | J. Mol. Biol. | 1981 | 7265238 | Yes |
| 1090 | 1405 | 1405.0 | 61.08 | 61.1 | Physiological actions of taurine. | R J Huxtable | Physiol. Rev. | 1992 | 1731369 | No |
| 1091 | 5616 | 1404.0 | 282.06 | 70.5 | A simple technique for quantitation of low levels of DNA damage in individual cells. | N P Singh, M T McCoy, R R Tice, E L Schneider | Exp. Cell Res. | 1988 | 3345800 | Yes |
| 1092 | 1404 | 1404.0 | 47.7 | 47.7 | Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. | J Folkman | N. Engl. J. Med. | 1995 | 7491141 | No |
| 1093 | 4208 | 1402.7 | 127.79 | 42.6 | Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. | G S Hotamisligil, N S Shargill, B M Spiegelman | Science | 1993 | 7678183 | Yes |
| 1094 | 2805 | 1402.5 | 0.0 | 0.0 | PREPARATION OF FATTY ACID METHYL ESTERS AND DIMETHYLACETALS FROM LIPIDS WITH BORON FLUORIDE--METHANOL. | W R MORRISON, L M SMITH | J. Lipid Res. | 1964 | 14221106 | Yes |
| 1095 | 1402 | 1402.0 | 37.83 | 37.8 | The synaptic vesicle cycle: a cascade of protein-protein interactions. | T C Südhof | Nature | 1995 | 7791897 | No |
| 1096 | 1401 | 1401.0 | 35.81 | 35.8 | Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. | S L Friedman | J. Biol. Chem. | 2000 | 10644669 | No |
| 1097 | 4199 | 1399.7 | 90.06 | 30.0 | Surfing the p53 network. | B Vogelstein, D Lane, A J Levine | Nature | 2000 | 11099028 | No |
| 1098 | 4194 | 1398.0 | 120.26 | 40.1 | Rapid and efficient site-specific mutagenesis without phenotypic selection. | T A Kunkel, J D Roberts, R A Zakour | Meth. Enzymol. | 1987 | 3323813 | Yes |
| 1099 | 1398 | 1398.0 | 45.04 | 45.0 | Thioredoxin. | A Holmgren | Annu. Rev. Biochem. | 1985 | 3896121 | No |
| 1100 | 1398 | 1398.0 | 40.36 | 40.4 | Inflammatory bowel disease: etiology and pathogenesis. | C Fiocchi | Gastroenterology | 1998 | 9649475 | No |
| 1101 | 2794 | 1397.0 | 88.5 | 44.2 | Alzheimer's disease: the amyloid cascade hypothesis. | J A Hardy, G A Higgins | Science | 1992 | 1566067 | No |
| 1102 | 1396 | 1396.0 | 37.68 | 37.7 | G1 events and regulation of cell proliferation. | A B Pardee | Science | 1989 | 2683075 | No |
| 1103 | 5584 | 1396.0 | 144.83 | 36.2 | Transformation of intact yeast cells treated with alkali cations. | H Ito, Y Fukuda, K Murata, A Kimura | J. Bacteriol. | 1983 | 6336730 | Yes |
| 1104 | 1395 | 1395.0 | 0.0 | 0.0 | Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. | J P Chamberlain | Anal. Biochem. | 1979 | 543547 | Yes |
| 1105 | 1395 | 1395.0 | 56.13 | 56.1 | Archaea in coastal marine environments. | E F DeLong | Proc. Natl. Acad. Sci. U.S.A. | 1992 | 1608980 | Yes |
| 1106 | 1395 | 1395.0 | 58.14 | 58.1 | Social cognitive theory: an agentic perspective. | A Bandura | Annu Rev Psychol | 2001 | 11148297 | Yes |
| 1107 | 2789 | 1394.5 | 84.56 | 42.3 | Receptors for purines and pyrimidines. | V Ralevic, G Burnstock | Pharmacol. Rev. | 1998 | 9755289 | No |
| 1108 | 1394 | 1394.0 | 31.48 | 31.5 | The synaptic vesicle cycle. | Thomas C Sudhof | Annu. Rev. Neurosci. | 2004 | 15217342 | No |
| 1109 | 1393 | 1393.0 | 32.85 | 32.9 | Molecular regulation of vessel maturation. | Rakesh K Jain | Nat. Med. | 2003 | 12778167 | No |
| 1110 | 1393 | 1393.0 | 37.48 | 37.5 | Integrating cell-signalling pathways with NF-kappaB and IKK function. | Neil D Perkins | Nat. Rev. Mol. Cell Biol. | 2007 | 17183360 | No |
| 1111 | 5564 | 1391.0 | 228.78 | 57.2 | Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. | A J Hughes, S E Daniel, L Kilford, A J Lees | J. Neurol. Neurosurg. Psychiatry | 1992 | 1564476 | Yes |
| 1112 | 2781 | 1390.5 | 0.0 | 0.0 | Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. | I W McLean, P K Nakane | J. Histochem. Cytochem. | 1974 | 4374474 | Yes |
| 1113 | 1390 | 1390.0 | 0.0 | 0.0 | The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. | D E Atkinson | Biochemistry | 1968 | 4972613 | Yes |
| 1114 | 2778 | 1389.0 | 83.99 | 42.0 | Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering | Nie, Emory | Science | 1997 | 9027306 | Yes |
| 1115 | 2776 | 1388.0 | 108.82 | 54.4 | Angiogenic factors. | J Folkman, M Klagsbrun | Science | 1987 | 2432664 | No |
| 1116 | 1388 | 1388.0 | 44.02 | 44.0 | Interleukin-2: inception, impact, and implications. | K A Smith | Science | 1988 | 3131876 | No |
| 1117 | 1388 | 1388.0 | 32.8 | 32.8 | Protein homology detection by HMM-HMM comparison. | Johannes Söding | Bioinformatics | 2005 | 15531603 | Yes |
| 1118 | 2770 | 1385.0 | 73.23 | 36.6 | Protein structure comparison by alignment of distance matrices. | L Holm, C Sander | J. Mol. Biol. | 1993 | 8377180 | Yes |
| 1119 | 1385 | 1385.0 | 29.15 | 29.1 | Cellular roles of DNA topoisomerases: a molecular perspective. | James C Wang | Nat. Rev. Mol. Cell Biol. | 2002 | 12042765 | No |
| 1120 | 2770 | 1385.0 | 70.63 | 35.3 | Raster3D: photorealistic molecular graphics. | E A Merritt, D J Bacon | Meth. Enzymol. | 1997 | 18488322 | Yes |
| 1121 | 2768 | 1384.0 | 108.39 | 54.2 | Efficient pseudopotentials for plane-wave calculations. | Troullier, Martins | Phys. Rev., B Condens. Matter | 1991 | 9997467 | Yes |
| 1122 | 1383 | 1383.0 | 36.09 | 36.1 | The distribution of secondary growths in cancer of the breast. 1889. | S Paget | Cancer Metastasis Rev. | 1989 | 2673568 | No |
| 1123 | 1383 | 1383.0 | 40.86 | 40.9 | Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. | Scott L Friedman | Physiol. Rev. | 2008 | 18195085 | No |
| 1124 | 1382 | 1382.0 | 34.05 | 34.0 | Excitatory actions of gaba during development: the nature of the nurture. | Yehezkel Ben-Ari | Nat. Rev. Neurosci. | 2002 | 12209121 | No |
| 1125 | 1381 | 1381.0 | 38.26 | 38.3 | Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. | S A Bustin | J. Mol. Endocrinol. | 2002 | 12200227 | No |
| 1126 | 2760 | 1380.0 | 117.37 | 58.7 | Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. | G Di Chiara, A Imperato | Proc. Natl. Acad. Sci. U.S.A. | 1988 | 2899326 | Yes |
| 1127 | 1380 | 1380.0 | 42.92 | 42.9 | The extracellular matrix: not just pretty fibrils. | Richard O Hynes | Science | 2009 | 19965464 | No |
| 1128 | 1378 | 1378.0 | 34.1 | 34.1 | Bone morphogenetic proteins: multifunctional regulators of vertebrate development. | B L Hogan | Genes Dev. | 1996 | 8682290 | No |
| 1129 | 1377 | 1377.0 | 53.89 | 53.9 | Interleukin-1 and interleukin-1 antagonism. | C A Dinarello | Blood | 1991 | 1826616 | No |
| 1130 | 1377 | 1377.0 | 43.01 | 43.0 | What is cognitive reserve? Theory and research application of the reserve concept. | Yaakov Stern | J Int Neuropsychol Soc | 2002 | 11939702 | No |
| 1131 | 5506 | 1376.5 | 119.42 | 29.9 | Stem cells, cancer, and cancer stem cells. | T Reya, S J Morrison, M F Clarke, I L Weissman | Nature | 2001 | 11689955 | No |
| 1132 | 2753 | 1376.5 | 118.49 | 59.2 | FLASH: fast length adjustment of short reads to improve genome assemblies. | Tanja Magoč, Steven L Salzberg | Bioinformatics | 2011 | 21903629 | Yes |
| 1133 | 2746 | 1373.0 | 154.04 | 77.0 | The MOS social support survey. | C D Sherbourne, A L Stewart | Soc Sci Med | 1991 | 2035047 | Yes |
| 1134 | 1373 | 1373.0 | 71.98 | 72.0 | Approximate entropy as a measure of system complexity. | S M Pincus | Proc. Natl. Acad. Sci. U.S.A. | 1991 | 11607165 | Yes |
| 1135 | 1373 | 1373.0 | 52.11 | 52.1 | TGFβ signalling in context. | Joan Massagué | Nat. Rev. Mol. Cell Biol. | 2012 | 22992590 | No |
| 1136 | 1372 | 1372.0 | 77.02 | 77.0 | A rating scale for drug-induced akathisia. | T R Barnes | Br J Psychiatry | 1989 | 2574607 | Yes |
| 1137 | 1371 | 1371.0 | 0.0 | 0.0 | Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. | P Mitchell | Biol Rev Camb Philos Soc | 1966 | 5329743 | No |
| 1138 | 1371 | 1371.0 | 31.51 | 31.5 | The effect of infections on susceptibility to autoimmune and allergic diseases. | Jean-Francois Bach | N. Engl. J. Med. | 2002 | 12239261 | No |
| 1139 | 1370 | 1370.0 | 0.0 | 0.0 | The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. | G S Manning | Q. Rev. Biophys. | 1978 | 353876 | No |
| 1140 | 4107 | 1369.0 | 113.78 | 37.9 | Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. | A Nicholls, K A Sharp, B Honig | Proteins | 1991 | 1758883 | Yes |
| 1141 | 1369 | 1369.0 | 55.4 | 55.4 | Sick individuals and sick populations. | G Rose | Int J Epidemiol | 1985 | 3872850 | Yes |
| 1142 | 2738 | 1369.0 | 0.0 | 0.0 | Variations in pattern of pubertal changes in girls. | W A Marshall, J M Tanner | Arch. Dis. Child. | 1969 | 5785179 | Yes |
| 1143 | 2738 | 1369.0 | 94.8 | 47.4 | Insulin-like growth factors and their binding proteins: biological actions. | J I Jones, D R Clemmons | Endocr. Rev. | 1995 | 7758431 | No |
| 1144 | 12318 | 1368.7 | 1055.99 | 117.3 | Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. | Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray | Int. J. Cancer | 2015 | 25220842 | Yes |
| 1145 | 1367 | 1367.0 | 0.0 | 0.0 | Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. | E M Witkin | Bacteriol Rev | 1976 | 795416 | No |
| 1146 | 2731 | 1365.5 | 100.51 | 50.3 | Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. | B J Marshall, J R Warren | Lancet | 1984 | 6145023 | Yes |
| 1147 | 2731 | 1365.5 | 86.35 | 43.2 | The mirror-neuron system. | Giacomo Rizzolatti, Laila Craighero | Annu. Rev. Neurosci. | 2004 | 15217330 | No |
| 1148 | 1365 | 1365.0 | 40.21 | 40.2 | The dawning era of polymer therapeutics. | Ruth Duncan | Nat Rev Drug Discov | 2003 | 12750738 | No |
| 1149 | 1364 | 1364.0 | 0.0 | 0.0 | Stereotaxic mapping of the monoamine pathways in the rat brain. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4109331 | Yes |
| 1150 | 1363 | 1363.0 | 33.57 | 33.6 | Neuronal calcium signaling. | M J Berridge | Neuron | 1998 | 9697848 | No |
| 1151 | 1363 | 1363.0 | 42.47 | 42.5 | THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. | Kozi Asada | Annu. Rev. Plant Physiol. Plant Mol. Biol. | 1999 | 15012221 | Yes |
| 1152 | 2722 | 1361.0 | 74.67 | 37.3 | Amino acid substitution matrices from protein blocks. | S Henikoff, J G Henikoff | Proc. Natl. Acad. Sci. U.S.A. | 1992 | 1438297 | Yes |
| 1153 | 1361 | 1361.0 | 62.2 | 62.2 | Recognition-by-components: a theory of human image understanding. | Irving Biederman | Psychol Rev | 1987 | 3575582 | Yes |
| 1154 | 2718 | 1359.0 | 0.0 | 0.0 | Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. | J G Rheinwald, H Green | Cell | 1975 | 1052771 | Yes |
| 1155 | 1359 | 1359.0 | 80.12 | 80.1 | Role of endothelium in responses of vascular smooth muscle. | R F Furchgott | Circ. Res. | 1983 | 6313250 | No |
| 1156 | 2718 | 1359.0 | 81.15 | 40.6 | Matrix metalloproteinases. | H Nagase, J F Woessner | J. Biol. Chem. | 1999 | 10419448 | No |
| 1157 | 1358 | 1358.0 | 42.38 | 42.4 | Neurotrophins and neuronal plasticity. | H Thoenen | Science | 1995 | 7570017 | No |
| 1158 | 1358 | 1358.0 | 40.47 | 40.5 | Interfaces and the driving force of hydrophobic assembly. | David Chandler | Nature | 2005 | 16193038 | No |
| 1159 | 2715 | 1357.5 | 118.43 | 59.2 | Oxygen toxicity, oxygen radicals, transition metals and disease. | B Halliwell, J M Gutteridge | Biochem. J. | 1984 | 6326753 | No |
| 1160 | 1357 | 1357.0 | 0.0 | 0.0 | Dendritic organization in the neurons of the visual and motor cortices of the cat. | D A SHOLL | J. Anat. | 1953 | 13117757 | Yes |
| 1161 | 2713 | 1356.5 | 66.3 | 33.1 | Integrin signaling. | F G Giancotti, E Ruoslahti | Science | 1999 | 10446041 | No |
| 1162 | 4068 | 1356.0 | 165.6 | 55.2 | Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. | R L Spitzer, K Kroenke, J B Williams | JAMA | 1999 | 10568646 | Yes |
| 1163 | 1356 | 1356.0 | 39.85 | 39.9 | Clinical application of C-reactive protein for cardiovascular disease detection and prevention. | Paul M Ridker | Circulation | 2003 | 12551853 | No |
| 1164 | 1355 | 1355.0 | 58.54 | 58.5 | Drugs of abuse: anatomy, pharmacology and function of reward pathways. | G F Koob | Trends Pharmacol. Sci. | 1992 | 1604710 | No |
| 1165 | 5420 | 1355.0 | 163.07 | 40.8 | Epithelial-mesenchymal transitions in development and disease. | Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela Nieto | Cell | 2009 | 19945376 | No |
| 1166 | 1354 | 1354.0 | 0.0 | 0.0 | Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. | A Breslow | Ann. Surg. | 1970 | 5477666 | Yes |
| 1167 | 1352 | 1352.0 | 83.22 | 83.2 | Performance-oriented assessment of mobility problems in elderly patients. | M E Tinetti | J Am Geriatr Soc | 1986 | 3944402 | Yes |
| 1168 | 1351 | 1351.0 | 30.37 | 30.4 | DNA methylation and human disease. | Keith D Robertson | Nat. Rev. Genet. | 2005 | 16136652 | No |
| 1169 | 1350 | 1350.0 | 0.0 | 0.0 | Positional information and the spatial pattern of cellular differentiation. | L Wolpert | J. Theor. Biol. | 1969 | 4390734 | Yes |
| 1170 | 1350 | 1350.0 | 0.0 | 0.0 | Purinergic nerves. | G Burnstock | Pharmacol. Rev. | 1972 | 4404211 | No |
| 1171 | 1350 | 1350.0 | 0.0 | 0.0 | Pedigrees of some mutant strains of Escherichia coli K-12. | B J Bachmann | Bacteriol Rev | 1972 | 4568763 | No |
| 1172 | 2699 | 1349.5 | 85.04 | 42.5 | Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. | Steven E Nissen, Kathy Wolski | N. Engl. J. Med. | 2007 | 17517853 | Yes |
| 1173 | 1349 | 1349.0 | 43.7 | 43.7 | Chlorpromazine equivalent doses for the newer atypical antipsychotics. | Scott W Woods | J Clin Psychiatry | 2003 | 12823080 | No |
| 1174 | 1349 | 1349.0 | 0.0 | 0.0 | A study of the adrenotropic receptors. | R P AHLQUIST | Am. J. Physiol. | 1948 | 18882199 | Yes |
| 1175 | 2695 | 1347.5 | 86.12 | 43.1 | Cloned glutamate receptors. | M Hollmann, S Heinemann | Annu. Rev. Neurosci. | 1994 | 8210177 | No |
| 1176 | 2695 | 1347.5 | 0.0 | 0.0 | Genetic regulatory mechanisms in the synthesis of proteins. | F JACOB, J MONOD | J. Mol. Biol. | 1961 | 13718526 | Yes |
| 1177 | 1347 | 1347.0 | 39.42 | 39.4 | A theory of cortical responses. | Karl Friston | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | 2005 | 15937014 | No |
| 1178 | 2693 | 1346.5 | 98.06 | 49.0 | New perspectives in cell adhesion: RGD and integrins. | E Ruoslahti, M D Pierschbacher | Science | 1987 | 2821619 | No |
| 1179 | 1346 | 1346.0 | 35.97 | 36.0 | Animal mitochondrial genomes. | J L Boore | Nucleic Acids Res. | 1999 | 10101183 | No |
| 1180 | 1345 | 1345.0 | 0.0 | 0.0 | A theory of cerebellar cortex. | D Marr | J. Physiol. (Lond.) | 1969 | 5784296 | Yes |
| 1181 | 1342 | 1342.0 | 29.13 | 29.1 | Network motifs: theory and experimental approaches. | Uri Alon | Nat. Rev. Genet. | 2007 | 17510665 | No |
| 1182 | 9375 | 1339.3 | 433.28 | 61.9 | Assessing the quality of reports of randomized clinical trials: is blinding necessary? | A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuay | Control Clin Trials | 1996 | 8721797 | Yes |
| 1183 | 1339 | 1339.0 | 96.11 | 96.1 | The assessment of clinical skills/competence/performance. | G E Miller | Acad Med | 1990 | 2400509 | Yes |
| 1184 | 1338 | 1338.0 | 36.47 | 36.5 | Getting formal with dopamine and reward. | Wolfram Schultz | Neuron | 2002 | 12383780 | No |
| 1185 | 1338 | 1338.0 | 28.62 | 28.6 | The microRNA Registry. | Sam Griffiths-Jones | Nucleic Acids Res. | 2004 | 14681370 | Yes |
| 1186 | 1336 | 1336.0 | 68.23 | 68.2 | Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. | H U Wittchen | J Psychiatr Res | 1994 | 8064641 | No |
| 1187 | 1336 | 1336.0 | 40.06 | 40.1 | The genetics of ageing. | Cynthia J Kenyon | Nature | 2010 | 20336132 | No |
| 1188 | 2671 | 1335.5 | 147.55 | 73.8 | miRBase: annotating high confidence microRNAs using deep sequencing data. | Ana Kozomara, Sam Griffiths-Jones | Nucleic Acids Res. | 2014 | 24275495 | Yes |
| 1189 | 1335 | 1335.0 | 45.48 | 45.5 | Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. | Robert E Marx | J. Oral Maxillofac. Surg. | 2003 | 12966493 | Yes |
| 1190 | 2669 | 1334.5 | 82.55 | 41.3 | Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. | P J Southern, P Berg | J. Mol. Appl. Genet. | 1982 | 6286831 | Yes |
| 1191 | 1334 | 1334.0 | 40.4 | 40.4 | Dengue and dengue hemorrhagic fever. | D J Gubler | Clin. Microbiol. Rev. | 1998 | 9665979 | No |
| 1192 | 1334 | 1334.0 | 50.55 | 50.5 | Hazards of heavy metal contamination. | Lars Järup | Br. Med. Bull. | 2003 | 14757716 | No |
| 1193 | 1334 | 1334.0 | 34.45 | 34.5 | Recognition of microorganisms and activation of the immune response. | Ruslan Medzhitov | Nature | 2007 | 17943118 | No |
| 1194 | 2666 | 1333.0 | 94.64 | 47.3 | Inositol phosphates and cell signalling. | M J Berridge, R F Irvine | Nature | 1989 | 2550825 | No |
| 1195 | 1333 | 1333.0 | 44.02 | 44.0 | Cell biology and molecular basis of denitrification. | W G Zumft | Microbiol. Mol. Biol. Rev. | 1997 | 9409151 | No |
| 1196 | 1333 | 1333.0 | 46.74 | 46.7 | Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. | E M Wassermann | Electroencephalogr Clin Neurophysiol | 1998 | 9474057 | No |
| 1197 | 1332 | 1332.0 | 0.0 | 0.0 | Evolutionary rate at the molecular level. | M Kimura | Nature | 1968 | 5637732 | Yes |
| 1198 | 1332 | 1332.0 | 29.55 | 29.6 | Cancer and the chemokine network. | Fran Balkwill | Nat. Rev. Cancer | 2004 | 15229479 | No |
| 1199 | 1332 | 1332.0 | 54.44 | 54.4 | Guided Search 2.0 A revised model of visual search. | J M Wolfe | Psychon Bull Rev | 1994 | 24203471 | Yes |
| 1200 | 2663 | 1331.5 | 56.05 | 28.0 | SIFT: Predicting amino acid changes that affect protein function. | Pauline C Ng, Steven Henikoff | Nucleic Acids Res. | 2003 | 12824425 | Yes |
| 1201 | 2662 | 1331.0 | 64.61 | 32.3 | Insulin signalling and the regulation of glucose and lipid metabolism. | A R Saltiel, C R Kahn | Nature | 2001 | 11742412 | Yes |
| 1202 | 1331 | 1331.0 | 34.33 | 34.3 | AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. | D Grahame Hardie | Nat. Rev. Mol. Cell Biol. | 2007 | 17712357 | No |
| 1203 | 2661 | 1330.5 | 75.81 | 37.9 | The Fas death factor. | S Nagata, P Golstein | Science | 1995 | 7533326 | No |
| 1204 | 1330 | 1330.0 | 38.0 | 38.0 | Angiogenesis: an organizing principle for drug discovery? | Judah Folkman | Nat Rev Drug Discov | 2007 | 17396134 | No |
| 1205 | 1329 | 1329.0 | 43.6 | 43.6 | The nuclear factor NF-kappaB pathway in inflammation. | Toby Lawrence | Cold Spring Harb Perspect Biol | 2009 | 20457564 | No |
| 1206 | 1329 | 1329.0 | 64.56 | 64.6 | Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. | Lutz Ackermann | Chem. Rev. | 2011 | 21391562 | Yes |
| 1207 | 2653 | 1326.5 | 72.31 | 36.2 | Liver fibrosis. | Ramón Bataller, David A Brenner | J. Clin. Invest. | 2005 | 15690074 | No |
| 1208 | 1326 | 1326.0 | 33.33 | 33.3 | The caveolae membrane system. | R G Anderson | Annu. Rev. Biochem. | 1998 | 9759488 | No |
| 1209 | 1324 | 1324.0 | 29.11 | 29.1 | Hox genes in vertebrate development. | R Krumlauf | Cell | 1994 | 7913880 | No |
| 1210 | 1324 | 1324.0 | 49.47 | 49.5 | Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. | Peter C Austin | Stat Med | 2009 | 19757444 | Yes |
| 1211 | 2647 | 1323.5 | 0.0 | 0.0 | Maturation of the head of bacteriophage T4. I. DNA packaging events. | U K Laemmli, M Favre | J. Mol. Biol. | 1973 | 4204102 | Yes |
| 1212 | 1322 | 1322.0 | 0.0 | 0.0 | High-speed scanning in human memory. | S Sternberg | Science | 1966 | 5939936 | Yes |
| 1213 | 1322 | 1322.0 | 56.86 | 56.9 | Glutamate: a neurotransmitter in mammalian brain. | F Fonnum | J. Neurochem. | 1984 | 6139418 | No |
| 1214 | 1321 | 1321.0 | 83.25 | 83.2 | Brain dopamine receptors. | P Seeman | Pharmacol. Rev. | 1980 | 6117090 | No |
| 1215 | 3959 | 1319.7 | 126.2 | 42.1 | Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. | Z N Oltvai, C L Milliman, S J Korsmeyer | Cell | 1993 | 8358790 | Yes |
| 1216 | 2637 | 1318.5 | 58.66 | 29.3 | Automated MAD and MIR structure solution. | T C Terwilliger, J Berendzen | Acta Crystallogr. D Biol. Crystallogr. | 1999 | 10089316 | Yes |
| 1217 | 2637 | 1318.5 | 66.31 | 33.2 | The epigenomics of cancer. | Peter A Jones, Stephen B Baylin | Cell | 2007 | 17320506 | No |
| 1218 | 1318 | 1318.0 | 26.32 | 26.3 | Cyclin-dependent kinases: engines, clocks, and microprocessors. | D O Morgan | Annu. Rev. Cell Dev. Biol. | 1997 | 9442875 | No |
| 1219 | 1316 | 1316.0 | 37.85 | 37.9 | Effects of cytochalasin and phalloidin on actin. | J A Cooper | J. Cell Biol. | 1987 | 3312229 | No |
| 1220 | 1316 | 1316.0 | 31.17 | 31.2 | Role of angiogenesis in tumor growth and metastasis. | Judah Folkman | Semin. Oncol. | 2002 | 12516034 | No |
| 1221 | 1315 | 1315.0 | 29.64 | 29.6 | Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. | Judith Campisi | Cell | 2005 | 15734683 | No |
| 1222 | 1314 | 1314.0 | 54.83 | 54.8 | Calculation of substrate oxidation rates in vivo from gaseous exchange. | K N Frayn | J Appl Physiol Respir Environ Exerc Physiol | 1983 | 6618956 | Yes |
| 1223 | 14448 | 1313.5 | 329.89 | 30.0 | Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. | Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P Mesirov | Proc. Natl. Acad. Sci. U.S.A. | 2005 | 16199517 | Yes |
| 1224 | 1313 | 1313.0 | 0.0 | 0.0 | Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. | D M Neville | J. Biol. Chem. | 1971 | 5127429 | Yes |
| 1225 | 5249 | 1312.2 | 0.0 | 0.0 | Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. | D J Sahn, A DeMaria, J Kisslo, A Weyman | Circulation | 1978 | 709763 | Yes |
| 1226 | 1312 | 1312.0 | 32.55 | 32.5 | An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. | R M Esnouf | J. Mol. Graph. Model. | 1997 | 9385560 | Yes |
| 1227 | 1311 | 1311.0 | 72.53 | 72.5 | Interleukin-1. | C A Dinarello | Rev. Infect. Dis. | 1984 | 6369481 | No |
| 1228 | 2622 | 1311.0 | 0.0 | 0.0 | Plaque formation and isolation of pure lines with poliomyelitis viruses. | R DULBECCO, M VOGT | J. Exp. Med. | 1954 | 13130792 | Yes |
| 1229 | 2622 | 1311.0 | 76.75 | 38.4 | Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. | Christian Haass, Dennis J Selkoe | Nat. Rev. Mol. Cell Biol. | 2007 | 17245412 | No |
| 1230 | 3932 | 1310.7 | 119.92 | 40.0 | Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. | Earl S Ford, Wayne H Giles, William H Dietz | JAMA | 2002 | 11790215 | Yes |
| 1231 | 2621 | 1310.5 | 67.71 | 33.9 | Parkinson's disease: mechanisms and models. | William Dauer, Serge Przedborski | Neuron | 2003 | 12971891 | No |
| 1232 | 1310 | 1310.0 | 48.52 | 48.5 | Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. | G C Walker | Microbiol. Rev. | 1984 | 6371470 | No |
| 1233 | 9164 | 1309.1 | 275.32 | 39.3 | Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. | William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M Nathan | N. Engl. J. Med. | 2002 | 11832527 | Yes |
| 1234 | 1309 | 1309.0 | 34.97 | 35.0 | Fabrication of novel biomaterials through molecular self-assembly. | Shuguang Zhang | Nat. Biotechnol. | 2003 | 14520402 | No |
| 1235 | 2617 | 1308.5 | 88.86 | 44.4 | Biofilms: survival mechanisms of clinically relevant microorganisms. | Rodney M Donlan, J William Costerton | Clin. Microbiol. Rev. | 2002 | 11932229 | No |
| 1236 | 1308 | 1308.0 | 76.32 | 76.3 | Determinants of low birth weight: methodological assessment and meta-analysis. | M S Kramer | Bull. World Health Organ. | 1987 | 3322602 | No |
| 1237 | 1307 | 1307.0 | 46.94 | 46.9 | Classification of inflammatory bowel disease. | J E Lennard-Jones | Scand. J. Gastroenterol. Suppl. | 1989 | 2617184 | Yes |
| 1238 | 13068 | 1306.8 | 526.28 | 52.6 | The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. | F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S Luthra | Arthritis Rheum. | 1988 | 3358796 | Yes |
| 1239 | 1305 | 1305.0 | 53.57 | 53.6 | An overview of brominated flame retardants in the environment. | Cynthia A de Wit | Chemosphere | 2002 | 11999784 | No |
| 1240 | 1305 | 1305.0 | 43.52 | 43.5 | The comet assay for DNA damage and repair: principles, applications, and limitations. | Andrew R Collins | Mol. Biotechnol. | 2004 | 15004294 | No |
| 1241 | 1304 | 1304.0 | 0.0 | 0.0 | Comparison of the predicted and observed secondary structure of T4 phage lysozyme. | B W Matthews | Biochim. Biophys. Acta | 1975 | 1180967 | Yes |
| 1242 | 1304 | 1304.0 | 45.58 | 45.6 | The complete general secretory pathway in gram-negative bacteria. | A P Pugsley | Microbiol. Rev. | 1993 | 8096622 | No |
| 1243 | 1304 | 1304.0 | 0.0 | 0.0 | Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. | D AMINOFF | Biochem. J. | 1961 | 13860975 | Yes |
| 1244 | 1304 | 1304.0 | 47.81 | 47.8 | Social determinants of health inequalities. | Michael Marmot | Lancet | 2005 | 15781105 | Yes |
| 1245 | 1303 | 1303.0 | 34.26 | 34.3 | DNA topoisomerases. | J C Wang | Annu. Rev. Biochem. | 1996 | 8811192 | No |
| 1246 | 1301 | 1301.0 | 27.43 | 27.4 | Switching and signaling at the telomere. | E H Blackburn | Cell | 2001 | 11572773 | No |
| 1247 | 2600 | 1300.0 | 80.34 | 40.2 | Protein folding in the cell. | M J Gething, J Sambrook | Nature | 1992 | 1731198 | No |
| 1248 | 1300 | 1300.0 | 24.49 | 24.5 | Cell cycle checkpoint signaling through the ATM and ATR kinases. | R T Abraham | Genes Dev. | 2001 | 11544175 | No |
| 1249 | 5200 | 1300.0 | 115.08 | 28.8 | A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. | B M Bolstad, R A Irizarry, M Astrand, T P Speed | Bioinformatics | 2003 | 12538238 | Yes |
| 1250 | 1300 | 1300.0 | 0.0 | 0.0 | POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES. | D E Goldman | J. Gen. Physiol. | 1943 | 19873371 | Yes |
| 1251 | 1299 | 1299.0 | 30.23 | 30.2 | Mechanisms of cancer drug resistance. | Michael M Gottesman | Annu. Rev. Med. | 2002 | 11818492 | No |
| 1252 | 2597 | 1298.5 | 85.69 | 42.8 | Dali server: conservation mapping in 3D. | Liisa Holm, Päivi Rosenström | Nucleic Acids Res. | 2010 | 20457744 | Yes |
| 1253 | 1297 | 1297.0 | 0.0 | 0.0 | Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. | J N Dumont | J. Morphol. | 1972 | 4109871 | Yes |
| 1254 | 3891 | 1297.0 | 107.06 | 35.7 | Inflammation and atherosclerosis. | Peter Libby, Paul M Ridker, Attilio Maseri | Circulation | 2002 | 11877368 | No |
| 1255 | 3888 | 1296.0 | 212.06 | 70.7 | The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. | C A McHorney, J E Ware, A E Raczek | Med Care | 1993 | 8450681 | Yes |
| 1256 | 1296 | 1296.0 | 44.13 | 44.1 | Perceptual symbol systems. | L W Barsalou | Behav Brain Sci | 1999 | 11301525 | No |
| 1257 | 1296 | 1296.0 | 51.67 | 51.7 | Grounded cognition. | Lawrence W Barsalou | Annu Rev Psychol | 2008 | 17705682 | No |
| 1258 | 3879 | 1293.0 | 92.35 | 30.8 | Efficient selection for high-expression transfectants with a novel eukaryotic vector. | H Niwa, K Yamamura, J Miyazaki | Gene | 1991 | 1660837 | Yes |
| 1259 | 1293 | 1293.0 | 53.75 | 53.8 | Intracellular calcium homeostasis. | E Carafoli | Annu. Rev. Biochem. | 1987 | 3304139 | No |
| 1260 | 1292 | 1292.0 | 46.1 | 46.1 | New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. | R Y Tsien | Biochemistry | 1980 | 6770893 | Yes |
| 1261 | 1291 | 1291.0 | 0.0 | 0.0 | Stereological principles for morphometry in electron microscopic cytology. | E R Weibel | Int. Rev. Cytol. | 1969 | 4899604 | No |
| 1262 | 7746 | 1291.0 | 172.84 | 28.8 | Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. | A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C Mello | Nature | 1998 | 9486653 | Yes |
| 1263 | 1291 | 1291.0 | 50.43 | 50.4 | The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. | B L Fredrickson | Am Psychol | 2001 | 11315248 | Yes |
| 1264 | 1291 | 1291.0 | 36.69 | 36.7 | Tumor angiogenesis. | Robert S Kerbel | N. Engl. J. Med. | 2008 | 18463380 | No |
| 1265 | 1290 | 1290.0 | 30.32 | 30.3 | Points of control in inflammation. | Carl Nathan | Nature | 2002 | 12490957 | No |
| 1266 | 1289 | 1289.0 | 34.51 | 34.5 | Structural features in eukaryotic mRNAs that modulate the initiation of translation. | M Kozak | J. Biol. Chem. | 1991 | 1939050 | No |
| 1267 | 2578 | 1289.0 | 110.35 | 55.2 | Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. | R A DeFronzo, E Ferrannini | Diabetes Care | 1991 | 2044434 | No |
| 1268 | 2578 | 1289.0 | 81.5 | 40.8 | Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. | Kresse, Hafner | Phys. Rev., B Condens. Matter | 1994 | 10010505 | Yes |
| 1269 | 3864 | 1288.0 | 105.28 | 35.1 | Click Chemistry: Diverse Chemical Function from a Few Good Reactions. | Hartmuth C. Kolb, M. G. Finn, K. Barry Sharpless | Angew. Chem. Int. Ed. Engl. | 2001 | 11433435 | Yes |
| 1270 | 3858 | 1286.0 | 113.56 | 37.9 | Median-joining networks for inferring intraspecific phylogenies. | H J Bandelt, P Forster, A Röhl | Mol. Biol. Evol. | 1999 | 10331250 | Yes |
| 1271 | 1286 | 1286.0 | 50.5 | 50.5 | The free-energy principle: a unified brain theory? | Karl Friston | Nat. Rev. Neurosci. | 2010 | 20068583 | No |
| 1272 | 3857 | 1285.7 | 111.13 | 37.0 | Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. | Prateek Kumar, Steven Henikoff, Pauline C Ng | Nat Protoc | 2009 | 19561590 | Yes |
| 1273 | 2571 | 1285.5 | 100.32 | 50.2 | Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. | Jeng-Da Chai, Martin Head-Gordon | Phys Chem Chem Phys | 2008 | 18989472 | Yes |
| 1274 | 1285 | 1285.0 | 28.15 | 28.1 | Cell cycle checkpoints: preventing an identity crisis. | S J Elledge | Science | 1996 | 8939848 | No |
| 1275 | 2570 | 1285.0 | 0.0 | 0.0 | Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. | J MARMUR, P DOTY | J. Mol. Biol. | 1962 | 14470099 | Yes |
| 1276 | 2570 | 1285.0 | 99.79 | 49.9 | Wnt/β-catenin signaling and disease. | Hans Clevers, Roel Nusse | Cell | 2012 | 22682243 | No |
| 1277 | 3853 | 1284.3 | 89.33 | 29.8 | A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. | Zhang, Chung, Oldenburg | J Biomol Screen | 1999 | 10838414 | Yes |
| 1278 | 5129 | 1282.2 | 229.86 | 57.5 | SignalP 4.0: discriminating signal peptides from transmembrane regions. | Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik Nielsen | Nat. Methods | 2011 | 21959131 | Yes |
| 1279 | 1282 | 1282.0 | 0.0 | 0.0 | A modified card sorting test sensitive to frontal lobe defects. | H E Nelson | Cortex | 1976 | 1009768 | Yes |
| 1280 | 1282 | 1282.0 | 37.7 | 37.7 | Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. | M J Meaney | Annu. Rev. Neurosci. | 2001 | 11520931 | No |
| 1281 | 2564 | 1282.0 | 126.08 | 63.0 | Extracellular vesicles: exosomes, microvesicles, and friends. | Graça Raposo, Willem Stoorvogel | J. Cell Biol. | 2013 | 23420871 | No |
| 1282 | 1280 | 1280.0 | 57.65 | 57.6 | A cortical network for directed attention and unilateral neglect. | M M Mesulam | Ann. Neurol. | 1981 | 7032417 | No |
| 1283 | 1280 | 1280.0 | 35.15 | 35.1 | Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. | Z Yang | J. Mol. Evol. | 1994 | 7932792 | Yes |
| 1284 | 1280 | 1280.0 | 32.04 | 32.0 | PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. | Michael F. Thomashow | Annu. Rev. Plant Physiol. Plant Mol. Biol. | 1999 | 15012220 | Yes |
| 1285 | 2559 | 1279.5 | 69.8 | 34.9 | Neuronal oscillations in cortical networks. | György Buzsáki, Andreas Draguhn | Science | 2004 | 15218136 | No |
| 1286 | 2558 | 1279.0 | 53.42 | 26.7 | Cellular motility driven by assembly and disassembly of actin filaments. | Thomas D Pollard, Gary G Borisy | Cell | 2003 | 12600310 | No |
| 1287 | 1278 | 1278.0 | 63.22 | 63.2 | Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. | D R Janero | Free Radic. Biol. Med. | 1990 | 2079232 | No |
| 1288 | 1278 | 1278.0 | 42.96 | 43.0 | Intestinal mucosal barrier function in health and disease. | Jerrold R Turner | Nat. Rev. Immunol. | 2009 | 19855405 | No |
| 1289 | 5110 | 1277.5 | 238.61 | 59.7 | Reporting results of cancer treatment. | A B Miller, B Hoogstraten, M Staquet, A Winkler | Cancer | 1981 | 7459811 | Yes |
| 1290 | 1277 | 1277.0 | 36.25 | 36.2 | Cellular basis of working memory. | P S Goldman-Rakic | Neuron | 1995 | 7695894 | No |
| 1291 | 1277 | 1277.0 | 23.16 | 23.2 | Neuronal specification in the spinal cord: inductive signals and transcriptional codes. | T M Jessell | Nat. Rev. Genet. | 2000 | 11262869 | No |
| 1292 | 3829 | 1276.3 | 77.71 | 25.9 | Notch signaling: cell fate control and signal integration in development. | S Artavanis-Tsakonas, M D Rand, R J Lake | Science | 1999 | 10221902 | No |
| 1293 | 1276 | 1276.0 | 42.5 | 42.5 | Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. | H LeVine | Protein Sci. | 1993 | 8453378 | Yes |
| 1294 | 1276 | 1276.0 | 43.31 | 43.3 | The basal ganglia: focused selection and inhibition of competing motor programs. | J W Mink | Prog. Neurobiol. | 1996 | 9004351 | No |
| 1295 | 1275 | 1275.0 | 33.87 | 33.9 | Mammalian G1 cyclins. | C J Sherr | Cell | 1993 | 8513492 | No |
| 1296 | 2550 | 1275.0 | 72.96 | 36.5 | Origins and Mechanisms of miRNAs and siRNAs. | Richard W Carthew, Erik J Sontheimer | Cell | 2009 | 19239886 | No |
| 1297 | 1274 | 1274.0 | 38.96 | 39.0 | Adipose tissue, adipokines, and inflammation. | Giamila Fantuzzi | J. Allergy Clin. Immunol. | 2005 | 15867843 | No |
| 1298 | 1272 | 1272.0 | 37.8 | 37.8 | Precision mapping of quantitative trait loci. | Z B Zeng | Genetics | 1994 | 8013918 | Yes |
| 1299 | 11446 | 1271.8 | 262.64 | 29.2 | Cytoscape: a software environment for integrated models of biomolecular interaction networks. | Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey Ideker | Genome Res. | 2003 | 14597658 | Yes |
| 1300 | 1271 | 1271.0 | 53.49 | 53.5 | Large-scale neurocognitive networks and distributed processing for attention, language, and memory. | M M Mesulam | Ann. Neurol. | 1990 | 2260847 | No |
| 1301 | 2542 | 1271.0 | 57.98 | 29.0 | Upstream and downstream of mTOR. | Nissim Hay, Nahum Sonenberg | Genes Dev. | 2004 | 15314020 | No |
| 1302 | 2542 | 1271.0 | 60.38 | 30.2 | Signaling to NF-kappaB. | Matthew S Hayden, Sankar Ghosh | Genes Dev. | 2004 | 15371334 | No |
| 1303 | 2541 | 1270.5 | 68.71 | 34.4 | Human mesenchymal stem cells modulate allogeneic immune cell responses. | Sudeepta Aggarwal, Mark F Pittenger | Blood | 2005 | 15494428 | Yes |
| 1304 | 1268 | 1268.0 | 51.04 | 51.0 | Health consequences of obesity in youth: childhood predictors of adult disease. | W H Dietz | Pediatrics | 1998 | 12224658 | No |
| 1305 | 7607 | 1267.8 | 295.81 | 49.3 | Cancer statistics, 2009. | Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J Thun | CA Cancer J Clin | 2009 | 19474385 | Yes |
| 1306 | 1267 | 1267.0 | 49.57 | 49.6 | Global epidemiology of oral and oropharyngeal cancer. | Saman Warnakulasuriya | Oral Oncol. | 2009 | 18804401 | No |
| 1307 | 2533 | 1266.5 | 56.07 | 28.0 | Fitting a mixture model by expectation maximization to discover motifs in biopolymers. | T L Bailey, C Elkan | Proc Int Conf Intell Syst Mol Biol | 1994 | 7584402 | Yes |
| 1308 | 1266 | 1266.0 | 0.0 | 0.0 | The micronucleus test. | W Schmid | Mutat. Res. | 1975 | 48190 | Yes |
| 1309 | 1266 | 1266.0 | 0.0 | 0.0 | Mode of cell migration to the superficial layers of fetal monkey neocortex. | P Rakic | J. Comp. Neurol. | 1972 | 4624784 | Yes |
| 1310 | 3798 | 1266.0 | 83.02 | 27.7 | T-Coffee: A novel method for fast and accurate multiple sequence alignment. | C Notredame, D G Higgins, J Heringa | J. Mol. Biol. | 2000 | 10964570 | Yes |
| 1311 | 1265 | 1265.0 | 71.04 | 71.0 | Adverse health effects of high-effort/low-reward conditions. | J Siegrist | J Occup Health Psychol | 1996 | 9547031 | No |
| 1312 | 1265 | 1265.0 | 26.87 | 26.9 | How cells read TGF-beta signals. | J Massagué | Nat. Rev. Mol. Cell Biol. | 2000 | 11252892 | No |
| 1313 | 1264 | 1264.0 | 0.0 | 0.0 | Complete nucleotide sequence of the Escherichia coli plasmid pBR322. | J G Sutcliffe | Cold Spring Harb. Symp. Quant. Biol. | 1979 | 383387 | Yes |
| 1314 | 1264 | 1264.0 | 61.07 | 61.1 | Intermediate filaments as mechanical integrators of cellular space. | E Lazarides | Nature | 1980 | 7188712 | Yes |
| 1315 | 1264 | 1264.0 | 44.99 | 45.0 | Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. | M Leavitt | MedGenMed | 2001 | 11549951 | No |
| 1316 | 12639 | 1263.9 | 536.34 | 53.6 | Measurement of protein using bicinchoninic acid. | P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C Klenk | Anal. Biochem. | 1985 | 3843705 | Yes |
| 1317 | 2527 | 1263.5 | 68.52 | 34.3 | A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. | D Wessel, U I Flügge | Anal. Biochem. | 1984 | 6731838 | Yes |
| 1318 | 1263 | 1263.0 | 38.41 | 38.4 | Drug-like properties and the causes of poor solubility and poor permeability. | C A Lipinski | J Pharmacol Toxicol Methods | 2000 | 11274893 | No |
| 1319 | 2525 | 1262.5 | 73.15 | 36.6 | Empirical threshold values for quantitative trait mapping. | G A Churchill, R W Doerge | Genetics | 1994 | 7851788 | Yes |
| 1320 | 2524 | 1262.0 | 0.0 | 0.0 | Receptive fields and functional architecture of monkey striate cortex. | D H Hubel, T N Wiesel | J. Physiol. (Lond.) | 1968 | 4966457 | Yes |
| 1321 | 1261 | 1261.0 | 42.98 | 43.0 | Biofilms: microbial life on surfaces. | Rodney M Donlan | Emerging Infect. Dis. | 2002 | 12194761 | No |
| 1322 | 2522 | 1261.0 | 63.17 | 31.6 | Complex networks orchestrate epithelial-mesenchymal transitions. | Jean Paul Thiery, Jonathan P Sleeman | Nat. Rev. Mol. Cell Biol. | 2006 | 16493418 | No |
| 1323 | 5044 | 1261.0 | 151.23 | 37.8 | Cancer-related inflammation. | Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill | Nature | 2008 | 18650914 | No |
| 1324 | 13865 | 1260.5 | 410.14 | 37.3 | PLINK: a tool set for whole-genome association and population-based linkage analyses. | Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C Sham | Am. J. Hum. Genet. | 2007 | 17701901 | Yes |
| 1325 | 2520 | 1260.0 | 107.63 | 53.8 | ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. | M Gardes, T D Bruns | Mol. Ecol. | 1993 | 8180733 | Yes |
| 1326 | 1260 | 1260.0 | 33.87 | 33.9 | Pathogenesis of group A streptococcal infections. | M W Cunningham | Clin. Microbiol. Rev. | 2000 | 10885988 | No |
| 1327 | 1259 | 1259.0 | 0.0 | 0.0 | In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. | T R Chen | Exp. Cell Res. | 1977 | 65285 | Yes |
| 1328 | 1259 | 1259.0 | 34.87 | 34.9 | A revolution in optical manipulation. | David G Grier | Nature | 2003 | 12917694 | No |
| 1329 | 2518 | 1259.0 | 70.91 | 35.5 | The BCL-2 protein family: opposing activities that mediate cell death. | Richard J Youle, Andreas Strasser | Nat. Rev. Mol. Cell Biol. | 2008 | 18097445 | No |
| 1330 | 1258 | 1258.0 | 32.81 | 32.8 | An analysis of vertebrate mRNA sequences: intimations of translational control. | M Kozak | J. Cell Biol. | 1991 | 1955461 | No |
| 1331 | 1258 | 1258.0 | 91.6 | 91.6 | Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. | Daniël Lakens | Front Psychol | 2013 | 24324449 | No |
| 1332 | 1257 | 1257.0 | 36.48 | 36.5 | Structural design and molecular evolution of a cytokine receptor superfamily. | J F Bazan | Proc. Natl. Acad. Sci. U.S.A. | 1990 | 2169613 | Yes |
| 1333 | 2514 | 1257.0 | 54.07 | 27.0 | Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. | O Tetsu, F McCormick | Nature | 1999 | 10201372 | Yes |
| 1334 | 1257 | 1257.0 | 34.5 | 34.5 | Hypertrophic cardiomyopathy: a systematic review. | Barry J Maron | JAMA | 2002 | 11886323 | No |
| 1335 | 1256 | 1256.0 | 53.59 | 53.6 | Pineal melatonin: cell biology of its synthesis and of its physiological interactions. | R J Reiter | Endocr. Rev. | 1991 | 1649044 | No |
| 1336 | 10038 | 1254.8 | 396.57 | 49.6 | Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. | R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A Erlich | Science | 1988 | 2448875 | Yes |
| 1337 | 2509 | 1254.5 | 133.23 | 66.6 | A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. | J G Snodgrass, M Vanderwart | J Exp Psychol Hum Learn | 1980 | 7373248 | Yes |
| 1338 | 2509 | 1254.5 | 62.4 | 31.2 | Cell migration: a physically integrated molecular process. | D A Lauffenburger, A F Horwitz | Cell | 1996 | 8608589 | No |
| 1339 | 1254 | 1254.0 | 0.0 | 0.0 | A rating instrument for anxiety disorders. | W W Zung | Psychosomatics | 1971 | 5172928 | Yes |
| 1340 | 1253 | 1253.0 | 58.07 | 58.1 | Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? | B Halliwell | Lancet | 1994 | 7915779 | No |
| 1341 | 1253 | 1253.0 | 33.18 | 33.2 | Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. | M B Luskin | Neuron | 1993 | 8338665 | Yes |
| 1342 | 1253 | 1253.0 | 32.74 | 32.7 | Trastuzumab--mechanism of action and use in clinical practice. | Clifford A Hudis | N. Engl. J. Med. | 2007 | 17611206 | No |
| 1343 | 7516 | 1252.7 | 258.57 | 43.1 | Positional cloning of the mouse obese gene and its human homologue. | Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M Friedman | Nature | 1994 | 7984236 | Yes |
| 1344 | 1252 | 1252.0 | 0.0 | 0.0 | Areas, volumes, packing and protein structure. | F M Richards | Annu. Rev. Biophys. Bioeng. | 1977 | 326146 | No |
| 1345 | 1252 | 1252.0 | 31.62 | 31.6 | Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. | G L Semenza | Annu. Rev. Cell Dev. Biol. | 1999 | 10611972 | No |
| 1346 | 1252 | 1252.0 | 35.71 | 35.7 | Episodic memory: from mind to brain. | Endel Tulving | Annu Rev Psychol | 2002 | 11752477 | Yes |
| 1347 | 1252 | 1252.0 | 34.36 | 34.4 | The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. | Michael R Lieber | Annu. Rev. Biochem. | 2010 | 20192759 | No |
| 1348 | 1252 | 1252.0 | 49.81 | 49.8 | Hypoxia-inducible factors in physiology and medicine. | Gregg L Semenza | Cell | 2012 | 22304911 | No |
| 1349 | 1251 | 1251.0 | 26.97 | 27.0 | Neuroblastoma: biological insights into a clinical enigma. | Garrett M Brodeur | Nat. Rev. Cancer | 2003 | 12612655 | No |
| 1350 | 1251 | 1251.0 | 54.39 | 54.4 | Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. | Sergio Pecorelli | Int J Gynaecol Obstet | 2009 | 19367689 | No |
| 1351 | 2501 | 1250.5 | 0.0 | 0.0 | A fluorometric method for determination of oxidized and reduced glutathione in tissues. | P J Hissin, R Hilf | Anal. Biochem. | 1976 | 962076 | Yes |
| 1352 | 1249 | 1249.0 | 25.91 | 25.9 | Vienna RNA secondary structure server. | Ivo L Hofacker | Nucleic Acids Res. | 2003 | 12824340 | Yes |
| 1353 | 1249 | 1249.0 | 34.83 | 34.8 | Growth of the plant cell wall. | Daniel J Cosgrove | Nat. Rev. Mol. Cell Biol. | 2005 | 16261190 | No |
| 1354 | 2497 | 1248.5 | 123.51 | 61.8 | The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. | A J Stunkard, S Messick | J Psychosom Res | 1985 | 3981480 | Yes |
| 1355 | 1248 | 1248.0 | 35.24 | 35.2 | A cell culture model for T lymphocyte clonal anergy. | R H Schwartz | Science | 1990 | 2113314 | Yes |
| 1356 | 1248 | 1248.0 | 35.66 | 35.7 | An economic method for the fluorescent labeling of PCR fragments. | M Schuelke | Nat. Biotechnol. | 2000 | 10657137 | Yes |
| 1357 | 1248 | 1248.0 | 0.0 | 0.0 | The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. | W W CLELAND | Biochim. Biophys. Acta | 1963 | 14021667 | Yes |
| 1358 | 2496 | 1248.0 | 99.67 | 49.8 | Understanding interobserver agreement: the kappa statistic. | Anthony J Viera, Joanne M Garrett | Fam Med | 2005 | 15883903 | Yes |
| 1359 | 2496 | 1248.0 | 81.79 | 40.9 | The inflammasomes. | Kate Schroder, Jurg Tschopp | Cell | 2010 | 20303873 | No |
| 1360 | 1247 | 1247.0 | 38.82 | 38.8 | Binary Agrobacterium vectors for plant transformation. | M Bevan | Nucleic Acids Res. | 1984 | 6095209 | Yes |
| 1361 | 3741 | 1247.0 | 121.31 | 40.4 | The metabolic syndrome--a new worldwide definition. | K George M M Alberti, Paul Zimmet, Jonathan Shaw | Lancet | 2005 | 16182882 | Yes |
| 1362 | 1246 | 1246.0 | 59.08 | 59.1 | The linear-quadratic formula and progress in fractionated radiotherapy. | J F Fowler | Br J Radiol | 1989 | 2670032 | No |
| 1363 | 1246 | 1246.0 | 45.97 | 46.0 | Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. | Y Ben-Ari | Neuroscience | 1985 | 2859548 | No |
| 1364 | 2491 | 1245.5 | 60.37 | 30.2 | Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. | E Krissinel, K Henrick | Acta Crystallogr. D Biol. Crystallogr. | 2004 | 15572779 | Yes |
| 1365 | 3735 | 1245.0 | 153.93 | 51.3 | Phylogenetic identification and in situ detection of individual microbial cells without cultivation. | R I Amann, W Ludwig, K H Schleifer | Microbiol. Rev. | 1995 | 7535888 | No |
| 1366 | 1245 | 1245.0 | 41.09 | 41.1 | What we can do and what we cannot do with fMRI. | Nikos K Logothetis | Nature | 2008 | 18548064 | No |
| 1367 | 12446 | 1244.6 | 343.81 | 34.4 | Multilineage potential of adult human mesenchymal stem cells. | M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R Marshak | Science | 1999 | 10102814 | Yes |
| 1368 | 2489 | 1244.5 | 59.84 | 29.9 | The Ki-67 protein: from the known and the unknown. | T Scholzen, J Gerdes | J. Cell. Physiol. | 2000 | 10653597 | No |
| 1369 | 1244 | 1244.0 | 52.57 | 52.6 | Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. | D W Choi | Trends Neurosci. | 1988 | 2469166 | No |
| 1370 | 2488 | 1244.0 | 88.93 | 44.5 | Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. | P J Basser, C Pierpaoli | J Magn Reson B | 1996 | 8661285 | Yes |
| 1371 | 1244 | 1244.0 | 44.5 | 44.5 | Flavonoids as antioxidants. | P G Pietta | J. Nat. Prod. | 2000 | 10924197 | No |
| 1372 | 1244 | 1244.0 | 44.66 | 44.7 | The in vitro micronucleus technique. | M Fenech | Mutat. Res. | 2000 | 11113469 | No |
| 1373 | 3732 | 1244.0 | 91.67 | 30.6 | An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. | J K Eng, A L McCormack, J R Yates | J. Am. Soc. Mass Spectrom. | 1994 | 24226387 | Yes |
| 1374 | 1243 | 1243.0 | 50.69 | 50.7 | Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. | M Zasloff | Proc. Natl. Acad. Sci. U.S.A. | 1987 | 3299384 | Yes |
| 1375 | 1243 | 1243.0 | 44.81 | 44.8 | Introduction and General Overview of Cyclodextrin Chemistry. | József Szejtli | Chem. Rev. | 1998 | 11848947 | Yes |
| 1376 | 1243 | 1243.0 | 0.0 | 0.0 | A METHOD OF MEASURING EYE MOVEMENT USING A SCLERAL SEARCH COIL IN A MAGNETIC FIELD. | D A ROBINSON | IEEE Trans Biomed Eng | 1963 | 14121113 | Yes |
| 1377 | 1242 | 1242.0 | 59.49 | 59.5 | Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. | P Holzer | Pharmacol. Rev. | 1991 | 1852779 | No |
| 1378 | 1242 | 1242.0 | 34.23 | 34.2 | Thiazolidinediones. | Hannele Yki-Järvinen | N. Engl. J. Med. | 2004 | 15356308 | No |
| 1379 | 1241 | 1241.0 | 34.39 | 34.4 | NADPH oxidase: an update. | B M Babior | Blood | 1999 | 10029572 | No |
| 1380 | 1241 | 1241.0 | 40.56 | 40.6 | Oxidative stress and neurodegeneration: where are we now? | Barry Halliwell | J. Neurochem. | 2006 | 16805774 | No |
| 1381 | 2480 | 1240.0 | 83.41 | 41.7 | Rapid and sensitive protein similarity searches. | D J Lipman, W R Pearson | Science | 1985 | 2983426 | Yes |
| 1382 | 1240 | 1240.0 | 31.61 | 31.6 | From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. | W A Catterall | Neuron | 2000 | 10798388 | No |
| 1383 | 2479 | 1239.5 | 57.12 | 28.6 | Toll-like receptor control of the adaptive immune responses. | Akiko Iwasaki, Ruslan Medzhitov | Nat. Immunol. | 2004 | 15454922 | No |
| 1384 | 1239 | 1239.0 | 26.06 | 26.1 | Germinal centers. | I C MacLennan | Annu. Rev. Immunol. | 1994 | 8011279 | No |
| 1385 | 3715 | 1238.3 | 94.51 | 31.5 | Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. | J E Darnell, I M Kerr, G R Stark | Science | 1994 | 8197455 | No |
| 1386 | 1238 | 1238.0 | 0.0 | 0.0 | The Gingival Index, the Plaque Index and the Retention Index Systems. | H Löe | J. Periodontol. | 1967 | 5237684 | Yes |
| 1387 | 4951 | 1237.8 | 141.59 | 35.4 | Improved optimization for the robust and accurate linear registration and motion correction of brain images. | Mark Jenkinson, Peter Bannister, Michael Brady, Stephen Smith | Neuroimage | 2002 | 12377157 | Yes |
| 1388 | 1237 | 1237.0 | 36.48 | 36.5 | Recognition of errors in three-dimensional structures of proteins. | M J Sippl | Proteins | 1993 | 8108378 | Yes |
| 1389 | 1236 | 1236.0 | 0.0 | 0.0 | Statistical analysis of enzyme kinetic data. | W W Cleland | Meth. Enzymol. | 1979 | 502857 | Yes |
| 1390 | 1236 | 1236.0 | 33.84 | 33.8 | Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. | B L Wajchenberg | Endocr. Rev. | 2000 | 11133069 | No |
| 1391 | 1236 | 1236.0 | 26.49 | 26.5 | Protein degradation and protection against misfolded or damaged proteins. | Alfred L Goldberg | Nature | 2003 | 14685250 | No |
| 1392 | 6178 | 1235.6 | 148.88 | 29.8 | Stages of embryonic development of the zebrafish. | C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F Schilling | Dev. Dyn. | 1995 | 8589427 | Yes |
| 1393 | 1235 | 1235.0 | 0.0 | 0.0 | The relationship between the spleen colony-forming cell and the haemopoietic stem cell. | R Schofield | Blood Cells | 1978 | 747780 | Yes |
| 1394 | 1235 | 1235.0 | 39.89 | 39.9 | Leptospirosis. | P N Levett | Clin. Microbiol. Rev. | 2001 | 11292640 | No |
| 1395 | 1234 | 1234.0 | 0.0 | 0.0 | Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. | B E Murphy | J. Clin. Endocrinol. Metab. | 1967 | 4291524 | Yes |
| 1396 | 2465 | 1232.5 | 100.08 | 50.0 | Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. | F Denizot, R Lang | J. Immunol. Methods | 1986 | 3486233 | Yes |
| 1397 | 3696 | 1232.0 | 147.99 | 49.3 | Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. | H Esterbauer, R J Schaur, H Zollner | Free Radic. Biol. Med. | 1991 | 1937131 | No |
| 1398 | 1232 | 1232.0 | 38.68 | 38.7 | Solvent-accessible surfaces of proteins and nucleic acids. | M L Connolly | Science | 1983 | 6879170 | Yes |
| 1399 | 1232 | 1232.0 | 48.43 | 48.4 | Constructions of masculinity and their influence on men's well-being: a theory of gender and health. | W H Courtenay | Soc Sci Med | 2000 | 10741575 | No |
| 1400 | 2464 | 1232.0 | 58.26 | 29.1 | Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. | Gary L Johnson, Razvan Lapadat | Science | 2002 | 12471242 | No |
| 1401 | 2464 | 1232.0 | 70.22 | 35.1 | Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. | Robert Visse, Hideaki Nagase | Circ. Res. | 2003 | 12730128 | No |
| 1402 | 1232 | 1232.0 | 24.62 | 24.6 | Automated electron microscope tomography using robust prediction of specimen movements. | David N Mastronarde | J. Struct. Biol. | 2005 | 16182563 | Yes |
| 1403 | 1231 | 1231.0 | 65.39 | 65.4 | Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. | P Holzer | Neuroscience | 1988 | 3288903 | No |
| 1404 | 1231 | 1231.0 | 0.0 | 0.0 | R factor transfer in Rhizobium leguminosarum. | J E Beringer | J. Gen. Microbiol. | 1974 | 4612098 | Yes |
| 1405 | 1231 | 1231.0 | 42.2 | 42.2 | MYC on the path to cancer. | Chi V Dang | Cell | 2012 | 22464321 | No |
| 1406 | 1230 | 1230.0 | 35.61 | 35.6 | HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. | J M Coffin | Science | 1995 | 7824947 | Yes |
| 1407 | 1230 | 1230.0 | 0.0 | 0.0 | Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. | S COHEN | J. Biol. Chem. | 1962 | 13880319 | Yes |
| 1408 | 2456 | 1228.0 | 0.0 | 0.0 | Prediction of the secondary structure of proteins from their amino acid sequence. | P Y Chou, G D Fasman | Adv. Enzymol. Relat. Areas Mol. Biol. | 1978 | 364941 | No |
| 1409 | 1228 | 1228.0 | 51.9 | 51.9 | Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). | M N Marsh | Gastroenterology | 1992 | 1727768 | No |
| 1410 | 1228 | 1228.0 | 37.53 | 37.5 | From sensation to cognition. | M M Mesulam | Brain | 1998 | 9648540 | No |
| 1411 | 4910 | 1227.5 | 152.85 | 38.2 | p53 mutations in human cancers. | M Hollstein, D Sidransky, B Vogelstein, C C Harris | Science | 1991 | 1905840 | No |
| 1412 | 2454 | 1227.0 | 108.85 | 54.4 | Palladium-catalyzed ligand-directed C-H functionalization reactions. | Thomas W Lyons, Melanie S Sanford | Chem. Rev. | 2010 | 20078038 | No |
| 1413 | 2453 | 1226.5 | 80.4 | 40.2 | Diarrheagenic Escherichia coli. | J P Nataro, J B Kaper | Clin. Microbiol. Rev. | 1998 | 9457432 | No |
| 1414 | 1225 | 1225.0 | 63.4 | 63.4 | Perception of risk. | P Slovic | Science | 1987 | 3563507 | Yes |
| 1415 | 2450 | 1225.0 | 113.01 | 56.5 | Pain assessment: global use of the Brief Pain Inventory. | C S Cleeland, K M Ryan | Ann Acad Med Singap | 1994 | 8080219 | No |
| 1416 | 2449 | 1224.5 | 55.74 | 27.9 | NF-kappaB regulation in the immune system. | Qiutang Li, Inder M Verma | Nat. Rev. Immunol. | 2002 | 12360211 | No |
| 1417 | 2449 | 1224.5 | 82.97 | 41.5 | The unfolded protein response: from stress pathway to homeostatic regulation. | Peter Walter, David Ron | Science | 2011 | 22116877 | No |
| 1418 | 1224 | 1224.0 | 60.74 | 60.7 | Probiotics in man and animals. | R Fuller | J. Appl. Bacteriol. | 1989 | 2666378 | No |
| 1419 | 1223 | 1223.0 | 35.24 | 35.2 | The biology of incretin hormones. | Daniel J Drucker | Cell Metab. | 2006 | 16517403 | No |
| 1420 | 1222 | 1222.0 | 0.0 | 0.0 | Selforganization of matter and the evolution of biological macromolecules. | M Eigen | Naturwissenschaften | 1971 | 4942363 | No |
| 1421 | 2442 | 1221.0 | 0.0 | 0.0 | Multiple receptors for dopamine. | J W Kebabian, D B Calne | Nature | 1979 | 215920 | No |
| 1422 | 6105 | 1221.0 | 184.02 | 36.8 | Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. | Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan Hsu | N. Engl. J. Med. | 2004 | 15385656 | Yes |
| 1423 | 1220 | 1220.0 | 39.61 | 39.6 | Oxidative stress hypothesis in Alzheimer's disease. | W R Markesbery | Free Radic. Biol. Med. | 1997 | 9165306 | No |
| 1424 | 1220 | 1220.0 | 37.17 | 37.2 | An index to quantify an individual's scientific research output. | J E Hirsch | Proc. Natl. Acad. Sci. U.S.A. | 2005 | 16275915 | Yes |
| 1425 | 3659 | 1219.7 | 111.1 | 37.0 | Canonical sampling through velocity rescaling. | Giovanni Bussi, Davide Donadio, Michele Parrinello | J Chem Phys | 2007 | 17212484 | Yes |
| 1426 | 2439 | 1219.5 | 196.22 | 98.1 | A clinical method of functional assessment of the shoulder. | C R Constant, A H Murley | Clin. Orthop. Relat. Res. | 1987 | 3791738 | Yes |
| 1427 | 2438 | 1219.0 | 0.0 | 0.0 | The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. | J Shine, L Dalgarno | Proc. Natl. Acad. Sci. U.S.A. | 1974 | 4598299 | Yes |
| 1428 | 1219 | 1219.0 | 34.25 | 34.2 | The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. | D M Kingsley | Genes Dev. | 1994 | 8299934 | No |
| 1429 | 1218 | 1218.0 | 36.85 | 36.9 | The corticosteroid receptor hypothesis of depression. | F Holsboer | Neuropsychopharmacology | 2000 | 11027914 | No |
| 1430 | 1218 | 1218.0 | 0.0 | 0.0 | Cerebral vascular accidents in patients over the age of 60. II. Prognosis. | J RANKIN | Scott Med J | 1957 | 13432835 | Yes |
| 1431 | 4871 | 1217.8 | 148.01 | 37.0 | Use of T7 RNA polymerase to direct expression of cloned genes. | F W Studier, A H Rosenberg, J J Dunn, J W Dubendorff | Meth. Enzymol. | 1990 | 2199796 | Yes |
| 1432 | 1217 | 1217.0 | 30.03 | 30.0 | An approximately unbiased test of phylogenetic tree selection. | Hidetoshi Shimodaira | Syst. Biol. | 2002 | 12079646 | Yes |
| 1433 | 1217 | 1217.0 | 28.57 | 28.6 | Neurotrophins and their receptors: a convergence point for many signalling pathways. | Moses V Chao | Nat. Rev. Neurosci. | 2003 | 12671646 | No |
| 1434 | 2434 | 1217.0 | 66.73 | 33.4 | PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. | Alexander W Schüttelkopf, Daan M F van Aalten | Acta Crystallogr. D Biol. Crystallogr. | 2004 | 15272157 | Yes |
| 1435 | 3650 | 1216.7 | 117.52 | 39.2 | The fusiform face area: a module in human extrastriate cortex specialized for face perception. | N Kanwisher, J McDermott, M M Chun | J. Neurosci. | 1997 | 9151747 | Yes |
| 1436 | 2432 | 1216.0 | 0.0 | 0.0 | Polymyositis and dermatomyositis (first of two parts). | A Bohan, J B Peter | N. Engl. J. Med. | 1975 | 1090839 | No |
| 1437 | 1216 | 1216.0 | 46.83 | 46.8 | The role of the amygdala in fear and anxiety. | M Davis | Annu. Rev. Neurosci. | 1992 | 1575447 | No |
| 1438 | 1216 | 1216.0 | 33.64 | 33.6 | On finding all suboptimal foldings of an RNA molecule. | M Zuker | Science | 1989 | 2468181 | No |
| 1439 | 1216 | 1216.0 | 68.01 | 68.0 | The drug abuse screening test. | H A Skinner | Addict Behav | 1982 | 7183189 | Yes |
| 1440 | 1215 | 1215.0 | 43.8 | 43.8 | Multiple imputation: a primer. | J L Schafer | Stat Methods Med Res | 1999 | 10347857 | No |
| 1441 | 1215 | 1215.0 | 0.0 | 0.0 | ENZYMATIC BASIS FOR ACTIVE TRANSPORT OF NA+ AND K+ ACROSS CELL MEMBRANE. | J C SKOU | Physiol. Rev. | 1965 | 14337569 | No |
| 1442 | 1215 | 1215.0 | 42.92 | 42.9 | Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. | Ralph A Defronzo | Diabetes | 2009 | 19336687 | No |
| 1443 | 3644 | 1214.7 | 108.37 | 36.1 | A neural substrate of prediction and reward. | W Schultz, P Dayan, P R Montague | Science | 1997 | 9054347 | No |
| 1444 | 4858 | 1214.5 | 236.75 | 59.2 | 16S ribosomal DNA amplification for phylogenetic study. | W G Weisburg, S M Barns, D A Pelletier, D J Lane | J. Bacteriol. | 1991 | 1987160 | Yes |
| 1445 | 1214 | 1214.0 | 30.53 | 30.5 | Perceptions of epigenetics. | Adrian Bird | Nature | 2007 | 17522671 | Yes |
| 1446 | 1213 | 1213.0 | 0.0 | 0.0 | A simple fluorometric assay for lipoperoxide in blood plasma. | K Yagi | Biochem Med | 1976 | 962904 | Yes |
| 1447 | 2426 | 1213.0 | 95.4 | 47.7 | Separate visual pathways for perception and action. | M A Goodale, A D Milner | Trends Neurosci. | 1992 | 1374953 | No |
| 1448 | 2426 | 1213.0 | 80.86 | 40.4 | Event-related EEG/MEG synchronization and desynchronization: basic principles. | G Pfurtscheller, F H Lopes da Silva | Clin Neurophysiol | 1999 | 10576479 | No |
| 1449 | 9697 | 1212.1 | 284.55 | 35.6 | Electric field effect in atomically thin carbon films. | K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A Firsov | Science | 2004 | 15499015 | Yes |
| 1450 | 2424 | 1212.0 | 60.95 | 30.5 | Fibroblasts in cancer. | Raghu Kalluri, Michael Zeisberg | Nat. Rev. Cancer | 2006 | 16572188 | No |
| 1451 | 2423 | 1211.5 | 50.48 | 25.2 | The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. | Michael H Glickman, Aaron Ciechanover | Physiol. Rev. | 2002 | 11917093 | No |
| 1452 | 1211 | 1211.0 | 35.83 | 35.8 | Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. | Shitij Kapur | Am J Psychiatry | 2003 | 12505794 | No |
| 1453 | 1211 | 1211.0 | 41.46 | 41.5 | Porous scaffold design for tissue engineering. | Scott J Hollister | Nat Mater | 2005 | 16003400 | No |
| 1454 | 1210 | 1210.0 | 40.25 | 40.2 | Molecular dissection of reactive astrogliosis and glial scar formation. | Michael V Sofroniew | Trends Neurosci. | 2009 | 19782411 | No |
| 1455 | 2418 | 1209.0 | 143.77 | 71.9 | phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. | Paul J McMurdie, Susan Holmes | PLoS ONE | 2013 | 23630581 | Yes |
| 1456 | 1208 | 1208.0 | 26.41 | 26.4 | Intrinsically unstructured proteins. | Peter Tompa | Trends Biochem. Sci. | 2002 | 12368089 | No |
| 1457 | 2415 | 1207.5 | 89.39 | 44.7 | Oxidative stress, glutamate, and neurodegenerative disorders. | J T Coyle, P Puttfarcken | Science | 1993 | 7901908 | No |
| 1458 | 3622 | 1207.3 | 1395.48 | 465.2 | Cancer statistics, 2019. | Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal | CA Cancer J Clin | 2019 | 30620402 | Yes |
| 1459 | 1207 | 1207.0 | 0.0 | 0.0 | Separation of leukocytes from blood and bone marrow. Introduction. | A Böyum | Scand. J. Clin. Lab. Invest. Suppl. | 1968 | 5707208 | Yes |
| 1460 | 2414 | 1207.0 | 116.54 | 58.3 | The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. | P F Lovibond, S H Lovibond | Behav Res Ther | 1995 | 7726811 | Yes |
| 1461 | 2414 | 1207.0 | 53.6 | 26.8 | Missing pieces in the NF-kappaB puzzle. | Sankar Ghosh, Michael Karin | Cell | 2002 | 11983155 | No |
| 1462 | 2414 | 1207.0 | 58.53 | 29.3 | Why do cancers have high aerobic glycolysis? | Robert A Gatenby, Robert J Gillies | Nat. Rev. Cancer | 2004 | 15516961 | No |
| 1463 | 1207 | 1207.0 | 33.09 | 33.1 | The retinal pigment epithelium in visual function. | Olaf Strauss | Physiol. Rev. | 2005 | 15987797 | No |
| 1464 | 3619 | 1206.3 | 158.07 | 52.7 | A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. | J R Le Gall, S Lemeshow, F Saulnier | JAMA | 1993 | 8254858 | Yes |
| 1465 | 2412 | 1206.0 | 72.55 | 36.3 | Quantum dot bioconjugates for ultrasensitive nonisotopic detection. | W C Chan, S Nie | Science | 1998 | 9748158 | Yes |
| 1466 | 1206 | 1206.0 | 28.37 | 28.4 | Oxidative stress shortens telomeres. | Thomas von Zglinicki | Trends Biochem. Sci. | 2002 | 12114022 | Yes |
| 1467 | 1206 | 1206.0 | 0.0 | 0.0 | Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. | E G GRAY | J. Anat. | 1959 | 13829103 | Yes |
| 1468 | 1206 | 1206.0 | 26.47 | 26.5 | RNA silencing in plants. | David Baulcombe | Nature | 2004 | 15372043 | No |
| 1469 | 1206 | 1206.0 | 34.68 | 34.7 | Tricine-SDS-PAGE. | Hermann Schägger | Nat Protoc | 2006 | 17406207 | Yes |
| 1470 | 4823 | 1205.8 | 135.5 | 33.9 | Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. | C A Lipinski, F Lombardo, B W Dominy, P J Feeney | Adv. Drug Deliv. Rev. | 2001 | 11259830 | No |
| 1471 | 7235 | 1205.8 | 262.65 | 43.8 | Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. | Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E Walters | Arch. Gen. Psychiatry | 2005 | 15939837 | Yes |
| 1472 | 1205 | 1205.0 | 0.0 | 0.0 | Why genes in pieces? | W Gilbert | Nature | 1978 | 622185 | Yes |
| 1473 | 3615 | 1205.0 | 119.94 | 40.0 | Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. | M Hasegawa, H Kishino, T Yano | J. Mol. Evol. | 1985 | 3934395 | Yes |
| 1474 | 1205 | 1205.0 | 0.0 | 0.0 | Influences of glucose loading and of injected insulin on hepatic glucose output. | R STEELE | Ann. N. Y. Acad. Sci. | 1959 | 13833973 | Yes |
| 1475 | 1204 | 1204.0 | 29.41 | 29.4 | How eukaryotic transcriptional activators work. | M Ptashne | Nature | 1988 | 3050531 | No |
| 1476 | 2406 | 1203.0 | 76.19 | 38.1 | Building better batteries. | M Armand, J-M Tarascon | Nature | 2008 | 18256660 | No |
| 1477 | 1202 | 1202.0 | 75.77 | 75.8 | Measurement of health state utilities for economic appraisal. | G W Torrance | J Health Econ | 1986 | 10311607 | No |
| 1478 | 1201 | 1201.0 | 0.0 | 0.0 | The genetical evolution of social behaviour. II. | W D Hamilton | J. Theor. Biol. | 1964 | 5875340 | Yes |
| 1479 | 1201 | 1201.0 | 23.39 | 23.4 | Histone acetylation and transcriptional regulatory mechanisms. | K Struhl | Genes Dev. | 1998 | 9499396 | No |
| 1480 | 2402 | 1201.0 | 0.0 | 0.0 | A "DIRECT-COLORING" THIOCHOLINE METHOD FOR CHOLINESTERASES. | M J KARNOVSKY, L ROOTS | J. Histochem. Cytochem. | 1964 | 14187330 | Yes |
| 1481 | 1200 | 1200.0 | 31.41 | 31.4 | Far-field optical nanoscopy. | Stefan W Hell | Science | 2007 | 17525330 | No |
| 1482 | 3599 | 1199.7 | 0.0 | 0.0 | Impact of Event Scale: a measure of subjective stress. | M Horowitz, N Wilner, W Alvarez | Psychosom Med | 1979 | 472086 | Yes |
| 1483 | 1199 | 1199.0 | 0.0 | 0.0 | Impulses and Physiological States in Theoretical Models of Nerve Membrane. | R Fitzhugh | Biophys. J. | 1961 | 19431309 | Yes |
| 1484 | 1199 | 1199.0 | 31.34 | 31.3 | The hippo signaling pathway in development and cancer. | Duojia Pan | Dev. Cell | 2010 | 20951342 | No |
| 1485 | 2397 | 1198.5 | 51.1 | 25.6 | The evolutionary fate and consequences of duplicate genes. | M Lynch, J S Conery | Science | 2000 | 11073452 | No |
| 1486 | 2397 | 1198.5 | 64.86 | 32.4 | Shared principles in NF-kappaB signaling. | Matthew S Hayden, Sankar Ghosh | Cell | 2008 | 18267068 | No |
| 1487 | 1198 | 1198.0 | 27.54 | 27.5 | Regulatory T cells, tumour immunity and immunotherapy. | Weiping Zou | Nat. Rev. Immunol. | 2006 | 16557261 | No |
| 1488 | 1198 | 1198.0 | 0.0 | 0.0 | THE ESTIMATION OF PEPSIN, TRYPSIN, PAPAIN, AND CATHEPSIN WITH HEMOGLOBIN. | M L Anson | J. Gen. Physiol. | 1938 | 19873094 | Yes |
| 1489 | 1197 | 1197.0 | 0.0 | 0.0 | Chromatin structure: a repeating unit of histones and DNA. | R D Kornberg | Science | 1974 | 4825889 | Yes |
| 1490 | 1197 | 1197.0 | 51.0 | 51.0 | Number of people with glaucoma worldwide. | H A Quigley | Br J Ophthalmol | 1996 | 8695555 | No |
| 1491 | 1196 | 1196.0 | 0.0 | 0.0 | TRANSFORMATION OF BIOCHEMICALLY DEFICIENT STRAINS OF BACILLUS SUBTILIS BY DEOXYRIBONUCLEATE. | J Spizizen | Proc. Natl. Acad. Sci. U.S.A. | 1958 | 16590310 | Yes |
| 1492 | 4781 | 1195.2 | 156.42 | 39.1 | Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. | B Biswal, F Z Yetkin, V M Haughton, J S Hyde | Magn Reson Med | 1995 | 8524021 | Yes |
| 1493 | 1195 | 1195.0 | 34.08 | 34.1 | Insulin and insulin-like growth factor signalling in neoplasia. | Michael Pollak | Nat. Rev. Cancer | 2008 | 19029956 | No |
| 1494 | 2389 | 1194.5 | 93.05 | 46.5 | Unified approach for molecular dynamics and density-functional theory. | Car, Parrinello | Phys. Rev. Lett. | 1985 | 10032153 | Yes |
| 1495 | 1194 | 1194.0 | 0.0 | 0.0 | Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. | K O Fagerström | Addict Behav | 1978 | 735910 | Yes |
| 1496 | 1194 | 1194.0 | 46.71 | 46.7 | The biology of interleukin-6. | T Kishimoto | Blood | 1989 | 2473791 | No |
| 1497 | 2388 | 1194.0 | 57.27 | 28.6 | Coordination of circadian timing in mammals. | Steven M Reppert, David R Weaver | Nature | 2002 | 12198538 | No |
| 1498 | 2388 | 1194.0 | 65.62 | 32.8 | The human plasma proteome: history, character, and diagnostic prospects. | N Leigh Anderson, Norman G Anderson | Mol. Cell Proteomics | 2002 | 12488461 | No |
| 1499 | 1193 | 1193.0 | 28.75 | 28.8 | Neurotrophins as synaptic modulators. | M M Poo | Nat. Rev. Neurosci. | 2001 | 11253356 | No |
| 1500 | 1192 | 1192.0 | 50.84 | 50.8 | Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. | H J Gundersen | J Microsc | 1986 | 3761363 | Yes |
| 1501 | 1191 | 1191.0 | 29.52 | 29.5 | A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. | Dale R Nyholt | Am. J. Hum. Genet. | 2004 | 14997420 | Yes |
| 1502 | 1191 | 1191.0 | 40.53 | 40.5 | Accurate Coulomb-fitting basis sets for H to Rn. | Florian Weigend | Phys Chem Chem Phys | 2006 | 16633586 | Yes |
| 1503 | 5952 | 1190.4 | 133.97 | 26.8 | Prospective identification of tumorigenic breast cancer cells. | Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F Clarke | Proc. Natl. Acad. Sci. U.S.A. | 2003 | 12629218 | Yes |
| 1504 | 1190 | 1190.0 | 24.37 | 24.4 | Aggresomes, inclusion bodies and protein aggregation. | R R Kopito | Trends Cell Biol. | 2000 | 11121744 | No |
| 1505 | 1189 | 1189.0 | 38.32 | 38.3 | The world health report 2002 - reducing risks, promoting healthy life. | J J Guilbert | Educ Health (Abingdon) | 2003 | 14741909 | Yes |
| 1506 | 1189 | 1189.0 | 27.36 | 27.4 | The Buccaneer software for automated model building. 1. Tracing protein chains. | Kevin Cowtan | Acta Crystallogr. D Biol. Crystallogr. | 2006 | 16929101 | Yes |
| 1507 | 4755 | 1188.8 | 0.0 | 0.0 | Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. | E A Jaffe, R L Nachman, C G Becker, C R Minick | J. Clin. Invest. | 1973 | 4355998 | Yes |
| 1508 | 1188 | 1188.0 | 0.0 | 0.0 | Which elements are excited in electrical stimulation of mammalian central nervous system: a review. | J B Ranck | Brain Res. | 1975 | 1102064 | No |
| 1509 | 3564 | 1188.0 | 132.06 | 44.0 | Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. | P A Wolf, R D Abbott, W B Kannel | Stroke | 1991 | 1866765 | Yes |
| 1510 | 2376 | 1188.0 | 82.12 | 41.1 | Nonparametric statistical testing of EEG- and MEG-data. | Eric Maris, Robert Oostenveld | J. Neurosci. Methods | 2007 | 17517438 | Yes |
| 1511 | 2374 | 1187.0 | 81.48 | 40.7 | A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. | S Tabor, C C Richardson | Proc. Natl. Acad. Sci. U.S.A. | 1985 | 3156376 | Yes |
| 1512 | 1187 | 1187.0 | 26.39 | 26.4 | Immunosuppressive networks in the tumour environment and their therapeutic relevance. | Weiping Zou | Nat. Rev. Cancer | 2005 | 15776005 | No |
| 1513 | 2373 | 1186.5 | 152.55 | 76.3 | Interrater reliability of a modified Ashworth scale of muscle spasticity. | R W Bohannon, M B Smith | Phys Ther | 1987 | 3809245 | Yes |
| 1514 | 1186 | 1186.0 | 39.7 | 39.7 | The pathophysiology of tumor necrosis factors. | P Vassalli | Annu. Rev. Immunol. | 1992 | 1590993 | No |
| 1515 | 1185 | 1185.0 | 0.0 | 0.0 | Simple memory: a theory for archicortex. | D Marr | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | 1971 | 4399412 | Yes |
| 1516 | 3551 | 1183.7 | 88.83 | 29.6 | NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. | S Ghosh, M J May, E B Kopp | Annu. Rev. Immunol. | 1998 | 9597130 | No |
| 1517 | 2367 | 1183.5 | 122.32 | 61.2 | Avoiding false positives with PCR. | S Kwok, R Higuchi | Nature | 1989 | 2716852 | Yes |
| 1518 | 1183 | 1183.0 | 50.29 | 50.3 | The crisis in antibiotic resistance. | H C Neu | Science | 1992 | 1509257 | No |
| 1519 | 1183 | 1183.0 | 41.92 | 41.9 | A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. | P J Goodford | J. Med. Chem. | 1985 | 3892003 | Yes |
| 1520 | 2365 | 1182.5 | 63.16 | 31.6 | The DNA-damage response in human biology and disease. | Stephen P Jackson, Jiri Bartek | Nature | 2009 | 19847258 | No |
| 1521 | 1182 | 1182.0 | 42.91 | 42.9 | Interleukin-6: an overview. | J Van Snick | Annu. Rev. Immunol. | 1990 | 2188664 | No |
| 1522 | 1180 | 1180.0 | 61.89 | 61.9 | Responses to depression and their effects on the duration of depressive episodes. | S Nolen-Hoeksema | J Abnorm Psychol | 1991 | 1757671 | No |
| 1523 | 3538 | 1179.3 | 132.81 | 44.3 | FastTree 2--approximately maximum-likelihood trees for large alignments. | Morgan N Price, Paramvir S Dehal, Adam P Arkin | PLoS ONE | 2010 | 20224823 | Yes |
| 1524 | 1179 | 1179.0 | 0.0 | 0.0 | Ionic blockage of sodium channels in nerve. | A M Woodhull | J. Gen. Physiol. | 1973 | 4541078 | Yes |
| 1525 | 1179 | 1179.0 | 65.5 | 65.5 | Cell damage in the brain: a speculative synthesis. | B K Siesjö | J. Cereb. Blood Flow Metab. | 1981 | 6276420 | No |
| 1526 | 1179 | 1179.0 | 45.39 | 45.4 | Gold-catalyzed organic reactions. | A Stephen K Hashmi | Chem. Rev. | 2007 | 17580975 | Yes |
| 1527 | 1178 | 1178.0 | 0.0 | 0.0 | Amino acid difference formula to help explain protein evolution. | R Grantham | Science | 1974 | 4843792 | Yes |
| 1528 | 3534 | 1178.0 | 85.44 | 28.5 | Toll-like receptors. | Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira | Annu. Rev. Immunol. | 2003 | 12524386 | No |
| 1529 | 1177 | 1177.0 | 0.0 | 0.0 | Paced auditory serial-addition task: a measure of recovery from concussion. | D M Gronwall | Percept Mot Skills | 1977 | 866038 | Yes |
| 1530 | 1177 | 1177.0 | 35.35 | 35.4 | Stress and hippocampal plasticity. | B S McEwen | Annu. Rev. Neurosci. | 1999 | 10202533 | No |
| 1531 | 1177 | 1177.0 | 32.75 | 32.8 | The mitochondrial permeability transition pore and its role in cell death. | M Crompton | Biochem. J. | 1999 | 10393078 | No |
| 1532 | 2354 | 1177.0 | 98.28 | 49.1 | Macrophage plasticity and polarization: in vivo veritas. | Antonio Sica, Alberto Mantovani | J. Clin. Invest. | 2012 | 22378047 | No |
| 1533 | 2353 | 1176.5 | 104.49 | 52.2 | Role of free radicals and catalytic metal ions in human disease: an overview. | B Halliwell, J M Gutteridge | Meth. Enzymol. | 1990 | 2172697 | No |
| 1534 | 1176 | 1176.0 | 0.0 | 0.0 | Fluorescence energy transfer as a spectroscopic ruler. | L Stryer | Annu. Rev. Biochem. | 1978 | 354506 | No |
| 1535 | 1176 | 1176.0 | 33.6 | 33.6 | The proto-oncogene Bcl-2 and its role in regulating apoptosis. | G Kroemer | Nat. Med. | 1997 | 9176486 | No |
| 1536 | 2352 | 1176.0 | 67.23 | 33.6 | Adipose tissue as an endocrine organ. | Erin E Kershaw, Jeffrey S Flier | J. Clin. Endocrinol. Metab. | 2004 | 15181022 | No |
| 1537 | 2351 | 1175.5 | 55.9 | 27.9 | Chemokines: a new classification system and their role in immunity. | A Zlotnik, O Yoshie | Immunity | 2000 | 10714678 | No |
| 1538 | 1175 | 1175.0 | 42.02 | 42.0 | The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. | R R Llinás | Science | 1988 | 3059497 | No |
| 1539 | 1175 | 1175.0 | 47.05 | 47.0 | The stress response in fish. | S E Wendelaar Bonga | Physiol. Rev. | 1997 | 9234959 | No |
| 1540 | 1175 | 1175.0 | 35.48 | 35.5 | Network pharmacology: the next paradigm in drug discovery. | Andrew L Hopkins | Nat. Chem. Biol. | 2008 | 18936753 | No |
| 1541 | 1174 | 1174.0 | 47.13 | 47.1 | Extracellular ATP: effects, sources and fate. | J L Gordon | Biochem. J. | 1986 | 3006665 | No |
| 1542 | 1174 | 1174.0 | 32.88 | 32.9 | In vivo near-infrared fluorescence imaging. | John V Frangioni | Curr Opin Chem Biol | 2003 | 14580568 | No |
| 1543 | 3519 | 1173.0 | 101.34 | 33.8 | Two-photon laser scanning fluorescence microscopy. | W Denk, J H Strickler, W W Webb | Science | 1990 | 2321027 | Yes |
| 1544 | 2346 | 1173.0 | 62.08 | 31.0 | A comparison of bayesian methods for haplotype reconstruction from population genotype data. | Matthew Stephens, Peter Donnelly | Am. J. Hum. Genet. | 2003 | 14574645 | Yes |
| 1545 | 1172 | 1172.0 | 38.39 | 38.4 | Alpha-crystallin can function as a molecular chaperone. | J Horwitz | Proc. Natl. Acad. Sci. U.S.A. | 1992 | 1438232 | Yes |
| 1546 | 2344 | 1172.0 | 59.27 | 29.6 | Issues and challenges facing rechargeable lithium batteries. | J M Tarascon, M Armand | Nature | 2001 | 11713543 | Yes |
| 1547 | 1172 | 1172.0 | 0.0 | 0.0 | The influence of some cations on an adenosine triphosphatase from peripheral nerves. | J C SKOU | Biochim. Biophys. Acta | 1957 | 13412736 | Yes |
| 1548 | 1172 | 1172.0 | 32.16 | 32.2 | Neurovascular regulation in the normal brain and in Alzheimer's disease. | Costantino Iadecola | Nat. Rev. Neurosci. | 2004 | 15100718 | No |
| 1549 | 4688 | 1172.0 | 134.12 | 33.5 | Improved prediction of signal peptides: SignalP 3.0. | Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren Brunak | J. Mol. Biol. | 2004 | 15223320 | Yes |
| 1550 | 2342 | 1171.0 | 0.0 | 0.0 | Variations in the pattern of pubertal changes in boys. | W A Marshall, J M Tanner | Arch. Dis. Child. | 1970 | 5440182 | Yes |
| 1551 | 1171 | 1171.0 | 39.44 | 39.4 | Oxidative stress: oxidants and antioxidants. | H Sies | Exp. Physiol. | 1997 | 9129943 | No |
| 1552 | 1171 | 1171.0 | 30.42 | 30.4 | Introduction to NF-kappaB: players, pathways, perspectives. | T D Gilmore | Oncogene | 2006 | 17072321 | No |
| 1553 | 1170 | 1170.0 | 31.25 | 31.2 | Five rules for the evolution of cooperation. | Martin A Nowak | Science | 2006 | 17158317 | No |
| 1554 | 1169 | 1169.0 | 32.08 | 32.1 | Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. | S C Manolagas | Endocr. Rev. | 2000 | 10782361 | No |
| 1555 | 1169 | 1169.0 | 37.17 | 37.2 | Task switching. | Stephen Monsell | Trends Cogn. Sci. (Regul. Ed.) | 2003 | 12639695 | Yes |
| 1556 | 3505 | 1168.3 | 266.43 | 88.8 | Deep learning. | Yann LeCun, Yoshua Bengio, Geoffrey Hinton | Nature | 2015 | 26017442 | No |
| 1557 | 1168 | 1168.0 | 48.27 | 48.3 | Cellular defenses against damage from reactive oxygen species. | B P Yu | Physiol. Rev. | 1994 | 8295932 | No |
| 1558 | 1168 | 1168.0 | 27.44 | 27.4 | Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. | R K Jain | Nat. Med. | 2001 | 11533692 | No |
| 1559 | 1167 | 1167.0 | 43.47 | 43.5 | Ionic dependence of glutamate neurotoxicity. | D W Choi | J. Neurosci. | 1987 | 2880938 | Yes |
| 1560 | 1167 | 1167.0 | 32.29 | 32.3 | A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. | D A Gewirtz | Biochem. Pharmacol. | 1999 | 10075079 | No |
| 1561 | 1167 | 1167.0 | 24.98 | 25.0 | Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. | D I Svergun | Biophys. J. | 1999 | 10354416 | Yes |
| 1562 | 4664 | 1166.0 | 246.56 | 61.6 | An inventory for measuring clinical anxiety: psychometric properties. | A T Beck, N Epstein, G Brown, R A Steer | J Consult Clin Psychol | 1988 | 3204199 | Yes |
| 1563 | 1166 | 1166.0 | 56.25 | 56.2 | Simple proton spectroscopic imaging. | W T Dixon | Radiology | 1984 | 6089263 | Yes |
| 1564 | 1165 | 1165.0 | 0.0 | 0.0 | The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. | R Ross | J. Cell Biol. | 1971 | 4327464 | Yes |
| 1565 | 1165 | 1165.0 | 40.68 | 40.7 | Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. | P A Bradford | Clin. Microbiol. Rev. | 2001 | 11585791 | No |
| 1566 | 3495 | 1165.0 | 85.51 | 28.5 | TOR signaling in growth and metabolism. | Stephan Wullschleger, Robbie Loewith, Michael N Hall | Cell | 2006 | 16469695 | No |
| 1567 | 1165 | 1165.0 | 39.35 | 39.4 | n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. | Philip C Calder | Am. J. Clin. Nutr. | 2006 | 16841861 | No |
| 1568 | 8153 | 1164.7 | 192.06 | 27.4 | Embryonic stem cell lines derived from human blastocysts. | J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M Jones | Science | 1998 | 9804556 | Yes |
| 1569 | 2329 | 1164.5 | 105.41 | 52.7 | The biofilm matrix. | Hans-Curt Flemming, Jost Wingender | Nat. Rev. Microbiol. | 2010 | 20676145 | No |
| 1570 | 2328 | 1164.0 | 62.05 | 31.0 | How matrix metalloproteinases regulate cell behavior. | M D Sternlicht, Z Werb | Annu. Rev. Cell Dev. Biol. | 2001 | 11687497 | No |
| 1571 | 3491 | 1163.7 | 104.27 | 34.8 | The rapid generation of mutation data matrices from protein sequences. | D T Jones, W R Taylor, J M Thornton | Comput. Appl. Biosci. | 1992 | 1633570 | Yes |
| 1572 | 2327 | 1163.5 | 54.92 | 27.5 | The Bcl2 family: regulators of the cellular life-or-death switch. | Suzanne Cory, Jerry M Adams | Nat. Rev. Cancer | 2002 | 12209154 | No |
| 1573 | 1163 | 1163.0 | 58.78 | 58.8 | Modeling and variable selection in epidemiologic analysis. | S Greenland | Am J Public Health | 1989 | 2916724 | Yes |
| 1574 | 1163 | 1163.0 | 42.63 | 42.6 | Glycobiology: Toward Understanding the Function of Sugars. | Raymond A. Dwek | Chem. Rev. | 1996 | 11848770 | Yes |
| 1575 | 1163 | 1163.0 | 34.78 | 34.8 | Use and misuse of the receiver operating characteristic curve in risk prediction. | Nancy R Cook | Circulation | 2007 | 17309939 | Yes |
| 1576 | 2324 | 1162.0 | 87.86 | 43.9 | Prediction of protein antigenic determinants from amino acid sequences. | T P Hopp, K R Woods | Proc. Natl. Acad. Sci. U.S.A. | 1981 | 6167991 | Yes |
| 1577 | 2324 | 1162.0 | 88.19 | 44.1 | A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. | J Messing, J Vieira | Gene | 1982 | 6295880 | Yes |
| 1578 | 1162 | 1162.0 | 40.1 | 40.1 | Leishmaniasis: current situation and new perspectives. | P Desjeux | Comp. Immunol. Microbiol. Infect. Dis. | 2004 | 15225981 | No |
| 1579 | 1161 | 1161.0 | 33.09 | 33.1 | Origin, biogenesis, and activity of plant microRNAs. | Olivier Voinnet | Cell | 2009 | 19239888 | No |
| 1580 | 2320 | 1160.0 | 0.0 | 0.0 | Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. | D H Figurski, D R Helinski | Proc. Natl. Acad. Sci. U.S.A. | 1979 | 377280 | Yes |
| 1581 | 1160 | 1160.0 | 56.49 | 56.5 | Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. | Virginia A Moyer | Ann. Intern. Med. | 2012 | 22801674 | No |
| 1582 | 4639 | 1159.8 | 0.0 | 0.0 | The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. | S P Baker, B O'Neill, W Haddon, W B Long | J Trauma | 1974 | 4814394 | Yes |
| 1583 | 1159 | 1159.0 | 0.0 | 0.0 | Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. | J M VAN ROSSUM | Arch Int Pharmacodyn Ther | 1963 | 13996119 | Yes |
| 1584 | 2318 | 1159.0 | 78.69 | 39.3 | Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. | B R Celli, W MacNee | Eur. Respir. J. | 2004 | 15219010 | No |
| 1585 | 3474 | 1158.0 | 0.0 | 0.0 | Research diagnostic criteria: rationale and reliability. | R L Spitzer, J Endicott, E Robins | Arch. Gen. Psychiatry | 1978 | 655775 | Yes |
| 1586 | 1158 | 1158.0 | 36.8 | 36.8 | Molecular biology of prion diseases. | S B Prusiner | Science | 1991 | 1675487 | No |
| 1587 | 2316 | 1158.0 | 107.28 | 53.6 | The transtheoretical model of health behavior change. | J O Prochaska, W F Velicer | Am J Health Promot | 1997 | 10170434 | No |
| 1588 | 1158 | 1158.0 | 31.97 | 32.0 | Python: a programming language for software integration and development. | M F Sanner | J. Mol. Graph. Model. | 1999 | 10660911 | Yes |
| 1589 | 1158 | 1158.0 | 27.91 | 27.9 | Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. | S S Ferguson | Pharmacol. Rev. | 2001 | 11171937 | No |
| 1590 | 2315 | 1157.5 | 77.44 | 38.7 | The precuneus: a review of its functional anatomy and behavioural correlates. | Andrea E Cavanna, Michael R Trimble | Brain | 2006 | 16399806 | No |
| 1591 | 1157 | 1157.0 | 0.0 | 0.0 | The inverse care law. | J T Hart | Lancet | 1971 | 4100731 | Yes |
| 1592 | 4625 | 1156.2 | 115.69 | 28.9 | Probability-based protein identification by searching sequence databases using mass spectrometry data. | D N Perkins, D J Pappin, D M Creasy, J S Cottrell | Electrophoresis | 1999 | 10612281 | Yes |
| 1593 | 1156 | 1156.0 | 47.76 | 47.8 | History of the Rochester Epidemiology Project. | L J Melton | Mayo Clin. Proc. | 1996 | 8594285 | No |
| 1594 | 1156 | 1156.0 | 28.54 | 28.5 | Cancer epigenomics: DNA methylomes and histone-modification maps. | Manel Esteller | Nat. Rev. Genet. | 2007 | 17339880 | No |
| 1595 | 15026 | 1155.8 | 471.54 | 36.3 | Clustal W and Clustal X version 2.0. | M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G Higgins | Bioinformatics | 2007 | 17846036 | Yes |
| 1596 | 3466 | 1155.3 | 94.87 | 31.6 | Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. | Daniel Falush, Matthew Stephens, Jonathan K Pritchard | Genetics | 2003 | 12930761 | Yes |
| 1597 | 1155 | 1155.0 | 79.31 | 79.3 | Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. | F E Zajac | Crit Rev Biomed Eng | 1989 | 2676342 | No |
| 1598 | 1155 | 1155.0 | 0.0 | 0.0 | METHOD FOR ASSAY OF INTESTINAL DISACCHARIDASES. | A DAHLQVIST | Anal. Biochem. | 1964 | 14106916 | Yes |
| 1599 | 2309 | 1154.5 | 87.27 | 43.6 | Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. | M Karas, F Hillenkamp | Anal. Chem. | 1988 | 3239801 | Yes |
| 1600 | 1154 | 1154.0 | 31.57 | 31.6 | PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. | B M Spiegelman | Diabetes | 1998 | 9568680 | No |
| 1601 | 2308 | 1154.0 | 87.32 | 43.7 | Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. | Stephen M Smith, Thomas E Nichols | Neuroimage | 2009 | 18501637 | Yes |
| 1602 | 1153 | 1153.0 | 38.13 | 38.1 | Determination of minimum inhibitory concentrations. | J M Andrews | J. Antimicrob. Chemother. | 2001 | 11420333 | Yes |
| 1603 | 1152 | 1152.0 | 40.69 | 40.7 | DNA topoisomerases. | J C Wang | Annu. Rev. Biochem. | 1985 | 2992360 | No |
| 1604 | 1152 | 1152.0 | 0.0 | 0.0 | Dynamic properties of mammalian skeletal muscles. | R I Close | Physiol. Rev. | 1972 | 4256989 | No |
| 1605 | 2304 | 1152.0 | 92.49 | 46.2 | A rapid boiling method for the preparation of bacterial plasmids. | D S Holmes, M Quigley | Anal. Biochem. | 1981 | 6269464 | Yes |
| 1606 | 2304 | 1152.0 | 118.52 | 59.3 | Assays of glutathione peroxidase. | L Flohé, W A Günzler | Meth. Enzymol. | 1984 | 6727659 | Yes |
| 1607 | 1152 | 1152.0 | 29.48 | 29.5 | Mechanisms of bone metastasis. | G David Roodman | N. Engl. J. Med. | 2004 | 15084698 | No |
| 1608 | 1151 | 1151.0 | 38.11 | 38.1 | Trophic factors and neuronal survival. | Y A Barde | Neuron | 1989 | 2697237 | No |
| 1609 | 1151 | 1151.0 | 29.32 | 29.3 | Tumor metastasis: mechanistic insights and clinical challenges. | Patricia S Steeg | Nat. Med. | 2006 | 16892035 | No |
| 1610 | 2301 | 1150.5 | 87.75 | 43.9 | Molecular mechanisms and clinical applications of angiogenesis. | Peter Carmeliet, Rakesh K Jain | Nature | 2011 | 21593862 | No |
| 1611 | 5745 | 1149.0 | 156.91 | 31.4 | Site-directed mutagenesis by overlap extension using the polymerase chain reaction. | S N Ho, H D Hunt, R M Horton, J K Pullen, L R Pease | Gene | 1989 | 2744487 | Yes |
| 1612 | 1149 | 1149.0 | 23.57 | 23.6 | Ubiquitin-dependent protein degradation. | M Hochstrasser | Annu. Rev. Genet. | 1996 | 8982460 | No |
| 1613 | 3445 | 1148.3 | 0.0 | 0.0 | A rapid method for the isolation of functional thymus-derived murine lymphocytes. | M H Julius, E Simpson, L A Herzenberg | Eur. J. Immunol. | 1973 | 4587740 | Yes |
| 1614 | 2294 | 1147.0 | 89.6 | 44.8 | Performing the exact test of Hardy-Weinberg proportion for multiple alleles. | S W Guo, E A Thompson | Biometrics | 1992 | 1637966 | Yes |
| 1615 | 2294 | 1147.0 | 60.0 | 30.0 | Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. | T Miyashita, J C Reed | Cell | 1995 | 7834749 | Yes |
| 1616 | 1146 | 1146.0 | 45.84 | 45.8 | Validation of a decisional conflict scale. | A M O'Connor | Med Decis Making | 1995 | 7898294 | Yes |
| 1617 | 1146 | 1146.0 | 30.19 | 30.2 | The molecular logic of endocannabinoid signalling. | Daniele Piomelli | Nat. Rev. Neurosci. | 2003 | 14595399 | No |
| 1618 | 1145 | 1145.0 | 27.13 | 27.1 | The ubiquitin-proteasome proteolytic pathway. | A Ciechanover | Cell | 1994 | 7923371 | No |
| 1619 | 1145 | 1145.0 | 44.89 | 44.9 | Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? | George A Bonanno | Am Psychol | 2004 | 14736317 | No |
| 1620 | 3435 | 1145.0 | 111.76 | 37.3 | Optimization by simulated annealing. | S Kirkpatrick, C D Gelatt, M P Vecchi | Science | 1983 | 17813860 | Yes |
| 1621 | 2290 | 1145.0 | 96.95 | 48.5 | Neurocircuitry of addiction. | George F Koob, Nora D Volkow | Neuropsychopharmacology | 2010 | 19710631 | No |
| 1622 | 2289 | 1144.5 | 53.41 | 26.7 | New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. | R D Gietz, A Sugino | Gene | 1988 | 3073106 | Yes |
| 1623 | 1144 | 1144.0 | 45.29 | 45.3 | The atom economy--a search for synthetic efficiency. | B M Trost | Science | 1991 | 1962206 | Yes |
| 1624 | 6863 | 1143.8 | 319.3 | 53.2 | Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. | L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R Tannenbaum | Anal. Biochem. | 1982 | 7181105 | Yes |
| 1625 | 1143 | 1143.0 | 0.0 | 0.0 | Synaptic density in human frontal cortex - developmental changes and effects of aging. | P R Huttenlocher | Brain Res. | 1979 | 427544 | Yes |
| 1626 | 1143 | 1143.0 | 51.83 | 51.8 | The case-crossover design: a method for studying transient effects on the risk of acute events. | M Maclure | Am. J. Epidemiol. | 1991 | 1985444 | Yes |
| 1627 | 2285 | 1142.5 | 63.45 | 31.7 | Multipoint quantitative-trait linkage analysis in general pedigrees. | L Almasy, J Blangero | Am. J. Hum. Genet. | 1998 | 9545414 | Yes |
| 1628 | 2285 | 1142.5 | 61.12 | 30.6 | The incidence of congenital heart disease. | Julien I E Hoffman, Samuel Kaplan | J. Am. Coll. Cardiol. | 2002 | 12084585 | No |
| 1629 | 1142 | 1142.0 | 64.04 | 64.0 | Neurogenetic adaptive mechanisms in alcoholism. | C R Cloninger | Science | 1987 | 2882604 | Yes |
| 1630 | 2284 | 1142.0 | 75.57 | 37.8 | An information-maximization approach to blind separation and blind deconvolution. | A J Bell, T J Sejnowski | Neural Comput | 1995 | 7584893 | Yes |
| 1631 | 2283 | 1141.5 | 57.22 | 28.6 | Inhibitors of mammalian G1 cyclin-dependent kinases. | C J Sherr, J M Roberts | Genes Dev. | 1995 | 7758941 | No |
| 1632 | 1141 | 1141.0 | 0.0 | 0.0 | Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. | A F Habeeb | Anal. Biochem. | 1966 | 4161471 | Yes |
| 1633 | 4564 | 1141.0 | 221.85 | 55.5 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | J Clin Epidemiol | 2009 | 19631508 | No |
| 1634 | 4563 | 1140.8 | 0.0 | 0.0 | Antibiotic susceptibility testing by a standardized single disk method. | A W Bauer, W M Kirby, J C Sherris, M Turck | Am. J. Clin. Pathol. | 1966 | 5325707 | Yes |
| 1635 | 2279 | 1139.5 | 62.03 | 31.0 | A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. | L Buck, R Axel | Cell | 1991 | 1840504 | Yes |
| 1636 | 1139 | 1139.0 | 0.0 | 0.0 | Disconnexion syndromes in animals and man. I. | N Geschwind | Brain | 1965 | 5318481 | No |
| 1637 | 1139 | 1139.0 | 22.68 | 22.7 | The DNA methyltransferases of mammals. | T H Bestor | Hum. Mol. Genet. | 2000 | 11005794 | No |
| 1638 | 2278 | 1139.0 | 86.84 | 43.4 | From best evidence to best practice: effective implementation of change in patients' care. | Richard Grol, Jeremy Grimshaw | Lancet | 2003 | 14568747 | No |
| 1639 | 4553 | 1138.2 | 128.53 | 32.1 | The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. | Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten Schwede | Bioinformatics | 2006 | 16301204 | Yes |
| 1640 | 4550 | 1137.5 | 342.3 | 85.6 | Prevalence of childhood and adult obesity in the United States, 2011-2012. | Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M Flegal | JAMA | 2014 | 24570244 | Yes |
| 1641 | 1137 | 1137.0 | 46.49 | 46.5 | Polycystic ovary syndrome. | S Franks | N. Engl. J. Med. | 1995 | 7651477 | No |
| 1642 | 1137 | 1137.0 | 37.63 | 37.6 | Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. | Michael F Holick | Am. J. Clin. Nutr. | 2004 | 15585788 | No |
| 1643 | 1137 | 1137.0 | 46.15 | 46.1 | Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. | Leonardo Pantoni | Lancet Neurol | 2010 | 20610345 | No |
| 1644 | 2270 | 1135.0 | 64.14 | 32.1 | Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. | F Q Schafer, G R Buettner | Free Radic. Biol. Med. | 2001 | 11368918 | No |
| 1645 | 1135 | 1135.0 | 0.0 | 0.0 | Application of a microtechnique to viral serological investigations. | J L SEVER | J. Immunol. | 1962 | 13910995 | Yes |
| 1646 | 2269 | 1134.5 | 56.74 | 28.4 | Neurotrophins: roles in neuronal development and function. | E J Huang, L F Reichardt | Annu. Rev. Neurosci. | 2001 | 11520916 | No |
| 1647 | 2268 | 1134.0 | 94.59 | 47.3 | The efficiency of systematic sampling in stereology and its prediction. | H J Gundersen, E B Jensen | J Microsc | 1987 | 3430576 | Yes |
| 1648 | 1134 | 1134.0 | 0.0 | 0.0 | Interhemispheric differences in the localization of psychological processes in man. | B Milner | Br. Med. Bull. | 1971 | 4937273 | No |
| 1649 | 2268 | 1134.0 | 50.48 | 25.2 | Mutations affecting segment number and polarity in Drosophila. | C Nüsslein-Volhard, E Wieschaus | Nature | 1980 | 6776413 | Yes |
| 1650 | 1134 | 1134.0 | 30.79 | 30.8 | Neuronal synchrony: a versatile code for the definition of relations? | W Singer | Neuron | 1999 | 10677026 | No |
| 1651 | 1134 | 1134.0 | 24.32 | 24.3 | Epithelial-mesenchymal transitions in development and pathologies. | Jean Paul Thiery | Curr. Opin. Cell Biol. | 2003 | 14644200 | No |
| 1652 | 2268 | 1134.0 | 79.3 | 39.6 | miRBase: integrating microRNA annotation and deep-sequencing data. | Ana Kozomara, Sam Griffiths-Jones | Nucleic Acids Res. | 2011 | 21037258 | Yes |
| 1653 | 2267 | 1133.5 | 0.0 | 0.0 | The structure of coping. | L I Pearlin, C Schooler | J Health Soc Behav | 1978 | 649936 | Yes |
| 1654 | 2267 | 1133.5 | 0.0 | 0.0 | Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. | M Grunstein, D S Hogness | Proc. Natl. Acad. Sci. U.S.A. | 1975 | 1105573 | Yes |
| 1655 | 2267 | 1133.5 | 67.32 | 33.7 | A scaling normalization method for differential expression analysis of RNA-seq data. | Mark D Robinson, Alicia Oshlack | Genome Biol. | 2010 | 20196867 | Yes |
| 1656 | 2266 | 1133.0 | 63.77 | 31.9 | Steatohepatitis: a tale of two "hits"? | C P Day, O F James | Gastroenterology | 1998 | 9547102 | No |
| 1657 | 2266 | 1133.0 | 60.12 | 30.1 | The pathophysiology and treatment of sepsis. | Richard S Hotchkiss, Irene E Karl | N. Engl. J. Med. | 2003 | 12519925 | No |
| 1658 | 1133 | 1133.0 | 40.93 | 40.9 | PsychoPy--Psychophysics software in Python. | Jonathan W Peirce | J. Neurosci. Methods | 2007 | 17254636 | Yes |
| 1659 | 1132 | 1132.0 | 66.37 | 66.4 | The contribution of low birth weight to infant mortality and childhood morbidity. | M C McCormick | N. Engl. J. Med. | 1985 | 3880598 | No |
| 1660 | 3394 | 1131.3 | 107.09 | 35.7 | TCS: a computer program to estimate gene genealogies. | M Clement, D Posada, K A Crandall | Mol. Ecol. | 2000 | 11050560 | Yes |
| 1661 | 1131 | 1131.0 | 25.16 | 25.2 | Altering the genome by homologous recombination. | M R Capecchi | Science | 1989 | 2660260 | No |
| 1662 | 1130 | 1130.0 | 38.76 | 38.8 | Trail Making Test A and B: normative data stratified by age and education. | Tom N Tombaugh | Arch Clin Neuropsychol | 2004 | 15010086 | Yes |
| 1663 | 1129 | 1129.0 | 0.0 | 0.0 | Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. | B Hille | J. Gen. Physiol. | 1977 | 300786 | Yes |
| 1664 | 1129 | 1129.0 | 34.15 | 34.1 | Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. | G von Heijne | J. Mol. Biol. | 1992 | 1593632 | Yes |
| 1665 | 1129 | 1129.0 | 39.66 | 39.7 | DNA topoisomerase poisons as antitumor drugs. | L F Liu | Annu. Rev. Biochem. | 1989 | 2549853 | No |
| 1666 | 1129 | 1129.0 | 26.57 | 26.6 | Stability and flexibility of epigenetic gene regulation in mammalian development. | Wolf Reik | Nature | 2007 | 17522676 | No |
| 1667 | 1128 | 1128.0 | 30.7 | 30.7 | Molecular basis of long-term plasticity underlying addiction. | E J Nestler | Nat. Rev. Neurosci. | 2001 | 11252991 | No |
| 1668 | 2256 | 1128.0 | 84.67 | 42.3 | Alzheimer's disease. | Henry W Querfurth, Frank M LaFerla | N. Engl. J. Med. | 2010 | 20107219 | No |
| 1669 | 2255 | 1127.5 | 66.14 | 33.1 | Malignant gliomas in adults. | Patrick Y Wen, Santosh Kesari | N. Engl. J. Med. | 2008 | 18669428 | No |
| 1670 | 1127 | 1127.0 | 0.0 | 0.0 | Stability of proteins: small globular proteins. | P L Privalov | Adv. Protein Chem. | 1979 | 44431 | No |
| 1671 | 2254 | 1127.0 | 59.25 | 29.6 | An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. | A A Beg, D Baltimore | Science | 1996 | 8864118 | Yes |
| 1672 | 1127 | 1127.0 | 22.51 | 22.5 | Chromatin modification and epigenetic reprogramming in mammalian development. | En Li | Nat. Rev. Genet. | 2002 | 12209141 | No |
| 1673 | 1127 | 1127.0 | 0.0 | 0.0 | Discharge patterns and functional organization of mammalian retina. | S W KUFFLER | J. Neurophysiol. | 1953 | 13035466 | Yes |
| 1674 | 2254 | 1127.0 | 52.27 | 26.1 | Intrinsically unstructured proteins and their functions. | H Jane Dyson, Peter E Wright | Nat. Rev. Mol. Cell Biol. | 2005 | 15738986 | No |
| 1675 | 2253 | 1126.5 | 0.0 | 0.0 | A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. | J E TILL, E A McCULLOCH | Radiat. Res. | 1961 | 13776896 | Yes |
| 1676 | 2252 | 1126.0 | 113.63 | 56.8 | The mini-mental state examination: a comprehensive review. | T N Tombaugh, N J McIntyre | J Am Geriatr Soc | 1992 | 1512391 | No |
| 1677 | 2252 | 1126.0 | 85.28 | 42.6 | Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. | K B Mullis, F A Faloona | Meth. Enzymol. | 1987 | 3431465 | Yes |
| 1678 | 1126 | 1126.0 | 33.42 | 33.4 | The amygdala modulates the consolidation of memories of emotionally arousing experiences. | James L McGaugh | Annu. Rev. Neurosci. | 2004 | 15217324 | No |
| 1679 | 2251 | 1125.5 | 65.31 | 32.7 | Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. | H Cai, D G Harrison | Circ. Res. | 2000 | 11073878 | No |
| 1680 | 2251 | 1125.5 | 64.07 | 32.0 | Unravelling the pathogenesis of inflammatory bowel disease. | R J Xavier, D K Podolsky | Nature | 2007 | 17653185 | No |
| 1681 | 2250 | 1125.0 | 0.0 | 0.0 | Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. | A J Berk, P A Sharp | Cell | 1977 | 922889 | Yes |
| 1682 | 1125 | 1125.0 | 44.37 | 44.4 | Evidence for a central component of post-injury pain hypersensitivity. | C J Woolf | Nature | 1983 | 6656869 | Yes |
| 1683 | 1125 | 1125.0 | 39.8 | 39.8 | Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. | J A Beavo | Physiol. Rev. | 1995 | 7480160 | No |
| 1684 | 2250 | 1125.0 | 66.83 | 33.4 | The biology of vascular endothelial growth factor. | N Ferrara, T Davis-Smyth | Endocr. Rev. | 1997 | 9034784 | No |
| 1685 | 1125 | 1125.0 | 28.78 | 28.8 | Hematopoietic stem-cell transplantation. | Edward A Copelan | N. Engl. J. Med. | 2006 | 16641398 | No |
| 1686 | 1124 | 1124.0 | 35.17 | 35.2 | Steroid receptor regulated transcription of specific genes and gene networks. | K R Yamamoto | Annu. Rev. Genet. | 1985 | 3909942 | No |
| 1687 | 1124 | 1124.0 | 0.0 | 0.0 | The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. | R C Lewontin | Genetics | 1964 | 17248194 | Yes |
| 1688 | 2248 | 1124.0 | 72.05 | 36.0 | Multiple sclerosis. | Alastair Compston, Alasdair Coles | Lancet | 2008 | 18970977 | Yes |
| 1689 | 1123 | 1123.0 | 32.06 | 32.1 | A molecular view of microbial diversity and the biosphere. | N R Pace | Science | 1997 | 9115194 | No |
| 1690 | 2245 | 1122.5 | 59.49 | 29.7 | Lipopolysaccharide endotoxins. | Christian R H Raetz, Chris Whitfield | Annu. Rev. Biochem. | 2002 | 12045108 | No |
| 1691 | 2245 | 1122.5 | 51.93 | 26.0 | Development by self-digestion: molecular mechanisms and biological functions of autophagy. | Beth Levine, Daniel J Klionsky | Dev. Cell | 2004 | 15068787 | No |
| 1692 | 1122 | 1122.0 | 0.0 | 0.0 | Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. | A Fleckenstein | Annu. Rev. Pharmacol. Toxicol. | 1977 | 326161 | No |
| 1693 | 1122 | 1122.0 | 37.6 | 37.6 | Capacitative calcium entry revisited. | J W Putney | Cell Calcium | 1990 | 1965707 | No |
| 1694 | 1121 | 1121.0 | 43.76 | 43.8 | Gene flow and the geographic structure of natural populations. | M Slatkin | Science | 1987 | 3576198 | Yes |
| 1695 | 1121 | 1121.0 | 72.35 | 72.3 | The structure and properties of the sense of coherence scale. | A Antonovsky | Soc Sci Med | 1993 | 8480217 | Yes |
| 1696 | 1121 | 1121.0 | 42.53 | 42.5 | Strong localization of photons in certain disordered dielectric superlattices. | John | Phys. Rev. Lett. | 1987 | 10034761 | Yes |
| 1697 | 2241 | 1120.5 | 49.28 | 24.6 | Cancer genes and the pathways they control. | Bert Vogelstein, Kenneth W Kinzler | Nat. Med. | 2004 | 15286780 | No |
| 1698 | 2241 | 1120.5 | 77.62 | 38.8 | Autophagy: renovation of cells and tissues. | Noboru Mizushima, Masaaki Komatsu | Cell | 2011 | 22078875 | No |
| 1699 | 1120 | 1120.0 | 0.0 | 0.0 | Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. | C A Barnes | J Comp Physiol Psychol | 1979 | 221551 | Yes |
| 1700 | 1120 | 1120.0 | 0.0 | 0.0 | The oxidation of ribonuclease with performic acid. | C H HIRS | J. Biol. Chem. | 1956 | 13319283 | Yes |
| 1701 | 1120 | 1120.0 | 32.47 | 32.5 | The failing heart--an engine out of fuel. | Stefan Neubauer | N. Engl. J. Med. | 2007 | 17360992 | No |
| 1702 | 1120 | 1120.0 | 33.71 | 33.7 | Using circular dichroism spectra to estimate protein secondary structure. | Norma J Greenfield | Nat Protoc | 2006 | 17406547 | Yes |
| 1703 | 1120 | 1120.0 | 45.84 | 45.8 | Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. | Joseph J Volpe | Lancet Neurol | 2009 | 19081519 | No |
| 1704 | 6718 | 1119.7 | 198.49 | 33.1 | Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. | D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuire | Science | 1987 | 3798106 | Yes |
| 1705 | 2238 | 1119.0 | 0.0 | 0.0 | New Giemsa method for the differential staining of sister chromatids. | P Perry, S Wolff | Nature | 1974 | 4138930 | Yes |
| 1706 | 1119 | 1119.0 | 44.7 | 44.7 | G proteins and dual control of adenylate cyclase. | A G Gilman | Cell | 1984 | 6321035 | Yes |
| 1707 | 1119 | 1119.0 | 21.57 | 21.6 | Protein modification by SUMO. | Erica S Johnson | Annu. Rev. Biochem. | 2004 | 15189146 | No |
| 1708 | 2237 | 1118.5 | 68.1 | 34.0 | Obesity. | David W Haslam, W Philip T James | Lancet | 2005 | 16198769 | No |
| 1709 | 2236 | 1118.0 | 0.0 | 0.0 | Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. | M Mihara, M Uchiyama | Anal. Biochem. | 1978 | 655387 | Yes |
| 1710 | 1118 | 1118.0 | 0.0 | 0.0 | PLASTIC EMBEDDING MIXTURES FOR USE IN ELECTRON MICROSCOPY. | H H MOLLENHAUER | Stain Technol | 1964 | 14127791 | Yes |
| 1711 | 1116 | 1116.0 | 27.4 | 27.4 | DNA in a material world. | Nadrian C Seeman | Nature | 2003 | 12540916 | No |
| 1712 | 3348 | 1116.0 | 91.5 | 30.5 | Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. | Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck Ørntoft | Cancer Res. | 2004 | 15289330 | Yes |
| 1713 | 1116 | 1116.0 | 32.61 | 32.6 | Myeloperoxidase: friend and foe. | Seymour J Klebanoff | J. Leukoc. Biol. | 2005 | 15689384 | No |
| 1714 | 2230 | 1115.0 | 65.91 | 33.0 | Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. | E S Lander, D Botstein | Genetics | 1989 | 2563713 | Yes |
| 1715 | 1115 | 1115.0 | 45.61 | 45.6 | The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. | L W Swanson | Brain Res. Bull. | 1982 | 6816390 | Yes |
| 1716 | 1114 | 1114.0 | 50.03 | 50.0 | Aging, natural death, and the compression of morbidity. | J F Fries | N. Engl. J. Med. | 1980 | 7383070 | Yes |
| 1717 | 1114 | 1114.0 | 38.04 | 38.0 | Molecular bases of the acute coronary syndromes. | P Libby | Circulation | 1995 | 7758192 | No |
| 1718 | 2226 | 1113.0 | 68.76 | 34.4 | The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. | P Angel, M Karin | Biochim. Biophys. Acta | 1991 | 1751545 | No |
| 1719 | 1113 | 1113.0 | 43.06 | 43.1 | Efficient analysis of experimental observations. | W J Dixon | Annu. Rev. Pharmacol. Toxicol. | 1980 | 7387124 | Yes |
| 1720 | 1113 | 1113.0 | 27.9 | 27.9 | The NCI60 human tumour cell line anticancer drug screen. | Robert H Shoemaker | Nat. Rev. Cancer | 2006 | 16990858 | No |
| 1721 | 2223 | 1111.5 | 0.0 | 0.0 | Synchronization of Plasmodium falciparum erythrocytic stages in culture. | C Lambros, J P Vanderberg | J. Parasitol. | 1979 | 383936 | Yes |
| 1722 | 1111 | 1111.0 | 31.83 | 31.8 | Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. | B Winkel-Shirley | Plant Physiol. | 2001 | 11402179 | No |
| 1723 | 1110 | 1110.0 | 0.0 | 0.0 | Mate selection-a selection for a handicap. | A Zahavi | J. Theor. Biol. | 1975 | 1195756 | Yes |
| 1724 | 2219 | 1109.5 | 82.92 | 41.5 | Biochemistry of multidrug resistance mediated by the multidrug transporter. | M M Gottesman, I Pastan | Annu. Rev. Biochem. | 1993 | 8102521 | No |
| 1725 | 2219 | 1109.5 | 62.82 | 31.4 | Interneurons of the hippocampus. | T F Freund, G Buzsáki | Hippocampus | 1996 | 8915675 | No |
| 1726 | 1109 | 1109.0 | 73.22 | 73.2 | Chronic illness as biographical disruption. | M Bury | Sociol Health Illn | 1982 | 10260456 | Yes |
| 1727 | 1108 | 1108.0 | 34.65 | 34.6 | Hemispheric asymmetry reduction in older adults: the HAROLD model. | Roberto Cabeza | Psychol Aging | 2002 | 11931290 | No |
| 1728 | 4429 | 1107.2 | 250.33 | 62.6 | jModelTest 2: more models, new heuristics and parallel computing. | Diego Darriba, Guillermo L Taboada, Ramón Doallo, David Posada | Nat. Methods | 2012 | 22847109 | Yes |
| 1729 | 1106 | 1106.0 | 45.18 | 45.2 | Metalloproteinases and their inhibitors in matrix remodeling. | L M Matrisian | Trends Genet. | 1990 | 2132731 | No |
| 1730 | 3318 | 1106.0 | 103.64 | 34.5 | Cognitive and emotional influences in anterior cingulate cortex. | Bush, Luu, Posner | Trends Cogn. Sci. (Regul. Ed.) | 2000 | 10827444 | Yes |
| 1731 | 1105 | 1105.0 | 0.0 | 0.0 | ATPase activity of myosin correlated with speed of muscle shortening. | M Bárány | J. Gen. Physiol. | 1967 | 4227924 | Yes |
| 1732 | 2210 | 1105.0 | 93.57 | 46.8 | Shifting the genomic gold standard for the prokaryotic species definition. | Michael Richter, Ramon Rosselló-Móra | Proc. Natl. Acad. Sci. U.S.A. | 2009 | 19855009 | Yes |
| 1733 | 4419 | 1104.8 | 148.84 | 37.2 | Comorbidity measures for use with administrative data. | A Elixhauser, C Steiner, D R Harris, R M Coffey | Med Care | 1998 | 9431328 | Yes |
| 1734 | 1104 | 1104.0 | 25.76 | 25.8 | Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. | R I Morimoto | Genes Dev. | 1998 | 9869631 | No |
| 1735 | 1104 | 1104.0 | 45.58 | 45.6 | A new automated colorimetric method for measuring total oxidant status. | Ozcan Erel | Clin. Biochem. | 2005 | 16214125 | Yes |
| 1736 | 1103 | 1103.0 | 37.65 | 37.6 | Redox signaling: nitrosylation and related target interactions of nitric oxide. | J S Stamler | Cell | 1994 | 7923362 | No |
| 1737 | 1103 | 1103.0 | 41.79 | 41.8 | Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. | M Robin DiMatteo | Med Care | 2004 | 15076819 | Yes |
| 1738 | 1102 | 1102.0 | 30.99 | 31.0 | Regulation of differentiation of vascular smooth muscle cells. | G K Owens | Physiol. Rev. | 1995 | 7624392 | No |
| 1739 | 1102 | 1102.0 | 31.52 | 31.5 | The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. | H Maeda | Adv. Enzyme Regul. | 2001 | 11384745 | No |
| 1740 | 1101 | 1101.0 | 42.3 | 42.3 | Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. | M D Maines | FASEB J. | 1988 | 3290025 | No |
| 1741 | 2202 | 1101.0 | 65.85 | 32.9 | Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. | M A Nitsche, W Paulus | J. Physiol. (Lond.) | 2000 | 10990547 | Yes |
| 1742 | 2201 | 1100.5 | 52.46 | 26.2 | The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. | M S Brown, J L Goldstein | Cell | 1997 | 9150132 | No |
| 1743 | 1100 | 1100.0 | 0.0 | 0.0 | Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. | W H Oldendorf | Am. J. Physiol. | 1971 | 5124307 | Yes |
| 1744 | 7700 | 1100.0 | 283.22 | 40.5 | Cancer statistics, 2008. | Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J Thun | CA Cancer J Clin | 2008 | 18287387 | Yes |
| 1745 | 2199 | 1099.5 | 43.34 | 21.7 | Rab proteins as membrane organizers. | M Zerial, H McBride | Nat. Rev. Mol. Cell Biol. | 2001 | 11252952 | No |
| 1746 | 2199 | 1099.5 | 48.66 | 24.3 | Wnt signalling in stem cells and cancer. | Tannishtha Reya, Hans Clevers | Nature | 2005 | 15829953 | No |
| 1747 | 1099 | 1099.0 | 29.14 | 29.1 | Neurotrophin-regulated signalling pathways. | Louis F Reichardt | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | 2006 | 16939974 | No |
| 1748 | 1098 | 1098.0 | 50.96 | 51.0 | Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. | C E Mogensen | N. Engl. J. Med. | 1984 | 6690964 | Yes |
| 1749 | 1098 | 1098.0 | 23.84 | 23.8 | NK cell receptors. | L L Lanier | Annu. Rev. Immunol. | 1998 | 9597134 | No |
| 1750 | 1098 | 1098.0 | 24.4 | 24.4 | Macromolecular crowding: obvious but underappreciated. | R J Ellis | Trends Biochem. Sci. | 2001 | 11590012 | No |
| 1751 | 1098 | 1098.0 | 30.77 | 30.8 | Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). | K M Fox | Lancet | 2003 | 13678872 | Yes |
| 1752 | 1098 | 1098.0 | 46.01 | 46.0 | Cognitive reserve. | Yaakov Stern | Neuropsychologia | 2009 | 19467352 | No |
| 1753 | 1097 | 1097.0 | 31.44 | 31.4 | Oxidative stress in Parkinson's disease. | Peter Jenner | Ann. Neurol. | 2003 | 12666096 | No |
| 1754 | 2194 | 1097.0 | 0.0 | 0.0 | Convergent and discriminant validation by the multitrait-multimethod matrix. | D T CAMPBELL, D W FISKE | Psychol Bull | 1959 | 13634291 | Yes |
| 1755 | 1097 | 1097.0 | 34.44 | 34.4 | External validity of randomised controlled trials: "to whom do the results of this trial apply?". | Peter M Rothwell | Lancet | 2005 | 15639683 | Yes |
| 1756 | 1097 | 1097.0 | 34.24 | 34.2 | P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation. | Berk Hess | J Chem Theory Comput | 2008 | 26619985 | Yes |
| 1757 | 2193 | 1096.5 | 52.44 | 26.2 | Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. | J M Kyriakis, J Avruch | Physiol. Rev. | 2001 | 11274345 | No |
| 1758 | 1096 | 1096.0 | 35.91 | 35.9 | A note on robust variance estimation for cluster-correlated data. | R L Williams | Biometrics | 2000 | 10877330 | Yes |
| 1759 | 4382 | 1095.5 | 128.75 | 32.2 | Most mammalian mRNAs are conserved targets of microRNAs. | Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P Bartel | Genome Res. | 2009 | 18955434 | Yes |
| 1760 | 1095 | 1095.0 | 35.14 | 35.1 | Thioredoxin and glutaredoxin systems. | A Holmgren | J. Biol. Chem. | 1989 | 2668278 | No |
| 1761 | 1095 | 1095.0 | 57.84 | 57.8 | Physiological aspects of primary hypertension. | B Folkow | Physiol. Rev. | 1982 | 6461865 | No |
| 1762 | 1095 | 1095.0 | 22.29 | 22.3 | Regulatory T cells: key controllers of immunologic self-tolerance. | S Sakaguchi | Cell | 2000 | 10850488 | No |
| 1763 | 4379 | 1094.8 | 164.35 | 41.1 | The validity of the Hospital Anxiety and Depression Scale. An updated literature review. | Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag Neckelmann | J Psychosom Res | 2002 | 11832252 | No |
| 1764 | 1094 | 1094.0 | 0.0 | 0.0 | The recurrence of intracranial meningiomas after surgical treatment. | D SIMPSON | J. Neurol. Neurosurg. Psychiatry | 1957 | 13406590 | Yes |
| 1765 | 1094 | 1094.0 | 0.0 | 0.0 | Structural considerations in the interaction of DNA and acridines. | L S LERMAN | J. Mol. Biol. | 1961 | 13761054 | Yes |
| 1766 | 2187 | 1093.5 | 0.0 | 0.0 | New method for quantitative determination of uronic acids. | N Blumenkrantz, G Asboe-Hansen | Anal. Biochem. | 1973 | 4269305 | Yes |
| 1767 | 4372 | 1093.0 | 105.52 | 26.4 | MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. | Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi Miyata | Nucleic Acids Res. | 2002 | 12136088 | Yes |
| 1768 | 1093 | 1093.0 | 54.47 | 54.5 | Doxil®--the first FDA-approved nano-drug: lessons learned. | Yechezkel Barenholz | J Control Release | 2012 | 22484195 | No |
| 1769 | 5458 | 1091.6 | 0.0 | 0.0 | STUDIES OF ILLNESS IN THE AGED. THE INDEX OF ADL: A STANDARDIZED MEASURE OF BIOLOGICAL AND PSYCHOSOCIAL FUNCTION. | S KATZ, A B FORD, R W MOSKOWITZ, B A JACKSON, M W JAFFE | JAMA | 1963 | 14044222 | Yes |
| 1770 | 4366 | 1091.5 | 263.71 | 65.9 | The Satisfaction With Life Scale. | E Diener, R A Emmons, R J Larsen, S Griffin | J Pers Assess | 1985 | 16367493 | Yes |
| 1771 | 1091 | 1091.0 | 42.6 | 42.6 | The functional gastrointestinal disorders and the Rome III process. | Douglas A Drossman | Gastroenterology | 2006 | 16678553 | No |
| 1772 | 2182 | 1091.0 | 86.51 | 43.3 | Density functionals with broad applicability in chemistry. | Yan Zhao, Donald G Truhlar | Acc. Chem. Res. | 2008 | 18186612 | Yes |
| 1773 | 1090 | 1090.0 | 21.6 | 21.6 | The snail superfamily of zinc-finger transcription factors. | M Angela Nieto | Nat. Rev. Mol. Cell Biol. | 2002 | 11994736 | No |
| 1774 | 2178 | 1089.0 | 0.0 | 0.0 | The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. | J O'Keefe, J Dostrovsky | Brain Res. | 1971 | 5124915 | Yes |
| 1775 | 1089 | 1089.0 | 49.4 | 49.4 | Frontal-subcortical circuits and human behavior. | J L Cummings | Arch. Neurol. | 1993 | 8352676 | No |
| 1776 | 1089 | 1089.0 | 27.27 | 27.3 | Protein misfolding, evolution and disease. | C M Dobson | Trends Biochem. Sci. | 1999 | 10470028 | No |
| 1777 | 1089 | 1089.0 | 29.96 | 30.0 | Refined structure of the nicotinic acetylcholine receptor at 4A resolution. | Nigel Unwin | J. Mol. Biol. | 2005 | 15701510 | Yes |
| 1778 | 2177 | 1088.5 | 0.0 | 0.0 | A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. | J A Horne, O Ostberg | Int J Chronobiol | 1976 | 1027738 | Yes |
| 1779 | 1088 | 1088.0 | 0.0 | 0.0 | Stimulated acoustic emissions from within the human auditory system. | D T Kemp | J. Acoust. Soc. Am. | 1978 | 744838 | Yes |
| 1780 | 1088 | 1088.0 | 33.98 | 34.0 | Rapid and sensitive sequence comparison with FASTP and FASTA. | W R Pearson | Meth. Enzymol. | 1990 | 2156132 | Yes |
| 1781 | 1088 | 1088.0 | 60.0 | 60.0 | A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. | D J Schuirmann | J Pharmacokinet Biopharm | 1987 | 3450848 | Yes |
| 1782 | 2176 | 1088.0 | 164.5 | 82.2 | Rating systems in the evaluation of knee ligament injuries. | Y Tegner, J Lysholm | Clin. Orthop. Relat. Res. | 1985 | 4028566 | Yes |
| 1783 | 1087 | 1087.0 | 0.0 | 0.0 | CHROMATOGRAPHIC SEPARATION OF HUMAN BRAIN GANGLIOSIDES. | L SVENNERHOLM | J. Neurochem. | 1963 | 14066623 | Yes |
| 1784 | 1087 | 1087.0 | 48.34 | 48.3 | Falls in older people: epidemiology, risk factors and strategies for prevention. | Laurence Z Rubenstein | Age Ageing | 2006 | 16926202 | No |
| 1785 | 3257 | 1085.7 | 94.97 | 31.7 | Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. | B Fischl, M I Sereno, A M Dale | Neuroimage | 1999 | 9931269 | Yes |
| 1786 | 1085 | 1085.0 | 0.0 | 0.0 | Estimability and estimation in case-referent studies. | O Miettinen | Am. J. Epidemiol. | 1976 | 1251836 | Yes |
| 1787 | 1085 | 1085.0 | 31.73 | 31.7 | The use of nanocrystals in biological detection. | Paul Alivisatos | Nat. Biotechnol. | 2004 | 14704706 | Yes |
| 1788 | 2170 | 1085.0 | 76.0 | 38.0 | Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. | Sally S Dickerson, Margaret E Kemeny | Psychol Bull | 2004 | 15122924 | Yes |
| 1789 | 1085 | 1085.0 | 37.77 | 37.8 | The debate over dopamine's role in reward: the case for incentive salience. | Kent C Berridge | Psychopharmacology (Berl.) | 2007 | 17072591 | No |
| 1790 | 1085 | 1085.0 | 39.48 | 39.5 | Surface plasmon resonance sensors for detection of chemical and biological species. | Jirí Homola | Chem. Rev. | 2008 | 18229953 | No |
| 1791 | 2169 | 1084.5 | 45.77 | 22.9 | Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. | C Li, W H Wong | Proc. Natl. Acad. Sci. U.S.A. | 2001 | 11134512 | Yes |
| 1792 | 4337 | 1084.2 | 204.46 | 51.1 | Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. | Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg Lang | Behav Res Methods | 2009 | 19897823 | Yes |
| 1793 | 1084 | 1084.0 | 46.33 | 46.3 | Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. | N Krieger | Am J Public Health | 1992 | 1566949 | Yes |
| 1794 | 1084 | 1084.0 | 0.0 | 0.0 | Isolated removal of hypothalamic or other brain nuclei of the rat. | M Palkovits | Brain Res. | 1973 | 4747772 | Yes |
| 1795 | 1084 | 1084.0 | 0.0 | 0.0 | The statistical analysis of enzyme kinetic data. | W W Cleland | Adv. Enzymol. Relat. Areas Mol. Biol. | 1967 | 4881884 | No |
| 1796 | 1084 | 1084.0 | 27.26 | 27.3 | Cancer of the ovary. | Stephen A Cannistra | N. Engl. J. Med. | 2004 | 15590954 | No |
| 1797 | 2168 | 1084.0 | 54.25 | 27.1 | Cancer metastasis: building a framework. | Gaorav P Gupta, Joan Massagué | Cell | 2006 | 17110329 | No |
| 1798 | 2167 | 1083.5 | 85.04 | 42.5 | Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. | G R Gibson, M B Roberfroid | J. Nutr. | 1995 | 7782892 | No |
| 1799 | 1083 | 1083.0 | 43.25 | 43.2 | Neurotransmitters and neuromodulators in the basal ganglia. | A M Graybiel | Trends Neurosci. | 1990 | 1695398 | No |
| 1800 | 1083 | 1083.0 | 39.33 | 39.3 | Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. | A Fabiato | Am. J. Physiol. | 1983 | 6346892 | No |
| 1801 | 1083 | 1083.0 | 31.0 | 31.0 | Functions of ceramide in coordinating cellular responses to stress. | Y A Hannun | Science | 1996 | 8943189 | No |
| 1802 | 2165 | 1082.5 | 69.83 | 34.9 | ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. | B Ravel, M Newville | J Synchrotron Radiat | 2005 | 15968136 | Yes |
| 1803 | 2164 | 1082.0 | 70.74 | 35.4 | The expanding universe of T-cell subsets: Th1, Th2 and more. | T R Mosmann, S Sad | Immunol. Today | 1996 | 8820272 | No |
| 1804 | 1082 | 1082.0 | 36.91 | 36.9 | A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. | J Engel | Epilepsia | 2001 | 11422340 | Yes |
| 1805 | 2163 | 1081.5 | 0.0 | 0.0 | The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. | A E Bolton, W M Hunter | Biochem. J. | 1973 | 4733239 | Yes |
| 1806 | 2162 | 1081.0 | 0.0 | 0.0 | THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES. | T OMURA, R SATO | J. Biol. Chem. | 1964 | 14209972 | Yes |
| 1807 | 2161 | 1080.5 | 77.41 | 38.7 | EQ-5D: a measure of health status from the EuroQol Group. | R Rabin, F de Charro | Ann. Med. | 2001 | 11491192 | No |
| 1808 | 2161 | 1080.5 | 50.14 | 25.1 | Short-term synaptic plasticity. | Robert S Zucker, Wade G Regehr | Annu. Rev. Physiol. | 2002 | 11826273 | No |
| 1809 | 2160 | 1080.0 | 104.47 | 52.2 | A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. | C M Tsai, C E Frasch | Anal. Biochem. | 1982 | 6176137 | Yes |
| 1810 | 1080 | 1080.0 | 19.62 | 19.6 | The economics of ribosome biosynthesis in yeast. | J R Warner | Trends Biochem. Sci. | 1999 | 10542411 | No |
| 1811 | 1080 | 1080.0 | 26.79 | 26.8 | Critical period plasticity in local cortical circuits. | Takao K Hensch | Nat. Rev. Neurosci. | 2005 | 16261181 | No |
| 1812 | 2158 | 1079.0 | 83.04 | 41.5 | Polyamines. | C W Tabor, H Tabor | Annu. Rev. Biochem. | 1984 | 6206782 | No |
| 1813 | 1079 | 1079.0 | 35.66 | 35.7 | The epidemiology of venous thromboembolism. | Richard H White | Circulation | 2003 | 12814979 | No |
| 1814 | 3236 | 1078.7 | 96.37 | 32.1 | Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. | M A Frohman, M K Dush, G R Martin | Proc. Natl. Acad. Sci. U.S.A. | 1988 | 2461560 | Yes |
| 1815 | 2157 | 1078.5 | 83.65 | 41.8 | Functional architecture of basal ganglia circuits: neural substrates of parallel processing. | G E Alexander, M D Crutcher | Trends Neurosci. | 1990 | 1695401 | No |
| 1816 | 2156 | 1078.0 | 50.05 | 25.0 | The molecular biology of axon guidance. | M Tessier-Lavigne, C S Goodman | Science | 1996 | 8895455 | No |
| 1817 | 1078 | 1078.0 | 21.54 | 21.5 | Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. | M G Gustafsson | J Microsc | 2000 | 10810003 | Yes |
| 1818 | 1078 | 1078.0 | 19.48 | 19.5 | Cancer. Addiction to oncogenes--the Achilles heal of cancer. | I Bernard Weinstein | Science | 2002 | 12098689 | No |
| 1819 | 1078 | 1078.0 | 42.91 | 42.9 | Social relationships and health. | Sheldon Cohen | Am Psychol | 2004 | 15554821 | No |
| 1820 | 1077 | 1077.0 | 0.0 | 0.0 | Microbial ecology of the gastrointestinal tract. | D C Savage | Annu. Rev. Microbiol. | 1977 | 334036 | No |
| 1821 | 2152 | 1076.0 | 59.67 | 29.8 | The MAPK signaling cascade. | R Seger, E G Krebs | FASEB J. | 1995 | 7601337 | No |
| 1822 | 1076 | 1076.0 | 47.57 | 47.6 | Phase retrieval algorithms: a comparison. | J R Fienup | Appl Opt | 1982 | 20396114 | Yes |
| 1823 | 1075 | 1075.0 | 0.0 | 0.0 | Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. | A Krishan | J. Cell Biol. | 1975 | 49354 | Yes |
| 1824 | 3220 | 1073.3 | 88.64 | 29.5 | The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. | S K Hanks, A M Quinn, T Hunter | Science | 1988 | 3291115 | No |
| 1825 | 2145 | 1072.5 | 69.83 | 34.9 | Materials for electrochemical capacitors. | Patrice Simon, Yury Gogotsi | Nat Mater | 2008 | 18956000 | Yes |
| 1826 | 2145 | 1072.5 | 53.29 | 26.6 | NMR View: A computer program for the visualization and analysis of NMR data. | B A Johnson, R A Blevins | J. Biomol. NMR | 1994 | 22911360 | Yes |
| 1827 | 4288 | 1072.0 | 0.0 | 0.0 | A rating scale for mania: reliability, validity and sensitivity. | R C Young, J T Biggs, V E Ziegler, D A Meyer | Br J Psychiatry | 1978 | 728692 | Yes |
| 1828 | 2144 | 1072.0 | 0.0 | 0.0 | Computed circular dichroism spectra for the evaluation of protein conformation. | N Greenfield, G D Fasman | Biochemistry | 1969 | 5346390 | Yes |
| 1829 | 1072 | 1072.0 | 25.17 | 25.2 | Endocytosis and molecular sorting. | I Mellman | Annu. Rev. Cell Dev. Biol. | 1996 | 8970738 | No |
| 1830 | 1072 | 1072.0 | 40.24 | 40.2 | Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. | James J P Stewart | J Mol Model | 2007 | 17828561 | Yes |
| 1831 | 2143 | 1071.5 | 76.12 | 38.1 | Angiogenesis. | J Folkman, Y Shing | J. Biol. Chem. | 1992 | 1375931 | No |
| 1832 | 2143 | 1071.5 | 45.04 | 22.5 | Genetic transformation of Drosophila with transposable element vectors. | G M Rubin, A C Spradling | Science | 1982 | 6289436 | Yes |
| 1833 | 1071 | 1071.0 | 0.0 | 0.0 | The mechanism of muscular contraction. | H E Huxley | Science | 1969 | 4181952 | No |
| 1834 | 1071 | 1071.0 | 43.95 | 44.0 | The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. | G R Buettner | Arch. Biochem. Biophys. | 1993 | 8434935 | No |
| 1835 | 2142 | 1071.0 | 0.0 | 0.0 | Junctional complexes in various epithelia. | M G FARQUHAR, G E PALADE | J. Cell Biol. | 1963 | 13944428 | Yes |
| 1836 | 2140 | 1070.0 | 108.53 | 54.3 | Assessment of eating disorders: interview or self-report questionnaire? | C G Fairburn, S J Beglin | Int J Eat Disord | 1994 | 7866415 | Yes |
| 1837 | 1070 | 1070.0 | 45.91 | 45.9 | Dual-task interference in simple tasks: data and theory. | H Pashler | Psychol Bull | 1994 | 7972591 | No |
| 1838 | 1070 | 1070.0 | 31.77 | 31.8 | Drug-induced prolongation of the QT interval. | Dan M Roden | N. Engl. J. Med. | 2004 | 14999113 | No |
| 1839 | 3204 | 1068.0 | 0.0 | 0.0 | Hydroperoxide metabolism in mammalian organs. | B Chance, H Sies, A Boveris | Physiol. Rev. | 1979 | 37532 | Yes |
| 1840 | 1068 | 1068.0 | 30.06 | 30.1 | Developmental cell death: morphological diversity and multiple mechanisms. | P G Clarke | Anat. Embryol. | 1990 | 2186664 | No |
| 1841 | 1068 | 1068.0 | 30.87 | 30.9 | The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. | M Takeichi | Development | 1988 | 3048970 | No |
| 1842 | 1068 | 1068.0 | 60.02 | 60.0 | Mood and memory. | G H Bower | Am Psychol | 1981 | 7224324 | Yes |
| 1843 | 1068 | 1068.0 | 42.74 | 42.7 | Domino Reactions in Organic Synthesis. | Lutz F. Tietze | Chem. Rev. | 1996 | 11848746 | Yes |
| 1844 | 1068 | 1068.0 | 33.22 | 33.2 | Integration, scaling, space-group assignment and post-refinement. | Wolfgang Kabsch | Acta Crystallogr. D Biol. Crystallogr. | 2010 | 20124693 | Yes |
| 1845 | 2135 | 1067.5 | 0.0 | 0.0 | A scaled version of the General Health Questionnaire. | D P Goldberg, V F Hillier | Psychol Med | 1979 | 424481 | Yes |
| 1846 | 3201 | 1067.0 | 61.73 | 20.6 | A system for stable expression of short interfering RNAs in mammalian cells. | Thijn R Brummelkamp, René Bernards, Reuven Agami | Science | 2002 | 11910072 | Yes |
| 1847 | 2133 | 1066.5 | 0.0 | 0.0 | 3' non-coding region sequences in eukaryotic messenger RNA. | N J Proudfoot, G G Brownlee | Nature | 1976 | 822353 | Yes |
| 1848 | 2133 | 1066.5 | 75.16 | 37.6 | Mortality by cause for eight regions of the world: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9142060 | Yes |
| 1849 | 1066 | 1066.0 | 32.84 | 32.8 | Genetic consequences of climatic oscillations in the Quaternary. | G M Hewitt | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | 2004 | 15101575 | No |
| 1850 | 2131 | 1065.5 | 76.43 | 38.2 | Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. | C J Murray, A D Lopez | Lancet | 1997 | 9164317 | Yes |
| 1851 | 1065 | 1065.0 | 48.11 | 48.1 | Recent advances in the biochemistry of polyamines in eukaryotes. | A E Pegg | Biochem. J. | 1986 | 3087344 | No |
| 1852 | 1065 | 1065.0 | 26.66 | 26.7 | Autophagy: from phenomenology to molecular understanding in less than a decade. | Daniel J Klionsky | Nat. Rev. Mol. Cell Biol. | 2007 | 17712358 | No |
| 1853 | 9580 | 1064.4 | 359.35 | 39.9 | The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. | D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C Dunbar | J Clin Psychiatry | 1998 | 9881538 | No |
| 1854 | 2127 | 1063.5 | 52.22 | 26.1 | LTP and LTD: an embarrassment of riches. | Robert C Malenka, Mark F Bear | Neuron | 2004 | 15450156 | No |
| 1855 | 1063 | 1063.0 | 39.14 | 39.1 | Systemic lupus erythematosus. | George C Tsokos | N. Engl. J. Med. | 2011 | 22129255 | No |
| 1856 | 6375 | 1062.5 | 244.99 | 40.8 | New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. | Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier Gascuel | Syst. Biol. | 2010 | 20525638 | Yes |
| 1857 | 1062 | 1062.0 | 94.14 | 94.1 | The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. | F C Ewald | Clin. Orthop. Relat. Res. | 1989 | 2805502 | Yes |
| 1858 | 1061 | 1061.0 | 27.32 | 27.3 | E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. | J R Nevins | Science | 1992 | 1411535 | Yes |
| 1859 | 2122 | 1061.0 | 55.46 | 27.7 | Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. | P J Mitchell, R Tjian | Science | 1989 | 2667136 | No |
| 1860 | 1061 | 1061.0 | 75.39 | 75.4 | Presynaptic regulation of the release of catecholamines. | S Z Langer | Pharmacol. Rev. | 1980 | 6267618 | Yes |
| 1861 | 2122 | 1061.0 | 93.74 | 46.9 | The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. | R Doll, R Peto | J. Natl. Cancer Inst. | 1981 | 7017215 | No |
| 1862 | 2122 | 1061.0 | 59.26 | 29.6 | NF-kappa B: ten years after. | P A Baeuerle, D Baltimore | Cell | 1996 | 8858144 | No |
| 1863 | 2121 | 1060.5 | 0.0 | 0.0 | Mutations of Bacteria from Virus Sensitivity to Virus Resistance. | S E Luria, M Delbrück | Genetics | 1943 | 17247100 | Yes |
| 1864 | 3181 | 1060.3 | 75.49 | 25.2 | A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. | R Medzhitov, P Preston-Hurlburt, C A Janeway | Nature | 1997 | 9237759 | Yes |
| 1865 | 2120 | 1060.0 | 67.24 | 33.6 | Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. | I Issemann, S Green | Nature | 1990 | 2129546 | Yes |
| 1866 | 4238 | 1059.5 | 0.0 | 0.0 | A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. | M A Markwell, S M Haas, L L Bieber, N E Tolbert | Anal. Biochem. | 1978 | 98070 | Yes |
| 1867 | 3176 | 1058.7 | 81.65 | 27.2 | Telomeres shorten during ageing of human fibroblasts. | C B Harley, A B Futcher, C W Greider | Nature | 1990 | 2342578 | Yes |
| 1868 | 2117 | 1058.5 | 71.78 | 35.9 | Lipid rafts as a membrane-organizing principle. | Daniel Lingwood, Kai Simons | Science | 2010 | 20044567 | No |
| 1869 | 1058 | 1058.0 | 45.45 | 45.5 | Plasma perspective on strong field multiphoton ionization. | Corkum | Phys. Rev. Lett. | 1993 | 10054556 | Yes |
| 1870 | 1057 | 1057.0 | 55.71 | 55.7 | A structured interview guide for the Hamilton Depression Rating Scale. | J B Williams | Arch. Gen. Psychiatry | 1988 | 3395203 | Yes |
| 1871 | 1057 | 1057.0 | 25.82 | 25.8 | Drug discovery: a historical perspective. | J Drews | Science | 2000 | 10720314 | No |
| 1872 | 1057 | 1057.0 | 21.12 | 21.1 | SUMO: a history of modification. | Ronald T Hay | Mol. Cell | 2005 | 15808504 | No |
| 1873 | 1057 | 1057.0 | 26.92 | 26.9 | Mitochondria: dynamic organelles in disease, aging, and development. | David C Chan | Cell | 2006 | 16814712 | No |
| 1874 | 3169 | 1056.3 | 80.78 | 26.9 | Osteoclast differentiation and activation. | William J Boyle, W Scott Simonet, David L Lacey | Nature | 2003 | 12748652 | No |
| 1875 | 1056 | 1056.0 | 46.5 | 46.5 | Metallothionein. | D H Hamer | Annu. Rev. Biochem. | 1986 | 3527054 | No |
| 1876 | 1056 | 1056.0 | 0.0 | 0.0 | RNA-dependent DNA polymerase in virions of RNA tumour viruses. | D Baltimore | Nature | 1970 | 4316300 | Yes |
| 1877 | 1056 | 1056.0 | 36.82 | 36.8 | Circuitry and functional aspects of the insular lobe in primates including humans. | J R Augustine | Brain Res. Brain Res. Rev. | 1996 | 8957561 | No |
| 1878 | 1056 | 1056.0 | 27.33 | 27.3 | Hyaluronan: from extracellular glue to pericellular cue. | Bryan P Toole | Nat. Rev. Cancer | 2004 | 15229478 | No |
| 1879 | 4223 | 1055.8 | 114.08 | 28.5 | Quantitative monitoring of gene expression patterns with a complementary DNA microarray. | M Schena, D Shalon, R W Davis, P O Brown | Science | 1995 | 7569999 | Yes |
| 1880 | 2111 | 1055.5 | 80.92 | 40.5 | The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. | J D Hayes, D J Pulford | Crit. Rev. Biochem. Mol. Biol. | 1995 | 8770536 | No |
| 1881 | 1055 | 1055.0 | 33.77 | 33.8 | Hydrogels for biomedical applications. | Allan S Hoffman | Adv. Drug Deliv. Rev. | 2002 | 11755703 | No |
| 1882 | 1054 | 1054.0 | 19.82 | 19.8 | Clonal selection and learning in the antibody system. | K Rajewsky | Nature | 1996 | 8657279 | No |
| 1883 | 1054 | 1054.0 | 29.55 | 29.6 | Optimal experimental design for event-related fMRI. | A M Dale | Hum Brain Mapp | 1999 | 10524601 | Yes |
| 1884 | 1054 | 1054.0 | 36.41 | 36.4 | Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. | E B Hunziker | Osteoarthr. Cartil. | 2002 | 12056848 | No |
| 1885 | 1054 | 1054.0 | 0.0 | 0.0 | THE RELATION OF RECOMBINATION TO MUTATIONAL ADVANCE. | H J MULLER | Mutat. Res. | 1964 | 14195748 | Yes |
| 1886 | 2107 | 1053.5 | 45.98 | 23.0 | Prediction of complete gene structures in human genomic DNA. | C Burge, S Karlin | J. Mol. Biol. | 1997 | 9149143 | Yes |
| 1887 | 3160 | 1053.3 | 89.94 | 30.0 | Thresholding of statistical maps in functional neuroimaging using the false discovery rate. | Christopher R Genovese, Nicole A Lazar, Thomas Nichols | Neuroimage | 2002 | 11906227 | Yes |
| 1888 | 2106 | 1053.0 | 44.42 | 22.2 | Oncogenic kinase signalling. | P Blume-Jensen, T Hunter | Nature | 2001 | 11357143 | No |
| 1889 | 1053 | 1053.0 | 41.93 | 41.9 | Formation of glasses from liquids and biopolymers. | C A Angell | Science | 1995 | 17770101 | Yes |
| 1890 | 1052 | 1052.0 | 54.1 | 54.1 | The role of hormone receptors and GTP-regulatory proteins in membrane transduction. | M Rodbell | Nature | 1980 | 6101906 | Yes |
| 1891 | 1052 | 1052.0 | 32.47 | 32.5 | Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. | M Kozak | Microbiol. Rev. | 1983 | 6343825 | No |
| 1892 | 1052 | 1052.0 | 26.21 | 26.2 | The ATP synthase--a splendid molecular machine. | P D Boyer | Annu. Rev. Biochem. | 1997 | 9242922 | No |
| 1893 | 1052 | 1052.0 | 26.91 | 26.9 | HIF-1: mediator of physiological and pathophysiological responses to hypoxia. | G L Semenza | J. Appl. Physiol. | 2000 | 10749844 | No |
| 1894 | 2103 | 1051.5 | 52.28 | 26.1 | Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. | Joshua E Elias, Steven P Gygi | Nat. Methods | 2007 | 17327847 | Yes |
| 1895 | 1051 | 1051.0 | 0.0 | 0.0 | The theory and applications of the exchange of inert gas at the lungs and tissues. | S S KETY | Pharmacol. Rev. | 1951 | 14833874 | Yes |
| 1896 | 2101 | 1050.5 | 52.75 | 26.4 | Microtubules as a target for anticancer drugs. | Mary Ann Jordan, Leslie Wilson | Nat. Rev. Cancer | 2004 | 15057285 | No |
| 1897 | 2100 | 1050.0 | 61.02 | 30.5 | Molecular beacons: probes that fluoresce upon hybridization. | S Tyagi, F R Kramer | Nat. Biotechnol. | 1996 | 9630890 | Yes |
| 1898 | 2100 | 1050.0 | 45.15 | 22.6 | Autophagy as a regulated pathway of cellular degradation. | D J Klionsky, S D Emr | Science | 2000 | 11099404 | No |
| 1899 | 1050 | 1050.0 | 44.09 | 44.1 | Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. | Berislav V Zlokovic | Nat. Rev. Neurosci. | 2011 | 22048062 | No |
| 1900 | 1049 | 1049.0 | 0.0 | 0.0 | A graphic method for the determination and presentation of binding parameters in a complex system. | H E Rosenthal | Anal. Biochem. | 1967 | 6048188 | Yes |
| 1901 | 1049 | 1049.0 | 28.54 | 28.5 | Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. | W D Snider | Cell | 1994 | 8205613 | No |
| 1902 | 1049 | 1049.0 | 24.91 | 24.9 | Searching for genetic determinants in the new millennium. | N J Risch | Nature | 2000 | 10866211 | No |
| 1903 | 1049 | 1049.0 | 24.95 | 24.9 | The many faces of macrophage activation. | David M Mosser | J. Leukoc. Biol. | 2003 | 12554797 | No |
| 1904 | 1049 | 1049.0 | 0.0 | 0.0 | The measurement of volume changes in human limbs. | R J WHITNEY | J. Physiol. (Lond.) | 1953 | 13085295 | Yes |
| 1905 | 2097 | 1048.5 | 42.72 | 21.4 | A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. | D Tautz, C Pfeifle | Chromosoma | 1989 | 2476281 | Yes |
| 1906 | 2097 | 1048.5 | 48.24 | 24.1 | A guided tour into subcellular colocalization analysis in light microscopy. | S Bolte, F P Cordelières | J Microsc | 2006 | 17210054 | Yes |
| 1907 | 1048 | 1048.0 | 24.04 | 24.0 | Natively unfolded proteins: a point where biology waits for physics. | Vladimir N Uversky | Protein Sci. | 2002 | 11910019 | No |
| 1908 | 2096 | 1048.0 | 0.0 | 0.0 | The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. | E G GRAY, V P WHITTAKER | J. Anat. | 1962 | 13901297 | Yes |
| 1909 | 1048 | 1048.0 | 28.39 | 28.4 | Cell signaling. H2O2, a necessary evil for cell signaling. | Sue Goo Rhee | Science | 2006 | 16809515 | Yes |
| 1910 | 1048 | 1048.0 | 44.13 | 44.1 | A Social Neuroscience Perspective on Adolescent Risk-Taking. | Laurence Steinberg | Dev Rev | 2008 | 18509515 | Yes |
| 1911 | 1048 | 1048.0 | 65.11 | 65.1 | Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. | Konrad M Andrassy | Kidney Int. | 2013 | 23989362 | Yes |
| 1912 | 2095 | 1047.5 | 51.21 | 25.6 | Liver regeneration. | G K Michalopoulos, M C DeFrances | Science | 1997 | 9082986 | No |
| 1913 | 1047 | 1047.0 | 0.0 | 0.0 | Biological applications of ionophores. | B C Pressman | Annu. Rev. Biochem. | 1976 | 786156 | No |
| 1914 | 1047 | 1047.0 | 43.43 | 43.4 | Glutathione metabolism and its selective modification. | A Meister | J. Biol. Chem. | 1988 | 3053703 | No |
| 1915 | 1047 | 1047.0 | 44.2 | 44.2 | Turnover of inositol phospholipids and signal transduction. | Y Nishizuka | Science | 1984 | 6147898 | No |
| 1916 | 1047 | 1047.0 | 56.28 | 56.3 | Negative symptoms in schizophrenia. Definition and reliability. | N C Andreasen | Arch. Gen. Psychiatry | 1982 | 7165477 | Yes |
| 1917 | 1047 | 1047.0 | 37.19 | 37.2 | Graphene transistors. | Frank Schwierz | Nat Nanotechnol | 2010 | 20512128 | Yes |
| 1918 | 2093 | 1046.5 | 114.0 | 57.0 | Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. | A Y Finlay, G K Khan | Clin. Exp. Dermatol. | 1994 | 8033378 | Yes |
| 1919 | 1045 | 1045.0 | 47.17 | 47.2 | Functional organization of central pathways regulating the cardiovascular system. | R A Dampney | Physiol. Rev. | 1994 | 8171117 | No |
| 1920 | 1045 | 1045.0 | 0.0 | 0.0 | Cognitive maps in rats and men. | E C TOLMAN | Psychol Rev | 1948 | 18870876 | Yes |
| 1921 | 1045 | 1045.0 | 0.0 | 0.0 | Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. | W C SCHNEIDER | J. Biol. Chem. | 1945 | 21005736 | Yes |
| 1922 | 1044 | 1044.0 | 70.38 | 70.4 | Conservation of resources. A new attempt at conceptualizing stress. | S E Hobfoll | Am Psychol | 1989 | 2648906 | No |
| 1923 | 2088 | 1044.0 | 60.9 | 30.4 | Pharmacology and functions of metabotropic glutamate receptors. | P J Conn, J P Pin | Annu. Rev. Pharmacol. Toxicol. | 1997 | 9131252 | No |
| 1924 | 1044 | 1044.0 | 27.71 | 27.7 | Mechanisms of foxp3+ T regulatory cell-mediated suppression. | Ethan M Shevach | Immunity | 2009 | 19464986 | No |
| 1925 | 2087 | 1043.5 | 64.04 | 32.0 | Abdominal obesity and metabolic syndrome. | Jean-Pierre Després, Isabelle Lemieux | Nature | 2006 | 17167477 | No |
| 1926 | 1043 | 1043.0 | 38.99 | 39.0 | Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. | L Bravo | Nutr. Rev. | 1998 | 9838798 | No |
| 1927 | 2085 | 1042.5 | 60.48 | 30.2 | A globally coherent fingerprint of climate change impacts across natural systems. | Camille Parmesan, Gary Yohe | Nature | 2003 | 12511946 | Yes |
| 1928 | 1042 | 1042.0 | 22.06 | 22.1 | Mobile elements: drivers of genome evolution. | Haig H Kazazian | Science | 2004 | 15016989 | No |
| 1929 | 2083 | 1041.5 | 71.62 | 35.8 | CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. | D G Higgins, P M Sharp | Gene | 1988 | 3243435 | Yes |
| 1930 | 1041 | 1041.0 | 0.0 | 0.0 | Some observations upon a new inhibitor of monoamine oxidase in brain tissue. | J P Johnston | Biochem. Pharmacol. | 1968 | 5659776 | Yes |
| 1931 | 1041 | 1041.0 | 28.63 | 28.6 | Protein kinase C: structure, function, and regulation. | A C Newton | J. Biol. Chem. | 1995 | 7499357 | No |
| 1932 | 1041 | 1041.0 | 33.6 | 33.6 | Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. | D A Dougherty | Science | 1996 | 8539615 | No |
| 1933 | 11451 | 1041.0 | 334.82 | 30.4 | New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. | P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G Gwyther | J. Natl. Cancer Inst. | 2000 | 10655437 | No |
| 1934 | 1041 | 1041.0 | 20.52 | 20.5 | The molecular motor toolbox for intracellular transport. | Ronald D Vale | Cell | 2003 | 12600311 | No |
| 1935 | 1041 | 1041.0 | 31.15 | 31.1 | Interoception: the sense of the physiological condition of the body. | A D Craig | Curr. Opin. Neurobiol. | 2003 | 12965300 | No |
| 1936 | 2080 | 1040.0 | 71.27 | 35.6 | Transforming growth factor beta in tissue fibrosis. | W A Border, N A Noble | N. Engl. J. Med. | 1994 | 7935686 | No |
| 1937 | 1040 | 1040.0 | 32.81 | 32.8 | Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. | R M Sapolsky | Arch. Gen. Psychiatry | 2000 | 11015810 | No |
| 1938 | 1040 | 1040.0 | 34.59 | 34.6 | Bioactive microbial metabolites. | János Bérdy | J. Antibiot. | 2005 | 15813176 | No |
| 1939 | 2079 | 1039.5 | 68.66 | 34.3 | Early identification of refractory epilepsy. | P Kwan, M J Brodie | N. Engl. J. Med. | 2000 | 10660394 | Yes |
| 1940 | 1039 | 1039.0 | 56.28 | 56.3 | Sample size in qualitative research. | M Sandelowski | Res Nurs Health | 1995 | 7899572 | Yes |
| 1941 | 2078 | 1039.0 | 75.77 | 37.9 | What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. | J Zhang, K F Yu | JAMA | 1998 | 9832001 | Yes |
| 1942 | 1039 | 1039.0 | 22.16 | 22.2 | CD95's deadly mission in the immune system. | P H Krammer | Nature | 2000 | 11048730 | No |
| 1943 | 3117 | 1039.0 | 72.44 | 24.1 | The versatility and universality of calcium signalling. | M J Berridge, P Lipp, M D Bootman | Nat. Rev. Mol. Cell Biol. | 2000 | 11413485 | No |
| 1944 | 2076 | 1038.0 | 0.0 | 0.0 | Regulatory sequences involved in the promotion and termination of RNA transcription. | M Rosenberg, D Court | Annu. Rev. Genet. | 1979 | 94251 | No |
| 1945 | 1038 | 1038.0 | 0.0 | 0.0 | Bias in analytic research. | D L Sackett | J Chronic Dis | 1979 | 447779 | Yes |
| 1946 | 2076 | 1038.0 | 79.4 | 39.7 | Glycine potentiates the NMDA response in cultured mouse brain neurons. | J W Johnson, P Ascher | Nature | 1987 | 2433595 | Yes |
| 1947 | 1038 | 1038.0 | 54.42 | 54.4 | The validity and practicality of sun-reactive skin types I through VI. | T B Fitzpatrick | Arch Dermatol | 1988 | 3377516 | Yes |
| 1948 | 1038 | 1038.0 | 37.26 | 37.3 | Infrared spectroscopy of proteins. | Andreas Barth | Biochim. Biophys. Acta | 2007 | 17692815 | No |
| 1949 | 2075 | 1037.5 | 0.0 | 0.0 | Empirical predictions of protein conformation. | P Y Chou, G D Fasman | Annu. Rev. Biochem. | 1978 | 354496 | No |
| 1950 | 5183 | 1036.6 | 147.01 | 29.4 | Development and testing of a general amber force field. | Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A Case | J Comput Chem | 2004 | 15116359 | Yes |
| 1951 | 2073 | 1036.5 | 58.47 | 29.2 | Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. | D A Brown, J K Rose | Cell | 1992 | 1531449 | Yes |
| 1952 | 2073 | 1036.5 | 53.15 | 26.6 | NF-kappaB: a key role in inflammatory diseases. | P P Tak, G S Firestein | J. Clin. Invest. | 2001 | 11134171 | No |
| 1953 | 3109 | 1036.3 | 99.44 | 33.1 | How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. | R M Sapolsky, L M Romero, A U Munck | Endocr. Rev. | 2000 | 10696570 | No |
| 1954 | 3109 | 1036.3 | 129.81 | 43.3 | Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. | Helga Thorvaldsdóttir, James T Robinson, Jill P Mesirov | Brief. Bioinformatics | 2013 | 22517427 | Yes |
| 1955 | 1036 | 1036.0 | 0.0 | 0.0 | Application of a Theory of Enzyme Specificity to Protein Synthesis. | D E Koshland | Proc. Natl. Acad. Sci. U.S.A. | 1958 | 16590179 | Yes |
| 1956 | 1036 | 1036.0 | 56.41 | 56.4 | Role of nrf2 in oxidative stress and toxicity. | Qiang Ma | Annu. Rev. Pharmacol. Toxicol. | 2013 | 23294312 | No |
| 1957 | 2071 | 1035.5 | 95.87 | 47.9 | The need to belong: desire for interpersonal attachments as a fundamental human motivation. | R F Baumeister, M R Leary | Psychol Bull | 1995 | 7777651 | No |
| 1958 | 2071 | 1035.5 | 55.16 | 27.6 | Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. | Jane E Visvader, Geoffrey J Lindeman | Nat. Rev. Cancer | 2008 | 18784658 | No |
| 1959 | 1035 | 1035.0 | 0.0 | 0.0 | A soluble protein characteristic of the nervous system. | B W Moore | Biochem. Biophys. Res. Commun. | 1965 | 4953930 | Yes |
| 1960 | 1035 | 1035.0 | 30.52 | 30.5 | Aspergillus fumigatus and aspergillosis. | J P Latgé | Clin. Microbiol. Rev. | 1999 | 10194462 | No |
| 1961 | 3103 | 1034.3 | 134.69 | 44.9 | Global estimates of the prevalence of diabetes for 2010 and 2030. | J E Shaw, R A Sicree, P Z Zimmet | Diabetes Res. Clin. Pract. | 2010 | 19896746 | Yes |
| 1962 | 1034 | 1034.0 | 0.0 | 0.0 | Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. | S S Lehrer | Biochemistry | 1971 | 5119250 | Yes |
| 1963 | 1034 | 1034.0 | 37.99 | 38.0 | Isolation and cultivation of Lyme disease spirochetes. | A G Barbour | Yale J Biol Med | 1984 | 6393604 | Yes |
| 1964 | 2067 | 1033.5 | 72.29 | 36.1 | Mechanisms of salinity tolerance. | Rana Munns, Mark Tester | Annu Rev Plant Biol | 2008 | 18444910 | No |
| 1965 | 1033 | 1033.0 | 40.57 | 40.6 | Ordinary magic. Resilience processes in development. | A S Masten | Am Psychol | 2001 | 11315249 | Yes |
| 1966 | 1033 | 1033.0 | 0.0 | 0.0 | DITHIOTHREITOL, A NEW PROTECTIVE REAGENT FOR SH GROUPS. | W W CLELAND | Biochemistry | 1964 | 14192894 | Yes |
| 1967 | 2066 | 1033.0 | 61.15 | 30.6 | Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. | M P Lutolf, J A Hubbell | Nat. Biotechnol. | 2005 | 15637621 | No |
| 1968 | 2065 | 1032.5 | 77.49 | 38.7 | An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. | S H Kim, J M Chung | Pain | 1992 | 1333581 | Yes |
| 1969 | 1032 | 1032.0 | 31.69 | 31.7 | Short-term synaptic plasticity. | R S Zucker | Annu. Rev. Neurosci. | 1989 | 2648947 | No |
| 1970 | 1032 | 1032.0 | 61.46 | 61.5 | A new international staging system for lung cancer. | C F Mountain | Chest | 1986 | 3514171 | No |
| 1971 | 1032 | 1032.0 | 29.69 | 29.7 | Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? | Rui Wang | FASEB J. | 2002 | 12409322 | Yes |
| 1972 | 1031 | 1031.0 | 38.33 | 38.3 | Integrins. | E Ruoslahti | J. Clin. Invest. | 1991 | 1985087 | No |
| 1973 | 1031 | 1031.0 | 57.12 | 57.1 | Cyclosporine. | B D Kahan | N. Engl. J. Med. | 1989 | 2687689 | No |
| 1974 | 2062 | 1031.0 | 71.68 | 35.8 | Epidemiology of invasive candidiasis: a persistent public health problem. | M A Pfaller, D J Diekema | Clin. Microbiol. Rev. | 2007 | 17223626 | No |
| 1975 | 1031 | 1031.0 | 0.0 | 0.0 | A new specific color reaction of hexuronic acids. | Z DISCHE | J. Biol. Chem. | 1947 | 20281638 | Yes |
| 1976 | 3093 | 1031.0 | 147.21 | 49.1 | featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. | Yang Liao, Gordon K Smyth, Wei Shi | Bioinformatics | 2014 | 24227677 | Yes |
| 1977 | 1030 | 1030.0 | 0.0 | 0.0 | Calcium release from the sarcoplasmic reticulum. | M Endo | Physiol. Rev. | 1977 | 13441 | Yes |
| 1978 | 3090 | 1030.0 | 106.5 | 35.5 | A rapid bootstrap algorithm for the RAxML Web servers. | Alexandros Stamatakis, Paul Hoover, Jacques Rougemont | Syst. Biol. | 2008 | 18853362 | Yes |
| 1979 | 2059 | 1029.5 | 83.19 | 41.6 | Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. | D S Bredt, S H Snyder | Proc. Natl. Acad. Sci. U.S.A. | 1990 | 1689048 | Yes |
| 1980 | 1029 | 1029.0 | 28.23 | 28.2 | Codon usage and tRNA content in unicellular and multicellular organisms. | T Ikemura | Mol. Biol. Evol. | 1985 | 3916708 | No |
| 1981 | 1029 | 1029.0 | 35.37 | 35.4 | Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. | P Willner | Psychopharmacology (Berl.) | 1997 | 9452163 | No |
| 1982 | 1029 | 1029.0 | 31.66 | 31.7 | Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. | Y Shai | Biochim. Biophys. Acta | 1999 | 10590302 | No |
| 1983 | 4112 | 1028.0 | 109.59 | 27.4 | Base-calling of automated sequencer traces using phred. I. Accuracy assessment. | B Ewing, L Hillier, M C Wendl, P Green | Genome Res. | 1998 | 9521921 | Yes |
| 1984 | 1028 | 1028.0 | 43.06 | 43.1 | The polyvagal perspective. | Stephen W Porges | Biol Psychol | 2007 | 17049418 | No |
| 1985 | 1028 | 1028.0 | 30.21 | 30.2 | Marine viruses--major players in the global ecosystem. | Curtis A Suttle | Nat. Rev. Microbiol. | 2007 | 17853907 | No |
| 1986 | 2055 | 1027.5 | 55.62 | 27.8 | The RXR heterodimers and orphan receptors. | D J Mangelsdorf, R M Evans | Cell | 1995 | 8521508 | No |
| 1987 | 1027 | 1027.0 | 38.36 | 38.4 | The many roles for fluorine in medicinal chemistry. | William K Hagmann | J. Med. Chem. | 2008 | 18570365 | Yes |
| 1988 | 1027 | 1027.0 | 38.99 | 39.0 | Stress signalling pathways that impair prefrontal cortex structure and function. | Amy F T Arnsten | Nat. Rev. Neurosci. | 2009 | 19455173 | No |
| 1989 | 1027 | 1027.0 | 46.2 | 46.2 | Large-scale brain networks and psychopathology: a unifying triple network model. | Vinod Menon | Trends Cogn. Sci. (Regul. Ed.) | 2011 | 21908230 | No |
| 1990 | 1026 | 1026.0 | 34.13 | 34.1 | A more meaningful scoring system for determining the severity of coronary heart disease. | G G Gensini | Am. J. Cardiol. | 1983 | 6823874 | Yes |
| 1991 | 2051 | 1025.5 | 0.0 | 0.0 | A general method for isolation of high molecular weight DNA from eukaryotes. | N Blin, D W Stafford | Nucleic Acids Res. | 1976 | 987581 | Yes |
| 1992 | 1025 | 1025.0 | 0.0 | 0.0 | The ultrastructural basis of capillary permeability studied with peroxidase as a tracer. | M J Karnovsky | J. Cell Biol. | 1967 | 6061717 | Yes |
| 1993 | 1025 | 1025.0 | 23.08 | 23.1 | The significance of responses of the genome to challenge. | B McClintock | Science | 1984 | 15739260 | No |
| 1994 | 2049 | 1024.5 | 61.99 | 31.0 | The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. | Daniel J Drucker, Michael A Nauck | Lancet | 2006 | 17098089 | No |
| 1995 | 2049 | 1024.5 | 73.31 | 36.7 | Protective and pathogenic functions of macrophage subsets. | Peter J Murray, Thomas A Wynn | Nat. Rev. Immunol. | 2011 | 21997792 | No |
| 1996 | 1024 | 1024.0 | 20.45 | 20.4 | c-Myc target genes involved in cell growth, apoptosis, and metabolism. | C V Dang | Mol. Cell. Biol. | 1999 | 9858526 | No |
| 1997 | 1024 | 1024.0 | 30.47 | 30.5 | Tobacco smoke carcinogens and lung cancer. | S S Hecht | J. Natl. Cancer Inst. | 1999 | 10413421 | No |
| 1998 | 1024 | 1024.0 | 25.13 | 25.1 | The stem-cell niche as an entity of action. | David T Scadden | Nature | 2006 | 16810242 | No |
| 1999 | 2048 | 1024.0 | 70.84 | 35.4 | CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. | Mattias Jakobsson, Noah A Rosenberg | Bioinformatics | 2007 | 17485429 | Yes |
| 2000 | 1023 | 1023.0 | 32.26 | 32.3 | Speculations on the functions of the major heat shock and glucose-regulated proteins. | H R Pelham | Cell | 1986 | 2944601 | Yes |
| 2001 | 1023 | 1023.0 | 39.24 | 39.2 | Osteoblast adhesion on biomaterials. | K Anselme | Biomaterials | 2000 | 10711964 | No |
| 2002 | 2046 | 1023.0 | 41.51 | 20.8 | DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. | Christopher J Bakkenist, Michael B Kastan | Nature | 2003 | 12556884 | Yes |
| 2003 | 2044 | 1022.0 | 59.22 | 29.6 | Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. | M Zuker, P Stiegler | Nucleic Acids Res. | 1981 | 6163133 | Yes |
| 2004 | 3065 | 1021.7 | 95.15 | 31.7 | The metabolic syndrome. | Robert H Eckel, Scott M Grundy, Paul Z Zimmet | Lancet | 2005 | 15836891 | No |
| 2005 | 2042 | 1021.0 | 56.48 | 28.2 | Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. | M E Greenberg, E B Ziff | Nature | 1984 | 6090941 | Yes |
| 2006 | 1021 | 1021.0 | 29.82 | 29.8 | Two pathogenetic types of endometrial carcinoma. | J V Bokhman | Gynecol. Oncol. | 1983 | 6822361 | Yes |
| 2007 | 1021 | 1021.0 | 25.27 | 25.3 | Dimerization of cell surface receptors in signal transduction. | C H Heldin | Cell | 1995 | 7834741 | No |
| 2008 | 3063 | 1021.0 | 81.25 | 27.1 | Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? | Witold Filipowicz, Suvendra N Bhattacharyya, Nahum Sonenberg | Nat. Rev. Genet. | 2008 | 18197166 | No |
| 2009 | 2041 | 1020.5 | 53.43 | 26.7 | Mitochondrial control of cell death. | G Kroemer, J C Reed | Nat. Med. | 2000 | 10802706 | No |
| 2010 | 1020 | 1020.0 | 0.0 | 0.0 | CHEMOAFFINITY IN THE ORDERLY GROWTH OF NERVE FIBER PATTERNS AND CONNECTIONS. | R W SPERRY | Proc. Natl. Acad. Sci. U.S.A. | 1963 | 14077501 | Yes |
| 2011 | 1020 | 1020.0 | 31.55 | 31.6 | Microbial influences in inflammatory bowel diseases. | R Balfour Sartor | Gastroenterology | 2008 | 18242222 | No |
| 2012 | 2037 | 1018.5 | 51.61 | 25.8 | Cellular senescence: when bad things happen to good cells. | Judith Campisi, Fabrizio d'Adda di Fagagna | Nat. Rev. Mol. Cell Biol. | 2007 | 17667954 | No |
| 2013 | 1018 | 1018.0 | 0.0 | 0.0 | Hippocampal electrical activity and voluntary movement in the rat. | C H Vanderwolf | Electroencephalogr Clin Neurophysiol | 1969 | 4183562 | Yes |
| 2014 | 1018 | 1018.0 | 49.02 | 49.0 | Presidential address, 1980. Surprise!...Surprise? | E Donchin | Psychophysiology | 1981 | 7280146 | Yes |
| 2015 | 1018 | 1018.0 | 33.2 | 33.2 | Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. | Arnold I Caplan | J. Cell. Physiol. | 2007 | 17620285 | No |
| 2016 | 3053 | 1017.7 | 99.7 | 33.2 | Atomic force microscope. | Binnig, Quate, Gerber | Phys. Rev. Lett. | 1986 | 10033323 | Yes |
| 2017 | 1017 | 1017.0 | 0.0 | 0.0 | Carbonic anhydrase: chemistry, physiology, and inhibition. | T H Maren | Physiol. Rev. | 1967 | 4964060 | No |
| 2018 | 1017 | 1017.0 | 0.0 | 0.0 | Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. | C S Neer | J Bone Joint Surg Am | 1972 | 5054450 | Yes |
| 2019 | 1016 | 1016.0 | 52.75 | 52.8 | Reliability and factor analysis of the Epworth Sleepiness Scale. | M W Johns | Sleep | 1992 | 1519015 | Yes |
| 2020 | 1016 | 1016.0 | 0.0 | 0.0 | The biologic clock: the mitochondria? | D Harman | J Am Geriatr Soc | 1972 | 5016631 | Yes |
| 2021 | 1016 | 1016.0 | 48.24 | 48.2 | Colorimetric determination of phospholipids with ammonium ferrothiocyanate. | J C Stewart | Anal. Biochem. | 1980 | 6892980 | Yes |
| 2022 | 2032 | 1016.0 | 46.16 | 23.1 | Gene silencing in cancer in association with promoter hypermethylation. | James G Herman, Stephen B Baylin | N. Engl. J. Med. | 2003 | 14627790 | No |
| 2023 | 1016 | 1016.0 | 30.94 | 30.9 | The human orbitofrontal cortex: linking reward to hedonic experience. | Morten L Kringelbach | Nat. Rev. Neurosci. | 2005 | 16136173 | No |
| 2024 | 2030 | 1015.0 | 67.66 | 33.8 | Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. | C Auffray, F Rougeon | Eur. J. Biochem. | 1980 | 6772444 | Yes |
| 2025 | 2030 | 1015.0 | 57.49 | 28.7 | Integrins and signal transduction pathways: the road taken. | E A Clark, J S Brugge | Science | 1995 | 7716514 | No |
| 2026 | 2030 | 1015.0 | 68.88 | 34.4 | Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. | F D Lublin, S C Reingold | Neurology | 1996 | 8780061 | Yes |
| 2027 | 1015 | 1015.0 | 37.54 | 37.5 | Chronic disease management: what will it take to improve care for chronic illness? | E H Wagner | Eff Clin Pract | 1998 | 10345255 | No |
| 2028 | 1015 | 1015.0 | 40.26 | 40.3 | The law of attrition. | Gunther Eysenbach | J. Med. Internet Res. | 2005 | 15829473 | Yes |
| 2029 | 1015 | 1015.0 | 30.88 | 30.9 | Pathogen recognition and inflammatory signaling in innate immune defenses. | Trine H Mogensen | Clin. Microbiol. Rev. | 2009 | 19366914 | No |
| 2030 | 6088 | 1014.7 | 179.62 | 29.9 | A default mode of brain function. | M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L Shulman | Proc. Natl. Acad. Sci. U.S.A. | 2001 | 11209064 | Yes |
| 2031 | 2029 | 1014.5 | 76.9 | 38.5 | Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. | D Filmer, L H Pritchett | Demography | 2001 | 11227840 | Yes |
| 2032 | 2029 | 1014.5 | 91.78 | 45.9 | Microenvironmental regulation of tumor progression and metastasis. | Daniela F Quail, Johanna A Joyce | Nat. Med. | 2013 | 24202395 | No |
| 2033 | 9124 | 1013.8 | 373.72 | 41.5 | The 1982 revised criteria for the classification of systemic lupus erythematosus. | E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J Winchester | Arthritis Rheum. | 1982 | 7138600 | Yes |
| 2034 | 2027 | 1013.5 | 56.05 | 28.0 | The DNA damage response: making it safe to play with knives. | Alberto Ciccia, Stephen J Elledge | Mol. Cell | 2010 | 20965415 | No |
| 2035 | 1013 | 1013.0 | 32.14 | 32.1 | The importance of the ratio of omega-6/omega-3 essential fatty acids. | A P Simopoulos | Biomed. Pharmacother. | 2002 | 12442909 | No |
| 2036 | 2026 | 1013.0 | 84.91 | 42.5 | Saliency, switching, attention and control: a network model of insula function. | Vinod Menon, Lucina Q Uddin | Brain Struct Funct | 2010 | 20512370 | No |
| 2037 | 3037 | 1012.3 | 100.69 | 33.6 | Regularization Paths for Generalized Linear Models via Coordinate Descent. | Jerome Friedman, Trevor Hastie, Rob Tibshirani | J Stat Softw | 2010 | 20808728 | Yes |
| 2038 | 4049 | 1012.2 | 148.05 | 37.0 | Reversible middle cerebral artery occlusion without craniectomy in rats. | E Z Longa, P R Weinstein, S Carlson, R Cummins | Stroke | 1989 | 2643202 | Yes |
| 2039 | 1012 | 1012.0 | 39.27 | 39.3 | Biological basis of the behavior of sick animals. | B L Hart | Neurosci Biobehav Rev | 1988 | 3050629 | No |
| 2040 | 1012 | 1012.0 | 40.69 | 40.7 | Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. | A E Pegg | Cancer Res. | 1988 | 3123052 | No |
| 2041 | 1012 | 1012.0 | 0.0 | 0.0 | A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. | M G BUONOCORE | J. Dent. Res. | 1955 | 13271655 | Yes |
| 2042 | 3035 | 1011.7 | 0.0 | 0.0 | The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. | J T DODGE, C MITCHELL, D J HANAHAN | Arch. Biochem. Biophys. | 1963 | 14028302 | Yes |
| 2043 | 5057 | 1011.4 | 185.63 | 37.1 | Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. | Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E Walters | Arch. Gen. Psychiatry | 2005 | 15939839 | Yes |
| 2044 | 2022 | 1011.0 | 61.82 | 30.9 | Rising incidence of hepatocellular carcinoma in the United States. | H B El-Serag, A C Mason | N. Engl. J. Med. | 1999 | 10072408 | Yes |
| 2045 | 2021 | 1010.5 | 41.85 | 20.9 | Live or let die: the cell's response to p53. | Karen H Vousden, Xin Lu | Nat. Rev. Cancer | 2002 | 12154352 | No |
| 2046 | 2021 | 1010.5 | 47.28 | 23.6 | Regulated portals of entry into the cell. | Sean D Conner, Sandra L Schmid | Nature | 2003 | 12621426 | No |
| 2047 | 4042 | 1010.5 | 166.02 | 41.5 | A brief measure for assessing generalized anxiety disorder: the GAD-7. | Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd Löwe | Arch. Intern. Med. | 2006 | 16717171 | Yes |
| 2048 | 1010 | 1010.0 | 35.24 | 35.2 | Rheumatoid arthritis. Pathophysiology and implications for therapy. | E D Harris | N. Engl. J. Med. | 1990 | 2271017 | No |
| 2049 | 2020 | 1010.0 | 60.54 | 30.3 | The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. | Clay B Holroyd, Michael G H Coles | Psychol Rev | 2002 | 12374324 | Yes |
| 2050 | 1010 | 1010.0 | 30.5 | 30.5 | The hydrogen bond in the solid state. | Thomas Steiner | Angew. Chem. Int. Ed. Engl. | 2002 | 12491444 | Yes |
| 2051 | 1009 | 1009.0 | 39.43 | 39.4 | Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. | A A Grace | Neuroscience | 1991 | 1676137 | No |
| 2052 | 1009 | 1009.0 | 40.96 | 41.0 | Equipoise and the ethics of clinical research. | B Freedman | N. Engl. J. Med. | 1987 | 3600702 | Yes |
| 2053 | 1009 | 1009.0 | 18.03 | 18.0 | Themes and variations on ubiquitylation. | A M Weissman | Nat. Rev. Mol. Cell Biol. | 2001 | 11265246 | No |
| 2054 | 3026 | 1008.7 | 139.54 | 46.5 | CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. | Teresa C Horan, Mary Andrus, Margaret A Dudeck | Am J Infect Control | 2008 | 18538699 | No |
| 2055 | 2017 | 1008.5 | 54.21 | 27.1 | Disruption of epithelial cell-matrix interactions induces apoptosis. | S M Frisch, H Francis | J. Cell Biol. | 1994 | 8106557 | Yes |
| 2056 | 6049 | 1008.2 | 200.25 | 33.4 | Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. | Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur Wheeler | N. Engl. J. Med. | 2000 | 10793162 | Yes |
| 2057 | 1008 | 1008.0 | 39.52 | 39.5 | Pathogenetic mechanisms of septic shock. | J E Parrillo | N. Engl. J. Med. | 1993 | 8479467 | No |
| 2058 | 1008 | 1008.0 | 29.94 | 29.9 | Papillomavirus infections--a major cause of human cancers. | H zur Hausen | Biochim. Biophys. Acta | 1996 | 8876633 | No |
| 2059 | 11088 | 1008.0 | 378.96 | 34.5 | The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. | Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J Roccella | JAMA | 2003 | 12748199 | No |
| 2060 | 1007 | 1007.0 | 0.0 | 0.0 | Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. | K S McCully | Am. J. Pathol. | 1969 | 5792556 | Yes |
| 2061 | 1007 | 1007.0 | 0.0 | 0.0 | On the law of effect. | R J Herrnstein | J Exp Anal Behav | 1970 | 16811440 | Yes |
| 2062 | 5032 | 1006.4 | 151.29 | 30.3 | Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. | Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory Collins | Lancet | 2002 | 12493255 | Yes |
| 2063 | 1006 | 1006.0 | 26.67 | 26.7 | Double identity for proteins of the Bcl-2 family. | J C Reed | Nature | 1997 | 9194558 | No |
| 2064 | 3017 | 1005.7 | 131.23 | 43.7 | A new method for off-line removal of ocular artifact. | G Gratton, M G Coles, E Donchin | Electroencephalogr Clin Neurophysiol | 1983 | 6187540 | Yes |
| 2065 | 2011 | 1005.5 | 89.68 | 44.8 | Universal chemical assay for the detection and determination of siderophores. | B Schwyn, J B Neilands | Anal. Biochem. | 1987 | 2952030 | Yes |
| 2066 | 2011 | 1005.5 | 74.15 | 37.1 | Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. | D Marion, K Wüthrich | Biochem. Biophys. Res. Commun. | 1983 | 6307308 | Yes |
| 2067 | 2011 | 1005.5 | 61.2 | 30.6 | Neuronal plasticity: increasing the gain in pain. | C J Woolf, M W Salter | Science | 2000 | 10846153 | No |
| 2068 | 3015 | 1005.0 | 0.0 | 0.0 | A highly sensitive adenylate cyclase assay. | Y Salomon, C Londos, M Rodbell | Anal. Biochem. | 1974 | 4827395 | Yes |
| 2069 | 1005 | 1005.0 | 0.0 | 0.0 | Codon--anticodon pairing: the wobble hypothesis. | F H Crick | J. Mol. Biol. | 1966 | 5969078 | Yes |
| 2070 | 2010 | 1005.0 | 69.08 | 34.5 | Bronchopulmonary dysplasia. | A H Jobe, E Bancalari | Am. J. Respir. Crit. Care Med. | 2001 | 11401896 | No |
| 2071 | 1005 | 1005.0 | 34.19 | 34.2 | Polycystic ovary syndrome. | David A Ehrmann | N. Engl. J. Med. | 2005 | 15788499 | No |
| 2072 | 7034 | 1004.9 | 156.63 | 22.4 | Exploration, normalization, and summaries of high density oligonucleotide array probe level data. | Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P Speed | Biostatistics | 2003 | 12925520 | Yes |
| 2073 | 1004 | 1004.0 | 71.02 | 71.0 | The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. | G A Ilizarov | Clin. Orthop. Relat. Res. | 1989 | 2910611 | Yes |
| 2074 | 3010 | 1003.3 | 124.33 | 41.4 | Factor structure of the Barratt impulsiveness scale. | J H Patton, M S Stanford, E S Barratt | J Clin Psychol | 1995 | 8778124 | Yes |
| 2075 | 1003 | 1003.0 | 28.61 | 28.6 | Reactive oxygen radicals in signaling and damage in the ischemic brain. | P H Chan | J. Cereb. Blood Flow Metab. | 2001 | 11149664 | No |
| 2076 | 1003 | 1003.0 | 28.7 | 28.7 | Upconversion and anti-Stokes processes with f and d ions in solids. | François Auzel | Chem. Rev. | 2004 | 14719973 | Yes |
| 2077 | 2006 | 1003.0 | 66.92 | 33.5 | Molecular replacement with MOLREP. | Alexei Vagin, Alexei Teplyakov | Acta Crystallogr. D Biol. Crystallogr. | 2010 | 20057045 | Yes |
| 2078 | 1002 | 1002.0 | 46.89 | 46.9 | Serum albumin. | T Peters | Adv. Protein Chem. | 1985 | 3904348 | No |
| 2079 | 2004 | 1002.0 | 83.87 | 41.9 | Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. | M M Bradley, P J Lang | J Behav Ther Exp Psychiatry | 1994 | 7962581 | Yes |
| 2080 | 2004 | 1002.0 | 83.9 | 42.0 | Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. | J W Vlaeyen, S J Linton | Pain | 2000 | 10781906 | No |
| 2081 | 1002 | 1002.0 | 31.77 | 31.8 | The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. | T Szkudelski | Physiol Res | 2001 | 11829314 | No |
| 2082 | 1001 | 1001.0 | 24.32 | 24.3 | Caspase structure, proteolytic substrates, and function during apoptotic cell death. | D W Nicholson | Cell Death Differ. | 1999 | 10578171 | No |
| 2083 | 2001 | 1000.5 | 112.38 | 56.2 | Natural products as sources of new drugs over the 30 years from 1981 to 2010. | David J Newman, Gordon M Cragg | J. Nat. Prod. | 2012 | 22316239 | No |
| 2084 | 1000 | 1000.0 | 31.71 | 31.7 | The aryl hydrocarbon receptor complex. | O Hankinson | Annu. Rev. Pharmacol. Toxicol. | 1995 | 7598497 | No |
| 2085 | 3000 | 1000.0 | 104.06 | 34.7 | I-TASSER: a unified platform for automated protein structure and function prediction. | Ambrish Roy, Alper Kucukural, Yang Zhang | Nat Protoc | 2010 | 20360767 | Yes |
| 2086 | 1999 | 999.5 | 61.38 | 30.7 | Macrophage diversity enhances tumor progression and metastasis. | Bin-Zhi Qian, Jeffrey W Pollard | Cell | 2010 | 20371344 | No |
| 2087 | 999 | 999.0 | 34.0 | 34.0 | Type I diabetes mellitus. A chronic autoimmune disease. | G S Eisenbarth | N. Engl. J. Med. | 1986 | 3517648 | No |
| 2088 | 1998 | 999.0 | 50.36 | 25.2 | The pathophysiology of mitochondrial cell death. | Douglas R Green, Guido Kroemer | Science | 2004 | 15286356 | No |
| 2089 | 1997 | 998.5 | 0.0 | 0.0 | Mutants of Escherichia coli requiring methionine or vitamin B12. | B D DAVIS, E S MINGIOLI | J. Bacteriol. | 1950 | 15436457 | Yes |
| 2090 | 1996 | 998.0 | 65.7 | 32.9 | What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? | K C Berridge, T E Robinson | Brain Res. Brain Res. Rev. | 1998 | 9858756 | No |
| 2091 | 3992 | 998.0 | 91.25 | 22.8 | Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. | D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini | Science | 2005 | 15718470 | Yes |
| 2092 | 1996 | 998.0 | 59.38 | 29.7 | Powering the planet: chemical challenges in solar energy utilization. | Nathan S Lewis, Daniel G Nocera | Proc. Natl. Acad. Sci. U.S.A. | 2006 | 17043226 | Yes |
| 2093 | 997 | 997.0 | 33.31 | 33.3 | Cellular oncogenes and retroviruses. | J M Bishop | Annu. Rev. Biochem. | 1983 | 6351725 | No |
| 2094 | 997 | 997.0 | 0.0 | 0.0 | The etiology of chondromalacia patellae. | R E OUTERBRIDGE | J Bone Joint Surg Br | 1961 | 14038135 | Yes |
| 2095 | 997 | 997.0 | 27.56 | 27.6 | Fast and robust fixed-point algorithms for independent component analysis. | A Hyvärinen | IEEE Trans Neural Netw | 1999 | 18252563 | Yes |
| 2096 | 3988 | 997.0 | 210.99 | 52.7 | Bayesian phylogenetics with BEAUti and the BEAST 1.7. | Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew Rambaut | Mol. Biol. Evol. | 2012 | 22367748 | Yes |
| 2097 | 1993 | 996.5 | 53.99 | 27.0 | Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. | M Fried, D M Crothers | Nucleic Acids Res. | 1981 | 6275366 | Yes |
| 2098 | 996 | 996.0 | 0.0 | 0.0 | Cerebral blood flow and oxygen consumption in man. | N A LASSEN | Physiol. Rev. | 1959 | 13645234 | Yes |
| 2099 | 996 | 996.0 | 33.68 | 33.7 | The sympathetic control of blood pressure. | Patrice G Guyenet | Nat. Rev. Neurosci. | 2006 | 16760914 | No |
| 2100 | 995 | 995.0 | 40.97 | 41.0 | Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. | Chao-Jun Li | Acc. Chem. Res. | 2009 | 19220064 | Yes |
| 2101 | 1990 | 995.0 | 56.3 | 28.1 | Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. | Kornelia Polyak, Robert A Weinberg | Nat. Rev. Cancer | 2009 | 19262571 | No |
| 2102 | 994 | 994.0 | 31.53 | 31.5 | VLA proteins in the integrin family: structures, functions, and their role on leukocytes. | M E Hemler | Annu. Rev. Immunol. | 1990 | 2188667 | No |
| 2103 | 994 | 994.0 | 36.2 | 36.2 | Treatment of infections associated with surgical implants. | Rabih O Darouiche | N. Engl. J. Med. | 2004 | 15070792 | No |
| 2104 | 1987 | 993.5 | 38.67 | 19.3 | The DNA damage response: putting checkpoints in perspective. | B B Zhou, S J Elledge | Nature | 2000 | 11100718 | No |
| 2105 | 993 | 993.0 | 0.0 | 0.0 | Atherogenesis: a postprandial phenomenon. | D B Zilversmit | Circulation | 1979 | 222498 | Yes |
| 2106 | 993 | 993.0 | 51.04 | 51.0 | Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. | A H Conney | Cancer Res. | 1982 | 6814745 | No |
| 2107 | 992 | 992.0 | 38.12 | 38.1 | Classification of chronic viral hepatitis: a need for reassessment. | P J Scheuer | J. Hepatol. | 1991 | 1808228 | No |
| 2108 | 992 | 992.0 | 0.0 | 0.0 | Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. | W D Hamilton | Science | 1967 | 6021675 | Yes |
| 2109 | 992 | 992.0 | 44.52 | 44.5 | The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. | E J Khantzian | Harv Rev Psychiatry | 1997 | 9385000 | No |
| 2110 | 1983 | 991.5 | 59.06 | 29.5 | The free radical theory of aging matures. | K B Beckman, B N Ames | Physiol. Rev. | 1998 | 9562038 | No |
| 2111 | 991 | 991.0 | 25.79 | 25.8 | S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. | R Donato | Int. J. Biochem. Cell Biol. | 2001 | 11390274 | No |
| 2112 | 991 | 991.0 | 20.13 | 20.1 | microRNAs: tiny regulators with great potential. | V Ambros | Cell | 2001 | 11779458 | No |
| 2113 | 3963 | 990.8 | 105.47 | 26.4 | Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. | Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J Thun | N. Engl. J. Med. | 2003 | 12711737 | Yes |
| 2114 | 1981 | 990.5 | 51.11 | 25.6 | Self-assembly at all scales. | George M Whitesides, Bartosz Grzybowski | Science | 2002 | 11923529 | Yes |
| 2115 | 990 | 990.0 | 0.0 | 0.0 | The origin of the genetic code. | F H Crick | J. Mol. Biol. | 1968 | 4887876 | Yes |
| 2116 | 990 | 990.0 | 66.33 | 66.3 | Subjective well-being. | E Diener | Psychol Bull | 1984 | 6399758 | No |
| 2117 | 990 | 990.0 | 42.47 | 42.5 | Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. | S Hakomori | Annu. Rev. Biochem. | 1981 | 7023369 | No |
| 2118 | 990 | 990.0 | 30.17 | 30.2 | Rapid evolution of a protein in vitro by DNA shuffling. | W P Stemmer | Nature | 1994 | 8047147 | Yes |
| 2119 | 990 | 990.0 | 35.86 | 35.9 | Invasive aspergillosis. | D W Denning | Clin. Infect. Dis. | 1998 | 9564455 | No |
| 2120 | 1979 | 989.5 | 47.24 | 23.6 | ERBB receptors and cancer: the complexity of targeted inhibitors. | Nancy E Hynes, Heidi A Lane | Nat. Rev. Cancer | 2005 | 15864276 | No |
| 2121 | 1979 | 989.5 | 71.74 | 35.9 | A perspective on cancer cell metastasis. | Christine L Chaffer, Robert A Weinberg | Science | 2011 | 21436443 | No |
| 2122 | 3956 | 989.0 | 0.0 | 0.0 | Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. | D W Cleveland, S G Fischer, M W Kirschner, U K Laemmli | J. Biol. Chem. | 1977 | 320200 | Yes |
| 2123 | 989 | 989.0 | 33.65 | 33.6 | Cell and environment interactions in tumor microregions: the multicell spheroid model. | R M Sutherland | Science | 1988 | 2451290 | Yes |
| 2124 | 989 | 989.0 | 32.81 | 32.8 | Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. | U Mitzdorf | Physiol. Rev. | 1985 | 3880898 | No |
| 2125 | 989 | 989.0 | 33.38 | 33.4 | Diagnosis of osteoporosis and assessment of fracture risk. | John A Kanis | Lancet | 2002 | 12057569 | No |
| 2126 | 989 | 989.0 | 36.15 | 36.1 | Semiempirical hybrid density functional with perturbative second-order correlation. | Stefan Grimme | J Chem Phys | 2006 | 16438568 | Yes |
| 2127 | 1977 | 988.5 | 45.22 | 22.6 | Molecular chaperones in the cytosol: from nascent chain to folded protein. | F Ulrich Hartl, Manajit Hayer-Hartl | Science | 2002 | 11884745 | No |
| 2128 | 5929 | 988.2 | 126.11 | 21.0 | Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. | S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T Tuschl | Nature | 2001 | 11373684 | Yes |
| 2129 | 987 | 987.0 | 34.33 | 34.3 | Varieties of impulsivity. | J L Evenden | Psychopharmacology (Berl.) | 1999 | 10550486 | No |
| 2130 | 1974 | 987.0 | 92.48 | 46.2 | The Oswestry Disability Index. | J C Fairbank, P B Pynsent | Spine | 2000 | 11074683 | No |
| 2131 | 987 | 987.0 | 0.0 | 0.0 | Modality and topographic properties of single neurons of cat's somatic sensory cortex. | V B MOUNTCASTLE | J. Neurophysiol. | 1957 | 13439410 | Yes |
| 2132 | 987 | 987.0 | 21.93 | 21.9 | IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. | Yong-Jun Liu | Annu. Rev. Immunol. | 2005 | 15771572 | No |
| 2133 | 2958 | 986.0 | 0.0 | 0.0 | Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. | J Garnier, D J Osguthorpe, B Robson | J. Mol. Biol. | 1978 | 642007 | Yes |
| 2134 | 1972 | 986.0 | 49.97 | 25.0 | Adaptive protein evolution at the Adh locus in Drosophila. | J H McDonald, M Kreitman | Nature | 1991 | 1904993 | Yes |
| 2135 | 986 | 986.0 | 0.0 | 0.0 | The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. | A G Pearse | J. Histochem. Cytochem. | 1969 | 4143745 | No |
| 2136 | 986 | 986.0 | 22.26 | 22.3 | Lipid rafts: elusive or illusive? | Sean Munro | Cell | 2003 | 14622593 | No |
| 2137 | 986 | 986.0 | 25.07 | 25.1 | Long-term potentiation and memory. | M A Lynch | Physiol. Rev. | 2004 | 14715912 | No |
| 2138 | 985 | 985.0 | 19.26 | 19.3 | Cancer susceptibility and the functions of BRCA1 and BRCA2. | Ashok R Venkitaraman | Cell | 2002 | 11832208 | No |
| 2139 | 985 | 985.0 | 0.0 | 0.0 | Diversity in tropical rain forests and coral reefs. | J H Connell | Science | 1978 | 17840770 | Yes |
| 2140 | 4922 | 984.4 | 251.9 | 50.4 | UCHIME improves sensitivity and speed of chimera detection. | Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob Knight | Bioinformatics | 2011 | 21700674 | Yes |
| 2141 | 2953 | 984.3 | 182.23 | 60.7 | Risk factors for falls among elderly persons living in the community. | M E Tinetti, M Speechley, S F Ginter | N. Engl. J. Med. | 1988 | 3205267 | Yes |
| 2142 | 984 | 984.0 | 20.08 | 20.1 | Kinesin and dynein superfamily proteins and the mechanism of organelle transport. | N Hirokawa | Science | 1998 | 9438838 | No |
| 2143 | 983 | 983.0 | 28.89 | 28.9 | Clinical features of metastatic bone disease and risk of skeletal morbidity. | Robert E Coleman | Clin. Cancer Res. | 2006 | 17062708 | No |
| 2144 | 3931 | 982.8 | 96.18 | 24.0 | Interleukin-10 and the interleukin-10 receptor. | K W Moore, R de Waal Malefyt, R L Coffman, A O'Garra | Annu. Rev. Immunol. | 2001 | 11244051 | No |
| 2145 | 3931 | 982.8 | 179.16 | 44.8 | Prevalence and trends in obesity among US adults, 1999-2008. | Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R Curtin | JAMA | 2010 | 20071471 | Yes |
| 2146 | 1965 | 982.5 | 71.84 | 35.9 | Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. | James J Gross, Oliver P John | J Pers Soc Psychol | 2003 | 12916575 | Yes |
| 2147 | 982 | 982.0 | 0.0 | 0.0 | Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. | H S Penefsky | J. Biol. Chem. | 1977 | 16006 | Yes |
| 2148 | 1964 | 982.0 | 47.24 | 23.6 | CpG islands in vertebrate genomes. | M Gardiner-Garden, M Frommer | J. Mol. Biol. | 1987 | 3656447 | Yes |
| 2149 | 982 | 982.0 | 28.44 | 28.4 | Proinflammatory cytokines. | C A Dinarello | Chest | 2000 | 10936147 | No |
| 2150 | 981 | 981.0 | 38.84 | 38.8 | An application of prefrontal cortex function theory to cognitive aging. | R L West | Psychol Bull | 1996 | 8831298 | No |
| 2151 | 1962 | 981.0 | 40.46 | 20.2 | The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. | T Maehama, J E Dixon | J. Biol. Chem. | 1998 | 9593664 | Yes |
| 2152 | 1962 | 981.0 | 63.56 | 31.8 | The gut microbiota shapes intestinal immune responses during health and disease. | June L Round, Sarkis K Mazmanian | Nat. Rev. Immunol. | 2009 | 19343057 | No |
| 2153 | 2941 | 980.3 | 82.57 | 27.5 | Global and societal implications of the diabetes epidemic. | P Zimmet, K G Alberti, J Shaw | Nature | 2001 | 11742409 | No |
| 2154 | 2940 | 980.0 | 183.14 | 61.0 | In search of how people change. Applications to addictive behaviors. | J O Prochaska, C C DiClemente, J C Norcross | Am Psychol | 1992 | 1329589 | Yes |
| 2155 | 980 | 980.0 | 47.72 | 47.7 | Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). | G G Glenner | N. Engl. J. Med. | 1980 | 6154243 | No |
| 2156 | 1959 | 979.5 | 0.0 | 0.0 | Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. | J E Sulston, H R Horvitz | Dev. Biol. | 1977 | 838129 | Yes |
| 2157 | 5876 | 979.3 | 258.13 | 43.0 | TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. | Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg | Genome Biol. | 2013 | 23618408 | Yes |
| 2158 | 1958 | 979.0 | 0.0 | 0.0 | Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. | D B Dill, D L Costill | J Appl Physiol | 1974 | 4850854 | Yes |
| 2159 | 979 | 979.0 | 42.53 | 42.5 | Inhibition and facilitation of nucleic acid amplification. | I G Wilson | Appl. Environ. Microbiol. | 1997 | 9327537 | No |
| 2160 | 979 | 979.0 | 25.35 | 25.4 | Molecular physiology of low-voltage-activated t-type calcium channels. | Edward Perez-Reyes | Physiol. Rev. | 2003 | 12506128 | No |
| 2161 | 979 | 979.0 | 30.22 | 30.2 | Plasmonics: merging photonics and electronics at nanoscale dimensions. | Ekmel Ozbay | Science | 2006 | 16410515 | Yes |
| 2162 | 1956 | 978.0 | 65.79 | 32.9 | Production of single-stranded plasmid DNA. | J Vieira, J Messing | Meth. Enzymol. | 1987 | 3323803 | Yes |
| 2163 | 978 | 978.0 | 42.41 | 42.4 | The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. | Poul Erik Petersen | Community Dent Oral Epidemiol | 2003 | 15015736 | Yes |
| 2164 | 978 | 978.0 | 30.02 | 30.0 | Pain and emotion interactions in subregions of the cingulate gyrus. | Brent A Vogt | Nat. Rev. Neurosci. | 2005 | 15995724 | No |
| 2165 | 978 | 978.0 | 0.0 | 0.0 | The estimation of phosphorus. | R J Allen | Biochem. J. | 1940 | 16747230 | Yes |
| 2166 | 978 | 978.0 | 32.16 | 32.2 | Plant productivity and environment. | J S Boyer | Science | 1982 | 17808529 | Yes |
| 2167 | 978 | 978.0 | 0.0 | 0.0 | CRYSTALLINE SOYBEAN TRYPSIN INHIBITOR : II. GENERAL PROPERTIES. | M Kunitz | J. Gen. Physiol. | 1947 | 19873496 | Yes |
| 2168 | 1955 | 977.5 | 79.52 | 39.8 | Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. | J E Hixson, D T Vernier | J. Lipid Res. | 1990 | 2341813 | Yes |
| 2169 | 3910 | 977.5 | 103.68 | 25.9 | SCOP: a structural classification of proteins database for the investigation of sequences and structures. | A G Murzin, S E Brenner, T Hubbard, C Chothia | J. Mol. Biol. | 1995 | 7723011 | Yes |
| 2170 | 1953 | 976.5 | 0.0 | 0.0 | Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. | J Altman, G D Das | J. Comp. Neurol. | 1965 | 5861717 | Yes |
| 2171 | 976 | 976.0 | 27.36 | 27.4 | The 'effective number of codons' used in a gene. | F Wright | Gene | 1990 | 2110097 | Yes |
| 2172 | 976 | 976.0 | 33.63 | 33.6 | The molecular genetics of cancer. | J M Bishop | Science | 1987 | 3541204 | No |
| 2173 | 3904 | 976.0 | 115.57 | 28.9 | Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. | H Nielsen, J Engelbrecht, S Brunak, G von Heijne | Protein Eng. | 1997 | 9051728 | Yes |
| 2174 | 976 | 976.0 | 28.38 | 28.4 | Primate anterior cingulate cortex: where motor control, drive and cognition interface. | T Paus | Nat. Rev. Neurosci. | 2001 | 11389475 | No |
| 2175 | 1951 | 975.5 | 0.0 | 0.0 | Assay of proteins in the presence of interfering materials. | A Bensadoun, D Weinstein | Anal. Biochem. | 1976 | 1259145 | Yes |
| 2176 | 1950 | 975.0 | 0.0 | 0.0 | Prediction of protein conformation. | P Y Chou, G D Fasman | Biochemistry | 1974 | 4358940 | Yes |
| 2177 | 975 | 975.0 | 0.0 | 0.0 | The organization of proteins in the human red blood cell membrane. A review. | T L Steck | J. Cell Biol. | 1974 | 4600883 | No |
| 2178 | 975 | 975.0 | 0.0 | 0.0 | Defective repair replication of DNA in xeroderma pigmentosum. | J E Cleaver | Nature | 1968 | 5655953 | Yes |
| 2179 | 975 | 975.0 | 83.11 | 83.1 | The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. | F Denis | Spine | 1983 | 6670016 | Yes |
| 2180 | 975 | 975.0 | 20.56 | 20.6 | A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. | Xuemei Chen | Science | 2004 | 12893888 | Yes |
| 2181 | 2924 | 974.7 | 70.3 | 23.4 | Calcium signalling: dynamics, homeostasis and remodelling. | Michael J Berridge, Martin D Bootman, H Llewelyn Roderick | Nat. Rev. Mol. Cell Biol. | 2003 | 12838335 | No |
| 2182 | 974 | 974.0 | 0.0 | 0.0 | Superoxide dismutases. | I Fridovich | Annu. Rev. Biochem. | 1975 | 1094908 | No |
| 2183 | 974 | 974.0 | 82.22 | 82.2 | Impingement lesions. | C S Neer | Clin. Orthop. Relat. Res. | 1983 | 6825348 | Yes |
| 2184 | 974 | 974.0 | 22.78 | 22.8 | Morphogenetic roles of classic cadherins. | M Takeichi | Curr. Opin. Cell Biol. | 1995 | 8573335 | No |
| 2185 | 974 | 974.0 | 26.0 | 26.0 | Production of recombinant protein therapeutics in cultivated mammalian cells. | Florian M Wurm | Nat. Biotechnol. | 2004 | 15529164 | No |
| 2186 | 974 | 974.0 | 30.35 | 30.4 | Q-ball imaging. | David S Tuch | Magn Reson Med | 2004 | 15562495 | Yes |
| 2187 | 1947 | 973.5 | 64.64 | 32.3 | Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. | E Y Chen, P H Seeburg | DNA | 1985 | 3996185 | Yes |
| 2188 | 1947 | 973.5 | 62.44 | 31.2 | Imaging cognition II: An empirical review of 275 PET and fMRI studies. | R Cabeza, L Nyberg | J Cogn Neurosci | 2000 | 10769304 | No |
| 2189 | 973 | 973.0 | 41.83 | 41.8 | Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. | K Anders Ericsson | Acad Med | 2004 | 15383395 | No |
| 2190 | 973 | 973.0 | 22.33 | 22.3 | Maintenance of C. elegans. | Theresa Stiernagle | WormBook | 2006 | 18050451 | No |
| 2191 | 973 | 973.0 | 42.33 | 42.3 | Functional and effective connectivity: a review. | Karl J Friston | Brain Connect | 2011 | 22432952 | No |
| 2192 | 972 | 972.0 | 0.0 | 0.0 | Drugs which inhibit prostaglandin biosynthesis. | R J Flower | Pharmacol. Rev. | 1974 | 4208101 | Yes |
| 2193 | 972 | 972.0 | 0.0 | 0.0 | Computerized transverse axial scanning (tomography). 1. Description of system. | G N Hounsfield | Br J Radiol | 1973 | 4757352 | Yes |
| 2194 | 972 | 972.0 | 49.77 | 49.8 | Cardiac valve surgery--the "French correction". | A Carpentier | J. Thorac. Cardiovasc. Surg. | 1983 | 6887954 | Yes |
| 2195 | 972 | 972.0 | 24.41 | 24.4 | Transcriptional control of adipocyte formation. | Stephen R Farmer | Cell Metab. | 2006 | 17011499 | No |
| 2196 | 1943 | 971.5 | 0.0 | 0.0 | Maximum utilization of the life table method in analyzing survival. | S J CUTLER, F EDERER | J Chronic Dis | 1958 | 13598782 | Yes |
| 2197 | 971 | 971.0 | 45.11 | 45.1 | Lyme disease. | A C Steere | N. Engl. J. Med. | 1989 | 2668764 | No |
| 2198 | 971 | 971.0 | 0.0 | 0.0 | Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. | J W Olney | Science | 1969 | 5778021 | Yes |
| 2199 | 1942 | 971.0 | 69.5 | 34.8 | Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. | M J Casadaban, S N Cohen | J. Mol. Biol. | 1980 | 6997493 | Yes |
| 2200 | 971 | 971.0 | 26.66 | 26.7 | Allelic discrimination using fluorogenic probes and the 5' nuclease assay. | K J Livak | Genet. Anal. | 1999 | 10084106 | Yes |
| 2201 | 971 | 971.0 | 26.46 | 26.5 | Liver fibrosis -- from bench to bedside. | Scott L Friedman | J. Hepatol. | 2003 | 12591185 | No |
| 2202 | 2913 | 971.0 | 72.36 | 24.1 | OrthoMCL: identification of ortholog groups for eukaryotic genomes. | Li Li, Christian J Stoeckert, David S Roos | Genome Res. | 2003 | 12952885 | Yes |
| 2203 | 970 | 970.0 | 22.98 | 23.0 | STATs: signal transducers and activators of transcription. | J N Ihle | Cell | 1996 | 8608586 | No |
| 2204 | 970 | 970.0 | 22.28 | 22.3 | Cytokines induce the development of functionally heterogeneous T helper cell subsets. | A O'Garra | Immunity | 1998 | 9529145 | No |
| 2205 | 970 | 970.0 | 26.2 | 26.2 | Mitochondrial transport of cations: channels, exchangers, and permeability transition. | P Bernardi | Physiol. Rev. | 1999 | 10508231 | No |
| 2206 | 970 | 970.0 | 23.52 | 23.5 | The roles of intracellular protein-degradation pathways in neurodegeneration. | David C Rubinsztein | Nature | 2006 | 17051204 | No |
| 2207 | 969 | 969.0 | 45.85 | 45.9 | The life and times of the Enterococcus. | B E Murray | Clin. Microbiol. Rev. | 1990 | 2404568 | No |
| 2208 | 969 | 969.0 | 35.72 | 35.7 | Early signals in the mitogenic response. | E Rozengurt | Science | 1986 | 3018928 | No |
| 2209 | 1937 | 968.5 | 47.91 | 24.0 | Functions of lipid rafts in biological membranes. | D A Brown, E London | Annu. Rev. Cell Dev. Biol. | 1998 | 9891780 | No |
| 2210 | 2905 | 968.3 | 67.73 | 22.6 | Cellular survival: a play in three Akts. | S R Datta, A Brunet, M E Greenberg | Genes Dev. | 1999 | 10579998 | No |
| 2211 | 968 | 968.0 | 33.89 | 33.9 | Tumor necrosis factor (TNF). | L J Old | Science | 1985 | 2413547 | Yes |
| 2212 | 1936 | 968.0 | 53.27 | 26.6 | Raster3D Version 2.0. A program for photorealistic molecular graphics. | E A Merritt, M E Murphy | Acta Crystallogr. D Biol. Crystallogr. | 1994 | 15299354 | Yes |
| 2213 | 1935 | 967.5 | 53.27 | 26.6 | Peroxisome proliferator-activated receptors: nuclear control of metabolism. | B Desvergne, W Wahli | Endocr. Rev. | 1999 | 10529898 | No |
| 2214 | 2902 | 967.3 | 133.39 | 44.5 | Vascular endothelial cells synthesize nitric oxide from L-arginine. | R M Palmer, D S Ashton, S Moncada | Nature | 1988 | 3131684 | Yes |
| 2215 | 1934 | 967.0 | 64.71 | 32.4 | Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. | M D Pierschbacher, E Ruoslahti | Nature | 1984 | 6325925 | Yes |
| 2216 | 967 | 967.0 | 44.87 | 44.9 | Linkage map of Escherichia coli K-12, edition 7. | B J Bachmann | Microbiol. Rev. | 1983 | 6348505 | No |
| 2217 | 1934 | 967.0 | 64.93 | 32.5 | A review of central 5-HT receptors and their function. | N M Barnes, T Sharp | Neuropharmacology | 1999 | 10462127 | No |
| 2218 | 967 | 967.0 | 31.22 | 31.2 | The cancer stem cell: premises, promises and challenges. | Hans Clevers | Nat. Med. | 2011 | 21386835 | No |
| 2219 | 1934 | 967.0 | 101.14 | 50.6 | Regulation of microRNA biogenesis. | Minju Ha, V Narry Kim | Nat. Rev. Mol. Cell Biol. | 2014 | 25027649 | No |
| 2220 | 966 | 966.0 | 53.09 | 53.1 | The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. | E J Khantzian | Am J Psychiatry | 1985 | 3904487 | No |
| 2221 | 966 | 966.0 | 27.34 | 27.3 | Matrix proteoglycans: from molecular design to cellular function. | R V Iozzo | Annu. Rev. Biochem. | 1998 | 9759499 | No |
| 2222 | 1932 | 966.0 | 69.15 | 34.6 | The cortical organization of speech processing. | Gregory Hickok, David Poeppel | Nat. Rev. Neurosci. | 2007 | 17431404 | No |
| 2223 | 965 | 965.0 | 0.0 | 0.0 | An enzymic method for the trace iodination of immunoglobulins and other proteins. | J J Marchalonis | Biochem. J. | 1969 | 4185494 | Yes |
| 2224 | 965 | 965.0 | 35.25 | 35.2 | Diversity of group types, regulation, and function of phospholipase A2. | E A Dennis | J. Biol. Chem. | 1994 | 8175726 | No |
| 2225 | 965 | 965.0 | 32.53 | 32.5 | Low density lipoprotein oxidation and its pathobiological significance. | D Steinberg | J. Biol. Chem. | 1997 | 9261091 | No |
| 2226 | 2895 | 965.0 | 72.15 | 24.1 | Multidrug resistance in cancer: role of ATP-dependent transporters. | Michael M Gottesman, Tito Fojo, Susan E Bates | Nat. Rev. Cancer | 2002 | 11902585 | No |
| 2227 | 965 | 965.0 | 41.13 | 41.1 | The global impact of pre-eclampsia and eclampsia. | Lelia Duley | Semin. Perinatol. | 2009 | 19464502 | No |
| 2228 | 1930 | 965.0 | 71.18 | 35.6 | Astrocytes: biology and pathology. | Michael V Sofroniew, Harry V Vinters | Acta Neuropathol. | 2010 | 20012068 | No |
| 2229 | 964 | 964.0 | 32.78 | 32.8 | Phylogenies from molecular sequences: inference and reliability. | J Felsenstein | Annu. Rev. Genet. | 1988 | 3071258 | No |
| 2230 | 964 | 964.0 | 25.84 | 25.8 | Diarylethenes for Memories and Switches. | Masahiro Irie | Chem. Rev. | 2000 | 11777416 | Yes |
| 2231 | 964 | 964.0 | 25.44 | 25.4 | Pedigree disequilibrium tests for multilocus haplotypes. | Frank Dudbridge | Genet. Epidemiol. | 2003 | 12916020 | Yes |
| 2232 | 964 | 964.0 | 28.68 | 28.7 | Overview of general physiologic features and functions of vitamin D. | Hector F DeLuca | Am. J. Clin. Nutr. | 2004 | 15585789 | No |
| 2233 | 964 | 964.0 | 37.37 | 37.4 | Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? | Thomas Grobner | Nephrol. Dial. Transplant. | 2006 | 16431890 | Yes |
| 2234 | 964 | 964.0 | 31.41 | 31.4 | Atopic dermatitis. | Thomas Bieber | N. Engl. J. Med. | 2008 | 18385500 | Yes |
| 2235 | 7711 | 963.9 | 227.11 | 28.4 | Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. | N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M Joliot | Neuroimage | 2002 | 11771995 | Yes |
| 2236 | 1927 | 963.5 | 129.79 | 64.9 | Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. | S F Dworkin, L LeResche | J Craniomandib Disord | 1992 | 1298767 | No |
| 2237 | 963 | 963.0 | 0.0 | 0.0 | Metabolic stability and epigenesis in randomly constructed genetic nets. | S A Kauffman | J. Theor. Biol. | 1969 | 5803332 | Yes |
| 2238 | 1925 | 962.5 | 0.0 | 0.0 | Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. | L F Berkman, S L Syme | Am. J. Epidemiol. | 1979 | 425958 | Yes |
| 2239 | 2887 | 962.3 | 79.24 | 26.4 | Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. | Christian W Tornøe, Caspar Christensen, Morten Meldal | J. Org. Chem. | 2002 | 11975567 | Yes |
| 2240 | 962 | 962.0 | 33.21 | 33.2 | The induction of pain: an integrative review. | M J Millan | Prog. Neurobiol. | 1999 | 9987804 | No |
| 2241 | 1924 | 962.0 | 76.27 | 38.1 | The pathogenesis of rheumatoid arthritis. | Iain B McInnes, Georg Schett | N. Engl. J. Med. | 2011 | 22150039 | No |
| 2242 | 962 | 962.0 | 43.49 | 43.5 | Asthma phenotypes: the evolution from clinical to molecular approaches. | Sally E Wenzel | Nat. Med. | 2012 | 22561835 | No |
| 2243 | 961 | 961.0 | 0.0 | 0.0 | The measurement of psychological androgyny. | S L Bem | J Consult Clin Psychol | 1974 | 4823550 | Yes |
| 2244 | 961 | 961.0 | 28.16 | 28.2 | The neuropathology of schizophrenia. A critical review of the data and their interpretation. | P J Harrison | Brain | 1999 | 10219775 | No |
| 2245 | 4804 | 960.8 | 96.37 | 19.3 | Crystal structure of the nucleosome core particle at 2.8 A resolution. | K Luger, A W Mäder, R K Richmond, D F Sargent, T J Richmond | Nature | 1997 | 9305837 | Yes |
| 2246 | 1921 | 960.5 | 0.0 | 0.0 | The effect of sodium ions on the electrical activity of giant axon of the squid. | A L HODGKIN, B KATZ | J. Physiol. (Lond.) | 1949 | 18128147 | Yes |
| 2247 | 960 | 960.0 | 30.31 | 30.3 | Psychological and neural mechanisms of the affective dimension of pain. | D D Price | Science | 2000 | 10846154 | No |
| 2248 | 2880 | 960.0 | 68.6 | 22.9 | Toll-like receptors: critical proteins linking innate and acquired immunity. | S Akira, K Takeda, T Kaisho | Nat. Immunol. | 2001 | 11477402 | No |
| 2249 | 4798 | 959.6 | 234.34 | 46.9 | Evidence based medicine: what it is and what it isn't. | D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S Richardson | BMJ | 1996 | 8555924 | No |
| 2250 | 1919 | 959.5 | 56.45 | 28.2 | Statistical tests of neutrality of mutations. | Y X Fu, W H Li | Genetics | 1993 | 8454210 | Yes |
| 2251 | 959 | 959.0 | 18.45 | 18.4 | Stem cells: units of development, units of regeneration, and units in evolution. | I L Weissman | Cell | 2000 | 10647940 | No |
| 2252 | 1918 | 959.0 | 60.03 | 30.0 | Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. | Barry J Everitt, Trevor W Robbins | Nat. Neurosci. | 2005 | 16251991 | No |
| 2253 | 2877 | 959.0 | 176.4 | 58.8 | HISAT: a fast spliced aligner with low memory requirements. | Daehwan Kim, Ben Langmead, Steven L Salzberg | Nat. Methods | 2015 | 25751142 | Yes |
| 2254 | 958 | 958.0 | 40.61 | 40.6 | SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. | B P O'Connor | Behav Res Methods Instrum Comput | 2000 | 11029811 | Yes |
| 2255 | 958 | 958.0 | 0.0 | 0.0 | ANTIGEN-ANTIBODY CROSSED ELECTROPHORESIS. | C B LAURELL | Anal. Biochem. | 1965 | 14302464 | Yes |
| 2256 | 1915 | 957.5 | 67.73 | 33.9 | Genome regulation by long noncoding RNAs. | John L Rinn, Howard Y Chang | Annu. Rev. Biochem. | 2012 | 22663078 | No |
| 2257 | 957 | 957.0 | 25.06 | 25.1 | Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. | Michael J Sanderson | Mol. Biol. Evol. | 2002 | 11752195 | Yes |
| 2258 | 957 | 957.0 | 31.51 | 31.5 | Synergy, antagonism, and what the chequerboard puts between them. | F C Odds | J. Antimicrob. Chemother. | 2003 | 12805255 | No |
| 2259 | 957 | 957.0 | 26.51 | 26.5 | Pathways of oxidative damage. | James A Imlay | Annu. Rev. Microbiol. | 2003 | 14527285 | No |
| 2260 | 957 | 957.0 | 25.75 | 25.8 | The impact of next-generation sequencing technology on genetics. | Elaine R Mardis | Trends Genet. | 2008 | 18262675 | No |
| 2261 | 957 | 957.0 | 23.53 | 23.5 | Neuroligins and neurexins link synaptic function to cognitive disease. | Thomas C Südhof | Nature | 2008 | 18923512 | No |
| 2262 | 1913 | 956.5 | 49.13 | 24.6 | A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. | N C Andrews, D V Faller | Nucleic Acids Res. | 1991 | 2041787 | Yes |
| 2263 | 956 | 956.0 | 0.0 | 0.0 | Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. | J C Unkeless | J. Exp. Med. | 1979 | 90108 | Yes |
| 2264 | 956 | 956.0 | 41.21 | 41.2 | Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. | Thomas Heberer | Toxicol. Lett. | 2002 | 11988354 | Yes |
| 2265 | 955 | 955.0 | 31.22 | 31.2 | Normalization of cell responses in cat striate cortex. | D J Heeger | Vis. Neurosci. | 1992 | 1504027 | Yes |
| 2266 | 955 | 955.0 | 88.12 | 88.1 | The problem of rigor in qualitative research. | M Sandelowski | ANS Adv Nurs Sci | 1986 | 3083765 | Yes |
| 2267 | 955 | 955.0 | 33.75 | 33.8 | Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. | S L Friedman | N. Engl. J. Med. | 1993 | 8502273 | No |
| 2268 | 955 | 955.0 | 25.87 | 25.9 | Ordered porous materials for emerging applications. | Mark E Davis | Nature | 2002 | 12075343 | No |
| 2269 | 955 | 955.0 | 20.82 | 20.8 | Protein kinases--the major drug targets of the twenty-first century? | Philip Cohen | Nat Rev Drug Discov | 2002 | 12120282 | No |
| 2270 | 955 | 955.0 | 22.89 | 22.9 | Assortative mixing in networks. | M E J Newman | Phys. Rev. Lett. | 2002 | 12443515 | Yes |
| 2271 | 955 | 955.0 | 24.88 | 24.9 | Nuclear factor-kappaB: the enemy within. | Bharat B Aggarwal | Cancer Cell | 2004 | 15380510 | No |
| 2272 | 955 | 955.0 | 23.31 | 23.3 | Solving structures of protein complexes by molecular replacement with Phaser. | Airlie J McCoy | Acta Crystallogr. D Biol. Crystallogr. | 2007 | 17164524 | Yes |
| 2273 | 1909 | 954.5 | 46.89 | 23.4 | T-cell antigen receptor genes and T-cell recognition. | M M Davis, P J Bjorkman | Nature | 1988 | 3043226 | No |
| 2274 | 954 | 954.0 | 29.65 | 29.6 | Surrogate endpoints in clinical trials: definition and operational criteria. | R L Prentice | Stat Med | 1989 | 2727467 | Yes |
| 2275 | 953 | 953.0 | 26.39 | 26.4 | Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. | T A Springer | Annu. Rev. Physiol. | 1995 | 7778885 | No |
| 2276 | 1906 | 953.0 | 42.19 | 21.1 | NF-kappaB at the crossroads of life and death. | Michael Karin, Anning Lin | Nat. Immunol. | 2002 | 11875461 | No |
| 2277 | 953 | 953.0 | 21.48 | 21.5 | Mechanisms of caspase activation and inhibition during apoptosis. | Yigong Shi | Mol. Cell | 2002 | 11931755 | No |
| 2278 | 953 | 953.0 | 49.57 | 49.6 | MorphoJ: an integrated software package for geometric morphometrics. | Christian Peter Klingenberg | Mol Ecol Resour | 2011 | 21429143 | Yes |
| 2279 | 1905 | 952.5 | 74.73 | 37.4 | Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. | J I Morgan, T Curran | Annu. Rev. Neurosci. | 1991 | 1903243 | No |
| 2280 | 1905 | 952.5 | 0.0 | 0.0 | A new scale of social desirability independent of psychopathology. | D P CROWNE, D MARLOWE | J Consult Psychol | 1960 | 13813058 | Yes |
| 2281 | 2857 | 952.3 | 101.21 | 33.7 | Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. | H King, R E Aubert, W H Herman | Diabetes Care | 1998 | 9727886 | Yes |
| 2282 | 1904 | 952.0 | 63.72 | 31.9 | Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. | R G Phillips, J E LeDoux | Behav. Neurosci. | 1992 | 1590953 | Yes |
| 2283 | 952 | 952.0 | 47.18 | 47.2 | Multiple calcium channels and neuronal function. | R J Miller | Science | 1987 | 2432656 | No |
| 2284 | 952 | 952.0 | 36.2 | 36.2 | The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. | A S Fauci | Science | 1988 | 3277274 | No |
| 2285 | 952 | 952.0 | 47.79 | 47.8 | Biology of interleukin 1. | C A Dinarello | FASEB J. | 1988 | 3277884 | No |
| 2286 | 952 | 952.0 | 23.32 | 23.3 | Stem cells in the central nervous system. | R McKay | Science | 1997 | 9082987 | No |
| 2287 | 1904 | 952.0 | 46.16 | 23.1 | Toll-like receptors in the induction of the innate immune response. | A Aderem, R J Ulevitch | Nature | 2000 | 10963608 | No |
| 2288 | 952 | 952.0 | 0.0 | 0.0 | Fluorescent antibody methods. | A H COONS | Gen Cytochem Methods | 1958 | 13574437 | Yes |
| 2289 | 1904 | 952.0 | 57.71 | 28.9 | Therapeutic potential of resveratrol: the in vivo evidence. | Joseph A Baur, David A Sinclair | Nat Rev Drug Discov | 2006 | 16732220 | No |
| 2290 | 3807 | 951.8 | 102.09 | 25.5 | A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. | Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry Sharpless | Angew. Chem. Int. Ed. Engl. | 2002 | 12203546 | Yes |
| 2291 | 1903 | 951.5 | 80.47 | 40.2 | The framing of decisions and the psychology of choice. | A Tversky, D Kahneman | Science | 1981 | 7455683 | Yes |
| 2292 | 1903 | 951.5 | 61.16 | 30.6 | Meeting of minds: the medial frontal cortex and social cognition. | David M Amodio, Chris D Frith | Nat. Rev. Neurosci. | 2006 | 16552413 | No |
| 2293 | 1902 | 951.0 | 126.72 | 63.4 | A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. | M Roland, R Morris | Spine | 1983 | 6222486 | Yes |
| 2294 | 951 | 951.0 | 43.95 | 44.0 | Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. | T Florian Jaeger | J Mem Lang | 2008 | 19884961 | Yes |
| 2295 | 951 | 951.0 | 53.91 | 53.9 | Exploring Structure-Activity Data Using the Landscape Paradigm. | Rajarshi Guha | Wiley Interdiscip Rev Comput Mol Sci | 2012 | 24163705 | Yes |
| 2296 | 1901 | 950.5 | 37.53 | 18.8 | Hedgehog signaling in animal development: paradigms and principles. | P W Ingham, A P McMahon | Genes Dev. | 2001 | 11731473 | No |
| 2297 | 950 | 950.0 | 30.88 | 30.9 | Internal models for motor control and trajectory planning. | M Kawato | Curr. Opin. Neurobiol. | 1999 | 10607637 | No |
| 2298 | 1899 | 949.5 | 85.39 | 42.7 | Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. | Sarvajeet Singh Gill, Narendra Tuteja | Plant Physiol. Biochem. | 2010 | 20870416 | No |
| 2299 | 949 | 949.0 | 25.52 | 25.5 | The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. | G B Morin | Cell | 1989 | 2805070 | Yes |
| 2300 | 949 | 949.0 | 31.17 | 31.2 | Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. | C Taswell | J. Immunol. | 1981 | 7009746 | Yes |
| 2301 | 949 | 949.0 | 23.71 | 23.7 | Version 1.2 of the Crystallography and NMR system. | Axel T Brunger | Nat Protoc | 2007 | 18007608 | Yes |
| 2302 | 1897 | 948.5 | 54.83 | 27.4 | Regulation mechanisms and signaling pathways of autophagy. | Congcong He, Daniel J Klionsky | Annu. Rev. Genet. | 2009 | 19653858 | No |
| 2303 | 1897 | 948.5 | 57.57 | 28.8 | Cell signaling by receptor tyrosine kinases. | Mark A Lemmon, Joseph Schlessinger | Cell | 2010 | 20602996 | No |
| 2304 | 948 | 948.0 | 0.0 | 0.0 | Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. | T Spector | Anal. Biochem. | 1978 | 655375 | Yes |
| 2305 | 948 | 948.0 | 42.04 | 42.0 | The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. | A Raine | Schizophr Bull | 1991 | 1805349 | Yes |
| 2306 | 948 | 948.0 | 24.18 | 24.2 | The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. | S E Kahn | Diabetologia | 2003 | 12637977 | No |
| 2307 | 1895 | 947.5 | 63.75 | 31.9 | Increasing incidence of thyroid cancer in the United States, 1973-2002. | Louise Davies, H Gilbert Welch | JAMA | 2006 | 16684987 | Yes |
| 2308 | 947 | 947.0 | 0.0 | 0.0 | Optimal foraging, the marginal value theorem. | E L Charnov | Theor Popul Biol | 1976 | 1273796 | Yes |
| 2309 | 947 | 947.0 | 50.11 | 50.1 | A cochlear frequency-position function for several species--29 years later. | D D Greenwood | J. Acoust. Soc. Am. | 1990 | 2373794 | Yes |
| 2310 | 947 | 947.0 | 29.73 | 29.7 | Understanding biofilm resistance to antibacterial agents. | David Davies | Nat Rev Drug Discov | 2003 | 12563302 | No |
| 2311 | 1893 | 946.5 | 76.88 | 38.4 | Oxidative mechanisms in the toxicity of metal ions. | S J Stohs, D Bagchi | Free Radic. Biol. Med. | 1995 | 7744317 | No |
| 2312 | 946 | 946.0 | 63.52 | 63.5 | The determinants of parenting: a process model. | J Belsky | Child Dev | 1984 | 6705636 | Yes |
| 2313 | 946 | 946.0 | 30.06 | 30.1 | Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. | Earl S Ford | Diabetes Care | 2005 | 15983333 | No |
| 2314 | 2838 | 946.0 | 65.97 | 22.0 | Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). | Michael J Rust, Mark Bates, Xiaowei Zhuang | Nat. Methods | 2006 | 16896339 | Yes |
| 2315 | 946 | 946.0 | 0.0 | 0.0 | Note on the sampling error of the difference between correlated proportions or percentages. | Q McNEMAR | Psychometrika | 1947 | 20254758 | Yes |
| 2316 | 945 | 945.0 | 23.25 | 23.2 | The finer things in X-ray diffraction data collection. | J W Pflugrath | Acta Crystallogr. D Biol. Crystallogr. | 1999 | 10531521 | Yes |
| 2317 | 945 | 945.0 | 0.0 | 0.0 | A personality scale of manifest anxiety. | J A TAYLOR | J Abnorm Psychol | 1953 | 13052352 | Yes |
| 2318 | 1890 | 945.0 | 122.38 | 61.2 | A new initiative on precision medicine. | Francis S Collins, Harold Varmus | N. Engl. J. Med. | 2015 | 25635347 | Yes |
| 2319 | 944 | 944.0 | 24.91 | 24.9 | Next-generation DNA sequencing methods. | Elaine R Mardis | Annu Rev Genomics Hum Genet | 2008 | 18576944 | No |
| 2320 | 1887 | 943.5 | 0.0 | 0.0 | Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. | G Blobel, B Dobberstein | J. Cell Biol. | 1975 | 811671 | Yes |
| 2321 | 943 | 943.0 | 33.33 | 33.3 | Analyzing the mosaic structure of genes. | J M Smith | J. Mol. Evol. | 1992 | 1556748 | No |
| 2322 | 1886 | 943.0 | 55.53 | 27.8 | Microglia: active sensor and versatile effector cells in the normal and pathologic brain. | Uwe-Karsten Hanisch, Helmut Kettenmann | Nat. Neurosci. | 2007 | 17965659 | No |
| 2323 | 1885 | 942.5 | 45.68 | 22.8 | Sequence logos: a new way to display consensus sequences. | T D Schneider, R M Stephens | Nucleic Acids Res. | 1990 | 2172928 | Yes |
| 2324 | 942 | 942.0 | 22.38 | 22.4 | Chromosomal translocations in human cancer. | T H Rabbitts | Nature | 1994 | 7969446 | No |
| 2325 | 942 | 942.0 | 24.29 | 24.3 | Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis. | Tirion | Phys. Rev. Lett. | 1996 | 10063201 | Yes |
| 2326 | 942 | 942.0 | 46.7 | 46.7 | Translating social ecological theory into guidelines for community health promotion. | D Stokols | Am J Health Promot | 1996 | 10159709 | No |
| 2327 | 942 | 942.0 | 24.71 | 24.7 | DNA damage, aging, and cancer. | Jan H J Hoeijmakers | N. Engl. J. Med. | 2009 | 19812404 | No |
| 2328 | 941 | 941.0 | 34.32 | 34.3 | A Wilcoxon-type test for trend. | J Cuzick | Stat Med | 1985 | 3992076 | Yes |
| 2329 | 1881 | 940.5 | 0.0 | 0.0 | Glutathione peroxidase activity in selenium-deficient rat liver. | R A Lawrence, R F Burk | Biochem. Biophys. Res. Commun. | 1976 | 971321 | Yes |
| 2330 | 1881 | 940.5 | 0.0 | 0.0 | Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. | R L Heath, L Packer | Arch. Biochem. Biophys. | 1968 | 5655425 | Yes |
| 2331 | 940 | 940.0 | 20.18 | 20.2 | Regulation of phosphoinositide-specific phospholipase C. | S G Rhee | Annu. Rev. Biochem. | 2001 | 11395409 | No |
| 2332 | 940 | 940.0 | 24.12 | 24.1 | Neurobiology of Pavlovian fear conditioning. | S Maren | Annu. Rev. Neurosci. | 2001 | 11520922 | No |
| 2333 | 1880 | 940.0 | 59.02 | 29.5 | Nanostructures in biodiagnostics. | Nathaniel L Rosi, Chad A Mirkin | Chem. Rev. | 2005 | 15826019 | No |
| 2334 | 1880 | 940.0 | 54.7 | 27.4 | Microenvironmental regulation of metastasis. | Johanna A Joyce, Jeffrey W Pollard | Nat. Rev. Cancer | 2009 | 19279573 | No |
| 2335 | 1879 | 939.5 | 72.54 | 36.3 | Porosity of 3D biomaterial scaffolds and osteogenesis. | Vassilis Karageorgiou, David Kaplan | Biomaterials | 2005 | 15860204 | No |
| 2336 | 939 | 939.0 | 27.98 | 28.0 | Molecular themes in oncogenesis. | J M Bishop | Cell | 1991 | 1988146 | No |
| 2337 | 5634 | 939.0 | 164.33 | 27.4 | Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. | Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat Robles | Bioinformatics | 2005 | 16081474 | Yes |
| 2338 | 939 | 939.0 | 23.84 | 23.8 | Recognition and processing of ubiquitin-protein conjugates by the proteasome. | Daniel Finley | Annu. Rev. Biochem. | 2009 | 19489727 | No |
| 2339 | 1877 | 938.5 | 58.14 | 29.1 | Genetic dissection of complex traits. | E S Lander, N J Schork | Science | 1994 | 8091226 | No |
| 2340 | 1877 | 938.5 | 40.55 | 20.3 | Rho GTPases: biochemistry and biology. | Aron B Jaffe, Alan Hall | Annu. Rev. Cell Dev. Biol. | 2005 | 16212495 | No |
| 2341 | 1876 | 938.0 | 51.67 | 25.8 | The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. | P M Sharp, W H Li | Nucleic Acids Res. | 1987 | 3547335 | Yes |
| 2342 | 938 | 938.0 | 24.77 | 24.8 | Heterotrimeric G proteins: organizers of transmembrane signals. | E J Neer | Cell | 1995 | 7834744 | No |
| 2343 | 938 | 938.0 | 16.9 | 16.9 | Mitotic kinases as regulators of cell division and its checkpoints. | E A Nigg | Nat. Rev. Mol. Cell Biol. | 2001 | 11413462 | No |
| 2344 | 2813 | 937.7 | 128.76 | 42.9 | Structure-antioxidant activity relationships of flavonoids and phenolic acids. | C A Rice-Evans, N J Miller, G Paganga | Free Radic. Biol. Med. | 1996 | 8743980 | Yes |
| 2345 | 2812 | 937.3 | 80.72 | 26.9 | Functional diversity of helper T lymphocytes. | A K Abbas, K M Murphy, A Sher | Nature | 1996 | 8893001 | No |
| 2346 | 937 | 937.0 | 21.89 | 21.9 | Regulation of transcription by MAP kinase cascades. | R Treisman | Curr. Opin. Cell Biol. | 1996 | 8791420 | No |
| 2347 | 2811 | 937.0 | 64.51 | 21.5 | Large-scale analysis of the yeast proteome by multidimensional protein identification technology. | M P Washburn, D Wolters, J R Yates | Nat. Biotechnol. | 2001 | 11231557 | Yes |
| 2348 | 937 | 937.0 | 35.49 | 35.5 | Endometriosis. | Serdar E Bulun | N. Engl. J. Med. | 2009 | 19144942 | No |
| 2349 | 1873 | 936.5 | 0.0 | 0.0 | Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. | G J TODARO, H GREEN | J. Cell Biol. | 1963 | 13985244 | Yes |
| 2350 | 936 | 936.0 | 56.49 | 56.5 | What's in a name? Qualitative description revisited. | Margarete Sandelowski | Res Nurs Health | 2010 | 20014004 | Yes |
| 2351 | 1872 | 936.0 | 74.68 | 37.3 | Plasmonics for improved photovoltaic devices. | Harry A Atwater, Albert Polman | Nat Mater | 2010 | 20168344 | Yes |
| 2352 | 1871 | 935.5 | 42.29 | 21.1 | Plant pathogens and integrated defence responses to infection. | J L Dangl, J D Jones | Nature | 2001 | 11459065 | No |
| 2353 | 2806 | 935.3 | 106.58 | 35.5 | Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. | S van der Linden, H A Valkenburg, A Cats | Arthritis Rheum. | 1984 | 6231933 | Yes |
| 2354 | 2806 | 935.3 | 77.05 | 25.7 | Tissue cells feel and respond to the stiffness of their substrate. | Dennis E Discher, Paul Janmey, Yu-Li Wang | Science | 2005 | 16293750 | No |
| 2355 | 935 | 935.0 | 22.84 | 22.8 | Antigen-specific interaction between T and B cells. | A Lanzavecchia | Nature | 1985 | 3157869 | Yes |
| 2356 | 935 | 935.0 | 47.11 | 47.1 | An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. | J Kabat-Zinn | Gen Hosp Psychiatry | 1982 | 7042457 | Yes |
| 2357 | 1870 | 935.0 | 62.48 | 31.2 | Epidemiology and outcomes of osteoporotic fractures. | Steven R Cummings, L Joseph Melton | Lancet | 2002 | 12049882 | No |
| 2358 | 1870 | 935.0 | 47.97 | 24.0 | Can the pharmaceutical industry reduce attrition rates? | Ismail Kola, John Landis | Nat Rev Drug Discov | 2004 | 15286737 | No |
| 2359 | 1870 | 935.0 | 46.86 | 23.4 | Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. | Eugenia E Calle, Rudolf Kaaks | Nat. Rev. Cancer | 2004 | 15286738 | No |
| 2360 | 2804 | 934.7 | 102.53 | 34.2 | The functional anatomy of basal ganglia disorders. | R L Albin, A B Young, J B Penney | Trends Neurosci. | 1989 | 2479133 | No |
| 2361 | 1869 | 934.5 | 44.34 | 22.2 | The mammalian unfolded protein response. | Martin Schröder, Randal J Kaufman | Annu. Rev. Biochem. | 2005 | 15952902 | No |
| 2362 | 934 | 934.0 | 0.0 | 0.0 | Dopamine (3-hydroxytyramine) and brain function. | O Hornykiewicz | Pharmacol. Rev. | 1966 | 5328389 | No |
| 2363 | 934 | 934.0 | 36.45 | 36.5 | The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. | J L Cummings | Neurology | 1997 | 9153155 | No |
| 2364 | 934 | 934.0 | 23.8 | 23.8 | Topoisomerase I inhibitors: camptothecins and beyond. | Yves Pommier | Nat. Rev. Cancer | 2006 | 16990856 | No |
| 2365 | 1867 | 933.5 | 96.98 | 48.5 | Reading senseless sentences: brain potentials reflect semantic incongruity. | M Kutas, S A Hillyard | Science | 1980 | 7350657 | Yes |
| 2366 | 933 | 933.0 | 54.29 | 54.3 | Free-radical mechanisms in tissue injury. | T F Slater | Biochem. J. | 1984 | 6383353 | No |
| 2367 | 1866 | 933.0 | 0.0 | 0.0 | Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. | H J BLOOM, W W RICHARDSON | Br. J. Cancer | 1957 | 13499785 | Yes |
| 2368 | 933 | 933.0 | 35.09 | 35.1 | Recent developments in isocyanide based multicomponent reactions in applied chemistry. | Alexander Dömling | Chem. Rev. | 2006 | 16402771 | No |
| 2369 | 1864 | 932.0 | 44.91 | 22.5 | Atherosclerosis. the road ahead. | C K Glass, J L Witztum | Cell | 2001 | 11239408 | No |
| 2370 | 932 | 932.0 | 18.47 | 18.5 | The development of neural stem cells. | S Temple | Nature | 2001 | 11689956 | No |
| 2371 | 1864 | 932.0 | 36.68 | 18.3 | Stats: transcriptional control and biological impact. | David E Levy, J E Darnell | Nat. Rev. Mol. Cell Biol. | 2002 | 12209125 | No |
| 2372 | 932 | 932.0 | 30.49 | 30.5 | Physiology and pathophysiology of purinergic neurotransmission. | Geoffrey Burnstock | Physiol. Rev. | 2007 | 17429044 | No |
| 2373 | 932 | 932.0 | 31.39 | 31.4 | The origins of the developmental origins theory. | D J P Barker | J. Intern. Med. | 2007 | 17444880 | No |
| 2374 | 1864 | 932.0 | 71.44 | 35.7 | Chronic hepatitis B: update 2009. | Anna S F Lok, Brian J McMahon | Hepatology | 2009 | 19714720 | Yes |
| 2375 | 1863 | 931.5 | 84.47 | 42.2 | Total energy intake: implications for epidemiologic analyses. | W Willett, M J Stampfer | Am. J. Epidemiol. | 1986 | 3521261 | No |
| 2376 | 1863 | 931.5 | 50.67 | 25.3 | Next-generation DNA sequencing. | Jay Shendure, Hanlee Ji | Nat. Biotechnol. | 2008 | 18846087 | Yes |
| 2377 | 2794 | 931.3 | 73.67 | 24.6 | Hepatocellular carcinoma. | Josep M Llovet, Andrew Burroughs, Jordi Bruix | Lancet | 2003 | 14667750 | No |
| 2378 | 2793 | 931.0 | 66.85 | 22.3 | Predicting coiled coils from protein sequences. | A Lupas, M Van Dyke, J Stock | Science | 1991 | 2031185 | Yes |
| 2379 | 931 | 931.0 | 0.0 | 0.0 | The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. | R G Khalifah | J. Biol. Chem. | 1971 | 4994926 | Yes |
| 2380 | 1861 | 930.5 | 48.07 | 24.0 | Toll-like receptors in innate immunity. | Kiyoshi Takeda, Shizuo Akira | Int. Immunol. | 2005 | 15585605 | No |
| 2381 | 1861 | 930.5 | 61.07 | 30.5 | The cognitive control of emotion. | Kevin N Ochsner, James J Gross | Trends Cogn. Sci. (Regul. Ed.) | 2005 | 15866151 | No |
| 2382 | 1861 | 930.5 | 59.84 | 29.9 | Molecular mechanisms of long noncoding RNAs. | Kevin C Wang, Howard Y Chang | Mol. Cell | 2011 | 21925379 | No |
| 2383 | 930 | 930.0 | 29.45 | 29.4 | The basic science of gene therapy. | R C Mulligan | Science | 1993 | 8493530 | No |
| 2384 | 930 | 930.0 | 37.45 | 37.5 | Stress and disorders of the stress system. | George P Chrousos | Nat Rev Endocrinol | 2009 | 19488073 | No |
| 2385 | 930 | 930.0 | 53.94 | 53.9 | Pro-resolving lipid mediators are leads for resolution physiology. | Charles N Serhan | Nature | 2014 | 24899309 | No |
| 2386 | 3719 | 929.8 | 137.86 | 34.5 | Place navigation impaired in rats with hippocampal lesions. | R G Morris, P Garrud, J N Rawlins, J O'Keefe | Nature | 1982 | 7088155 | Yes |
| 2387 | 929 | 929.0 | 34.09 | 34.1 | The structure of common mental disorders. | R F Krueger | Arch. Gen. Psychiatry | 1999 | 10530634 | Yes |
| 2388 | 3714 | 928.5 | 126.98 | 31.7 | Prevalence and trends in obesity among US adults, 1999-2000. | Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L Johnson | JAMA | 2002 | 12365955 | Yes |
| 2389 | 1857 | 928.5 | 44.11 | 22.1 | Tumorigenesis and the angiogenic switch. | Gabriele Bergers, Laura E Benjamin | Nat. Rev. Cancer | 2003 | 12778130 | No |
| 2390 | 2785 | 928.3 | 83.1 | 27.7 | Dystrophin: the protein product of the Duchenne muscular dystrophy locus. | E P Hoffman, R H Brown, L M Kunkel | Cell | 1987 | 3319190 | Yes |
| 2391 | 1856 | 928.0 | 75.79 | 37.9 | The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. | W R Gibb, A J Lees | J. Neurol. Neurosurg. Psychiatry | 1988 | 2841426 | No |
| 2392 | 928 | 928.0 | 19.09 | 19.1 | Antigen receptor tail clue. | M Reth | Nature | 1989 | 2927501 | Yes |
| 2393 | 928 | 928.0 | 43.42 | 43.4 | Quantitative methods in the review of epidemiologic literature. | S Greenland | Epidemiol Rev | 1987 | 3678409 | Yes |
| 2394 | 928 | 928.0 | 26.54 | 26.5 | Neurons with graded response have collective computational properties like those of two-state neurons. | J J Hopfield | Proc. Natl. Acad. Sci. U.S.A. | 1984 | 6587342 | Yes |
| 2395 | 928 | 928.0 | 36.97 | 37.0 | The aging process. | D Harman | Proc. Natl. Acad. Sci. U.S.A. | 1981 | 6947277 | Yes |
| 2396 | 928 | 928.0 | 22.25 | 22.2 | Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. | Harold F Dvorak | J. Clin. Oncol. | 2002 | 12409337 | No |
| 2397 | 928 | 928.0 | 20.05 | 20.1 | Microarray data normalization and transformation. | John Quackenbush | Nat. Genet. | 2002 | 12454644 | No |
| 2398 | 928 | 928.0 | 0.0 | 0.0 | Method for the determination of hexosamines in tissues. | N F BOAS | J. Biol. Chem. | 1953 | 13117829 | Yes |
| 2399 | 928 | 928.0 | 33.56 | 33.6 | High prevalence of vitamin D inadequacy and implications for health. | Michael F Holick | Mayo Clin. Proc. | 2006 | 16529140 | No |
| 2400 | 2783 | 927.7 | 119.68 | 39.9 | Rehospitalizations among patients in the Medicare fee-for-service program. | Stephen F Jencks, Mark V Williams, Eric A Coleman | N. Engl. J. Med. | 2009 | 19339721 | Yes |
| 2401 | 1855 | 927.5 | 44.26 | 22.1 | NF-kappaB: linking inflammation and immunity to cancer development and progression. | Michael Karin, Florian R Greten | Nat. Rev. Immunol. | 2005 | 16175180 | No |
| 2402 | 2782 | 927.3 | 94.65 | 31.6 | Nitric oxide and peroxynitrite in health and disease. | Pál Pacher, Joseph S Beckman, Lucas Liaudet | Physiol. Rev. | 2007 | 17237348 | No |
| 2403 | 1854 | 927.0 | 0.0 | 0.0 | Method for the isolation of intact islets of Langerhans from the rat pancreas. | P E Lacy, M Kostianovsky | Diabetes | 1967 | 5333500 | Yes |
| 2404 | 927 | 927.0 | 21.11 | 21.1 | Inferences, questions and possibilities in Toll-like receptor signalling. | Bruce Beutler | Nature | 2004 | 15241424 | No |
| 2405 | 2781 | 927.0 | 135.79 | 45.3 | Effect of the damping function in dispersion corrected density functional theory. | Stefan Grimme, Stephan Ehrlich, Lars Goerigk | J Comput Chem | 2011 | 21370243 | Yes |
| 2406 | 2780 | 926.7 | 75.85 | 25.3 | Long non-coding RNAs: insights into functions. | Tim R Mercer, Marcel E Dinger, John S Mattick | Nat. Rev. Genet. | 2009 | 19188922 | No |
| 2407 | 926 | 926.0 | 29.61 | 29.6 | Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. | Paul Willner | Neuropsychobiology | 2005 | 16037678 | No |
| 2408 | 1851 | 925.5 | 70.91 | 35.5 | Mediation in experimental and nonexperimental studies: new procedures and recommendations. | Patrick E Shrout, Niall Bolger | Psychol Methods | 2002 | 12530702 | Yes |
| 2409 | 925 | 925.0 | 19.7 | 19.7 | Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. | R Rothstein | Meth. Enzymol. | 1991 | 2005793 | Yes |
| 2410 | 925 | 925.0 | 33.48 | 33.5 | Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. | W Sieghart | Pharmacol. Rev. | 1995 | 7568326 | No |
| 2411 | 925 | 925.0 | 35.39 | 35.4 | Depression in late life: review and commentary. | Dan G Blazer | J. Gerontol. A Biol. Sci. Med. Sci. | 2003 | 12634292 | No |
| 2412 | 925 | 925.0 | 0.0 | 0.0 | A modified ninhydrin colorimetric analysis for amino acids. | H ROSEN | Arch. Biochem. Biophys. | 1957 | 13412116 | Yes |
| 2413 | 925 | 925.0 | 28.72 | 28.7 | Reconciling the chemistry and biology of reactive oxygen species. | Christine C Winterbourn | Nat. Chem. Biol. | 2008 | 18421291 | No |
| 2414 | 925 | 925.0 | 40.16 | 40.2 | Matching methods for causal inference: A review and a look forward. | Elizabeth A Stuart | Stat Sci | 2010 | 20871802 | Yes |
| 2415 | 1848 | 924.0 | 0.0 | 0.0 | Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. | C B Lozzio, B B Lozzio | Blood | 1975 | 163658 | Yes |
| 2416 | 924 | 924.0 | 59.48 | 59.5 | Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. | P de Leva | J Biomech | 1996 | 8872282 | Yes |
| 2417 | 924 | 924.0 | 25.36 | 25.4 | Physiological and molecular basis of thyroid hormone action. | P M Yen | Physiol. Rev. | 2001 | 11427693 | No |
| 2418 | 924 | 924.0 | 0.0 | 0.0 | Intra-sexual selection in Drosophila. | A J BATEMAN | Heredity (Edinb) | 1948 | 18103134 | Yes |
| 2419 | 924 | 924.0 | 33.7 | 33.7 | Chlorophyll fluorescence: a probe of photosynthesis in vivo. | Neil R Baker | Annu Rev Plant Biol | 2008 | 18444897 | No |
| 2420 | 1847 | 923.5 | 96.51 | 48.3 | Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. | P R Hunter, M A Gaston | J. Clin. Microbiol. | 1988 | 3069867 | Yes |
| 2421 | 1847 | 923.5 | 62.39 | 31.2 | Antibiotic resistance of bacteria in biofilms. | P S Stewart, J W Costerton | Lancet | 2001 | 11463434 | No |
| 2422 | 2769 | 923.0 | 55.53 | 18.5 | Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. | S Moreno, A Klar, P Nurse | Meth. Enzymol. | 1991 | 2005825 | Yes |
| 2423 | 923 | 923.0 | 0.0 | 0.0 | An improved procedure for serum creatine phosphokinase determination. | S B Rosalki | J. Lab. Clin. Med. | 1967 | 4381359 | Yes |
| 2424 | 923 | 923.0 | 0.0 | 0.0 | Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. | J Altman | J. Comp. Neurol. | 1969 | 5361244 | Yes |
| 2425 | 2768 | 922.7 | 106.39 | 35.5 | Estimating the mean and variance from the median, range, and the size of a sample. | Stela Pudar Hozo, Benjamin Djulbegovic, Iztok Hozo | BMC Med Res Methodol | 2005 | 15840177 | Yes |
| 2426 | 1845 | 922.5 | 75.6 | 37.8 | Intracellular pH. | A Roos, W F Boron | Physiol. Rev. | 1981 | 7012859 | No |
| 2427 | 922 | 922.0 | 43.35 | 43.4 | Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. | M A Lemp | CLAO J | 1995 | 8565190 | No |
| 2428 | 922 | 922.0 | 30.62 | 30.6 | Stress and depression. | Constance Hammen | Annu Rev Clin Psychol | 2005 | 17716090 | No |
| 2429 | 922 | 922.0 | 28.74 | 28.7 | Hydrogen sulphide and its therapeutic potential. | Csaba Szabó | Nat Rev Drug Discov | 2007 | 17948022 | No |
| 2430 | 6451 | 921.6 | 343.69 | 49.1 | Development and validation of a geriatric depression screening scale: a preliminary report. | J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O Leirer | J Psychiatr Res | 1982 | 7183759 | Yes |
| 2431 | 921 | 921.0 | 35.54 | 35.5 | Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. | M J Gasson | J. Bacteriol. | 1983 | 6403500 | Yes |
| 2432 | 921 | 921.0 | 23.05 | 23.1 | Platelets in atherothrombosis. | Zaverio M Ruggeri | Nat. Med. | 2002 | 12411949 | No |
| 2433 | 921 | 921.0 | 47.82 | 47.8 | Antibiotics in the aquatic environment--a review--part I. | Klaus Kümmerer | Chemosphere | 2009 | 19185900 | No |
| 2434 | 921 | 921.0 | 35.58 | 35.6 | Signal transduction by reactive oxygen species. | Toren Finkel | J. Cell Biol. | 2011 | 21746850 | No |
| 2435 | 1842 | 921.0 | 105.56 | 52.8 | Multiwfn: a multifunctional wavefunction analyzer. | Tian Lu, Feiwu Chen | J Comput Chem | 2012 | 22162017 | Yes |
| 2436 | 5524 | 920.7 | 194.46 | 32.4 | Cancer statistics, 2007. | Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Taylor Murray, Jiaquan Xu, Michael J Thun | CA Cancer J Clin | 2007 | 17237035 | Yes |
| 2437 | 1841 | 920.5 | 58.5 | 29.2 | Apoptosis, oncosis, and necrosis. An overview of cell death. | G Majno, I Joris | Am. J. Pathol. | 1995 | 7856735 | No |
| 2438 | 920 | 920.0 | 0.0 | 0.0 | Protein denaturation. C. Theoretical models for the mechanism of denaturation. | C Tanford | Adv. Protein Chem. | 1970 | 4912353 | No |
| 2439 | 920 | 920.0 | 23.32 | 23.3 | The Unified Medical Language System (UMLS): integrating biomedical terminology. | Olivier Bodenreider | Nucleic Acids Res. | 2004 | 14681409 | Yes |
| 2440 | 920 | 920.0 | 38.71 | 38.7 | Aging, cellular senescence, and cancer. | Judith Campisi | Annu. Rev. Physiol. | 2013 | 23140366 | No |
| 2441 | 919 | 919.0 | 48.52 | 48.5 | Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. | G A McPherson | J Pharmacol Methods | 1985 | 3840547 | Yes |
| 2442 | 1838 | 919.0 | 43.35 | 21.7 | Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. | C W Greider, E H Blackburn | Cell | 1985 | 3907856 | Yes |
| 2443 | 4595 | 919.0 | 0.0 | 0.0 | Transection of the oesophagus for bleeding oesophageal varices. | R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R Williams | Br J Surg | 1973 | 4541913 | Yes |
| 2444 | 919 | 919.0 | 33.44 | 33.4 | Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. | P S Tofts | J Magn Reson Imaging | 1997 | 9039598 | No |
| 2445 | 919 | 919.0 | 25.92 | 25.9 | Oxyradicals and DNA damage. | L J Marnett | Carcinogenesis | 2000 | 10688856 | No |
| 2446 | 2756 | 918.7 | 0.0 | 0.0 | Improved method for the determination of blood glutathione. | E BEUTLER, O DURON, B M KELLY | J. Lab. Clin. Med. | 1963 | 13967893 | Yes |
| 2447 | 2754 | 918.0 | 190.59 | 63.5 | Some statistical methods useful in circulation research. | S Wallenstein, C L Zucker, J L Fleiss | Circ. Res. | 1980 | 7379260 | Yes |
| 2448 | 918 | 918.0 | 24.7 | 24.7 | The prefrontal cortex and cognitive control. | E K Miller | Nat. Rev. Neurosci. | 2000 | 11252769 | No |
| 2449 | 918 | 918.0 | 29.67 | 29.7 | How brains beware: neural mechanisms of emotional attention. | Patrik Vuilleumier | Trends Cogn. Sci. (Regul. Ed.) | 2005 | 16289871 | Yes |
| 2450 | 918 | 918.0 | 28.82 | 28.8 | Polymer conjugates as anticancer nanomedicines. | Ruth Duncan | Nat. Rev. Cancer | 2006 | 16900224 | No |
| 2451 | 918 | 918.0 | 28.87 | 28.9 | Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. | G L Semenza | Oncogene | 2010 | 19946328 | No |
| 2452 | 1836 | 918.0 | 59.45 | 29.7 | Regulation of chromatin by histone modifications. | Andrew J Bannister, Tony Kouzarides | Cell Res. | 2011 | 21321607 | No |
| 2453 | 2754 | 918.0 | 150.58 | 50.2 | Molecular mechanisms of epithelial-mesenchymal transition. | Samy Lamouille, Jian Xu, Rik Derynck | Nat. Rev. Mol. Cell Biol. | 2014 | 24556840 | No |
| 2454 | 1835 | 917.5 | 0.0 | 0.0 | Radiological demarcation of cemented sockets in total hip replacement. | J G DeLee, J Charnley | Clin. Orthop. Relat. Res. | 1976 | 991504 | Yes |
| 2455 | 917 | 917.0 | 42.53 | 42.5 | The theoretical bases of indirect calorimetry: a review. | E Ferrannini | Metab. Clin. Exp. | 1988 | 3278194 | No |
| 2456 | 917 | 917.0 | 0.0 | 0.0 | A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. | A M Olovnikov | J. Theor. Biol. | 1973 | 4754905 | Yes |
| 2457 | 917 | 917.0 | 0.0 | 0.0 | RNA metabolism in the HeLa cell nucleus. | S Penman | J. Mol. Biol. | 1966 | 5961144 | Yes |
| 2458 | 2751 | 917.0 | 104.2 | 34.7 | MR diffusion tensor spectroscopy and imaging. | P J Basser, J Mattiello, D LeBihan | Biophys. J. | 1994 | 8130344 | Yes |
| 2459 | 917 | 917.0 | 20.73 | 20.7 | Mechanisms and consequences of activation of protein kinase B/Akt. | J Downward | Curr. Opin. Cell Biol. | 1998 | 9561851 | No |
| 2460 | 1834 | 917.0 | 45.7 | 22.9 | Defining the role of mTOR in cancer. | David A Guertin, David M Sabatini | Cancer Cell | 2007 | 17613433 | No |
| 2461 | 1834 | 917.0 | 73.01 | 36.5 | Oxidative stress and diabetic complications. | Ferdinando Giacco, Michael Brownlee | Circ. Res. | 2010 | 21030723 | No |
| 2462 | 1833 | 916.5 | 46.14 | 23.1 | Lymphocyte homing and homeostasis. | E C Butcher, L J Picker | Science | 1996 | 8600538 | No |
| 2463 | 916 | 916.0 | 29.35 | 29.4 | Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. | E M Tan | Adv. Immunol. | 1989 | 2646863 | No |
| 2464 | 916 | 916.0 | 18.46 | 18.5 | Regulatory T cells in autoimmmunity*. | E M Shevach | Annu. Rev. Immunol. | 2000 | 10837065 | No |
| 2465 | 916 | 916.0 | 20.2 | 20.2 | Regulation of cadherin-mediated adhesion in morphogenesis. | Barry M Gumbiner | Nat. Rev. Mol. Cell Biol. | 2005 | 16025097 | No |
| 2466 | 1831 | 915.5 | 60.59 | 30.3 | Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. | Robert E W Hancock, Hans-Georg Sahl | Nat. Biotechnol. | 2006 | 17160061 | No |
| 2467 | 915 | 915.0 | 32.14 | 32.1 | Papillary and follicular thyroid carcinoma. | M J Schlumberger | N. Engl. J. Med. | 1998 | 9445411 | No |
| 2468 | 915 | 915.0 | 30.81 | 30.8 | Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. | P Lips | Endocr. Rev. | 2001 | 11493580 | No |
| 2469 | 915 | 915.0 | 23.34 | 23.3 | Microglia as a source and target of cytokines. | Uwe-Karsten Hanisch | Glia | 2002 | 12379902 | No |
| 2470 | 915 | 915.0 | 0.0 | 0.0 | Sequential tests for the detection of linkage. | N E MORTON | Am. J. Hum. Genet. | 1955 | 13258560 | Yes |
| 2471 | 915 | 915.0 | 0.0 | 0.0 | Starch gel electrophoresis in a discontinous system of buffers. | M D POULIK | Nature | 1957 | 13493570 | Yes |
| 2472 | 915 | 915.0 | 24.98 | 25.0 | Evaluating medication effects outside of clinical trials: new-user designs. | Wayne A Ray | Am. J. Epidemiol. | 2003 | 14585769 | Yes |
| 2473 | 1829 | 914.5 | 40.69 | 20.3 | Genomic control for association studies. | B Devlin, K Roeder | Biometrics | 1999 | 11315092 | Yes |
| 2474 | 914 | 914.0 | 44.34 | 44.3 | Social phobia. | M R Liebowitz | Mod Probl Pharmacopsychiatry | 1987 | 2885745 | Yes |
| 2475 | 914 | 914.0 | 24.96 | 25.0 | Brain tumors. | L M DeAngelis | N. Engl. J. Med. | 2001 | 11150363 | No |
| 2476 | 3656 | 914.0 | 81.43 | 20.4 | Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. | L Alexopoulou, A C Holt, R Medzhitov, R A Flavell | Nature | 2001 | 11607032 | Yes |
| 2477 | 914 | 914.0 | 38.1 | 38.1 | Risk and maintenance factors for eating pathology: a meta-analytic review. | Eric Stice | Psychol Bull | 2002 | 12206196 | No |
| 2478 | 914 | 914.0 | 35.62 | 35.6 | A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. | Ozcan Erel | Clin. Biochem. | 2004 | 15003729 | Yes |
| 2479 | 913 | 913.0 | 51.3 | 51.3 | Substance P. | B Pernow | Pharmacol. Rev. | 1983 | 6196797 | No |
| 2480 | 1826 | 913.0 | 64.17 | 32.1 | Nitric oxide synthases: roles, tolls, and controls. | C Nathan, Q W Xie | Cell | 1994 | 7522969 | No |
| 2481 | 913 | 913.0 | 27.7 | 27.7 | Somatostatin and its receptor family. | Y C Patel | Front Neuroendocrinol | 1999 | 10433861 | No |
| 2482 | 913 | 913.0 | 29.61 | 29.6 | Neural simulation of action: a unifying mechanism for motor cognition. | M Jeannerod | Neuroimage | 2001 | 11373140 | No |
| 2483 | 2739 | 913.0 | 95.45 | 31.8 | Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. | Günter Oberdörster, Eva Oberdörster, Jan Oberdörster | Environ. Health Perspect. | 2005 | 16002369 | No |
| 2484 | 913 | 913.0 | 0.0 | 0.0 | On the Absorption of Fluids from the Connective Tissue Spaces. | E H Starling | J. Physiol. (Lond.) | 1896 | 16992325 | Yes |
| 2485 | 1826 | 913.0 | 55.16 | 27.6 | Myocardial reperfusion injury. | Derek M Yellon, Derek J Hausenloy | N. Engl. J. Med. | 2007 | 17855673 | No |
| 2486 | 913 | 913.0 | 21.67 | 21.7 | Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. | Sean B Carroll | Cell | 2008 | 18614008 | Yes |
| 2487 | 912 | 912.0 | 40.9 | 40.9 | The LMS method for constructing normalized growth standards. | T J Cole | Eur J Clin Nutr | 1990 | 2354692 | Yes |
| 2488 | 912 | 912.0 | 0.0 | 0.0 | Bee and wasp venoms. | E Habermann | Science | 1972 | 4113805 | No |
| 2489 | 912 | 912.0 | 46.85 | 46.9 | Neuropeptide Y: complete amino acid sequence of the brain peptide. | K Tatemoto | Proc. Natl. Acad. Sci. U.S.A. | 1982 | 6957876 | Yes |
| 2490 | 912 | 912.0 | 30.71 | 30.7 | Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. | J Deisenhofer | Biochemistry | 1981 | 7236608 | Yes |
| 2491 | 912 | 912.0 | 30.06 | 30.1 | Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. | M Kozak | Nucleic Acids Res. | 1981 | 7301588 | Yes |
| 2492 | 912 | 912.0 | 25.37 | 25.4 | Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. | R Balfour Sartor | Nat Clin Pract Gastroenterol Hepatol | 2006 | 16819502 | No |
| 2493 | 3648 | 912.0 | 101.22 | 25.3 | Autophagy fights disease through cellular self-digestion. | Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky | Nature | 2008 | 18305538 | No |
| 2494 | 1823 | 911.5 | 87.0 | 43.5 | Genome editing. The new frontier of genome engineering with CRISPR-Cas9. | Jennifer A Doudna, Emmanuelle Charpentier | Science | 2014 | 25430774 | No |
| 2495 | 911 | 911.0 | 31.91 | 31.9 | The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. | K Kuwajima | Proteins | 1989 | 2695928 | No |
| 2496 | 911 | 911.0 | 20.7 | 20.7 | Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. | Z Yang | Mol. Biol. Evol. | 1998 | 9580986 | Yes |
| 2497 | 911 | 911.0 | 0.0 | 0.0 | The critical incident technique. | J C FLANAGAN | Psychol Bull | 1954 | 13177800 | Yes |
| 2498 | 3641 | 910.2 | 0.0 | 0.0 | The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. | L A Sternberger, P H Hardy, J J Cuculis, H G Meyer | J. Histochem. Cytochem. | 1970 | 4192899 | Yes |
| 2499 | 910 | 910.0 | 19.57 | 19.6 | The power and the promise of DNA methylation markers. | Peter W Laird | Nat. Rev. Cancer | 2003 | 12671664 | No |
| 2500 | 910 | 910.0 | 25.6 | 25.6 | Optical microcavities. | Kerry J Vahala | Nature | 2003 | 12917698 | Yes |
| 2501 | 910 | 910.0 | 0.0 | 0.0 | THE FUNCTION OF THE VERTEBRAL VEINS AND THEIR ROLE IN THE SPREAD OF METASTASES. | O V Batson | Ann. Surg. | 1940 | 17857618 | Yes |
| 2502 | 1819 | 909.5 | 0.0 | 0.0 | Surgical risk as related to time of intervention in the repair of intracranial aneurysms. | W E Hunt, R M Hess | J. Neurosurg. | 1968 | 5635959 | Yes |
| 2503 | 909 | 909.0 | 36.52 | 36.5 | Diversity and ubiquity of K channels. | B Rudy | Neuroscience | 1988 | 2457185 | No |
| 2504 | 1818 | 909.0 | 98.23 | 49.1 | Biology of disease: free radicals and tissue injury. | B A Freeman, J D Crapo | Lab. Invest. | 1982 | 6290784 | No |
| 2505 | 909 | 909.0 | 31.9 | 31.9 | Peptide antibiotics and their role in innate immunity. | H G Boman | Annu. Rev. Immunol. | 1995 | 7612236 | No |
| 2506 | 909 | 909.0 | 21.49 | 21.5 | Apoptosis in neurodegenerative disorders. | M P Mattson | Nat. Rev. Mol. Cell Biol. | 2000 | 11253364 | No |
| 2507 | 909 | 909.0 | 37.09 | 37.1 | Socioeconomic status and obesity. | Lindsay McLaren | Epidemiol Rev | 2007 | 17478442 | No |
| 2508 | 908 | 908.0 | 0.0 | 0.0 | Regulation of noradrenaline release by presynaptic receptor systems. | K Starke | Rev. Physiol. Biochem. Pharmacol. | 1977 | 14389 | No |
| 2509 | 908 | 908.0 | 17.19 | 17.2 | Molecular mechanisms of axon guidance. | Barry J Dickson | Science | 2002 | 12471249 | No |
| 2510 | 908 | 908.0 | 24.54 | 24.5 | The path to ubiquitous and low-cost organic electronic appliances on plastic. | Stephen R Forrest | Nature | 2004 | 15118718 | Yes |
| 2511 | 907 | 907.0 | 36.21 | 36.2 | The matrix-degrading metalloproteinases. | L M Matrisian | Bioessays | 1992 | 1445287 | No |
| 2512 | 907 | 907.0 | 0.0 | 0.0 | Why people use health services. | I M Rosenstock | Milbank Mem Fund Q | 1966 | 5967464 | Yes |
| 2513 | 907 | 907.0 | 27.69 | 27.7 | Neural systems for recognizing emotion. | Ralph Adolphs | Curr. Opin. Neurobiol. | 2002 | 12015233 | No |
| 2514 | 1814 | 907.0 | 52.86 | 26.4 | C-reactive protein: a critical update. | Mark B Pepys, Gideon M Hirschfield | J. Clin. Invest. | 2003 | 12813013 | No |
| 2515 | 907 | 907.0 | 0.0 | 0.0 | Cellular resistance to infection. | G B MACKANESS | J. Exp. Med. | 1962 | 14467923 | Yes |
| 2516 | 907 | 907.0 | 35.71 | 35.7 | Delirium in older persons. | Sharon K Inouye | N. Engl. J. Med. | 2006 | 16540616 | No |
| 2517 | 907 | 907.0 | 32.26 | 32.3 | Multiple imputation of discrete and continuous data by fully conditional specification. | Stef van Buuren | Stat Methods Med Res | 2007 | 17621469 | Yes |
| 2518 | 906 | 906.0 | 30.52 | 30.5 | Emotion regulation: affective, cognitive, and social consequences. | James J Gross | Psychophysiology | 2002 | 12212647 | No |
| 2519 | 906 | 906.0 | 34.76 | 34.8 | Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. | Charles A Dinarello | Blood | 2011 | 21304099 | No |
| 2520 | 1811 | 905.5 | 82.48 | 41.2 | Thermodynamics of protein association reactions: forces contributing to stability. | P D Ross, S Subramanian | Biochemistry | 1981 | 7248271 | Yes |
| 2521 | 2716 | 905.3 | 83.08 | 27.7 | Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. | C R Woese, O Kandler, M L Wheelis | Proc. Natl. Acad. Sci. U.S.A. | 1990 | 2112744 | Yes |
| 2522 | 905 | 905.0 | 0.0 | 0.0 | Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. | D B Clewell | J. Bacteriol. | 1972 | 4336693 | Yes |
| 2523 | 1810 | 905.0 | 45.58 | 22.8 | Synaptic activity and the construction of cortical circuits. | L C Katz, C J Shatz | Science | 1996 | 8895456 | No |
| 2524 | 905 | 905.0 | 26.41 | 26.4 | Metabolism and functions of glutathione in brain. | R Dringen | Prog. Neurobiol. | 2000 | 10880854 | No |
| 2525 | 905 | 905.0 | 30.21 | 30.2 | Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. | Antoine Bechara | Nat. Neurosci. | 2005 | 16251988 | No |
| 2526 | 1809 | 904.5 | 68.07 | 34.0 | The benefits of being present: mindfulness and its role in psychological well-being. | Kirk Warren Brown, Richard M Ryan | J Pers Soc Psychol | 2003 | 12703651 | Yes |
| 2527 | 904 | 904.0 | 0.0 | 0.0 | The intraclass correlation coefficient as a measure of reliability. | J J Bartko | Psychol Rep | 1966 | 5942109 | Yes |
| 2528 | 904 | 904.0 | 58.55 | 58.5 | Optical properties of biological tissues: a review. | Steven L Jacques | Phys Med Biol | 2013 | 23666068 | No |
| 2529 | 2710 | 903.3 | 78.56 | 26.2 | Wnt/beta-catenin signaling: components, mechanisms, and diseases. | Bryan T MacDonald, Keiko Tamai, Xi He | Dev. Cell | 2009 | 19619488 | No |
| 2530 | 903 | 903.0 | 33.23 | 33.2 | Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. | P J Basser | NMR Biomed | 1995 | 8739270 | No |
| 2531 | 903 | 903.0 | 23.23 | 23.2 | Human natural killer cells. | Michael A Caligiuri | Blood | 2008 | 18650461 | No |
| 2532 | 1804 | 902.0 | 0.0 | 0.0 | Selective loss of central cholinergic neurons in Alzheimer's disease. | P Davies, A J Maloney | Lancet | 1976 | 63862 | Yes |
| 2533 | 1804 | 902.0 | 64.92 | 32.5 | Recent advances in the phencyclidine model of schizophrenia. | D C Javitt, S R Zukin | Am J Psychiatry | 1991 | 1654746 | No |
| 2534 | 902 | 902.0 | 31.42 | 31.4 | General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. | R A Houghten | Proc. Natl. Acad. Sci. U.S.A. | 1985 | 2410914 | Yes |
| 2535 | 902 | 902.0 | 39.78 | 39.8 | Volumetric modulated arc therapy: IMRT in a single gantry arc. | Karl Otto | Med Phys | 2008 | 18293586 | Yes |
| 2536 | 901 | 901.0 | 34.24 | 34.2 | Relations between the statistics of natural images and the response properties of cortical cells. | D J Field | J Opt Soc Am A | 1987 | 3430225 | Yes |
| 2537 | 1802 | 901.0 | 88.5 | 44.2 | The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. | R Näätänen, T Picton | Psychophysiology | 1987 | 3615753 | Yes |
| 2538 | 901 | 901.0 | 33.85 | 33.9 | El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. Subcommittee on Motor Neuron Diseases/Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial "Clinical limits of amyotrophic lateral sclerosis" workshop contributors. | B R Brooks | J. Neurol. Sci. | 1994 | 7807156 | Yes |
| 2539 | 901 | 901.0 | 29.56 | 29.6 | The neurobiology of stress: from serendipity to clinical relevance. | B S McEwen | Brain Res. | 2000 | 11119695 | No |
| 2540 | 901 | 901.0 | 25.97 | 26.0 | The blood-brain barrier: bottleneck in brain drug development. | William M Pardridge | NeuroRx | 2005 | 15717053 | No |
| 2541 | 5403 | 900.5 | 205.5 | 34.2 | Prevalence of overweight and obesity in the United States, 1999-2004. | Cynthia L Ogden, Margaret D Carroll, Lester R Curtin, Margaret A McDowell, Carolyn J Tabak, Katherine M Flegal | JAMA | 2006 | 16595758 | Yes |
| 2542 | 3601 | 900.2 | 118.41 | 29.6 | Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. | Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S Vasan | Stat Med | 2008 | 17569110 | Yes |
| 2543 | 900 | 900.0 | 32.42 | 32.4 | Reducing children's television viewing to prevent obesity: a randomized controlled trial. | T N Robinson | JAMA | 1999 | 10546696 | Yes |
| 2544 | 900 | 900.0 | 18.96 | 19.0 | Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. | Ricky W Johnstone | Nat Rev Drug Discov | 2002 | 12120280 | No |
| 2545 | 1800 | 900.0 | 277.65 | 138.8 | A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. | Terry K Koo, Mae Y Li | J Chiropr Med | 2016 | 27330520 | Yes |
| 2546 | 1799 | 899.5 | 58.59 | 29.3 | Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. | Ajay Kumar Gupta, Mona Gupta | Biomaterials | 2005 | 15626447 | No |
| 2547 | 899 | 899.0 | 47.18 | 47.2 | Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. | S H Safe | Crit. Rev. Toxicol. | 1994 | 8037844 | No |
| 2548 | 899 | 899.0 | 18.25 | 18.2 | Biological robustness. | Hiroaki Kitano | Nat. Rev. Genet. | 2004 | 15520792 | No |
| 2549 | 899 | 899.0 | 33.09 | 33.1 | Understanding organofluorine chemistry. An introduction to the C-F bond. | David O'Hagan | Chem Soc Rev | 2008 | 18197347 | No |
| 2550 | 1796 | 898.0 | 147.12 | 73.6 | A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. | E S Grood, W J Suntay | J Biomech Eng | 1983 | 6865355 | Yes |
| 2551 | 898 | 898.0 | 34.39 | 34.4 | The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. | R G Gerrity | Am. J. Pathol. | 1981 | 7234961 | Yes |
| 2552 | 898 | 898.0 | 30.54 | 30.5 | The biochemistry and medical significance of the flavonoids. | Bent H Havsteen | Pharmacol. Ther. | 2002 | 12453566 | No |
| 2553 | 1796 | 898.0 | 59.17 | 29.6 | Alternative activation of macrophages: mechanism and functions. | Siamon Gordon, Fernando O Martinez | Immunity | 2010 | 20510870 | No |
| 2554 | 897 | 897.0 | 24.8 | 24.8 | Metastatic bone disease: clinical features, pathophysiology and treatment strategies. | R E Coleman | Cancer Treat. Rev. | 2001 | 11417967 | No |
| 2555 | 3587 | 896.8 | 108.19 | 27.0 | Microbial ecology: human gut microbes associated with obesity. | Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I Gordon | Nature | 2006 | 17183309 | Yes |
| 2556 | 896 | 896.0 | 39.47 | 39.5 | Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. | A J Alpert | J. Chromatogr. | 1990 | 2324207 | Yes |
| 2557 | 1792 | 896.0 | 77.43 | 38.7 | Unidentified curved bacilli on gastric epithelium in active chronic gastritis. | J R Warren, B Marshall | Lancet | 1983 | 6134060 | Yes |
| 2558 | 1792 | 896.0 | 0.0 | 0.0 | Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. | H A EDMONDSON, P E STEINER | Cancer | 1954 | 13160935 | Yes |
| 2559 | 1792 | 896.0 | 39.21 | 19.6 | A general framework for weighted gene co-expression network analysis. | Bin Zhang, Steve Horvath | Stat Appl Genet Mol Biol | 2005 | 16646834 | Yes |
| 2560 | 1792 | 896.0 | 47.04 | 23.5 | Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. | Jing Yang, Robert A Weinberg | Dev. Cell | 2008 | 18539112 | No |
| 2561 | 895 | 895.0 | 33.93 | 33.9 | Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. | J J Gross | J Pers Soc Psychol | 1998 | 9457784 | Yes |
| 2562 | 895 | 895.0 | 21.56 | 21.6 | Phenotypic plasticity and the epigenetics of human disease. | Andrew P Feinberg | Nature | 2007 | 17522677 | No |
| 2563 | 895 | 895.0 | 40.39 | 40.4 | Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. | Peter C Austin | Pharm Stat | 2011 | 20925139 | Yes |
| 2564 | 2684 | 894.7 | 90.41 | 30.1 | Molecular characterization of a peripheral receptor for cannabinoids. | S Munro, K L Thomas, M Abu-Shaar | Nature | 1993 | 7689702 | Yes |
| 2565 | 1789 | 894.5 | 55.11 | 27.6 | Chlorophyll fluorescence--a practical guide. | K Maxwell, G N Johnson | J. Exp. Bot. | 2000 | 10938857 | No |
| 2566 | 1789 | 894.5 | 46.43 | 23.2 | Escaping free-energy minima. | Alessandro Laio, Michele Parrinello | Proc. Natl. Acad. Sci. U.S.A. | 2002 | 12271136 | Yes |
| 2567 | 2683 | 894.3 | 78.48 | 26.2 | LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. | A C Wallace, R A Laskowski, J M Thornton | Protein Eng. | 1995 | 7630882 | Yes |
| 2568 | 894 | 894.0 | 0.0 | 0.0 | Simple methods for "staining with lead" at high pH in electron microscopy. | M J KARNOVSKY | J Biophys Biochem Cytol | 1961 | 14454024 | Yes |
| 2569 | 894 | 894.0 | 24.58 | 24.6 | Huntington's disease. | Francis O Walker | Lancet | 2007 | 17240289 | No |
| 2570 | 1787 | 893.5 | 90.6 | 45.3 | A simple method to assess exercise behavior in the community. | G Godin, R J Shephard | Can J Appl Sport Sci | 1985 | 4053261 | Yes |
| 2571 | 2680 | 893.3 | 104.1 | 34.7 | Oxidants, antioxidants, and the degenerative diseases of aging. | B N Ames, M K Shigenaga, T M Hagen | Proc. Natl. Acad. Sci. U.S.A. | 1993 | 8367443 | No |
| 2572 | 893 | 893.0 | 19.51 | 19.5 | Focal adhesion kinase: the first ten years. | J Thomas Parsons | J. Cell. Sci. | 2003 | 12640026 | No |
| 2573 | 893 | 893.0 | 20.87 | 20.9 | Protein tyrosine phosphatases: from genes, to function, to disease. | Nicholas K Tonks | Nat. Rev. Mol. Cell Biol. | 2006 | 17057753 | No |
| 2574 | 893 | 893.0 | 34.07 | 34.1 | The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. | Artemis P Simopoulos | Exp. Biol. Med. (Maywood) | 2008 | 18408140 | No |
| 2575 | 1784 | 892.0 | 42.13 | 21.1 | Checkpoints: controls that ensure the order of cell cycle events. | L H Hartwell, T A Weinert | Science | 1989 | 2683079 | No |
| 2576 | 892 | 892.0 | 29.55 | 29.6 | Pathogenesis of dengue: challenges to molecular biology. | S B Halstead | Science | 1988 | 3277268 | No |
| 2577 | 892 | 892.0 | 52.38 | 52.4 | Biomaterial-centered infection: microbial adhesion versus tissue integration. | A G Gristina | Science | 1987 | 3629258 | Yes |
| 2578 | 892 | 892.0 | 21.05 | 21.1 | Microsatellites: simple sequences with complex evolution. | Hans Ellegren | Nat. Rev. Genet. | 2004 | 15153996 | No |
| 2579 | 1784 | 892.0 | 87.02 | 43.5 | The integrative review: updated methodology. | Robin Whittemore, Kathleen Knafl | J Adv Nurs | 2005 | 16268861 | Yes |
| 2580 | 5349 | 891.5 | 145.31 | 24.2 | Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. | Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O Lötvall | Nat. Cell Biol. | 2007 | 17486113 | Yes |
| 2581 | 1783 | 891.5 | 54.16 | 27.1 | Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. | Gerard Talavera, Jose Castresana | Syst. Biol. | 2007 | 17654362 | Yes |
| 2582 | 12480 | 891.4 | 310.04 | 22.1 | Crystallography & NMR system: A new software suite for macromolecular structure determination. | A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L Warren | Acta Crystallogr. D Biol. Crystallogr. | 1998 | 9757107 | Yes |
| 2583 | 891 | 891.0 | 0.0 | 0.0 | Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. | J H Luft | Anat. Rec. | 1971 | 4108333 | Yes |
| 2584 | 1782 | 891.0 | 55.0 | 27.5 | Oxidative stress, caloric restriction, and aging. | R S Sohal, R Weindruch | Science | 1996 | 8658196 | No |
| 2585 | 891 | 891.0 | 20.77 | 20.8 | Basement membranes: structure, assembly and role in tumour angiogenesis. | Raghu Kalluri | Nat. Rev. Cancer | 2003 | 12778132 | No |
| 2586 | 891 | 891.0 | 23.35 | 23.4 | Personal genomes: The case of the missing heritability. | Brendan Maher | Nature | 2008 | 18987709 | No |
| 2587 | 1781 | 890.5 | 0.0 | 0.0 | A protein sequenator. | P Edman, G Begg | Eur. J. Biochem. | 1967 | 6059350 | Yes |
| 2588 | 1780 | 890.0 | 0.0 | 0.0 | Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. | J M Tanner, R H Whitehouse | Arch. Dis. Child. | 1976 | 952550 | Yes |
| 2589 | 890 | 890.0 | 68.2 | 68.2 | Calcium phosphate ceramics as hard tissue prosthetics. | M Jarcho | Clin. Orthop. Relat. Res. | 1981 | 7018783 | No |
| 2590 | 890 | 890.0 | 21.77 | 21.8 | Physiological concentrations of purines and pyrimidines. | T W Traut | Mol. Cell. Biochem. | 1994 | 7877593 | No |
| 2591 | 890 | 890.0 | 27.96 | 28.0 | The lipocalin protein family: structure and function. | D R Flower | Biochem. J. | 1996 | 8761444 | No |
| 2592 | 1780 | 890.0 | 49.73 | 24.9 | Hepatitis C virus infection. | G M Lauer, B D Walker | N. Engl. J. Med. | 2001 | 11439948 | No |
| 2593 | 890 | 890.0 | 22.79 | 22.8 | The myofibroblast in wound healing and fibrocontractive diseases. | G Gabbiani | J. Pathol. | 2003 | 12845617 | No |
| 2594 | 1780 | 890.0 | 44.93 | 22.5 | The canonical Notch signaling pathway: unfolding the activation mechanism. | Raphael Kopan, Maria Xenia G Ilagan | Cell | 2009 | 19379690 | No |
| 2595 | 3560 | 890.0 | 183.9 | 46.0 | Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. | David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G Altman | Int J Surg | 2010 | 20171303 | No |
| 2596 | 3558 | 889.5 | 135.11 | 33.8 | Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. | N Weidner, J P Semple, W R Welch, J Folkman | N. Engl. J. Med. | 1991 | 1701519 | Yes |
| 2597 | 1779 | 889.5 | 66.16 | 33.1 | Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. | J L Weber, P E May | Am. J. Hum. Genet. | 1989 | 2916582 | Yes |
| 2598 | 1779 | 889.5 | 57.25 | 28.6 | A neurotrophic model for stress-related mood disorders. | Ronald S Duman, Lisa M Monteggia | Biol. Psychiatry | 2006 | 16631126 | No |
| 2599 | 2668 | 889.3 | 110.41 | 36.8 | Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. | Aleksandr V Marenich, Christopher J Cramer, Donald G Truhlar | J Phys Chem B | 2009 | 19366259 | Yes |
| 2600 | 889 | 889.0 | 0.0 | 0.0 | Mutation selection and the natural history of cancer. | J Cairns | Nature | 1975 | 1143315 | Yes |
| 2601 | 889 | 889.0 | 0.0 | 0.0 | Cell lines derived from late embryonic stages of Drosophila melanogaster. | I Schneider | J Embryol Exp Morphol | 1972 | 4625067 | Yes |
| 2602 | 889 | 889.0 | 16.62 | 16.6 | Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. | M S Wold | Annu. Rev. Biochem. | 1997 | 9242902 | No |
| 2603 | 3556 | 889.0 | 106.72 | 26.7 | C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. | P M Ridker, C H Hennekens, J E Buring, N Rifai | N. Engl. J. Med. | 2000 | 10733371 | Yes |
| 2604 | 888 | 888.0 | 49.24 | 49.2 | Human agency in social cognitive theory. | A Bandura | Am Psychol | 1989 | 2782727 | Yes |
| 2605 | 888 | 888.0 | 34.8 | 34.8 | Effect of anoxia on ion distribution in the brain. | A J Hansen | Physiol. Rev. | 1985 | 3880896 | No |
| 2606 | 888 | 888.0 | 23.34 | 23.3 | ALSCRIPT: a tool to format multiple sequence alignments. | G J Barton | Protein Eng. | 1993 | 8433969 | Yes |
| 2607 | 888 | 888.0 | 25.89 | 25.9 | P-450 metabolites of arachidonic acid in the control of cardiovascular function. | Richard J Roman | Physiol. Rev. | 2002 | 11773611 | No |
| 2608 | 1775 | 887.5 | 66.3 | 33.1 | Natural products as sources of new drugs over the last 25 years. | David J Newman, Gordon M Cragg | J. Nat. Prod. | 2007 | 17309302 | No |
| 2609 | 887 | 887.0 | 0.0 | 0.0 | Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. | P Rakic | J. Comp. Neurol. | 1971 | 4101340 | Yes |
| 2610 | 1774 | 887.0 | 49.96 | 25.0 | Prediction of protein secondary structure at better than 70% accuracy. | B Rost, C Sander | J. Mol. Biol. | 1993 | 8345525 | Yes |
| 2611 | 887 | 887.0 | 27.2 | 27.2 | Drug delivery and targeting. | R Langer | Nature | 1998 | 9579855 | No |
| 2612 | 887 | 887.0 | 29.84 | 29.8 | Leishmaniasis. | B L Herwaldt | Lancet | 1999 | 10513726 | No |
| 2613 | 1773 | 886.5 | 0.0 | 0.0 | A rapid, sensitive, and specific method for the determination of protein in dilute solution. | W Schaffner, C Weissmann | Anal. Biochem. | 1973 | 4128882 | Yes |
| 2614 | 886 | 886.0 | 25.76 | 25.8 | Non-Smad pathways in TGF-beta signaling. | Ying E Zhang | Cell Res. | 2009 | 19114990 | No |
| 2615 | 1771 | 885.5 | 42.59 | 21.3 | The Hsp70 and Hsp60 chaperone machines. | B Bukau, A L Horwich | Cell | 1998 | 9476895 | No |
| 2616 | 885 | 885.0 | 55.09 | 55.1 | A cognitive approach to panic. | D M Clark | Behav Res Ther | 1986 | 3741311 | Yes |
| 2617 | 885 | 885.0 | 0.0 | 0.0 | A comparison of canal preparations in straight and curved root canals. | S W Schneider | Oral Surg. Oral Med. Oral Pathol. | 1971 | 5284110 | Yes |
| 2618 | 1770 | 885.0 | 50.71 | 25.4 | Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. | Josep M Llovet, Jordi Bruix | Hepatology | 2003 | 12540794 | No |
| 2619 | 885 | 885.0 | 20.68 | 20.7 | Liver regeneration: from myth to mechanism. | Rebecca Taub | Nat. Rev. Mol. Cell Biol. | 2004 | 15459664 | No |
| 2620 | 885 | 885.0 | 24.43 | 24.4 | Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. | Hiroshi Takayanagi | Nat. Rev. Immunol. | 2007 | 17380158 | No |
| 2621 | 1770 | 885.0 | 101.88 | 50.9 | Deciphering key features in protein structures with the new ENDscript server. | Xavier Robert, Patrice Gouet | Nucleic Acids Res. | 2014 | 24753421 | Yes |
| 2622 | 1769 | 884.5 | 69.29 | 34.6 | Population growth makes waves in the distribution of pairwise genetic differences. | A R Rogers, H Harpending | Mol. Biol. Evol. | 1992 | 1316531 | Yes |
| 2623 | 3537 | 884.2 | 105.0 | 26.2 | MEGA2: molecular evolutionary genetics analysis software. | S Kumar, K Tamura, I B Jakobsen, M Nei | Bioinformatics | 2001 | 11751241 | Yes |
| 2624 | 1768 | 884.0 | 88.84 | 44.4 | Malondialdehyde determination as index of lipid peroxidation. | H H Draper, M Hadley | Meth. Enzymol. | 1990 | 2233309 | Yes |
| 2625 | 884 | 884.0 | 22.34 | 22.3 | MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. | R N Germain | Cell | 1994 | 8293464 | No |
| 2626 | 884 | 884.0 | 25.27 | 25.3 | Life, death, and the pursuit of apoptosis. | E White | Genes Dev. | 1996 | 8557188 | No |
| 2627 | 884 | 884.0 | 24.15 | 24.1 | Aptamers: an emerging class of molecules that rival antibodies in diagnostics. | S D Jayasena | Clin. Chem. | 1999 | 10471678 | No |
| 2628 | 1768 | 884.0 | 46.7 | 23.4 | Esophageal cancer. | Peter C Enzinger, Robert J Mayer | N. Engl. J. Med. | 2003 | 14657432 | No |
| 2629 | 883 | 883.0 | 39.81 | 39.8 | Inflammation in atherosclerosis. | Peter Libby | Arterioscler. Thromb. Vasc. Biol. | 2012 | 22895665 | No |
| 2630 | 882 | 882.0 | 0.0 | 0.0 | Strategy and tactics in protein chemistry. | B S Hartley | Biochem. J. | 1970 | 4923920 | No |
| 2631 | 882 | 882.0 | 20.45 | 20.4 | Osmotic stress signaling and osmoadaptation in yeasts. | Stefan Hohmann | Microbiol. Mol. Biol. Rev. | 2002 | 12040128 | No |
| 2632 | 1763 | 881.5 | 43.72 | 21.9 | Mitogen-activated protein kinase pathways. | M J Robinson, M H Cobb | Curr. Opin. Cell Biol. | 1997 | 9069255 | No |
| 2633 | 1763 | 881.5 | 49.8 | 24.9 | A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. | J N Cohn, G Tognoni | N. Engl. J. Med. | 2001 | 11759645 | Yes |
| 2634 | 881 | 881.0 | 22.66 | 22.7 | Complement. Second of two parts. | M J Walport | N. Engl. J. Med. | 2001 | 11297706 | No |
| 2635 | 2643 | 881.0 | 95.29 | 31.8 | Dose translation from animal to human studies revisited. | Shannon Reagan-Shaw, Minakshi Nihal, Nihal Ahmad | FASEB J. | 2008 | 17942826 | Yes |
| 2636 | 2642 | 880.7 | 98.15 | 32.7 | Simultaneous inference in general parametric models. | Torsten Hothorn, Frank Bretz, Peter Westfall | Biom J | 2008 | 18481363 | No |
| 2637 | 880 | 880.0 | 0.0 | 0.0 | Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. | S Avrameas | Immunochemistry | 1969 | 4975324 | Yes |
| 2638 | 880 | 880.0 | 0.0 | 0.0 | Studies on phosphatidylcholine vesicles. Formation and physical characteristics. | C Huang | Biochemistry | 1969 | 5777332 | Yes |
| 2639 | 880 | 880.0 | 63.38 | 63.4 | Rating scales to assess depression in school-aged children. | M Kovacs | Acta Paedopsychiatr | 1981 | 7025571 | Yes |
| 2640 | 880 | 880.0 | 39.83 | 39.8 | Multimodal approach to control postoperative pathophysiology and rehabilitation. | H Kehlet | Br J Anaesth | 1997 | 9175983 | No |
| 2641 | 1759 | 879.5 | 0.0 | 0.0 | Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. | E Engvall, P Perlmann | J. Immunol. | 1972 | 4113792 | Yes |
| 2642 | 1759 | 879.5 | 46.49 | 23.2 | Quorum sensing in bacteria. | M B Miller, B L Bassler | Annu. Rev. Microbiol. | 2001 | 11544353 | No |
| 2643 | 1759 | 879.5 | 41.41 | 20.7 | Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. | S W Hell, J Wichmann | Opt Lett | 1994 | 19844443 | Yes |
| 2644 | 879 | 879.0 | 31.14 | 31.1 | Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. | E N Bergman | Physiol. Rev. | 1990 | 2181501 | No |
| 2645 | 879 | 879.0 | 61.38 | 61.4 | The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. | G A Ilizarov | Clin. Orthop. Relat. Res. | 1989 | 2912628 | Yes |
| 2646 | 879 | 879.0 | 0.0 | 0.0 | Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. | P O Seglen | Exp. Cell Res. | 1973 | 4358115 | Yes |
| 2647 | 1758 | 879.0 | 95.16 | 47.6 | Rapid procedure for detection and isolation of large and small plasmids. | C I Kado, S T Liu | J. Bacteriol. | 1981 | 7009583 | Yes |
| 2648 | 879 | 879.0 | 23.65 | 23.6 | SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. | S V Evans | J Mol Graph | 1993 | 8347566 | Yes |
| 2649 | 1758 | 879.0 | 37.42 | 18.7 | Wnt signaling: a common theme in animal development. | K M Cadigan, R Nusse | Genes Dev. | 1997 | 9407023 | No |
| 2650 | 879 | 879.0 | 21.34 | 21.3 | Oxidant signals and oxidative stress. | Toren Finkel | Curr. Opin. Cell Biol. | 2003 | 12648682 | No |
| 2651 | 1758 | 879.0 | 51.77 | 25.9 | Drug delivery systems: entering the mainstream. | Theresa M Allen, Pieter R Cullis | Science | 2004 | 15031496 | Yes |
| 2652 | 879 | 879.0 | 0.0 | 0.0 | A new readability yardstick. | R FLESCH | J Appl Psychol | 1948 | 18867058 | Yes |
| 2653 | 879 | 879.0 | 46.66 | 46.7 | Cognitive reserve in ageing and Alzheimer's disease. | Yaakov Stern | Lancet Neurol | 2012 | 23079557 | No |
| 2654 | 2635 | 878.3 | 57.15 | 19.1 | The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. | Fabio Martinon, Kimberly Burns, Jürg Tschopp | Mol. Cell | 2002 | 12191486 | Yes |
| 2655 | 4391 | 878.2 | 276.7 | 55.3 | Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. | N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W Stitt | J. Rheumatol. | 1988 | 3068365 | Yes |
| 2656 | 3513 | 878.2 | 93.48 | 23.4 | Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. | G L Wang, B H Jiang, E A Rue, G L Semenza | Proc. Natl. Acad. Sci. U.S.A. | 1995 | 7539918 | Yes |
| 2657 | 5269 | 878.2 | 150.83 | 25.1 | GROMACS: fast, flexible, and free. | David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C Berendsen | J Comput Chem | 2005 | 16211538 | Yes |
| 2658 | 1756 | 878.0 | 38.11 | 19.1 | CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. | A M Thornton, E M Shevach | J. Exp. Med. | 1998 | 9670041 | Yes |
| 2659 | 1756 | 878.0 | 66.28 | 33.1 | A cognitive model of posttraumatic stress disorder. | A Ehlers, D M Clark | Behav Res Ther | 2000 | 10761279 | No |
| 2660 | 878 | 878.0 | 24.26 | 24.3 | Current concepts of the pathogenesis of the acute coronary syndromes. | P Libby | Circulation | 2001 | 11457759 | No |
| 2661 | 878 | 878.0 | 19.62 | 19.6 | mTOR and cancer: insights into a complex relationship. | David M Sabatini | Nat. Rev. Cancer | 2006 | 16915295 | No |
| 2662 | 878 | 878.0 | 28.02 | 28.0 | Persister cells, dormancy and infectious disease. | Kim Lewis | Nat. Rev. Microbiol. | 2007 | 17143318 | No |
| 2663 | 1755 | 877.5 | 57.72 | 28.9 | Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. | M A Pfeffer, E Braunwald | Circulation | 1990 | 2138525 | No |
| 2664 | 1754 | 877.0 | 0.0 | 0.0 | A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. | R L Juliano, V Ling | Biochim. Biophys. Acta | 1976 | 990323 | Yes |
| 2665 | 877 | 877.0 | 0.0 | 0.0 | Experience from a multicentre stroke register: a preliminary report. | S Hatano | Bull. World Health Organ. | 1976 | 1088404 | Yes |
| 2666 | 877 | 877.0 | 0.0 | 0.0 | Relative and absolute strength of response as a function of frequency of reinforcement. | R J HERRNSTEIN | J Exp Anal Behav | 1961 | 13713775 | Yes |
| 2667 | 876 | 876.0 | 32.99 | 33.0 | Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. | F Hefti | J. Neurosci. | 1986 | 3746405 | Yes |
| 2668 | 876 | 876.0 | 22.37 | 22.4 | The columnar organization of the neocortex. | V B Mountcastle | Brain | 1997 | 9153131 | No |
| 2669 | 1752 | 876.0 | 42.41 | 21.2 | The significance of digital gene expression profiles. | S Audic, J M Claverie | Genome Res. | 1997 | 9331369 | Yes |
| 2670 | 876 | 876.0 | 23.72 | 23.7 | Natural history of chronic hepatitis C. | Leonard B Seeff | Hepatology | 2002 | 12407575 | No |
| 2671 | 876 | 876.0 | 31.9 | 31.9 | Water as an active constituent in cell biology. | Philip Ball | Chem. Rev. | 2008 | 18095715 | No |
| 2672 | 1750 | 875.0 | 0.0 | 0.0 | Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. | E Engvall, P Perlmann | Immunochemistry | 1971 | 5135623 | Yes |
| 2673 | 875 | 875.0 | 16.3 | 16.3 | Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. | Eric C Lai | Nat. Genet. | 2002 | 11896390 | Yes |
| 2674 | 1750 | 875.0 | 67.4 | 33.7 | Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. | S Geman, D Geman | IEEE Trans Pattern Anal Mach Intell | 1984 | 22499653 | Yes |
| 2675 | 1749 | 874.5 | 0.0 | 0.0 | Brain stem reticular formation and activation of the EEG. | G Moruzzi, H W Magoun | Electroencephalogr Clin Neurophysiol | 1949 | 18421835 | Yes |
| 2676 | 874 | 874.0 | 25.55 | 25.6 | Tumor suppressor genes. | R A Weinberg | Science | 1991 | 1659741 | No |
| 2677 | 5244 | 874.0 | 229.94 | 38.3 | The occurrence of sleep-disordered breathing among middle-aged adults. | T Young, M Palta, J Dempsey, J Skatrud, S Weber, S Badr | N. Engl. J. Med. | 1993 | 8464434 | Yes |
| 2678 | 874 | 874.0 | 29.83 | 29.8 | Disseminating innovations in health care. | Donald M Berwick | JAMA | 2003 | 12697800 | Yes |
| 2679 | 874 | 874.0 | 23.21 | 23.2 | A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. | Lawrence Steinman | Nat. Med. | 2007 | 17290272 | No |
| 2680 | 873 | 873.0 | 32.97 | 33.0 | Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. | L A Liotta | Cancer Res. | 1986 | 2998604 | No |
| 2681 | 873 | 873.0 | 0.0 | 0.0 | The interaction of a naphthalene dye with apomyoglobin and apohemoglobin. A fluorescent probe of non-polar binding sites. | L Stryer | J. Mol. Biol. | 1965 | 5867031 | Yes |
| 2682 | 873 | 873.0 | 41.54 | 41.5 | The structure of beta-lactamases. | R P Ambler | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | 1980 | 6109327 | Yes |
| 2683 | 873 | 873.0 | 41.52 | 41.5 | Carnitine--metabolism and functions. | J Bremer | Physiol. Rev. | 1983 | 6361812 | No |
| 2684 | 2619 | 873.0 | 107.25 | 35.8 | Qualitative research in health care. Analysing qualitative data. | C Pope, S Ziebland, N Mays | BMJ | 2000 | 10625273 | No |
| 2685 | 873 | 873.0 | 22.46 | 22.5 | Target-oriented and diversity-oriented organic synthesis in drug discovery. | S L Schreiber | Science | 2000 | 10720315 | No |
| 2686 | 873 | 873.0 | 0.0 | 0.0 | LINKED FUNCTIONS AND RECIPROCAL EFFECTS IN HEMOGLOBIN: A SECOND LOOK. | J WYMAN | Adv. Protein Chem. | 1964 | 14268785 | No |
| 2687 | 1746 | 873.0 | 46.0 | 23.0 | Blinded by the Light: The Growing Complexity of p53. | Karen H Vousden, Carol Prives | Cell | 2009 | 19410540 | No |
| 2688 | 873 | 873.0 | 51.28 | 51.3 | Whatever next? Predictive brains, situated agents, and the future of cognitive science. | Andy Clark | Behav Brain Sci | 2013 | 23663408 | No |
| 2689 | 873 | 873.0 | 80.04 | 80.0 | The antibiotic resistance crisis: part 1: causes and threats. | C Lee Ventola | P T | 2015 | 25859123 | Yes |
| 2690 | 2618 | 872.7 | 78.59 | 26.2 | Membrane lipids: where they are and how they behave. | Gerrit van Meer, Dennis R Voelker, Gerald W Feigenson | Nat. Rev. Mol. Cell Biol. | 2008 | 18216768 | No |
| 2691 | 1745 | 872.5 | 64.93 | 32.5 | Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. | Aluísio J D Barros, Vânia N Hirakata | BMC Med Res Methodol | 2003 | 14567763 | Yes |
| 2692 | 872 | 872.0 | 0.0 | 0.0 | Origin of concatemeric T7 DNA. | J D Watson | Nature New Biol. | 1972 | 4507727 | Yes |
| 2693 | 872 | 872.0 | 26.98 | 27.0 | Disorders of iron metabolism. | N C Andrews | N. Engl. J. Med. | 1999 | 10607817 | No |
| 2694 | 1744 | 872.0 | 0.0 | 0.0 | A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. | A H ANTON, D F SAYRE | J. Pharmacol. Exp. Ther. | 1962 | 14013351 | Yes |
| 2695 | 872 | 872.0 | 21.77 | 21.8 | Membrane recognition by phospholipid-binding domains. | Mark A Lemmon | Nat. Rev. Mol. Cell Biol. | 2008 | 18216767 | No |
| 2696 | 872 | 872.0 | 36.95 | 37.0 | The epidemiology of adult obstructive sleep apnea. | Naresh M Punjabi | Proc Am Thorac Soc | 2008 | 18250205 | No |
| 2697 | 871 | 871.0 | 40.69 | 40.7 | A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. | S T Tiffany | Psychol Rev | 1990 | 2186423 | No |
| 2698 | 871 | 871.0 | 28.14 | 28.1 | Linkage strategies for genetically complex traits. I. Multilocus models. | N Risch | Am. J. Hum. Genet. | 1990 | 2301392 | Yes |
| 2699 | 871 | 871.0 | 24.41 | 24.4 | Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. | P Kuzmic | Anal. Biochem. | 1996 | 8660575 | Yes |
| 2700 | 5226 | 871.0 | 135.23 | 22.5 | Principal components analysis corrects for stratification in genome-wide association studies. | Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David Reich | Nat. Genet. | 2006 | 16862161 | Yes |
| 2701 | 4351 | 870.2 | 185.33 | 37.1 | Posttraumatic stress disorder in the National Comorbidity Survey. | R C Kessler, A Sonnega, E Bromet, M Hughes, C B Nelson | Arch. Gen. Psychiatry | 1995 | 7492257 | Yes |
| 2702 | 870 | 870.0 | 37.81 | 37.8 | Density matrix formulation for quantum renormalization groups. | White | Phys. Rev. Lett. | 1992 | 10046608 | Yes |
| 2703 | 870 | 870.0 | 23.31 | 23.3 | Plant salt tolerance. | J K Zhu | Trends Plant Sci. | 2001 | 11173290 | Yes |
| 2704 | 870 | 870.0 | 0.0 | 0.0 | The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. | S V BOYDEN | J. Exp. Med. | 1951 | 14803635 | Yes |
| 2705 | 2610 | 870.0 | 77.42 | 25.8 | Functional porous coordination polymers. | Susumu Kitagawa, Ryo Kitaura, Shin-ichiro Noro | Angew. Chem. Int. Ed. Engl. | 2004 | 15114565 | Yes |
| 2706 | 870 | 870.0 | 19.47 | 19.5 | ChIP-seq: advantages and challenges of a maturing technology. | Peter J Park | Nat. Rev. Genet. | 2009 | 19736561 | No |
| 2707 | 4348 | 869.6 | 183.18 | 36.6 | Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. | J S Beckman, T W Beckman, J Chen, P A Marshall, B A Freeman | Proc. Natl. Acad. Sci. U.S.A. | 1990 | 2154753 | Yes |
| 2708 | 1739 | 869.5 | 40.49 | 20.2 | Homeobox genes and axial patterning. | W McGinnis, R Krumlauf | Cell | 1992 | 1346368 | No |
| 2709 | 869 | 869.0 | 25.45 | 25.4 | Chemistry and biology of the immunophilins and their immunosuppressive ligands. | S L Schreiber | Science | 1991 | 1702904 | No |
| 2710 | 869 | 869.0 | 57.82 | 57.8 | ROC methodology in radiologic imaging. | C E Metz | Invest Radiol | 1986 | 3095258 | No |
| 2711 | 869 | 869.0 | 23.93 | 23.9 | Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. | J Denis McGarry | Diabetes | 2002 | 11756317 | No |
| 2712 | 1738 | 869.0 | 55.96 | 28.0 | Biology of incretins: GLP-1 and GIP. | Laurie L Baggio, Daniel J Drucker | Gastroenterology | 2007 | 17498508 | No |
| 2713 | 2605 | 868.3 | 65.99 | 22.0 | Generation of germline-competent induced pluripotent stem cells. | Keisuke Okita, Tomoko Ichisaka, Shinya Yamanaka | Nature | 2007 | 17554338 | Yes |
| 2714 | 868 | 868.0 | 41.66 | 41.7 | Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. | R M Post | Am J Psychiatry | 1992 | 1353322 | No |
| 2715 | 868 | 868.0 | 0.0 | 0.0 | Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. | J A Miller | Cancer Res. | 1970 | 4915745 | No |
| 2716 | 868 | 868.0 | 56.84 | 56.8 | Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. | A M Carlsson | Pain | 1983 | 6602967 | Yes |
| 2717 | 868 | 868.0 | 38.02 | 38.0 | Checklists for improving rigour in qualitative research: a case of the tail wagging the dog? | R S Barbour | BMJ | 2001 | 11337448 | No |
| 2718 | 868 | 868.0 | 27.1 | 27.1 | N-heterocyclic carbenes: a new concept in organometallic catalysis. | Wolfgang A Herrmann | Angew. Chem. Int. Ed. Engl. | 2002 | 19750753 | Yes |
| 2719 | 2602 | 867.3 | 76.19 | 25.4 | Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. | Y Zhang, M Brady, S Smith | IEEE Trans Med Imaging | 2001 | 11293691 | Yes |
| 2720 | 867 | 867.0 | 45.57 | 45.6 | Bone "mass" and the "mechanostat": a proposal. | H M Frost | Anat. Rec. | 1987 | 3688455 | Yes |
| 2721 | 867 | 867.0 | 0.0 | 0.0 | Structure and function of intercellular junctions. | L A Staehelin | Int. Rev. Cytol. | 1974 | 4611943 | No |
| 2722 | 867 | 867.0 | 38.5 | 38.5 | The phenomenon of the acute phase response. | I Kushner | Ann. N. Y. Acad. Sci. | 1982 | 7046585 | No |
| 2723 | 1734 | 867.0 | 53.52 | 26.8 | Molecular mechanisms of action of steroid/thyroid receptor superfamily members. | M J Tsai, B W O'Malley | Annu. Rev. Biochem. | 1994 | 7979245 | No |
| 2724 | 867 | 867.0 | 31.14 | 31.1 | The somatic marker hypothesis and the possible functions of the prefrontal cortex. | A R Damasio | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | 1996 | 8941953 | No |
| 2725 | 867 | 867.0 | 19.84 | 19.8 | Automated NMR structure calculation with CYANA. | Peter Güntert | Methods Mol. Biol. | 2004 | 15318003 | Yes |
| 2726 | 1734 | 867.0 | 66.19 | 33.1 | An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. | O Johnell, J A Kanis | Osteoporos Int | 2006 | 16983459 | Yes |
| 2727 | 1732 | 866.0 | 45.35 | 22.7 | A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. | C S Hoffman, F Winston | Gene | 1987 | 3319781 | Yes |
| 2728 | 866 | 866.0 | 21.37 | 21.4 | GLIA: listening and talking to the synapse. | P G Haydon | Nat. Rev. Neurosci. | 2001 | 11256079 | No |
| 2729 | 866 | 866.0 | 22.03 | 22.0 | Molecular imaging of cancer with positron emission tomography. | Sanjiv Sam Gambhir | Nat. Rev. Cancer | 2002 | 12209157 | No |
| 2730 | 866 | 866.0 | 29.54 | 29.5 | Infection in solid-organ transplant recipients. | Jay A Fishman | N. Engl. J. Med. | 2007 | 18094380 | No |
| 2731 | 1731 | 865.5 | 0.0 | 0.0 | Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. | A Fabiato, F Fabiato | J. Physiol. (Paris) | 1979 | 533865 | Yes |
| 2732 | 1731 | 865.5 | 63.07 | 31.5 | Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. | P Brugada, J Brugada | J. Am. Coll. Cardiol. | 1992 | 1309182 | Yes |
| 2733 | 865 | 865.0 | 36.14 | 36.1 | Selective attention and the organization of visual information. | J Duncan | J Exp Psychol Gen | 1984 | 6240521 | Yes |
| 2734 | 865 | 865.0 | 17.94 | 17.9 | The ubiquitin-proteasome pathway: on protein death and cell life. | A Ciechanover | EMBO J. | 1998 | 9857172 | No |
| 2735 | 1730 | 865.0 | 32.58 | 16.3 | A synthetic oscillatory network of transcriptional regulators. | M B Elowitz, S Leibler | Nature | 2000 | 10659856 | Yes |
| 2736 | 865 | 865.0 | 22.35 | 22.4 | How neutrophils kill microbes. | Anthony W Segal | Annu. Rev. Immunol. | 2005 | 15771570 | No |
| 2737 | 1729 | 864.5 | 63.27 | 31.6 | Excitatory amino acids as a final common pathway for neurologic disorders. | S A Lipton, P A Rosenberg | N. Engl. J. Med. | 1994 | 7905600 | No |
| 2738 | 1727 | 863.5 | 52.69 | 26.3 | The protective effects of estrogen on the cardiovascular system. | M E Mendelsohn, R H Karas | N. Engl. J. Med. | 1999 | 10362825 | No |
| 2739 | 863 | 863.0 | 26.46 | 26.5 | The Trk family of neurotrophin receptors. | M Barbacid | J. Neurobiol. | 1994 | 7852993 | No |
| 2740 | 863 | 863.0 | 32.09 | 32.1 | Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. | M E Bouton | Psychol Bull | 1993 | 8346330 | No |
| 2741 | 863 | 863.0 | 23.52 | 23.5 | Signal transduction via the MAP kinases: proceed at your own RSK. | J Blenis | Proc. Natl. Acad. Sci. U.S.A. | 1993 | 8392180 | No |
| 2742 | 863 | 863.0 | 40.98 | 41.0 | UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. | D W Russell | J Pers Assess | 1996 | 8576833 | Yes |
| 2743 | 863 | 863.0 | 20.05 | 20.1 | An overview of epithelio-mesenchymal transformation. | E D Hay | Acta Anat (Basel) | 1995 | 8714286 | No |
| 2744 | 863 | 863.0 | 21.95 | 21.9 | BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data. | O Gascuel | Mol. Biol. Evol. | 1997 | 9254330 | Yes |
| 2745 | 863 | 863.0 | 18.98 | 19.0 | Initiation of translation in prokaryotes and eukaryotes. | M Kozak | Gene | 1999 | 10395892 | No |
| 2746 | 863 | 863.0 | 19.22 | 19.2 | Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. | A S Baldwin | J. Clin. Invest. | 2001 | 11160144 | No |
| 2747 | 863 | 863.0 | 22.62 | 22.6 | New ideas about atrial fibrillation 50 years on. | Stanley Nattel | Nature | 2002 | 11805846 | No |
| 2748 | 863 | 863.0 | 0.0 | 0.0 | A NEW WEIGHTING SYSTEM FOR MEAN SURFACE TEMPERATURE OF THE HUMAN BODY. | N L RAMANATHAN | J Appl Physiol | 1964 | 14173555 | Yes |
| 2749 | 863 | 863.0 | 0.0 | 0.0 | The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. | S HESTRIN | J. Biol. Chem. | 1949 | 18133390 | Yes |
| 2750 | 862 | 862.0 | 0.0 | 0.0 | The anterior approach for removal of ruptured cervical disks. | R B CLOWARD | J. Neurosurg. | 1958 | 13599052 | Yes |
| 2751 | 1724 | 862.0 | 48.04 | 24.0 | Modes of resistance to anti-angiogenic therapy. | Gabriele Bergers, Douglas Hanahan | Nat. Rev. Cancer | 2008 | 18650835 | No |
| 2752 | 1724 | 862.0 | 170.34 | 85.2 | Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. | Ivica Letunic, Peer Bork | Nucleic Acids Res. | 2016 | 27095192 | Yes |
| 2753 | 2585 | 861.7 | 80.46 | 26.8 | A nonparametric method for automatic correction of intensity nonuniformity in MRI data. | J G Sled, A P Zijdenbos, A C Evans | IEEE Trans Med Imaging | 1998 | 9617910 | Yes |
| 2754 | 1723 | 861.5 | 71.56 | 35.8 | Role of oxidized low density lipoprotein in atherogenesis. | J L Witztum, D Steinberg | J. Clin. Invest. | 1991 | 1752940 | No |
| 2755 | 861 | 861.0 | 40.22 | 40.2 | Spatial localization in NMR spectroscopy in vivo. | P A Bottomley | Ann. N. Y. Acad. Sci. | 1987 | 3326459 | No |
| 2756 | 1722 | 861.0 | 28.59 | 14.3 | Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. | T Lee, L Luo | Neuron | 1999 | 10197526 | Yes |
| 2757 | 861 | 861.0 | 32.96 | 33.0 | Spatially heterogeneous dynamics in supercooled liquids. | M D Ediger | Annu Rev Phys Chem | 2000 | 11031277 | Yes |
| 2758 | 861 | 861.0 | 34.37 | 34.4 | Platelet-rich plasma: evidence to support its use. | Robert E Marx | J. Oral Maxillofac. Surg. | 2004 | 15085519 | No |
| 2759 | 861 | 861.0 | 24.2 | 24.2 | Anatomy and regulation of the central melanocortin system. | Roger D Cone | Nat. Neurosci. | 2005 | 15856065 | No |
| 2760 | 1721 | 860.5 | 75.91 | 38.0 | Atomic structure and chemistry of human serum albumin. | X M He, D C Carter | Nature | 1992 | 1630489 | Yes |
| 2761 | 1721 | 860.5 | 63.64 | 31.8 | A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. | A Ennaceur, J Delacour | Behav. Brain Res. | 1988 | 3228475 | Yes |
| 2762 | 1721 | 860.5 | 0.0 | 0.0 | Immunoassay of insulin with insulin-antibody precipitate. | C N HALES, P J RANDLE | Biochem. J. | 1963 | 13952078 | Yes |
| 2763 | 2581 | 860.3 | 121.45 | 40.5 | Hepatocellular carcinoma. | Alejandro Forner, Josep M Llovet, Jordi Bruix | Lancet | 2012 | 22353262 | No |
| 2764 | 860 | 860.0 | 0.0 | 0.0 | Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. | M P Blaustein | Am. J. Physiol. | 1977 | 324293 | No |
| 2765 | 860 | 860.0 | 28.0 | 28.0 | The mitochondrial electron transport and oxidative phosphorylation system. | Y Hatefi | Annu. Rev. Biochem. | 1985 | 2862839 | No |
| 2766 | 1720 | 860.0 | 92.76 | 46.4 | Statistical methods in cancer research. Volume I - The analysis of case-control studies. | N E Breslow, N E Day | IARC Sci. Publ. | 1980 | 7216345 | Yes |
| 2767 | 860 | 860.0 | 20.85 | 20.9 | Up on the tightrope: natural killer cell activation and inhibition. | Lewis L Lanier | Nat. Immunol. | 2008 | 18425106 | No |
| 2768 | 1719 | 859.5 | 75.96 | 38.0 | Physiological parameters in laboratory animals and humans. | B Davies, T Morris | Pharm. Res. | 1993 | 8378254 | No |
| 2769 | 859 | 859.0 | 43.26 | 43.3 | Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. | S Katz | J Am Geriatr Soc | 1983 | 6418786 | No |
| 2770 | 859 | 859.0 | 23.11 | 23.1 | A tension-based theory of morphogenesis and compact wiring in the central nervous system. | D C Van Essen | Nature | 1997 | 9002514 | Yes |
| 2771 | 4290 | 858.0 | 130.82 | 26.2 | Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. | T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L Coffman | J. Immunol. | 1986 | 2419430 | Yes |
| 2772 | 858 | 858.0 | 25.08 | 25.1 | A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. | J Milbrandt | Science | 1987 | 3672127 | Yes |
| 2773 | 858 | 858.0 | 25.39 | 25.4 | Looking into the functional architecture of the brain with diffusion MRI. | Denis Le Bihan | Nat. Rev. Neurosci. | 2003 | 12778119 | No |
| 2774 | 858 | 858.0 | 25.25 | 25.2 | Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis. | Peter Fransson | Hum Brain Mapp | 2005 | 15852468 | Yes |
| 2775 | 858 | 858.0 | 0.0 | 0.0 | Antigen-antibody reactions in gels. | O OUCHTERLONY | Acta Pathol Microbiol Scand | 1949 | 18143039 | Yes |
| 2776 | 5146 | 857.7 | 160.85 | 26.8 | Prediction of coronary heart disease using risk factor categories. | P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B Kannel | Circulation | 1998 | 9603539 | Yes |
| 2777 | 1714 | 857.0 | 65.34 | 32.7 | Quality control and preprocessing of metagenomic datasets. | Robert Schmieder, Robert Edwards | Bioinformatics | 2011 | 21278185 | Yes |
| 2778 | 1714 | 857.0 | 0.0 | 0.0 | Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. | Zunyou Wu, Jennifer M McGoogan | JAMA | 2020 | 32091533 | Yes |
| 2779 | 1713 | 856.5 | 52.75 | 26.4 | Protein oxidation in aging, disease, and oxidative stress. | B S Berlett, E R Stadtman | J. Biol. Chem. | 1997 | 9252331 | No |
| 2780 | 856 | 856.0 | 56.62 | 56.6 | A "rationalized" arcsine transform. | G A Studebaker | J Speech Hear Res | 1985 | 4046587 | Yes |
| 2781 | 856 | 856.0 | 54.61 | 54.6 | Derivation and validation of a short-form oral health impact profile. | G D Slade | Community Dent Oral Epidemiol | 1997 | 9332805 | Yes |
| 2782 | 1712 | 856.0 | 46.09 | 23.0 | Emerging roles of caspase-3 in apoptosis. | A G Porter, R U Jänicke | Cell Death Differ. | 1999 | 10200555 | No |
| 2783 | 5131 | 855.2 | 130.24 | 21.7 | Obesity is associated with macrophage accumulation in adipose tissue. | Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W Ferrante | J. Clin. Invest. | 2003 | 14679176 | Yes |
| 2784 | 855 | 855.0 | 0.0 | 0.0 | Transformation of yeast by a replicating hybrid plasmid. | J D Beggs | Nature | 1978 | 357984 | Yes |
| 2785 | 855 | 855.0 | 26.25 | 26.2 | Supported membranes: scientific and practical applications. | E Sackmann | Science | 1996 | 8539599 | No |
| 2786 | 1710 | 855.0 | 32.36 | 16.2 | Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. | W Gu, R G Roeder | Cell | 1997 | 9288740 | Yes |
| 2787 | 855 | 855.0 | 27.54 | 27.5 | Inhibition of return. | Klein | Trends Cogn. Sci. (Regul. Ed.) | 2000 | 10740278 | Yes |
| 2788 | 3420 | 855.0 | 98.68 | 24.7 | Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. | Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod Menon | Proc. Natl. Acad. Sci. U.S.A. | 2003 | 12506194 | Yes |
| 2789 | 3420 | 855.0 | 99.14 | 24.8 | The epidemiology of sepsis in the United States from 1979 through 2000. | Greg S Martin, David M Mannino, Stephanie Eaton, Marc Moss | N. Engl. J. Med. | 2003 | 12700374 | Yes |
| 2790 | 1710 | 855.0 | 38.09 | 19.0 | Tumour-cell invasion and migration: diversity and escape mechanisms. | Peter Friedl, Katarina Wolf | Nat. Rev. Cancer | 2003 | 12724734 | No |
| 2791 | 1710 | 855.0 | 50.15 | 25.1 | Principles of bioactive lipid signalling: lessons from sphingolipids. | Yusuf A Hannun, Lina M Obeid | Nat. Rev. Mol. Cell Biol. | 2008 | 18216770 | No |
| 2792 | 1710 | 855.0 | 58.45 | 29.2 | Integrins in cancer: biological implications and therapeutic opportunities. | Jay S Desgrosellier, David A Cheresh | Nat. Rev. Cancer | 2010 | 20029421 | No |
| 2793 | 855 | 855.0 | 32.51 | 32.5 | Persister cells. | Kim Lewis | Annu. Rev. Microbiol. | 2010 | 20528688 | No |
| 2794 | 855 | 855.0 | 37.19 | 37.2 | The amazing osteocyte. | Lynda F Bonewald | J. Bone Miner. Res. | 2011 | 21254230 | No |
| 2795 | 3417 | 854.2 | 117.57 | 29.4 | Toxic potential of materials at the nanolevel. | Andre Nel, Tian Xia, Lutz Mädler, Ning Li | Science | 2006 | 16456071 | No |
| 2796 | 854 | 854.0 | 60.69 | 60.7 | Psychosocial resilience and protective mechanisms. | Michael Rutter | Am J Orthopsychiatry | 1987 | 3303954 | No |
| 2797 | 854 | 854.0 | 21.4 | 21.4 | The enzymes, regulation, and genetics of bile acid synthesis. | David W Russell | Annu. Rev. Biochem. | 2003 | 12543708 | No |
| 2798 | 2562 | 854.0 | 0.0 | 0.0 | Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. | D D SABATINI, K BENSCH, R J BARRNETT | J. Cell Biol. | 1963 | 13975866 | Yes |
| 2799 | 1708 | 854.0 | 0.0 | 0.0 | Chronic catheterization of the spinal subarachnoid space. | T L Yaksh, T A Rudy | Physiol. Behav. | 1976 | 14677603 | Yes |
| 2800 | 1708 | 854.0 | 55.57 | 27.8 | ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control. | Graham Noctor, Christine H. Foyer | Annu. Rev. Plant Physiol. Plant Mol. Biol. | 1998 | 15012235 | Yes |
| 2801 | 3414 | 853.5 | 100.56 | 25.1 | An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. | Joseph A Maldjian, Paul J Laurienti, Robert A Kraft, Jonathan H Burdette | Neuroimage | 2003 | 12880848 | Yes |
| 2802 | 1707 | 853.5 | 76.89 | 38.4 | How useful is SBF in predicting in vivo bone bioactivity? | Tadashi Kokubo, Hiroaki Takadama | Biomaterials | 2006 | 16448693 | No |
| 2803 | 1706 | 853.0 | 74.68 | 37.3 | Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. | A E Czeizel, I Dudás | N. Engl. J. Med. | 1992 | 1307234 | Yes |
| 2804 | 853 | 853.0 | 0.0 | 0.0 | Displaced proximal humeral fractures. I. Classification and evaluation. | C S Neer | J Bone Joint Surg Am | 1970 | 5455339 | Yes |
| 2805 | 1706 | 853.0 | 43.45 | 21.7 | Long-term potentiation--a decade of progress? | R C Malenka, R A Nicoll | Science | 1999 | 10489359 | No |
| 2806 | 1706 | 853.0 | 43.67 | 21.8 | Regeneration beyond the glial scar. | Jerry Silver, Jared H Miller | Nat. Rev. Neurosci. | 2004 | 14735117 | No |
| 2807 | 853 | 853.0 | 31.59 | 31.6 | Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. | Felix Kratz | J Control Release | 2008 | 18582981 | No |
| 2808 | 852 | 852.0 | 40.82 | 40.8 | The P300 wave of the human event-related potential. | T W Picton | J Clin Neurophysiol | 1992 | 1464675 | No |
| 2809 | 852 | 852.0 | 25.75 | 25.8 | Two-stage model of memory trace formation: a role for "noisy" brain states. | G Buzsáki | Neuroscience | 1989 | 2687720 | No |
| 2810 | 852 | 852.0 | 22.71 | 22.7 | ECM and cell surface proteolysis: regulating cellular ecology. | Z Werb | Cell | 1997 | 9390552 | No |
| 2811 | 852 | 852.0 | 35.41 | 35.4 | Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. | Ronald A Hites | Environ. Sci. Technol. | 2004 | 14998004 | Yes |
| 2812 | 852 | 852.0 | 31.6 | 31.6 | G(ST) and its relatives do not measure differentiation. | Lou Jost | Mol. Ecol. | 2008 | 19238703 | Yes |
| 2813 | 852 | 852.0 | 0.0 | 0.0 | An approximate distribution of estimates of variance components. | F E SATTERTHWAITE | Biometrics | 1946 | 20287815 | Yes |
| 2814 | 1702 | 851.0 | 0.0 | 0.0 | High resolution acrylamide gel electrophoresis of histones. | S Panyim, R Chalkley | Arch. Biochem. Biophys. | 1969 | 5778650 | Yes |
| 2815 | 851 | 851.0 | 17.4 | 17.4 | Chronic myeloid leukemia. | C L Sawyers | N. Engl. J. Med. | 1999 | 10219069 | No |
| 2816 | 851 | 851.0 | 39.23 | 39.2 | A review of psychological risk factors in back and neck pain. | S J Linton | Spine | 2000 | 10788861 | No |
| 2817 | 1701 | 850.5 | 157.01 | 78.5 | Facial nerve grading system. | J W House, D E Brackmann | Otolaryngol Head Neck Surg | 1985 | 3921901 | Yes |
| 2818 | 850 | 850.0 | 47.52 | 47.5 | How is the level of free arachidonic acid controlled in mammalian cells? | R F Irvine | Biochem. J. | 1982 | 6810878 | No |
| 2819 | 850 | 850.0 | 20.83 | 20.8 | mRNA stability in mammalian cells. | J Ross | Microbiol. Rev. | 1995 | 7565413 | No |
| 2820 | 1700 | 850.0 | 37.08 | 18.5 | Proliferation, cell cycle and apoptosis in cancer. | G I Evan, K H Vousden | Nature | 2001 | 11357141 | No |
| 2821 | 850 | 850.0 | 0.0 | 0.0 | A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. | D MATTINGLY | J. Clin. Pathol. | 1962 | 14471419 | Yes |
| 2822 | 850 | 850.0 | 20.19 | 20.2 | Gene finding in novel genomes. | Ian Korf | BMC Bioinformatics | 2004 | 15144565 | Yes |
| 2823 | 850 | 850.0 | 19.0 | 19.0 | Telomeres and human disease: ageing, cancer and beyond. | Maria A Blasco | Nat. Rev. Genet. | 2005 | 16136653 | No |
| 2824 | 850 | 850.0 | 26.55 | 26.6 | Mitochondrial fusion and fission in cell life and death. | Benedikt Westermann | Nat. Rev. Mol. Cell Biol. | 2010 | 21102612 | No |
| 2825 | 1699 | 849.5 | 0.0 | 0.0 | Further improvements in the plaque technique for detecting single antibody-forming cells. | A J Cunningham, A Szenberg | Immunology | 1968 | 5653817 | Yes |
| 2826 | 849 | 849.0 | 0.0 | 0.0 | Electrophoretic separation of plasma lipoproteins in agarose gel. | R P Noble | J. Lipid Res. | 1968 | 4176473 | Yes |
| 2827 | 849 | 849.0 | 28.69 | 28.7 | Aging, energy, and oxidative stress in neurodegenerative diseases. | M F Beal | Ann. Neurol. | 1995 | 7668820 | No |
| 2828 | 849 | 849.0 | 28.43 | 28.4 | Limbic-cortical dysregulation: a proposed model of depression. | H S Mayberg | J Neuropsychiatry Clin Neurosci | 1997 | 9276848 | No |
| 2829 | 1697 | 848.5 | 39.97 | 20.0 | Dynamic instability of microtubule growth. | T Mitchison, M Kirschner | Nature | 1984 | 6504138 | Yes |
| 2830 | 2545 | 848.3 | 87.27 | 29.1 | Spirometric reference values from a sample of the general U.S. population. | J L Hankinson, J R Odencrantz, K B Fedan | Am. J. Respir. Crit. Care Med. | 1999 | 9872837 | Yes |
| 2831 | 848 | 848.0 | 0.0 | 0.0 | Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. | U Ungerstedt | Acta Physiol Scand Suppl | 1971 | 4332693 | Yes |
| 2832 | 848 | 848.0 | 28.66 | 28.7 | Presynaptic nicotinic ACh receptors. | S Wonnacott | Trends Neurosci. | 1997 | 9023878 | No |
| 2833 | 1696 | 848.0 | 37.71 | 18.9 | Cellular functions regulated by Src family kinases. | S M Thomas, J S Brugge | Annu. Rev. Cell Dev. Biol. | 1997 | 9442882 | No |
| 2834 | 848 | 848.0 | 23.0 | 23.0 | G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. | Jeffery T Davis | Angew. Chem. Int. Ed. Engl. | 2004 | 14755695 | No |
| 2835 | 848 | 848.0 | 16.69 | 16.7 | The anaphase promoting complex/cyclosome: a machine designed to destroy. | Jan-Michael Peters | Nat. Rev. Mol. Cell Biol. | 2006 | 16896351 | No |
| 2836 | 848 | 848.0 | 23.95 | 23.9 | Principles and challenges of genomewide DNA methylation analysis. | Peter W Laird | Nat. Rev. Genet. | 2010 | 20125086 | No |
| 2837 | 4238 | 847.6 | 93.92 | 18.8 | Electrostatics of nanosystems: application to microtubules and the ribosome. | N A Baker, D Sept, S Joseph, M J Holst, J A McCammon | Proc. Natl. Acad. Sci. U.S.A. | 2001 | 11517324 | Yes |
| 2838 | 847 | 847.0 | 28.87 | 28.9 | Pharmacology of cannabinoid CB1 and CB2 receptors. | R G Pertwee | Pharmacol. Ther. | 1997 | 9336020 | No |
| 2839 | 847 | 847.0 | 18.34 | 18.3 | Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins. | M D Resh | Biochim. Biophys. Acta | 1999 | 10446384 | No |
| 2840 | 846 | 846.0 | 0.0 | 0.0 | An approach for the treatment of penile carcinoma. | R M Cabanas | Cancer | 1977 | 837331 | Yes |
| 2841 | 1692 | 846.0 | 38.03 | 19.0 | Community structure in social and biological networks. | M Girvan, M E J Newman | Proc. Natl. Acad. Sci. U.S.A. | 2002 | 12060727 | No |
| 2842 | 846 | 846.0 | 0.0 | 0.0 | A cytoarchitectonic atlas of the spinal cord in the cat. | B REXED | J. Comp. Neurol. | 1954 | 13163236 | Yes |
| 2843 | 2538 | 846.0 | 79.96 | 26.7 | Bacterial biofilms: from the natural environment to infectious diseases. | Luanne Hall-Stoodley, J William Costerton, Paul Stoodley | Nat. Rev. Microbiol. | 2004 | 15040259 | No |
| 2844 | 1692 | 846.0 | 45.96 | 23.0 | Cellular processing of platinum anticancer drugs. | Dong Wang, Stephen J Lippard | Nat Rev Drug Discov | 2005 | 15789122 | No |
| 2845 | 846 | 846.0 | 25.73 | 25.7 | Wound healing and its impairment in the diabetic foot. | Vincent Falanga | Lancet | 2005 | 16291068 | No |
| 2846 | 846 | 846.0 | 21.71 | 21.7 | The integration of macromolecular diffraction data. | Andrew G W Leslie | Acta Crystallogr. D Biol. Crystallogr. | 2006 | 16369093 | No |
| 2847 | 1692 | 846.0 | 60.05 | 30.0 | Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. | Xiaobo Chen, Samuel S Mao | Chem. Rev. | 2007 | 17590053 | Yes |
| 2848 | 1691 | 845.5 | 44.13 | 22.1 | Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. | G A Gonzalez, M R Montminy | Cell | 1989 | 2573431 | Yes |
| 2849 | 1691 | 845.5 | 36.87 | 18.4 | Rho GTPases and signaling networks. | L Van Aelst, C D'Souza-Schorey | Genes Dev. | 1997 | 9308960 | No |
| 2850 | 1690 | 845.0 | 47.37 | 23.7 | Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. | M E Feder, G E Hofmann | Annu. Rev. Physiol. | 1999 | 10099689 | No |
| 2851 | 845 | 845.0 | 30.45 | 30.4 | Cytokinesis-block micronucleus cytome assay. | Michael Fenech | Nat Protoc | 2007 | 17546000 | Yes |
| 2852 | 3379 | 844.8 | 100.84 | 25.2 | Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. | J E Walker, M Saraste, M J Runswick, N J Gay | EMBO J. | 1982 | 6329717 | Yes |
| 2853 | 6758 | 844.8 | 219.87 | 27.5 | A method and server for predicting damaging missense mutations. | Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R Sunyaev | Nat. Methods | 2010 | 20354512 | Yes |
| 2854 | 1689 | 844.5 | 0.0 | 0.0 | A method of trace iodination of proteins for immunologic studies. | P J McConahey, F J Dixon | Int. Arch. Allergy Appl. Immunol. | 1966 | 4160044 | Yes |
| 2855 | 844 | 844.0 | 25.46 | 25.5 | Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. | G Boden | Diabetes | 1997 | 8971073 | No |
| 2856 | 844 | 844.0 | 22.56 | 22.6 | Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. | H J Dargie | Lancet | 2001 | 11356434 | Yes |
| 2857 | 1688 | 844.0 | 32.67 | 16.3 | An extensive class of small RNAs in Caenorhabditis elegans. | R C Lee, V Ambros | Science | 2001 | 11679672 | Yes |
| 2858 | 844 | 844.0 | 0.0 | 0.0 | The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. | G A ROSE | Bull. World Health Organ. | 1962 | 13974778 | Yes |
| 2859 | 844 | 844.0 | 16.99 | 17.0 | TNF/TNFR family members in costimulation of T cell responses. | Tania H Watts | Annu. Rev. Immunol. | 2005 | 15771565 | No |
| 2860 | 843 | 843.0 | 32.66 | 32.7 | Signaling through phosphatidylcholine breakdown. | J H Exton | J. Biol. Chem. | 1990 | 2104616 | No |
| 2861 | 843 | 843.0 | 31.68 | 31.7 | Fibronectin and its receptors. | E Ruoslahti | Annu. Rev. Biochem. | 1988 | 2972252 | No |
| 2862 | 843 | 843.0 | 22.65 | 22.6 | The prefrontal cortex--an update: time is of the essence. | J M Fuster | Neuron | 2001 | 11394996 | No |
| 2863 | 842 | 842.0 | 0.0 | 0.0 | Fundamental patterns of knowing in nursing. | B Carper | ANS Adv Nurs Sci | 1978 | 110216 | Yes |
| 2864 | 2526 | 842.0 | 81.95 | 27.3 | Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). | R S Spielman, R E McGinnis, W J Ewens | Am. J. Hum. Genet. | 1993 | 8447318 | Yes |
| 2865 | 2526 | 842.0 | 60.24 | 20.1 | TGF-beta signalling from cell membrane to nucleus through SMAD proteins. | C H Heldin, K Miyazono, P ten Dijke | Nature | 1997 | 9393997 | No |
| 2866 | 1684 | 842.0 | 0.0 | 0.0 | The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. | B N AMES, D T DUBIN | J. Biol. Chem. | 1960 | 13793161 | Yes |
| 2867 | 841 | 841.0 | 42.89 | 42.9 | A spreading-activation theory of retrieval in sentence production. | G S Dell | Psychol Rev | 1986 | 3749399 | Yes |
| 2868 | 841 | 841.0 | 0.0 | 0.0 | The prevalence of 'alexithymic' characteristics in psychosomatic patients. | P E Sifneos | Psychother Psychosom | 1973 | 4770536 | Yes |
| 2869 | 841 | 841.0 | 56.01 | 56.0 | The clinical application of the biopsychosocial model. | G L Engel | Am J Psychiatry | 1980 | 7369396 | Yes |
| 2870 | 841 | 841.0 | 33.02 | 33.0 | Low-molecular-weight heparins. | J I Weitz | N. Engl. J. Med. | 1997 | 9278467 | No |
| 2871 | 1682 | 841.0 | 32.49 | 16.2 | Effective targeted gene 'knockdown' in zebrafish. | A Nasevicius, S C Ekker | Nat. Genet. | 2000 | 11017081 | Yes |
| 2872 | 841 | 841.0 | 23.72 | 23.7 | Context and behavioral processes in extinction. | Mark E Bouton | Learn. Mem. | 2004 | 15466298 | No |
| 2873 | 2521 | 840.3 | 78.55 | 26.2 | Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. | M K Parmar, V Torri, L Stewart | Stat Med | 1998 | 9921604 | Yes |
| 2874 | 3361 | 840.2 | 106.08 | 26.5 | Real time quantitative PCR. | C A Heid, J Stevens, K J Livak, P M Williams | Genome Res. | 1996 | 8908518 | Yes |
| 2875 | 1680 | 840.0 | 63.03 | 31.5 | A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR. | V L Miller, J J Mekalanos | J. Bacteriol. | 1988 | 2836362 | Yes |
| 2876 | 840 | 840.0 | 21.64 | 21.6 | At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. | M Kozak | J. Mol. Biol. | 1987 | 3681984 | Yes |
| 2877 | 840 | 840.0 | 28.15 | 28.1 | The effects of stressful life events on depression. | R C Kessler | Annu Rev Psychol | 1997 | 9046559 | No |
| 2878 | 840 | 840.0 | 26.78 | 26.8 | The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. | R A Jain | Biomaterials | 2000 | 11055295 | No |
| 2879 | 840 | 840.0 | 29.62 | 29.6 | Insecticide-treated bed nets and curtains for preventing malaria. | C Lengeler | Cochrane Database Syst Rev | 2004 | 15106149 | No |
| 2880 | 840 | 840.0 | 29.76 | 29.8 | Cholinesterase inhibitors for Alzheimer's disease. | J Birks | Cochrane Database Syst Rev | 2006 | 16437532 | No |
| 2881 | 840 | 840.0 | 19.14 | 19.1 | The evolutionary significance of cis-regulatory mutations. | Gregory A Wray | Nat. Rev. Genet. | 2007 | 17304246 | No |
| 2882 | 839 | 839.0 | 41.87 | 41.9 | Infection by verocytotoxin-producing Escherichia coli. | M A Karmali | Clin. Microbiol. Rev. | 1989 | 2644022 | No |
| 2883 | 839 | 839.0 | 23.38 | 23.4 | Amyloid, the presenilins and Alzheimer's disease. | J Hardy | Trends Neurosci. | 1997 | 9106355 | No |
| 2884 | 839 | 839.0 | 21.17 | 21.2 | Dendritic cells: unique leukocyte populations which control the primary immune response. | D N Hart | Blood | 1997 | 9345009 | No |
| 2885 | 839 | 839.0 | 23.48 | 23.5 | Differential projections of the infralimbic and prelimbic cortex in the rat. | Robert P Vertes | Synapse | 2004 | 14579424 | Yes |
| 2886 | 1678 | 839.0 | 59.39 | 29.7 | Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. | Taro Kawai, Shizuo Akira | Immunity | 2011 | 21616434 | No |
| 2887 | 1677 | 838.5 | 58.71 | 29.4 | The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. | W L Jorgensen, J Tirado-Rives | J. Am. Chem. Soc. | 1988 | 27557051 | Yes |
| 2888 | 838 | 838.0 | 28.62 | 28.6 | The fetal and infant origins of adult disease. | D J Barker | BMJ | 1990 | 2252919 | No |
| 2889 | 1676 | 838.0 | 61.88 | 30.9 | Compilation and analysis of Escherichia coli promoter DNA sequences. | D K Hawley, W R McClure | Nucleic Acids Res. | 1983 | 6344016 | No |
| 2890 | 838 | 838.0 | 27.11 | 27.1 | Molecular drive: a cohesive mode of species evolution. | G Dover | Nature | 1982 | 7110332 | Yes |
| 2891 | 838 | 838.0 | 21.71 | 21.7 | The state of lipid rafts: from model membranes to cells. | Michael Edidin | Annu Rev Biophys Biomol Struct | 2003 | 12543707 | No |
| 2892 | 1676 | 838.0 | 84.74 | 42.4 | Van der Waals heterostructures. | A K Geim, I V Grigorieva | Nature | 2013 | 23887427 | Yes |
| 2893 | 7540 | 837.8 | 318.84 | 35.4 | STAR: ultrafast universal RNA-seq aligner. | Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R Gingeras | Bioinformatics | 2013 | 23104886 | Yes |
| 2894 | 2513 | 837.7 | 80.5 | 26.8 | Methods in mammalian autophagy research. | Noboru Mizushima, Tamotsu Yoshimori, Beth Levine | Cell | 2010 | 20144757 | Yes |
| 2895 | 1675 | 837.5 | 0.0 | 0.0 | Solubilization of membranes by detergents. | A Helenius, K Simons | Biochim. Biophys. Acta | 1975 | 1091302 | No |
| 2896 | 1675 | 837.5 | 42.98 | 21.5 | Regulation of translation initiation in eukaryotes: mechanisms and biological targets. | Nahum Sonenberg, Alan G Hinnebusch | Cell | 2009 | 19239892 | No |
| 2897 | 837 | 837.0 | 21.63 | 21.6 | Molecular mechanisms of myocardial remodeling. | B Swynghedauw | Physiol. Rev. | 1999 | 9922372 | No |
| 2898 | 837 | 837.0 | 15.12 | 15.1 | SCF and Cullin/Ring H2-based ubiquitin ligases. | R J Deshaies | Annu. Rev. Cell Dev. Biol. | 1999 | 10611969 | No |
| 2899 | 837 | 837.0 | 21.43 | 21.4 | Epstein-Barr virus infection. | J I Cohen | N. Engl. J. Med. | 2000 | 10944566 | No |
| 2900 | 836 | 836.0 | 28.85 | 28.9 | Comparing evolvability and variability of quantitative traits. | D Houle | Genetics | 1992 | 1732160 | Yes |
| 2901 | 836 | 836.0 | 113.99 | 114.0 | The analysis of errors in orthodontic measurements. | W J Houston | Am J Orthod | 1983 | 6573846 | Yes |
| 2902 | 836 | 836.0 | 48.06 | 48.1 | Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. | E H Beachey | J. Infect. Dis. | 1981 | 7014727 | No |
| 2903 | 836 | 836.0 | 48.71 | 48.7 | Toward terminological, conceptual, and statistical clarity in the study of mediators and moderators: examples from the child-clinical and pediatric psychology literatures. | G N Holmbeck | J Consult Clin Psychol | 1997 | 9256561 | Yes |
| 2904 | 836 | 836.0 | 28.44 | 28.4 | Venous thrombosis: a multicausal disease. | F R Rosendaal | Lancet | 1999 | 10209995 | No |
| 2905 | 836 | 836.0 | 31.38 | 31.4 | MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. | Amy E Pasquinelli | Nat. Rev. Genet. | 2012 | 22411466 | No |
| 2906 | 1671 | 835.5 | 40.12 | 20.1 | InterProScan--an integration platform for the signature-recognition methods in InterPro. | E M Zdobnov, R Apweiler | Bioinformatics | 2001 | 11590104 | Yes |
| 2907 | 9187 | 835.2 | 379.84 | 34.5 | A new equation to estimate glomerular filtration rate. | Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef Coresh | Ann. Intern. Med. | 2009 | 19414839 | Yes |
| 2908 | 1670 | 835.0 | 0.0 | 0.0 | Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. | J D McGhee, P H von Hippel | J. Mol. Biol. | 1974 | 4416620 | Yes |
| 2909 | 835 | 835.0 | 36.29 | 36.3 | Socioeconomic disadvantage and child development. | V C McLoyd | Am Psychol | 1998 | 9491747 | No |
| 2910 | 834 | 834.0 | 0.0 | 0.0 | Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. | W W Douglas | Br. J. Pharmacol. | 1968 | 4882190 | No |
| 2911 | 834 | 834.0 | 0.0 | 0.0 | 6-Hydroxy-dopamine induced degeneration of central monoamine neurons. | U Ungerstedt | Eur. J. Pharmacol. | 1968 | 5718510 | Yes |
| 2912 | 834 | 834.0 | 22.74 | 22.7 | Seed Germination and Dormancy. | J. D. Bewley | Plant Cell | 1997 | 12237375 | Yes |
| 2913 | 5002 | 833.7 | 154.19 | 25.7 | Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. | S Yusuf, P Sleight, J Pogue, J Bosch, R Davies, G Dagenais | N. Engl. J. Med. | 2000 | 10639539 | Yes |
| 2914 | 5001 | 833.5 | 182.33 | 30.4 | Free radicals and antioxidants in normal physiological functions and human disease. | Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua Telser | Int. J. Biochem. Cell Biol. | 2007 | 16978905 | No |
| 2915 | 833 | 833.0 | 21.52 | 21.5 | Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. | R H Schwartz | Cell | 1992 | 1335362 | No |
| 2916 | 833 | 833.0 | 22.85 | 22.9 | Atherosclerosis is an inflammatory disease. | R Ross | Am. Heart J. | 1999 | 10539839 | No |
| 2917 | 1666 | 833.0 | 35.89 | 17.9 | AP-1 as a regulator of cell life and death. | Eitan Shaulian, Michael Karin | Nat. Cell Biol. | 2002 | 11988758 | No |
| 2918 | 833 | 833.0 | 21.51 | 21.5 | r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock. | Michael J Sanderson | Bioinformatics | 2003 | 12538260 | Yes |
| 2919 | 833 | 833.0 | 0.0 | 0.0 | A modified procedure for lead staining of thin sections. | G MILLONIG | J Biophys Biochem Cytol | 1961 | 14474176 | Yes |
| 2920 | 833 | 833.0 | 17.0 | 17.0 | Dendritic-cell control of pathogen-driven T-cell polarization. | Martien L Kapsenberg | Nat. Rev. Immunol. | 2003 | 14647480 | No |
| 2921 | 1666 | 833.0 | 52.03 | 26.0 | Recent developments in the MAFFT multiple sequence alignment program. | Kazutaka Katoh, Hiroyuki Toh | Brief. Bioinformatics | 2008 | 18372315 | Yes |
| 2922 | 1665 | 832.5 | 50.92 | 25.5 | ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. | Markus Wiederstein, Manfred J Sippl | Nucleic Acids Res. | 2007 | 17517781 | Yes |
| 2923 | 4993 | 832.2 | 152.49 | 25.4 | The capsaicin receptor: a heat-activated ion channel in the pain pathway. | M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D Julius | Nature | 1997 | 9349813 | Yes |
| 2924 | 832 | 832.0 | 33.87 | 33.9 | Computer programs for calculating total from specified free or free from specified total ionic concentrations in aqueous solutions containing multiple metals and ligands. | A Fabiato | Meth. Enzymol. | 1988 | 3231093 | Yes |
| 2925 | 1664 | 832.0 | 39.09 | 19.5 | IAP family proteins--suppressors of apoptosis. | Q L Deveraux, J C Reed | Genes Dev. | 1999 | 9990849 | No |
| 2926 | 832 | 832.0 | 17.08 | 17.1 | MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. | Victor Ambros | Cell | 2003 | 12809598 | No |
| 2927 | 832 | 832.0 | 16.93 | 16.9 | NFAT proteins: key regulators of T-cell development and function. | Fernando Macian | Nat. Rev. Immunol. | 2005 | 15928679 | No |
| 2928 | 832 | 832.0 | 24.01 | 24.0 | Tumour necrosis factor and cancer. | Frances Balkwill | Nat. Rev. Cancer | 2009 | 19343034 | No |
| 2929 | 1663 | 831.5 | 80.57 | 40.3 | Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. | A I Basbaum, H L Fields | Annu. Rev. Neurosci. | 1984 | 6143527 | No |
| 2930 | 2494 | 831.3 | 118.09 | 39.4 | Neighborhoods and violent crime: a multilevel study of collective efficacy. | R J Sampson, S W Raudenbush, F Earls | Science | 1997 | 9252316 | Yes |
| 2931 | 2494 | 831.3 | 104.56 | 34.9 | Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. | B K Matuszewski, M L Constanzer, C M Chavez-Eng | Anal. Chem. | 2003 | 12964746 | Yes |
| 2932 | 831 | 831.0 | 34.92 | 34.9 | Protein damage and degradation by oxygen radicals. I. general aspects. | K J Davies | J. Biol. Chem. | 1987 | 3036875 | Yes |
| 2933 | 1662 | 831.0 | 0.0 | 0.0 | The hitch-hiking effect of a favourable gene. | J M Smith, J Haigh | Genet. Res. | 1974 | 4407212 | Yes |
| 2934 | 831 | 831.0 | 20.57 | 20.6 | Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. | H E Ruley | Nature | 1983 | 6308473 | Yes |
| 2935 | 2493 | 831.0 | 85.18 | 28.4 | A sensitive and reliable locomotor rating scale for open field testing in rats. | D M Basso, M S Beattie, J C Bresnahan | J. Neurotrauma | 1995 | 7783230 | Yes |
| 2936 | 831 | 831.0 | 24.37 | 24.4 | PHOTOPROTECTION REVISITED: Genetic and Molecular Approaches. | Krishna K. Niyogi | Annu. Rev. Plant Physiol. Plant Mol. Biol. | 1999 | 15012213 | Yes |
| 2937 | 4154 | 830.8 | 86.42 | 17.3 | The protein kinase complement of the human genome. | G Manning, D B Whyte, R Martinez, T Hunter, S Sudarsanam | Science | 2002 | 12471243 | No |
| 2938 | 3322 | 830.5 | 95.0 | 23.8 | Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. | L M Guzman, D Belin, M J Carson, J Beckwith | J. Bacteriol. | 1995 | 7608087 | Yes |
| 2939 | 830 | 830.0 | 19.78 | 19.8 | Cytokine receptor signalling. | J N Ihle | Nature | 1995 | 7566171 | No |
| 2940 | 1660 | 830.0 | 43.48 | 21.7 | Obesity and insulin resistance. | B B Kahn, J S Flier | J. Clin. Invest. | 2000 | 10953022 | No |
| 2941 | 830 | 830.0 | 15.7 | 15.7 | Roles of the NKG2D immunoreceptor and its ligands. | David H Raulet | Nat. Rev. Immunol. | 2003 | 14523385 | No |
| 2942 | 830 | 830.0 | 28.23 | 28.2 | A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. | Ron Hardman | Environ. Health Perspect. | 2006 | 16451849 | No |
| 2943 | 830 | 830.0 | 50.46 | 50.5 | Statistics corner: A guide to appropriate use of correlation coefficient in medical research. | M M Mukaka | Malawi Med J | 2012 | 23638278 | Yes |
| 2944 | 829 | 829.0 | 0.0 | 0.0 | Renin-angiotensin system: biochemistry and mechanisms of action. | M J Peach | Physiol. Rev. | 1977 | 191856 | No |
| 2945 | 829 | 829.0 | 19.26 | 19.3 | Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. | D Hanahan | Nature | 1985 | 2986015 | Yes |
| 2946 | 1658 | 829.0 | 37.62 | 18.8 | A survey of telomerase activity in human cancer. | J W Shay, S Bacchetti | Eur. J. Cancer | 1997 | 9282118 | No |
| 2947 | 829 | 829.0 | 18.97 | 19.0 | The Sp-family of transcription factors. | G Suske | Gene | 1999 | 10570957 | No |
| 2948 | 829 | 829.0 | 18.71 | 18.7 | VEGF and the quest for tumour angiogenesis factors. | Napoleone Ferrara | Nat. Rev. Cancer | 2002 | 12360282 | No |
| 2949 | 2485 | 828.3 | 63.69 | 21.2 | Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. | Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen | Science | 2005 | 15831717 | Yes |
| 2950 | 828 | 828.0 | 31.34 | 31.3 | Cytochrome oxidase: an endogenous metabolic marker for neuronal activity. | M T Wong-Riley | Trends Neurosci. | 1989 | 2469224 | No |
| 2951 | 828 | 828.0 | 24.88 | 24.9 | Cells in stress: transcriptional activation of heat shock genes. | R I Morimoto | Science | 1993 | 8451637 | No |
| 2952 | 828 | 828.0 | 24.22 | 24.2 | Transcriptional paradigms in mammalian mitochondrial biogenesis and function. | Richard C Scarpulla | Physiol. Rev. | 2008 | 18391175 | No |
| 2953 | 828 | 828.0 | 49.75 | 49.8 | The emerging role of lncRNAs in cancer. | Maite Huarte | Nat. Med. | 2015 | 26540387 | No |
| 2954 | 1655 | 827.5 | 42.9 | 21.4 | Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. | N Sreerama, R W Woody | Anal. Biochem. | 2000 | 11112271 | Yes |
| 2955 | 827 | 827.0 | 38.65 | 38.6 | Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. | J N Wasserheit | Sex Transm Dis | 1992 | 1595015 | No |
| 2956 | 1654 | 827.0 | 41.72 | 20.9 | Multiple nuclear factors interact with the immunoglobulin enhancer sequences. | R Sen, D Baltimore | Cell | 1986 | 3091258 | Yes |
| 2957 | 1654 | 827.0 | 0.0 | 0.0 | Calcium-dependent bacteriophage DNA infection. | M Mandel, A Higa | J. Mol. Biol. | 1970 | 4922220 | Yes |
| 2958 | 827 | 827.0 | 27.26 | 27.3 | Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. | Michael F Holick | Am. J. Clin. Nutr. | 2004 | 14985208 | No |
| 2959 | 2481 | 827.0 | 59.09 | 19.7 | Adjusting batch effects in microarray expression data using empirical Bayes methods. | W Evan Johnson, Cheng Li, Ariel Rabinovic | Biostatistics | 2007 | 16632515 | Yes |
| 2960 | 1653 | 826.5 | 41.15 | 20.6 | Roles of CHOP/GADD153 in endoplasmic reticulum stress. | S Oyadomari, M Mori | Cell Death Differ. | 2004 | 14685163 | No |
| 2961 | 3305 | 826.2 | 87.17 | 21.8 | Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. | E Schreiber, P Matthias, M M Müller, W Schaffner | Nucleic Acids Res. | 1989 | 2771659 | Yes |
| 2962 | 1652 | 826.0 | 0.0 | 0.0 | Peptidoglycan types of bacterial cell walls and their taxonomic implications. | K H Schleifer, O Kandler | Bacteriol Rev | 1972 | 4568761 | No |
| 2963 | 1652 | 826.0 | 75.89 | 37.9 | Excitatory amino acid transmitters. | J C Watkins, R H Evans | Annu. Rev. Pharmacol. Toxicol. | 1981 | 6112965 | No |
| 2964 | 826 | 826.0 | 24.28 | 24.3 | Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system. | T Ikemura | J. Mol. Biol. | 1981 | 6175758 | Yes |
| 2965 | 826 | 826.0 | 0.0 | 0.0 | Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. | G D WINTER | Nature | 1962 | 14007593 | Yes |
| 2966 | 826 | 826.0 | 36.21 | 36.2 | AmpC beta-lactamases. | George A Jacoby | Clin. Microbiol. Rev. | 2009 | 19136439 | No |
| 2967 | 1651 | 825.5 | 41.6 | 20.8 | microRNA functions. | Natascha Bushati, Stephen M Cohen | Annu. Rev. Cell Dev. Biol. | 2007 | 17506695 | No |
| 2968 | 1650 | 825.0 | 0.0 | 0.0 | Epidermal growth factor. | G Carpenter, S Cohen | Annu. Rev. Biochem. | 1979 | 382984 | No |
| 2969 | 825 | 825.0 | 26.72 | 26.7 | The sphingomyelin cycle and the second messenger function of ceramide. | Y A Hannun | J. Biol. Chem. | 1994 | 8106344 | No |
| 2970 | 825 | 825.0 | 28.04 | 28.0 | Synchronization of cortical activity and its putative role in information processing and learning. | W Singer | Annu. Rev. Physiol. | 1993 | 8466179 | No |
| 2971 | 825 | 825.0 | 24.68 | 24.7 | Neuropathology of Parkinson's disease. | L S Forno | J. Neuropathol. Exp. Neurol. | 1996 | 8786384 | No |
| 2972 | 825 | 825.0 | 30.64 | 30.6 | Stronger Brønsted acids. | Takahiko Akiyama | Chem. Rev. | 2007 | 17983247 | Yes |
| 2973 | 825 | 825.0 | 0.0 | 0.0 | A simple objective technique for measuring flexibility in thinking. | E A BERG | J Gen Psychol | 1948 | 18889466 | Yes |
| 2974 | 1649 | 824.5 | 45.43 | 22.7 | RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. | M B Shapiro, P Senapathy | Nucleic Acids Res. | 1987 | 3658675 | Yes |
| 2975 | 2473 | 824.3 | 94.82 | 31.6 | SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building. | Manolo Gouy, Stéphane Guindon, Olivier Gascuel | Mol. Biol. Evol. | 2010 | 19854763 | Yes |
| 2976 | 824 | 824.0 | 0.0 | 0.0 | Letter: Grading of angina pectoris. | L Campeau | Circulation | 1976 | 947585 | Yes |
| 2977 | 824 | 824.0 | 67.59 | 67.6 | A method of analysing interview transcripts in qualitative research. | P Burnard | Nurse Educ Today | 1991 | 1775125 | Yes |
| 2978 | 2472 | 824.0 | 112.32 | 37.4 | Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. | P S Walsh, D A Metzger, R Higuchi | BioTechniques | 1991 | 1867860 | Yes |
| 2979 | 824 | 824.0 | 34.99 | 35.0 | Post-hoc probing of significant moderational and mediational effects in studies of pediatric populations. | Grayson N Holmbeck | J Pediatr Psychol | 2002 | 11726683 | No |
| 2980 | 1646 | 823.0 | 0.0 | 0.0 | Growth of a rat neuroblastoma cell line in serum-free supplemented medium. | J E Bottenstein, G H Sato | Proc. Natl. Acad. Sci. U.S.A. | 1979 | 284369 | Yes |
| 2981 | 823 | 823.0 | 23.22 | 23.2 | Cadherins: a molecular family important in selective cell-cell adhesion. | M Takeichi | Annu. Rev. Biochem. | 1990 | 2197976 | No |
| 2982 | 823 | 823.0 | 21.55 | 21.6 | Translating cell biology into therapeutic advances in Alzheimer's disease. | D J Selkoe | Nature | 1999 | 10392577 | No |
| 2983 | 823 | 823.0 | 29.68 | 29.7 | The role of rumination in depressive disorders and mixed anxiety/depressive symptoms. | S Nolen-Hoeksema | J Abnorm Psychol | 2000 | 11016119 | Yes |
| 2984 | 823 | 823.0 | 26.9 | 26.9 | Epidemiology of women and depression. | Ronald C Kessler | J Affect Disord | 2003 | 12646294 | Yes |
| 2985 | 1646 | 823.0 | 58.5 | 29.2 | The spread of obesity in a large social network over 32 years. | Nicholas A Christakis, James H Fowler | N. Engl. J. Med. | 2007 | 17652652 | Yes |
| 2986 | 1645 | 822.5 | 0.0 | 0.0 | Functions of lysosomes. | C De Duve, R Wattiaux | Annu. Rev. Physiol. | 1966 | 5322983 | No |
| 2987 | 4111 | 822.2 | 0.0 | 0.0 | Enzymatic determination of total serum cholesterol. | C C Allain, L S Poon, C S Chan, W Richmond, P C Fu | Clin. Chem. | 1974 | 4818200 | Yes |
| 2988 | 822 | 822.0 | 52.33 | 52.3 | Continuous improvement as an ideal in health care. | D M Berwick | N. Engl. J. Med. | 1989 | 2909878 | Yes |
| 2989 | 822 | 822.0 | 53.6 | 53.6 | Analysis of Fickian and non-Fickian drug release from polymers. | N A Peppas | Pharm Acta Helv | 1985 | 4011621 | Yes |
| 2990 | 822 | 822.0 | 24.18 | 24.2 | Nidovirales: a new order comprising Coronaviridae and Arteriviridae. | D Cavanagh | Arch. Virol. | 1997 | 9349308 | Yes |
| 2991 | 822 | 822.0 | 24.6 | 24.6 | Automatic quantitation of localized in vivo 1H spectra with LCModel. | S W Provencher | NMR Biomed | 2001 | 11410943 | Yes |
| 2992 | 822 | 822.0 | 14.96 | 15.0 | T cell anergy. | Ronald H Schwartz | Annu. Rev. Immunol. | 2003 | 12471050 | No |
| 2993 | 822 | 822.0 | 25.84 | 25.8 | Functionalized acenes and heteroacenes for organic electronics. | John E Anthony | Chem. Rev. | 2006 | 17165682 | Yes |
| 2994 | 1643 | 821.5 | 71.87 | 35.9 | Glutamate and the pathophysiology of hypoxic--ischemic brain damage. | S M Rothman, J W Olney | Ann. Neurol. | 1986 | 2421636 | No |
| 2995 | 1643 | 821.5 | 40.42 | 20.2 | p53: puzzle and paradigm. | L J Ko, C Prives | Genes Dev. | 1996 | 8654922 | No |
| 2996 | 821 | 821.0 | 0.0 | 0.0 | Evaluation of a mental test score for assessment of mental impairment in the elderly. | H M Hodkinson | Age Ageing | 1972 | 4669880 | Yes |
| 2997 | 821 | 821.0 | 0.0 | 0.0 | Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units. | C M Venkatachalam | Biopolymers | 1968 | 5685102 | Yes |
| 2998 | 821 | 821.0 | 57.85 | 57.9 | New norms of upper limb fat and muscle areas for assessment of nutritional status. | A R Frisancho | Am. J. Clin. Nutr. | 1981 | 6975564 | Yes |
| 2999 | 821 | 821.0 | 23.45 | 23.4 | Comparative physiology of salt and water stress. | R. Munns | Plant Cell Environ. | 2002 | 11841667 | Yes |
| 3000 | 821 | 821.0 | 0.0 | 0.0 | PRELIMINARY TRIAL OF CARISOPRODOL IN MULTIPLE SCLEROSIS. | B ASHWORTH | Practitioner | 1964 | 14143329 | Yes |
| 3001 | 821 | 821.0 | 19.48 | 19.5 | Fibrotic disease and the T(H)1/T(H)2 paradigm. | Thomas A Wynn | Nat. Rev. Immunol. | 2004 | 15286725 | No |
| 3002 | 820 | 820.0 | 25.07 | 25.1 | Apoptosis in cancer therapy: crossing the threshold. | D E Fisher | Cell | 1994 | 8069905 | No |
| 3003 | 4920 | 820.0 | 154.58 | 25.8 | Ghrelin is a growth-hormone-releasing acylated peptide from stomach. | M Kojima, H Hosoda, Y Date, M Nakazato, H Matsuo, K Kangawa | Nature | 1999 | 10604470 | Yes |
| 3004 | 1640 | 820.0 | 63.8 | 31.9 | Inflammatory mechanisms in obesity. | Margaret F Gregor, Gökhan S Hotamisligil | Annu. Rev. Immunol. | 2011 | 21219177 | No |
| 3005 | 819 | 819.0 | 33.75 | 33.8 | Cholesterol and the cell membrane. | P L Yeagle | Biochim. Biophys. Acta | 1985 | 3904832 | No |
| 3006 | 819 | 819.0 | 18.59 | 18.6 | [URE3] as an altered URE2 protein: evidence for a prion analog in Saccharomyces cerevisiae. | R B Wickner | Science | 1994 | 7909170 | No |
| 3007 | 819 | 819.0 | 35.11 | 35.1 | Why we need observational studies to evaluate the effectiveness of health care. | N Black | BMJ | 1996 | 8634569 | Yes |
| 3008 | 819 | 819.0 | 28.58 | 28.6 | Riddle of biofilm resistance. | K Lewis | Antimicrob. Agents Chemother. | 2001 | 11257008 | No |
| 3009 | 819 | 819.0 | 17.46 | 17.5 | The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. | Y Yarden | Eur. J. Cancer | 2001 | 11597398 | No |
| 3010 | 819 | 819.0 | 17.0 | 17.0 | DNA methylation in cancer: too much, but also too little. | Melanie Ehrlich | Oncogene | 2002 | 12154403 | No |
| 3011 | 1638 | 819.0 | 36.82 | 18.4 | Convergence of Wnt, beta-catenin, and cadherin pathways. | W James Nelson, Roel Nusse | Science | 2004 | 15001769 | No |
| 3012 | 819 | 819.0 | 24.69 | 24.7 | Dengue. | Scott B Halstead | Lancet | 2007 | 17993365 | No |
| 3013 | 1637 | 818.5 | 0.0 | 0.0 | A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. | B G Durie, S E Salmon | Cancer | 1975 | 1182674 | Yes |
| 3014 | 2454 | 818.0 | 56.69 | 18.9 | Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. | E Li, T H Bestor, R Jaenisch | Cell | 1992 | 1606615 | Yes |
| 3015 | 818 | 818.0 | 0.0 | 0.0 | The relation of the trail making test to organic brain damage. | R M REITAN | J Consult Psychol | 1955 | 13263471 | Yes |
| 3016 | 818 | 818.0 | 43.34 | 43.3 | What is self-rated health and why does it predict mortality? Towards a unified conceptual model. | Marja Jylhä | Soc Sci Med | 2009 | 19520474 | Yes |
| 3017 | 1635 | 817.5 | 86.99 | 43.5 | Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. | L A Clark, D Watson | J Abnorm Psychol | 1991 | 1918611 | No |
| 3018 | 817 | 817.0 | 0.0 | 0.0 | Human cardiovascular adjustments to exercise and thermal stress. | L B Rowell | Physiol. Rev. | 1974 | 4587247 | No |
| 3019 | 817 | 817.0 | 0.0 | 0.0 | Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities. | F Fonnum | Biochem. J. | 1969 | 4982085 | Yes |
| 3020 | 817 | 817.0 | 0.0 | 0.0 | Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. | J R David | Proc. Natl. Acad. Sci. U.S.A. | 1966 | 5229858 | Yes |
| 3021 | 817 | 817.0 | 17.54 | 17.5 | Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast. | L Guarente | Meth. Enzymol. | 1983 | 6310321 | Yes |
| 3022 | 1634 | 817.0 | 43.15 | 21.6 | PedCheck: a program for identification of genotype incompatibilities in linkage analysis. | J R O'Connell, D E Weeks | Am. J. Hum. Genet. | 1998 | 9634505 | Yes |
| 3023 | 1634 | 817.0 | 38.52 | 19.3 | Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin. | J J Skehel, D C Wiley | Annu. Rev. Biochem. | 2000 | 10966468 | No |
| 3024 | 817 | 817.0 | 28.28 | 28.3 | Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. | P Vestergaard | Osteoporos Int | 2007 | 17068657 | No |
| 3025 | 817 | 817.0 | 30.69 | 30.7 | Deconvoluting the context-dependent role for autophagy in cancer. | Eileen White | Nat. Rev. Cancer | 2012 | 22534666 | No |
| 3026 | 817 | 817.0 | 56.69 | 56.7 | Gctf: Real-time CTF determination and correction. | Kai Zhang | J. Struct. Biol. | 2016 | 26592709 | Yes |
| 3027 | 1631 | 815.5 | 0.0 | 0.0 | Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. | G K McMaster, G G Carmichael | Proc. Natl. Acad. Sci. U.S.A. | 1977 | 73185 | Yes |
| 3028 | 1630 | 815.0 | 72.3 | 36.1 | Social conditions as fundamental causes of disease. | B G Link, J Phelan | J Health Soc Behav | 1995 | 7560851 | No |
| 3029 | 815 | 815.0 | 28.06 | 28.1 | Apoptosis. | J J Cohen | Immunol. Today | 1993 | 8466628 | No |
| 3030 | 1630 | 815.0 | 41.74 | 20.9 | Principles of protein-protein interactions. | S Jones, J M Thornton | Proc. Natl. Acad. Sci. U.S.A. | 1996 | 8552589 | No |
| 3031 | 1629 | 814.5 | 41.63 | 20.8 | Deep tissue two-photon microscopy. | Fritjof Helmchen, Winfried Denk | Nat. Methods | 2005 | 16299478 | No |
| 3032 | 814 | 814.0 | 40.76 | 40.8 | Geriatric Depression Scale. | J A Yesavage | Psychopharmacol Bull | 1988 | 3249773 | Yes |
| 3033 | 814 | 814.0 | 30.44 | 30.4 | Muscarinic receptors--characterization, coupling and function. | M P Caulfield | Pharmacol. Ther. | 1993 | 7504306 | No |
| 3034 | 814 | 814.0 | 23.62 | 23.6 | Nitric oxide, oxidants, and protein tyrosine nitration. | Rafael Radi | Proc. Natl. Acad. Sci. U.S.A. | 2004 | 15020765 | Yes |
| 3035 | 813 | 813.0 | 44.83 | 44.8 | Error in medicine. | L L Leape | JAMA | 1994 | 7503827 | Yes |
| 3036 | 813 | 813.0 | 20.11 | 20.1 | Prediction of protein cellular attributes using pseudo-amino acid composition. | K C Chou | Proteins | 2001 | 11288174 | Yes |
| 3037 | 2439 | 813.0 | 54.01 | 18.0 | Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. | Paola Scaffidi, Tom Misteli, Marco E Bianchi | Nature | 2002 | 12110890 | Yes |
| 3038 | 1626 | 813.0 | 79.58 | 39.8 | Neutrophil recruitment and function in health and inflammation. | Elzbieta Kolaczkowska, Paul Kubes | Nat. Rev. Immunol. | 2013 | 23435331 | No |
| 3039 | 812 | 812.0 | 0.0 | 0.0 | A teacher rating scale for use in drug studies with children. | C K Conners | Am J Psychiatry | 1969 | 4900822 | Yes |
| 3040 | 812 | 812.0 | 27.18 | 27.2 | Endothelial-leukocyte adhesion molecules. | M P Bevilacqua | Annu. Rev. Immunol. | 1993 | 8476577 | No |
| 3041 | 1624 | 812.0 | 35.36 | 17.7 | The druggable genome. | Andrew L Hopkins, Colin R Groom | Nat Rev Drug Discov | 2002 | 12209152 | No |
| 3042 | 812 | 812.0 | 0.0 | 0.0 | Agammaglobulinemia. | O C BRUTON | Pediatrics | 1952 | 14929630 | Yes |
| 3043 | 812 | 812.0 | 21.64 | 21.6 | Oxygen, oxidative stress, hypoxia, and heart failure. | Frank J Giordano | J. Clin. Invest. | 2005 | 15765131 | No |
| 3044 | 1623 | 811.5 | 0.0 | 0.0 | Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. | R B Gustilo, J T Anderson | J Bone Joint Surg Am | 1976 | 773941 | Yes |
| 3045 | 4869 | 811.5 | 156.2 | 26.0 | Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. | D A Melton, P A Krieg, M R Rebagliati, T Maniatis, K Zinn, M R Green | Nucleic Acids Res. | 1984 | 6091052 | Yes |
| 3046 | 1623 | 811.5 | 51.4 | 25.7 | Hydrogels for tissue engineering: scaffold design variables and applications. | Jeanie L Drury, David J Mooney | Biomaterials | 2003 | 12922147 | No |
| 3047 | 811 | 811.0 | 0.0 | 0.0 | Evolution of ageing. | T B Kirkwood | Nature | 1977 | 593350 | Yes |
| 3048 | 1622 | 811.0 | 82.38 | 41.2 | Fingerprinting genomes using PCR with arbitrary primers. | J Welsh, M McClelland | Nucleic Acids Res. | 1990 | 2259619 | Yes |
| 3049 | 811 | 811.0 | 44.76 | 44.8 | The molecular biology of cytochrome P450s. | F J Gonzalez | Pharmacol. Rev. | 1988 | 3072575 | No |
| 3050 | 811 | 811.0 | 0.0 | 0.0 | The moulding of senescence by natural selection. | W D Hamilton | J. Theor. Biol. | 1966 | 6015424 | Yes |
| 3051 | 811 | 811.0 | 16.7 | 16.7 | Thiamine-repressible expression vectors pREP and pRIP for fission yeast. | K Maundrell | Gene | 1993 | 8422996 | Yes |
| 3052 | 811 | 811.0 | 23.73 | 23.7 | The orbitofrontal cortex and reward. | E T Rolls | Cereb. Cortex | 2000 | 10731223 | No |
| 3053 | 811 | 811.0 | 17.26 | 17.3 | The Pezcoller lecture: cancer cell cycles revisited. | C J Sherr | Cancer Res. | 2000 | 10919634 | No |
| 3054 | 811 | 811.0 | 0.0 | 0.0 | ELECTRON MICROSCOPE STUDIES ON THE STRUCTURE OF NATURAL AND SYNTHETIC PROTEIN FILAMENTS FROM STRIATED MUSCLE. | H E HUXLEY | J. Mol. Biol. | 1963 | 14064165 | Yes |
| 3055 | 811 | 811.0 | 0.0 | 0.0 | The cytoarchitectonic organization of the spinal cord in the cat. | B REXED | J. Comp. Neurol. | 1952 | 14946260 | Yes |
| 3056 | 811 | 811.0 | 0.0 | 0.0 | The colorimetric determination of phosphorus. | E J King | Biochem. J. | 1932 | 16744823 | Yes |
| 3057 | 1621 | 810.5 | 44.49 | 22.2 | Inflammation, stress, and diabetes. | Kathryn E Wellen, Gökhan S Hotamisligil | J. Clin. Invest. | 2005 | 15864338 | No |
| 3058 | 810 | 810.0 | 51.53 | 51.5 | Psychosocial models of the role of social support in the etiology of physical disease. | S Cohen | Health Psychol | 1988 | 3289916 | No |
| 3059 | 810 | 810.0 | 52.33 | 52.3 | Coping theory and research: past, present, and future. | R S Lazarus | Psychosom Med | 1993 | 8346332 | No |
| 3060 | 810 | 810.0 | 22.65 | 22.6 | Tensegrity: the architectural basis of cellular mechanotransduction. | D E Ingber | Annu. Rev. Physiol. | 1997 | 9074778 | No |
| 3061 | 810 | 810.0 | 15.75 | 15.8 | Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. | R A Frye | Biochem. Biophys. Res. Commun. | 2000 | 10873683 | Yes |
| 3062 | 810 | 810.0 | 21.11 | 21.1 | A cortical-hippocampal system for declarative memory. | H Eichenbaum | Nat. Rev. Neurosci. | 2000 | 11252767 | No |
| 3063 | 1620 | 810.0 | 35.9 | 17.9 | AMPA receptor trafficking and synaptic plasticity. | Roberto Malinow, Robert C Malenka | Annu. Rev. Neurosci. | 2002 | 12052905 | No |
| 3064 | 810 | 810.0 | 0.0 | 0.0 | Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. | P C NOWELL | Cancer Res. | 1960 | 14427849 | Yes |
| 3065 | 810 | 810.0 | 24.2 | 24.2 | Pathogenesis of osteoporosis: concepts, conflicts, and prospects. | Lawrence G Raisz | J. Clin. Invest. | 2005 | 16322775 | No |
| 3066 | 810 | 810.0 | 25.65 | 25.6 | Jasmonates: an update on biosynthesis, signal transduction and action in plant stress response, growth and development. | C Wasternack | Ann. Bot. | 2007 | 17513307 | No |
| 3067 | 810 | 810.0 | 17.17 | 17.2 | RNA regulons: coordination of post-transcriptional events. | Jack D Keene | Nat. Rev. Genet. | 2007 | 17572691 | No |
| 3068 | 810 | 810.0 | 28.85 | 28.9 | The global burden of hepatitis C. | Daniel Lavanchy | Liver Int. | 2009 | 19207969 | No |
| 3069 | 2429 | 809.7 | 160.14 | 53.4 | Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. | F Guillemin, C Bombardier, D Beaton | J Clin Epidemiol | 1993 | 8263569 | No |
| 3070 | 1619 | 809.5 | 58.83 | 29.4 | Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. | R A Ignotz, J Massagué | J. Biol. Chem. | 1986 | 3456347 | Yes |
| 3071 | 2428 | 809.3 | 80.13 | 26.7 | The p53 tumour suppressor gene. | A J Levine, J Momand, C A Finlay | Nature | 1991 | 2046748 | No |
| 3072 | 1618 | 809.0 | 74.33 | 37.2 | The Modified Mini-Mental State (3MS) examination. | E L Teng, H C Chui | J Clin Psychiatry | 1987 | 3611032 | Yes |
| 3073 | 809 | 809.0 | 30.77 | 30.8 | Food reward: brain substrates of wanting and liking. | K C Berridge | Neurosci Biobehav Rev | 1996 | 8622814 | No |
| 3074 | 809 | 809.0 | 19.76 | 19.8 | Fluorescence spectroscopy of single biomolecules. | S Weiss | Science | 1999 | 10073925 | No |
| 3075 | 809 | 809.0 | 29.84 | 29.8 | Models of speciation by sexual selection on polygenic traits. | R Lande | Proc. Natl. Acad. Sci. U.S.A. | 1981 | 16593036 | Yes |
| 3076 | 809 | 809.0 | 30.37 | 30.4 | Electrochemical glucose biosensors. | Joseph Wang | Chem. Rev. | 2008 | 18154363 | No |
| 3077 | 809 | 809.0 | 24.77 | 24.8 | Recent advances in neuroblastoma. | John M Maris | N. Engl. J. Med. | 2010 | 20558371 | No |
| 3078 | 1618 | 809.0 | 80.08 | 40.0 | Catalytic dehydrogenative cross-coupling: forming carbon-carbon bonds by oxidizing two carbon-hydrogen bonds. | Charles S Yeung, Vy M Dong | Chem. Rev. | 2011 | 21391561 | Yes |
| 3079 | 809 | 809.0 | 33.89 | 33.9 | Thermal properties of graphene and nanostructured carbon materials. | Alexander A Balandin | Nat Mater | 2011 | 21778997 | Yes |
| 3080 | 2426 | 808.7 | 56.39 | 18.8 | Exploring the metabolic and genetic control of gene expression on a genomic scale. | J L DeRisi, V R Iyer, P O Brown | Science | 1997 | 9381177 | Yes |
| 3081 | 1617 | 808.5 | 43.58 | 21.8 | Regulation of wound healing by growth factors and cytokines. | Sabine Werner, Richard Grose | Physiol. Rev. | 2003 | 12843410 | No |
| 3082 | 808 | 808.0 | 15.94 | 15.9 | Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics. | Lynne E Maquat | Nat. Rev. Mol. Cell Biol. | 2004 | 15040442 | No |
| 3083 | 808 | 808.0 | 41.77 | 41.8 | U.S. Department of Agriculture and U.S. Department of Health and Human Services, Dietary Guidelines for Americans, 2010. 7th Edition, Washington, DC: U.S. Government Printing Office, January 2011. | Shelley McGuire | Adv Nutr | 2011 | 22332062 | Yes |
| 3084 | 1615 | 807.5 | 54.0 | 27.0 | Ageing and Parkinson's disease: substantia nigra regional selectivity. | J M Fearnley, A J Lees | Brain | 1991 | 1933245 | Yes |
| 3085 | 1615 | 807.5 | 37.13 | 18.6 | Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. | S K Hanks, T Hunter | FASEB J. | 1995 | 7768349 | No |
| 3086 | 2421 | 807.0 | 0.0 | 0.0 | High resolution two-dimensional electrophoresis of basic as well as acidic proteins. | P Z O'Farrell, H M Goodman, P H O'Farrell | Cell | 1977 | 23215 | Yes |
| 3087 | 807 | 807.0 | 33.91 | 33.9 | Agents that increase the permeability of the outer membrane. | M Vaara | Microbiol. Rev. | 1992 | 1406489 | No |
| 3088 | 807 | 807.0 | 30.51 | 30.5 | Determinants of tumor blood flow: a review. | R K Jain | Cancer Res. | 1988 | 3282647 | No |
| 3089 | 807 | 807.0 | 33.0 | 33.0 | DNA topoisomerases. | M Gellert | Annu. Rev. Biochem. | 1981 | 6267993 | No |
| 3090 | 807 | 807.0 | 41.62 | 41.6 | Freezing of living cells: mechanisms and implications. | P Mazur | Am. J. Physiol. | 1984 | 6383068 | No |
| 3091 | 807 | 807.0 | 26.2 | 26.2 | Akaike's information criterion in generalized estimating equations. | W Pan | Biometrics | 2001 | 11252586 | Yes |
| 3092 | 2420 | 806.7 | 65.45 | 21.8 | Evolution and functions of long noncoding RNAs. | Chris P Ponting, Peter L Oliver, Wolf Reik | Cell | 2009 | 19239885 | No |
| 3093 | 1613 | 806.5 | 0.0 | 0.0 | Immunization of dissociated spleen cell cultures from normal mice. | R I Mishell, R W Dutton | J. Exp. Med. | 1967 | 6034749 | Yes |
| 3094 | 1613 | 806.5 | 49.24 | 24.6 | Humans integrate visual and haptic information in a statistically optimal fashion. | Marc O Ernst, Martin S Banks | Nature | 2002 | 11807554 | Yes |
| 3095 | 806 | 806.0 | 43.36 | 43.4 | Molecular aspects of ligand binding to serum albumin. | U Kragh-Hansen | Pharmacol. Rev. | 1981 | 7027277 | No |
| 3096 | 806 | 806.0 | 32.73 | 32.7 | Strategies of antioxidant defense. | H Sies | Eur. J. Biochem. | 1993 | 7688300 | No |
| 3097 | 1612 | 806.0 | 28.31 | 14.2 | Analysis of genetic mosaics in developing and adult Drosophila tissues. | T Xu, G M Rubin | Development | 1993 | 8404527 | Yes |
| 3098 | 2418 | 806.0 | 61.47 | 20.5 | BCL-2 family members and the mitochondria in apoptosis. | A Gross, J M McDonnell, S J Korsmeyer | Genes Dev. | 1999 | 10444588 | No |
| 3099 | 806 | 806.0 | 23.33 | 23.3 | Genomewide association studies and assessment of the risk of disease. | Teri A Manolio | N. Engl. J. Med. | 2010 | 20647212 | No |
| 3100 | 806 | 806.0 | 26.18 | 26.2 | Molecular genetics of colorectal cancer. | Eric R Fearon | Annu Rev Pathol | 2011 | 21090969 | No |
| 3101 | 806 | 806.0 | 31.37 | 31.4 | Mitochondria and cancer. | Douglas C Wallace | Nat. Rev. Cancer | 2012 | 23001348 | No |
| 3102 | 1611 | 805.5 | 0.0 | 0.0 | Repeated sequences in DNA. Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. | R J Britten, D E Kohne | Science | 1968 | 4874239 | Yes |
| 3103 | 1611 | 805.5 | 59.18 | 29.6 | Heterogeneous photocatalyst materials for water splitting. | Akihiko Kudo, Yugo Miseki | Chem Soc Rev | 2009 | 19088977 | Yes |
| 3104 | 805 | 805.0 | 0.0 | 0.0 | Isolation of lymphocytes, granulocytes and macrophages. | A Bøyum | Scand. J. Immunol. | 1976 | 1052391 | Yes |
| 3105 | 1610 | 805.0 | 34.68 | 17.3 | Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. | J P Morgenstern, H Land | Nucleic Acids Res. | 1990 | 2194165 | Yes |
| 3106 | 805 | 805.0 | 32.03 | 32.0 | Perceptual load as a necessary condition for selective attention. | N Lavie | J Exp Psychol Hum Percept Perform | 1995 | 7790827 | Yes |
| 3107 | 805 | 805.0 | 39.77 | 39.8 | Gender variations in clinical pain experience. | A M Unruh | Pain | 1996 | 8826503 | No |
| 3108 | 805 | 805.0 | 28.36 | 28.4 | Ion suppression in mass spectrometry. | Thomas M Annesley | Clin. Chem. | 2003 | 12816898 | No |
| 3109 | 805 | 805.0 | 30.46 | 30.5 | The Hospital Anxiety And Depression Scale. | R Philip Snaith | Health Qual Life Outcomes | 2003 | 12914662 | Yes |
| 3110 | 805 | 805.0 | 28.14 | 28.1 | Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes. | R Bonnet | Antimicrob. Agents Chemother. | 2004 | 14693512 | No |
| 3111 | 805 | 805.0 | 46.16 | 46.2 | The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults. | L S Radloff | J Youth Adolesc | 1991 | 24265004 | Yes |
| 3112 | 1608 | 804.0 | 0.0 | 0.0 | Comparative aspects of the brain growth spurt. | J Dobbing, J Sands | Early Hum. Dev. | 1979 | 118862 | Yes |
| 3113 | 804 | 804.0 | 29.93 | 29.9 | A human model of gastric carcinogenesis. | P Correa | Cancer Res. | 1988 | 3288329 | No |
| 3114 | 804 | 804.0 | 23.89 | 23.9 | Lymphokine production by human T cells in disease states. | S Romagnani | Annu. Rev. Immunol. | 1994 | 8011282 | No |
| 3115 | 804 | 804.0 | 21.98 | 22.0 | The molecular biology of leukocyte chemoattractant receptors. | P M Murphy | Annu. Rev. Immunol. | 1994 | 8011292 | No |
| 3116 | 804 | 804.0 | 18.87 | 18.9 | Twilight zone of protein sequence alignments. | B Rost | Protein Eng. | 1999 | 10195279 | Yes |
| 3117 | 804 | 804.0 | 17.35 | 17.4 | Targeting death and decoy receptors of the tumour-necrosis factor superfamily. | Avi Ashkenazi | Nat. Rev. Cancer | 2002 | 12189384 | No |
| 3118 | 804 | 804.0 | 22.69 | 22.7 | Metagenomics: application of genomics to uncultured microorganisms. | Jo Handelsman | Microbiol. Mol. Biol. Rev. | 2004 | 15590779 | No |
| 3119 | 804 | 804.0 | 18.56 | 18.6 | Nonlinear structured-illumination microscopy: wide-field fluorescence imaging with theoretically unlimited resolution. | Mats G L Gustafsson | Proc. Natl. Acad. Sci. U.S.A. | 2005 | 16141335 | Yes |
| 3120 | 804 | 804.0 | 0.0 | 0.0 | On the local reactions of the arterial wall to changes of internal pressure. | W M Bayliss | J. Physiol. (Lond.) | 1902 | 16992618 | Yes |
| 3121 | 804 | 804.0 | 0.0 | 0.0 | Limitations of the application of fourfold table analysis to hospital data. | J BERKSON | Biometrics | 1946 | 21001024 | Yes |
| 3122 | 5625 | 803.6 | 355.92 | 50.8 | limma powers differential expression analyses for RNA-sequencing and microarray studies. | Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth | Nucleic Acids Res. | 2015 | 25605792 | Yes |
| 3123 | 1607 | 803.5 | 44.53 | 22.3 | Cell cycle, CDKs and cancer: a changing paradigm. | Marcos Malumbres, Mariano Barbacid | Nat. Rev. Cancer | 2009 | 19238148 | No |
| 3124 | 803 | 803.0 | 46.04 | 46.0 | The pineal and its hormones in the control of reproduction in mammals. | R J Reiter | Endocr. Rev. | 1980 | 6263600 | No |
| 3125 | 803 | 803.0 | 35.95 | 36.0 | Lipid peroxidation and antioxidants as biomarkers of tissue damage. | J M Gutteridge | Clin. Chem. | 1995 | 7497639 | No |
| 3126 | 1606 | 803.0 | 56.47 | 28.2 | Leukocyte-endothelial adhesion molecules. | T M Carlos, J M Harlan | Blood | 1994 | 7522621 | No |
| 3127 | 803 | 803.0 | 21.01 | 21.0 | PHD: predicting one-dimensional protein structure by profile-based neural networks. | B Rost | Meth. Enzymol. | 1996 | 8743704 | Yes |
| 3128 | 803 | 803.0 | 0.0 | 0.0 | A production of amino acids under possible primitive earth conditions. | S L MILLER | Science | 1953 | 13056598 | Yes |
| 3129 | 1606 | 803.0 | 48.01 | 24.0 | Adipocytokines: mediators linking adipose tissue, inflammation and immunity. | Herbert Tilg, Alexander R Moschen | Nat. Rev. Immunol. | 2006 | 16998510 | No |
| 3130 | 803 | 803.0 | 31.88 | 31.9 | Understanding diagnostic tests 3: Receiver operating characteristic curves. | Anthony K Akobeng | Acta Paediatr. | 2007 | 17376185 | No |
| 3131 | 2408 | 802.7 | 53.25 | 17.8 | Genetic instabilities in human cancers. | C Lengauer, K W Kinzler, B Vogelstein | Nature | 1998 | 9872311 | No |
| 3132 | 1605 | 802.5 | 80.04 | 40.0 | Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. | H Esterbauer, K H Cheeseman | Meth. Enzymol. | 1990 | 2233308 | Yes |
| 3133 | 3210 | 802.5 | 91.53 | 22.9 | DnaSP, DNA polymorphism analyses by the coalescent and other methods. | Julio Rozas, Juan C Sánchez-DelBarrio, Xavier Messeguer, Ricardo Rozas | Bioinformatics | 2003 | 14668244 | Yes |
| 3134 | 2407 | 802.3 | 0.0 | 0.0 | Depression: a new animal model sensitive to antidepressant treatments. | R D Porsolt, M Le Pichon, M Jalfre | Nature | 1977 | 559941 | Yes |
| 3135 | 802 | 802.0 | 27.36 | 27.4 | Receptors for epidermal growth factor and other polypeptide mitogens. | G Carpenter | Annu. Rev. Biochem. | 1987 | 3039909 | No |
| 3136 | 802 | 802.0 | 34.13 | 34.1 | beta-Lactamases in laboratory and clinical resistance. | D M Livermore | Clin. Microbiol. Rev. | 1995 | 8665470 | No |
| 3137 | 802 | 802.0 | 26.31 | 26.3 | Interval estimation for the difference between independent proportions: comparison of eleven methods. | R G Newcombe | Stat Med | 1998 | 9595617 | Yes |
| 3138 | 802 | 802.0 | 19.27 | 19.3 | Phylogenetic classification and the universal tree. | W F Doolittle | Science | 1999 | 10381871 | No |
| 3139 | 1604 | 802.0 | 36.01 | 18.0 | Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. | P E Wright, H J Dyson | J. Mol. Biol. | 1999 | 10550212 | No |
| 3140 | 1604 | 802.0 | 52.15 | 26.1 | Fitness effects on the cognitive function of older adults: a meta-analytic study. | Stanley Colcombe, Arthur F Kramer | Psychol Sci | 2003 | 12661673 | Yes |
| 3141 | 802 | 802.0 | 0.0 | 0.0 | Nutrition needs of mammalian cells in tissue culture. | H EAGLE | Science | 1955 | 13255879 | Yes |
| 3142 | 802 | 802.0 | 0.0 | 0.0 | On the psychophysical law. | S S STEVENS | Psychol Rev | 1957 | 13441853 | Yes |
| 3143 | 1604 | 802.0 | 61.09 | 30.5 | Health effects of fine particulate air pollution: lines that connect. | C Arden Pope, Douglas W Dockery | J Air Waste Manag Assoc | 2006 | 16805397 | No |
| 3144 | 802 | 802.0 | 22.94 | 22.9 | Lead- and drug-like compounds: the rule-of-five revolution. | Christopher A Lipinski | Drug Discov Today Technol | 2004 | 24981612 | Yes |
| 3145 | 4009 | 801.8 | 157.7 | 31.5 | Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. | Salim Yusuf, Bertram Pitt, Clarence E Davis, William B Hood, Jay N Cohn | N. Engl. J. Med. | 1991 | 2057034 | Yes |
| 3146 | 1603 | 801.5 | 0.0 | 0.0 | Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt, and Detonula confervacea (cleve) Gran. | R R GUILLARD, J H RYTHER | Can. J. Microbiol. | 1962 | 13902807 | Yes |
| 3147 | 4007 | 801.4 | 116.08 | 23.2 | Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. | Z Xia, M Dickens, J Raingeaud, R J Davis, M E Greenberg | Science | 1995 | 7481820 | Yes |
| 3148 | 3205 | 801.2 | 115.45 | 28.9 | SENSE: sensitivity encoding for fast MRI. | K P Pruessmann, M Weiger, M B Scheidegger, P Boesiger | Magn Reson Med | 1999 | 10542355 | Yes |
| 3149 | 801 | 801.0 | 26.6 | 26.6 | The role of angiogenesis in tumor growth. | J Folkman | Semin. Cancer Biol. | 1992 | 1378311 | No |
| 3150 | 801 | 801.0 | 27.06 | 27.1 | Axonal growth-associated proteins. | J H Skene | Annu. Rev. Neurosci. | 1989 | 2648946 | No |
| 3151 | 801 | 801.0 | 0.0 | 0.0 | The epidemiologic transition. A theory of the epidemiology of population change. | A R Omran | Milbank Mem Fund Q | 1971 | 5155251 | Yes |
| 3152 | 3204 | 801.0 | 148.05 | 37.0 | Guidelines for the process of cross-cultural adaptation of self-report measures. | D E Beaton, C Bombardier, F Guillemin, M B Ferraz | Spine | 2000 | 11124735 | No |
| 3153 | 801 | 801.0 | 16.94 | 16.9 | Computational systems biology. | Hiroaki Kitano | Nature | 2002 | 12432404 | No |
| 3154 | 4001 | 800.2 | 134.93 | 27.0 | Quantitative assessment of tactile allodynia in the rat paw. | S R Chaplan, F W Bach, J W Pogrel, J M Chung, T L Yaksh | J. Neurosci. Methods | 1994 | 7990513 | Yes |
| 3155 | 800 | 800.0 | 40.09 | 40.1 | Omega-3 fatty acids in health and disease and in growth and development. | A P Simopoulos | Am. J. Clin. Nutr. | 1991 | 1908631 | No |
| 3156 | 800 | 800.0 | 18.49 | 18.5 | Molecular signatures of natural selection. | Rasmus Nielsen | Annu. Rev. Genet. | 2005 | 16285858 | No |
| 3157 | 800 | 800.0 | 32.61 | 32.6 | The World Health Report 2006: working together for health. | J-J Guilbert | Educ Health (Abingdon) | 2006 | 17178522 | Yes |
| 3158 | 800 | 800.0 | 46.28 | 46.3 | Working memory: theories, models, and controversies. | Alan Baddeley | Annu Rev Psychol | 2012 | 21961947 | No |
| 3159 | 799 | 799.0 | 24.14 | 24.1 | High-sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease. | P M Ridker | Circulation | 2001 | 11282915 | Yes |
| 3160 | 799 | 799.0 | 17.43 | 17.4 | Progress in human tumour immunology and immunotherapy. | S A Rosenberg | Nature | 2001 | 11357146 | No |
| 3161 | 799 | 799.0 | 26.85 | 26.9 | Invited review: Aging and sarcopenia. | Timothy J Doherty | J. Appl. Physiol. | 2003 | 12970377 | No |
| 3162 | 799 | 799.0 | 36.03 | 36.0 | The role of autophagy in neurodegenerative disease. | Ralph A Nixon | Nat. Med. | 2013 | 23921753 | No |
| 3163 | 2396 | 798.7 | 164.11 | 54.7 | Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG) | P L Hudak, P C Amadio, C Bombardier | Am. J. Ind. Med. | 1996 | 8773720 | Yes |
| 3164 | 1597 | 798.5 | 0.0 | 0.0 | Construct validity in psychological tests. | L J CRONBACH, P E MEEHL | Psychol Bull | 1955 | 13245896 | Yes |
| 3165 | 1597 | 798.5 | 42.66 | 21.3 | Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. | Daniel J Hicklin, Lee M Ellis | J. Clin. Oncol. | 2005 | 15585754 | No |
| 3166 | 798 | 798.0 | 53.1 | 53.1 | Molecular pathology of schizophrenia: more than one disease process? | T J Crow | Br Med J | 1980 | 6101544 | No |
| 3167 | 798 | 798.0 | 33.26 | 33.3 | The oxidation hypothesis of atherosclerosis. | J L Witztum | Lancet | 1994 | 7916078 | No |
| 3168 | 2394 | 798.0 | 55.2 | 18.4 | SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. | Jay D Horton, Joseph L Goldstein, Michael S Brown | J. Clin. Invest. | 2002 | 11994399 | No |
| 3169 | 798 | 798.0 | 17.92 | 17.9 | The plasticity of aging: insights from long-lived mutants. | Cynthia Kenyon | Cell | 2005 | 15734678 | No |
| 3170 | 1596 | 798.0 | 48.66 | 24.3 | Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. | S Schulman, C Kearon | J. Thromb. Haemost. | 2005 | 15842354 | Yes |
| 3171 | 798 | 798.0 | 23.06 | 23.1 | Solid-state nanopores. | Cees Dekker | Nat Nanotechnol | 2007 | 18654264 | No |
| 3172 | 798 | 798.0 | 49.75 | 49.8 | Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement. | Virginia A Moyer | Ann. Intern. Med. | 2014 | 24378917 | No |
| 3173 | 1594 | 797.0 | 56.09 | 28.0 | Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis. | D C Schwartz, C R Cantor | Cell | 1984 | 6373014 | Yes |
| 3174 | 797 | 797.0 | 24.07 | 24.1 | Intracellular protein topogenesis. | G Blobel | Proc. Natl. Acad. Sci. U.S.A. | 1980 | 6929499 | Yes |
| 3175 | 797 | 797.0 | 15.43 | 15.4 | Oncogenic transcription factors in the human acute leukemias. | A T Look | Science | 1997 | 9353180 | No |
| 3176 | 797 | 797.0 | 18.82 | 18.8 | Prospects for whole-genome linkage disequilibrium mapping of common disease genes. | L Kruglyak | Nat. Genet. | 1999 | 10369254 | Yes |
| 3177 | 1594 | 797.0 | 33.78 | 16.9 | Transcriptional regulation by the phosphorylation-dependent factor CREB. | B Mayr, M Montminy | Nat. Rev. Mol. Cell Biol. | 2001 | 11483993 | No |
| 3178 | 797 | 797.0 | 34.8 | 34.8 | Predictors of postpartum depression: an update. | C T Beck | Nurs Res | 2001 | 11570712 | Yes |
| 3179 | 797 | 797.0 | 22.69 | 22.7 | A Population-Average, Landmark- and Surface-based (PALS) atlas of human cerebral cortex. | David C Van Essen | Neuroimage | 2005 | 16172003 | Yes |
| 3180 | 1593 | 796.5 | 59.8 | 29.9 | The acute phase response. | H Baumann, J Gauldie | Immunol. Today | 1994 | 7512342 | No |
| 3181 | 2389 | 796.3 | 90.05 | 30.0 | Health benefits of physical activity: the evidence. | Darren E R Warburton, Crystal Whitney Nicol, Shannon S D Bredin | CMAJ | 2006 | 16534088 | No |
| 3182 | 8759 | 796.3 | 283.9 | 25.8 | The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. | Aaron McKenna, Matthew Hanna, Eric Banks, Andrey Sivachenko, Kristian Cibulskis, Andrew Kernytsky, Kiran Garimella, David Altshuler, Stacey Gabriel, Mark Daly, Mark A DePristo | Genome Res. | 2010 | 20644199 | Yes |
| 3183 | 2388 | 796.0 | 67.62 | 22.5 | Nitric oxide and macrophage function. | J MacMicking, Q W Xie, C Nathan | Annu. Rev. Immunol. | 1997 | 9143691 | No |
| 3184 | 1592 | 796.0 | 53.96 | 27.0 | The capacity of visual working memory for features and conjunctions. | S J Luck, E K Vogel | Nature | 1997 | 9384378 | Yes |
| 3185 | 1592 | 796.0 | 38.22 | 19.1 | A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach. | S Whelan, N Goldman | Mol. Biol. Evol. | 2001 | 11319253 | Yes |
| 3186 | 796 | 796.0 | 33.19 | 33.2 | Breakthrough of the year 2013. Cancer immunotherapy. | Jennifer Couzin-Frankel | Science | 2013 | 24357284 | No |
| 3187 | 2387 | 795.7 | 0.0 | 0.0 | Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. | A L Shapiro, E Viñuela, J V Maizel | Biochem. Biophys. Res. Commun. | 1967 | 4861258 | Yes |
| 3188 | 1591 | 795.5 | 39.31 | 19.7 | A molecular mechanism for the effect of lithium on development. | P S Klein, D A Melton | Proc. Natl. Acad. Sci. U.S.A. | 1996 | 8710892 | Yes |
| 3189 | 795 | 795.0 | 38.54 | 38.5 | Multiple organ failure. Pathophysiology and potential future therapy. | E A Deitch | Ann. Surg. | 1992 | 1503516 | No |
| 3190 | 795 | 795.0 | 0.0 | 0.0 | Voluntary strength and fatigue. | P A MERTON | J. Physiol. (Lond.) | 1954 | 13152698 | Yes |
| 3191 | 795 | 795.0 | 16.62 | 16.6 | Ubiquitin signalling in the NF-kappaB pathway. | Zhijian J Chen | Nat. Cell Biol. | 2005 | 16056267 | No |
| 3192 | 795 | 795.0 | 22.59 | 22.6 | Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. | Thomas A Wynn | J. Clin. Invest. | 2007 | 17332879 | No |
| 3193 | 1589 | 794.5 | 37.51 | 18.8 | The biology of chemokines and their receptors. | D Rossi, A Zlotnik | Annu. Rev. Immunol. | 2000 | 10837058 | No |
| 3194 | 1589 | 794.5 | 55.4 | 27.7 | Tumor metastasis: molecular insights and evolving paradigms. | Scott Valastyan, Robert A Weinberg | Cell | 2011 | 22000009 | No |
| 3195 | 794 | 794.0 | 23.75 | 23.8 | Formation and function of the myofibroblast during tissue repair. | Boris Hinz | J. Invest. Dermatol. | 2007 | 17299435 | No |
| 3196 | 1588 | 794.0 | 88.8 | 44.4 | The M1 and M2 paradigm of macrophage activation: time for reassessment. | Fernando O Martinez, Siamon Gordon | F1000Prime Rep | 2014 | 24669294 | No |
| 3197 | 1587 | 793.5 | 68.19 | 34.1 | Modeling and comparison of dissolution profiles. | P Costa, J M Sousa Lobo | Eur J Pharm Sci | 2001 | 11297896 | No |
| 3198 | 1587 | 793.5 | 45.27 | 22.6 | ZINC--a free database of commercially available compounds for virtual screening. | John J Irwin, Brian K Shoichet | J Chem Inf Model | 2005 | 15667143 | Yes |
| 3199 | 793 | 793.0 | 29.54 | 29.5 | Qinghaosu (artemisinin): an antimalarial drug from China. | D L Klayman | Science | 1985 | 3887571 | No |
| 3200 | 1586 | 793.0 | 85.0 | 42.5 | The stunned myocardium: prolonged, postischemic ventricular dysfunction. | E Braunwald, R A Kloner | Circulation | 1982 | 6754130 | No |
| 3201 | 793 | 793.0 | 22.98 | 23.0 | Variation in protection by BCG: implications of and for heterologous immunity. | P E Fine | Lancet | 1995 | 7475776 | No |
| 3202 | 793 | 793.0 | 23.41 | 23.4 | Skeletal complications of malignancy. | R E Coleman | Cancer | 1997 | 9362426 | No |
| 3203 | 793 | 793.0 | 23.52 | 23.5 | Functional MRI of language: new approaches to understanding the cortical organization of semantic processing. | Susan Bookheimer | Annu. Rev. Neurosci. | 2002 | 12052907 | No |
| 3204 | 793 | 793.0 | 0.0 | 0.0 | An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. | O SMITHIES | Biochem. J. | 1959 | 13638269 | Yes |
| 3205 | 793 | 793.0 | 20.93 | 20.9 | Viruses in the sea. | Curtis A Suttle | Nature | 2005 | 16163346 | No |
| 3206 | 1586 | 793.0 | 47.96 | 24.0 | Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. | Subhra K Biswas, Alberto Mantovani | Nat. Immunol. | 2010 | 20856220 | No |
| 3207 | 792 | 792.0 | 46.55 | 46.5 | Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). | S Safe | Crit. Rev. Toxicol. | 1990 | 2124811 | No |
| 3208 | 792 | 792.0 | 22.12 | 22.1 | Shattuck lecture--cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities. | E Braunwald | N. Engl. J. Med. | 1997 | 9358131 | No |
| 3209 | 792 | 792.0 | 24.12 | 24.1 | Mode of action of membrane active antimicrobial peptides. | Yechiel Shai | Biopolymers | 2002 | 12491537 | No |
| 3210 | 792 | 792.0 | 55.32 | 55.3 | Computing Inter-Rater Reliability for Observational Data: An Overview and Tutorial. | Kevin A Hallgren | Tutor Quant Methods Psychol | 2012 | 22833776 | Yes |
| 3211 | 3167 | 791.8 | 176.88 | 44.2 | Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. | Katherine M Flegal, Margaret D Carroll, Brian K Kit, Cynthia L Ogden | JAMA | 2012 | 22253363 | Yes |
| 3212 | 1583 | 791.5 | 52.83 | 26.4 | The regulation and function of c-fos and other immediate early genes in the nervous system. | M Sheng, M E Greenberg | Neuron | 1990 | 1969743 | No |
| 3213 | 1583 | 791.5 | 37.22 | 18.6 | High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier. | R H Schiestl, R D Gietz | Curr. Genet. | 1989 | 2692852 | Yes |
| 3214 | 1583 | 791.5 | 71.7 | 35.9 | Understanding face recognition. | V Bruce, A Young | Br J Psychol | 1986 | 3756376 | Yes |
| 3215 | 3166 | 791.5 | 89.95 | 22.5 | The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. | R M Kluck, E Bossy-Wetzel, D R Green, D D Newmeyer | Science | 1997 | 9027315 | Yes |
| 3216 | 7121 | 791.2 | 326.63 | 36.3 | A novel potent vasoconstrictor peptide produced by vascular endothelial cells. | M Yanagisawa, H Kurihara, S Kimura, Y Tomobe, M Kobayashi, Y Mitsui, Y Yazaki, K Goto, T Masaki | Nature | 1988 | 2451132 | Yes |
| 3217 | 1582 | 791.0 | 0.0 | 0.0 | Establishment and characterization of a human histiocytic lymphoma cell line (U-937). | C Sundström, K Nilsson | Int. J. Cancer | 1976 | 178611 | Yes |
| 3218 | 1582 | 791.0 | 52.4 | 26.2 | DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. | S Tabor, C C Richardson | Proc. Natl. Acad. Sci. U.S.A. | 1987 | 3474623 | Yes |
| 3219 | 791 | 791.0 | 34.02 | 34.0 | Calcium channel modulation by neurotransmitters, enzymes and drugs. | H Reuter | Nature | 1983 | 6131381 | No |
| 3220 | 791 | 791.0 | 39.44 | 39.4 | Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. | W A Catterall | Annu. Rev. Pharmacol. Toxicol. | 1980 | 6247957 | No |
| 3221 | 3164 | 791.0 | 98.15 | 24.5 | A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. | I Vermes, C Haanen, H Steffens-Nakken, C Reutelingsperger | J. Immunol. Methods | 1995 | 7622868 | Yes |
| 3222 | 1582 | 791.0 | 39.42 | 19.7 | Cell locomotion and focal adhesions are regulated by substrate flexibility. | R J Pelham, Y l Wang | Proc. Natl. Acad. Sci. U.S.A. | 1997 | 9391082 | Yes |
| 3223 | 791 | 791.0 | 17.98 | 18.0 | Genome evolution in polyploids. | J F Wendel | Plant Mol. Biol. | 2000 | 10688139 | No |
| 3224 | 791 | 791.0 | 27.55 | 27.6 | AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. | D Grahame Hardie | Genes Dev. | 2011 | 21937710 | No |
| 3225 | 1581 | 790.5 | 36.39 | 18.2 | Autophagy in health and disease: a double-edged sword. | Takahiro Shintani, Daniel J Klionsky | Science | 2004 | 15528435 | No |
| 3226 | 1581 | 790.5 | 60.87 | 30.4 | Accessories to the crime: functions of cells recruited to the tumor microenvironment. | Douglas Hanahan, Lisa M Coussens | Cancer Cell | 2012 | 22439926 | No |
| 3227 | 2371 | 790.3 | 70.49 | 23.5 | Ghrelin induces adiposity in rodents. | M Tschöp, D L Smiley, M L Heiman | Nature | 2000 | 11057670 | Yes |
| 3228 | 790 | 790.0 | 30.64 | 30.6 | Clinical practice. Preventing falls in elderly persons. | Mary E Tinetti | N. Engl. J. Med. | 2003 | 12510042 | No |
| 3229 | 790 | 790.0 | 0.0 | 0.0 | Notes on continuous stochastic phenomena. | P A P MORAN | Biometrika | 1950 | 15420245 | Yes |
| 3230 | 1580 | 790.0 | 36.3 | 18.1 | Phosphoinositides in cell regulation and membrane dynamics. | Gilbert Di Paolo, Pietro De Camilli | Nature | 2006 | 17035995 | No |
| 3231 | 790 | 790.0 | 0.0 | 0.0 | The generalisation of student's problems when several different population variances are involved. | B L WELCH | Biometrika | 1947 | 20287819 | Yes |
| 3232 | 1579 | 789.5 | 65.21 | 32.6 | Caregiving as a risk factor for mortality: the Caregiver Health Effects Study. | R Schulz, S R Beach | JAMA | 1999 | 10605972 | Yes |
| 3233 | 789 | 789.0 | 0.0 | 0.0 | Structure of chromatin. | R D Kornberg | Annu. Rev. Biochem. | 1977 | 332067 | No |
| 3234 | 789 | 789.0 | 0.0 | 0.0 | Tests for emotionality in rats and mice: a review. | J Archer | Anim Behav | 1973 | 4578750 | No |
| 3235 | 789 | 789.0 | 26.04 | 26.0 | Cellular mechanisms for heavy metal detoxification and tolerance. | J L Hall | J. Exp. Bot. | 2002 | 11741035 | No |
| 3236 | 1578 | 789.0 | 48.8 | 24.4 | Anemia of chronic disease. | Guenter Weiss, Lawrence T Goodnough | N. Engl. J. Med. | 2005 | 15758012 | No |
| 3237 | 4731 | 788.5 | 136.22 | 22.7 | Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. | D C Angus, W T Linde-Zwirble, J Lidicker, G Clermont, J Carcillo, M R Pinsky | Crit. Care Med. | 2001 | 11445675 | Yes |
| 3238 | 2365 | 788.3 | 64.29 | 21.4 | Consed: a graphical tool for sequence finishing. | D Gordon, C Abajian, P Green | Genome Res. | 1998 | 9521923 | Yes |
| 3239 | 1576 | 788.0 | 56.43 | 28.2 | Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. | C N Hales, D J Barker | Diabetologia | 1992 | 1644236 | No |
| 3240 | 788 | 788.0 | 30.42 | 30.4 | What is synergy? | M C Berenbaum | Pharmacol. Rev. | 1989 | 2692037 | No |
| 3241 | 1576 | 788.0 | 59.78 | 29.9 | Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. | J M Reul, E R de Kloet | Endocrinology | 1985 | 2998738 | Yes |
| 3242 | 1576 | 788.0 | 46.36 | 23.2 | The amygdala: vigilance and emotion. | M Davis, P J Whalen | Mol. Psychiatry | 2001 | 11244481 | No |
| 3243 | 1576 | 788.0 | 70.54 | 35.3 | Efficacy of the Theory of Planned Behaviour: a meta-analytic review. | C J Armitage, M Conner | Br J Soc Psychol | 2001 | 11795063 | Yes |
| 3244 | 788 | 788.0 | 22.67 | 22.7 | Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. | Mark E Bouton | Biol. Psychiatry | 2002 | 12437938 | No |
| 3245 | 788 | 788.0 | 17.97 | 18.0 | Validating survivin as a cancer therapeutic target. | Dario C Altieri | Nat. Rev. Cancer | 2003 | 12509766 | No |
| 3246 | 1576 | 788.0 | 43.93 | 22.0 | Establishing, maintaining and modifying DNA methylation patterns in plants and animals. | Julie A Law, Steven E Jacobsen | Nat. Rev. Genet. | 2010 | 20142834 | No |
| 3247 | 2363 | 787.7 | 72.31 | 24.1 | Use and abuse of HOMA modeling. | Tara M Wallace, Jonathan C Levy, David R Matthews | Diabetes Care | 2004 | 15161807 | No |
| 3248 | 2363 | 787.7 | 120.67 | 40.2 | Multiple imputation using chained equations: Issues and guidance for practice. | Ian R White, Patrick Royston, Angela M Wood | Stat Med | 2011 | 21225900 | Yes |
| 3249 | 1575 | 787.5 | 51.58 | 25.8 | The metabotropic glutamate receptors: structure and functions. | J P Pin, R Duvoisin | Neuropharmacology | 1995 | 7623957 | No |
| 3250 | 1575 | 787.5 | 58.44 | 29.2 | Multiple significance tests: the Bonferroni method. | J M Bland, D G Altman | BMJ | 1995 | 7833759 | Yes |
| 3251 | 1575 | 787.5 | 42.97 | 21.5 | Caspases: killer proteases. | D W Nicholson, N A Thornberry | Trends Biochem. Sci. | 1997 | 9270303 | No |
| 3252 | 1575 | 787.5 | 28.83 | 14.4 | Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. | Lee Zou, Stephen J Elledge | Science | 2003 | 12791985 | Yes |
| 3253 | 787 | 787.0 | 25.13 | 25.1 | Correction for liquid junction potentials in patch clamp experiments. | E Neher | Meth. Enzymol. | 1992 | 1528115 | Yes |
| 3254 | 2361 | 787.0 | 158.93 | 53.0 | Assessing coping strategies: a theoretically based approach. | C S Carver, M F Scheier, J K Weintraub | J Pers Soc Psychol | 1989 | 2926629 | Yes |
| 3255 | 787 | 787.0 | 35.08 | 35.1 | Basic mathematical and electromagnetic concepts of the biomagnetic inverse problem. | J Sarvas | Phys Med Biol | 1987 | 3823129 | Yes |
| 3256 | 787 | 787.0 | 26.45 | 26.4 | Primary pulmonary hypertension. | L J Rubin | N. Engl. J. Med. | 1997 | 8988890 | No |
| 3257 | 787 | 787.0 | 0.0 | 0.0 | Effects of varying the vehicle for OsO4 in tissue fixation. | J B CAULFIELD | J Biophys Biochem Cytol | 1957 | 13475399 | Yes |
| 3258 | 3147 | 786.8 | 64.5 | 16.1 | DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. | M Okano, D W Bell, D A Haber, E Li | Cell | 1999 | 10555141 | Yes |
| 3259 | 3145 | 786.2 | 79.37 | 19.8 | SWISS-MODEL: An automated protein homology-modeling server. | Torsten Schwede, Jürgen Kopp, Nicolas Guex, Manuel C Peitsch | Nucleic Acids Res. | 2003 | 12824332 | Yes |
| 3260 | 1572 | 786.0 | 49.94 | 25.0 | The evolution of cooperation. | R Axelrod, W D Hamilton | Science | 1981 | 7466396 | Yes |
| 3261 | 1572 | 786.0 | 52.06 | 26.0 | The mitochondrial permeability transition. | M Zoratti, I Szabò | Biochim. Biophys. Acta | 1995 | 7640294 | No |
| 3262 | 786 | 786.0 | 24.71 | 24.7 | The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. | David S Ludwig | JAMA | 2002 | 11988062 | No |
| 3263 | 786 | 786.0 | 21.15 | 21.1 | Liver regeneration. | George K Michalopoulos | J. Cell. Physiol. | 2007 | 17559071 | No |
| 3264 | 4713 | 785.5 | 138.9 | 23.2 | An obesity-associated gut microbiome with increased capacity for energy harvest. | Peter J Turnbaugh, Ruth E Ley, Michael A Mahowald, Vincent Magrini, Elaine R Mardis, Jeffrey I Gordon | Nature | 2006 | 17183312 | Yes |
| 3265 | 785 | 785.0 | 21.19 | 21.2 | Toward self-organization and complex matter. | Jean-Marie Lehn | Science | 2002 | 11923524 | Yes |
| 3266 | 785 | 785.0 | 20.12 | 20.1 | A likelihood approach to estimating phylogeny from discrete morphological character data. | P O Lewis | Syst. Biol. | 2001 | 12116640 | Yes |
| 3267 | 1569 | 784.5 | 0.0 | 0.0 | Construction of phylogenetic trees. | W M Fitch, E Margoliash | Science | 1967 | 5334057 | No |
| 3268 | 1569 | 784.5 | 32.95 | 16.5 | Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method. | R Daniel Gietz, Robin A Woods | Meth. Enzymol. | 2002 | 12073338 | Yes |
| 3269 | 1569 | 784.5 | 47.62 | 23.8 | Mesenchymal stem cells as trophic mediators. | Arnold I Caplan, James E Dennis | J. Cell. Biochem. | 2006 | 16619257 | No |
| 3270 | 784 | 784.0 | 17.77 | 17.8 | Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates. | D R Cavener | Nucleic Acids Res. | 1987 | 3822832 | Yes |
| 3271 | 784 | 784.0 | 0.0 | 0.0 | Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. | J O Holloszy | J. Biol. Chem. | 1967 | 4290225 | Yes |
| 3272 | 784 | 784.0 | 0.0 | 0.0 | Time-dependent processes in memory storage. | J L McGaugh | Science | 1966 | 5917768 | Yes |
| 3273 | 784 | 784.0 | 35.24 | 35.2 | Methods for dealing with reaction time outliers. | R Ratcliff | Psychol Bull | 1993 | 8272468 | Yes |
| 3274 | 784 | 784.0 | 34.01 | 34.0 | How stigma interferes with mental health care. | Patrick Corrigan | Am Psychol | 2004 | 15491256 | Yes |
| 3275 | 784 | 784.0 | 18.22 | 18.2 | Understanding the odd science of aging. | Thomas B L Kirkwood | Cell | 2005 | 15734677 | No |
| 3276 | 784 | 784.0 | 25.33 | 25.3 | Thermo- and pH-responsive polymers in drug delivery. | Dirk Schmaljohann | Adv. Drug Deliv. Rev. | 2006 | 17125884 | No |
| 3277 | 1567 | 783.5 | 0.0 | 0.0 | Hearing lips and seeing voices. | H McGurk, J MacDonald | Nature | 1976 | 1012311 | Yes |
| 3278 | 1567 | 783.5 | 32.98 | 16.5 | An automated method for finding molecular complexes in large protein interaction networks. | Gary D Bader, Christopher W V Hogue | BMC Bioinformatics | 2003 | 12525261 | Yes |
| 3279 | 783 | 783.0 | 33.8 | 33.8 | Biosynthesis and metabolism of endothelium-derived nitric oxide. | L J Ignarro | Annu. Rev. Pharmacol. Toxicol. | 1990 | 2188578 | No |
| 3280 | 783 | 783.0 | 26.83 | 26.8 | On the utility of P3 amplitude as a measure of processing capacity. | A Kok | Psychophysiology | 2001 | 11352145 | No |
| 3281 | 783 | 783.0 | 20.88 | 20.9 | Angiogenesis. | Judah Folkman | Annu. Rev. Med. | 2006 | 16409133 | No |
| 3282 | 783 | 783.0 | 20.15 | 20.1 | Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. | Michael Forgac | Nat. Rev. Mol. Cell Biol. | 2007 | 17912264 | No |
| 3283 | 783 | 783.0 | 18.31 | 18.3 | Models, mechanisms and clinical evidence for cancer dormancy. | Julio A Aguirre-Ghiso | Nat. Rev. Cancer | 2007 | 17957189 | No |
| 3284 | 783 | 783.0 | 20.19 | 20.2 | Hypoxia, HIF1 and glucose metabolism in the solid tumour. | Nicholas C Denko | Nat. Rev. Cancer | 2008 | 19143055 | No |
| 3285 | 4698 | 783.0 | 176.09 | 29.3 | A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. | Martin Jinek, Krzysztof Chylinski, Ines Fonfara, Michael Hauer, Jennifer A Doudna, Emmanuelle Charpentier | Science | 2012 | 22745249 | Yes |
| 3286 | 2347 | 782.3 | 78.46 | 26.2 | Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. | Robert D Schreiber, Lloyd J Old, Mark J Smyth | Science | 2011 | 21436444 | No |
| 3287 | 782 | 782.0 | 0.0 | 0.0 | Evolution and tinkering. | F Jacob | Science | 1977 | 860134 | Yes |
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