Unicorn Papers

Top ‱ cited papers from PUBMED

Unicorn Papers are based on an equal contribution (EC) citation model in which the total number of citations had been divided by the number of the authors
Currently, the list contains 3287 papers with ECcit ≥ 782.0
‱ - permyriad, , literally meaning "for (every) myriad (ten thousand)"

Volume 1, September 2020

No. Citations ECcit RCR ECRCR Title Authors Journal Year PMID Article(?)
1159932159932.00.00.0Cleavage of structural proteins during the assembly of the head of bacteriophage T4. U K LaemmliNature19705432063Yes
2129141129141.00.00.0A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. M M BradfordAnal. Biochem.1976942051Yes
319077447693.50.00.0Protein measurement with the Folin phenol reagent. O H LOWRY, N J ROSEBROUGH, A L FARR, R J RANDALLJ. Biol. Chem.195114907713Yes
43867638676.01546.391546.4A short history of SHELX. George M SheldrickActa Crystallogr., A, Found. Crystallogr.200818156677Yes
57312136560.52096.51048.2Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. K J Livak, T D SchmittgenMethods200111846609Yes
62492424924.01042.651042.7Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. T MosmannJ. Immunol. Methods19836606682Yes
72289622896.00.00.0Detection of specific sequences among DNA fragments separated by gel electrophoresis. E M SouthernJ. Mol. Biol.19751195397Yes
84515922579.51853.24926.6Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. P Chomczynski, N SacchiAnal. Biochem.19872440339Yes
92049420494.00.00.0The assessment and analysis of handedness: the Edinburgh inventory. R C OldfieldNeuropsychologia19715146491Yes
102035520355.0506.03506.0MicroRNAs: genomics, biogenesis, mechanism, and function. David P BartelCell200414744438No
111769617696.0463.68463.7A new mathematical model for relative quantification in real-time RT-PCR. M W PfafflNucleic Acids Res.200111328886Yes
121739617396.0471.24471.2MUSCLE: multiple sequence alignment with high accuracy and high throughput. Robert C EdgarNucleic Acids Res.200415034147Yes
131659116591.00.00.0A rating scale for depression. M HAMILTONJ. Neurol. Neurosurg. Psychiatry196014399272Yes
144590115300.30.00.0"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. M F Folstein, S E Folstein, P R McHughJ Psychiatr Res19751202204Yes
153008415042.01132.15566.1The neighbor-joining method: a new method for reconstructing phylogenetic trees. N Saitou, M NeiMol. Biol. Evol.19873447015Yes
164463214877.30.00.0DNA sequencing with chain-terminating inhibitors. F Sanger, S Nicklen, A R CoulsonProc. Natl. Acad. Sci. U.S.A.1977271968Yes
171387513875.00.00.0The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. E S REYNOLDSJ. Cell Biol.196313986422Yes
182678713393.51629.9815.0Statistical methods for assessing agreement between two methods of clinical measurement. J M Bland, D G AltmanLancet19862868172Yes
191323513235.0405.1405.1Atherosclerosis--an inflammatory disease. R RossN. Engl. J. Med.19999887164No
201248312483.0558.66558.7A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. M KimuraJ. Mol. Evol.19807463489Yes
211245512455.00.00.0Tissue sulfhydryl groups. G L ELLMANArch. Biochem. Biophys.195913650640Yes
223684412281.31258.16419.4CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. J D Thompson, D G Higgins, T J GibsonNucleic Acids Res.19947984417Yes
232455912279.50.00.0The measurement of observer agreement for categorical data. J R Landis, G G KochBiometrics1977843571Yes
242427212136.01006.78503.4Hallmarks of cancer: the next generation. Douglas Hanahan, Robert A WeinbergCell201121376230No
251202312023.0536.74536.7Density-functional exchange-energy approximation with correct asymptotic behavior. BeckePhys Rev A Gen Phys19889900728Yes
263493711645.70.00.0Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. H Towbin, T Staehelin, J GordonProc. Natl. Acad. Sci. U.S.A.1979388439Yes
271161411614.0442.4442.4CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP. Joseph FelsensteinEvolution198528561359Yes
281159211592.00.00.0High resolution two-dimensional electrophoresis of proteins. P H O'FarrellJ. Biol. Chem.1975236308Yes
291098610986.0332.77332.8MicroRNAs: target recognition and regulatory functions. David P BartelCell200919167326No
302136110680.50.00.0A rapid method of total lipid extraction and purification. E G BLIGH, W J DYERCan J Biochem Physiol195913671378Yes
311036910369.0552.05552.0A power primer. J CohenPsychol Bull199219565683Yes
321021610216.00.00.0DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS. B J DAVISAnn. N. Y. Acad. Sci.196414240539Yes
332031310156.5936.93468.5Meta-analysis in clinical trials. R DerSimonian, N LairdControl Clin Trials19863802833Yes
34195519775.51012.57506.3The hospital anxiety and depression scale. A S Zigmond, R P SnaithActa Psychiatr Scand19836880820Yes
3597069706.00.00.0A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. K BURTONBiochem. J.195613293190Yes
36289039634.30.00.0A simple method for the isolation and purification of total lipides from animal tissues. J FOLCH, M LEES, G H SLOANE STANLEYJ. Biol. Chem.195713428781Yes
3793039303.0307.15307.1Projector augmented-wave method. BlöchlPhys. Rev., B Condens. Matter19949976227Yes
38184569228.01019.17509.6The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. J E Ware, C D SherbourneMed Care19921593914Yes
3992239223.0445.99446.0Structure validation in chemical crystallography. Anthony L SpekActa Crystallogr. D Biol. Crystallogr.200919171970Yes
40181079053.5440.82220.4Coot: model-building tools for molecular graphics. Paul Emsley, Kevin CowtanActa Crystallogr. D Biol. Crystallogr.200415572765Yes
41429728594.41465.14293.0Basic local alignment search tool. S F Altschul, W Gish, W Miller, E W Myers, D J LipmanJ. Mol. Biol.19902231712Yes
4285918591.0428.58428.6Catalase in vitro. H AebiMeth. Enzymol.19846727660Yes
4385108510.00.00.0The genetics of Caenorhabditis elegans. S BrennerGenetics19744366476Yes
4483718371.00.00.0Phosphorus assay in column chromatography. G R BARTLETTJ. Biol. Chem.195913641241Yes
45241788059.3863.31287.8Generalized Gradient Approximation Made Simple. Perdew, Burke, ErnzerhofPhys. Rev. Lett.199610062328Yes
4679597959.0274.57274.6The Psychophysics Toolbox. D H BrainardSpat Vis19979176952Yes
47157167858.0475.18237.6Fast and accurate short read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics200919451168Yes
48154987749.0580.81290.4A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. A P Feinberg, B VogelsteinAnal. Biochem.19836312838Yes
4976437643.0324.47324.5Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). J F KurtzkeNeurology19836685237Yes
50151587579.0373.89186.9[20] Processing of X-ray diffraction data collected in oscillation mode. Zbyszek Otwinowski, Wladek MinorMeth. Enzymol.199727799103Yes
5175087508.0248.55248.6XDS. Wolfgang KabschActa Crystallogr. D Biol. Crystallogr.201020124692Yes
5275007500.0264.31264.3Studies on transformation of Escherichia coli with plasmids. D HanahanJ. Mol. Biol.19836345791Yes
5374397439.0179.32179.3Mfold web server for nucleic acid folding and hybridization prediction. Michael ZukerNucleic Acids Res.200312824337Yes
5474037403.0170.01170.0Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Gordon K SmythStat Appl Genet Mol Biol200416646809Yes
5573857385.0308.28308.3Search and clustering orders of magnitude faster than BLAST. Robert C EdgarBioinformatics201020709691Yes
5673317331.00.00.0Self-efficacy: toward a unifying theory of behavioral change. A BanduraPsychol Rev1977847061Yes
57218627287.31001.12333.7Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. Lee, Yang, ParrPhys. Rev., B Condens. Matter19889944570Yes
58144857242.5796.02398.0The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. R M Baron, D A KennyJ Pers Soc Psychol19863806354Yes
5972147214.0218.56218.6RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. Alexandros StamatakisBioinformatics200616928733Yes
6070827082.0245.96246.0Evolutionary trees from DNA sequences: a maximum likelihood approach. J FelsensteinJ. Mol. Evol.19817288891Yes
6170727072.0473.07473.1RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Alexandros StamatakisBioinformatics201424451623Yes
62141297064.5344.28172.1The hallmarks of cancer. D Hanahan, R A WeinbergCell200010647931No
6370407040.0261.83261.8The pathogenesis of atherosclerosis: a perspective for the 1990s. R RossNature19938479518No
6470327032.0340.01340.0A new method for measuring daytime sleepiness: the Epworth sleepiness scale. M W JohnsSleep19911798888Yes
65139876993.5489.95245.0A simple method for displaying the hydropathic character of a protein. J Kyte, R F DoolittleJ. Mol. Biol.19827108955Yes
6667466746.00.00.0Improvements in epoxy resin embedding methods. J H LUFTJ Biophys Biochem Cytol196113764136Yes
6766696669.0245.04245.0Vitamin D deficiency. Michael F HolickN. Engl. J. Med.200717634462No
68131536576.5439.8219.9Quantifying heterogeneity in a meta-analysis. Julian P T Higgins, Simon G ThompsonStat Med200212111919Yes
6965156515.0220.73220.7Integrins: versatility, modulation, and signaling in cell adhesion. R O HynesCell19921555235No
70128636431.50.00.0The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. K Weber, M OsbornJ. Biol. Chem.19695806584Yes
71128406420.0545.44272.7Fast gapped-read alignment with Bowtie 2. Ben Langmead, Steven L SalzbergNat. Methods201222388286Yes
7263706370.0150.63150.6The functions of animal microRNAs. Victor AmbrosNature200415372042No
7363416341.0275.7275.7Banting lecture 1988. Role of insulin resistance in human disease. G M ReavenDiabetes19883056758No
7462866286.0365.93365.9Psychophysical bases of perceived exertion. G A BorgMed Sci Sports Exerc19827154893Yes
75124056202.5314.62157.3Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Kazutoshi Takahashi, Shinya YamanakaCell200616904174Yes
7661076107.0199.96200.0TreeView: an application to display phylogenetic trees on personal computers. R D PageComput. Appl. Biosci.19968902363Yes
7761006100.00.00.0On the origin of cancer cells. O WARBURGScience195613298683Yes
78121246062.0343.35171.7MrBayes 3: Bayesian phylogenetic inference under mixed models. Fredrik Ronquist, John P HuelsenbeckBioinformatics200312912839Yes
7960316031.00.00.0COPPER ENZYMES IN ISOLATED CHLOROPLASTS. POLYPHENOLOXIDASE IN BETA VULGARIS. D I ArnonPlant Physiol.194916654194Yes
8060266026.0187.34187.3Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. M C HochbergArthritis Rheum.19979324032Yes
81420086001.11255.48179.4Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. S F Altschul, T L Madden, A A Schäffer, J Zhang, Z Zhang, W Miller, D J LipmanNucleic Acids Res.19979254694No
82119305965.0381.74190.9Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set. Kresse, FurthmüllerPhys. Rev., B Condens. Matter19969984901Yes
8359605960.0182.21182.2Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. F TajimaGenetics19892513255Yes
84238155953.8853.81213.5Measuring inconsistency in meta-analyses. Julian P T Higgins, Simon G Thompson, Jonathan J Deeks, Douglas G AltmanBMJ200312958120No
85174295809.7544.33181.4Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Da Wei Huang, Brad T Sherman, Richard A LempickiNat Protoc200919131956Yes
8658055805.0242.46242.5Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. P S ThomasProc. Natl. Acad. Sci. U.S.A.19806159641Yes
8757525752.0196.38196.4Semiempirical GGA-type density functional constructed with a long-range dispersion correction. Stefan GrimmeJ Comput Chem200616955487Yes
8857515751.0196.96197.0AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. R W CoxComput. Biomed. Res.19968812068Yes
89172455748.3505.69168.6VMD: visual molecular dynamics. W Humphrey, A Dalke, K SchultenJ Mol Graph19968744570Yes
9057005700.0562.06562.1Crystal structure refinement with SHELXL. George M SheldrickActa Crystallogr C Struct Chem201525567568Yes
9156875687.0141.13141.1Chromatin modifications and their function. Tony KouzaridesCell200717320507No
92113395669.5275.43137.7Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. S J Clough, A F BentPlant J.199810069079Yes
93225125628.01038.82259.7A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. M E Charlson, P Pompei, K L Ales, C R MacKenzieJ Chronic Dis19873558716Yes
9455675567.0222.28222.3"Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. W N BurnetteAnal. Biochem.19816266278Yes
9555155515.0156.51156.5PAML 4: phylogenetic analysis by maximum likelihood. Ziheng YangMol. Biol. Evol.200717483113Yes
9654915491.00.00.0A simplification of the protein assay method of Lowry et al. which is more generally applicable. G L PetersonAnal. Biochem.1977603028Yes
9754065406.00.00.0Solvent content of protein crystals. B W MatthewsJ. Mol. Biol.19685700707Yes
98106855342.5413.52206.8Sequencing end-labeled DNA with base-specific chemical cleavages. A M Maxam, W GilbertMeth. Enzymol.19806246368Yes
9953315331.0157.16157.2Fast robust automated brain extraction. Stephen M SmithHum Brain Mapp200212391568No
100212885322.0833.43208.4Bias in meta-analysis detected by a simple, graphical test. M Egger, G Davey Smith, M Schneider, C MinderBMJ19979310563Yes
10152795279.0183.56183.6The VideoToolbox software for visual psychophysics: transforming numbers into movies. D G PelliSpat Vis19979176953Yes
102104585229.0330.61165.3Analyzing real-time PCR data by the comparative C(T) method. Thomas D Schmittgen, Kenneth J LivakNat Protoc200818546601Yes
103156855228.30.00.0Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. W T Friedewald, R I Levy, D S FredricksonClin. Chem.19724337382Yes
10451945194.00.00.0A low-viscosity epoxy resin embedding medium for electron microscopy. A R SpurrJ. Ultrastruct. Res.19694887011Yes
10551635163.0217.13217.1Ethical guidelines for investigations of experimental pain in conscious animals. M ZimmermannPain19836877845No
106152635087.7579.2193.1A new generation of Ca2+ indicators with greatly improved fluorescence properties. G Grynkiewicz, M Poenie, R Y TsienJ. Biol. Chem.19853838314Yes
10750405040.00.00.0Evaluation of survival data and two new rank order statistics arising in its consideration. N MantelCancer Chemother Rep19665910392Yes
10849774977.0308.55308.6Comparative fit indexes in structural models. P M BentlerPsychol Bull19902320703Yes
10949674967.0204.34204.3The role of protein kinase C in cell surface signal transduction and tumour promotion. Y NishizukaNature19846232463No
11049104910.0165.64165.6Canonical dynamics: Equilibrium phase-space distributions. HooverPhys Rev A Gen Phys19859895674Yes
11148904890.0112.16112.2Integrins: bidirectional, allosteric signaling machines. Richard O HynesCell200212297042No
11297284864.00.00.0A rapid alkaline extraction procedure for screening recombinant plasmid DNA. H C Birnboim, J DolyNucleic Acids Res.1979388356Yes
11348364836.0152.42152.4Angiogenesis in cancer, vascular, rheumatoid and other disease. J FolkmanNat. Med.19957584949No
11448144814.0209.65209.7Density-functional approximation for the correlation energy of the inhomogeneous electron gas. PerdewPhys. Rev., B Condens. Matter19869938299Yes
11548094809.0125.76125.8Inflammation in atherosclerosis. Peter LibbyNature200212490960No
11647944794.00.00.0Tumor angiogenesis: therapeutic implications. J FolkmanN. Engl. J. Med.19714938153No
11747424742.0118.7118.7p53, the cellular gatekeeper for growth and division. A J LevineCell19979039259No
118141984732.7655.59218.5NIH Image to ImageJ: 25 years of image analysis. Caroline A Schneider, Wayne S Rasband, Kevin W EliceiriNat. Methods201222930834No
11947264726.00.00.0Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. J R VaneNature New Biol.19715284360Yes
12047244724.0188.01188.0The blockade of immune checkpoints in cancer immunotherapy. Drew M PardollNat. Rev. Cancer201222437870No
12146864686.0133.71133.7Inflammation, atherosclerosis, and coronary artery disease. Göran K HanssonN. Engl. J. Med.200515843671No
12293034651.5307.86153.9MODELTEST: testing the model of DNA substitution. D Posada, K A CrandallBioinformatics19989918953Yes
12346504650.0185.95185.9The Clinical Dementia Rating (CDR): current version and scoring rules. J C MorrisNeurology19938232972Yes
12492984649.00.00.0Intraclass correlations: uses in assessing rater reliability. P E Shrout, J L FleissPsychol Bull197918839484No
12592324616.0249.25124.6A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Stéphane Guindon, Olivier GascuelSyst. Biol.200314530136Yes
12646134613.00.00.0Development of a rating scale for primary depressive illness. M HamiltonBr J Soc Clin Psychol19676080235Yes
12746064606.0130.88130.9Biochemistry and molecular cell biology of diabetic complications. M BrownleeNature200111742414Yes
12891904595.0258.6129.3MRBAYES: Bayesian inference of phylogenetic trees. J P Huelsenbeck, F RonquistBioinformatics200111524383Yes
12991894594.5236.55118.3Dendritic cells and the control of immunity. J Banchereau, R M SteinmanNature19989521319No
13091064553.00.00.0Statistical aspects of the analysis of data from retrospective studies of disease. N MANTEL, W HAENSZELJ. Natl. Cancer Inst.195913655060Yes
13145444544.0137.19137.2Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. T A SpringerCell19947507411No
132226944538.8721.6144.3The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. J D Thompson, T J Gibson, F Plewniak, F Jeanmougin, D G HigginsNucleic Acids Res.19979396791Yes
13390264513.00.00.0Prediction of creatinine clearance from serum creatinine. D W Cockcroft, M H GaultNephron19761244564Yes
13490164508.0208.87104.4KEGG: kyoto encyclopedia of genes and genomes. M Kanehisa, S GotoNucleic Acids Res.200010592173Yes
13544864486.0146.32146.3Inositol trisphosphate and calcium signalling. M J BerridgeNature19938381210No
13644804480.092.1992.2BLAT--the BLAST-like alignment tool. W James KentGenome Res.200211932250Yes
13789234461.50.00.0Continuous cultures of fused cells secreting antibody of predefined specificity. G Köhler, C MilsteinNature19751172191Yes
13844304430.0159.31159.3The steroid and thyroid hormone receptor superfamily. R M EvansScience19883283939No
13944284428.00.00.0The assessment of anxiety states by rating. M HAMILTONBr J Med Psychol195913638508Yes
14088544427.0399.39199.7The meaning and use of the area under a receiver operating characteristic (ROC) curve. J A Hanley, B J McNeilRadiology19827063747Yes
14144134413.0125.83125.8Free radicals in the physiological control of cell function. Wulf DrögePhysiol. Rev.200211773609No
14287634381.5223.53111.8One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. K A Datsenko, B L WannerProc. Natl. Acad. Sci. U.S.A.200010829079Yes
14387594379.50.00.0Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Y Cheng, W H PrusoffBiochem. Pharmacol.19734202581Yes
14443624362.0137.76137.8Apoptosis: a review of programmed cell death. Susan ElmoreToxicol Pathol200717562483No
14543564356.00.00.0Modification of seizure activity by electrical stimulation. II. Motor seizure. R J RacineElectroencephalogr Clin Neurophysiol19724110397Yes
14643194319.0120.17120.2Rapid and efficient site-specific mutagenesis without phenotypic selection. T A KunkelProc. Natl. Acad. Sci. U.S.A.19853881765Yes
14743014301.0169.23169.2jModelTest: phylogenetic model averaging. David PosadaMol. Biol. Evol.200818397919Yes
14842864286.0199.81199.8Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Andreas StangEur. J. Epidemiol.201020652370Yes
149170914272.8619.2154.8MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Koichiro Tamura, Joel Dudley, Masatoshi Nei, Sudhir KumarMol. Biol. Evol.200717488738Yes
15042464246.0150.57150.6Adhesion receptors of the immune system. T A SpringerNature19901974032No
15142304230.00.00.0The thiobarbituric acid assay of sialic acids. L WARRENJ. Biol. Chem.195913672998Yes
15242264226.00.00.0Selective extraction of polyoma DNA from infected mouse cell cultures. B HirtJ. Mol. Biol.19674291934Yes
15342034203.00.00.0Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. A BöyumScand. J. Clin. Lab. Invest. Suppl.19684179068Yes
154167674191.8849.8212.4Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanPLoS Med.200919621072No
15583724186.0215.93108.0Primer3 on the WWW for general users and for biologist programmers. S Rozen, H SkaletskyMethods Mol. Biol.200010547847Yes
15641834183.0130.93130.9Apoptosis in the pathogenesis and treatment of disease. C B ThompsonScience19957878464No
15741784178.0120.98121.0The NF-kappa B and I kappa B proteins: new discoveries and insights. A S BaldwinAnnu. Rev. Immunol.19968717528No
15841714171.0109.15109.2The biochemistry of apoptosis. M O HengartnerNature200011048727No
15941304130.094.3494.3Rho GTPases and the actin cytoskeleton. A HallScience19989438836No
16041294129.0114.52114.5Antimicrobial peptides of multicellular organisms. Michael ZasloffNature200211807545Yes
16141264126.0117.9117.9Inflammation and metabolic disorders. Gökhan S HotamisligilNature200617167474No
16241254125.091.1491.1Epithelial-mesenchymal transitions in tumour progression. Jean Paul ThieryNat. Rev. Cancer200212189386No
163164224105.50.00.0Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. J M Chirgwin, A E Przybyla, R J MacDonald, W J RutterBiochemistry1979518835Yes
16481844092.0243.08121.5Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. W Kabsch, C SanderBiopolymers19836667333Yes
16540864086.0179.77179.8The Strengths and Difficulties Questionnaire: a research note. R GoodmanJ Child Psychol Psychiatry19979255702Yes
166122534084.3473.22157.7A simple salting out procedure for extracting DNA from human nucleated cells. S A Miller, D D Dykes, H F PoleskyNucleic Acids Res.19883344216Yes
16740484048.0103.9103.9Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. J CastresanaMol. Biol. Evol.200010742046Yes
168121174039.00.00.0Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. H Ohkawa, N Ohishi, K YagiAnal. Biochem.197936810Yes
16940054005.00.00.0THE ENVIRONMENT AND DISEASE: ASSOCIATION OR CAUSATION? A B HILLProc. R. Soc. Med.196514283879Yes
17039913991.00.00.0Aging: a theory based on free radical and radiation chemistry. D HARMANJ Gerontol195613332224Yes
17139813981.0115.73115.7Emotion circuits in the brain. J E LeDouxAnnu. Rev. Neurosci.200010845062No
17239373937.00.00.0Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. F TietzeAnal. Biochem.19694388022Yes
173117583919.3439.66146.6Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. C Yanisch-Perron, J Vieira, J MessingGene19852985470Yes
17478243912.00.00.0A series of normal stages in the development of the chick embryo. V HAMBURGER, H L HAMILTONJ. Morphol.195124539719Yes
17577943897.0217.15108.6Comparative protein modelling by satisfaction of spatial restraints. A Sali, T L BlundellJ. Mol. Biol.19938254673Yes
17638933893.0143.76143.8New M13 vectors for cloning. J MessingMeth. Enzymol.19836310323Yes
17738863886.0128.97129.0G proteins: transducers of receptor-generated signals. A G GilmanAnnu. Rev. Biochem.19873113327No
17838833883.0145.62145.6Developments of a water-maze procedure for studying spatial learning in the rat. R MorrisJ. Neurosci. Methods19846471907Yes
179116053868.3325.44108.5Inference of population structure using multilocus genotype data. J K Pritchard, M Stephens, P DonnellyGenetics200010835412Yes
18038453845.00.00.0A SELF-RATING DEPRESSION SCALE. W W ZUNGArch. Gen. Psychiatry196514221692Yes
18176803840.0273.86136.9Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. H Schägger, G von JagowAnal. Biochem.19872449095Yes
18275753787.5303.77151.9Operating characteristics of a rank correlation test for publication bias. C B Begg, M MazumdarBiometrics19947786990Yes
18337683768.073.8673.9Generalized lacZ expression with the ROSA26 Cre reporter strain. P SorianoNat. Genet.19999916792Yes
18437553755.0181.94181.9Orienting of attention. M I PosnerQ J Exp Psychol19807367577Yes
185112493749.7439.45146.5Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Daniel Dindo, Nicolas Demartines, Pierre-Alain ClavienAnn. Surg.200415273542Yes
186224423740.31129.73188.3MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Koichiro Tamura, Daniel Peterson, Nicholas Peterson, Glen Stecher, Masatoshi Nei, Sudhir KumarMol. Biol. Evol.201121546353Yes
187112053735.0276.5792.2Refinement of macromolecular structures by the maximum-likelihood method. G N Murshudov, A A Vagin, E J DodsonActa Crystallogr. D Biol. Crystallogr.199715299926Yes
188111713723.7607.12202.4Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Michael I Love, Wolfgang Huber, Simon AndersGenome Biol.201425516281Yes
18937183718.0123.0123.0A modified poisson regression approach to prospective studies with binary data. Guangyong ZouAm. J. Epidemiol.200415033648Yes
19074153707.50.00.0A quantitative description of membrane current and its application to conduction and excitation in nerve. A L HODGKIN, A F HUXLEYJ. Physiol. (Lond.)195212991237Yes
191221423690.31062.01177.0Global cancer statistics. Ahmedin Jemal, Freddie Bray, Melissa M Center, Jacques Ferlay, Elizabeth Ward, David FormanCA Cancer J Clin201121296855Yes
19273743687.0242.64121.3Neuropathological stageing of Alzheimer-related changes. H Braak, E BraakActa Neuropathol.19911759558No
19336863686.0101.31101.3An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. M KozakNucleic Acids Res.19873313277No
19436673667.076.1476.1DNA methylation patterns and epigenetic memory. Adrian BirdGenes Dev.200211782440No
19536623662.086.4486.4Targeting HIF-1 for cancer therapy. Gregg L SemenzaNat. Rev. Cancer200313130303No
19636543654.092.8992.9MUSCLE: a multiple sequence alignment method with reduced time and space complexity. Robert C EdgarBMC Bioinformatics200415318951Yes
19736323632.00.00.0Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. M M MesulamJ. Histochem. Cytochem.197824068Yes
19872593629.50.00.0THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE. T OMURA, R SATOJ. Biol. Chem.196414209971Yes
19972363618.0405.01202.5MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Kazutaka Katoh, Daron M StandleyMol. Biol. Evol.201323329690Yes
20072003600.0183.3591.7The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. John Hardy, Dennis J SelkoeScience200212130773No
20171983599.0178.3289.2Inflammation and cancer. Lisa M Coussens, Zena WerbNature200212490959No
20271953597.50.00.0Assessment of older people: self-maintaining and instrumental activities of daily living. M P Lawton, E M BrodyGerontologist19695349366Yes
203179363587.21167.92233.6MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir KumarMol. Biol. Evol.201324132122Yes
20435643564.00.00.0Preparation of isolated rat liver cells. P O SeglenMethods Cell Biol.1976177845No
20535633563.0117.47117.5The Cambridge Structural Database: a quarter of a million crystal structures and rising. Frank H AllenActa Crystallogr., B200212037359Yes
20671173558.5313.39156.7Three approaches to qualitative content analysis. Hsiu-Fang Hsieh, Sarah E ShannonQual Health Res200516204405Yes
207106633554.3383.59127.9A comprehensive set of sequence analysis programs for the VAX. J Devereux, P Haeberli, O SmithiesNucleic Acids Res.19846546423Yes
208106283542.7640.08213.4Trimmomatic: a flexible trimmer for Illumina sequence data. Anthony M Bolger, Marc Lohse, Bjoern UsadelBioinformatics201424695404Yes
20935403540.0120.69120.7A fast diffeomorphic image registration algorithm. John AshburnerNeuroimage200717761438Yes
21035343534.090.5190.5Prions. S B PrusinerProc. Natl. Acad. Sci. U.S.A.19989811807No
21135163516.0179.23179.2Oxygen-derived free radicals in postischemic tissue injury. J M McCordN. Engl. J. Med.19852981404No
21235083508.0181.79181.8Revisiting the behavioral model and access to medical care: does it matter? R M AndersenJ Health Soc Behav19957738325Yes
21370113505.5344.79172.4The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. R F Furchgott, J V ZawadzkiNature19806253831Yes
21434903490.00.00.0The McGill Pain Questionnaire: major properties and scoring methods. R MelzackPain19751235985Yes
21534853485.00.00.0Mutation and cancer: statistical study of retinoblastoma. A G KnudsonProc. Natl. Acad. Sci. U.S.A.19715279523Yes
216104523484.0484.74161.6The positive and negative syndrome scale (PANSS) for schizophrenia. S R Kay, A Fiszbein, L A OplerSchizophr Bull19873616518Yes
21769453472.5186.6693.3SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling. N Guex, M C PeitschElectrophoresis19979504803Yes
21869423471.0234.24117.1Improved tools for biological sequence comparison. W R Pearson, D J LipmanProc. Natl. Acad. Sci. U.S.A.19883162770Yes
21934713471.0207.08207.1Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Y KandaBone Marrow Transplant.201323208313Yes
220104053468.3338.17112.7edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Mark D Robinson, Davis J McCarthy, Gordon K SmythBioinformatics201019910308Yes
22169203460.0226.43113.2A synaptic model of memory: long-term potentiation in the hippocampus. T V Bliss, G L CollingridgeNature19938421494No
22234563456.082.5182.5Alternative activation of macrophages. Siamon GordonNat. Rev. Immunol.200312511873No
223103473449.01220.55406.8MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Sudhir Kumar, Glen Stecher, Koichiro TamuraMol. Biol. Evol.201627004904Yes
22468923446.00.00.0A new technique for the assay of infectivity of human adenovirus 5 DNA. F L Graham, A J van der EbVirology19734705382Yes
22534463446.00.00.0Index for rating diagnostic tests. W J YOUDENCancer195015405679Yes
22634433443.088.7288.7Alzheimer's disease: genes, proteins, and therapy. D J SelkoePhysiol. Rev.200111274343No
22734343434.00.00.0The genetical evolution of social behaviour. I. W D HamiltonJ. Theor. Biol.19645875341Yes
22834263426.087.4787.5Cancer cell cycles. C J SherrScience19968939849No
22968503425.00.00.0FUNCTIONAL EVALUATION: THE BARTHEL INDEX. F I MAHONEY, D W BARTHELMd State Med J196514258950Yes
23068463423.0227.63113.8The rise of graphene. A K Geim, K S NovoselovNat Mater200717330084Yes
23168433421.5215.01107.5Differential expression analysis for sequence count data. Simon Anders, Wolfgang HuberGenome Biol.201020979621Yes
23234063406.094.294.2Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. M KozakCell19863943125Yes
23368053402.50.00.0A new depression scale designed to be sensitive to change. S A Montgomery, M AsbergBr J Psychiatry1979444788Yes
23433763376.0110.2110.2Mild cognitive impairment as a diagnostic entity. R C PetersenJ. Intern. Med.200415324362No
23533733373.082.9683.0PAML: a program package for phylogenetic analysis by maximum likelihood. Z YangComput. Appl. Biosci.19979367129Yes
236101193373.0381.06127.0The PHQ-9: validity of a brief depression severity measure. K Kroenke, R L Spitzer, J B WilliamsJ Gen Intern Med200111556941Yes
237168633372.60.00.0An inventory for measuring depression. A T BECK, C H WARD, M MENDELSON, J MOCK, J ERBAUGHArch. Gen. Psychiatry196113688369Yes
238100733357.7543.81181.3Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. S M Hsu, L Raine, H FangerJ. Histochem. Cytochem.19816166661Yes
23933503350.082.382.3Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. C J MarshallCell19957834738No
24033453345.0115.77115.8A new method for predicting signal sequence cleavage sites. G von HeijneNucleic Acids Res.19863714490Yes
24133423342.0140.65140.7Studies and perspectives of protein kinase C. Y NishizukaScience19863014651No
24233363336.00.00.0The detection of disease clustering and a generalized regression approach. N MantelCancer Res.19676018555Yes
24399683322.7470.81156.9Nitric oxide: physiology, pathophysiology, and pharmacology. S Moncada, R M Palmer, E A HiggsPharmacol. Rev.19911852778No
24466433321.5152.8976.4A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. R S Sikorski, P HieterGenetics19892659436Yes
24566153307.5217.96109.0EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Arnaud Delorme, Scott MakeigJ. Neurosci. Methods200415102499Yes
24633023302.072.1172.1The phosphoinositide 3-kinase pathway. Lewis C CantleyScience200212040186No
24765803290.0148.674.3 Processing of X-ray diffraction data collected in oscillation mode. Z Otwinowski, W MinorMeth. Enzymol.199727754618Yes
24832853285.00.00.0Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. W H HarrisJ Bone Joint Surg Am19695783851Yes
24932793279.077.0777.1Wnt/beta-catenin signaling in development and disease. Hans CleversCell200617081971No
25065213260.5187.3193.7BEDTools: a flexible suite of utilities for comparing genomic features. Aaron R Quinlan, Ira M HallBioinformatics201020110278Yes
25132523252.00.00.0THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION. P LAURENActa Pathol Microbiol Scand196514320675Yes
25265023251.0191.9996.0A genetic model for colorectal tumorigenesis. E R Fearon, B VogelsteinCell19902188735No
25332333233.00.00.0Estimation of nuclear population from microtome sections. M ABERCROMBIEAnat. Rec.194621015608Yes
25464653232.50.00.0Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J M McCord, I FridovichJ. Biol. Chem.19695389100Yes
25564633231.5170.2685.1Collective dynamics of 'small-world' networks. D J Watts, S H StrogatzNature19989623998Yes
25632203220.0129.49129.5Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. P MatsudairaJ. Biol. Chem.19873611052Yes
25732193219.00.00.0The clonal evolution of tumor cell populations. P C NowellScience1976959840Yes
25864363218.00.00.0A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. W M Bonner, R A LaskeyEur. J. Biochem.19744850204Yes
25932153215.090.3990.4ras oncogenes in human cancer: a review. J L BosCancer Res.19892547513No
26032103210.087.4787.5Mechanisms of angiogenesis. W RisauNature19979109485No
26131863186.0103.84103.8Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing. S HenikoffGene19846235151Yes
26231733173.084.4484.4Apoptosis by death factor. S NagataCell19979039262No
26331653165.0197.08197.1UPARSE: highly accurate OTU sequences from microbial amplicon reads. Robert C EdgarNat. Methods201323955772Yes
26463143157.0130.5565.3Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. A H Brand, N PerrimonDevelopment19938223268Yes
26531423142.00.00.0THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. L HAYFLICKExp. Cell Res.196514315085Yes
26662673133.5343.39171.7Ligand: a versatile computerized approach for characterization of ligand-binding systems. P J Munson, D RodbardAnal. Biochem.19806254391Yes
267125293132.2403.28100.8Global cancer statistics, 2002. D Max Parkin, Freddie Bray, J Ferlay, Paola PisaniCA Cancer J Clin200515761078Yes
26831183118.0152.72152.7The pathogenesis of atherosclerosis--an update. R RossN. Engl. J. Med.19863511384No
26931093109.0223.91223.9Prokka: rapid prokaryotic genome annotation. Torsten SeemannBioinformatics201424642063Yes
27031083108.0100.41100.4Sequencing technologies - the next generation. Michael L MetzkerNat. Rev. Genet.201019997069No
27131033103.073.9574.0The retinoblastoma protein and cell cycle control. R A WeinbergCell19957736585No
27231013101.0122.65122.7Glutamate neurotoxicity and diseases of the nervous system. D W ChoiNeuron19882908446No
27331013101.094.9494.9Staphylococcus aureus infections. F D LowyN. Engl. J. Med.19989709046No
27430893089.0138.85138.8Whatever happened to qualitative description? M SandelowskiRes Nurs Health200010940958No
27530873087.00.00.0Evolution in Mendelian Populations. S WrightGenetics193117246615Yes
27630843084.099.7299.7Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. R B D'AgostinoStat Med19989802183Yes
27730723072.0105.98106.0Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Y NishizukaScience19921411571No
27861413070.50.00.0Parkinsonism: onset, progression and mortality. M M Hoehn, M D YahrNeurology19676067254Yes
27991923064.0973.14324.4Cancer statistics, 2016. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201626742998Yes
28061173058.5242.19121.1DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. P Librado, J RozasBioinformatics200919346325Yes
281183413056.8754.91125.8Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. D R Matthews, J P Hosker, A S Rudenski, B A Naylor, D F Treacher, R C TurnerDiabetologia19853899825Yes
28230553055.0143.14143.1EuroQol: the current state of play. R BrooksHealth Policy199610158943No
28330483048.070.8370.8Protein secondary structure prediction based on position-specific scoring matrices. D T JonesJ. Mol. Biol.199910493868Yes
28430453045.092.2792.3Multiple sequence alignment with hierarchical clustering. F CorpetNucleic Acids Res.19882849754Yes
28530423042.0103.35103.3Revisions in the International System for Staging Lung Cancer. C F MountainChest19979187198Yes
28660703035.0207.45103.7BEAST: Bayesian evolutionary analysis by sampling trees. Alexei J Drummond, Andrew RambautBMC Evol. Biol.200717996036Yes
28730323032.00.00.0Bone: formation by autoinduction. M R UristScience19655319761Yes
28830203020.076.8676.9Atherosclerosis. A J LusisNature200011001066No
28930163016.090.5490.5The dendritic cell system and its role in immunogenicity. R M SteinmanAnnu. Rev. Immunol.19911910679No
29030133013.082.0782.1Marrow stromal cells as stem cells for nonhematopoietic tissues. D J ProckopScience19979082988No
29130003000.0103.46103.5How mitochondria produce reactive oxygen species. Michael P MurphyBiochem. J.200919061483No
29289882996.0232.2677.4Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. J D Dignam, R M Lebovitz, R G RoederNucleic Acids Res.19836828386Yes
29329942994.070.6670.7The green fluorescent protein. R Y TsienAnnu. Rev. Biochem.19989759496No
29429862986.073.573.5Tandem repeats finder: a program to analyze DNA sequences. G BensonNucleic Acids Res.19999862982Yes
29529792979.0120.13120.1Bacterial evolution. C R WoeseMicrobiol. Rev.19872439888No
29629692969.00.00.0A rapid banding technique for human chromosomes. M SeabrightLancet19714107917Yes
29729612961.00.00.0The need for a new medical model: a challenge for biomedicine. G L EngelScience1977847460Yes
29859072953.50.00.0Assessment of coma and impaired consciousness. A practical scale. G Teasdale, B JennettLancet19744136544Yes
29988602953.3514.63171.5Cancer statistics, 2013. Rebecca Siegel, Deepa Naishadham, Ahmedin JemalCA Cancer J Clin201323335087Yes
30029422942.074.8174.8Scaling and assessment of data quality. Philip EvansActa Crystallogr. D Biol. Crystallogr.200616369096No
30129352935.00.00.0Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. C B LaurellAnal. Biochem.19665959431Yes
30229352935.080.7980.8Nonalcoholic fatty liver disease. Paul AnguloN. Engl. J. Med.200211961152No
30329342934.00.00.0A membrane-filter technique for the detection of complementary DNA. D T DenhardtBiochem. Biophys. Res. Commun.19665963888Yes
304117302932.50.00.0A new and rapid colorimetric determination of acetylcholinesterase activity. G L ELLMAN, K D COURTNEY, V ANDRES, R M FEATHER-STONEBiochem. Pharmacol.196113726518Yes
30529182918.00.00.0METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS. M RODBELLJ. Biol. Chem.196414169133Yes
30629122912.069.1969.2TGF-beta signal transduction. J MassaguéAnnu. Rev. Biochem.19989759503No
30758092904.5162.5881.3tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. T M Lowe, S R EddyNucleic Acids Res.19979023104Yes
30858082904.0173.8986.9Genomic sequencing. G M Church, W GilbertProc. Natl. Acad. Sci. U.S.A.19846326095Yes
30986532884.3466.88155.6Development and validation of brief measures of positive and negative affect: the PANAS scales. D Watson, L A Clark, A TellegenJ Pers Soc Psychol19883397865Yes
31057622881.0146.7773.4Functional rafts in cell membranes. K Simons, E IkonenNature19979177342No
31157612880.5168.9384.5Mitochondria and apoptosis. D R Green, J C ReedScience19989721092No
31228782878.0111.96112.0genepop'007: a complete re-implementation of the genepop software for Windows and Linux. François RoussetMol Ecol Resour200821585727Yes
31328762876.065.2865.3Mammalian neural stem cells. F H GageScience200010688783No
31428692869.075.375.3Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Rakesh K JainScience200515637262No
31528682868.072.6572.7Protein production by auto-induction in high density shaking cultures. F William StudierProtein Expr. Purif.200515915565Yes
31685892863.00.00.0Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. W H Habig, M J Pabst, W B JakobyJ. Biol. Chem.19744436300Yes
31728602860.068.8468.8Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. G R MartinProc. Natl. Acad. Sci. U.S.A.19816950406Yes
31828562856.0104.03104.0The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Y NishizukaNature19883045562No
31928552855.0111.14111.1Updating P300: an integrative theory of P3a and P3b. John PolichClin Neurophysiol200717573239No
32028482848.081.5881.6Cancer. p53, guardian of the genome. D P LaneNature19921614522No
32128462846.00.00.0Transformed up-down methods in psychoacoustics. H LevittJ. Acoust. Soc. Am.19715541744Yes
32228462846.078.0278.0Why most published research findings are false. John P A IoannidisPLoS Med.200516060722Yes
32328352835.00.00.0Determination of protein: a modification of the Lowry method that gives a linear photometric response. E F HartreeAnal. Biochem.19724115981Yes
32456492824.5227.19113.6AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Oleg Trott, Arthur J OlsonJ Comput Chem201019499576Yes
32528232823.065.0465.0Hypoxia--a key regulatory factor in tumour growth. Adrian L HarrisNat. Rev. Cancer200211902584No
32628222822.086.1986.2Microglia: a sensor for pathological events in the CNS. G W KreutzbergTrends Neurosci.19968843599No
32784542818.0409.53136.5A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. J Ware, M Kosinski, S D KellerMed Care19968628042Yes
32828142814.0135.94135.9A concordance correlation coefficient to evaluate reproducibility. L I LinBiometrics19892720055Yes
32928102810.061.1461.1Signal transduction by the JNK group of MAP kinases. R J DavisCell200011057897No
33056172808.5258.59129.3Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. U H Graneheim, B LundmanNurse Educ Today200414769454No
33156122806.0143.6571.8MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Jürgen Cox, Matthias MannNat. Biotechnol.200819029910Yes
33228042804.00.00.0A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. E PfeifferJ Am Geriatr Soc19751159263Yes
33328032803.0101.48101.5Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. A H WyllieNature19806245367Yes
33427832783.063.8563.9Profile hidden Markov models. S R EddyBioinformatics19989918945No
33555582779.0168.2184.1Control of goal-directed and stimulus-driven attention in the brain. Maurizio Corbetta, Gordon L ShulmanNat. Rev. Neurosci.200211994752No
336110852771.2371.2992.8Features and development of Coot. P Emsley, B Lohkamp, W G Scott, K CowtanActa Crystallogr. D Biol. Crystallogr.201020383002Yes
33727712771.097.2997.3What is the evidence that tumors are angiogenesis dependent? J FolkmanJ. Natl. Cancer Inst.19901688381No
33827642764.088.1288.1The adolescent brain and age-related behavioral manifestations. L P SpearNeurosci Biobehav Rev200010817843No
33927632763.0259.87259.9SHELXT - integrated space-group and crystal-structure determination. George M SheldrickActa Crystallogr A Found Adv201525537383Yes
34027602760.00.00.0Principles that govern the folding of protein chains. C B AnfinsenScience19734124164Yes
34155172758.5261.56130.8Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Kristopher J Preacher, Andrew F HayesBehav Res Methods200818697684Yes
34227582758.078.9879.0Caspases: the executioners of apoptosis. G M CohenBiochem. J.19979337844No
34327582758.00.00.0Amino acid metabolism in mammalian cell cultures. H EAGLEScience195913675766Yes
34427572757.0126.86126.9Measuring the accuracy of diagnostic systems. J A SwetsScience19883287615No
34555052752.5109.2654.6Translating the histone code. T Jenuwein, C D AllisScience200111498575No
34654962748.0182.6691.3Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Daniel R Zerbino, Ewan BirneyGenome Res.200818349386Yes
34727452745.083.4183.4A catalogue of splice junction sequences. S M MountNucleic Acids Res.19827063411Yes
34827452745.0111.2111.2Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Russell A BarkleyPsychol Bull19979000892No
34982272742.3427.39142.5Cancer statistics, 2012. Rebecca Siegel, Deepa Naishadham, Ahmedin JemalCA Cancer J Clin201222237781Yes
35027412741.00.00.0Generalized expectancies for internal versus external control of reinforcement. J B RotterPsychol Monogr19665340840No
35127382738.0119.75119.8ANALYZING TABLES OF STATISTICAL TESTS. William R RiceEvolution198928568501Yes
35227342734.00.00.0Estimation of average heterozygosity and genetic distance from a small number of individuals. M NeiGenetics197817248844Yes
35327252725.079.8479.8Novel proteinaceous infectious particles cause scrapie. S B PrusinerScience19826801762Yes
35481532717.7665.37221.8Cancer statistics, 2015. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201525559415Yes
35527172717.0121.09121.1Tissue destruction by neutrophils. S J WeissN. Engl. J. Med.19892536474No
35654222711.0121.5160.8Statistical significance for genomewide studies. John D Storey, Robert TibshiraniProc. Natl. Acad. Sci. U.S.A.200312883005Yes
35727102710.069.5669.6Instability and decay of the primary structure of DNA. T LindahlNature19938469282No
35827062706.074.6874.7Glutamate uptake. N C DanboltProg. Neurobiol.200111369436No
35927052705.0108.41108.4How do you feel--now? The anterior insula and human awareness. A D Bud CraigNat. Rev. Neurosci.200919096369No
36053932696.50.00.0Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. D E Paglia, W N ValentineJ. Lab. Clin. Med.19676066618Yes
36126952695.099.0799.1Protective and damaging effects of stress mediators. B S McEwenN. Engl. J. Med.19989428819No
36280802693.3315.26105.1Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. E R DeLong, D M DeLong, D L Clarke-PearsonBiometrics19883203132Yes
36326892689.096.196.1What's wrong with Bonferroni adjustments. T V PernegerBMJ19989553006No
36453762688.00.00.0Radiological assessment of osteo-arthrosis. J H KELLGREN, J S LAWRENCEAnn. Rheum. Dis.195713498604Yes
36553712685.50.00.0Microsomal lipid peroxidation. J A Buege, S D AustMeth. Enzymol.1978672633Yes
36626852685.078.678.6ras genes. M BarbacidAnnu. Rev. Biochem.19873304147No
36726732673.00.00.0New methods for calculating metabolic rate with special reference to protein metabolism. J B DE B WEIRJ. Physiol. (Lond.)194915394301Yes
368106862671.5300.8975.2Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Ben Langmead, Cole Trapnell, Mihai Pop, Steven L SalzbergGenome Biol.200919261174Yes
36980132671.00.00.0Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. J F Kerr, A H Wyllie, A R CurrieBr. J. Cancer19724561027No
37026702670.0130.03130.0An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies. Peter C AustinMultivariate Behav Res201121818162Yes
371133492669.8519.03103.8Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. O P Hamill, A Marty, E Neher, B Sakmann, F J SigworthPflugers Arch.19816270629Yes
37226652665.00.00.0The Scree Test For The Number Of Factors. R B CattellMultivariate Behav Res196626828106Yes
37326642664.00.00.0Aggregation of blood platelets by adenosine diphosphate and its reversal. G V BORNNature196213871375Yes
37426572657.096.3396.3Soft self-consistent pseudopotentials in a generalized eigenvalue formalism. VanderbiltPhys. Rev., B Condens. Matter19909993096Yes
37526552655.00.00.0The determination of enzyme inhibitor constants. M DIXONBiochem. J.195313093635Yes
37626512651.0107.47107.5Modeling valuations for EuroQol health states. P DolanMed Care19979366889Yes
377105902647.5434.28108.6G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel BuchnerBehav Res Methods200717695343Yes
37826402640.00.00.0Staining of tissue sections for electron microscopy with heavy metals. M L WATSONJ Biophys Biochem Cytol195813563554Yes
37952782639.0155.7677.9An integrative theory of prefrontal cortex function. E K Miller, J D CohenAnnu. Rev. Neurosci.200111283309No
38078672622.3177.3259.1Significance analysis of microarrays applied to the ionizing radiation response. V G Tusher, R Tibshirani, G ChuProc. Natl. Acad. Sci. U.S.A.200111309499Yes
38126192619.094.9194.9Graphene: status and prospects. A K GeimScience200919541989Yes
38226132613.095.2995.3Integrins: a family of cell surface receptors. R O HynesCell19873028640No
38326082608.00.00.0Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. J CohenPsychol Bull196819673146Yes
38426012601.096.5496.5Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. L R SquirePsychol Rev19921594723No
38525982598.0111.63111.6Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. J H MorrisseyAnal. Biochem.19816172996Yes
38625892589.092.3592.3Biological roles of oligosaccharides: all of the theories are correct. A VarkiGlycobiology19938490246No
38725812581.098.9899.0Development of a classification system for periodontal diseases and conditions. G C ArmitageAnn. Periodontol.199910863370No
38851512575.5108.2454.1The ubiquitin system. A Hershko, A CiechanoverAnnu. Rev. Biochem.19989759494No
38951492574.5273.35136.7The timed "Up & Go": a test of basic functional mobility for frail elderly persons. D Podsiadlo, S RichardsonJ Am Geriatr Soc19911991946Yes
39051492574.5169.884.9Ab initio molecular dynamics for liquid metals. Kresse, HafnerPhys. Rev., B Condens. Matter199310004490Yes
39177132571.01078.68359.6Cancer Statistics, 2017. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201728055103Yes
39225692569.070.7770.8The scanning model for translation: an update. M KozakJ. Cell Biol.19892645293No
39325682568.075.5175.5The basis of anisotropic water diffusion in the nervous system - a technical review. Christian BeaulieuNMR Biomed200212489094No
39425652565.00.00.0[A micro-method of immuno-electrophoresis]. J J SCHEIDEGGERInt. Arch. Allergy Appl. Immunol.195513262900Yes
39525582558.0107.74107.7Nitric oxide as a secretory product of mammalian cells. C NathanFASEB J.19921381691No
39625482548.062.9763.0Activators and target genes of Rel/NF-kappaB transcription factors. H L PahlOncogene199910602461No
39750892544.50.00.0Preparation of iodine-131 labelled human growth hormone of high specific activity. W M HUNTER, F C GREENWOODNature196214450081Yes
39825432543.077.8577.8The origins and the future of microfluidics. George M WhitesidesNature200616871203No
39925392539.00.00.0Basic principles of ROC analysis. C E MetzSemin Nucl Med1978112681Yes
40025362536.075.575.5I-TASSER server for protein 3D structure prediction. Yang ZhangBMC Bioinformatics200818215316Yes
40175942531.3179.4359.8Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Benjamin P Lewis, Christopher B Burge, David P BartelCell200515652477Yes
40275932531.00.00.0Determination of serum proteins by means of the biuret reaction. A G GORNALL, C J BARDAWILL, M M DAVIDJ. Biol. Chem.194918110453Yes
403101192529.8286.0571.5Haploview: analysis and visualization of LD and haplotype maps. J C Barrett, B Fry, J Maller, M J DalyBioinformatics200515297300Yes
40425292529.00.00.0Observational study of behavior: sampling methods. J AltmannBehaviour19744597405No
40525292529.057.7457.7STATs and gene regulation. J E DarnellScience19979287210No
40625292529.053.7753.8Cell signaling by receptor tyrosine kinases. J SchlessingerCell200011057895No
40775752525.0387.33129.1A global measure of perceived stress. S Cohen, T Kamarck, R MermelsteinJ Health Soc Behav19836668417Yes
40825232523.074.6774.7Oxidative stress, antioxidants and stress tolerance. Ron MittlerTrends Plant Sci.200212234732No
40925192519.060.0260.0Somatic generation of antibody diversity. S TonegawaNature19836300689No
41050202510.0169.0684.5Balanced basis sets of split valence, triple zeta valence and quadruple zeta valence quality for H to Rn: Design and assessment of accuracy. Florian Weigend, Reinhart AhlrichsPhys Chem Chem Phys200516240044Yes
41125062506.074.9274.9Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. A T BrüngerNature199218481394Yes
41224962496.074.1774.2Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. M KozakNucleic Acids Res.19846694911Yes
41324932493.0100.77100.8Emerging adulthood. A theory of development from the late teens through the twenties. J J ArnettAm Psychol200010842426Yes
41449812490.5222.03111.0Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Laurent Excoffier, Heidi E L LischerMol Ecol Resour201021565059Yes
41524892489.074.074.0Neural networks and physical systems with emergent collective computational abilities. J J HopfieldProc. Natl. Acad. Sci. U.S.A.19826953413Yes
41624782478.076.6376.6Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Kim A BrogdenNat. Rev. Microbiol.200515703760No
41724742474.068.8468.8Wound healing--aiming for perfect skin regeneration. P MartinScience19979082989No
41824722472.075.4275.4Biologic basis for interleukin-1 in disease. C A DinarelloBlood19968630372No
41924702470.00.00.0The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. T NASHBiochem. J.195313105648Yes
42024652465.071.4571.5WHAT IF: a molecular modeling and drug design program. G VriendJ Mol Graph19902268628Yes
42124552455.077.3577.3Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection. Y X FuGenetics19979335623Yes
42249022451.0132.3366.2Inference of macromolecular assemblies from crystalline state. Evgeny Krissinel, Kim HenrickJ. Mol. Biol.200717681537Yes
42348962448.0172.5186.3RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. Bo Li, Colin N DeweyBMC Bioinformatics201121816040Yes
42448882444.0151.7475.9The basics of epithelial-mesenchymal transition. Raghu Kalluri, Robert A WeinbergJ. Clin. Invest.200919487818No
42548782439.0120.1960.1Toll-like receptor signalling. Shizuo Akira, Kiyoshi TakedaNat. Rev. Immunol.200415229469No
42624352435.085.3185.3Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. R W MahleyScience19883283935No
42724282428.076.2476.2The heat-shock response. S LindquistAnnu. Rev. Biochem.19862427013No
42872792426.3223.6974.6MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Sudhir Kumar, Koichiro Tamura, Masatoshi NeiBrief. Bioinformatics200415260895Yes
42924242424.072.372.3How do you feel? Interoception: the sense of the physiological condition of the body. A D CraigNat. Rev. Neurosci.200212154366No
43024202420.064.1964.2Folding DNA to create nanoscale shapes and patterns. Paul W K RothemundNature200616541064Yes
43148332416.50.00.0Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. D H HUBEL, T N WIESELJ. Physiol. (Lond.)196214449617Yes
43224162416.078.3678.4Hay fever, hygiene, and household size. D P StrachanBMJ19892513902Yes
43324132413.00.00.0The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. J F WOESSNERArch. Biochem. Biophys.196113786180Yes
43448262413.0225.12112.6Management of hepatocellular carcinoma: an update. Jordi Bruix, Morris ShermanHepatology201121374666No
43548252412.5121.5560.8Angiogenesis in cancer and other diseases. P Carmeliet, R K JainNature200011001068No
43648092404.5235.3117.7The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. I F Benzie, J J StrainAnal. Biochem.19968660627Yes
43748062403.0168.5984.3"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. A P Feinberg, B VogelsteinAnal. Biochem.19846329026Yes
438144142402.31212.26202.0Global cancer statistics, 2012. Lindsey A Torre, Freddie Bray, Rebecca L Siegel, Jacques Ferlay, Joannie Lortet-Tieulent, Ahmedin JemalCA Cancer J Clin201525651787Yes
43924002400.0125.9125.9Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. O W GriffithAnal. Biochem.19807416462Yes
44095982399.5396.1999.0Cancer statistics, 2010. Ahmedin Jemal, Rebecca Siegel, Jiaquan Xu, Elizabeth WardCA Cancer J Clin201020610543Yes
44147972398.5122.9361.5MicroRNA signatures in human cancers. George A Calin, Carlo M CroceNat. Rev. Cancer200617060945No
44223942394.072.6272.6The pathobiology of diabetic complications: a unifying mechanism. Michael BrownleeDiabetes200515919781No
44347832391.50.00.0Human malaria parasites in continuous culture. W Trager, J B JensenScience1976781840Yes
44423892389.097.8797.9Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence. Ilan H MeyerPsychol Bull200312956539No
44523882388.095.3395.3No adjustments are needed for multiple comparisons. K J RothmanEpidemiology19902081237Yes
44623832383.063.4163.4Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. H F DvorakN. Engl. J. Med.19863537791No
44747662383.0131.1965.6The plant immune system. Jonathan D G Jones, Jeffery L DanglNature200617108957No
44823792379.00.00.0DISC ELECTROPHORESIS. I. BACKGROUND AND THEORY. L ORNSTEINAnn. N. Y. Acad. Sci.196414240533Yes
44923722372.00.00.0Spectroscopic determination of tryptophan and tyrosine in proteins. H EdelhochBiochemistry19676049437Yes
45023722372.061.761.7Tolerance, danger, and the extended family. P MatzingerAnnu. Rev. Immunol.19948011301No
45123692369.00.00.0Statistical estimations in enzyme kinetics. G N WILKINSONBiochem. J.196113785321Yes
45247222361.00.00.0A new method for sequencing DNA. A M Maxam, W GilbertProc. Natl. Acad. Sci. U.S.A.1977265521Yes
45347212360.591.4245.7The language of covalent histone modifications. B D Strahl, C D AllisNature200010638745Yes
45447212360.5143.1471.6Voxel-based morphometry--the methods. J Ashburner, K J FristonNeuroimage200010860804No
45523572357.059.4859.5Inflammatory bowel disease. Daniel K PodolskyN. Engl. J. Med.200212167685No
45623562356.089.9189.9Functions of DNA methylation: islands, start sites, gene bodies and beyond. Peter A JonesNat. Rev. Genet.201222641018No
45723542354.056.2756.3One-step gene disruption in yeast. R J RothsteinMeth. Enzymol.19836310324Yes
45847052352.50.00.0The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. R C Graham, M J KarnovskyJ. Histochem. Cytochem.19665962951Yes
45923512351.050.1550.1RNA interference. Gregory J HannonNature200212110901No
46023462346.058.7158.7Angiogenesis in health and disease. Peter CarmelietNat. Med.200312778163No
46123452345.061.0961.1CpG-rich islands and the function of DNA methylation. A P BirdNature19862423876No
46223442344.057.2257.2Protein folding and misfolding. Christopher M DobsonNature200314685248No
46323432343.067.1767.2Chemokines--chemotactic cytokines that mediate inflammation. A D LusterN. Engl. J. Med.19989459648No
46423412341.074.8574.8Mesenchymal stem cells. A I CaplanJ. Orthop. Res.19911870029Yes
46523372337.058.758.7Mechanisms of angiogenesis and arteriogenesis. P CarmelietNat. Med.200010742145No
46623352335.0104.04104.0Inositol trisphosphate and diacylglycerol as second messengers. M J BerridgeBiochem. J.19846146314No
46723332333.00.00.0Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. J D RowleyNature19734126434Yes
46823262326.077.5677.6Phase separation of integral membrane proteins in Triton X-114 solution. C BordierJ. Biol. Chem.19816257680Yes
46946502325.0107.7753.9Emergence of scaling in random networks Barabasi, AlbertScience199910521342Yes
47023232323.0125.51125.5Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. T E MoffittPsychol Rev19938255953No
47123142314.052.0152.0The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Isaiah J FidlerNat. Rev. Cancer200312778135No
47269252308.3201.7567.2Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Da Wei Huang, Brad T Sherman, Richard A LempickiNucleic Acids Res.200919033363Yes
47323072307.077.2977.3EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. W KlimeschBrain Res. Brain Res. Rev.199910209231No
47423052305.058.1358.1Cardiac excitation-contraction coupling. Donald M BersNature200211805843No
47546062303.0179.8289.9The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. J Vieira, J MessingGene19826295879Yes
47669072302.3191.4763.8TopHat: discovering splice junctions with RNA-Seq. Cole Trapnell, Lior Pachter, Steven L SalzbergBioinformatics200919289445Yes
47746042302.0117.8858.9Oncomirs - microRNAs with a role in cancer. Aurora Esquela-Kerscher, Frank J SlackNat. Rev. Cancer200616557279No
47891762294.0263.3365.8Improved methods for building protein models in electron density maps and the location of errors in these models. T A Jones, J Y Zou, S W Cowan, M KjeldgaardActa Crystallogr., A, Found. Crystallogr.19912025413Yes
47922942294.065.165.1Obesity as a medical problem. P G KopelmanNature200010766250No
48022922292.00.00.0The magical number seven plus or minus two: some limits on our capacity for processing information. G A MILLERPsychol Rev195613310704Yes
48122872287.054.0754.1Alzheimer's disease is a synaptic failure. Dennis J SelkoeScience200212399581No
48291302282.5218.1154.5Cluster analysis and display of genome-wide expression patterns. M B Eisen, P T Spellman, P O Brown, D BotsteinProc. Natl. Acad. Sci. U.S.A.19989843981Yes
48322812281.051.951.9Toll-like receptors and innate immunity. R MedzhitovNat. Rev. Immunol.200111905821No
48422792279.048.5948.6Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling. P SchuckBiophys. J.200010692345Yes
48522762276.063.9664.0Photoelectrochemical cells. M GrätzelNature200111713540Yes
48622712271.074.274.2Optimal two-stage designs for phase II clinical trials. R SimonControl Clin Trials19892702835Yes
48722712271.082.8582.8Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis. Thomas WeltonChem. Rev.199911849019Yes
48822702270.090.0290.0Health promotion by social cognitive means. Albert BanduraHealth Educ Behav200415090118Yes
48945352267.5146.973.5TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. T R Mosmann, R L CoffmanAnnu. Rev. Immunol.19892523712No
49045142257.0151.3675.7ESTIMATING F-STATISTICS FOR THE ANALYSIS OF POPULATION STRUCTURE. B S Weir, C Clark CockerhamEvolution198428563791Yes
49122522252.088.3188.3Hepatocellular carcinoma. Hashem B El-SeragN. Engl. J. Med.201121992124No
49222512251.087.5387.5Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Sarah E BarlowPediatrics200718055651Yes
49390012250.2444.35111.1Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanAnn. Intern. Med.200919622511No
49422492249.050.550.5Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Shimon SakaguchiAnnu. Rev. Immunol.200415032588No
49522482248.052.1752.2Interleukin-12 and the regulation of innate resistance and adaptive immunity. Giorgio TrinchieriNat. Rev. Immunol.200312563297No
49622462246.00.00.0Estimation of the molecular weights of proteins by Sephadex gel-filtration. P AndrewsBiochem. J.19644158310Yes
49744872243.50.00.0Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. H Aviv, P LederProc. Natl. Acad. Sci. U.S.A.19724504350Yes
49889722243.0459.77114.9APACHE II: a severity of disease classification system. W A Knaus, E A Draper, D P Wagner, J E ZimmermanCrit. Care Med.19853928249Yes
49922252225.061.5161.5Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. S A BustinJ. Mol. Endocrinol.200011013345No
50022232223.0105.37105.4Half a century of research on the Stroop effect: an integrative review. C M MacLeodPsychol Bull19912034749No
50122232223.046.6846.7Genome maintenance mechanisms for preventing cancer. J H HoeijmakersNature200111357144No
50244462223.0146.9573.5Projections of global mortality and burden of disease from 2002 to 2030. Colin D Mathers, Dejan LoncarPLoS Med.200617132052Yes
50322182218.084.184.1Estimation of metabolite concentrations from localized in vivo proton NMR spectra. S W ProvencherMagn Reson Med19938139448Yes
50444322216.00.00.0A simplified method of evaluating dose-effect experiments. J T LITCHFIELD, F WILCOXONJ. Pharmacol. Exp. Ther.194918152921Yes
50522152215.075.2775.3ABC transporters: from microorganisms to man. C F HigginsAnnu. Rev. Cell Biol.19921282354No
50644232211.5122.9861.5Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. C Tuerk, L GoldScience19902200121Yes
50744142207.0125.5962.8Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. D B Smith, K S JohnsonGene19883047011Yes
50822052205.040.7140.7Mechanisms underlying ubiquitination. C M PickartAnnu. Rev. Biochem.200111395416No
50943962198.0175.5987.8Tissue engineering. R Langer, J P VacantiScience19938493529No
51021952195.055.7155.7Nuclear factor-kappaB in cancer development and progression. Michael KarinNature200616724054No
51121932193.0126.68126.7The short-form McGill Pain Questionnaire. R MelzackPain19873670870Yes
51221912191.059.9760.0Molecular chaperones in cellular protein folding. F U HartlNature19968637592No
51343782189.0120.3660.2Caspases: enemies within. N A Thornberry, Y LazebnikScience19989721091No
51421872187.063.2663.3Cadherin cell adhesion receptors as a morphogenetic regulator. M TakeichiScience19912006419No
51521852185.00.00.0A gene complex controlling segmentation in Drosophila. E B LewisNature1978103000Yes
51621852185.00.00.0Gene action in the X-chromosome of the mouse (Mus musculus L.). M F LYONNature196113764598Yes
517152762182.3386.4455.2UCSF Chimera--a visualization system for exploratory research and analysis. Eric F Pettersen, Thomas D Goddard, Conrad C Huang, Gregory S Couch, Daniel M Greenblatt, Elaine C Meng, Thomas E FerrinJ Comput Chem200415264254Yes
51821822182.051.5351.5Papillomaviruses and cancer: from basic studies to clinical application. Harald zur HausenNat. Rev. Cancer200212044010No
51987172179.20.00.0Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. P W Rigby, M Dieckmann, C Rhodes, P BergJ. Mol. Biol.1977881736Yes
52021712171.00.00.0Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A. S W KesslerJ. Immunol.19751102604Yes
52121712171.00.00.0Perceived exertion as an indicator of somatic stress. G BorgScand J Rehabil Med19705523831Yes
52265002166.7234.4278.1Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Y Gavrieli, Y Sherman, S A Ben-SassonJ. Cell Biol.19921400587Yes
52321652165.058.7558.8Mitochondrial formation of reactive oxygen species. Julio F TurrensJ. Physiol. (Lond.)200314561818No
52443202160.0198.5299.3Longitudinal data analysis for discrete and continuous outcomes. S L Zeger, K Y LiangBiometrics19863719049Yes
52521602160.065.8165.8Predictive reward signal of dopamine neurons. W SchultzJ. Neurophysiol.19989658025No
52621592159.059.1959.2Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Ting-Chao ChouPharmacol. Rev.200616968952No
52721552155.00.00.0On the number of segregating sites in genetical models without recombination. G A WattersonTheor Popul Biol19751145509Yes
52843072153.50.00.0PERIODONTAL DISEASE IN PREGNANCY. II. CORRELATION BETWEEN ORAL HYGIENE AND PERIODONTAL CONDTION. J SILNESS, H LOEActa Odontol. Scand.196414158464Yes
52921532153.00.00.0Pharmacological implications of microsomal enzyme induction. A H ConneyPharmacol. Rev.19674383307Yes
53021532153.056.456.4Cell adhesion: the molecular basis of tissue architecture and morphogenesis. B M GumbinerCell19968608588No
53121472147.048.7648.8The danger model: a renewed sense of self. Polly MatzingerScience200211951032Yes
53242912145.5105.1752.6Establishment in culture of pluripotential cells from mouse embryos. M J Evans, M H KaufmanNature19817242681Yes
53321452145.092.6692.7The processing-speed theory of adult age differences in cognition. T A SalthousePsychol Rev19968759042No
53421452145.063.1563.1The genetic legacy of the Quaternary ice ages. G HewittNature200010879524No
53521442144.076.1976.2Gene regulation by steroid hormones. M BeatoCell19892644044No
53621412141.043.843.8Wnt signaling and cancer. P PolakisGenes Dev.200010921899No
53721372137.00.00.0Analysis of gene diversity in subdivided populations. M NeiProc. Natl. Acad. Sci. U.S.A.19734519626Yes
53842722136.0111.8355.9Oxidants, oxidative stress and the biology of ageing. T Finkel, N J HolbrookNature200011089981No
53942652132.50.00.0Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. C Beauchamp, I FridovichAnal. Biochem.19714943714Yes
54063912130.3261.9987.3Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. R A Deyo, D C Cherkin, M A CiolJ Clin Epidemiol19921607900Yes
54121302130.064.1664.2Cell death during development of the nervous system. R W OppenheimAnnu. Rev. Neurosci.19912031577No
54221232123.065.5965.6Recent advances with liposomes as pharmaceutical carriers. Vladimir P TorchilinNat Rev Drug Discov200515688077No
54342342117.0173.3286.7Computed tomography--an increasing source of radiation exposure. David J Brenner, Eric J HallN. Engl. J. Med.200718046031No
54463442114.7290.8196.9Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. R M Palmer, A G Ferrige, S MoncadaNature19873495737Yes
54542252112.5114.5857.3High-efficiency transformation of mammalian cells by plasmid DNA. C Chen, H OkayamaMol. Cell. Biol.19873670292Yes
54642242112.0124.4562.2Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. T C Chou, P TalalayAdv. Enzyme Regul.19846382953Yes
54721122112.054.6554.6TGFbeta in Cancer. Joan MassaguéCell200818662538No
54821112111.00.00.0A relation between non-esterified fatty acids in plasma and the metabolism of glucose. V P DOLEJ. Clin. Invest.195613286333Yes
54942182109.0134.467.2Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. F W Studier, B A MoffattJ. Mol. Biol.19863537305Yes
55063202106.7210.4670.2Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. G Evanno, S Regnaut, J GoudetMol. Ecol.200515969739Yes
55121062106.071.8871.9Non-coding RNAs in human disease. Manel EstellerNat. Rev. Genet.201122094949No
55221052105.00.00.0The glomerular permeability determined by dextran clearance using Sephadex gel filtration. C E MogensenScand. J. Clin. Lab. Invest.19685637478Yes
55321052105.085.9786.0Psychometric properties of the strengths and difficulties questionnaire. R GoodmanJ Am Acad Child Adolesc Psychiatry200111699809Yes
55463022100.7155.3851.8The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. R C Lee, R L Feinbaum, V AmbrosCell19938252621Yes
55541972098.596.4748.2Innate immune recognition. Charles A Janeway, Ruslan MedzhitovAnnu. Rev. Immunol.200211861602No
55662902096.71406.94469.0Cancer statistics, 2018. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201829313949Yes
55720932093.00.00.0EQUILIBRIUM ULTRACENTRIFUGATION OF DILUTE SOLUTIONS. D A YPHANTISBiochemistry196414155091Yes
55862452081.7197.2165.7Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. C M Gorman, L F Moffat, B H HowardMol. Cell. Biol.19826960240Yes
55941632081.5180.8290.4Measuring agreement in method comparison studies. J M Bland, D G AltmanStat Methods Med Res199910501650No
56041592079.5190.1495.1A method of comparing the areas under receiver operating characteristic curves derived from the same cases. J A Hanley, B J McNeilRadiology19836878708Yes
56183122078.0556.87139.2Cancer statistics, 2014. Rebecca Siegel, Jiemin Ma, Zhaohui Zou, Ahmedin JemalCA Cancer J Clin201424399786Yes
56220742074.081.3781.4Delayed neuronal death in the gerbil hippocampus following ischemia. T KirinoBrain Res.19827093691Yes
56341472073.50.00.0Assessment of outcome after severe brain damage. B Jennett, M BondLancet197546957Yes
56420732073.00.00.0A protein binding assay for adenosine 3':5'-cyclic monophosphate. A G GilmanProc. Natl. Acad. Sci. U.S.A.19704318781Yes
56541442072.0125.8562.9Fast and accurate long-read alignment with Burrows-Wheeler transform. Heng Li, Richard DurbinBioinformatics201020080505Yes
56641352067.5163.8681.9mTOR signaling in growth control and disease. Mathieu Laplante, David M SabatiniCell201222500797No
56741322066.0117.5258.8In vitro selection of RNA molecules that bind specific ligands. A D Ellington, J W SzostakNature19901697402Yes
56820652065.049.4749.5Principles of CDK regulation. D O MorganNature19957877684No
56920612061.056.3456.3Memory--a century of consolidation. J L McGaughScience200010634773No
57041132056.50.00.0Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Glowinski, L L IversenJ. Neurochem.19665950056Yes
57181942048.5312.4778.1Establishing a standard definition for child overweight and obesity worldwide: international survey. T J Cole, M C Bellizzi, K M Flegal, W H DietzBMJ200010797032Yes
57220482048.00.00.0Models for the specific adhesion of cells to cells. G I BellScience1978347575No
57361322044.0186.7562.2Understanding the Warburg effect: the metabolic requirements of cell proliferation. Matthew G Vander Heiden, Lewis C Cantley, Craig B ThompsonScience200919460998No
57420392039.076.0576.0Primate models of movement disorders of basal ganglia origin. M R DeLongTrends Neurosci.19901695404No
57520372037.047.4247.4Getting started with yeast. F ShermanMeth. Enzymol.19912005794Yes
57620312031.00.00.0Measurement of pain. E C HuskissonLancet19744139420Yes
57740572028.5116.2658.1Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. D Hanahan, J FolkmanCell19968756718No
57820242024.086.3186.3Essential oils: their antibacterial properties and potential applications in foods--a review. Sara BurtInt. J. Food Microbiol.200415246235No
57940442022.0138.0869.0Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. S Duval, R TweedieBiometrics200010877304Yes
58020212021.074.3474.3Implications of normal brain development for the pathogenesis of schizophrenia. D R WeinbergerArch. Gen. Psychiatry19873606332Yes
58120182018.057.7957.8Structure and function of telomeres. E H BlackburnNature19911708110No
58240332016.50.00.0PERIODONTAL DISEASE IN PREGNANCY. I. PREVALENCE AND SEVERITY. H LOE, J SILNESSActa Odontol. Scand.196314121956Yes
58340332016.5135.8167.9The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Taro Kawai, Shizuo AkiraNat. Immunol.201020404851No
58420142014.050.3450.3Salt and drought stress signal transduction in plants. Jian-Kang ZhuAnnu Rev Plant Biol200212221975No
58540242012.0262.58131.3Revised methods for the Salmonella mutagenicity test. D M Maron, B N AmesMutat. Res.19836341825Yes
58640222011.0144.8272.4Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. K Tamura, M NeiMol. Biol. Evol.19938336541Yes
58720092009.054.3254.3Prostaglandins and leukotrienes: advances in eicosanoid biology. C D FunkScience200111729303No
58820052005.058.0658.1Origin and physiological roles of inflammation. Ruslan MedzhitovNature200818650913No
58940072003.50.00.0Pain mechanisms: a new theory. R Melzack, P D WallScience19655320816No
59040072003.5139.6269.8Adherence to medication. Lars Osterberg, Terrence BlaschkeN. Engl. J. Med.200516079372No
59140022001.0127.4563.7Unified segmentation. John Ashburner, Karl J FristonNeuroimage200515955494Yes
59240002000.0106.0553.0WGCNA: an R package for weighted correlation network analysis. Peter Langfelder, Steve HorvathBMC Bioinformatics200819114008Yes
59339831991.5117.5258.8Exploring the full spectrum of macrophage activation. David M Mosser, Justin P EdwardsNat. Rev. Immunol.200819029990No
59439741987.0144.0372.0Complex brain networks: graph theoretical analysis of structural and functional systems. Ed Bullmore, Olaf SpornsNat. Rev. Neurosci.200919190637No
59519831983.053.2353.2Epigenetics in cancer. Manel EstellerN. Engl. J. Med.200818337604No
59659451981.70.00.0Immunochemical quantitation of antigens by single radial immunodiffusion. G Mancini, A O Carbonara, J F HeremansImmunochemistry19654956917Yes
59719801980.084.2584.2Matrix metalloproteinases and their inhibitors in connective tissue remodeling. J F WoessnerFASEB J.19911850705No
59859391979.7160.2453.4Pathogen recognition and innate immunity. Shizuo Akira, Satoshi Uematsu, Osamu TakeuchiCell200616497588No
59919761976.080.3180.3Inositol trisphosphate and diacylglycerol: two interacting second messengers. M J BerridgeAnnu. Rev. Biochem.19873304132No
60019741974.00.00.0Transduction of linked genetic characters of the host by bacteriophage P1. E S LENNOXVirology195513267987Yes
60159161972.00.00.0Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. G Fairbanks, T L Steck, D F WallachBiochemistry19714326772Yes
60219721972.00.00.0Some factors in the interpretation of protein denaturation. W KAUZMANNAdv. Protein Chem.195914404936Yes
60319691969.00.00.0The genetical structure of populations. S WRIGHTAnn Eugen195124540312Yes
60439341967.085.6942.8CDK inhibitors: positive and negative regulators of G1-phase progression. C J Sherr, J M RobertsGenes Dev.199910385618No
60519671967.00.00.0A study of fixation for electron microscopy. G E PALADEJ. Exp. Med.195214927794Yes
60639331966.50.00.0Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. S Marklund, G MarklundEur. J. Biochem.19744215654Yes
60719641964.00.00.0Intracellular aspects of the process of protein synthesis. G PaladeScience19751096303No
60819601960.065.5665.6Drug combination studies and their synergy quantification using the Chou-Talalay method. Ting-Chao ChouCancer Res.201020068163Yes
60919571957.049.6549.6Bone resorption by osteoclasts. S L TeitelbaumScience200010968780No
61019571957.054.6354.6Vascular endothelial growth factor: basic science and clinical progress. Napoleone FerraraEndocr. Rev.200415294883No
61119511951.057.5157.5The resurgence of platinum-based cancer chemotherapy. Lloyd KellandNat. Rev. Cancer200717625587No
61219511951.082.2982.3Ethical authorship and publishing. Andrew J S CoatsInt. J. Cardiol.200919046787No
61339021951.0236.2118.1GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research--an update. Rod Peakall, Peter E SmouseBioinformatics201222820204Yes
61439011950.588.1544.1MicroRNAs: small RNAs with a big role in gene regulation. Lin He, Gregory J HannonNat. Rev. Genet.200415211354No
61538971948.5159.4879.7The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Stephen B Edge, Carolyn C ComptonAnn. Surg. Oncol.201020180029No
61619461946.063.4163.4The transforming growth factor-beta family. J MassaguéAnnu. Rev. Cell Biol.19902177343No
617175021944.7531.4759.1The Sequence Alignment/Map format and SAMtools. Heng Li, Bob Handsaker, Alec Wysoker, Tim Fennell, Jue Ruan, Nils Homer, Gabor Marth, Goncalo Abecasis, Richard DurbinBioinformatics200919505943Yes
61838841942.00.00.0The fluid mosaic model of the structure of cell membranes. S J Singer, G L NicolsonScience19724333397Yes
61919391939.00.00.0Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. P MITCHELLNature196113771349Yes
62058131937.7359.22119.7HTSeq--a Python framework to work with high-throughput sequencing data. Simon Anders, Paul Theodor Pyl, Wolfgang HuberBioinformatics201525260700Yes
62119371937.063.2563.2The nerve growth factor 35 years later. R Levi-MontalciniScience19873306916No
622154931936.6390.9748.9The Protein Data Bank. H M Berman, J Westbrook, Z Feng, G Gilliland, T N Bhat, H Weissig, I N Shindyalov, P E BourneNucleic Acids Res.200010592235Yes
62319261926.00.00.0A rapid radiochemical method for the determination of choline acetyltransferase. F FonnumJ. Neurochem.19751113118Yes
62419251925.048.3848.4Molecular physiology of P2X receptors. R Alan NorthPhysiol. Rev.200212270951No
62519201920.083.7783.8A computational approach to edge detection. J CannyIEEE Trans Pattern Anal Mach Intell198621869365Yes
62695821916.4462.2692.5The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. D J Buysse, C F Reynolds, T H Monk, S R Berman, D J KupferPsychiatry Res19892748771Yes
62757471915.7119.9740.0Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Ron Edgar, Michael Domrachev, Alex E LashNucleic Acids Res.200211752295Yes
62838271913.593.446.7Inflammation and cancer: back to Virchow? F Balkwill, A MantovaniLancet200111229684No
62919131913.056.3356.3Cancer nanotechnology: opportunities and challenges. Mauro FerrariNat. Rev. Cancer200515738981No
63019121912.065.8965.9Two-sided confidence intervals for the single proportion: comparison of seven methods. R G NewcombeStat Med19989595616Yes
63138231911.5157.6578.8Glutathione. A Meister, M E AndersonAnnu. Rev. Biochem.19836137189No
63219081908.049.1449.1Angiogenesis in life, disease and medicine. Peter CarmelietNature200516355210No
63319071907.060.060.0Cellular and molecular mechanisms of fibrosis. T A WynnJ. Pathol.200818161745No
63438091904.587.6143.8Lipid rafts and signal transduction. K Simons, D ToomreNat. Rev. Mol. Cell Biol.200011413487No
63519041904.038.4738.5Java Treeview--extensible visualization of microarray data. Alok J SaldanhaBioinformatics200415180930Yes
63657111903.70.00.0THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY. F C GREENWOOD, W M HUNTER, J S GLOVERBiochem. J.196314097352Yes
63719021902.051.7551.8MapChart: software for the graphical presentation of linkage maps and QTLs. R E VoorripsJ. Hered.200212011185Yes
63838031901.5147.1373.6Inositol trisphosphate, a novel second messenger in cellular signal transduction. M J Berridge, R F IrvineNature19846095092No
63918981898.00.00.0The gel-filtration behaviour of proteins related to their molecular weights over a wide range. P AndrewsBiochem. J.19655862401Yes
64018921892.0104.33104.3Qualitative research. Introducing focus groups. J KitzingerBMJ19957633241Yes
64137831891.582.9341.5Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. D Bonnet, J E DickNat. Med.19979212098Yes
64256731891.00.00.0The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. R J HAVEL, H A EDER, J H BRAGDONJ. Clin. Invest.195513252080Yes
64318901890.070.2570.2What are the functional consequences of neurocognitive deficits in schizophrenia? M F GreenAm J Psychiatry19968610818No
64437771888.5153.9577.0The neural basis of drug craving: an incentive-sensitization theory of addiction. T E Robinson, K C BerridgeBrain Res. Brain Res. Rev.19938401595No
64537751887.5120.4660.2Management of hepatocellular carcinoma. Jordi Bruix, Morris ShermanHepatology200516250051No
64618871887.00.00.0Satellite cell of skeletal muscle fibers. A MAUROJ Biophys Biochem Cytol196113768451Yes
64737701885.0104.3352.2Autophagy in the pathogenesis of disease. Beth Levine, Guido KroemerCell200818191218No
64837491874.5140.2270.1Rapid isolation of high molecular weight plant DNA. M G Murray, W F ThompsonNucleic Acids Res.19807433111Yes
64918741874.092.1392.1Measures of reliability in sports medicine and science. W G HopkinsSports Med200010907753Yes
65037441872.0158.7179.4The L-arginine-nitric oxide pathway. S Moncada, A HiggsN. Engl. J. Med.19937504210No
65118711871.053.8253.8Causes and consequences of microRNA dysregulation in cancer. Carlo M CroceNat. Rev. Genet.200919763153No
65218681868.044.8144.8Evolving concepts of rheumatoid arthritis. Gary S FiresteinNature200312748655No
65337301865.083.7141.9Untangling the ErbB signalling network. Y Yarden, M X SliwkowskiNat. Rev. Mol. Cell Biol.200111252954No
65418651865.0133.64133.6Executive functions. Adele DiamondAnnu Rev Psychol201323020641No
65518611861.047.5847.6A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Douglas C WallaceAnnu. Rev. Genet.200516285865No
65618581858.063.7763.8The anatomy and taxonomy of protein structure. J S RichardsonAdv. Protein Chem.19817020376No
65718561856.048.1648.2Autophagy: process and function. Noboru MizushimaGenes Dev.200718006683No
65837081854.00.00.0Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. J Sedlak, R H LindsayAnal. Biochem.19684973948Yes
65937061853.00.00.0The serial cultivation of human diploid cell strains. L HAYFLICK, P S MOORHEADExp. Cell Res.196113905658Yes
66018521852.041.9341.9Tumour-educated macrophages promote tumour progression and metastasis. Jeffrey W PollardNat. Rev. Cancer200414708027No
66137021851.081.6540.8The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Igor Vivanco, Charles L SawyersNat. Rev. Cancer200212094235No
66237001850.0114.8757.4Calculation of protein extinction coefficients from amino acid sequence data. S C Gill, P H von HippelAnal. Biochem.19892610349Yes
66336951847.50.00.0Electrochemical photolysis of water at a semiconductor electrode. A Fujishima, K HondaNature197212635268Yes
66436911845.50.00.0Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. L A Greene, A S TischlerProc. Natl. Acad. Sci. U.S.A.19761065897Yes
66518451845.058.4358.4The magical number 4 in short-term memory: a reconsideration of mental storage capacity. N CowanBehav Brain Sci200111515286Yes
66618401840.058.458.4Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. E C ButcherCell19911760836No
66718371837.00.00.0Colorimetric assay of catalase. A K SinhaAnal. Biochem.19724556490Yes
66873451836.2353.7788.4Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanBMJ200919622551No
66936721836.00.00.0A general method applicable to the search for similarities in the amino acid sequence of two proteins. S B Needleman, C D WunschJ. Mol. Biol.19705420325Yes
67018341834.00.00.0On estimating the relation between blood group and disease. B WOOLFAnn. Hum. Genet.195514388528Yes
67118331833.00.00.0[Rapid physiological coagulation method in determination of fibrinogen]. A CLAUSSActa Haematol.195713434757Yes
67218301830.047.6147.6G1 phase progression: cycling on cue. C J SherrCell19947954821No
67318301830.052.4452.4Ischemic cell death in brain neurons. P LiptonPhysiol. Rev.199910508238No
67418271827.00.00.0Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method. L SVENNERHOLMBiochim. Biophys. Acta195713436486Yes
67536531826.594.7747.4Death receptors: signaling and modulation. A Ashkenazi, V M DixitScience19989721089No
67618261826.054.4154.4Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. G P SmithScience19854001944Yes
67718251825.044.3944.4Universal control mechanism regulating onset of M-phase. P NurseNature19902138713No
67818241824.065.2165.2Japanese Classification of Gastric Carcinoma - 2nd English Edition - Japanese Gastric Cancer AssociationGastric Cancer199811957040Yes
67936461823.085.1642.6A novel genetic system to detect protein-protein interactions. S Fields, O SongNature19892547163Yes
68018211821.072.7272.7SF-36 health survey update. J E WareSpine200011124729No
68118151815.088.9288.9You want to measure coping but your protocol's too long: consider the brief COPE. C S CarverInt J Behav Med199716250744Yes
68236301815.095.3147.7Signal integration in the endoplasmic reticulum unfolded protein response. David Ron, Peter WalterNat. Rev. Mol. Cell Biol.200717565364No
68318141814.046.3646.4Mitochondrial diseases in man and mouse. D C WallaceScience199910066162No
684108711811.8292.7548.8Phaser crystallographic software. Airlie J McCoy, Ralf W Grosse-Kunstleve, Paul D Adams, Martyn D Winn, Laurent C Storoni, Randy J ReadJ Appl Crystallogr200719461840Yes
68518111811.085.985.9Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. Joseph P WeirJ Strength Cond Res200515705040No
68618091809.040.4440.4The molecular biology of memory storage: a dialogue between genes and synapses. E R KandelScience200111691980No
68718091809.00.00.0A RAPID PERMETHYLATION OF GLYCOLIPID, AND POLYSACCHARIDE CATALYZED BY METHYLSULFINYL CARBANION IN DIMETHYL SULFOXIDE. S HAKOMORIJ. Biochem.196414135466Yes
68836121806.080.0740.0Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Yigong Shi, Joan MassaguéCell200312809600No
68918041804.00.00.0The information capacity of the human motor system in controlling the amplitude of movement. P M FITTSJ Exp Psychol195413174710Yes
69036071803.5174.5587.3Self-rated health and mortality: a review of twenty-seven community studies. E L Idler, Y BenyaminiJ Health Soc Behav19979097506No
69136071803.588.2344.1New functions for the matrix metalloproteinases in cancer progression. Mikala Egeblad, Zena WerbNat. Rev. Cancer200211990853No
69218031803.044.6844.7NOX enzymes and the biology of reactive oxygen. J David LambethNat. Rev. Immunol.200415039755No
69335971798.50.00.0Screening lambdagt recombinant clones by hybridization to single plaques in situ. W D Benton, R W DavisScience1977322279Yes
69435931796.5126.0663.0Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. C J Murray, A D LopezLancet19979167458Yes
69517961796.061.7661.8Dominant forces in protein folding. K A DillBiochemistry19902207096No
69617941794.00.00.0A simple technique for demonstrating centromeric heterochromatin. A T SumnerExp. Cell Res.19724117921Yes
69735831791.50.00.0A modified uronic acid carbazole reaction. T BITTER, H M MUIRAnal. Biochem.196213971270Yes
69853731791.0140.947.0The biology of VEGF and its receptors. Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouterNat. Med.200312778165No
69953691789.7404.3134.8Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. P J Van Soest, J B Robertson, B A LewisJ. Dairy Sci.19911660498No
70035791789.5174.9687.5A feature-integration theory of attention. A M Treisman, G GeladeCogn Psychol19807351125Yes
70117861786.095.395.3Effective physician-patient communication and health outcomes: a review. M A StewartCMAJ19957728691Yes
70235651782.599.7549.9Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Weizhong Li, Adam GodzikBioinformatics200616731699Yes
70317771777.074.2874.3Working memory. A BaddeleyScience19921736359No
70417731773.064.2364.2Scaffolds in tissue engineering bone and cartilage. D W HutmacherBiomaterials200011071603Yes
70535451772.5154.5677.3Random-effects models for longitudinal data. N M Laird, J H WareBiometrics19827168798Yes
70617701770.046.646.6Chemokines and leukocyte traffic. M BaggioliniNature19989560152No
70717701770.062.7262.7RELION: implementation of a Bayesian approach to cryo-EM structure determination. Sjors H W ScheresJ. Struct. Biol.201223000701Yes
70817621762.047.547.5Calcium signaling. David E ClaphamCell200718083096No
70917611761.049.3749.4SV40-transformed simian cells support the replication of early SV40 mutants. Y GluzmanCell19816260373Yes
71017591759.045.6445.6Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. T HunterCell19957834742No
71117541754.038.1938.2NK cell recognition. Lewis L LanierAnnu. Rev. Immunol.200515771571No
71217511751.054.2554.2Immunological and inflammatory functions of the interleukin-1 family. Charles A DinarelloAnnu. Rev. Immunol.200919302047No
71335001750.0181.1990.6A simple, rapid, and sensitive DNA assay procedure. C Labarca, K PaigenAnal. Biochem.19806158890Yes
71434981749.00.00.0A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. S REITMAN, S FRANKELAm. J. Clin. Pathol.195713458125Yes
71517481748.087.8187.8Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. H W SteinbuschNeuroscience19817017455Yes
71617471747.040.6140.6Telomere measurement by quantitative PCR. Richard M CawthonNucleic Acids Res.200212000852Yes
71717471747.050.5650.6Molecular basis of bacterial outer membrane permeability revisited. Hiroshi NikaidoMicrobiol. Mol. Biol. Rev.200314665678No
71817471747.041.1441.1Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Shimon SakaguchiNat. Immunol.200515785760No
71917451745.00.00.0The biology of oxygen radicals. I FridovichScience1978210504Yes
72017451745.077.4877.5Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. B SamuelssonScience19836301011Yes
72134861743.00.00.0A method for determining the sedimentation behavior of enzymes: application to protein mixtures. R G MARTIN, B N AMESJ. Biol. Chem.196113767412Yes
72234851742.5120.1860.1Neural mechanisms of selective visual attention. R Desimone, J DuncanAnnu. Rev. Neurosci.19957605061No
72334851742.5109.5554.8Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Marie-Christine Daniel, Didier AstrucChem. Rev.200414719978No
72469661741.5232.4558.1GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. Berk Hess, Carsten Kutzner, David van der Spoel, Erik LindahlJ Chem Theory Comput200826620784Yes
72552231741.0181.7160.6Bacterial biofilms: a common cause of persistent infections. J W Costerton, P S Stewart, E P GreenbergScience199910334980No
72617401740.00.00.0Elastic properties of lipid bilayers: theory and possible experiments. W HelfrichZ Naturforsch C19734273690Yes
72717401740.064.3764.4Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. H G GratznerScience19827123245Yes
72817381738.035.7535.8Targeting RAS signalling pathways in cancer therapy. Julian DownwardNat. Rev. Cancer200312509763No
72934751737.5139.6369.8Complex network measures of brain connectivity: uses and interpretations. Mikail Rubinov, Olaf SpornsNeuroimage201019819337Yes
73017371737.035.8635.9Histone acetylation in chromatin structure and transcription. M GrunsteinNature19979311776No
73117371737.066.1266.1Accelerated Profile HMM Searches. Sean R EddyPLoS Comput. Biol.201122039361Yes
73217361736.061.5761.6Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose. J Kyhse-AndersenJ. Biochem. Biophys. Methods19846530509Yes
73334721736.0105.5552.8Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. E Lander, L KruglyakNat. Genet.19957581446Yes
73452061735.3158.1252.7RNA-Seq: a revolutionary tool for transcriptomics. Zhong Wang, Mark Gerstein, Michael SnyderNat. Rev. Genet.200919015660No
73517321732.072.2472.2Reactive oxygen species and the central nervous system. B HalliwellJ. Neurochem.19921402908No
73634641732.089.5844.8Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. F Sallusto, A LanzavecchiaJ. Exp. Med.19948145033Yes
73717311731.00.00.0Protein purification by affinity chromatography. Derivatizations of agarose and polyacrylamide beads. P CuatrecasasJ. Biol. Chem.19705432796Yes
73817301730.00.00.0Isolation by Distance. S WrightGenetics194317247074Yes
73917251725.054.1554.1Dietary pattern analysis: a new direction in nutritional epidemiology. Frank B HuCurr. Opin. Lipidol.200211790957No
74017241724.081.4981.5Glutamate, nitric oxide and cell-cell signalling in the nervous system. J GarthwaiteTrends Neurosci.19911708538No
74117241724.059.9159.9Physiology and neurobiology of stress and adaptation: central role of the brain. Bruce S McEwenPhysiol. Rev.200717615391No
74234421721.0100.450.2A global optimisation method for robust affine registration of brain images. M Jenkinson, S SmithMed Image Anal200111516708Yes
74317191719.045.5345.5The regulation of AP-1 activity by mitogen-activated protein kinases. M KarinJ. Biol. Chem.19957622446No
74417191719.048.6648.7A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Pascal FriesTrends Cogn. Sci. (Regul. Ed.)200516150631No
74517181718.062.5962.6Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. P CorreaCancer Res.19921458460No
74617181718.073.3573.3Role of oxidative stress in development of complications in diabetes. J W BaynesDiabetes19912010041No
74717181718.050.550.5Biology of natural killer cells. G TrinchieriAdv. Immunol.19892683611No
74817171717.00.00.0Muscle structure and theories of contraction. A F HUXLEYProg Biophys Biophys Chem195713485191Yes
74934331716.5100.1950.1Signal transduction by receptors with tyrosine kinase activity. A Ullrich, J SchlessingerCell19902158859No
75034301715.089.0644.5AKT/PKB signaling: navigating downstream. Brendan D Manning, Lewis C CantleyCell200717604717No
75117121712.053.353.3A model for receptor-regulated calcium entry. J W PutneyCell Calcium19862420465No
75234241712.0132.7966.4Missing data: our view of the state of the art. Joseph L Schafer, John W GrahamPsychol Methods200212090408Yes
75334241712.085.1742.6Mass spectrometry-based proteomics. Ruedi Aebersold, Matthias MannNature200312634793No
75434231711.50.00.0Quantitative film detection of 3H and 14C in polyacrylamide gels by fluorography. R A Laskey, A D MillsEur. J. Biochem.19751175627Yes
75517111711.00.00.0SEDIMENTATION STUDIES OF THE SIZE AND SHAPE OF DNA. F W STUDIERJ. Mol. Biol.196514290352Yes
75634211710.5197.7598.9Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. N S Jacobson, P TruaxJ Consult Clin Psychol19912002127Yes
75734211710.593.1446.6The Bcl-2 protein family: arbiters of cell survival. J M Adams, S CoryScience19989735050No
75834191709.599.7249.9Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Klaus Apel, Heribert HirtAnnu Rev Plant Biol200415377225No
75934131706.5138.8369.4Accurate and simple analytic representation of the electron-gas correlation energy. Perdew, WangPhys. Rev., B Condens. Matter199210001404Yes
76034081704.0185.5692.8The qualitative content analysis process. Satu Elo, Helvi KyngäsJ Adv Nurs200818352969Yes
76117031703.043.8443.8Complement. First of two parts. M J WalportN. Engl. J. Med.200111287977No
76216991699.065.0865.1Biodiesel from microalgae. Yusuf ChistiBiotechnol. Adv.200717350212No
76333901695.00.00.0The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. H P Misra, I FridovichJ. Biol. Chem.19724623845Yes
76433901695.00.00.0The interpretation of protein structures: estimation of static accessibility. B Lee, F M RichardsJ. Mol. Biol.19715551392Yes
76533891694.595.3947.7Protein misfolding, functional amyloid, and human disease. Fabrizio Chiti, Christopher M DobsonAnnu. Rev. Biochem.200616756495No
76616931693.068.1768.2The unbiased estimation of number and sizes of arbitrary particles using the disector. D C SterioJ Microsc19846737468Yes
76716931693.045.1945.2A decade of molecular biology of retinoic acid receptors. P ChambonFASEB J.19968801176No
76816921692.00.00.0Catheter replacement of the needle in percutaneous arteriography; a new technique. S I SELDINGERActa radiol195313057644Yes
76916921692.048.748.7Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Edward V LoftusGastroenterology200415168363Yes
77033791689.5109.6454.8Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. C W Elston, I O EllisHistopathology19911757079Yes
77116891689.036.1136.1Shelterin: the protein complex that shapes and safeguards human telomeres. Titia de LangeGenes Dev.200516166375No
77216891689.083.6783.7The Danish Civil Registration System. Carsten Bøcker PedersenScand J Public Health201121775345Yes
773101291688.2467.1877.9Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. Paul A Harris, Robert Taylor, Robert Thielke, Jonathon Payne, Nathaniel Gonzalez, Jose G CondeJ Biomed Inform200918929686Yes
77416871687.065.965.9A two process model of sleep regulation. A A BorbélyHum Neurobiol19827185792Yes
77550491683.0108.6836.2Control of regulatory T cell development by the transcription factor Foxp3. Shohei Hori, Takashi Nomura, Shimon SakaguchiScience200312522256Yes
77616801680.00.00.0The membrane actions of anesthetics and tranquilizers. P SeemanPharmacol. Rev.19724565956No
77716791679.047.8847.9Social controls on cell survival and cell death. M C RaffNature19921557121No
77816791679.053.9954.0The heme oxygenase system: a regulator of second messenger gases. M D MainesAnnu. Rev. Pharmacol. Toxicol.19979131263No
779100711678.5418.3769.7Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Jacques Ferlay, Hai-Rim Shin, Freddie Bray, David Forman, Colin Mathers, Donald Maxwell ParkinInt. J. Cancer201021351269Yes
78033531676.5110.5655.3Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Michael D Fox, Marcus E RaichleNat. Rev. Neurosci.200717704812No
78116761676.044.5644.6Modularity and community structure in networks. M E J NewmanProc. Natl. Acad. Sci. U.S.A.200616723398Yes
78216741674.057.0257.0Estimating causal effects from large data sets using propensity scores. D B RubinAnn. Intern. Med.19979382394No
78316701670.059.7959.8Molecular diversity of glutamate receptors and implications for brain function. S NakanishiScience19921329206No
78433401670.00.00.0Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. J D WATSON, F H CRICKNature195313054692Yes
78533371668.50.00.0The Social Readjustment Rating Scale. T H Holmes, R H RaheJ Psychosom Res19676059863Yes
78616681668.069.1969.2Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. W A CraigClin. Infect. Dis.19989455502No
78733351667.5109.2354.6Pattern recognition receptors and inflammation. Osamu Takeuchi, Shizuo AkiraCell201020303872No
78833331666.50.00.0Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. T V Bliss, T LomoJ. Physiol. (Lond.)19734727084Yes
78966651666.2241.9560.5Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Qiong Wang, George M Garrity, James M Tiedje, James R ColeAppl. Environ. Microbiol.200717586664Yes
79016661666.085.7685.8FreeSurfer. Bruce FischlNeuroimage201222248573No
79116651665.074.4974.5What is value in health care? Michael E PorterN. Engl. J. Med.201021142528Yes
79233261663.0106.1853.1Organization and expression of eucaryotic split genes coding for proteins. R Breathnach, P ChambonAnnu. Rev. Biochem.19816791577No
79333181659.095.4847.7Nonparametric permutation tests for functional neuroimaging: a primer with examples. Thomas E Nichols, Andrew P HolmesHum Brain Mapp200211747097Yes
79416571657.053.4953.5Descending control of pain. Mark J MillanProg. Neurobiol.200212034378No
79533131656.5101.5550.8Acute-phase proteins and other systemic responses to inflammation. C Gabay, I KushnerN. Engl. J. Med.19999971870No
79616561656.046.3346.3Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens. Jane GlazebrookAnnu Rev Phytopathol200516078883No
79716551655.040.5440.5Cisplatin: mode of cytotoxic action and molecular basis of resistance. Zahid H SiddikOncogene200314576837No
79816551655.058.6858.7adegenet: a R package for the multivariate analysis of genetic markers. Thibaut JombartBioinformatics200818397895Yes
79916531653.072.1872.2Secretory products of macrophages. C F NathanJ. Clin. Invest.19873543052No
80016531653.00.00.0The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. S BOYDENJ. Exp. Med.196213872176Yes
80133051652.5101.0950.5The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Karen Bedard, Karl-Heinz KrausePhysiol. Rev.200717237347No
80233031651.572.3736.2Network biology: understanding the cell's functional organization. Albert-László Barabási, Zoltán N OltvaiNat. Rev. Genet.200414735121No
80316511651.00.00.0The Michigan alcoholism screening test: the quest for a new diagnostic instrument. M L SelzerAm J Psychiatry19715565851Yes
80416511651.047.7747.8Negative refraction makes a perfect lens PendryPhys. Rev. Lett.200011041972Yes
80516511651.054.9655.0The episodic buffer: a new component of working memory? BaddeleyTrends Cogn. Sci. (Regul. Ed.)200011058819Yes
80632971648.575.9538.0Mammalian MAP kinase signalling cascades. L Chang, M KarinNature200111242034No
80716461646.044.4344.4Rab GTPases as coordinators of vesicle traffic. Harald StenmarkNat. Rev. Mol. Cell Biol.200919603039No
80816451645.046.0646.1Specification of cerebral cortical areas. P RakicScience19883291116No
80916441644.080.5380.5The Resonating Valence Bond State in La2CuO4 and Superconductivity. P W AndersonScience198717818979Yes
81032861643.078.3239.2Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. M Gossen, H BujardProc. Natl. Acad. Sci. U.S.A.19921319065Yes
81116401640.040.2740.3XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. D E McReeJ. Struct. Biol.199910222271Yes
81216391639.037.4737.5CpG motifs in bacterial DNA and their immune effects. Arthur M KriegAnnu. Rev. Immunol.200211861616No
81349151638.3149.0849.7GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. R A Jefferson, T A Kavanagh, M W BevanEMBO J.19873327686Yes
81449151638.3132.244.1MOLMOL: a program for display and analysis of macromolecular structures. R Koradi, M Billeter, K WüthrichJ Mol Graph19968744573Yes
81532761638.00.00.0Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid. A C Chang, S N CohenJ. Bacteriol.1978149110Yes
81616381638.00.00.0Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. F F JöbsisScience1977929199Yes
81716361636.045.3145.3Inferring the historical patterns of biological evolution. M PagelNature199910553904Yes
81849061635.3238.4179.5Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. G Muyzer, E C de Waal, A G UitterlindenAppl. Environ. Microbiol.19937683183Yes
81916351635.055.3355.3A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. P ChomczynskiBioTechniques19937692896Yes
82016351635.00.00.0A GENERALIZED WILCOXON TEST FOR COMPARING ARBITRARILY SINGLY-CENSORED SAMPLES. E A GEHANBiometrika196514341275Yes
82116311631.047.0847.1RGD and other recognition sequences for integrins. E RuoslahtiAnnu. Rev. Cell Dev. Biol.19968970741No
82248861628.7181.2360.4Arlequin (version 3.0): an integrated software package for population genetics data analysis. Laurent Excoffier, Guillaume Laval, Stefan SchneiderEvol. Bioinform. Online200719325852Yes
82316281628.077.4677.5International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results. C HerrmannJ Psychosom Res19979055211No
82497671627.8244.3640.7NMRPipe: a multidimensional spectral processing system based on UNIX pipes. F Delaglio, S Grzesiek, G W Vuister, G Zhu, J Pfeifer, A BaxJ. Biomol. NMR19958520220Yes
82532511625.50.00.0A diagnostic interview: the schedule for affective disorders and schizophrenia. J Endicott, R L SpitzerArch. Gen. Psychiatry1978678037Yes
82632491624.589.8144.9Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. B A Reynolds, S WeissScience19921553558Yes
82764941623.5282.1270.5A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. Stefan Grimme, Jens Antony, Stephan Ehrlich, Helge KriegJ Chem Phys201020423165Yes
82816231623.047.0547.0Protein kinase C and lipid signaling for sustained cellular responses. Y NishizukaFASEB J.19957737456No
82932441622.0140.9870.5The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. S H Downs, N BlackJ Epidemiol Community Health19989764259Yes
83032421621.093.8846.9Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Hashem B El-Serag, K Lenhard RudolphGastroenterology200717570226No
83116201620.00.00.0Diffusion-in-gel methods for immunological analysis. O OUCHTERLONYProg Allergy195813578996Yes
83216201620.054.7854.8Pancreatic cancer. Manuel HidalgoN. Engl. J. Med.201020427809No
83348571619.0128.5742.9A new statistical method for haplotype reconstruction from population data. M Stephens, N J Smith, P DonnellyAm. J. Hum. Genet.200111254454Yes
83464711617.8161.740.4Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. A Krogh, B Larsson, G von Heijne, E L SonnhammerJ. Mol. Biol.200111152613Yes
83548431614.3268.7689.6Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. J L Cox, J M Holden, R SagovskyBr J Psychiatry19873651732Yes
83632281614.0108.2654.1A simple and very efficient method for generating cDNA libraries. U Gubler, B J HoffmanGene19836198242Yes
83796821613.7323.3453.9A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. A S Levey, J P Bosch, J B Lewis, T Greene, N Rogers, D RothAnn. Intern. Med.199910075613Yes
83816131613.031.4631.5ATM and related protein kinases: safeguarding genome integrity. Yosef ShilohNat. Rev. Cancer200312612651No
83916111611.083.4983.5A systematic method for clinical description and classification of personality variants. A proposal. C R CloningerArch. Gen. Psychiatry19873579504Yes
84016111611.00.00.0Stereochemistry of cooperative effects in haemoglobin. M F PerutzNature19705528785Yes
84116111611.00.00.0Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli. G BERTANIJ. Bacteriol.195114888646Yes
842128851610.6527.8566.0The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C SiebertN. Engl. J. Med.19938366922Yes
84332171608.597.5548.8Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. M Nei, T GojoboriMol. Biol. Evol.19863444411Yes
84448231607.70.00.0ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL. J MONOD, J WYMAN, J P CHANGEUXJ. Mol. Biol.196514343300Yes
84516071607.045.3945.4The inflammatory reflex. Kevin J TraceyNature200212490958No
84648201606.7176.6158.9Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. C E Murry, R B Jennings, K A ReimerCirculation19863769170Yes
84732121606.092.7546.4Myeloid-derived suppressor cells as regulators of the immune system. Dmitry I Gabrilovich, Srinivas NagarajNat. Rev. Immunol.200919197294No
84816041604.057.4157.4Hybrid porous solids: past, present, future. Gérard FéreyChem Soc Rev200818197340Yes
84916021602.059.7359.7Calbindin D-28k and parvalbumin in the rat nervous system. M R CelioNeuroscience19902199841Yes
85016011601.082.7482.7Role of Streptococcus mutans in human dental decay. W J LoescheMicrobiol. Rev.19863540569No
85116011601.068.568.5Spinal and supraspinal factors in human muscle fatigue. S C GandeviaPhysiol. Rev.200111581501No
85232011600.598.0149.0Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. M Matsuda, R A DeFronzoDiabetes Care199910480510Yes
85316001600.037.5537.5Molecular bases for circadian clocks. J C DunlapCell19999988221No
85415991599.049.3349.3Working memory: looking back and looking forward. Alan BaddeleyNat. Rev. Neurosci.200314523382No
85595891598.22309.53384.9Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin JemalCA Cancer J Clin201830207593Yes
85647941598.0186.5762.2Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. L Excoffier, P E Smouse, J M QuattroGenetics19921644282Yes
85715971597.00.00.0Analysis of bacteriophage T7 early RNAs and proteins on slab gels. F W StudierJ. Mol. Biol.19734760132Yes
85831941597.00.00.0Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. J V Durnin, J WomersleyBr. J. Nutr.19744843734Yes
85915971597.053.5553.5Efficient methods to compute genomic predictions. P M VanRadenJ. Dairy Sci.200818946147Yes
86015951595.039.3339.3Nitric oxide and the immune response. C BogdanNat. Immunol.200111577346No
86131871593.5101.0650.5Application of phylogenetic networks in evolutionary studies. Daniel H Huson, David BryantMol. Biol. Evol.200616221896Yes
86231801590.0125.2262.6A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. G J Bennett, Y K XiePain19882837713Yes
86315901590.00.00.0Transplacental carcinogenesis by stilbestrol. J FolkmanN. Engl. J. Med.19715556579Yes
86431801590.098.6449.3Function and activation of NF-kappa B in the immune system. P A Baeuerle, T HenkelAnnu. Rev. Immunol.19948011280No
86531751587.5141.3470.7The attention system of the human brain. M I Posner, S E PetersenAnnu. Rev. Neurosci.19902183676No
86647601586.7108.7936.3EMBOSS: the European Molecular Biology Open Software Suite. P Rice, I Longden, A BleasbyTrends Genet.200010827456Yes
86731731586.5128.6964.3Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. R M Ryan, E L DeciAm Psychol200011392867Yes
86831711585.588.0444.0The acute respiratory distress syndrome. L B Ware, M A MatthayN. Engl. J. Med.200010793167No
86931701585.0113.4456.7Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. J S Beckman, W H KoppenolAm. J. Physiol.19968944624No
87015821582.031.1931.2Mechanisms of alternative pre-messenger RNA splicing. Douglas L BlackAnnu. Rev. Biochem.200312626338No
87147451581.7178.2659.4Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. C Lord, M Rutter, A Le CouteurJ Autism Dev Disord19947814313Yes
87231631581.50.00.0High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. M N Berry, D S FriendJ. Cell Biol.19694900611Yes
87331621581.0194.8997.4Stress, social support, and the buffering hypothesis. S Cohen, T A WillsPsychol Bull19853901065No
87431601580.082.1541.1Base-calling of automated sequencer traces using phred. II. Error probabilities. B Ewing, P GreenGenome Res.19989521922Yes
87531601580.069.6734.8The Wnt signaling pathway in development and disease. Catriona Y Logan, Roel NusseAnnu. Rev. Cell Dev. Biol.200415473860No
87615791579.054.4254.4Determination and analysis of urea and guanidine hydrochloride denaturation curves. C N PaceMeth. Enzymol.19863773761Yes
87715781578.034.0134.0In situ hybridization: an improved whole-mount method for Xenopus embryos. R M HarlandMethods Cell Biol.19911811161Yes
87815781578.045.0845.1The mitogen-activated protein kinase signal transduction pathway. R J DavisJ. Biol. Chem.19938325833No
87915781578.034.834.8Mechanisms of type-I- and type-II-interferon-mediated signalling. Leonidas C PlataniasNat. Rev. Immunol.200515864272No
88047331577.7219.1773.1Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Allison Tong, Peter Sainsbury, Jonathan CraigInt J Qual Health Care200717872937Yes
88115771577.053.3653.4Superoxide radical and superoxide dismutases. I FridovichAnnu. Rev. Biochem.19957574505No
88215771577.059.7559.8Fetal origins of coronary heart disease. D J BarkerBMJ19957613432No
88315771577.038.0438.0Mechanisms of intracellular protein transport. J E RothmanNature19947969419No
88415751575.034.7734.8Systems biology: a brief overview. Hiroaki KitanoScience200211872829No
88531491574.596.2648.1Regulation of the mevalonate pathway. J L Goldstein, M S BrownNature19901967820No
88615741574.036.3836.4Protein modules and signalling networks. T PawsonNature19957531822No
88715741574.069.8969.9Qualitative research: standards, challenges, and guidelines. K MalterudLancet200111513933Yes
88815731573.047.7847.8Mechanisms and genes of cellular suicide. H StellerScience19957878463No
88915731573.039.9139.9Defensins: antimicrobial peptides of innate immunity. Tomas GanzNat. Rev. Immunol.200312949495No
89015731573.036.2636.3The complex language of chromatin regulation during transcription. Shelley L BergerNature200717522673No
89131441572.00.00.0The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J A Spudich, S WattJ. Biol. Chem.19714254541Yes
89215691569.066.4366.4A classification of glycosyl hydrolases based on amino acid sequence similarities. B HenrissatBiochem. J.19911747104Yes
89315691569.045.8345.8The structure and regulation of protein phosphatases. P CohenAnnu. Rev. Biochem.19892549856No
89447041568.0139.5146.5Cortical surface-based analysis. I. Segmentation and surface reconstruction. A M Dale, B Fischl, M I SerenoNeuroimage19999931268Yes
89515671567.052.5852.6Patterns of amino acids near signal-sequence cleavage sites. G von HeijneEur. J. Biochem.19836852022Yes
89615671567.054.5854.6Stress, adaptation, and disease. Allostasis and allostatic load. B S McEwenAnn. N. Y. Acad. Sci.19989629234No
89715671567.036.8136.8The expanding role of mitochondria in apoptosis. X WangGenes Dev.200111711427No
89831311565.50.00.0Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. P J Fraker, J C SpeckBiochem. Biophys. Res. Commun.1978637870Yes
89931261563.0106.2853.1A receptor-mediated pathway for cholesterol homeostasis. M S Brown, J L GoldsteinScience19863513311No
90031251562.592.1246.1Leptin and the regulation of body weight in mammals. J M Friedman, J L HalaasNature19989796811No
90131251562.592.7146.4The endophenotype concept in psychiatry: etymology and strategic intentions. Irving I Gottesman, Todd D GouldAm J Psychiatry200312668349No
90231241562.083.0641.5The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. A J Ridley, A HallCell19921643657Yes
90315611561.046.0346.0Dopamine, learning and motivation. Roy A WiseNat. Rev. Neurosci.200415152198No
90431211560.569.0134.5Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. M Karin, Y Ben-NeriahAnnu. Rev. Immunol.200010837071No
90531111555.568.234.1Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Rudolf Jaenisch, Adrian BirdNat. Genet.200312610534No
90615551555.095.9295.9Structural Model Evaluation and Modification: An Interval Estimation Approach. J H SteigerMultivariate Behav Res199026794479Yes
90731091554.593.7246.9UniFrac: a new phylogenetic method for comparing microbial communities. Catherine Lozupone, Rob KnightAppl. Environ. Microbiol.200516332807Yes
90815541554.055.1555.1Formation and Structure of Self-Assembled Monolayers. Abraham UlmanChem. Rev.199611848802Yes
90931041552.0109.5154.8The number of people with glaucoma worldwide in 2010 and 2020. H A Quigley, A T BromanBr J Ophthalmol200616488940Yes
91015501550.035.3835.4Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. R J KaufmanGenes Dev.199910346810No
91115491549.061.861.8Eye movements in reading and information processing: 20 years of research. K RaynerPsychol Bull19989849112No
91215491549.036.236.2Metastasis to bone: causes, consequences and therapeutic opportunities. Gregory R MundyNat. Rev. Cancer200212154351No
91315491549.041.5741.6Pathways towards and away from Alzheimer's disease. Mark P MattsonNature200415295589No
91430921546.067.2133.6The fundamental role of epigenetic events in cancer. Peter A Jones, Stephen B BaylinNat. Rev. Genet.200212042769No
91515451545.060.9961.0An empirical correction for absorption anisotropy. R H BlessingActa Crystallogr., A, Found. Crystallogr.19957702794Yes
91615451545.00.00.0A RATIONALE AND TEST FOR THE NUMBER OF FACTORS IN FACTOR ANALYSIS. J L HORNPsychometrika196514306381Yes
91715451545.00.00.0The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. R R PORTERBiochem. J.195914434282Yes
91815441544.00.00.0Efficient trace-labelling of proteins with iodine. A S McFARLANENature195813566175Yes
91930851542.5182.7291.4Stages and processes of self-change of smoking: toward an integrative model of change. J O Prochaska, C C DiClementeJ Consult Clin Psychol19836863699Yes
92015421542.067.1667.2Human error: models and management. J ReasonBMJ200010720363Yes
92130831541.50.00.0Acetylornithinase of Escherichia coli: partial purification and some properties. H J VOGEL, D M BONNERJ. Biol. Chem.195613278318Yes
92215411541.044.3344.3Calcium signaling. D E ClaphamCell19957834745No
92315411541.048.9749.0Hepatitis B virus infection. W M LeeN. Engl. J. Med.19979392700No
92430811540.581.2340.6Brown adipose tissue: function and physiological significance. Barbara Cannon, Jan NedergaardPhysiol. Rev.200414715917No
92515401540.073.4673.5Specific impairments of planning. T ShallicePhilos. Trans. R. Soc. Lond., B, Biol. Sci.19826125971Yes
92615401540.047.3447.3Mechanisms of hepatic fibrogenesis. Scott L FriedmanGastroenterology200818471545No
92730771538.591.4245.7Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. P J Barnes, M KarinN. Engl. J. Med.19979091804No
92815371537.00.00.0The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. U E LoeningBiochem. J.19675339944Yes
92930741537.0116.4258.2SPSS and SAS procedures for estimating indirect effects in simple mediation models. Kristopher J Preacher, Andrew F HayesBehav Res Methods Instrum Comput200415641418Yes
93015351535.030.3130.3The regulation of E2F by pRB-family proteins. N DysonGenes Dev.19989694791No
93115351535.00.00.0Notes on sugar determination. M SMOGYIJ. Biol. Chem.195214938350Yes
93215341534.038.7738.8The immunopathogenesis of sepsis. Jonathan CohenNature200212490963No
93315341534.069.6769.7Epidemiology of viral hepatitis and hepatocellular carcinoma. Hashem B El-SeragGastroenterology201222537432No
93430661533.083.6441.8The future of genetic studies of complex human diseases. N Risch, K MerikangasScience19968801636Yes
93530651532.5104.1552.1A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Y Matsumura, H MaedaCancer Res.19862946403Yes
93630651532.589.1444.6Cutaneous wound healing. A J Singer, R A ClarkN. Engl. J. Med.199910471461No
93730651532.596.1848.1Protein structure prediction on the Web: a case study using the Phyre server. Lawrence A Kelley, Michael J E SternbergNat Protoc200919247286Yes
93815321532.034.434.4Signalling pathways of the TNF superfamily: a double-edged sword. Bharat B AggarwalNat. Rev. Immunol.200312949498No
93945911530.3137.1145.7ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Kai Wang, Mingyao Li, Hakon HakonarsonNucleic Acids Res.201020601685Yes
94015301530.063.963.9Plant products as antimicrobial agents. M M CowanClin. Microbiol. Rev.199910515903No
94115281528.045.7145.7Flow-mediated endothelial mechanotransduction. P F DaviesPhysiol. Rev.19957624393No
94215281528.00.00.0MECHANISM OF SUSTAINED-ACTION MEDICATION. THEORETICAL ANALYSIS OF RATE OF RELEASE OF SOLID DRUGS DISPERSED IN SOLID MATRICES. T HIGUCHIJ Pharm Sci196314088963Yes
94345831527.7150.2950.1Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. F E Harrell, K L Lee, D B MarkStat Med19968668867No
94430541527.067.9134.0Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Rik Derynck, Ying E ZhangNature200314534577No
94530471523.5101.0650.5Distributed hierarchical processing in the primate cerebral cortex. D J Felleman, D C Van EssenCereb. Cortex19911822724No
94615231523.052.2452.2The importance of selenium to human health. M P RaymanLancet200010963212No
94715221522.085.4285.4A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. E L BradleyArch Surg19938489394No
94815221522.040.0240.0Cellular mechanisms of insulin resistance. G I ShulmanJ. Clin. Invest.200010903330No
94930411520.563.431.7Rho GTPases in cell biology. Sandrine Etienne-Manneville, Alan HallNature200212478284No
95015201520.034.1934.2Approaching the asymptote? Evolution and revolution in immunology. C A JanewayCold Spring Harb. Symp. Quant. Biol.19892700931No
95115201520.00.00.0Evaluating the quality of medical care. A DonabedianMilbank Mem Fund Q19665338568No
95215181518.031.3231.3Signaling--2000 and beyond. T HunterCell200010647936No
95345521517.396.1132.0Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Jason D Fontenot, Marc A Gavin, Alexander Y RudenskyNat. Immunol.200312612578Yes
95445501516.7153.3751.1Immunity, inflammation, and cancer. Sergei I Grivennikov, Florian R Greten, Michael KarinCell201020303878No
95530321516.00.00.0Some quantitative uses of drug antagonists. O ARUNLAKSHANA, H O SCHILDBr J Pharmacol Chemother195913651579Yes
95615151515.037.5237.5Theta oscillations in the hippocampus. György BuzsákiNeuron200211832222No
95715151515.00.00.0On respiratory impairment in cancer cells. O WARBURGScience195613351639Yes
95815141514.084.7384.7The quality of care. How can it be assessed? A DonabedianJAMA19883045356No
95915131513.00.00.0Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. M J CasadabanJ. Mol. Biol.1976781293Yes
96015131513.037.2937.3TRP channels as cellular sensors. David E ClaphamNature200314654832No
96115121512.078.7778.8Predicting basal metabolic rate, new standards and review of previous work. W N SchofieldHum Nutr Clin Nutr19854044297Yes
96230211510.50.00.0On the size of the active site in proteases. I. Papain. I Schechter, A BergerBiochem. Biophys. Res. Commun.19676035483Yes
96315101510.065.4565.5Prooxidant states and tumor promotion. P A CeruttiScience19852981433No
96415091509.049.2549.2Bcl-2 and the regulation of programmed cell death. J C ReedJ. Cell Biol.19948294493No
96515091509.042.2942.3DAMPs, PAMPs and alarmins: all we need to know about danger. Marco E BianchiJ. Leukoc. Biol.200717032697No
96630161508.098.5249.3Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. P Liang, A B PardeeScience19921354393Yes
96715081508.060.4560.5ATP-regulated K+ channels in cardiac muscle. A NomaNature19836310409Yes
96845201506.7157.6752.6Quantum mechanical continuum solvation models. Jacopo Tomasi, Benedetta Mennucci, Roberto CammiChem. Rev.200516092826Yes
96915061506.00.00.0Protein denaturation. C TanfordAdv. Protein Chem.19684882248No
97015061506.082.4682.5Central sensitization: implications for the diagnosis and treatment of pain. Clifford J WoolfPain201120961685No
97115041504.084.0884.1The Children's Depression, Inventory (CDI). M KovacsPsychopharmacol Bull19854089116Yes
97260161504.0172.1243.0Matrix elasticity directs stem cell lineage specification. Adam J Engler, Shamik Sen, H Lee Sweeney, Dennis E DischerCell200616923388Yes
97345061502.0119.539.8APE: Analyses of Phylogenetics and Evolution in R language. Emmanuel Paradis, Julien Claude, Korbinian StrimmerBioinformatics200414734327Yes
97430021501.00.00.0A SIMPLIFIED LEAD CITRATE STAIN FOR USE IN ELECTRON MICROSCOPY. J H VENABLE, R COGGESHALLJ. Cell Biol.196514287192Yes
97515011501.054.0354.0Parkinson's disease: clinical features and diagnosis. J JankovicJ. Neurol. Neurosurg. Psychiatry200818344392No
97615001500.057.0557.0Inhibited spontaneous emission in solid-state physics and electronics. YablonovitchPhys. Rev. Lett.198710034639Yes
97729981499.00.00.0Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. R B Devereux, N ReichekCirculation1977138494Yes
97814981498.062.9462.9The use of a plus-maze to measure anxiety in the mouse. R G ListerPsychopharmacology (Berl.)19873110839Yes
97914971497.051.1551.1Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Claudiu T SupuranNat Rev Drug Discov200818167490No
98014961496.00.00.0Removal of fatty acids from serum albumin by charcoal treatment. R F ChenJ. Biol. Chem.19676016603Yes
98144871495.7175.5958.5Cell death: the significance of apoptosis. A H Wyllie, J F Kerr, A R CurrieInt. Rev. Cytol.19807014501No
98229901495.070.4935.2Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. C D Nobes, A HallCell19957536630Yes
98314951495.042.7642.8Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. G TrinchieriAnnu. Rev. Immunol.19957612223No
98414941494.070.2370.2Determination of glutathione and glutathione disulfide in biological samples. M E AndersonMeth. Enzymol.19854088074Yes
985104581494.0266.5838.1Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank SpelemanGenome Biol.200212184808Yes
98614941494.042.1442.1The global health burden of infection-associated cancers in the year 2002. Donald Maxwell ParkinInt. J. Cancer200616404738Yes
98714931493.076.2676.3Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. B N AmesScience19836351251No
98814931493.038.2938.3Neutrophils and immunity: challenges and opportunities. Carl NathanNat. Rev. Immunol.200616498448No
98944731491.0163.1954.4The brain's default network: anatomy, function, and relevance to disease. Randy L Buckner, Jessica R Andrews-Hanna, Daniel L SchacterAnn. N. Y. Acad. Sci.200818400922No
99014901490.078.6678.7Calmodulin plays a pivotal role in cellular regulation. W Y CheungScience19806243188No
99159571489.2164.7741.2Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. A Shevchenko, M Wilm, O Vorm, M MannAnal. Chem.19968779443Yes
99214891489.033.3633.4Antiviral actions of interferons. C E SamuelClin. Microbiol. Rev.200111585785No
99314881488.00.00.0Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. O SMITHIESBiochem. J.195513276348Yes
99429751487.50.00.0Loss of recent memory after bilateral hippocampal lesions. W B SCOVILLE, B MILNERJ. Neurol. Neurosurg. Psychiatry195713406589Yes
99514871487.042.2942.3Evolutionary relationship of DNA sequences in finite populations. F TajimaGenetics19836628982Yes
99629721486.072.6736.3Lessons from hereditary colorectal cancer. K W Kinzler, B VogelsteinCell19968861899No
99714851485.048.3448.3The molecular pathology of Alzheimer's disease. D J SelkoeNeuron19911673054No
99829701485.00.00.0A complementation analysis of the restriction and modification of DNA in Escherichia coli. H W Boyer, D Roulland-DussoixJ. Mol. Biol.19694896022Yes
99914851485.00.00.0Analysis of tissue and arterial blood temperatures in the resting human forearm. H H PENNESJ Appl Physiol194818887578Yes
100014841484.047.9548.0The physiology of glucagon-like peptide 1. Jens Juul HolstPhysiol. Rev.200717928588No
100114831483.064.4664.5Simplified calculation of body-surface area. R D MostellerN. Engl. J. Med.19873657876Yes
100214831483.044.7744.8Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Fiona TurnbullLancet200314615107Yes
100314821482.00.00.0The catecholamine hypothesis of affective disorders: a review of supporting evidence. J J SchildkrautAm J Psychiatry19655319766No
100414821482.047.847.8The blood-brain barrier in health and chronic neurodegenerative disorders. Berislav V ZlokovicNeuron200818215617No
100514781478.035.7835.8Thrombin signalling and protease-activated receptors. S R CoughlinNature200011001069No
100614761476.035.9936.0Exploring complex networks. S H StrogatzNature200111258382No
100714761476.064.4664.5Health consequences of intimate partner violence. Jacquelyn C CampbellLancet200211965295No
100814731473.055.6355.6Protein oxidation and aging. E R StadtmanScience19921355616No
100914731473.032.4232.4MicroRNA biogenesis: coordinated cropping and dicing. V Narry KimNat. Rev. Mol. Cell Biol.200515852042No
101014731473.097.8697.9Interrater reliability: the kappa statistic. Mary L McHughBiochem Med (Zagreb)201223092060Yes
101114721472.035.8135.8Structure and regulation of voltage-gated Ca2+ channels. W A CatterallAnnu. Rev. Cell Dev. Biol.200011031246No
101214721472.031.6631.7Notch signalling: a simple pathway becomes complex. Sarah J BrayNat. Rev. Mol. Cell Biol.200616921404No
101314711471.00.00.0Inositol phospholipids and cell surface receptor function. R H MichellBiochim. Biophys. Acta1975164246No
101414691469.040.7140.7Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Jeffrey A EngelmanNat. Rev. Cancer200919629070No
101529341467.096.148.0The heat-shock proteins. S Lindquist, E A CraigAnnu. Rev. Genet.19882853609No
101614671467.035.5835.6Developmental regulation of the growth plate. Henry M KronenbergNature200312748651No
101714651465.00.00.0The plasma lecithins:cholesterol acyltransferase reaction. J A GlomsetJ. Lipid Res.19684868699No
101829301465.0168.9884.5The Brief Symptom Inventory: an introductory report. L R Derogatis, N MelisaratosPsychol Med19836622612Yes
101914641464.075.4875.5Missing data analysis: making it work in the real world. John W GrahamAnnu Rev Psychol200918652544No
102014631463.053.5153.5Excitotoxic cell death. D W ChoiJ. Neurobiol.19921361523No
102114631463.040.5140.5Global cancer statistics in the year 2000. D M ParkinLancet Oncol.200111905707No
102214621462.047.347.3Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Gökhan S HotamisligilCell201020303879No
102314611461.040.0640.1Type III protein secretion systems in bacterial pathogens of animals and plants. C J HueckMicrobiol. Mol. Biol. Rev.19989618447No
102414611461.032.7632.8DNA topoisomerases: structure, function, and mechanism. J J ChampouxAnnu. Rev. Biochem.200111395412No
102543831461.0112.6837.6Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Michael W Pfaffl, Graham W Horgan, Leo DempfleNucleic Acids Res.200211972351Yes
102614611461.047.3247.3Accurate description of van der Waals complexes by density functional theory including empirical corrections. Stefan GrimmeJ Comput Chem200415224390Yes
102758371459.2272.2868.1The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. T F Heatherton, L T Kozlowski, R C Frecker, K O FagerströmBr J Addict19911932883Yes
102829181459.084.3442.2A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. G Shaw, R KamenCell19863488815Yes
102929161458.071.1335.6Cell death: critical control points. Nika N Danial, Stanley J KorsmeyerCell200414744432No
103014581458.058.0558.0The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Claudio HetzNat. Rev. Mol. Cell Biol.201222251901No
103143731457.70.00.0Glucose clamp technique: a method for quantifying insulin secretion and resistance. R A DeFronzo, J D Tobin, R AndresAm. J. Physiol.1979382871Yes
103214571457.047.3147.3Epidemiology of insomnia: what we know and what we still need to learn. Maurice M OhayonSleep Med Rev200212531146Yes
103314561456.084.9685.0Detecting alcoholism. The CAGE questionnaire. J A EwingJAMA19846471323Yes
103414551455.051.6551.6Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. A DunaifEndocr. Rev.19979408743No
103558201455.0133.4933.4WebLogo: a sequence logo generator. Gavin E Crooks, Gary Hon, John-Marc Chandonia, Steven E BrennerGenome Res.200415173120Yes
103629071453.590.5645.3Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. G G Glenner, C W WongBiochem. Biophys. Res. Commun.19846375662Yes
103714531453.00.00.0Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? J V NEELAm. J. Hum. Genet.196213937884Yes
103843571452.30.00.0Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. B N Ames, J Mccann, E YamasakiMutat. Res.1975768755Yes
103914521452.038.1438.1A clearer vision for in vivo imaging. R WeisslederNat. Biotechnol.200111283581No
104043551451.7176.8859.0Parallel organization of functionally segregated circuits linking basal ganglia and cortex. G E Alexander, M R DeLong, P L StrickAnnu. Rev. Neurosci.19863085570No
104129001450.097.6148.8Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. K D McCarthy, J de VellisJ. Cell Biol.19806248568Yes
104214481448.071.2371.2Why patients use alternative medicine: results of a national study. J A AstinJAMA19989605899Yes
104314471447.041.8741.9Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. D LavanchyJ. Viral Hepat.200414996343No
104414471447.045.245.2T cell exhaustion. E John WherryNat. Immunol.201121739672No
104514461446.044.2544.2Breast cancer and hormone-replacement therapy in the Million Women Study. Valerie BeralLancet200312927427Yes
104628891444.577.5338.8CAP3: A DNA sequence assembly program. X Huang, A MadanGenome Res.199910508846Yes
104714441444.030.8230.8CD4+ CD25+ suppressor T cells: more questions than answers. Ethan M ShevachNat. Rev. Immunol.200212093005No
104814431443.00.00.0Oxygen-dependent microbial killing by phagocytes (first of two parts). B M BabiorN. Engl. J. Med.197824176Yes
104928861443.00.00.0Mathematical model for studying genetic variation in terms of restriction endonucleases. M Nei, W H LiProc. Natl. Acad. Sci. U.S.A.1979291943Yes
105028851442.591.2245.6Assembly of asparagine-linked oligosaccharides. R Kornfeld, S KornfeldAnnu. Rev. Biochem.19853896128No
105114421442.051.3251.3Genetic differentiation and estimation of gene flow from F-statistics under isolation by distance. F RoussetGenetics19979093870Yes
105214421442.035.9636.0A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics. J SantaLuciaProc. Natl. Acad. Sci. U.S.A.19989465037Yes
105314411441.00.00.0Mechanisms of action of transmitters and other substances on smooth muscle. T B BoltonPhysiol. Rev.197937533No
105414411441.00.00.0Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry. M Wong-RileyBrain Res.1979223730Yes
105514391439.053.4653.5A measure of population subdivision based on microsatellite allele frequencies. M SlatkinGenetics19957705646Yes
105614371437.067.1767.2Heavy metal intensification of DAB-based HRP reaction product. J C AdamsJ. Histochem. Cytochem.19817252134Yes
105728691434.50.00.0A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. R F BEERS, I W SIZERJ. Biol. Chem.195214938361Yes
105814321432.041.9742.0Cancer chemoprevention with dietary phytochemicals. Young-Joon SurhNat. Rev. Cancer200314570043No
105928641432.082.0941.0Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Michael T Lin, M Flint BealNature200617051205No
106014311431.060.0160.0Epidemiological features of chronic low-back pain. G B AnderssonLancet199910470716No
106114301430.044.2844.3Signal sequences. The limits of variation. G von HeijneJ. Mol. Biol.19854032478Yes
106214291429.00.00.0SELECTION OF HYBRIDS FROM MATINGS OF FIBROBLASTS IN VITRO AND THEIR PRESUMED RECOMBINANTS. J W LITTLEFIELDScience196414168277Yes
106314291429.047.3947.4A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data. Heng LiBioinformatics201121903627Yes
106414281428.039.6539.6Metabolomics--the link between genotypes and phenotypes. Oliver FiehnPlant Mol. Biol.200211860207No
106528551427.50.00.0Judgment under Uncertainty: Heuristics and Biases. A Tversky, D KahnemanScience197417835457Yes
106614271427.0102.39102.4Determination and quantification of content validity. M R LynnNurs Res19863640358Yes
106714261426.037.9237.9Chemokines. B J RollinsBlood19979242519No
106899651423.6268.7638.4Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya YamanakaCell200718035408Yes
106928471423.5162.8281.4The Health Belief Model: a decade later. N K Janz, M H BeckerHealth Educ Q19846392204No
107042701423.3181.0860.4AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. P G Reeves, F H Nielsen, G C FaheyJ. Nutr.19938229312No
107114231423.057.8257.8Diagnosis of Alzheimer's disease. Z S KhachaturianArch. Neurol.19852864910Yes
107214231423.029.9730.0Generating samples under a Wright-Fisher neutral model of genetic variation. Richard R HudsonBioinformatics200211847089Yes
107314211421.043.043.0Follicular helper CD4 T cells (TFH). Shane CrottyAnnu. Rev. Immunol.201121314428No
107414171417.061.5461.5DNA methylation age of human tissues and cell types. Steve HorvathGenome Biol.201324138928Yes
107514151415.00.00.0Presidential Address-1976. Social support as a moderator of life stress. S CobbPsychosom Med1976981490Yes
107614151415.028.9629.0Maximum-likelihood density modification. T C TerwilligerActa Crystallogr. D Biol. Crystallogr.200010944333Yes
107728281414.0123.9662.0Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. M H Zweig, G CampbellClin. Chem.19938472349No
107814141414.043.3943.4Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. R D Pascual-MarquiMethods Find Exp Clin Pharmacol200212575463No
107970661413.2228.0545.6Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Sarah Wild, Gojka Roglic, Anders Green, Richard Sicree, Hilary KingDiabetes Care200415111519Yes
108070661413.2199.3939.9Mapping and quantifying mammalian transcriptomes by RNA-Seq. Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer, Barbara WoldNat. Methods200818516045Yes
108114131413.056.0756.1Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. R A DeFronzoDiabetes19883289989No
108228241412.00.00.0An efficient mRNA-dependent translation system from reticulocyte lysates. H R Pelham, R J JacksonEur. J. Biochem.1976823012Yes
108314111411.00.00.0Towards a network theory of the immune system. N K JerneAnn. Immunol. (Paris)19744142565No
108414111411.052.4352.4The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. G P ChrousosN. Engl. J. Med.19957715646No
108528211410.579.7939.9Measuring the thickness of the human cerebral cortex from magnetic resonance images. B Fischl, A M DaleProc. Natl. Acad. Sci. U.S.A.200010984517Yes
108614091409.060.3760.4Keratoconus. Y S RabinowitzSurv Ophthalmol19989493273No
108728171408.568.8634.4Monocyte and macrophage heterogeneity. Siamon Gordon, Philip R TaylorNat. Rev. Immunol.200516322748No
108814081408.00.00.0A classification of hand preference by association analysis. M AnnettBr J Psychol19705457503Yes
108928131406.573.5336.8Identification of common molecular subsequences. T F Smith, M S WatermanJ. Mol. Biol.19817265238Yes
109014051405.061.0861.1Physiological actions of taurine. R J HuxtablePhysiol. Rev.19921731369No
109156161404.0282.0670.5A simple technique for quantitation of low levels of DNA damage in individual cells. N P Singh, M T McCoy, R R Tice, E L SchneiderExp. Cell Res.19883345800Yes
109214041404.047.747.7Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. J FolkmanN. Engl. J. Med.19957491141No
109342081402.7127.7942.6Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. G S Hotamisligil, N S Shargill, B M SpiegelmanScience19937678183Yes
109428051402.50.00.0PREPARATION OF FATTY ACID METHYL ESTERS AND DIMETHYLACETALS FROM LIPIDS WITH BORON FLUORIDE--METHANOL. W R MORRISON, L M SMITHJ. Lipid Res.196414221106Yes
109514021402.037.8337.8The synaptic vesicle cycle: a cascade of protein-protein interactions. T C SüdhofNature19957791897No
109614011401.035.8135.8Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. S L FriedmanJ. Biol. Chem.200010644669No
109741991399.790.0630.0Surfing the p53 network. B Vogelstein, D Lane, A J LevineNature200011099028No
109841941398.0120.2640.1Rapid and efficient site-specific mutagenesis without phenotypic selection. T A Kunkel, J D Roberts, R A ZakourMeth. Enzymol.19873323813Yes
109913981398.045.0445.0Thioredoxin. A HolmgrenAnnu. Rev. Biochem.19853896121No
110013981398.040.3640.4Inflammatory bowel disease: etiology and pathogenesis. C FiocchiGastroenterology19989649475No
110127941397.088.544.2Alzheimer's disease: the amyloid cascade hypothesis. J A Hardy, G A HigginsScience19921566067No
110213961396.037.6837.7G1 events and regulation of cell proliferation. A B PardeeScience19892683075No
110355841396.0144.8336.2Transformation of intact yeast cells treated with alkali cations. H Ito, Y Fukuda, K Murata, A KimuraJ. Bacteriol.19836336730Yes
110413951395.00.00.0Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. J P ChamberlainAnal. Biochem.1979543547Yes
110513951395.056.1356.1Archaea in coastal marine environments. E F DeLongProc. Natl. Acad. Sci. U.S.A.19921608980Yes
110613951395.058.1458.1Social cognitive theory: an agentic perspective. A BanduraAnnu Rev Psychol200111148297Yes
110727891394.584.5642.3Receptors for purines and pyrimidines. V Ralevic, G BurnstockPharmacol. Rev.19989755289No
110813941394.031.4831.5The synaptic vesicle cycle. Thomas C SudhofAnnu. Rev. Neurosci.200415217342No
110913931393.032.8532.9Molecular regulation of vessel maturation. Rakesh K JainNat. Med.200312778167No
111013931393.037.4837.5Integrating cell-signalling pathways with NF-kappaB and IKK function. Neil D PerkinsNat. Rev. Mol. Cell Biol.200717183360No
111155641391.0228.7857.2Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. A J Hughes, S E Daniel, L Kilford, A J LeesJ. Neurol. Neurosurg. Psychiatry19921564476Yes
111227811390.50.00.0Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. I W McLean, P K NakaneJ. Histochem. Cytochem.19744374474Yes
111313901390.00.00.0The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. D E AtkinsonBiochemistry19684972613Yes
111427781389.083.9942.0Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering Nie, EmoryScience19979027306Yes
111527761388.0108.8254.4Angiogenic factors. J Folkman, M KlagsbrunScience19872432664No
111613881388.044.0244.0Interleukin-2: inception, impact, and implications. K A SmithScience19883131876No
111713881388.032.832.8Protein homology detection by HMM-HMM comparison. Johannes SödingBioinformatics200515531603Yes
111827701385.073.2336.6Protein structure comparison by alignment of distance matrices. L Holm, C SanderJ. Mol. Biol.19938377180Yes
111913851385.029.1529.1Cellular roles of DNA topoisomerases: a molecular perspective. James C WangNat. Rev. Mol. Cell Biol.200212042765No
112027701385.070.6335.3Raster3D: photorealistic molecular graphics. E A Merritt, D J BaconMeth. Enzymol.199718488322Yes
112127681384.0108.3954.2Efficient pseudopotentials for plane-wave calculations. Troullier, MartinsPhys. Rev., B Condens. Matter19919997467Yes
112213831383.036.0936.1The distribution of secondary growths in cancer of the breast. 1889. S PagetCancer Metastasis Rev.19892673568No
112313831383.040.8640.9Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Scott L FriedmanPhysiol. Rev.200818195085No
112413821382.034.0534.0Excitatory actions of gaba during development: the nature of the nurture. Yehezkel Ben-AriNat. Rev. Neurosci.200212209121No
112513811381.038.2638.3Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. S A BustinJ. Mol. Endocrinol.200212200227No
112627601380.0117.3758.7Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. G Di Chiara, A ImperatoProc. Natl. Acad. Sci. U.S.A.19882899326Yes
112713801380.042.9242.9The extracellular matrix: not just pretty fibrils. Richard O HynesScience200919965464No
112813781378.034.134.1Bone morphogenetic proteins: multifunctional regulators of vertebrate development. B L HoganGenes Dev.19968682290No
112913771377.053.8953.9Interleukin-1 and interleukin-1 antagonism. C A DinarelloBlood19911826616No
113013771377.043.0143.0What is cognitive reserve? Theory and research application of the reserve concept. Yaakov SternJ Int Neuropsychol Soc200211939702No
113155061376.5119.4229.9Stem cells, cancer, and cancer stem cells. T Reya, S J Morrison, M F Clarke, I L WeissmanNature200111689955No
113227531376.5118.4959.2FLASH: fast length adjustment of short reads to improve genome assemblies. Tanja Magoč, Steven L SalzbergBioinformatics201121903629Yes
113327461373.0154.0477.0The MOS social support survey. C D Sherbourne, A L StewartSoc Sci Med19912035047Yes
113413731373.071.9872.0Approximate entropy as a measure of system complexity. S M PincusProc. Natl. Acad. Sci. U.S.A.199111607165Yes
113513731373.052.1152.1TGFβ signalling in context. Joan MassaguéNat. Rev. Mol. Cell Biol.201222992590No
113613721372.077.0277.0A rating scale for drug-induced akathisia. T R BarnesBr J Psychiatry19892574607Yes
113713711371.00.00.0Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. P MitchellBiol Rev Camb Philos Soc19665329743No
113813711371.031.5131.5The effect of infections on susceptibility to autoimmune and allergic diseases. Jean-Francois BachN. Engl. J. Med.200212239261No
113913701370.00.00.0The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. G S ManningQ. Rev. Biophys.1978353876No
114041071369.0113.7837.9Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. A Nicholls, K A Sharp, B HonigProteins19911758883Yes
114113691369.055.455.4Sick individuals and sick populations. G RoseInt J Epidemiol19853872850Yes
114227381369.00.00.0Variations in pattern of pubertal changes in girls. W A Marshall, J M TannerArch. Dis. Child.19695785179Yes
114327381369.094.847.4Insulin-like growth factors and their binding proteins: biological actions. J I Jones, D R ClemmonsEndocr. Rev.19957758431No
1144123181368.71055.99117.3Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie BrayInt. J. Cancer201525220842Yes
114513671367.00.00.0Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. E M WitkinBacteriol Rev1976795416No
114627311365.5100.5150.3Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. B J Marshall, J R WarrenLancet19846145023Yes
114727311365.586.3543.2The mirror-neuron system. Giacomo Rizzolatti, Laila CraigheroAnnu. Rev. Neurosci.200415217330No
114813651365.040.2140.2The dawning era of polymer therapeutics. Ruth DuncanNat Rev Drug Discov200312750738No
114913641364.00.00.0Stereotaxic mapping of the monoamine pathways in the rat brain. U UngerstedtActa Physiol Scand Suppl19714109331Yes
115013631363.033.5733.6Neuronal calcium signaling. M J BerridgeNeuron19989697848No
115113631363.042.4742.5THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons. Kozi AsadaAnnu. Rev. Plant Physiol. Plant Mol. Biol.199915012221Yes
115227221361.074.6737.3Amino acid substitution matrices from protein blocks. S Henikoff, J G HenikoffProc. Natl. Acad. Sci. U.S.A.19921438297Yes
115313611361.062.262.2Recognition-by-components: a theory of human image understanding. Irving BiedermanPsychol Rev19873575582Yes
115427181359.00.00.0Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. J G Rheinwald, H GreenCell19751052771Yes
115513591359.080.1280.1Role of endothelium in responses of vascular smooth muscle. R F FurchgottCirc. Res.19836313250No
115627181359.081.1540.6Matrix metalloproteinases. H Nagase, J F WoessnerJ. Biol. Chem.199910419448No
115713581358.042.3842.4Neurotrophins and neuronal plasticity. H ThoenenScience19957570017No
115813581358.040.4740.5Interfaces and the driving force of hydrophobic assembly. David ChandlerNature200516193038No
115927151357.5118.4359.2Oxygen toxicity, oxygen radicals, transition metals and disease. B Halliwell, J M GutteridgeBiochem. J.19846326753No
116013571357.00.00.0Dendritic organization in the neurons of the visual and motor cortices of the cat. D A SHOLLJ. Anat.195313117757Yes
116127131356.566.333.1Integrin signaling. F G Giancotti, E RuoslahtiScience199910446041No
116240681356.0165.655.2Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. R L Spitzer, K Kroenke, J B WilliamsJAMA199910568646Yes
116313561356.039.8539.9Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Paul M RidkerCirculation200312551853No
116413551355.058.5458.5Drugs of abuse: anatomy, pharmacology and function of reward pathways. G F KoobTrends Pharmacol. Sci.19921604710No
116554201355.0163.0740.8Epithelial-mesenchymal transitions in development and disease. Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang, M Angela NietoCell200919945376No
116613541354.00.00.0Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. A BreslowAnn. Surg.19705477666Yes
116713521352.083.2283.2Performance-oriented assessment of mobility problems in elderly patients. M E TinettiJ Am Geriatr Soc19863944402Yes
116813511351.030.3730.4DNA methylation and human disease. Keith D RobertsonNat. Rev. Genet.200516136652No
116913501350.00.00.0Positional information and the spatial pattern of cellular differentiation. L WolpertJ. Theor. Biol.19694390734Yes
117013501350.00.00.0Purinergic nerves. G BurnstockPharmacol. Rev.19724404211No
117113501350.00.00.0Pedigrees of some mutant strains of Escherichia coli K-12. B J BachmannBacteriol Rev19724568763No
117226991349.585.0442.5Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. Steven E Nissen, Kathy WolskiN. Engl. J. Med.200717517853Yes
117313491349.043.743.7Chlorpromazine equivalent doses for the newer atypical antipsychotics. Scott W WoodsJ Clin Psychiatry200312823080No
117413491349.00.00.0A study of the adrenotropic receptors. R P AHLQUISTAm. J. Physiol.194818882199Yes
117526951347.586.1243.1Cloned glutamate receptors. M Hollmann, S HeinemannAnnu. Rev. Neurosci.19948210177No
117626951347.50.00.0Genetic regulatory mechanisms in the synthesis of proteins. F JACOB, J MONODJ. Mol. Biol.196113718526Yes
117713471347.039.4239.4A theory of cortical responses. Karl FristonPhilos. Trans. R. Soc. Lond., B, Biol. Sci.200515937014No
117826931346.598.0649.0New perspectives in cell adhesion: RGD and integrins. E Ruoslahti, M D PierschbacherScience19872821619No
117913461346.035.9736.0Animal mitochondrial genomes. J L BooreNucleic Acids Res.199910101183No
118013451345.00.00.0A theory of cerebellar cortex. D MarrJ. Physiol. (Lond.)19695784296Yes
118113421342.029.1329.1Network motifs: theory and experimental approaches. Uri AlonNat. Rev. Genet.200717510665No
118293751339.3433.2861.9Assessing the quality of reports of randomized clinical trials: is blinding necessary? A R Jadad, R A Moore, D Carroll, C Jenkinson, D J Reynolds, D J Gavaghan, H J McQuayControl Clin Trials19968721797Yes
118313391339.096.1196.1The assessment of clinical skills/competence/performance. G E MillerAcad Med19902400509Yes
118413381338.036.4736.5Getting formal with dopamine and reward. Wolfram SchultzNeuron200212383780No
118513381338.028.6228.6The microRNA Registry. Sam Griffiths-JonesNucleic Acids Res.200414681370Yes
118613361336.068.2368.2Reliability and validity studies of the WHO--Composite International Diagnostic Interview (CIDI): a critical review. H U WittchenJ Psychiatr Res19948064641No
118713361336.040.0640.1The genetics of ageing. Cynthia J KenyonNature201020336132No
118826711335.5147.5573.8miRBase: annotating high confidence microRNAs using deep sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res.201424275495Yes
118913351335.045.4845.5Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. Robert E MarxJ. Oral Maxillofac. Surg.200312966493Yes
119026691334.582.5541.3Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. P J Southern, P BergJ. Mol. Appl. Genet.19826286831Yes
119113341334.040.440.4Dengue and dengue hemorrhagic fever. D J GublerClin. Microbiol. Rev.19989665979No
119213341334.050.5550.5Hazards of heavy metal contamination. Lars JärupBr. Med. Bull.200314757716No
119313341334.034.4534.5Recognition of microorganisms and activation of the immune response. Ruslan MedzhitovNature200717943118No
119426661333.094.6447.3Inositol phosphates and cell signalling. M J Berridge, R F IrvineNature19892550825No
119513331333.044.0244.0Cell biology and molecular basis of denitrification. W G ZumftMicrobiol. Mol. Biol. Rev.19979409151No
119613331333.046.7446.7Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. E M WassermannElectroencephalogr Clin Neurophysiol19989474057No
119713321332.00.00.0Evolutionary rate at the molecular level. M KimuraNature19685637732Yes
119813321332.029.5529.6Cancer and the chemokine network. Fran BalkwillNat. Rev. Cancer200415229479No
119913321332.054.4454.4Guided Search 2.0 A revised model of visual search. J M WolfePsychon Bull Rev199424203471Yes
120026631331.556.0528.0SIFT: Predicting amino acid changes that affect protein function. Pauline C Ng, Steven HenikoffNucleic Acids Res.200312824425Yes
120126621331.064.6132.3Insulin signalling and the regulation of glucose and lipid metabolism. A R Saltiel, C R KahnNature200111742412Yes
120213311331.034.3334.3AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. D Grahame HardieNat. Rev. Mol. Cell Biol.200717712357No
120326611330.575.8137.9The Fas death factor. S Nagata, P GolsteinScience19957533326No
120413301330.038.038.0Angiogenesis: an organizing principle for drug discovery? Judah FolkmanNat Rev Drug Discov200717396134No
120513291329.043.643.6The nuclear factor NF-kappaB pathway in inflammation. Toby LawrenceCold Spring Harb Perspect Biol200920457564No
120613291329.064.5664.6Carboxylate-assisted transition-metal-catalyzed C-H bond functionalizations: mechanism and scope. Lutz AckermannChem. Rev.201121391562Yes
120726531326.572.3136.2Liver fibrosis. Ramón Bataller, David A BrennerJ. Clin. Invest.200515690074No
120813261326.033.3333.3The caveolae membrane system. R G AndersonAnnu. Rev. Biochem.19989759488No
120913241324.029.1129.1Hox genes in vertebrate development. R KrumlaufCell19947913880No
121013241324.049.4749.5Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Peter C AustinStat Med200919757444Yes
121126471323.50.00.0Maturation of the head of bacteriophage T4. I. DNA packaging events. U K Laemmli, M FavreJ. Mol. Biol.19734204102Yes
121213221322.00.00.0High-speed scanning in human memory. S SternbergScience19665939936Yes
121313221322.056.8656.9Glutamate: a neurotransmitter in mammalian brain. F FonnumJ. Neurochem.19846139418No
121413211321.083.2583.2Brain dopamine receptors. P SeemanPharmacol. Rev.19806117090No
121539591319.7126.242.1Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Z N Oltvai, C L Milliman, S J KorsmeyerCell19938358790Yes
121626371318.558.6629.3Automated MAD and MIR structure solution. T C Terwilliger, J BerendzenActa Crystallogr. D Biol. Crystallogr.199910089316Yes
121726371318.566.3133.2The epigenomics of cancer. Peter A Jones, Stephen B BaylinCell200717320506No
121813181318.026.3226.3Cyclin-dependent kinases: engines, clocks, and microprocessors. D O MorganAnnu. Rev. Cell Dev. Biol.19979442875No
121913161316.037.8537.9Effects of cytochalasin and phalloidin on actin. J A CooperJ. Cell Biol.19873312229No
122013161316.031.1731.2Role of angiogenesis in tumor growth and metastasis. Judah FolkmanSemin. Oncol.200212516034No
122113151315.029.6429.6Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Judith CampisiCell200515734683No
122213141314.054.8354.8Calculation of substrate oxidation rates in vivo from gaseous exchange. K N FraynJ Appl Physiol Respir Environ Exerc Physiol19836618956Yes
1223144481313.5329.8930.0Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Aravind Subramanian, Pablo Tamayo, Vamsi K Mootha, Sayan Mukherjee, Benjamin L Ebert, Michael A Gillette, Amanda Paulovich, Scott L Pomeroy, Todd R Golub, Eric S Lander, Jill P MesirovProc. Natl. Acad. Sci. U.S.A.200516199517Yes
122413131313.00.00.0Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. D M NevilleJ. Biol. Chem.19715127429Yes
122552491312.20.00.0Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. D J Sahn, A DeMaria, J Kisslo, A WeymanCirculation1978709763Yes
122613121312.032.5532.5An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. R M EsnoufJ. Mol. Graph. Model.19979385560Yes
122713111311.072.5372.5Interleukin-1. C A DinarelloRev. Infect. Dis.19846369481No
122826221311.00.00.0Plaque formation and isolation of pure lines with poliomyelitis viruses. R DULBECCO, M VOGTJ. Exp. Med.195413130792Yes
122926221311.076.7538.4Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Christian Haass, Dennis J SelkoeNat. Rev. Mol. Cell Biol.200717245412No
123039321310.7119.9240.0Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. Earl S Ford, Wayne H Giles, William H DietzJAMA200211790215Yes
123126211310.567.7133.9Parkinson's disease: mechanisms and models. William Dauer, Serge PrzedborskiNeuron200312971891No
123213101310.048.5248.5Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. G C WalkerMicrobiol. Rev.19846371470No
123391641309.1275.3239.3Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. William C Knowler, Elizabeth Barrett-Connor, Sarah E Fowler, Richard F Hamman, John M Lachin, Elizabeth A Walker, David M NathanN. Engl. J. Med.200211832527Yes
123413091309.034.9735.0Fabrication of novel biomaterials through molecular self-assembly. Shuguang ZhangNat. Biotechnol.200314520402No
123526171308.588.8644.4Biofilms: survival mechanisms of clinically relevant microorganisms. Rodney M Donlan, J William CostertonClin. Microbiol. Rev.200211932229No
123613081308.076.3276.3Determinants of low birth weight: methodological assessment and meta-analysis. M S KramerBull. World Health Organ.19873322602No
123713071307.046.9446.9Classification of inflammatory bowel disease. J E Lennard-JonesScand. J. Gastroenterol. Suppl.19892617184Yes
1238130681306.8526.2852.6The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. F C Arnett, S M Edworthy, D A Bloch, D J McShane, J F Fries, N S Cooper, L A Healey, S R Kaplan, M H Liang, H S LuthraArthritis Rheum.19883358796Yes
123913051305.053.5753.6An overview of brominated flame retardants in the environment. Cynthia A de WitChemosphere200211999784No
124013051305.043.5243.5The comet assay for DNA damage and repair: principles, applications, and limitations. Andrew R CollinsMol. Biotechnol.200415004294No
124113041304.00.00.0Comparison of the predicted and observed secondary structure of T4 phage lysozyme. B W MatthewsBiochim. Biophys. Acta19751180967Yes
124213041304.045.5845.6The complete general secretory pathway in gram-negative bacteria. A P PugsleyMicrobiol. Rev.19938096622No
124313041304.00.00.0Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. D AMINOFFBiochem. J.196113860975Yes
124413041304.047.8147.8Social determinants of health inequalities. Michael MarmotLancet200515781105Yes
124513031303.034.2634.3DNA topoisomerases. J C WangAnnu. Rev. Biochem.19968811192No
124613011301.027.4327.4Switching and signaling at the telomere. E H BlackburnCell200111572773No
124726001300.080.3440.2Protein folding in the cell. M J Gething, J SambrookNature19921731198No
124813001300.024.4924.5Cell cycle checkpoint signaling through the ATM and ATR kinases. R T AbrahamGenes Dev.200111544175No
124952001300.0115.0828.8A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. B M Bolstad, R A Irizarry, M Astrand, T P SpeedBioinformatics200312538238Yes
125013001300.00.00.0POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES. D E GoldmanJ. Gen. Physiol.194319873371Yes
125112991299.030.2330.2Mechanisms of cancer drug resistance. Michael M GottesmanAnnu. Rev. Med.200211818492No
125225971298.585.6942.8Dali server: conservation mapping in 3D. Liisa Holm, Päivi RosenströmNucleic Acids Res.201020457744Yes
125312971297.00.00.0Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. J N DumontJ. Morphol.19724109871Yes
125438911297.0107.0635.7Inflammation and atherosclerosis. Peter Libby, Paul M Ridker, Attilio MaseriCirculation200211877368No
125538881296.0212.0670.7The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. C A McHorney, J E Ware, A E RaczekMed Care19938450681Yes
125612961296.044.1344.1Perceptual symbol systems. L W BarsalouBehav Brain Sci199911301525No
125712961296.051.6751.7Grounded cognition. Lawrence W BarsalouAnnu Rev Psychol200817705682No
125838791293.092.3530.8Efficient selection for high-expression transfectants with a novel eukaryotic vector. H Niwa, K Yamamura, J MiyazakiGene19911660837Yes
125912931293.053.7553.8Intracellular calcium homeostasis. E CarafoliAnnu. Rev. Biochem.19873304139No
126012921292.046.146.1New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. R Y TsienBiochemistry19806770893Yes
126112911291.00.00.0Stereological principles for morphometry in electron microscopic cytology. E R WeibelInt. Rev. Cytol.19694899604No
126277461291.0172.8428.8Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. A Fire, S Xu, M K Montgomery, S A Kostas, S E Driver, C C MelloNature19989486653Yes
126312911291.050.4350.4The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. B L FredricksonAm Psychol200111315248Yes
126412911291.036.6936.7Tumor angiogenesis. Robert S KerbelN. Engl. J. Med.200818463380No
126512901290.030.3230.3Points of control in inflammation. Carl NathanNature200212490957No
126612891289.034.5134.5Structural features in eukaryotic mRNAs that modulate the initiation of translation. M KozakJ. Biol. Chem.19911939050No
126725781289.0110.3555.2Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. R A DeFronzo, E FerranniniDiabetes Care19912044434No
126825781289.081.540.8Ab initio molecular-dynamics simulation of the liquid-metal-amorphous-semiconductor transition in germanium. Kresse, HafnerPhys. Rev., B Condens. Matter199410010505Yes
126938641288.0105.2835.1Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Hartmuth C. Kolb, M. G. Finn, K. Barry SharplessAngew. Chem. Int. Ed. Engl.200111433435Yes
127038581286.0113.5637.9Median-joining networks for inferring intraspecific phylogenies. H J Bandelt, P Forster, A RöhlMol. Biol. Evol.199910331250Yes
127112861286.050.550.5The free-energy principle: a unified brain theory? Karl FristonNat. Rev. Neurosci.201020068583No
127238571285.7111.1337.0Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Prateek Kumar, Steven Henikoff, Pauline C NgNat Protoc200919561590Yes
127325711285.5100.3250.2Long-range corrected hybrid density functionals with damped atom-atom dispersion corrections. Jeng-Da Chai, Martin Head-GordonPhys Chem Chem Phys200818989472Yes
127412851285.028.1528.1Cell cycle checkpoints: preventing an identity crisis. S J ElledgeScience19968939848No
127525701285.00.00.0Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. J MARMUR, P DOTYJ. Mol. Biol.196214470099Yes
127625701285.099.7949.9Wnt/β-catenin signaling and disease. Hans Clevers, Roel NusseCell201222682243No
127738531284.389.3329.8A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. Zhang, Chung, OldenburgJ Biomol Screen199910838414Yes
127851291282.2229.8657.5SignalP 4.0: discriminating signal peptides from transmembrane regions. Thomas Nordahl Petersen, Søren Brunak, Gunnar von Heijne, Henrik NielsenNat. Methods201121959131Yes
127912821282.00.00.0A modified card sorting test sensitive to frontal lobe defects. H E NelsonCortex19761009768Yes
128012821282.037.737.7Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. M J MeaneyAnnu. Rev. Neurosci.200111520931No
128125641282.0126.0863.0Extracellular vesicles: exosomes, microvesicles, and friends. Graça Raposo, Willem StoorvogelJ. Cell Biol.201323420871No
128212801280.057.6557.6A cortical network for directed attention and unilateral neglect. M M MesulamAnn. Neurol.19817032417No
128312801280.035.1535.1Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods. Z YangJ. Mol. Evol.19947932792Yes
128412801280.032.0432.0PLANT COLD ACCLIMATION: Freezing Tolerance Genes and Regulatory Mechanisms. Michael F. ThomashowAnnu. Rev. Plant Physiol. Plant Mol. Biol.199915012220Yes
128525591279.569.834.9Neuronal oscillations in cortical networks. György Buzsáki, Andreas DraguhnScience200415218136No
128625581279.053.4226.7Cellular motility driven by assembly and disassembly of actin filaments. Thomas D Pollard, Gary G BorisyCell200312600310No
128712781278.063.2263.2Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. D R JaneroFree Radic. Biol. Med.19902079232No
128812781278.042.9643.0Intestinal mucosal barrier function in health and disease. Jerrold R TurnerNat. Rev. Immunol.200919855405No
128951101277.5238.6159.7Reporting results of cancer treatment. A B Miller, B Hoogstraten, M Staquet, A WinklerCancer19817459811Yes
129012771277.036.2536.2Cellular basis of working memory. P S Goldman-RakicNeuron19957695894No
129112771277.023.1623.2Neuronal specification in the spinal cord: inductive signals and transcriptional codes. T M JessellNat. Rev. Genet.200011262869No
129238291276.377.7125.9Notch signaling: cell fate control and signal integration in development. S Artavanis-Tsakonas, M D Rand, R J LakeScience199910221902No
129312761276.042.542.5Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. H LeVineProtein Sci.19938453378Yes
129412761276.043.3143.3The basal ganglia: focused selection and inhibition of competing motor programs. J W MinkProg. Neurobiol.19969004351No
129512751275.033.8733.9Mammalian G1 cyclins. C J SherrCell19938513492No
129625501275.072.9636.5Origins and Mechanisms of miRNAs and siRNAs. Richard W Carthew, Erik J SontheimerCell200919239886No
129712741274.038.9639.0Adipose tissue, adipokines, and inflammation. Giamila FantuzziJ. Allergy Clin. Immunol.200515867843No
129812721272.037.837.8Precision mapping of quantitative trait loci. Z B ZengGenetics19948013918Yes
1299114461271.8262.6429.2Cytoscape: a software environment for integrated models of biomolecular interaction networks. Paul Shannon, Andrew Markiel, Owen Ozier, Nitin S Baliga, Jonathan T Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, Trey IdekerGenome Res.200314597658Yes
130012711271.053.4953.5Large-scale neurocognitive networks and distributed processing for attention, language, and memory. M M MesulamAnn. Neurol.19902260847No
130125421271.057.9829.0Upstream and downstream of mTOR. Nissim Hay, Nahum SonenbergGenes Dev.200415314020No
130225421271.060.3830.2Signaling to NF-kappaB. Matthew S Hayden, Sankar GhoshGenes Dev.200415371334No
130325411270.568.7134.4Human mesenchymal stem cells modulate allogeneic immune cell responses. Sudeepta Aggarwal, Mark F PittengerBlood200515494428Yes
130412681268.051.0451.0Health consequences of obesity in youth: childhood predictors of adult disease. W H DietzPediatrics199812224658No
130576071267.8295.8149.3Cancer statistics, 2009. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Michael J ThunCA Cancer J Clin200919474385Yes
130612671267.049.5749.6Global epidemiology of oral and oropharyngeal cancer. Saman WarnakulasuriyaOral Oncol.200918804401No
130725331266.556.0728.0Fitting a mixture model by expectation maximization to discover motifs in biopolymers. T L Bailey, C ElkanProc Int Conf Intell Syst Mol Biol19947584402Yes
130812661266.00.00.0The micronucleus test. W SchmidMutat. Res.197548190Yes
130912661266.00.00.0Mode of cell migration to the superficial layers of fetal monkey neocortex. P RakicJ. Comp. Neurol.19724624784Yes
131037981266.083.0227.7T-Coffee: A novel method for fast and accurate multiple sequence alignment. C Notredame, D G Higgins, J HeringaJ. Mol. Biol.200010964570Yes
131112651265.071.0471.0Adverse health effects of high-effort/low-reward conditions. J SiegristJ Occup Health Psychol19969547031No
131212651265.026.8726.9How cells read TGF-beta signals. J MassaguéNat. Rev. Mol. Cell Biol.200011252892No
131312641264.00.00.0Complete nucleotide sequence of the Escherichia coli plasmid pBR322. J G SutcliffeCold Spring Harb. Symp. Quant. Biol.1979383387Yes
131412641264.061.0761.1Intermediate filaments as mechanical integrators of cellular space. E LazaridesNature19807188712Yes
131512641264.044.9945.0Medscape's response to the Institute of Medicine Report: Crossing the quality chasm: a new health system for the 21st century. M LeavittMedGenMed200111549951No
1316126391263.9536.3453.6Measurement of protein using bicinchoninic acid. P K Smith, R I Krohn, G T Hermanson, A K Mallia, F H Gartner, M D Provenzano, E K Fujimoto, N M Goeke, B J Olson, D C KlenkAnal. Biochem.19853843705Yes
131725271263.568.5234.3A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. D Wessel, U I FlüggeAnal. Biochem.19846731838Yes
131812631263.038.4138.4Drug-like properties and the causes of poor solubility and poor permeability. C A LipinskiJ Pharmacol Toxicol Methods200011274893No
131925251262.573.1536.6Empirical threshold values for quantitative trait mapping. G A Churchill, R W DoergeGenetics19947851788Yes
132025241262.00.00.0Receptive fields and functional architecture of monkey striate cortex. D H Hubel, T N WieselJ. Physiol. (Lond.)19684966457Yes
132112611261.042.9843.0Biofilms: microbial life on surfaces. Rodney M DonlanEmerging Infect. Dis.200212194761No
132225221261.063.1731.6Complex networks orchestrate epithelial-mesenchymal transitions. Jean Paul Thiery, Jonathan P SleemanNat. Rev. Mol. Cell Biol.200616493418No
132350441261.0151.2337.8Cancer-related inflammation. Alberto Mantovani, Paola Allavena, Antonio Sica, Frances BalkwillNature200818650914No
1324138651260.5410.1437.3PLINK: a tool set for whole-genome association and population-based linkage analyses. Shaun Purcell, Benjamin Neale, Kathe Todd-Brown, Lori Thomas, Manuel A R Ferreira, David Bender, Julian Maller, Pamela Sklar, Paul I W de Bakker, Mark J Daly, Pak C ShamAm. J. Hum. Genet.200717701901Yes
132525201260.0107.6353.8ITS primers with enhanced specificity for basidiomycetes--application to the identification of mycorrhizae and rusts. M Gardes, T D BrunsMol. Ecol.19938180733Yes
132612601260.033.8733.9Pathogenesis of group A streptococcal infections. M W CunninghamClin. Microbiol. Rev.200010885988No
132712591259.00.00.0In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. T R ChenExp. Cell Res.197765285Yes
132812591259.034.8734.9A revolution in optical manipulation. David G GrierNature200312917694No
132925181259.070.9135.5The BCL-2 protein family: opposing activities that mediate cell death. Richard J Youle, Andreas StrasserNat. Rev. Mol. Cell Biol.200818097445No
133012581258.032.8132.8An analysis of vertebrate mRNA sequences: intimations of translational control. M KozakJ. Cell Biol.19911955461No
133112581258.091.691.6Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Daniël LakensFront Psychol201324324449No
133212571257.036.4836.5Structural design and molecular evolution of a cytokine receptor superfamily. J F BazanProc. Natl. Acad. Sci. U.S.A.19902169613Yes
133325141257.054.0727.0Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. O Tetsu, F McCormickNature199910201372Yes
133412571257.034.534.5Hypertrophic cardiomyopathy: a systematic review. Barry J MaronJAMA200211886323No
133512561256.053.5953.6Pineal melatonin: cell biology of its synthesis and of its physiological interactions. R J ReiterEndocr. Rev.19911649044No
1336100381254.8396.5749.6Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. R K Saiki, D H Gelfand, S Stoffel, S J Scharf, R Higuchi, G T Horn, K B Mullis, H A ErlichScience19882448875Yes
133725091254.5133.2366.6A standardized set of 260 pictures: norms for name agreement, image agreement, familiarity, and visual complexity. J G Snodgrass, M VanderwartJ Exp Psychol Hum Learn19807373248Yes
133825091254.562.431.2Cell migration: a physically integrated molecular process. D A Lauffenburger, A F HorwitzCell19968608589No
133912541254.00.00.0A rating instrument for anxiety disorders. W W ZungPsychosomatics19715172928Yes
134012531253.058.0758.1Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? B HalliwellLancet19947915779No
134112531253.033.1833.2Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. M B LuskinNeuron19938338665Yes
134212531253.032.7432.7Trastuzumab--mechanism of action and use in clinical practice. Clifford A HudisN. Engl. J. Med.200717611206No
134375161252.7258.5743.1Positional cloning of the mouse obese gene and its human homologue. Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M FriedmanNature19947984236Yes
134412521252.00.00.0Areas, volumes, packing and protein structure. F M RichardsAnnu. Rev. Biophys. Bioeng.1977326146No
134512521252.031.6231.6Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. G L SemenzaAnnu. Rev. Cell Dev. Biol.199910611972No
134612521252.035.7135.7Episodic memory: from mind to brain. Endel TulvingAnnu Rev Psychol200211752477Yes
134712521252.034.3634.4The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Michael R LieberAnnu. Rev. Biochem.201020192759No
134812521252.049.8149.8Hypoxia-inducible factors in physiology and medicine. Gregg L SemenzaCell201222304911No
134912511251.026.9727.0Neuroblastoma: biological insights into a clinical enigma. Garrett M BrodeurNat. Rev. Cancer200312612655No
135012511251.054.3954.4Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Sergio PecorelliInt J Gynaecol Obstet200919367689No
135125011250.50.00.0A fluorometric method for determination of oxidized and reduced glutathione in tissues. P J Hissin, R HilfAnal. Biochem.1976962076Yes
135212491249.025.9125.9Vienna RNA secondary structure server. Ivo L HofackerNucleic Acids Res.200312824340Yes
135312491249.034.8334.8Growth of the plant cell wall. Daniel J CosgroveNat. Rev. Mol. Cell Biol.200516261190No
135424971248.5123.5161.8The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. A J Stunkard, S MessickJ Psychosom Res19853981480Yes
135512481248.035.2435.2A cell culture model for T lymphocyte clonal anergy. R H SchwartzScience19902113314Yes
135612481248.035.6635.7An economic method for the fluorescent labeling of PCR fragments. M SchuelkeNat. Biotechnol.200010657137Yes
135712481248.00.00.0The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations. W W CLELANDBiochim. Biophys. Acta196314021667Yes
135824961248.099.6749.8Understanding interobserver agreement: the kappa statistic. Anthony J Viera, Joanne M GarrettFam Med200515883903Yes
135924961248.081.7940.9The inflammasomes. Kate Schroder, Jurg TschoppCell201020303873No
136012471247.038.8238.8Binary Agrobacterium vectors for plant transformation. M BevanNucleic Acids Res.19846095209Yes
136137411247.0121.3140.4The metabolic syndrome--a new worldwide definition. K George M M Alberti, Paul Zimmet, Jonathan ShawLancet200516182882Yes
136212461246.059.0859.1The linear-quadratic formula and progress in fractionated radiotherapy. J F FowlerBr J Radiol19892670032No
136312461246.045.9746.0Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Y Ben-AriNeuroscience19852859548No
136424911245.560.3730.2Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. E Krissinel, K HenrickActa Crystallogr. D Biol. Crystallogr.200415572779Yes
136537351245.0153.9351.3Phylogenetic identification and in situ detection of individual microbial cells without cultivation. R I Amann, W Ludwig, K H SchleiferMicrobiol. Rev.19957535888No
136612451245.041.0941.1What we can do and what we cannot do with fMRI. Nikos K LogothetisNature200818548064No
1367124461244.6343.8134.4Multilineage potential of adult human mesenchymal stem cells. M F Pittenger, A M Mackay, S C Beck, R K Jaiswal, R Douglas, J D Mosca, M A Moorman, D W Simonetti, S Craig, D R MarshakScience199910102814Yes
136824891244.559.8429.9The Ki-67 protein: from the known and the unknown. T Scholzen, J GerdesJ. Cell. Physiol.200010653597No
136912441244.052.5752.6Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. D W ChoiTrends Neurosci.19882469166No
137024881244.088.9344.5Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. P J Basser, C PierpaoliJ Magn Reson B19968661285Yes
137112441244.044.544.5Flavonoids as antioxidants. P G PiettaJ. Nat. Prod.200010924197No
137212441244.044.6644.7The in vitro micronucleus technique. M FenechMutat. Res.200011113469No
137337321244.091.6730.6An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J K Eng, A L McCormack, J R YatesJ. Am. Soc. Mass Spectrom.199424226387Yes
137412431243.050.6950.7Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. M ZasloffProc. Natl. Acad. Sci. U.S.A.19873299384Yes
137512431243.044.8144.8Introduction and General Overview of Cyclodextrin Chemistry. József SzejtliChem. Rev.199811848947Yes
137612431243.00.00.0A METHOD OF MEASURING EYE MOVEMENT USING A SCLERAL SEARCH COIL IN A MAGNETIC FIELD. D A ROBINSONIEEE Trans Biomed Eng196314121113Yes
137712421242.059.4959.5Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. P HolzerPharmacol. Rev.19911852779No
137812421242.034.2334.2Thiazolidinediones. Hannele Yki-JärvinenN. Engl. J. Med.200415356308No
137912411241.034.3934.4NADPH oxidase: an update. B M BabiorBlood199910029572No
138012411241.040.5640.6Oxidative stress and neurodegeneration: where are we now? Barry HalliwellJ. Neurochem.200616805774No
138124801240.083.4141.7Rapid and sensitive protein similarity searches. D J Lipman, W R PearsonScience19852983426Yes
138212401240.031.6131.6From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. W A CatterallNeuron200010798388No
138324791239.557.1228.6Toll-like receptor control of the adaptive immune responses. Akiko Iwasaki, Ruslan MedzhitovNat. Immunol.200415454922No
138412391239.026.0626.1Germinal centers. I C MacLennanAnnu. Rev. Immunol.19948011279No
138537151238.394.5131.5Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. J E Darnell, I M Kerr, G R StarkScience19948197455No
138612381238.00.00.0The Gingival Index, the Plaque Index and the Retention Index Systems. H LöeJ. Periodontol.19675237684Yes
138749511237.8141.5935.4Improved optimization for the robust and accurate linear registration and motion correction of brain images. Mark Jenkinson, Peter Bannister, Michael Brady, Stephen SmithNeuroimage200212377157Yes
138812371237.036.4836.5Recognition of errors in three-dimensional structures of proteins. M J SipplProteins19938108378Yes
138912361236.00.00.0Statistical analysis of enzyme kinetic data. W W ClelandMeth. Enzymol.1979502857Yes
139012361236.033.8433.8Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. B L WajchenbergEndocr. Rev.200011133069No
139112361236.026.4926.5Protein degradation and protection against misfolded or damaged proteins. Alfred L GoldbergNature200314685250No
139261781235.6148.8829.8Stages of embryonic development of the zebrafish. C B Kimmel, W W Ballard, S R Kimmel, B Ullmann, T F SchillingDev. Dyn.19958589427Yes
139312351235.00.00.0The relationship between the spleen colony-forming cell and the haemopoietic stem cell. R SchofieldBlood Cells1978747780Yes
139412351235.039.8939.9Leptospirosis. P N LevettClin. Microbiol. Rev.200111292640No
139512341234.00.00.0Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. B E MurphyJ. Clin. Endocrinol. Metab.19674291524Yes
139624651232.5100.0850.0Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. F Denizot, R LangJ. Immunol. Methods19863486233Yes
139736961232.0147.9949.3Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. H Esterbauer, R J Schaur, H ZollnerFree Radic. Biol. Med.19911937131No
139812321232.038.6838.7Solvent-accessible surfaces of proteins and nucleic acids. M L ConnollyScience19836879170Yes
139912321232.048.4348.4Constructions of masculinity and their influence on men's well-being: a theory of gender and health. W H CourtenaySoc Sci Med200010741575No
140024641232.058.2629.1Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Gary L Johnson, Razvan LapadatScience200212471242No
140124641232.070.2235.1Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Robert Visse, Hideaki NagaseCirc. Res.200312730128No
140212321232.024.6224.6Automated electron microscope tomography using robust prediction of specimen movements. David N MastronardeJ. Struct. Biol.200516182563Yes
140312311231.065.3965.4Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. P HolzerNeuroscience19883288903No
140412311231.00.00.0R factor transfer in Rhizobium leguminosarum. J E BeringerJ. Gen. Microbiol.19744612098Yes
140512311231.042.242.2MYC on the path to cancer. Chi V DangCell201222464321No
140612301230.035.6135.6HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. J M CoffinScience19957824947Yes
140712301230.00.00.0Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. S COHENJ. Biol. Chem.196213880319Yes
140824561228.00.00.0Prediction of the secondary structure of proteins from their amino acid sequence. P Y Chou, G D FasmanAdv. Enzymol. Relat. Areas Mol. Biol.1978364941No
140912281228.051.951.9Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). M N MarshGastroenterology19921727768No
141012281228.037.5337.5From sensation to cognition. M M MesulamBrain19989648540No
141149101227.5152.8538.2p53 mutations in human cancers. M Hollstein, D Sidransky, B Vogelstein, C C HarrisScience19911905840No
141224541227.0108.8554.4Palladium-catalyzed ligand-directed C-H functionalization reactions. Thomas W Lyons, Melanie S SanfordChem. Rev.201020078038No
141324531226.580.440.2Diarrheagenic Escherichia coli. J P Nataro, J B KaperClin. Microbiol. Rev.19989457432No
141412251225.063.463.4Perception of risk. P SlovicScience19873563507Yes
141524501225.0113.0156.5Pain assessment: global use of the Brief Pain Inventory. C S Cleeland, K M RyanAnn Acad Med Singap19948080219No
141624491224.555.7427.9NF-kappaB regulation in the immune system. Qiutang Li, Inder M VermaNat. Rev. Immunol.200212360211No
141724491224.582.9741.5The unfolded protein response: from stress pathway to homeostatic regulation. Peter Walter, David RonScience201122116877No
141812241224.060.7460.7Probiotics in man and animals. R FullerJ. Appl. Bacteriol.19892666378No
141912231223.035.2435.2The biology of incretin hormones. Daniel J DruckerCell Metab.200616517403No
142012221222.00.00.0Selforganization of matter and the evolution of biological macromolecules. M EigenNaturwissenschaften19714942363No
142124421221.00.00.0Multiple receptors for dopamine. J W Kebabian, D B CalneNature1979215920No
142261051221.0184.0236.8Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. Alan S Go, Glenn M Chertow, Dongjie Fan, Charles E McCulloch, Chi-yuan HsuN. Engl. J. Med.200415385656Yes
142312201220.039.6139.6Oxidative stress hypothesis in Alzheimer's disease. W R MarkesberyFree Radic. Biol. Med.19979165306No
142412201220.037.1737.2An index to quantify an individual's scientific research output. J E HirschProc. Natl. Acad. Sci. U.S.A.200516275915Yes
142536591219.7111.137.0Canonical sampling through velocity rescaling. Giovanni Bussi, Davide Donadio, Michele ParrinelloJ Chem Phys200717212484Yes
142624391219.5196.2298.1A clinical method of functional assessment of the shoulder. C R Constant, A H MurleyClin. Orthop. Relat. Res.19873791738Yes
142724381219.00.00.0The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites. J Shine, L DalgarnoProc. Natl. Acad. Sci. U.S.A.19744598299Yes
142812191219.034.2534.2The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. D M KingsleyGenes Dev.19948299934No
142912181218.036.8536.9The corticosteroid receptor hypothesis of depression. F HolsboerNeuropsychopharmacology200011027914No
143012181218.00.00.0Cerebral vascular accidents in patients over the age of 60. II. Prognosis. J RANKINScott Med J195713432835Yes
143148711217.8148.0137.0Use of T7 RNA polymerase to direct expression of cloned genes. F W Studier, A H Rosenberg, J J Dunn, J W DubendorffMeth. Enzymol.19902199796Yes
143212171217.030.0330.0An approximately unbiased test of phylogenetic tree selection. Hidetoshi ShimodairaSyst. Biol.200212079646Yes
143312171217.028.5728.6Neurotrophins and their receptors: a convergence point for many signalling pathways. Moses V ChaoNat. Rev. Neurosci.200312671646No
143424341217.066.7333.4PRODRG: a tool for high-throughput crystallography of protein-ligand complexes. Alexander W Schüttelkopf, Daan M F van AaltenActa Crystallogr. D Biol. Crystallogr.200415272157Yes
143536501216.7117.5239.2The fusiform face area: a module in human extrastriate cortex specialized for face perception. N Kanwisher, J McDermott, M M ChunJ. Neurosci.19979151747Yes
143624321216.00.00.0Polymyositis and dermatomyositis (first of two parts). A Bohan, J B PeterN. Engl. J. Med.19751090839No
143712161216.046.8346.8The role of the amygdala in fear and anxiety. M DavisAnnu. Rev. Neurosci.19921575447No
143812161216.033.6433.6On finding all suboptimal foldings of an RNA molecule. M ZukerScience19892468181No
143912161216.068.0168.0The drug abuse screening test. H A SkinnerAddict Behav19827183189Yes
144012151215.043.843.8Multiple imputation: a primer. J L SchaferStat Methods Med Res199910347857No
144112151215.00.00.0ENZYMATIC BASIS FOR ACTIVE TRANSPORT OF NA+ AND K+ ACROSS CELL MEMBRANE. J C SKOUPhysiol. Rev.196514337569No
144212151215.042.9242.9Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Ralph A DefronzoDiabetes200919336687No
144336441214.7108.3736.1A neural substrate of prediction and reward. W Schultz, P Dayan, P R MontagueScience19979054347No
144448581214.5236.7559.216S ribosomal DNA amplification for phylogenetic study. W G Weisburg, S M Barns, D A Pelletier, D J LaneJ. Bacteriol.19911987160Yes
144512141214.030.5330.5Perceptions of epigenetics. Adrian BirdNature200717522671Yes
144612131213.00.00.0A simple fluorometric assay for lipoperoxide in blood plasma. K YagiBiochem Med1976962904Yes
144724261213.095.447.7Separate visual pathways for perception and action. M A Goodale, A D MilnerTrends Neurosci.19921374953No
144824261213.080.8640.4Event-related EEG/MEG synchronization and desynchronization: basic principles. G Pfurtscheller, F H Lopes da SilvaClin Neurophysiol199910576479No
144996971212.1284.5535.6Electric field effect in atomically thin carbon films. K S Novoselov, A K Geim, S V Morozov, D Jiang, Y Zhang, S V Dubonos, I V Grigorieva, A A FirsovScience200415499015Yes
145024241212.060.9530.5Fibroblasts in cancer. Raghu Kalluri, Michael ZeisbergNat. Rev. Cancer200616572188No
145124231211.550.4825.2The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Michael H Glickman, Aaron CiechanoverPhysiol. Rev.200211917093No
145212111211.035.8335.8Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Shitij KapurAm J Psychiatry200312505794No
145312111211.041.4641.5Porous scaffold design for tissue engineering. Scott J HollisterNat Mater200516003400No
145412101210.040.2540.2Molecular dissection of reactive astrogliosis and glial scar formation. Michael V SofroniewTrends Neurosci.200919782411No
145524181209.0143.7771.9phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. Paul J McMurdie, Susan HolmesPLoS ONE201323630581Yes
145612081208.026.4126.4Intrinsically unstructured proteins. Peter TompaTrends Biochem. Sci.200212368089No
145724151207.589.3944.7Oxidative stress, glutamate, and neurodegenerative disorders. J T Coyle, P PuttfarckenScience19937901908No
145836221207.31395.48465.2Cancer statistics, 2019. Rebecca L Siegel, Kimberly D Miller, Ahmedin JemalCA Cancer J Clin201930620402Yes
145912071207.00.00.0Separation of leukocytes from blood and bone marrow. Introduction. A BöyumScand. J. Clin. Lab. Invest. Suppl.19685707208Yes
146024141207.0116.5458.3The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. P F Lovibond, S H LovibondBehav Res Ther19957726811Yes
146124141207.053.626.8Missing pieces in the NF-kappaB puzzle. Sankar Ghosh, Michael KarinCell200211983155No
146224141207.058.5329.3Why do cancers have high aerobic glycolysis? Robert A Gatenby, Robert J GilliesNat. Rev. Cancer200415516961No
146312071207.033.0933.1The retinal pigment epithelium in visual function. Olaf StraussPhysiol. Rev.200515987797No
146436191206.3158.0752.7A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. J R Le Gall, S Lemeshow, F SaulnierJAMA19938254858Yes
146524121206.072.5536.3Quantum dot bioconjugates for ultrasensitive nonisotopic detection. W C Chan, S NieScience19989748158Yes
146612061206.028.3728.4Oxidative stress shortens telomeres. Thomas von ZglinickiTrends Biochem. Sci.200212114022Yes
146712061206.00.00.0Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. E G GRAYJ. Anat.195913829103Yes
146812061206.026.4726.5RNA silencing in plants. David BaulcombeNature200415372043No
146912061206.034.6834.7Tricine-SDS-PAGE. Hermann SchäggerNat Protoc200617406207Yes
147048231205.8135.533.9Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. C A Lipinski, F Lombardo, B W Dominy, P J FeeneyAdv. Drug Deliv. Rev.200111259830No
147172351205.8262.6543.8Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Patricia Berglund, Olga Demler, Robert Jin, Kathleen R Merikangas, Ellen E WaltersArch. Gen. Psychiatry200515939837Yes
147212051205.00.00.0Why genes in pieces? W GilbertNature1978622185Yes
147336151205.0119.9440.0Dating of the human-ape splitting by a molecular clock of mitochondrial DNA. M Hasegawa, H Kishino, T YanoJ. Mol. Evol.19853934395Yes
147412051205.00.00.0Influences of glucose loading and of injected insulin on hepatic glucose output. R STEELEAnn. N. Y. Acad. Sci.195913833973Yes
147512041204.029.4129.4How eukaryotic transcriptional activators work. M PtashneNature19883050531No
147624061203.076.1938.1Building better batteries. M Armand, J-M TarasconNature200818256660No
147712021202.075.7775.8Measurement of health state utilities for economic appraisal. G W TorranceJ Health Econ198610311607No
147812011201.00.00.0The genetical evolution of social behaviour. II. W D HamiltonJ. Theor. Biol.19645875340Yes
147912011201.023.3923.4Histone acetylation and transcriptional regulatory mechanisms. K StruhlGenes Dev.19989499396No
148024021201.00.00.0A "DIRECT-COLORING" THIOCHOLINE METHOD FOR CHOLINESTERASES. M J KARNOVSKY, L ROOTSJ. Histochem. Cytochem.196414187330Yes
148112001200.031.4131.4Far-field optical nanoscopy. Stefan W HellScience200717525330No
148235991199.70.00.0Impact of Event Scale: a measure of subjective stress. M Horowitz, N Wilner, W AlvarezPsychosom Med1979472086Yes
148311991199.00.00.0Impulses and Physiological States in Theoretical Models of Nerve Membrane. R FitzhughBiophys. J.196119431309Yes
148411991199.031.3431.3The hippo signaling pathway in development and cancer. Duojia PanDev. Cell201020951342No
148523971198.551.125.6The evolutionary fate and consequences of duplicate genes. M Lynch, J S ConeryScience200011073452No
148623971198.564.8632.4Shared principles in NF-kappaB signaling. Matthew S Hayden, Sankar GhoshCell200818267068No
148711981198.027.5427.5Regulatory T cells, tumour immunity and immunotherapy. Weiping ZouNat. Rev. Immunol.200616557261No
148811981198.00.00.0THE ESTIMATION OF PEPSIN, TRYPSIN, PAPAIN, AND CATHEPSIN WITH HEMOGLOBIN. M L AnsonJ. Gen. Physiol.193819873094Yes
148911971197.00.00.0Chromatin structure: a repeating unit of histones and DNA. R D KornbergScience19744825889Yes
149011971197.051.051.0Number of people with glaucoma worldwide. H A QuigleyBr J Ophthalmol19968695555No
149111961196.00.00.0TRANSFORMATION OF BIOCHEMICALLY DEFICIENT STRAINS OF BACILLUS SUBTILIS BY DEOXYRIBONUCLEATE. J SpizizenProc. Natl. Acad. Sci. U.S.A.195816590310Yes
149247811195.2156.4239.1Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. B Biswal, F Z Yetkin, V M Haughton, J S HydeMagn Reson Med19958524021Yes
149311951195.034.0834.1Insulin and insulin-like growth factor signalling in neoplasia. Michael PollakNat. Rev. Cancer200819029956No
149423891194.593.0546.5Unified approach for molecular dynamics and density-functional theory. Car, ParrinelloPhys. Rev. Lett.198510032153Yes
149511941194.00.00.0Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. K O FagerströmAddict Behav1978735910Yes
149611941194.046.7146.7The biology of interleukin-6. T KishimotoBlood19892473791No
149723881194.057.2728.6Coordination of circadian timing in mammals. Steven M Reppert, David R WeaverNature200212198538No
149823881194.065.6232.8The human plasma proteome: history, character, and diagnostic prospects. N Leigh Anderson, Norman G AndersonMol. Cell Proteomics200212488461No
149911931193.028.7528.8Neurotrophins as synaptic modulators. M M PooNat. Rev. Neurosci.200111253356No
150011921192.050.8450.8Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. H J GundersenJ Microsc19863761363Yes
150111911191.029.5229.5A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Dale R NyholtAm. J. Hum. Genet.200414997420Yes
150211911191.040.5340.5Accurate Coulomb-fitting basis sets for H to Rn. Florian WeigendPhys Chem Chem Phys200616633586Yes
150359521190.4133.9726.8Prospective identification of tumorigenic breast cancer cells. Muhammad Al-Hajj, Max S Wicha, Adalberto Benito-Hernandez, Sean J Morrison, Michael F ClarkeProc. Natl. Acad. Sci. U.S.A.200312629218Yes
150411901190.024.3724.4Aggresomes, inclusion bodies and protein aggregation. R R KopitoTrends Cell Biol.200011121744No
150511891189.038.3238.3The world health report 2002 - reducing risks, promoting healthy life. J J GuilbertEduc Health (Abingdon)200314741909Yes
150611891189.027.3627.4The Buccaneer software for automated model building. 1. Tracing protein chains. Kevin CowtanActa Crystallogr. D Biol. Crystallogr.200616929101Yes
150747551188.80.00.0Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. E A Jaffe, R L Nachman, C G Becker, C R MinickJ. Clin. Invest.19734355998Yes
150811881188.00.00.0Which elements are excited in electrical stimulation of mammalian central nervous system: a review. J B RanckBrain Res.19751102064No
150935641188.0132.0644.0Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. P A Wolf, R D Abbott, W B KannelStroke19911866765Yes
151023761188.082.1241.1Nonparametric statistical testing of EEG- and MEG-data. Eric Maris, Robert OostenveldJ. Neurosci. Methods200717517438Yes
151123741187.081.4840.7A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. S Tabor, C C RichardsonProc. Natl. Acad. Sci. U.S.A.19853156376Yes
151211871187.026.3926.4Immunosuppressive networks in the tumour environment and their therapeutic relevance. Weiping ZouNat. Rev. Cancer200515776005No
151323731186.5152.5576.3Interrater reliability of a modified Ashworth scale of muscle spasticity. R W Bohannon, M B SmithPhys Ther19873809245Yes
151411861186.039.739.7The pathophysiology of tumor necrosis factors. P VassalliAnnu. Rev. Immunol.19921590993No
151511851185.00.00.0Simple memory: a theory for archicortex. D MarrPhilos. Trans. R. Soc. Lond., B, Biol. Sci.19714399412Yes
151635511183.788.8329.6NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. S Ghosh, M J May, E B KoppAnnu. Rev. Immunol.19989597130No
151723671183.5122.3261.2Avoiding false positives with PCR. S Kwok, R HiguchiNature19892716852Yes
151811831183.050.2950.3The crisis in antibiotic resistance. H C NeuScience19921509257No
151911831183.041.9241.9A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. P J GoodfordJ. Med. Chem.19853892003Yes
152023651182.563.1631.6The DNA-damage response in human biology and disease. Stephen P Jackson, Jiri BartekNature200919847258No
152111821182.042.9142.9Interleukin-6: an overview. J Van SnickAnnu. Rev. Immunol.19902188664No
152211801180.061.8961.9Responses to depression and their effects on the duration of depressive episodes. S Nolen-HoeksemaJ Abnorm Psychol19911757671No
152335381179.3132.8144.3FastTree 2--approximately maximum-likelihood trees for large alignments. Morgan N Price, Paramvir S Dehal, Adam P ArkinPLoS ONE201020224823Yes
152411791179.00.00.0Ionic blockage of sodium channels in nerve. A M WoodhullJ. Gen. Physiol.19734541078Yes
152511791179.065.565.5Cell damage in the brain: a speculative synthesis. B K SiesjöJ. Cereb. Blood Flow Metab.19816276420No
152611791179.045.3945.4Gold-catalyzed organic reactions. A Stephen K HashmiChem. Rev.200717580975Yes
152711781178.00.00.0Amino acid difference formula to help explain protein evolution. R GranthamScience19744843792Yes
152835341178.085.4428.5Toll-like receptors. Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo AkiraAnnu. Rev. Immunol.200312524386No
152911771177.00.00.0Paced auditory serial-addition task: a measure of recovery from concussion. D M GronwallPercept Mot Skills1977866038Yes
153011771177.035.3535.4Stress and hippocampal plasticity. B S McEwenAnnu. Rev. Neurosci.199910202533No
153111771177.032.7532.8The mitochondrial permeability transition pore and its role in cell death. M CromptonBiochem. J.199910393078No
153223541177.098.2849.1Macrophage plasticity and polarization: in vivo veritas. Antonio Sica, Alberto MantovaniJ. Clin. Invest.201222378047No
153323531176.5104.4952.2Role of free radicals and catalytic metal ions in human disease: an overview. B Halliwell, J M GutteridgeMeth. Enzymol.19902172697No
153411761176.00.00.0Fluorescence energy transfer as a spectroscopic ruler. L StryerAnnu. Rev. Biochem.1978354506No
153511761176.033.633.6The proto-oncogene Bcl-2 and its role in regulating apoptosis. G KroemerNat. Med.19979176486No
153623521176.067.2333.6Adipose tissue as an endocrine organ. Erin E Kershaw, Jeffrey S FlierJ. Clin. Endocrinol. Metab.200415181022No
153723511175.555.927.9Chemokines: a new classification system and their role in immunity. A Zlotnik, O YoshieImmunity200010714678No
153811751175.042.0242.0The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. R R LlinásScience19883059497No
153911751175.047.0547.0The stress response in fish. S E Wendelaar BongaPhysiol. Rev.19979234959No
154011751175.035.4835.5Network pharmacology: the next paradigm in drug discovery. Andrew L HopkinsNat. Chem. Biol.200818936753No
154111741174.047.1347.1Extracellular ATP: effects, sources and fate. J L GordonBiochem. J.19863006665No
154211741174.032.8832.9In vivo near-infrared fluorescence imaging. John V FrangioniCurr Opin Chem Biol200314580568No
154335191173.0101.3433.8Two-photon laser scanning fluorescence microscopy. W Denk, J H Strickler, W W WebbScience19902321027Yes
154423461173.062.0831.0A comparison of bayesian methods for haplotype reconstruction from population genotype data. Matthew Stephens, Peter DonnellyAm. J. Hum. Genet.200314574645Yes
154511721172.038.3938.4Alpha-crystallin can function as a molecular chaperone. J HorwitzProc. Natl. Acad. Sci. U.S.A.19921438232Yes
154623441172.059.2729.6Issues and challenges facing rechargeable lithium batteries. J M Tarascon, M ArmandNature200111713543Yes
154711721172.00.00.0The influence of some cations on an adenosine triphosphatase from peripheral nerves. J C SKOUBiochim. Biophys. Acta195713412736Yes
154811721172.032.1632.2Neurovascular regulation in the normal brain and in Alzheimer's disease. Costantino IadecolaNat. Rev. Neurosci.200415100718No
154946881172.0134.1233.5Improved prediction of signal peptides: SignalP 3.0. Jannick Dyrløv Bendtsen, Henrik Nielsen, Gunnar von Heijne, Søren BrunakJ. Mol. Biol.200415223320Yes
155023421171.00.00.0Variations in the pattern of pubertal changes in boys. W A Marshall, J M TannerArch. Dis. Child.19705440182Yes
155111711171.039.4439.4Oxidative stress: oxidants and antioxidants. H SiesExp. Physiol.19979129943No
155211711171.030.4230.4Introduction to NF-kappaB: players, pathways, perspectives. T D GilmoreOncogene200617072321No
155311701170.031.2531.2Five rules for the evolution of cooperation. Martin A NowakScience200617158317No
155411691169.032.0832.1Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. S C ManolagasEndocr. Rev.200010782361No
155511691169.037.1737.2Task switching. Stephen MonsellTrends Cogn. Sci. (Regul. Ed.)200312639695Yes
155635051168.3266.4388.8Deep learning. Yann LeCun, Yoshua Bengio, Geoffrey HintonNature201526017442No
155711681168.048.2748.3Cellular defenses against damage from reactive oxygen species. B P YuPhysiol. Rev.19948295932No
155811681168.027.4427.4Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. R K JainNat. Med.200111533692No
155911671167.043.4743.5Ionic dependence of glutamate neurotoxicity. D W ChoiJ. Neurosci.19872880938Yes
156011671167.032.2932.3A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. D A GewirtzBiochem. Pharmacol.199910075079No
156111671167.024.9825.0Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing. D I SvergunBiophys. J.199910354416Yes
156246641166.0246.5661.6An inventory for measuring clinical anxiety: psychometric properties. A T Beck, N Epstein, G Brown, R A SteerJ Consult Clin Psychol19883204199Yes
156311661166.056.2556.2Simple proton spectroscopic imaging. W T DixonRadiology19846089263Yes
156411651165.00.00.0The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. R RossJ. Cell Biol.19714327464Yes
156511651165.040.6840.7Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. P A BradfordClin. Microbiol. Rev.200111585791No
156634951165.085.5128.5TOR signaling in growth and metabolism. Stephan Wullschleger, Robbie Loewith, Michael N HallCell200616469695No
156711651165.039.3539.4n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Philip C CalderAm. J. Clin. Nutr.200616841861No
156881531164.7192.0627.4Embryonic stem cell lines derived from human blastocysts. J A Thomson, J Itskovitz-Eldor, S S Shapiro, M A Waknitz, J J Swiergiel, V S Marshall, J M JonesScience19989804556Yes
156923291164.5105.4152.7The biofilm matrix. Hans-Curt Flemming, Jost WingenderNat. Rev. Microbiol.201020676145No
157023281164.062.0531.0How matrix metalloproteinases regulate cell behavior. M D Sternlicht, Z WerbAnnu. Rev. Cell Dev. Biol.200111687497No
157134911163.7104.2734.8The rapid generation of mutation data matrices from protein sequences. D T Jones, W R Taylor, J M ThorntonComput. Appl. Biosci.19921633570Yes
157223271163.554.9227.5The Bcl2 family: regulators of the cellular life-or-death switch. Suzanne Cory, Jerry M AdamsNat. Rev. Cancer200212209154No
157311631163.058.7858.8Modeling and variable selection in epidemiologic analysis. S GreenlandAm J Public Health19892916724Yes
157411631163.042.6342.6Glycobiology: Toward Understanding the Function of Sugars. Raymond A. DwekChem. Rev.199611848770Yes
157511631163.034.7834.8Use and misuse of the receiver operating characteristic curve in risk prediction. Nancy R CookCirculation200717309939Yes
157623241162.087.8643.9Prediction of protein antigenic determinants from amino acid sequences. T P Hopp, K R WoodsProc. Natl. Acad. Sci. U.S.A.19816167991Yes
157723241162.088.1944.1A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments. J Messing, J VieiraGene19826295880Yes
157811621162.040.140.1Leishmaniasis: current situation and new perspectives. P DesjeuxComp. Immunol. Microbiol. Infect. Dis.200415225981No
157911611161.033.0933.1Origin, biogenesis, and activity of plant microRNAs. Olivier VoinnetCell200919239888No
158023201160.00.00.0Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. D H Figurski, D R HelinskiProc. Natl. Acad. Sci. U.S.A.1979377280Yes
158111601160.056.4956.5Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. Virginia A MoyerAnn. Intern. Med.201222801674No
158246391159.80.00.0The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. S P Baker, B O'Neill, W Haddon, W B LongJ Trauma19744814394Yes
158311591159.00.00.0Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters. J M VAN ROSSUMArch Int Pharmacodyn Ther196313996119Yes
158423181159.078.6939.3Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. B R Celli, W MacNeeEur. Respir. J.200415219010No
158534741158.00.00.0Research diagnostic criteria: rationale and reliability. R L Spitzer, J Endicott, E RobinsArch. Gen. Psychiatry1978655775Yes
158611581158.036.836.8Molecular biology of prion diseases. S B PrusinerScience19911675487No
158723161158.0107.2853.6The transtheoretical model of health behavior change. J O Prochaska, W F VelicerAm J Health Promot199710170434No
158811581158.031.9732.0Python: a programming language for software integration and development. M F SannerJ. Mol. Graph. Model.199910660911Yes
158911581158.027.9127.9Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. S S FergusonPharmacol. Rev.200111171937No
159023151157.577.4438.7The precuneus: a review of its functional anatomy and behavioural correlates. Andrea E Cavanna, Michael R TrimbleBrain200616399806No
159111571157.00.00.0The inverse care law. J T HartLancet19714100731Yes
159246251156.2115.6928.9Probability-based protein identification by searching sequence databases using mass spectrometry data. D N Perkins, D J Pappin, D M Creasy, J S CottrellElectrophoresis199910612281Yes
159311561156.047.7647.8History of the Rochester Epidemiology Project. L J MeltonMayo Clin. Proc.19968594285No
159411561156.028.5428.5Cancer epigenomics: DNA methylomes and histone-modification maps. Manel EstellerNat. Rev. Genet.200717339880No
1595150261155.8471.5436.3Clustal W and Clustal X version 2.0. M A Larkin, G Blackshields, N P Brown, R Chenna, P A McGettigan, H McWilliam, F Valentin, I M Wallace, A Wilm, R Lopez, J D Thompson, T J Gibson, D G HigginsBioinformatics200717846036Yes
159634661155.394.8731.6Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Daniel Falush, Matthew Stephens, Jonathan K PritchardGenetics200312930761Yes
159711551155.079.3179.3Muscle and tendon: properties, models, scaling, and application to biomechanics and motor control. F E ZajacCrit Rev Biomed Eng19892676342No
159811551155.00.00.0METHOD FOR ASSAY OF INTESTINAL DISACCHARIDASES. A DAHLQVISTAnal. Biochem.196414106916Yes
159923091154.587.2743.6Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. M Karas, F HillenkampAnal. Chem.19883239801Yes
160011541154.031.5731.6PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. B M SpiegelmanDiabetes19989568680No
160123081154.087.3243.7Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Stephen M Smith, Thomas E NicholsNeuroimage200918501637Yes
160211531153.038.1338.1Determination of minimum inhibitory concentrations. J M AndrewsJ. Antimicrob. Chemother.200111420333Yes
160311521152.040.6940.7DNA topoisomerases. J C WangAnnu. Rev. Biochem.19852992360No
160411521152.00.00.0Dynamic properties of mammalian skeletal muscles. R I ClosePhysiol. Rev.19724256989No
160523041152.092.4946.2A rapid boiling method for the preparation of bacterial plasmids. D S Holmes, M QuigleyAnal. Biochem.19816269464Yes
160623041152.0118.5259.3Assays of glutathione peroxidase. L Flohé, W A GünzlerMeth. Enzymol.19846727659Yes
160711521152.029.4829.5Mechanisms of bone metastasis. G David RoodmanN. Engl. J. Med.200415084698No
160811511151.038.1138.1Trophic factors and neuronal survival. Y A BardeNeuron19892697237No
160911511151.029.3229.3Tumor metastasis: mechanistic insights and clinical challenges. Patricia S SteegNat. Med.200616892035No
161023011150.587.7543.9Molecular mechanisms and clinical applications of angiogenesis. Peter Carmeliet, Rakesh K JainNature201121593862No
161157451149.0156.9131.4Site-directed mutagenesis by overlap extension using the polymerase chain reaction. S N Ho, H D Hunt, R M Horton, J K Pullen, L R PeaseGene19892744487Yes
161211491149.023.5723.6Ubiquitin-dependent protein degradation. M HochstrasserAnnu. Rev. Genet.19968982460No
161334451148.30.00.0A rapid method for the isolation of functional thymus-derived murine lymphocytes. M H Julius, E Simpson, L A HerzenbergEur. J. Immunol.19734587740Yes
161422941147.089.644.8Performing the exact test of Hardy-Weinberg proportion for multiple alleles. S W Guo, E A ThompsonBiometrics19921637966Yes
161522941147.060.030.0Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. T Miyashita, J C ReedCell19957834749Yes
161611461146.045.8445.8Validation of a decisional conflict scale. A M O'ConnorMed Decis Making19957898294Yes
161711461146.030.1930.2The molecular logic of endocannabinoid signalling. Daniele PiomelliNat. Rev. Neurosci.200314595399No
161811451145.027.1327.1The ubiquitin-proteasome proteolytic pathway. A CiechanoverCell19947923371No
161911451145.044.8944.9Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? George A BonannoAm Psychol200414736317No
162034351145.0111.7637.3Optimization by simulated annealing. S Kirkpatrick, C D Gelatt, M P VecchiScience198317813860Yes
162122901145.096.9548.5Neurocircuitry of addiction. George F Koob, Nora D VolkowNeuropsychopharmacology201019710631No
162222891144.553.4126.7New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. R D Gietz, A SuginoGene19883073106Yes
162311441144.045.2945.3The atom economy--a search for synthetic efficiency. B M TrostScience19911962206Yes
162468631143.8319.353.2Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. L C Green, D A Wagner, J Glogowski, P L Skipper, J S Wishnok, S R TannenbaumAnal. Biochem.19827181105Yes
162511431143.00.00.0Synaptic density in human frontal cortex - developmental changes and effects of aging. P R HuttenlocherBrain Res.1979427544Yes
162611431143.051.8351.8The case-crossover design: a method for studying transient effects on the risk of acute events. M MaclureAm. J. Epidemiol.19911985444Yes
162722851142.563.4531.7Multipoint quantitative-trait linkage analysis in general pedigrees. L Almasy, J BlangeroAm. J. Hum. Genet.19989545414Yes
162822851142.561.1230.6The incidence of congenital heart disease. Julien I E Hoffman, Samuel KaplanJ. Am. Coll. Cardiol.200212084585No
162911421142.064.0464.0Neurogenetic adaptive mechanisms in alcoholism. C R CloningerScience19872882604Yes
163022841142.075.5737.8An information-maximization approach to blind separation and blind deconvolution. A J Bell, T J SejnowskiNeural Comput19957584893Yes
163122831141.557.2228.6Inhibitors of mammalian G1 cyclin-dependent kinases. C J Sherr, J M RobertsGenes Dev.19957758941No
163211411141.00.00.0Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. A F HabeebAnal. Biochem.19664161471Yes
163345641141.0221.8555.5Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanJ Clin Epidemiol200919631508No
163445631140.80.00.0Antibiotic susceptibility testing by a standardized single disk method. A W Bauer, W M Kirby, J C Sherris, M TurckAm. J. Clin. Pathol.19665325707Yes
163522791139.562.0331.0A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. L Buck, R AxelCell19911840504Yes
163611391139.00.00.0Disconnexion syndromes in animals and man. I. N GeschwindBrain19655318481No
163711391139.022.6822.7The DNA methyltransferases of mammals. T H BestorHum. Mol. Genet.200011005794No
163822781139.086.8443.4From best evidence to best practice: effective implementation of change in patients' care. Richard Grol, Jeremy GrimshawLancet200314568747No
163945531138.2128.5332.1The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Konstantin Arnold, Lorenza Bordoli, Jürgen Kopp, Torsten SchwedeBioinformatics200616301204Yes
164045501137.5342.385.6Prevalence of childhood and adult obesity in the United States, 2011-2012. Cynthia L Ogden, Margaret D Carroll, Brian K Kit, Katherine M FlegalJAMA201424570244Yes
164111371137.046.4946.5Polycystic ovary syndrome. S FranksN. Engl. J. Med.19957651477No
164211371137.037.6337.6Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Michael F HolickAm. J. Clin. Nutr.200415585788No
164311371137.046.1546.1Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Leonardo PantoniLancet Neurol201020610345No
164422701135.064.1432.1Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. F Q Schafer, G R BuettnerFree Radic. Biol. Med.200111368918No
164511351135.00.00.0Application of a microtechnique to viral serological investigations. J L SEVERJ. Immunol.196213910995Yes
164622691134.556.7428.4Neurotrophins: roles in neuronal development and function. E J Huang, L F ReichardtAnnu. Rev. Neurosci.200111520916No
164722681134.094.5947.3The efficiency of systematic sampling in stereology and its prediction. H J Gundersen, E B JensenJ Microsc19873430576Yes
164811341134.00.00.0Interhemispheric differences in the localization of psychological processes in man. B MilnerBr. Med. Bull.19714937273No
164922681134.050.4825.2Mutations affecting segment number and polarity in Drosophila. C Nüsslein-Volhard, E WieschausNature19806776413Yes
165011341134.030.7930.8Neuronal synchrony: a versatile code for the definition of relations? W SingerNeuron199910677026No
165111341134.024.3224.3Epithelial-mesenchymal transitions in development and pathologies. Jean Paul ThieryCurr. Opin. Cell Biol.200314644200No
165222681134.079.339.6miRBase: integrating microRNA annotation and deep-sequencing data. Ana Kozomara, Sam Griffiths-JonesNucleic Acids Res.201121037258Yes
165322671133.50.00.0The structure of coping. L I Pearlin, C SchoolerJ Health Soc Behav1978649936Yes
165422671133.50.00.0Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. M Grunstein, D S HognessProc. Natl. Acad. Sci. U.S.A.19751105573Yes
165522671133.567.3233.7A scaling normalization method for differential expression analysis of RNA-seq data. Mark D Robinson, Alicia OshlackGenome Biol.201020196867Yes
165622661133.063.7731.9Steatohepatitis: a tale of two "hits"? C P Day, O F JamesGastroenterology19989547102No
165722661133.060.1230.1The pathophysiology and treatment of sepsis. Richard S Hotchkiss, Irene E KarlN. Engl. J. Med.200312519925No
165811331133.040.9340.9PsychoPy--Psychophysics software in Python. Jonathan W PeirceJ. Neurosci. Methods200717254636Yes
165911321132.066.3766.4The contribution of low birth weight to infant mortality and childhood morbidity. M C McCormickN. Engl. J. Med.19853880598No
166033941131.3107.0935.7TCS: a computer program to estimate gene genealogies. M Clement, D Posada, K A CrandallMol. Ecol.200011050560Yes
166111311131.025.1625.2Altering the genome by homologous recombination. M R CapecchiScience19892660260No
166211301130.038.7638.8Trail Making Test A and B: normative data stratified by age and education. Tom N TombaughArch Clin Neuropsychol200415010086Yes
166311291129.00.00.0Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. B HilleJ. Gen. Physiol.1977300786Yes
166411291129.034.1534.1Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. G von HeijneJ. Mol. Biol.19921593632Yes
166511291129.039.6639.7DNA topoisomerase poisons as antitumor drugs. L F LiuAnnu. Rev. Biochem.19892549853No
166611291129.026.5726.6Stability and flexibility of epigenetic gene regulation in mammalian development. Wolf ReikNature200717522676No
166711281128.030.730.7Molecular basis of long-term plasticity underlying addiction. E J NestlerNat. Rev. Neurosci.200111252991No
166822561128.084.6742.3Alzheimer's disease. Henry W Querfurth, Frank M LaFerlaN. Engl. J. Med.201020107219No
166922551127.566.1433.1Malignant gliomas in adults. Patrick Y Wen, Santosh KesariN. Engl. J. Med.200818669428No
167011271127.00.00.0Stability of proteins: small globular proteins. P L PrivalovAdv. Protein Chem.197944431No
167122541127.059.2529.6An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. A A Beg, D BaltimoreScience19968864118Yes
167211271127.022.5122.5Chromatin modification and epigenetic reprogramming in mammalian development. En LiNat. Rev. Genet.200212209141No
167311271127.00.00.0Discharge patterns and functional organization of mammalian retina. S W KUFFLERJ. Neurophysiol.195313035466Yes
167422541127.052.2726.1Intrinsically unstructured proteins and their functions. H Jane Dyson, Peter E WrightNat. Rev. Mol. Cell Biol.200515738986No
167522531126.50.00.0A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. J E TILL, E A McCULLOCHRadiat. Res.196113776896Yes
167622521126.0113.6356.8The mini-mental state examination: a comprehensive review. T N Tombaugh, N J McIntyreJ Am Geriatr Soc19921512391No
167722521126.085.2842.6Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. K B Mullis, F A FaloonaMeth. Enzymol.19873431465Yes
167811261126.033.4233.4The amygdala modulates the consolidation of memories of emotionally arousing experiences. James L McGaughAnnu. Rev. Neurosci.200415217324No
167922511125.565.3132.7Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. H Cai, D G HarrisonCirc. Res.200011073878No
168022511125.564.0732.0Unravelling the pathogenesis of inflammatory bowel disease. R J Xavier, D K PodolskyNature200717653185No
168122501125.00.00.0Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. A J Berk, P A SharpCell1977922889Yes
168211251125.044.3744.4Evidence for a central component of post-injury pain hypersensitivity. C J WoolfNature19836656869Yes
168311251125.039.839.8Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. J A BeavoPhysiol. Rev.19957480160No
168422501125.066.8333.4The biology of vascular endothelial growth factor. N Ferrara, T Davis-SmythEndocr. Rev.19979034784No
168511251125.028.7828.8Hematopoietic stem-cell transplantation. Edward A CopelanN. Engl. J. Med.200616641398No
168611241124.035.1735.2Steroid receptor regulated transcription of specific genes and gene networks. K R YamamotoAnnu. Rev. Genet.19853909942No
168711241124.00.00.0The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models. R C LewontinGenetics196417248194Yes
168822481124.072.0536.0Multiple sclerosis. Alastair Compston, Alasdair ColesLancet200818970977Yes
168911231123.032.0632.1A molecular view of microbial diversity and the biosphere. N R PaceScience19979115194No
169022451122.559.4929.7Lipopolysaccharide endotoxins. Christian R H Raetz, Chris WhitfieldAnnu. Rev. Biochem.200212045108No
169122451122.551.9326.0Development by self-digestion: molecular mechanisms and biological functions of autophagy. Beth Levine, Daniel J KlionskyDev. Cell200415068787No
169211221122.00.00.0Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. A FleckensteinAnnu. Rev. Pharmacol. Toxicol.1977326161No
169311221122.037.637.6Capacitative calcium entry revisited. J W PutneyCell Calcium19901965707No
169411211121.043.7643.8Gene flow and the geographic structure of natural populations. M SlatkinScience19873576198Yes
169511211121.072.3572.3The structure and properties of the sense of coherence scale. A AntonovskySoc Sci Med19938480217Yes
169611211121.042.5342.5Strong localization of photons in certain disordered dielectric superlattices. JohnPhys. Rev. Lett.198710034761Yes
169722411120.549.2824.6Cancer genes and the pathways they control. Bert Vogelstein, Kenneth W KinzlerNat. Med.200415286780No
169822411120.577.6238.8Autophagy: renovation of cells and tissues. Noboru Mizushima, Masaaki KomatsuCell201122078875No
169911201120.00.00.0Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. C A BarnesJ Comp Physiol Psychol1979221551Yes
170011201120.00.00.0The oxidation of ribonuclease with performic acid. C H HIRSJ. Biol. Chem.195613319283Yes
170111201120.032.4732.5The failing heart--an engine out of fuel. Stefan NeubauerN. Engl. J. Med.200717360992No
170211201120.033.7133.7Using circular dichroism spectra to estimate protein secondary structure. Norma J GreenfieldNat Protoc200617406547Yes
170311201120.045.8445.8Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Joseph J VolpeLancet Neurol200919081519No
170467181119.7198.4933.1Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. D J Slamon, G M Clark, S G Wong, W J Levin, A Ullrich, W L McGuireScience19873798106Yes
170522381119.00.00.0New Giemsa method for the differential staining of sister chromatids. P Perry, S WolffNature19744138930Yes
170611191119.044.744.7G proteins and dual control of adenylate cyclase. A G GilmanCell19846321035Yes
170711191119.021.5721.6Protein modification by SUMO. Erica S JohnsonAnnu. Rev. Biochem.200415189146No
170822371118.568.134.0Obesity. David W Haslam, W Philip T JamesLancet200516198769No
170922361118.00.00.0Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. M Mihara, M UchiyamaAnal. Biochem.1978655387Yes
171011181118.00.00.0PLASTIC EMBEDDING MIXTURES FOR USE IN ELECTRON MICROSCOPY. H H MOLLENHAUERStain Technol196414127791Yes
171111161116.027.427.4DNA in a material world. Nadrian C SeemanNature200312540916No
171233481116.091.530.5Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Claus Lindbjerg Andersen, Jens Ledet Jensen, Torben Falck ØrntoftCancer Res.200415289330Yes
171311161116.032.6132.6Myeloperoxidase: friend and foe. Seymour J KlebanoffJ. Leukoc. Biol.200515689384No
171422301115.065.9133.0Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. E S Lander, D BotsteinGenetics19892563713Yes
171511151115.045.6145.6The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat. L W SwansonBrain Res. Bull.19826816390Yes
171611141114.050.0350.0Aging, natural death, and the compression of morbidity. J F FriesN. Engl. J. Med.19807383070Yes
171711141114.038.0438.0Molecular bases of the acute coronary syndromes. P LibbyCirculation19957758192No
171822261113.068.7634.4The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. P Angel, M KarinBiochim. Biophys. Acta19911751545No
171911131113.043.0643.1Efficient analysis of experimental observations. W J DixonAnnu. Rev. Pharmacol. Toxicol.19807387124Yes
172011131113.027.927.9The NCI60 human tumour cell line anticancer drug screen. Robert H ShoemakerNat. Rev. Cancer200616990858No
172122231111.50.00.0Synchronization of Plasmodium falciparum erythrocytic stages in culture. C Lambros, J P VanderbergJ. Parasitol.1979383936Yes
172211111111.031.8331.8Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology. B Winkel-ShirleyPlant Physiol.200111402179No
172311101110.00.00.0Mate selection-a selection for a handicap. A ZahaviJ. Theor. Biol.19751195756Yes
172422191109.582.9241.5Biochemistry of multidrug resistance mediated by the multidrug transporter. M M Gottesman, I PastanAnnu. Rev. Biochem.19938102521No
172522191109.562.8231.4Interneurons of the hippocampus. T F Freund, G BuzsákiHippocampus19968915675No
172611091109.073.2273.2Chronic illness as biographical disruption. M BurySociol Health Illn198210260456Yes
172711081108.034.6534.6Hemispheric asymmetry reduction in older adults: the HAROLD model. Roberto CabezaPsychol Aging200211931290No
172844291107.2250.3362.6jModelTest 2: more models, new heuristics and parallel computing. Diego Darriba, Guillermo L Taboada, Ramón Doallo, David PosadaNat. Methods201222847109Yes
172911061106.045.1845.2Metalloproteinases and their inhibitors in matrix remodeling. L M MatrisianTrends Genet.19902132731No
173033181106.0103.6434.5Cognitive and emotional influences in anterior cingulate cortex. Bush, Luu, PosnerTrends Cogn. Sci. (Regul. Ed.)200010827444Yes
173111051105.00.00.0ATPase activity of myosin correlated with speed of muscle shortening. M BárányJ. Gen. Physiol.19674227924Yes
173222101105.093.5746.8Shifting the genomic gold standard for the prokaryotic species definition. Michael Richter, Ramon Rosselló-MóraProc. Natl. Acad. Sci. U.S.A.200919855009Yes
173344191104.8148.8437.2Comorbidity measures for use with administrative data. A Elixhauser, C Steiner, D R Harris, R M CoffeyMed Care19989431328Yes
173411041104.025.7625.8Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. R I MorimotoGenes Dev.19989869631No
173511041104.045.5845.6A new automated colorimetric method for measuring total oxidant status. Ozcan ErelClin. Biochem.200516214125Yes
173611031103.037.6537.6Redox signaling: nitrosylation and related target interactions of nitric oxide. J S StamlerCell19947923362No
173711031103.041.7941.8Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. M Robin DiMatteoMed Care200415076819Yes
173811021102.030.9931.0Regulation of differentiation of vascular smooth muscle cells. G K OwensPhysiol. Rev.19957624392No
173911021102.031.5231.5The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. H MaedaAdv. Enzyme Regul.200111384745No
174011011101.042.342.3Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. M D MainesFASEB J.19883290025No
174122021101.065.8532.9Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. M A Nitsche, W PaulusJ. Physiol. (Lond.)200010990547Yes
174222011100.552.4626.2The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. M S Brown, J L GoldsteinCell19979150132No
174311001100.00.00.0Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. W H OldendorfAm. J. Physiol.19715124307Yes
174477001100.0283.2240.5Cancer statistics, 2008. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Yongping Hao, Jiaquan Xu, Taylor Murray, Michael J ThunCA Cancer J Clin200818287387Yes
174521991099.543.3421.7Rab proteins as membrane organizers. M Zerial, H McBrideNat. Rev. Mol. Cell Biol.200111252952No
174621991099.548.6624.3Wnt signalling in stem cells and cancer. Tannishtha Reya, Hans CleversNature200515829953No
174710991099.029.1429.1Neurotrophin-regulated signalling pathways. Louis F ReichardtPhilos. Trans. R. Soc. Lond., B, Biol. Sci.200616939974No
174810981098.050.9651.0Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. C E MogensenN. Engl. J. Med.19846690964Yes
174910981098.023.8423.8NK cell receptors. L L LanierAnnu. Rev. Immunol.19989597134No
175010981098.024.424.4Macromolecular crowding: obvious but underappreciated. R J EllisTrends Biochem. Sci.200111590012No
175110981098.030.7730.8Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). K M FoxLancet200313678872Yes
175210981098.046.0146.0Cognitive reserve. Yaakov SternNeuropsychologia200919467352No
175310971097.031.4431.4Oxidative stress in Parkinson's disease. Peter JennerAnn. Neurol.200312666096No
175421941097.00.00.0Convergent and discriminant validation by the multitrait-multimethod matrix. D T CAMPBELL, D W FISKEPsychol Bull195913634291Yes
175510971097.034.4434.4External validity of randomised controlled trials: "to whom do the results of this trial apply?". Peter M RothwellLancet200515639683Yes
175610971097.034.2434.2P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation. Berk HessJ Chem Theory Comput200826619985Yes
175721931096.552.4426.2Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. J M Kyriakis, J AvruchPhysiol. Rev.200111274345No
175810961096.035.9135.9A note on robust variance estimation for cluster-correlated data. R L WilliamsBiometrics200010877330Yes
175943821095.5128.7532.2Most mammalian mRNAs are conserved targets of microRNAs. Robin C Friedman, Kyle Kai-How Farh, Christopher B Burge, David P BartelGenome Res.200918955434Yes
176010951095.035.1435.1Thioredoxin and glutaredoxin systems. A HolmgrenJ. Biol. Chem.19892668278No
176110951095.057.8457.8Physiological aspects of primary hypertension. B FolkowPhysiol. Rev.19826461865No
176210951095.022.2922.3Regulatory T cells: key controllers of immunologic self-tolerance. S SakaguchiCell200010850488No
176343791094.8164.3541.1The validity of the Hospital Anxiety and Depression Scale. An updated literature review. Ingvar Bjelland, Alv A Dahl, Tone Tangen Haug, Dag NeckelmannJ Psychosom Res200211832252No
176410941094.00.00.0The recurrence of intracranial meningiomas after surgical treatment. D SIMPSONJ. Neurol. Neurosurg. Psychiatry195713406590Yes
176510941094.00.00.0Structural considerations in the interaction of DNA and acridines. L S LERMANJ. Mol. Biol.196113761054Yes
176621871093.50.00.0New method for quantitative determination of uronic acids. N Blumenkrantz, G Asboe-HansenAnal. Biochem.19734269305Yes
176743721093.0105.5226.4MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi MiyataNucleic Acids Res.200212136088Yes
176810931093.054.4754.5Doxil®--the first FDA-approved nano-drug: lessons learned. Yechezkel BarenholzJ Control Release201222484195No
176954581091.60.00.0STUDIES OF ILLNESS IN THE AGED. THE INDEX OF ADL: A STANDARDIZED MEASURE OF BIOLOGICAL AND PSYCHOSOCIAL FUNCTION. S KATZ, A B FORD, R W MOSKOWITZ, B A JACKSON, M W JAFFEJAMA196314044222Yes
177043661091.5263.7165.9The Satisfaction With Life Scale. E Diener, R A Emmons, R J Larsen, S GriffinJ Pers Assess198516367493Yes
177110911091.042.642.6The functional gastrointestinal disorders and the Rome III process. Douglas A DrossmanGastroenterology200616678553No
177221821091.086.5143.3Density functionals with broad applicability in chemistry. Yan Zhao, Donald G TruhlarAcc. Chem. Res.200818186612Yes
177310901090.021.621.6The snail superfamily of zinc-finger transcription factors. M Angela NietoNat. Rev. Mol. Cell Biol.200211994736No
177421781089.00.00.0The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. J O'Keefe, J DostrovskyBrain Res.19715124915Yes
177510891089.049.449.4Frontal-subcortical circuits and human behavior. J L CummingsArch. Neurol.19938352676No
177610891089.027.2727.3Protein misfolding, evolution and disease. C M DobsonTrends Biochem. Sci.199910470028No
177710891089.029.9630.0Refined structure of the nicotinic acetylcholine receptor at 4A resolution. Nigel UnwinJ. Mol. Biol.200515701510Yes
177821771088.50.00.0A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. J A Horne, O OstbergInt J Chronobiol19761027738Yes
177910881088.00.00.0Stimulated acoustic emissions from within the human auditory system. D T KempJ. Acoust. Soc. Am.1978744838Yes
178010881088.033.9834.0Rapid and sensitive sequence comparison with FASTP and FASTA. W R PearsonMeth. Enzymol.19902156132Yes
178110881088.060.060.0A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. D J SchuirmannJ Pharmacokinet Biopharm19873450848Yes
178221761088.0164.582.2Rating systems in the evaluation of knee ligament injuries. Y Tegner, J LysholmClin. Orthop. Relat. Res.19854028566Yes
178310871087.00.00.0CHROMATOGRAPHIC SEPARATION OF HUMAN BRAIN GANGLIOSIDES. L SVENNERHOLMJ. Neurochem.196314066623Yes
178410871087.048.3448.3Falls in older people: epidemiology, risk factors and strategies for prevention. Laurence Z RubensteinAge Ageing200616926202No
178532571085.794.9731.7Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. B Fischl, M I Sereno, A M DaleNeuroimage19999931269Yes
178610851085.00.00.0Estimability and estimation in case-referent studies. O MiettinenAm. J. Epidemiol.19761251836Yes
178710851085.031.7331.7The use of nanocrystals in biological detection. Paul AlivisatosNat. Biotechnol.200414704706Yes
178821701085.076.038.0Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Sally S Dickerson, Margaret E KemenyPsychol Bull200415122924Yes
178910851085.037.7737.8The debate over dopamine's role in reward: the case for incentive salience. Kent C BerridgePsychopharmacology (Berl.)200717072591No
179010851085.039.4839.5Surface plasmon resonance sensors for detection of chemical and biological species. Jirí HomolaChem. Rev.200818229953No
179121691084.545.7722.9Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. C Li, W H WongProc. Natl. Acad. Sci. U.S.A.200111134512Yes
179243371084.2204.4651.1Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Franz Faul, Edgar Erdfelder, Axel Buchner, Albert-Georg LangBehav Res Methods200919897823Yes
179310841084.046.3346.3Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. N KriegerAm J Public Health19921566949Yes
179410841084.00.00.0Isolated removal of hypothalamic or other brain nuclei of the rat. M PalkovitsBrain Res.19734747772Yes
179510841084.00.00.0The statistical analysis of enzyme kinetic data. W W ClelandAdv. Enzymol. Relat. Areas Mol. Biol.19674881884No
179610841084.027.2627.3Cancer of the ovary. Stephen A CannistraN. Engl. J. Med.200415590954No
179721681084.054.2527.1Cancer metastasis: building a framework. Gaorav P Gupta, Joan MassaguéCell200617110329No
179821671083.585.0442.5Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. G R Gibson, M B RoberfroidJ. Nutr.19957782892No
179910831083.043.2543.2Neurotransmitters and neuromodulators in the basal ganglia. A M GraybielTrends Neurosci.19901695398No
180010831083.039.3339.3Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. A FabiatoAm. J. Physiol.19836346892No
180110831083.031.031.0Functions of ceramide in coordinating cellular responses to stress. Y A HannunScience19968943189No
180221651082.569.8334.9ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. B Ravel, M NewvilleJ Synchrotron Radiat200515968136Yes
180321641082.070.7435.4The expanding universe of T-cell subsets: Th1, Th2 and more. T R Mosmann, S SadImmunol. Today19968820272No
180410821082.036.9136.9A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. J EngelEpilepsia200111422340Yes
180521631081.50.00.0The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. A E Bolton, W M HunterBiochem. J.19734733239Yes
180621621081.00.00.0THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES. T OMURA, R SATOJ. Biol. Chem.196414209972Yes
180721611080.577.4138.7EQ-5D: a measure of health status from the EuroQol Group. R Rabin, F de CharroAnn. Med.200111491192No
180821611080.550.1425.1Short-term synaptic plasticity. Robert S Zucker, Wade G RegehrAnnu. Rev. Physiol.200211826273No
180921601080.0104.4752.2A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. C M Tsai, C E FraschAnal. Biochem.19826176137Yes
181010801080.019.6219.6The economics of ribosome biosynthesis in yeast. J R WarnerTrends Biochem. Sci.199910542411No
181110801080.026.7926.8Critical period plasticity in local cortical circuits. Takao K HenschNat. Rev. Neurosci.200516261181No
181221581079.083.0441.5Polyamines. C W Tabor, H TaborAnnu. Rev. Biochem.19846206782No
181310791079.035.6635.7The epidemiology of venous thromboembolism. Richard H WhiteCirculation200312814979No
181432361078.796.3732.1Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. M A Frohman, M K Dush, G R MartinProc. Natl. Acad. Sci. U.S.A.19882461560Yes
181521571078.583.6541.8Functional architecture of basal ganglia circuits: neural substrates of parallel processing. G E Alexander, M D CrutcherTrends Neurosci.19901695401No
181621561078.050.0525.0The molecular biology of axon guidance. M Tessier-Lavigne, C S GoodmanScience19968895455No
181710781078.021.5421.5Surpassing the lateral resolution limit by a factor of two using structured illumination microscopy. M G GustafssonJ Microsc200010810003Yes
181810781078.019.4819.5Cancer. Addiction to oncogenes--the Achilles heal of cancer. I Bernard WeinsteinScience200212098689No
181910781078.042.9142.9Social relationships and health. Sheldon CohenAm Psychol200415554821No
182010771077.00.00.0Microbial ecology of the gastrointestinal tract. D C SavageAnnu. Rev. Microbiol.1977334036No
182121521076.059.6729.8The MAPK signaling cascade. R Seger, E G KrebsFASEB J.19957601337No
182210761076.047.5747.6Phase retrieval algorithms: a comparison. J R FienupAppl Opt198220396114Yes
182310751075.00.00.0Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. A KrishanJ. Cell Biol.197549354Yes
182432201073.388.6429.5The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. S K Hanks, A M Quinn, T HunterScience19883291115No
182521451072.569.8334.9Materials for electrochemical capacitors. Patrice Simon, Yury GogotsiNat Mater200818956000Yes
182621451072.553.2926.6NMR View: A computer program for the visualization and analysis of NMR data. B A Johnson, R A BlevinsJ. Biomol. NMR199422911360Yes
182742881072.00.00.0A rating scale for mania: reliability, validity and sensitivity. R C Young, J T Biggs, V E Ziegler, D A MeyerBr J Psychiatry1978728692Yes
182821441072.00.00.0Computed circular dichroism spectra for the evaluation of protein conformation. N Greenfield, G D FasmanBiochemistry19695346390Yes
182910721072.025.1725.2Endocytosis and molecular sorting. I MellmanAnnu. Rev. Cell Dev. Biol.19968970738No
183010721072.040.2440.2Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements. James J P StewartJ Mol Model200717828561Yes
183121431071.576.1238.1Angiogenesis. J Folkman, Y ShingJ. Biol. Chem.19921375931No
183221431071.545.0422.5Genetic transformation of Drosophila with transposable element vectors. G M Rubin, A C SpradlingScience19826289436Yes
183310711071.00.00.0The mechanism of muscular contraction. H E HuxleyScience19694181952No
183410711071.043.9544.0The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. G R BuettnerArch. Biochem. Biophys.19938434935No
183521421071.00.00.0Junctional complexes in various epithelia. M G FARQUHAR, G E PALADEJ. Cell Biol.196313944428Yes
183621401070.0108.5354.3Assessment of eating disorders: interview or self-report questionnaire? C G Fairburn, S J BeglinInt J Eat Disord19947866415Yes
183710701070.045.9145.9Dual-task interference in simple tasks: data and theory. H PashlerPsychol Bull19947972591No
183810701070.031.7731.8Drug-induced prolongation of the QT interval. Dan M RodenN. Engl. J. Med.200414999113No
183932041068.00.00.0Hydroperoxide metabolism in mammalian organs. B Chance, H Sies, A BoverisPhysiol. Rev.197937532Yes
184010681068.030.0630.1Developmental cell death: morphological diversity and multiple mechanisms. P G ClarkeAnat. Embryol.19902186664No
184110681068.030.8730.9The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. M TakeichiDevelopment19883048970No
184210681068.060.0260.0Mood and memory. G H BowerAm Psychol19817224324Yes
184310681068.042.7442.7Domino Reactions in Organic Synthesis. Lutz F. TietzeChem. Rev.199611848746Yes
184410681068.033.2233.2Integration, scaling, space-group assignment and post-refinement. Wolfgang KabschActa Crystallogr. D Biol. Crystallogr.201020124693Yes
184521351067.50.00.0A scaled version of the General Health Questionnaire. D P Goldberg, V F HillierPsychol Med1979424481Yes
184632011067.061.7320.6A system for stable expression of short interfering RNAs in mammalian cells. Thijn R Brummelkamp, René Bernards, Reuven AgamiScience200211910072Yes
184721331066.50.00.03' non-coding region sequences in eukaryotic messenger RNA. N J Proudfoot, G G BrownleeNature1976822353Yes
184821331066.575.1637.6Mortality by cause for eight regions of the world: Global Burden of Disease Study. C J Murray, A D LopezLancet19979142060Yes
184910661066.032.8432.8Genetic consequences of climatic oscillations in the Quaternary. G M HewittPhilos. Trans. R. Soc. Lond., B, Biol. Sci.200415101575No
185021311065.576.4338.2Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. C J Murray, A D LopezLancet19979164317Yes
185110651065.048.1148.1Recent advances in the biochemistry of polyamines in eukaryotes. A E PeggBiochem. J.19863087344No
185210651065.026.6626.7Autophagy: from phenomenology to molecular understanding in less than a decade. Daniel J KlionskyNat. Rev. Mol. Cell Biol.200717712358No
185395801064.4359.3539.9The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. D V Sheehan, Y Lecrubier, K H Sheehan, P Amorim, J Janavs, E Weiller, T Hergueta, R Baker, G C DunbarJ Clin Psychiatry19989881538No
185421271063.552.2226.1LTP and LTD: an embarrassment of riches. Robert C Malenka, Mark F BearNeuron200415450156No
185510631063.039.1439.1Systemic lupus erythematosus. George C TsokosN. Engl. J. Med.201122129255No
185663751062.5244.9940.8New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Stéphane Guindon, Jean-François Dufayard, Vincent Lefort, Maria Anisimova, Wim Hordijk, Olivier GascuelSyst. Biol.201020525638Yes
185710621062.094.1494.1The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. F C EwaldClin. Orthop. Relat. Res.19892805502Yes
185810611061.027.3227.3E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. J R NevinsScience19921411535Yes
185921221061.055.4627.7Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. P J Mitchell, R TjianScience19892667136No
186010611061.075.3975.4Presynaptic regulation of the release of catecholamines. S Z LangerPharmacol. Rev.19806267618Yes
186121221061.093.7446.9The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. R Doll, R PetoJ. Natl. Cancer Inst.19817017215No
186221221061.059.2629.6NF-kappa B: ten years after. P A Baeuerle, D BaltimoreCell19968858144No
186321211060.50.00.0Mutations of Bacteria from Virus Sensitivity to Virus Resistance. S E Luria, M DelbrückGenetics194317247100Yes
186431811060.375.4925.2A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. R Medzhitov, P Preston-Hurlburt, C A JanewayNature19979237759Yes
186521201060.067.2433.6Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. I Issemann, S GreenNature19902129546Yes
186642381059.50.00.0A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. M A Markwell, S M Haas, L L Bieber, N E TolbertAnal. Biochem.197898070Yes
186731761058.781.6527.2Telomeres shorten during ageing of human fibroblasts. C B Harley, A B Futcher, C W GreiderNature19902342578Yes
186821171058.571.7835.9Lipid rafts as a membrane-organizing principle. Daniel Lingwood, Kai SimonsScience201020044567No
186910581058.045.4545.5Plasma perspective on strong field multiphoton ionization. CorkumPhys. Rev. Lett.199310054556Yes
187010571057.055.7155.7A structured interview guide for the Hamilton Depression Rating Scale. J B WilliamsArch. Gen. Psychiatry19883395203Yes
187110571057.025.8225.8Drug discovery: a historical perspective. J DrewsScience200010720314No
187210571057.021.1221.1SUMO: a history of modification. Ronald T HayMol. Cell200515808504No
187310571057.026.9226.9Mitochondria: dynamic organelles in disease, aging, and development. David C ChanCell200616814712No
187431691056.380.7826.9Osteoclast differentiation and activation. William J Boyle, W Scott Simonet, David L LaceyNature200312748652No
187510561056.046.546.5Metallothionein. D H HamerAnnu. Rev. Biochem.19863527054No
187610561056.00.00.0RNA-dependent DNA polymerase in virions of RNA tumour viruses. D BaltimoreNature19704316300Yes
187710561056.036.8236.8Circuitry and functional aspects of the insular lobe in primates including humans. J R AugustineBrain Res. Brain Res. Rev.19968957561No
187810561056.027.3327.3Hyaluronan: from extracellular glue to pericellular cue. Bryan P TooleNat. Rev. Cancer200415229478No
187942231055.8114.0828.5Quantitative monitoring of gene expression patterns with a complementary DNA microarray. M Schena, D Shalon, R W Davis, P O BrownScience19957569999Yes
188021111055.580.9240.5The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. J D Hayes, D J PulfordCrit. Rev. Biochem. Mol. Biol.19958770536No
188110551055.033.7733.8Hydrogels for biomedical applications. Allan S HoffmanAdv. Drug Deliv. Rev.200211755703No
188210541054.019.8219.8Clonal selection and learning in the antibody system. K RajewskyNature19968657279No
188310541054.029.5529.6Optimal experimental design for event-related fMRI. A M DaleHum Brain Mapp199910524601Yes
188410541054.036.4136.4Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. E B HunzikerOsteoarthr. Cartil.200212056848No
188510541054.00.00.0THE RELATION OF RECOMBINATION TO MUTATIONAL ADVANCE. H J MULLERMutat. Res.196414195748Yes
188621071053.545.9823.0Prediction of complete gene structures in human genomic DNA. C Burge, S KarlinJ. Mol. Biol.19979149143Yes
188731601053.389.9430.0Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Christopher R Genovese, Nicole A Lazar, Thomas NicholsNeuroimage200211906227Yes
188821061053.044.4222.2Oncogenic kinase signalling. P Blume-Jensen, T HunterNature200111357143No
188910531053.041.9341.9Formation of glasses from liquids and biopolymers. C A AngellScience199517770101Yes
189010521052.054.154.1The role of hormone receptors and GTP-regulatory proteins in membrane transduction. M RodbellNature19806101906Yes
189110521052.032.4732.5Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. M KozakMicrobiol. Rev.19836343825No
189210521052.026.2126.2The ATP synthase--a splendid molecular machine. P D BoyerAnnu. Rev. Biochem.19979242922No
189310521052.026.9126.9HIF-1: mediator of physiological and pathophysiological responses to hypoxia. G L SemenzaJ. Appl. Physiol.200010749844No
189421031051.552.2826.1Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Joshua E Elias, Steven P GygiNat. Methods200717327847Yes
189510511051.00.00.0The theory and applications of the exchange of inert gas at the lungs and tissues. S S KETYPharmacol. Rev.195114833874Yes
189621011050.552.7526.4Microtubules as a target for anticancer drugs. Mary Ann Jordan, Leslie WilsonNat. Rev. Cancer200415057285No
189721001050.061.0230.5Molecular beacons: probes that fluoresce upon hybridization. S Tyagi, F R KramerNat. Biotechnol.19969630890Yes
189821001050.045.1522.6Autophagy as a regulated pathway of cellular degradation. D J Klionsky, S D EmrScience200011099404No
189910501050.044.0944.1Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Berislav V ZlokovicNat. Rev. Neurosci.201122048062No
190010491049.00.00.0A graphic method for the determination and presentation of binding parameters in a complex system. H E RosenthalAnal. Biochem.19676048188Yes
190110491049.028.5428.5Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. W D SniderCell19948205613No
190210491049.024.9124.9Searching for genetic determinants in the new millennium. N J RischNature200010866211No
190310491049.024.9524.9The many faces of macrophage activation. David M MosserJ. Leukoc. Biol.200312554797No
190410491049.00.00.0The measurement of volume changes in human limbs. R J WHITNEYJ. Physiol. (Lond.)195313085295Yes
190520971048.542.7221.4A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. D Tautz, C PfeifleChromosoma19892476281Yes
190620971048.548.2424.1A guided tour into subcellular colocalization analysis in light microscopy. S Bolte, F P CordelièresJ Microsc200617210054Yes
190710481048.024.0424.0Natively unfolded proteins: a point where biology waits for physics. Vladimir N UverskyProtein Sci.200211910019No
190820961048.00.00.0The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. E G GRAY, V P WHITTAKERJ. Anat.196213901297Yes
190910481048.028.3928.4Cell signaling. H2O2, a necessary evil for cell signaling. Sue Goo RheeScience200616809515Yes
191010481048.044.1344.1A Social Neuroscience Perspective on Adolescent Risk-Taking. Laurence SteinbergDev Rev200818509515Yes
191110481048.065.1165.1Comments on 'KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease'. Konrad M AndrassyKidney Int.201323989362Yes
191220951047.551.2125.6Liver regeneration. G K Michalopoulos, M C DeFrancesScience19979082986No
191310471047.00.00.0Biological applications of ionophores. B C PressmanAnnu. Rev. Biochem.1976786156No
191410471047.043.4343.4Glutathione metabolism and its selective modification. A MeisterJ. Biol. Chem.19883053703No
191510471047.044.244.2Turnover of inositol phospholipids and signal transduction. Y NishizukaScience19846147898No
191610471047.056.2856.3Negative symptoms in schizophrenia. Definition and reliability. N C AndreasenArch. Gen. Psychiatry19827165477Yes
191710471047.037.1937.2Graphene transistors. Frank SchwierzNat Nanotechnol201020512128Yes
191820931046.5114.057.0Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. A Y Finlay, G K KhanClin. Exp. Dermatol.19948033378Yes
191910451045.047.1747.2Functional organization of central pathways regulating the cardiovascular system. R A DampneyPhysiol. Rev.19948171117No
192010451045.00.00.0Cognitive maps in rats and men. E C TOLMANPsychol Rev194818870876Yes
192110451045.00.00.0Phosphorus compounds in animal tissues; extraction and estimation of desoxypentose nucleic acid and of pentose nucleic acid. W C SCHNEIDERJ. Biol. Chem.194521005736Yes
192210441044.070.3870.4Conservation of resources. A new attempt at conceptualizing stress. S E HobfollAm Psychol19892648906No
192320881044.060.930.4Pharmacology and functions of metabotropic glutamate receptors. P J Conn, J P PinAnnu. Rev. Pharmacol. Toxicol.19979131252No
192410441044.027.7127.7Mechanisms of foxp3+ T regulatory cell-mediated suppression. Ethan M ShevachImmunity200919464986No
192520871043.564.0432.0Abdominal obesity and metabolic syndrome. Jean-Pierre Després, Isabelle LemieuxNature200617167477No
192610431043.038.9939.0Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. L BravoNutr. Rev.19989838798No
192720851042.560.4830.2A globally coherent fingerprint of climate change impacts across natural systems. Camille Parmesan, Gary YoheNature200312511946Yes
192810421042.022.0622.1Mobile elements: drivers of genome evolution. Haig H KazazianScience200415016989No
192920831041.571.6235.8CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. D G Higgins, P M SharpGene19883243435Yes
193010411041.00.00.0Some observations upon a new inhibitor of monoamine oxidase in brain tissue. J P JohnstonBiochem. Pharmacol.19685659776Yes
193110411041.028.6328.6Protein kinase C: structure, function, and regulation. A C NewtonJ. Biol. Chem.19957499357No
193210411041.033.633.6Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. D A DoughertyScience19968539615No
1933114511041.0334.8230.4New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. P Therasse, S G Arbuck, E A Eisenhauer, J Wanders, R S Kaplan, L Rubinstein, J Verweij, M Van Glabbeke, A T van Oosterom, M C Christian, S G GwytherJ. Natl. Cancer Inst.200010655437No
193410411041.020.5220.5The molecular motor toolbox for intracellular transport. Ronald D ValeCell200312600311No
193510411041.031.1531.1Interoception: the sense of the physiological condition of the body. A D CraigCurr. Opin. Neurobiol.200312965300No
193620801040.071.2735.6Transforming growth factor beta in tissue fibrosis. W A Border, N A NobleN. Engl. J. Med.19947935686No
193710401040.032.8132.8Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. R M SapolskyArch. Gen. Psychiatry200011015810No
193810401040.034.5934.6Bioactive microbial metabolites. János BérdyJ. Antibiot.200515813176No
193920791039.568.6634.3Early identification of refractory epilepsy. P Kwan, M J BrodieN. Engl. J. Med.200010660394Yes
194010391039.056.2856.3Sample size in qualitative research. M SandelowskiRes Nurs Health19957899572Yes
194120781039.075.7737.9What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. J Zhang, K F YuJAMA19989832001Yes
194210391039.022.1622.2CD95's deadly mission in the immune system. P H KrammerNature200011048730No
194331171039.072.4424.1The versatility and universality of calcium signalling. M J Berridge, P Lipp, M D BootmanNat. Rev. Mol. Cell Biol.200011413485No
194420761038.00.00.0Regulatory sequences involved in the promotion and termination of RNA transcription. M Rosenberg, D CourtAnnu. Rev. Genet.197994251No
194510381038.00.00.0Bias in analytic research. D L SackettJ Chronic Dis1979447779Yes
194620761038.079.439.7Glycine potentiates the NMDA response in cultured mouse brain neurons. J W Johnson, P AscherNature19872433595Yes
194710381038.054.4254.4The validity and practicality of sun-reactive skin types I through VI. T B FitzpatrickArch Dermatol19883377516Yes
194810381038.037.2637.3Infrared spectroscopy of proteins. Andreas BarthBiochim. Biophys. Acta200717692815No
194920751037.50.00.0Empirical predictions of protein conformation. P Y Chou, G D FasmanAnnu. Rev. Biochem.1978354496No
195051831036.6147.0129.4Development and testing of a general amber force field. Junmei Wang, Romain M Wolf, James W Caldwell, Peter A Kollman, David A CaseJ Comput Chem200415116359Yes
195120731036.558.4729.2Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. D A Brown, J K RoseCell19921531449Yes
195220731036.553.1526.6NF-kappaB: a key role in inflammatory diseases. P P Tak, G S FiresteinJ. Clin. Invest.200111134171No
195331091036.399.4433.1How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. R M Sapolsky, L M Romero, A U MunckEndocr. Rev.200010696570No
195431091036.3129.8143.3Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Helga Thorvaldsdóttir, James T Robinson, Jill P MesirovBrief. Bioinformatics201322517427Yes
195510361036.00.00.0Application of a Theory of Enzyme Specificity to Protein Synthesis. D E KoshlandProc. Natl. Acad. Sci. U.S.A.195816590179Yes
195610361036.056.4156.4Role of nrf2 in oxidative stress and toxicity. Qiang MaAnnu. Rev. Pharmacol. Toxicol.201323294312No
195720711035.595.8747.9The need to belong: desire for interpersonal attachments as a fundamental human motivation. R F Baumeister, M R LearyPsychol Bull19957777651No
195820711035.555.1627.6Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Jane E Visvader, Geoffrey J LindemanNat. Rev. Cancer200818784658No
195910351035.00.00.0A soluble protein characteristic of the nervous system. B W MooreBiochem. Biophys. Res. Commun.19654953930Yes
196010351035.030.5230.5Aspergillus fumigatus and aspergillosis. J P LatgéClin. Microbiol. Rev.199910194462No
196131031034.3134.6944.9Global estimates of the prevalence of diabetes for 2010 and 2030. J E Shaw, R A Sicree, P Z ZimmetDiabetes Res. Clin. Pract.201019896746Yes
196210341034.00.00.0Solute perturbation of protein fluorescence. The quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion. S S LehrerBiochemistry19715119250Yes
196310341034.037.9938.0Isolation and cultivation of Lyme disease spirochetes. A G BarbourYale J Biol Med19846393604Yes
196420671033.572.2936.1Mechanisms of salinity tolerance. Rana Munns, Mark TesterAnnu Rev Plant Biol200818444910No
196510331033.040.5740.6Ordinary magic. Resilience processes in development. A S MastenAm Psychol200111315249Yes
196610331033.00.00.0DITHIOTHREITOL, A NEW PROTECTIVE REAGENT FOR SH GROUPS. W W CLELANDBiochemistry196414192894Yes
196720661033.061.1530.6Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. M P Lutolf, J A HubbellNat. Biotechnol.200515637621No
196820651032.577.4938.7An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. S H Kim, J M ChungPain19921333581Yes
196910321032.031.6931.7Short-term synaptic plasticity. R S ZuckerAnnu. Rev. Neurosci.19892648947No
197010321032.061.4661.5A new international staging system for lung cancer. C F MountainChest19863514171No
197110321032.029.6929.7Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? Rui WangFASEB J.200212409322Yes
197210311031.038.3338.3Integrins. E RuoslahtiJ. Clin. Invest.19911985087No
197310311031.057.1257.1Cyclosporine. B D KahanN. Engl. J. Med.19892687689No
197420621031.071.6835.8Epidemiology of invasive candidiasis: a persistent public health problem. M A Pfaller, D J DiekemaClin. Microbiol. Rev.200717223626No
197510311031.00.00.0A new specific color reaction of hexuronic acids. Z DISCHEJ. Biol. Chem.194720281638Yes
197630931031.0147.2149.1featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Yang Liao, Gordon K Smyth, Wei ShiBioinformatics201424227677Yes
197710301030.00.00.0Calcium release from the sarcoplasmic reticulum. M EndoPhysiol. Rev.197713441Yes
197830901030.0106.535.5A rapid bootstrap algorithm for the RAxML Web servers. Alexandros Stamatakis, Paul Hoover, Jacques RougemontSyst. Biol.200818853362Yes
197920591029.583.1941.6Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. D S Bredt, S H SnyderProc. Natl. Acad. Sci. U.S.A.19901689048Yes
198010291029.028.2328.2Codon usage and tRNA content in unicellular and multicellular organisms. T IkemuraMol. Biol. Evol.19853916708No
198110291029.035.3735.4Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. P WillnerPsychopharmacology (Berl.)19979452163No
198210291029.031.6631.7Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. Y ShaiBiochim. Biophys. Acta199910590302No
198341121028.0109.5927.4Base-calling of automated sequencer traces using phred. I. Accuracy assessment. B Ewing, L Hillier, M C Wendl, P GreenGenome Res.19989521921Yes
198410281028.043.0643.1The polyvagal perspective. Stephen W PorgesBiol Psychol200717049418No
198510281028.030.2130.2Marine viruses--major players in the global ecosystem. Curtis A SuttleNat. Rev. Microbiol.200717853907No
198620551027.555.6227.8The RXR heterodimers and orphan receptors. D J Mangelsdorf, R M EvansCell19958521508No
198710271027.038.3638.4The many roles for fluorine in medicinal chemistry. William K HagmannJ. Med. Chem.200818570365Yes
198810271027.038.9939.0Stress signalling pathways that impair prefrontal cortex structure and function. Amy F T ArnstenNat. Rev. Neurosci.200919455173No
198910271027.046.246.2Large-scale brain networks and psychopathology: a unifying triple network model. Vinod MenonTrends Cogn. Sci. (Regul. Ed.)201121908230No
199010261026.034.1334.1A more meaningful scoring system for determining the severity of coronary heart disease. G G GensiniAm. J. Cardiol.19836823874Yes
199120511025.50.00.0A general method for isolation of high molecular weight DNA from eukaryotes. N Blin, D W StaffordNucleic Acids Res.1976987581Yes
199210251025.00.00.0The ultrastructural basis of capillary permeability studied with peroxidase as a tracer. M J KarnovskyJ. Cell Biol.19676061717Yes
199310251025.023.0823.1The significance of responses of the genome to challenge. B McClintockScience198415739260No
199420491024.561.9931.0The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Daniel J Drucker, Michael A NauckLancet200617098089No
199520491024.573.3136.7Protective and pathogenic functions of macrophage subsets. Peter J Murray, Thomas A WynnNat. Rev. Immunol.201121997792No
199610241024.020.4520.4c-Myc target genes involved in cell growth, apoptosis, and metabolism. C V DangMol. Cell. Biol.19999858526No
199710241024.030.4730.5Tobacco smoke carcinogens and lung cancer. S S HechtJ. Natl. Cancer Inst.199910413421No
199810241024.025.1325.1The stem-cell niche as an entity of action. David T ScaddenNature200616810242No
199920481024.070.8435.4CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. Mattias Jakobsson, Noah A RosenbergBioinformatics200717485429Yes
200010231023.032.2632.3Speculations on the functions of the major heat shock and glucose-regulated proteins. H R PelhamCell19862944601Yes
200110231023.039.2439.2Osteoblast adhesion on biomaterials. K AnselmeBiomaterials200010711964No
200220461023.041.5120.8DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Christopher J Bakkenist, Michael B KastanNature200312556884Yes
200320441022.059.2229.6Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. M Zuker, P StieglerNucleic Acids Res.19816163133Yes
200430651021.795.1531.7The metabolic syndrome. Robert H Eckel, Scott M Grundy, Paul Z ZimmetLancet200515836891No
200520421021.056.4828.2Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. M E Greenberg, E B ZiffNature19846090941Yes
200610211021.029.8229.8Two pathogenetic types of endometrial carcinoma. J V BokhmanGynecol. Oncol.19836822361Yes
200710211021.025.2725.3Dimerization of cell surface receptors in signal transduction. C H HeldinCell19957834741No
200830631021.081.2527.1Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Witold Filipowicz, Suvendra N Bhattacharyya, Nahum SonenbergNat. Rev. Genet.200818197166No
200920411020.553.4326.7Mitochondrial control of cell death. G Kroemer, J C ReedNat. Med.200010802706No
201010201020.00.00.0CHEMOAFFINITY IN THE ORDERLY GROWTH OF NERVE FIBER PATTERNS AND CONNECTIONS. R W SPERRYProc. Natl. Acad. Sci. U.S.A.196314077501Yes
201110201020.031.5531.6Microbial influences in inflammatory bowel diseases. R Balfour SartorGastroenterology200818242222No
201220371018.551.6125.8Cellular senescence: when bad things happen to good cells. Judith Campisi, Fabrizio d'Adda di FagagnaNat. Rev. Mol. Cell Biol.200717667954No
201310181018.00.00.0Hippocampal electrical activity and voluntary movement in the rat. C H VanderwolfElectroencephalogr Clin Neurophysiol19694183562Yes
201410181018.049.0249.0Presidential address, 1980. Surprise!...Surprise? E DonchinPsychophysiology19817280146Yes
201510181018.033.233.2Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. Arnold I CaplanJ. Cell. Physiol.200717620285No
201630531017.799.733.2Atomic force microscope. Binnig, Quate, GerberPhys. Rev. Lett.198610033323Yes
201710171017.00.00.0Carbonic anhydrase: chemistry, physiology, and inhibition. T H MarenPhysiol. Rev.19674964060No
201810171017.00.00.0Anterior acromioplasty for the chronic impingement syndrome in the shoulder: a preliminary report. C S NeerJ Bone Joint Surg Am19725054450Yes
201910161016.052.7552.8Reliability and factor analysis of the Epworth Sleepiness Scale. M W JohnsSleep19921519015Yes
202010161016.00.00.0The biologic clock: the mitochondria? D HarmanJ Am Geriatr Soc19725016631Yes
202110161016.048.2448.2Colorimetric determination of phospholipids with ammonium ferrothiocyanate. J C StewartAnal. Biochem.19806892980Yes
202220321016.046.1623.1Gene silencing in cancer in association with promoter hypermethylation. James G Herman, Stephen B BaylinN. Engl. J. Med.200314627790No
202310161016.030.9430.9The human orbitofrontal cortex: linking reward to hedonic experience. Morten L KringelbachNat. Rev. Neurosci.200516136173No
202420301015.067.6633.8Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. C Auffray, F RougeonEur. J. Biochem.19806772444Yes
202520301015.057.4928.7Integrins and signal transduction pathways: the road taken. E A Clark, J S BruggeScience19957716514No
202620301015.068.8834.4Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. F D Lublin, S C ReingoldNeurology19968780061Yes
202710151015.037.5437.5Chronic disease management: what will it take to improve care for chronic illness? E H WagnerEff Clin Pract199810345255No
202810151015.040.2640.3The law of attrition. Gunther EysenbachJ. Med. Internet Res.200515829473Yes
202910151015.030.8830.9Pathogen recognition and inflammatory signaling in innate immune defenses. Trine H MogensenClin. Microbiol. Rev.200919366914No
203060881014.7179.6229.9A default mode of brain function. M E Raichle, A M MacLeod, A Z Snyder, W J Powers, D A Gusnard, G L ShulmanProc. Natl. Acad. Sci. U.S.A.200111209064Yes
203120291014.576.938.5Estimating wealth effects without expenditure data--or tears: an application to educational enrollments in states of India. D Filmer, L H PritchettDemography200111227840Yes
203220291014.591.7845.9Microenvironmental regulation of tumor progression and metastasis. Daniela F Quail, Johanna A JoyceNat. Med.201324202395No
203391241013.8373.7241.5The 1982 revised criteria for the classification of systemic lupus erythematosus. E M Tan, A S Cohen, J F Fries, A T Masi, D J McShane, N F Rothfield, J G Schaller, N Talal, R J WinchesterArthritis Rheum.19827138600Yes
203420271013.556.0528.0The DNA damage response: making it safe to play with knives. Alberto Ciccia, Stephen J ElledgeMol. Cell201020965415No
203510131013.032.1432.1The importance of the ratio of omega-6/omega-3 essential fatty acids. A P SimopoulosBiomed. Pharmacother.200212442909No
203620261013.084.9142.5Saliency, switching, attention and control: a network model of insula function. Vinod Menon, Lucina Q UddinBrain Struct Funct201020512370No
203730371012.3100.6933.6Regularization Paths for Generalized Linear Models via Coordinate Descent. Jerome Friedman, Trevor Hastie, Rob TibshiraniJ Stat Softw201020808728Yes
203840491012.2148.0537.0Reversible middle cerebral artery occlusion without craniectomy in rats. E Z Longa, P R Weinstein, S Carlson, R CumminsStroke19892643202Yes
203910121012.039.2739.3Biological basis of the behavior of sick animals. B L HartNeurosci Biobehav Rev19883050629No
204010121012.040.6940.7Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. A E PeggCancer Res.19883123052No
204110121012.00.00.0A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces. M G BUONOCOREJ. Dent. Res.195513271655Yes
204230351011.70.00.0The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. J T DODGE, C MITCHELL, D J HANAHANArch. Biochem. Biophys.196314028302Yes
204350571011.4185.6337.1Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Ronald C Kessler, Wai Tat Chiu, Olga Demler, Kathleen R Merikangas, Ellen E WaltersArch. Gen. Psychiatry200515939839Yes
204420221011.061.8230.9Rising incidence of hepatocellular carcinoma in the United States. H B El-Serag, A C MasonN. Engl. J. Med.199910072408Yes
204520211010.541.8520.9Live or let die: the cell's response to p53. Karen H Vousden, Xin LuNat. Rev. Cancer200212154352No
204620211010.547.2823.6Regulated portals of entry into the cell. Sean D Conner, Sandra L SchmidNature200312621426No
204740421010.5166.0241.5A brief measure for assessing generalized anxiety disorder: the GAD-7. Robert L Spitzer, Kurt Kroenke, Janet B W Williams, Bernd LöweArch. Intern. Med.200616717171Yes
204810101010.035.2435.2Rheumatoid arthritis. Pathophysiology and implications for therapy. E D HarrisN. Engl. J. Med.19902271017No
204920201010.060.5430.3The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. Clay B Holroyd, Michael G H ColesPsychol Rev200212374324Yes
205010101010.030.530.5The hydrogen bond in the solid state. Thomas SteinerAngew. Chem. Int. Ed. Engl.200212491444Yes
205110091009.039.4339.4Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. A A GraceNeuroscience19911676137No
205210091009.040.9641.0Equipoise and the ethics of clinical research. B FreedmanN. Engl. J. Med.19873600702Yes
205310091009.018.0318.0Themes and variations on ubiquitylation. A M WeissmanNat. Rev. Mol. Cell Biol.200111265246No
205430261008.7139.5446.5CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Teresa C Horan, Mary Andrus, Margaret A DudeckAm J Infect Control200818538699No
205520171008.554.2127.1Disruption of epithelial cell-matrix interactions induces apoptosis. S M Frisch, H FrancisJ. Cell Biol.19948106557Yes
205660491008.2200.2533.4Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. Roy G Brower, Michael A Matthay, Alan Morris, David Schoenfeld, B Taylor Thompson, Arthur WheelerN. Engl. J. Med.200010793162Yes
205710081008.039.5239.5Pathogenetic mechanisms of septic shock. J E ParrilloN. Engl. J. Med.19938479467No
205810081008.029.9429.9Papillomavirus infections--a major cause of human cancers. H zur HausenBiochim. Biophys. Acta19968876633No
2059110881008.0378.9634.5The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. Aram V Chobanian, George L Bakris, Henry R Black, William C Cushman, Lee A Green, Joseph L Izzo, Daniel W Jones, Barry J Materson, Suzanne Oparil, Jackson T Wright, Edward J RoccellaJAMA200312748199No
206010071007.00.00.0Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. K S McCullyAm. J. Pathol.19695792556Yes
206110071007.00.00.0On the law of effect. R J HerrnsteinJ Exp Anal Behav197016811440Yes
206250321006.4151.2930.3Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Sarah Lewington, Robert Clarke, Nawab Qizilbash, Richard Peto, Rory CollinsLancet200212493255Yes
206310061006.026.6726.7Double identity for proteins of the Bcl-2 family. J C ReedNature19979194558No
206430171005.7131.2343.7A new method for off-line removal of ocular artifact. G Gratton, M G Coles, E DonchinElectroencephalogr Clin Neurophysiol19836187540Yes
206520111005.589.6844.8Universal chemical assay for the detection and determination of siderophores. B Schwyn, J B NeilandsAnal. Biochem.19872952030Yes
206620111005.574.1537.1Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins. D Marion, K WüthrichBiochem. Biophys. Res. Commun.19836307308Yes
206720111005.561.230.6Neuronal plasticity: increasing the gain in pain. C J Woolf, M W SalterScience200010846153No
206830151005.00.00.0A highly sensitive adenylate cyclase assay. Y Salomon, C Londos, M RodbellAnal. Biochem.19744827395Yes
206910051005.00.00.0Codon--anticodon pairing: the wobble hypothesis. F H CrickJ. Mol. Biol.19665969078Yes
207020101005.069.0834.5Bronchopulmonary dysplasia. A H Jobe, E BancalariAm. J. Respir. Crit. Care Med.200111401896No
207110051005.034.1934.2Polycystic ovary syndrome. David A EhrmannN. Engl. J. Med.200515788499No
207270341004.9156.6322.4Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Rafael A Irizarry, Bridget Hobbs, Francois Collin, Yasmin D Beazer-Barclay, Kristen J Antonellis, Uwe Scherf, Terence P SpeedBiostatistics200312925520Yes
207310041004.071.0271.0The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. G A IlizarovClin. Orthop. Relat. Res.19892910611Yes
207430101003.3124.3341.4Factor structure of the Barratt impulsiveness scale. J H Patton, M S Stanford, E S BarrattJ Clin Psychol19958778124Yes
207510031003.028.6128.6Reactive oxygen radicals in signaling and damage in the ischemic brain. P H ChanJ. Cereb. Blood Flow Metab.200111149664No
207610031003.028.728.7Upconversion and anti-Stokes processes with f and d ions in solids. François AuzelChem. Rev.200414719973Yes
207720061003.066.9233.5Molecular replacement with MOLREP. Alexei Vagin, Alexei TeplyakovActa Crystallogr. D Biol. Crystallogr.201020057045Yes
207810021002.046.8946.9Serum albumin. T PetersAdv. Protein Chem.19853904348No
207920041002.083.8741.9Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. M M Bradley, P J LangJ Behav Ther Exp Psychiatry19947962581Yes
208020041002.083.942.0Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. J W Vlaeyen, S J LintonPain200010781906No
208110021002.031.7731.8The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. T SzkudelskiPhysiol Res200111829314No
208210011001.024.3224.3Caspase structure, proteolytic substrates, and function during apoptotic cell death. D W NicholsonCell Death Differ.199910578171No
208320011000.5112.3856.2Natural products as sources of new drugs over the 30 years from 1981 to 2010. David J Newman, Gordon M CraggJ. Nat. Prod.201222316239No
208410001000.031.7131.7The aryl hydrocarbon receptor complex. O HankinsonAnnu. Rev. Pharmacol. Toxicol.19957598497No
208530001000.0104.0634.7I-TASSER: a unified platform for automated protein structure and function prediction. Ambrish Roy, Alper Kucukural, Yang ZhangNat Protoc201020360767Yes
20861999999.561.3830.7Macrophage diversity enhances tumor progression and metastasis. Bin-Zhi Qian, Jeffrey W PollardCell201020371344No
2087999999.034.034.0Type I diabetes mellitus. A chronic autoimmune disease. G S EisenbarthN. Engl. J. Med.19863517648No
20881998999.050.3625.2The pathophysiology of mitochondrial cell death. Douglas R Green, Guido KroemerScience200415286356No
20891997998.50.00.0Mutants of Escherichia coli requiring methionine or vitamin B12. B D DAVIS, E S MINGIOLIJ. Bacteriol.195015436457Yes
20901996998.065.732.9What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? K C Berridge, T E RobinsonBrain Res. Brain Res. Rev.19989858756No
20913992998.091.2522.8Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. D D Sarbassov, David A Guertin, Siraj M Ali, David M SabatiniScience200515718470Yes
20921996998.059.3829.7Powering the planet: chemical challenges in solar energy utilization. Nathan S Lewis, Daniel G NoceraProc. Natl. Acad. Sci. U.S.A.200617043226Yes
2093997997.033.3133.3Cellular oncogenes and retroviruses. J M BishopAnnu. Rev. Biochem.19836351725No
2094997997.00.00.0The etiology of chondromalacia patellae. R E OUTERBRIDGEJ Bone Joint Surg Br196114038135Yes
2095997997.027.5627.6Fast and robust fixed-point algorithms for independent component analysis. A HyvärinenIEEE Trans Neural Netw199918252563Yes
20963988997.0210.9952.7Bayesian phylogenetics with BEAUti and the BEAST 1.7. Alexei J Drummond, Marc A Suchard, Dong Xie, Andrew RambautMol. Biol. Evol.201222367748Yes
20971993996.553.9927.0Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. M Fried, D M CrothersNucleic Acids Res.19816275366Yes
2098996996.00.00.0Cerebral blood flow and oxygen consumption in man. N A LASSENPhysiol. Rev.195913645234Yes
2099996996.033.6833.7The sympathetic control of blood pressure. Patrice G GuyenetNat. Rev. Neurosci.200616760914No
2100995995.040.9741.0Cross-dehydrogenative coupling (CDC): exploring C-C bond formations beyond functional group transformations. Chao-Jun LiAcc. Chem. Res.200919220064Yes
21011990995.056.328.1Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Kornelia Polyak, Robert A WeinbergNat. Rev. Cancer200919262571No
2102994994.031.5331.5VLA proteins in the integrin family: structures, functions, and their role on leukocytes. M E HemlerAnnu. Rev. Immunol.19902188667No
2103994994.036.236.2Treatment of infections associated with surgical implants. Rabih O DarouicheN. Engl. J. Med.200415070792No
21041987993.538.6719.3The DNA damage response: putting checkpoints in perspective. B B Zhou, S J ElledgeNature200011100718No
2105993993.00.00.0Atherogenesis: a postprandial phenomenon. D B ZilversmitCirculation1979222498Yes
2106993993.051.0451.0Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. A H ConneyCancer Res.19826814745No
2107992992.038.1238.1Classification of chronic viral hepatitis: a need for reassessment. P J ScheuerJ. Hepatol.19911808228No
2108992992.00.00.0Extraordinary sex ratios. A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology. W D HamiltonScience19676021675Yes
2109992992.044.5244.5The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. E J KhantzianHarv Rev Psychiatry19979385000No
21101983991.559.0629.5The free radical theory of aging matures. K B Beckman, B N AmesPhysiol. Rev.19989562038No
2111991991.025.7925.8S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. R DonatoInt. J. Biochem. Cell Biol.200111390274No
2112991991.020.1320.1microRNAs: tiny regulators with great potential. V AmbrosCell200111779458No
21133963990.8105.4726.4Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. Eugenia E Calle, Carmen Rodriguez, Kimberly Walker-Thurmond, Michael J ThunN. Engl. J. Med.200312711737Yes
21141981990.551.1125.6Self-assembly at all scales. George M Whitesides, Bartosz GrzybowskiScience200211923529Yes
2115990990.00.00.0The origin of the genetic code. F H CrickJ. Mol. Biol.19684887876Yes
2116990990.066.3366.3Subjective well-being. E DienerPsychol Bull19846399758No
2117990990.042.4742.5Glycosphingolipids in cellular interaction, differentiation, and oncogenesis. S HakomoriAnnu. Rev. Biochem.19817023369No
2118990990.030.1730.2Rapid evolution of a protein in vitro by DNA shuffling. W P StemmerNature19948047147Yes
2119990990.035.8635.9Invasive aspergillosis. D W DenningClin. Infect. Dis.19989564455No
21201979989.547.2423.6ERBB receptors and cancer: the complexity of targeted inhibitors. Nancy E Hynes, Heidi A LaneNat. Rev. Cancer200515864276No
21211979989.571.7435.9A perspective on cancer cell metastasis. Christine L Chaffer, Robert A WeinbergScience201121436443No
21223956989.00.00.0Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. D W Cleveland, S G Fischer, M W Kirschner, U K LaemmliJ. Biol. Chem.1977320200Yes
2123989989.033.6533.6Cell and environment interactions in tumor microregions: the multicell spheroid model. R M SutherlandScience19882451290Yes
2124989989.032.8132.8Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. U MitzdorfPhysiol. Rev.19853880898No
2125989989.033.3833.4Diagnosis of osteoporosis and assessment of fracture risk. John A KanisLancet200212057569No
2126989989.036.1536.1Semiempirical hybrid density functional with perturbative second-order correlation. Stefan GrimmeJ Chem Phys200616438568Yes
21271977988.545.2222.6Molecular chaperones in the cytosol: from nascent chain to folded protein. F Ulrich Hartl, Manajit Hayer-HartlScience200211884745No
21285929988.2126.1121.0Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. S M Elbashir, J Harborth, W Lendeckel, A Yalcin, K Weber, T TuschlNature200111373684Yes
2129987987.034.3334.3Varieties of impulsivity. J L EvendenPsychopharmacology (Berl.)199910550486No
21301974987.092.4846.2The Oswestry Disability Index. J C Fairbank, P B PynsentSpine200011074683No
2131987987.00.00.0Modality and topographic properties of single neurons of cat's somatic sensory cortex. V B MOUNTCASTLEJ. Neurophysiol.195713439410Yes
2132987987.021.9321.9IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Yong-Jun LiuAnnu. Rev. Immunol.200515771572No
21332958986.00.00.0Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Garnier, D J Osguthorpe, B RobsonJ. Mol. Biol.1978642007Yes
21341972986.049.9725.0Adaptive protein evolution at the Adh locus in Drosophila. J H McDonald, M KreitmanNature19911904993Yes
2135986986.00.00.0The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. A G PearseJ. Histochem. Cytochem.19694143745No
2136986986.022.2622.3Lipid rafts: elusive or illusive? Sean MunroCell200314622593No
2137986986.025.0725.1Long-term potentiation and memory. M A LynchPhysiol. Rev.200414715912No
2138985985.019.2619.3Cancer susceptibility and the functions of BRCA1 and BRCA2. Ashok R VenkitaramanCell200211832208No
2139985985.00.00.0Diversity in tropical rain forests and coral reefs. J H ConnellScience197817840770Yes
21404922984.4251.950.4UCHIME improves sensitivity and speed of chimera detection. Robert C Edgar, Brian J Haas, Jose C Clemente, Christopher Quince, Rob KnightBioinformatics201121700674Yes
21412953984.3182.2360.7Risk factors for falls among elderly persons living in the community. M E Tinetti, M Speechley, S F GinterN. Engl. J. Med.19883205267Yes
2142984984.020.0820.1Kinesin and dynein superfamily proteins and the mechanism of organelle transport. N HirokawaScience19989438838No
2143983983.028.8928.9Clinical features of metastatic bone disease and risk of skeletal morbidity. Robert E ColemanClin. Cancer Res.200617062708No
21443931982.896.1824.0Interleukin-10 and the interleukin-10 receptor. K W Moore, R de Waal Malefyt, R L Coffman, A O'GarraAnnu. Rev. Immunol.200111244051No
21453931982.8179.1644.8Prevalence and trends in obesity among US adults, 1999-2008. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Lester R CurtinJAMA201020071471Yes
21461965982.571.8435.9Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. James J Gross, Oliver P JohnJ Pers Soc Psychol200312916575Yes
2147982982.00.00.0Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase. H S PenefskyJ. Biol. Chem.197716006Yes
21481964982.047.2423.6CpG islands in vertebrate genomes. M Gardiner-Garden, M FrommerJ. Mol. Biol.19873656447Yes
2149982982.028.4428.4Proinflammatory cytokines. C A DinarelloChest200010936147No
2150981981.038.8438.8An application of prefrontal cortex function theory to cognitive aging. R L WestPsychol Bull19968831298No
21511962981.040.4620.2The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. T Maehama, J E DixonJ. Biol. Chem.19989593664Yes
21521962981.063.5631.8The gut microbiota shapes intestinal immune responses during health and disease. June L Round, Sarkis K MazmanianNat. Rev. Immunol.200919343057No
21532941980.382.5727.5Global and societal implications of the diabetes epidemic. P Zimmet, K G Alberti, J ShawNature200111742409No
21542940980.0183.1461.0In search of how people change. Applications to addictive behaviors. J O Prochaska, C C DiClemente, J C NorcrossAm Psychol19921329589Yes
2155980980.047.7247.7Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). G G GlennerN. Engl. J. Med.19806154243No
21561959979.50.00.0Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. J E Sulston, H R HorvitzDev. Biol.1977838129Yes
21575876979.3258.1343.0TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L SalzbergGenome Biol.201323618408Yes
21581958979.00.00.0Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. D B Dill, D L CostillJ Appl Physiol19744850854Yes
2159979979.042.5342.5Inhibition and facilitation of nucleic acid amplification. I G WilsonAppl. Environ. Microbiol.19979327537No
2160979979.025.3525.4Molecular physiology of low-voltage-activated t-type calcium channels. Edward Perez-ReyesPhysiol. Rev.200312506128No
2161979979.030.2230.2Plasmonics: merging photonics and electronics at nanoscale dimensions. Ekmel OzbayScience200616410515Yes
21621956978.065.7932.9Production of single-stranded plasmid DNA. J Vieira, J MessingMeth. Enzymol.19873323803Yes
2163978978.042.4142.4The World Oral Health Report 2003: continuous improvement of oral health in the 21st century--the approach of the WHO Global Oral Health Programme. Poul Erik PetersenCommunity Dent Oral Epidemiol200315015736Yes
2164978978.030.0230.0Pain and emotion interactions in subregions of the cingulate gyrus. Brent A VogtNat. Rev. Neurosci.200515995724No
2165978978.00.00.0The estimation of phosphorus. R J AllenBiochem. J.194016747230Yes
2166978978.032.1632.2Plant productivity and environment. J S BoyerScience198217808529Yes
2167978978.00.00.0CRYSTALLINE SOYBEAN TRYPSIN INHIBITOR : II. GENERAL PROPERTIES. M KunitzJ. Gen. Physiol.194719873496Yes
21681955977.579.5239.8Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J E Hixson, D T VernierJ. Lipid Res.19902341813Yes
21693910977.5103.6825.9SCOP: a structural classification of proteins database for the investigation of sequences and structures. A G Murzin, S E Brenner, T Hubbard, C ChothiaJ. Mol. Biol.19957723011Yes
21701953976.50.00.0Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Altman, G D DasJ. Comp. Neurol.19655861717Yes
2171976976.027.3627.4The 'effective number of codons' used in a gene. F WrightGene19902110097Yes
2172976976.033.6333.6The molecular genetics of cancer. J M BishopScience19873541204No
21733904976.0115.5728.9Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. H Nielsen, J Engelbrecht, S Brunak, G von HeijneProtein Eng.19979051728Yes
2174976976.028.3828.4Primate anterior cingulate cortex: where motor control, drive and cognition interface. T PausNat. Rev. Neurosci.200111389475No
21751951975.50.00.0Assay of proteins in the presence of interfering materials. A Bensadoun, D WeinsteinAnal. Biochem.19761259145Yes
21761950975.00.00.0Prediction of protein conformation. P Y Chou, G D FasmanBiochemistry19744358940Yes
2177975975.00.00.0The organization of proteins in the human red blood cell membrane. A review. T L SteckJ. Cell Biol.19744600883No
2178975975.00.00.0Defective repair replication of DNA in xeroderma pigmentosum. J E CleaverNature19685655953Yes
2179975975.083.1183.1The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. F DenisSpine19836670016Yes
2180975975.020.5620.6A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development. Xuemei ChenScience200412893888Yes
21812924974.770.323.4Calcium signalling: dynamics, homeostasis and remodelling. Michael J Berridge, Martin D Bootman, H Llewelyn RoderickNat. Rev. Mol. Cell Biol.200312838335No
2182974974.00.00.0Superoxide dismutases. I FridovichAnnu. Rev. Biochem.19751094908No
2183974974.082.2282.2Impingement lesions. C S NeerClin. Orthop. Relat. Res.19836825348Yes
2184974974.022.7822.8Morphogenetic roles of classic cadherins. M TakeichiCurr. Opin. Cell Biol.19958573335No
2185974974.026.026.0Production of recombinant protein therapeutics in cultivated mammalian cells. Florian M WurmNat. Biotechnol.200415529164No
2186974974.030.3530.4Q-ball imaging. David S TuchMagn Reson Med200415562495Yes
21871947973.564.6432.3Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. E Y Chen, P H SeeburgDNA19853996185Yes
21881947973.562.4431.2Imaging cognition II: An empirical review of 275 PET and fMRI studies. R Cabeza, L NybergJ Cogn Neurosci200010769304No
2189973973.041.8341.8Deliberate practice and the acquisition and maintenance of expert performance in medicine and related domains. K Anders EricssonAcad Med200415383395No
2190973973.022.3322.3Maintenance of C. elegans. Theresa StiernagleWormBook200618050451No
2191973973.042.3342.3Functional and effective connectivity: a review. Karl J FristonBrain Connect201122432952No
2192972972.00.00.0Drugs which inhibit prostaglandin biosynthesis. R J FlowerPharmacol. Rev.19744208101Yes
2193972972.00.00.0Computerized transverse axial scanning (tomography). 1. Description of system. G N HounsfieldBr J Radiol19734757352Yes
2194972972.049.7749.8Cardiac valve surgery--the "French correction". A CarpentierJ. Thorac. Cardiovasc. Surg.19836887954Yes
2195972972.024.4124.4Transcriptional control of adipocyte formation. Stephen R FarmerCell Metab.200617011499No
21961943971.50.00.0Maximum utilization of the life table method in analyzing survival. S J CUTLER, F EDERERJ Chronic Dis195813598782Yes
2197971971.045.1145.1Lyme disease. A C SteereN. Engl. J. Med.19892668764No
2198971971.00.00.0Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. J W OlneyScience19695778021Yes
21991942971.069.534.8Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. M J Casadaban, S N CohenJ. Mol. Biol.19806997493Yes
2200971971.026.6626.7Allelic discrimination using fluorogenic probes and the 5' nuclease assay. K J LivakGenet. Anal.199910084106Yes
2201971971.026.4626.5Liver fibrosis -- from bench to bedside. Scott L FriedmanJ. Hepatol.200312591185No
22022913971.072.3624.1OrthoMCL: identification of ortholog groups for eukaryotic genomes. Li Li, Christian J Stoeckert, David S RoosGenome Res.200312952885Yes
2203970970.022.9823.0STATs: signal transducers and activators of transcription. J N IhleCell19968608586No
2204970970.022.2822.3Cytokines induce the development of functionally heterogeneous T helper cell subsets. A O'GarraImmunity19989529145No
2205970970.026.226.2Mitochondrial transport of cations: channels, exchangers, and permeability transition. P BernardiPhysiol. Rev.199910508231No
2206970970.023.5223.5The roles of intracellular protein-degradation pathways in neurodegeneration. David C RubinszteinNature200617051204No
2207969969.045.8545.9The life and times of the Enterococcus. B E MurrayClin. Microbiol. Rev.19902404568No
2208969969.035.7235.7Early signals in the mitogenic response. E RozengurtScience19863018928No
22091937968.547.9124.0Functions of lipid rafts in biological membranes. D A Brown, E LondonAnnu. Rev. Cell Dev. Biol.19989891780No
22102905968.367.7322.6Cellular survival: a play in three Akts. S R Datta, A Brunet, M E GreenbergGenes Dev.199910579998No
2211968968.033.8933.9Tumor necrosis factor (TNF). L J OldScience19852413547Yes
22121936968.053.2726.6Raster3D Version 2.0. A program for photorealistic molecular graphics. E A Merritt, M E MurphyActa Crystallogr. D Biol. Crystallogr.199415299354Yes
22131935967.553.2726.6Peroxisome proliferator-activated receptors: nuclear control of metabolism. B Desvergne, W WahliEndocr. Rev.199910529898No
22142902967.3133.3944.5Vascular endothelial cells synthesize nitric oxide from L-arginine. R M Palmer, D S Ashton, S MoncadaNature19883131684Yes
22151934967.064.7132.4Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. M D Pierschbacher, E RuoslahtiNature19846325925Yes
2216967967.044.8744.9Linkage map of Escherichia coli K-12, edition 7. B J BachmannMicrobiol. Rev.19836348505No
22171934967.064.9332.5A review of central 5-HT receptors and their function. N M Barnes, T SharpNeuropharmacology199910462127No
2218967967.031.2231.2The cancer stem cell: premises, promises and challenges. Hans CleversNat. Med.201121386835No
22191934967.0101.1450.6Regulation of microRNA biogenesis. Minju Ha, V Narry KimNat. Rev. Mol. Cell Biol.201425027649No
2220966966.053.0953.1The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. E J KhantzianAm J Psychiatry19853904487No
2221966966.027.3427.3Matrix proteoglycans: from molecular design to cellular function. R V IozzoAnnu. Rev. Biochem.19989759499No
22221932966.069.1534.6The cortical organization of speech processing. Gregory Hickok, David PoeppelNat. Rev. Neurosci.200717431404No
2223965965.00.00.0An enzymic method for the trace iodination of immunoglobulins and other proteins. J J MarchalonisBiochem. J.19694185494Yes
2224965965.035.2535.2Diversity of group types, regulation, and function of phospholipase A2. E A DennisJ. Biol. Chem.19948175726No
2225965965.032.5332.5Low density lipoprotein oxidation and its pathobiological significance. D SteinbergJ. Biol. Chem.19979261091No
22262895965.072.1524.1Multidrug resistance in cancer: role of ATP-dependent transporters. Michael M Gottesman, Tito Fojo, Susan E BatesNat. Rev. Cancer200211902585No
2227965965.041.1341.1The global impact of pre-eclampsia and eclampsia. Lelia DuleySemin. Perinatol.200919464502No
22281930965.071.1835.6Astrocytes: biology and pathology. Michael V Sofroniew, Harry V VintersActa Neuropathol.201020012068No
2229964964.032.7832.8Phylogenies from molecular sequences: inference and reliability. J FelsensteinAnnu. Rev. Genet.19883071258No
2230964964.025.8425.8Diarylethenes for Memories and Switches. Masahiro IrieChem. Rev.200011777416Yes
2231964964.025.4425.4Pedigree disequilibrium tests for multilocus haplotypes. Frank DudbridgeGenet. Epidemiol.200312916020Yes
2232964964.028.6828.7Overview of general physiologic features and functions of vitamin D. Hector F DeLucaAm. J. Clin. Nutr.200415585789No
2233964964.037.3737.4Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Thomas GrobnerNephrol. Dial. Transplant.200616431890Yes
2234964964.031.4131.4Atopic dermatitis. Thomas BieberN. Engl. J. Med.200818385500Yes
22357711963.9227.1128.4Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. N Tzourio-Mazoyer, B Landeau, D Papathanassiou, F Crivello, O Etard, N Delcroix, B Mazoyer, M JoliotNeuroimage200211771995Yes
22361927963.5129.7964.9Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. S F Dworkin, L LeRescheJ Craniomandib Disord19921298767No
2237963963.00.00.0Metabolic stability and epigenesis in randomly constructed genetic nets. S A KauffmanJ. Theor. Biol.19695803332Yes
22381925962.50.00.0Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. L F Berkman, S L SymeAm. J. Epidemiol.1979425958Yes
22392887962.379.2426.4Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. Christian W Tornøe, Caspar Christensen, Morten MeldalJ. Org. Chem.200211975567Yes
2240962962.033.2133.2The induction of pain: an integrative review. M J MillanProg. Neurobiol.19999987804No
22411924962.076.2738.1The pathogenesis of rheumatoid arthritis. Iain B McInnes, Georg SchettN. Engl. J. Med.201122150039No
2242962962.043.4943.5Asthma phenotypes: the evolution from clinical to molecular approaches. Sally E WenzelNat. Med.201222561835No
2243961961.00.00.0The measurement of psychological androgyny. S L BemJ Consult Clin Psychol19744823550Yes
2244961961.028.1628.2The neuropathology of schizophrenia. A critical review of the data and their interpretation. P J HarrisonBrain199910219775No
22454804960.896.3719.3Crystal structure of the nucleosome core particle at 2.8 A resolution. K Luger, A W Mäder, R K Richmond, D F Sargent, T J RichmondNature19979305837Yes
22461921960.50.00.0The effect of sodium ions on the electrical activity of giant axon of the squid. A L HODGKIN, B KATZJ. Physiol. (Lond.)194918128147Yes
2247960960.030.3130.3Psychological and neural mechanisms of the affective dimension of pain. D D PriceScience200010846154No
22482880960.068.622.9Toll-like receptors: critical proteins linking innate and acquired immunity. S Akira, K Takeda, T KaishoNat. Immunol.200111477402No
22494798959.6234.3446.9Evidence based medicine: what it is and what it isn't. D L Sackett, W M Rosenberg, J A Gray, R B Haynes, W S RichardsonBMJ19968555924No
22501919959.556.4528.2Statistical tests of neutrality of mutations. Y X Fu, W H LiGenetics19938454210Yes
2251959959.018.4518.4Stem cells: units of development, units of regeneration, and units in evolution. I L WeissmanCell200010647940No
22521918959.060.0330.0Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Barry J Everitt, Trevor W RobbinsNat. Neurosci.200516251991No
22532877959.0176.458.8HISAT: a fast spliced aligner with low memory requirements. Daehwan Kim, Ben Langmead, Steven L SalzbergNat. Methods201525751142Yes
2254958958.040.6140.6SPSS and SAS programs for determining the number of components using parallel analysis and velicer's MAP test. B P O'ConnorBehav Res Methods Instrum Comput200011029811Yes
2255958958.00.00.0ANTIGEN-ANTIBODY CROSSED ELECTROPHORESIS. C B LAURELLAnal. Biochem.196514302464Yes
22561915957.567.7333.9Genome regulation by long noncoding RNAs. John L Rinn, Howard Y ChangAnnu. Rev. Biochem.201222663078No
2257957957.025.0625.1Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach. Michael J SandersonMol. Biol. Evol.200211752195Yes
2258957957.031.5131.5Synergy, antagonism, and what the chequerboard puts between them. F C OddsJ. Antimicrob. Chemother.200312805255No
2259957957.026.5126.5Pathways of oxidative damage. James A ImlayAnnu. Rev. Microbiol.200314527285No
2260957957.025.7525.8The impact of next-generation sequencing technology on genetics. Elaine R MardisTrends Genet.200818262675No
2261957957.023.5323.5Neuroligins and neurexins link synaptic function to cognitive disease. Thomas C SüdhofNature200818923512No
22621913956.549.1324.6A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. N C Andrews, D V FallerNucleic Acids Res.19912041787Yes
2263956956.00.00.0Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J C UnkelessJ. Exp. Med.197990108Yes
2264956956.041.2141.2Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Thomas HebererToxicol. Lett.200211988354Yes
2265955955.031.2231.2Normalization of cell responses in cat striate cortex. D J HeegerVis. Neurosci.19921504027Yes
2266955955.088.1288.1The problem of rigor in qualitative research. M SandelowskiANS Adv Nurs Sci19863083765Yes
2267955955.033.7533.8Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. S L FriedmanN. Engl. J. Med.19938502273No
2268955955.025.8725.9Ordered porous materials for emerging applications. Mark E DavisNature200212075343No
2269955955.020.8220.8Protein kinases--the major drug targets of the twenty-first century? Philip CohenNat Rev Drug Discov200212120282No
2270955955.022.8922.9Assortative mixing in networks. M E J NewmanPhys. Rev. Lett.200212443515Yes
2271955955.024.8824.9Nuclear factor-kappaB: the enemy within. Bharat B AggarwalCancer Cell200415380510No
2272955955.023.3123.3Solving structures of protein complexes by molecular replacement with Phaser. Airlie J McCoyActa Crystallogr. D Biol. Crystallogr.200717164524Yes
22731909954.546.8923.4T-cell antigen receptor genes and T-cell recognition. M M Davis, P J BjorkmanNature19883043226No
2274954954.029.6529.6Surrogate endpoints in clinical trials: definition and operational criteria. R L PrenticeStat Med19892727467Yes
2275953953.026.3926.4Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. T A SpringerAnnu. Rev. Physiol.19957778885No
22761906953.042.1921.1NF-kappaB at the crossroads of life and death. Michael Karin, Anning LinNat. Immunol.200211875461No
2277953953.021.4821.5Mechanisms of caspase activation and inhibition during apoptosis. Yigong ShiMol. Cell200211931755No
2278953953.049.5749.6MorphoJ: an integrated software package for geometric morphometrics. Christian Peter KlingenbergMol Ecol Resour201121429143Yes
22791905952.574.7337.4Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. J I Morgan, T CurranAnnu. Rev. Neurosci.19911903243No
22801905952.50.00.0A new scale of social desirability independent of psychopathology. D P CROWNE, D MARLOWEJ Consult Psychol196013813058Yes
22812857952.3101.2133.7Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. H King, R E Aubert, W H HermanDiabetes Care19989727886Yes
22821904952.063.7231.9Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. R G Phillips, J E LeDouxBehav. Neurosci.19921590953Yes
2283952952.047.1847.2Multiple calcium channels and neuronal function. R J MillerScience19872432656No
2284952952.036.236.2The human immunodeficiency virus: infectivity and mechanisms of pathogenesis. A S FauciScience19883277274No
2285952952.047.7947.8Biology of interleukin 1. C A DinarelloFASEB J.19883277884No
2286952952.023.3223.3Stem cells in the central nervous system. R McKayScience19979082987No
22871904952.046.1623.1Toll-like receptors in the induction of the innate immune response. A Aderem, R J UlevitchNature200010963608No
2288952952.00.00.0Fluorescent antibody methods. A H COONSGen Cytochem Methods195813574437Yes
22891904952.057.7128.9Therapeutic potential of resveratrol: the in vivo evidence. Joseph A Baur, David A SinclairNat Rev Drug Discov200616732220No
22903807951.8102.0925.5A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Vsevolod V Rostovtsev, Luke G Green, Valery V Fokin, K Barry SharplessAngew. Chem. Int. Ed. Engl.200212203546Yes
22911903951.580.4740.2The framing of decisions and the psychology of choice. A Tversky, D KahnemanScience19817455683Yes
22921903951.561.1630.6Meeting of minds: the medial frontal cortex and social cognition. David M Amodio, Chris D FrithNat. Rev. Neurosci.200616552413No
22931902951.0126.7263.4A study of the natural history of back pain. Part I: development of a reliable and sensitive measure of disability in low-back pain. M Roland, R MorrisSpine19836222486Yes
2294951951.043.9544.0Categorical Data Analysis: Away from ANOVAs (transformation or not) and towards Logit Mixed Models. T Florian JaegerJ Mem Lang200819884961Yes
2295951951.053.9153.9Exploring Structure-Activity Data Using the Landscape Paradigm. Rajarshi GuhaWiley Interdiscip Rev Comput Mol Sci201224163705Yes
22961901950.537.5318.8Hedgehog signaling in animal development: paradigms and principles. P W Ingham, A P McMahonGenes Dev.200111731473No
2297950950.030.8830.9Internal models for motor control and trajectory planning. M KawatoCurr. Opin. Neurobiol.199910607637No
22981899949.585.3942.7Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants. Sarvajeet Singh Gill, Narendra TutejaPlant Physiol. Biochem.201020870416No
2299949949.025.5225.5The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. G B MorinCell19892805070Yes
2300949949.031.1731.2Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis. C TaswellJ. Immunol.19817009746Yes
2301949949.023.7123.7Version 1.2 of the Crystallography and NMR system. Axel T BrungerNat Protoc200718007608Yes
23021897948.554.8327.4Regulation mechanisms and signaling pathways of autophagy. Congcong He, Daniel J KlionskyAnnu. Rev. Genet.200919653858No
23031897948.557.5728.8Cell signaling by receptor tyrosine kinases. Mark A Lemmon, Joseph SchlessingerCell201020602996No
2304948948.00.00.0Refinement of the coomassie blue method of protein quantitation. A simple and linear spectrophotometric assay for less than or equal to 0.5 to 50 microgram of protein. T SpectorAnal. Biochem.1978655375Yes
2305948948.042.0442.0The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. A RaineSchizophr Bull19911805349Yes
2306948948.024.1824.2The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. S E KahnDiabetologia200312637977No
23071895947.563.7531.9Increasing incidence of thyroid cancer in the United States, 1973-2002. Louise Davies, H Gilbert WelchJAMA200616684987Yes
2308947947.00.00.0Optimal foraging, the marginal value theorem. E L CharnovTheor Popul Biol19761273796Yes
2309947947.050.1150.1A cochlear frequency-position function for several species--29 years later. D D GreenwoodJ. Acoust. Soc. Am.19902373794Yes
2310947947.029.7329.7Understanding biofilm resistance to antibacterial agents. David DaviesNat Rev Drug Discov200312563302No
23111893946.576.8838.4Oxidative mechanisms in the toxicity of metal ions. S J Stohs, D BagchiFree Radic. Biol. Med.19957744317No
2312946946.063.5263.5The determinants of parenting: a process model. J BelskyChild Dev19846705636Yes
2313946946.030.0630.1Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Earl S FordDiabetes Care200515983333No
23142838946.065.9722.0Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM). Michael J Rust, Mark Bates, Xiaowei ZhuangNat. Methods200616896339Yes
2315946946.00.00.0Note on the sampling error of the difference between correlated proportions or percentages. Q McNEMARPsychometrika194720254758Yes
2316945945.023.2523.2The finer things in X-ray diffraction data collection. J W PflugrathActa Crystallogr. D Biol. Crystallogr.199910531521Yes
2317945945.00.00.0A personality scale of manifest anxiety. J A TAYLORJ Abnorm Psychol195313052352Yes
23181890945.0122.3861.2A new initiative on precision medicine. Francis S Collins, Harold VarmusN. Engl. J. Med.201525635347Yes
2319944944.024.9124.9Next-generation DNA sequencing methods. Elaine R MardisAnnu Rev Genomics Hum Genet200818576944No
23201887943.50.00.0Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. G Blobel, B DobbersteinJ. Cell Biol.1975811671Yes
2321943943.033.3333.3Analyzing the mosaic structure of genes. J M SmithJ. Mol. Evol.19921556748No
23221886943.055.5327.8Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Uwe-Karsten Hanisch, Helmut KettenmannNat. Neurosci.200717965659No
23231885942.545.6822.8Sequence logos: a new way to display consensus sequences. T D Schneider, R M StephensNucleic Acids Res.19902172928Yes
2324942942.022.3822.4Chromosomal translocations in human cancer. T H RabbittsNature19947969446No
2325942942.024.2924.3Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic Analysis. TirionPhys. Rev. Lett.199610063201Yes
2326942942.046.746.7Translating social ecological theory into guidelines for community health promotion. D StokolsAm J Health Promot199610159709No
2327942942.024.7124.7DNA damage, aging, and cancer. Jan H J HoeijmakersN. Engl. J. Med.200919812404No
2328941941.034.3234.3A Wilcoxon-type test for trend. J CuzickStat Med19853992076Yes
23291881940.50.00.0Glutathione peroxidase activity in selenium-deficient rat liver. R A Lawrence, R F BurkBiochem. Biophys. Res. Commun.1976971321Yes
23301881940.50.00.0Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. R L Heath, L PackerArch. Biochem. Biophys.19685655425Yes
2331940940.020.1820.2Regulation of phosphoinositide-specific phospholipase C. S G RheeAnnu. Rev. Biochem.200111395409No
2332940940.024.1224.1Neurobiology of Pavlovian fear conditioning. S MarenAnnu. Rev. Neurosci.200111520922No
23331880940.059.0229.5Nanostructures in biodiagnostics. Nathaniel L Rosi, Chad A MirkinChem. Rev.200515826019No
23341880940.054.727.4Microenvironmental regulation of metastasis. Johanna A Joyce, Jeffrey W PollardNat. Rev. Cancer200919279573No
23351879939.572.5436.3Porosity of 3D biomaterial scaffolds and osteogenesis. Vassilis Karageorgiou, David KaplanBiomaterials200515860204No
2336939939.027.9828.0Molecular themes in oncogenesis. J M BishopCell19911988146No
23375634939.0164.3327.4Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research. Ana Conesa, Stefan Götz, Juan Miguel García-Gómez, Javier Terol, Manuel Talón, Montserrat RoblesBioinformatics200516081474Yes
2338939939.023.8423.8Recognition and processing of ubiquitin-protein conjugates by the proteasome. Daniel FinleyAnnu. Rev. Biochem.200919489727No
23391877938.558.1429.1Genetic dissection of complex traits. E S Lander, N J SchorkScience19948091226No
23401877938.540.5520.3Rho GTPases: biochemistry and biology. Aron B Jaffe, Alan HallAnnu. Rev. Cell Dev. Biol.200516212495No
23411876938.051.6725.8The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications. P M Sharp, W H LiNucleic Acids Res.19873547335Yes
2342938938.024.7724.8Heterotrimeric G proteins: organizers of transmembrane signals. E J NeerCell19957834744No
2343938938.016.916.9Mitotic kinases as regulators of cell division and its checkpoints. E A NiggNat. Rev. Mol. Cell Biol.200111413462No
23442813937.7128.7642.9Structure-antioxidant activity relationships of flavonoids and phenolic acids. C A Rice-Evans, N J Miller, G PagangaFree Radic. Biol. Med.19968743980Yes
23452812937.380.7226.9Functional diversity of helper T lymphocytes. A K Abbas, K M Murphy, A SherNature19968893001No
2346937937.021.8921.9Regulation of transcription by MAP kinase cascades. R TreismanCurr. Opin. Cell Biol.19968791420No
23472811937.064.5121.5Large-scale analysis of the yeast proteome by multidimensional protein identification technology. M P Washburn, D Wolters, J R YatesNat. Biotechnol.200111231557Yes
2348937937.035.4935.5Endometriosis. Serdar E BulunN. Engl. J. Med.200919144942No
23491873936.50.00.0Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. G J TODARO, H GREENJ. Cell Biol.196313985244Yes
2350936936.056.4956.5What's in a name? Qualitative description revisited. Margarete SandelowskiRes Nurs Health201020014004Yes
23511872936.074.6837.3Plasmonics for improved photovoltaic devices. Harry A Atwater, Albert PolmanNat Mater201020168344Yes
23521871935.542.2921.1Plant pathogens and integrated defence responses to infection. J L Dangl, J D JonesNature200111459065No
23532806935.3106.5835.5Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. S van der Linden, H A Valkenburg, A CatsArthritis Rheum.19846231933Yes
23542806935.377.0525.7Tissue cells feel and respond to the stiffness of their substrate. Dennis E Discher, Paul Janmey, Yu-Li WangScience200516293750No
2355935935.022.8422.8Antigen-specific interaction between T and B cells. A LanzavecchiaNature19853157869Yes
2356935935.047.1147.1An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. J Kabat-ZinnGen Hosp Psychiatry19827042457Yes
23571870935.062.4831.2Epidemiology and outcomes of osteoporotic fractures. Steven R Cummings, L Joseph MeltonLancet200212049882No
23581870935.047.9724.0Can the pharmaceutical industry reduce attrition rates? Ismail Kola, John LandisNat Rev Drug Discov200415286737No
23591870935.046.8623.4Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Eugenia E Calle, Rudolf KaaksNat. Rev. Cancer200415286738No
23602804934.7102.5334.2The functional anatomy of basal ganglia disorders. R L Albin, A B Young, J B PenneyTrends Neurosci.19892479133No
23611869934.544.3422.2The mammalian unfolded protein response. Martin Schröder, Randal J KaufmanAnnu. Rev. Biochem.200515952902No
2362934934.00.00.0Dopamine (3-hydroxytyramine) and brain function. O HornykiewiczPharmacol. Rev.19665328389No
2363934934.036.4536.5The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. J L CummingsNeurology19979153155No
2364934934.023.823.8Topoisomerase I inhibitors: camptothecins and beyond. Yves PommierNat. Rev. Cancer200616990856No
23651867933.596.9848.5Reading senseless sentences: brain potentials reflect semantic incongruity. M Kutas, S A HillyardScience19807350657Yes
2366933933.054.2954.3Free-radical mechanisms in tissue injury. T F SlaterBiochem. J.19846383353No
23671866933.00.00.0Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. H J BLOOM, W W RICHARDSONBr. J. Cancer195713499785Yes
2368933933.035.0935.1Recent developments in isocyanide based multicomponent reactions in applied chemistry. Alexander DömlingChem. Rev.200616402771No
23691864932.044.9122.5Atherosclerosis. the road ahead. C K Glass, J L WitztumCell200111239408No
2370932932.018.4718.5The development of neural stem cells. S TempleNature200111689956No
23711864932.036.6818.3Stats: transcriptional control and biological impact. David E Levy, J E DarnellNat. Rev. Mol. Cell Biol.200212209125No
2372932932.030.4930.5Physiology and pathophysiology of purinergic neurotransmission. Geoffrey BurnstockPhysiol. Rev.200717429044No
2373932932.031.3931.4The origins of the developmental origins theory. D J P BarkerJ. Intern. Med.200717444880No
23741864932.071.4435.7Chronic hepatitis B: update 2009. Anna S F Lok, Brian J McMahonHepatology200919714720Yes
23751863931.584.4742.2Total energy intake: implications for epidemiologic analyses. W Willett, M J StampferAm. J. Epidemiol.19863521261No
23761863931.550.6725.3Next-generation DNA sequencing. Jay Shendure, Hanlee JiNat. Biotechnol.200818846087Yes
23772794931.373.6724.6Hepatocellular carcinoma. Josep M Llovet, Andrew Burroughs, Jordi BruixLancet200314667750No
23782793931.066.8522.3Predicting coiled coils from protein sequences. A Lupas, M Van Dyke, J StockScience19912031185Yes
2379931931.00.00.0The carbon dioxide hydration activity of carbonic anhydrase. I. Stop-flow kinetic studies on the native human isoenzymes B and C. R G KhalifahJ. Biol. Chem.19714994926Yes
23801861930.548.0724.0Toll-like receptors in innate immunity. Kiyoshi Takeda, Shizuo AkiraInt. Immunol.200515585605No
23811861930.561.0730.5The cognitive control of emotion. Kevin N Ochsner, James J GrossTrends Cogn. Sci. (Regul. Ed.)200515866151No
23821861930.559.8429.9Molecular mechanisms of long noncoding RNAs. Kevin C Wang, Howard Y ChangMol. Cell201121925379No
2383930930.029.4529.4The basic science of gene therapy. R C MulliganScience19938493530No
2384930930.037.4537.5Stress and disorders of the stress system. George P ChrousosNat Rev Endocrinol200919488073No
2385930930.053.9453.9Pro-resolving lipid mediators are leads for resolution physiology. Charles N SerhanNature201424899309No
23863719929.8137.8634.5Place navigation impaired in rats with hippocampal lesions. R G Morris, P Garrud, J N Rawlins, J O'KeefeNature19827088155Yes
2387929929.034.0934.1The structure of common mental disorders. R F KruegerArch. Gen. Psychiatry199910530634Yes
23883714928.5126.9831.7Prevalence and trends in obesity among US adults, 1999-2000. Katherine M Flegal, Margaret D Carroll, Cynthia L Ogden, Clifford L JohnsonJAMA200212365955Yes
23891857928.544.1122.1Tumorigenesis and the angiogenic switch. Gabriele Bergers, Laura E BenjaminNat. Rev. Cancer200312778130No
23902785928.383.127.7Dystrophin: the protein product of the Duchenne muscular dystrophy locus. E P Hoffman, R H Brown, L M KunkelCell19873319190Yes
23911856928.075.7937.9The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. W R Gibb, A J LeesJ. Neurol. Neurosurg. Psychiatry19882841426No
2392928928.019.0919.1Antigen receptor tail clue. M RethNature19892927501Yes
2393928928.043.4243.4Quantitative methods in the review of epidemiologic literature. S GreenlandEpidemiol Rev19873678409Yes
2394928928.026.5426.5Neurons with graded response have collective computational properties like those of two-state neurons. J J HopfieldProc. Natl. Acad. Sci. U.S.A.19846587342Yes
2395928928.036.9737.0The aging process. D HarmanProc. Natl. Acad. Sci. U.S.A.19816947277Yes
2396928928.022.2522.2Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. Harold F DvorakJ. Clin. Oncol.200212409337No
2397928928.020.0520.1Microarray data normalization and transformation. John QuackenbushNat. Genet.200212454644No
2398928928.00.00.0Method for the determination of hexosamines in tissues. N F BOASJ. Biol. Chem.195313117829Yes
2399928928.033.5633.6High prevalence of vitamin D inadequacy and implications for health. Michael F HolickMayo Clin. Proc.200616529140No
24002783927.7119.6839.9Rehospitalizations among patients in the Medicare fee-for-service program. Stephen F Jencks, Mark V Williams, Eric A ColemanN. Engl. J. Med.200919339721Yes
24011855927.544.2622.1NF-kappaB: linking inflammation and immunity to cancer development and progression. Michael Karin, Florian R GretenNat. Rev. Immunol.200516175180No
24022782927.394.6531.6Nitric oxide and peroxynitrite in health and disease. Pál Pacher, Joseph S Beckman, Lucas LiaudetPhysiol. Rev.200717237348No
24031854927.00.00.0Method for the isolation of intact islets of Langerhans from the rat pancreas. P E Lacy, M KostianovskyDiabetes19675333500Yes
2404927927.021.1121.1Inferences, questions and possibilities in Toll-like receptor signalling. Bruce BeutlerNature200415241424No
24052781927.0135.7945.3Effect of the damping function in dispersion corrected density functional theory. Stefan Grimme, Stephan Ehrlich, Lars GoerigkJ Comput Chem201121370243Yes
24062780926.775.8525.3Long non-coding RNAs: insights into functions. Tim R Mercer, Marcel E Dinger, John S MattickNat. Rev. Genet.200919188922No
2407926926.029.6129.6Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Paul WillnerNeuropsychobiology200516037678No
24081851925.570.9135.5Mediation in experimental and nonexperimental studies: new procedures and recommendations. Patrick E Shrout, Niall BolgerPsychol Methods200212530702Yes
2409925925.019.719.7Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. R RothsteinMeth. Enzymol.19912005793Yes
2410925925.033.4833.5Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. W SieghartPharmacol. Rev.19957568326No
2411925925.035.3935.4Depression in late life: review and commentary. Dan G BlazerJ. Gerontol. A Biol. Sci. Med. Sci.200312634292No
2412925925.00.00.0A modified ninhydrin colorimetric analysis for amino acids. H ROSENArch. Biochem. Biophys.195713412116Yes
2413925925.028.7228.7Reconciling the chemistry and biology of reactive oxygen species. Christine C WinterbournNat. Chem. Biol.200818421291No
2414925925.040.1640.2Matching methods for causal inference: A review and a look forward. Elizabeth A StuartStat Sci201020871802Yes
24151848924.00.00.0Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. C B Lozzio, B B LozzioBlood1975163658Yes
2416924924.059.4859.5Adjustments to Zatsiorsky-Seluyanov's segment inertia parameters. P de LevaJ Biomech19968872282Yes
2417924924.025.3625.4Physiological and molecular basis of thyroid hormone action. P M YenPhysiol. Rev.200111427693No
2418924924.00.00.0Intra-sexual selection in Drosophila. A J BATEMANHeredity (Edinb)194818103134Yes
2419924924.033.733.7Chlorophyll fluorescence: a probe of photosynthesis in vivo. Neil R BakerAnnu Rev Plant Biol200818444897No
24201847923.596.5148.3Numerical index of the discriminatory ability of typing systems: an application of Simpson's index of diversity. P R Hunter, M A GastonJ. Clin. Microbiol.19883069867Yes
24211847923.562.3931.2Antibiotic resistance of bacteria in biofilms. P S Stewart, J W CostertonLancet200111463434No
24222769923.055.5318.5Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. S Moreno, A Klar, P NurseMeth. Enzymol.19912005825Yes
2423923923.00.00.0An improved procedure for serum creatine phosphokinase determination. S B RosalkiJ. Lab. Clin. Med.19674381359Yes
2424923923.00.00.0Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J AltmanJ. Comp. Neurol.19695361244Yes
24252768922.7106.3935.5Estimating the mean and variance from the median, range, and the size of a sample. Stela Pudar Hozo, Benjamin Djulbegovic, Iztok HozoBMC Med Res Methodol200515840177Yes
24261845922.575.637.8Intracellular pH. A Roos, W F BoronPhysiol. Rev.19817012859No
2427922922.043.3543.4Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. M A LempCLAO J19958565190No
2428922922.030.6230.6Stress and depression. Constance HammenAnnu Rev Clin Psychol200517716090No
2429922922.028.7428.7Hydrogen sulphide and its therapeutic potential. Csaba SzabóNat Rev Drug Discov200717948022No
24306451921.6343.6949.1Development and validation of a geriatric depression screening scale: a preliminary report. J A Yesavage, T L Brink, T L Rose, O Lum, V Huang, M Adey, V O LeirerJ Psychiatr Res19827183759Yes
2431921921.035.5435.5Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing. M J GassonJ. Bacteriol.19836403500Yes
2432921921.023.0523.1Platelets in atherothrombosis. Zaverio M RuggeriNat. Med.200212411949No
2433921921.047.8247.8Antibiotics in the aquatic environment--a review--part I. Klaus KümmererChemosphere200919185900No
2434921921.035.5835.6Signal transduction by reactive oxygen species. Toren FinkelJ. Cell Biol.201121746850No
24351842921.0105.5652.8Multiwfn: a multifunctional wavefunction analyzer. Tian Lu, Feiwu ChenJ Comput Chem201222162017Yes
24365524920.7194.4632.4Cancer statistics, 2007. Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward, Taylor Murray, Jiaquan Xu, Michael J ThunCA Cancer J Clin200717237035Yes
24371841920.558.529.2Apoptosis, oncosis, and necrosis. An overview of cell death. G Majno, I JorisAm. J. Pathol.19957856735No
2438920920.00.00.0Protein denaturation. C. Theoretical models for the mechanism of denaturation. C TanfordAdv. Protein Chem.19704912353No
2439920920.023.3223.3The Unified Medical Language System (UMLS): integrating biomedical terminology. Olivier BodenreiderNucleic Acids Res.200414681409Yes
2440920920.038.7138.7Aging, cellular senescence, and cancer. Judith CampisiAnnu. Rev. Physiol.201323140366No
2441919919.048.5248.5Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. G A McPhersonJ Pharmacol Methods19853840547Yes
24421838919.043.3521.7Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. C W Greider, E H BlackburnCell19853907856Yes
24434595919.00.00.0Transection of the oesophagus for bleeding oesophageal varices. R N Pugh, I M Murray-Lyon, J L Dawson, M C Pietroni, R WilliamsBr J Surg19734541913Yes
2444919919.033.4433.4Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. P S ToftsJ Magn Reson Imaging19979039598No
2445919919.025.9225.9Oxyradicals and DNA damage. L J MarnettCarcinogenesis200010688856No
24462756918.70.00.0Improved method for the determination of blood glutathione. E BEUTLER, O DURON, B M KELLYJ. Lab. Clin. Med.196313967893Yes
24472754918.0190.5963.5Some statistical methods useful in circulation research. S Wallenstein, C L Zucker, J L FleissCirc. Res.19807379260Yes
2448918918.024.724.7The prefrontal cortex and cognitive control. E K MillerNat. Rev. Neurosci.200011252769No
2449918918.029.6729.7How brains beware: neural mechanisms of emotional attention. Patrik VuilleumierTrends Cogn. Sci. (Regul. Ed.)200516289871Yes
2450918918.028.8228.8Polymer conjugates as anticancer nanomedicines. Ruth DuncanNat. Rev. Cancer200616900224No
2451918918.028.8728.9Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. G L SemenzaOncogene201019946328No
24521836918.059.4529.7Regulation of chromatin by histone modifications. Andrew J Bannister, Tony KouzaridesCell Res.201121321607No
24532754918.0150.5850.2Molecular mechanisms of epithelial-mesenchymal transition. Samy Lamouille, Jian Xu, Rik DerynckNat. Rev. Mol. Cell Biol.201424556840No
24541835917.50.00.0Radiological demarcation of cemented sockets in total hip replacement. J G DeLee, J CharnleyClin. Orthop. Relat. Res.1976991504Yes
2455917917.042.5342.5The theoretical bases of indirect calorimetry: a review. E FerranniniMetab. Clin. Exp.19883278194No
2456917917.00.00.0A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. A M OlovnikovJ. Theor. Biol.19734754905Yes
2457917917.00.00.0RNA metabolism in the HeLa cell nucleus. S PenmanJ. Mol. Biol.19665961144Yes
24582751917.0104.234.7MR diffusion tensor spectroscopy and imaging. P J Basser, J Mattiello, D LeBihanBiophys. J.19948130344Yes
2459917917.020.7320.7Mechanisms and consequences of activation of protein kinase B/Akt. J DownwardCurr. Opin. Cell Biol.19989561851No
24601834917.045.722.9Defining the role of mTOR in cancer. David A Guertin, David M SabatiniCancer Cell200717613433No
24611834917.073.0136.5Oxidative stress and diabetic complications. Ferdinando Giacco, Michael BrownleeCirc. Res.201021030723No
24621833916.546.1423.1Lymphocyte homing and homeostasis. E C Butcher, L J PickerScience19968600538No
2463916916.029.3529.4Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology. E M TanAdv. Immunol.19892646863No
2464916916.018.4618.5Regulatory T cells in autoimmmunity*. E M ShevachAnnu. Rev. Immunol.200010837065No
2465916916.020.220.2Regulation of cadherin-mediated adhesion in morphogenesis. Barry M GumbinerNat. Rev. Mol. Cell Biol.200516025097No
24661831915.560.5930.3Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Robert E W Hancock, Hans-Georg SahlNat. Biotechnol.200617160061No
2467915915.032.1432.1Papillary and follicular thyroid carcinoma. M J SchlumbergerN. Engl. J. Med.19989445411No
2468915915.030.8130.8Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. P LipsEndocr. Rev.200111493580No
2469915915.023.3423.3Microglia as a source and target of cytokines. Uwe-Karsten HanischGlia200212379902No
2470915915.00.00.0Sequential tests for the detection of linkage. N E MORTONAm. J. Hum. Genet.195513258560Yes
2471915915.00.00.0Starch gel electrophoresis in a discontinous system of buffers. M D POULIKNature195713493570Yes
2472915915.024.9825.0Evaluating medication effects outside of clinical trials: new-user designs. Wayne A RayAm. J. Epidemiol.200314585769Yes
24731829914.540.6920.3Genomic control for association studies. B Devlin, K RoederBiometrics199911315092Yes
2474914914.044.3444.3Social phobia. M R LiebowitzMod Probl Pharmacopsychiatry19872885745Yes
2475914914.024.9625.0Brain tumors. L M DeAngelisN. Engl. J. Med.200111150363No
24763656914.081.4320.4Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. L Alexopoulou, A C Holt, R Medzhitov, R A FlavellNature200111607032Yes
2477914914.038.138.1Risk and maintenance factors for eating pathology: a meta-analytic review. Eric SticePsychol Bull200212206196No
2478914914.035.6235.6A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Ozcan ErelClin. Biochem.200415003729Yes
2479913913.051.351.3Substance P. B PernowPharmacol. Rev.19836196797No
24801826913.064.1732.1Nitric oxide synthases: roles, tolls, and controls. C Nathan, Q W XieCell19947522969No
2481913913.027.727.7Somatostatin and its receptor family. Y C PatelFront Neuroendocrinol199910433861No
2482913913.029.6129.6Neural simulation of action: a unifying mechanism for motor cognition. M JeannerodNeuroimage200111373140No
24832739913.095.4531.8Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Günter Oberdörster, Eva Oberdörster, Jan OberdörsterEnviron. Health Perspect.200516002369No
2484913913.00.00.0On the Absorption of Fluids from the Connective Tissue Spaces. E H StarlingJ. Physiol. (Lond.)189616992325Yes
24851826913.055.1627.6Myocardial reperfusion injury. Derek M Yellon, Derek J HausenloyN. Engl. J. Med.200717855673No
2486913913.021.6721.7Evo-devo and an expanding evolutionary synthesis: a genetic theory of morphological evolution. Sean B CarrollCell200818614008Yes
2487912912.040.940.9The LMS method for constructing normalized growth standards. T J ColeEur J Clin Nutr19902354692Yes
2488912912.00.00.0Bee and wasp venoms. E HabermannScience19724113805No
2489912912.046.8546.9Neuropeptide Y: complete amino acid sequence of the brain peptide. K TatemotoProc. Natl. Acad. Sci. U.S.A.19826957876Yes
2490912912.030.7130.7Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. J DeisenhoferBiochemistry19817236608Yes
2491912912.030.0630.1Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. M KozakNucleic Acids Res.19817301588Yes
2492912912.025.3725.4Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. R Balfour SartorNat Clin Pract Gastroenterol Hepatol200616819502No
24933648912.0101.2225.3Autophagy fights disease through cellular self-digestion. Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J KlionskyNature200818305538No
24941823911.587.043.5Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Jennifer A Doudna, Emmanuelle CharpentierScience201425430774No
2495911911.031.9131.9The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure. K KuwajimaProteins19892695928No
2496911911.020.720.7Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. Z YangMol. Biol. Evol.19989580986Yes
2497911911.00.00.0The critical incident technique. J C FLANAGANPsychol Bull195413177800Yes
24983641910.20.00.0The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. L A Sternberger, P H Hardy, J J Cuculis, H G MeyerJ. Histochem. Cytochem.19704192899Yes
2499910910.019.5719.6The power and the promise of DNA methylation markers. Peter W LairdNat. Rev. Cancer200312671664No
2500910910.025.625.6Optical microcavities. Kerry J VahalaNature200312917698Yes
2501910910.00.00.0THE FUNCTION OF THE VERTEBRAL VEINS AND THEIR ROLE IN THE SPREAD OF METASTASES. O V BatsonAnn. Surg.194017857618Yes
25021819909.50.00.0Surgical risk as related to time of intervention in the repair of intracranial aneurysms. W E Hunt, R M HessJ. Neurosurg.19685635959Yes
2503909909.036.5236.5Diversity and ubiquity of K channels. B RudyNeuroscience19882457185No
25041818909.098.2349.1Biology of disease: free radicals and tissue injury. B A Freeman, J D CrapoLab. Invest.19826290784No
2505909909.031.931.9Peptide antibiotics and their role in innate immunity. H G BomanAnnu. Rev. Immunol.19957612236No
2506909909.021.4921.5Apoptosis in neurodegenerative disorders. M P MattsonNat. Rev. Mol. Cell Biol.200011253364No
2507909909.037.0937.1Socioeconomic status and obesity. Lindsay McLarenEpidemiol Rev200717478442No
2508908908.00.00.0Regulation of noradrenaline release by presynaptic receptor systems. K StarkeRev. Physiol. Biochem. Pharmacol.197714389No
2509908908.017.1917.2Molecular mechanisms of axon guidance. Barry J DicksonScience200212471249No
2510908908.024.5424.5The path to ubiquitous and low-cost organic electronic appliances on plastic. Stephen R ForrestNature200415118718Yes
2511907907.036.2136.2The matrix-degrading metalloproteinases. L M MatrisianBioessays19921445287No
2512907907.00.00.0Why people use health services. I M RosenstockMilbank Mem Fund Q19665967464Yes
2513907907.027.6927.7Neural systems for recognizing emotion. Ralph AdolphsCurr. Opin. Neurobiol.200212015233No
25141814907.052.8626.4C-reactive protein: a critical update. Mark B Pepys, Gideon M HirschfieldJ. Clin. Invest.200312813013No
2515907907.00.00.0Cellular resistance to infection. G B MACKANESSJ. Exp. Med.196214467923Yes
2516907907.035.7135.7Delirium in older persons. Sharon K InouyeN. Engl. J. Med.200616540616No
2517907907.032.2632.3Multiple imputation of discrete and continuous data by fully conditional specification. Stef van BuurenStat Methods Med Res200717621469Yes
2518906906.030.5230.5Emotion regulation: affective, cognitive, and social consequences. James J GrossPsychophysiology200212212647No
2519906906.034.7634.8Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Charles A DinarelloBlood201121304099No
25201811905.582.4841.2Thermodynamics of protein association reactions: forces contributing to stability. P D Ross, S SubramanianBiochemistry19817248271Yes
25212716905.383.0827.7Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. C R Woese, O Kandler, M L WheelisProc. Natl. Acad. Sci. U.S.A.19902112744Yes
2522905905.00.00.0Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. D B ClewellJ. Bacteriol.19724336693Yes
25231810905.045.5822.8Synaptic activity and the construction of cortical circuits. L C Katz, C J ShatzScience19968895456No
2524905905.026.4126.4Metabolism and functions of glutathione in brain. R DringenProg. Neurobiol.200010880854No
2525905905.030.2130.2Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Antoine BecharaNat. Neurosci.200516251988No
25261809904.568.0734.0The benefits of being present: mindfulness and its role in psychological well-being. Kirk Warren Brown, Richard M RyanJ Pers Soc Psychol200312703651Yes
2527904904.00.00.0The intraclass correlation coefficient as a measure of reliability. J J BartkoPsychol Rep19665942109Yes
2528904904.058.5558.5Optical properties of biological tissues: a review. Steven L JacquesPhys Med Biol201323666068No
25292710903.378.5626.2Wnt/beta-catenin signaling: components, mechanisms, and diseases. Bryan T MacDonald, Keiko Tamai, Xi HeDev. Cell200919619488No
2530903903.033.2333.2Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. P J BasserNMR Biomed19958739270No
2531903903.023.2323.2Human natural killer cells. Michael A CaligiuriBlood200818650461No
25321804902.00.00.0Selective loss of central cholinergic neurons in Alzheimer's disease. P Davies, A J MaloneyLancet197663862Yes
25331804902.064.9232.5Recent advances in the phencyclidine model of schizophrenia. D C Javitt, S R ZukinAm J Psychiatry19911654746No
2534902902.031.4231.4General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids. R A HoughtenProc. Natl. Acad. Sci. U.S.A.19852410914Yes
2535902902.039.7839.8Volumetric modulated arc therapy: IMRT in a single gantry arc. Karl OttoMed Phys200818293586Yes
2536901901.034.2434.2Relations between the statistics of natural images and the response properties of cortical cells. D J FieldJ Opt Soc Am A19873430225Yes
25371802901.088.544.2The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. R Näätänen, T PictonPsychophysiology19873615753Yes
2538901901.033.8533.9El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. Subcommittee on Motor Neuron Diseases/Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial "Clinical limits of amyotrophic lateral sclerosis" workshop contributors. B R BrooksJ. Neurol. Sci.19947807156Yes
2539901901.029.5629.6The neurobiology of stress: from serendipity to clinical relevance. B S McEwenBrain Res.200011119695No
2540901901.025.9726.0The blood-brain barrier: bottleneck in brain drug development. William M PardridgeNeuroRx200515717053No
25415403900.5205.534.2Prevalence of overweight and obesity in the United States, 1999-2004. Cynthia L Ogden, Margaret D Carroll, Lester R Curtin, Margaret A McDowell, Carolyn J Tabak, Katherine M FlegalJAMA200616595758Yes
25423601900.2118.4129.6Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Michael J Pencina, Ralph B D'Agostino, Ralph B D'Agostino, Ramachandran S VasanStat Med200817569110Yes
2543900900.032.4232.4Reducing children's television viewing to prevent obesity: a randomized controlled trial. T N RobinsonJAMA199910546696Yes
2544900900.018.9619.0Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Ricky W JohnstoneNat Rev Drug Discov200212120280No
25451800900.0277.65138.8A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. Terry K Koo, Mae Y LiJ Chiropr Med201627330520Yes
25461799899.558.5929.3Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Ajay Kumar Gupta, Mona GuptaBiomaterials200515626447No
2547899899.047.1847.2Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. S H SafeCrit. Rev. Toxicol.19948037844No
2548899899.018.2518.2Biological robustness. Hiroaki KitanoNat. Rev. Genet.200415520792No
2549899899.033.0933.1Understanding organofluorine chemistry. An introduction to the C-F bond. David O'HaganChem Soc Rev200818197347No
25501796898.0147.1273.6A joint coordinate system for the clinical description of three-dimensional motions: application to the knee. E S Grood, W J SuntayJ Biomech Eng19836865355Yes
2551898898.034.3934.4The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions. R G GerrityAm. J. Pathol.19817234961Yes
2552898898.030.5430.5The biochemistry and medical significance of the flavonoids. Bent H HavsteenPharmacol. Ther.200212453566No
25531796898.059.1729.6Alternative activation of macrophages: mechanism and functions. Siamon Gordon, Fernando O MartinezImmunity201020510870No
2554897897.024.824.8Metastatic bone disease: clinical features, pathophysiology and treatment strategies. R E ColemanCancer Treat. Rev.200111417967No
25553587896.8108.1927.0Microbial ecology: human gut microbes associated with obesity. Ruth E Ley, Peter J Turnbaugh, Samuel Klein, Jeffrey I GordonNature200617183309Yes
2556896896.039.4739.5Hydrophilic-interaction chromatography for the separation of peptides, nucleic acids and other polar compounds. A J AlpertJ. Chromatogr.19902324207Yes
25571792896.077.4338.7Unidentified curved bacilli on gastric epithelium in active chronic gastritis. J R Warren, B MarshallLancet19836134060Yes
25581792896.00.00.0Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. H A EDMONDSON, P E STEINERCancer195413160935Yes
25591792896.039.2119.6A general framework for weighted gene co-expression network analysis. Bin Zhang, Steve HorvathStat Appl Genet Mol Biol200516646834Yes
25601792896.047.0423.5Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Jing Yang, Robert A WeinbergDev. Cell200818539112No
2561895895.033.9333.9Antecedent- and response-focused emotion regulation: divergent consequences for experience, expression, and physiology. J J GrossJ Pers Soc Psychol19989457784Yes
2562895895.021.5621.6Phenotypic plasticity and the epigenetics of human disease. Andrew P FeinbergNature200717522677No
2563895895.040.3940.4Optimal caliper widths for propensity-score matching when estimating differences in means and differences in proportions in observational studies. Peter C AustinPharm Stat201120925139Yes
25642684894.790.4130.1Molecular characterization of a peripheral receptor for cannabinoids. S Munro, K L Thomas, M Abu-ShaarNature19937689702Yes
25651789894.555.1127.6Chlorophyll fluorescence--a practical guide. K Maxwell, G N JohnsonJ. Exp. Bot.200010938857No
25661789894.546.4323.2Escaping free-energy minima. Alessandro Laio, Michele ParrinelloProc. Natl. Acad. Sci. U.S.A.200212271136Yes
25672683894.378.4826.2LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. A C Wallace, R A Laskowski, J M ThorntonProtein Eng.19957630882Yes
2568894894.00.00.0Simple methods for "staining with lead" at high pH in electron microscopy. M J KARNOVSKYJ Biophys Biochem Cytol196114454024Yes
2569894894.024.5824.6Huntington's disease. Francis O WalkerLancet200717240289No
25701787893.590.645.3A simple method to assess exercise behavior in the community. G Godin, R J ShephardCan J Appl Sport Sci19854053261Yes
25712680893.3104.134.7Oxidants, antioxidants, and the degenerative diseases of aging. B N Ames, M K Shigenaga, T M HagenProc. Natl. Acad. Sci. U.S.A.19938367443No
2572893893.019.5119.5Focal adhesion kinase: the first ten years. J Thomas ParsonsJ. Cell. Sci.200312640026No
2573893893.020.8720.9Protein tyrosine phosphatases: from genes, to function, to disease. Nicholas K TonksNat. Rev. Mol. Cell Biol.200617057753No
2574893893.034.0734.1The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Artemis P SimopoulosExp. Biol. Med. (Maywood)200818408140No
25751784892.042.1321.1Checkpoints: controls that ensure the order of cell cycle events. L H Hartwell, T A WeinertScience19892683079No
2576892892.029.5529.6Pathogenesis of dengue: challenges to molecular biology. S B HalsteadScience19883277268No
2577892892.052.3852.4Biomaterial-centered infection: microbial adhesion versus tissue integration. A G GristinaScience19873629258Yes
2578892892.021.0521.1Microsatellites: simple sequences with complex evolution. Hans EllegrenNat. Rev. Genet.200415153996No
25791784892.087.0243.5The integrative review: updated methodology. Robin Whittemore, Kathleen KnaflJ Adv Nurs200516268861Yes
25805349891.5145.3124.2Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Hadi Valadi, Karin Ekström, Apostolos Bossios, Margareta Sjöstrand, James J Lee, Jan O LötvallNat. Cell Biol.200717486113Yes
25811783891.554.1627.1Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments. Gerard Talavera, Jose CastresanaSyst. Biol.200717654362Yes
258212480891.4310.0422.1Crystallography & NMR system: A new software suite for macromolecular structure determination. A T Brünger, P D Adams, G M Clore, W L DeLano, P Gros, R W Grosse-Kunstleve, J S Jiang, J Kuszewski, M Nilges, N S Pannu, R J Read, L M Rice, T Simonson, G L WarrenActa Crystallogr. D Biol. Crystallogr.19989757107Yes
2583891891.00.00.0Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. J H LuftAnat. Rec.19714108333Yes
25841782891.055.027.5Oxidative stress, caloric restriction, and aging. R S Sohal, R WeindruchScience19968658196No
2585891891.020.7720.8Basement membranes: structure, assembly and role in tumour angiogenesis. Raghu KalluriNat. Rev. Cancer200312778132No
2586891891.023.3523.4Personal genomes: The case of the missing heritability. Brendan MaherNature200818987709No
25871781890.50.00.0A protein sequenator. P Edman, G BeggEur. J. Biochem.19676059350Yes
25881780890.00.00.0Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. J M Tanner, R H WhitehouseArch. Dis. Child.1976952550Yes
2589890890.068.268.2Calcium phosphate ceramics as hard tissue prosthetics. M JarchoClin. Orthop. Relat. Res.19817018783No
2590890890.021.7721.8Physiological concentrations of purines and pyrimidines. T W TrautMol. Cell. Biochem.19947877593No
2591890890.027.9628.0The lipocalin protein family: structure and function. D R FlowerBiochem. J.19968761444No
25921780890.049.7324.9Hepatitis C virus infection. G M Lauer, B D WalkerN. Engl. J. Med.200111439948No
2593890890.022.7922.8The myofibroblast in wound healing and fibrocontractive diseases. G GabbianiJ. Pathol.200312845617No
25941780890.044.9322.5The canonical Notch signaling pathway: unfolding the activation mechanism. Raphael Kopan, Maria Xenia G IlaganCell200919379690No
25953560890.0183.946.0Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. David Moher, Alessandro Liberati, Jennifer Tetzlaff, Douglas G AltmanInt J Surg201020171303No
25963558889.5135.1133.8Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Weidner, J P Semple, W R Welch, J FolkmanN. Engl. J. Med.19911701519Yes
25971779889.566.1633.1Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. J L Weber, P E MayAm. J. Hum. Genet.19892916582Yes
25981779889.557.2528.6A neurotrophic model for stress-related mood disorders. Ronald S Duman, Lisa M MonteggiaBiol. Psychiatry200616631126No
25992668889.3110.4136.8Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensions. Aleksandr V Marenich, Christopher J Cramer, Donald G TruhlarJ Phys Chem B200919366259Yes
2600889889.00.00.0Mutation selection and the natural history of cancer. J CairnsNature19751143315Yes
2601889889.00.00.0Cell lines derived from late embryonic stages of Drosophila melanogaster. I SchneiderJ Embryol Exp Morphol19724625067Yes
2602889889.016.6216.6Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. M S WoldAnnu. Rev. Biochem.19979242902No
26033556889.0106.7226.7C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. P M Ridker, C H Hennekens, J E Buring, N RifaiN. Engl. J. Med.200010733371Yes
2604888888.049.2449.2Human agency in social cognitive theory. A BanduraAm Psychol19892782727Yes
2605888888.034.834.8Effect of anoxia on ion distribution in the brain. A J HansenPhysiol. Rev.19853880896No
2606888888.023.3423.3ALSCRIPT: a tool to format multiple sequence alignments. G J BartonProtein Eng.19938433969Yes
2607888888.025.8925.9P-450 metabolites of arachidonic acid in the control of cardiovascular function. Richard J RomanPhysiol. Rev.200211773611No
26081775887.566.333.1Natural products as sources of new drugs over the last 25 years. David J Newman, Gordon M CraggJ. Nat. Prod.200717309302No
2609887887.00.00.0Neuron-glia relationship during granule cell migration in developing cerebellar cortex. A Golgi and electronmicroscopic study in Macacus Rhesus. P RakicJ. Comp. Neurol.19714101340Yes
26101774887.049.9625.0Prediction of protein secondary structure at better than 70% accuracy. B Rost, C SanderJ. Mol. Biol.19938345525Yes
2611887887.027.227.2Drug delivery and targeting. R LangerNature19989579855No
2612887887.029.8429.8Leishmaniasis. B L HerwaldtLancet199910513726No
26131773886.50.00.0A rapid, sensitive, and specific method for the determination of protein in dilute solution. W Schaffner, C WeissmannAnal. Biochem.19734128882Yes
2614886886.025.7625.8Non-Smad pathways in TGF-beta signaling. Ying E ZhangCell Res.200919114990No
26151771885.542.5921.3The Hsp70 and Hsp60 chaperone machines. B Bukau, A L HorwichCell19989476895No
2616885885.055.0955.1A cognitive approach to panic. D M ClarkBehav Res Ther19863741311Yes
2617885885.00.00.0A comparison of canal preparations in straight and curved root canals. S W SchneiderOral Surg. Oral Med. Oral Pathol.19715284110Yes
26181770885.050.7125.4Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Josep M Llovet, Jordi BruixHepatology200312540794No
2619885885.020.6820.7Liver regeneration: from myth to mechanism. Rebecca TaubNat. Rev. Mol. Cell Biol.200415459664No
2620885885.024.4324.4Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Hiroshi TakayanagiNat. Rev. Immunol.200717380158No
26211770885.0101.8850.9Deciphering key features in protein structures with the new ENDscript server. Xavier Robert, Patrice GouetNucleic Acids Res.201424753421Yes
26221769884.569.2934.6Population growth makes waves in the distribution of pairwise genetic differences. A R Rogers, H HarpendingMol. Biol. Evol.19921316531Yes
26233537884.2105.026.2MEGA2: molecular evolutionary genetics analysis software. S Kumar, K Tamura, I B Jakobsen, M NeiBioinformatics200111751241Yes
26241768884.088.8444.4Malondialdehyde determination as index of lipid peroxidation. H H Draper, M HadleyMeth. Enzymol.19902233309Yes
2625884884.022.3422.3MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. R N GermainCell19948293464No
2626884884.025.2725.3Life, death, and the pursuit of apoptosis. E WhiteGenes Dev.19968557188No
2627884884.024.1524.1Aptamers: an emerging class of molecules that rival antibodies in diagnostics. S D JayasenaClin. Chem.199910471678No
26281768884.046.723.4Esophageal cancer. Peter C Enzinger, Robert J MayerN. Engl. J. Med.200314657432No
2629883883.039.8139.8Inflammation in atherosclerosis. Peter LibbyArterioscler. Thromb. Vasc. Biol.201222895665No
2630882882.00.00.0Strategy and tactics in protein chemistry. B S HartleyBiochem. J.19704923920No
2631882882.020.4520.4Osmotic stress signaling and osmoadaptation in yeasts. Stefan HohmannMicrobiol. Mol. Biol. Rev.200212040128No
26321763881.543.7221.9Mitogen-activated protein kinase pathways. M J Robinson, M H CobbCurr. Opin. Cell Biol.19979069255No
26331763881.549.824.9A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. J N Cohn, G TognoniN. Engl. J. Med.200111759645Yes
2634881881.022.6622.7Complement. Second of two parts. M J WalportN. Engl. J. Med.200111297706No
26352643881.095.2931.8Dose translation from animal to human studies revisited. Shannon Reagan-Shaw, Minakshi Nihal, Nihal AhmadFASEB J.200817942826Yes
26362642880.798.1532.7Simultaneous inference in general parametric models. Torsten Hothorn, Frank Bretz, Peter WestfallBiom J200818481363No
2637880880.00.00.0Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. S AvrameasImmunochemistry19694975324Yes
2638880880.00.00.0Studies on phosphatidylcholine vesicles. Formation and physical characteristics. C HuangBiochemistry19695777332Yes
2639880880.063.3863.4Rating scales to assess depression in school-aged children. M KovacsActa Paedopsychiatr19817025571Yes
2640880880.039.8339.8Multimodal approach to control postoperative pathophysiology and rehabilitation. H KehletBr J Anaesth19979175983No
26411759879.50.00.0Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. E Engvall, P PerlmannJ. Immunol.19724113792Yes
26421759879.546.4923.2Quorum sensing in bacteria. M B Miller, B L BasslerAnnu. Rev. Microbiol.200111544353No
26431759879.541.4120.7Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. S W Hell, J WichmannOpt Lett199419844443Yes
2644879879.031.1431.1Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. E N BergmanPhysiol. Rev.19902181501No
2645879879.061.3861.4The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction. G A IlizarovClin. Orthop. Relat. Res.19892912628Yes
2646879879.00.00.0Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. P O SeglenExp. Cell Res.19734358115Yes
26471758879.095.1647.6Rapid procedure for detection and isolation of large and small plasmids. C I Kado, S T LiuJ. Bacteriol.19817009583Yes
2648879879.023.6523.6SETOR: hardware-lighted three-dimensional solid model representations of macromolecules. S V EvansJ Mol Graph19938347566Yes
26491758879.037.4218.7Wnt signaling: a common theme in animal development. K M Cadigan, R NusseGenes Dev.19979407023No
2650879879.021.3421.3Oxidant signals and oxidative stress. Toren FinkelCurr. Opin. Cell Biol.200312648682No
26511758879.051.7725.9Drug delivery systems: entering the mainstream. Theresa M Allen, Pieter R CullisScience200415031496Yes
2652879879.00.00.0A new readability yardstick. R FLESCHJ Appl Psychol194818867058Yes
2653879879.046.6646.7Cognitive reserve in ageing and Alzheimer's disease. Yaakov SternLancet Neurol201223079557No
26542635878.357.1519.1The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Fabio Martinon, Kimberly Burns, Jürg TschoppMol. Cell200212191486Yes
26554391878.2276.755.3Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. N Bellamy, W W Buchanan, C H Goldsmith, J Campbell, L W StittJ. Rheumatol.19883068365Yes
26563513878.293.4823.4Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. G L Wang, B H Jiang, E A Rue, G L SemenzaProc. Natl. Acad. Sci. U.S.A.19957539918Yes
26575269878.2150.8325.1GROMACS: fast, flexible, and free. David Van Der Spoel, Erik Lindahl, Berk Hess, Gerrit Groenhof, Alan E Mark, Herman J C BerendsenJ Comput Chem200516211538Yes
26581756878.038.1119.1CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. A M Thornton, E M ShevachJ. Exp. Med.19989670041Yes
26591756878.066.2833.1A cognitive model of posttraumatic stress disorder. A Ehlers, D M ClarkBehav Res Ther200010761279No
2660878878.024.2624.3Current concepts of the pathogenesis of the acute coronary syndromes. P LibbyCirculation200111457759No
2661878878.019.6219.6mTOR and cancer: insights into a complex relationship. David M SabatiniNat. Rev. Cancer200616915295No
2662878878.028.0228.0Persister cells, dormancy and infectious disease. Kim LewisNat. Rev. Microbiol.200717143318No
26631755877.557.7228.9Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. M A Pfeffer, E BraunwaldCirculation19902138525No
26641754877.00.00.0A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. R L Juliano, V LingBiochim. Biophys. Acta1976990323Yes
2665877877.00.00.0Experience from a multicentre stroke register: a preliminary report. S HatanoBull. World Health Organ.19761088404Yes
2666877877.00.00.0Relative and absolute strength of response as a function of frequency of reinforcement. R J HERRNSTEINJ Exp Anal Behav196113713775Yes
2667876876.032.9933.0Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. F HeftiJ. Neurosci.19863746405Yes
2668876876.022.3722.4The columnar organization of the neocortex. V B MountcastleBrain19979153131No
26691752876.042.4121.2The significance of digital gene expression profiles. S Audic, J M ClaverieGenome Res.19979331369Yes
2670876876.023.7223.7Natural history of chronic hepatitis C. Leonard B SeeffHepatology200212407575No
2671876876.031.931.9Water as an active constituent in cell biology. Philip BallChem. Rev.200818095715No
26721750875.00.00.0Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. E Engvall, P PerlmannImmunochemistry19715135623Yes
2673875875.016.316.3Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Eric C LaiNat. Genet.200211896390Yes
26741750875.067.433.7Stochastic relaxation, gibbs distributions, and the bayesian restoration of images. S Geman, D GemanIEEE Trans Pattern Anal Mach Intell198422499653Yes
26751749874.50.00.0Brain stem reticular formation and activation of the EEG. G Moruzzi, H W MagounElectroencephalogr Clin Neurophysiol194918421835Yes
2676874874.025.5525.6Tumor suppressor genes. R A WeinbergScience19911659741No
26775244874.0229.9438.3The occurrence of sleep-disordered breathing among middle-aged adults. T Young, M Palta, J Dempsey, J Skatrud, S Weber, S BadrN. Engl. J. Med.19938464434Yes
2678874874.029.8329.8Disseminating innovations in health care. Donald M BerwickJAMA200312697800Yes
2679874874.023.2123.2A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Lawrence SteinmanNat. Med.200717290272No
2680873873.032.9733.0Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. L A LiottaCancer Res.19862998604No
2681873873.00.00.0The interaction of a naphthalene dye with apomyoglobin and apohemoglobin. A fluorescent probe of non-polar binding sites. L StryerJ. Mol. Biol.19655867031Yes
2682873873.041.5441.5The structure of beta-lactamases. R P AmblerPhilos. Trans. R. Soc. Lond., B, Biol. Sci.19806109327Yes
2683873873.041.5241.5Carnitine--metabolism and functions. J BremerPhysiol. Rev.19836361812No
26842619873.0107.2535.8Qualitative research in health care. Analysing qualitative data. C Pope, S Ziebland, N MaysBMJ200010625273No
2685873873.022.4622.5Target-oriented and diversity-oriented organic synthesis in drug discovery. S L SchreiberScience200010720315No
2686873873.00.00.0LINKED FUNCTIONS AND RECIPROCAL EFFECTS IN HEMOGLOBIN: A SECOND LOOK. J WYMANAdv. Protein Chem.196414268785No
26871746873.046.023.0Blinded by the Light: The Growing Complexity of p53. Karen H Vousden, Carol PrivesCell200919410540No
2688873873.051.2851.3Whatever next? Predictive brains, situated agents, and the future of cognitive science. Andy ClarkBehav Brain Sci201323663408No
2689873873.080.0480.0The antibiotic resistance crisis: part 1: causes and threats. C Lee VentolaP T201525859123Yes
26902618872.778.5926.2Membrane lipids: where they are and how they behave. Gerrit van Meer, Dennis R Voelker, Gerald W FeigensonNat. Rev. Mol. Cell Biol.200818216768No
26911745872.564.9332.5Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. Aluísio J D Barros, Vânia N HirakataBMC Med Res Methodol200314567763Yes
2692872872.00.00.0Origin of concatemeric T7 DNA. J D WatsonNature New Biol.19724507727Yes
2693872872.026.9827.0Disorders of iron metabolism. N C AndrewsN. Engl. J. Med.199910607817No
26941744872.00.00.0A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines. A H ANTON, D F SAYREJ. Pharmacol. Exp. Ther.196214013351Yes
2695872872.021.7721.8Membrane recognition by phospholipid-binding domains. Mark A LemmonNat. Rev. Mol. Cell Biol.200818216767No
2696872872.036.9537.0The epidemiology of adult obstructive sleep apnea. Naresh M PunjabiProc Am Thorac Soc200818250205No
2697871871.040.6940.7A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes. S T TiffanyPsychol Rev19902186423No
2698871871.028.1428.1Linkage strategies for genetically complex traits. I. Multilocus models. N RischAm. J. Hum. Genet.19902301392Yes
2699871871.024.4124.4Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase. P KuzmicAnal. Biochem.19968660575Yes
27005226871.0135.2322.5Principal components analysis corrects for stratification in genome-wide association studies. Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David ReichNat. Genet.200616862161Yes
27014351870.2185.3337.1Posttraumatic stress disorder in the National Comorbidity Survey. R C Kessler, A Sonnega, E Bromet, M Hughes, C B NelsonArch. Gen. Psychiatry19957492257Yes
2702870870.037.8137.8Density matrix formulation for quantum renormalization groups. WhitePhys. Rev. Lett.199210046608Yes
2703870870.023.3123.3Plant salt tolerance. J K ZhuTrends Plant Sci.200111173290Yes
2704870870.00.00.0The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. S V BOYDENJ. Exp. Med.195114803635Yes
27052610870.077.4225.8Functional porous coordination polymers. Susumu Kitagawa, Ryo Kitaura, Shin-ichiro NoroAngew. Chem. Int. Ed. Engl.200415114565Yes
2706870870.019.4719.5ChIP-seq: advantages and challenges of a maturing technology. Peter J ParkNat. Rev. Genet.200919736561No
27074348869.6183.1836.6Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. J S Beckman, T W Beckman, J Chen, P A Marshall, B A FreemanProc. Natl. Acad. Sci. U.S.A.19902154753Yes
27081739869.540.4920.2Homeobox genes and axial patterning. W McGinnis, R KrumlaufCell19921346368No
2709869869.025.4525.4Chemistry and biology of the immunophilins and their immunosuppressive ligands. S L SchreiberScience19911702904No
2710869869.057.8257.8ROC methodology in radiologic imaging. C E MetzInvest Radiol19863095258No
2711869869.023.9323.9Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. J Denis McGarryDiabetes200211756317No
27121738869.055.9628.0Biology of incretins: GLP-1 and GIP. Laurie L Baggio, Daniel J DruckerGastroenterology200717498508No
27132605868.365.9922.0Generation of germline-competent induced pluripotent stem cells. Keisuke Okita, Tomoko Ichisaka, Shinya YamanakaNature200717554338Yes
2714868868.041.6641.7Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. R M PostAm J Psychiatry19921353322No
2715868868.00.00.0Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. J A MillerCancer Res.19704915745No
2716868868.056.8456.8Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. A M CarlssonPain19836602967Yes
2717868868.038.0238.0Checklists for improving rigour in qualitative research: a case of the tail wagging the dog? R S BarbourBMJ200111337448No
2718868868.027.127.1N-heterocyclic carbenes: a new concept in organometallic catalysis. Wolfgang A HerrmannAngew. Chem. Int. Ed. Engl.200219750753Yes
27192602867.376.1925.4Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. Y Zhang, M Brady, S SmithIEEE Trans Med Imaging200111293691Yes
2720867867.045.5745.6Bone "mass" and the "mechanostat": a proposal. H M FrostAnat. Rec.19873688455Yes
2721867867.00.00.0Structure and function of intercellular junctions. L A StaehelinInt. Rev. Cytol.19744611943No
2722867867.038.538.5The phenomenon of the acute phase response. I KushnerAnn. N. Y. Acad. Sci.19827046585No
27231734867.053.5226.8Molecular mechanisms of action of steroid/thyroid receptor superfamily members. M J Tsai, B W O'MalleyAnnu. Rev. Biochem.19947979245No
2724867867.031.1431.1The somatic marker hypothesis and the possible functions of the prefrontal cortex. A R DamasioPhilos. Trans. R. Soc. Lond., B, Biol. Sci.19968941953No
2725867867.019.8419.8Automated NMR structure calculation with CYANA. Peter GüntertMethods Mol. Biol.200415318003Yes
27261734867.066.1933.1An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. O Johnell, J A KanisOsteoporos Int200616983459Yes
27271732866.045.3522.7A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. C S Hoffman, F WinstonGene19873319781Yes
2728866866.021.3721.4GLIA: listening and talking to the synapse. P G HaydonNat. Rev. Neurosci.200111256079No
2729866866.022.0322.0Molecular imaging of cancer with positron emission tomography. Sanjiv Sam GambhirNat. Rev. Cancer200212209157No
2730866866.029.5429.5Infection in solid-organ transplant recipients. Jay A FishmanN. Engl. J. Med.200718094380No
27311731865.50.00.0Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. A Fabiato, F FabiatoJ. Physiol. (Paris)1979533865Yes
27321731865.563.0731.5Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. P Brugada, J BrugadaJ. Am. Coll. Cardiol.19921309182Yes
2733865865.036.1436.1Selective attention and the organization of visual information. J DuncanJ Exp Psychol Gen19846240521Yes
2734865865.017.9417.9The ubiquitin-proteasome pathway: on protein death and cell life. A CiechanoverEMBO J.19989857172No
27351730865.032.5816.3A synthetic oscillatory network of transcriptional regulators. M B Elowitz, S LeiblerNature200010659856Yes
2736865865.022.3522.4How neutrophils kill microbes. Anthony W SegalAnnu. Rev. Immunol.200515771570No
27371729864.563.2731.6Excitatory amino acids as a final common pathway for neurologic disorders. S A Lipton, P A RosenbergN. Engl. J. Med.19947905600No
27381727863.552.6926.3The protective effects of estrogen on the cardiovascular system. M E Mendelsohn, R H KarasN. Engl. J. Med.199910362825No
2739863863.026.4626.5The Trk family of neurotrophin receptors. M BarbacidJ. Neurobiol.19947852993No
2740863863.032.0932.1Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. M E BoutonPsychol Bull19938346330No
2741863863.023.5223.5Signal transduction via the MAP kinases: proceed at your own RSK. J BlenisProc. Natl. Acad. Sci. U.S.A.19938392180No
2742863863.040.9841.0UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. D W RussellJ Pers Assess19968576833Yes
2743863863.020.0520.1An overview of epithelio-mesenchymal transformation. E D HayActa Anat (Basel)19958714286No
2744863863.021.9521.9BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data. O GascuelMol. Biol. Evol.19979254330Yes
2745863863.018.9819.0Initiation of translation in prokaryotes and eukaryotes. M KozakGene199910395892No
2746863863.019.2219.2Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. A S BaldwinJ. Clin. Invest.200111160144No
2747863863.022.6222.6New ideas about atrial fibrillation 50 years on. Stanley NattelNature200211805846No
2748863863.00.00.0A NEW WEIGHTING SYSTEM FOR MEAN SURFACE TEMPERATURE OF THE HUMAN BODY. N L RAMANATHANJ Appl Physiol196414173555Yes
2749863863.00.00.0The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application. S HESTRINJ. Biol. Chem.194918133390Yes
2750862862.00.00.0The anterior approach for removal of ruptured cervical disks. R B CLOWARDJ. Neurosurg.195813599052Yes
27511724862.048.0424.0Modes of resistance to anti-angiogenic therapy. Gabriele Bergers, Douglas HanahanNat. Rev. Cancer200818650835No
27521724862.0170.3485.2Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. Ivica Letunic, Peer BorkNucleic Acids Res.201627095192Yes
27532585861.780.4626.8A nonparametric method for automatic correction of intensity nonuniformity in MRI data. J G Sled, A P Zijdenbos, A C EvansIEEE Trans Med Imaging19989617910Yes
27541723861.571.5635.8Role of oxidized low density lipoprotein in atherogenesis. J L Witztum, D SteinbergJ. Clin. Invest.19911752940No
2755861861.040.2240.2Spatial localization in NMR spectroscopy in vivo. P A BottomleyAnn. N. Y. Acad. Sci.19873326459No
27561722861.028.5914.3Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. T Lee, L LuoNeuron199910197526Yes
2757861861.032.9633.0Spatially heterogeneous dynamics in supercooled liquids. M D EdigerAnnu Rev Phys Chem200011031277Yes
2758861861.034.3734.4Platelet-rich plasma: evidence to support its use. Robert E MarxJ. Oral Maxillofac. Surg.200415085519No
2759861861.024.224.2Anatomy and regulation of the central melanocortin system. Roger D ConeNat. Neurosci.200515856065No
27601721860.575.9138.0Atomic structure and chemistry of human serum albumin. X M He, D C CarterNature19921630489Yes
27611721860.563.6431.8A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. A Ennaceur, J DelacourBehav. Brain Res.19883228475Yes
27621721860.50.00.0Immunoassay of insulin with insulin-antibody precipitate. C N HALES, P J RANDLEBiochem. J.196313952078Yes
27632581860.3121.4540.5Hepatocellular carcinoma. Alejandro Forner, Josep M Llovet, Jordi BruixLancet201222353262No
2764860860.00.00.0Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. M P BlausteinAm. J. Physiol.1977324293No
2765860860.028.028.0The mitochondrial electron transport and oxidative phosphorylation system. Y HatefiAnnu. Rev. Biochem.19852862839No
27661720860.092.7646.4Statistical methods in cancer research. Volume I - The analysis of case-control studies. N E Breslow, N E DayIARC Sci. Publ.19807216345Yes
2767860860.020.8520.9Up on the tightrope: natural killer cell activation and inhibition. Lewis L LanierNat. Immunol.200818425106No
27681719859.575.9638.0Physiological parameters in laboratory animals and humans. B Davies, T MorrisPharm. Res.19938378254No
2769859859.043.2643.3Assessing self-maintenance: activities of daily living, mobility, and instrumental activities of daily living. S KatzJ Am Geriatr Soc19836418786No
2770859859.023.1123.1A tension-based theory of morphogenesis and compact wiring in the central nervous system. D C Van EssenNature19979002514Yes
27714290858.0130.8226.2Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. T R Mosmann, H Cherwinski, M W Bond, M A Giedlin, R L CoffmanJ. Immunol.19862419430Yes
2772858858.025.0825.1A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. J MilbrandtScience19873672127Yes
2773858858.025.3925.4Looking into the functional architecture of the brain with diffusion MRI. Denis Le BihanNat. Rev. Neurosci.200312778119No
2774858858.025.2525.2Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis. Peter FranssonHum Brain Mapp200515852468Yes
2775858858.00.00.0Antigen-antibody reactions in gels. O OUCHTERLONYActa Pathol Microbiol Scand194918143039Yes
27765146857.7160.8526.8Prediction of coronary heart disease using risk factor categories. P W Wilson, R B D'Agostino, D Levy, A M Belanger, H Silbershatz, W B KannelCirculation19989603539Yes
27771714857.065.3432.7Quality control and preprocessing of metagenomic datasets. Robert Schmieder, Robert EdwardsBioinformatics201121278185Yes
27781714857.00.00.0Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. Zunyou Wu, Jennifer M McGooganJAMA202032091533Yes
27791713856.552.7526.4Protein oxidation in aging, disease, and oxidative stress. B S Berlett, E R StadtmanJ. Biol. Chem.19979252331No
2780856856.056.6256.6A "rationalized" arcsine transform. G A StudebakerJ Speech Hear Res19854046587Yes
2781856856.054.6154.6Derivation and validation of a short-form oral health impact profile. G D SladeCommunity Dent Oral Epidemiol19979332805Yes
27821712856.046.0923.0Emerging roles of caspase-3 in apoptosis. A G Porter, R U JänickeCell Death Differ.199910200555No
27835131855.2130.2421.7Obesity is associated with macrophage accumulation in adipose tissue. Stuart P Weisberg, Daniel McCann, Manisha Desai, Michael Rosenbaum, Rudolph L Leibel, Anthony W FerranteJ. Clin. Invest.200314679176Yes
2784855855.00.00.0Transformation of yeast by a replicating hybrid plasmid. J D BeggsNature1978357984Yes
2785855855.026.2526.2Supported membranes: scientific and practical applications. E SackmannScience19968539599No
27861710855.032.3616.2Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. W Gu, R G RoederCell19979288740Yes
2787855855.027.5427.5Inhibition of return. KleinTrends Cogn. Sci. (Regul. Ed.)200010740278Yes
27883420855.098.6824.7Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Michael D Greicius, Ben Krasnow, Allan L Reiss, Vinod MenonProc. Natl. Acad. Sci. U.S.A.200312506194Yes
27893420855.099.1424.8The epidemiology of sepsis in the United States from 1979 through 2000. Greg S Martin, David M Mannino, Stephanie Eaton, Marc MossN. Engl. J. Med.200312700374Yes
27901710855.038.0919.0Tumour-cell invasion and migration: diversity and escape mechanisms. Peter Friedl, Katarina WolfNat. Rev. Cancer200312724734No
27911710855.050.1525.1Principles of bioactive lipid signalling: lessons from sphingolipids. Yusuf A Hannun, Lina M ObeidNat. Rev. Mol. Cell Biol.200818216770No
27921710855.058.4529.2Integrins in cancer: biological implications and therapeutic opportunities. Jay S Desgrosellier, David A ChereshNat. Rev. Cancer201020029421No
2793855855.032.5132.5Persister cells. Kim LewisAnnu. Rev. Microbiol.201020528688No
2794855855.037.1937.2The amazing osteocyte. Lynda F BonewaldJ. Bone Miner. Res.201121254230No
27953417854.2117.5729.4Toxic potential of materials at the nanolevel. Andre Nel, Tian Xia, Lutz Mädler, Ning LiScience200616456071No
2796854854.060.6960.7Psychosocial resilience and protective mechanisms. Michael RutterAm J Orthopsychiatry19873303954No
2797854854.021.421.4The enzymes, regulation, and genetics of bile acid synthesis. David W RussellAnnu. Rev. Biochem.200312543708No
27982562854.00.00.0Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. D D SABATINI, K BENSCH, R J BARRNETTJ. Cell Biol.196313975866Yes
27991708854.00.00.0Chronic catheterization of the spinal subarachnoid space. T L Yaksh, T A RudyPhysiol. Behav.197614677603Yes
28001708854.055.5727.8ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control. Graham Noctor, Christine H. FoyerAnnu. Rev. Plant Physiol. Plant Mol. Biol.199815012235Yes
28013414853.5100.5625.1An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Joseph A Maldjian, Paul J Laurienti, Robert A Kraft, Jonathan H BurdetteNeuroimage200312880848Yes
28021707853.576.8938.4How useful is SBF in predicting in vivo bone bioactivity? Tadashi Kokubo, Hiroaki TakadamaBiomaterials200616448693No
28031706853.074.6837.3Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. A E Czeizel, I DudásN. Engl. J. Med.19921307234Yes
2804853853.00.00.0Displaced proximal humeral fractures. I. Classification and evaluation. C S NeerJ Bone Joint Surg Am19705455339Yes
28051706853.043.4521.7Long-term potentiation--a decade of progress? R C Malenka, R A NicollScience199910489359No
28061706853.043.6721.8Regeneration beyond the glial scar. Jerry Silver, Jared H MillerNat. Rev. Neurosci.200414735117No
2807853853.031.5931.6Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. Felix KratzJ Control Release200818582981No
2808852852.040.8240.8The P300 wave of the human event-related potential. T W PictonJ Clin Neurophysiol19921464675No
2809852852.025.7525.8Two-stage model of memory trace formation: a role for "noisy" brain states. G BuzsákiNeuroscience19892687720No
2810852852.022.7122.7ECM and cell surface proteolysis: regulating cellular ecology. Z WerbCell19979390552No
2811852852.035.4135.4Polybrominated diphenyl ethers in the environment and in people: a meta-analysis of concentrations. Ronald A HitesEnviron. Sci. Technol.200414998004Yes
2812852852.031.631.6G(ST) and its relatives do not measure differentiation. Lou JostMol. Ecol.200819238703Yes
2813852852.00.00.0An approximate distribution of estimates of variance components. F E SATTERTHWAITEBiometrics194620287815Yes
28141702851.00.00.0High resolution acrylamide gel electrophoresis of histones. S Panyim, R ChalkleyArch. Biochem. Biophys.19695778650Yes
2815851851.017.417.4Chronic myeloid leukemia. C L SawyersN. Engl. J. Med.199910219069No
2816851851.039.2339.2A review of psychological risk factors in back and neck pain. S J LintonSpine200010788861No
28171701850.5157.0178.5Facial nerve grading system. J W House, D E BrackmannOtolaryngol Head Neck Surg19853921901Yes
2818850850.047.5247.5How is the level of free arachidonic acid controlled in mammalian cells? R F IrvineBiochem. J.19826810878No
2819850850.020.8320.8mRNA stability in mammalian cells. J RossMicrobiol. Rev.19957565413No
28201700850.037.0818.5Proliferation, cell cycle and apoptosis in cancer. G I Evan, K H VousdenNature200111357141No
2821850850.00.00.0A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. D MATTINGLYJ. Clin. Pathol.196214471419Yes
2822850850.020.1920.2Gene finding in novel genomes. Ian KorfBMC Bioinformatics200415144565Yes
2823850850.019.019.0Telomeres and human disease: ageing, cancer and beyond. Maria A BlascoNat. Rev. Genet.200516136653No
2824850850.026.5526.6Mitochondrial fusion and fission in cell life and death. Benedikt WestermannNat. Rev. Mol. Cell Biol.201021102612No
28251699849.50.00.0Further improvements in the plaque technique for detecting single antibody-forming cells. A J Cunningham, A SzenbergImmunology19685653817Yes
2826849849.00.00.0Electrophoretic separation of plasma lipoproteins in agarose gel. R P NobleJ. Lipid Res.19684176473Yes
2827849849.028.6928.7Aging, energy, and oxidative stress in neurodegenerative diseases. M F BealAnn. Neurol.19957668820No
2828849849.028.4328.4Limbic-cortical dysregulation: a proposed model of depression. H S MaybergJ Neuropsychiatry Clin Neurosci19979276848No
28291697848.539.9720.0Dynamic instability of microtubule growth. T Mitchison, M KirschnerNature19846504138Yes
28302545848.387.2729.1Spirometric reference values from a sample of the general U.S. population. J L Hankinson, J R Odencrantz, K B FedanAm. J. Respir. Crit. Care Med.19999872837Yes
2831848848.00.00.0Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. U UngerstedtActa Physiol Scand Suppl19714332693Yes
2832848848.028.6628.7Presynaptic nicotinic ACh receptors. S WonnacottTrends Neurosci.19979023878No
28331696848.037.7118.9Cellular functions regulated by Src family kinases. S M Thomas, J S BruggeAnnu. Rev. Cell Dev. Biol.19979442882No
2834848848.023.023.0G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. Jeffery T DavisAngew. Chem. Int. Ed. Engl.200414755695No
2835848848.016.6916.7The anaphase promoting complex/cyclosome: a machine designed to destroy. Jan-Michael PetersNat. Rev. Mol. Cell Biol.200616896351No
2836848848.023.9523.9Principles and challenges of genomewide DNA methylation analysis. Peter W LairdNat. Rev. Genet.201020125086No
28374238847.693.9218.8Electrostatics of nanosystems: application to microtubules and the ribosome. N A Baker, D Sept, S Joseph, M J Holst, J A McCammonProc. Natl. Acad. Sci. U.S.A.200111517324Yes
2838847847.028.8728.9Pharmacology of cannabinoid CB1 and CB2 receptors. R G PertweePharmacol. Ther.19979336020No
2839847847.018.3418.3Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins. M D ReshBiochim. Biophys. Acta199910446384No
2840846846.00.00.0An approach for the treatment of penile carcinoma. R M CabanasCancer1977837331Yes
28411692846.038.0319.0Community structure in social and biological networks. M Girvan, M E J NewmanProc. Natl. Acad. Sci. U.S.A.200212060727No
2842846846.00.00.0A cytoarchitectonic atlas of the spinal cord in the cat. B REXEDJ. Comp. Neurol.195413163236Yes
28432538846.079.9626.7Bacterial biofilms: from the natural environment to infectious diseases. Luanne Hall-Stoodley, J William Costerton, Paul StoodleyNat. Rev. Microbiol.200415040259No
28441692846.045.9623.0Cellular processing of platinum anticancer drugs. Dong Wang, Stephen J LippardNat Rev Drug Discov200515789122No
2845846846.025.7325.7Wound healing and its impairment in the diabetic foot. Vincent FalangaLancet200516291068No
2846846846.021.7121.7The integration of macromolecular diffraction data. Andrew G W LeslieActa Crystallogr. D Biol. Crystallogr.200616369093No
28471692846.060.0530.0Titanium dioxide nanomaterials: synthesis, properties, modifications, and applications. Xiaobo Chen, Samuel S MaoChem. Rev.200717590053Yes
28481691845.544.1322.1Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. G A Gonzalez, M R MontminyCell19892573431Yes
28491691845.536.8718.4Rho GTPases and signaling networks. L Van Aelst, C D'Souza-SchoreyGenes Dev.19979308960No
28501690845.047.3723.7Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. M E Feder, G E HofmannAnnu. Rev. Physiol.199910099689No
2851845845.030.4530.4Cytokinesis-block micronucleus cytome assay. Michael FenechNat Protoc200717546000Yes
28523379844.8100.8425.2Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. J E Walker, M Saraste, M J Runswick, N J GayEMBO J.19826329717Yes
28536758844.8219.8727.5A method and server for predicting damaging missense mutations. Ivan A Adzhubei, Steffen Schmidt, Leonid Peshkin, Vasily E Ramensky, Anna Gerasimova, Peer Bork, Alexey S Kondrashov, Shamil R SunyaevNat. Methods201020354512Yes
28541689844.50.00.0A method of trace iodination of proteins for immunologic studies. P J McConahey, F J DixonInt. Arch. Allergy Appl. Immunol.19664160044Yes
2855844844.025.4625.5Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. G BodenDiabetes19978971073No
2856844844.022.5622.6Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. H J DargieLancet200111356434Yes
28571688844.032.6716.3An extensive class of small RNAs in Caenorhabditis elegans. R C Lee, V AmbrosScience200111679672Yes
2858844844.00.00.0The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. G A ROSEBull. World Health Organ.196213974778Yes
2859844844.016.9917.0TNF/TNFR family members in costimulation of T cell responses. Tania H WattsAnnu. Rev. Immunol.200515771565No
2860843843.032.6632.7Signaling through phosphatidylcholine breakdown. J H ExtonJ. Biol. Chem.19902104616No
2861843843.031.6831.7Fibronectin and its receptors. E RuoslahtiAnnu. Rev. Biochem.19882972252No
2862843843.022.6522.6The prefrontal cortex--an update: time is of the essence. J M FusterNeuron200111394996No
2863842842.00.00.0Fundamental patterns of knowing in nursing. B CarperANS Adv Nurs Sci1978110216Yes
28642526842.081.9527.3Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). R S Spielman, R E McGinnis, W J EwensAm. J. Hum. Genet.19938447318Yes
28652526842.060.2420.1TGF-beta signalling from cell membrane to nucleus through SMAD proteins. C H Heldin, K Miyazono, P ten DijkeNature19979393997No
28661684842.00.00.0The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid. B N AMES, D T DUBINJ. Biol. Chem.196013793161Yes
2867841841.042.8942.9A spreading-activation theory of retrieval in sentence production. G S DellPsychol Rev19863749399Yes
2868841841.00.00.0The prevalence of 'alexithymic' characteristics in psychosomatic patients. P E SifneosPsychother Psychosom19734770536Yes
2869841841.056.0156.0The clinical application of the biopsychosocial model. G L EngelAm J Psychiatry19807369396Yes
2870841841.033.0233.0Low-molecular-weight heparins. J I WeitzN. Engl. J. Med.19979278467No
28711682841.032.4916.2Effective targeted gene 'knockdown' in zebrafish. A Nasevicius, S C EkkerNat. Genet.200011017081Yes
2872841841.023.7223.7Context and behavioral processes in extinction. Mark E BoutonLearn. Mem.200415466298No
28732521840.378.5526.2Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. M K Parmar, V Torri, L StewartStat Med19989921604Yes
28743361840.2106.0826.5Real time quantitative PCR. C A Heid, J Stevens, K J Livak, P M WilliamsGenome Res.19968908518Yes
28751680840.063.0331.5A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR. V L Miller, J J MekalanosJ. Bacteriol.19882836362Yes
2876840840.021.6421.6At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. M KozakJ. Mol. Biol.19873681984Yes
2877840840.028.1528.1The effects of stressful life events on depression. R C KesslerAnnu Rev Psychol19979046559No
2878840840.026.7826.8The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. R A JainBiomaterials200011055295No
2879840840.029.6229.6Insecticide-treated bed nets and curtains for preventing malaria. C LengelerCochrane Database Syst Rev200415106149No
2880840840.029.7629.8Cholinesterase inhibitors for Alzheimer's disease. J BirksCochrane Database Syst Rev200616437532No
2881840840.019.1419.1The evolutionary significance of cis-regulatory mutations. Gregory A WrayNat. Rev. Genet.200717304246No
2882839839.041.8741.9Infection by verocytotoxin-producing Escherichia coli. M A KarmaliClin. Microbiol. Rev.19892644022No
2883839839.023.3823.4Amyloid, the presenilins and Alzheimer's disease. J HardyTrends Neurosci.19979106355No
2884839839.021.1721.2Dendritic cells: unique leukocyte populations which control the primary immune response. D N HartBlood19979345009No
2885839839.023.4823.5Differential projections of the infralimbic and prelimbic cortex in the rat. Robert P VertesSynapse200414579424Yes
28861678839.059.3929.7Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Taro Kawai, Shizuo AkiraImmunity201121616434No
28871677838.558.7129.4The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. W L Jorgensen, J Tirado-RivesJ. Am. Chem. Soc.198827557051Yes
2888838838.028.6228.6The fetal and infant origins of adult disease. D J BarkerBMJ19902252919No
28891676838.061.8830.9Compilation and analysis of Escherichia coli promoter DNA sequences. D K Hawley, W R McClureNucleic Acids Res.19836344016No
2890838838.027.1127.1Molecular drive: a cohesive mode of species evolution. G DoverNature19827110332Yes
2891838838.021.7121.7The state of lipid rafts: from model membranes to cells. Michael EdidinAnnu Rev Biophys Biomol Struct200312543707No
28921676838.084.7442.4Van der Waals heterostructures. A K Geim, I V GrigorievaNature201323887427Yes
28937540837.8318.8435.4STAR: ultrafast universal RNA-seq aligner. Alexander Dobin, Carrie A Davis, Felix Schlesinger, Jorg Drenkow, Chris Zaleski, Sonali Jha, Philippe Batut, Mark Chaisson, Thomas R GingerasBioinformatics201323104886Yes
28942513837.780.526.8Methods in mammalian autophagy research. Noboru Mizushima, Tamotsu Yoshimori, Beth LevineCell201020144757Yes
28951675837.50.00.0Solubilization of membranes by detergents. A Helenius, K SimonsBiochim. Biophys. Acta19751091302No
28961675837.542.9821.5Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Nahum Sonenberg, Alan G HinnebuschCell200919239892No
2897837837.021.6321.6Molecular mechanisms of myocardial remodeling. B SwynghedauwPhysiol. Rev.19999922372No
2898837837.015.1215.1SCF and Cullin/Ring H2-based ubiquitin ligases. R J DeshaiesAnnu. Rev. Cell Dev. Biol.199910611969No
2899837837.021.4321.4Epstein-Barr virus infection. J I CohenN. Engl. J. Med.200010944566No
2900836836.028.8528.9Comparing evolvability and variability of quantitative traits. D HouleGenetics19921732160Yes
2901836836.0113.99114.0The analysis of errors in orthodontic measurements. W J HoustonAm J Orthod19836573846Yes
2902836836.048.0648.1Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. E H BeacheyJ. Infect. Dis.19817014727No
2903836836.048.7148.7Toward terminological, conceptual, and statistical clarity in the study of mediators and moderators: examples from the child-clinical and pediatric psychology literatures. G N HolmbeckJ Consult Clin Psychol19979256561Yes
2904836836.028.4428.4Venous thrombosis: a multicausal disease. F R RosendaalLancet199910209995No
2905836836.031.3831.4MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Amy E PasquinelliNat. Rev. Genet.201222411466No
29061671835.540.1220.1InterProScan--an integration platform for the signature-recognition methods in InterPro. E M Zdobnov, R ApweilerBioinformatics200111590104Yes
29079187835.2379.8434.5A new equation to estimate glomerular filtration rate. Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Lucy Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul Eggers, Frederick Van Lente, Tom Greene, Josef CoreshAnn. Intern. Med.200919414839Yes
29081670835.00.00.0Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice. J D McGhee, P H von HippelJ. Mol. Biol.19744416620Yes
2909835835.036.2936.3Socioeconomic disadvantage and child development. V C McLoydAm Psychol19989491747No
2910834834.00.00.0Stimulus-secretion coupling: the concept and clues from chromaffin and other cells. W W DouglasBr. J. Pharmacol.19684882190No
2911834834.00.00.06-Hydroxy-dopamine induced degeneration of central monoamine neurons. U UngerstedtEur. J. Pharmacol.19685718510Yes
2912834834.022.7422.7Seed Germination and Dormancy. J. D. BewleyPlant Cell199712237375Yes
29135002833.7154.1925.7Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. S Yusuf, P Sleight, J Pogue, J Bosch, R Davies, G DagenaisN. Engl. J. Med.200010639539Yes
29145001833.5182.3330.4Free radicals and antioxidants in normal physiological functions and human disease. Marian Valko, Dieter Leibfritz, Jan Moncol, Mark T D Cronin, Milan Mazur, Joshua TelserInt. J. Biochem. Cell Biol.200716978905No
2915833833.021.5221.5Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. R H SchwartzCell19921335362No
2916833833.022.8522.9Atherosclerosis is an inflammatory disease. R RossAm. Heart J.199910539839No
29171666833.035.8917.9AP-1 as a regulator of cell life and death. Eitan Shaulian, Michael KarinNat. Cell Biol.200211988758No
2918833833.021.5121.5r8s: inferring absolute rates of molecular evolution and divergence times in the absence of a molecular clock. Michael J SandersonBioinformatics200312538260Yes
2919833833.00.00.0A modified procedure for lead staining of thin sections. G MILLONIGJ Biophys Biochem Cytol196114474176Yes
2920833833.017.017.0Dendritic-cell control of pathogen-driven T-cell polarization. Martien L KapsenbergNat. Rev. Immunol.200314647480No
29211666833.052.0326.0Recent developments in the MAFFT multiple sequence alignment program. Kazutaka Katoh, Hiroyuki TohBrief. Bioinformatics200818372315Yes
29221665832.550.9225.5ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. Markus Wiederstein, Manfred J SipplNucleic Acids Res.200717517781Yes
29234993832.2152.4925.4The capsaicin receptor: a heat-activated ion channel in the pain pathway. M J Caterina, M A Schumacher, M Tominaga, T A Rosen, J D Levine, D JuliusNature19979349813Yes
2924832832.033.8733.9Computer programs for calculating total from specified free or free from specified total ionic concentrations in aqueous solutions containing multiple metals and ligands. A FabiatoMeth. Enzymol.19883231093Yes
29251664832.039.0919.5IAP family proteins--suppressors of apoptosis. Q L Deveraux, J C ReedGenes Dev.19999990849No
2926832832.017.0817.1MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. Victor AmbrosCell200312809598No
2927832832.016.9316.9NFAT proteins: key regulators of T-cell development and function. Fernando MacianNat. Rev. Immunol.200515928679No
2928832832.024.0124.0Tumour necrosis factor and cancer. Frances BalkwillNat. Rev. Cancer200919343034No
29291663831.580.5740.3Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. A I Basbaum, H L FieldsAnnu. Rev. Neurosci.19846143527No
29302494831.3118.0939.4Neighborhoods and violent crime: a multilevel study of collective efficacy. R J Sampson, S W Raudenbush, F EarlsScience19979252316Yes
29312494831.3104.5634.9Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. B K Matuszewski, M L Constanzer, C M Chavez-EngAnal. Chem.200312964746Yes
2932831831.034.9234.9Protein damage and degradation by oxygen radicals. I. general aspects. K J DaviesJ. Biol. Chem.19873036875Yes
29331662831.00.00.0The hitch-hiking effect of a favourable gene. J M Smith, J HaighGenet. Res.19744407212Yes
2934831831.020.5720.6Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. H E RuleyNature19836308473Yes
29352493831.085.1828.4A sensitive and reliable locomotor rating scale for open field testing in rats. D M Basso, M S Beattie, J C BresnahanJ. Neurotrauma19957783230Yes
2936831831.024.3724.4PHOTOPROTECTION REVISITED: Genetic and Molecular Approaches. Krishna K. NiyogiAnnu. Rev. Plant Physiol. Plant Mol. Biol.199915012213Yes
29374154830.886.4217.3The protein kinase complement of the human genome. G Manning, D B Whyte, R Martinez, T Hunter, S SudarsanamScience200212471243No
29383322830.595.023.8Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. L M Guzman, D Belin, M J Carson, J BeckwithJ. Bacteriol.19957608087Yes
2939830830.019.7819.8Cytokine receptor signalling. J N IhleNature19957566171No
29401660830.043.4821.7Obesity and insulin resistance. B B Kahn, J S FlierJ. Clin. Invest.200010953022No
2941830830.015.715.7Roles of the NKG2D immunoreceptor and its ligands. David H RauletNat. Rev. Immunol.200314523385No
2942830830.028.2328.2A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Ron HardmanEnviron. Health Perspect.200616451849No
2943830830.050.4650.5Statistics corner: A guide to appropriate use of correlation coefficient in medical research. M M MukakaMalawi Med J201223638278Yes
2944829829.00.00.0Renin-angiotensin system: biochemistry and mechanisms of action. M J PeachPhysiol. Rev.1977191856No
2945829829.019.2619.3Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. D HanahanNature19852986015Yes
29461658829.037.6218.8A survey of telomerase activity in human cancer. J W Shay, S BacchettiEur. J. Cancer19979282118No
2947829829.018.9719.0The Sp-family of transcription factors. G SuskeGene199910570957No
2948829829.018.7118.7VEGF and the quest for tumour angiogenesis factors. Napoleone FerraraNat. Rev. Cancer200212360282No
29492485828.363.6921.2Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Axel Nimmerjahn, Frank Kirchhoff, Fritjof HelmchenScience200515831717Yes
2950828828.031.3431.3Cytochrome oxidase: an endogenous metabolic marker for neuronal activity. M T Wong-RileyTrends Neurosci.19892469224No
2951828828.024.8824.9Cells in stress: transcriptional activation of heat shock genes. R I MorimotoScience19938451637No
2952828828.024.2224.2Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Richard C ScarpullaPhysiol. Rev.200818391175No
2953828828.049.7549.8The emerging role of lncRNAs in cancer. Maite HuarteNat. Med.201526540387No
29541655827.542.921.4Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set. N Sreerama, R W WoodyAnal. Biochem.200011112271Yes
2955827827.038.6538.6Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. J N WasserheitSex Transm Dis19921595015No
29561654827.041.7220.9Multiple nuclear factors interact with the immunoglobulin enhancer sequences. R Sen, D BaltimoreCell19863091258Yes
29571654827.00.00.0Calcium-dependent bacteriophage DNA infection. M Mandel, A HigaJ. Mol. Biol.19704922220Yes
2958827827.027.2627.3Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Michael F HolickAm. J. Clin. Nutr.200414985208No
29592481827.059.0919.7Adjusting batch effects in microarray expression data using empirical Bayes methods. W Evan Johnson, Cheng Li, Ariel RabinovicBiostatistics200716632515Yes
29601653826.541.1520.6Roles of CHOP/GADD153 in endoplasmic reticulum stress. S Oyadomari, M MoriCell Death Differ.200414685163No
29613305826.287.1721.8Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. E Schreiber, P Matthias, M M Müller, W SchaffnerNucleic Acids Res.19892771659Yes
29621652826.00.00.0Peptidoglycan types of bacterial cell walls and their taxonomic implications. K H Schleifer, O KandlerBacteriol Rev19724568761No
29631652826.075.8937.9Excitatory amino acid transmitters. J C Watkins, R H EvansAnnu. Rev. Pharmacol. Toxicol.19816112965No
2964826826.024.2824.3Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: a proposal for a synonymous codon choice that is optimal for the E. coli translational system. T IkemuraJ. Mol. Biol.19816175758Yes
2965826826.00.00.0Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. G D WINTERNature196214007593Yes
2966826826.036.2136.2AmpC beta-lactamases. George A JacobyClin. Microbiol. Rev.200919136439No
29671651825.541.620.8microRNA functions. Natascha Bushati, Stephen M CohenAnnu. Rev. Cell Dev. Biol.200717506695No
29681650825.00.00.0Epidermal growth factor. G Carpenter, S CohenAnnu. Rev. Biochem.1979382984No
2969825825.026.7226.7The sphingomyelin cycle and the second messenger function of ceramide. Y A HannunJ. Biol. Chem.19948106344No
2970825825.028.0428.0Synchronization of cortical activity and its putative role in information processing and learning. W SingerAnnu. Rev. Physiol.19938466179No
2971825825.024.6824.7Neuropathology of Parkinson's disease. L S FornoJ. Neuropathol. Exp. Neurol.19968786384No
2972825825.030.6430.6Stronger Brønsted acids. Takahiko AkiyamaChem. Rev.200717983247Yes
2973825825.00.00.0A simple objective technique for measuring flexibility in thinking. E A BERGJ Gen Psychol194818889466Yes
29741649824.545.4322.7RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. M B Shapiro, P SenapathyNucleic Acids Res.19873658675Yes
29752473824.394.8231.6SeaView version 4: A multiplatform graphical user interface for sequence alignment and phylogenetic tree building. Manolo Gouy, Stéphane Guindon, Olivier GascuelMol. Biol. Evol.201019854763Yes
2976824824.00.00.0Letter: Grading of angina pectoris. L CampeauCirculation1976947585Yes
2977824824.067.5967.6A method of analysing interview transcripts in qualitative research. P BurnardNurse Educ Today19911775125Yes
29782472824.0112.3237.4Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. P S Walsh, D A Metzger, R HiguchiBioTechniques19911867860Yes
2979824824.034.9935.0Post-hoc probing of significant moderational and mediational effects in studies of pediatric populations. Grayson N HolmbeckJ Pediatr Psychol2002